Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000899-TA|BGIBMGA000899-PA|IPR009053|Prefoldin
(724 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein. 101 7e-21
AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein. 101 9e-21
AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein. 101 9e-21
BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 100 2e-20
BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 100 2e-20
AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein. 100 2e-20
X64838-1|CAA46050.1| 1427|Homo sapiens restin protein. 99 3e-20
BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein. 99 3e-20
M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protei... 100 4e-20
BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein. 99 6e-20
BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containi... 98 1e-19
AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a varian... 97 2e-19
M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein. 96 3e-19
AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein. 96 3e-19
AB053469-1|BAC54108.1| 720|Homo sapiens ELKS gamma protein. 95 6e-19
AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein. 91 1e-17
AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein. 91 1e-17
D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heav... 91 1e-17
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 91 2e-17
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 91 2e-17
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 91 2e-17
AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring prot... 91 2e-17
AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein. 91 2e-17
AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein. 91 2e-17
U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein. 89 4e-17
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 89 4e-17
Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein. 89 7e-17
AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein p... 89 7e-17
AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein. 89 7e-17
AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-... 88 1e-16
X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein. 87 2e-16
X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein. 87 2e-16
U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein. 87 2e-16
D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 prot... 87 3e-16
DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein. 87 3e-16
AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein. 87 3e-16
Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated microtub... 84 1e-15
J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplak... 84 2e-15
AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb ... 84 2e-15
X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein. 83 3e-15
AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransfera... 83 3e-15
L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated prote... 83 3e-15
BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2, ... 83 3e-15
AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa ... 83 3e-15
AL139421-4|CAI22511.1| 720|Homo sapiens coiled-coil domain cont... 82 8e-15
BX538186-1|CAD98058.1| 971|Homo sapiens hypothetical protein pr... 81 1e-14
AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein. 81 1e-14
U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein. 81 2e-14
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 80 2e-14
BX538286-1|CAD98081.1| 724|Homo sapiens hypothetical protein pr... 80 2e-14
AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golg... 80 2e-14
AB208965-1|BAD92202.1| 705|Homo sapiens Rho-associated, coiled-... 80 2e-14
X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for ... 80 3e-14
X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 ... 80 3e-14
BX537964-1|CAD97928.1| 898|Homo sapiens hypothetical protein pr... 80 3e-14
BC105632-1|AAI05633.1| 898|Homo sapiens chromosome 10 open read... 80 3e-14
BC100670-1|AAI00671.1| 1004|Homo sapiens C10orf118 protein protein. 80 3e-14
BC060769-1|AAH60769.2| 1107|Homo sapiens chromosome 6 open readi... 80 3e-14
AL365275-1|CAI40383.1| 1140|Homo sapiens chromosome 6 open readi... 80 3e-14
AL137009-1|CAI20344.1| 1140|Homo sapiens chromosome 6 open readi... 80 3e-14
AL132874-2|CAI42604.1| 1140|Homo sapiens chromosome 6 open readi... 80 3e-14
AK091682-1|BAC03719.1| 936|Homo sapiens protein ( Homo sapiens ... 80 3e-14
BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-... 79 4e-14
AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens ... 79 4e-14
U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein. 79 5e-14
U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protei... 79 5e-14
BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein. 79 5e-14
AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F, 3... 79 5e-14
AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F, 3... 79 5e-14
AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein... 79 5e-14
AB035898-1|BAB03309.1| 1388|Homo sapiens kinesin-like protein 2 ... 79 5e-14
BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein. 79 7e-14
AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain cont... 79 7e-14
AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain cont... 79 7e-14
X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy ch... 78 1e-13
X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mR... 78 1e-13
D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heav... 78 1e-13
BC086869-1|AAH86869.1| 954|Homo sapiens FLJ25770 protein protein. 78 1e-13
AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical rhabdomyos... 78 1e-13
BC103499-1|AAI03500.1| 898|Homo sapiens chromosome 10 open read... 78 1e-13
AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/... 78 1e-13
AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein. 78 1e-13
X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy... 77 2e-13
X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal ... 77 2e-13
M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain p... 77 2e-13
M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain p... 77 2e-13
EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7, ... 77 2e-13
BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex pr... 77 2e-13
BC117174-1|AAI17175.1| 1291|Homo sapiens KIF15 protein protein. 77 2e-13
BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7, ... 77 2e-13
BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7, ... 77 2e-13
AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antige... 77 2e-13
AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex pr... 77 2e-13
AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex pr... 77 2e-13
AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex pr... 77 2e-13
AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110... 77 2e-13
AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110... 77 2e-13
AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110... 77 2e-13
AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein. 77 2e-13
AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain... 77 2e-13
AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein. 77 2e-13
AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-... 77 2e-13
AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated pr... 77 2e-13
AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypepti... 77 2e-13
Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heav... 77 2e-13
X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin he... 77 2e-13
BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6, ... 77 2e-13
BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,... 77 2e-13
BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,... 77 2e-13
AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin he... 77 2e-13
AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin he... 77 2e-13
AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY... 77 2e-13
AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein. 77 2e-13
BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1, ... 77 3e-13
AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting cit... 76 4e-13
AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens ... 76 4e-13
AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein. 76 4e-13
Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9, no... 76 5e-13
CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein. 76 5e-13
BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein pr... 76 5e-13
AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy... 76 5e-13
M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle... 75 7e-13
BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein. 75 9e-13
BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with ... 75 9e-13
BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with ... 75 9e-13
BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein. 75 9e-13
BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein. 75 9e-13
AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein. 75 9e-13
AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein. 75 9e-13
AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein. 75 9e-13
BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,... 75 1e-12
BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for IM... 75 1e-12
AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20... 75 1e-12
M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy cha... 74 2e-12
M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein. 74 2e-12
BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,... 74 2e-12
AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein p... 74 2e-12
Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein. 74 2e-12
AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein. 74 2e-12
X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (... 73 3e-12
BC113524-1|AAI13525.1| 578|Homo sapiens IFT74 protein protein. 73 3e-12
AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein. 73 3e-12
AY131226-1|AAN07912.1| 681|Homo sapiens medulloblastoma antigen... 73 3e-12
AY040325-1|AAK77221.1| 600|Homo sapiens capillary morphogenesis... 73 3e-12
AL356133-4|CAH72643.1| 600|Homo sapiens intraflagellar transpor... 73 3e-12
AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment e... 73 3e-12
L01042-1|AAD54608.1| 1093|Homo sapiens TATA element modulatory f... 73 4e-12
D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein. 73 4e-12
BC126123-1|AAI26124.1| 1093|Homo sapiens TATA element modulatory... 73 4e-12
BC117418-1|AAI17419.1| 1093|Homo sapiens TATA element modulatory... 73 4e-12
AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein. 73 4e-12
AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein. 73 4e-12
AB209109-1|BAD92346.1| 1096|Homo sapiens TATA element modulatory... 73 4e-12
BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 1... 73 5e-12
AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain prot... 73 5e-12
AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein. 73 5e-12
Z54367-1|CAA91196.1| 4684|Homo sapiens plectin protein. 72 6e-12
U93121-1|AAB88727.1| 753|Homo sapiens M-phase phosphoprotein-1 ... 72 6e-12
AY739715-1|AAW65984.1| 617|Homo sapiens M-phase phosphoprotein ... 72 6e-12
AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein ... 72 6e-12
AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related... 72 6e-12
BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/C... 72 8e-12
BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein. 72 8e-12
AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250... 72 8e-12
AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associ... 72 8e-12
AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein. 72 8e-12
BX537985-1|CAD97945.1| 1202|Homo sapiens hypothetical protein pr... 71 1e-11
L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein. 71 1e-11
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 71 1e-11
D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein. 71 1e-11
BX537759-1|CAD97828.1| 1763|Homo sapiens hypothetical protein pr... 71 1e-11
BX537708-1|CAD97819.1| 1605|Homo sapiens hypothetical protein pr... 71 1e-11
BX537421-1|CAD97663.1| 1204|Homo sapiens hypothetical protein pr... 71 1e-11
BC050555-1|AAH50555.1| 873|Homo sapiens KTN1 protein protein. 71 1e-11
AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 prot... 71 1e-11
AL590642-2|CAH70770.1| 862|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL590642-1|CAH70769.1| 1893|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL391870-2|CAI40925.1| 1893|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL391870-1|CAI40926.1| 862|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL353736-2|CAI40654.1| 862|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL353736-1|CAI40653.1| 1893|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL138836-2|CAI16963.1| 1893|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AL138836-1|CAI16964.1| 862|Homo sapiens CDK5 regulatory subunit... 71 1e-11
AF448860-1|AAP41926.1| 1893|Homo sapiens hypothetical protein pr... 71 1e-11
AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein. 71 1e-11
AB046853-1|BAB13459.2| 1852|Homo sapiens KIAA1633 protein protein. 71 1e-11
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 71 1e-11
BC117132-1|AAI17133.1| 1306|Homo sapiens kinectin 1 (kinesin rec... 71 2e-11
BC112337-1|AAI12338.1| 1306|Homo sapiens kinectin 1 (kinesin rec... 71 2e-11
AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protei... 71 2e-11
AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein ... 71 2e-11
AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein ... 71 2e-11
AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein ... 71 2e-11
AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein ... 71 2e-11
AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protei... 71 2e-11
AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protei... 71 2e-11
AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protei... 71 2e-11
AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protei... 71 2e-11
AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin he... 71 2e-11
AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin he... 71 2e-11
M63618-1|AAA35606.1| 2095|Homo sapiens bullous pemphigoid antige... 70 3e-11
M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain beta-s... 70 3e-11
L11690-1|AAA52288.1| 2649|Homo sapiens bullous pemphigoid antige... 70 3e-11
BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting p... 70 3e-11
BC023021-1|AAH23021.1| 731|Homo sapiens golgi autoantigen, golg... 70 3e-11
AY644768-1|AAV85456.1| 731|Homo sapiens cell proliferation-indu... 70 3e-11
AL096710-6|CAI22047.1| 2649|Homo sapiens dystonin protein. 70 3e-11
AF085199-1|AAD09753.1| 731|Homo sapiens golgin-84 protein. 70 3e-11
AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome assoc... 70 3e-11
Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein. 70 3e-11
X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa pro... 70 3e-11
BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein. 70 3e-11
AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A p... 70 3e-11
AL832009-1|CAD89912.1| 1177|Homo sapiens hypothetical protein pr... 70 3e-11
AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein. 70 3e-11
M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy ch... 69 6e-11
AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antige... 69 6e-11
AK025632-1|BAB15196.1| 720|Homo sapiens protein ( Homo sapiens ... 69 6e-11
AF212162-1|AAF23015.2| 2096|Homo sapiens ninein protein. 69 6e-11
X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein. 69 8e-11
AY736182-1|AAU86898.1| 1989|Homo sapiens ninein isoform 6 protein. 69 8e-11
AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter r... 69 8e-11
AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter r... 69 8e-11
AF302773-1|AAG33512.2| 2090|Homo sapiens ninein-Lm isoform protein. 69 8e-11
AF223939-1|AAK00630.1| 2073|Homo sapiens ninein isotype 3 protein. 69 8e-11
AF223938-1|AAK00629.1| 2069|Homo sapiens ninein isotype 2 protein. 69 8e-11
AF223937-1|AAK00628.1| 2029|Homo sapiens ninein isotype 1 protein. 69 8e-11
AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein. 68 1e-10
AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein. 68 1e-10
AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein. 68 1e-10
AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein. 68 1e-10
AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein. 68 1e-10
AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein. 68 1e-10
AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein. 68 1e-10
AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein. 68 1e-10
X63105-1|CAA44819.1| 726|Homo sapiens Tpr protein. 68 1e-10
X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (... 68 1e-10
U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein. 68 1e-10
U63610-1|AAB05428.1| 4574|Homo sapiens plectin protein. 68 1e-10
U53204-1|AAB05427.1| 4574|Homo sapiens plectin protein. 68 1e-10
M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac m... 68 1e-10
BC094764-1|AAH94764.1| 692|Homo sapiens TPR protein protein. 68 1e-10
BC057235-1|AAH57235.1| 613|Homo sapiens HMMR protein protein. 68 1e-10
BC028423-1|AAH28423.1| 1022|Homo sapiens PMFBP1 protein protein. 68 1e-10
BC016514-1|AAH16514.1| 687|Homo sapiens TPR protein protein. 68 1e-10
AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein pr... 68 1e-10
AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens ... 68 1e-10
AL137265-1|CAB70664.1| 992|Homo sapiens hypothetical protein pr... 67 2e-10
AF273054-1|AAM44457.1| 613|Homo sapiens CTCL tumor antigen HD-C... 67 2e-10
AB028975-1|BAA83004.2| 1456|Homo sapiens KIAA1052 protein protein. 67 2e-10
BC090932-1|AAH90932.1| 1377|Homo sapiens NIN protein protein. 67 2e-10
AF032862-1|AAC32548.1| 724|Homo sapiens intracellular hyaluroni... 67 2e-10
AB046785-1|BAB13391.2| 1313|Homo sapiens KIAA1565 protein protein. 67 2e-10
X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain ... 66 3e-10
BC048203-1|AAH48203.1| 663|Homo sapiens Unknown (protein for IM... 66 3e-10
AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein. 66 3e-10
AF485338-1|AAL93149.1| 1498|Homo sapiens golgin-160 protein. 66 3e-10
U29343-1|AAC52049.1| 725|Homo sapiens hyaluronan receptor protein. 66 4e-10
BX530088-4|CAI95787.1| 625|Homo sapiens GRIP1 associated protei... 66 4e-10
BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-... 66 4e-10
BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-... 66 4e-10
BC126912-1|AAI26913.1| 1132|Homo sapiens CROCC protein protein. 66 4e-10
BC126911-1|AAI26912.1| 1132|Homo sapiens CROCC protein protein. 66 4e-10
BC068006-1|AAH68006.1| 627|Homo sapiens ERC1 protein protein. 66 4e-10
BC006984-1|AAH06984.1| 512|Homo sapiens Unknown (protein for IM... 66 4e-10
AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-... 66 4e-10
AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-... 66 4e-10
AK024959-1|BAB15043.1| 696|Homo sapiens protein ( Homo sapiens ... 66 4e-10
AB209625-1|BAD92862.1| 459|Homo sapiens dynactin 1 isoform 1 va... 66 4e-10
AB111886-1|BAC98374.1| 1571|Homo sapiens KIAA2034 protein protein. 66 4e-10
AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein. 66 4e-10
AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein. 66 4e-10
U53445-1|AAA98972.1| 752|Homo sapiens DOC1 protein. 66 5e-10
BC129803-1|AAI29804.1| 638|Homo sapiens MYH14 protein protein. 66 5e-10
BC108904-1|AAI08905.1| 725|Homo sapiens hyaluronan-mediated mot... 66 5e-10
BC070281-1|AAH70281.1| 552|Homo sapiens HMMR protein protein. 66 5e-10
BC051911-1|AAH51911.1| 757|Homo sapiens chromosome 13 open read... 66 5e-10
BC050058-1|AAH50058.1| 703|Homo sapiens Unknown (protein for MG... 66 5e-10
AL391384-3|CAI15673.1| 757|Homo sapiens RP11-505F3.1 protein. 66 5e-10
AL354720-1|CAI14869.1| 757|Homo sapiens RP11-505F3.1 protein. 66 5e-10
M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myo... 65 7e-10
D63997-1|BAA23661.1| 1530|Homo sapiens GCP170 protein. 65 7e-10
BC125087-1|AAI25088.1| 568|Homo sapiens CCDC41 protein protein. 65 7e-10
AC002563-2|AAB71327.1| 1286|Homo sapiens WUGSC:H_127H14.1 protein. 65 7e-10
AB027133-1|BAB71953.1| 1390|Homo sapiens male enhanced antigen-2... 65 7e-10
L06148-1|AAA35921.1| 579|Homo sapiens golgin-165 protein. 65 1e-09
D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein. 65 1e-09
BC131805-1|AAI31806.1| 913|Homo sapiens CCDC46 protein protein. 65 1e-09
AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit S... 65 1e-09
AL031283-6|CAI21428.1| 692|Homo sapiens forkhead-associated (FH... 65 1e-09
AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant... 65 1e-09
AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant... 65 1e-09
AF330046-1|AAL37481.1| 757|Homo sapiens progesterone-induced bl... 64 1e-09
AB067524-1|BAB67830.1| 704|Homo sapiens KIAA1937 protein protein. 64 1e-09
AB058696-1|BAB47422.1| 1270|Homo sapiens KIAA1793 protein protein. 64 1e-09
X98801-1|CAA67333.1| 1263|Homo sapiens dynactin protein. 64 2e-09
BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein. 64 2e-09
BC111801-1|AAI11802.1| 703|Homo sapiens ROCK2 protein protein. 64 2e-09
BC091490-1|AAH91490.1| 620|Homo sapiens ODF2L protein protein. 64 2e-09
AL627308-5|CAH71336.1| 1732|Homo sapiens CDC42 binding protein k... 64 2e-09
AL627308-3|CAH71337.1| 1719|Homo sapiens CDC42 binding protein k... 64 2e-09
AL589649-3|CAH71820.1| 1213|Homo sapiens filamin A interacting p... 64 2e-09
AL589649-1|CAH71818.1| 1114|Homo sapiens filamin A interacting p... 64 2e-09
AL451047-3|CAH71185.1| 1732|Homo sapiens CDC42 binding protein k... 64 2e-09
AL451047-1|CAH71183.1| 1719|Homo sapiens CDC42 binding protein k... 64 2e-09
AL445465-2|CAH73615.1| 1213|Homo sapiens filamin A interacting p... 64 2e-09
AL445465-1|CAH73614.1| 1114|Homo sapiens filamin A interacting p... 64 2e-09
AL353689-9|CAI19109.1| 1732|Homo sapiens CDC42 binding protein k... 64 2e-09
AL353689-7|CAI19108.1| 1719|Homo sapiens CDC42 binding protein k... 64 2e-09
AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein. 64 2e-09
AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,... 64 2e-09
AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,... 64 2e-09
AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens ... 64 2e-09
AK056465-1|BAB71192.1| 703|Homo sapiens protein ( Homo sapiens ... 64 2e-09
AJ518975-1|CAD57745.1| 1719|Homo sapiens CDC42 binding protein k... 64 2e-09
AF254756-1|AAK13079.1| 698|Homo sapiens predicted testis protei... 64 2e-09
AF086947-1|AAD03694.1| 1261|Homo sapiens dynactin 1 protein. 64 2e-09
AF064205-2|AAD55812.1| 1144|Homo sapiens dynactin 1 p135 isoform... 64 2e-09
AF064205-1|AAD55811.1| 1278|Homo sapiens dynactin 1 p150 isoform... 64 2e-09
AC019097-1|AAY14820.1| 698|Homo sapiens unknown protein. 64 2e-09
AB208968-1|BAD92205.1| 1702|Homo sapiens CDC42 binding protein k... 64 2e-09
AB086011-1|BAC77067.1| 1213|Homo sapiens L-FILIP protein. 64 2e-09
AB033101-1|BAA86589.1| 1140|Homo sapiens KIAA1275 protein protein. 64 2e-09
AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein. 64 2e-09
BC127772-1|AAI27773.1| 863|Homo sapiens KIF5C protein protein. 64 2e-09
BC114620-1|AAI14621.1| 1756|Homo sapiens periplakin protein. 64 2e-09
BC110287-1|AAI10288.1| 725|Homo sapiens KIF5C protein protein. 64 2e-09
BC041806-1|AAH41806.1| 698|Homo sapiens C13orf24 protein protein. 64 2e-09
BC023634-1|AAH23634.2| 383|Homo sapiens IFT74 protein protein. 64 2e-09
AL451125-2|CAI14346.1| 767|Homo sapiens golgi autoantigen, golg... 64 2e-09
AL354928-1|CAI39632.1| 767|Homo sapiens golgi autoantigen, golg... 64 2e-09
AL133027-1|CAB61359.1| 1033|Homo sapiens hypothetical protein pr... 64 2e-09
AK000283-1|BAA91052.1| 1084|Homo sapiens protein ( Homo sapiens ... 64 2e-09
AF041004-1|AAD17459.1| 1756|Homo sapiens periplakin protein. 64 2e-09
AF013717-1|AAC39668.1| 1756|Homo sapiens periplakin protein. 64 2e-09
AF001691-1|AAC17738.1| 1756|Homo sapiens 195 kDa cornified envel... 64 2e-09
AC108512-1|AAX82030.1| 684|Homo sapiens unknown protein. 64 2e-09
AB011140-1|BAA25494.1| 1426|Homo sapiens KIAA0568 protein protein. 64 2e-09
AB011103-1|BAA25457.2| 999|Homo sapiens KIAA0531 protein protein. 64 2e-09
BC109126-1|AAI09127.1| 872|Homo sapiens chromosome 10 open read... 63 3e-09
BC101470-1|AAI01471.1| 1478|Homo sapiens FYVE and coiled-coil do... 63 3e-09
BC101468-1|AAI01469.1| 1478|Homo sapiens FYVE and coiled-coil do... 63 3e-09
BC071583-1|AAH71583.1| 1139|Homo sapiens DCTN1 protein protein. 63 3e-09
BC060826-1|AAH60826.1| 843|Homo sapiens GOLGA3 protein protein. 63 3e-09
BC036225-1|AAH36225.1| 872|Homo sapiens chromosome 10 open read... 63 3e-09
BC028366-1|AAH28366.1| 698|Homo sapiens testis specific, 10 pro... 63 3e-09
AY359522-1|AAQ57128.1| 657|Homo sapiens hypothetical protein DK... 63 3e-09
AL834265-1|CAD38940.1| 505|Homo sapiens hypothetical protein pr... 63 3e-09
AL590377-2|CAI14630.2| 1406|Homo sapiens chromosome 9 open readi... 63 3e-09
AL445928-1|CAH72248.1| 657|Homo sapiens novel protein protein. 63 3e-09
AL355378-1|CAI15667.1| 872|Homo sapiens novel protein protein. 63 3e-09
AL354738-1|CAI16195.2| 1406|Homo sapiens chromosome 9 open readi... 63 3e-09
AL354711-1|CAH72682.2| 1406|Homo sapiens chromosome 9 open readi... 63 3e-09
AL162742-5|CAI12110.1| 872|Homo sapiens novel protein protein. 63 3e-09
AL162725-3|CAH70424.1| 1406|Homo sapiens chromosome 9 open readi... 63 3e-09
AL133214-3|CAH70743.2| 1406|Homo sapiens chromosome 9 open readi... 63 3e-09
AK127744-1|BAC87110.1| 600|Homo sapiens protein ( Homo sapiens ... 63 3e-09
AK027705-1|BAB55310.1| 965|Homo sapiens protein ( Homo sapiens ... 63 3e-09
AJ292348-1|CAC33883.1| 1478|Homo sapiens FYVE and coiled-coil do... 63 3e-09
AF155115-1|AAD42881.1| 472|Homo sapiens NY-REN-58 antigen protein. 63 3e-09
AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein. 63 3e-09
U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein. 63 4e-09
M21665-1|AAA36345.1| 524|Homo sapiens protein ( Human beta-myos... 63 4e-09
BC114627-1|AAI14628.1| 790|Homo sapiens SLMAP protein protein. 63 4e-09
BC014050-1|AAH14050.1| 495|Homo sapiens centrosomal protein 63k... 63 4e-09
BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein. 63 4e-09
AY014284-1|AAK27309.1| 699|Homo sapiens nucleoporin NYD-SP7 pro... 63 4e-09
AF458591-1|AAM49719.1| 590|Homo sapiens hypothetical protein pr... 63 4e-09
AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein... 63 4e-09
AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein. 63 4e-09
AB014535-1|BAA31610.2| 864|Homo sapiens KIAA0635 protein protein. 63 4e-09
X65873-1|CAA46703.1| 963|Homo sapiens kinesin heavy chain protein. 62 5e-09
X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac m... 62 5e-09
U51587-1|AAB81549.1| 767|Homo sapiens Golgi complex autoantigen... 62 5e-09
BC126281-1|AAI26282.1| 963|Homo sapiens kinesin family member 5... 62 5e-09
BC126279-1|AAI26280.1| 963|Homo sapiens kinesin family member 5... 62 5e-09
BC125086-1|AAI25087.1| 634|Homo sapiens CCDC41 protein protein. 62 5e-09
BC021123-1|AAH21123.2| 987|Homo sapiens sperm antigen with calp... 62 5e-09
AY816328-1|AAW30001.1| 790|Homo sapiens structure protein NSP5b... 62 5e-09
AL161932-2|CAH71618.1| 963|Homo sapiens kinesin family member 5... 62 5e-09
AL139008-2|CAM15100.1| 1011|Homo sapiens ankyrin repeat domain 1... 62 5e-09
AB041533-1|BAB16440.1| 759|Homo sapiens sperm antigen protein. 62 5e-09
BC032853-1|AAH32853.1| 767|Homo sapiens golgi autoantigen, golg... 62 7e-09
AK093285-1|BAC04121.1| 797|Homo sapiens protein ( Homo sapiens ... 62 7e-09
L16782-1|AAC37542.1| 566|Homo sapiens putative M phase phosphop... 62 9e-09
D67035-1|BAA22586.1| 973|Homo sapiens SCP-1 protein. 62 9e-09
DQ139275-1|ABA43896.1| 1313|Homo sapiens Tax1-binding protein 2 ... 61 1e-08
BC038515-1|AAH38515.1| 796|Homo sapiens CCDC110 protein protein. 61 1e-08
BC033618-1|AAH33618.1| 481|Homo sapiens SPECC1 protein protein. 61 1e-08
BC028419-1|AAH28419.1| 833|Homo sapiens coiled-coil domain cont... 61 1e-08
BC000280-1|AAH00280.1| 471|Homo sapiens MYH10 protein protein. 61 1e-08
AY816329-1|AAW30002.1| 1068|Homo sapiens structure protein NSP5b... 61 1e-08
AY816327-1|AAW30000.1| 987|Homo sapiens structure protein NSP5a... 61 1e-08
AY816326-1|AAW29999.1| 709|Homo sapiens structure protein NSP5a... 61 1e-08
AK023738-1|BAB14662.1| 475|Homo sapiens protein ( Homo sapiens ... 61 1e-08
AK000990-1|BAA91457.1| 535|Homo sapiens protein ( Homo sapiens ... 61 1e-08
AB080722-1|BAC81776.1| 833|Homo sapiens hypothetical protein pr... 61 1e-08
Z97054-3|CAI42646.1| 1233|Homo sapiens structural maintenance of... 61 2e-08
Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50 p... 61 2e-08
S78271-1|AAB34405.1| 1233|Homo sapiens SB1.8/DXS423E protein. 61 2e-08
M25142-1|AAA60387.1| 389|Homo sapiens myosin heavy chain alpha-... 61 2e-08
D80000-1|BAA11495.2| 1233|Homo sapiens KIAA0178 protein. 61 2e-08
BC112127-1|AAI12128.1| 1233|Homo sapiens SMC1 structural mainten... 61 2e-08
BC048304-1|AAH48304.1| 597|Homo sapiens HOOK3 protein protein. 61 2e-08
AL161779-1|CAI42089.1| 1233|Homo sapiens structural maintenance ... 61 2e-08
AK131080-1|BAC85130.1| 563|Homo sapiens FLJ00279 protein protein. 61 2e-08
BC133019-1|AAI33020.1| 1427|Homo sapiens LOC650001 protein protein. 60 2e-08
BC011615-1|AAH11615.2| 739|Homo sapiens AZI1 protein protein. 60 2e-08
AL833308-1|CAD89924.1| 878|Homo sapiens hypothetical protein pr... 60 2e-08
AK128098-1|BAC87273.1| 1185|Homo sapiens protein ( Homo sapiens ... 60 2e-08
AB029041-1|BAA83070.1| 1165|Homo sapiens KIAA1118 protein protein. 60 2e-08
AB011137-1|BAA25491.2| 641|Homo sapiens KIAA0565 protein protein. 60 2e-08
Y09631-1|CAA70844.1| 758|Homo sapiens PIBF1 protein protein. 60 3e-08
BC115701-1|AAI15702.1| 828|Homo sapiens SLMAP protein protein. 60 3e-08
BC103765-1|AAI03766.1| 691|Homo sapiens NUMA1 protein protein. 60 3e-08
BC056146-1|AAH56146.1| 718|Homo sapiens hook homolog 3 (Drosoph... 60 3e-08
BC027493-1|AAH27493.1| 691|Homo sapiens Unknown (protein for IM... 60 3e-08
BC011621-1|AAH11621.1| 728|Homo sapiens hook homolog 1 (Drosoph... 60 3e-08
AL035416-6|CAI22779.1| 728|Homo sapiens hook homolog 1 (Drosoph... 60 3e-08
AK091549-1|BAC03690.1| 623|Homo sapiens protein ( Homo sapiens ... 60 3e-08
AK024004-1|BAB14769.1| 519|Homo sapiens protein ( Homo sapiens ... 60 3e-08
AF332010-1|AAO32947.1| 676|Homo sapiens CDV-1R variant b protein. 60 3e-08
AF250326-1|AAL50343.1| 676|Homo sapiens CDV-1R protein. 60 3e-08
AF241830-1|AAK29204.1| 718|Homo sapiens golgi-associated microt... 60 3e-08
AF139540-1|AAP97269.1| 676|Homo sapiens CDV protein protein. 60 3e-08
AF044923-1|AAC09298.1| 728|Homo sapiens hook1 protein protein. 60 3e-08
AB028965-1|BAA82994.2| 1019|Homo sapiens KIAA1042 protein protein. 60 3e-08
BC000322-1|AAH00322.1| 1193|Homo sapiens sperm associated antige... 60 4e-08
AL445669-8|CAH70752.1| 783|Homo sapiens novel protein protein. 60 4e-08
AL138788-1|CAI22439.1| 783|Homo sapiens novel protein protein. 60 4e-08
AL137585-1|CAB70827.1| 1027|Homo sapiens hypothetical protein pr... 60 4e-08
AK093227-1|BAC04102.1| 550|Homo sapiens protein ( Homo sapiens ... 60 4e-08
Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein. 59 5e-08
BC101026-1|AAI01027.1| 490|Homo sapiens SASS6 protein protein. 59 5e-08
BC046212-1|AAH46212.1| 364|Homo sapiens Similar to cytomatrix p... 59 5e-08
BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein. 59 5e-08
AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein p... 59 5e-08
AB208841-1|BAD92078.1| 1585|Homo sapiens Nuclear mitotic apparat... 59 5e-08
BC017929-1|AAH17929.1| 399|Homo sapiens CCDC67 protein protein. 59 6e-08
AL833273-1|CAD91152.1| 1509|Homo sapiens hypothetical protein pr... 59 6e-08
AF399910-1|AAK91712.1| 1193|Homo sapiens mitotic spindle associa... 59 6e-08
AF345347-1|AAL06396.2| 1135|Homo sapiens mitotic spindle-associa... 59 6e-08
AF091711-1|AAD39719.1| 1773|Homo sapiens splice variant AKAP350 ... 59 6e-08
AF063308-1|AAD02813.1| 1120|Homo sapiens coiled-coil related pro... 59 6e-08
BC068997-1|AAH68997.1| 541|Homo sapiens centrosomal protein 63k... 58 8e-08
AY651261-1|AAX35689.1| 1244|Homo sapiens centrosomal protein 1 p... 58 8e-08
AY639646-1|AAX19141.1| 572|Homo sapiens prefoldin subunit 6-lik... 58 8e-08
AY165122-1|AAO39147.1| 1995|Homo sapiens myosin heavy chain prot... 58 8e-08
AK023448-1|BAB14578.1| 541|Homo sapiens protein ( Homo sapiens ... 58 8e-08
Z22957-1|CAA80533.1| 812|Homo sapiens myosin I homologue protein. 58 1e-07
BC015922-1|AAH15922.1| 688|Homo sapiens trafficking protein, ki... 58 1e-07
AY237536-1|AAP04413.1| 1401|Homo sapiens KIF27A protein. 58 1e-07
AL354733-4|CAI16013.1| 1401|Homo sapiens kinesin family member 2... 58 1e-07
AL137068-4|CAI12357.1| 994|Homo sapiens centrosomal protein 110... 58 1e-07
AL137068-3|CAI12356.1| 828|Homo sapiens centrosomal protein 110... 58 1e-07
AL133654-1|CAB63770.1| 833|Homo sapiens hypothetical protein pr... 58 1e-07
AK125995-1|BAC86384.1| 842|Homo sapiens protein ( Homo sapiens ... 58 1e-07
AF432211-1|AAL99918.1| 460|Homo sapiens CLL-associated antigen ... 58 1e-07
AF308294-1|AAG48261.1| 312|Homo sapiens serologically defined b... 58 1e-07
Y07759-2|CAA69036.1| 1828|Homo sapiens mysoin heavy chain 12 pro... 58 1e-07
U06698-1|AAA20231.1| 1032|Homo sapiens neuronal kinesin heavy ch... 58 1e-07
BC132717-1|AAI32718.1| 1132|Homo sapiens phosphodiesterase 4D in... 58 1e-07
BC078660-1|AAH78660.1| 1132|Homo sapiens phosphodiesterase 4D in... 58 1e-07
BC060037-1|AAH60037.1| 622|Homo sapiens KIAA1212 protein protein. 58 1e-07
BC043398-1|AAH43398.1| 805|Homo sapiens CEP290 protein protein. 58 1e-07
AL832024-1|CAD89923.1| 988|Homo sapiens hypothetical protein pr... 58 1e-07
AL831815-1|CAD38529.1| 969|Homo sapiens hypothetical protein pr... 58 1e-07
AL590452-8|CAH72528.1| 2240|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL590452-7|CAH72527.1| 988|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL590452-6|CAH72526.1| 969|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL590452-4|CAH72524.1| 2346|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL590452-3|CAH72523.1| 2362|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL590452-2|CAH72522.1| 1132|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL138796-7|CAI22827.1| 2240|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL138796-6|CAI22826.1| 988|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL138796-5|CAI22825.1| 969|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL138796-4|CAI22824.1| 2346|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL138796-3|CAI22823.1| 2362|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AL138796-2|CAI22822.1| 1132|Homo sapiens phosphodiesterase 4D in... 58 1e-07
AK027881-1|BAB55428.1| 690|Homo sapiens protein ( Homo sapiens ... 58 1e-07
AF273044-1|AAG34904.1| 761|Homo sapiens CTCL tumor antigen se2-... 58 1e-07
AB209505-1|BAD92742.1| 1409|Homo sapiens Myosin Va variant protein. 58 1e-07
AB209487-1|BAD92724.1| 1409|Homo sapiens Myosin Va variant protein. 58 1e-07
AB051551-1|BAB21855.1| 1029|Homo sapiens KIAA1764 protein protein. 58 1e-07
AB007946-1|BAA32322.2| 1148|Homo sapiens KIAA0477 protein protein. 58 1e-07
AB007923-1|BAA32299.2| 2296|Homo sapiens KIAA0454 protein protein. 58 1e-07
X97053-1|CAA65765.1| 566|Homo sapiens plectin protein. 57 2e-07
BC130385-1|AAI30386.1| 1197|Homo sapiens structural maintenance ... 57 2e-07
BC012568-1|AAH12568.1| 605|Homo sapiens coiled-coil domain cont... 57 2e-07
BC003177-1|AAH03177.1| 691|Homo sapiens calcium binding and coi... 57 2e-07
AY563137-1|AAT68474.1| 691|Homo sapiens calphoglin protein. 57 2e-07
AY517557-1|AAT44530.1| 605|Homo sapiens hypothetical rhabdomyos... 57 2e-07
AY358397-1|AAQ88763.1| 691|Homo sapiens EESP2436 protein. 57 2e-07
AL354938-1|CAI16923.1| 1197|Homo sapiens structural maintenance ... 57 2e-07
AL161791-1|CAI16866.1| 1197|Homo sapiens structural maintenance ... 57 2e-07
AK056756-1|BAB71273.1| 376|Homo sapiens protein ( Homo sapiens ... 57 2e-07
AF265230-1|AAK58539.1| 975|Homo sapiens RING finger protein 20 ... 57 2e-07
AB040969-1|BAA96060.1| 645|Homo sapiens KIAA1536 protein protein. 57 2e-07
X04201-1|CAA27798.1| 285|Homo sapiens protein ( Human skeletal ... 57 3e-07
BC110585-1|AAI10586.1| 975|Homo sapiens ring finger protein 20 ... 57 3e-07
>AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein.
Length = 1088
Score = 101 bits (243), Expect = 7e-21
Identities = 117/527 (22%), Positives = 236/527 (44%), Gaps = 23/527 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KNKI + + +D E+ + Q D K I L+E L + +
Sbjct: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 496
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMIN--DMRSRIIE-LEKKCEALD 211
D + + + +N + A + GT A ++ + + D++ R + L+KK E L
Sbjct: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 556
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K +
Sbjct: 557 EQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ 616
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQMLKEKCEA 328
YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+ LK A
Sbjct: 617 EEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSRLKTLEIA 674
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
LEQ + + +M+++L++ E+A E E+ +R Q ++ ++ + +
Sbjct: 675 LEQKKEECL----KMESQLKKAHEAALEARASPEM--SDRIQHLEREITRYKDESSKAQA 728
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-LSTEKFNFIEEIKTLKD-ELIEKTIN 445
E+ L L N+ +D +++ L + KD+ E+++ K +++E+
Sbjct: 729 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARR 788
Query: 446 YENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLR---LRESDSELEQLEDQVQM 501
E+ N + ++ ++++K ++ E R+ V + R L + +S E QV+
Sbjct: 789 REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 848
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIES 561
L A E ++ EL + K L++T + E + L N L+++ E M+ L
Sbjct: 849 LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEALLAAI 907
Query: 562 LQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 954
Score = 42.7 bits (96), Expect = 0.004
Identities = 76/333 (22%), Positives = 139/333 (41%), Gaps = 51/333 (15%)
Query: 296 ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE---- 351
+S +L+ + +I L+ Q LKE + L + +KE ++ + + I+
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
Query: 352 -----ESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
E A K + +I ++E+ + +QE + TIQ L+ E++ ++ L+ Q+S
Sbjct: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDS 250
Query: 406 DLKQELNNLKNCKDELSTEKFNFI--------EEIKTLKDELIEKTINYENEKNKLNL-- 455
+ + C EL+ E F + +E+ L+ L E + E +K LN
Sbjct: 251 SSRTG----EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 456 -AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL----- 509
+++K ++ S T + H T RL E++ + LE ++ +L
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEE-DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 510 ---ENELTTYKNTLNNTVRECDEYK-----------EALVNILKSKAALTKEHTRIMEHN 555
EN + K TV E + K E + +LKS AL+ E E
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEE 422
Query: 556 VTLIESLQNVEKEAYRELGTIKNELI-EDVELL 587
+ +E ++ K ++G +K EL +D ELL
Sbjct: 423 MKQMEVYRSHSKFMKNKIGQVKQELSRKDTELL 455
>AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein.
Length = 992
Score = 101 bits (242), Expect = 9e-21
Identities = 119/532 (22%), Positives = 238/532 (44%), Gaps = 29/532 (5%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KNKI + + +D E+ + Q D K I L+E L + +
Sbjct: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 496
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMIN--DMRSRIIE-LEKKCEALD 211
D + + + +N + A + GT A ++ + + D++ R + L+KK E L
Sbjct: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 556
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K +
Sbjct: 557 EQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ 616
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQMLKEKCEA 328
YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+ LK A
Sbjct: 617 EEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSRLKTLEIA 674
Query: 329 LEQLHSQLIIKEQEMK----AKLE-QIEESASEKLKICE---IQFEERSQSIQEHCSQQE 380
LEQ + + E ++K A LE + S++++ E ++++ S Q +
Sbjct: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 734
Query: 381 KTIQYLEQE----IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
+ ++ +E E K++ LT+ Q D +++ NLK+ + + +EE + +
Sbjct: 735 EILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 794
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
D L + + ++ K + +E+ ++E + ++ R++V L + +S E
Sbjct: 795 DNLNDSSQQLQDSLRKKDDRIEE-LEEALRESVQITAEREMV------LAQEESARTNAE 847
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
QV+ L A E ++ EL + K L++T + E + L N L+++ E M+
Sbjct: 848 KQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEA 906
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
L + A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 907 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 958
Score = 42.7 bits (96), Expect = 0.004
Identities = 76/333 (22%), Positives = 139/333 (41%), Gaps = 51/333 (15%)
Query: 296 ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE---- 351
+S +L+ + +I L+ Q LKE + L + +KE ++ + + I+
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
Query: 352 -----ESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
E A K + +I ++E+ + +QE + TIQ L+ E++ ++ L+ Q+S
Sbjct: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDS 250
Query: 406 DLKQELNNLKNCKDELSTEKFNFI--------EEIKTLKDELIEKTINYENEKNKLNL-- 455
+ + C EL+ E F + +E+ L+ L E + E +K LN
Sbjct: 251 SSRTG----EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 456 -AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL----- 509
+++K ++ S T + H T RL E++ + LE ++ +L
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEE-DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 510 ---ENELTTYKNTLNNTVRECDEYK-----------EALVNILKSKAALTKEHTRIMEHN 555
EN + K TV E + K E + +LKS AL+ E E
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEE 422
Query: 556 VTLIESLQNVEKEAYRELGTIKNELI-EDVELL 587
+ +E ++ K ++G +K EL +D ELL
Sbjct: 423 MKQMEVYRSHSKFMKNKIGQVKQELSRKDTELL 455
>AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein.
Length = 1003
Score = 101 bits (242), Expect = 9e-21
Identities = 119/532 (22%), Positives = 238/532 (44%), Gaps = 29/532 (5%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KNKI + + +D E+ + Q D K I L+E L + +
Sbjct: 448 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 507
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMIN--DMRSRIIE-LEKKCEALD 211
D + + + +N + A + GT A ++ + + D++ R + L+KK E L
Sbjct: 508 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 567
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K +
Sbjct: 568 EQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ 627
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQMLKEKCEA 328
YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+ LK A
Sbjct: 628 EEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSRLKTLEIA 685
Query: 329 LEQLHSQLIIKEQEMK----AKLE-QIEESASEKLKICE---IQFEERSQSIQEHCSQQE 380
LEQ + + E ++K A LE + S++++ E ++++ S Q +
Sbjct: 686 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 745
Query: 381 KTIQYLEQE----IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
+ ++ +E E K++ LT+ Q D +++ NLK+ + + +EE + +
Sbjct: 746 EILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 805
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
D L + + ++ K + +E+ ++E + ++ R++V L + +S E
Sbjct: 806 DNLNDSSQQLQDSLRKKDDRIEE-LEEALRESVQITAEREMV------LAQEESARTNAE 858
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
QV+ L A E ++ EL + K L++T + E + L N L+++ E M+
Sbjct: 859 KQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEA 917
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
L + A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 918 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 969
Score = 42.7 bits (96), Expect = 0.004
Identities = 76/333 (22%), Positives = 139/333 (41%), Gaps = 51/333 (15%)
Query: 296 ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE---- 351
+S +L+ + +I L+ Q LKE + L + +KE ++ + + I+
Sbjct: 144 VSMASTVPHSLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 202
Query: 352 -----ESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
E A K + +I ++E+ + +QE + TIQ L+ E++ ++ L+ Q+S
Sbjct: 203 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDS 261
Query: 406 DLKQELNNLKNCKDELSTEKFNFI--------EEIKTLKDELIEKTINYENEKNKLNL-- 455
+ + C EL+ E F + +E+ L+ L E + E +K LN
Sbjct: 262 SSRTG----EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 317
Query: 456 -AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL----- 509
+++K ++ S T + H T RL E++ + LE ++ +L
Sbjct: 318 ESIKKLLEMLQSKGLSAKATEE-DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 376
Query: 510 ---ENELTTYKNTLNNTVRECDEYK-----------EALVNILKSKAALTKEHTRIMEHN 555
EN + K TV E + K E + +LKS AL+ E E
Sbjct: 377 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEE 433
Query: 556 VTLIESLQNVEKEAYRELGTIKNELI-EDVELL 587
+ +E ++ K ++G +K EL +D ELL
Sbjct: 434 MKQMEVYRSHSKFMKNKIGQVKQELSRKDTELL 466
>BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 100 bits (240), Expect = 2e-20
Identities = 120/529 (22%), Positives = 242/529 (45%), Gaps = 33/529 (6%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ---EILKELATKFRQSHNNIDFN 158
Q E+ Q + E+ KD + ++E N+ + + E+LKE T ++ I
Sbjct: 465 QAEIGQVKQ-ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA-KEQRAAILQT 522
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQ------GTDAEKVSAMIN--DMRSRIIE-LEKKCEA 209
E+D +L T + + +Q GT A ++ + + D++ R + L+KK E
Sbjct: 523 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA 269
L ++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K
Sbjct: 583 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQMLKEKC 326
+ YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+ LK
Sbjct: 643 KQEEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSRLKTLE 700
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
ALEQ + + +M+++L++ E+A E E+ +R Q ++ ++ +
Sbjct: 701 IALEQKKEECL----KMESQLKKAHEAALEARASPEM--SDRIQHLEREITRYKDESSKA 754
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-LSTEKFNFIEEIKTLKD-ELIEKT 443
+ E+ L L N+ +D +++ L + KD+ E+++ K +++E+
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 444 INYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLR---LRESDSELEQLEDQV 499
E+ N + ++ ++++K ++ E R+ V + R L + +S E QV
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
+ L A E ++ EL + K L++T + E + L N L+++ E M+ L
Sbjct: 875 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEALLA 933
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 934 AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 982
Score = 76.6 bits (180), Expect = 3e-13
Identities = 102/527 (19%), Positives = 226/527 (42%), Gaps = 43/527 (8%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNN--IDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
IE ++I+ ++ L++L + + +N + E + ++ ++ + + H+
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV-----YRSHSKFMKN 438
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
E++ ++ ++ EL+KK L E+ + ELS +D+ LQ KL +
Sbjct: 439 KVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR-------KDTELLALQTKLET 491
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE 304
++++Q +E++K +L A E + E++AL+ +L EEK+ +++K
Sbjct: 492 LTNQFSDSKQHIEVLKE----SLTAKEQRAAILQTEVDALRLRL-EEKETMLNK------ 540
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQE---MKAKLEQIEESASEKLKIC 361
KTK + K E + L L +KE++ ++ K+E ++E +K K
Sbjct: 541 --KTKQIQDMAEEKGTQAGE----IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD-LTNNQNSDLKQELNNLKNCKDE 420
+ER +S+Q + + + LE+ + E + T++ L ++ D +++ + N K +
Sbjct: 595 S-SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 653
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVH 479
L K E++ L+ +L EK + + K + +K+ ++ +T +++ +
Sbjct: 654 LKDLK----EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAK-EVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
L + + + LE + S + + LE E+T YK+ + E D E L +
Sbjct: 710 CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL 598
K K+ + + + N++ + E +++E+ + N + L
Sbjct: 770 NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK-SAQMLEEARRREDNLNDSSQQL 828
Query: 599 REEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE 645
++ + KK E ++LAQ + + E + E
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVE 875
Score = 66.5 bits (155), Expect = 3e-10
Identities = 112/517 (21%), Positives = 214/517 (41%), Gaps = 62/517 (11%)
Query: 132 NEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
N I LQ LKE+ + N++ +++ K SKL + + T + +K A
Sbjct: 149 NTIMDLQTQLKEVLRE-----NDLLRKDVEVKESKLSSSMNSIKT----FWSPELKKERA 199
Query: 192 MINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN--ELTL 249
+ D S+I +++ + E QM + +L++ + ++ L + Q+ +S E +
Sbjct: 200 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCV 259
Query: 250 AE-TQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAI---------- 295
AE T++ + + H + +R+ E ++ +E K L+ ++I
Sbjct: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
Query: 296 -ISKCKVDQENLKTK-------HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK- 346
+S ++++ +T+ H +ESL Q KE E++H + K K
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQ 403
L+ + E K+ E + + IQ S + + E+E+K+++ N+
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK 439
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL++ + +EL + EI +K EL K + KL +
Sbjct: 440 VEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDS 499
Query: 464 KNKFET---SL-------SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
K E SL ++ + V L LRL E ++ L + Q+Q + K E+
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEA 569
K+ L + KE VN+L+ K +E R E ++ ++SLQ
Sbjct: 560 HDLKDML--------DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT 611
Query: 570 YRELGTIKNELIE---DVELLKKESNSQIKFLREEVE 603
L T++ L E +E LK++ + + +EE++
Sbjct: 612 DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID 648
Score = 44.8 bits (101), Expect = 0.001
Identities = 69/336 (20%), Positives = 147/336 (43%), Gaps = 34/336 (10%)
Query: 296 ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE---- 351
+S +L+ + +I L+ Q LKE + L + +KE ++ + + I+
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
Query: 352 -----ESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
E A K + +I ++E+ + +QE + TIQ L+ E++ ++ L+ Q+S
Sbjct: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDS 250
Query: 406 DLKQELNNLKNCKDELSTEKFNFI--------EEIKTLKDELIEKTINYENEKNKLNL-- 455
+ + C EL+ E F + +E+ L+ L E + E +K LN
Sbjct: 251 SSRTG----EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 456 -AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL- 513
+++K ++ S T + H T RL E++ + LE ++ +L E+
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEE-DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 514 TTYKNTLNN----TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
++N ++ ++ E K++ ++ ++ +E ++++ N L + E +
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+ + VE LK+E +S+ + EE++KK
Sbjct: 426 MEVYRSHSKFMKNKVEQLKEELSSK-EAQWEELKKK 460
>BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 100 bits (240), Expect = 2e-20
Identities = 120/529 (22%), Positives = 242/529 (45%), Gaps = 33/529 (6%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ---EILKELATKFRQSHNNIDFN 158
Q E+ Q + E+ KD + ++E N+ + + E+LKE T ++ I
Sbjct: 465 QAEIGQVKQ-ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA-KEQRAAILQT 522
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQ------GTDAEKVSAMIN--DMRSRIIE-LEKKCEA 209
E+D +L T + + +Q GT A ++ + + D++ R + L+KK E
Sbjct: 523 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA 269
L ++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K
Sbjct: 583 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQMLKEKC 326
+ YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+ LK
Sbjct: 643 KQEEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSRLKTLE 700
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
ALEQ + + +M+++L++ E+A E E+ +R Q ++ ++ +
Sbjct: 701 IALEQKKEECL----KMESQLKKAHEAALEARASPEM--SDRIQHLEREITRYKDESSKA 754
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-LSTEKFNFIEEIKTLKD-ELIEKT 443
+ E+ L L N+ +D +++ L + KD+ E+++ K +++E+
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 444 INYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLR---LRESDSELEQLEDQV 499
E+ N + ++ ++++K ++ E R+ V + R L + +S E QV
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
+ L A E ++ EL + K L++T + E + L N L+++ E M+ L
Sbjct: 875 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEALLA 933
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 934 AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 982
Score = 76.6 bits (180), Expect = 3e-13
Identities = 102/527 (19%), Positives = 226/527 (42%), Gaps = 43/527 (8%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNN--IDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
IE ++I+ ++ L++L + + +N + E + ++ ++ + + H+
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV-----YRSHSKFMKN 438
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
E++ ++ ++ EL+KK L E+ + ELS +D+ LQ KL +
Sbjct: 439 KVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR-------KDTELLALQTKLET 491
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE 304
++++Q +E++K +L A E + E++AL+ +L EEK+ +++K
Sbjct: 492 LTNQFSDSKQHIEVLKE----SLTAKEQRAAILQTEVDALRLRL-EEKETMLNK------ 540
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQE---MKAKLEQIEESASEKLKIC 361
KTK + K E + L L +KE++ ++ K+E ++E +K K
Sbjct: 541 --KTKQIQDMAEEKGTQAGE----IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD-LTNNQNSDLKQELNNLKNCKDE 420
+ER +S+Q + + + LE+ + E + T++ L ++ D +++ + N K +
Sbjct: 595 S-SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 653
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVH 479
L K E++ L+ +L EK + + K + +K+ ++ +T +++ +
Sbjct: 654 LKDLK----EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAK-EVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
L + + + LE + S + + LE E+T YK+ + E D E L +
Sbjct: 710 CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL 598
K K+ + + + N++ + E +++E+ + N + L
Sbjct: 770 NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK-SAQMLEEARRREDNLNDSSQQL 828
Query: 599 REEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE 645
++ + KK E ++LAQ + + E + E
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVE 875
Score = 66.5 bits (155), Expect = 3e-10
Identities = 112/517 (21%), Positives = 214/517 (41%), Gaps = 62/517 (11%)
Query: 132 NEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
N I LQ LKE+ + N++ +++ K SKL + + T + +K A
Sbjct: 149 NTIMDLQTQLKEVLRE-----NDLLRKDVEVKESKLSSSMNSIKT----FWSPELKKERA 199
Query: 192 MINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN--ELTL 249
+ D S+I +++ + E QM + +L++ + ++ L + Q+ +S E +
Sbjct: 200 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCV 259
Query: 250 AE-TQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAI---------- 295
AE T++ + + H + +R+ E ++ +E K L+ ++I
Sbjct: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
Query: 296 -ISKCKVDQENLKTK-------HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK- 346
+S ++++ +T+ H +ESL Q KE E++H + K K
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQ 403
L+ + E K+ E + + IQ S + + E+E+K+++ N+
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK 439
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL++ + +EL + EI +K EL K + KL +
Sbjct: 440 VEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDS 499
Query: 464 KNKFET---SL-------SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
K E SL ++ + V L LRL E ++ L + Q+Q + K E+
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEA 569
K+ L + KE VN+L+ K +E R E ++ ++SLQ
Sbjct: 560 HDLKDML--------DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT 611
Query: 570 YRELGTIKNELIE---DVELLKKESNSQIKFLREEVE 603
L T++ L E +E LK++ + + +EE++
Sbjct: 612 DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID 648
Score = 44.8 bits (101), Expect = 0.001
Identities = 69/336 (20%), Positives = 147/336 (43%), Gaps = 34/336 (10%)
Query: 296 ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE---- 351
+S +L+ + +I L+ Q LKE + L + +KE ++ + + I+
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
Query: 352 -----ESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
E A K + +I ++E+ + +QE + TIQ L+ E++ ++ L+ Q+S
Sbjct: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDS 250
Query: 406 DLKQELNNLKNCKDELSTEKFNFI--------EEIKTLKDELIEKTINYENEKNKLNL-- 455
+ + C EL+ E F + +E+ L+ L E + E +K LN
Sbjct: 251 SSRTG----EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 456 -AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL- 513
+++K ++ S T + H T RL E++ + LE ++ +L E+
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEE-DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 514 TTYKNTLNN----TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
++N ++ ++ E K++ ++ ++ +E ++++ N L + E +
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+ + VE LK+E +S+ + EE++KK
Sbjct: 426 MEVYRSHSKFMKNKVEQLKEELSSK-EAQWEELKKK 460
>AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein.
Length = 1116
Score = 100 bits (240), Expect = 2e-20
Identities = 120/529 (22%), Positives = 242/529 (45%), Gaps = 33/529 (6%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ---EILKELATKFRQSHNNIDFN 158
Q E+ Q + E+ KD + ++E N+ + + E+LKE T ++ I
Sbjct: 465 QAEIGQVKQ-ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA-KEQRAAILQT 522
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQ------GTDAEKVSAMIN--DMRSRIIE-LEKKCEA 209
E+D +L T + + +Q GT A ++ + + D++ R + L+KK E
Sbjct: 523 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA 269
L ++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K
Sbjct: 583 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQMLKEKC 326
+ YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+ LK
Sbjct: 643 KQEEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSRLKTLE 700
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
ALEQ + + +M+++L++ E+A E E+ +R Q ++ ++ +
Sbjct: 701 IALEQKKEECL----KMESQLKKAHEAALEARASPEM--SDRIQHLEREITRYKDESSKA 754
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-LSTEKFNFIEEIKTLKD-ELIEKT 443
+ E+ L L N+ +D +++ L + KD+ E+++ K +++E+
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 444 INYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLR---LRESDSELEQLEDQV 499
E+ N + ++ ++++K ++ E R+ V + R L + +S E QV
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
+ L A E ++ EL + K L++T + E + L N L+++ E M+ L
Sbjct: 875 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEALLA 933
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 934 AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 982
Score = 76.6 bits (180), Expect = 3e-13
Identities = 102/527 (19%), Positives = 226/527 (42%), Gaps = 43/527 (8%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNN--IDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
IE ++I+ ++ L++L + + +N + E + ++ ++ + + H+
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV-----YRSHSKFMKN 438
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
E++ ++ ++ EL+KK L E+ + ELS +D+ LQ KL +
Sbjct: 439 KVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR-------KDTELLALQTKLET 491
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE 304
++++Q +E++K +L A E + E++AL+ +L EEK+ +++K
Sbjct: 492 LTNQFSDSKQHIEVLKE----SLTAKEQRAAILQTEVDALRLRL-EEKETMLNK------ 540
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQE---MKAKLEQIEESASEKLKIC 361
KTK + K E + L L +KE++ ++ K+E ++E +K K
Sbjct: 541 --KTKQIQDMAEEKGTQAGE----IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD-LTNNQNSDLKQELNNLKNCKDE 420
+ER +S+Q + + + LE+ + E + T++ L ++ D +++ + N K +
Sbjct: 595 S-SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 653
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVH 479
L K E++ L+ +L EK + + K + +K+ ++ +T +++ +
Sbjct: 654 LKDLK----EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAK-EVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
L + + + LE + S + + LE E+T YK+ + E D E L +
Sbjct: 710 CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL 598
K K+ + + + N++ + E +++E+ + N + L
Sbjct: 770 NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK-SAQMLEEARRREDNLNDSSQQL 828
Query: 599 REEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE 645
++ + KK E ++LAQ + + E + E
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVE 875
Score = 66.5 bits (155), Expect = 3e-10
Identities = 112/517 (21%), Positives = 214/517 (41%), Gaps = 62/517 (11%)
Query: 132 NEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
N I LQ LKE+ + N++ +++ K SKL + + T + +K A
Sbjct: 149 NTIMDLQTQLKEVLRE-----NDLLRKDVEVKESKLSSSMNSIKT----FWSPELKKERA 199
Query: 192 MINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN--ELTL 249
+ D S+I +++ + E QM + +L++ + ++ L + Q+ +S E +
Sbjct: 200 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCV 259
Query: 250 AE-TQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAI---------- 295
AE T++ + + H + +R+ E ++ +E K L+ ++I
Sbjct: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
Query: 296 -ISKCKVDQENLKTK-------HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK- 346
+S ++++ +T+ H +ESL Q KE E++H + K K
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQ 403
L+ + E K+ E + + IQ S + + E+E+K+++ N+
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK 439
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL++ + +EL + EI +K EL K + KL +
Sbjct: 440 VEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDS 499
Query: 464 KNKFET---SL-------SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
K E SL ++ + V L LRL E ++ L + Q+Q + K E+
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEA 569
K+ L + KE VN+L+ K +E R E ++ ++SLQ
Sbjct: 560 HDLKDML--------DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT 611
Query: 570 YRELGTIKNELIE---DVELLKKESNSQIKFLREEVE 603
L T++ L E +E LK++ + + +EE++
Sbjct: 612 DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID 648
Score = 44.8 bits (101), Expect = 0.001
Identities = 69/336 (20%), Positives = 147/336 (43%), Gaps = 34/336 (10%)
Query: 296 ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE---- 351
+S +L+ + +I L+ Q LKE + L + +KE ++ + + I+
Sbjct: 133 VSMASTVPHSLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
Query: 352 -----ESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
E A K + +I ++E+ + +QE + TIQ L+ E++ ++ L+ Q+S
Sbjct: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDS 250
Query: 406 DLKQELNNLKNCKDELSTEKFNFI--------EEIKTLKDELIEKTINYENEKNKLNL-- 455
+ + C EL+ E F + +E+ L+ L E + E +K LN
Sbjct: 251 SSRTG----EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 456 -AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL- 513
+++K ++ S T + H T RL E++ + LE ++ +L E+
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEE-DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 514 TTYKNTLNN----TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
++N ++ ++ E K++ ++ ++ +E ++++ N L + E +
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+ + VE LK+E +S+ + EE++KK
Sbjct: 426 MEVYRSHSKFMKNKVEQLKEELSSK-EAQWEELKKK 460
>X64838-1|CAA46050.1| 1427|Homo sapiens restin protein.
Length = 1427
Score = 99 bits (238), Expect = 3e-20
Identities = 148/692 (21%), Positives = 293/692 (42%), Gaps = 47/692 (6%)
Query: 19 KTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXXXXXXLKFATPKAF 78
K + K L +E+ + + + + K R + + I + ++ K
Sbjct: 631 KVSFSKGLGTETAEF-AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 689
Query: 79 KITKAPNSS---IKKTLTCPKNKILPQ--DELVQAQDVEIRNKD----QTIC-EYNKQIE 128
K+ K +S I+ L +++ L + D L + Q+ EI+ K+ Q C E K I+
Sbjct: 690 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 749
Query: 129 DYKNEIAQLQEILKEL-ATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
++ +++ +E L +L A + S + ++ ++L + E NA ++
Sbjct: 750 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA----ESS 805
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
K S++ +++ R ++L E L K+ +LE+ + + + E+ S +
Sbjct: 806 KASSITRELQGRELKLTNLQENLSEVSQVKE----TLEKELQILKEKFAEASEEAVSVQR 861
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
++ ET +L + + E +R E ++EA + DE ++ +I K K E L+
Sbjct: 862 SMQETVNKLHQKEEQFNMLSSDLEKLR-ENLADMEAKFREKDEREEQLI-KAK---EKLE 916
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQ 364
N E +K M + L +++ +L +KE +E++ KL + E+AS K E
Sbjct: 917 ---NDIAEIMK--MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+ QS QE + E+ + LE+++ +L+ ++ ++NQ +LK + E T+
Sbjct: 972 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA---RYERATSETKTK 1028
Query: 425 KFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
++ + KTL D +K E + L +E+ K+ +K + + D + ++
Sbjct: 1029 HEEILQNLQKTLLD-TEDKLKGAREENSGLLQELEELRKQADKAKAA-QTAEDAMQIMEQ 1086
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
+E L LED Q T+AK L+NEL T K V E ++ KE L +
Sbjct: 1087 MTKEKTETLASLEDTKQ--TNAK--LQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1142
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLRE 600
KE + + + L +++E + ELG ++E+ +L ++ S + L
Sbjct: 1143 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1202
Query: 601 EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE 660
+ + + + + S LL + A+L +L NE SL
Sbjct: 1203 KKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1261
Query: 661 LSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
+ L + +L + V + + K+ L S
Sbjct: 1262 VQTLESDKVKLELKVKNLELQLKENKRQLSSS 1293
Score = 57.6 bits (133), Expect = 1e-07
Identities = 123/585 (21%), Positives = 233/585 (39%), Gaps = 61/585 (10%)
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHT---EHNAVQGTDAEKVSAMI 193
LQE LKE +Q H I+ +R L + + H E D +
Sbjct: 353 LQEALKE-----KQQH--IEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL- 404
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
++ +++ +L EA D E + +L EE V D + +E +T +L ETQ
Sbjct: 405 -ELEAKMDQLRTMVEAADREKVELLNQLE--EEKRKVEDLQFRVEEESITKGDL---ETQ 458
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNAS 313
+LE HA E +S+ E K + + L+ +L++ + A +S+ E
Sbjct: 459 TKLE-----HARIKELEQSLLFE-KTKADKLQRELEDTRVATVSEKSRIME--------- 503
Query: 314 IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+E ++E E +L S + +M L Q S EKL++ + S++
Sbjct: 504 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 563
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDELSTEKFNFIEEI 432
EH +E+T Q +EIK L + + +N LK +L + K D ++ K I
Sbjct: 564 EHFGAREETHQ---KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 620
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSE 491
+ + + E +++ L E A E + +T + R D H + + DSE
Sbjct: 621 ASHQQAMEELKVSFSK-----GLGTETA--EFAELKTQIEKMRLDYQHEIENLQNQQDSE 673
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA-LVNILKSKAALTKEHTR 550
+++ L + L + +N+L + D+ ++ LV + + L + +
Sbjct: 674 RAAHAKEMEAL---RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
Query: 551 IMEHNVTLIESLQNVEK-EAYRELGTIKNELIEDVELLKK---ESNSQIKFLREEVE-KK 605
+ E V + + + + + E + D++ L+K E S++K LR+++E +
Sbjct: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 790
Query: 606 RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR 665
+ + + +R L + +L N E +L EL +L+
Sbjct: 791 KQIKHLEIEKNAESSKASSITRELQGREL----KLTNLQENLSEVSQVKETLEKELQILK 846
Query: 666 QE----NEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSL 706
++ +EE ++KL + EQ LR++L
Sbjct: 847 EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 891
Score = 55.6 bits (128), Expect = 6e-07
Identities = 88/445 (19%), Positives = 178/445 (40%), Gaps = 27/445 (6%)
Query: 282 EALKTKLDEEKQAIISKCKVDQENLK-TKHNASIESL-------KNQMLKEKCEALEQLH 333
EALK K +Q + + E K T H IE +Q + E ++QL
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 334 SQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
+ + ++E L Q+EE EK K+ ++QF +SI + + + +++ IKEL
Sbjct: 415 TMVEAADREKVELLNQLEE---EKRKVEDLQFRVEEESITKGDLETQTKLEHAR--IKEL 469
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ +L + L++EL + + + +++ E+ E E+ K
Sbjct: 470 EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAG 529
Query: 454 NLAVEKAI-KEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
++ + ++ +E + + L VTR D +T + E + +++ L +A E L
Sbjct: 530 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 589
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
E + K+ L + +E + ++ + KSK T I H + E + K
Sbjct: 590 ENESLKSKLEHANKENSD----VIALWKSKL-----ETAIASHQQAMEELKVSFSKGLGT 640
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLA 631
E EL +E ++ + +I+ L+ + + +R +
Sbjct: 641 ETAEFA-ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 699
Query: 632 QAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ 691
+A S+L+ +++ + + E + +E E L +Q+ +ID L+
Sbjct: 700 EAIR--SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 692 SQYTPKSPSVLRKSLKVGKENMQTI 716
++ LRK+ GK M+ +
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKL 782
Score = 35.9 bits (79), Expect = 0.51
Identities = 61/286 (21%), Positives = 114/286 (39%), Gaps = 19/286 (6%)
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
L+ +T + K A+++A+KEK + L RD+ + ++ S + ++E +
Sbjct: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA---EVAKATSHVGEIEQE 391
Query: 499 VQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE-HTRIMEHNVT 557
+ + + EL + L V D K L+N L+ + ++ R+ E ++T
Sbjct: 392 LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT 451
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
++E + E IK EL + + K +++ L+ E+E RV
Sbjct: 452 ----KGDLETQTKLEHARIK-ELEQSLLFEKTKADK----LQRELEDTRV----ATVSEK 498
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
L Q A+L R E+ + SL+ E+S L QE E+T T +
Sbjct: 499 SRIMELEKDLALRVQEVAELRR-RLESNKPAGDVDMSLSLLQEISSL-QEKLEVTRTDHQ 556
Query: 678 QSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
+ K + + + ++ + K+ KEN S L N
Sbjct: 557 REITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN 602
>BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 99 bits (238), Expect = 3e-20
Identities = 148/692 (21%), Positives = 293/692 (42%), Gaps = 47/692 (6%)
Query: 19 KTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXXXXXXLKFATPKAF 78
K + K L +E+ + + + + K R + + I + ++ K
Sbjct: 642 KVSFSKGLGTETAEF-AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 700
Query: 79 KITKAPNSS---IKKTLTCPKNKILPQ--DELVQAQDVEIRNKD----QTIC-EYNKQIE 128
K+ K +S I+ L +++ L + D L + Q+ EI+ K+ Q C E K I+
Sbjct: 701 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 760
Query: 129 DYKNEIAQLQEILKEL-ATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
++ +++ +E L +L A + S + ++ ++L + E NA ++
Sbjct: 761 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA----ESS 816
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
K S++ +++ R ++L E L K+ +LE+ + + + E+ S +
Sbjct: 817 KASSITRELQGRELKLTNLQENLSEVSQVKE----TLEKELQILKEKFAEASEEAVSVQR 872
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
++ ET +L + + E +R E ++EA + DE ++ +I K K E L+
Sbjct: 873 SMQETVNKLHQKEEQFNMLSSDLEKLR-ENLADMEAKFREKDEREEQLI-KAK---EKLE 927
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQ 364
N E +K M + L +++ +L +KE +E++ KL + E+AS K E
Sbjct: 928 ---NDIAEIMK--MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 982
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+ QS QE + E+ + LE+++ +L+ ++ ++NQ +LK + E T+
Sbjct: 983 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA---RYERATSETKTK 1039
Query: 425 KFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
++ + KTL D +K E + L +E+ K+ +K + + D + ++
Sbjct: 1040 HEEILQNLQKTLLD-TEDKLKGAREENSGLLQELEELRKQADKAKAA-QTAEDAMQIMEQ 1097
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
+E L LED Q T+AK L+NEL T K V E ++ KE L +
Sbjct: 1098 MTKEKTETLASLEDTKQ--TNAK--LQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1153
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLRE 600
KE + + + L +++E + ELG ++E+ +L ++ S + L
Sbjct: 1154 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1213
Query: 601 EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE 660
+ + + + + S LL + A+L +L NE SL
Sbjct: 1214 KKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1272
Query: 661 LSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
+ L + +L + V + + K+ L S
Sbjct: 1273 VQTLESDKVKLELKVKNLELQLKENKRQLSSS 1304
Score = 57.2 bits (132), Expect = 2e-07
Identities = 105/535 (19%), Positives = 213/535 (39%), Gaps = 32/535 (5%)
Query: 185 DAEKVSAMINDMRSR-IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT 243
+ E+ A+ D + ++ELE K + L V E L + +DLQ ++
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 244 SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ 303
+T + +Q+ ++ + + + +E + L KTK D+ Q + +V
Sbjct: 447 EESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADK-LQRELEDTRVAT 505
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ K++ +E ++E E +L S + +M L Q S EKL++
Sbjct: 506 VSEKSRI-MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 564
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDELS 422
+ S++EH +E+T Q +EIK L + + +N LK +L + K D ++
Sbjct: 565 DHQREITSLKEHFGAREETHQ---KEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 621
Query: 423 TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR-DIVHVL 481
K I + + + E +++ L E A E + +T + R D H +
Sbjct: 622 LWKSKLETAIASHQQAMEELKVSFSK-----GLGTETA--EFAELKTQIEKMRLDYQHEI 674
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA-LVNILKS 540
+ DSE +++ L + L + +N+L + D+ ++ LV + +
Sbjct: 675 ENLQNQQDSERAAHAKEMEAL---RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 731
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEK-EAYRELGTIKNELIEDVELLKK---ESNSQIK 596
L + ++ E V + + + + + E + D++ L+K E S++K
Sbjct: 732 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 791
Query: 597 FLREEVE-KKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXX 655
LR+++E ++ + + +R L + +L N E
Sbjct: 792 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL----KLTNLQENLSEVSQVKE 847
Query: 656 SLVVELSLLRQE----NEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSL 706
+L EL +L+++ +EE ++KL + EQ LR++L
Sbjct: 848 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 902
Score = 52.8 bits (121), Expect = 4e-06
Identities = 78/410 (19%), Positives = 168/410 (40%), Gaps = 19/410 (4%)
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+H +E+ +Q L+ EA ++ +L+ + +E K K+E ++ E+ I + E++
Sbjct: 401 QHVLELEAKMDQ-LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE-SITKGDLEQK 458
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF 428
SQ I E + +++ IKEL+ +L + L++EL + + +
Sbjct: 459 SQ-ISEDPENTQTKLEHAR--IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMEL 515
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAI-KEKNKFETSLSVTR-DIVHVLTLRLR 486
+++ E+ E E+ K ++ + ++ +E + + L VTR D +T
Sbjct: 516 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 575
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
+ E + +++ L +A E L E + K+ L + +E + ++ + KSK
Sbjct: 576 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD----VIALWKSKL---- 627
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
T I H + E + K E EL +E ++ + +I+ L+ + + +R
Sbjct: 628 -ETAIASHQQAMEELKVSFSKGLGTETAEFA-ELKTQIEKMRLDYQHEIENLQNQQDSER 685
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQ 666
+ +A S+L+ +++ + + E + +
Sbjct: 686 AAHAKEMEALRAKLMKVIKEKENSLEAIR--SKLDKAEDQHLVEMEDTLNKLQEAEIKVK 743
Query: 667 ENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
E E L +Q+ +ID L+ ++ LRK+ GK M+ +
Sbjct: 744 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 793
Score = 40.7 bits (91), Expect = 0.018
Identities = 57/288 (19%), Positives = 114/288 (39%), Gaps = 12/288 (4%)
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
L+ +T + K A+++A+KEK + L RD+ + ++ S + ++E +
Sbjct: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA---EVAKATSHVGEIEQE 391
Query: 499 VQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE-HTRIMEHNVT 557
+ + + EL + L V D K L+N L+ + ++ R+ E ++T
Sbjct: 392 LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT 451
Query: 558 L--IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXX 615
+E + ++ +++ I+++E ++ L+ E+E RV
Sbjct: 452 KGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRV----ATVS 507
Query: 616 XXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
L Q A+L R E+ + SL+ E+S L QE E+T T
Sbjct: 508 EKSRIMELEKDLALRVQEVAELRR-RLESNKPAGDVDMSLSLLQEISSL-QEKLEVTRTD 565
Query: 676 AKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
++ K + + + ++ + K+ KEN S L N
Sbjct: 566 HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN 613
>M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protein-170
alpha-2 protein.
Length = 1392
Score = 99.5 bits (237), Expect = 4e-20
Identities = 148/692 (21%), Positives = 292/692 (42%), Gaps = 47/692 (6%)
Query: 19 KTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXXXXXXLKFATPKAF 78
K + K L +E+ + + + + K R + + I + ++ K
Sbjct: 596 KVSFSKGLGTETAEF-AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 654
Query: 79 KITKAPNSS---IKKTLTCPKNKILPQ--DELVQAQDVEIRNKD----QTIC-EYNKQIE 128
K+ K +S I+ L +++ L + D L + Q+ EI+ K+ Q C E K I+
Sbjct: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 714
Query: 129 DYKNEIAQLQEILKEL-ATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
++ +++ +E L +L A + S + ++ ++L + E NA ++
Sbjct: 715 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA----ESS 770
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
K S++ +++ R ++L E L K+ +LE+ + + + E+ S +
Sbjct: 771 KASSITRELQGRELKLTNLQENLSEVSQVKE----TLEKELQILKEKFAEASEEAVSVQR 826
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
++ ET +L + + E +R E ++EA + DE ++ +I K K E L+
Sbjct: 827 SMQETVNKLHQKEEQFNMLSSDLEKLR-ENLADMEAKFREKDEREEQLI-KAK---EKLE 881
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQ 364
N E +K M + L +++ +L +KE +E++ KL + E+AS K E
Sbjct: 882 ---NDIAEIMK--MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+ QS QE + E+ + LE+++ +L+ ++ ++NQ +LK + E T+
Sbjct: 937 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA---RYERATSETKTK 993
Query: 425 KFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
++ + KTL D +K E + L +E+ K+ K + + D + ++
Sbjct: 994 HEEILQNLQKTLLD-TEDKLKGAREENSGLLQELEELRKQAEKAKAA-QTAEDAMQIMEQ 1051
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
+E L LED Q T+AK L+NEL T K V E ++ KE L +
Sbjct: 1052 MTKEKTETLASLEDTKQ--TNAK--LQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1107
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLRE 600
KE + + + L +++E + ELG ++E+ +L ++ S + L
Sbjct: 1108 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1167
Query: 601 EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE 660
+ + + + + S LL + A+L +L NE SL
Sbjct: 1168 KKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1226
Query: 661 LSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
+ L + +L + V + + K+ L S
Sbjct: 1227 VQTLESDKVKLELKVKNLELQLKENKRQLSSS 1258
Score = 52.8 bits (121), Expect = 4e-06
Identities = 113/548 (20%), Positives = 224/548 (40%), Gaps = 55/548 (10%)
Query: 190 SAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTL 249
+ ++ + SR AL + +KQ + E+++ RD L + K TS+ +
Sbjct: 333 TGLLTETSSRYARKISGTTALQEALKEKQQHI---EQLLAERD-LERAEVAKATSH---V 385
Query: 250 AETQQRLEMVK-GH--HALALEAN-ESIRREYKI---ELEALKTKLDEEKQAIIS-KCKV 301
E +Q L + + GH H L LEA + +R + E L +L+EEK+ + + +V
Sbjct: 386 GEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Query: 302 DQENLK--------TKHNASIESLKNQM---LKEKCEALEQLHSQLIIKEQEMKAKLEQI 350
++E++ + I L+ + ++E E +L S + +M L Q
Sbjct: 446 EEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 505
Query: 351 EESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE 410
S EKL++ + S++EH +E+T Q +EIK L + + +N LK +
Sbjct: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ---KEIKALYTATEKLSKENESLKSK 562
Query: 411 LNNL-KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
L + K D ++ K I + + + E +++ L E A E + +T
Sbjct: 563 LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-----GLGTETA--EFAELKT 615
Query: 470 SLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
+ R D H + + DSE +++ L + L + +N+L + D
Sbjct: 616 QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL---RAKLMKVIKEKENSLEAIRSKLD 672
Query: 529 EYKEA-LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK-EAYRELGTIKNELIEDVEL 586
+ ++ LV + + L + ++ E V + + + + + E + D++
Sbjct: 673 KAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 732
Query: 587 LKK---ESNSQIKFLREEVE-KKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLEN 642
L+K E S++K LR+++E ++ + + +R L + +L N
Sbjct: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL----KLTN 788
Query: 643 ENERYXXXXXXXXSLVVELSLLRQE----NEELTMTVAKQSSIIDKLKKDLEQSQYTPKS 698
E +L EL +L+++ +EE ++KL + EQ
Sbjct: 789 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848
Query: 699 PSVLRKSL 706
LR++L
Sbjct: 849 LEKLRENL 856
Score = 46.4 bits (105), Expect = 4e-04
Identities = 77/406 (18%), Positives = 159/406 (39%), Gaps = 22/406 (5%)
Query: 320 QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ 379
+ LKEK + +EQL ++ ++ E+ + E E L + ++ ++ Q
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQE-LALARDGHDQHVLELEAKMDQL 413
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS----TEKFNFIEEIKTL 435
++ ++E EL L+ + DL+ + K +L +EK +E K L
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
Query: 436 K---DELIEKTINYENEKNKLNLAVEKAI-KEKNKFETSLSVTR-DIVHVLTLRLRESDS 490
E+ E E+ K ++ + ++ +E + + L VTR D +T +
Sbjct: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 533
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E + +++ L +A E L E + K+ L + +E + ++ + KSK T
Sbjct: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD----VIALWKSKL-----ETA 584
Query: 551 IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
I H + E + K E EL +E ++ + +I+ L+ + + +R
Sbjct: 585 IASHQQAMEELKVSFSKGLGTETAEFA-ELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
Query: 611 MXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEE 670
+ +A S+L+ +++ + + E + +E E
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIR--SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
Query: 671 LTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
L +Q+ +ID L+ ++ LRK+ GK M+ +
Sbjct: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 747
>BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 98.7 bits (235), Expect = 6e-20
Identities = 148/692 (21%), Positives = 292/692 (42%), Gaps = 47/692 (6%)
Query: 19 KTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXXXXXXLKFATPKAF 78
K + K L +E+ + + + + K R + + I + ++ K
Sbjct: 642 KVSFSKGLGTETAEF-AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 700
Query: 79 KITKAPNSS---IKKTLTCPKNKILPQ--DELVQAQDVEIRNKD----QTIC-EYNKQIE 128
K+ K +S I+ L +++ L + D L + Q+ EI+ K+ Q C E K I+
Sbjct: 701 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 760
Query: 129 DYKNEIAQLQEILKEL-ATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
++ +++ +E L +L A + S + ++ ++L + E NA ++
Sbjct: 761 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA----ESS 816
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
K S++ +++ R ++L E L K+ +LE+ + + + E+ S +
Sbjct: 817 KASSITRELQGRELKLTNLQENLSEVSQVKE----TLEKELQILKEKFAEASEEAVSVQR 872
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
++ ET +L + + E +R E ++EA + DE ++ +I K K E L+
Sbjct: 873 SMQETVNKLHQKEEQFNMLSSDLEKLR-ENLADMEAKFREKDEREEQLI-KAK---EKLE 927
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQ 364
N E +K M + L +++ +L +KE +E++ KL + E+AS K E
Sbjct: 928 ---NDIAEIMK--MSGDNPSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 982
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+ QS QE + E+ + LE+++ +L+ ++ ++NQ +LK + E T+
Sbjct: 983 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA---RYERATSETKTK 1039
Query: 425 KFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
++ + KTL D +K E + L +E+ K+ K + + D + ++
Sbjct: 1040 HEEILQNLQKTLLD-TEDKLKGAREENSGLLQELEELRKQAEKAKAA-QTAEDAMQIMEQ 1097
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
+E L LED Q T+AK L+NEL T K V E ++ KE L +
Sbjct: 1098 MTKEKTETLASLEDTKQ--TNAK--LQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1153
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLRE 600
KE + + + L +++E + ELG ++E+ +L ++ S + L
Sbjct: 1154 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1213
Query: 601 EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE 660
+ + + + + S LL + A+L +L NE SL
Sbjct: 1214 KKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1272
Query: 661 LSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
+ L + +L + V + + K+ L S
Sbjct: 1273 VQTLESDKVKLELKVKNLELQLKENKRQLSSS 1304
Score = 57.2 bits (132), Expect = 2e-07
Identities = 105/535 (19%), Positives = 213/535 (39%), Gaps = 32/535 (5%)
Query: 185 DAEKVSAMINDMRSR-IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT 243
+ E+ A+ D + ++ELE K + L V E L + +DLQ ++
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 244 SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ 303
+T + +Q+ ++ + + + +E + L KTK D+ Q + +V
Sbjct: 447 EESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADK-LQRELEDTRVAT 505
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ K++ +E ++E E +L S + +M L Q S EKL++
Sbjct: 506 VSEKSRI-MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 564
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDELS 422
+ S++EH +E+T Q +EIK L + + +N LK +L + K D ++
Sbjct: 565 DHQREITSLKEHFGAREETHQ---KEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 621
Query: 423 TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR-DIVHVL 481
K I + + + E +++ L E A E + +T + R D H +
Sbjct: 622 LWKSKLETAIASHQQAMEELKVSFSK-----GLGTETA--EFAELKTQIEKMRLDYQHEI 674
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA-LVNILKS 540
+ DSE +++ L + L + +N+L + D+ ++ LV + +
Sbjct: 675 ENLQNQQDSERAAHAKEMEAL---RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 731
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEK-EAYRELGTIKNELIEDVELLKK---ESNSQIK 596
L + ++ E V + + + + + E + D++ L+K E S++K
Sbjct: 732 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 791
Query: 597 FLREEVE-KKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXX 655
LR+++E ++ + + +R L + +L N E
Sbjct: 792 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL----KLTNLQENLSEVSQVKE 847
Query: 656 SLVVELSLLRQE----NEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSL 706
+L EL +L+++ +EE ++KL + EQ LR++L
Sbjct: 848 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 902
Score = 52.8 bits (121), Expect = 4e-06
Identities = 78/410 (19%), Positives = 168/410 (40%), Gaps = 19/410 (4%)
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+H +E+ +Q L+ EA ++ +L+ + +E K K+E ++ E+ I + E++
Sbjct: 401 QHVLELEAKMDQ-LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE-SITKGDLEQK 458
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF 428
SQ I E + +++ IKEL+ +L + L++EL + + +
Sbjct: 459 SQ-ISEDPENTQTKLEHAR--IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMEL 515
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAI-KEKNKFETSLSVTR-DIVHVLTLRLR 486
+++ E+ E E+ K ++ + ++ +E + + L VTR D +T
Sbjct: 516 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 575
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
+ E + +++ L +A E L E + K+ L + +E + ++ + KSK
Sbjct: 576 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD----VIALWKSKL---- 627
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
T I H + E + K E EL +E ++ + +I+ L+ + + +R
Sbjct: 628 -ETAIASHQQAMEELKVSFSKGLGTETAEFA-ELKTQIEKMRLDYQHEIENLQNQQDSER 685
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQ 666
+ +A S+L+ +++ + + E + +
Sbjct: 686 AAHAKEMEALRAKLMKVIKEKENSLEAIR--SKLDKAEDQHLVEMEDTLNKLQEAEIKVK 743
Query: 667 ENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
E E L +Q+ +ID L+ ++ LRK+ GK M+ +
Sbjct: 744 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 793
Score = 40.7 bits (91), Expect = 0.018
Identities = 57/288 (19%), Positives = 114/288 (39%), Gaps = 12/288 (4%)
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
L+ +T + K A+++A+KEK + L RD+ + ++ S + ++E +
Sbjct: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA---EVAKATSHVGEIEQE 391
Query: 499 VQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE-HTRIMEHNVT 557
+ + + EL + L V D K L+N L+ + ++ R+ E ++T
Sbjct: 392 LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT 451
Query: 558 L--IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXX 615
+E + ++ +++ I+++E ++ L+ E+E RV
Sbjct: 452 KGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRV----ATVS 507
Query: 616 XXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
L Q A+L R E+ + SL+ E+S L QE E+T T
Sbjct: 508 EKSRIMELEKDLALRVQEVAELRR-RLESNKPAGDVDMSLSLLQEISSL-QEKLEVTRTD 565
Query: 676 AKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
++ K + + + ++ + K+ KEN S L N
Sbjct: 566 HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN 613
>BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containing
linker protein 1 protein.
Length = 1392
Score = 97.9 bits (233), Expect = 1e-19
Identities = 148/692 (21%), Positives = 292/692 (42%), Gaps = 47/692 (6%)
Query: 19 KTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXXXXXXLKFATPKAF 78
K + K L +E+ + + + + K R + + I + ++ K
Sbjct: 596 KVSFSKGLGAETAEF-AELKTQIEKMRLDYQHEIENLQNQQNSERAAHAKEMEALRAKLM 654
Query: 79 KITKAPNSS---IKKTLTCPKNKILPQ--DELVQAQDVEIRNKD----QTIC-EYNKQIE 128
K+ K +S I+ L +++ L + D L + Q+ EI+ K+ Q C E K I+
Sbjct: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 714
Query: 129 DYKNEIAQLQEILKEL-ATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
++ ++ +E L +L A + S + ++ ++L + E NA ++
Sbjct: 715 NFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA----ESS 770
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
K S++ +++ R ++L E L K+ +LE+ + + + E+ S +
Sbjct: 771 KASSITRELQGRELKLTNLQENLSEVSQVKE----TLEKELQILKEKFAEASEEAVSVQR 826
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
++ ET +L + + E +R E ++EA + DE ++ +I K K E L+
Sbjct: 827 SMQETVNKLHQKEEQFNMLSSDLEKLR-ENLADMEAKFREKDEREEQLI-KAK---EKLE 881
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQ 364
N E +K M + L +++ +L +KE +E++ KL + E+AS K E
Sbjct: 882 ---NDIAEIMK--MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+ QS QE + E+ + LE+++ +L+ ++ ++NQ +LK + E T+
Sbjct: 937 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA---RYERATSETKTK 993
Query: 425 KFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
++ + KTL D +K E + L +E+ K+ +K + + D + ++
Sbjct: 994 HEEILQNLQKTLLD-TEDKLKGAREENSGLLQELEELRKQADKAKAA-QTAEDAMQIMEQ 1051
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
+E L LED Q T+AK L+NEL T K V E ++ KE L +
Sbjct: 1052 MTKEKTETLASLEDTKQ--TNAK--LQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1107
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLRE 600
KE + + + L +++E + ELG ++E+ +L ++ S + L
Sbjct: 1108 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1167
Query: 601 EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE 660
+ + + + + S LL + A+L +L NE SL
Sbjct: 1168 KKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1226
Query: 661 LSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
+ L + +L + V + + K+ L S
Sbjct: 1227 VQTLESDKVKLELKVKNLELQLKENKRQLSSS 1258
Score = 53.2 bits (122), Expect = 3e-06
Identities = 111/546 (20%), Positives = 221/546 (40%), Gaps = 51/546 (9%)
Query: 190 SAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTL 249
+ ++ + SR AL + +KQ + E+++ RD L + K TS+ +
Sbjct: 333 TGLLTETSSRYARKISGTTALQEALKEKQQHI---EQLLAERD-LERAEVAKATSH---V 385
Query: 250 AETQQRLEMVK-GH--HALALEAN-ESIRREYKI---ELEALKTKLDEEKQAIIS-KCKV 301
E +Q L + + GH H L LEA + +R + E L +L+EEK+ + + +V
Sbjct: 386 GEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Query: 302 DQENLK--------TKHNASIESLKNQM---LKEKCEALEQLHSQLIIKEQEMKAKLEQI 350
++E++ + I L+ + ++E E +L S + +M L Q
Sbjct: 446 EEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 505
Query: 351 EESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE 410
S EKL++ + S++EH +E+T Q +EIK L + + +N LK +
Sbjct: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ---KEIKALYTATEKLSKENESLKSK 562
Query: 411 LNNL-KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE- 468
L + K D ++ K I + + + E +++ L + + K + E
Sbjct: 563 LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSF---SKGLGAETAEFAELKTQIEK 619
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
L +I ++ + E + +++E L + EN L ++ L+ +
Sbjct: 620 MRLDYQHEIENLQNQQNSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 679
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK 588
E +N L+ KE +++ E + ++ + T E + D++ L+
Sbjct: 680 VEMEDTLNKLQEAEIKVKE-LEVLQAKCN--EQTKVIDNFTSQPKAT--EEKLLDLDALR 734
Query: 589 K---ESNSQIKFLREEVE-KKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN 644
K E S++K LR+++E ++ + + +R L + +L N
Sbjct: 735 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL----KLTNLQ 790
Query: 645 ERYXXXXXXXXSLVVELSLLRQE----NEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPS 700
E +L EL +L+++ +EE ++KL + EQ
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850
Query: 701 VLRKSL 706
LR++L
Sbjct: 851 KLRENL 856
Score = 42.7 bits (96), Expect = 0.004
Identities = 76/406 (18%), Positives = 157/406 (38%), Gaps = 22/406 (5%)
Query: 320 QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ 379
+ LKEK + +EQL ++ ++ E+ + E E L + ++ ++ Q
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQE-LALARDGHDQHVLELEAKMDQL 413
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS----TEKFNFIEEIKTL 435
++ ++E EL L+ + DL+ + K +L +EK +E K L
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
Query: 436 K---DELIEKTINYENEKNKLNLAVEKAI-KEKNKFETSLSVTR-DIVHVLTLRLRESDS 490
E+ E E+ K ++ + ++ +E + + L VTR D +T +
Sbjct: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 533
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E + +++ L +A E L E + K+ L + +E + ++ + KSK T
Sbjct: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD----VIALWKSKL-----ETA 584
Query: 551 IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
I H + E + K E EL +E ++ + +I+ L+ + +R
Sbjct: 585 IASHQQAMEELKVSFSKGLGAETAEFA-ELKTQIEKMRLDYQHEIENLQNQQNSERAAHA 643
Query: 611 MXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEE 670
+ +A S+L+ +++ + + E + +E E
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIR--SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
Query: 671 LTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
L +Q+ +ID + ++ LRK+ GK M+ +
Sbjct: 702 LQAKCNEQTKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKL 747
>AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a variant
protein.
Length = 1065
Score = 97.1 bits (231), Expect = 2e-19
Identities = 131/619 (21%), Positives = 264/619 (42%), Gaps = 34/619 (5%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQT--ICEYNKQIEDYKNEIAQLQEILKELATK 147
K L K+ ++E ++++ +E NK+ + I + ++E IA Q+ ++EL
Sbjct: 329 KALYTATEKLSKENESLKSK-LEHANKENSDVIALWKSKLE---TAIASHQQAMEELKVS 384
Query: 148 FRQS--HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK 205
F + +F E+ ++ K+R++ H N D+E+ +A +M + +L K
Sbjct: 385 FSKGLGTETAEFAELKTQIEKMRLDYQ--HEIENLQNQQDSER-AAHAKEMEALRAKLMK 441
Query: 206 KCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ +N + + +L E+ ++ + D+L K LQE E +++ + + +
Sbjct: 442 VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKKEKFAEASEEAVSVQRSMQ 500
Query: 264 ALA--LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK-NQ 320
L E +LE L+ L + + K + +++ +K K + + +
Sbjct: 501 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 560
Query: 321 MLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
M + L +++ +L +KE +E++ KL + E+AS K E + QS QE
Sbjct: 561 MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK 620
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEI-KTLK 436
+ E+ + LE+++ +L+ ++ ++NQ +LK + E T+ ++ + KTL
Sbjct: 621 KHEEEKKELERKLSDLEKKMETSHNQCQELKA---RYERATSETKTKHEEILQNLQKTLL 677
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
D +K E + L +E+ K+ K + + D + ++ +E L LE
Sbjct: 678 D-TEDKLKGAREENSGLLQELEELRKQAEKAKAA-QTAEDAMQIMEQMTKEKTETLASLE 735
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
D Q T+AK L+NEL T K V E ++ KE L + KE + +
Sbjct: 736 DTKQ--TNAK--LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAA 791
Query: 557 TLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXX 613
+ L +++E + ELG ++E+ +L ++ S + L + + + + +
Sbjct: 792 QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADE 851
Query: 614 XXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM 673
S LL + A+L +L NE SL + L + +L +
Sbjct: 852 EKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 910
Query: 674 TVAKQSSIIDKLKKDLEQS 692
V + + K+ L S
Sbjct: 911 KVKNLELQLKENKRQLSSS 929
Score = 62.5 bits (145), Expect = 5e-09
Identities = 130/599 (21%), Positives = 239/599 (39%), Gaps = 59/599 (9%)
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHT---EHNAVQGTDAEKVSAMI 193
LQE LKE +Q H I+ +R L + + H E D +
Sbjct: 104 LQEALKE-----KQQH--IEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL- 155
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
++ +++ +L EA D E + +L EE V D + +E +T +L ETQ
Sbjct: 156 -ELEAKMDQLRTMVEAADREKVELLNQLE--EEKRKVEDLQFRVEEESITKGDL---ETQ 209
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNAS 313
+LE HA E +S+ E K + + L+ +L++ + A +S+ E
Sbjct: 210 TKLE-----HARIKELEQSLLFE-KTKADKLQRELEDTRVATVSEKSRIME--------- 254
Query: 314 IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+E ++E E +L S + +M L Q S EKL++ + S++
Sbjct: 255 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 314
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDELSTEKFNFIEEI 432
EH +E+T Q +EIK L + + +N LK +L + K D ++ K I
Sbjct: 315 EHFGAREETHQ---KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 371
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSE 491
+ + + E +++ L E A E + +T + R D H + + DSE
Sbjct: 372 ASHQQAMEELKVSFSK-----GLGTETA--EFAELKTQIEKMRLDYQHEIENLQNQQDSE 424
Query: 492 ----LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
+++E L + EN L ++ L+ + E +N L+ ++
Sbjct: 425 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEK 484
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE-SNSQIKFLREEVEKKR 606
E V++ S+Q + +++ N L D+E L++ ++ + KF RE+ E++
Sbjct: 485 FAEASEEAVSVQRSMQETVNKLHQKEEQF-NMLSSDLEKLRENLADMEAKF-REKDEREE 542
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE---NERYXXXXXXXXSLVVELSL 663
L + S ++ L+++ +E ER + E +
Sbjct: 543 QLIKAKEKLENDIAEIMKMS----GDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 598
Query: 664 LRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRER 722
Q++ E MTV + S + KK E+ + + S L K ++ Q + ER
Sbjct: 599 FLQKSIE-DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 656
Score = 50.4 bits (115), Expect = 2e-05
Identities = 83/366 (22%), Positives = 163/366 (44%), Gaps = 25/366 (6%)
Query: 70 LKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIED 129
LK +A TK + I + L K + +D+L A++ E Q + E KQ E
Sbjct: 650 LKARYERATSETKTKHEEILQNLQ--KTLLDTEDKLKGARE-ENSGLLQELEELRKQAE- 705
Query: 130 YKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNT-NCHTEHNAVQGTDAEK 188
K + AQ E ++ + + + D K + ++ N + E+N + K
Sbjct: 706 -KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 764
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL-EEVITVRDSLCKDLQEKLTSNEL 247
++ ++ E K+ E L K +LS+L EE + + + L + ++++TS++
Sbjct: 765 SKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS-RDEVTSHQK 823
Query: 248 TLAE----TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ 303
E Q LEM K +A+E K ++ + L EK A + K + +
Sbjct: 824 LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI--SITSALLTEKDAELEKLRNEV 881
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
L+ + NAS +SL + + + E+ +++ +L +K E++ K + + S+S +
Sbjct: 882 TVLRGE-NASAKSLHSVV--QTLES-DKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 937
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN----NQNSDLKQELNNLKNCKD 419
+ER+Q Q+ I L+++ ++LK +++ + N N D +LNN +
Sbjct: 938 DEDERAQESQQMIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGD---DLNNYDSDDQ 994
Query: 420 ELSTEK 425
E ++K
Sbjct: 995 EKQSKK 1000
Score = 35.9 bits (79), Expect = 0.51
Identities = 61/286 (21%), Positives = 114/286 (39%), Gaps = 19/286 (6%)
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
L+ +T + K A+++A+KEK + L RD+ + ++ S + ++E +
Sbjct: 86 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA---EVAKATSHVGEIEQE 142
Query: 499 VQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE-HTRIMEHNVT 557
+ + + EL + L V D K L+N L+ + ++ R+ E ++T
Sbjct: 143 LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT 202
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
++E + E IK EL + + K +++ L+ E+E RV
Sbjct: 203 ----KGDLETQTKLEHARIK-ELEQSLLFEKTKADK----LQRELEDTRV----ATVSEK 249
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
L Q A+L R E+ + SL+ E+S L QE E+T T +
Sbjct: 250 SRIMELEKDLALRVQEVAELRR-RLESNKPAGDVDMSLSLLQEISSL-QEKLEVTRTDHQ 307
Query: 678 QSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
+ K + + + ++ + K+ KEN S L N
Sbjct: 308 REITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN 353
>M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein.
Length = 2871
Score = 96.3 bits (229), Expect = 3e-19
Identities = 149/673 (22%), Positives = 283/673 (42%), Gaps = 49/673 (7%)
Query: 85 NSSIKKTLT-CPKNKILPQDELVQAQDVEI--RNKD--QTICEYNKQIEDYKNEIAQLQE 139
N IK+T+ P IL + V A+ +E+ R+ D + + E K +ED K + +++
Sbjct: 977 NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
Query: 140 ILKELATKFRQSHNNIDFNE-IDRKLSKLRINNTNCHTEHNAVQGT------DAEKVSAM 192
+ +EL + N + N+ +D+ L K + + + +++ D +
Sbjct: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR----DSLCKDLQ---EKLTSN 245
++ +I EL +K L E+ D++ S+E+ + D L K Q E L
Sbjct: 1097 LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ 1156
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
+L + + E + L+ + +REY+ EL ++ +EE + +K + +
Sbjct: 1157 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINI 1216
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
KT +I+ + Q + QL +L + +++K ++ ++ +S L+ E +
Sbjct: 1217 TKT----TIKEISMQKEDDSKNLRNQL-DRLSRENRDLKDEIVRLNDSI---LQATEQRR 1268
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
++Q+ E + EI ELK + + N+ KQ L + + E
Sbjct: 1269 RAEENALQQKACGSEIMQKKQHLEI-ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE- 1326
Query: 426 FNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
IE +K E ++ YENE +K+ N E+ I KN+FET +++T+ +H LT++
Sbjct: 1327 ---IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQ 1383
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL--VNILKSKA 542
E S Q+ LT L E+ KNTL T +E + S+
Sbjct: 1384 KEEDTSGYRA---QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440
Query: 543 ALTKEHTRIMEHNVTLIESLQNVE-KEAYRELG-TI--KNELIEDV-ELLKKESNSQIKF 597
+ K+ + VT + + ++V K++ + TI KN+ IE + +L+ KE+N +
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL 1500
Query: 598 LREEVEKKRVLCEM--XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXX 655
E +RV ++ L + D R+ E
Sbjct: 1501 EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560
Query: 656 SLVVELSLLRQENEE----LTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKE 711
+ + EL L +Q+ EE L T ++ S KL+++LE + + K ++ +L E
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 712 NMQTISPLRERNL 724
+ E +L
Sbjct: 1621 QASIVKKRSEDDL 1633
Score = 73.7 bits (173), Expect = 2e-12
Identities = 127/639 (19%), Positives = 266/639 (41%), Gaps = 55/639 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI-----DFN 158
E+ ++ + +N + +++ D K+EI +L + + + + R++ N +
Sbjct: 1223 EISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS 1282
Query: 159 EIDRKLSKLRINNTNC---HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
EI +K L I +E NA E+ + I D I L+ + + +
Sbjct: 1283 EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 1342
Query: 216 DKQMELSSL-----EEVITVRDSLCKDLQ-EKLTSNELTLAETQQRLEMVKGHHALALEA 269
+ + ELS + EE+I++++ ++ K T ++LT+ Q+ E G+ A
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTM----QKEEDTSGYRAQI--- 1395
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL 329
+++ RE + E +K + Q + +V+++ + K S S + Q L+ + +
Sbjct: 1396 -DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV 1454
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
Q+ ++ ++ K L+ ++ +K K EI ER + + + + K ++
Sbjct: 1455 TQMRTEESVR---YKQSLDDAAKTIQDKNK--EI---ERLKQLIDKETNDRKCLEDENAR 1506
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF--IEEIKTLKDELIEKTINYE 447
++ ++Y L NS + +N LK + EL+ + ++ + + +T+KD+ I + ++
Sbjct: 1507 LQRVQYDLQ---KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR---FQ 1560
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVT-------RDIVHVLTLRLRESDSELEQLEDQVQ 500
N +L L +K +E N+ + + S + + + L+E ++ L Q++
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK---EHTRIMEHNVT 557
+ K+ E++L ++ L+ +RE +E L + AL + + ++
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
E Q ++ R L K E IE ++ L + + L EE+ R+ E
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIE-IERLQSLTENLTKEHLMLEEELRNLRL--EYDDLRRG 1737
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
+ +L S+L+ N R L E LRQE E+ +
Sbjct: 1738 RSEADSDKNATILELR----SQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALE 1793
Query: 678 QSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
S+ I + K Q +S V K L+ K +Q +
Sbjct: 1794 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 1832
Score = 44.8 bits (101), Expect = 0.001
Identities = 66/317 (20%), Positives = 140/317 (44%), Gaps = 27/317 (8%)
Query: 102 QDELVQAQDV---EIRNKDQTICEYNK---QIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+D+L Q +DV +R K +T E + ++E + ++ Q QE +K+ + I
Sbjct: 1630 EDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI 1689
Query: 156 D-----FNEIDRKLSKLRINNTNCHTEHNAVQGT---------DAEKV-SAMINDMRSRI 200
+ NE ++ +L+ N EH ++ D + S +D + I
Sbjct: 1690 EDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI 1749
Query: 201 IELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+EL + + +N + Q ++ L+ E +R + K ++ L ++ Q ++V
Sbjct: 1750 LELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVV 1809
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ--ENLKTKHNASIESL 317
+ +L ++ + + K L+ L+ +L+ K + ++ +V Q E K + +
Sbjct: 1810 QERESLLVKIK--VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 1867
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K Q +++ EA+ ++ S+ E+E + +IE +E +I E + S +E S
Sbjct: 1868 KTQYSRKE-EAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
Query: 378 QQEKTIQYLEQEIKELK 394
Q E ++EI +L+
Sbjct: 1927 QLETERSRYQREIDKLR 1943
>AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein.
Length = 2871
Score = 96.3 bits (229), Expect = 3e-19
Identities = 149/673 (22%), Positives = 283/673 (42%), Gaps = 49/673 (7%)
Query: 85 NSSIKKTLT-CPKNKILPQDELVQAQDVEI--RNKD--QTICEYNKQIEDYKNEIAQLQE 139
N IK+T+ P IL + V A+ +E+ R+ D + + E K +ED K + +++
Sbjct: 977 NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
Query: 140 ILKELATKFRQSHNNIDFNE-IDRKLSKLRINNTNCHTEHNAVQGT------DAEKVSAM 192
+ +EL + N + N+ +D+ L K + + + +++ D +
Sbjct: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR----DSLCKDLQ---EKLTSN 245
++ +I EL +K L E+ D++ S+E+ + D L K Q E L
Sbjct: 1097 LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ 1156
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
+L + + E + L+ + +REY+ EL ++ +EE + +K + +
Sbjct: 1157 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINI 1216
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
KT +I+ + Q + QL +L + +++K ++ ++ +S L+ E +
Sbjct: 1217 TKT----TIKEISMQKEDDSKNLRNQL-DRLSRENRDLKDEIVRLNDSI---LQATEQRR 1268
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
++Q+ E + EI ELK + + N+ KQ L + + E
Sbjct: 1269 RAEENALQQKACGSEIMQKKQHLEI-ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE- 1326
Query: 426 FNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
IE +K E ++ YENE +K+ N E+ I KN+FET +++T+ +H LT++
Sbjct: 1327 ---IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQ 1383
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL--VNILKSKA 542
E S Q+ LT L E+ KNTL T +E + S+
Sbjct: 1384 KEEDTSGYRA---QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440
Query: 543 ALTKEHTRIMEHNVTLIESLQNVE-KEAYRELG-TI--KNELIEDV-ELLKKESNSQIKF 597
+ K+ + VT + + ++V K++ + TI KN+ IE + +L+ KE+N +
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL 1500
Query: 598 LREEVEKKRVLCEM--XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXX 655
E +RV ++ L + D R+ E
Sbjct: 1501 EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560
Query: 656 SLVVELSLLRQENEE----LTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKE 711
+ + EL L +Q+ EE L T ++ S KL+++LE + + K ++ +L E
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 712 NMQTISPLRERNL 724
+ E +L
Sbjct: 1621 QASIVKKRSEDDL 1633
Score = 73.7 bits (173), Expect = 2e-12
Identities = 127/639 (19%), Positives = 266/639 (41%), Gaps = 55/639 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI-----DFN 158
E+ ++ + +N + +++ D K+EI +L + + + + R++ N +
Sbjct: 1223 EISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS 1282
Query: 159 EIDRKLSKLRINNTNC---HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
EI +K L I +E NA E+ + I D I L+ + + +
Sbjct: 1283 EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 1342
Query: 216 DKQMELSSL-----EEVITVRDSLCKDLQ-EKLTSNELTLAETQQRLEMVKGHHALALEA 269
+ + ELS + EE+I++++ ++ K T ++LT+ Q+ E G+ A
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTM----QKEEDTSGYRAQI--- 1395
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL 329
+++ RE + E +K + Q + +V+++ + K S S + Q L+ + +
Sbjct: 1396 -DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV 1454
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
Q+ ++ ++ K L+ ++ +K K EI ER + + + + K ++
Sbjct: 1455 TQMRTEESVR---YKQSLDDAAKTIQDKNK--EI---ERLKQLIDKETNDRKCLEDENAR 1506
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF--IEEIKTLKDELIEKTINYE 447
++ ++Y L NS + +N LK + EL+ + ++ + + +T+KD+ I + ++
Sbjct: 1507 LQRVQYDLQ---KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR---FQ 1560
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVT-------RDIVHVLTLRLRESDSELEQLEDQVQ 500
N +L L +K +E N+ + + S + + + L+E ++ L Q++
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK---EHTRIMEHNVT 557
+ K+ E++L ++ L+ +RE +E L + AL + + ++
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
E Q ++ R L K E IE ++ L + + L EE+ R+ E
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIE-IERLQSLTENLTKEHLMLEEELRNLRL--EYDDLRRG 1737
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
+ +L S+L+ N R L E LRQE E+ +
Sbjct: 1738 RSEADSDKNATILELR----SQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALE 1793
Query: 678 QSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
S+ I + K Q +S V K L+ K +Q +
Sbjct: 1794 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 1832
Score = 44.8 bits (101), Expect = 0.001
Identities = 66/317 (20%), Positives = 140/317 (44%), Gaps = 27/317 (8%)
Query: 102 QDELVQAQDV---EIRNKDQTICEYNK---QIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+D+L Q +DV +R K +T E + ++E + ++ Q QE +K+ + I
Sbjct: 1630 EDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI 1689
Query: 156 D-----FNEIDRKLSKLRINNTNCHTEHNAVQGT---------DAEKV-SAMINDMRSRI 200
+ NE ++ +L+ N EH ++ D + S +D + I
Sbjct: 1690 EDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI 1749
Query: 201 IELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+EL + + +N + Q ++ L+ E +R + K ++ L ++ Q ++V
Sbjct: 1750 LELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVV 1809
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ--ENLKTKHNASIESL 317
+ +L ++ + + K L+ L+ +L+ K + ++ +V Q E K + +
Sbjct: 1810 QERESLLVKIK--VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 1867
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K Q +++ EA+ ++ S+ E+E + +IE +E +I E + S +E S
Sbjct: 1868 KTQYSRKE-EAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
Query: 378 QQEKTIQYLEQEIKELK 394
Q E ++EI +L+
Sbjct: 1927 QLETERSRYQREIDKLR 1943
>AB053469-1|BAC54108.1| 720|Homo sapiens ELKS gamma protein.
Length = 720
Score = 95.5 bits (227), Expect = 6e-19
Identities = 118/539 (21%), Positives = 254/539 (47%), Gaps = 40/539 (7%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATK---FRQSHNN 154
++L +++L++ +DVE++ + + N + E+ + + + K+ A+K +++ +
Sbjct: 160 EVLRENDLLR-KDVEVK-ESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRV 217
Query: 155 I-DFNEIDRKLSKLRINNTNCHTEHNAVQ------GTDAEKVSAMIN--DMRSRIIE-LE 204
+ + N++D +L T + + +Q GT A ++ + + D++ R + L+
Sbjct: 218 VQEENQVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 277
Query: 205 KKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA 264
KK E L ++ DK+ ++SSL+E + + + LT+ E LAE ++ +E +K
Sbjct: 278 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 337
Query: 265 LALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES---LKNQM 321
+ YK +L+ LK K+ Q +S+ + +LK +H +S+ S K+
Sbjct: 338 RDEREKQEEIDNYKKDLKDLKEKV-SLLQGDLSEKEASLLDLK-EHASSLASSGLKKDSR 395
Query: 322 LKEKCEALEQLHSQLIIKEQEMK----AKLE-QIEESASEKLKICE---IQFEERSQSIQ 373
LK ALEQ + + E ++K A LE + S++++ E ++++ S Q
Sbjct: 396 LKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 455
Query: 374 EHCSQQEKTIQYLEQE----IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
+ + ++ +E E K++ LT+ Q D +++ NLK+ + + +
Sbjct: 456 AEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQML 515
Query: 430 EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD 489
EE + +D L + + ++ K + +E+ ++E + ++ R++V L + +
Sbjct: 516 EEARRREDNLNDSSQQLQDSLRKKDDRIEE-LEEALRESVQITAEREMV------LAQEE 568
Query: 490 SELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHT 549
S E QV+ L A E ++ EL + K L++T + E + L N L+++ E
Sbjct: 569 SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEV 627
Query: 550 RIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
M+ L + A EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 628 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 686
Score = 56.0 bits (129), Expect = 4e-07
Identities = 68/349 (19%), Positives = 149/349 (42%), Gaps = 28/349 (8%)
Query: 264 ALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVDQENLKTKHNASIESLKNQ 320
++A S+R+ + L+T+L E E + +V + L + N+ +
Sbjct: 134 SMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE 193
Query: 321 MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ- 379
+ KE+ ++ I KEQ + E ++ +L+ E ++++ IQ+ ++
Sbjct: 194 LKKERALRKDEASKITIWKEQYRVVQEENQVDALRLRLEEKETMLNKKTKQIQDMAEEKG 253
Query: 380 ---------EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
+ + E+++ L+ ++ Q D ++++++LK L + N
Sbjct: 254 TQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 313
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
+ TL++ L EK E K + + + +E + ++ L ++ V +L L E ++
Sbjct: 314 ALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEA 373
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
L L++ L S+ ++ L T + L EC LK ++ L K H
Sbjct: 374 SLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC----------LKMESQLKKAHEA 423
Query: 551 IMEHNVT--LIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQ 594
+E + + + +Q++E+E R E + E+ +E+LK+ N +
Sbjct: 424 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 472
>AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein.
Length = 1583
Score = 91.5 bits (217), Expect = 1e-17
Identities = 122/505 (24%), Positives = 231/505 (45%), Gaps = 46/505 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK-LSKLRINNTNCHTEHNAVQGTDA 186
++ K + QLQ I++ + ++++ N++ + K + + + C E A
Sbjct: 109 DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIE------ASA 162
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDK-QMELSSLEEVITVRDS---LCKDLQEKL 242
++ A IN + L K+CEA + + K + EL +L + + + +C L ++
Sbjct: 163 KEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQEN 222
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
T E + E + LE LE+ SI ++ + LK KL+ + Q I + +
Sbjct: 223 TFVEQVVNEKVKHLEDTLKE----LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHE 278
Query: 303 QENLKTKHN----------ASIESLKNQML---KEKCEALEQLHSQL-IIKEQEMK--AK 346
+E+L+ K N IE LK+++ K+ C +EQ + ++ +KEQ K ++
Sbjct: 279 REDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISE 338
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCS--QQEKTIQYLEQE-IKELKYTLDLTNNQ 403
L + S SEK K+ + FE Q ++E C QQEK L E ++E+ L +
Sbjct: 339 LNETFLSDSEKEKLT-LMFE--IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGE 395
Query: 404 NSD-LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
++ + QE ++K + E + T KD L+E + E KL L+ ++ +
Sbjct: 396 SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKL-LSQQELVP 454
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
E E ++ ++ V L L + D+ L++LE ++ LT K+ N+L ++N
Sbjct: 455 E---LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDN 511
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEKEAYRELGTIKNELI 581
++C E +E L+ L K T ++ +E V L L+ KE + ++ ++
Sbjct: 512 FHKKC-EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 570
Query: 582 EDVELL--KKESNSQIKFLREEVEK 604
+ L K+ ++++K L EE K
Sbjct: 571 QMKVLSEDKEVLSAEVKSLYEENNK 595
Score = 87.0 bits (206), Expect = 2e-16
Identities = 108/533 (20%), Positives = 243/533 (45%), Gaps = 40/533 (7%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S K+ L+ + ++ + ++ ++ ++D + K+ K I QL++ L+ +
Sbjct: 576 SEDKEVLSAEVKSLYEENNKLSSEKKQL-SRDLEVFLSQKEDVILKEHITQLEKKLQLMV 634
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-E 204
+ + ++ ++ + K ++ + ++ + V ++ + + ++ E
Sbjct: 635 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINE 694
Query: 205 KKCEAL---DNEVYDKQMELSSLEEVITVR----DSLCKDLQEKLTSNELTLAETQQRLE 257
+KC D +V + + E+ L+E V+ SL +D +++ L E Q E
Sbjct: 695 EKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKE 754
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
++ ANE R +E + L +++E Q SK ++ E K E+L
Sbjct: 755 ALQSDLLEMKNANEKTR----LENQNLLIQVEEVSQTC-SKSEIHNEKEKCFIKEH-ENL 808
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K +L++K L ++LI+ + + AK ++ +K + EE+ +++++ C
Sbjct: 809 K-PLLEQK--ELRDRRAELILLKDSL-AKSPSVKNDPLSSVK----ELEEKIENLEKECK 860
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
++E+ I ++ + K LD + + +K+EL +L++ KD+LS + I+ ++ K+
Sbjct: 861 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 920
Query: 438 ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
L+E YE + +L++ E+A +++ E +TR + + TL+ +S+ E L
Sbjct: 921 LLLE----YEKQSEQLDVEKERANNFEHRIE---DLTRQLRN-STLQCETINSDNEDLLA 972
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE----HTRIME 553
+++ L S ++LE ++ + +E + K +K A E ++ +
Sbjct: 973 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQK 1032
Query: 554 HNVTLIESLQNVE---KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
L +++Q +E K+A + T+ N I D E L KE N ++ ++E
Sbjct: 1033 QKKQLQKTMQELELVKKDAQQT--TLMNMEIADYERLMKELNQKLTNKNNKIE 1083
Score = 79.8 bits (188), Expect = 3e-14
Identities = 115/507 (22%), Positives = 217/507 (42%), Gaps = 42/507 (8%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q+EL+Q + + + +C+ ++++ EI +L E+ + L + S NI + +
Sbjct: 137 QEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ-KKYE 195
Query: 162 RKLSKLRINNTNCHTEHNAV-----QGTDAEK-VSAMINDMRSRIIELEKKCEALDNEV- 214
+L LR +N + ++ + T E+ V+ + + + ELE + L +EV
Sbjct: 196 CELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 255
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQE-KLTSNELTLAETQQR--LEMVKGHHALALEANE 271
Y ++L + ++D + ++ + NEL LA+ +Q +E +K A +
Sbjct: 256 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFC 315
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ---MLKEKCEA 328
++ E+++LK + +E + D E K I+ LK Q + +EK EA
Sbjct: 316 YTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEA 375
Query: 329 L---EQLHSQLIIKEQEM---KAKLEQIEESASEK--LKICEIQ------FEE------- 367
+ E L + I + E+ K+ Q ES ++ + E+Q F E
Sbjct: 376 ILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLET 435
Query: 368 --RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
R Q E Q++ + LE IK L+ + S L L+ + L+ EK
Sbjct: 436 VNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEK 495
Query: 426 FNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
+FI ++K +E+ E E+ +L VE+ I+ ++ E ++ +
Sbjct: 496 DDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETL 555
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
++D +LE+L Q+++L+ KEVL E+ + N E + L L K
Sbjct: 556 KEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKE 615
Query: 543 -ALTKEHTRIMEHNVTL-IESLQNVEK 567
+ KEH +E + L +E N+ K
Sbjct: 616 DVILKEHITQLEKKLQLMVEEQDNLNK 642
Score = 73.3 bits (172), Expect = 3e-12
Identities = 100/487 (20%), Positives = 213/487 (43%), Gaps = 38/487 (7%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA- 186
E YKN + + ++ ++L + ++ NN + + I+ +LR + C T ++ + A
Sbjct: 916 ESYKNLLLEYEKQSEQLDVE-KERANNFE-HRIEDLTRQLRNSTLQCETINSDNEDLLAR 973
Query: 187 -EKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITVRDSLCKDLQEKLTS 244
E + + + +I+E+++ +D E+ +K + ++E T + L ++LQ +L
Sbjct: 974 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL-EELQVQLQK 1032
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIIS---KCKV 301
+ L +T Q LE+VK N I +Y+ ++ L KL + I + K+
Sbjct: 1033 QKKQLQKTMQELELVKKDAQQTTLMNMEIA-DYERLMKELNQKLTNKNNKIEDLEQEIKI 1091
Query: 302 DQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE-------SA 354
++ +T I SL++ + ++ E QL++K ++ A +Q E S
Sbjct: 1092 QKQKQETLQE-EITSLQSSV--QQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1148
Query: 355 SEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+L+ + Q E + E S++ K ++L+ ++ + TL + + L++E
Sbjct: 1149 KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1208
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
K E+ E ++ K + + + K+ E A +E+ E
Sbjct: 1209 K-------AEQATVTSEFESYKVR-VHNVLKQQKNKSMSQAETEGAKQEREHLEM----- 1255
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
++ L ++L++S + L+ ++Q L S + L L + L TV + E +E L
Sbjct: 1256 --LIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL---LERHNKMLQETVSKEAELREKL 1310
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ 594
+I + EHT+ + + E L+N ++ R L + +E ++ + +Q
Sbjct: 1311 CSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQ 1370
Query: 595 IKFLREE 601
+ L+ E
Sbjct: 1371 LFQLKNE 1377
Score = 62.5 bits (145), Expect = 5e-09
Identities = 108/488 (22%), Positives = 208/488 (42%), Gaps = 52/488 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEI-----------AQLQEILKELATKFRQ 150
+D + + D + +Q+ Y K+IE+ KNE+ A LQ+ L+E +
Sbjct: 6 EDSVTKMGDAH-KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLE 64
Query: 151 SHNNIDF-NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEA 209
+ F N + + KL+ +++ A ++ + + +L+ EA
Sbjct: 65 LSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEA 124
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ---QRLEMVKGHHALA 266
+++ Y K + S EE++ ++ ++++E + E + E + +L +K +
Sbjct: 125 -NSQHYQKNIN-SLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQ 182
Query: 267 LEANE-SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
EA+E +I+++Y+ ELE L+ Q C ++ + N +E + N+ +K
Sbjct: 183 CEASEKNIQKKYECELENLRKATSNANQD-NQIC-----SILLQENTFVEQVVNEKVKHL 236
Query: 326 CEALEQLHSQ-LIIKEQ-----EMKAKLE----QIEESASEKLKICEIQFEERSQSIQEH 375
+ L++L SQ I+K++ +K KLE I++ + + E + E + +E
Sbjct: 237 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 296
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ-------ELNN--LKNCKDELSTEKF 426
EK L K+ YT++ N + LK+ ELN L + + E T F
Sbjct: 297 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 356
Query: 427 ---NFIEEIKTLKDELIEKTINYENEKNKLNLAV----EKAIKEKNKFETSLSVTRDIVH 479
E+ + L+ E E +NYE+ + + + E A K +FE+ VH
Sbjct: 357 EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 416
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
L +LR + +E + L + V L E L ++ L NT++ E + L
Sbjct: 417 ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE-LENTIKNLQEKNGVYLLSLS 475
Query: 540 SKAALTKE 547
+ + KE
Sbjct: 476 QRDTMLKE 483
Score = 55.2 bits (127), Expect = 8e-07
Identities = 104/555 (18%), Positives = 220/555 (39%), Gaps = 55/555 (9%)
Query: 3 SKAKRFEPLVAQKNQKKTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXX 62
S AK E + + + K V K+L++E + K K + T+N + +
Sbjct: 979 SNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKI-----KEHATTVNELEELQ------ 1027
Query: 63 XXXXXXXLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICE 122
K K + + ++T T +I + L++ + ++ NK+ I +
Sbjct: 1028 --VQLQKQKKQLQKTMQELELVKKDAQQT-TLMNMEIADYERLMKELNQKLTNKNNKIED 1084
Query: 123 YNKQIEDYKNEIAQLQEILKELATKFRQ-SHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
++I+ K + LQE + L + +Q N ++ K K ++ T+H +
Sbjct: 1085 LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLIL 1144
Query: 182 QGT---DAEKVSAMINDMRSRIIEL----EKKCEALDNEVYDKQMELSSLEEVITVRDSL 234
Q + + E + + ++ E+ K E L Q LS+ ++ +T
Sbjct: 1145 QASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE 1204
Query: 235 CKDLQEKLTSNELTLAETQQRLEMV------KGHHALALEANESIRREYKIELEALKTKL 288
C+ + + + + R+ V K E + R ++ ++ LK KL
Sbjct: 1205 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1264
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQE---MKA 345
+ + + + + L+++H+ +E N+ML+E +L +L + E MK+
Sbjct: 1265 QDSQNNLQINVS-ELQTLQSEHDTLLER-HNKMLQETVSKEAELREKLCSIQSENMMMKS 1322
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
+ Q + + ++ F ++ + +QE + KT++ L+Q++ +++ L N+ +
Sbjct: 1323 EHTQTVSQLTSQNEVLRNSFRDQVRHLQE---EHRKTVETLQQQLSKMEAQLFQLKNEPT 1379
Query: 406 -----DLKQELNNLKNCKD------ELSTEKFNFIEEIKTLKDELIEKTINY-------- 446
+Q L NL+ ++ ++ T E ++T E + Y
Sbjct: 1380 TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL 1439
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
+ + KL + A K + LS T L LRE+++ L +Q+++L S
Sbjct: 1440 NSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI 1499
Query: 507 EVLENELTTYKNTLN 521
LE K+ N
Sbjct: 1500 RRLERNQEREKSAAN 1514
Score = 52.0 bits (119), Expect = 7e-06
Identities = 95/508 (18%), Positives = 205/508 (40%), Gaps = 36/508 (7%)
Query: 8 FEPLVAQKNQKKTNVHKKLDS--ESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXX 65
+E L+ + NQK TN + K++ + KI + +L + ++ +S++ +
Sbjct: 1064 YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQL 1123
Query: 66 XXXXLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNK 125
K K + + ++ +L Q E+ + Q EI ++ I E+ K
Sbjct: 1124 LVKTKKELADS--KQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK 1181
Query: 126 -QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
E ++ ++ Q+ + L + R + + + K+R++N ++ ++
Sbjct: 1182 TSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQA 1241
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+ E + I +L+ K + N + Q+ +S L+ + + D+L + + L
Sbjct: 1242 ETEGAKQEREHLEMLIDQLKIKLQDSQNNL---QINVSELQTLQSEHDTLLERHNKMLQE 1298
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE 304
AE +++L ++ + + K E ++L + + + + +
Sbjct: 1299 TVSKEAELREKLCSIQSENMMM-----------KSEHTQTVSQLTSQNEVLRNSFRDQVR 1347
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
+L+ +H ++E+L+ Q+ K + + + + + L+ + E + L + ++
Sbjct: 1348 HLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMH 1407
Query: 365 FEERSQ------SIQEHCSQQEKTIQYLEQEIK--ELKYTLDLTNNQ--NSDLKQELNNL 414
R + + E S Q LEQ + E K L + + +L Q+L++
Sbjct: 1408 TVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSST 1467
Query: 415 KNCKDELS-----TEKFNFI--EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKF 467
D L+ TE N I E+IK LK E+ N E EK+ NL K + + F
Sbjct: 1468 TKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIF 1527
Query: 468 ETSLSVTRDIVHVLTLRLRESDSELEQL 495
S ++ V+ L+ S E +L
Sbjct: 1528 LKPGSERERLLPVINTMLQLSPEEKGKL 1555
Score = 51.2 bits (117), Expect = 1e-05
Identities = 108/546 (19%), Positives = 230/546 (42%), Gaps = 40/546 (7%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV-RDSLCKDLQEKLTSN 245
++V + M ELE+ E+ + + EL ++ + + +L K L+E + +
Sbjct: 3 QEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNT- 61
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD---EEKQAIISKCKVD 302
+L L+E + + + E E IR ++ ++ L+ +LD +EK+ +++ +
Sbjct: 62 QLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI 121
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
E + +I SL+ ++L+ K I ++E+K + QIE SA E E
Sbjct: 122 IEANSQHYQKNINSLQEELLQLKA-----------IHQEEVKELMCQIEASAKEHE--AE 168
Query: 363 I-QFEERSQSIQEHCSQQEKTIQY-LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
I + E +++ + C EK IQ E E++ L+ NQ++ + L ++
Sbjct: 169 INKLNELKENLVKQCEASEKNIQKKYECELENLRKATS-NANQDNQICSILLQENTFVEQ 227
Query: 421 LSTEKFNFIEE-IKTLKDE--LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
+ EK +E+ +K L+ + +++ + Y N KL L ++ A K++F
Sbjct: 228 VVNEKVKHLEDTLKELESQHSILKDEVTYMNNL-KLKLEMD-AQHIKDEFFHEREDLEFK 285
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAK-EVLENELTTYKNTLNNTVRECDEYKEALVN 536
++ L L E +E+L+ ++ L +E ++ +E E E ++
Sbjct: 286 INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLS 345
Query: 537 ILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
+ KE +M L E +N+++E + ++ L E +E+L+ E
Sbjct: 346 DSE------KEKLTLMFEIQGLKEQCENLQQEKQEAILNYES-LREIMEILQTELGESAG 398
Query: 597 FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXS 656
+ +E E + + L + ++RL+ ENE+
Sbjct: 399 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLET---VNRLQGENEKLLSQQELVPE 455
Query: 657 LVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
L + L+++N ++++++ +++ +L+ + + T + + K LK E M
Sbjct: 456 LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI--NSLTEEKDDFINK-LKNSHEEMDNF 512
Query: 717 SPLRER 722
ER
Sbjct: 513 HKKCER 518
>AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein.
Length = 1635
Score = 91.5 bits (217), Expect = 1e-17
Identities = 122/505 (24%), Positives = 231/505 (45%), Gaps = 46/505 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK-LSKLRINNTNCHTEHNAVQGTDA 186
++ K + QLQ I++ + ++++ N++ + K + + + C E A
Sbjct: 161 DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIE------ASA 214
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDK-QMELSSLEEVITVRDS---LCKDLQEKL 242
++ A IN + L K+CEA + + K + EL +L + + + +C L ++
Sbjct: 215 KEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQEN 274
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
T E + E + LE LE+ SI ++ + LK KL+ + Q I + +
Sbjct: 275 TFVEQVVNEKVKHLEDTLKE----LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHE 330
Query: 303 QENLKTKHN----------ASIESLKNQML---KEKCEALEQLHSQL-IIKEQEMK--AK 346
+E+L+ K N IE LK+++ K+ C +EQ + ++ +KEQ K ++
Sbjct: 331 REDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISE 390
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCS--QQEKTIQYLEQE-IKELKYTLDLTNNQ 403
L + S SEK K+ + FE Q ++E C QQEK L E ++E+ L +
Sbjct: 391 LNETFLSDSEKEKLT-LMFE--IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGE 447
Query: 404 NSD-LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
++ + QE ++K + E + T KD L+E + E KL L+ ++ +
Sbjct: 448 SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKL-LSQQELVP 506
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
E E ++ ++ V L L + D+ L++LE ++ LT K+ N+L ++N
Sbjct: 507 E---LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDN 563
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEKEAYRELGTIKNELI 581
++C E +E L+ L K T ++ +E V L L+ KE + ++ ++
Sbjct: 564 FHKKC-EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 622
Query: 582 EDVELL--KKESNSQIKFLREEVEK 604
+ L K+ ++++K L EE K
Sbjct: 623 QMKVLSEDKEVLSAEVKSLYEENNK 647
Score = 87.0 bits (206), Expect = 2e-16
Identities = 108/533 (20%), Positives = 243/533 (45%), Gaps = 40/533 (7%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S K+ L+ + ++ + ++ ++ ++D + K+ K I QL++ L+ +
Sbjct: 628 SEDKEVLSAEVKSLYEENNKLSSEKKQL-SRDLEVFLSQKEDVILKEHITQLEKKLQLMV 686
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-E 204
+ + ++ ++ + K ++ + ++ + V ++ + + ++ E
Sbjct: 687 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINE 746
Query: 205 KKCEAL---DNEVYDKQMELSSLEEVITVR----DSLCKDLQEKLTSNELTLAETQQRLE 257
+KC D +V + + E+ L+E V+ SL +D +++ L E Q E
Sbjct: 747 EKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKE 806
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
++ ANE R +E + L +++E Q SK ++ E K E+L
Sbjct: 807 ALQSDLLEMKNANEKTR----LENQNLLIQVEEVSQTC-SKSEIHNEKEKCFIKEH-ENL 860
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K +L++K L ++LI+ + + AK ++ +K + EE+ +++++ C
Sbjct: 861 K-PLLEQK--ELRDRRAELILLKDSL-AKSPSVKNDPLSSVK----ELEEKIENLEKECK 912
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
++E+ I ++ + K LD + + +K+EL +L++ KD+LS + I+ ++ K+
Sbjct: 913 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 972
Query: 438 ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
L+E YE + +L++ E+A +++ E +TR + + TL+ +S+ E L
Sbjct: 973 LLLE----YEKQSEQLDVEKERANNFEHRIE---DLTRQLRN-STLQCETINSDNEDLLA 1024
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE----HTRIME 553
+++ L S ++LE ++ + +E + K +K A E ++ +
Sbjct: 1025 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQK 1084
Query: 554 HNVTLIESLQNVE---KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
L +++Q +E K+A + T+ N I D E L KE N ++ ++E
Sbjct: 1085 EKKQLQKTMQELELVKKDAQQT--TLMNMEIADYERLMKELNQKLTNKNNKIE 1135
Score = 79.8 bits (188), Expect = 3e-14
Identities = 115/507 (22%), Positives = 217/507 (42%), Gaps = 42/507 (8%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q+EL+Q + + + +C+ ++++ EI +L E+ + L + S NI + +
Sbjct: 189 QEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ-KKYE 247
Query: 162 RKLSKLRINNTNCHTEHNAV-----QGTDAEK-VSAMINDMRSRIIELEKKCEALDNEV- 214
+L LR +N + ++ + T E+ V+ + + + ELE + L +EV
Sbjct: 248 CELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 307
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQE-KLTSNELTLAETQQR--LEMVKGHHALALEANE 271
Y ++L + ++D + ++ + NEL LA+ +Q +E +K A +
Sbjct: 308 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFC 367
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ---MLKEKCEA 328
++ E+++LK + +E + D E K I+ LK Q + +EK EA
Sbjct: 368 YTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEA 427
Query: 329 L---EQLHSQLIIKEQEM---KAKLEQIEESASEK--LKICEIQ------FEE------- 367
+ E L + I + E+ K+ Q ES ++ + E+Q F E
Sbjct: 428 ILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLET 487
Query: 368 --RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
R Q E Q++ + LE IK L+ + S L L+ + L+ EK
Sbjct: 488 VNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEK 547
Query: 426 FNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
+FI ++K +E+ E E+ +L VE+ I+ ++ E ++ +
Sbjct: 548 DDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETL 607
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
++D +LE+L Q+++L+ KEVL E+ + N E + L L K
Sbjct: 608 KEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKE 667
Query: 543 -ALTKEHTRIMEHNVTL-IESLQNVEK 567
+ KEH +E + L +E N+ K
Sbjct: 668 DVILKEHITQLEKKLQLMVEEQDNLNK 694
Score = 73.3 bits (172), Expect = 3e-12
Identities = 100/487 (20%), Positives = 213/487 (43%), Gaps = 38/487 (7%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA- 186
E YKN + + ++ ++L + ++ NN + + I+ +LR + C T ++ + A
Sbjct: 968 ESYKNLLLEYEKQSEQLDVE-KERANNFE-HRIEDLTRQLRNSTLQCETINSDNEDLLAR 1025
Query: 187 -EKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITVRDSLCKDLQEKLTS 244
E + + + +I+E+++ +D E+ +K + ++E T + L ++LQ +L
Sbjct: 1026 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL-EELQVQLQK 1084
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIIS---KCKV 301
+ L +T Q LE+VK N I +Y+ ++ L KL + I + K+
Sbjct: 1085 EKKQLQKTMQELELVKKDAQQTTLMNMEIA-DYERLMKELNQKLTNKNNKIEDLEQEIKI 1143
Query: 302 DQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE-------SA 354
++ +T I SL++ + ++ E QL++K ++ A +Q E S
Sbjct: 1144 QKQKQETLQE-EITSLQSSV--QQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1200
Query: 355 SEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+L+ + Q E + E S++ K ++L+ ++ + TL + + L++E
Sbjct: 1201 KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1260
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
K E+ E ++ K + + + K+ E A +E+ E
Sbjct: 1261 K-------AEQATVTSEFESYKVR-VHNVLKQQKNKSMSQAETEGAKQEREHLEM----- 1307
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
++ L ++L++S + L+ ++Q L S + L L + L TV + E +E L
Sbjct: 1308 --LIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL---LERHNKMLQETVSKEAELREKL 1362
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ 594
+I + EHT+ + + E L+N ++ R L + +E ++ + +Q
Sbjct: 1363 CSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQ 1422
Query: 595 IKFLREE 601
+ L+ E
Sbjct: 1423 LFQLKNE 1429
Score = 63.3 bits (147), Expect = 3e-09
Identities = 112/503 (22%), Positives = 215/503 (42%), Gaps = 54/503 (10%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEI-----------A 135
S+KK K ++ +D + + D + +Q+ Y K+IE+ KNE+ A
Sbjct: 45 SLKKENIKMKQEV--EDSVTKMGDAH-KELEQSHINYVKEIENLKNELMAVRSKYSEDKA 101
Query: 136 QLQEILKELATKFRQSHNNIDF-NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIN 194
LQ+ L+E + + F N + + KL+ +++ A +
Sbjct: 102 NLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTD 161
Query: 195 DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ- 253
+ + + +L+ EA +++ Y K + S EE++ ++ ++++E + E + E +
Sbjct: 162 EKKETVTQLQNIIEA-NSQHYQKNIN-SLQEELLQLKAIHQEEVKELMCQIEASAKEHEA 219
Query: 254 --QRLEMVKGHHALALEANE-SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
+L +K + EA+E +I+++Y+ ELE L+ Q C ++ +
Sbjct: 220 EINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD-NQIC-----SILLQE 273
Query: 311 NASIESLKNQMLKEKCEALEQLHSQ-LIIKEQ-----EMKAKLE----QIEESASEKLKI 360
N +E + N+ +K + L++L SQ I+K++ +K KLE I++ + +
Sbjct: 274 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERED 333
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ-------ELNN 413
E + E + +E EK L K+ YT++ N + LK+ ELN
Sbjct: 334 LEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNE 393
Query: 414 --LKNCKDELSTEKF---NFIEEIKTLKDELIEKTINYENEKNKLNLAV----EKAIKEK 464
L + + E T F E+ + L+ E E +NYE+ + + + E A K
Sbjct: 394 TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS 453
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
+FE+ VH L +LR + +E + L + V L E L ++ L NT+
Sbjct: 454 QEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE-LENTI 512
Query: 525 RECDEYKEALVNILKSKAALTKE 547
+ E + L + + KE
Sbjct: 513 KNLQEKNGVYLLSLSQRDTMLKE 535
Score = 54.8 bits (126), Expect = 1e-06
Identities = 87/460 (18%), Positives = 188/460 (40%), Gaps = 41/460 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ-SHNNID 156
+I + L++ + ++ NK+ I + ++I+ K + LQE + L + +Q N
Sbjct: 1112 EIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTK 1171
Query: 157 FNEIDRKLSKLRINNTNCHTEHNAVQGT---DAEKVSAMINDMRSRIIEL----EKKCEA 209
++ K K ++ T+H +Q + + E + + ++ E+ K E
Sbjct: 1172 IKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEH 1231
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV------KGHH 263
L Q LS+ ++ +T C+ + + + + R+ V K
Sbjct: 1232 LKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMS 1291
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
E + R ++ ++ LK KL + + + + + L+++H+ +E N+ML+
Sbjct: 1292 QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVS-ELQTLQSEHDTLLER-HNKMLQ 1349
Query: 324 EKCEALEQLHSQLIIKEQE---MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQE 380
E +L +L + E MK++ Q + + ++ F ++ + +QE +
Sbjct: 1350 ETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQE---EHR 1406
Query: 381 KTIQYLEQEIKELKYTLDLTNNQNS-----DLKQELNNLKNCKD------ELSTEKFNFI 429
KT++ L+Q++ +++ L N+ + +Q L NL+ ++ ++ T
Sbjct: 1407 KTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEG 1466
Query: 430 EEIKTLKDELIEKTINY--------ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
E ++T E + Y + + KL + A K + LS T L
Sbjct: 1467 EGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL 1526
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
LRE+++ L +Q+++L S LE K+ N
Sbjct: 1527 NGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAAN 1566
Score = 52.0 bits (119), Expect = 7e-06
Identities = 112/606 (18%), Positives = 266/606 (43%), Gaps = 78/606 (12%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID--RKLSKLRINNTNCHTEHN 179
E +Q K E ++++ +++ TK +H ++ + I+ +++ L+ ++++
Sbjct: 38 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 97
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
D + + + + +EL ++ + +N + + +E++ + LQ
Sbjct: 98 E----DKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQ 153
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
++L + ET +L+ + ++ + N + +E ++L+A+ EE + ++ +
Sbjct: 154 KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH---QEEVKELMCQI 210
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK-LEQIEESASEKL 358
+ + + + N + LK ++K+ CEA E+ I K+ E + + L + +A++
Sbjct: 211 EASAKEHEAEIN-KLNELKENLVKQ-CEASEKN----IQKKYECELENLRKATSNANQDN 264
Query: 359 KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
+IC I +E + +++ +++ +++LE +KEL+ +Q+S LK E+ + N K
Sbjct: 265 QICSILLQENT-FVEQVVNEK---VKHLEDTLKELE-------SQHSILKDEVTYMNNLK 313
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK--AIKEKNKFETSLSVTRD 476
+L + + +KDE + + E + N+L LA E+ + EK K E + + +
Sbjct: 314 LKLEMDA-------QHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELA-GLNKQ 365
Query: 477 IVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVN 536
+ + RE S EQ + ++ L E ++ K TL + E KE N
Sbjct: 366 FCYTVEQHNREVQSLKEQHQKEISELN---ETFLSDSEKEKLTL---MFEIQGLKEQCEN 419
Query: 537 ILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
+ + K + + ESL+ + + ELG ++ ++ E +K++ S +
Sbjct: 420 LQQEK-----------QEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 468
Query: 597 FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXS 656
L++++ + L + ++RL+ ENE+
Sbjct: 469 ELQQKLR------------------TAFTEKDALLET---VNRLQGENEKLLSQQELVPE 507
Query: 657 LVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
L + L+++N ++++++ +++ +L+ + + T + + K LK E M
Sbjct: 508 LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI--NSLTEEKDDFINK-LKNSHEEMDNF 564
Query: 717 SPLRER 722
ER
Sbjct: 565 HKKCER 570
Score = 52.0 bits (119), Expect = 7e-06
Identities = 95/508 (18%), Positives = 205/508 (40%), Gaps = 36/508 (7%)
Query: 8 FEPLVAQKNQKKTNVHKKLDS--ESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXX 65
+E L+ + NQK TN + K++ + KI + +L + ++ +S++ +
Sbjct: 1116 YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQL 1175
Query: 66 XXXXLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNK 125
K K + + ++ +L Q E+ + Q EI ++ I E+ K
Sbjct: 1176 LVKTKKELADS--KQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK 1233
Query: 126 -QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
E ++ ++ Q+ + L + R + + + K+R++N ++ ++
Sbjct: 1234 TSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQA 1293
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+ E + I +L+ K + N + Q+ +S L+ + + D+L + + L
Sbjct: 1294 ETEGAKQEREHLEMLIDQLKIKLQDSQNNL---QINVSELQTLQSEHDTLLERHNKMLQE 1350
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE 304
AE +++L ++ + + K E ++L + + + + +
Sbjct: 1351 TVSKEAELREKLCSIQSENMMM-----------KSEHTQTVSQLTSQNEVLRNSFRDQVR 1399
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
+L+ +H ++E+L+ Q+ K + + + + + L+ + E + L + ++
Sbjct: 1400 HLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMH 1459
Query: 365 FEERSQ------SIQEHCSQQEKTIQYLEQEIK--ELKYTLDLTNNQ--NSDLKQELNNL 414
R + + E S Q LEQ + E K L + + +L Q+L++
Sbjct: 1460 TVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSST 1519
Query: 415 KNCKDELS-----TEKFNFI--EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKF 467
D L+ TE N I E+IK LK E+ N E EK+ NL K + + F
Sbjct: 1520 TKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIF 1579
Query: 468 ETSLSVTRDIVHVLTLRLRESDSELEQL 495
S ++ V+ L+ S E +L
Sbjct: 1580 LKPGSERERLLPVINTMLQLSPEEKGKL 1607
>D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heavy
chain protein.
Length = 1052
Score = 91.1 bits (216), Expect = 1e-17
Identities = 138/649 (21%), Positives = 280/649 (43%), Gaps = 51/649 (7%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATK 147
++K K K L + LV +K++ + E ++I D +A+ +E K L TK
Sbjct: 85 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE--ERISDLTTNLAEEEEKAKNL-TK 141
Query: 148 FRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ H ++ +E++ +L K + ++G DA I D++++I EL+ +
Sbjct: 142 LKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEG-DASDFHEQIADLQAQIAELKMQL 199
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ E+ Q L+ L++ I +++ K ++E E +++ Q+ L+ + A
Sbjct: 200 AKKEEEL---QAALARLDDEIAQKNNALKKIREL----EGHISDLQEDLDSERA----AR 248
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
E +R+ ELEALKT+L++ + + Q+ L+ K + LK + +E
Sbjct: 249 NKAEKQKRDLGEELEALKTELEDTLDSTAT-----QQELRAKREQEVTVLKKALDEET-- 301
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
+ H + QEM+ K Q E +E+L+ QF+ ++ ++ EK L
Sbjct: 302 ---RSHEAQV---QEMRQKHAQAVEELTEQLE----QFKRAKANLDKNKQTLEKENADLA 351
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKN-CKD-ELSTEKFNFIEEIKTLKDELIEKT-I 444
E++ L ++ L+ ++ L++ C D E + + N +++ L++E+ T +
Sbjct: 352 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN--DKVHKLQNEVESVTGM 409
Query: 445 NYENEKNKLNLAVEKAIKEKNKFETSLSV---TRDIVHVLTLRLRESDSELEQLEDQVQM 501
E E + LA + A +T + TR ++V T +LR+ + E L+DQ+
Sbjct: 410 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST-KLRQLEEERNSLQDQLDE 468
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE---HTRIMEHNVTL 558
AK+ LE ++T L+++ ++ ++ + + + K KE T+ E
Sbjct: 469 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 528
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX--XXXX 616
+ L+ + +EL + +L +L+ Q KF + E+K + +
Sbjct: 529 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 588
Query: 617 XXXXXXXXXSRVLLAQAAADLSRLENENER-YXXXXXXXXSLVVELSLLRQENEELTMTV 675
+ LA+A + + E ER LV + + EL +
Sbjct: 589 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 648
Query: 676 AKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
+ ++++K LE+ + ++ + L+V NMQ + ER+L
Sbjct: 649 RALETQMEEMKTQLEELEDELQASEDAKLRLEV---NMQALKGQFERDL 694
Score = 76.2 bits (179), Expect = 4e-13
Identities = 86/430 (20%), Positives = 186/430 (43%), Gaps = 21/430 (4%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 288 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 347
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 348 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 406
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 407 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 462
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 463 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 516
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 517 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 576
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 577 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 632
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 633 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFER 692
Query: 523 TVRECDEYKE 532
++ DE E
Sbjct: 693 DLQARDEQNE 702
Score = 74.1 bits (174), Expect = 2e-12
Identities = 111/521 (21%), Positives = 235/521 (45%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 523 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 581
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 582 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 641
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L ++E + ++ +KG L+A N
Sbjct: 642 HELEKSKRALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQN 701
Query: 271 ESIRREYKIELEALKTKLDEEK--QAIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E+ +A+ + K E +LK +E + +K + E
Sbjct: 702 EEKRRQLQRQLHEYETELEDERNERALAAAAKKKLEGDLK-----DLELQADSAIKGREE 756
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 757 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 814
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 815 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 867
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 868 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 927
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 928 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 983
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 984 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1023
Score = 61.3 bits (142), Expect = 1e-08
Identities = 113/610 (18%), Positives = 241/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 422 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 479
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 480 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 536
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 537 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 596
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 597 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 652
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 653 TQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 709
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ N K +L + E + + E+AIK+ K + +
Sbjct: 710 RQLHEYETELEDER-NERALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 768
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 769 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 828
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 829 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 888
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 889 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 948
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 949 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1008
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1009 RINANRRKLQ 1018
Score = 44.4 bits (100), Expect = 0.001
Identities = 57/278 (20%), Positives = 128/278 (46%), Gaps = 22/278 (7%)
Query: 333 HSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
+S+ +++EQ ++A+ E E+ ++++ + Q ++E + E ++ E ++
Sbjct: 1 NSENLLQEQ-LQAETELYAEAEEMRVRLAA-----KKQELEEILHEMEARLEEEEDRGQQ 54
Query: 393 LKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNK 452
L+ Q DL+++L + + +L EK +IK L+DE++ +++ NK
Sbjct: 55 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV----MDDQNNK 110
Query: 453 LNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
L+ K ++E+ + T+L+ + LT + +S + +LE +++ +E
Sbjct: 111 LS-KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK----KEEKSRQ 165
Query: 512 ELTTYKNTLNNTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL--QNVEKE 568
EL K L + ++ + I + K L K+ + L + + +N +
Sbjct: 166 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 225
Query: 569 AYRELGTIKNELIEDVE---LLKKESNSQIKFLREEVE 603
REL ++L ED++ + ++ Q + L EE+E
Sbjct: 226 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 263
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 90.6 bits (215), Expect = 2e-17
Identities = 141/643 (21%), Positives = 276/643 (42%), Gaps = 43/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 343 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 401
Query: 149 ----RQSHNNIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+++H + F + R + + E + + G ++ + +R + +
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQ 459
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH 262
+E+ E+ + S+ ITV + K + + + L +T + E +K
Sbjct: 460 MEEMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 515
Query: 263 HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQM 321
L LE +++R+ + +E L ++ ++A + + + + N K +++E LK ++
Sbjct: 516 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
+ E+ ++L + + K KLE +E+ EK + + E + ++ +Q
Sbjct: 576 VSAS-ESRKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQ--- 628
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSD-LKQELN-NLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ E+E+ +LK L++ + N + LK L + K D L E IE ++ KD L
Sbjct: 629 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 688
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
I K E +KL + + K++ E +L + ++ + + LR+ + E LE +V
Sbjct: 689 ITKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEV 745
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTL 558
Q L E+LE ++ +N L + + L + K+ + K HT + E +
Sbjct: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXX 618
++S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 806 LDSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEV 859
Query: 619 XXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQ 678
L + DL +++N++ +L EL L R TV +
Sbjct: 860 NYQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELHLQRIN----PTTVKMK 913
Query: 679 SSIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
SS+ D+ K + LE + K + L + L+V K +S
Sbjct: 914 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS 956
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/521 (20%), Positives = 232/521 (44%), Gaps = 37/521 (7%)
Query: 99 ILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
+L + + ++ +D + +Y K+ ED+ +I+ LQE +K + + N +
Sbjct: 263 LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKE 322
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA--MINDMRSRIIELEKKCEALDNEVYD 216
EI K + + NT E + +A ++ +++ +I++ ++ + + E+ +
Sbjct: 323 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 382
Query: 217 -KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
KQ E S EE+ + ++ ++LQ++ + + QR+E E +R
Sbjct: 383 SKQKERQSSEEIKQLMGTV-EELQKRNHKDSQFETDIVQRMEQETQRKL------EQLRA 435
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E E ++ + KQ +I + E +KT+H +E+ E
Sbjct: 436 ELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY--SNITVNEDQIKL 490
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+ + E+ KL Q S EKLK EE ++E C+ Q + LE ++EL +
Sbjct: 491 MNVAINELNIKL-QDTNSQKEKLK------EELGLILEEKCALQRQ----LEDLVEELSF 539
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
+ + + ++ + L LST + + EI + + E + +E E +
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKI 598
Query: 456 AVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLEN 511
+E KEKN ++ ++ ++ + T L + EL +L++ +++ + +++ +N
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 658
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
YK ++ E + E + + +TK++ I+E ++ ++ LQ +
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKS 714
Query: 572 ELGTIK-NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E T++ NEL +++E+L++E + L +EV++ ++ E+
Sbjct: 715 EEMTLQINELQKEIEILRQEEKEK-GTLEQEVQELQLKTEL 754
Score = 76.6 bits (180), Expect = 3e-13
Identities = 113/530 (21%), Positives = 241/530 (45%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 539 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 598
Query: 215 YDKQMELSS---LEEVITVRDSLCKDLQEKLT-SNELTLAETQQRLEMVKGHHALALEA- 269
+ +E L+ + +++ + L+ +L S+E L++ ++ LE+ H + +E
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIEKL 655
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 711
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 880
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E ++E
Sbjct: 881 SKNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVVEK 936
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E L+ V K EL ++L E + K+ + +I FL EEV+
Sbjct: 937 DTTELMEKLE-VTKREKLELSQRLSDLSEQL----KQKHGEISFLNEEVK 981
Score = 73.7 bits (173), Expect = 2e-12
Identities = 110/494 (22%), Positives = 216/494 (43%), Gaps = 35/494 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTN 173
R KD+T+ E+ + E + Q Q+ L+ T +H++ + + K L
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQ-LQASETLRNSTHSSTAADLLQAKQQILT----- 272
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDS 233
H + Q E D +I L++K + + E DK++E S+ EE I +++
Sbjct: 273 -HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEE-IQEKET 329
Query: 234 LCKDLQEKLTSNELTLAETQQRL----EMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++L K+ E E + +L +++ ++ N+ I+ K+EL K K
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN-MKLELTNSKQKER 388
Query: 290 EEKQAIISKCKVDQENLKTKHNAS-IES-LKNQMLKEKCEALEQLHSQL--IIKEQEMKA 345
+ + I +E K H S E+ + +M +E LEQL ++L + +Q ++
Sbjct: 389 QSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM 448
Query: 346 KLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
K E I + + E++K E + + + E I+ + I EL L TN+Q
Sbjct: 449 KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL + K L + + +EE+ ++++ +++KLN E
Sbjct: 509 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN--------E 560
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTL-N 521
+K SLS D+ + + ES ELE + E +V E+LE E + +
Sbjct: 561 AHK---SLSTVEDLKAEI-VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ E + + L+ + + + KE I EH + + + N+ +++ ++NE+
Sbjct: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEI-EHRINIEKLKDNLGIHYKQQIDGLQNEMS 675
Query: 582 EDVELLKKESNSQI 595
+ +E ++ E ++ I
Sbjct: 676 QKIETMQFEKDNLI 689
Score = 36.3 bits (80), Expect = 0.38
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 50/323 (15%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIEDYKNEIAQ-LQEILKELATKFRQSHNNIDF 157
Q LV ++ E+ N+ Q E +Q E K + Q +QE+ +L T+ +
Sbjct: 706 QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL--QLKTELLEKQMKEKE 763
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK 217
N++ K ++L N+ E ++ D K+ ++ R+I L+ + V++K
Sbjct: 764 NDLQEKFAQLEAENSILKDEKKTLE--DMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEK 820
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM----VKGHHALALEANESI 273
++E+ +EE ++ C L E++ T + ++ E+ ++ +A L+ + +
Sbjct: 821 EIEIL-IEENEDLKQQ-CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 878
Query: 274 RR-------EYKIELEALKTKL-----------------DEEKQAIISKCKVDQ--ENLK 307
EYK +L+AL +L DE+K + ++ + E
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
Query: 308 TKHNASIESLK------NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
T+ +E K +Q L + E L+Q H ++ +E+K+ L+Q +E S + +
Sbjct: 939 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS-LKQEKEQVSLRCREL 997
Query: 362 EIQF-EERSQSIQEHCSQQEKTI 383
EI R++++Q C Q ++
Sbjct: 998 EIIINHNRAENVQS-CDTQVSSL 1019
>AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein.
Length = 3908
Score = 90.6 bits (215), Expect = 2e-17
Identities = 141/643 (21%), Positives = 276/643 (42%), Gaps = 43/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 343 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 401
Query: 149 ----RQSHNNIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+++H + F + R + + E + + G ++ + +R + +
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQ 459
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH 262
+E+ E+ + S+ ITV + K + + + L +T + E +K
Sbjct: 460 MEEMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 515
Query: 263 HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQM 321
L LE +++R+ + +E L ++ ++A + + + + N K +++E LK ++
Sbjct: 516 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
+ E+ ++L + + K KLE +E+ EK + + E + ++ +Q
Sbjct: 576 VSAS-ESRKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQ--- 628
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSD-LKQELN-NLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ E+E+ +LK L++ + N + LK L + K D L E IE ++ KD L
Sbjct: 629 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 688
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
I K E +KL + + K++ E +L + ++ + + LR+ + E LE +V
Sbjct: 689 ITKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEV 745
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTL 558
Q L E+LE ++ +N L + + L + K+ + K HT + E +
Sbjct: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXX 618
++S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 806 LDSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEV 859
Query: 619 XXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQ 678
L + DL +++N++ +L EL L R TV +
Sbjct: 860 NYQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELHLQRIN----PTTVKMK 913
Query: 679 SSIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
SS+ D+ K + LE + K + L + L+V K +S
Sbjct: 914 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS 956
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/521 (20%), Positives = 232/521 (44%), Gaps = 37/521 (7%)
Query: 99 ILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
+L + + ++ +D + +Y K+ ED+ +I+ LQE +K + + N +
Sbjct: 263 LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKE 322
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA--MINDMRSRIIELEKKCEALDNEVYD 216
EI K + + NT E + +A ++ +++ +I++ ++ + + E+ +
Sbjct: 323 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 382
Query: 217 -KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
KQ E S EE+ + ++ ++LQ++ + + QR+E E +R
Sbjct: 383 SKQKERQSSEEIKQLMGTV-EELQKRNHKDSQFETDIVQRMEQETQRKL------EQLRA 435
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E E ++ + KQ +I + E +KT+H +E+ E
Sbjct: 436 ELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY--SNITVNEDQIKL 490
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+ + E+ KL Q S EKLK EE ++E C+ Q + LE ++EL +
Sbjct: 491 MNVAINELNIKL-QDTNSQKEKLK------EELGLILEEKCALQRQ----LEDLVEELSF 539
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
+ + + ++ + L LST + + EI + + E + +E E +
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKI 598
Query: 456 AVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLEN 511
+E KEKN ++ ++ ++ + T L + EL +L++ +++ + +++ +N
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 658
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
YK ++ E + E + + +TK++ I+E ++ ++ LQ +
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKS 714
Query: 572 ELGTIK-NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E T++ NEL +++E+L++E + L +EV++ ++ E+
Sbjct: 715 EEMTLQINELQKEIEILRQEEKEK-GTLEQEVQELQLKTEL 754
Score = 74.1 bits (174), Expect = 2e-12
Identities = 113/530 (21%), Positives = 239/530 (45%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 539 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 598
Query: 215 YDKQMELSS---LEEVITVRDSLCKDLQEKLT-SNELTLAETQQRLEMVKGHHALALEA- 269
+ +E L+ + +++ + L+ +L S+E L++ ++ LE+ H + +E
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIEKL 655
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 711
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 880
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E ++E
Sbjct: 881 SKNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVVEK 936
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E L+ V K EL ++L E + K +I FL EEV+
Sbjct: 937 DTTELMEKLE-VTKREKLELSQRLSDLSEQL----KPKPGEISFLNEEVK 981
Score = 73.7 bits (173), Expect = 2e-12
Identities = 110/494 (22%), Positives = 216/494 (43%), Gaps = 35/494 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTN 173
R KD+T+ E+ + E + Q Q+ L+ T +H++ + + K L
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQ-LQASETLRNSTHSSTAADLLQAKQQILT----- 272
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDS 233
H + Q E D +I L++K + + E DK++E S+ EE I +++
Sbjct: 273 -HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEE-IQEKET 329
Query: 234 LCKDLQEKLTSNELTLAETQQRL----EMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++L K+ E E + +L +++ ++ N+ I+ K+EL K K
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN-MKLELTNSKQKER 388
Query: 290 EEKQAIISKCKVDQENLKTKHNAS-IES-LKNQMLKEKCEALEQLHSQL--IIKEQEMKA 345
+ + I +E K H S E+ + +M +E LEQL ++L + +Q ++
Sbjct: 389 QSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM 448
Query: 346 KLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
K E I + + E++K E + + + E I+ + I EL L TN+Q
Sbjct: 449 KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL + K L + + +EE+ ++++ +++KLN E
Sbjct: 509 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN--------E 560
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTL-N 521
+K SLS D+ + + ES ELE + E +V E+LE E + +
Sbjct: 561 AHK---SLSTVEDLKAEI-VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ E + + L+ + + + KE I EH + + + N+ +++ ++NE+
Sbjct: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEI-EHRINIEKLKDNLGIHYKQQIDGLQNEMS 675
Query: 582 EDVELLKKESNSQI 595
+ +E ++ E ++ I
Sbjct: 676 QKIETMQFEKDNLI 689
Score = 69.7 bits (163), Expect = 3e-11
Identities = 110/485 (22%), Positives = 227/485 (46%), Gaps = 50/485 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF---RQSHNN--ID 156
+ +L+Q + ++ K + C+ K +D + ++ L+ ++E ++F Q N +D
Sbjct: 1992 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2051
Query: 157 FNE----IDRKLSKLR--INNTNCHTEHNA-VQGTDAEKVSAMINDMR--SRIIELE-KK 206
+ ++++L K+R ++ EH V + +K+ + + I E + ++
Sbjct: 2052 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2111
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQRLEMVKGHH 263
E L N + +K + S E++ ++ L +D+QE+ + E + E +Q L +V
Sbjct: 2112 VEQLANHLKEKTDKCS---ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-LVSADT 2167
Query: 264 ALALEANESIRR-EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
+E + E K EL +L+ +L E+ AI K K + NL+ + E L+N
Sbjct: 2168 FQKVEDRKHFGAVEAKPEL-SLEVQLQAERDAIDRKEK-EITNLEEQLEQFREELEN--- 2222
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH--CSQQE 380
K E ++QLH QL I+++E +L+++E ++ K+ + E+ +I+E S Q+
Sbjct: 2223 --KNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLGLAIKESDAMSTQD 2276
Query: 381 KTIQY--LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT---- 434
+ + + Q I+E + +D N Q + L+Q+L + +++ EK I +++T
Sbjct: 2277 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIEC 2334
Query: 435 -LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+ D+ K N E E +LN +EK +E S+ H L+ +L+
Sbjct: 2335 LMSDQECVKR-NREEEIEQLNEVIEKLQQELANIGQKTSMN---AHSLSEEADSLKHQLD 2390
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ + L E E+T KN L T + ++ + L ++ + + ++ K + I E
Sbjct: 2391 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IPE 2449
Query: 554 HNVTL 558
++V +
Sbjct: 2450 NSVNV 2454
Score = 62.5 bits (145), Expect = 5e-09
Identities = 83/418 (19%), Positives = 188/418 (44%), Gaps = 27/418 (6%)
Query: 198 SRIIELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN-ELTLAETQQ 254
+R+ ELE + + + + E+ +Q E E V L ++ ++ + E+ +
Sbjct: 1958 NRLQELEAEQQQIQEERELLSRQKEAMKAEAG-PVEQQLLQETEKLMKEKLEVQCQAEKV 2016
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLD--EEKQAI---ISKCK--VDQENLK 307
R ++ K AL ++ E + R ++E E +D ++ QA+ + K + +D++ +
Sbjct: 2017 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2076
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H + + Q L+++ + + + I E + + ++EQ+ EK C
Sbjct: 2077 REHERDVFQQEIQKLEQQLKVVPRFQP---ISEHQTR-EVEQLANHLKEKTDKCSELLLS 2132
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q +Q ++ + I+ LE ++EL+ L ++ +D Q++ + K+ + + +
Sbjct: 2133 KEQ-LQRDIQERNEEIEKLEFRVRELEQALLVS----ADTFQKVEDRKHFGAVEAKPELS 2187
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLR 486
+++ +D + K N + +L E+ ++ KN+ L + +I T RL+
Sbjct: 2188 LEVQLQAERDAIDRKEKEITNLEEQLEQFREE-LENKNEEVQQLHMQLEIQKKESTTRLQ 2246
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
E + E + +D ++ L A + + T ++ L + + KE ++ L + +
Sbjct: 2247 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2306
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ +I N + E + E R+L T L+ D E +K+ +I+ L E +EK
Sbjct: 2307 QQLKITTDNKVIEE-----KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2359
Score = 54.8 bits (126), Expect = 1e-06
Identities = 92/405 (22%), Positives = 184/405 (45%), Gaps = 42/405 (10%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
+SSL+++IT + L ++ E S++ + + R E++ + LE + ++ E
Sbjct: 2992 ISSLKDLIT-KMQLQREA-EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTE 3049
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL---- 336
L AL T + +++ + + ++ A++E L+ + ++ LH+Q+
Sbjct: 3050 LTALGTT---DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 3106
Query: 337 --IIKEQEM-KAKLEQIEESASEKL-KICEIQFE-----ERSQSIQEHCSQQEKTIQYLE 387
+ +EQE K E +E + +K ++ E+Q E +R+ +QE S ++ + L+
Sbjct: 3107 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 3166
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
E+ + K L+ T LK + +LK EL E F + KT + L+ T+ E
Sbjct: 3167 SELAQTKLELETT------LKAQHKHLK----EL--EAFRLEVKDKTDEVHLLNDTLASE 3214
Query: 448 NEKNK-LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ----LEDQVQML 502
+K++ L A+E KEK K S ++ + L L Q LE Q Q+L
Sbjct: 3215 QKKSRELQWALE---KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3271
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
+++ +E++ Y L+ E E V +L+S+ +E + ++ L L
Sbjct: 3272 NESQQKIESQRMLYDAQLS---EEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQL 3327
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
Q+ + +L+++++ +E +S+I L E EK ++
Sbjct: 3328 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3372
Score = 54.4 bits (125), Expect = 1e-06
Identities = 103/504 (20%), Positives = 219/504 (43%), Gaps = 48/504 (9%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+ I E + Q+E K + Q E+++E FRQ + + +L + R++ + E
Sbjct: 1860 EAISETSSQLEHAK--VTQT-ELMRE---SFRQKQEATESLKCQEELRE-RLHEESRARE 1912
Query: 178 HNAVQGTDAEKVSAMINDMRSRII-ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
AV+ + AE V D ++ ++++K + +D + + L+E+ ++ +
Sbjct: 1913 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL----EAEQQ 1968
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
+QE+ L+ + + E L E + ++ + +++ +A K + D +KQ
Sbjct: 1969 QIQEE--RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2026
Query: 297 SKCKVDQE-----NLKTKHNASIESLK--NQMLKEKCEALEQ-LHSQLIIKEQEMKAKLE 348
+ V+++ L+ + N + L+ NQ L+++ E + + L Q I +E E +
Sbjct: 2027 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQ 2086
Query: 349 QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+I++ ++LK+ R Q I EH +++ +EQ LK D + +
Sbjct: 2087 EIQK-LEQQLKVVP-----RFQPISEHQTRE------VEQLANHLKEKTDKCSELLLSKE 2134
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
Q +++ +E+ EK F ++ L+ L+ ++ +++ + +A K + E
Sbjct: 2135 QLQRDIQERNEEI--EKLEF--RVRELEQALLVSADTFQKVEDRKHFGAVEA-KPELSLE 2189
Query: 469 TSLSVTRDIV-----HVLTL--RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
L RD + + L +L + ELE ++VQ L E+ + E TT L
Sbjct: 2190 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE 2249
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT-IKNEL 580
+ + E L +K A++ + ++ I + VE + E T ++ +L
Sbjct: 2250 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2309
Query: 581 -IEDVELLKKESNSQIKFLREEVE 603
I + +E N I+ L ++E
Sbjct: 2310 KITTDNKVIEEKNELIRDLETQIE 2333
Score = 54.0 bits (124), Expect = 2e-06
Identities = 101/516 (19%), Positives = 213/516 (41%), Gaps = 47/516 (9%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
D L DV I K +Q+E E+ ++ +LKE N N++ +
Sbjct: 2383 DSLKHQLDVVIAEK----LALEQQVETANEEMTFMKNVLKE---------TNFKMNQLTQ 2429
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEVYDKQMEL 221
+L L+ + + + + + + D ++ E ++L+N+ Y K E
Sbjct: 2430 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2489
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-NESIRREYKIE 280
+ +I + L + L+ +++ +L L + ++++ ++ E + I KI
Sbjct: 2490 NGKGSIINLETRLLQ-LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2548
Query: 281 LEALKTKLDEEKQ--AIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
E + L + Q A+ K Q+N +++N L+E + L S L
Sbjct: 2549 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALT 2606
Query: 338 IKEQEMKAKLEQIEESA---SEKLKICEIQFEERSQSIQE--------HCSQQEKTIQYL 386
++ E+++++ ++ S E+++I E E+ + + E Q+EK +
Sbjct: 2607 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2666
Query: 387 EQEIKELKYTLDLTN-NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
Q+++ LK T +L + N+ S EL L+ E ++ E+ + L++EL+ K N
Sbjct: 2667 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2726
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+ + L+ + + K K S+ D V +S+ + + + + S
Sbjct: 2727 MTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEV-------QESKKACMFEPLPIKLSK 2777
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
+ + T ++ N T + K A + I ++E T I+ IE +Q +
Sbjct: 2778 SIASQTDGTLKISSSNQTPQIL--VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2835
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREE 601
E+ +++ I + E LK+E ++ L+EE
Sbjct: 2836 HAA---EILDMESRHISETETLKREHYVAVQLLKEE 2868
Score = 45.6 bits (103), Expect = 6e-04
Identities = 97/457 (21%), Positives = 198/457 (43%), Gaps = 37/457 (8%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVE---IRNKDQTICEYNKQIEDYKNEIAQLQEILKEL 144
I T K+ + +D+ A+ +E + KD T E +++E K E +L + L +L
Sbjct: 905 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT--ELMEKLEVTKREKLELSQRLSDL 962
Query: 145 ATKFRQSHNNIDF-NEIDRKLS------KLRINNTNCHTEHNAVQGTDA--EKVSAMIND 195
+ + + I F NE + L LR HN + + +VS++++
Sbjct: 963 SEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEKLTSNEL--TLAET 252
+ + + + N+ + ++ ++ ++V ++ ++ QE+L + L E+
Sbjct: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1082
Query: 253 QQRLEMVKGHHALALEAN--ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
R + L E N +S + + ++++EA + L + + + EN K K
Sbjct: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ---FEE 367
S++ +EK + L+++H ++ Q MK + E +E L I ++Q EE
Sbjct: 1143 LCSLKEELIFAQEEKIKELQKIHQ---LELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1198
Query: 368 RSQSIQEHCSQQ-EKTIQYLEQEI--KELKYTLD-LTNNQNSDLKQELNNLKNCKDELST 423
S +Q CS E L+ E+ ++ + + D ++ N++ +L+ +++ ++ + T
Sbjct: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258
Query: 424 EKFNFIEEIKTLK--DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS-VTR----D 476
EE L + K + + KL E KE+ +F + S +T D
Sbjct: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
Query: 477 IVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
+ H L + + +QLE+QVQ L S L+ +L
Sbjct: 1319 VNHKSKLSSLQDLEKTKQLEEQVQELESLISSLQQQL 1355
Score = 37.1 bits (82), Expect = 0.22
Identities = 64/339 (18%), Positives = 146/339 (43%), Gaps = 31/339 (9%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDF 157
Q ++++ Q VE+ + E +Q+ K +A+L+ L EL T + H ++
Sbjct: 3131 QSQMLEMQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3189
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK----CEALDNE 213
E R K + + + + A + + ++ + ++++ E++ E L
Sbjct: 3190 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3249
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT----LAETQQR-LEM---VKGHHAL 265
+ ++ L ++ + L + Q+K+ S + L+E Q R LE+ ++
Sbjct: 3250 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 3309
Query: 266 ALEANESIRREYKIELEALKTK-LDEEKQAIISK--CKVDQENLKTKHNASIESLKNQML 322
E + ++ RE ++ + + + + + S+ K Q+ L+ KH+ +E L N+
Sbjct: 3310 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELL-NETE 3368
Query: 323 KEKCEALE---------QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
K K ++L+ Q+H + + EQE + ++ K++ + Q EE+ Q +
Sbjct: 3369 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3428
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ + + +Q + QE ++ + + L Q LN
Sbjct: 3429 K-LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN 3466
Score = 35.5 bits (78), Expect = 0.67
Identities = 78/363 (21%), Positives = 155/363 (42%), Gaps = 46/363 (12%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQ----IEDYKNEIAQLQEILKELATKFRQS 151
+ ++L + V A+D+E+ + I + +Q E + +I LQ+I++E S
Sbjct: 2499 ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2558
Query: 152 HNNIDFNEIDRKLSKLRINNT-NCHTEHNAVQGTDA---EKVSAMINDMRSRIIELEKKC 207
I + + N T + E +Q + +++ + I+ + RI ELE +
Sbjct: 2559 Q--IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQV 2616
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + ++ ++ E+ + ++ +LQ+ L N E +QR
Sbjct: 2617 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN-----EKKQR------------ 2659
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
E ++ ++E LKT + S + E L+ + A+ L + KEK E
Sbjct: 2660 ---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAE 2714
Query: 328 ALEQLHSQLIIKEQEM---KAKLEQIEE---SASEKLKICEIQFEERSQSIQEHCSQQEK 381
L++ +L++KE M + L Q+ + A EKL I E + E Q ++ C +
Sbjct: 2715 KLQE---ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2771
Query: 382 TIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKTLKDEL 439
I+ + + TL + ++NQ + + ++ N + E S+E+ + EI + E
Sbjct: 2772 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE---VTEIISQFTEK 2828
Query: 440 IEK 442
IEK
Sbjct: 2829 IEK 2831
Score = 31.9 bits (69), Expect = 8.3
Identities = 26/119 (21%), Positives = 59/119 (49%), Gaps = 12/119 (10%)
Query: 275 REYKIELEALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH 333
++++ + L K+ EE + ++ + ++ + + +E + + KE+ E L +H
Sbjct: 1250 QDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS-IH 1308
Query: 334 SQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
SQ+ LE I+ + K K+ +Q E+++ ++E + E I L+Q++KE
Sbjct: 1309 SQM--------TNLEDID--VNHKSKLSSLQDLEKTKQLEEQVQELESLISSLQQQLKE 1357
>AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein.
Length = 3911
Score = 90.6 bits (215), Expect = 2e-17
Identities = 141/643 (21%), Positives = 276/643 (42%), Gaps = 43/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 355 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 413
Query: 149 ----RQSHNNIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+++H + F + R + + E + + G ++ + +R + +
Sbjct: 414 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQ 471
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH 262
+E+ E+ + S+ ITV + K + + + L +T + E +K
Sbjct: 472 MEEMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 527
Query: 263 HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQM 321
L LE +++R+ + +E L ++ ++A + + + + N K +++E LK ++
Sbjct: 528 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 587
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
+ E+ ++L + + K KLE +E+ EK + + E + ++ +Q
Sbjct: 588 VSAS-ESRKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQ--- 640
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSD-LKQELN-NLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ E+E+ +LK L++ + N + LK L + K D L E IE ++ KD L
Sbjct: 641 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 700
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
I K E +KL + + K++ E +L + ++ + + LR+ + E LE +V
Sbjct: 701 ITKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEV 757
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTL 558
Q L E+LE ++ +N L + + L + K+ + K HT + E +
Sbjct: 758 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 817
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXX 618
++S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 818 LDSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEV 871
Query: 619 XXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQ 678
L + DL +++N++ +L EL L R TV +
Sbjct: 872 NYQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELHLQRIN----PTTVKMK 925
Query: 679 SSIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
SS+ D+ K + LE + K + L + L+V K +S
Sbjct: 926 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS 968
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/521 (20%), Positives = 232/521 (44%), Gaps = 37/521 (7%)
Query: 99 ILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
+L + + ++ +D + +Y K+ ED+ +I+ LQE +K + + N +
Sbjct: 275 LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKE 334
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA--MINDMRSRIIELEKKCEALDNEVYD 216
EI K + + NT E + +A ++ +++ +I++ ++ + + E+ +
Sbjct: 335 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 394
Query: 217 -KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
KQ E S EE+ + ++ ++LQ++ + + QR+E E +R
Sbjct: 395 SKQKERQSSEEIKQLMGTV-EELQKRNHKDSQFETDIVQRMEQETQRKL------EQLRA 447
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E E ++ + KQ +I + E +KT+H +E+ E
Sbjct: 448 ELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY--SNITVNEDQIKL 502
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+ + E+ KL Q S EKLK EE ++E C+ Q + LE ++EL +
Sbjct: 503 MNVAINELNIKL-QDTNSQKEKLK------EELGLILEEKCALQRQ----LEDLVEELSF 551
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
+ + + ++ + L LST + + EI + + E + +E E +
Sbjct: 552 SREQIQRARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKI 610
Query: 456 AVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLEN 511
+E KEKN ++ ++ ++ + T L + EL +L++ +++ + +++ +N
Sbjct: 611 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 670
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
YK ++ E + E + + +TK++ I+E ++ ++ LQ +
Sbjct: 671 LGIHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKS 726
Query: 572 ELGTIK-NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E T++ NEL +++E+L++E + L +EV++ ++ E+
Sbjct: 727 EEMTLQINELQKEIEILRQEEKEK-GTLEQEVQELQLKTEL 766
Score = 76.6 bits (180), Expect = 3e-13
Identities = 113/530 (21%), Positives = 241/530 (45%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 491 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 550
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 551 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 610
Query: 215 YDKQMELSS---LEEVITVRDSLCKDLQEKLT-SNELTLAETQQRLEMVKGHHALALEA- 269
+ +E L+ + +++ + L+ +L S+E L++ ++ LE+ H + +E
Sbjct: 611 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIEKL 667
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 668 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 723
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 724 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 783
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 784 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 843
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 844 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 892
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E ++E
Sbjct: 893 SKNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVVEK 948
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E L+ V K EL ++L E + K+ + +I FL EEV+
Sbjct: 949 DTTELMEKLE-VTKREKLELSQRLSDLSEQL----KQKHGEISFLNEEVK 993
Score = 73.7 bits (173), Expect = 2e-12
Identities = 110/494 (22%), Positives = 216/494 (43%), Gaps = 35/494 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTN 173
R KD+T+ E+ + E + Q Q+ L+ T +H++ + + K L
Sbjct: 231 REKDETMREFLELTEQSQKLQIQFQQ-LQASETLRNSTHSSTAADLLQAKQQILT----- 284
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDS 233
H + Q E D +I L++K + + E DK++E S+ EE I +++
Sbjct: 285 -HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEE-IQEKET 341
Query: 234 LCKDLQEKLTSNELTLAETQQRL----EMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++L K+ E E + +L +++ ++ N+ I+ K+EL K K
Sbjct: 342 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN-MKLELTNSKQKER 400
Query: 290 EEKQAIISKCKVDQENLKTKHNAS-IES-LKNQMLKEKCEALEQLHSQL--IIKEQEMKA 345
+ + I +E K H S E+ + +M +E LEQL ++L + +Q ++
Sbjct: 401 QSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM 460
Query: 346 KLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
K E I + + E++K E + + + E I+ + I EL L TN+Q
Sbjct: 461 KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 520
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL + K L + + +EE+ ++++ +++KLN E
Sbjct: 521 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN--------E 572
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTL-N 521
+K SLS D+ + + ES ELE + E +V E+LE E + +
Sbjct: 573 AHK---SLSTVEDLKAEI-VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 628
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ E + + L+ + + + KE I EH + + + N+ +++ ++NE+
Sbjct: 629 SQEAELERLRTQLLFSHEEELSKLKEDLEI-EHRINIEKLKDNLGIHYKQQIDGLQNEMS 687
Query: 582 EDVELLKKESNSQI 595
+ +E ++ E ++ I
Sbjct: 688 QKIETMQFEKDNLI 701
Score = 69.7 bits (163), Expect = 3e-11
Identities = 110/485 (22%), Positives = 227/485 (46%), Gaps = 50/485 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF---RQSHNN--ID 156
+ +L+Q + ++ K + C+ K +D + ++ L+ ++E ++F Q N +D
Sbjct: 2003 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2062
Query: 157 FNE----IDRKLSKLR--INNTNCHTEHNA-VQGTDAEKVSAMINDMR--SRIIELE-KK 206
+ ++++L K+R ++ EH V + +K+ + + I E + ++
Sbjct: 2063 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2122
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQRLEMVKGHH 263
E L N + +K + S E++ ++ L +D+QE+ + E + E +Q L +V
Sbjct: 2123 VEQLANHLKEKTDKCS---ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-LVSADT 2178
Query: 264 ALALEANESIRR-EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
+E + E K EL +L+ +L E+ AI K K + NL+ + E L+N
Sbjct: 2179 FQKVEDRKHFGAVEAKPEL-SLEVQLQAERDAIDRKEK-EITNLEEQLEQFREELEN--- 2233
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH--CSQQE 380
K E ++QLH QL I+++E +L+++E ++ K+ + E+ +I+E S Q+
Sbjct: 2234 --KNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLGLAIKESDAMSTQD 2287
Query: 381 KTIQY--LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT---- 434
+ + + Q I+E + +D N Q + L+Q+L + +++ EK I +++T
Sbjct: 2288 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIEC 2345
Query: 435 -LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+ D+ K N E E +LN +EK +E S+ H L+ +L+
Sbjct: 2346 LMSDQECVKR-NREEEIEQLNEVIEKLQQELANIGQKTSMN---AHSLSEEADSLKHQLD 2401
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ + L E E+T KN L T + ++ + L ++ + + ++ K + I E
Sbjct: 2402 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IPE 2460
Query: 554 HNVTL 558
++V +
Sbjct: 2461 NSVNV 2465
Score = 62.5 bits (145), Expect = 5e-09
Identities = 83/418 (19%), Positives = 188/418 (44%), Gaps = 27/418 (6%)
Query: 198 SRIIELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN-ELTLAETQQ 254
+R+ ELE + + + + E+ +Q E E V L ++ ++ + E+ +
Sbjct: 1969 NRLQELEAEQQQIQEERELLSRQKEAMKAEAG-PVEQQLLQETEKLMKEKLEVQCQAEKV 2027
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLD--EEKQAI---ISKCK--VDQENLK 307
R ++ K AL ++ E + R ++E E +D ++ QA+ + K + +D++ +
Sbjct: 2028 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2087
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H + + Q L+++ + + + I E + + ++EQ+ EK C
Sbjct: 2088 REHERDVFQQEIQKLEQQLKVVPRFQP---ISEHQTR-EVEQLANHLKEKTDKCSELLLS 2143
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q +Q ++ + I+ LE ++EL+ L ++ +D Q++ + K+ + + +
Sbjct: 2144 KEQ-LQRDIQERNEEIEKLEFRVRELEQALLVS----ADTFQKVEDRKHFGAVEAKPELS 2198
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLR 486
+++ +D + K N + +L E+ ++ KN+ L + +I T RL+
Sbjct: 2199 LEVQLQAERDAIDRKEKEITNLEEQLEQFREE-LENKNEEVQQLHMQLEIQKKESTTRLQ 2257
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
E + E + +D ++ L A + + T ++ L + + KE ++ L + +
Sbjct: 2258 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2317
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ +I N + E + E R+L T L+ D E +K+ +I+ L E +EK
Sbjct: 2318 QQLKITTDNKVIEE-----KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2370
Score = 54.8 bits (126), Expect = 1e-06
Identities = 92/405 (22%), Positives = 184/405 (45%), Gaps = 42/405 (10%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
+SSL+++IT + L ++ E S++ + + R E++ + LE + ++ E
Sbjct: 2995 ISSLKDLIT-KMQLQREA-EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTE 3052
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL---- 336
L AL T + +++ + + ++ A++E L+ + ++ LH+Q+
Sbjct: 3053 LTALGTT---DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 3109
Query: 337 --IIKEQEM-KAKLEQIEESASEKL-KICEIQFE-----ERSQSIQEHCSQQEKTIQYLE 387
+ +EQE K E +E + +K ++ E+Q E +R+ +QE S ++ + L+
Sbjct: 3110 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 3169
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
E+ + K L+ T LK + +LK EL E F + KT + L+ T+ E
Sbjct: 3170 SELAQTKLELETT------LKAQHKHLK----EL--EAFRLEVKDKTDEVHLLNDTLASE 3217
Query: 448 NEKNK-LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ----LEDQVQML 502
+K++ L A+E KEK K S ++ + L L Q LE Q Q+L
Sbjct: 3218 QKKSRELQWALE---KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3274
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
+++ +E++ Y L+ E E V +L+S+ +E + ++ L L
Sbjct: 3275 NESQQKIESQRMLYDAQLS---EEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQL 3330
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
Q+ + +L+++++ +E +S+I L E EK ++
Sbjct: 3331 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3375
Score = 54.4 bits (125), Expect = 1e-06
Identities = 103/504 (20%), Positives = 219/504 (43%), Gaps = 48/504 (9%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+ I E + Q+E K + Q E+++E FRQ + + +L + R++ + E
Sbjct: 1871 EAISETSSQLEHAK--VTQT-ELMRE---SFRQKQEATESLKCQEELRE-RLHEESRARE 1923
Query: 178 HNAVQGTDAEKVSAMINDMRSRII-ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
AV+ + AE V D ++ ++++K + +D + + L+E+ ++ +
Sbjct: 1924 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL----EAEQQ 1979
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
+QE+ L+ + + E L E + ++ + +++ +A K + D +KQ
Sbjct: 1980 QIQEE--RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2037
Query: 297 SKCKVDQE-----NLKTKHNASIESLK--NQMLKEKCEALEQ-LHSQLIIKEQEMKAKLE 348
+ V+++ L+ + N + L+ NQ L+++ E + + L Q I +E E +
Sbjct: 2038 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQ 2097
Query: 349 QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+I++ ++LK+ R Q I EH +++ +EQ LK D + +
Sbjct: 2098 EIQK-LEQQLKVVP-----RFQPISEHQTRE------VEQLANHLKEKTDKCSELLLSKE 2145
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
Q +++ +E+ EK F ++ L+ L+ ++ +++ + +A K + E
Sbjct: 2146 QLQRDIQERNEEI--EKLEF--RVRELEQALLVSADTFQKVEDRKHFGAVEA-KPELSLE 2200
Query: 469 TSLSVTRDIV-----HVLTL--RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
L RD + + L +L + ELE ++VQ L E+ + E TT L
Sbjct: 2201 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE 2260
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT-IKNEL 580
+ + E L +K A++ + ++ I + VE + E T ++ +L
Sbjct: 2261 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2320
Query: 581 -IEDVELLKKESNSQIKFLREEVE 603
I + +E N I+ L ++E
Sbjct: 2321 KITTDNKVIEEKNELIRDLETQIE 2344
Score = 54.0 bits (124), Expect = 2e-06
Identities = 101/516 (19%), Positives = 213/516 (41%), Gaps = 47/516 (9%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
D L DV I K +Q+E E+ ++ +LKE N N++ +
Sbjct: 2394 DSLKHQLDVVIAEK----LALEQQVETANEEMTFMKNVLKE---------TNFKMNQLTQ 2440
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEVYDKQMEL 221
+L L+ + + + + + + D ++ E ++L+N+ Y K E
Sbjct: 2441 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2500
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-NESIRREYKIE 280
+ +I + L + L+ +++ +L L + ++++ ++ E + I KI
Sbjct: 2501 NGKGSIINLETRLLQ-LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2559
Query: 281 LEALKTKLDEEKQ--AIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
E + L + Q A+ K Q+N +++N L+E + L S L
Sbjct: 2560 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALT 2617
Query: 338 IKEQEMKAKLEQIEESA---SEKLKICEIQFEERSQSIQE--------HCSQQEKTIQYL 386
++ E+++++ ++ S E+++I E E+ + + E Q+EK +
Sbjct: 2618 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2677
Query: 387 EQEIKELKYTLDLTN-NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
Q+++ LK T +L + N+ S EL L+ E ++ E+ + L++EL+ K N
Sbjct: 2678 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2737
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+ + L+ + + K K S+ D V +S+ + + + + S
Sbjct: 2738 MTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEV-------QESKKACMFEPLPIKLSK 2788
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
+ + T ++ N T + K A + I ++E T I+ IE +Q +
Sbjct: 2789 SIASQTDGTLKISSSNQTPQIL--VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2846
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREE 601
E+ +++ I + E LK+E ++ L+EE
Sbjct: 2847 HAA---EILDMESRHISETETLKREHYVAVQLLKEE 2879
Score = 53.6 bits (123), Expect = 2e-06
Identities = 101/488 (20%), Positives = 217/488 (44%), Gaps = 39/488 (7%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVE---IRNKDQTICEYNKQIEDYKNEIAQLQEILKEL 144
I T K+ + +D+ A+ +E + KD T E +++E K E +L + L +L
Sbjct: 917 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT--ELMEKLEVTKREKLELSQRLSDL 974
Query: 145 ATKFRQSHNNIDF-NEIDRKLSK------LRINNTNCHTEHNAVQGTDA--EKVSAMIND 195
+ + +Q H I F NE + L + LR HN + + +VS++++
Sbjct: 975 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1034
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEKLTSNEL--TLAET 252
+ + + + N+ + ++ ++ ++V ++ ++ QE+L + L E+
Sbjct: 1035 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1094
Query: 253 QQRLEMVKGHHALALEAN--ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
R + L E N +S + + ++++EA + L + + + EN K K
Sbjct: 1095 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1154
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ---FEE 367
S++ +EK + L+++H ++ Q MK + E +E L I ++Q EE
Sbjct: 1155 LCSLKEELIFAQEEKIKELQKIHQ---LELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1210
Query: 368 RSQSIQEHCS-QQEKTIQYLEQEI--KELKYTLD-LTNNQNSDLKQELNNLKNCKDELST 423
S +Q CS E L+ E+ ++ + + D ++ N++ +L+ +++ ++ + T
Sbjct: 1211 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1270
Query: 424 EKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
EE L + K + + KL E KE+ +F LS+ + ++
Sbjct: 1271 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLE 1327
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ + S+L L+D + T +E ++ EL + ++L ++E ++ EA ++ L+ +
Sbjct: 1328 DIDVNHK-SKLSSLQDLEK--TKLEEQVQ-ELESLISSLQQQLKETEQNYEAEIHCLQKR 1383
Query: 542 AALTKEHT 549
E T
Sbjct: 1384 LQAVSEST 1391
Score = 37.1 bits (82), Expect = 0.22
Identities = 64/339 (18%), Positives = 146/339 (43%), Gaps = 31/339 (9%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDF 157
Q ++++ Q VE+ + E +Q+ K +A+L+ L EL T + H ++
Sbjct: 3134 QSQMLEMQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3192
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK----CEALDNE 213
E R K + + + + A + + ++ + ++++ E++ E L
Sbjct: 3193 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3252
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT----LAETQQR-LEM---VKGHHAL 265
+ ++ L ++ + L + Q+K+ S + L+E Q R LE+ ++
Sbjct: 3253 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 3312
Query: 266 ALEANESIRREYKIELEALKTK-LDEEKQAIISK--CKVDQENLKTKHNASIESLKNQML 322
E + ++ RE ++ + + + + + S+ K Q+ L+ KH+ +E L N+
Sbjct: 3313 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELL-NETE 3371
Query: 323 KEKCEALE---------QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
K K ++L+ Q+H + + EQE + ++ K++ + Q EE+ Q +
Sbjct: 3372 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3431
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ + + +Q + QE ++ + + L Q LN
Sbjct: 3432 K-LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN 3469
Score = 36.3 bits (80), Expect = 0.38
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 50/323 (15%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIEDYKNEIAQ-LQEILKELATKFRQSHNNIDF 157
Q LV ++ E+ N+ Q E +Q E K + Q +QE+ +L T+ +
Sbjct: 718 QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL--QLKTELLEKQMKEKE 775
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK 217
N++ K ++L N+ E ++ D K+ ++ R+I L+ + V++K
Sbjct: 776 NDLQEKFAQLEAENSILKDEKKTLE--DMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEK 832
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM----VKGHHALALEANESI 273
++E+ +EE ++ C L E++ T + ++ E+ ++ +A L+ + +
Sbjct: 833 EIEIL-IEENEDLKQQ-CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 890
Query: 274 RR-------EYKIELEALKTKL-----------------DEEKQAIISKCKVDQ--ENLK 307
EYK +L+AL +L DE+K + ++ + E
Sbjct: 891 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 950
Query: 308 TKHNASIESLK------NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
T+ +E K +Q L + E L+Q H ++ +E+K+ L+Q +E S + +
Sbjct: 951 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS-LKQEKEQVSLRCREL 1009
Query: 362 EIQF-EERSQSIQEHCSQQEKTI 383
EI R++++Q C Q ++
Sbjct: 1010 EIIINHNRAENVQS-CDTQVSSL 1031
Score = 35.5 bits (78), Expect = 0.67
Identities = 78/363 (21%), Positives = 155/363 (42%), Gaps = 46/363 (12%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQ----IEDYKNEIAQLQEILKELATKFRQS 151
+ ++L + V A+D+E+ + I + +Q E + +I LQ+I++E S
Sbjct: 2510 ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2569
Query: 152 HNNIDFNEIDRKLSKLRINNT-NCHTEHNAVQGTDA---EKVSAMINDMRSRIIELEKKC 207
I + + N T + E +Q + +++ + I+ + RI ELE +
Sbjct: 2570 Q--IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQV 2627
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + ++ ++ E+ + ++ +LQ+ L N E +QR
Sbjct: 2628 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN-----EKKQR------------ 2670
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
E ++ ++E LKT + S + E L+ + A+ L + KEK E
Sbjct: 2671 ---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAE 2725
Query: 328 ALEQLHSQLIIKEQEM---KAKLEQIEE---SASEKLKICEIQFEERSQSIQEHCSQQEK 381
L++ +L++KE M + L Q+ + A EKL I E + E Q ++ C +
Sbjct: 2726 KLQE---ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2782
Query: 382 TIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKTLKDEL 439
I+ + + TL + ++NQ + + ++ N + E S+E+ + EI + E
Sbjct: 2783 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE---VTEIISQFTEK 2839
Query: 440 IEK 442
IEK
Sbjct: 2840 IEK 2842
>AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring protein
AKAP350 protein.
Length = 3595
Score = 90.6 bits (215), Expect = 2e-17
Identities = 141/643 (21%), Positives = 276/643 (42%), Gaps = 43/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 33 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 91
Query: 149 ----RQSHNNIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+++H + F + R + + E + + G ++ + +R + +
Sbjct: 92 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQ 149
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH 262
+E+ E+ + S+ ITV + K + + + L +T + E +K
Sbjct: 150 MEEMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 205
Query: 263 HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQM 321
L LE +++R+ + +E L ++ ++A + + + + N K +++E LK ++
Sbjct: 206 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 265
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
+ E+ ++L + + K KLE +E+ EK + + E + ++ +Q
Sbjct: 266 VSAS-ESRKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQ--- 318
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSD-LKQELN-NLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ E+E+ +LK L++ + N + LK L + K D L E IE ++ KD L
Sbjct: 319 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 378
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
I K E +KL + + K++ E +L + ++ + + LR+ + E LE +V
Sbjct: 379 ITKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEV 435
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTL 558
Q L E+LE ++ +N L + + L + K+ + K HT + E +
Sbjct: 436 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 495
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXX 618
++S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 496 LDSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEV 549
Query: 619 XXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQ 678
L + DL +++N++ +L EL L R TV +
Sbjct: 550 NYQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELHLQRIN----PTTVKMK 603
Query: 679 SSIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
SS+ D+ K + LE + K + L + L+V K +S
Sbjct: 604 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS 646
Score = 81.8 bits (193), Expect = 8e-15
Identities = 93/447 (20%), Positives = 212/447 (47%), Gaps = 35/447 (7%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+ ++ +I ++ ++IIE EKK L +++ L L+E I ++ K+++ +LT+
Sbjct: 13 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 72
Query: 245 NELTLAETQQRLEMVKG---------HHALALEAN--ESIRREYKIELEALKTKLDEEKQ 293
++ ++ + ++ + G H E + + + +E + +LE L+ +LDE
Sbjct: 73 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 132
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
I + K + L +H A +E +K + E AL +S + + E ++K I E
Sbjct: 133 QQIVQMK---QELIRQHMAQMEEMKTRHKGEMENALRS-YSNITVNEDQIKLMNVAINE- 187
Query: 354 ASEKLKICEIQFEERSQS----IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
+ KL+ Q E+ + ++E C+ Q + LE ++EL ++ + + +
Sbjct: 188 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQ----LEDLVEELSFSREQIQRARQTIAE 243
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
+ + L LST + + EI + + E + +E E + +E KEKN
Sbjct: 244 QESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD 302
Query: 470 SLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLENELTTYKNTLNNTVR 525
++ ++ ++ + T L + EL +L++ +++ + +++ +N YK ++
Sbjct: 303 RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQN 362
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK-NELIEDV 584
E + E + + +TK++ I+E ++ ++ LQ + E T++ NEL +++
Sbjct: 363 EMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKSEEMTLQINELQKEI 418
Query: 585 ELLKKESNSQIKFLREEVEKKRVLCEM 611
E+L++E + L +EV++ ++ E+
Sbjct: 419 EILRQEEKEK-GTLEQEVQELQLKTEL 444
Score = 76.6 bits (180), Expect = 3e-13
Identities = 113/530 (21%), Positives = 241/530 (45%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 169 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 228
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 229 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 288
Query: 215 YDKQMELSS---LEEVITVRDSLCKDLQEKLT-SNELTLAETQQRLEMVKGHHALALEA- 269
+ +E L+ + +++ + L+ +L S+E L++ ++ LE+ H + +E
Sbjct: 289 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIEKL 345
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 346 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 401
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 402 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 461
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 462 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 521
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 522 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 570
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E ++E
Sbjct: 571 SKNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVVEK 626
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E L+ V K EL ++L E + K+ + +I FL EEV+
Sbjct: 627 DTTELMEKLE-VTKREKLELSQRLSDLSEQL----KQKHGEISFLNEEVK 671
Score = 70.5 bits (165), Expect = 2e-11
Identities = 110/485 (22%), Positives = 227/485 (46%), Gaps = 50/485 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF---RQSHNN--ID 156
+ +L+Q + ++ K + C+ K +D + ++ L+ ++E ++F Q N +D
Sbjct: 1679 EQQLLQETEKLMKEKLEVQCQAEKDRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 1738
Query: 157 FNE----IDRKLSKLR--INNTNCHTEHNA-VQGTDAEKVSAMINDMR--SRIIELE-KK 206
+ ++++L K+R ++ EH V + +K+ + + I E + ++
Sbjct: 1739 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 1798
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQRLEMVKGHH 263
E L N + +K + S E++ ++ L +D+QE+ + E + E +Q L +V
Sbjct: 1799 VEQLANHLKEKTDKCS---ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-LVSADT 1854
Query: 264 ALALEANESIRR-EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
+E + E K EL +L+ +L E+ AI K K + NL+ + E L+N
Sbjct: 1855 FQKVEDRKHFGAVEAKPEL-SLEVQLQAERDAIDRKEK-EITNLEEQLEQFREELEN--- 1909
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH--CSQQE 380
K E ++QLH QL I+++E +L+++E ++ K+ + E+ +I+E S Q+
Sbjct: 1910 --KNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLGLAIKESDAMSTQD 1963
Query: 381 KTIQY--LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT---- 434
+ + + Q I+E + +D N Q + L+Q+L + +++ EK I +++T
Sbjct: 1964 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIEC 2021
Query: 435 -LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+ D+ K N E E +LN +EK +E S+ H L+ +L+
Sbjct: 2022 LMSDQECVKR-NREEEIEQLNEVIEKLQQELANIGQKTSMN---AHSLSEEADSLKHQLD 2077
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ + L E E+T KN L T + ++ + L ++ + + ++ K + I E
Sbjct: 2078 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IPE 2136
Query: 554 HNVTL 558
++V +
Sbjct: 2137 NSVNV 2141
Score = 69.3 bits (162), Expect = 4e-11
Identities = 92/403 (22%), Positives = 180/403 (44%), Gaps = 33/403 (8%)
Query: 202 ELEKKCEALDNE-VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
E +KK E + E + +K+ + L I + +L++KLT+ + L E Q+++
Sbjct: 1 EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQI---- 56
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNAS-IES-LK 318
++ N+ I+ K+EL K K + + I +E K H S E+ +
Sbjct: 57 ------VQKNQEIKN-MKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 109
Query: 319 NQMLKEKCEALEQLHSQL--IIKEQEMKAKLEQIEESAS--EKLKICEIQFEERSQSIQE 374
+M +E LEQL ++L + +Q ++ K E I + + E++K E +
Sbjct: 110 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYS 169
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
+ + E I+ + I EL L TN+Q LK+EL + K L + + +EE+
Sbjct: 170 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 229
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE- 493
++++ +++KLN E +K SLS D+ + + ES ELE
Sbjct: 230 SREQIQRARQTIAEQESKLN--------EAHK---SLSTVEDLKAEI-VSASESRKELEL 277
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTL-NNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
+ E +V E+LE E + + + E + + L+ + + + KE I
Sbjct: 278 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI- 336
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
EH + + + N+ +++ ++NE+ + +E ++ E ++ I
Sbjct: 337 EHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI 379
Score = 63.3 bits (147), Expect = 3e-09
Identities = 83/418 (19%), Positives = 188/418 (44%), Gaps = 27/418 (6%)
Query: 198 SRIIELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN-ELTLAETQQ 254
+R+ ELE + + + + E+ +Q E E V L ++ ++ + E+ +
Sbjct: 1645 NRLQELEAEQQQIQEERELLSRQKEAMKAEAG-PVEQQLLQETEKLMKEKLEVQCQAEKD 1703
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLD--EEKQAI---ISKCK--VDQENLK 307
R ++ K AL ++ E + R ++E E +D ++ QA+ + K + +D++ +
Sbjct: 1704 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 1763
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H + + Q L+++ + + + I E + + ++EQ+ EK C
Sbjct: 1764 REHERDVFQQEIQKLEQQLKVVPRFQP---ISEHQTR-EVEQLANHLKEKTDKCSELLLS 1819
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q +Q ++ + I+ LE ++EL+ L ++ +D Q++ + K+ + + +
Sbjct: 1820 KEQ-LQRDIQERNEEIEKLEFRVRELEQALLVS----ADTFQKVEDRKHFGAVEAKPELS 1874
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLR 486
+++ +D + K N + +L E+ ++ KN+ L + +I T RL+
Sbjct: 1875 LEVQLQAERDAIDRKEKEITNLEEQLEQFREE-LENKNEEVQQLHMQLEIQKKESTTRLQ 1933
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
E + E + +D ++ L A + + T ++ L + + KE ++ L + +
Sbjct: 1934 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 1993
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ +I N + E + E R+L T L+ D E +K+ +I+ L E +EK
Sbjct: 1994 QQLKITTDNKVIEE-----KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2046
Score = 54.8 bits (126), Expect = 1e-06
Identities = 101/502 (20%), Positives = 214/502 (42%), Gaps = 44/502 (8%)
Query: 132 NEIAQLQEILKELATKFRQSHNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVS 190
N ++LQ +++L ++ + ++ ++ + +L + TE Q E++
Sbjct: 1533 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLH 1592
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
+EL K +D +K + ++E + D L ++L SN L
Sbjct: 1593 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELL--CASNRLQEL 1650
Query: 251 ETQQRLEMVKGHHALALEANESIRREY-KIELEALKT--KLDEEKQAIISKCKVDQENLK 307
E +Q + ++ L E+++ E +E + L+ KL +EK + + + D+++L+
Sbjct: 1651 EAEQ--QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKDRDDLQ 1708
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
K ++E + + E ++ +++L+ Q+ +A +Q+E+ K + Q +
Sbjct: 1709 -KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR----KFLDEQAID 1763
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST---- 423
R + QQE IQ LEQ++K + ++ +Q +++Q N+LK D+ S
Sbjct: 1764 REH--ERDVFQQE--IQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 1819
Query: 424 ---------EKFNFIEE----IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETS 470
E+ IE+ ++ L+ L+ ++ +++ + +A K + E
Sbjct: 1820 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA-KPELSLEVQ 1878
Query: 471 LSVTRDIV-----HVLTL--RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNT 523
L RD + + L +L + ELE ++VQ L E+ + E TT L
Sbjct: 1879 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 1938
Query: 524 VRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT-IKNEL-I 581
+ + E L +K A++ + ++ I + VE + E T ++ +L I
Sbjct: 1939 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 1998
Query: 582 EDVELLKKESNSQIKFLREEVE 603
+ +E N I+ L ++E
Sbjct: 1999 TTDNKVIEEKNELIRDLETQIE 2020
Score = 54.8 bits (126), Expect = 1e-06
Identities = 92/405 (22%), Positives = 184/405 (45%), Gaps = 42/405 (10%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
+SSL+++IT + L ++ E S++ + + R E++ + LE + ++ E
Sbjct: 2679 ISSLKDLIT-KMQLQREA-EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTE 2736
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL---- 336
L AL T + +++ + + ++ A++E L+ + ++ LH+Q+
Sbjct: 2737 LTALGTT---DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 2793
Query: 337 --IIKEQEM-KAKLEQIEESASEKL-KICEIQFE-----ERSQSIQEHCSQQEKTIQYLE 387
+ +EQE K E +E + +K ++ E+Q E +R+ +QE S ++ + L+
Sbjct: 2794 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 2853
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
E+ + K L+ T LK + +LK EL E F + KT + L+ T+ E
Sbjct: 2854 SELAQTKLELETT------LKAQHKHLK----EL--EAFRLEVKDKTDEVHLLNDTLASE 2901
Query: 448 NEKNK-LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ----LEDQVQML 502
+K++ L A+E KEK K S ++ + L L Q LE Q Q+L
Sbjct: 2902 QKKSRELQWALE---KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 2958
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
+++ +E++ Y L+ E E V +L+S+ +E + ++ L L
Sbjct: 2959 NESQQKIESQRMLYDAQLS---EEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQL 3014
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
Q+ + +L+++++ +E +S+I L E EK ++
Sbjct: 3015 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3059
Score = 54.0 bits (124), Expect = 2e-06
Identities = 101/516 (19%), Positives = 213/516 (41%), Gaps = 47/516 (9%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
D L DV I K +Q+E E+ ++ +LKE N N++ +
Sbjct: 2070 DSLKHQLDVVIAEK----LALEQQVETANEEMTFMKNVLKE---------TNFKMNQLTQ 2116
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEVYDKQMEL 221
+L L+ + + + + + + D ++ E ++L+N+ Y K E
Sbjct: 2117 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2176
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-NESIRREYKIE 280
+ +I + L + L+ +++ +L L + ++++ ++ E + I KI
Sbjct: 2177 NGKGSIINLETRLLQ-LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2235
Query: 281 LEALKTKLDEEKQ--AIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
E + L + Q A+ K Q+N +++N L+E + L S L
Sbjct: 2236 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALT 2293
Query: 338 IKEQEMKAKLEQIEESA---SEKLKICEIQFEERSQSIQE--------HCSQQEKTIQYL 386
++ E+++++ ++ S E+++I E E+ + + E Q+EK +
Sbjct: 2294 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2353
Query: 387 EQEIKELKYTLDLTN-NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
Q+++ LK T +L + N+ S EL L+ E ++ E+ + L++EL+ K N
Sbjct: 2354 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2413
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+ + L+ + + K K S+ D V +S+ + + + + S
Sbjct: 2414 MTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEV-------QESKKACMFEPLPIKLSK 2464
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
+ + T ++ N T + K A + I ++E T I+ IE +Q +
Sbjct: 2465 SIASQTDGTLKISSSNQTPQIL--VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2522
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREE 601
E+ +++ I + E LK+E ++ L+EE
Sbjct: 2523 HAA---EILDMESRHISETETLKREHYVAVQLLKEE 2555
Score = 53.6 bits (123), Expect = 2e-06
Identities = 101/488 (20%), Positives = 217/488 (44%), Gaps = 39/488 (7%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVE---IRNKDQTICEYNKQIEDYKNEIAQLQEILKEL 144
I T K+ + +D+ A+ +E + KD T E +++E K E +L + L +L
Sbjct: 595 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT--ELMEKLEVTKREKLELSQRLSDL 652
Query: 145 ATKFRQSHNNIDF-NEIDRKLSK------LRINNTNCHTEHNAVQGTDA--EKVSAMIND 195
+ + +Q H I F NE + L + LR HN + + +VS++++
Sbjct: 653 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 712
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEKLTSNEL--TLAET 252
+ + + + N+ + ++ ++ ++V ++ ++ QE+L + L E+
Sbjct: 713 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 772
Query: 253 QQRLEMVKGHHALALEAN--ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
R + L E N +S + + ++++EA + L + + + EN K K
Sbjct: 773 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 832
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ---FEE 367
S++ +EK + L+++H ++ Q MK + E +E L I ++Q EE
Sbjct: 833 LCSLKEELIFAQEEKIKELQKIHQ---LELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 888
Query: 368 RSQSIQEHCS-QQEKTIQYLEQEI--KELKYTLD-LTNNQNSDLKQELNNLKNCKDELST 423
S +Q CS E L+ E+ ++ + + D ++ N++ +L+ +++ ++ + T
Sbjct: 889 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 948
Query: 424 EKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
EE L + K + + KL E KE+ +F LS+ + ++
Sbjct: 949 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLE 1005
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ + S+L L+D + T +E ++ EL + ++L ++E ++ EA ++ L+ +
Sbjct: 1006 DIDVNHK-SKLSSLQDLEK--TKLEEQVQ-ELESLISSLQQQLKETEQNYEAEIHCLQKR 1061
Query: 542 AALTKEHT 549
E T
Sbjct: 1062 LQAVSEST 1069
Score = 37.1 bits (82), Expect = 0.22
Identities = 64/339 (18%), Positives = 146/339 (43%), Gaps = 31/339 (9%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDF 157
Q ++++ Q VE+ + E +Q+ K +A+L+ L EL T + H ++
Sbjct: 2818 QSQMLEMQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 2876
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK----CEALDNE 213
E R K + + + + A + + ++ + ++++ E++ E L
Sbjct: 2877 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 2936
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT----LAETQQR-LEM---VKGHHAL 265
+ ++ L ++ + L + Q+K+ S + L+E Q R LE+ ++
Sbjct: 2937 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 2996
Query: 266 ALEANESIRREYKIELEALKTK-LDEEKQAIISK--CKVDQENLKTKHNASIESLKNQML 322
E + ++ RE ++ + + + + + S+ K Q+ L+ KH+ +E L N+
Sbjct: 2997 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELL-NETE 3055
Query: 323 KEKCEALE---------QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
K K ++L+ Q+H + + EQE + ++ K++ + Q EE+ Q +
Sbjct: 3056 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3115
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ + + +Q + QE ++ + + L Q LN
Sbjct: 3116 K-LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN 3153
Score = 36.3 bits (80), Expect = 0.38
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 50/323 (15%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIEDYKNEIAQ-LQEILKELATKFRQSHNNIDF 157
Q LV ++ E+ N+ Q E +Q E K + Q +QE+ +L T+ +
Sbjct: 396 QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL--QLKTELLEKQMKEKE 453
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK 217
N++ K ++L N+ E ++ D K+ ++ R+I L+ + V++K
Sbjct: 454 NDLQEKFAQLEAENSILKDEKKTLE--DMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEK 510
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM----VKGHHALALEANESI 273
++E+ +EE ++ C L E++ T + ++ E+ ++ +A L+ + +
Sbjct: 511 EIEIL-IEENEDLKQQ-CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 568
Query: 274 RR-------EYKIELEALKTKL-----------------DEEKQAIISKCKVDQ--ENLK 307
EYK +L+AL +L DE+K + ++ + E
Sbjct: 569 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 628
Query: 308 TKHNASIESLK------NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
T+ +E K +Q L + E L+Q H ++ +E+K+ L+Q +E S + +
Sbjct: 629 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS-LKQEKEQVSLRCREL 687
Query: 362 EIQF-EERSQSIQEHCSQQEKTI 383
EI R++++Q C Q ++
Sbjct: 688 EIIINHNRAENVQS-CDTQVSSL 709
Score = 35.5 bits (78), Expect = 0.67
Identities = 78/363 (21%), Positives = 155/363 (42%), Gaps = 46/363 (12%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQ----IEDYKNEIAQLQEILKELATKFRQS 151
+ ++L + V A+D+E+ + I + +Q E + +I LQ+I++E S
Sbjct: 2186 ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2245
Query: 152 HNNIDFNEIDRKLSKLRINNT-NCHTEHNAVQGTDA---EKVSAMINDMRSRIIELEKKC 207
I + + N T + E +Q + +++ + I+ + RI ELE +
Sbjct: 2246 Q--IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQV 2303
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + ++ ++ E+ + ++ +LQ+ L N E +QR
Sbjct: 2304 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN-----EKKQR------------ 2346
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
E ++ ++E LKT + S + E L+ + A+ L + KEK E
Sbjct: 2347 ---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAE 2401
Query: 328 ALEQLHSQLIIKEQEM---KAKLEQIEE---SASEKLKICEIQFEERSQSIQEHCSQQEK 381
L++ +L++KE M + L Q+ + A EKL I E + E Q ++ C +
Sbjct: 2402 KLQE---ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2458
Query: 382 TIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKTLKDEL 439
I+ + + TL + ++NQ + + ++ N + E S+E+ + EI + E
Sbjct: 2459 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE---VTEIISQFTEK 2515
Query: 440 IEK 442
IEK
Sbjct: 2516 IEK 2518
>AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein.
Length = 1642
Score = 90.6 bits (215), Expect = 2e-17
Identities = 141/643 (21%), Positives = 276/643 (42%), Gaps = 43/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 355 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 413
Query: 149 ----RQSHNNIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+++H + F + R + + E + + G ++ + +R + +
Sbjct: 414 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQ 471
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH 262
+E+ E+ + S+ ITV + K + + + L +T + E +K
Sbjct: 472 MEEMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 527
Query: 263 HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQM 321
L LE +++R+ + +E L ++ ++A + + + + N K +++E LK ++
Sbjct: 528 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 587
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
+ E+ ++L + + K KLE +E+ EK + + E + ++ +Q
Sbjct: 588 VSAS-ESRKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQ--- 640
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSD-LKQELN-NLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ E+E+ +LK L++ + N + LK L + K D L E IE ++ KD L
Sbjct: 641 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 700
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
I K E +KL + + K++ E +L + ++ + + LR+ + E LE +V
Sbjct: 701 ITKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEV 757
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTL 558
Q L E+LE ++ +N L + + L + K+ + K HT + E +
Sbjct: 758 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 817
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXX 618
++S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 818 LDSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEV 871
Query: 619 XXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQ 678
L + DL +++N++ +L EL L R TV +
Sbjct: 872 NYQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELHLQRIN----PTTVKMK 925
Query: 679 SSIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
SS+ D+ K + LE + K + L + L+V K +S
Sbjct: 926 SSVFDEDKTFVAETLEMGEVXEKDTTELMEKLEVTKREKLELS 968
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/521 (20%), Positives = 232/521 (44%), Gaps = 37/521 (7%)
Query: 99 ILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
+L + + ++ +D + +Y K+ ED+ +I+ LQE +K + + N +
Sbjct: 275 LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKE 334
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA--MINDMRSRIIELEKKCEALDNEVYD 216
EI K + + NT E + +A ++ +++ +I++ ++ + + E+ +
Sbjct: 335 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 394
Query: 217 -KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
KQ E S EE+ + ++ ++LQ++ + + QR+E E +R
Sbjct: 395 SKQKERQSSEEIKQLMGTV-EELQKRNHKDSQFETDIVQRMEQETQRKL------EQLRA 447
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E E ++ + KQ +I + E +KT+H +E+ E
Sbjct: 448 ELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY--SNITVNEDQIKL 502
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+ + E+ KL Q S EKLK EE ++E C+ Q + LE ++EL +
Sbjct: 503 MNVAINELNIKL-QDTNSQKEKLK------EELGLILEEKCALQRQ----LEDLVEELSF 551
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
+ + + ++ + L LST + + EI + + E + +E E +
Sbjct: 552 SREQIQRARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKI 610
Query: 456 AVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLEN 511
+E KEKN ++ ++ ++ + T L + EL +L++ +++ + +++ +N
Sbjct: 611 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 670
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
YK ++ E + E + + +TK++ I+E ++ ++ LQ +
Sbjct: 671 LGIHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKS 726
Query: 572 ELGTIK-NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E T++ NEL +++E+L++E + L +EV++ ++ E+
Sbjct: 727 EEMTLQINELQKEIEILRQEEKEK-GTLEQEVQELQLKTEL 766
Score = 73.7 bits (173), Expect = 2e-12
Identities = 110/494 (22%), Positives = 216/494 (43%), Gaps = 35/494 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTN 173
R KD+T+ E+ + E + Q Q+ L+ T +H++ + + K L
Sbjct: 231 REKDETMREFLELTEQSQKLQIQFQQ-LQASETLRNSTHSSTAADLLQAKQQILT----- 284
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDS 233
H + Q E D +I L++K + + E DK++E S+ EE I +++
Sbjct: 285 -HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEE-IQEKET 341
Query: 234 LCKDLQEKLTSNELTLAETQQRL----EMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++L K+ E E + +L +++ ++ N+ I+ K+EL K K
Sbjct: 342 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN-MKLELTNSKQKER 400
Query: 290 EEKQAIISKCKVDQENLKTKHNAS-IES-LKNQMLKEKCEALEQLHSQL--IIKEQEMKA 345
+ + I +E K H S E+ + +M +E LEQL ++L + +Q ++
Sbjct: 401 QSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM 460
Query: 346 KLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
K E I + + E++K E + + + E I+ + I EL L TN+Q
Sbjct: 461 KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 520
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL + K L + + +EE+ ++++ +++KLN E
Sbjct: 521 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN--------E 572
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTL-N 521
+K SLS D+ + + ES ELE + E +V E+LE E + +
Sbjct: 573 AHK---SLSTVEDLKAEI-VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 628
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ E + + L+ + + + KE I EH + + + N+ +++ ++NE+
Sbjct: 629 SQEAELERLRTQLLFSHEEELSKLKEDLEI-EHRINIEKLKDNLGIHYKQQIDGLQNEMS 687
Query: 582 EDVELLKKESNSQI 595
+ +E ++ E ++ I
Sbjct: 688 QKIETMQFEKDNLI 701
Score = 73.3 bits (172), Expect = 3e-12
Identities = 113/530 (21%), Positives = 238/530 (44%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 491 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 550
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 551 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 610
Query: 215 YDKQMELSS---LEEVITVRDSLCKDLQEKLT-SNELTLAETQQRLEMVKGHHALALEA- 269
+ +E L+ + +++ + L+ +L S+E L++ ++ LE+ H + +E
Sbjct: 611 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIEKL 667
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 668 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 723
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 724 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 783
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 784 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 843
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 844 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 892
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E + E
Sbjct: 893 SKNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVXEK 948
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E L+ V K EL ++L E + K +I FL EEV+
Sbjct: 949 DTTELMEKLE-VTKREKLELSQRLSDLSEQL----KPKPGEISFLNEEVK 993
Score = 46.8 bits (106), Expect = 3e-04
Identities = 99/488 (20%), Positives = 214/488 (43%), Gaps = 39/488 (7%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVE---IRNKDQTICEYNKQIEDYKNEIAQLQEILKEL 144
I T K+ + +D+ A+ +E + KD T E +++E K E +L + L +L
Sbjct: 917 INPTTVKMKSSVFDEDKTFVAETLEMGEVXEKDTT--ELMEKLEVTKREKLELSQRLSDL 974
Query: 145 ATKFRQSHNNIDF-NEIDRKLS------KLRINNTNCHTEHNAVQGTDA--EKVSAMIND 195
+ + + I F NE + L LR HN + + +VS++++
Sbjct: 975 SEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRELEIIINHNRAENVXSCDTQVSSLLDG 1034
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEKLTSNEL--TLAET 252
+ + + + N+ + ++ ++ ++V ++ ++ QE+L + L E+
Sbjct: 1035 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1094
Query: 253 QQRLEMVKGHHALALEAN--ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
R + L E N +S + + ++++EA + L + + + EN K K
Sbjct: 1095 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1154
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ---FEE 367
S++ +EK + L+++H ++ Q MK + E +E L I ++Q EE
Sbjct: 1155 LCSLKEELIFAQEEKIKELQKIHQ---LELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1210
Query: 368 RSQSIQEHCS-QQEKTIQYLEQEI--KELKYTLD-LTNNQNSDLKQELNNLKNCKDELST 423
S +Q CS E L+ E+ ++ + + D ++ N++ +L+ +++ ++ + T
Sbjct: 1211 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1270
Query: 424 EKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
EE L + K + + KL E KE+ +F LS+ + ++
Sbjct: 1271 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLE 1327
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ + S+L L+D + T +E ++ EL + ++L ++E ++ EA ++ L+ +
Sbjct: 1328 DIDVNHK-SKLSSLQDLEK--TKLEEQVQ-ELESLISSLXQQLKETEQNYEAEIHCLQKR 1383
Query: 542 AALTKEHT 549
E T
Sbjct: 1384 LQAVSEST 1391
>AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein.
Length = 1620
Score = 90.6 bits (215), Expect = 2e-17
Identities = 141/643 (21%), Positives = 276/643 (42%), Gaps = 43/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 324 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 382
Query: 149 ----RQSHNNIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+++H + F + R + + E + + G ++ + +R + +
Sbjct: 383 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQ 440
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH 262
+E+ E+ + S+ ITV + K + + + L +T + E +K
Sbjct: 441 MEEMKTRHKGEMENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 496
Query: 263 HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQM 321
L LE +++R+ + +E L ++ ++A + + + + N K +++E LK ++
Sbjct: 497 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 556
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
+ E+ ++L + + K KLE +E+ EK + + E + ++ +Q
Sbjct: 557 VSAS-ESRKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQ--- 609
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSD-LKQELN-NLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ E+E+ +LK L++ + N + LK L + K D L E IE ++ KD L
Sbjct: 610 LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL 669
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
I K E +KL + + K++ E +L + ++ + + LR+ + E LE +V
Sbjct: 670 ITKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEV 726
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTL 558
Q L E+LE ++ +N L + + L + K+ + K HT + E +
Sbjct: 727 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 786
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXX 618
++S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 787 LDSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEV 840
Query: 619 XXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQ 678
L + DL +++N++ +L EL L R TV +
Sbjct: 841 NYQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELHLQRIN----PTTVKMK 894
Query: 679 SSIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
SS+ D+ K + LE + K + L + L+V K +S
Sbjct: 895 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS 937
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/521 (20%), Positives = 232/521 (44%), Gaps = 37/521 (7%)
Query: 99 ILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
+L + + ++ +D + +Y K+ ED+ +I+ LQE +K + + N +
Sbjct: 244 LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKE 303
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA--MINDMRSRIIELEKKCEALDNEVYD 216
EI K + + NT E + +A ++ +++ +I++ ++ + + E+ +
Sbjct: 304 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 363
Query: 217 -KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
KQ E S EE+ + ++ ++LQ++ + + QR+E E +R
Sbjct: 364 SKQKERQSSEEIKQLMGTV-EELQKRNHKDSQFETDIVQRMEQETQRKL------EQLRA 416
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E E ++ + KQ +I + E +KT+H +E+ E
Sbjct: 417 ELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY--SNITVNEDQIKL 471
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+ + E+ KL Q S EKLK EE ++E C+ Q + LE ++EL +
Sbjct: 472 MNVAINELNIKL-QDTNSQKEKLK------EELGLILEEKCALQRQ----LEDLVEELSF 520
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
+ + + ++ + L LST + + EI + + E + +E E +
Sbjct: 521 SREQIQRARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKI 579
Query: 456 AVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLEN 511
+E KEKN ++ ++ ++ + T L + EL +L++ +++ + +++ +N
Sbjct: 580 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN 639
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
YK ++ E + E + + +TK++ I+E ++ ++ LQ +
Sbjct: 640 LGIHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKS 695
Query: 572 ELGTIK-NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E T++ NEL +++E+L++E + L +EV++ ++ E+
Sbjct: 696 EEMTLQINELQKEIEILRQEEKEK-GTLEQEVQELQLKTEL 735
Score = 76.6 bits (180), Expect = 3e-13
Identities = 113/530 (21%), Positives = 241/530 (45%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 460 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 519
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 520 FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 579
Query: 215 YDKQMELSS---LEEVITVRDSLCKDLQEKLT-SNELTLAETQQRLEMVKGHHALALEA- 269
+ +E L+ + +++ + L+ +L S+E L++ ++ LE+ H + +E
Sbjct: 580 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIEKL 636
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 637 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 692
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 693 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 752
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 753 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 812
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 813 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 861
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E ++E
Sbjct: 862 SKNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVVEK 917
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E L+ V K EL ++L E + K+ + +I FL EEV+
Sbjct: 918 DTTELMEKLE-VTKREKLELSQRLSDLSEQL----KQKHGEISFLNEEVK 962
Score = 73.7 bits (173), Expect = 2e-12
Identities = 110/494 (22%), Positives = 216/494 (43%), Gaps = 35/494 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTN 173
R KD+T+ E+ + E + Q Q+ L+ T +H++ + + K L
Sbjct: 200 REKDETMREFLELTEQSQKLQIQFQQ-LQASETLRNSTHSSTAADLLQAKQQILT----- 253
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDS 233
H + Q E D +I L++K + + E DK++E S+ EE I +++
Sbjct: 254 -HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEE-IQEKET 310
Query: 234 LCKDLQEKLTSNELTLAETQQRL----EMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++L K+ E E + +L +++ ++ N+ I+ K+EL K K
Sbjct: 311 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN-MKLELTNSKQKER 369
Query: 290 EEKQAIISKCKVDQENLKTKHNAS-IES-LKNQMLKEKCEALEQLHSQL--IIKEQEMKA 345
+ + I +E K H S E+ + +M +E LEQL ++L + +Q ++
Sbjct: 370 QSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM 429
Query: 346 KLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
K E I + + E++K E + + + E I+ + I EL L TN+Q
Sbjct: 430 KQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 489
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL + K L + + +EE+ ++++ +++KLN E
Sbjct: 490 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN--------E 541
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTL-N 521
+K SLS D+ + + ES ELE + E +V E+LE E + +
Sbjct: 542 AHK---SLSTVEDLKAEI-VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 597
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ E + + L+ + + + KE I EH + + + N+ +++ ++NE+
Sbjct: 598 SQEAELERLRTQLLFSHEEELSKLKEDLEI-EHRINIEKLKDNLGIHYKQQIDGLQNEMS 656
Query: 582 EDVELLKKESNSQI 595
+ +E ++ E ++ I
Sbjct: 657 QKIETMQFEKDNLI 670
Score = 53.6 bits (123), Expect = 2e-06
Identities = 101/488 (20%), Positives = 217/488 (44%), Gaps = 39/488 (7%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVE---IRNKDQTICEYNKQIEDYKNEIAQLQEILKEL 144
I T K+ + +D+ A+ +E + KD T E +++E K E +L + L +L
Sbjct: 886 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT--ELMEKLEVTKREKLELSQRLSDL 943
Query: 145 ATKFRQSHNNIDF-NEIDRKLSK------LRINNTNCHTEHNAVQGTDA--EKVSAMIND 195
+ + +Q H I F NE + L + LR HN + + +VS++++
Sbjct: 944 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1003
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEKLTSNEL--TLAET 252
+ + + + N+ + ++ ++ ++V ++ ++ QE+L + L E+
Sbjct: 1004 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1063
Query: 253 QQRLEMVKGHHALALEAN--ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
R + L E N +S + + ++++EA + L + + + EN K K
Sbjct: 1064 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1123
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ---FEE 367
S++ +EK + L+++H ++ Q MK + E +E L I ++Q EE
Sbjct: 1124 LCSLKEELIFAQEEKIKELQKIHQ---LELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1179
Query: 368 RSQSIQEHCS-QQEKTIQYLEQEI--KELKYTLD-LTNNQNSDLKQELNNLKNCKDELST 423
S +Q CS E L+ E+ ++ + + D ++ N++ +L+ +++ ++ + T
Sbjct: 1180 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1239
Query: 424 EKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
EE L + K + + KL E KE+ +F LS+ + ++
Sbjct: 1240 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLE 1296
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ + S+L L+D + T +E ++ EL + ++L ++E ++ EA ++ L+ +
Sbjct: 1297 DIDVNHK-SKLSSLQDLEK--TKLEEQVQ-ELESLISSLQQQLKETEQNYEAEIHCLQKR 1352
Query: 542 AALTKEHT 549
E T
Sbjct: 1353 LQAVSEST 1360
Score = 36.3 bits (80), Expect = 0.38
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 50/323 (15%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIEDYKNEIAQ-LQEILKELATKFRQSHNNIDF 157
Q LV ++ E+ N+ Q E +Q E K + Q +QE+ +L T+ +
Sbjct: 687 QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL--QLKTELLEKQMKEKE 744
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK 217
N++ K ++L N+ E ++ D K+ ++ R+I L+ + V++K
Sbjct: 745 NDLQEKFAQLEAENSILKDEKKTLE--DMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEK 801
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM----VKGHHALALEANESI 273
++E+ +EE ++ C L E++ T + ++ E+ ++ +A L+ + +
Sbjct: 802 EIEIL-IEENEDLKQQ-CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 859
Query: 274 RR-------EYKIELEALKTKL-----------------DEEKQAIISKCKVDQ--ENLK 307
EYK +L+AL +L DE+K + ++ + E
Sbjct: 860 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 919
Query: 308 TKHNASIESLK------NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
T+ +E K +Q L + E L+Q H ++ +E+K+ L+Q +E S + +
Sbjct: 920 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS-LKQEKEQVSLRCREL 978
Query: 362 EIQF-EERSQSIQEHCSQQEKTI 383
EI R++++Q C Q ++
Sbjct: 979 EIIINHNRAENVQS-CDTQVSSL 1000
>U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein.
Length = 2083
Score = 89.4 bits (212), Expect = 4e-17
Identities = 133/660 (20%), Positives = 294/660 (44%), Gaps = 72/660 (10%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ-L 137
K +A ++K L+ + + +L D +I+ ++T E ++ + + Q +
Sbjct: 262 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 321
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+++K+ + + + E+ RK +L T Q E++ + +
Sbjct: 322 VDVMKKSSEEQIAKLQKLHEKELARKEQEL---TKKLQTREREFQ----EQMKVALEKSQ 374
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
S +++ ++ E ++ + ++EL + ++T ++ +DLQ++ + + E + LE
Sbjct: 375 SEYLKISQEKEQQESLALE-ELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLE 432
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA----S 313
+L+ NE+ ++ + LEA K K ++E ++ K K + E+LK + +A
Sbjct: 433 K-------SLQENENQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWAEE 485
Query: 314 IESLKNQ------MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
++ LK Q L+EKCE ++ + L KE +A +E++ E EKL + + + E
Sbjct: 486 LQVLKQQYQTEMEKLREKCE--QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVNQTELES 543
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
S + E + K LE+E+ LK D T+ +L+ +++ KN + + +
Sbjct: 544 LSSELSEVLKARHK----LEEELSVLK---DQTDKMKQELEAKMDEQKNHHQQ---QVDS 593
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
I+E + + EK + K+++N +E +KE++K L + V L ++
Sbjct: 594 IIKE-HEVSIQRTEKAL-----KDQIN-QLELLLKERDK---HLKEHQAHVENLEADIKR 643
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S+ EL+Q ++ + S + + Y+ L ++ + + + + K A + +
Sbjct: 644 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 703
Query: 548 H----TRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
T + H + + + +Q +EK+ +E+ + V+ L + S+++ +E E
Sbjct: 704 KKDVCTELDAHKIQVQDLMQQLEKQ--------NSEMEQKVKSLTQVYESKLEDGNKEQE 755
Query: 604 K-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS 662
+ K++L E +L + +A + NE Y ++
Sbjct: 756 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK---KME 812
Query: 663 LLRQENEELTMTVAKQSSIID---KLKKDLEQS--QYTPKSPSVLRKSLKVGKENMQTIS 717
++Q+ +E+ T+ K+ ++D KLKK+LE + + + K K L++ + N IS
Sbjct: 813 KVKQKAKEMQETLKKK--LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 870
Score = 87.0 bits (206), Expect = 2e-16
Identities = 122/544 (22%), Positives = 255/544 (46%), Gaps = 51/544 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK---ELATKFRQSH 152
K K+ ++ D E ++ + + NK +ED E +L E L ++ K ++
Sbjct: 1023 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1082
Query: 153 NNIDFNE-IDRKLSKLR-INNTNCHTEHNAVQGTDAEKV-SAMINDMRSRIIELEKKCEA 209
NE I+ SK I + H +H + +A + + ++++ +++ +L ++
Sbjct: 1083 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1142
Query: 210 LD-------NEVYDKQMELSSL----EEVITVRDSLCKDL-QEKLTSNELTLAETQQRLE 257
L+ +++ +K+ ++ S+ E ++T +++L K+ ++ ++E TQ + E
Sbjct: 1143 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1202
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
+ + +A+ L E +E K+E+ +L +L + + + + ++ A+I SL
Sbjct: 1203 LSENINAVTLMKEEL--KEKKVEISSLSKQLTDLNVQLQNSISLSEKE------AAISSL 1254
Query: 318 KNQMLKEKCEALEQ---LHSQLIIKEQEMKAKLEQIEE---SASEKLKICEIQFEERSQS 371
+ Q +EKCE L+Q L ++ +E + LEQ+++ SE K + +F + +
Sbjct: 1255 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1314
Query: 372 IQEHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCKDELSTE 424
++E Q E K +++I LK LD N + LK E+ + ++ + L TE
Sbjct: 1315 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1374
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
+ I L+D + +KTI E+ L N +K I+ K + L +++
Sbjct: 1375 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ-KLQHFQELGEEKDN 1433
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK-A 542
R++E++ ++ LE+QV + + E + EL +N +V+ +E +AL + L+S+ A
Sbjct: 1434 RVKEAEEKILTLENQVYSMKAELETKKKEL----EHVNLSVKSKEEELKALEDRLESESA 1489
Query: 543 ALTKEHTRIMEHNVTLIES---LQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
A E R E + I+ Q EKE + GT + + ++ +E ++ L
Sbjct: 1490 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH--LSELNTKLQEREREVHILE 1547
Query: 600 EEVE 603
E+++
Sbjct: 1548 EKLK 1551
Score = 69.3 bits (162), Expect = 4e-11
Identities = 125/610 (20%), Positives = 255/610 (41%), Gaps = 55/610 (9%)
Query: 119 TICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINNTNCHT 176
T+ E Q+E E + E + L + Q + D E++ SK+ +N T
Sbjct: 1314 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1373
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-------LSSLEEVIT 229
E + ++ + + + + IE+E E L N K +E L +E+
Sbjct: 1374 ELKS----QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1429
Query: 230 VRDSLCKDLQEKLTSNELTLAETQQRLEMVKG---HHALALEANES--------IRREYK 278
+D+ K+ +EK+ + E + + LE K H L++++ E + E
Sbjct: 1430 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1489
Query: 279 IELEALKTKLDEE----KQAIISKCKVDQENLKTKHNASIESLKNQM---------LKEK 325
+L LK K +++ K+ ++S+ + +E K + + L ++ L+EK
Sbjct: 1490 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1549
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+++E S+ +I + K E+ ++ + +EE+ +Q + +++EK +Q
Sbjct: 1550 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR 1609
Query: 386 LEQEIKE-LKYTLDL-TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ QE +E + ++ Q +K E K +D+ E K K LI
Sbjct: 1610 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQ 1669
Query: 444 INYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLRLRESDSELEQLED----Q 498
+ E E K N+ ++ ++ + + +L +L +++E DS L + ++ +
Sbjct: 1670 -HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE 1728
Query: 499 VQMLTSAKEVLEN-ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
++ LTS E L+ + +N + E E K + ++++ K E +HN
Sbjct: 1729 MEELTSKYEKLQALQQMDGRNKPTELLEENTEEK-SKSHLVQPKLLSNME----AQHN-D 1782
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
L L E+E ++LG L +D+ +L+KE +++ L++E +++R ++
Sbjct: 1783 LEFKLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQED 1840
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
+ L+ + L++ E E E + VE LL EE + K
Sbjct: 1841 LELKHNSTLKQLMREFNTQLAQKEQELE-MTIKETINKAQEVEAELLESHQEETNQLLKK 1899
Query: 678 QSSIIDKLKK 687
+ D LK+
Sbjct: 1900 IAEKDDDLKR 1909
Score = 68.9 bits (161), Expect = 6e-11
Identities = 102/564 (18%), Positives = 239/564 (42%), Gaps = 49/564 (8%)
Query: 80 ITKAPNSSIKKTLTCPKNKILPQ-DELVQAQDVEIRNKDQTICEYNKQI-------EDYK 131
+T+ + ++ + K+ Q +EL + +++++ K+Q + E ++I E+
Sbjct: 887 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 946
Query: 132 NEIAQLQE-------ILKELATKFRQSHNNI-----DFNEIDRKLSKLRINNTNCHTEHN 179
EI L+E L EL + +Q ++ D ++ L KL ++ E+
Sbjct: 947 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1006
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
+Q E + + + + ++ EL K + D E + + + + K L
Sbjct: 1007 FLQEQLVE-LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLS 1065
Query: 240 EKLTSN-ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
E+L ++ +T+ LE K + + + ++++ + + + + K+A++ K
Sbjct: 1066 EELAIQLDICCKKTEALLE-AKTNELINISSSKT--NAILSRISHCQHRTTKVKEALLIK 1122
Query: 299 -CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQI--EESAS 355
C V + + + ++ N ++ LE+ +Q+ + MKA +E + E+ A
Sbjct: 1123 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI----KSMKADIESLVTEKEAL 1178
Query: 356 EKLKICEIQFEERSQS----IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL 411
+K + Q +S +++ S+ + +++E+KE K + + Q +DL +L
Sbjct: 1179 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1238
Query: 412 NN---LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKF- 467
N L + +S+ + + EE L D++ + + + + A+E+ NKF
Sbjct: 1239 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1298
Query: 468 ------ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
++ + ++ V L ++L E + ++Q+ +L + K +
Sbjct: 1299 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1358
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ + ++ + L LKS+ A E + IESL V K ++ EL+
Sbjct: 1359 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1418
Query: 582 EDV---ELLKKESNSQIKFLREEV 602
+ + + L +E ++++K E++
Sbjct: 1419 QKLQHFQELGEEKDNRVKEAEEKI 1442
Score = 60.5 bits (140), Expect = 2e-08
Identities = 106/507 (20%), Positives = 219/507 (43%), Gaps = 51/507 (10%)
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
E +T+ ++ E ++ ++ +L +R E +++ +A K L EE A + +
Sbjct: 14 ELVTAYQMLQREKKKLQGILSQSQDKSLRKIAELREELQMDQQA-KKHLQEEFDASLEEK 72
Query: 300 KVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQI-EESAS 355
L+T+ + + L+N M + + L QL Q + KE+ ++ E + E+ AS
Sbjct: 73 DQHISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGAS 132
Query: 356 --------EKLKICEIQFEERSQSIQEH---C----SQQEKTIQYLEQEIKELKYTLDLT 400
+++K E + ++IQ H C S++E + L++ ++EL+ DL
Sbjct: 133 VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLH 192
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLA 456
+ + L +L + KN ++L +K I E K E + E+ + ++
Sbjct: 193 MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ 252
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQML--TSAKE--VLEN 511
E+ ++K K E + + + E+ +L+ ++++Q++ + TS +E L+
Sbjct: 253 GEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 312
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
EL+ K + + +++ E + A + L K KE L + LQ E+E
Sbjct: 313 ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ--------ELTKKLQTREREFQE 364
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVE--KKRVLCEM-XXXXXXXXXXXXXXSRV 628
++ + + + +E Q EE+E KK +L E +R+
Sbjct: 365 QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRI 424
Query: 629 LLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR-QENEELTMTVAKQSSIIDKLKK 687
L +++ + S ENEN+ L V L + + N+E+T+ V K + ++ LK
Sbjct: 425 LELESSLEKSLQENENQ--------SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 476
Query: 688 DLEQSQYTPKSPSVLRKSLKVGKENMQ 714
+Q + VL++ + E ++
Sbjct: 477 --QQDALWAEELQVLKQQYQTEMEKLR 501
Score = 56.8 bits (131), Expect = 3e-07
Identities = 94/505 (18%), Positives = 209/505 (41%), Gaps = 33/505 (6%)
Query: 11 LVAQKNQKKTNVHKKLDSESTKINTKTSSSLCKSR--SNTLNSIRPVDGXXXXXXXXXXX 68
L++Q +K+ K +S +++NTK + L S+
Sbjct: 1510 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1569
Query: 69 XLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIE 128
+ + + ++ ++ + + +++L+Q E K++T+ + +
Sbjct: 1570 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE---KEETVSSHFEMRC 1626
Query: 129 DYKNEIAQLQEI-LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
Y+ + +L+ K+ + H + E ++K S + + N +Q +
Sbjct: 1627 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK--Q 1684
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYD------KQMELSSLE-EVITVRDSLCKDLQE 240
+ + +D++ + E E C+ L+ ++ + +Q E+ +E E +T + + LQ+
Sbjct: 1685 NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ 1744
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI---IS 297
N+ T + E K H + + ++ ++ +LE + EKQ + I
Sbjct: 1745 MDGRNKPTELLEENTEEKSKSH-LVQPKLLSNMEAQHN-DLEFKLAGAEREKQKLGKEIV 1802
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ + D L+ +H +E LK + +E+ E ++Q L +K + L+Q+ + +
Sbjct: 1803 RLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN---STLKQLMREFNTQ 1859
Query: 358 LKICEIQFEERSQSIQEHCSQ-QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
L E +E +I+E ++ QE + LE +E L ++ DLK+ +
Sbjct: 1860 LAQKE---QELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 1916
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEK-TINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
D E + +++T +EL +K E E+N N V I E +T L+
Sbjct: 1917 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV--TIME---LQTQLAQKT 1971
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQ 500
++ L+ +E ++ LED+++
Sbjct: 1972 TLISDSKLKEQEFREQIHNLEDRLK 1996
>AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and
Golgi-localized PKN-associated protein (CG-NAP) protein.
Length = 3899
Score = 89.4 bits (212), Expect = 4e-17
Identities = 142/642 (22%), Positives = 281/642 (43%), Gaps = 41/642 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKEL--AT 146
KKTL K+K+ D+L+ +I K+Q I ++ + K + Q E +K+L
Sbjct: 343 KKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 401
Query: 147 KFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII--ELE 204
+ Q N+ D ++ + + + T E ++ E I M+ +I +
Sbjct: 402 EELQKRNHKD-SQFETDIVQRMEQETQRKLEQ--LRAELDEMYGQQIVQMKQELIRQHMA 458
Query: 205 KKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA 264
+ E + + L S ITV + K + + + L +T + E +K
Sbjct: 459 QMEEIKTRHKGEMENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517
Query: 265 LALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQMLK 323
L LE +++R+ + +E L + ++A + + + + N K +++E LK +++
Sbjct: 518 LILEEKCALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL-KICEIQFEERSQSIQEHCSQQEKT 382
E+ ++L + + K KLE +E+ + L ++ E Q E + + E+
Sbjct: 578 AS-ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEE 636
Query: 383 IQYLEQEIK-ELKYTLD-LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI 440
+ L+++++ E + +++ L +N KQ+++ L+N E+S + IE ++ KD LI
Sbjct: 637 LSKLKEDLEIEHRISIEKLKDNLGIHYKQQIDGLQN---EMSQK----IETMQFEKDNLI 689
Query: 441 EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
K E +KL + + K++ E +L + ++ + + LR+ + E LE +VQ
Sbjct: 690 TKQNQLILEISKLKDLQQSLVNSKSE-EMTLQI-NELQKEIEI-LRQEEKEKGTLEQEVQ 746
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI-MEHNVTLI 559
L E+LE ++ +N L + + L + K+ + K HT + E + +
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXX 619
+S+++ K++ E LIE+ E LK+ Q L EE+EK+R
Sbjct: 807 DSIKSKSKDSVWEKEI--EILIEENEDLKQ----QCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 620 XXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQS 679
L + DL +++N++ +L EL+L R TV +S
Sbjct: 861 YQELQEEYACLLKVKDDLE--DSKNKQELEYKSKLKALNEELNLQRIN----PTTVKMKS 914
Query: 680 SIIDKLK----KDLEQSQYTPKSPSVLRKSLKVGKENMQTIS 717
S+ D+ K + LE + K + L ++L+V K +S
Sbjct: 915 SVFDEDKTFVAETLEMGEVVEKDTTELMENLEVTKREKLELS 956
Score = 84.2 bits (199), Expect = 1e-15
Identities = 106/521 (20%), Positives = 231/521 (44%), Gaps = 37/521 (7%)
Query: 99 ILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
+L + + ++ +D + +Y K+ ED+ +I+ LQE +K + + N +
Sbjct: 263 LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKE 322
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA--MINDMRSRIIELEKKCEALDNEVYD 216
EI K + + NT E + +A ++ +++ +I++ ++ + + E+ +
Sbjct: 323 EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTN 382
Query: 217 -KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
KQ E S EE+ + ++ ++LQ++ + + QR+E E +R
Sbjct: 383 SKQKERQSSEEIKQLMGTV-EELQKRNHKDSQFETDIVQRMEQETQRKL------EQLRA 435
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E E ++ + KQ +I + E +KT+H +E+ E
Sbjct: 436 ELD---EMYGQQIVQMKQELIRQHMAQMEEIKTRHKGEMENALRSY--SNITVNEDQIKL 490
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+ + E+ KL Q S EKLK EE ++E C+ Q + LE ++EL +
Sbjct: 491 MNVAINELNIKL-QDTNSQKEKLK------EELGLILEEKCALQRQ----LEDLVEELSF 539
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
+ + ++ + L LST + + EI + + E + +E E +
Sbjct: 540 SRGQIQRARQTIAEQESKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKI 598
Query: 456 AVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLED--QVQMLTSAKEVLEN 511
+E KEKN ++ ++ ++ + T L + EL +L++ +++ S +++ +N
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKLKEDLEIEHRISIEKLKDN 658
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
YK ++ E + E + + +TK++ I+E ++ ++ LQ +
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILE--ISKLKDLQQSLVNSKS 714
Query: 572 ELGTIK-NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E T++ NEL +++E+L++E + L +EV++ ++ E+
Sbjct: 715 EEMTLQINELQKEIEILRQEEKEK-GTLEQEVQELQLKTEL 754
Score = 78.6 bits (185), Expect = 7e-14
Identities = 113/530 (21%), Positives = 241/530 (45%), Gaps = 50/530 (9%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
+ I ++ ++ +V I + + + N Q E K E+ + E L + +
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 157 FN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
F+ +I R + + + H ++ + K + + +EL+ + E + ++
Sbjct: 539 FSRGQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI 598
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAETQQRLEMVKGHHALALEA- 269
+ +E + + +S +L+ + L S+E L++ ++ LE+ H +++E
Sbjct: 599 KLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKLKEDLEI---EHRISIEKL 655
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI----------ESLKN 319
+++ YK +++ L+ ++ ++ I + +++NL TK N I +SL N
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 711
Query: 320 QMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
+E + +L ++ I +E++ K LEQ + K ++ E Q +E+ +QE +
Sbjct: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
Query: 378 QQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKN-CKDELSTEKFN-FIEEIKT 434
Q E L+ E K L+ L + T + L+++K+ KD + ++ IEE +
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
LK + I+ E ++N + A EKN FE + ++ + L++++ +LE
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFA------EKN-FEVNYQELQE-EYACLLKVKD---DLED 880
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+++ ++ +K NE + TV+ K ++ + K+ A T E ++E
Sbjct: 881 SKNKQELEYKSKLKALNEELNLQRINPTTVK----MKSSVFDEDKTFVAETLEMGEVVEK 936
Query: 555 NVT-LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T L+E+L+ V K EL ++L E + K+ + +I FL EEV+
Sbjct: 937 DTTELMENLE-VTKREKLELSQRLSDLSEQL----KQKHGEISFLNEEVK 981
Score = 72.5 bits (170), Expect = 5e-12
Identities = 109/494 (22%), Positives = 216/494 (43%), Gaps = 35/494 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTN 173
R KD+T+ E+ + E + Q Q+ L+ T +H++ + + K L
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQ-LQASETLRNSTHSSTAADLLQAKQQILT----- 272
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDS 233
H + Q E D +I L++K + + E DK++E S+ EE I +++
Sbjct: 273 -HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEE-IQEKET 329
Query: 234 LCKDLQEKLTSNELTLAETQQRL----EMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++L K+ E E + +L +++ ++ N+ I+ K+EL K K
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN-MKLELTNSKQKER 388
Query: 290 EEKQAIISKCKVDQENLKTKHNAS-IES-LKNQMLKEKCEALEQLHSQL--IIKEQEMKA 345
+ + I +E K H S E+ + +M +E LEQL ++L + +Q ++
Sbjct: 389 QSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM 448
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCS--QQEKTIQYLEQEIKELKYTLDLTNNQ 403
K E I + ++ +I E +++ + + E I+ + I EL L TN+Q
Sbjct: 449 KQELIRQHMAQMEEIKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
LK+EL + K L + + +EE+ + ++ +++KLN E
Sbjct: 509 KEKLKEELGLILEEKCALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLN--------E 560
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTL-N 521
+K SLS D+ + + ES ELE + E +V E+LE E + +
Sbjct: 561 AHK---SLSTVEDLKAEI-VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ E + L+ + + + KE I EH +++ + N+ +++ ++NE+
Sbjct: 617 SQEAELERLSTQLLFSHEEELSKLKEDLEI-EHRISIEKLKDNLGIHYKQQIDGLQNEMS 675
Query: 582 EDVELLKKESNSQI 595
+ +E ++ E ++ I
Sbjct: 676 QKIETMQFEKDNLI 689
Score = 70.9 bits (166), Expect = 1e-11
Identities = 112/482 (23%), Positives = 230/482 (47%), Gaps = 52/482 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF---RQSHNN--ID 156
+ +L+Q + ++ K + C+ K +D + ++ L+ ++E ++F Q N +D
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 157 FNE----IDRKLSKLR--INNTNCHTEHNA-VQGTDAEKVSAMINDMR--SRIIELE-KK 206
+ ++++L K+R ++ EH V + +K+ + + I E + ++
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA 266
E L N + +K + S E++ ++ L +D+QE+ + E+ E + R E+V+ AL
Sbjct: 2111 VEQLANHLKEKTDKCS---ELLLSKEQLQRDIQER--NEEIEKLEFRVR-ELVQ---ALL 2161
Query: 267 LEANESIRR-EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
+E + E K EL +L+ +L E+ AI K K + NL+ + E L+N K
Sbjct: 2162 VEDRKHFGAVEAKPEL-SLEVQLQAERDAIDRKEK-EITNLEEQLEQFREELEN-----K 2214
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH--CSQQEKTI 383
E ++QLH QL I+++E +L+++E ++ K+ + E+ +I+E S Q++ +
Sbjct: 2215 NEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLGLAIKESDAMSTQDQHV 2270
Query: 384 QY--LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-----LK 436
+ Q I+E + +D N Q + L+Q+L + +++ EK I +++T +
Sbjct: 2271 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIECLMS 2328
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
D+ K N E E +LN +EK +E S+ H L+ +L+ +
Sbjct: 2329 DQECVKR-NREEEIEQLNEVIEKLQQELANIGQKTSMN---AHSLSEEADSLKHQLDVVI 2384
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+ L E E+T KN L T + ++ + L ++ + + ++ K + I E++V
Sbjct: 2385 AEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IPENSV 2443
Query: 557 TL 558
+
Sbjct: 2444 NV 2445
Score = 57.6 bits (133), Expect = 1e-07
Identities = 82/417 (19%), Positives = 180/417 (43%), Gaps = 33/417 (7%)
Query: 198 SRIIELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN-ELTLAETQQ 254
+R+ ELE + + + + E+ +Q E E V L ++ ++ + E+ +
Sbjct: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAG-PVEQQLLQETEKLMKEKLEVQCQAEKV 2015
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLD--EEKQAI---ISKCK--VDQENLK 307
R ++ K AL ++ E + R ++E E +D ++ QA+ + K + +D++ +
Sbjct: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H + + Q L+++ + + + I E + + ++EQ+ EK C
Sbjct: 2076 REHERDVFQQEIQKLEQQLKVVPRFQP---ISEHQTR-EVEQLANHLKEKTDKCSELLLS 2131
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q +Q ++ + I+ LE ++EL L + + ++ + K ELS E
Sbjct: 2132 KEQ-LQRDIQERNEEIEKLEFRVRELVQALLVEDRKHFGAVE-------AKPELSLEVQ- 2182
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
++ + D ++ N E + + +E +E + L + + T RL+E
Sbjct: 2183 -LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQE 2238
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
+ E + +D ++ L A + + T ++ L + + KE ++ L + ++
Sbjct: 2239 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2298
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+I N + E + E R+L T L+ D E +K+ +I+ L E +EK
Sbjct: 2299 QLKITTDNKVIEE-----KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2350
Score = 54.8 bits (126), Expect = 1e-06
Identities = 101/516 (19%), Positives = 213/516 (41%), Gaps = 47/516 (9%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
D L DV I K +Q+E E+ ++ +LKE N N++ +
Sbjct: 2374 DSLKHQLDVVIAEK----LALEQQVETANEEMTFMKNVLKE---------TNFKMNQLTQ 2420
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEVYDKQMEL 221
+L L+ + + + + + + D ++ E ++L+N+ Y K E
Sbjct: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-NESIRREYKIE 280
+ +I + L + L+ +++ +L L + ++++ ++ E + I KI
Sbjct: 2481 NGKGSIINLETRL-RQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539
Query: 281 LEALKTKLDEEKQ--AIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
E + L + Q A+ K Q+N +++N L+E + L S L
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALT 2597
Query: 338 IKEQEMKAKLEQIEESA---SEKLKICEIQFEERSQSIQE--------HCSQQEKTIQYL 386
++ E+++++ ++ S E+++I E E+ + + E Q+EK +
Sbjct: 2598 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657
Query: 387 EQEIKELKYTLDLTN-NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
Q+++ LK T +L + N+ S EL L+ E ++ E+ + L++EL+ K N
Sbjct: 2658 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2717
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+ + L+ + + K K S+ D V +S+ + + + + S
Sbjct: 2718 MTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEV-------QESKKACMFEPLPIKLSK 2768
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
+ + T ++ N T + K A + I ++E T I+ IE +Q +
Sbjct: 2769 SIASQTDGTLKISSSNQTPQIL--VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2826
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREE 601
E+ +++ I + E LK+E ++ L+EE
Sbjct: 2827 HAA---EILDMESRHISETETLKREHYVAVQLLKEE 2859
Score = 54.4 bits (125), Expect = 1e-06
Identities = 92/405 (22%), Positives = 184/405 (45%), Gaps = 42/405 (10%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
+SSL+++IT + L ++ E S++ + + R E++ + LE + ++ E
Sbjct: 2983 ISSLKDLIT-KMQLQREA-EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTE 3040
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL---- 336
L AL T + +++ + + ++ A++E L + ++ LH+Q+
Sbjct: 3041 LTALGTT---DAVGLLNCLEQRIQEQGVEYQAAMECLHKADRRSLLSEIQALHAQMNGRK 3097
Query: 337 --IIKEQEM-KAKLEQIEESASEKL-KICEIQFE-----ERSQSIQEHCSQQEKTIQYLE 387
+ +EQE K E +E + +K ++ E+Q E +R+ +QE S ++ + L+
Sbjct: 3098 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 3157
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
E+ + K L+ T LK + +LK EL E F + KT + L+ T+ E
Sbjct: 3158 SELAQTKLELETT------LKAQHKHLK----EL--EAFRLEVKDKTDEVHLLNDTLASE 3205
Query: 448 NEKNK-LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ----LEDQVQML 502
++K++ L A+E KEK K S ++ + L L Q LE Q Q+L
Sbjct: 3206 HKKSRELQWALE---KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3262
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
+++ +E++ Y L+ E E V +L+S+ +E + ++ L L
Sbjct: 3263 NESQQKIESQRMLYDAQLS---EEQGRNLELQV-LLQSQKVRIREMSSTLDRERELHAQL 3318
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
Q+ + +L+++++ +E +S+I L E EK ++
Sbjct: 3319 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3363
Score = 54.0 bits (124), Expect = 2e-06
Identities = 94/469 (20%), Positives = 193/469 (41%), Gaps = 29/469 (6%)
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK 217
+E +L ++ T E + E + ++R R+ E + E L E+
Sbjct: 1862 SETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSKA 1920
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY 277
+ + + T+ + ++ + + E L RL+ ++ E E + R+
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 278 KIELEALKTKLDEEKQAIISKC-KVDQENLKTKHNASI--ESLKNQMLKEKCEALEQLHS 334
EA+K + +Q ++ + K+ +E L+ + A + L+ Q+ + + EQ+ S
Sbjct: 1981 ----EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV-S 2035
Query: 335 QLIIKEQEMKAKL---EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
+ I EQE +L Q ++ ++L+ +E++ + ++ IQ LEQ++K
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKD---ELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ ++ +Q +++Q N+LK D EL K +I+ +E+ +
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
Query: 449 EKNKLNLAVEK---AIKEKNKF--ETSLSVTRDIV-----HVLTL--RLRESDSELEQLE 496
L + K A++ K + E L RD + + L +L + ELE
Sbjct: 2156 LVQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKN 2215
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
++VQ L E+ + E TT L + + E L +K A++ + ++
Sbjct: 2216 EEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF 2275
Query: 557 TLIESLQNVEKEAYRELGT-IKNEL-IEDVELLKKESNSQIKFLREEVE 603
I + VE + E T ++ +L I + +E N I+ L ++E
Sbjct: 2276 AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIE 2324
Score = 52.8 bits (121), Expect = 4e-06
Identities = 110/492 (22%), Positives = 212/492 (43%), Gaps = 47/492 (9%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVE---IRNKDQTICEYNKQIEDYKNEIAQLQEILKEL 144
I T K+ + +D+ A+ +E + KD T E + +E K E +L + L +L
Sbjct: 905 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT--ELMENLEVTKREKLELSQRLSDL 962
Query: 145 ATKFRQSHNNIDF-NEIDRKLSK------LRINNTNCHTEHNA---VQGTDAEKVSAM-- 192
+ + +Q H I F NE + L + LR HN VQ D ++ S +
Sbjct: 963 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAEDVQSCDTQESSLLDG 1022
Query: 193 INDMRSRIIE--LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL--T 248
+ M SR E + K ++ E + S E + +S QE+L + L
Sbjct: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK----QEQLILDHLPSV 1078
Query: 249 LAETQQRLEMVKGHHALALEAN--ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
E+ R + L E N +S + + ++++EA + L + + + EN
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENE 1138
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ-- 364
K K S++ +EK + L+++H ++ Q MK + E +E L I ++Q
Sbjct: 1139 KDKALCSLKEELIFAQEEKIKELQKIHQ---LELQTMKTQ-ETGDEGKPLHLLIGKLQKA 1194
Query: 365 -FEERSQSIQEHCS-QQEKTIQYLEQEI--KELKYTLD-LTNNQNSDLKQELNNLKNCKD 419
EE S +Q CS E L+ E+ ++ + + D ++ N++ +L+ +++ ++
Sbjct: 1195 VSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQE 1254
Query: 420 ELSTEKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
+ T EE L + K + + KL E KE+ +F LS+ +
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF---LSIHSQM 1311
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
++ + + S+L L+D + T +E ++ EL + ++L ++E ++ EA ++
Sbjct: 1312 TNLEDIDVNHK-SKLSSLQDLEK--TKLEEQVQ-ELESLISSLQQQLKETEQNYEAEIHC 1367
Query: 538 LKSKAALTKEHT 549
L+ + E T
Sbjct: 1368 LQKRLQAVSEST 1379
Score = 41.1 bits (92), Expect = 0.013
Identities = 55/311 (17%), Positives = 133/311 (42%), Gaps = 15/311 (4%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
+S + +T N++ + E+++ ++ E +Q + E + E + ++ + + L+E
Sbjct: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKF 770
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII---- 201
+ ++ N+I +E L+I+ E + K + + I+
Sbjct: 771 AQL-EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829
Query: 202 -ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+L+++C L+ E+ ++ S E+ V ++ L + L +++ + E+
Sbjct: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY 889
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCK----VDQENLKTKHNASI-- 314
AL +++R ++ + DE+K + + V+++ + N +
Sbjct: 890 KSKLKALNEELNLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMENLEVTK 949
Query: 315 -ESLK-NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
E L+ +Q L + E L+Q H ++ +E+K+ L+Q +E S + + EI
Sbjct: 950 REKLELSQRLSDLSEQLKQKHGEISFLNEEVKS-LKQEKEQVSLRCRELEIIINHNRAED 1008
Query: 373 QEHCSQQEKTI 383
+ C QE ++
Sbjct: 1009 VQSCDTQESSL 1019
Score = 39.9 bits (89), Expect = 0.031
Identities = 74/343 (21%), Positives = 149/343 (43%), Gaps = 39/343 (11%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNID- 156
Q ++++ Q VE+ + E +Q+ K +A+L+ L EL T + H ++
Sbjct: 3122 QSQMLEMQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180
Query: 157 ---FN-EIDRKLSKLRINNTNCHTEHNAVQGTD--AEKVSAMINDMRSRIIE-LEKKCEA 209
F E+ K ++ + N +EH + EK A + R E LE +
Sbjct: 3181 LEAFRLEVKDKTDEVHLLNDTLASEHKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3240
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT----LAETQQR-LEM---VKG 261
L+++ KQ L L ++ + L + Q+K+ S + L+E Q R LE+ ++
Sbjct: 3241 LESQ---KQRNLQ-LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLQS 3296
Query: 262 HHALALEANESIRREYKIELEALKTK-LDEEKQAIISK--CKVDQENLKTKHNASIESLK 318
E + ++ RE ++ + + + + + S+ K Q+ L+ KH+ +E L
Sbjct: 3297 QKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELL- 3355
Query: 319 NQMLKEKCEALE---------QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERS 369
N+ K K ++L+ Q+H + + EQE + ++ K++ + Q EE+
Sbjct: 3356 NETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKR 3415
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
Q + + + + +Q + QE ++ + + L Q LN
Sbjct: 3416 QQVYK-LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN 3457
>Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein.
Length = 2663
Score = 88.6 bits (210), Expect = 7e-17
Identities = 125/587 (21%), Positives = 270/587 (45%), Gaps = 55/587 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNID-----FNEIDRKLSKLRINNTNCHTEHNAVQ 182
E ++E QL+E +KE+ K ++ + E + +++LR+N + TE + +Q
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1511
Query: 183 GTDAEKVSAMINDMRSRIIELEKKCEALD----NEVYDKQMELSSLEEVITVRDSLCKDL 238
+++ A+ + ++++I E+ +K E L+ +EV + EL +E +DS + +
Sbjct: 1512 ----KQLEAINDKLQNKIQEIYEKEEQLNIKQISEVQENVNELKQFKEHRKAKDSALQSI 1567
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+ K+ L E+Q+ +++ + E E R + +++E + +L E + I++K
Sbjct: 1568 ESKMLELTNRLQESQEEIQI------MIKEKEEMKRVQEALQIE--RDQLKENTKEIVAK 1619
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
K QE ++ + N+ ++ CE +E L Q + K LE IE +E +
Sbjct: 1620 MKESQEK---EYQFLKMTAVNETQEKMCE-IEHLKEQF----ETQKLNLENIE---TENI 1668
Query: 359 KICEIQFE--ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK- 415
++ +I E E +S+ + + L+ E +LK L T ++ + ++EL +
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 416 NCKDELST-EKFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIK----EKNKFET 469
+ K+ T +K I KT + ++K + + N+ K +L +++ ++ + +
Sbjct: 1729 HLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQE 1788
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
++ R IV T +L +LE ++Q + E++L T K +N T ++ E
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848
Query: 530 YKEALVNILKSKAALTK---EHTRIMEHNVTLIESLQNVEKE---AYRELGTIKNELIED 583
++ I L+K E+ + + +E +++V KE R T+K E +
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E L +E+ ++ +++E++ R+L + + ++ DL + ++E
Sbjct: 1909 KESL-QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
Query: 644 NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
++ EL LLR + E++ M+ K+ + +++LKK E
Sbjct: 1968 LQKKIQELQKK-----ELQLLRVK-EDVNMS-HKKINEMEQLKKQFE 2007
Score = 76.2 bits (179), Expect = 4e-13
Identities = 124/631 (19%), Positives = 272/631 (43%), Gaps = 72/631 (11%)
Query: 112 EIRNKDQTICEYNKQIEDYKN---EIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
++ N++ E N DY N + QL+ +E+ K ++ ++ +F ++RK K +
Sbjct: 489 KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548
Query: 169 -------INNTNCHTEHNAVQGTDAE-KVSAMINDMRSRIIELEKKCEALDNEVYDK-QM 219
I+N +H V D E ++S+ + +R + +++K E +D++ + +M
Sbjct: 549 EMQLIHEISNLKNLVKHREVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608
Query: 220 ELS-SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK 278
+LS SLE ++ D K +++ L E + ++ ++ + E + + YK
Sbjct: 609 DLSYSLE---SIEDP--KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYK 663
Query: 279 I---ELEALKTKLDEEKQAIISKCKVDQEN-LKTKHN--ASIESLKNQMLKEKCEALEQL 332
+++ +++L+ +K K +VD E L++ N + SL + + + +L
Sbjct: 664 QMENDIQLYQSQLEAKK-----KMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLEL 718
Query: 333 HSQLIIKEQEMKAKLEQIEESASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIK 391
++ ++E+ ++E+ E E + + E++ + +++ + + + + E
Sbjct: 719 EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD 778
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF------IEEIKTLKDELIEKTIN 445
+L ++ S ++ L + KD+L+T + N+ + KTL + +K
Sbjct: 779 KL---FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD-------SELEQLEDQ 498
E ++N + KE KF++SL + + T L+E +E+EQL++Q
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 499 VQMLTSAKEVLENELTTYKNTLNNTVREC-------DEYKEALVNILKSKAALTKEHTRI 551
++ S + +E E T L T+ E D+ K+ ++ + L +
Sbjct: 896 LENRDSPLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
Query: 552 MEHNVTLIESLQNV---EKEAYRELGTIKNELIEDV--ELLKKESNSQIKFLREEVEKKR 606
+ N+ E L+N K+ + T+K+++ E+V L +E+ + K +E ++K
Sbjct: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK---DEFQQKM 1012
Query: 607 VLCEM---XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSL 663
V + ++ Q S ++ +NE S++ E
Sbjct: 1013 VGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE----LQQMLESVIAEKEQ 1068
Query: 664 LRQE-NEELTMTVAKQSSII---DKLKKDLE 690
L+ + E + MT+ Q + D+LKK E
Sbjct: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Score = 74.9 bits (176), Expect = 9e-13
Identities = 109/504 (21%), Positives = 223/504 (44%), Gaps = 36/504 (7%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
+ ++ E L+ ++E+ Q+ + I K + I+ Q + +
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 188 KVSAMINDMRSRIIELEKKCEALDN-----EVYDKQMELSSLEEVITVRDS--LCKDLQE 240
+ ++ I L ++ E L N E + EL L E T +DS L + E
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII-SKC 299
+L NE E+Q+ ++ + + ++I+ +++ + LK + E I S+
Sbjct: 1330 RLRLNE-KFQESQEEIKSLTKER----DNLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 300 KVDQE-NLKTKHNASIESLKN-QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K +Q N+K K N + + + + K K AL ++ +++ + ++ ++++ A EK
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQE---------IKELKYTLDLTNNQNSDLK 408
+ +Q +S+S Q + +E ++LE E +KE + T++ S+ +
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKF- 467
E++ ++ + ++ + N I+EI +++L K I+ E N+ K KE K
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQLNIKQISEVQE----NVNELKQFKEHRKAK 1560
Query: 468 ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVREC 527
+++L + LT RL+ES E++ + + + + +E L+ E K V +
Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
Query: 528 DEYKEALVNILKSKAA-LTKEHTRIMEHNVTLIE----SLQNVEKEAYRELGTIKNELIE 582
E +E LK A T+E +EH E +L+N+E E R L I +E +E
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR-LTQILHENLE 1679
Query: 583 DVELLKKESNSQIKFLREEVEKKR 606
++ + KE ++ + E ++ +R
Sbjct: 1680 EMRSVTKE-RDDLRSVEETLKVER 1702
Score = 69.7 bits (163), Expect = 3e-11
Identities = 127/622 (20%), Positives = 265/622 (42%), Gaps = 45/622 (7%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS-HNNIDFNEIDR 162
+ V+ + I K Q E K + K+++ QLQE L+ + + H+ ++ N +
Sbjct: 904 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ 963
Query: 163 KLSKLRINNTNCHTEH-NAVQGTDAEKVSA---MINDMRSRIIELEKKCEALDNEVYDKQ 218
+ + + + H E N ++ +E+VS M + E ++K +D + +
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK---QD 1020
Query: 219 MELSSLEEVIT-VRDSLCKDLQEKLTSNELTLAETQQRLEMV---KGHHALALEANESIR 274
+E + + + V+D+ + Q K+ S E QQ LE V K L+ N +
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQL 332
E + EL L +L +++Q I+++ K + + + + + L + LKEK + L++
Sbjct: 1081 IENQEELRLLGDEL-KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 333 HSQLI-IKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
QL+ ++E+ EM+ K+ +IE +E LK E+ E E + + + ++
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNE-LKNKELTLEHMETERLELAQKLNENYEEVKSI 1198
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT----LKD--ELIEKT 443
KE K +L + E ++L+ E+ EE+K LK+ E I++
Sbjct: 1199 TKERKVLKEL----QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 444 INYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL--TLRLRESDSELEQLEDQVQM 501
+EK + + K K + + V + +L ++ E+ + +LE +
Sbjct: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKKVSETQETMNELELLTEQ 1314
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALV----NILKSKAALTKEHTRIMEH--- 554
T+ + + LN +E E ++L N+ K AL +H ++ EH
Sbjct: 1315 STTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRE 1374
Query: 555 NVTLIESLQNVEKEA--YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX 612
+ I+ Q+ ++++ +E +++ ++E K + ++ ++ E + + L E
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 613 XXXXXXXXXXXXXSRVL-LAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE-- 669
R+ + Q+ +D + EN E L V L+++ E
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLK-ENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
Query: 670 -ELTMTVAKQSSIIDKLKKDLE 690
EL + ++++ + I ++K LE
Sbjct: 1494 NELRVNLSEKETEISTIQKQLE 1515
Score = 64.5 bits (150), Expect = 1e-09
Identities = 108/529 (20%), Positives = 248/529 (46%), Gaps = 52/529 (9%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEIL 141
K +K+ L + L + E ++ + ++ +TI + + + NEI+ +Q+ L
Sbjct: 1699 KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL 1758
Query: 142 KELATKFRQSHNNIDFNEIDRKL-SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ H+N D K+ +LRI + + + + +K+ ++++ ++
Sbjct: 1759 E---------HSNDALKAQDLKIQEELRIAHMHLKEQQETI-----DKLRGIVSEKTDKL 1804
Query: 201 IELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNE-LTLAETQQRLEM 258
++K E + ++ +K EL + E ++IT++ + + Q+K++ E L Q L +
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV-NETQKKVSEMEQLKKQIKDQSLTL 1863
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
K L +E N ++ +E LE +K+ + E + +E LK + + ESL+
Sbjct: 1864 SK----LEIE-NLNLAQELHENLEEMKSVMKER-----DNLRRVEETLKLERDQLKESLQ 1913
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQ 378
++ E ++L + ++ +E K ++++ E SEK IQ + + + + +
Sbjct: 1914 ETKARD-LEIQQELKTARML-SKEHKETVDKLREKISEK----TIQISDIQKDLDKSKDE 1967
Query: 379 QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE 438
+K IQ L++ KEL+ L + + N K ++N ++ K + N++ + + +
Sbjct: 1968 LQKKIQELQK--KELQ-LLRVKEDVNMSHK-KINEMEQLKKQFEP---NYLCKCEMDNFQ 2020
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR-LRESDSELEQLED 497
L +K ++ E+ ++ V K E + + SL + RD + TLR + D + Q++
Sbjct: 2021 LTKK-LHESLEEIRI---VAKERDELRRIKESLKMERD-QFIATLREMIARDRQNHQVKP 2075
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVR---ECDEYKEALVNILKSKAALTKEHTRIMEH 554
+ ++L+ ++ L L + + ++ E D++ E L N L E RIM+
Sbjct: 2076 EKRLLSDGQQHLMESLREKCSRIKELLKRYSEMDDHYECL-NRLSLDLEKEIEFHRIMKK 2134
Query: 555 NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++ + +++E + + + + I++VE +KE +I+ L+++ +
Sbjct: 2135 LKYVLSYVTKIKEEQHECINKFEMDFIDEVE-KQKELLIKIQHLQQDCD 2182
Score = 38.3 bits (85), Expect = 0.095
Identities = 38/204 (18%), Positives = 93/204 (45%), Gaps = 12/204 (5%)
Query: 113 IRNKDQTICE----YNKQIEDYKNEIAQLQEILKELATKFRQSHNNI-DFNE-IDRKLSK 166
I+ ++ IC+ +N +I NE + +E ++ ++ Q ++ + NE + +
Sbjct: 2251 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2310
Query: 167 LRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEVYDKQMELSSLE 225
L+ + + + Q V++ + + +I ELE K+ ++ ++
Sbjct: 2311 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ 2370
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL----EANESIRREY-KIE 280
+ + V + + LQ K+ + L +T++ +++++ AL E E ++ + KI+
Sbjct: 2371 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2430
Query: 281 LEALKTKLDEEKQAIISKCKVDQE 304
LE +K + EK+ +K V+ +
Sbjct: 2431 LEKMKNAKEFEKEISATKATVEYQ 2454
Score = 37.9 bits (84), Expect = 0.13
Identities = 72/369 (19%), Positives = 159/369 (43%), Gaps = 24/369 (6%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQ--LQEILKELATKFRQSHNNIDFNEIDRKLSK 166
QD ++ +++ + N+ ++ + EI + + + T+F+Q +N E+ + L +
Sbjct: 2179 QDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNR--KEMTQFLEE 2236
Query: 167 LRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNE--VYDKQME--LS 222
+ N +Q + +++ + N +RII + + + K+ E L
Sbjct: 2237 WLNTRFDIEKLKNGIQ-KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLK 2295
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
SL+E + L+ L S TQ A L E IR E
Sbjct: 2296 SLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL-TTEKIRELENSLHE 2354
Query: 283 ALKTKLDEEKQAIISKCKVDQEN-LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
A ++ + +E + I + +++ N + K A + N+ L++ E ++ L ++ + +
Sbjct: 2355 AKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHE-SNKCLEKTKETIQVLQDKVALGAK 2413
Query: 342 EMKAKLEQIEESASEKLKICEIQFEE--RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
K ++E + K+K+ +I E+ ++ ++ S + T++Y ++ I+ L+ L
Sbjct: 2414 PYKEEIEDL------KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2467
Query: 400 TNN-QNSDLKQELNNLKNCKDELSTEKFN-FIEEIKTLKDELIEKTINYENEKNKLNLAV 457
+ Q++ + E + + L+ + ++ K L L + I E E +KL
Sbjct: 2468 SQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI--LKSEHIRLEKEISKLKQQN 2525
Query: 458 EKAIKEKNK 466
E+ IK+KN+
Sbjct: 2526 EQLIKQKNE 2534
Score = 35.1 bits (77), Expect = 0.89
Identities = 31/139 (22%), Positives = 66/139 (47%), Gaps = 12/139 (8%)
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+FEERS +I + Q K+++ +++ + TL + + + + KN
Sbjct: 2278 EFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2337
Query: 424 EKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
+ E+I+ L++ L E + ++++K+ K + L VT DI+ L
Sbjct: 2338 TQLT-TEKIRELENSLHEAKESAMHKESKII-----------KMQKELEVTNDIIAKLQA 2385
Query: 484 RLRESDSELEQLEDQVQML 502
++ ES+ LE+ ++ +Q+L
Sbjct: 2386 KVHESNKCLEKTKETIQVL 2404
>AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein
protein.
Length = 2585
Score = 88.6 bits (210), Expect = 7e-17
Identities = 128/608 (21%), Positives = 274/608 (45%), Gaps = 52/608 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNID-----FNEIDRKLSKLRINNTNCHTEHNAVQ 182
E ++E QL+E +KE+ K ++ + E + +++LR+N + TE + +Q
Sbjct: 1432 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1491
Query: 183 GTDAEKVSAMINDMRSRIIELEKKCEALD----NEVYDKQMELSSLEEVITVRDSLCKDL 238
+++ A+ + ++++I E+ +K E + +EV +K EL +E +DS + +
Sbjct: 1492 ----KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1547
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+ K+ L E+Q+ +++ + E E R + +++E + +L E + I++K
Sbjct: 1548 ESKMLELTNRLQESQEEIQI------MIKEKEEMKRVQEALQIE--RDQLKENTKEIVAK 1599
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
K QE ++ + N+ ++ CE +E L Q + K LE IE +E +
Sbjct: 1600 MKESQEK---EYQFLKMTAVNETQEKMCE-IEHLKEQF----ETQKLNLENIE---TENI 1648
Query: 359 KICEIQFE--ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK- 415
++ +I E E +S+ + + L+ E +LK L T ++ + ++EL +
Sbjct: 1649 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1708
Query: 416 NCKDELST-EKFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIK----EKNKFET 469
+ K+ T +K I KT + ++K + + N+ K +L +++ ++ + +
Sbjct: 1709 HLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQE 1768
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
++ R IV T +L +LE ++Q + E++L T K +N T ++ E
Sbjct: 1769 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1828
Query: 530 YKEALVNILKSKAALTK---EHTRIMEHNVTLIESLQNVEKE---AYRELGTIKNELIED 583
++ I L+K E+ + + +E +++V KE R T+K E +
Sbjct: 1829 MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1888
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E L +E+ ++ +++E++ R+L + + ++ DL + ++E
Sbjct: 1889 KESL-QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1947
Query: 644 NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLR 703
++ + E LL + LT ++ ++ S I +L K S+ + R
Sbjct: 1948 LQK--KQDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK--RYSEMDDHYECLNR 2003
Query: 704 KSLKVGKE 711
SL + KE
Sbjct: 2004 LSLDLEKE 2011
Score = 74.9 bits (176), Expect = 9e-13
Identities = 118/523 (22%), Positives = 243/523 (46%), Gaps = 49/523 (9%)
Query: 124 NKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRINNTNCHTEHNAV 181
N+ E+ K+ I + +++LKEL F +++ EI+ + + H
Sbjct: 1169 NENYEEVKS-ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1227
Query: 182 QGTDAEKVSAMINDMRSRII---ELEKKCEALDNEV---YDKQMELSSLEEVITVRDSLC 235
Q T +++ +++ ++II +LEK L E+ +++Q L +++EV ++++
Sbjct: 1228 QET-IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN 1286
Query: 236 K-DL--QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE---YKIELEALKTKLD 289
+ +L ++ T + TLA + + + E +S+ +E K EAL+ K D
Sbjct: 1287 ELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD 1346
Query: 290 EEKQAI------ISKCKVDQE---NLKTKHNASIESLKN-QMLKEKCEALEQLHSQLIIK 339
+ K+ I I + + QE N+K K N + + + + K K AL ++ +++
Sbjct: 1347 QLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGL 1406
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE---------I 390
+ ++ ++++ A EK + +Q +S+S Q + +E ++LE E +
Sbjct: 1407 SKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL 1466
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
KE + T++ S+ + E++ ++ + ++ + N I+EI +++ K I+ EK
Sbjct: 1467 KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1526
Query: 451 -NKLNLAVEKAIKEKNKF-ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
N+L K KE K +++L + LT RL+ES E++ + + + + +E
Sbjct: 1527 VNEL-----KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA 1581
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAA-LTKEHTRIMEHNVTLIE----SLQ 563
L+ E K V + E +E LK A T+E +EH E +L+
Sbjct: 1582 LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE 1641
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
N+E E R L I +E +E++ + KE ++ + E ++ +R
Sbjct: 1642 NIETENIR-LTQILHENLEEMRSVTKE-RDDLRSVEETLKVER 1682
Score = 74.1 bits (174), Expect = 2e-12
Identities = 143/685 (20%), Positives = 290/685 (42%), Gaps = 110/685 (16%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
KI K NS+ P N +L +R D+++C + + + N + L
Sbjct: 432 KINKMKNSNYADQSNIPTNITTKTHKLSINL---LREIDESVCS---ESDVFSNTLDTLS 485
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
EI ATK N I+ +L+ LR + N ++ ++ T+ E++ + +
Sbjct: 486 EIEWNPATKLLNQEN------IESELNSLRADYDNLVLDYEQLR-TEKEEMELKLKEKN- 537
Query: 199 RIIELEKKCEALDNEVY-DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
+L++ EAL+ + D++ ELSS E++ ++ K LQE + S Q+LE
Sbjct: 538 ---DLDE-FEALERKTKKDQENELSSKVELLREKEDQIKKLQEYIDS---------QKLE 584
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI-ES 316
+K + +LE+ E ++ + +A LD ++++ + + + K K A+ +
Sbjct: 585 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 644
Query: 317 LKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESAS------EKLKICEIQFEER 368
++N Q+ + + EA +++ L E+E+++ +I + S K +C ++ E +
Sbjct: 645 MENDIQLYQSQLEAKKKMQVDL---EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 701
Query: 369 SQSIQEHCSQQEKTIQYLEQEI------KELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
+Q+ +++ + + L +E+ K L ++ + D +EL+ + + KD+L
Sbjct: 702 ITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 761
Query: 423 TEKFN-------FIEEIKTLKDELIEKTINYEN------------------------EKN 451
+E + +EEI KD+L NY++ E
Sbjct: 762 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 821
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD-------SELEQLEDQVQMLTS 504
++N + KE KF++SL + + T L+E +E+EQL++Q++ S
Sbjct: 822 RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 881
Query: 505 AKEVLENELTTYKNTLNNTVREC-------DEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+ +E E T L T+ E D+ K+ ++ + L + + N+
Sbjct: 882 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 941
Query: 558 LIESLQNV---EKEAYRELGTIKNELIEDV--ELLKKESNSQIKFLREEVEKKRVLCEM- 611
E L+N K+ + T+K+++ E+V L +E+ + K +E ++K V +
Sbjct: 942 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK---DEFQQKMVGIDKK 998
Query: 612 --XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQE-N 668
++ Q S ++ +NE S++ E L+ +
Sbjct: 999 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE----LQQMLESVIAEKEQLKTDLK 1054
Query: 669 EELTMTVAKQSSII---DKLKKDLE 690
E + MT+ Q + D+LKK E
Sbjct: 1055 ENIEMTIENQEELRLLGDELKKQQE 1079
Score = 68.9 bits (161), Expect = 6e-11
Identities = 127/622 (20%), Positives = 264/622 (42%), Gaps = 45/622 (7%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS-HNNIDFNEIDR 162
+ V+ + I K Q E K + K+++ QLQE L+ + + H+ ++ N +
Sbjct: 884 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ 943
Query: 163 KLSKLRINNTNCHTEH-NAVQGTDAEKVSA---MINDMRSRIIELEKKCEALDNEVYDKQ 218
+ + + + H E N ++ +E+VS M + E ++K +D + +
Sbjct: 944 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK---QD 1000
Query: 219 MELSSLEEVIT-VRDSLCKDLQEKLTSNELTLAETQQRLEMV---KGHHALALEANESIR 274
+E + + + V+D+ + Q K+ S E QQ LE V K L+ N +
Sbjct: 1001 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1060
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQL 332
E + EL L +L +++Q I+++ K + + + + + L + LKEK + L++
Sbjct: 1061 IENQEELRLLGDEL-KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1119
Query: 333 HSQLI-IKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
QL+ ++E+ EM+ K+ +IE +E LK E+ E E + + + ++
Sbjct: 1120 QQQLLNVQEEMSEMQKKINEIENLKNE-LKNKELTLEHMETERLELAQKLNENYEEVKSI 1178
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT----LKD--ELIEKT 443
KE K +L + E ++L+ E+ EE+K LK+ E I++
Sbjct: 1179 TKERKVLKEL----QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1234
Query: 444 INYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL--TLRLRESDSELEQLEDQVQM 501
+EK + + K K + + V + +L + E+ + +LE +
Sbjct: 1235 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1294
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALV----NILKSKAALTKEHTRIMEH--- 554
T+ + + LN +E E ++L N+ K AL +H ++ EH
Sbjct: 1295 STTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRE 1354
Query: 555 NVTLIESLQNVEKEA--YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX 612
+ I+ Q+ ++++ +E +++ ++E K + ++ ++ E + + L E
Sbjct: 1355 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1414
Query: 613 XXXXXXXXXXXXXSRVL-LAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE-- 669
R+ + Q+ +D + EN E L V L+++ E
Sbjct: 1415 DEMKSVAKEKDDLQRLQEVLQSESDQLK-ENIKEIVAKHLETEEELKVAHCCLKEQEETI 1473
Query: 670 -ELTMTVAKQSSIIDKLKKDLE 690
EL + ++++ + I ++K LE
Sbjct: 1474 NELRVNLSEKETEISTIQKQLE 1495
Score = 57.2 bits (132), Expect = 2e-07
Identities = 117/569 (20%), Positives = 250/569 (43%), Gaps = 73/569 (12%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEIL 141
K +K+ L + L + E ++ + ++ +TI + + + NEI+ +Q+ L
Sbjct: 1679 KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL 1738
Query: 142 KELATKFRQSHNNIDFNEIDRKL-SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ H+N D K+ +LRI + + + + +K+ ++++ ++
Sbjct: 1739 E---------HSNDALKAQDLKIQEELRIAHMHLKEQQETI-----DKLRGIVSEKTDKL 1784
Query: 201 IELEKKCEALDNEVYDKQMELSSLE-EVITVRD---------SLCKDLQEKLTSNELTLA 250
++K E + ++ +K EL + E ++IT++ S + L++++ LTL+
Sbjct: 1785 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS 1844
Query: 251 ETQ-QRLEMVKGHHALALEANESIRRE----YKIELEALKTKLDEEKQAIISKCKVD--- 302
+ + + L + + H LE +S+ +E ++E E LK + D+ K+++ D
Sbjct: 1845 KLEIENLNLAQKLHE-NLEEMKSVMKERDNLRRVE-ETLKLERDQLKESLQETKARDLEI 1902
Query: 303 QENLKT------KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE 356
Q+ LKT +H +++ L+ + + EK + + L + E++ K ++
Sbjct: 1903 QQELKTARMLSKEHKETVDKLR-EKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVKP 1961
Query: 357 KLKICEIQFEERSQSIQEHCSQ-QEKTIQYLEQEIK-ELKYTLDLTNNQNSDLKQELNNL 414
+ ++ + ++S++E CS+ +E +Y E + E L L + + ++EL+
Sbjct: 1962 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMR 2021
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-----NKFET 469
L + IE++ T ++ + +K K L+ IKE+ NKFE
Sbjct: 2022 VKANLSLPYLQTKHIEKLFT-ANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM 2080
Query: 470 SL--SVTRDIVHVLTLRLRESD-----SELEQLEDQVQMLTSAKEVL----ENEL----T 514
V + ++ ++ + D EL L+ M +E+L E+E T
Sbjct: 2081 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT 2140
Query: 515 TYKNTLNNTVRECDEYKEALVN----ILKSKAALTKEHTRIMEHN---VTLIESLQNVEK 567
++ L+N +E ++ E +N I K K + KE+ RI + N I ++ N
Sbjct: 2141 EFQQVLSNR-KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNEST 2199
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIK 596
E TI E +D++ LK+++ K
Sbjct: 2200 EFEERSATISKEWEQDLKSLKEKNEKLFK 2228
Score = 42.7 bits (96), Expect = 0.004
Identities = 95/458 (20%), Positives = 202/458 (44%), Gaps = 51/458 (11%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATK 147
+++TL ++++ + +A+D+EI+ + +T +K+ +K + +L+E + E +
Sbjct: 1877 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE---HKETVDKLREKISEKTIQ 1933
Query: 148 FRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG----TDA--EKVSAMINDMRSRII 201
++D ++ + + + R N+ + G T++ EK S I ++ R
Sbjct: 1934 ISDIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDGQQHLTESLREKCSR-IKELLKRYS 1992
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEV-ITVRDSLC------KDLQEKLTSNELTLAETQQ 254
E++ E L+ D + E+ +E+ + V+ +L K +++ T+N+ E +
Sbjct: 1993 EMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHR 2052
Query: 255 RLEMVKGHHALALEANESIRREY-KIELEALKTKLDEEKQAIIS------KCKVDQENLK 307
++ +K + + E K E++ + +++++K+ +I C V L+
Sbjct: 2053 IMKKLKYVLSYVTKIKEEQHESINKFEMDFID-EVEKQKELLIKIQHLQQDCDVPSRELR 2111
Query: 308 T-KHNASIESLKNQMLKEKCEA----LEQLHSQLIIKEQEMKAKLEQIEESAS--EKLK- 359
K N +++ ++LK+ E+ ++ Q++ +EM LE+ + EKLK
Sbjct: 2112 DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2171
Query: 360 --------ICEIQ--FEERSQSIQEHCSQQEK---TI-QYLEQEIKELKYTLDLTNNQNS 405
IC++ F R +I ++ E+ TI + EQ++K LK +
Sbjct: 2172 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2231
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKT-LKDELIEKTINYENEKNKLNLAVEKAIKEK 464
LK L + K + T L E I + N +E + + E I
Sbjct: 2232 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII-- 2289
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQML 502
K + L VT DI+ L ++ ES+ LE+ ++ +Q+L
Sbjct: 2290 -KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVL 2326
Score = 39.9 bits (89), Expect = 0.031
Identities = 86/417 (20%), Positives = 179/417 (42%), Gaps = 37/417 (8%)
Query: 70 LKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIED 129
LK+ KI + + SI K +++ Q EL+ ++I++ Q ++++ D
Sbjct: 2057 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL----IKIQHLQQDCDVPSRELRD 2112
Query: 130 YK---NEIAQLQEILKELA--------TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEH 178
K N ++EILK+ + T+F+Q +N E+ + L + +
Sbjct: 2113 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNR--KEMTQFLEEWLNTRFDIEKLK 2170
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNE--VYDKQME--LSSLEEVITVRDSL 234
N +Q + +++ + N +RII + + + K+ E L SL+E
Sbjct: 2171 NGIQ-KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2229
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQA 294
+ L+ L S TQ A L E IR EA ++ + +E +
Sbjct: 2230 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL-TTEKIRELENSLHEAKESAMHKESKI 2288
Query: 295 IISKCKVDQEN-LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
I + +++ N + K A + N+ L++ E ++ L ++ + + K ++E +
Sbjct: 2289 IKMQKELEVTNDIIAKLQAKVHE-SNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL--- 2344
Query: 354 ASEKLKICEIQFEE--RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQE 410
K+K+ +I E+ ++ ++ S + T++Y ++ I+ L+ L + Q++ + E
Sbjct: 2345 ---KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISE 2401
Query: 411 LNNLKNCKDELSTEKFN-FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
+ + L+ + ++ K L L + I E E +KL E+ IK+KN+
Sbjct: 2402 HTDPQPSNKPLTCGGGSGIVQNTKALI--LKSEHIRLEKEISKLKQQNEQLIKQKNE 2456
>AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein.
Length = 948
Score = 88.6 bits (210), Expect = 7e-17
Identities = 122/519 (23%), Positives = 229/519 (44%), Gaps = 37/519 (7%)
Query: 100 LPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE 159
+ Q E+ ++ ++NK I + +++ E+ LQ L+ L +F S +I+
Sbjct: 423 MKQMEVYRSHSKFMKNK---IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEV-- 477
Query: 160 IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQM 219
+ L+ TE +A++ EK M+N +I ++ ++ E++D +
Sbjct: 478 LKESLTAKEQRAAILQTEVDALRLRLEEK-ETMLNKKTKQIQDMAEEKGTQAGEIHDLKD 536
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA---LALEANESIRRE 276
L E + V ++LQE+L E ++ ++R++ ++ AL E E
Sbjct: 537 MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAE 596
Query: 277 YKIELEALKTKLDE---EKQAIISKCKVDQENLKTKHNASIESL--KNQMLKEKCEALEQ 331
+ +E LK + D EKQ I K D ++LK K + L K L + E
Sbjct: 597 KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 656
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQE 389
L S + K+ +K +E+ E LK+ E Q ++ ++ E + E + IQ+LE+E
Sbjct: 657 LASSGLKKDSRLKTLEIALEQKKEECLKM-ESQLKKAHEAALEARASPEMSDRIQHLERE 715
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
I K +++S + E++ L E+ EK + ++I L + L + + +N+
Sbjct: 716 ITRYK-------DESSKAQAEVDRLLEILKEVENEKNDKDKKIAEL-ESLTSRQVKDQNK 767
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
K NL ++ + EK K L R L +S +L QV+ L A E +
Sbjct: 768 K-VANLKHKEQV-EKKKSAQMLEEARRRED----NLNDSSQQL-----QVEELLMAMEKV 816
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ EL + K L++T + E + L N L+++ E M+ L + A
Sbjct: 817 KQELESMKAKLSSTQQSLAEKETHLTN-LRAERRKHLEEVLEMKQEALLAAISEKDANIA 875
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
EL + K + E+V LK+E + ++ L+++ + + L
Sbjct: 876 LLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 914
Score = 66.1 bits (154), Expect = 4e-10
Identities = 105/495 (21%), Positives = 212/495 (42%), Gaps = 46/495 (9%)
Query: 132 NEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
N I LQ LKE+ + N++ +++ K SKL + + T + +K A
Sbjct: 149 NTIMDLQTQLKEVLRE-----NDLLRKDVEVKESKLSSSMNSIKT----FWSPELKKERA 199
Query: 192 MINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN--ELTL 249
+ D S+I +++ + E QM + +L++ + ++ L + Q+ +S E +
Sbjct: 200 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCV 259
Query: 250 AE-TQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQ-E 304
AE T++ + + H + +R+ E ++ +E K L+ ++I ++ Q +
Sbjct: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
Query: 305 NLKTK-----HNASIESLKNQMLKEKCEAL-EQLHSQLIIKEQEMKAKLEQIEESASEKL 358
L K H + + +M E+L EQ + + +EM + E +SA K
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSA--KT 377
Query: 359 KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
K + E + I S E+ ++ LE+EI+ LK L+ + + +++ ++
Sbjct: 378 KALQTVIEMKDSKI----SSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVE--KAIKEK-NKFETSLSVTR 475
+ + +E+ EL+ E N+ + + + + +KE E ++ +
Sbjct: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
V L LRL E ++ L + Q+Q + K E+ K+ L + KE V
Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML--------DVKERKV 545
Query: 536 NILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEAYRELGTIKNELIE---DVELLK 588
N+L+ K +E R E ++ ++SLQ L T++ L E +E LK
Sbjct: 546 NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 605
Query: 589 KESNSQIKFLREEVE 603
++ + + +EE++
Sbjct: 606 EQRDRDEREKQEEID 620
Score = 58.4 bits (135), Expect = 8e-08
Identities = 96/501 (19%), Positives = 200/501 (39%), Gaps = 32/501 (6%)
Query: 205 KKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA 264
K+ L + + ++ + + ++ + RD K L E L S L+ T++ E +
Sbjct: 279 KELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR---R 335
Query: 265 LALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKE 324
LA EA + + LE + + ++ + + + ++ KTK ++ +K+ +
Sbjct: 336 LA-EAEMHVHHLESL-LEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISS 393
Query: 325 KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQ 384
L L ++ Q +K+ E E++K E+ + S+ ++ Q ++ +
Sbjct: 394 MERGLRDLEEEI----QMLKSNGALSTEEREEEMKQMEV-YRSHSKFMKNKIGQVKQELS 448
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
+ E+ L+ L+ NQ SD KQ + LK E+ L+ L EK
Sbjct: 449 RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK-- 506
Query: 445 NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
E NK ++ +EK + +D++ V ++ ++E L++Q++
Sbjct: 507 --ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 564
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
L+ + + + NT +EAL ++ L ++ R I++ +
Sbjct: 565 QMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKK 624
Query: 565 VEKEAYRELGTIKNELIE-DVELLK-KE-----------SNSQIKFLREEVEKKRVLCEM 611
K+ ++ ++ +L E + LL KE +S++K L +E+K+ C
Sbjct: 625 DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK 684
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE-LSLLRQ-ENE 669
+R + + + LE E RY + V L +L++ ENE
Sbjct: 685 MESQLKKAHEAALEARA-SPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE 743
Query: 670 --ELTMTVAKQSSIIDKLKKD 688
+ +A+ S+ + KD
Sbjct: 744 KNDKDKKIAELESLTSRQVKD 764
>AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-1
protein.
Length = 685
Score = 87.8 bits (208), Expect = 1e-16
Identities = 117/454 (25%), Positives = 208/454 (45%), Gaps = 43/454 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDK-QMELSSLEEVITVRDS---LCKDLQEK 241
A++ A IN + L K+CEA + + K + EL +L + + + +C L ++
Sbjct: 8 AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQE 67
Query: 242 LTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKV 301
T E + E + LE LE+ SI ++ + LK KL+ + Q I +
Sbjct: 68 NTFVEQVVNEKVKHLEDTLKE----LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFH 123
Query: 302 DQENLKTKHN----------ASIESLKNQML---KEKCEALEQLHSQL-IIKEQEMK--A 345
++E+L+ K N IE LK+++ K+ C +EQ + ++ +KEQ K +
Sbjct: 124 EREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEIS 183
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCS--QQEKTIQYLEQE-IKELKYTLDLTNN 402
+L + S SEK K+ + FE Q ++E C QQEK L E ++E+ L
Sbjct: 184 ELNETFLSDSEKEKLT-LMFE--IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 240
Query: 403 QNSD-LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+++ + QE ++K + E + T KD L+E + E KL L+ ++ +
Sbjct: 241 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKL-LSQQELV 299
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
E E ++ ++ V L L + D+ L++LE ++ LT K+ N+L ++
Sbjct: 300 PE---LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD 356
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT-----LIESLQNVEK--EAYRELG 574
N ++C E +E L+ L K T ++ +E V L E+L+ ++ + +L
Sbjct: 357 NFHKKC-EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLM 415
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
L ED E+L E S + V+KK+ L
Sbjct: 416 VQMKVLSEDKEVLSAEVKSLYEETINSVQKKKQL 449
Score = 78.2 bits (184), Expect = 1e-13
Identities = 110/489 (22%), Positives = 216/489 (44%), Gaps = 42/489 (8%)
Query: 120 ICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHN 179
+C+ ++++ EI +L E+ + L + S NI + + +L LR +N + ++
Sbjct: 1 MCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ-KKYECELENLRKATSNANQDNQ 59
Query: 180 AV-----QGTDAEKV-SAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRD 232
+ T E+V + + + + ELE + L +EV Y ++L + ++D
Sbjct: 60 ICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKD 119
Query: 233 SLCKDLQE-KLTSNELTLAETQQR--LEMVKGHHALALEANESIRREYKIELEALKTKLD 289
+ ++ + NEL LA+ +Q +E +K A + ++ E+++LK +
Sbjct: 120 EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ 179
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQ---MLKEKCEAL---EQLHSQLIIKEQEM 343
+E + D E K I+ LK Q + +EK EA+ E L + I + E+
Sbjct: 180 KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 239
Query: 344 ---KAKLEQIEESASEKLK--ICEIQ------FEE---------RSQSIQEHCSQQEKTI 383
K+ Q ES ++ + E+Q F E R Q E Q++ +
Sbjct: 240 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 299
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
LE IK L+ + S L L+ + L+ EK +FI ++K +E+
Sbjct: 300 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 359
Query: 444 INYENEKN---KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
E E+ +L VE+ I+ ++ E ++ + ++D +LE+L Q++
Sbjct: 360 KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMK 419
Query: 501 MLTSAKEVLENEL-TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTL- 558
+L+ KEVL E+ + Y+ T+N+ ++ ++ V + + + + KEH +E + L
Sbjct: 420 VLSEDKEVLSAEVKSLYEETINSVQKKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLM 479
Query: 559 IESLQNVEK 567
+E N+ K
Sbjct: 480 VEEQDNLNK 488
Score = 64.5 bits (150), Expect = 1e-09
Identities = 108/511 (21%), Positives = 221/511 (43%), Gaps = 44/511 (8%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q E+ + + + + ++ +I+ K + LQ+ +E + ++ + +
Sbjct: 179 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTE 238
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
S +I+ E +++ A V + +R+ E + E + N + + +L
Sbjct: 239 LGESAGKISQ-----EFESMKQQQASDVHELQQKLRTAFTEKDALLETV-NRLQGENEKL 292
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALEANESIRR--EYK 278
S +E++ ++ K+LQEK L+L++ L+ ++G ++L E ++ I +
Sbjct: 293 LSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 352
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM-------LKEKCE---A 328
E++ K + E++ I+ K ++ ++ +N+ +E N++ LKEK +
Sbjct: 353 EEMDNFHKKCEREERLILELGKKVEQTIQ--YNSELEQKVNELTGGLEETLKEKDQNDQK 410
Query: 329 LEQLHSQL-IIKEQ------EMKAKLEQIEESASEKLKIC---EIQFEERSQSI-QEHCS 377
LE+L Q+ ++ E E+K+ E+ S +K ++ E+ ++ I +EH +
Sbjct: 411 LEKLMVQMKVLSEDKEVLSAEVKSLYEETINSVQKKKQLSRDLEVFLSQKEDVILKEHIT 470
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN-LKNCKDELSTEKFNFIEEIKTLK 436
Q EK +Q + +E L L+ Q +K +L LK E+S + +++ +
Sbjct: 471 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEE--KDVVNVL 528
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR--LRESDSELEQ 494
+ E EK L ++ + E K E +V L+ LR+ + E
Sbjct: 529 QAVGESLAKINEEKCNLAFQRDEKVLELEK-EIKCLQEESVVQCEELKSLLRDYEQEKVL 587
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD----EYKEALVNILKSKAALTKEHTR 550
L +++ + S KE L+++L KN T E + +E KS+ KE
Sbjct: 588 LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 647
Query: 551 IMEHNVTLIESLQNVE-KEAYRELGTIKNEL 580
I EH L L+ E ++ EL +K+ L
Sbjct: 648 IKEHE-NLKPLLEQKELRDRRAELILLKDSL 677
Score = 53.6 bits (123), Expect = 2e-06
Identities = 68/366 (18%), Positives = 159/366 (43%), Gaps = 24/366 (6%)
Query: 98 KILPQDELVQAQDVEIRNKDQ-------TICEYNKQIEDYKNEIAQLQEILKELATKFRQ 150
K+L Q ELV + I+N + ++ + + +++ + +I L E + K +
Sbjct: 291 KLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN 350
Query: 151 SHNNID-FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEA 209
SH +D F++ + +L I E ++ E+ +N++ + E K+ +
Sbjct: 351 SHEEMDNFHKKCEREERL-ILELGKKVEQTIQYNSELEQ---KVNELTGGLEETLKEKDQ 406
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA 269
D ++ +++ L E V + K L E+ T+ Q++ ++ + +
Sbjct: 407 NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE------TINSVQKKKQLSRDLEVFLSQK 460
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL 329
+ I +E+ +LE K +L E+Q ++K +++ K + +M E E
Sbjct: 461 EDVILKEHITQLEK-KLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDS 519
Query: 330 EQLHSQLIIKEQ-EMKAKLEQIEESASEKLKICEIQFEERSQSIQEH----CSQQEKTIQ 384
E+ +++ E AK+ + + + + + ++ E+ + +QE C + + ++
Sbjct: 520 EEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLR 579
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
EQE L+ L+ ++ L+ +L +KN ++ E N + +++ + + I
Sbjct: 580 DYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI 639
Query: 445 NYENEK 450
+ E EK
Sbjct: 640 HNEKEK 645
Score = 40.7 bits (91), Expect = 0.018
Identities = 90/409 (22%), Positives = 171/409 (41%), Gaps = 62/409 (15%)
Query: 327 EALEQLHSQLIIKEQEMKAKL-EQIEESASEKLKICEIQFEE----RSQSIQEH--CS-- 377
EA + H I K E+K L +Q E S K E + E S + Q++ CS
Sbjct: 5 EASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSIL 64
Query: 378 QQEKTI--QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTL 435
QE T Q + +++K L+ TL +Q+S LK E+ + N K +L + + +
Sbjct: 65 LQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDA-------QHI 117
Query: 436 KDELIEKTINYENEKNKLNLAVEK--AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
KDE + + E + N+L LA E+ + EK K E + + + + + RE S E
Sbjct: 118 KDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELA-GLNKQFCYTVEQHNREVQSLKE 176
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
Q + ++ L E ++ K TL + E KE N+ + K +
Sbjct: 177 QHQKEISELN---ETFLSDSEKEKLTL---MFEIQGLKEQCENLQQEK-----------Q 219
Query: 554 HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXX 613
+ ESL+ + + ELG ++ ++ E +K++ S + L++++
Sbjct: 220 EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLR---------- 269
Query: 614 XXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM 673
+ L + ++RL+ ENE+ L + L+++N +
Sbjct: 270 --------TAFTEKDALLET---VNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 318
Query: 674 TVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRER 722
+++++ +++ +L+ + + T + + K LK E M ER
Sbjct: 319 SLSQRDTMLKELEGKI--NSLTEEKDDFINK-LKNSHEEMDNFHKKCER 364
>X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein.
Length = 2185
Score = 87.0 bits (206), Expect = 2e-16
Identities = 122/544 (22%), Positives = 255/544 (46%), Gaps = 51/544 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK---ELATKFRQSH 152
K K+ ++ D E ++ + + NK +ED E +L E L ++ K ++
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
Query: 153 NNIDFNE-IDRKLSKLR-INNTNCHTEHNAVQGTDAEKV-SAMINDMRSRIIELEKKCEA 209
NE I+ SK I + H +H + +A + + ++++ +++ +L ++
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 210 LD-------NEVYDKQMELSSL----EEVITVRDSLCKDL-QEKLTSNELTLAETQQRLE 257
L+ +++ +K+ ++ S+ E ++T +++L K+ ++ ++E TQ + E
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
+ + +A+ L E +E K+E+ +L +L + + + + ++ A+I SL
Sbjct: 1348 LSENINAVTLMKEEL--KEKKVEISSLSKQLTDLNVQLQNSISLSEKE------AAISSL 1399
Query: 318 KNQMLKEKCEALEQ---LHSQLIIKEQEMKAKLEQIEE---SASEKLKICEIQFEERSQS 371
+ Q +EKCE L+Q L ++ +E + LEQ+++ SE K + +F + +
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
Query: 372 IQEHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCKDELSTE 424
++E Q E K +++I LK LD N + LK E+ + ++ + L TE
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
+ I L+D + +KTI E+ L N +K I+ K + L +++
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ-KLQHFQELGEEKDN 1578
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK-A 542
R++E++ ++ LE+QV + + E + EL +N +V+ +E +AL + L+S+ A
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKEL----EHVNLSVKSKEEELKALEDRLESESA 1634
Query: 543 ALTKEHTRIMEHNVTLIES---LQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
A E R E + I+ Q EKE + GT + + ++ +E ++ L
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH--LSELNTKLQEREREVHILE 1692
Query: 600 EEVE 603
E+++
Sbjct: 1693 EKLK 1696
Score = 80.2 bits (189), Expect = 2e-14
Identities = 120/653 (18%), Positives = 285/653 (43%), Gaps = 58/653 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ-L 137
K +A ++K L+ + + +L D +I+ ++T E ++ + + Q +
Sbjct: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+++K+ + + + E+ RK +L T Q E++ + +
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQEL---TKKLQTREREFQ----EQMKVALEKSQ 519
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
S +++ ++ E ++ + ++EL + ++T ++ +DLQ++ + + E + LE
Sbjct: 520 SEYLKISQEKEQQESLALE-ELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLE 577
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
+L+ N++ ++ + LEA K K ++E ++ K H +ESL
Sbjct: 578 K-------SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK-----------HKTELESL 619
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES-ASEKLKICEIQFEERSQSIQEHC 376
K+Q E L+ L Q + ++++ K EQ +E+ +K I + EE ++ E
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKT- 434
++ ++ L E+ E+ + S LK + + +K + ++ +K + +++ +
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+K+ + + K+++N +E +KE++K L + V L ++ S+ EL+Q
Sbjct: 740 IKEHEVSIQRTEKALKDQIN-QLELLLKERDK---HLKEHQAHVENLEADIKRSEGELQQ 795
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEH----TR 550
++ + S + + Y+ L ++ + + + + K A + + T
Sbjct: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 551 IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK-KRVLC 609
+ H + + + +Q +EK+ +E+ + V+ L + S+++ +E E+ K++L
Sbjct: 856 LDAHKIQVQDLMQQLEKQ--------NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 907
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E +L + +A + NE Y ++ ++Q+ +
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK---KMEKVKQKAK 964
Query: 670 ELTMTVAKQSSIID---KLKKDLEQS--QYTPKSPSVLRKSLKVGKENMQTIS 717
E+ T+ K+ ++D KLKK+LE + + + K K L++ + N IS
Sbjct: 965 EMQETLKKK--LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
Score = 69.3 bits (162), Expect = 4e-11
Identities = 125/610 (20%), Positives = 255/610 (41%), Gaps = 55/610 (9%)
Query: 119 TICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINNTNCHT 176
T+ E Q+E E + E + L + Q + D E++ SK+ +N T
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-------LSSLEEVIT 229
E + ++ + + + + IE+E E L N K +E L +E+
Sbjct: 1519 ELKS----QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 230 VRDSLCKDLQEKLTSNELTLAETQQRLEMVKG---HHALALEANES--------IRREYK 278
+D+ K+ +EK+ + E + + LE K H L++++ E + E
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
Query: 279 IELEALKTKLDEE----KQAIISKCKVDQENLKTKHNASIESLKNQM---------LKEK 325
+L LK K +++ K+ ++S+ + +E K + + L ++ L+EK
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+++E S+ +I + K E+ ++ + +EE+ +Q + +++EK +Q
Sbjct: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR 1754
Query: 386 LEQEIKE-LKYTLDL-TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ QE +E + ++ Q +K E K +D+ E K K LI
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQ 1814
Query: 444 INYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLRLRESDSELEQLED----Q 498
+ E E K N+ ++ ++ + + +L +L +++E DS L + ++ +
Sbjct: 1815 -HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE 1873
Query: 499 VQMLTSAKEVLEN-ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
++ LTS E L+ + +N + E E K + ++++ K E +HN
Sbjct: 1874 MEELTSKYEKLQALQQMDGRNKPTELLEENTEEK-SKSHLVQPKLLSNME----AQHN-D 1927
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
L L E+E ++LG L +D+ +L+KE +++ L++E +++R ++
Sbjct: 1928 LEFKLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQED 1985
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
+ L+ + L++ E E E + VE LL EE + K
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELE-MTIKETINKAQEVEAELLESHQEETNQLLKK 2044
Query: 678 QSSIIDKLKK 687
+ D LK+
Sbjct: 2045 IAEKDDDLKR 2054
Score = 68.9 bits (161), Expect = 6e-11
Identities = 102/564 (18%), Positives = 239/564 (42%), Gaps = 49/564 (8%)
Query: 80 ITKAPNSSIKKTLTCPKNKILPQ-DELVQAQDVEIRNKDQTICEYNKQI-------EDYK 131
+T+ + ++ + K+ Q +EL + +++++ K+Q + E ++I E+
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 1091
Query: 132 NEIAQLQE-------ILKELATKFRQSHNNI-----DFNEIDRKLSKLRINNTNCHTEHN 179
EI L+E L EL + +Q ++ D ++ L KL ++ E+
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
+Q E + + + + ++ EL K + D E + + + + K L
Sbjct: 1152 FLQEQLVE-LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLS 1210
Query: 240 EKLTSN-ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
E+L ++ +T+ LE K + + + ++++ + + + + K+A++ K
Sbjct: 1211 EELAIQLDICCKKTEALLE-AKTNELINISSSKT--NAILSRISHCQHRTTKVKEALLIK 1267
Query: 299 -CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQI--EESAS 355
C V + + + ++ N ++ LE+ +Q+ + MKA +E + E+ A
Sbjct: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI----KSMKADIESLVTEKEAL 1323
Query: 356 EKLKICEIQFEERSQS----IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL 411
+K + Q +S +++ S+ + +++E+KE K + + Q +DL +L
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 412 NN---LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKF- 467
N L + +S+ + + EE L D++ + + + + A+E+ NKF
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 468 ------ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
++ + ++ V L ++L E + ++Q+ +L + K +
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ + ++ + L LKS+ A E + IESL V K ++ EL+
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 582 EDV---ELLKKESNSQIKFLREEV 602
+ + + L +E ++++K E++
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKI 1587
Score = 58.0 bits (134), Expect = 1e-07
Identities = 109/547 (19%), Positives = 235/547 (42%), Gaps = 53/547 (9%)
Query: 202 ELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+++ + E L +++ +K+ + L + S E +T+ ++ E ++ ++
Sbjct: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
+L +R E +++ +A K L EE A + + L+T+ + + L+N
Sbjct: 179 SQSQDKSLRRIAELREELQMDQQA-KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 320 -QMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESAS---------EKLKICEIQFEE 367
M + + L QL Q + KE+ ++ E + E + +++K E +
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
Query: 368 RSQSIQEH---C----SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++IQ H C S++E + L++ ++EL+ DL + + L +L + KN ++
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 421 LSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
L +K I E K E + E+ + ++ E+ ++K K E + +
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 477 IVHVLTLRLRESDSELE-QLEDQVQML--TSAKE--VLENELTTYKNTLNNTVRECDEYK 531
+ E+ +L+ ++++Q++ + TS +E L+ EL+ K + + +++ E +
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
A + L K KE L + LQ E+E ++ + + + +E
Sbjct: 478 IAKLQKLHEKELARKEQ--------ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 592 NSQIKFLREEVE--KKRVLCEM-XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYX 648
Q EE+E KK +L E +R+L +++ + S EN+N+
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ--- 586
Query: 649 XXXXXXXSLVVELSLLR-QENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
L V L + + N+E+T+ V K + ++ LK + + +T K VL++ +
Sbjct: 587 -----SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ-QDALWTEKL-QVLKQQYQ 639
Query: 708 VGKENMQ 714
E ++
Sbjct: 640 TEMEKLR 646
Score = 56.8 bits (131), Expect = 3e-07
Identities = 94/505 (18%), Positives = 209/505 (41%), Gaps = 33/505 (6%)
Query: 11 LVAQKNQKKTNVHKKLDSESTKINTKTSSSLCKSR--SNTLNSIRPVDGXXXXXXXXXXX 68
L++Q +K+ K +S +++NTK + L S+
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 69 XLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIE 128
+ + + ++ ++ + + +++L+Q E K++T+ + +
Sbjct: 1715 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE---KEETVSSHFEMRC 1771
Query: 129 DYKNEIAQLQEI-LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
Y+ + +L+ K+ + H + E ++K S + + N +Q +
Sbjct: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK--Q 1829
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYD------KQMELSSLE-EVITVRDSLCKDLQE 240
+ + +D++ + E E C+ L+ ++ + +Q E+ +E E +T + + LQ+
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ 1889
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI---IS 297
N+ T + E K H + + ++ ++ +LE + EKQ + I
Sbjct: 1890 MDGRNKPTELLEENTEEKSKSH-LVQPKLLSNMEAQHN-DLEFKLAGAEREKQKLGKEIV 1947
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ + D L+ +H +E LK + +E+ E ++Q L +K + L+Q+ + +
Sbjct: 1948 RLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN---STLKQLMREFNTQ 2004
Query: 358 LKICEIQFEERSQSIQEHCSQ-QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
L E +E +I+E ++ QE + LE +E L ++ DLK+ +
Sbjct: 2005 LAQKE---QELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEK-TINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
D E + +++T +EL +K E E+N N V I E +T L+
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV--TIME---LQTQLAQKT 2116
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQ 500
++ L+ +E ++ LED+++
Sbjct: 2117 TLISDSKLKEQEFREQIHNLEDRLK 2141
>X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein.
Length = 3259
Score = 87.0 bits (206), Expect = 2e-16
Identities = 101/487 (20%), Positives = 222/487 (45%), Gaps = 21/487 (4%)
Query: 108 AQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKL 167
++D ++ + Q+++ + E +L+ LK +T + + + ++ +++K
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELE--LKVSSTTSELTKKSEEVFQLQEQINKQ 1349
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
+ + T + + AE + + + +I LE E L ++ + Q +S EE
Sbjct: 1350 GLEIESLKTVSHEAE-VHAESLQQKLESSQLQIAGLEHLRE-LQPKLDELQKLISKKEED 1407
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK 287
++ + + LT + + E + ++ + H L ++A E R ++++E + K
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL--HTQLEMQAKEHDERIKQLQVELCEMK 1465
Query: 288 LDEEKQAIISKCKVD-QENLKTKHNASIESLK-NQMLKEKCE----ALEQLHSQLIIKEQ 341
E+ S+ K Q L+ + E+LK N+ L+E+ +E+L L E
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ A+ ++ +++ +L + + EER + I E + Q L + LK L+
Sbjct: 1526 QVSAQNKE-KDTVLGRLALLQ---EERDKLITE-MDRSLLENQSLSSSCESLKLALEGLT 1580
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
L +E+ +LK+ K STE +E++ + L++ N NE ++ VE
Sbjct: 1581 EDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR 1640
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
+EK + L T +L+E++ E+E+++++++ +K+ EL + L
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLR 1700
Query: 522 NTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV--EKEAY-RELGTIK 577
V D KE + +L S A++ +E R+ TL + Q++ EK++ E+ +K
Sbjct: 1701 AEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLK 1760
Query: 578 NELIEDV 584
+++ ++V
Sbjct: 1761 HQIEDNV 1767
Score = 82.6 bits (195), Expect = 4e-15
Identities = 114/562 (20%), Positives = 262/562 (46%), Gaps = 46/562 (8%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYN---KQIEDYKNEIAQLQ 138
K N +TL KN +L Q + +D E++ + + + N +QI++ + + +L+
Sbjct: 1856 KQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK 1912
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
E +E + N E++ + + T+ ++ ++ ++ + + ++++
Sbjct: 1913 ETAEEEKDDLEERLMN-QLAELNGSIGNYCQDVTDAQIKNELLE-SEMKNLKKCVSELEE 1970
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LE 257
+L K+ +++E+ + +E + S K+LQE L + + + Q+ +
Sbjct: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
Query: 258 MVKGHHAL--ALEANESIRREYKIELEALKTKLDE------EKQAIISKCKVDQENLKTK 309
+ AL ++A E ++ E + +LE K L + + QA ++ KV ++ T+
Sbjct: 2031 YQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD--TQ 2088
Query: 310 HNASIESLKNQMLKEKCEA-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
A+ N LK++ ++ E + SQ+ K+++++ +LEQ EE ++ K + + +
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL 2148
Query: 369 SQS---IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE- 424
+ ++E + + T+ ++E+++L+ LD T Q + + +++L++ +D + E
Sbjct: 2149 RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEA 2208
Query: 425 -----KFNFI-----EEIK-------TLKDELIEKTINYENEK-NKLNLAVEKAIKEKNK 466
KF+ EEI+ LKD+L + +I+ E K N L +K I E +K
Sbjct: 2209 KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWE-SK 2267
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL---NNT 523
+T + + + + L +E S+LE+ + LE+EL + K+ L +N+
Sbjct: 2268 AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2327
Query: 524 VRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
+ +C E K L I++ + A + E T +++ + + + E+ + ++I
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL 2387
Query: 584 VELLKKESNSQIKFLREEVEKK 605
+ ++ I LR++ +K+
Sbjct: 2388 LSGKEEAIQVAIAELRQQHDKE 2409
Score = 79.0 bits (186), Expect = 5e-14
Identities = 95/486 (19%), Positives = 213/486 (43%), Gaps = 49/486 (10%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+ ++ RI LE++ + + E ++L I+ +D K LQE++T L +
Sbjct: 1842 IDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI 1901
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK------CKVDQENL 306
Q+ L V A E + + +L L + Q + + + +NL
Sbjct: 1902 QEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNL 1961
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
K K + +E K Q++KEK + ++ + + K Q A+ E +S +++L+ + +
Sbjct: 1962 K-KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG--AQKEPGNKSHAKELQELLKEKQ 2018
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYT-------LDLTNNQ-------NSDLKQELN 412
+ + +Q+ C + ++ I LE+ +K L++ L++T + EL
Sbjct: 2019 QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELA 2078
Query: 413 NLKNCKDELSTEKFNFIEEIKTLKDEL------IEKTINYENE--KNKLNLAVEKAIKEK 464
+ K D+ +E + + LK EL ++ + ++E + +L A EK +KEK
Sbjct: 2079 SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK 2138
Query: 465 NKFETSL-SVTRDIVHV------LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK 517
+ L ++ R+ VH+ + + L + D E++QL++ + + +++ +
Sbjct: 2139 KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQ 2198
Query: 518 NTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK 577
+ + + E +++ + ++SK +E R+ E N +++ K+ R++
Sbjct: 2199 DDRDRVIDEAKKWERKFSDAIQSK----EEEIRLKEDNCSVL-------KDQLRQMSIHM 2247
Query: 578 NELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADL 637
EL ++ L+ + + EV+ ++ +C+ +R L + +L
Sbjct: 2248 EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL 2307
Query: 638 SRLENE 643
++LE+E
Sbjct: 2308 AKLESE 2313
Score = 66.9 bits (156), Expect = 2e-10
Identities = 99/503 (19%), Positives = 211/503 (41%), Gaps = 35/503 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
EI N +Q I E+ K ++ + L E +L ++ ++ E+ ++ +L +N
Sbjct: 717 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM---VTELRAQVKQLEMNL 773
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
+ D E +A N + +I L + ++ D ++ Q EL ++ + +
Sbjct: 774 AEAERQRRL----DYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ 829
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEE 291
+L + LQ +L + E + E +R+ H + +E + ++E+ + L E+
Sbjct: 830 STLIRSLQSQLQNKESEVLEGAERVR----HISSKVEELSQALSQKELEITKMDQLLLEK 885
Query: 292 KQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAK 346
K+ + + + +++ T+ + S+ Q+ +EK ++ L QL + + +AK
Sbjct: 886 KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAK 945
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD 406
EQ+EE E S ++++ + Q ++E L++ DL +N
Sbjct: 946 KEQVEED------------NEVSSGLKQNYDEMSPAGQISKEE---LQHEFDLLKKENEQ 990
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
K++L + EL EE+ LKDE ++ E E+ ++ +K KE ++
Sbjct: 991 RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE--EDKENKEYSE 1048
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE 526
+ S ++I L + E + EL+ + ++ +A+E + + TL + +
Sbjct: 1049 -KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQ 1107
Query: 527 CDEYK-EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
D + E N + +T +V L++ + K EL E +
Sbjct: 1108 IDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKIL 1167
Query: 586 LLKKESNSQIKFLREEVEKKRVL 608
L+KE K L+E + ++ +
Sbjct: 1168 ALEKEKEQLQKKLQEALTSRKAI 1190
Score = 61.7 bits (143), Expect = 9e-09
Identities = 110/559 (19%), Positives = 250/559 (44%), Gaps = 64/559 (11%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEI-----AQLQEILK 142
+++ L + ++ ++++ +DV+++ KD+ + E K ++ ++ A+L + K
Sbjct: 50 VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK 109
Query: 143 ELATKFRQSHNNIDFN-EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q + + + +LSK ++T E ++ EK +I+ +++++
Sbjct: 110 YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK-EELISTLQAQLT 168
Query: 202 ELEKKCEALDN----EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
+ + + A + E + +L EE I+ + Q + + ++ + E R E
Sbjct: 169 QAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQV-VREKDARFE 227
Query: 258 -MVKGH--HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
V+ H L L + E + +L L+ KL+E +++++ + +V + L+ + A+
Sbjct: 228 TQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV-VDLLQQELTAAE 286
Query: 315 ESLKNQMLKEKCEALEQLHSQL----IIKEQEMKAKLEQIE-ESASEKLKICEI------ 363
+ +NQ+L ++ + +E H+ L + +E K LE++E E A KL +
Sbjct: 287 Q--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH 344
Query: 364 ---QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
QFE+ Q+ E S+ Q + E++E + +L+ + LK+ +
Sbjct: 345 LLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSK 404
Query: 421 LSTEK----FNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN----KFETSLS 472
L +K + I+ L+D+L +K+ N+L L + + + E + +
Sbjct: 405 LLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464
Query: 473 VTRDIVHVLTLRLRESDSELEQL---EDQVQMLTSAKEVLENELTTY--KNTLNNTVREC 527
VT + + L R+ E ++E L +++ L + E L +++T +N RE
Sbjct: 465 VTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREV 524
Query: 528 DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELL 587
E ++V+I +++ +E + + L+N + ++EL + E+
Sbjct: 525 SEI--SIVDIANKRSSSAEESGQ---------DVLENTFSQKHKELSVLLLEM------- 566
Query: 588 KKESNSQIKFLREEVEKKR 606
KE+ +I FL+ +++ KR
Sbjct: 567 -KEAQEEIAFLKLQLQGKR 584
Score = 60.9 bits (141), Expect = 2e-08
Identities = 114/592 (19%), Positives = 238/592 (40%), Gaps = 54/592 (9%)
Query: 119 TICEYNKQIEDYKNEI-AQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNC 174
TI K + D ++++ AQ +E +L LA Q + E+DR L + + +++C
Sbjct: 1512 TIERLTKSLADVESQVSAQNKEKDTVLGRLA--LLQEERDKLITEMDRSLLENQSLSSSC 1569
Query: 175 HTEHNAVQGT--DAEKVSAMINDMRSRII-----------ELEKKCEALDNEVYDKQMEL 221
+ A++G D EK+ I ++S I EL+K+ E L + E
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1629
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
++ V+ ++L KL S E ET+++L+ + E E +R+ K +
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME---EMKEKMRKFAKSKQ 1686
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ + +L+EE + ++ + K + S N +KE+ E ++ + L K Q
Sbjct: 1687 QKI-LELEEENDRLRAEVHPAGDTAKECMETLLSS--NASMKEELERVKMEYETLSKKFQ 1743
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERS--QSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
+ ++ + + E + E +++ ++ ++H +Q T + + E + L
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL 1803
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK---DELIEKTINYENEKNKLNLA 456
+ + + + + K+ +S + F+ +EI D+L E+ E EK K
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKD-FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF 1862
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
+ EKN + +S D EL+ L+++V + + ++ EL+
Sbjct: 1863 SQTLENEKNTLLSQIST--------------KDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
E D+ +E L+N L + + +VT + + + + L
Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ----DVTDAQIKNELLESEMKNLKKC 1964
Query: 577 KNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAAD 636
+EL E+ + L KE + E+ K+ + + LL + +
Sbjct: 1965 VSELEEEKQQLVKEKTK----VESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
Query: 637 LSRLENENERYXXXXXXXXSLVVELSLLRQENE-ELTMTVAKQSSIIDKLKK 687
+ +L+ + RY V L ++ E++ +L +T + ++ KK
Sbjct: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072
Score = 59.3 bits (137), Expect = 5e-08
Identities = 98/462 (21%), Positives = 188/462 (40%), Gaps = 38/462 (8%)
Query: 131 KNEIAQLQEILKELATKFRQSHNN-IDFNE----IDRKLSKLRINNTNCH-----TEHNA 180
K+ +LQE+LKE + +Q + I + E ++R + L T T+ N
Sbjct: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL 2063
Query: 181 VQGTD-AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q + +K A + + + + + + + + + EL S +E + S K
Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK---SQMKQKD 2120
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI-ELEALKTKLDEEKQAIISK 298
E L L AE + E L E + E I E++ K D+E Q +
Sbjct: 2121 EDL-ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQEN 2179
Query: 299 CK--VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE 356
V Q TK +S++ +++++ E + + + KE+E++ K + +
Sbjct: 2180 LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV-LKD 2238
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
+L+ I EE +I ++ + E++ + D +N +L +L ++
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLN--LAVEKAIKEKNKF---- 467
E E+K+LKD+L + + + E +K L + ++A + +KF
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ 2358
Query: 468 -ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE 526
ET L +R+ LT RL E E+ E ++ L S KE E +E
Sbjct: 2359 LETDLQASRE----LTSRLHE---EINMKEQKIISLLSGKE--EAIQVAIAELRQQHDKE 2409
Query: 527 CDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
E + L + L +E+ + ++ L+E+L+ ++KE
Sbjct: 2410 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
Score = 58.8 bits (136), Expect = 6e-08
Identities = 94/488 (19%), Positives = 203/488 (41%), Gaps = 41/488 (8%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q+EL + + E+++ + + + +E K + L+ I+++ + S + +++
Sbjct: 2304 QNELAKLES-ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS--KFSYEQLE 2360
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
L R + H E N + +S ++ I EL ++ D E+ + + L
Sbjct: 2361 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH---DKEIKELENLL 2417
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S EE V + K +K TL ++ K +++ S++ + + +
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND-RDRI 2476
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+L+E +II ++++ L + A +N LKE+ L L +
Sbjct: 2477 VGDYQQLEERHLSII----LEKDQLIQEAAA-----ENNKLKEEIRGLRSHMDDLNSENA 2527
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ A+L Q E ++ + I+ ++ Q ++ Q ++ LE + +L+ L +
Sbjct: 2528 KLDAELIQYREDLNQ---VITIKDSQQKQLLEVQLQQNKE----LENKYAKLEEKLKESE 2580
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN------KLNL 455
N DL++ N L+ K +LS E IE +K +L + + E +L +
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKE----IESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2636
Query: 456 AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED----QVQMLTSAKEVLEN 511
E+ + F +S ++ L +E+ ++ ++ED +++ L ++ N
Sbjct: 2637 KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN 2696
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
E T + + R+ E ++ L+ + K LT + ++ + SLQN A
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQ----IQSFGRSMSSLQNSRDHANE 2752
Query: 572 ELGTIKNE 579
EL +K +
Sbjct: 2753 ELDELKRK 2760
Score = 56.8 bits (131), Expect = 3e-07
Identities = 106/535 (19%), Positives = 221/535 (41%), Gaps = 41/535 (7%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EI 140
KA ++ T + ++ D+ +++EI + E + I + ++ Q Q E
Sbjct: 115 KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
Query: 141 LKELATKFRQS-HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR-- 197
+ +T+ + E + +S L+ + E A Q EK + +R
Sbjct: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ-AAQQVVREKDARFETQVRLH 233
Query: 198 -SRIIELEKKCEALDNEVYDK----QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+++L + + ++ E+ K Q +L EE + R + LQ++LT+ E
Sbjct: 234 EDELLQLVTQAD-VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQIL 292
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q+L+ ++ H E+ R E KI LE ++ ++ E K + + + +L +
Sbjct: 293 SQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSF-HNLQEEMHHLLEQFEQ 351
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
+ ++ L+ + ALEQ H + +E + + ++++ E C+ ++ S+ +
Sbjct: 352 AGQAQAE--LESRYSALEQKHKA---EMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406
Query: 373 Q---EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
Q E Q +TIQ LE ++++ + N+ L+Q + ++ E +
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR-LPLQQHETASQTSFPDVYNEGTQAV 465
Query: 430 EEIKTLKDELIEKTINYENEKNKL---NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E L ++ + ENEK L ++ +E+ E K + +++ R
Sbjct: 466 TEENIA--SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE-----AQNRTG 518
Query: 487 ESDSELEQLE--DQVQMLTSAKEVLENELTTYKNTLNNTVRECD----EYKEALVNILKS 540
E+D E+ ++ D +S+ E E+ +NT + +E E KEA I
Sbjct: 519 EADREVSEISIVDIANKRSSSAE--ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL 576
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKESNS 593
K L + +H V + ++ +E E A ++ + +D L+ E +S
Sbjct: 577 KLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Score = 55.2 bits (127), Expect = 8e-07
Identities = 117/616 (18%), Positives = 246/616 (39%), Gaps = 33/616 (5%)
Query: 86 SSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE- 143
SSI+ + L K+ Q L++AQ+ D+ + E + I D N+ + E +
Sbjct: 490 SSIELEELKAENEKLSSQITLLEAQN-RTGEADREVSEIS--IVDIANKRSSSAEESGQD 546
Query: 144 -LATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM-INDMRSRII 201
L F Q H + ++ K ++ I + + D E + + M I
Sbjct: 547 VLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 606
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
K L++ D + + + V + TS E++L + L+ K
Sbjct: 607 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQ 666
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
+L A I + ++ ELE LK+++ E + ++ ++NL K I +L NQ+
Sbjct: 667 DGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAK-EISNL-NQL 724
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEE-----SASEKLKICEIQFEERSQSIQEHC 376
++E + + S +E L Q++E ++K E+ E + +
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q L ++I L + + L+ EL++++ E ST + +++ +
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
E++E + +K+ + +A+ +K L +T+ + +L + R+ ++ + +E
Sbjct: 845 SEVLEGAERVRHISSKVE-ELSQALSQK-----ELEITK-MDQLLLEKKRDVETLQQTIE 897
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
++ Q +T + ++ + E KE L N+L KE ++ E N
Sbjct: 898 EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAKKE--QVEEDNE 954
Query: 557 TLIESLQNVEKEAYRELGTI-KNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXX 615
QN ++ + G I K EL + +LLKKE+ + + L+ + ++ L +
Sbjct: 955 VSSGLKQNYDEMS--PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL 1012
Query: 616 XXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
S+ + + + +E + E S E+ + L T+
Sbjct: 1013 EEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY------LKQTI 1066
Query: 676 AKQSSIIDKLKKDLEQ 691
+++ + ++KDLE+
Sbjct: 1067 SEKEVELQHIRKDLEE 1082
Score = 54.0 bits (124), Expect = 2e-06
Identities = 97/528 (18%), Positives = 219/528 (41%), Gaps = 47/528 (8%)
Query: 104 ELVQAQDVEIRNK----DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE 159
E+ Q+ E+ NK ++ + E + ED + LQE ++L+ + + ++
Sbjct: 2556 EVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL--KVSISQ 2613
Query: 160 IDRKLSKLRINNT-NCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNE----- 213
+ R+++ L+ T + V+ + ++SA+ + + RI ELE++ + E
Sbjct: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
Query: 214 --VYDK-QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV----KGHHAL- 265
+ DK + EL L + + + +E++ L E +Q+L MV KG A
Sbjct: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQI 2733
Query: 266 -----ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK-- 318
++ + ++ R EL+ LK K D + + ++ K +Q L + +A +
Sbjct: 2734 QSFGRSMSSLQNSRDHANEELDELKRKYDASLKEL-AQLK-EQGLLNRERDALLSETAFS 2791
Query: 319 -NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE----KLKICEIQFE------- 366
N + LE+L+ QL+ K++++ Q+E+S ++ + +Q E
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
E+ + +E + E++ LK + N L +EL NL+ +++ E
Sbjct: 2852 LEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE- 2910
Query: 426 FNFIEEIKTLKDELIEKTINY---ENEKNKLNLAVEKAIKEKNKFETSLSV-TRDIVHVL 481
+ +K E +KT + + E + NL+ + + + ++S + R +
Sbjct: 2911 ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY 2970
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ + + D +L L++ ++ L S+ + Y+ + + + LV +
Sbjct: 2971 LMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL 3030
Query: 542 AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKK 589
+ + + I+ L + + E T+ +L + + L++
Sbjct: 3031 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRE 3078
Score = 48.0 bits (109), Expect = 1e-04
Identities = 112/503 (22%), Positives = 205/503 (40%), Gaps = 43/503 (8%)
Query: 206 KCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV--KGHH 263
KC+ + E+Y KQ E+ +R KDL+EKL + E A +Q + + K +
Sbjct: 1054 KCQEI--EIYLKQTISEKEVELQHIR----KDLEEKLAAEEQFQALVKQMNQTLQDKTNQ 1107
Query: 264 ALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
L+A S + +L T D + A++ + V + S E K + L
Sbjct: 1108 IDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVV----ISPPCTGSSEHWKPE-L 1162
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS---IQEHCSQQ 379
+EK ALE+ QL K QE + I + A EK + + +++ +QE +Q
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK--FNFIEEIKT--- 434
K + + ++++L+ + + + + L + ++C E+ F E+ T
Sbjct: 1223 SKENENIGDQLRQLQ--IQVRESIDGKL-PSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 435 LKDELIEKTINYENEKNKLNLAVEKA-IKEKNKFETSLSVTRDI-VHVLTLRLRESDSEL 492
L+ L ++ + + L A IK + K + V ++ V T L + E+
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
Query: 493 EQLEDQVQ---MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHT 549
QL++Q+ + + + + +E + +L + E + + A + L+ E
Sbjct: 1340 FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL-ESSQLQIAGLEHLRELQPKLDELQ 1398
Query: 550 RIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK---KESNSQIKFLREEVEKKR 606
+++ + L E L I+ E+IE +L+K + Q K E +++ +
Sbjct: 1399 KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 607 V-LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR 665
V LCEM ++ AA +SR E E SL ELSL R
Sbjct: 1459 VELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN--------KSLQEELSLAR 1510
Query: 666 QENEELTMTVAKQSSIIDKLKKD 688
E LT ++A S + K+
Sbjct: 1511 GTIERLTKSLADVESQVSAQNKE 1533
>U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein.
Length = 2230
Score = 87.0 bits (206), Expect = 2e-16
Identities = 122/544 (22%), Positives = 255/544 (46%), Gaps = 51/544 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK---ELATKFRQSH 152
K K+ ++ D E ++ + + NK +ED E +L E L ++ K ++
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
Query: 153 NNIDFNE-IDRKLSKLR-INNTNCHTEHNAVQGTDAEKV-SAMINDMRSRIIELEKKCEA 209
NE I+ SK I + H +H + +A + + ++++ +++ +L ++
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 210 LD-------NEVYDKQMELSSL----EEVITVRDSLCKDL-QEKLTSNELTLAETQQRLE 257
L+ +++ +K+ ++ S+ E ++T +++L K+ ++ ++E TQ + E
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
+ + +A+ L E +E K+E+ +L +L + + + + ++ A+I SL
Sbjct: 1348 LSENINAVTLMKEEL--KEKKVEISSLSKQLTDLNVQLQNSISLSEKE------AAISSL 1399
Query: 318 KNQMLKEKCEALEQ---LHSQLIIKEQEMKAKLEQIEE---SASEKLKICEIQFEERSQS 371
+ Q +EKCE L+Q L ++ +E + LEQ+++ SE K + +F + +
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
Query: 372 IQEHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCKDELSTE 424
++E Q E K +++I LK LD N + LK E+ + ++ + L TE
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
+ I L+D + +KTI E+ L N +K I+ K + L +++
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ-KLQHFQELGEEKDN 1578
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK-A 542
R++E++ ++ LE+QV + + E + EL +N +V+ +E +AL + L+S+ A
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKEL----EHVNLSVKSKEEELKALEDRLESESA 1634
Query: 543 ALTKEHTRIMEHNVTLIES---LQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
A E R E + I+ Q EKE + GT + + ++ +E ++ L
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH--LSELNTKLQEREREVHILE 1692
Query: 600 EEVE 603
E+++
Sbjct: 1693 EKLK 1696
Score = 80.2 bits (189), Expect = 2e-14
Identities = 120/653 (18%), Positives = 285/653 (43%), Gaps = 58/653 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ-L 137
K +A ++K L+ + + +L D +I+ ++T E ++ + + Q +
Sbjct: 407 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+++K+ + + + E+ RK +L T Q E++ + +
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQEL---TKKLQTREREFQ----EQMKVALEKSQ 519
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
S +++ ++ E ++ + ++EL + ++T ++ +DLQ++ + + E + LE
Sbjct: 520 SEYLKISQEKEQQESLALE-ELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLE 577
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
+L+ N++ ++ + LEA K K ++E ++ K H +ESL
Sbjct: 578 K-------SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK-----------HKTELESL 619
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES-ASEKLKICEIQFEERSQSIQEHC 376
K+Q E L+ L Q + ++++ K EQ +E+ +K I + EE ++ E
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKT- 434
++ ++ L E+ E+ + S LK + + +K + ++ +K + +++ +
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+K+ + + K+++N +E +KE++K L + V L ++ S+ EL+Q
Sbjct: 740 IKEHEVSIQRTEKALKDQIN-QLELLLKERDK---HLKEHQAHVENLEADIKRSEGELQQ 795
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEH----TR 550
++ + S + + Y+ L ++ + + + + K A + + T
Sbjct: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 551 IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK-KRVLC 609
+ H + + + +Q +EK+ +E+ + V+ L + S+++ +E E+ K++L
Sbjct: 856 LDAHKIQVQDLMQQLEKQ--------NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 907
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E +L + +A + NE Y ++ ++Q+ +
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK---KMEKVKQKAK 964
Query: 670 ELTMTVAKQSSIID---KLKKDLEQS--QYTPKSPSVLRKSLKVGKENMQTIS 717
E+ T+ K+ ++D KLKK+LE + + + K K L++ + N IS
Sbjct: 965 EMQETLKKK--LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
Score = 69.3 bits (162), Expect = 4e-11
Identities = 125/610 (20%), Positives = 255/610 (41%), Gaps = 55/610 (9%)
Query: 119 TICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINNTNCHT 176
T+ E Q+E E + E + L + Q + D E++ SK+ +N T
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-------LSSLEEVIT 229
E + ++ + + + + IE+E E L N K +E L +E+
Sbjct: 1519 ELKS----QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 230 VRDSLCKDLQEKLTSNELTLAETQQRLEMVKG---HHALALEANES--------IRREYK 278
+D+ K+ +EK+ + E + + LE K H L++++ E + E
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
Query: 279 IELEALKTKLDEE----KQAIISKCKVDQENLKTKHNASIESLKNQM---------LKEK 325
+L LK K +++ K+ ++S+ + +E K + + L ++ L+EK
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+++E S+ +I + K E+ ++ + +EE+ +Q + +++EK +Q
Sbjct: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR 1754
Query: 386 LEQEIKE-LKYTLDL-TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ QE +E + ++ Q +K E K +D+ E K K LI
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQ 1814
Query: 444 INYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIVHVLTLRLRESDSELEQLED----Q 498
+ E E K N+ ++ ++ + + +L +L +++E DS L + ++ +
Sbjct: 1815 -HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE 1873
Query: 499 VQMLTSAKEVLEN-ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
++ LTS E L+ + +N + E E K + ++++ K E +HN
Sbjct: 1874 MEELTSKYEKLQALQQMDGRNKPTELLEENTEEK-SKSHLVQPKLLSNME----AQHN-D 1927
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
L L E+E ++LG L +D+ +L+KE +++ L++E +++R ++
Sbjct: 1928 LEFKLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQED 1985
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
+ L+ + L++ E E E + VE LL EE + K
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELE-MTIKETINKAQEVEAELLESHQEETNQLLKK 2044
Query: 678 QSSIIDKLKK 687
+ D LK+
Sbjct: 2045 IAEKDDDLKR 2054
Score = 68.9 bits (161), Expect = 6e-11
Identities = 102/564 (18%), Positives = 239/564 (42%), Gaps = 49/564 (8%)
Query: 80 ITKAPNSSIKKTLTCPKNKILPQ-DELVQAQDVEIRNKDQTICEYNKQI-------EDYK 131
+T+ + ++ + K+ Q +EL + +++++ K+Q + E ++I E+
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 1091
Query: 132 NEIAQLQE-------ILKELATKFRQSHNNI-----DFNEIDRKLSKLRINNTNCHTEHN 179
EI L+E L EL + +Q ++ D ++ L KL ++ E+
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
+Q E + + + + ++ EL K + D E + + + + K L
Sbjct: 1152 FLQEQLVE-LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLS 1210
Query: 240 EKLTSN-ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
E+L ++ +T+ LE K + + + ++++ + + + + K+A++ K
Sbjct: 1211 EELAIQLDICCKKTEALLE-AKTNELINISSSKT--NAILSRISHCQHRTTKVKEALLIK 1267
Query: 299 -CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQI--EESAS 355
C V + + + ++ N ++ LE+ +Q+ + MKA +E + E+ A
Sbjct: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI----KSMKADIESLVTEKEAL 1323
Query: 356 EKLKICEIQFEERSQS----IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL 411
+K + Q +S +++ S+ + +++E+KE K + + Q +DL +L
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 412 NN---LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKF- 467
N L + +S+ + + EE L D++ + + + + A+E+ NKF
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 468 ------ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
++ + ++ V L ++L E + ++Q+ +L + K +
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ + ++ + L LKS+ A E + IESL V K ++ EL+
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 582 EDV---ELLKKESNSQIKFLREEV 602
+ + + L +E ++++K E++
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKI 1587
Score = 58.0 bits (134), Expect = 1e-07
Identities = 109/547 (19%), Positives = 235/547 (42%), Gaps = 53/547 (9%)
Query: 202 ELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+++ + E L +++ +K+ + L + S E +T+ ++ E ++ ++
Sbjct: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
+L +R E +++ +A K L EE A + + L+T+ + + L+N
Sbjct: 179 SQSQDKSLRRIAELREELQMDQQA-KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 320 -QMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESAS---------EKLKICEIQFEE 367
M + + L QL Q + KE+ ++ E + E + +++K E +
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
Query: 368 RSQSIQEH---C----SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++IQ H C S++E + L++ ++EL+ DL + + L +L + KN ++
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 421 LSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
L +K I E K E + E+ + ++ E+ ++K K E + +
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 477 IVHVLTLRLRESDSELE-QLEDQVQML--TSAKE--VLENELTTYKNTLNNTVRECDEYK 531
+ E+ +L+ ++++Q++ + TS +E L+ EL+ K + + +++ E +
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
A + L K KE L + LQ E+E ++ + + + +E
Sbjct: 478 IAKLQKLHEKELARKEQ--------ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 592 NSQIKFLREEVE--KKRVLCEM-XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYX 648
Q EE+E KK +L E +R+L +++ + S EN+N+
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ--- 586
Query: 649 XXXXXXXSLVVELSLLR-QENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
L V L + + N+E+T+ V K + ++ LK + + +T K VL++ +
Sbjct: 587 -----SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ-QDALWTEKL-QVLKQQYQ 639
Query: 708 VGKENMQ 714
E ++
Sbjct: 640 TEMEKLR 646
Score = 56.8 bits (131), Expect = 3e-07
Identities = 94/505 (18%), Positives = 209/505 (41%), Gaps = 33/505 (6%)
Query: 11 LVAQKNQKKTNVHKKLDSESTKINTKTSSSLCKSR--SNTLNSIRPVDGXXXXXXXXXXX 68
L++Q +K+ K +S +++NTK + L S+
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 69 XLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIE 128
+ + + ++ ++ + + +++L+Q E K++T+ + +
Sbjct: 1715 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE---KEETVSSHFEMRC 1771
Query: 129 DYKNEIAQLQEI-LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
Y+ + +L+ K+ + H + E ++K S + + N +Q +
Sbjct: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK--Q 1829
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYD------KQMELSSLE-EVITVRDSLCKDLQE 240
+ + +D++ + E E C+ L+ ++ + +Q E+ +E E +T + + LQ+
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ 1889
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI---IS 297
N+ T + E K H + + ++ ++ +LE + EKQ + I
Sbjct: 1890 MDGRNKPTELLEENTEEKSKSH-LVQPKLLSNMEAQHN-DLEFKLAGAEREKQKLGKEIV 1947
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ + D L+ +H +E LK + +E+ E ++Q L +K + L+Q+ + +
Sbjct: 1948 RLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN---STLKQLMREFNTQ 2004
Query: 358 LKICEIQFEERSQSIQEHCSQ-QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
L E +E +I+E ++ QE + LE +E L ++ DLK+ +
Sbjct: 2005 LAQKE---QELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEK-TINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
D E + +++T +EL +K E E+N N V I E +T L+
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV--TIME---LQTQLAQKT 2116
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQ 500
++ L+ +E ++ LED+++
Sbjct: 2117 TLISDSKLKEQEFREQIHNLEDRLK 2141
>D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 protein.
Length = 3225
Score = 86.6 bits (205), Expect = 3e-16
Identities = 103/495 (20%), Positives = 220/495 (44%), Gaps = 26/495 (5%)
Query: 108 AQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKL 167
++D ++ + Q+++ + E +L+ LK +T + + + ++ +++K
Sbjct: 1258 SEDASALQGGTSVAQIKAQLKEIEAEKVELE--LKVSSTTSELTKKSEEVFQLQEQINKQ 1315
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
+ + T + + AE + + + +I LE E L ++ + Q +S EE
Sbjct: 1316 GLEIESLKTVSHEAE-VHAESLQQKLESSQLQIAGLEHLRE-LQPKLDELQKLISKKEED 1373
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK 287
++ + + LT + + E + ++ + H L ++A E R ++++E + K
Sbjct: 1374 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL--HTQLEMQAKEHDERIKQLQVELCEMK 1431
Query: 288 LDEEKQAIISKCKVD-QENLKTKHNASIESLK-NQMLKEKCE----ALEQLHSQLIIKEQ 341
E+ S+ K Q L+ + E+LK N+ L+E+ +E+L L E
Sbjct: 1432 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1491
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ A+ ++ +++ +L + + EER + I E + Q L + LK L+
Sbjct: 1492 QVSAQNKE-KDTVLGRLALLQ---EERDKLITE-MDRSLLENQSLSSSCESLKLALEGLT 1546
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
L +E+ +LK+ K STE +E++ + L++ N NE ++ VE
Sbjct: 1547 EDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR 1606
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
+EK + L T +L+E++ E+E+++++++ +K+ EL + L
Sbjct: 1607 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLR 1666
Query: 522 NTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
V D KE + +L S A++ +E R+ TL + Q++ E K+ L
Sbjct: 1667 AEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE--------KDSL 1718
Query: 581 IEDVELLKKESNSQI 595
E+V+ LK + +
Sbjct: 1719 SEEVQDLKHQIEGNV 1733
Score = 82.6 bits (195), Expect = 4e-15
Identities = 114/562 (20%), Positives = 262/562 (46%), Gaps = 46/562 (8%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYN---KQIEDYKNEIAQLQ 138
K N +TL KN +L Q + +D E++ + + + N +QI++ + + +L+
Sbjct: 1822 KQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK 1878
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
E +E + N E++ + + T+ ++ ++ ++ + + ++++
Sbjct: 1879 ETAEEEKDDLEERLMN-QLAELNGSIGNYCQDVTDAQIKNELLE-SEMKNLKKCVSELEE 1936
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LE 257
+L K+ +++E+ + +E + S K+LQE L + + + Q+ +
Sbjct: 1937 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 1996
Query: 258 MVKGHHAL--ALEANESIRREYKIELEALKTKLDE------EKQAIISKCKVDQENLKTK 309
+ AL ++A E ++ E + +LE K L + + QA ++ KV ++ T+
Sbjct: 1997 YQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD--TQ 2054
Query: 310 HNASIESLKNQMLKEKCEA-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
A+ N LK++ ++ E + SQ+ K+++++ +LEQ EE ++ K + + +
Sbjct: 2055 SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL 2114
Query: 369 SQS---IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE- 424
+ ++E + + T+ ++E+++L+ LD T Q + + +++L++ +D + E
Sbjct: 2115 RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEA 2174
Query: 425 -----KFNFI-----EEIK-------TLKDELIEKTINYENEK-NKLNLAVEKAIKEKNK 466
KF+ EEI+ LKD+L + +I+ E K N L +K I E +K
Sbjct: 2175 KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWE-SK 2233
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL---NNT 523
+T + + + + L +E S+LE+ + LE+EL + K+ L +N+
Sbjct: 2234 AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2293
Query: 524 VRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
+ +C E K L I++ + A + E T +++ + + + E+ + ++I
Sbjct: 2294 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL 2353
Query: 584 VELLKKESNSQIKFLREEVEKK 605
+ ++ I LR++ +K+
Sbjct: 2354 LSGKEEAIQVAIAELRQQHDKE 2375
Score = 79.0 bits (186), Expect = 5e-14
Identities = 95/486 (19%), Positives = 213/486 (43%), Gaps = 49/486 (10%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+ ++ RI LE++ + + E ++L I+ +D K LQE++T L +
Sbjct: 1808 IDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI 1867
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK------CKVDQENL 306
Q+ L V A E + + +L L + Q + + + +NL
Sbjct: 1868 QEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNL 1927
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
K K + +E K Q++KEK + ++ + + K Q A+ E +S +++L+ + +
Sbjct: 1928 K-KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG--AQKEPGNKSHAKELQELLKEKQ 1984
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYT-------LDLTNNQ-------NSDLKQELN 412
+ + +Q+ C + ++ I LE+ +K L++ L++T + EL
Sbjct: 1985 QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELA 2044
Query: 413 NLKNCKDELSTEKFNFIEEIKTLKDEL------IEKTINYENE--KNKLNLAVEKAIKEK 464
+ K D+ +E + + LK EL ++ + ++E + +L A EK +KEK
Sbjct: 2045 SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK 2104
Query: 465 NKFETSL-SVTRDIVHV------LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK 517
+ L ++ R+ VH+ + + L + D E++QL++ + + +++ +
Sbjct: 2105 KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQ 2164
Query: 518 NTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK 577
+ + + E +++ + ++SK +E R+ E N +++ K+ R++
Sbjct: 2165 DDRDRVIDEAKKWERKFSDAIQSK----EEEIRLKEDNCSVL-------KDQLRQMSIHM 2213
Query: 578 NELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADL 637
EL ++ L+ + + EV+ ++ +C+ +R L + +L
Sbjct: 2214 EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL 2273
Query: 638 SRLENE 643
++LE+E
Sbjct: 2274 AKLESE 2279
Score = 66.9 bits (156), Expect = 2e-10
Identities = 99/503 (19%), Positives = 211/503 (41%), Gaps = 35/503 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
EI N +Q I E+ K ++ + L E +L ++ ++ E+ ++ +L +N
Sbjct: 683 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM---VTELRAQVKQLEMNL 739
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
+ D E +A N + +I L + ++ D ++ Q EL ++ + +
Sbjct: 740 AEAERQRRL----DYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ 795
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEE 291
+L + LQ +L + E + E +R+ H + +E + ++E+ + L E+
Sbjct: 796 STLIRSLQSQLQNKESEVLEGAERVR----HISSKVEELSQALSQKELEITKMDQLLLEK 851
Query: 292 KQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAK 346
K+ + + + +++ T+ + S+ Q+ +EK ++ L QL + + +AK
Sbjct: 852 KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAK 911
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD 406
EQ+EE E S ++++ + Q ++E L++ DL +N
Sbjct: 912 KEQVEED------------NEVSSGLKQNYDEMSPAGQISKEE---LQHEFDLLKKENEQ 956
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
K++L + EL EE+ LKDE ++ E E+ ++ +K KE ++
Sbjct: 957 RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE--EDKENKEYSE 1014
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE 526
+ S ++I L + E + EL+ + ++ +A+E + + TL + +
Sbjct: 1015 -KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQ 1073
Query: 527 CDEYK-EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
D + E N + +T +V L++ + K EL E +
Sbjct: 1074 IDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKIL 1133
Query: 586 LLKKESNSQIKFLREEVEKKRVL 608
L+KE K L+E + ++ +
Sbjct: 1134 ALEKEKEQLQKKLQEALTSRKAI 1156
Score = 62.1 bits (144), Expect = 7e-09
Identities = 98/517 (18%), Positives = 221/517 (42%), Gaps = 46/517 (8%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSH------NNIDFNEIDRKLS 165
++ D++ E +IE K+++ + +E++ L + Q+ ++ + E
Sbjct: 92 QLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 151
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+L+ T + T AE+ +A ++ M+ + E + + E D+ ++L +
Sbjct: 152 QLQEKEEFISTLQAQLSQTQAEQ-AAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQA 210
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK---IELE 282
+V T + LQ KL +E +L Q +++++ A + N+ + ++ + E
Sbjct: 211 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 270
Query: 283 ALKTKLD---EEKQAIISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQLHSQLI 337
L+ ++ EE + ++ K +++ K + E + + + ++ +A +L S+
Sbjct: 271 TLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYS 330
Query: 338 IKEQEMKAKLEQ-------IEESASEKLKICEIQFEERSQSIQ---EHCSQQEKTIQYLE 387
EQ+ KA++E+ ++++ E C+ ++ S+ +Q E Q +TIQ LE
Sbjct: 331 ALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE 390
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
++++ + N+ L+Q + ++ E + E L ++ + E
Sbjct: 391 DQLQQKSKEISQFLNR-LPLQQHETASQTSFPDVYNEGTQAVTEENIA--SLQKRVVELE 447
Query: 448 NEKNKL---NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE--DQVQML 502
NEK L ++ +E+ E K + +++ R E+D E+ ++ D
Sbjct: 448 NEKGALLLSSIELEELKAENEKLSSQITLLE-----AQNRTGEADREVSEISIVDIANKR 502
Query: 503 TSAKEVLENELTTYKNTLNNTVRECD----EYKEALVNILKSKAALTKEHTRIMEHNVTL 558
+S+ E E+ +NT + +E E KEA I K L + +H V
Sbjct: 503 SSSAE--ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 560
Query: 559 IESLQNVEKE--AYRELGTIKNELIEDVELLKKESNS 593
+ ++ +E E A ++ + +D L+ E +S
Sbjct: 561 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 597
Score = 61.7 bits (143), Expect = 9e-09
Identities = 114/563 (20%), Positives = 254/563 (45%), Gaps = 67/563 (11%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEI-----AQLQEILK 142
+++ L + ++ ++++ +DV+++ KD+ + E K ++ ++ A+L + K
Sbjct: 11 VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK 70
Query: 143 ELATKFRQSHNNIDFN-EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q + + + +LSK ++T E ++ EK +I+ +++++
Sbjct: 71 YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK-EELISTLQAQLT 129
Query: 202 ELEKKCEALDN----EVYDKQMELSSLEEVI-TVRDSLCKDLQE---KLTSNELTLAETQ 253
+ + + A + E + +L EE I T++ L + E +L+S + + E
Sbjct: 130 QAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQLSSMQQVVREKD 189
Query: 254 QRLE-MVKGH--HALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
R E V+ H L L + E + +L L+ KL+E +++++ + +V + L+ +
Sbjct: 190 ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV-VDLLQQEL 248
Query: 311 NASIESLKNQMLKEKCEALEQLHSQL----IIKEQEMKAKLEQIE-ESASEKLKICEI-- 363
A+ + +NQ+L ++ + +E H+ L + +E K LE++E E A KL +
Sbjct: 249 TAAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE 306
Query: 364 -------QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
QFE+ Q+ E S+ Q + E++E + +L+ + LK+
Sbjct: 307 EMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD 366
Query: 417 CKDELSTEK----FNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN----KFE 468
+L +K + I+ L+D+L +K+ N+L L + + + E
Sbjct: 367 QNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNE 426
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQL---EDQVQMLTSAKEVLENELTTY--KNTLNNT 523
+ +VT + + L R+ E ++E L +++ L + E L +++T +N
Sbjct: 427 GTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEA 486
Query: 524 VRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
RE E ++V+I +++ +E + + L+N + ++EL + E+
Sbjct: 487 DREVSEI--SIVDIANKRSSSAEESGQ---------DVLENTFSQKHKELSVLLLEM--- 532
Query: 584 VELLKKESNSQIKFLREEVEKKR 606
KE+ +I FL+ +++ KR
Sbjct: 533 -----KEAQEEIAFLKLQLQGKR 550
Score = 60.9 bits (141), Expect = 2e-08
Identities = 114/592 (19%), Positives = 237/592 (40%), Gaps = 54/592 (9%)
Query: 119 TICEYNKQIEDYKNEI-AQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNC 174
TI K + D ++++ AQ +E +L LA Q + E+DR L + + +++C
Sbjct: 1478 TIERLTKSLADVESQVSAQNKEKDTVLGRLA--LLQEERDKLITEMDRSLLENQSLSSSC 1535
Query: 175 HTEHNAVQGT--DAEKVSAMINDMRSRII-----------ELEKKCEALDNEVYDKQMEL 221
+ A++G D EK+ I ++S I EL+K+ E L + E
Sbjct: 1536 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1595
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
++ V+ ++L KL S E ET+++L+ + E E +R+ K +
Sbjct: 1596 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME---EMKEKMRKFAKSKQ 1652
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ + +L+EE + ++ + K + S N +KE+ E ++ + L K Q
Sbjct: 1653 QKI-LELEEENDRLRAEVHPAGDTAKECMETLLSS--NASMKEELERVKMEYETLSKKFQ 1709
Query: 342 EMKAKLEQIEESASEKLKICE--IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
+ ++ + + E + E + + ++ ++H +Q T + + E + L
Sbjct: 1710 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL 1769
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK---DELIEKTINYENEKNKLNLA 456
+ + + + + K+ +S + F+ +EI D+L E+ E EK K
Sbjct: 1770 SMSTRPTCSESVPSAKSANPAVSKD-FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF 1828
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
+ EKN + +S D EL+ L+++V + + ++ EL+
Sbjct: 1829 SQTLENEKNTLLSQIST--------------KDGELKMLQEEVTKMNLLNQQIQEELSRV 1874
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
E D+ +E L+N L + + +VT + + + + L
Sbjct: 1875 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ----DVTDAQIKNELLESEMKNLKKC 1930
Query: 577 KNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAAD 636
+EL E+ + L KE + E+ K+ + + LL + +
Sbjct: 1931 VSELEEEKQQLVKEKTK----VESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 1986
Query: 637 LSRLENENERYXXXXXXXXSLVVELSLLRQENE-ELTMTVAKQSSIIDKLKK 687
+ +L+ + RY V L ++ E++ +L +T + ++ KK
Sbjct: 1987 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2038
Score = 59.3 bits (137), Expect = 5e-08
Identities = 98/462 (21%), Positives = 188/462 (40%), Gaps = 38/462 (8%)
Query: 131 KNEIAQLQEILKELATKFRQSHNN-IDFNE----IDRKLSKLRINNTNCH-----TEHNA 180
K+ +LQE+LKE + +Q + I + E ++R + L T T+ N
Sbjct: 1970 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL 2029
Query: 181 VQGTD-AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q + +K A + + + + + + + + + EL S +E + S K
Sbjct: 2030 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK---SQMKQKD 2086
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI-ELEALKTKLDEEKQAIISK 298
E L L AE + E L E + E I E++ K D+E Q +
Sbjct: 2087 EDL-ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQEN 2145
Query: 299 CK--VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE 356
V Q TK +S++ +++++ E + + + KE+E++ K + +
Sbjct: 2146 LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV-LKD 2204
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
+L+ I EE +I ++ + E++ + D +N +L +L ++
Sbjct: 2205 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2264
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLN--LAVEKAIKEKNKF---- 467
E E+K+LKD+L + + + E +K L + ++A + +KF
Sbjct: 2265 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ 2324
Query: 468 -ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE 526
ET L +R+ LT RL E E+ E ++ L S KE E +E
Sbjct: 2325 LETDLQASRE----LTSRLHE---EINMKEQKIISLLSGKE--EAIQVAIAELRQQHDKE 2375
Query: 527 CDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
E + L + L +E+ + ++ L+E+L+ ++KE
Sbjct: 2376 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2417
Score = 58.8 bits (136), Expect = 6e-08
Identities = 94/488 (19%), Positives = 203/488 (41%), Gaps = 41/488 (8%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q+EL + + E+++ + + + +E K + L+ I+++ + S + +++
Sbjct: 2270 QNELAKLES-ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS--KFSYEQLE 2326
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
L R + H E N + +S ++ I EL ++ D E+ + + L
Sbjct: 2327 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH---DKEIKELENLL 2383
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S EE V + K +K TL ++ K +++ S++ + + +
Sbjct: 2384 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND-RDRI 2442
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+L+E +II ++++ L + A +N LKE+ L L +
Sbjct: 2443 VGDYQQLEERHLSII----LEKDQLIQEAAA-----ENNKLKEEIRGLRSHMDDLNSENA 2493
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ A+L Q E ++ + I+ ++ Q ++ Q ++ LE + +L+ L +
Sbjct: 2494 KLDAELIQYREDLNQ---VITIKDSQQKQLLEVQLQQNKE----LENKYAKLEEKLKESE 2546
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN------KLNL 455
N DL++ N L+ K +LS E IE +K +L + + E +L +
Sbjct: 2547 EANEDLRRSFNALQEEKQDLSKE----IESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2602
Query: 456 AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED----QVQMLTSAKEVLEN 511
E+ + F +S ++ L +E+ ++ ++ED +++ L ++ N
Sbjct: 2603 KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN 2662
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
E T + + R+ E ++ L+ + K LT + ++ + SLQN A
Sbjct: 2663 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQ----IQSFGRSMSSLQNSRDHANE 2718
Query: 572 ELGTIKNE 579
EL +K +
Sbjct: 2719 ELDELKRK 2726
Score = 55.2 bits (127), Expect = 8e-07
Identities = 117/616 (18%), Positives = 246/616 (39%), Gaps = 33/616 (5%)
Query: 86 SSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE- 143
SSI+ + L K+ Q L++AQ+ D+ + E + I D N+ + E +
Sbjct: 456 SSIELEELKAENEKLSSQITLLEAQN-RTGEADREVSEIS--IVDIANKRSSSAEESGQD 512
Query: 144 -LATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM-INDMRSRII 201
L F Q H + ++ K ++ I + + D E + + M I
Sbjct: 513 VLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 572
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
K L++ D + + + V + TS E++L + L+ K
Sbjct: 573 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQ 632
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
+L A I + ++ ELE LK+++ E + ++ ++NL K I +L NQ+
Sbjct: 633 DGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAK-EISNL-NQL 690
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEE-----SASEKLKICEIQFEERSQSIQEHC 376
++E + + S +E L Q++E ++K E+ E + +
Sbjct: 691 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 750
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q L ++I L + + L+ EL++++ E ST + +++ +
Sbjct: 751 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 810
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
E++E + +K+ + +A+ +K L +T+ + +L + R+ ++ + +E
Sbjct: 811 SEVLEGAERVRHISSKVE-ELSQALSQK-----ELEITK-MDQLLLEKKRDVETLQQTIE 863
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
++ Q +T + ++ + E KE L N+L KE ++ E N
Sbjct: 864 EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAKKE--QVEEDNE 920
Query: 557 TLIESLQNVEKEAYRELGTI-KNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXX 615
QN ++ + G I K EL + +LLKKE+ + + L+ + ++ L +
Sbjct: 921 VSSGLKQNYDEMS--PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL 978
Query: 616 XXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
S+ + + + +E + E S E+ + L T+
Sbjct: 979 EEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY------LKQTI 1032
Query: 676 AKQSSIIDKLKKDLEQ 691
+++ + ++KDLE+
Sbjct: 1033 SEKEVELQHIRKDLEE 1048
Score = 54.0 bits (124), Expect = 2e-06
Identities = 97/528 (18%), Positives = 219/528 (41%), Gaps = 47/528 (8%)
Query: 104 ELVQAQDVEIRNK----DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE 159
E+ Q+ E+ NK ++ + E + ED + LQE ++L+ + + ++
Sbjct: 2522 EVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL--KVSISQ 2579
Query: 160 IDRKLSKLRINNT-NCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNE----- 213
+ R+++ L+ T + V+ + ++SA+ + + RI ELE++ + E
Sbjct: 2580 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2639
Query: 214 --VYDK-QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV----KGHHAL- 265
+ DK + EL L + + + +E++ L E +Q+L MV KG A
Sbjct: 2640 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQI 2699
Query: 266 -----ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK-- 318
++ + ++ R EL+ LK K D + + ++ K +Q L + +A +
Sbjct: 2700 QSFGRSMSSLQNSRDHANEELDELKRKYDASLKEL-AQLK-EQGLLNRERDALLSETAFS 2757
Query: 319 -NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE----KLKICEIQFE------- 366
N + LE+L+ QL+ K++++ Q+E+S ++ + +Q E
Sbjct: 2758 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2817
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
E+ + +E + E++ LK + N L +EL NL+ +++ E
Sbjct: 2818 LEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE- 2876
Query: 426 FNFIEEIKTLKDELIEKTINY---ENEKNKLNLAVEKAIKEKNKFETSLSV-TRDIVHVL 481
+ +K E +KT + + E + NL+ + + + ++S + R +
Sbjct: 2877 ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELDQLRMEKSSWEIHERRMKEQY 2936
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ + + D +L L++ ++ L S+ + Y+ + + + LV +
Sbjct: 2937 LMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL 2996
Query: 542 AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKK 589
+ + + I+ L + + E T+ +L + + L++
Sbjct: 2997 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRE 3044
Score = 48.0 bits (109), Expect = 1e-04
Identities = 112/503 (22%), Positives = 205/503 (40%), Gaps = 43/503 (8%)
Query: 206 KCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV--KGHH 263
KC+ + E+Y KQ E+ +R KDL+EKL + E A +Q + + K +
Sbjct: 1020 KCQEI--EIYLKQTISEKEVELQHIR----KDLEEKLAAEEQFQALVKQMNQTLQDKTNQ 1073
Query: 264 ALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
L+A S + +L T D + A++ + V + S E K + L
Sbjct: 1074 IDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVV----ISPPCTGSSEHWKPE-L 1128
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS---IQEHCSQQ 379
+EK ALE+ QL K QE + I + A EK + + +++ +QE +Q
Sbjct: 1129 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1188
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK--FNFIEEIKT--- 434
K + + ++++L+ + + + + L + ++C E+ F E+ T
Sbjct: 1189 SKENENIGDQLRQLQ--IQVRESIDGKL-PSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1245
Query: 435 LKDELIEKTINYENEKNKLNLAVEKA-IKEKNKFETSLSVTRDI-VHVLTLRLRESDSEL 492
L+ L ++ + + L A IK + K + V ++ V T L + E+
Sbjct: 1246 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1305
Query: 493 EQLEDQVQ---MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHT 549
QL++Q+ + + + + +E + +L + E + + A + L+ E
Sbjct: 1306 FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL-ESSQLQIAGLEHLRELQPKLDELQ 1364
Query: 550 RIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK---KESNSQIKFLREEVEKKR 606
+++ + L E L I+ E+IE +L+K + Q K E +++ +
Sbjct: 1365 KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1424
Query: 607 V-LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR 665
V LCEM ++ AA +SR E E SL ELSL R
Sbjct: 1425 VELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN--------KSLQEELSLAR 1476
Query: 666 QENEELTMTVAKQSSIIDKLKKD 688
E LT ++A S + K+
Sbjct: 1477 GTIERLTKSLADVESQVSAQNKE 1499
>DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein.
Length = 2479
Score = 86.6 bits (205), Expect = 3e-16
Identities = 116/547 (21%), Positives = 235/547 (42%), Gaps = 57/547 (10%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEID 161
ELV+ ++ EI+ + I EY + I + EI Q + +E + Q +++ + D
Sbjct: 1364 ELVKDKE-EIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFD 1422
Query: 162 RKLSKLR------INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
R+ +++ T + + E I + I+E C++L+ ++
Sbjct: 1423 RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLK 1482
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKL---TSNELTLAETQQRLEMVKGHHALALE---- 268
+K+ L E+ I RD + +L+ +L E +AE ++ K HH L +
Sbjct: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 1542
Query: 269 ANESIRREYKIEL----EALKTKLDEEKQAIISKCKVD----QENLKTKHNASIESLKN- 319
AN R K E+ + L K EE++ I+ K + D L+ + ++S+ K
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
Query: 320 --QMLKE------------KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
++K+ + +EQ ++ + KL+++ + + +I E++
Sbjct: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
+E + E ++ ++ E+++LKY LD + ++ LK EL K T
Sbjct: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTT 1722
Query: 426 F-NFIEEIKT---LKDELIEKTIN---YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
N +E +K+ LK++ +K ++ E A E+ I ++ E L+V +
Sbjct: 1723 MRNLVERLKSQLALKEKQ-QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ--- 1778
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
++ RE +++E L + + L A + +N + + LN+ E + ++A IL
Sbjct: 1779 -IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKIL 1837
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL 598
+ K + +E+ + L LQ + L K LIE+++ K+ +Q++
Sbjct: 1838 REKEEIDQENDELKRQIKRLTSGLQG------KPLTDNKQSLIEELQRKVKKLENQLEGK 1891
Query: 599 REEVEKK 605
EEV+ K
Sbjct: 1892 VEEVDLK 1898
Score = 68.1 bits (159), Expect = 1e-10
Identities = 134/673 (19%), Positives = 280/673 (41%), Gaps = 47/673 (6%)
Query: 77 AFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ 136
A +++ + I+ TL K K + + + + R KD+ + E K+++DY++ +
Sbjct: 398 ASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYG 457
Query: 137 LQEILKELAT-KFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIND 195
L++ + E+ K + + + + ++++KL + ++ E+ A++ + MI+
Sbjct: 458 LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL 517
Query: 196 MRSRIIE-LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK--------LTSNE 246
R + L+++ +N++ K++E S EE + ++ + + QE+ LT+ +
Sbjct: 518 TEFRNSKHLKQQQYRAENQILLKEIE-SLEEERLDLKKKIRQMAQERGKRSATSGLTTED 576
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L L E + + + L + K E + + +++E+ S+ + +
Sbjct: 577 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLS-RELIEKERDLERSRTVIAKFQN 635
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE-KLKICEIQF 365
K K + +KE +A++++ +K E + +E + + K E F
Sbjct: 636 KLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIF 695
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL-STE 424
+ S ++ Q + L QE++E + + Q + ++++L+ L +E
Sbjct: 696 -DASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSE 754
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNK--LNLAVEKAIKEK--NKFETSL-SVTRD--- 476
N + + L D + + + N +N+ ++L E KEK E SL R
Sbjct: 755 GSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAV 814
Query: 477 IVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-------LTTYKNTLNNTVRECDE 529
I H +L +E SE E + + + + K LE++ + Y N LN + DE
Sbjct: 815 IRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDE 874
Query: 530 YKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVEL 586
K+ L + L ++ TL+E + + KE + EL +++ E+ E +
Sbjct: 875 MKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGC 934
Query: 587 L---KKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL-----LAQAAADLS 638
L K+ + +I L++ V+ L E+ +L L Q ++L
Sbjct: 935 LQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLE 994
Query: 639 RLENEN----ERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQY 694
LE EN E+ +L + Q E+ T + +SS +DK KK + S
Sbjct: 995 HLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-KLGNESS-MDKAKKSITNSDI 1052
Query: 695 TPKSPSVLRKSLK 707
S + +K
Sbjct: 1053 VSISKKITMLEMK 1065
Score = 60.1 bits (139), Expect = 3e-08
Identities = 79/386 (20%), Positives = 162/386 (41%), Gaps = 26/386 (6%)
Query: 219 MELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM-VKGHHALALEANESIRREY 277
+ L+ +E+ + +D L KL L ++ E+ VK + L+ E+ E
Sbjct: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEV 1680
Query: 278 K---IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
K E+E LK LD+ ++ S+C LK++ A E+ +E+L S
Sbjct: 1681 KKVKAEVEDLKYLLDQSQKE--SQC------LKSELQAQKEANSRAPTTTMRNLVERLKS 1732
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
QL +KE++ KA + E +E E + + + H + Q Q +++ +ELK
Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQ----QIVDRHTRELK 1788
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
++ N LK+ L KN ++ L T+ N + K + K + + E ++ N
Sbjct: 1789 TQVEDLNENLLKLKEALKTSKNRENSL-TDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
Query: 455 LAVEKAIKEKNKFETSLSVT---RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+++ IK +T + ++ L ++++ +++LE ++V + ++ +
Sbjct: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
Query: 512 ELTTYKN------TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
EL ++ + + E + + + K L + + +TL L+
Sbjct: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTT 1967
Query: 566 EKEAYRELGTIKNELIEDVELLKKES 591
+ LG E +++E LKK +
Sbjct: 1968 GMTVDQVLGIRALESEKELEELKKRN 1993
Score = 57.6 bits (133), Expect = 1e-07
Identities = 127/571 (22%), Positives = 239/571 (41%), Gaps = 65/571 (11%)
Query: 96 KNKILP-QDELVQAQDV----EIRNKDQTICEYNKQ-------IEDYKNEIAQLQEILKE 143
K K++ ++EL AQ + R IC+ KQ +ED + E+ + +++ ++
Sbjct: 88 KTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQ 147
Query: 144 LATKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI-----NDMR 197
LA + ++ N N +++L K N C + + D++K + + +D R
Sbjct: 148 LALRNEEAENENSKLRRENKRLKKK--NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYR 205
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ------EKLTSN----EL 247
S +L KK L + + Q + E++ + K+L+ EK+T +
Sbjct: 206 S---QLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKA 262
Query: 248 TLAETQQRLEMVK---GHHALALEANESIRREYKIE----LEALKTKLDEEKQAIISKCK 300
+ +T ++ +K H+ L ++ + + E + A+ K++E K + SK
Sbjct: 263 IVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDD 322
Query: 301 VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK- 359
E + HN E LKN L + L + ++ ++K EQ+E+ E K
Sbjct: 323 EIIEYQQMLHNLR-EKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381
Query: 360 IC-------EIQFEERSQSIQEHCSQQ-EKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL 411
C E+Q + + ++ + + + T+ L+++ KE + T +L + +EL
Sbjct: 382 TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL 441
Query: 412 -NNLKNCKDELS--TEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNLAVEKAIKEKN 465
LK KD S + + EIK K+++ + E E NKL L + + E
Sbjct: 442 VEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENE 501
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ + + LT + +Q + Q+L E LE E K + +
Sbjct: 502 ALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQ 561
Query: 526 ECDEYKEALVNILKSKAALTK---EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
E + + A + LT+ + RI E + L+ SL+N+ EA + + ELIE
Sbjct: 562 ERGK-RSATSGLTTEDLNLTENISQGDRISERKLDLL-SLKNM-SEAQSKNEFLSRELIE 618
Query: 583 DVELLKKESNSQIKF---LREEVEKKRVLCE 610
L++ KF L+E VE+ + L E
Sbjct: 619 KERDLERSRTVIAKFQNKLKELVEENKQLEE 649
Score = 56.0 bits (129), Expect = 4e-07
Identities = 86/405 (21%), Positives = 179/405 (44%), Gaps = 33/405 (8%)
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
+D R EL+K+ L +E + + +L + + + +DL+E + AE Q
Sbjct: 2052 DDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111
Query: 254 QRLEMVKGHHALAL---EANESIRREYKIELEALKTKLDEEKQA--IISKCK---VDQEN 305
++L V+G E ++I K+ +E ++ + ++ K+A I++ K ++QEN
Sbjct: 2112 RKLGHVRGSGRSGKTIPELEKTIGLMKKV-VEKVQRENEQLKKASGILTSEKMANIEQEN 2170
Query: 306 LKTKHNASIESLKNQM---LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
K K A +E LK + L E+ + ++I + + ++ +L++ E A+EKL+I +
Sbjct: 2171 EKLK--AELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-ETDAAEKLRIAK 2227
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
E ++ + + K +Q+ E +L+ + + LK + +++
Sbjct: 2228 NNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIA 2287
Query: 423 TEKFNFIEEIKTLKDELIEKT--INYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
+K I ++K L E E+ +N NE + + + K + E ET + R++ V
Sbjct: 2288 -KKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGA--ETEQGLKREL-QV 2343
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
L L + D E +L Q+ E ++ +T+ + D+ KE + ++
Sbjct: 2344 LRLANHQLDKEKAELIHQI------------EANKDQSGAESTIPDADQLKEKIKDLETQ 2391
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
E + E L + L+N + + E+ +K E+V+
Sbjct: 2392 LKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVK 2436
Score = 54.8 bits (126), Expect = 1e-06
Identities = 77/397 (19%), Positives = 168/397 (42%), Gaps = 22/397 (5%)
Query: 314 IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+ LK++ + S + +K QE++ LE++E++ E+ K E Q + + ++
Sbjct: 37 VNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKF-ENQLKTKVMKLE 95
Query: 374 E--HCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF 428
+QQ + ++L EI +L+ L+ + + D+++EL K ++L+
Sbjct: 96 NELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEA 155
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E L+ E K + +NE+ ++ ++ + ++ ET LS R +L +
Sbjct: 156 ENENSKLRRE--NKRLKKKNEQLCQDI-IDYQKQIDSQKETLLS-RRGEDSDYRSQLSKK 211
Query: 489 DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE----CDEYK--EALVNILKSKA 542
+ EL Q D++Q LT A E +E + + L +V+E DEY +A+V+ +
Sbjct: 212 NYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVI 271
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
K+ + V + L + E + N +E+ +L+ + +I ++ +
Sbjct: 272 DQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQML 331
Query: 603 EKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS 662
R ++ + + + + + L + E+Y ++ +L
Sbjct: 332 HNLRE--KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLK 389
Query: 663 LLRQENEELT----MTVAKQSSIIDKLKKDLEQSQYT 695
Q N+ + T K S +D LK+ ++++ T
Sbjct: 390 NELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERT 426
Score = 54.0 bits (124), Expect = 2e-06
Identities = 98/481 (20%), Positives = 203/481 (42%), Gaps = 48/481 (9%)
Query: 117 DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLS--------K 166
D+ E Q+ED + +L+E LK + +N++ NE+ +K K
Sbjct: 1781 DRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREK 1840
Query: 167 LRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK--------Q 218
I+ N + + T + + ++ +S I EL++K + L+N++ K
Sbjct: 1841 EEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 1900
Query: 219 MELSSLEEVITVRD-----SLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI 273
E ++ EE+I + + + ++ KL E + ++L +K A A + ++
Sbjct: 1901 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTL 1960
Query: 274 RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES----LKNQMLKEKCEAL 329
+R +L+ +D+ + + + E LK K N +E+ ++ + +
Sbjct: 1961 QR----KLKTTGMTVDQVLGIRALESEKELEELK-KRNLDLENDILYMRAHQALPRDSVV 2015
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E LH Q ++++ A +Q + K I I+ ++ Q QE Q++ ++ L E
Sbjct: 2016 EDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQE---LQKENLK-LSSE 2071
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE-LIEKTI-NYE 447
ELK+ L+ N LK ++ +LK + L EK ++ ++ KTI E
Sbjct: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 2131
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ VEK +E + + + + + + ++ + E E+L+ +++ L K
Sbjct: 2132 KTIGLMKKVVEKVQRENEQLKKASGI------LTSEKMANIEQENEKLKAELEKL---KA 2182
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L ++L+ + + + E L LK K E RI ++N+ ++ V+
Sbjct: 2183 HLGHQLSMHYESKTKGTEKIIAENERLRKELK-KETDAAEKLRIAKNNLEILNEKMTVQL 2241
Query: 568 E 568
E
Sbjct: 2242 E 2242
Score = 52.4 bits (120), Expect = 5e-06
Identities = 77/341 (22%), Positives = 164/341 (48%), Gaps = 25/341 (7%)
Query: 117 DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHT 176
++TI K +E + E QL++ + T + ++ + ++ +L KL+ + + +
Sbjct: 2131 EKTIGLMKKVVEKVQRENEQLKKA-SGILTSEKMANIEQENEKLKAELEKLKAHLGHQLS 2189
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
H + EK+ A +R EL+K+ +A + K L L E +TV+
Sbjct: 2190 MHYESKTKGTEKIIAENERLRK---ELKKETDAAEKLRIAKN-NLEILNEKMTVQ----- 2240
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
L+E T L AE+ R ++G + + ++ + R Y+ +L+ L+T + ++ Q+I
Sbjct: 2241 -LEE--TGKRLQFAES--RGPQLEGADSKSWKSIV-VTRMYETKLKELETDIAKKNQSIT 2294
Query: 297 SKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE 356
++ +E T+ + N+ L+++ + L+ + + EQ +K +L Q+ A+
Sbjct: 2295 DLKQLVKE--ATEREQKVNKY-NEDLEQQIKILKHV-PEGAETEQGLKREL-QVLRLANH 2349
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
+L + + + ++ ++ S E TI L+++IK+L+ L +++ + LK+E+
Sbjct: 2350 QLDKEKAELIHQIEANKDQ-SGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
LK + F IE++K E ++K I E + KL+
Sbjct: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLS 2449
Score = 50.4 bits (115), Expect = 2e-05
Identities = 106/519 (20%), Positives = 218/519 (42%), Gaps = 51/519 (9%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR---INNTNC 174
Q + ++ +IE+ + + +L L + + + +N I +E +R +S L +
Sbjct: 1342 QKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNII--SEYERTISSLEEEIVQQNKF 1399
Query: 175 HTEHNAV---QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVIT-- 229
H E + D E+ + + ++ I+ +K E + D + L + E+
Sbjct: 1400 HEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459
Query: 230 VRDSL---------CKDLQEKLTSNE--LTLAETQQRLEMVKGHHALALEANESIRREYK 278
+++++ CK L+EKL E L LAE Q L K + L L + RE K
Sbjct: 1460 IKENIRIILETRATCKSLEEKLKEKESALRLAE-QNILSRDKVINELRLRLPATAERE-K 1517
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
+ E + +++ + + N++ + N E LK Q L EK A E+ +
Sbjct: 1518 LIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEK--AREEQREIVK 1575
Query: 338 IKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTL 397
E+++ ++E A L +F++ + + + T ++ + + E++ T+
Sbjct: 1576 KHEEDLHILHHRLELQADSSLN----KFKQTAWDLMKQSPTPVPTNKHFIR-LAEMEQTV 1630
Query: 398 DLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAV 457
Q+ L L LK +L ++ ++K ++ ++ N+E+E K+ V
Sbjct: 1631 ---AEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV 1687
Query: 458 E-------KAIKEKNKFETSLSVTRDI---VHVLTLR--LRESDSELEQLEDQVQMLTSA 505
E ++ KE ++ L ++ T+R + S+L E Q + L+ A
Sbjct: 1688 EDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRA 1747
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQN 564
L E+T + KEA +N+ + T+E T++ + N L++ +
Sbjct: 1748 LLELRAEMTA---AAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEA 1804
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++ RE ++ + L + L+K+ + K LRE+ E
Sbjct: 1805 LKTSKNRE-NSLTDNLNDLNNELQKKQKAYNKILREKEE 1842
Score = 50.0 bits (114), Expect = 3e-05
Identities = 86/509 (16%), Positives = 219/509 (43%), Gaps = 30/509 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K K N + + + + +I Q E + ++ E + + + N ++ Y +EI L
Sbjct: 167 KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLT 226
Query: 139 EILKELATKFRQSHNNID--FNEIDRKLSKLRINNTNCHTEHNAVQGTDAE------KVS 190
E +++ + ++ N++ E+++ + H N + E +V
Sbjct: 227 EANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQ 286
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL--- 247
+ + ++S+ E + A++ +V + ++ LSS ++ I + +L+EKL + +L
Sbjct: 287 ELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDAD 346
Query: 248 --TLAETQQRLEMVKGHHALALEANESIRREYKIE---LEALKTKLDEEKQAIISKCKVD 302
+ QQ ++ + E E +E + +E LK +L K A
Sbjct: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGA---STLSQ 403
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
Q ++K + ++++ LK + KE E + K++E+ L+++++ S + +
Sbjct: 404 QTHMKIQ--STLDILK-EKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLED 460
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKD-- 419
E ++ + +++ I+ L +EI +L+ + ++N L++ + K D
Sbjct: 461 AVVE--IKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLT 518
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E K ++ + L+++ + E E+ L + + +E+ K + +T + ++
Sbjct: 519 EFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN 578
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
LT + + D E+ D + + ++ +NE + L R+ + + +
Sbjct: 579 -LTENISQGDRISERKLDLLSLKNMSEAQSKNEFLS--RELIEKERDLERSRTVIAKFQN 635
Query: 540 SKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L +E+ ++ E ++++++ ++K+
Sbjct: 636 KLKELVEENKQLEEGMKEILQAIKEMQKD 664
Score = 44.0 bits (99), Expect = 0.002
Identities = 87/436 (19%), Positives = 176/436 (40%), Gaps = 35/436 (8%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITV-RDSLCKDL--QEKLTSNELTLAETQQR 255
R +E EK+ E L D + ++ + + RDS+ +DL Q + +L E Q
Sbjct: 1978 RALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFS 2037
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASI 314
+ +E+++ +RE +++ E LK + E + + + D LK + +
Sbjct: 2038 KDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVR-DL 2096
Query: 315 ESLKNQMLKEKCEALEQL-------HSQLIIKEQE-----MKAKLEQIEESASEKLKICE 362
+ + + KEK E +L S I E E MK +E+++ + K
Sbjct: 2097 KEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASG 2156
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKE---LKYTLDLTNNQ-----NSDLKQELNNL 414
I E+ +I++ + + ++ L+ + + Y + N L++EL
Sbjct: 2157 ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKE 2216
Query: 415 KNCKDELSTEKFNF--IEEIKTLKDELIEKTINY-ENEKNKLNLAVEKAIKE---KNKFE 468
+ ++L K N + E T++ E K + + E+ +L A K+ K +E
Sbjct: 2217 TDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE 2276
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
T L + + + +++ ++ Q + E LE ++ K+ E
Sbjct: 2277 TKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETE-Q 2335
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK 588
K L + + L KE ++ H + + E + +K E I+D+E
Sbjct: 2336 GLKRELQVLRLANHQLDKEKAELI-HQIEANKDQSGAES-TIPDADQLK-EKIKDLETQL 2392
Query: 589 KESNSQIKFLREEVEK 604
K S+ + + L+EE++K
Sbjct: 2393 KMSDLEKQHLKEEIKK 2408
Score = 39.5 bits (88), Expect = 0.041
Identities = 80/347 (23%), Positives = 148/347 (42%), Gaps = 31/347 (8%)
Query: 158 NEIDRKLSKLRINNTNCHTEH-NAVQGTDAEKVSAMINDMRSRIIELEKK-CEAL--DNE 213
NE +K S + + + E N + EK+ A + S E + K E + +NE
Sbjct: 2148 NEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENE 2207
Query: 214 VYDKQM--ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
K++ E + E++ +++L + L EK+T + L ET +RL+ + LE +
Sbjct: 2208 RLRKELKKETDAAEKLRIAKNNL-EILNEKMT---VQLEETGKRLQFAESRGP-QLEGAD 2262
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
S + + +TKL E + I K N SI LK Q++KE E ++
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKK------------NQSITDLK-QLVKEATEREQK 2309
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
++ EQ++K L+ + E A + + + E + + H +EK + E
Sbjct: 2310 VNKYNEDLEQQIKI-LKHVPEGAETEQGL---KRELQVLRLANHQLDKEKAELIHQIEAN 2365
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN 451
+ + + T LK+++ +L+ EK + EEIK LK EL ++ E
Sbjct: 2366 KDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIE 2425
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
L ++ +K+ E + + + L + L + E+ ED+
Sbjct: 2426 DLKYNYKEEVKKNILLEEKV---KKLSEQLGVELTSPVAASEEFEDE 2469
>AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein.
Length = 1540
Score = 86.6 bits (205), Expect = 3e-16
Identities = 116/547 (21%), Positives = 235/547 (42%), Gaps = 57/547 (10%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEID 161
ELV+ ++ EI+ + I EY + I + EI Q + +E + Q +++ + D
Sbjct: 425 ELVKDKE-EIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFD 483
Query: 162 RKLSKLR------INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
R+ +++ T + + E I + I+E C++L+ ++
Sbjct: 484 RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLK 543
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKL---TSNELTLAETQQRLEMVKGHHALALE---- 268
+K+ L E+ I RD + +L+ +L E +AE ++ K HH L +
Sbjct: 544 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 603
Query: 269 ANESIRREYKIEL----EALKTKLDEEKQAIISKCKVD----QENLKTKHNASIESLKN- 319
AN R K E+ + L K EE++ I+ K + D L+ + ++S+ K
Sbjct: 604 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 663
Query: 320 --QMLKE------------KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
++K+ + +EQ ++ + KL+++ + + +I E++
Sbjct: 664 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 723
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
+E + E ++ ++ E+++LKY LD + ++ LK EL K T
Sbjct: 724 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTT 783
Query: 426 F-NFIEEIKT---LKDELIEKTIN---YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
N +E +K+ LK++ +K ++ E A E+ I ++ E L+V +
Sbjct: 784 MRNLVERLKSQLALKEKQ-QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ--- 839
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
++ RE +++E L + + L A + +N + + LN+ E + ++A IL
Sbjct: 840 -IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKIL 898
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL 598
+ K + +E+ + L LQ + L K LIE+++ K+ +Q++
Sbjct: 899 REKEEIDQENDELKRQIKRLTSGLQG------KPLTDNKQSLIEELQRKVKKLENQLEGK 952
Query: 599 REEVEKK 605
EEV+ K
Sbjct: 953 VEEVDLK 959
Score = 60.1 bits (139), Expect = 3e-08
Identities = 79/386 (20%), Positives = 162/386 (41%), Gaps = 26/386 (6%)
Query: 219 MELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM-VKGHHALALEANESIRREY 277
+ L+ +E+ + +D L KL L ++ E+ VK + L+ E+ E
Sbjct: 682 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEV 741
Query: 278 K---IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
K E+E LK LD+ ++ S+C LK++ A E+ +E+L S
Sbjct: 742 KKVKAEVEDLKYLLDQSQKE--SQC------LKSELQAQKEANSRAPTTTMRNLVERLKS 793
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
QL +KE++ KA + E +E E + + + H + Q Q +++ +ELK
Sbjct: 794 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQ----QIVDRHTRELK 849
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
++ N LK+ L KN ++ L T+ N + K + K + + E ++ N
Sbjct: 850 TQVEDLNENLLKLKEALKTSKNRENSL-TDNLNDLNNELQKKQKAYNKILREKEEIDQEN 908
Query: 455 LAVEKAIKEKNKFETSLSVT---RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+++ IK +T + ++ L ++++ +++LE ++V + ++ +
Sbjct: 909 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 968
Query: 512 ELTTYKN------TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
EL ++ + + E + + + K L + + +TL L+
Sbjct: 969 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTT 1028
Query: 566 EKEAYRELGTIKNELIEDVELLKKES 591
+ LG E +++E LKK +
Sbjct: 1029 GMTVDQVLGIRALESEKELEELKKRN 1054
Score = 56.0 bits (129), Expect = 4e-07
Identities = 86/405 (21%), Positives = 179/405 (44%), Gaps = 33/405 (8%)
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
+D R EL+K+ L +E + + +L + + + +DL+E + AE Q
Sbjct: 1113 DDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 1172
Query: 254 QRLEMVKGHHALAL---EANESIRREYKIELEALKTKLDEEKQA--IISKCK---VDQEN 305
++L V+G E ++I K+ +E ++ + ++ K+A I++ K ++QEN
Sbjct: 1173 RKLGHVRGSGRSGKTIPELEKTIGLMKKV-VEKVQRENEQLKKASGILTSEKMANIEQEN 1231
Query: 306 LKTKHNASIESLKNQM---LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
K K A +E LK + L E+ + ++I + + ++ +L++ E A+EKL+I +
Sbjct: 1232 EKLK--AELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKK-ETDAAEKLRIAK 1288
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
E ++ + + K +Q+ E +L+ + + LK + +++
Sbjct: 1289 NNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIA 1348
Query: 423 TEKFNFIEEIKTLKDELIEKT--INYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
+K I ++K L E E+ +N NE + + + K + E ET + R++ V
Sbjct: 1349 -KKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGA--ETEQGLKREL-QV 1404
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
L L + D E +L Q+ E ++ +T+ + D+ KE + ++
Sbjct: 1405 LRLANHQLDKEKAELIHQI------------EANKDQSGAESTIPDADQLKEKIKDLETQ 1452
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
E + E L + L+N + + E+ +K E+V+
Sbjct: 1453 LKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVK 1497
Score = 54.0 bits (124), Expect = 2e-06
Identities = 98/481 (20%), Positives = 203/481 (42%), Gaps = 48/481 (9%)
Query: 117 DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLS--------K 166
D+ E Q+ED + +L+E LK + +N++ NE+ +K K
Sbjct: 842 DRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREK 901
Query: 167 LRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK--------Q 218
I+ N + + T + + ++ +S I EL++K + L+N++ K
Sbjct: 902 EEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 961
Query: 219 MELSSLEEVITVRD-----SLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI 273
E ++ EE+I + + + ++ KL E + ++L +K A A + ++
Sbjct: 962 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTL 1021
Query: 274 RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES----LKNQMLKEKCEAL 329
+R +L+ +D+ + + + E LK K N +E+ ++ + +
Sbjct: 1022 QR----KLKTTGMTVDQVLGIRALESEKELEELK-KRNLDLENDILYMRAHQALPRDSVV 1076
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E LH Q ++++ A +Q + K I I+ ++ Q QE Q++ ++ L E
Sbjct: 1077 EDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQE---LQKENLK-LSSE 1132
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE-LIEKTI-NYE 447
ELK+ L+ N LK ++ +LK + L EK ++ ++ KTI E
Sbjct: 1133 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 1192
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ VEK +E + + + + + + ++ + E E+L+ +++ L K
Sbjct: 1193 KTIGLMKKVVEKVQRENEQLKKASGI------LTSEKMANIEQENEKLKAELEKL---KA 1243
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L ++L+ + + + E L LK K E RI ++N+ ++ V+
Sbjct: 1244 HLGHQLSMHYESKTKGTEKIIAENERLRKELK-KETDAAEKLRIAKNNLEILNEKMTVQL 1302
Query: 568 E 568
E
Sbjct: 1303 E 1303
Score = 52.4 bits (120), Expect = 5e-06
Identities = 77/341 (22%), Positives = 164/341 (48%), Gaps = 25/341 (7%)
Query: 117 DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHT 176
++TI K +E + E QL++ + T + ++ + ++ +L KL+ + + +
Sbjct: 1192 EKTIGLMKKVVEKVQRENEQLKKA-SGILTSEKMANIEQENEKLKAELEKLKAHLGHQLS 1250
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
H + EK+ A +R EL+K+ +A + K L L E +TV+
Sbjct: 1251 MHYESKTKGTEKIIAENERLRK---ELKKETDAAEKLRIAKN-NLEILNEKMTVQ----- 1301
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
L+E T L AE+ R ++G + + ++ + R Y+ +L+ L+T + ++ Q+I
Sbjct: 1302 -LEE--TGKRLQFAES--RGPQLEGADSKSWKSIV-VTRMYETKLKELETDIAKKNQSIT 1355
Query: 297 SKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE 356
++ +E T+ + N+ L+++ + L+ + + EQ +K +L Q+ A+
Sbjct: 1356 DLKQLVKE--ATEREQKVNKY-NEDLEQQIKILKHV-PEGAETEQGLKREL-QVLRLANH 1410
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
+L + + + ++ ++ S E TI L+++IK+L+ L +++ + LK+E+
Sbjct: 1411 QLDKEKAELIHQIEANKDQ-SGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 1469
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
LK + F IE++K E ++K I E + KL+
Sbjct: 1470 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLS 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 106/519 (20%), Positives = 218/519 (42%), Gaps = 51/519 (9%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR---INNTNC 174
Q + ++ +IE+ + + +L L + + + +N I +E +R +S L +
Sbjct: 403 QKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNII--SEYERTISSLEEEIVQQNKF 460
Query: 175 HTEHNAV---QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVIT-- 229
H E + D E+ + + ++ I+ +K E + D + L + E+
Sbjct: 461 HEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 520
Query: 230 VRDSL---------CKDLQEKLTSNE--LTLAETQQRLEMVKGHHALALEANESIRREYK 278
+++++ CK L+EKL E L LAE Q L K + L L + RE K
Sbjct: 521 IKENIRIILETRATCKSLEEKLKEKESALRLAE-QNILSRDKVINELRLRLPATAERE-K 578
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
+ E + +++ + + N++ + N E LK Q L EK A E+ +
Sbjct: 579 LIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEK--AREEQREIVK 636
Query: 338 IKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTL 397
E+++ ++E A L +F++ + + + T ++ + + E++ T+
Sbjct: 637 KHEEDLHILHHRLELQADSSLN----KFKQTAWDLMKQSPTPVPTNKHFIR-LAEMEQTV 691
Query: 398 DLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAV 457
Q+ L L LK +L ++ ++K ++ ++ N+E+E K+ V
Sbjct: 692 ---AEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV 748
Query: 458 E-------KAIKEKNKFETSLSVTRDI---VHVLTLR--LRESDSELEQLEDQVQMLTSA 505
E ++ KE ++ L ++ T+R + S+L E Q + L+ A
Sbjct: 749 EDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRA 808
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQN 564
L E+T + KEA +N+ + T+E T++ + N L++ +
Sbjct: 809 LLELRAEMTA---AAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEA 865
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++ RE ++ + L + L+K+ + K LRE+ E
Sbjct: 866 LKTSKNRE-NSLTDNLNDLNNELQKKQKAYNKILREKEE 903
Score = 44.0 bits (99), Expect = 0.002
Identities = 87/436 (19%), Positives = 176/436 (40%), Gaps = 35/436 (8%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITV-RDSLCKDL--QEKLTSNELTLAETQQR 255
R +E EK+ E L D + ++ + + RDS+ +DL Q + +L E Q
Sbjct: 1039 RALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFS 1098
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASI 314
+ +E+++ +RE +++ E LK + E + + + D LK + +
Sbjct: 1099 KDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVR-DL 1157
Query: 315 ESLKNQMLKEKCEALEQL-------HSQLIIKEQE-----MKAKLEQIEESASEKLKICE 362
+ + + KEK E +L S I E E MK +E+++ + K
Sbjct: 1158 KEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASG 1217
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKE---LKYTLDLTNNQ-----NSDLKQELNNL 414
I E+ +I++ + + ++ L+ + + Y + N L++EL
Sbjct: 1218 ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKE 1277
Query: 415 KNCKDELSTEKFNF--IEEIKTLKDELIEKTINY-ENEKNKLNLAVEKAIKE---KNKFE 468
+ ++L K N + E T++ E K + + E+ +L A K+ K +E
Sbjct: 1278 TDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE 1337
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
T L + + + +++ ++ Q + E LE ++ K+ E
Sbjct: 1338 TKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETE-Q 1396
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK 588
K L + + L KE ++ H + + E + +K E I+D+E
Sbjct: 1397 GLKRELQVLRLANHQLDKEKAELI-HQIEANKDQSGAES-TIPDADQLK-EKIKDLETQL 1453
Query: 589 KESNSQIKFLREEVEK 604
K S+ + + L+EE++K
Sbjct: 1454 KMSDLEKQHLKEEIKK 1469
Score = 39.5 bits (88), Expect = 0.041
Identities = 80/347 (23%), Positives = 148/347 (42%), Gaps = 31/347 (8%)
Query: 158 NEIDRKLSKLRINNTNCHTEH-NAVQGTDAEKVSAMINDMRSRIIELEKK-CEAL--DNE 213
NE +K S + + + E N + EK+ A + S E + K E + +NE
Sbjct: 1209 NEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENE 1268
Query: 214 VYDKQM--ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
K++ E + E++ +++L + L EK+T + L ET +RL+ + LE +
Sbjct: 1269 RLRKELKKETDAAEKLRIAKNNL-EILNEKMT---VQLEETGKRLQFAESRGP-QLEGAD 1323
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
S + + +TKL E + I K N SI LK Q++KE E ++
Sbjct: 1324 SKSWKSIVVTRMYETKLKELETDIAKK------------NQSITDLK-QLVKEATEREQK 1370
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
++ EQ++K L+ + E A + + + E + + H +EK + E
Sbjct: 1371 VNKYNEDLEQQIKI-LKHVPEGAETEQGL---KRELQVLRLANHQLDKEKAELIHQIEAN 1426
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN 451
+ + + T LK+++ +L+ EK + EEIK LK EL ++ E
Sbjct: 1427 KDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIE 1486
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
L ++ +K+ E + + + L + L + E+ ED+
Sbjct: 1487 DLKYNYKEEVKKNILLEEKV---KKLSEQLGVELTSPVAASEEFEDE 1530
>Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated
microtubule-binding protein protein.
Length = 1979
Score = 84.2 bits (199), Expect = 1e-15
Identities = 128/655 (19%), Positives = 297/655 (45%), Gaps = 73/655 (11%)
Query: 124 NKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG 183
+++I+D+++E++ LQ ++ T+ + H + ++ + ++ +L + V
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHRE-ELSDYEERIEELE---NLLQQGGSGVIE 281
Query: 184 TDAEKVSAM---INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
TD K+ M I ++ +E KK E L++++ D +LSS E RD L ++ QE
Sbjct: 282 TDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEND---RDILRRE-QE 337
Query: 241 KLTSNELTLAETQQRLEMVKGH-HALALEANESIRREYKI--------ELEALKTKLDEE 291
+L + + E + L++ A++ ++++ + +I E+ L+ L +
Sbjct: 338 QLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDA 397
Query: 292 KQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
+ I+ ++Q+N + N ++ ++ ++L+++ L Q +L + ++ + E I+
Sbjct: 398 ENEIMRLSSLNQDNSLAEDNLKLK-MRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456
Query: 352 ESASEKLKI------CEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTL---- 397
+A+ + + + E + Q + + S++E I +E Q + K+ +
Sbjct: 457 STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516
Query: 398 DLTNNQN------SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN--- 448
L+ QN S LKQ+LN+ K +L +K + +E+ K++LI+ + +
Sbjct: 517 QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL 576
Query: 449 EKNKLNLAVEKAIKEKNKF-ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
K KL VE + + NK E+++S+ ++ + L +R+++ EL ++ +++ +
Sbjct: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLE-LKEHIRQNEEELSRIRNELM-----QS 630
Query: 508 VLENELTTYKNTL-NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
+ ++ + +K+TL E K+ L + + L K + N L+ + ++V
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR 690
Query: 567 KE------AYRELGTIKNELIEDVELLKKESNSQI----KFLREEVEK-KRVLCEMXXXX 615
+ +L KN ++E +++ K E +++ K L EE K ++ + E+
Sbjct: 691 HQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNAR 750
Query: 616 XXXXXXXXXXSRVLLA---QAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELT 672
L+ + +++ L+ E+ + LS +E ++LT
Sbjct: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV---LSSSLEEQKQLT 807
Query: 673 MTVAKQSSIIDKLK-KDLEQSQYTPKSPSVLRKS---LKVGKENMQTISPLRERN 723
+ K+ I+KLK + + + K LRK+ + +E +++ ++E N
Sbjct: 808 QLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Score = 69.3 bits (162), Expect = 4e-11
Identities = 95/515 (18%), Positives = 223/515 (43%), Gaps = 30/515 (5%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
+I + Q I + ++ ++E+ + I + + + + + ++ + +L+ N
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNR 225
Query: 172 TNCHTEH----NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL--SSLE 225
+ +H + +Q +K++ + R + + E++ E L+N + + + L
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLS 285
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
++ ++ ++ EK+ S + + + + +++ + + A + +RRE + +L K
Sbjct: 286 KIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAENDRDILRREQE-QLNVEK 343
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK- 344
++ EE + + +C Q + + + E + E + +L L E E+
Sbjct: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMR 403
Query: 345 -AKLEQIEESASEKLKI-CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+ L Q A + LK+ I+ E+ +S+ SQ+++ +Q ++ + T
Sbjct: 404 LSSLNQDNSLAEDNLKLKMRIEVLEKEKSL---LSQEKEELQMSLLKLNNEYEVIKSTAT 460
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
++ L EL++L+ + E I E +TL E+ E + + L ++ K
Sbjct: 461 RDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSK 520
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
++N+ ++ I+ L L + + QLED +T +V + +L + LN+
Sbjct: 521 QQNEGDS-------IISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALND 573
Query: 523 ---TVRECDEYKEALVNIL----KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
T ++ ++ E LV+ L +S ++ KE+ + EH E L + E + L
Sbjct: 574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
N +D L KE ++++ L++ + + L E
Sbjct: 634 DSNSNFKDT--LLKEREAEVRNLKQNLSELEQLNE 666
Score = 66.5 bits (155), Expect = 3e-10
Identities = 111/566 (19%), Positives = 237/566 (41%), Gaps = 41/566 (7%)
Query: 102 QDELVQA--QDVEIRNKDQTICEYNKQIEDYK---NEIAQLQEILKELATKFRQSHNNID 156
++EL+Q+ QD KD + E ++ + K +E+ QL E LK++A + + +
Sbjct: 624 RNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLV 683
Query: 157 F--NEIDRKLSKLRINNTNCHTEHNAVQGT---DAEKVSAMINDMRSRIIELEKKCEALD 211
++ +L + N E N + T + ++ A + + R++E K E
Sbjct: 684 LACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI 743
Query: 212 NEVYD-KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
E+ + + + S+L+ + L K Q+K ++ +AE ++ +E + H +
Sbjct: 744 EELSNARNLNTSALQ---LEHEHLIKLNQKK----DMEIAELKKNIEQMDTDHKETKDVL 796
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL-KNQMLKEKCEAL 329
S E K +L T+L +K+ I K K L+ + + ++L KN++L++ E
Sbjct: 797 SSSLEEQK-QL----TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEK 851
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
++ + + ++ +LE++ E S + + + + + SQ ++LE+E
Sbjct: 852 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE 911
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
IK + ++ +QN Q L +L+ K E+ ++ + T +EK ++
Sbjct: 912 IKHHQKIIE---DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 968
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE--DQVQMLTSAKE 507
+ + + +E+ +T S V +L + E+ SE L + +++ KE
Sbjct: 969 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI-ENGSEKHDLSKAETERLVKGIKE 1027
Query: 508 -VLENELTTYKN-TLNNTVREC--DEYKEALVNILKSKAALTKEHTRI--MEHNVTLIES 561
LE +L KN +L + + DE + I + + H RI H ++
Sbjct: 1028 RELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYL 1087
Query: 562 LQNVEKEAY--RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXX 619
Q ++ A ++ + NE + LK E + + + K+ L ++
Sbjct: 1088 QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLS 1144
Query: 620 XXXXXXSRVLLAQAAADLSRLENENE 645
+ + + +LSR+ E +
Sbjct: 1145 TRFESSGQDMFRETIQNLSRIIREKD 1170
Score = 56.0 bits (129), Expect = 4e-07
Identities = 108/538 (20%), Positives = 234/538 (43%), Gaps = 47/538 (8%)
Query: 102 QDELVQAQD---VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
Q+EL Q Q V+ N + +Y I+ Y+ +L+ +ELA + + S + N
Sbjct: 1243 QEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA-QVQHSIGQL-CN 1300
Query: 159 EIDRKLSKL-----RINNTNCHTEHNA--VQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
D L KL ++++ + T +A ++ + +E +S ++ + EL K + D
Sbjct: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE--------MVKGHH 263
+ Q L + I L + E+ S L E Q L+ ++K
Sbjct: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
L +NE+ + E E L+ + K+ I+ ++D LK ++ +E+ + + +
Sbjct: 1421 DQLLSSNENFTNKVN-ENELLRQAVTNLKERILI-LEMDIGKLKGENEKIVETYRGKETE 1478
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE--ERSQSIQEHCSQQEK 381
+ + ++++E+E + + + A E+L + Q + E +Q + S QEK
Sbjct: 1479 YQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1538
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
T+ + +QE ++ L +N+ L+ E+ L++ ++F +E++ L++ L+E
Sbjct: 1539 TVVF-QQERDQVMLALKQKQMENTALQNEVQRLRD-------KEFRSNQELERLRNHLLE 1590
Query: 442 KTINYENE----KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+Y E +++ +K + K +S + + H ++++ +L +
Sbjct: 1591 SEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSK 1650
Query: 498 QVQMLTSAKEVLENELTTYKNTLNN---TVRECDEYKEALVNI-LKSKAALTKEHTRIME 553
Q V + ++ Y +L N + + ++A+ + L+ + L E + E
Sbjct: 1651 QRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAE 1710
Query: 554 HNVTLIESLQNVEKEAYRELGT---IKNEL---IEDVELLKKESNSQIKFLREEVEKK 605
+ + SLQ EA L + + +L E +E LK+++ + + L ++V+KK
Sbjct: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEML-DDVQKK 1767
Score = 42.7 bits (96), Expect = 0.004
Identities = 112/564 (19%), Positives = 235/564 (41%), Gaps = 78/564 (13%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
EI LQ+ ++++ T+ + +I + D + +K++ N +E + + + E++
Sbjct: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 192 MINDMRSRIIELEKKCEALDNEVYD-KQMELSSLEEVITVRDSLCKDLQEKLTSNELT-- 248
I + I L +K +L ++ + E+ L ++I +D + L +++S T
Sbjct: 1024 GIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD 1083
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK----CKVDQE 304
+ QQ+L+ +A+ E ++ E E LKT+ + + +K K+ E
Sbjct: 1084 VVYLQQQLQA----YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 1139
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
N K + ES M +E + L + II+E++++ ++ + + L + +
Sbjct: 1140 NKKL--STRFESSGQDMFRETIQNLSR-----IIREKDIE--IDALSQKCQTLLAVLQTS 1190
Query: 365 FE-ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+ + H Q E+ +Q + LKQ++ ++ K ++ T
Sbjct: 1191 STGNEAGGVNSH--QFEELLQ------------------ERDKLKQQVKKMEEWKQQVMT 1230
Query: 424 EKFNFIEEIKTLKDEL--IEKTINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
N E L++EL ++ + +++ N KL + I+ + ET
Sbjct: 1231 TVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET----------- 1279
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
+L+ EL Q++ + L + K++L +L L++ + E L S
Sbjct: 1280 ---KLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECL---RAS 1333
Query: 541 KAALTKEHTRIMEHNV-TLIESLQNVEKEA-YRELGTIKNELIEDV----ELLKKESNSQ 594
K+ + E + +++ + L +SLQ EK+A R L + L + + EL +KE
Sbjct: 1334 KSEVLSESSELLQQELEELRKSLQ--EKDATIRTLQENNHRLSDSIAATSELERKEHEQT 1391
Query: 595 IKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE--RYXXXXX 652
+++ EK+ VL ++ L + + + NENE R
Sbjct: 1392 DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQ----LLSSNENFTNKVNENELLRQAVTNL 1447
Query: 653 XXXSLVVELSL--LRQENEELTMT 674
L++E+ + L+ ENE++ T
Sbjct: 1448 KERILILEMDIGKLKGENEKIVET 1471
Score = 38.3 bits (85), Expect = 0.095
Identities = 89/440 (20%), Positives = 179/440 (40%), Gaps = 33/440 (7%)
Query: 307 KTKHNASIESL---KNQMLKEKCEALEQLH--SQLIIKEQEM--KAKLEQIEESASEKLK 359
+TK +I ++ +N+ LK+ C LE+ H S++ IK+Q + +L+Q E S LK
Sbjct: 53 RTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISH-LK 111
Query: 360 ICEIQFEERSQSIQEHCSQ-----------QEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+I +++ +Q + Y + D+ +
Sbjct: 112 ARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQ 171
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK--NKLNLAVEKAIKEKNK 466
QE+N L N L +E ++ +T K + + + E K N + + +E +
Sbjct: 172 QEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDD 231
Query: 467 FETSLSVTRDI-VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ +SV ++ LT R EL E++++ L + +L+ + T + +
Sbjct: 232 HQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL---ENLLQQGGSGVIETDLSKIY 288
Query: 526 ECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTL--IESLQNVEKEAYRELGTIKNELIE 582
E + + L + ++S + + +I + N L E+ +++ + +L K +++E
Sbjct: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348
Query: 583 DVELLKKESN----SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
+ E LK E + S +K EK+R+L + + L+
Sbjct: 349 ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLN 408
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKS 698
+ + E L E SLL QE EEL M++ K ++ + +K +
Sbjct: 409 QDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSE 468
Query: 699 PSVLRKSLKVGKENM-QTIS 717
LR +L+ ++ + Q+IS
Sbjct: 469 LHDLRLNLEAKEQELNQSIS 488
>J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplakin
mRNA, 3' end. ).
Length = 1752
Score = 83.8 bits (198), Expect = 2e-15
Identities = 113/499 (22%), Positives = 212/499 (42%), Gaps = 35/499 (7%)
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+KL S E + E + +E ++ + L+ + +REY+ EL ++ +EE + +K
Sbjct: 37 QKLES-EKAIKEKEYEIERLR----VLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKY 91
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK 359
+ + KT +I+ + Q + QL +L + +++K ++ ++ +S L+
Sbjct: 92 ETEINITKT----TIKEISMQKEDDSKNLRNQL-DRLSRENRDLKDEIVRLNDSI---LQ 143
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
E + ++Q+ E + EI ELK + + N+ KQ L
Sbjct: 144 ATEQRRRAEENALQQKACGSEIMQKKQHLEI-ELKQVMQQRSEDNARHKQSLEEAAKTIQ 202
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIV 478
+ + E IE +K E ++ YENE +K+ N E+ I KN+FET +++T+ +
Sbjct: 203 DKNKE----IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 258
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL--VN 536
H LT++ E S Q+ LT L E+ KNTL T +E +
Sbjct: 259 HQLTMQKEEDTSGYRA---QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 315
Query: 537 ILKSKAALTKEHTRIMEHNVTLIESLQNVE-KEAYRELG-TI--KNELIEDV-ELLKKES 591
S+ + K+ + VT + + ++V K++ + TI KN+ IE + +L+ KE+
Sbjct: 316 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 375
Query: 592 NSQIKFLREEVEKKRVLCEM--XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXX 649
N + E +RV ++ L + D R+ E
Sbjct: 376 NDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQ 435
Query: 650 XXXXXXSLVVELSLLRQENEE----LTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
+ + EL L +Q+ EE L T ++ S KL+++LE + + K ++ +
Sbjct: 436 DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITN 495
Query: 706 LKVGKENMQTISPLRERNL 724
L E + E +L
Sbjct: 496 LTQQLEQASIVKKRSEDDL 514
Score = 78.6 bits (185), Expect = 7e-14
Identities = 110/624 (17%), Positives = 254/624 (40%), Gaps = 40/624 (6%)
Query: 78 FKITKAPNSSIKKTLTCPKNKI----LPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNE 133
F K ++K C K + L ++ ++ ++ EI + E + +Y+NE
Sbjct: 13 FDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENE 72
Query: 134 IAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
+A+++ E + R + E + ++K I + E D++ + +
Sbjct: 73 LAKVRNHYNEEMSNLRNKY------ETEINITKTTIKEISMQKE------DDSKNLRNQL 120
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
+ + +L+ + L++ + + EE + + ++ +K E+ L +
Sbjct: 121 DRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVM 180
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHN-- 311
Q+ H +LE ++ E+E LK + EE + + + + E K ++N
Sbjct: 181 QQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAK---RRWEYENELSKVRNNYD 237
Query: 312 ASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
I SLKNQ E +H + KE++ QI+ E + E +
Sbjct: 238 EEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSL-----SEEIKR 292
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE-KFNFIE 430
++ +Q + ++ +E++I++ K T + + L+ EL + + E S K + +
Sbjct: 293 LKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDD 352
Query: 431 EIKTLKD-----ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL 485
KT++D E +++ I+ E K L E A ++ +++ + + + L++
Sbjct: 353 AAKTIQDKNKEIERLKQLIDKETNDRKC-LEDENARLQRVQYDLQKANSSATETINKLKV 411
Query: 486 RESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT 545
+E EL +L + ++ + V + ++T ++N+L + + +E L N LK A+
Sbjct: 412 QE--QELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL-NRLKRTASED 468
Query: 546 KEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+ +E +E ++ KE ++ + +L E ++KK S ++ R+ ++
Sbjct: 469 SCKRKKLEEE---LEGMRRSLKEQAIKITNLTQQL-EQASIVKKRSEDDLRQQRDVLDGH 524
Query: 606 RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR 665
+ R L Q + + NE + + E +
Sbjct: 525 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 584
Query: 666 QENEELTMTVAKQSSIIDKLKKDL 689
+ + LT + K+ ++++ ++L
Sbjct: 585 ERLQSLTENLTKEHLMLEEELRNL 608
Score = 73.7 bits (173), Expect = 2e-12
Identities = 127/639 (19%), Positives = 266/639 (41%), Gaps = 55/639 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI-----DFN 158
E+ ++ + +N + +++ D K+EI +L + + + + R++ N +
Sbjct: 104 EISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS 163
Query: 159 EIDRKLSKLRINNTNC---HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
EI +K L I +E NA E+ + I D I L+ + + +
Sbjct: 164 EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 223
Query: 216 DKQMELSSL-----EEVITVRDSLCKDLQ-EKLTSNELTLAETQQRLEMVKGHHALALEA 269
+ + ELS + EE+I++++ ++ K T ++LT+ Q+ E G+ A
Sbjct: 224 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTM----QKEEDTSGYRAQI--- 276
Query: 270 NESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL 329
+++ RE + E +K + Q + +V+++ + K S S + Q L+ + +
Sbjct: 277 -DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV 335
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
Q+ ++ ++ K L+ ++ +K K EI ER + + + + K ++
Sbjct: 336 TQMRTEESVR---YKQSLDDAAKTIQDKNK--EI---ERLKQLIDKETNDRKCLEDENAR 387
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF--IEEIKTLKDELIEKTINYE 447
++ ++Y L NS + +N LK + EL+ + ++ + + +T+KD+ I + ++
Sbjct: 388 LQRVQYDLQ---KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR---FQ 441
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVT-------RDIVHVLTLRLRESDSELEQLEDQVQ 500
N +L L +K +E N+ + + S + + + L+E ++ L Q++
Sbjct: 442 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 501
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK---EHTRIMEHNVT 557
+ K+ E++L ++ L+ +RE +E L + AL + + ++
Sbjct: 502 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 561
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
E Q ++ R L K E IE ++ L + + L EE+ R+ E
Sbjct: 562 RNEHFQKAIEDKSRSLNESKIE-IERLQSLTENLTKEHLMLEEELRNLRL--EYDDLRRG 618
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAK 677
+ +L S+L+ N R L E LRQE E+ +
Sbjct: 619 RSEADSDKNATILELR----SQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALE 674
Query: 678 QSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
S+ I + K Q +S V K L+ K +Q +
Sbjct: 675 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 713
Score = 44.8 bits (101), Expect = 0.001
Identities = 66/317 (20%), Positives = 140/317 (44%), Gaps = 27/317 (8%)
Query: 102 QDELVQAQDV---EIRNKDQTICEYNK---QIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+D+L Q +DV +R K +T E + ++E + ++ Q QE +K+ + I
Sbjct: 511 EDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI 570
Query: 156 D-----FNEIDRKLSKLRINNTNCHTEHNAVQGT---------DAEKV-SAMINDMRSRI 200
+ NE ++ +L+ N EH ++ D + S +D + I
Sbjct: 571 EDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI 630
Query: 201 IELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+EL + + +N + Q ++ L+ E +R + K ++ L ++ Q ++V
Sbjct: 631 LELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVV 690
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ--ENLKTKHNASIESL 317
+ +L ++ + + K L+ L+ +L+ K + ++ +V Q E K + +
Sbjct: 691 QERESLLVKIK--VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 748
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K Q +++ EA+ ++ S+ E+E + +IE +E +I E + S +E S
Sbjct: 749 KTQYSRKE-EAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 807
Query: 378 QQEKTIQYLEQEIKELK 394
Q E ++EI +L+
Sbjct: 808 QLETERSRYQREIDKLR 824
>AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb
protein.
Length = 1939
Score = 83.8 bits (198), Expect = 2e-15
Identities = 126/647 (19%), Positives = 270/647 (41%), Gaps = 58/647 (8%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+T + +I++ +EI EL K R+ + + +E+ + + L + E
Sbjct: 914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED--ECSELKKDIDDLELTLAKVEKE 971
Query: 178 HNAVQGTDAEKVSAMIN-DMRSRIIELEKKC--EALDNEVYDKQME---LSSLEEVITVR 231
+A + M D + EKK EA + D QME +++L + T
Sbjct: 972 KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKL 1031
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-----------NESIRREYKIE 280
+ DL+ L + + ++ ++G LA E+ NE ++++ + E
Sbjct: 1032 EQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKK-EFE 1090
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL--EQLHSQLII 338
+ L+ K+++E QA+ + Q+ +K + A IE L+ ++ E+ E+ S L
Sbjct: 1091 MSNLQGKIEDE-QALAMQL---QKKIK-ELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 339 KEQEMKAKLEQIEESASEKLKIC---EIQFEERSQSIQEHCSQQEKT-----------IQ 384
+ +E+ +LE+ + S ++++ E +F++ + ++E Q E T +
Sbjct: 1146 ELEEISERLEEAGGATSAQIELNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVA 1205
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
L ++I L+ + S+LK E+N+L + + +S K NF + +TL+D+L E
Sbjct: 1206 ELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKT 1265
Query: 445 NYENEKNKLN-LAVEKA--IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
E ++ +N L+ +KA E +F L +V L+ + ++E+L+ Q++
Sbjct: 1266 KEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI----LKSKAALTKEHTRIMEHNVT 557
T AK L + L + ++ + + +E +EA + K+ + + + T+ +
Sbjct: 1326 ETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQ 1385
Query: 558 LIESLQNVEKEAYRELGTIK------NELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E L+ +K+ + L + N +E K+ ++++ L +VE+ C
Sbjct: 1386 RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIA 1445
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVE----LSLLRQE 667
+ + A+L + E+ + E L L++E
Sbjct: 1446 LDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE 1505
Query: 668 NEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
N+ L ++ + I + K + + + K + L+ E +
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAE 1552
Score = 62.1 bits (144), Expect = 7e-09
Identities = 77/307 (25%), Positives = 138/307 (44%), Gaps = 37/307 (12%)
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
+E KTK + K + L+EK L Q + L ++ Q L EE + +K +
Sbjct: 858 EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIK-TK 916
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
IQ E + + + E +E+ + E+ K L+ ++ S+LK+++++L+ ++
Sbjct: 917 IQLEAKIKEVTERAEDEEE----INAELTAKKRKLE---DECSELKKDIDDLELTLAKVE 969
Query: 423 TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
EK ++K L +E+ L+ + K KEK + + H T
Sbjct: 970 KEKHATENKVKNLTEEMA-----------GLDETIAKLTKEKKALQEA--------HQQT 1010
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
L +L+ ED+V LT AK LE ++ + +L + C + + A L+
Sbjct: 1011 L------DDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA-KRKLEGDL 1063
Query: 543 ALTKEHTRIMEHN-VTLIESLQNVEKEAYRELGTIKNELIEDVELLK--KESNSQIKFLR 599
L +E T E++ L E L+ E E G I++E ++L K KE ++I+ L
Sbjct: 1064 KLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELE 1123
Query: 600 EEVEKKR 606
EE+E +R
Sbjct: 1124 EEIEAER 1130
Score = 58.4 bits (135), Expect = 8e-08
Identities = 101/519 (19%), Positives = 211/519 (40%), Gaps = 28/519 (5%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSK 166
Q + +++ K+ + +IED + QLQ+ +KEL + + I+ R ++
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 167 LRINNTNCHTEHNAVQGTDA-EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+ ++ + E + + +A SA I + R E +K L+ + ++L
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEFQKMRRDLEESTLQHEATAAALR 1197
Query: 226 ----EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN---ESIRREYK 278
+ + LQ E +E + + + + +A E + R +
Sbjct: 1198 KKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLE 1257
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNA------SIESLKNQMLKEKCEALEQL 332
+L +KTK +EE+Q +I++ + L T+ +++ +Q+ + K +Q+
Sbjct: 1258 DQLSEIKTK-EEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQI 1316
Query: 333 HSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQS---IQEHCSQQEKTIQY-- 385
E+E KAK L +SA + Q+EE ++ +Q S+ +
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
+ E ++ T +L L Q L + + + ++++ + + + L++E+ + I+
Sbjct: 1377 TKYETDAIQRTEEL-EEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMID 1435
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E N +A++K K++N F+ L+ + L S E L ++ + +A
Sbjct: 1436 VE-RSNAACIALDK--KQRN-FDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNA 1491
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
E + L T K N +E + E + K L K ++ L SL+
Sbjct: 1492 YEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEA 1551
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
E E G I +E + +K E + +I EE+++
Sbjct: 1552 EASLEHEEGKILRIQLE-LNQVKSEIDRKIAEKDEELDQ 1589
Score = 50.8 bits (116), Expect = 2e-05
Identities = 121/570 (21%), Positives = 238/570 (41%), Gaps = 57/570 (10%)
Query: 81 TKAPNSSIKKTLTCPKNKILPQDELVQAQD-VEIRNKDQTICEYNKQIEDYKNEIAQLQ- 138
TK +I++T + K L A++ VE N E KQ +NE+ L
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQ--RLQNEVEDLMI 1434
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
++ + A +F D+ L++ + E A Q ++ +S + +++
Sbjct: 1435 DVERSNAACIALDKKQRNF---DKVLAEWKQKYEETQAELEASQ-KESRSLSTELFKVKN 1490
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
E E L E + Q E+S L E I +L++ + +E Q LE
Sbjct: 1491 AYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEE 1550
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVDQ----ENLKTKHN 311
+ +LE E ++EL +K+++D EK + + K + E++++ +
Sbjct: 1551 AEA----SLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLD 1606
Query: 312 ASIESLKNQM-LKEKCEA-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-- 367
A I S + + +K+K E L ++ QL ++ L + + LK ++ ++
Sbjct: 1607 AEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI-LKDTQLHLDDAI 1665
Query: 368 RSQS-IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
R Q ++E + E+ ++ E++EL+ +L+ T +QEL + L T+
Sbjct: 1666 RGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT 1725
Query: 427 NFIEEIKTLK----------DELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTR 475
+ I K L+ ++++++ N E + K + A A + K + +TS + R
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 476 ------DIVHVLTLRLRESDS-ELEQLEDQVQMLTSAKEVLENEL-TTYKNTL------- 520
V L LRL E++ L+ + Q+Q L + LE+E+ + K+ +
Sbjct: 1786 MKKNMEQTVKDLQLRLGEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLR 1845
Query: 521 --NNTVRECD-EYKEALVNILKSKAALTKEHTRI--MEHNVTLIESLQNVEKEAYRELGT 575
V+E + +E NIL+ + + K T++ + E NV +R+L
Sbjct: 1846 KHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQH 1905
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKK 605
E E ++ + + N +++ EV K
Sbjct: 1906 ELEEAEERADIAESQVN-KLRVKSREVHTK 1934
>X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein.
Length = 1411
Score = 83.4 bits (197), Expect = 3e-15
Identities = 115/505 (22%), Positives = 229/505 (45%), Gaps = 70/505 (13%)
Query: 113 IRNKDQTICEYNKQIE-DYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKLSKLRIN 170
I + ++T E Q++ +N + + +E+ K L + SH ++ N + +L ++
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL--IQAQ 944
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV 230
NT E + +++ IN+++ + +K+ EAL E+ ++ + LE
Sbjct: 945 NTLKQNEK------EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN---- 994
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE-YKIELEALKTKLD 289
LQ++LT LA ++++ +++ ++ + E + ++ + Y E E L T+ D
Sbjct: 995 ------KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 290 ----EEKQAIISKCKVDQENLKTKHNASIESLKN-------------QMLKEKCEALEQL 332
EEK ++ + + N N I+ LK Q L+E+C+AL+ +
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
Query: 333 HSQLIIKEQEM---KAKLEQIEE-SASEKLKICEIQFEERSQSIQ--EHCSQQEKTIQYL 386
+ +KE+E+ K+KL +IEE ++ +I ++ E +S ++ + + + Q L
Sbjct: 1109 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL 1168
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
Q+ EL+ D + + ++QE N + KD++ E+ EE LK E IEK
Sbjct: 1169 IQQKLELQGKAD---SLKAAVEQEKRNQQILKDQVKKEE----EE---LKKEFIEKEAKL 1218
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
+E + + ++K E+N+ + ++ +T L L E + + +V L
Sbjct: 1219 HSEIKEKEVGMKK--HEENEAKLTMQIT-----ALNENLGTVKKEWQSSQRRVSELEKQT 1271
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
+ L E+ + T+ N DE + L LK + + K T+++E L L N
Sbjct: 1272 DDLRGEIAVLEATVQNNQ---DERRALLERCLKGEGEIEKLQTKVLE----LQRKLDNT- 1323
Query: 567 KEAYRELGTIKNEL-IEDVELLKKE 590
A +ELG L I+ + L ++
Sbjct: 1324 TAAVQELGRENQSLQIKHTQALNRK 1348
Score = 77.4 bits (182), Expect = 2e-13
Identities = 105/506 (20%), Positives = 215/506 (42%), Gaps = 25/506 (4%)
Query: 93 TCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKEL-ATKFRQS 151
T N++ ++ +Q Q ++ K + E +KQ ++ ++ Q+QE L A + R
Sbjct: 560 TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD--QVQEQKAHLRAAQDRVL 617
Query: 152 HNNIDFNEIDRKL--SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEA 209
NE++ +L SK +++ + + AE ++ +L+ +
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT------AQRADLQNHLDT 671
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR---LEMVKGHHALA 266
N + DKQ EL+ + + + +D QE + E L E +++ LE
Sbjct: 672 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ 731
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIIS-KCKVDQENLKTKHNASIESLKNQMLKEK 325
++ E+ E K E L +++Q + + + + + + I S L++K
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
EALE + Q + K++E K L+Q E+ S++ KI Q EE + IQ ++ +K
Sbjct: 792 SEALESI-KQKLTKQEEEKQILKQDFETLSQETKI---QHEELNNRIQTTVTELQKVKME 847
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
E + EL D + + LK + + + + + K LK +L + N
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E+ +L ++EK + ++ + L+ ++ + L++++ E +QL+ + L +
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA---ALTKEHTRIMEHNVTLIESL 562
E + ++ + L V + E + L L A A KE ++++N E
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN---YEKS 1024
Query: 563 QNVEKEAYRELGTIKNELIEDVELLK 588
Q K+ + ++EL+ + LK
Sbjct: 1025 QETFKQLQSDFYGRESELLATRQDLK 1050
Score = 75.8 bits (178), Expect = 5e-13
Identities = 134/630 (21%), Positives = 260/630 (41%), Gaps = 57/630 (9%)
Query: 100 LPQDELVQAQDVEIRNKDQTICEYN-KQIED-YKNEIAQLQEILKELATKFRQSHNNIDF 157
L D + Q +E + ++ +N KQ++D ++ + AQL + ++ +K+ + + +
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM-INDMRSRIIELEKKCEALDNEVYD 216
E +K+++L + E +Q E + I D+ EL + +DN +
Sbjct: 189 AE--QKVTRL---TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
++ E L++ CK LQ + S+E T++ Q R E+ KG +A+ E ++
Sbjct: 244 RERESEKLKDE-------CKKLQSQYASSEATIS--QLRSELAKGPQEVAVYVQEL--QK 292
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQLHS 334
K + L K + ++ K + D L+ KHN S KN L +K +QL S
Sbjct: 293 LKSSVNELTQKNQTLTENLLKK-EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+L E L +I SEK E +Q ++E S+ E Q+L+ E K+L+
Sbjct: 352 RLSASE----TSLHRIHVELSEK--------GEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
+ L+ E+N L + E + +K + EK ++ E + L
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 455 L---AVEKAIKEKNKFETSLSVTRD-----------IVHVLTLRLRESDSELEQLEDQVQ 500
L +E+ +KEK T L D + T +LRE+ ++LEQ+ Q+
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT----KEHTRIMEHNV 556
+ LE L K ++ +E ++ + A L K HT + E
Sbjct: 520 DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT-LQEQVT 578
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV-EKKRVLCEMXXXX 615
L E L+N + E++++ ++ +++ + + + ++ L V E L E
Sbjct: 579 QLTEKLKN-QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 616 XXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+ +LL+ AA ++ + EL+ + + +++T +
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 676 AKQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
+ +L+ L+ +Y K S+ +K+
Sbjct: 698 QDKQEHCSQLESHLK--EYKEKYLSLEQKT 725
Score = 74.5 bits (175), Expect = 1e-12
Identities = 115/514 (22%), Positives = 230/514 (44%), Gaps = 42/514 (8%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+ + + +Q+ D + ++++L+E LKE T + + +D + + + +T
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 178 HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRD---SL 234
D E+V I D +I LE + + + E L I + ++
Sbjct: 506 EAQ---NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA-------LKTK 287
LQEK + + + + ++L+ H A E +E K L A L+T
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 288 LDE-EKQAIISKCKVDQENL----KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQE 342
++E Q SK KV Q ++ KT+ S E+ K + L+ + L K+QE
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 343 MK---AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY-TLD 398
+ +L+Q+ +K + C Q E + +E E+ + LE +IK+L+ +L+
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCS-QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 399 LTNNQNS---DLKQE--LN-NLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNK 452
+ ++ DL+Q+ LN +L+ ELS + E + + + +L +K+ E+ K K
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L E+ K FET T+ L R++ + +EL++++ + + L + ++++
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 513 LTTYKNTLNNTVRECDEY----KEALVNILKS----KAALTKEHTRIMEHNVTLIESLQN 564
L+ ++L N+ E ++ K A++++ K+ K L + ++ L +SL+
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK 921
Query: 565 VEKEAYR----ELGTIKNELIEDVELLKKESNSQ 594
EKEA EL +++ +LI+ LK+ +
Sbjct: 922 -EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
Score = 48.0 bits (109), Expect = 1e-04
Identities = 61/280 (21%), Positives = 131/280 (46%), Gaps = 23/280 (8%)
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q+++A L++ E+ SE+LK E+ E+ Q +Q+ ++ + + E++ L+ L+
Sbjct: 93 QDLQASLKE-EKWYSEELKK-EL---EKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 401 NNQNSDLKQELNNLKNCKDELSTE----KFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
+N ++KQ + + +L+TE K + EE ++L++ +K E NK
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAAEQKVTRLTEELNKEATV 206
Query: 457 VE---KAIKEKNKFETSLSVTRDIVHVLTL---RLRESDSELEQLEDQVQMLTSAKEVLE 510
++ + ++ E + +++V V TL E + E E+L+D+ + L S E
Sbjct: 207 IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH------NVTLIESLQN 564
++ ++ L +E Y + L + S LT+++ + E+ + T +E N
Sbjct: 267 ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHN 326
Query: 565 VEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
E + + + T+ + ++ +L + S S+ R VE
Sbjct: 327 EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Score = 35.1 bits (77), Expect = 0.89
Identities = 59/254 (23%), Positives = 110/254 (43%), Gaps = 32/254 (12%)
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK------DELSTEKFNFIEEIKTLK 436
+ L QE+++L+ +L + +LK+EL + + D L T+ ++ ++
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 437 DELIEKTINYEN-----EKNKLNLAVEKA-IKEKNKFETSL-SVTRDIVHVLTLRLRESD 489
+E + N + E+ LA E A IK K E SL V LT L +
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 490 SELEQLEDQVQMLTSAKE--VLENELTTYKNTLNNTVRE--------CDEYKEALVNILK 539
+ ++ L+ ++ ++ VL+ EL + ++N E DE K+
Sbjct: 205 TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264
Query: 540 SKAALTKEHTRIM---EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE---SNS 593
S+A +++ + + + ++ LQ + K + EL T KN+ + + LLKKE +
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKL-KSSVNEL-TQKNQTLTE-NLLKKEQDYTKL 321
Query: 594 QIKFLREEVEKKRV 607
+ K E V KK +
Sbjct: 322 EEKHNEESVSKKNI 335
>AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransferase
9 protein.
Length = 978
Score = 83.4 bits (197), Expect = 3e-15
Identities = 126/561 (22%), Positives = 231/561 (41%), Gaps = 54/561 (9%)
Query: 82 KAPNSSIKKTLTCPKNKI-LPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
+A NS +K + ++ L Q+EL++ + N + E K+ QL+E
Sbjct: 215 EAENSDLKVNMAHRTSQFQLIQEELLE----KASNSSKLESEMTKKCSQLLTLEKQLEE- 269
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV-------------QGTDAE 187
K +A + N E+ K K+R TN +TEH + Q + E
Sbjct: 270 -KIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEME 328
Query: 188 K----VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVIT-----------VRD 232
K + A + + E EK L ++ KQ L SL+ ++T +D
Sbjct: 329 KQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKD 388
Query: 233 SLCKDLQEKLTSNELTLAETQQRLEMVKGH---HALALEAN-ESIRREYKIELEALKTKL 288
K LQ +++ + + + LE+ K H LE N E ++ K + E +
Sbjct: 389 EALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQ 448
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLE 348
E K S + ++N+ +H + Q + LE ++L + +++ +L+
Sbjct: 449 KELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ 508
Query: 349 QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+ ES++EKL+ + EE+ +S + + + L +++K +D + S ++
Sbjct: 509 KQRESSAEKLR----KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 564
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
+E+ +LK E F+ ++ I +EK N E KL + E + E +
Sbjct: 565 KEIMHLKR-DGENKAMHFSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 623
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
L H E S L QL++ +L A+ LE + TT K+ L +REC
Sbjct: 624 EVLETELQNAH------GELKSTLRQLQELRDVLQKAQLSLEEKYTTIKD-LTAELRECK 676
Query: 529 -EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV-EKEAYRELGTIKNE-LIEDVE 585
E ++ +L+ AL + + + + + + E E IK E +E E
Sbjct: 677 MEIEDEKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 736
Query: 586 LLKKESNSQIKFLREEVEKKR 606
L KE N QI+ L ++++ +
Sbjct: 737 LELKECNKQIESLNDKLQNAK 757
Score = 54.8 bits (126), Expect = 1e-06
Identities = 101/545 (18%), Positives = 226/545 (41%), Gaps = 38/545 (6%)
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
+V A + + R I++LE + E D + DK L + + VR + + + L E+
Sbjct: 7 EVMAQLTESRQSILKLESELENKDEILRDK-FSLMNENRELKVRVAAQNERLD-LCQQEI 64
Query: 248 TLAETQQR-LEMVKGHHALALEANESIRREYKIELEALKTKLD------EEKQAIISKCK 300
+ + R LE + L E K ++ + K D E + +IS+ +
Sbjct: 65 ESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR 124
Query: 301 V-----DQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESAS 355
+ + E K N + L ++ C ++ ++ + +K Q+ ES
Sbjct: 125 IKLAIKEAEIQKLHANLTANQLSQSLIT--CNDSQESSKLSSLETEPVKLGGHQVAESVK 182
Query: 356 EKLK-ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
++ + Q+E+ Q + + + +E E +LK + +Q +++EL
Sbjct: 183 DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 242
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK----FETS 470
+ +L +E ++ TL+ +L EK + Y + K N +E+ + EKN+ ET+
Sbjct: 243 ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAK-NAELEQELMEKNEKIRSLETN 301
Query: 471 LSVTRDIVHVLTLRLRESDSEL-EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE--C 527
++ + + + + ++ E +++E Q++ L + E + + + T++ ++ C
Sbjct: 302 INTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIIC 361
Query: 528 DEYK-EALVNIL-KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT----IKNELI 581
++ E+L +L +SK + KE+ + + + +++ + E R+L + K EL+
Sbjct: 362 KQHHLESLDRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV 420
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ L+ K L+++ E+ L + + +L L+
Sbjct: 421 LHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQ 480
Query: 642 NENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSV 701
E R L ++S L QE ++ ++ S +KL+K E+ + +
Sbjct: 481 QETIRNGELEDTQTKLEKQVSKLEQELQK------QRESSAEKLRKMEEKCESAAHEADL 534
Query: 702 LRKSL 706
R+ +
Sbjct: 535 KRQKV 539
Score = 43.6 bits (98), Expect = 0.003
Identities = 71/372 (19%), Positives = 169/372 (45%), Gaps = 33/372 (8%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K ++L + EL A E+++ + + E ++ + + + +K+L + R+ I
Sbjct: 622 KREVL-ETELQNAHG-ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 679
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ D K L ++ E N A +V+ + +R E+E+K L+ +
Sbjct: 680 E----DEKQELLEMDQAL--KERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE 733
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
++EL + I + ++ +E+L E + + +Q + +K + I R
Sbjct: 734 KSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLK----------KEIER 783
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
+ ++ +++ + E++Q I ++CK + +L K + E ++N + +Q+ +Q
Sbjct: 784 TQQ-RMKEMESVMKEQEQYIATQCK-EAIDLGQKLRLTREQVQNSHTELAEARHQQVQAQ 841
Query: 336 LIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS-IQE-HC-SQQEKTIQYLEQEIKE 392
I + + ++LE +++ + EK EE S ++E H ++ + I+ L E++
Sbjct: 842 REI--ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVES 899
Query: 393 LK--YTLDLTNNQNSDLKQEL--NNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
LK Y +++ ++Q + K ++ ++ K+ +L+ + +E+ K +E + N
Sbjct: 900 LKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQ----LEKAKLELEEAQDTVSNLHQ 955
Query: 449 EKNKLNLAVEKA 460
+ N +E A
Sbjct: 956 QVQDRNEVIEAA 967
>L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated protein
protein.
Length = 1410
Score = 83.0 bits (196), Expect = 3e-15
Identities = 105/467 (22%), Positives = 214/467 (45%), Gaps = 64/467 (13%)
Query: 113 IRNKDQTICEYNKQIE-DYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKLSKLRIN 170
I + ++T E Q++ +N + + +E+ K L + SH ++ N + +L ++
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL--IQAQ 944
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV 230
NT E + +++ IN+++ + +K+ EAL E+ ++ + LE
Sbjct: 945 NTLKQNEK------EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN---- 994
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE-YKIELEALKTKLD 289
LQ++LT LA ++++ +++ ++ + E + ++ + Y E E L T+ D
Sbjct: 995 ------KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 290 ----EEKQAIISKCKVDQENLKTKHNASIESLKN-------------QMLKEKCEALEQL 332
EEK ++ + + N N I+ LK Q L+E+C+AL+ +
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
Query: 333 HSQLIIKEQEM---KAKLEQIEE-SASEKLKICEIQFEERSQSIQ--EHCSQQEKTIQYL 386
+ +KE+E+ K+KL +IEE ++ +I ++ E +S ++ + + + Q L
Sbjct: 1109 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL 1168
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
Q+ EL+ D + + ++QE N + KD++ E+ EE LK E IEK
Sbjct: 1169 IQQKLELQGKAD---SLKAAVEQEKRNQQILKDQVKKEE----EE---LKKEFIEKEAKL 1218
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
+E + + ++K E+N+ + ++ +T L L E + + +V L
Sbjct: 1219 HSEIKEKEVGMKK--HEENEAKLTMQIT-----ALNENLGTVKKEWQSSQRRVSELEKQT 1271
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ L E+ + T+ N DE + L LK + + K T+++E
Sbjct: 1272 DDLRGEIAVLEATVQNNQ---DERRALLERCLKGEGEIEKLQTKVLE 1315
Score = 77.8 bits (183), Expect = 1e-13
Identities = 103/500 (20%), Positives = 215/500 (43%), Gaps = 25/500 (5%)
Query: 96 KNKILPQDELVQ-AQDVEIRNKDQTICEYN--KQIEDYKNEIAQLQEILKELATKFRQSH 152
KN L QDE+ Q ++V+ +++ + N Q+++ K + Q+ + L T + +
Sbjct: 569 KNHTL-QDEVTQLTENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 153 NNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDN 212
+ + NE K+S+L I TE + +A K +A D+++ + + +
Sbjct: 628 SQL--NESKEKVSQLDIQ-IKAKTE--LLLSAEAAK-TAQRADLQNHLDTAQNALQDKHQ 681
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
E+ +L + + + C L+ L + +Q+ E ++G ++ E+
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ----IKKLEA 737
Query: 273 IRREYKIELEALKTKLDEEKQAIIS-KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
E K E L +++Q + + + + + + I S L++K EALE
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
+ Q + K++E K L+Q E+ S++ KI Q EE + IQ ++ +K E +
Sbjct: 798 I-KQKLTKQEEEKQILKQDFETLSQETKI---QHEELNNRIQTTVTELQKVKMEKEALMT 853
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN 451
EL D + + LK + + + + + K LK +L + N E+
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+L ++EK + ++ + L+ ++ + L++++ E +QL+ + L + E +
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKA---ALTKEHTRIMEHNVTLIESLQNVEKE 568
++ + L V + E + L L A A KE ++++N E Q K+
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN---YEKSQETFKQ 1030
Query: 569 AYRELGTIKNELIEDVELLK 588
+ ++EL+ + LK
Sbjct: 1031 LQSDFYGRESELLATRQDLK 1050
Score = 72.9 bits (171), Expect = 4e-12
Identities = 115/514 (22%), Positives = 225/514 (43%), Gaps = 42/514 (8%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+ + + +Q+ D + ++++L+E LKE T + + +D + + + +T
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 178 HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKD 237
D E+V I + +I LE + + + E L I +
Sbjct: 506 EAQ---NDLEQVLRQIGEKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIR---REYKIELEA-------LKTK 287
L + N E Q E VK +A E++ +E K L A L+T
Sbjct: 563 LNQLQEKNHTLQDEVTQLTENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 288 LDE-EKQAIISKCKVDQENL----KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQE 342
++E Q SK KV Q ++ KT+ S E+ K + L+ + L K QE
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKHQE 682
Query: 343 MK---AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY-TLD 398
+ +L+Q+ +K + C Q E + +E E+ + LE +IK+L+ +L+
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCS-QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 399 LTNNQNS---DLKQE--LN-NLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNK 452
+ ++ DL+Q+ LN +L+ ELS + E + + + +L +K+ E+ K K
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L E+ K FET T+ L R++ + +EL++++ + + L + ++++
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 513 LTTYKNTLNNTVRECDEY----KEALVNILKS----KAALTKEHTRIMEHNVTLIESLQN 564
L+ ++L N+ E ++ K A++++ K+ K L + ++ L +SL+
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK 921
Query: 565 VEKEAYR----ELGTIKNELIEDVELLKKESNSQ 594
EKEA EL +++ +LI+ LK+ +
Sbjct: 922 -EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
Score = 64.9 bits (151), Expect = 1e-09
Identities = 128/629 (20%), Positives = 259/629 (41%), Gaps = 55/629 (8%)
Query: 100 LPQDELVQAQDVEIRNKDQTICEYN-KQIED-YKNEIAQLQEILKELATKFRQSHNNIDF 157
L D + Q +E + ++ +N KQ++D ++ + AQL + ++ +K+ + + +
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM-INDMRSRIIELEKKCEALDNEVYD 216
E +K+++L + E +Q E + I D+ EL + +DN +
Sbjct: 189 AE--QKVTRL---TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
++ E L++ K + + S+E T++ Q R E+ KG + + E ++
Sbjct: 244 RERESEKLKDE-------SKKFESQYASSEATIS--QLRSELSKGPQEVRVYVQEL--QK 292
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQLHS 334
K + L K + ++ K + D L+ KHN S KN L +K +QL S
Sbjct: 293 LKSSVNELTQKNQTLTENLLKK-EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+L E L +I SEK E +Q ++E S+ E Q+L+ E K+L+
Sbjct: 352 RLSASE----TSLHRIHVELSEK--------GEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
+ L+ E+N L + E + +K + EK ++ E + L
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 455 L---AVEKAIKEKNKFETSLSVTRD-----------IVHVLTLRLRESDSELEQLEDQVQ 500
L +E+ +KEK T L D + T +LRE+ ++LEQ+ Q+
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT--KEHTRIMEHNVT- 557
+ LE L K ++ +E ++ + A L +E ++ VT
Sbjct: 520 EKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQ 579
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV-EKKRVLCEMXXXXX 616
L E+++N + E++++ ++ +++ + + + ++ L V E L E
Sbjct: 580 LTENVKN-QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
Query: 617 XXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVA 676
+ +LL+ AA ++ + EL+ + + +++T +
Sbjct: 639 QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKHQELNKITTQLDQVTAKLQ 698
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
+ +L+ L+ +Y K S+ +K+
Sbjct: 699 DKQEHCSQLESHLK--EYKEKYLSLEQKT 725
Score = 52.0 bits (119), Expect = 7e-06
Identities = 65/295 (22%), Positives = 127/295 (43%), Gaps = 18/295 (6%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK ++ EK + L+Q ++ + A+L+ +E+ E+ + ++ ++
Sbjct: 107 EELKKEL--EKYQGLQQQEAKPDGLVTDSSAELQSLEQQL-EEAQTENFNIKQMKDLFEQ 163
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF--IEEI 432
+Q I ++ + E + + + + L +ELN +L TE IE++
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
LK EL++ +N + EK E KFE+ + + + L L + E+
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDESKKFESQYASSEATISQLRSELSKGPQEV 283
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTL-NNTVRECDEYKEALVNILKSKAALTKEHTRI 551
++Q L S+ NELT TL N +++ +Y + + ++ +++K++ +
Sbjct: 284 RVYVQELQKLKSS----VNELTQKNQTLTENLLKKEQDYTK--LEEKHNEESVSKKNIQA 337
Query: 552 MEHNVTL-IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
H L + LQ+ + L I EL E K E+ ++K EVE K
Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSE-----KGEATQKLKEELSEVETK 387
Score = 33.9 bits (74), Expect = 2.0
Identities = 60/254 (23%), Positives = 113/254 (44%), Gaps = 32/254 (12%)
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK------DELSTEKFNFIEEIKTLK 436
+ L QE+++L+ +L + +LK+EL + + D L T+ ++ ++
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 437 DELIEKTINYEN-----EKNKLNLAVEKA-IKEKNKFETSL-SVTRDIVHVLTLRLRESD 489
+E + N + E+ LA E A IK K E SL V LT L +
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 490 SELEQLEDQVQMLTSAKE--VLENELTTYKNTLNNTVRECDEYKEALVNILK-------- 539
+ ++ L+ ++ ++ VL+ EL + ++N E + E L + K
Sbjct: 205 TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDESKKFESQYAS 264
Query: 540 SKAALTKEHTRIME--HNVTL-IESLQNVEKEAYRELGTIKNELIEDVELLKKE---SNS 593
S+A +++ + + + V + ++ LQ + K + EL T KN+ + + LLKKE +
Sbjct: 265 SEATISQLRSELSKGPQEVRVYVQELQKL-KSSVNEL-TQKNQTLTE-NLLKKEQDYTKL 321
Query: 594 QIKFLREEVEKKRV 607
+ K E V KK +
Sbjct: 322 EEKHNEESVSKKNI 335
>BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2,
skeletal muscle, adult protein.
Length = 1941
Score = 83.0 bits (196), Expect = 3e-15
Identities = 126/627 (20%), Positives = 263/627 (41%), Gaps = 56/627 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S +KK + + + ++ A + +++N + + ++ I E LQE ++
Sbjct: 954 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1013
Query: 146 TKFRQSHNNIDFNEIDRKLSKL--RINNTNCHTEHNAVQGTDAEKVSAMIN-DMR---SR 199
+ + + N + + KL ++++ E D E+ + D++
Sbjct: 1014 DDLQAEEDKV--NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I+++E + + LD ++ K+ E+S+L+ I +L LQ+K+ + + E ++ +E
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A A + + RE + E L + +++++++A K + D E +H
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1191
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + K++I ++ +
Sbjct: 1192 EATAATLR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEMKMEIDDL--ASNVE 1242
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
++ + EK + LE ++ ELK + +DL + L+ E S + ++
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ----LD 1298
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + + +L +E+ IK KN +L +R H L + +
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR---HDCDLLREQYEE 1355
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E + + L+ A + T Y+ E +E K+ L L++ +EH
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA----AEEHVE 1411
Query: 551 IMEHNVTLIE-SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+ +E + Q ++ E + ++ L KK+ N K L E +K C
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD-KILAEWKQK----C 1466
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E S+ +L +++N Y +L E L+QE
Sbjct: 1467 E-------ETHAELEASQKEARSLGTELFKIKN---AYEESLDQLETLKRENKNLQQEIS 1516
Query: 670 ELTMTVA---KQSSIIDKLKKDLEQSQ 693
+LT +A K+ ++K+KK +EQ +
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEK 1543
Score = 63.3 bits (147), Expect = 3e-09
Identities = 84/431 (19%), Positives = 190/431 (44%), Gaps = 21/431 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + + K + +K + ++ L+ K ++ + L+ + EA E
Sbjct: 850 ETEKEMATMKEEFQKIKDEL-AKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A ++ +I + + + +++ CS+ +K I LE +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +E+ L +L+ EK E + D+L + E++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE----EDKV 1023
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N L A K ++ + E SL + + L R+ + +L+ ++ + + + K+ L+
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+L + ++N + ++ ++AL L+ K KE +E IE+ + +A
Sbjct: 1084 EKLKKKEFEISNLQSKIED-EQALGIQLQKK---IKELQARIEELEEEIEAERASRAKAE 1139
Query: 571 RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
++ + EL E E L++ + + +++ +M + L
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 631 AQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM---TVAKQSSIIDKLKK 687
+ A ++ L E+ L E S ++ E ++L TV+K ++K+ +
Sbjct: 1200 KKHADSVAEL---GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 688 DLEQSQYTPKS 698
LE KS
Sbjct: 1257 TLEDQLSELKS 1267
Score = 61.7 bits (143), Expect = 9e-09
Identities = 109/521 (20%), Positives = 215/521 (41%), Gaps = 35/521 (6%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T ++ED ++ + L K R D+
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN---------FDK 1457
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
L++ + H E A Q +A + + +++ E + E L E + Q E+S
Sbjct: 1458 ILAEWKQKCEETHAELEASQ-KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E I +L++ E E Q LE + +LE E ++EL
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA----SLEHEEGKILRIQLELN 1572
Query: 283 ALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCEA-LEQLH 333
+K+++D EK I + K + E++++ +A I S + + LK+K E L ++
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 334 SQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE--RSQS-IQEHCSQQEKTIQYLEQEI 390
QL M A+ + + LK +I ++ RSQ ++E + E+ L+ EI
Sbjct: 1633 IQLN-HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN-- 448
+EL+ TL+ T +QEL + L T+ + I K L+ ++ + E+
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDIL 1751
Query: 449 -EKNKLNLAVEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELE-QLEDQVQMLT 503
E +KAI + L +D H+ ++ + ++ +L+ +L++ Q+
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
+ +L L V + V L+ KE T E + I LQ
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQ 1871
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + ++ + K + E+ E + ++ + L+ E+E+
Sbjct: 1872 DLVDKLQAKVKSYKRQ-AEEAEEQSNTNLAKFRKLQHELEE 1911
>AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa
protein.
Length = 1941
Score = 83.0 bits (196), Expect = 3e-15
Identities = 126/627 (20%), Positives = 263/627 (41%), Gaps = 56/627 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S +KK + + + ++ A + +++N + + ++ I E LQE ++
Sbjct: 954 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1013
Query: 146 TKFRQSHNNIDFNEIDRKLSKL--RINNTNCHTEHNAVQGTDAEKVSAMIN-DMR---SR 199
+ + + N + + KL ++++ E D E+ + D++
Sbjct: 1014 DDLQAEEDKV--NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I+++E + + LD ++ K+ E+S+L+ I +L LQ+K+ + + E ++ +E
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A A + + RE + E L + +++++++A K + D E +H
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1191
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + K++I ++ +
Sbjct: 1192 EATAATLR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEMKMEIDDL--ASNVE 1242
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
++ + EK + LE ++ ELK + +DL + L+ E S + ++
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ----LD 1298
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + + +L +E+ IK KN +L +R H L + +
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR---HDCDLLREQYEE 1355
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E + + L+ A + T Y+ E +E K+ L L++ +EH
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA----AEEHVE 1411
Query: 551 IMEHNVTLIE-SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+ +E + Q ++ E + ++ L KK+ N K L E +K C
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD-KILAEWKQK----C 1466
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E S+ +L +++N Y +L E L+QE
Sbjct: 1467 E-------ETHAELEASQKEARSLGTELFKIKN---AYEESLDQLETLKRENKNLQQEIS 1516
Query: 670 ELTMTVA---KQSSIIDKLKKDLEQSQ 693
+LT +A K+ ++K+KK +EQ +
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEK 1543
Score = 63.3 bits (147), Expect = 3e-09
Identities = 84/431 (19%), Positives = 190/431 (44%), Gaps = 21/431 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + + K + +K + ++ L+ K ++ + L+ + EA E
Sbjct: 850 ETEKEMATMKEEFQKIKDEL-AKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A ++ +I + + + +++ CS+ +K I LE +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +E+ L +L+ EK E + D+L + E++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE----EDKV 1023
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N L A K ++ + E SL + + L R+ + +L+ ++ + + + K+ L+
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+L + ++N + ++ ++AL L+ K KE +E IE+ + +A
Sbjct: 1084 EKLKKKEFEISNLQSKIED-EQALGIQLQKK---IKELQARIEELEEEIEAERASRAKAE 1139
Query: 571 RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
++ + EL E E L++ + + +++ +M + L
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 631 AQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM---TVAKQSSIIDKLKK 687
+ A ++ L E+ L E S ++ E ++L TV+K ++K+ +
Sbjct: 1200 KKHADSVAEL---GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 688 DLEQSQYTPKS 698
LE KS
Sbjct: 1257 TLEDQLSELKS 1267
Score = 61.7 bits (143), Expect = 9e-09
Identities = 109/521 (20%), Positives = 215/521 (41%), Gaps = 35/521 (6%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T ++ED ++ + L K R D+
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN---------FDK 1457
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
L++ + H E A Q +A + + +++ E + E L E + Q E+S
Sbjct: 1458 ILAEWKQKCEETHAELEASQ-KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E I +L++ E E Q LE + +LE E ++EL
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA----SLEHEEGKILRIQLELN 1572
Query: 283 ALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCEA-LEQLH 333
+K+++D EK I + K + E++++ +A I S + + LK+K E L ++
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 334 SQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE--RSQS-IQEHCSQQEKTIQYLEQEI 390
QL M A+ + + LK +I ++ RSQ ++E + E+ L+ EI
Sbjct: 1633 IQLN-HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN-- 448
+EL+ TL+ T +QEL + L T+ + I K L+ ++ + E+
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDIL 1751
Query: 449 -EKNKLNLAVEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELE-QLEDQVQMLT 503
E +KAI + L +D H+ ++ + ++ +L+ +L++ Q+
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
+ +L L V + V L+ KE T E + I LQ
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQ 1871
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + ++ + K + E+ E + ++ + L+ E+E+
Sbjct: 1872 DLVDKLQAKVKSYKRQ-AEEAEEQSNTNLAKFRKLQHELEE 1911
>AL139421-4|CAI22511.1| 720|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 720
Score = 81.8 bits (193), Expect = 8e-15
Identities = 116/503 (23%), Positives = 225/503 (44%), Gaps = 49/503 (9%)
Query: 116 KDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKL-RINNTNC 174
KDQ NKQ Y+ E +L ++EL TK Q I+ D K++ R +
Sbjct: 222 KDQNQHTMNKQ---YEKERQRLVTGIEELRTKLIQ----IEAENSDLKVNMAHRTSQFQL 274
Query: 175 HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSL 234
E + +++ K+ + + S+++ LEK+ E + + LE+ + + L
Sbjct: 275 IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQL 334
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQA 294
K Q+ E T++ QQ + + K HH LE+ + + E K E++ K DE +A
Sbjct: 335 EKKDQQ-FKEQEKTMSMLQQDI-ICKQHH---LESLDRLLTESKGEMKKENMKKDEALKA 389
Query: 295 IISKCKVDQENLKTKH-NASIESLKNQML---------KEKCEA-LEQLHSQLIIKEQEM 343
+ ++ V +E +K + ++++E K +++ KEK E L++ ++ ++E+
Sbjct: 390 LQNQ--VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 447
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHC---SQQEKTIQYLEQEIKELKYTLDLT 400
K K ++E+ SE+ I + +++ Q +Q+ + E T LE+++ +L+ L
Sbjct: 448 KIKNHSLQET-SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ 506
Query: 401 NNQNSD-LKQELNNLKNCKDELSTEKFNFIE------EIKTLKDELIEKTINYENEKNKL 453
+++ L++ ++ E ++ IE ++K D+ E+ E E L
Sbjct: 507 RESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL 566
Query: 454 NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
E ++ + L T+ + T ++E + E ++ +EVLE EL
Sbjct: 567 KRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETEL 626
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYREL 573
L +T+R+ E ++ L KA L+ +E T I+ L +E E+
Sbjct: 627 QNAHGELKSTLRQLQELRDVL-----QKAQLS------LEEKYTTIKDLTAELRECKMEI 675
Query: 574 GTIKNELIEDVELLKKESNSQIK 596
K EL+E + L KE N ++K
Sbjct: 676 EDKKQELLEMDQAL-KERNWELK 697
Score = 70.5 bits (165), Expect = 2e-11
Identities = 138/633 (21%), Positives = 272/633 (42%), Gaps = 80/633 (12%)
Query: 124 NKQIED----YKNEIAQLQEILKELATKFRQSHNN---------IDFNEIDRKLSKLRIN 170
NK++++ YK+E+ EILKE + ++ +NN + +E+ +L++ R +
Sbjct: 4 NKRLQERCGLYKSEL----EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQS 59
Query: 171 NTNCHTEHNAVQGTDAEKVSAMIN--DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI 228
+E +K S M +++ R+ ++ + E+ ++EL SLE++I
Sbjct: 60 ILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKII 119
Query: 229 TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL-EANESIRREYKIEL---EAL 284
+ L+ +L + L++ Q K + EAN+ + E +I+L EA
Sbjct: 120 SQLP-----LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 174
Query: 285 KTKL------DEEKQAIISKCKVDQENLKTKH---------NASIESLKNQMLKEKCEAL 329
KL ++ Q++I+ C QE+ K +ES+K+Q +
Sbjct: 175 IQKLHANLTANQLSQSLIT-CNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQY 233
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E+ +L+ +E++ KL QIE S+ LK+ + Q IQE ++ LE E
Sbjct: 234 EKERQRLVTGIEELRTKLIQIEAENSD-LKVNMAHRTSQFQLIQEELLEKASNSSKLESE 292
Query: 390 I-KELKYTLDLTNN-------------QNSDLKQELNNLKNCKDELSTEKFNFIEE-IKT 434
+ K+ L L +N++L+QEL + + E ++F E+ +
Sbjct: 293 MTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL--MLEAQLEKKDQQFKEQEKTMSM 350
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
L+ ++I K + E+ L + + KE K + +L ++ V T+++R+ DS LE
Sbjct: 351 LQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEI 410
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
++++ + + LE ++ L E ++ L I T E I++H
Sbjct: 411 CKEELVLHLNQ---LEGNKEKFEKQLKKKSEEVYCLQKEL-KIKNHSLQETSEQNVILQH 466
Query: 555 NVTLIESLQNVEKEAYR--ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX 612
TL + Q +++E R EL + +L + V L++E Q + E++ K CE
Sbjct: 467 --TLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCE-- 522
Query: 613 XXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELT 672
R + + +++ E ++Y + E+ L+++ E
Sbjct: 523 -----SAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS---KMEKEIMHLKRDGENKA 574
Query: 673 MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
M +++ I+D+ K +LE+ K L+ S
Sbjct: 575 MHLSQLDMILDQTKTELEKKTNAVKELEKLQHS 607
Score = 39.9 bits (89), Expect = 0.031
Identities = 68/371 (18%), Positives = 161/371 (43%), Gaps = 33/371 (8%)
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK--DELST 423
E+ ++ +QE C + ++ L++++++LK N N K + +KN + +L+
Sbjct: 1 EKENKRLQERCGLYKSELEILKEKLRQLK-----EENNNGKEKLRIMAVKNSEVMAQLTE 55
Query: 424 EKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
+ + ++ L KDE++ + NE +L + V A E+ L + + +
Sbjct: 56 SRQSILKLESELENKDEILRDKFSLMNENRELKVRV-AAQNER------LDLCQQEIESS 108
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ LR + + QL + ++ + + +++++ N + + C E + +++ L+ K
Sbjct: 109 RVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI-GCCEANKLVISELRIK 167
Query: 542 AALTKEHTRIMEHNVTLIESLQNV----EKEAYRELGTIKNELIE----DVELLKKESNS 593
A+ + + + N+T + Q++ + + +L +++ E ++ VE + K+ N
Sbjct: 168 LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESV-KDQNQ 226
Query: 594 QIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS--RVLLAQAAADLSRLENE-NERYXXX 650
+ E E++R++ + S +V +A + ++ E E+
Sbjct: 227 HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNS 286
Query: 651 XXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGK 710
+ + S L ++L + SSI K +LEQ + L K + K
Sbjct: 287 SKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAK-NAELEQELML---EAQLEKKDQQFK 342
Query: 711 ENMQTISPLRE 721
E +T+S L++
Sbjct: 343 EQEKTMSMLQQ 353
>BX538186-1|CAD98058.1| 971|Homo sapiens hypothetical protein
protein.
Length = 971
Score = 81.0 bits (191), Expect = 1e-14
Identities = 115/542 (21%), Positives = 249/542 (45%), Gaps = 40/542 (7%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
++L K K + Q Q+ +R +TI + +++ ++E L + ++L T
Sbjct: 155 ESLQASKEKEADLRKEFQGQEAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 211
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA---EKVSAMINDM---RSRIIEL 203
+ NN+ + ++L + ++H V+ A E++ +D+ S I L
Sbjct: 212 IAENNVQV--LQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 269
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ + + D + E S + E ++ + L+ K S L + QQ LE+ K +
Sbjct: 270 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS--LDEEQKQQILELEKKVN 327
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
EA + + Y+ EL+ L+++L+EE + E L KH+ +IE++ + ++
Sbjct: 328 ----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR 383
Query: 324 EKCEA---LEQLHS--QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQ 373
+K + LE+ H+ +L ++E +++ +LE ++E +KL EI ++ + +
Sbjct: 384 DKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLDTANQEIGHLQDMVRKSE 443
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
+ E I L+ + L+ LDLT + LK+ + L N + EL E+ E I
Sbjct: 444 QGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIA 500
Query: 434 TLKDE---LIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES- 488
+K+E ++K + K NL E ++E+ + + + +L L+ RE
Sbjct: 501 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 560
Query: 489 ---DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL 544
DS +++ED + ++ K+ LE +L+ + +L + + ++ L L+ +
Sbjct: 561 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH 620
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ H + E +V ++++ +++ R L ++ + +++ LK ++ LR E+E
Sbjct: 621 QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGLRIEME 680
Query: 604 KK 605
++
Sbjct: 681 QE 682
Score = 55.6 bits (128), Expect = 6e-07
Identities = 93/482 (19%), Positives = 207/482 (42%), Gaps = 38/482 (7%)
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVDQENLK 307
E Q+ L+ + H A + E +++E+E+L L+E E++ +I + +
Sbjct: 77 EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ 136
Query: 308 TKHNASIESLKNQML--KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ- 364
+ + +++LK L E +A ++ + L + Q +A L + +L++ + +
Sbjct: 137 SFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEA 196
Query: 365 --FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++ Q +Q + E +Q L++++ + K +++ +++ EL + + +
Sbjct: 197 GSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQA 256
Query: 423 TEKFNFIEEIKTLKDELI--EKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
++ I L+ + E TI + E+EK+++N + + ++E+ F S + + D
Sbjct: 257 SDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-LEEERAFLRSKTQSLD--- 312
Query: 480 VLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
E ++ +LE +V + + +E E EL ++ L V + +E + L
Sbjct: 313 ------EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEEL 366
Query: 539 --KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
K A+ H+ + L L+ + L KN+L +++E LK+ ++
Sbjct: 367 AWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLD 426
Query: 597 FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----NERYXXXXX 652
+E+ L +M + L+A RL+NE +
Sbjct: 427 TANQEIGH---LQDM----VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 479
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSI-IDKLKKDLE--QSQYTPKSPSVLRKSLKVG 709
++ EL RQ++EE + ++ + +DK+ DLE ++ + S LR+ L++
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQ 539
Query: 710 KE 711
E
Sbjct: 540 HE 541
Score = 45.2 bits (102), Expect = 8e-04
Identities = 64/307 (20%), Positives = 142/307 (46%), Gaps = 23/307 (7%)
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAE-TQQRL 256
S++++L+ + + + + K++E L ++ ++ +L L + TS + A+ TQ+R
Sbjct: 549 SQLLQLKDREKNAARDSWQKKVE-DLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQ 607
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
+ + L + + + + + A +T ++EEK+ + + + +L+ KH+A ++S
Sbjct: 608 RLTQELEELEEQHQQRHKSLKEAHVLAFQT-MEEEKE---KEQRALENHLQQKHSAELQS 663
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
LK+ E++E L ++ EQE++ ++E+ K + ++ E Q
Sbjct: 664 LKDAHR----ESMEGLRIEM---EQELQTLRFELEDEG--KAMLASLRSELNHQHAAAID 714
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQN-------SDLKQELNNLKNCKDELSTEKFNFI 429
+ Q L EL+ ++D++ Q+ +DL++EL + ++ EL E +
Sbjct: 715 LLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHRISELDKEVQHLH 774
Query: 430 EEIKTLKDELIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E I L EL K +++ N + + ++EK S ++ L L E
Sbjct: 775 ENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTER 834
Query: 489 DSELEQL 495
D +++L
Sbjct: 835 DQIIKKL 841
>AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein.
Length = 1870
Score = 81.0 bits (191), Expect = 1e-14
Identities = 134/621 (21%), Positives = 257/621 (41%), Gaps = 43/621 (6%)
Query: 85 NSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYK---NEIAQLQEIL 141
N +KKTL KN + L + E D+ E + +E K ++AQLQ
Sbjct: 672 NRKLKKTLDSFKNLTFQLESL----EKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 142 KELATKFRQSHNNIDFNEID-RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
KEL ++ Q ++ + +K +L ++ E+ +Q T E + I + S +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT-LENSNKKIQQLESEL 786
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE + + L + + ++ LE++ SL ++ + L ++ L + +RL
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ-LEKDKKQLEKENKRLRQQA 845
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
LE N + E + L ++ K++ + ++++EN + A+I+
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 321 MLKEKCEALEQLHSQLIIKEQE-MKAKLEQIEESASEKLKICEIQFEERSQSIQEHC-SQ 378
L+E + E+L +Q + + E + +LE+I + E+L E ++R + ++ S
Sbjct: 906 TLREDLVS-EKLKTQQMNNDLEKLTHELEKIGLN-KERLLHDEQSTDDRYKLLESKLEST 963
Query: 379 QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE 438
+K+++ E++I L+ L+ + N N L+QEL +K N+ E +K +DE
Sbjct: 964 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK----------NY-EALKQRQDE 1012
Query: 439 --LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+++ + E NK ++ +E K + L L + ++L+QLE
Sbjct: 1013 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1072
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
Q L + ++L + T NT + K + N + L + T +M N
Sbjct: 1073 TQNNNLQA--QILALQRQTVSLQEQNTTLQTQNAKLQVEN-----STLNSQSTSLMNQNA 1125
Query: 557 TLI---ESLQNVEKEAYRE---LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
L+ SL+N + +E L ++ + LI+D E L+ Q + K L
Sbjct: 1126 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS 1185
Query: 611 MXXXXXXXXXXXXXXSRVLLAQAA--ADLSR-LENENERYXXXXXXXXSLVVELSLLRQE 667
LL Q DL + L+ E E+ ++ E L E
Sbjct: 1186 AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1245
Query: 668 NEELTMTVAKQSSIIDKLKKD 688
N+ L T ++ + L+ D
Sbjct: 1246 NDRLNHTYSQLLKETEVLQTD 1266
Score = 72.9 bits (171), Expect = 4e-12
Identities = 132/669 (19%), Positives = 293/669 (43%), Gaps = 65/669 (9%)
Query: 73 ATPKAFKITKAPNSSIKKTLTCPKNKILPQDEL--VQAQDVEIRNKDQTICEYNKQIEDY 130
A K ++ + ++ L C + + EL +Q +++ + + ++ Y +++
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTD 185
+ + ++ ++ E++ ++++ ++I+F + ++ +L+ +N T E + ++GT
Sbjct: 316 REKAVRVDKLESEVS-RYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLE-DQLEGTR 371
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
A S ++++ ++L+ K ++ E D++ +EE +T+ + + + E L
Sbjct: 372 AR--SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 245 N-ELT-LAETQQRLEMVK---GHHALALEANESIRREYKIE-----LEALKTKLDEEKQA 294
EL ++ T + E + GH L ++ ++ E + + +E L+T +D +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEE 352
K+++EN + + +E L+N++++EK + + L L+ ++ +++ +E + E
Sbjct: 490 ASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 353 SASEKLKICEIQFE----------ERSQ-SIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ ++KI E + E +RSQ S + EK + L + IKE L
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+ +K+EL + K K E + E N + ++ + L +K N + K+ A+E+
Sbjct: 608 FEKRQIKKELEHYKE-KGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQEN 665
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL-EDQVQMLTSAKEVLENELTTYKNTL 520
E + L T D LT +L + E QL E+ +++ + + + + + L
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 521 NNTVRECDEYKEALVNILK-SKAALTKEHTRIMEHNVTLIES--LQNVEKEAYRELGTIK 577
N +E + KE L L+ KA+ K + + IE+ LQ + + +++ ++
Sbjct: 726 EN--KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 578 NELIEDVELLKKESNSQIKFLR------EEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLA 631
+EL +D+E+ + ++ L+ E++EK+ E L
Sbjct: 784 SEL-QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 632 QAA-----------ADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
Q A + LE EN+ V L L +EN+EL
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 681 IIDKLKKDL 689
+ L++DL
Sbjct: 903 TLVTLREDL 911
Score = 71.3 bits (167), Expect = 1e-11
Identities = 129/635 (20%), Positives = 272/635 (42%), Gaps = 68/635 (10%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ D K +I +L++ L+E + ++ EI+ L +L+ N N ++ + +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE--LKRLQQENMNLLSDARSARMYR 309
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
E ++ +R + + ++K L++EV + L +E K E+L +
Sbjct: 310 DE-----LDALREKAVRVDK----LESEVSRYKERLHDIE--------FYKARVEELKED 352
Query: 246 ELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQ 303
L ET+ LE ++G A + + +E + + LK KL D E + + + K+++
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEE 407
Query: 304 ENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
+ N ++E + Q + E LEQ+ + E K+ ++ E S +L
Sbjct: 408 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 361 CEIQFEERSQSIQEHCSQQEKT------IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E++ + +++++E + + I +E+E + L +++ N+ KQ L N
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+N +L EK + I+TL++ + E E LN V +++++++ V
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS-SLRQRSQISAEARV- 582
Query: 475 RDIVH---VLTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECD 528
+DI +L ++E+ S+L ++E + + + E + + +N L++ +E +
Sbjct: 583 KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE 642
Query: 529 EYKEALVNI---LKSKAALTKEHTRIMEHNVTLIESL----------QNVEKEAYRELGT 575
++ + N+ + AL +E++ + N L ++L +++EKE +L
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN-SQLDE 701
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAA 635
EL +VE LK S + E E + ++ R+ ++
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 636 DLSR------LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
D+ LEN N++ L +E L++ EEL ++ +K+ ++K K L
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL 820
Query: 690 EQ-SQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
EQ + K L K K ++ + E N
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Score = 58.8 bits (136), Expect = 6e-08
Identities = 101/524 (19%), Positives = 222/524 (42%), Gaps = 40/524 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF---- 157
+D ++ +V+I N ++ +K+I YK +L+E+ KE +++ +I
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 158 --NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDMRSRIIELEKKCEA-LDNE 213
+ + KL ++NN H + G + E++ R LE K E+ L
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTS---NELTLAETQQRLEMVKGHHALALEAN 270
+ K+ ++++LE + + + L+++L + N L + Q MV+ ++ E N
Sbjct: 968 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1027
Query: 271 ESIRREYKIELEALKTK---LDEEK-----QAIISKCKVDQENLKTKHN---ASIESLKN 319
+ R + E LK K ++ E+ QA K + L+T++N A I +L+
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087
Query: 320 QM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
Q L+E+ L+ +++L ++ + ++ + ++ L I + E ++S+ +
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL-IQQSSLENENESVIKERE 1146
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
+ L ++ ++L+ + ++ L + LK+ L E +++ +
Sbjct: 1147 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH----RDLEDRYN 1202
Query: 438 ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+L+++ E+ + L + EK + E ET + ++ E ++L
Sbjct: 1203 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHET-----------VAAEYKKLCGENDRLNH 1251
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
L EVL+ + K+ LNN+ E + + + L T++
Sbjct: 1252 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1311
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREE 601
L + N+E+E L I+ ++++ LL++ S+ F E+
Sbjct: 1312 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQ 1355
Score = 54.4 bits (125), Expect = 1e-06
Identities = 84/433 (19%), Positives = 192/433 (44%), Gaps = 38/433 (8%)
Query: 73 ATPKAFKITKAP-NSSIKKTLTCPKNKILPQDELVQAQ---DVEIRNKDQTI---CEYNK 125
+T +K+ ++ S++KK+L + KI + ++ + ++R + +T+ E K
Sbjct: 948 STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNI-DFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
Q +D + + I E R+S + ++ +L ++ NN E A++ T
Sbjct: 1008 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK-T 1066
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+++ N+++++I+ L+++ +L + Q + + L+ + +S L +
Sbjct: 1067 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK---CKV 301
+ + + E V +S+ ++++ +LE L + E +++ISK K
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KLELLHERQASEYESLISKHGTLKS 1185
Query: 302 DQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
+NL+ +H +E NQ+LK+K + LE L L +++++M + + E A+E K+C
Sbjct: 1186 AHKNLEVEHR-DLEDRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
Query: 362 E------------------IQFEERSQSIQEHCSQQEKT-----IQYLEQEIKELKYTLD 398
+Q + ++ + S+ E+T L+++ ++L T
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVE 458
NNQ L Q NL+ L + + + +TL ++ +E + E+ + +
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN 1363
Query: 459 KAIKEKNKFETSL 471
+ ++K K E +
Sbjct: 1364 ELRRQKEKLEEKI 1376
Score = 50.8 bits (116), Expect = 2e-05
Identities = 97/404 (24%), Positives = 174/404 (43%), Gaps = 46/404 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V+ + ++ + Q + KQ+E N + Q Q + + T Q N + + +
Sbjct: 1050 VERNNATLQAEKQALKTQLKQLETQNNNL-QAQILALQRQTVSLQEQNTT----LQTQNA 1104
Query: 166 KLRINNTNCHTEHNAVQGTDAEKV---SAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
KL++ N+ +++ ++ +A+ + S++ N+ S I E E D+ + D + +L
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KLE 1163
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E R + E L S TL + LE+ H L N+ ++++ ++E
Sbjct: 1164 LLHE----RQA---SEYESLISKHGTLKSAHKNLEVE--HRDLEDRYNQLLKQKGQLEDL 1214
Query: 283 ALKTKLDEEKQAIISKCK--VDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
K+++EK + +K V E K N + +Q+LKE E L+ H L K
Sbjct: 1215 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNL--K 1271
Query: 340 EQEMKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+KLEQ E+ KLK Q + S + C + LE+E + L +
Sbjct: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1331
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTIN----YE---- 447
QN L ++ N+++ KD E+ +I+ E++ K++L EK ++ Y+
Sbjct: 1332 TLMLQNRTLLEQ--NMES-KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPP 1388
Query: 448 -NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
N + L + K IK K + R+ LTL SDS
Sbjct: 1389 RRRGNWITLKMRKLIKSKK------DINRERQKSLTLTPTRSDS 1426
>U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein.
Length = 1017
Score = 80.6 bits (190), Expect = 2e-14
Identities = 120/620 (19%), Positives = 256/620 (41%), Gaps = 33/620 (5%)
Query: 80 ITKAPNSSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
I A NS + +TL ++ ++ + V +R++ + + KQI++ + ++++L
Sbjct: 77 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL---TKQIQEKQGQLSELD 133
Query: 139 EILKELATKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
++L ++ + I E + ++ N E A D E + A +
Sbjct: 134 KLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 193
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
I E + ++ E ++E +++ ++ + L + E + +
Sbjct: 194 PPIEEEHQLRNSI--EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 251
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
HA ALEA S K E+E LK K++ Q++ ++D ++++ E L
Sbjct: 252 RTNQEHA-ALEAENS-----KGEVETLKAKIEGMTQSLRG-LELDVVTIRSEK----EDL 300
Query: 318 KNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH 375
N++ KE + LE ++S QE + + Q++E +S +++ + Q + + Q
Sbjct: 301 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQP- 359
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTL 435
C +K + EQ + L+L + + L Q L+ KN L + I+E++
Sbjct: 360 CIMTKKPVSAKEQNLSSQVECLEL---EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 416
Query: 436 KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL 495
K +L +K KN++ E+ + + ++ E + ++ L E + +++ L
Sbjct: 417 KQKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL 475
Query: 496 EDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
+ + L EVL++ +N L T + + E + + + L +E + +
Sbjct: 476 QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 535
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES--NSQIK-----FLREEVEKKRVL 608
L E L + EL + E+ + LK+ + NS++K +++VEK+ +
Sbjct: 536 AELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKV 595
Query: 609 CEMXXXXXXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQE 667
E + LL ++ E+ S +E+ LL+
Sbjct: 596 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 655
Query: 668 NEELTMTVAKQSSIIDKLKK 687
EEL ++ + I+++LKK
Sbjct: 656 KEELNNSLKATTQILEELKK 675
Score = 78.6 bits (185), Expect = 7e-14
Identities = 118/527 (22%), Positives = 246/527 (46%), Gaps = 54/527 (10%)
Query: 129 DYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG---TD 185
D K ++ LQ+ LKE ++ ++R+L R N + E +G T
Sbjct: 216 DEKKQLCVLQQ-LKESEHHADLLKGRVE--NLERELEIARTNQEHAALEAENSKGEVETL 272
Query: 186 AEKVSAMINDMRSR---IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEK 241
K+ M +R ++ + + E L NE+ +Q +S LE + + +++ ++ QEK
Sbjct: 273 KAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEK 332
Query: 242 L-----TSNELTLAETQQRLEMVKGHHALALEANESIRRE-YKIELEALKTKLDEEKQAI 295
+ +S + + +TQ + M + + + S + + ++E L+ + + Q +
Sbjct: 333 VQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELEKAQLLQGL 392
Query: 296 ISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE-- 351
+ K + L++ N I+ +++ Q L++K E + +L +Q+ +EQ + +KL Q+E
Sbjct: 393 -DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-LVSKLSQVEGE 450
Query: 352 ----ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
+ + +L+ ++ E++ Q +Q + + T++ L+ K L+ L+LT
Sbjct: 451 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 510
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA---IKEK 464
+++N + + EL E ++ L++EL + E L ++ + +KE
Sbjct: 511 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 570
Query: 465 NKFETSLSVTRDIVHVLTL----RLRESDSE----LEQLEDQVQ-MLTSAKEVLENELTT 515
+ L + D +H + ++RE +E L + E + Q +L + E E+ T
Sbjct: 571 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQT 630
Query: 516 YKNTLNNTVRECDEYKEALVNILK-SKAALT---KEHTRIMEH-NVTLIESLQNV---EK 567
Y+ L + EC ++ +++LK SK L K T+I+E T +++L+ V +K
Sbjct: 631 YREKLTSK-EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKK 689
Query: 568 EAYRELGTIK------NELIEDVELLKKESNSQIKFLREEVEKKRVL 608
E R G +K +L E+ E+L+KE SQ++ +E+ + V+
Sbjct: 690 ENERAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVM 735
Score = 75.4 bits (177), Expect = 7e-13
Identities = 87/335 (25%), Positives = 169/335 (50%), Gaps = 42/335 (12%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ L +++ + +L + Q++E+RN T+ E ++I+ +++ A LQ+ L+ L + +
Sbjct: 437 QEQLVSKLSQVEGEHQLWKEQNLELRNL--TV-ELEQKIQVLQSKNASLQDTLEVLQSSY 493
Query: 149 RQSHNNIDFNEIDR-----KLSKLRINNTNCHTE-HNAVQGTDA--EKVSAMINDMRSRI 200
+ N ++ ++D+ K++K+ T E H Q T E++S N + +
Sbjct: 494 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGEL 553
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL-EMV 259
L ++ ++ +++ + +E S L++ + D + KD EK +AE Q RL E
Sbjct: 554 QLLLEEIKSSKDQLKELTLENSELKKSL---DCMHKDQVEKEGKVREEIAEYQLRLHEAE 610
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
K H AL L+ N ++Y++E++ + KL +++ + S+ K++ + LK+ S E L N
Sbjct: 611 KKHQALLLDTN----KQYEVEIQTYREKLTSKEECLSSQ-KLEIDLLKS----SKEELNN 661
Query: 320 QMLKEKCEALEQLHSQLI--IKE-QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
LK + LE+L + +K ++K + E+ + +K C+ Q EE + +Q+
Sbjct: 662 S-LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK-QLEEEKEILQKEL 719
Query: 377 SQ----QEKT---------IQYLEQEIKELKYTLD 398
SQ QEK + L EIKELK TL+
Sbjct: 720 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 754
>U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase p160ROCK protein.
Length = 1354
Score = 80.2 bits (189), Expect = 2e-14
Identities = 134/587 (22%), Positives = 257/587 (43%), Gaps = 49/587 (8%)
Query: 132 NEIAQLQEILKELATKFR-QSHNNIDF-NEIDRKL--SKLRINNTNCHTEHNAVQGTDAE 187
N LQE L++ K Q HN + +E+++K S ++++ + Q + E
Sbjct: 419 NADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLE 478
Query: 188 KVSAMIND----MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT 243
+ I ++ RI E ++K E + + + + E+S+L++ + + L K Q
Sbjct: 479 STVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQL---EDLKKVSQNSQL 535
Query: 244 SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ 303
+NE L++ Q++LE EAN+ +R E + K+ + K IS+ +
Sbjct: 536 ANE-KLSQLQKQLE----------EANDLLRTESDTAVRLRKSHTEMSKS--ISQLESLN 582
Query: 304 ENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+ + N +E+ K+Q K+ + +A+ + + + EM L+ S E++K
Sbjct: 583 RELQER-NRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVK-- 639
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT-NNQNSDLKQELNNLKNCKDE 420
+ + ++ + + + + E+E L+ L+ + L+QE+N K K
Sbjct: 640 --HLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKAR 697
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
L T+K IEE K++ +EK + E E + K V + K+ + + L ++ +
Sbjct: 698 L-TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLE 756
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
LT + E++ L Q++ ++ + +L+NEL T +N + K+ + +L+
Sbjct: 757 HLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLE 816
Query: 540 SKAALTKEHTRIMEH---NVTLIESLQN-VEKEAYREL--GTIKNELIEDVELLKKESNS 593
+K L E ++ + N + LQ+ +E E Y T EL E++E +E+
Sbjct: 817 AKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK 876
Query: 594 QIKFLREEVEKKRV---LCEMXXXXXXXXXXXXXXSRVLLAQA---AADLSRLE--NENE 645
+I+ L+ E E L E L Q AA +R E +++
Sbjct: 877 KIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDH 936
Query: 646 RYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
L ++ +LR+ENEELT + K KL+K+ E S
Sbjct: 937 TVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEY-KLEKEEEIS 982
Score = 69.7 bits (163), Expect = 3e-11
Identities = 97/518 (18%), Positives = 226/518 (43%), Gaps = 28/518 (5%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q +L +A D+ +R + T K + I+QL+ + +EL + R N+ + D
Sbjct: 544 QKQLEEANDL-LRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKD 602
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAE-KVSAM---INDMRSRIIELEKKCEALDNEVYDK 217
+ + H++ D + +++++ + ++ + ++E + + + +
Sbjct: 603 YYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHS 662
Query: 218 QMELSSLEEVITVR-DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL-EANESIRR 275
+ E ++LE + + SL + L++++ +++T A + + ++ ++A+ E + ++
Sbjct: 663 EKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKE 722
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + +A + EKQ + + Q K +H + +K LEQ ++
Sbjct: 723 EREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNK 782
Query: 336 LIIKEQEMKAKLEQIEE-SASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
++ + E+K + + + EK EI E + ++ +Q K + E +++EL
Sbjct: 783 RLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMREL 842
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ L+ ++ K ++ LK +E + E I+E++ K+ L + E +
Sbjct: 843 QDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESE 902
Query: 454 NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
LA + + E+ FE + ++ + + D + +LE+ MLT E+L E
Sbjct: 903 QLA--RGLLEEQYFELT-QESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRREN 959
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYREL 573
+ E KE ++ L KAA K I + + ++ +A +L
Sbjct: 960 EELTEKMKKAEEEYKLEKEEEISNL--KAAFEKN-----------INTERTLKTQAVNKL 1006
Query: 574 GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
I N +D ++ +K++N+Q ++E E +++ E+
Sbjct: 1007 AEIMNR--KDFKIDRKKANTQ-DLRKKEKENRKLQLEL 1041
Score = 59.3 bits (137), Expect = 5e-08
Identities = 92/457 (20%), Positives = 195/457 (42%), Gaps = 41/457 (8%)
Query: 125 KQIEDYKNEIAQLQEILK-ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEH-NAVQ 182
K+ +D N + + L+ +L K + ++ + K++K R+ + + E +V
Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVA 712
Query: 183 GTDAEKVSAMINDMR----SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+ EK + R +R++++EK+C LD ++ Q +L L + K+L
Sbjct: 713 MCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNL 772
Query: 239 QEKLT--SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK------TKLDE 290
+L SN+ L + + + + + + LE + +++E LEA + +L +
Sbjct: 773 TLQLEQESNKRLLLQNELKTQAFEADNLKGLE--KQMKQEINTLLEAKRLLEFELAQLTK 830
Query: 291 EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQI 350
+ + + + Q+ L+ + S +L +KE E +E+ + + + K QE++ + E +
Sbjct: 831 QYRGNEGQMRELQDQLEAEQYFS--TLYKTQVKELKEEIEEKNRENLKKIQELQNEKETL 888
Query: 351 E---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
+ A K + ++ + E + +K QEI + +T+ NS L
Sbjct: 889 ATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSML 948
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELI-------EKTINYENEKNKLNLAVEKA 460
+++ L+ +EL+ + EE K K+E I EK IN E+ AV K
Sbjct: 949 TKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNIN--TERTLKTQAVNKL 1006
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
+ N+ + R + LR +E ++ QLE L +E + ++ L
Sbjct: 1007 AEIMNR--KDFKIDRKKANTQDLRKKEKENRKLQLE-----LNQEREKFNQMVVKHQKEL 1059
Query: 521 NN----TVRECDEYKEALVNILKSKAALTKEHTRIME 553
N+ V EC E + + ++ + + ++++
Sbjct: 1060 NDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLD 1096
>BX538286-1|CAD98081.1| 724|Homo sapiens hypothetical protein
protein.
Length = 724
Score = 80.2 bits (189), Expect = 2e-14
Identities = 116/503 (23%), Positives = 224/503 (44%), Gaps = 49/503 (9%)
Query: 116 KDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKL-RINNTNC 174
KDQ NKQ Y+ E L ++EL TK Q I+ D K++ R +
Sbjct: 223 KDQNQHTMNKQ---YEKERQGLVTGIEELRTKLIQ----IEAENSDLKVNMAHRTSQFQL 275
Query: 175 HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSL 234
E + +++ K+ + + S+++ LEK+ E + + LE+ + + L
Sbjct: 276 IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQL 335
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQA 294
K Q+ E T++ QQ + + K HH LE+ + + E K E++ K DE +A
Sbjct: 336 EKKDQQ-FKEQEKTMSMLQQDI-ICKQHH---LESLDRLLTESKGEMKKENMKKDEALKA 390
Query: 295 IISKCKVDQENLKTKH-NASIESLKNQML---------KEKCEA-LEQLHSQLIIKEQEM 343
+ ++ V +E +K + ++++E K +++ KEK E L++ ++ ++E+
Sbjct: 391 LQNQ--VSEETIKVRQLDSALEIRKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 448
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHC---SQQEKTIQYLEQEIKELKYTLDLT 400
K K ++E+ SE+ I + +++ Q +Q+ + E T LE+++ +L+ L
Sbjct: 449 KIKNHSLQET-SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ 507
Query: 401 NNQNSD-LKQELNNLKNCKDELSTEKFNFIE------EIKTLKDELIEKTINYENEKNKL 453
+++ L++ ++ E ++ IE ++K D+ E+ E E L
Sbjct: 508 RESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL 567
Query: 454 NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
E ++ + L T+ + T ++E + E ++ +EVLE EL
Sbjct: 568 KRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETEL 627
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYREL 573
L +T+R+ E ++ L KA L+ +E T I+ L +E E+
Sbjct: 628 QNAHGELKSTLRQLQELRDVL-----QKAQLS------LEEKYTTIKDLTAELRECKMEI 676
Query: 574 GTIKNELIEDVELLKKESNSQIK 596
K EL+E + L KE N ++K
Sbjct: 677 EDKKQELLEMDQAL-KERNWELK 698
Score = 66.5 bits (155), Expect = 3e-10
Identities = 138/634 (21%), Positives = 271/634 (42%), Gaps = 81/634 (12%)
Query: 124 NKQIED----YKNEIAQLQEILKELATKFRQSHNN---------IDFNEIDRKLSKLRIN 170
NK++++ YK+E+ EILKE + ++ +NN + +E+ +L++ R +
Sbjct: 4 NKRLQERCGLYKSEL----EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQS 59
Query: 171 NTNCHTEHNAVQGTDAEKVSAMIN--DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI 228
+E +K S M +++ R+ ++ + E+ ++EL SLE++I
Sbjct: 60 ILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKII 119
Query: 229 TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL-EANESIRREYKIEL---EAL 284
+ L+ +L + L++ Q K + EAN+ + E +I+L EA
Sbjct: 120 SQLP-----LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 174
Query: 285 KTKL------DEEKQAIISKCKVDQENLKTKH----------NASIESLKNQMLKEKCEA 328
KL ++ Q++I+ C QE+ K + ES+K+Q +
Sbjct: 175 IQKLHANLTANQLSQSLIT-CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQ 233
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
E+ L+ +E++ KL QIE S+ LK+ + Q IQE ++ LE
Sbjct: 234 YEKERQGLVTGIEELRTKLIQIEAENSD-LKVNMAHRTSQFQLIQEELLEKASNSSKLES 292
Query: 389 EI-KELKYTLDLTNN-------------QNSDLKQELNNLKNCKDELSTEKFNFIEE-IK 433
E+ K+ L L +N++L+QEL + + E ++F E+ +
Sbjct: 293 EMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL--MLEAQLEKKDQQFKEQEKTMS 350
Query: 434 TLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
L+ ++I K + E+ L + + KE K + +L ++ V T+++R+ DS LE
Sbjct: 351 MLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE 410
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ + + LE ++ L E ++ L I T E I++
Sbjct: 411 IRKEELVLHLNQ---LEGNKEKFEKQLKKKSEEVYCLQKEL-KIKNHSLQETSEQNVILQ 466
Query: 554 HNVTLIESLQNVEKEAYR--ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
H TL + Q +++E R EL + +L + V L++E Q + E++ K CE
Sbjct: 467 H--TLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCE- 523
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
R + + +++ E ++Y + E+ L+++ E
Sbjct: 524 ------SAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS---KMEKEIMHLKRDGENK 574
Query: 672 TMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
M +++ I+D+ K +LE+ K L+ S
Sbjct: 575 AMHLSQLDMILDQTKTELEKKTNAVKELEKLQHS 608
Score = 37.1 bits (82), Expect = 0.22
Identities = 37/204 (18%), Positives = 96/204 (47%), Gaps = 17/204 (8%)
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK--DELST 423
E+ ++ +QE C + ++ L++++++LK N N K + +KN + +L+
Sbjct: 1 EKENKRLQERCGLYKSELEILKEKLRQLK-----EENNNGKEKLRIMAVKNSEVMAQLTE 55
Query: 424 EKFNFIEEIKTL--KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
+ + ++ L KDE++ + NE +L + V A E+ L + + +
Sbjct: 56 SRQSILKLESELENKDEILRDKFSLMNENRELKVRV-AAQNER------LDLCQQEIESS 108
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+ LR + + QL + ++ + + +++++ N + + C E + +++ L+ K
Sbjct: 109 RVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI-GCCEANKLVISELRIK 167
Query: 542 AALTKEHTRIMEHNVTLIESLQNV 565
A+ + + + N+T + Q++
Sbjct: 168 LAIKEAEIQKLHANLTANQLSQSL 191
>AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golgin
subfamily a, 4 variant protein.
Length = 1310
Score = 80.2 bits (189), Expect = 2e-14
Identities = 120/653 (18%), Positives = 285/653 (43%), Gaps = 58/653 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ-L 137
K +A ++K L+ + + +L D +I+ ++T E ++ + + Q +
Sbjct: 438 KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 497
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+++K+ + + + E+ RK +L T Q E++ + +
Sbjct: 498 VDVMKKSSEEQIAKLQKLHEKELARKEQEL---TKKLQTREREFQ----EQMKVALEKSQ 550
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
S +++ ++ E ++ + ++EL + ++T ++ +DLQ++ + + E + LE
Sbjct: 551 SEYLKISQEKEQQESLALE-ELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLE 608
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
+L+ N++ ++ + LEA K K ++E ++ K H +ESL
Sbjct: 609 K-------SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK-----------HKTELESL 650
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES-ASEKLKICEIQFEERSQSIQEHC 376
K+Q E L+ L Q + ++++ K EQ +E+ +K I + EE ++ E
Sbjct: 651 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 710
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKT- 434
++ ++ L E+ E+ + S LK + + +K + ++ +K + +++ +
Sbjct: 711 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 770
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+K+ + + K+++N +E +KE++K L + V L ++ S+ EL+Q
Sbjct: 771 IKEHEVSIQRTEKALKDQIN-QLELLLKERDK---HLKEHQAHVENLEADIKRSEGELQQ 826
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEH----TR 550
++ + S + + Y+ L ++ + + + + K A + + T
Sbjct: 827 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 886
Query: 551 IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK-KRVLC 609
+ H + + + +Q +EK+ +E+ + V+ L + S+++ +E E+ K++L
Sbjct: 887 LDAHKIQVQDLMQQLEKQ--------NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 938
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E +L + +A + NE Y ++ ++Q+ +
Sbjct: 939 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK---KMEKVKQKAK 995
Query: 670 ELTMTVAKQSSIID---KLKKDLEQS--QYTPKSPSVLRKSLKVGKENMQTIS 717
E+ T+ K+ ++D KLKK+LE + + + K K L++ + N IS
Sbjct: 996 EMQETLKKK--LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1046
Score = 59.3 bits (137), Expect = 5e-08
Identities = 85/401 (21%), Positives = 182/401 (45%), Gaps = 35/401 (8%)
Query: 124 NKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG 183
++Q + Y+ ++AQLQ+ L +L T+ + ++++++ + TE +A +
Sbjct: 842 HEQTKAYEEQLAQLQQKLLDLETERIL---------LTKQVAEVEAQKKDVCTELDAHK- 891
Query: 184 TDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE-----VITVRDSLCKDL 238
+V ++ + + E+E+K ++L +VY+ ++E + E+ ++ ++++ +
Sbjct: 892 ---IQVQDLMQQLEKQNSEMEQKVKSL-TQVYESKLEDGNKEQEQTKQILVEKENMILQM 947
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E E+ + TQ+ H L E + + K ++E +K K +E Q + K
Sbjct: 948 REG-QKKEIEIL-TQKLSAKEDSIHILNEEYETKFKNQEK-KMEKVKQKA-KEMQETLKK 1003
Query: 299 CKVDQE-NLKTK-HNASIE-SLKNQMLKEKCEALEQLHSQLIIK-----EQEMKAKLEQI 350
+DQE LK + N ++E S K + K + Q +S I E K ++E +
Sbjct: 1004 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1063
Query: 351 EESASEKLK-ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
E +L + I ++ +Q +E E +Q EQE+ ELK + L + ++ +
Sbjct: 1064 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNK 1123
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLK---DELIEKTINYENEKNKLNLAVEKAIKEKNK 466
E+ LK + T E++K + L + + KL + + K++KE
Sbjct: 1124 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1183
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ L + + ++ E S+L+ +++ Q L S+ E
Sbjct: 1184 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1224
Score = 58.0 bits (134), Expect = 1e-07
Identities = 109/547 (19%), Positives = 235/547 (42%), Gaps = 53/547 (9%)
Query: 202 ELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+++ + E L +++ +K+ + L + S E +T+ ++ E ++ ++
Sbjct: 150 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 209
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
+L +R E +++ +A K L EE A + + L+T+ + + L+N
Sbjct: 210 SQSQDKSLRRIAELREELQMDQQA-KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 268
Query: 320 -QMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESAS---------EKLKICEIQFEE 367
M + + L QL Q + KE+ ++ E + E + +++K E +
Sbjct: 269 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 328
Query: 368 RSQSIQEH---C----SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++IQ H C S++E + L++ ++EL+ DL + + L +L + KN ++
Sbjct: 329 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 388
Query: 421 LSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
L +K I E K E + E+ + ++ E+ ++K K E + +
Sbjct: 389 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 448
Query: 477 IVHVLTLRLRESDSELE-QLEDQVQML--TSAKE--VLENELTTYKNTLNNTVRECDEYK 531
+ E+ +L+ ++++Q++ + TS +E L+ EL+ K + + +++ E +
Sbjct: 449 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 508
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
A + L K KE L + LQ E+E ++ + + + +E
Sbjct: 509 IAKLQKLHEKELARKEQ--------ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 560
Query: 592 NSQIKFLREEVE--KKRVLCEM-XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYX 648
Q EE+E KK +L E +R+L +++ + S EN+N+
Sbjct: 561 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ--- 617
Query: 649 XXXXXXXSLVVELSLLR-QENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
L V L + + N+E+T+ V K + ++ LK + + +T K VL++ +
Sbjct: 618 -----SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ-QDALWTEKL-QVLKQQYQ 670
Query: 708 VGKENMQ 714
E ++
Sbjct: 671 TEMEKLR 677
Score = 44.4 bits (100), Expect = 0.001
Identities = 86/372 (23%), Positives = 156/372 (41%), Gaps = 31/372 (8%)
Query: 97 NKILPQD--ELVQAQDVEIRNKDQTICE-YNKQIEDYKNEIAQLQEILKELATKFRQSHN 153
+KI QD + ++ Q+ E+ K +++ + Y ++ED E Q ++IL E Q
Sbjct: 890 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE 949
Query: 154 NIDFNEIDRKLSKLRINNTNCH--TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
EI+ KL + H E + + EK + + E KK + LD
Sbjct: 950 G-QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK-KLLD 1007
Query: 212 NEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
E K++E ++LE + K L E +N +++ RLE + +L
Sbjct: 1008 QEAKLKKELENTALELSQKEKQFNAKML-EMAQANSAGISDAVSRLETNQKEQIESL--T 1064
Query: 271 ESIRREYKIELEALKTKLD---EEKQAI--ISKCKVDQENLKTKHNASIESL-KNQMLKE 324
E RRE + + KL+ EE Q I I + +QE + K + K +M KE
Sbjct: 1065 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1124
Query: 325 ----KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI---CEIQFEERSQSIQEHCS 377
K E ++Q + L ++++K K + A ++ K+ E + ++S++E+
Sbjct: 1125 ITWLKEEGVKQ-DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1183
Query: 378 QQEKTIQYL------EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
QE+ ++ ++++ EL L T+ + LK ++ S E EE
Sbjct: 1184 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1243
Query: 432 IKTLKDELIEKT 443
+ D +KT
Sbjct: 1244 LAIQLDICCKKT 1255
>AB208965-1|BAD92202.1| 705|Homo sapiens Rho-associated,
coiled-coil containing protein kinase 1 variant protein.
Length = 705
Score = 80.2 bits (189), Expect = 2e-14
Identities = 134/587 (22%), Positives = 257/587 (43%), Gaps = 49/587 (8%)
Query: 132 NEIAQLQEILKELATKFR-QSHNNIDF-NEIDRKL--SKLRINNTNCHTEHNAVQGTDAE 187
N LQE L++ K Q HN + +E+++K S ++++ + Q + E
Sbjct: 97 NADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLE 156
Query: 188 KVSAMIND----MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT 243
+ I ++ RI E ++K E + + + + E+S+L++ + + L K Q
Sbjct: 157 STVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQL---EDLKKVSQNSQL 213
Query: 244 SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ 303
+NE L++ Q++LE EAN+ +R E + K+ + K IS+ +
Sbjct: 214 ANE-KLSQLQKQLE----------EANDLLRTESDTAVRLRKSHTEMSKS--ISQLESLN 260
Query: 304 ENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+ + N +E+ K+Q K+ + +A+ + + + EM L+ S E++K
Sbjct: 261 RELQER-NRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVK-- 317
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT-NNQNSDLKQELNNLKNCKDE 420
+ + ++ + + + + E+E L+ L+ + L+QE+N K K
Sbjct: 318 --HLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKAR 375
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
L T+K IEE K++ +EK + E E + K V + K+ + + L ++ +
Sbjct: 376 L-TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLE 434
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
LT + E++ L Q++ ++ + +L+NEL T +N + K+ + +L+
Sbjct: 435 HLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLE 494
Query: 540 SKAALTKEHTRIMEH---NVTLIESLQN-VEKEAYREL--GTIKNELIEDVELLKKESNS 593
+K L E ++ + N + LQ+ +E E Y T EL E++E +E+
Sbjct: 495 AKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK 554
Query: 594 QIKFLREEVEKKRV---LCEMXXXXXXXXXXXXXXSRVLLAQA---AADLSRLE--NENE 645
+I+ L+ E E L E L Q AA +R E +++
Sbjct: 555 KIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDH 614
Query: 646 RYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
L ++ +LR+ENEELT + K KL+K+ E S
Sbjct: 615 TVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEY-KLEKEEEIS 660
Score = 67.3 bits (157), Expect = 2e-10
Identities = 99/504 (19%), Positives = 213/504 (42%), Gaps = 33/504 (6%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q +L +A D+ +R + T K + I+QL+ + +EL + R N+ + D
Sbjct: 222 QKQLEEANDL-LRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKD 280
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ--- 218
+ + H++ D + A I ++ + L+ E ++ E + Q
Sbjct: 281 YYQLQAILEAERRDRGHDSEMIGDLQ---ARITSLQEEVKHLKHNLEKVEGERKEAQDML 337
Query: 219 ----MELSSLEEVITVR-DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL-EANES 272
E ++LE + + SL + L++++ +++T A + + ++ ++A+ E +
Sbjct: 338 NHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKK 397
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL 332
++ E + +A + EKQ + + Q K +H + +K LEQ
Sbjct: 398 LKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQE 457
Query: 333 HSQLIIKEQEMKAKLEQIEE-SASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEI 390
++ ++ + E+K + + + EK EI E + ++ +Q K + E ++
Sbjct: 458 SNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQM 517
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+EL+ L+ ++ K ++ LK +E + E I+E++ K+ L + E +
Sbjct: 518 RELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKA 577
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
LA + + E+ FE + ++ + + D + +LE+ MLT E+L
Sbjct: 578 ESEQLA--RGLLEEQYFELTQE-SKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILR 634
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
E + E KE ++ L KAA K I + + ++ +A
Sbjct: 635 RENEELTEKMKKAEEEYKLEKEEEISNL--KAAFEKN-----------INTERTLKTQAV 681
Query: 571 RELGTIKNELIEDVELLKKESNSQ 594
+L I N +D ++ +K++N+Q
Sbjct: 682 NKLAEIMNR--KDFKIDRKKANTQ 703
Score = 52.0 bits (119), Expect = 7e-06
Identities = 78/379 (20%), Positives = 166/379 (43%), Gaps = 30/379 (7%)
Query: 125 KQIEDYKNEIAQLQEILK-ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEH-NAVQ 182
K+ +D N + + L+ +L K + ++ + K++K R+ + + E +V
Sbjct: 331 KEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVA 390
Query: 183 GTDAEKVSAMINDMR----SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+ EK + R +R++++EK+C LD ++ Q +L L + K+L
Sbjct: 391 MCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNL 450
Query: 239 QEKLT--SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK------TKLDE 290
+L SN+ L + + + + + + LE + +++E LEA + +L +
Sbjct: 451 TLQLEQESNKRLLLQNELKTQAFEADNLKGLE--KQMKQEINTLLEAKRLLEFELAQLTK 508
Query: 291 EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQI 350
+ + + + Q+ L+ + S +L +KE E +E+ + + + K QE++ + E +
Sbjct: 509 QYRGNEGQMRELQDQLEAEQYFS--TLYKTQVKELKEEIEEKNRENLKKIQELQNEKETL 566
Query: 351 E---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
+ A K + ++ + E + +K QEI + +T+ NS L
Sbjct: 567 ATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSML 626
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELI-------EKTINYEN--EKNKLNLAVE 458
+++ L+ +EL+ + EE K K+E I EK IN E + +N E
Sbjct: 627 TKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAE 686
Query: 459 KAIKEKNKFETSLSVTRDI 477
++ K + + T+D+
Sbjct: 687 IMNRKDFKIDRKKANTQDL 705
>X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for
embryonic myosin heavy chain. ).
Length = 1940
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/532 (21%), Positives = 238/532 (44%), Gaps = 52/532 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ KI ++ + EI + T + KQ DY E+ +L E L+E + I
Sbjct: 1106 QKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV---TSTQI 1162
Query: 156 DFNEI-DRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
+ N+ + + KLR + +H A+ T +K + + ++ +I L++ + L+ E
Sbjct: 1163 ELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1222
Query: 215 YDKQMEL----SSLEEVITVR---DSLCKDLQEKLTS----NE-----LTLAETQQ-RLE 257
+ ++E+ SS+E V + + +C+ L+++L+ NE L+ TQ+ RL+
Sbjct: 1223 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 1282
Query: 258 MVKGHHALALEANESI-------RREYKIELEALKTKLDEEKQA------IISKCKVDQE 304
G + LE ESI ++ + + E LK +L+EE +A + + D +
Sbjct: 1283 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
L+ ++ E K ++ + +A ++ E + + E++EE A EKL
Sbjct: 1343 LLREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEE-AQEKLAQRLQD 1400
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
EE+ +++ C+ EKT Q L+ E+++L ++ N+ + L ++ N E T+
Sbjct: 1401 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 1460
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
EE + + ++++ + E KL A E+A+ + + + LT +
Sbjct: 1461 ----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 1516
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
+ E+ + +LE + + K ++ L + L E++EA IL+ + L
Sbjct: 1517 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL--------EHEEA--KILRIQLEL 1566
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
T+ + I E ++ +++ R + T+++ L D E+ + ++K
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL--DAEVRSRNEAIRLK 1616
Score = 75.8 bits (178), Expect = 5e-13
Identities = 104/522 (19%), Positives = 225/522 (43%), Gaps = 49/522 (9%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + IL + Q D ++ KD C+ ++ED + Q Q+ +KEL + +
Sbjct: 1060 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 1119
Query: 152 HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
I+ R ++ + ++ E + + +A V+ S IEL KK EA
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT-------STQIELNKKREA-- 1170
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E + + LEE +++ L++K + L E L+ VK + E
Sbjct: 1171 -EFLKLRRD---LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK-------QKLE 1219
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENL-KTKHNASIESL-KNQMLKEKCEAL 329
+ E+K+E++ L + ++ +SK K + E + +T + E+ KN+ ++ L
Sbjct: 1220 KEKSEFKLEIDDLSSSMES-----VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 1274
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
S+L + E+ +LE+ +ES +L + F ++++ ++ ++ K L
Sbjct: 1275 TTQKSRLQTEAGELSRQLEE-KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
++ ++ DL Q + ++ L+ + ++E + + +T + I++T E
Sbjct: 1334 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEA 1390
Query: 450 KNKLNLAV---EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
+ KL + E+ ++ N SL T+ RL+ E+E L V+ S
Sbjct: 1391 QEKLAQRLQDSEEQVEAVNAKCASLEKTKQ-------RLQ---GEVEDLMVDVERANSLA 1440
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQ 563
L+ + + L +C+E + L LK +L+ E ++ E + +E+++
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500
Query: 564 NVEKEAYRELGTIKNELIEDVELLK--KESNSQIKFLREEVE 603
K +E+ + ++ E+ + + ++S QI+ + +++
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Score = 70.5 bits (165), Expect = 2e-11
Identities = 128/624 (20%), Positives = 267/624 (42%), Gaps = 65/624 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + ++T + +Q+ED ++ + Q +++ +L R+ ++ + S
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL----AQES 1066
Query: 166 KLRINNTNCHTEHNAVQGTDAE--KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N + ++ D E ++ + + D ++ ++ +KK + L Q +
Sbjct: 1067 ILDLENDKQQLDER-LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL-------QARIEE 1118
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LEE I + +++ + L E +RLE G + +E N+ K E E
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK------KREAEF 1172
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQ 341
LK + D E+ + + V L+ KH S+ L Q+ L+ + LE+ S+ ++
Sbjct: 1173 LKLRRDLEEATLQHEAMV--ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 1230
Query: 342 EMKAKLEQIEESASEKLKIC---EIQFEE---RSQSIQEHCSQ---QEKTIQ----YLEQ 388
++ + +E + +S + KIC E Q E +++ IQ S+ Q+ +Q L +
Sbjct: 1231 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 1290
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+++E + + + Q+ LK +E + K +++ + + YE
Sbjct: 1291 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 1350
Query: 449 E---KNKLNLAVEKAIKE----KNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLED 497
E K +L A+ KA E + K+ET ++ T ++ L RL++S+ ++E +
Sbjct: 1351 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNA 1410
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+ L K+ L+ E+ L V + AL ++ + E E +
Sbjct: 1411 KCASLEKTKQRLQGEV----EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466
Query: 558 LIESLQNVEKEAYRELGTIKN---ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+E+ + EL +KN E ++ +E +K+E+ K L +E+ L E
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN----KNLEQEIAD---LTEQ-IA 1518
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
SR + AD+ +L E L ++L L Q E+
Sbjct: 1519 ENGKTIHELEKSRKQIELEKADI-QLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRK 1576
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKS 698
+A++ I++LK++ +++ T +S
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQS 1600
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 186/422 (44%), Gaps = 58/422 (13%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+D+ + ++EK+ A +N+V + ELS L+E I KLT + L E
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA-----------KLTREKKALQEA 1003
Query: 253 -QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHN 311
QQ L+ ++ N++ + + + ++E L++ L++EK K +VD E K K
Sbjct: 1004 HQQALDDLQAEEDKVNSLNKT-KSKLEQQVEDLESSLEQEK-----KLRVDLERNKRKLE 1057
Query: 312 ASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
++ + +L + + +QL +L K+ E ++E+ + +QF+++ +
Sbjct: 1058 GDLKLAQESILDLENDK-QQLDERLKKKDFEYCQLQSKVEDE-----QTLGLQFQKKIKE 1111
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
+Q I+ LE+EI+ + T T Q SD +EL +ELS +EE
Sbjct: 1112 LQAR-------IEELEEEIEAERATRAKTEKQRSDYAREL-------EELSER----LEE 1153
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
+ IE E E KL +E+A + V TLR + +DS
Sbjct: 1154 AGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM------------VATLRKKHADS- 1200
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
+ +L +Q+ L K+ LE E + +K +++ + ++ N+ K L + +
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 1260
Query: 552 MEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
N + SL + + R E G + +L E ++ + S S+ F ++ E KR L
Sbjct: 1261 RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL 1320
Query: 609 CE 610
E
Sbjct: 1321 EE 1322
Score = 62.5 bits (145), Expect = 5e-09
Identities = 78/379 (20%), Positives = 164/379 (43%), Gaps = 31/379 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
++ +E V+A + + + ++T ++ED ++ + + L K R
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN------- 1449
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
D+ L++ + T C ++ + ++ +S + +++ E + E + E
Sbjct: 1450 --FDKVLAEWK---TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+ + E++ L E I +L++ EL A+ Q LE + ALE E+
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA----ALEHEEAKIL 1560
Query: 276 EYKIELEALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCE 327
++EL +K+++D EK I + K + E +++ +A + S + LK+K E
Sbjct: 1561 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 1620
Query: 328 A-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTI 383
L ++ QL ++ L+ + S +LK ++ ++ + ++E + E+
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 1679
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
L+ E++EL+ TL+ T +QEL + L T+ + I K L+ +L++
Sbjct: 1680 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 1739
Query: 444 INYENEKNKLNLAVEKAIK 462
E+ A EKA K
Sbjct: 1740 SEVEDASRDARNAEEKAKK 1758
Score = 60.9 bits (141), Expect = 2e-08
Identities = 51/243 (20%), Positives = 118/243 (48%), Gaps = 11/243 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + + K + +K + ++ L+ K ++ + L+ + E+ E
Sbjct: 845 ETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A ++ +I + + + +++ CS+ +K I LE +
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +EL+ L +L+ EK E + D+L + E++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE----EDKV 1018
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N LN K ++ E+SL + + L R+ + +L+ ++ + L + K+ L+
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 511 NEL 513
L
Sbjct: 1079 ERL 1081
Score = 49.2 bits (112), Expect = 5e-05
Identities = 99/466 (21%), Positives = 198/466 (42%), Gaps = 47/466 (10%)
Query: 78 FKITKAPNSSIKKTLTCPK-NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ 136
FK+ A ++ + T + NK L Q E+ + +I +TI E K + + E A
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQ-EIADLTE-QIAENGKTIHELEKSRKQIELEKAD 1540
Query: 137 LQEILKELATKFRQSHNNI---------DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
+Q L+E I +EIDRK+++ + Q T
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE---KDEEIEQLKRNYQRTVET 1597
Query: 188 KVSAMINDMRSR--IIELEKKCEALDNEV-----YDKQMELSSLEEVITVRDSLCKDLQE 240
SA+ ++RSR I L+KK E NE+ + + +L+ + +V+ L KD Q
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-KDTQL 1656
Query: 241 KLTS---------NELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL----EALKT 286
L +L + E + L + A LE E R+ + EL E ++
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL---EQLHSQLIIKEQEM 343
+ I +K K++ + ++ + S + +EK + + ++ + KEQ+
Sbjct: 1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A LE+++++ + +K + + +E Q + +Q IQ LE I+EL++ L+ +
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ---IQKLETRIRELEFELEGEQKK 1833
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
N++ + L + EL+ + + + L+D + + + ++ K + A E+A
Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
KF + + R ++S++ +L + + TS++ V+
Sbjct: 1894 LTKFRKAQHELEEAEE----RADIAESQVNKLRAKTRDFTSSRMVV 1935
>X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 AA)
protein.
Length = 1167
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/532 (21%), Positives = 238/532 (44%), Gaps = 52/532 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ KI ++ + EI + T + KQ DY E+ +L E L+E + I
Sbjct: 333 QKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV---TSTQI 389
Query: 156 DFNEI-DRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
+ N+ + + KLR + +H A+ T +K + + ++ +I L++ + L+ E
Sbjct: 390 ELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 449
Query: 215 YDKQMEL----SSLEEVITVR---DSLCKDLQEKLTS----NE-----LTLAETQQ-RLE 257
+ ++E+ SS+E V + + +C+ L+++L+ NE L+ TQ+ RL+
Sbjct: 450 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 509
Query: 258 MVKGHHALALEANESI-------RREYKIELEALKTKLDEEKQA------IISKCKVDQE 304
G + LE ESI ++ + + E LK +L+EE +A + + D +
Sbjct: 510 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 569
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
L+ ++ E K ++ + +A ++ E + + E++EE A EKL
Sbjct: 570 LLREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEE-AQEKLAQRLQD 627
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
EE+ +++ C+ EKT Q L+ E+++L ++ N+ + L ++ N E T+
Sbjct: 628 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 687
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
EE + + ++++ + E KL A E+A+ + + + LT +
Sbjct: 688 ----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 743
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
+ E+ + +LE + + K ++ L + L E++EA IL+ + L
Sbjct: 744 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL--------EHEEA--KILRIQLEL 793
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
T+ + I E ++ +++ R + T+++ L D E+ + ++K
Sbjct: 794 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL--DAEVRSRNEAIRLK 843
Score = 75.8 bits (178), Expect = 5e-13
Identities = 104/522 (19%), Positives = 225/522 (43%), Gaps = 49/522 (9%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + IL + Q D ++ KD C+ ++ED + Q Q+ +KEL + +
Sbjct: 287 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 346
Query: 152 HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
I+ R ++ + ++ E + + +A V+ S IEL KK EA
Sbjct: 347 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT-------STQIELNKKREA-- 397
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E + + LEE +++ L++K + L E L+ VK + E
Sbjct: 398 -EFLKLRRD---LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK-------QKLE 446
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENL-KTKHNASIESL-KNQMLKEKCEAL 329
+ E+K+E++ L + ++ +SK K + E + +T + E+ KN+ ++ L
Sbjct: 447 KEKSEFKLEIDDLSSSMES-----VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 501
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
S+L + E+ +LE+ +ES +L + F ++++ ++ ++ K L
Sbjct: 502 TTQKSRLQTEAGELSRQLEE-KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 560
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
++ ++ DL Q + ++ L+ + ++E + + +T + I++T E
Sbjct: 561 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEA 617
Query: 450 KNKLNLAV---EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
+ KL + E+ ++ N SL T+ RL+ E+E L V+ S
Sbjct: 618 QEKLAQRLQDSEEQVEAVNAKCASLEKTKQ-------RLQ---GEVEDLMVDVERANSLA 667
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQ 563
L+ + + L +C+E + L LK +L+ E ++ E + +E+++
Sbjct: 668 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 727
Query: 564 NVEKEAYRELGTIKNELIEDVELLK--KESNSQIKFLREEVE 603
K +E+ + ++ E+ + + ++S QI+ + +++
Sbjct: 728 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 769
Score = 70.5 bits (165), Expect = 2e-11
Identities = 128/624 (20%), Positives = 267/624 (42%), Gaps = 65/624 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + ++T + +Q+ED ++ + Q +++ +L R+ ++ + S
Sbjct: 238 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL----AQES 293
Query: 166 KLRINNTNCHTEHNAVQGTDAE--KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N + ++ D E ++ + + D ++ ++ +KK + L Q +
Sbjct: 294 ILDLENDKQQLDER-LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL-------QARIEE 345
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LEE I + +++ + L E +RLE G + +E N+ K E E
Sbjct: 346 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK------KREAEF 399
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQ 341
LK + D E+ + + V L+ KH S+ L Q+ L+ + LE+ S+ ++
Sbjct: 400 LKLRRDLEEATLQHEAMV--ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 457
Query: 342 EMKAKLEQIEESASEKLKIC---EIQFEE---RSQSIQEHCSQ---QEKTIQ----YLEQ 388
++ + +E + +S + KIC E Q E +++ IQ S+ Q+ +Q L +
Sbjct: 458 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 517
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+++E + + + Q+ LK +E + K +++ + + YE
Sbjct: 518 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 577
Query: 449 E---KNKLNLAVEKAIKE----KNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLED 497
E K +L A+ KA E + K+ET ++ T ++ L RL++S+ ++E +
Sbjct: 578 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNA 637
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+ L K+ L+ E+ L V + AL ++ + E E +
Sbjct: 638 KCASLEKTKQRLQGEV----EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 693
Query: 558 LIESLQNVEKEAYRELGTIKN---ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+E+ + EL +KN E ++ +E +K+E+ K L +E+ L E
Sbjct: 694 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN----KNLEQEIAD---LTEQ-IA 745
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
SR + AD+ +L E L ++L L Q E+
Sbjct: 746 ENGKTIHELEKSRKQIELEKADI-QLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRK 803
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKS 698
+A++ I++LK++ +++ T +S
Sbjct: 804 IAEKDEEIEQLKRNYQRTVETMQS 827
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 186/422 (44%), Gaps = 58/422 (13%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+D+ + ++EK+ A +N+V + ELS L+E I KLT + L E
Sbjct: 182 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA-----------KLTREKKALQEA 230
Query: 253 -QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHN 311
QQ L+ ++ N++ + + + ++E L++ L++EK K +VD E K K
Sbjct: 231 HQQALDDLQAEEDKVNSLNKT-KSKLEQQVEDLESSLEQEK-----KLRVDLERNKRKLE 284
Query: 312 ASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
++ + +L + + +QL +L K+ E ++E+ + +QF+++ +
Sbjct: 285 GDLKLAQESILDLENDK-QQLDERLKKKDFEYCQLQSKVEDE-----QTLGLQFQKKIKE 338
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
+Q I+ LE+EI+ + T T Q SD +EL +ELS +EE
Sbjct: 339 LQAR-------IEELEEEIEAERATRAKTEKQRSDYAREL-------EELSER----LEE 380
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
+ IE E E KL +E+A + V TLR + +DS
Sbjct: 381 AGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM------------VATLRKKHADS- 427
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
+ +L +Q+ L K+ LE E + +K +++ + ++ N+ K L + +
Sbjct: 428 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 487
Query: 552 MEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
N + SL + + R E G + +L E ++ + S S+ F ++ E KR L
Sbjct: 488 RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL 547
Query: 609 CE 610
E
Sbjct: 548 EE 549
Score = 63.3 bits (147), Expect = 3e-09
Identities = 79/379 (20%), Positives = 165/379 (43%), Gaps = 31/379 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
++ +E V+A + + + ++T ++ED ++ + + L K R
Sbjct: 624 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN------- 676
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
D+ L++ + T C ++ + ++ +S + +++ E + E + E
Sbjct: 677 --FDKVLAEWK---TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 731
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+ + E++ L E I +L++ EL A+ Q LE + ALE E+
Sbjct: 732 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA----ALEHEEAKIL 787
Query: 276 EYKIELEALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCE 327
++EL +K+++D EK I + K + E +++ +A + S + LK+K E
Sbjct: 788 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 847
Query: 328 A-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS---IQEHCSQQEKTI 383
L ++ QL ++ L+ + S +LK ++ ++ Q+ ++E + E+
Sbjct: 848 GDLNEIEIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALQTQEDLKEQLAIVERRA 906
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
L+ E++EL+ TL+ T +QEL + L T+ + I K L+ +L++
Sbjct: 907 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 966
Query: 444 INYENEKNKLNLAVEKAIK 462
E+ A EKA K
Sbjct: 967 SEVEDASRDARNAEEKAKK 985
Score = 60.9 bits (141), Expect = 2e-08
Identities = 51/243 (20%), Positives = 118/243 (48%), Gaps = 11/243 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + + K + +K + ++ L+ K ++ + L+ + E+ E
Sbjct: 72 ETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 130
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A ++ +I + + + +++ CS+ +K I LE +
Sbjct: 131 ERCDQLIKAKFQLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 189
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +EL+ L +L+ EK E + D+L + E++
Sbjct: 190 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE----EDKV 245
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N LN K ++ E+SL + + L R+ + +L+ ++ + L + K+ L+
Sbjct: 246 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 305
Query: 511 NEL 513
L
Sbjct: 306 ERL 308
Score = 50.8 bits (116), Expect = 2e-05
Identities = 99/466 (21%), Positives = 200/466 (42%), Gaps = 47/466 (10%)
Query: 78 FKITKAPNSSIKKTLTCPK-NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ 136
FK+ A ++ + T + NK L Q E+ + +I +TI E K + + E A
Sbjct: 710 FKLKNAYEEALDQLETVKRENKNLEQ-EIADLTE-QIAENGKTIHELEKSRKQIELEKAD 767
Query: 137 LQEILKELATKFRQSHNNI---------DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
+Q L+E I +EIDRK+++ + Q T
Sbjct: 768 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE---KDEEIEQLKRNYQRTVET 824
Query: 188 KVSAMINDMRSR--IIELEKKCEALDNEV-----YDKQMELSSLEEVITVRDSLCKDLQE 240
SA+ ++RSR I L+KK E NE+ + + +L+ + +V+ L KD Q
Sbjct: 825 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-KDTQL 883
Query: 241 KLTSNELTLAETQQRLEMVKGHHAL----------ALEANESIRREYKIEL----EALKT 286
L T + +++L +V+ L LE E R+ + EL E ++
Sbjct: 884 HLDDALQTQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 943
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL---EQLHSQLIIKEQEM 343
+ I +K K++ + ++ + S + +EK + + ++ + KEQ+
Sbjct: 944 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1003
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A LE+++++ + +K + + +E Q + +Q IQ LE I+EL++ L+ +
Sbjct: 1004 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ---IQKLETRIRELEFELEGEQKK 1060
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
N++ + L + EL+ + + + L+D + + + ++ K + A E+A
Sbjct: 1061 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1120
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
KF + + R ++S++ +L + + TS++ V+
Sbjct: 1121 LTKFRKAQHELEEAEE----RADIAESQVNKLRAKTRDFTSSRMVV 1162
>BX537964-1|CAD97928.1| 898|Homo sapiens hypothetical protein
protein.
Length = 898
Score = 79.8 bits (188), Expect = 3e-14
Identities = 126/631 (19%), Positives = 258/631 (40%), Gaps = 52/631 (8%)
Query: 115 NKDQTIC---EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
N D+T+C E+N +IE +N I A S N+ I+
Sbjct: 48 NTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISK 107
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
TN TE +KV+ ++ ++RS + YD + ++ +V
Sbjct: 108 TN-ETE---------QKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSV- 156
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLE--MVKGHHALALEANESIRREYKIELEALKTKLD 289
S +DL E++ S L+ + R+ M KG HAL L + ++ +Y + +K +
Sbjct: 157 -SASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVL-FEKCVQDKYLQQEHIIKKLIK 214
Query: 290 EEK---QAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHS-------QLI 337
E K + + C +++NL+ + E+ K M +K+ +E+L+ QLI
Sbjct: 215 ENKKHQELFVDICS-EKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLI 273
Query: 338 IKEQEMKAKLEQIEESASEKL----KICEIQFEERSQSIQEHCSQQEKTI------QYLE 387
++ K ++Q+ + ++++ K CE +E+ + ++ +++++ + LE
Sbjct: 274 AQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLE 333
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+++++ L+ N+ L QE L + E I EI LK+++ I +
Sbjct: 334 KKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVK 393
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+NKL ++ + K+K ++ LT E+D + +D ++ ++E
Sbjct: 394 WAQNKLKAEMDSHKETKDKL-------KETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 446
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
+ NEL + + + K + + +K ++ R + + + +L+ K
Sbjct: 447 IKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVK 506
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
E ++EL + E++ ++ ++I+ L ++V+ L E
Sbjct: 507 CLEDERLRTEDELSKYKEIINRQ-KAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVE 565
Query: 628 VLLAQAAADLSR-LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLK 686
L DL + +E +R L + + L+ E+ L K S +L+
Sbjct: 566 -SLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQ 624
Query: 687 KDLEQSQYTP-KSPSVLRKSLKVGKENMQTI 716
EQ + T S L K ++ KE +QT+
Sbjct: 625 SQCEQMKQTNINLESRLLKEEELRKEEVQTL 655
Score = 47.6 bits (108), Expect = 2e-04
Identities = 71/388 (18%), Positives = 164/388 (42%), Gaps = 34/388 (8%)
Query: 79 KITKAPNSSIKKTLTCPKN-KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
K+T+A + + C K + E +++ +++ + + T E KQ+++ +++
Sbjct: 419 KLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLR-VTKGELEKQMQEKSDQLEMH 477
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+KEL R +D +L LR C + + K +IN +
Sbjct: 478 HAKIKELEDLKRTFKEGMD------ELRTLR-TKVKCLEDERLRTEDELSKYKEIINRQK 530
Query: 198 SRI---IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ 254
+ I ++ K + L ++ + E+ +L+E + +SL DLQ+ + + +E
Sbjct: 531 AEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL 590
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
E + +A + S++ ++ K+ + + S+C ++ +T N
Sbjct: 591 FTERLTSKNAQLQSESNSLQSQFD--------KVSCSESQLQSQC---EQMKQTNINLES 639
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
LK + L++ E ++ L ++L ++ E+KA Q+EE E + Q + + SI++
Sbjct: 640 RLLKEEELRK--EEVQTLQAELACRQTEVKALSTQVEELKDELV----TQRRKHASSIKD 693
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q ++ + L+Q ++ Y ++++ + N ++ ++ S E +
Sbjct: 694 LTKQLQQARRKLDQ-VESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDN 752
Query: 435 L----KDELIEKTINYENEKNKLNLAVE 458
K LIE+ + + + N +E
Sbjct: 753 FPQVDKAMLIERIVRLQKAHARKNEKIE 780
>BC105632-1|AAI05633.1| 898|Homo sapiens chromosome 10 open reading
frame 118 protein.
Length = 898
Score = 79.8 bits (188), Expect = 3e-14
Identities = 126/631 (19%), Positives = 258/631 (40%), Gaps = 52/631 (8%)
Query: 115 NKDQTIC---EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
N D+T+C E+N +IE +N I A S N+ I+
Sbjct: 48 NTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISK 107
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
TN TE +KV+ ++ ++RS + YD + ++ +V
Sbjct: 108 TN-ETE---------QKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSV- 156
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLE--MVKGHHALALEANESIRREYKIELEALKTKLD 289
S +DL E++ S L+ + R+ M KG HAL L + ++ +Y + +K +
Sbjct: 157 -SASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVL-FEKCVQDKYLQQEHIIKKLIK 214
Query: 290 EEK---QAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHS-------QLI 337
E K + + C +++NL+ + E+ K M +K+ +E+L+ QLI
Sbjct: 215 ENKKHQELFVDICS-EKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLI 273
Query: 338 IKEQEMKAKLEQIEESASEKL----KICEIQFEERSQSIQEHCSQQEKTI------QYLE 387
++ K ++Q+ + ++++ K CE +E+ + ++ +++++ + LE
Sbjct: 274 AQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLE 333
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+++++ L+ N+ L QE L + E I EI LK+++ I +
Sbjct: 334 KKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVK 393
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+NKL ++ + K+K ++ LT E+D + +D ++ ++E
Sbjct: 394 WAQNKLKAEMDSHKETKDKL-------KETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 446
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
+ NEL + + + K + + +K ++ R + + + +L+ K
Sbjct: 447 IKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVK 506
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
E ++EL + E++ ++ ++I+ L ++V+ L E
Sbjct: 507 CLEDERLRTEDELSKYKEIINRQ-KAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVE 565
Query: 628 VLLAQAAADLSR-LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLK 686
L DL + +E +R L + + L+ E+ L K S +L+
Sbjct: 566 -SLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQ 624
Query: 687 KDLEQSQYTP-KSPSVLRKSLKVGKENMQTI 716
EQ + T S L K ++ KE +QT+
Sbjct: 625 SQCEQMKQTNINLESRLLKEEELRKEEVQTL 655
Score = 47.6 bits (108), Expect = 2e-04
Identities = 71/388 (18%), Positives = 164/388 (42%), Gaps = 34/388 (8%)
Query: 79 KITKAPNSSIKKTLTCPKN-KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
K+T+A + + C K + E +++ +++ + + T E KQ+++ +++
Sbjct: 419 KLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLR-VTKGELEKQMQEKSDQLEMH 477
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+KEL R +D +L LR C + + K +IN +
Sbjct: 478 HAKIKELEDLKRTFKEGMD------ELRTLR-TKVKCLEDERLRTEDELSKYKEIINRQK 530
Query: 198 SRI---IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ 254
+ I ++ K + L ++ + E+ +L+E + +SL DLQ+ + + +E
Sbjct: 531 AEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL 590
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
E + +A + S++ ++ K+ + + S+C ++ +T N
Sbjct: 591 FTERLTSKNAQLQSESNSLQSQFD--------KVSCSESQLQSQC---EQMKQTNINLES 639
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
LK + L++ E ++ L ++L ++ E+KA Q+EE E + Q + + SI++
Sbjct: 640 RLLKEEELRK--EEVQTLQAELACRQTEVKALSTQVEELKDELV----TQRRKHASSIKD 693
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q ++ + L+Q ++ Y ++++ + N ++ ++ S E +
Sbjct: 694 LTKQLQQARRKLDQ-VESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDN 752
Query: 435 L----KDELIEKTINYENEKNKLNLAVE 458
K LIE+ + + + N +E
Sbjct: 753 FPQVDKAMLIERIVRLQKAHARKNEKIE 780
>BC100670-1|AAI00671.1| 1004|Homo sapiens C10orf118 protein protein.
Length = 1004
Score = 79.8 bits (188), Expect = 3e-14
Identities = 126/631 (19%), Positives = 258/631 (40%), Gaps = 52/631 (8%)
Query: 115 NKDQTIC---EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
N D+T+C E+N +IE +N I A S N+ I+
Sbjct: 154 NTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISK 213
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
TN TE +KV+ ++ ++RS + YD + ++ +V
Sbjct: 214 TN-ETE---------QKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSV- 262
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLE--MVKGHHALALEANESIRREYKIELEALKTKLD 289
S +DL E++ S L+ + R+ M KG HAL L + ++ +Y + +K +
Sbjct: 263 -SASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVL-FEKCVQDKYLQQEHIIKKLIK 320
Query: 290 EEK---QAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHS-------QLI 337
E K + + C +++NL+ + E+ K M +K+ +E+L+ QLI
Sbjct: 321 ENKKHQELFVDICS-EKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLI 379
Query: 338 IKEQEMKAKLEQIEESASEKL----KICEIQFEERSQSIQEHCSQQEKTI------QYLE 387
++ K ++Q+ + ++++ K CE +E+ + ++ +++++ + LE
Sbjct: 380 AQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLE 439
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+++++ L+ N+ L QE L + E I EI LK+++ I +
Sbjct: 440 KKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVK 499
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+NKL ++ + K+K ++ LT E+D + +D ++ ++E
Sbjct: 500 WAQNKLKAEMDSHKETKDKL-------KETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 552
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
+ NEL + + + K + + +K ++ R + + + +L+ K
Sbjct: 553 IKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVK 612
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
E ++EL + E++ ++ ++I+ L ++V+ L E
Sbjct: 613 CLEDERLRTEDELSKYKEIINRQ-KAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVE 671
Query: 628 VLLAQAAADLSR-LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLK 686
L DL + +E +R L + + L+ E+ L K S +L+
Sbjct: 672 -SLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQ 730
Query: 687 KDLEQSQYTP-KSPSVLRKSLKVGKENMQTI 716
EQ + T S L K ++ KE +QT+
Sbjct: 731 SQCEQMKQTNINLESRLLKEEELRKEEVQTL 761
Score = 47.6 bits (108), Expect = 2e-04
Identities = 71/388 (18%), Positives = 164/388 (42%), Gaps = 34/388 (8%)
Query: 79 KITKAPNSSIKKTLTCPKN-KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
K+T+A + + C K + E +++ +++ + + T E KQ+++ +++
Sbjct: 525 KLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLR-VTKGELEKQMQEKSDQLEMH 583
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+KEL R +D +L LR C + + K +IN +
Sbjct: 584 HAKIKELEDLKRTFKEGMD------ELRTLR-TKVKCLEDERLRTEDELSKYKEIINRQK 636
Query: 198 SRI---IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ 254
+ I ++ K + L ++ + E+ +L+E + +SL DLQ+ + + +E
Sbjct: 637 AEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL 696
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
E + +A + S++ ++ K+ + + S+C ++ +T N
Sbjct: 697 FTERLTSKNAQLQSESNSLQSQFD--------KVSCSESQLQSQC---EQMKQTNINLES 745
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
LK + L++ E ++ L ++L ++ E+KA Q+EE E + Q + + SI++
Sbjct: 746 RLLKEEELRK--EEVQTLQAELACRQTEVKALSTQVEELKDELV----TQRRKHASSIKD 799
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q ++ + L+Q ++ Y ++++ + N ++ ++ S E +
Sbjct: 800 LTKQLQQARRKLDQ-VESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDN 858
Query: 435 L----KDELIEKTINYENEKNKLNLAVE 458
K LIE+ + + + N +E
Sbjct: 859 FPQVDKAMLIERIVRLQKAHARKNEKIE 886
>BC060769-1|AAH60769.2| 1107|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1107
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/542 (21%), Positives = 248/542 (45%), Gaps = 40/542 (7%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
++L K K + Q Q+ +R +TI + +++ ++E L + ++L T
Sbjct: 242 ESLQASKEKEADLRKEFQGQEAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 298
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA---EKVSAMINDM---RSRIIEL 203
+ NN+ + ++L + ++H V+ A E++ +D+ S I L
Sbjct: 299 IAENNVQV--LQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 356
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ + + D + E S + E ++ + L+ K S L + QQ LE+ K +
Sbjct: 357 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS--LDEEQKQQILELEKKVN 414
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
EA + + Y+ EL+ L+++L+EE + E L KH+ +IE++ + ++
Sbjct: 415 ----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR 470
Query: 324 EKCEA---LEQLHS--QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQ 373
+K + LE+ H+ +L ++E +++ +LE ++E +KL EI ++ + +
Sbjct: 471 DKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSE 530
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
+ E I L+ + L+ LDLT + LK+ + L N + EL E+ E I
Sbjct: 531 QGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIA 587
Query: 434 TLKDE---LIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES- 488
+K+E ++K + K NL E ++E+ + + + +L L+ RE
Sbjct: 588 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 647
Query: 489 ---DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL 544
DS +++ED + ++ K+ LE +L+ + +L + + ++ L L+ +
Sbjct: 648 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH 707
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ H + E +V ++++ +++ R L ++ + +++ LK ++ R E+E
Sbjct: 708 QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEME 767
Query: 604 KK 605
++
Sbjct: 768 QE 769
Score = 60.5 bits (140), Expect = 2e-08
Identities = 119/610 (19%), Positives = 257/610 (42%), Gaps = 61/610 (10%)
Query: 136 QLQEILKELATKFRQSHNNIDFNEID--RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
++Q+IL E K Q + + E+D RK+ L ++ H + T+ E +
Sbjct: 46 EIQQILAETREKILQYKSKVT-EELDLRRKIQVLE-SSLEDHIKMKQQALTEFEAYKHRV 103
Query: 194 NDMR--------SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
DM+ RI+ + ++ E + + +K L+ KD ++L
Sbjct: 104 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE------KD--KRLALE 155
Query: 246 ELTLAETQQRLEMVKG---HHALALEANESIRREYKIELEALKTKLDE---EKQAIISKC 299
+L A Q+ E++K H A + E +++E+E+L L+E E++ +I
Sbjct: 156 DLQAAHRQEIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDY 215
Query: 300 KVDQENLKTKHNASIESLKNQML--KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ ++ + +++LK L E +A ++ + L + Q +A L + +
Sbjct: 216 EGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTE 275
Query: 358 LKICEIQ---FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
L++ + + ++ Q +Q + E +Q L++++ + K +++ +++ EL
Sbjct: 276 LQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAA 335
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELI--EKTI-NYENEKNKLNLAVEKAIKEKNKFETSL 471
+ + +++ I L+ + E TI + E+EK+++N + + ++E+ F S
Sbjct: 336 RERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-LEEERAFLRSK 394
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEY 530
+ + D E ++ +LE +V + + +E E EL ++ L V + +E
Sbjct: 395 TQSLD---------EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEA 445
Query: 531 KEALVNIL--KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK 588
+ L K A+ H+ + L L+ + L KN+L +++E LK
Sbjct: 446 HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLK 505
Query: 589 KESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----N 644
+ ++ +E+ L +M + L+A RL+NE
Sbjct: 506 EVLEDKLNTANQEIGH---LQDM----VRKSEQGLGSAEGLIASLQDSQERLQNELDLTK 558
Query: 645 ERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSI-IDKLKKDLE--QSQYTPKSPSV 701
+ ++ EL RQ++EE + ++ + +DK+ DLE ++ + S
Sbjct: 559 DSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSK 618
Query: 702 LRKSLKVGKE 711
LR+ L++ E
Sbjct: 619 LREELRLQHE 628
Score = 60.5 bits (140), Expect = 2e-08
Identities = 75/383 (19%), Positives = 165/383 (43%), Gaps = 36/383 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED K+ ++QL ++ R S +++ L+++ + N + + Q T +
Sbjct: 629 EDKKSAMSQLLQLKDREKNAARDSWQK----KVEDLLNQISLLKQNLEIQLSQSQ-TSLQ 683
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A R R L ++ E L+ + + L + K+ +++ N L
Sbjct: 684 QLQAQFTQERQR---LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 740
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
+ + L+ +K H E+ E R E + EL+ L+ +L++E +A+++ + + L
Sbjct: 741 QQKHSAE-LQSLKDAHR---ESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSE---LN 793
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H A+I+ L++ +E A +L + I ++ K + +I ++Q E
Sbjct: 794 HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----------CRITDLQEEL 843
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
R + + H S+ +K +Q+L + I L L+ + ++ E N + L + N
Sbjct: 844 RHR--EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQ----QIRLHEQDLN 897
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
K L+ EL T ++ EKN + K + + +L V+ + + L
Sbjct: 898 -----KRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES 952
Query: 488 SDSELEQLEDQVQMLTSAKEVLE 510
+++ + + MLT ++++
Sbjct: 953 KPEDIQMITELKAMLTERDQIIK 975
>AL365275-1|CAI40383.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/542 (21%), Positives = 248/542 (45%), Gaps = 40/542 (7%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
++L K K + Q Q+ +R +TI + +++ ++E L + ++L T
Sbjct: 275 ESLQASKEKEADLRKEFQGQEAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 331
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA---EKVSAMINDM---RSRIIEL 203
+ NN+ + ++L + ++H V+ A E++ +D+ S I L
Sbjct: 332 IAENNVQV--LQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 389
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ + + D + E S + E ++ + L+ K S L + QQ LE+ K +
Sbjct: 390 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS--LDEEQKQQILELEKKVN 447
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
EA + + Y+ EL+ L+++L+EE + E L KH+ +IE++ + ++
Sbjct: 448 ----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR 503
Query: 324 EKCEA---LEQLHS--QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQ 373
+K + LE+ H+ +L ++E +++ +LE ++E +KL EI ++ + +
Sbjct: 504 DKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
+ E I L+ + L+ LDLT + LK+ + L N + EL E+ E I
Sbjct: 564 QGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIA 620
Query: 434 TLKDE---LIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES- 488
+K+E ++K + K NL E ++E+ + + + +L L+ RE
Sbjct: 621 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 680
Query: 489 ---DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL 544
DS +++ED + ++ K+ LE +L+ + +L + + ++ L L+ +
Sbjct: 681 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH 740
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ H + E +V ++++ +++ R L ++ + +++ LK ++ R E+E
Sbjct: 741 QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEME 800
Query: 604 KK 605
++
Sbjct: 801 QE 802
Score = 60.5 bits (140), Expect = 2e-08
Identities = 75/383 (19%), Positives = 165/383 (43%), Gaps = 36/383 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED K+ ++QL ++ R S +++ L+++ + N + + Q T +
Sbjct: 662 EDKKSAMSQLLQLKDREKNAARDSWQK----KVEDLLNQISLLKQNLEIQLSQSQ-TSLQ 716
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A R R L ++ E L+ + + L + K+ +++ N L
Sbjct: 717 QLQAQFTQERQR---LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 773
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
+ + L+ +K H E+ E R E + EL+ L+ +L++E +A+++ + + L
Sbjct: 774 QQKHSAE-LQSLKDAHR---ESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSE---LN 826
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H A+I+ L++ +E A +L + I ++ K + +I ++Q E
Sbjct: 827 HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----------CRITDLQEEL 876
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
R + + H S+ +K +Q+L + I L L+ + ++ E N + L + N
Sbjct: 877 RHR--EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQ----QIRLHEQDLN 930
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
K L+ EL T ++ EKN + K + + +L V+ + + L
Sbjct: 931 -----KRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES 985
Query: 488 SDSELEQLEDQVQMLTSAKEVLE 510
+++ + + MLT ++++
Sbjct: 986 KPEDIQMITELKAMLTERDQIIK 1008
Score = 59.3 bits (137), Expect = 5e-08
Identities = 116/607 (19%), Positives = 255/607 (42%), Gaps = 55/607 (9%)
Query: 136 QLQEILKELATKFRQSHNNIDFNEID--RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
++Q+IL E K Q + + E+D RK+ L ++ H + T+ E +
Sbjct: 79 EIQQILAETREKILQYKSKVT-EELDLRRKIQVLE-SSLEDHIKMKQQALTEFEAYKHRV 136
Query: 194 NDMR--------SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
DM+ RI+ + ++ E + + +K L+ L L++ ++
Sbjct: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLA--LEDLQAAH 194
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVD 302
E Q+ L+ + H A + E +++E+E+L L+E E++ +I +
Sbjct: 195 R---REIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGK 251
Query: 303 QENLKTKHNASIESLKNQML--KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
++ + +++LK L E +A ++ + L + Q +A L + +L++
Sbjct: 252 LNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM 311
Query: 361 CEIQ---FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
+ + ++ Q +Q + E +Q L++++ + K +++ +++ EL +
Sbjct: 312 VQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARER 371
Query: 418 KDELSTEKFNFIEEIKTLKDELI--EKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+ +++ I L+ + E TI + E+EK+++N + + ++E+ F S + +
Sbjct: 372 LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-LEEERAFLRSKTQS 430
Query: 475 RDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
D E ++ +LE +V + + +E E EL ++ L V + +E
Sbjct: 431 LD---------EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
Query: 534 LVNIL--KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
+ L K A+ H+ + L L+ + L KN+L +++E LK+
Sbjct: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVL 541
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----NERY 647
++ +E+ L +M + L+A RL+NE +
Sbjct: 542 EDKLNTANQEIGH---LQDM----VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL 594
Query: 648 XXXXXXXXSLVVELSLLRQENEELTMTVAKQSSI-IDKLKKDLE--QSQYTPKSPSVLRK 704
++ EL RQ++EE + ++ + +DK+ DLE ++ + S LR+
Sbjct: 595 KETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE 654
Query: 705 SLKVGKE 711
L++ E
Sbjct: 655 ELRLQHE 661
>AL137009-1|CAI20344.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/542 (21%), Positives = 248/542 (45%), Gaps = 40/542 (7%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
++L K K + Q Q+ +R +TI + +++ ++E L + ++L T
Sbjct: 275 ESLQASKEKEADLRKEFQGQEAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 331
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA---EKVSAMINDM---RSRIIEL 203
+ NN+ + ++L + ++H V+ A E++ +D+ S I L
Sbjct: 332 IAENNVQV--LQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 389
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ + + D + E S + E ++ + L+ K S L + QQ LE+ K +
Sbjct: 390 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS--LDEEQKQQILELEKKVN 447
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
EA + + Y+ EL+ L+++L+EE + E L KH+ +IE++ + ++
Sbjct: 448 ----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR 503
Query: 324 EKCEA---LEQLHS--QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQ 373
+K + LE+ H+ +L ++E +++ +LE ++E +KL EI ++ + +
Sbjct: 504 DKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
+ E I L+ + L+ LDLT + LK+ + L N + EL E+ E I
Sbjct: 564 QGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIA 620
Query: 434 TLKDE---LIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES- 488
+K+E ++K + K NL E ++E+ + + + +L L+ RE
Sbjct: 621 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 680
Query: 489 ---DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL 544
DS +++ED + ++ K+ LE +L+ + +L + + ++ L L+ +
Sbjct: 681 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH 740
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ H + E +V ++++ +++ R L ++ + +++ LK ++ R E+E
Sbjct: 741 QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEME 800
Query: 604 KK 605
++
Sbjct: 801 QE 802
Score = 60.5 bits (140), Expect = 2e-08
Identities = 75/383 (19%), Positives = 165/383 (43%), Gaps = 36/383 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED K+ ++QL ++ R S +++ L+++ + N + + Q T +
Sbjct: 662 EDKKSAMSQLLQLKDREKNAARDSWQK----KVEDLLNQISLLKQNLEIQLSQSQ-TSLQ 716
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A R R L ++ E L+ + + L + K+ +++ N L
Sbjct: 717 QLQAQFTQERQR---LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 773
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
+ + L+ +K H E+ E R E + EL+ L+ +L++E +A+++ + + L
Sbjct: 774 QQKHSAE-LQSLKDAHR---ESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSE---LN 826
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H A+I+ L++ +E A +L + I ++ K + +I ++Q E
Sbjct: 827 HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----------CRITDLQEEL 876
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
R + + H S+ +K +Q+L + I L L+ + ++ E N + L + N
Sbjct: 877 RHR--EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQ----QIRLHEQDLN 930
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
K L+ EL T ++ EKN + K + + +L V+ + + L
Sbjct: 931 -----KRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES 985
Query: 488 SDSELEQLEDQVQMLTSAKEVLE 510
+++ + + MLT ++++
Sbjct: 986 KPEDIQMITELKAMLTERDQIIK 1008
Score = 59.3 bits (137), Expect = 5e-08
Identities = 116/607 (19%), Positives = 255/607 (42%), Gaps = 55/607 (9%)
Query: 136 QLQEILKELATKFRQSHNNIDFNEID--RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
++Q+IL E K Q + + E+D RK+ L ++ H + T+ E +
Sbjct: 79 EIQQILAETREKILQYKSKVT-EELDLRRKIQVLE-SSLEDHIKMKQQALTEFEAYKHRV 136
Query: 194 NDMR--------SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
DM+ RI+ + ++ E + + +K L+ L L++ ++
Sbjct: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLA--LEDLQAAH 194
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVD 302
E Q+ L+ + H A + E +++E+E+L L+E E++ +I +
Sbjct: 195 R---REIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGK 251
Query: 303 QENLKTKHNASIESLKNQML--KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
++ + +++LK L E +A ++ + L + Q +A L + +L++
Sbjct: 252 LNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM 311
Query: 361 CEIQ---FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
+ + ++ Q +Q + E +Q L++++ + K +++ +++ EL +
Sbjct: 312 VQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARER 371
Query: 418 KDELSTEKFNFIEEIKTLKDELI--EKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+ +++ I L+ + E TI + E+EK+++N + + ++E+ F S + +
Sbjct: 372 LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-LEEERAFLRSKTQS 430
Query: 475 RDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
D E ++ +LE +V + + +E E EL ++ L V + +E
Sbjct: 431 LD---------EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
Query: 534 LVNIL--KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
+ L K A+ H+ + L L+ + L KN+L +++E LK+
Sbjct: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVL 541
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----NERY 647
++ +E+ L +M + L+A RL+NE +
Sbjct: 542 EDKLNTANQEIGH---LQDM----VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL 594
Query: 648 XXXXXXXXSLVVELSLLRQENEELTMTVAKQSSI-IDKLKKDLE--QSQYTPKSPSVLRK 704
++ EL RQ++EE + ++ + +DK+ DLE ++ + S LR+
Sbjct: 595 KETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE 654
Query: 705 SLKVGKE 711
L++ E
Sbjct: 655 ELRLQHE 661
>AL132874-2|CAI42604.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/542 (21%), Positives = 248/542 (45%), Gaps = 40/542 (7%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
++L K K + Q Q+ +R +TI + +++ ++E L + ++L T
Sbjct: 275 ESLQASKEKEADLRKEFQGQEAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 331
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA---EKVSAMINDM---RSRIIEL 203
+ NN+ + ++L + ++H V+ A E++ +D+ S I L
Sbjct: 332 IAENNVQV--LQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 389
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ + + D + E S + E ++ + L+ K S L + QQ LE+ K +
Sbjct: 390 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS--LDEEQKQQILELEKKVN 447
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
EA + + Y+ EL+ L+++L+EE + E L KH+ +IE++ + ++
Sbjct: 448 ----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR 503
Query: 324 EKCEA---LEQLHS--QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQ 373
+K + LE+ H+ +L ++E +++ +LE ++E +KL EI ++ + +
Sbjct: 504 DKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSE 563
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
+ E I L+ + L+ LDLT + LK+ + L N + EL E+ E I
Sbjct: 564 QGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIA 620
Query: 434 TLKDE---LIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES- 488
+K+E ++K + K NL E ++E+ + + + +L L+ RE
Sbjct: 621 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 680
Query: 489 ---DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL 544
DS +++ED + ++ K+ LE +L+ + +L + + ++ L L+ +
Sbjct: 681 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH 740
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ H + E +V ++++ +++ R L ++ + +++ LK ++ R E+E
Sbjct: 741 QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEME 800
Query: 604 KK 605
++
Sbjct: 801 QE 802
Score = 60.5 bits (140), Expect = 2e-08
Identities = 75/383 (19%), Positives = 165/383 (43%), Gaps = 36/383 (9%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED K+ ++QL ++ R S +++ L+++ + N + + Q T +
Sbjct: 662 EDKKSAMSQLLQLKDREKNAARDSWQK----KVEDLLNQISLLKQNLEIQLSQSQ-TSLQ 716
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A R R L ++ E L+ + + L + K+ +++ N L
Sbjct: 717 QLQAQFTQERQR---LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 773
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
+ + L+ +K H E+ E R E + EL+ L+ +L++E +A+++ + + L
Sbjct: 774 QQKHSAE-LQSLKDAHR---ESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSE---LN 826
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H A+I+ L++ +E A +L + I ++ K + +I ++Q E
Sbjct: 827 HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----------CRITDLQEEL 876
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
R + + H S+ +K +Q+L + I L L+ + ++ E N + L + N
Sbjct: 877 RHR--EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQ----QIRLHEQDLN 930
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
K L+ EL T ++ EKN + K + + +L V+ + + L
Sbjct: 931 -----KRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES 985
Query: 488 SDSELEQLEDQVQMLTSAKEVLE 510
+++ + + MLT ++++
Sbjct: 986 KPEDIQMITELKAMLTERDQIIK 1008
Score = 59.3 bits (137), Expect = 5e-08
Identities = 116/607 (19%), Positives = 255/607 (42%), Gaps = 55/607 (9%)
Query: 136 QLQEILKELATKFRQSHNNIDFNEID--RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
++Q+IL E K Q + + E+D RK+ L ++ H + T+ E +
Sbjct: 79 EIQQILAETREKILQYKSKVT-EELDLRRKIQVLE-SSLEDHIKMKQQALTEFEAYKHRV 136
Query: 194 NDMR--------SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
DM+ RI+ + ++ E + + +K L+ L L++ ++
Sbjct: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLA--LEDLQAAH 194
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVD 302
E Q+ L+ + H A + E +++E+E+L L+E E++ +I +
Sbjct: 195 R---REIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGK 251
Query: 303 QENLKTKHNASIESLKNQML--KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
++ + +++LK L E +A ++ + L + Q +A L + +L++
Sbjct: 252 LNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM 311
Query: 361 CEIQ---FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
+ + ++ Q +Q + E +Q L++++ + K +++ +++ EL +
Sbjct: 312 VQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARER 371
Query: 418 KDELSTEKFNFIEEIKTLKDELI--EKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+ +++ I L+ + E TI + E+EK+++N + + ++E+ F S + +
Sbjct: 372 LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-LEEERAFLRSKTQS 430
Query: 475 RDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
D E ++ +LE +V + + +E E EL ++ L V + +E
Sbjct: 431 LD---------EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 481
Query: 534 LVNIL--KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
+ L K A+ H+ + L L+ + L KN+L +++E LK+
Sbjct: 482 TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVL 541
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----NERY 647
++ +E+ L +M + L+A RL+NE +
Sbjct: 542 EDKLNTANQEIGH---LQDM----VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL 594
Query: 648 XXXXXXXXSLVVELSLLRQENEELTMTVAKQSSI-IDKLKKDLE--QSQYTPKSPSVLRK 704
++ EL RQ++EE + ++ + +DK+ DLE ++ + S LR+
Sbjct: 595 KETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE 654
Query: 705 SLKVGKE 711
L++ E
Sbjct: 655 ELRLQHE 661
>AK091682-1|BAC03719.1| 936|Homo sapiens protein ( Homo sapiens
cDNA FLJ34363 fis, clone FEBRA2015042. ).
Length = 936
Score = 79.8 bits (188), Expect = 3e-14
Identities = 114/542 (21%), Positives = 248/542 (45%), Gaps = 40/542 (7%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
++L K K + Q Q+ +R +TI + +++ ++E L + ++L T
Sbjct: 155 ESLQASKEKEADLRKEFQGQEAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 211
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA---EKVSAMINDM---RSRIIEL 203
+ NN+ + ++L + ++H V+ A E++ +D+ S I L
Sbjct: 212 IAENNVQV--LQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 269
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHH 263
+ + + D + E S + E ++ + L+ K S L + QQ LE+ K +
Sbjct: 270 QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS--LDEEQKQQILELEKKVN 327
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
EA + + Y+ EL+ L+++L+EE + E L KH+ +IE++ + ++
Sbjct: 328 ----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR 383
Query: 324 EKCEA---LEQLHS--QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQ 373
+K + LE+ H+ +L ++E +++ +LE ++E +KL EI ++ + +
Sbjct: 384 DKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSE 443
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
+ E I L+ + L+ LDLT + LK+ + L N + EL E+ E I
Sbjct: 444 QGLGSAEGLIASLQDSQERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIA 500
Query: 434 TLKDE---LIEKTINYENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES- 488
+K+E ++K + K NL E ++E+ + + + +L L+ RE
Sbjct: 501 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 560
Query: 489 ---DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL 544
DS +++ED + ++ K+ LE +L+ + +L + + ++ L L+ +
Sbjct: 561 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEERH 620
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ H + E +V ++++ +++ R L ++ + +++ LK ++ R E+E
Sbjct: 621 QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEME 680
Query: 604 KK 605
++
Sbjct: 681 QE 682
Score = 58.0 bits (134), Expect = 1e-07
Identities = 73/339 (21%), Positives = 158/339 (46%), Gaps = 39/339 (11%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED K+ ++QL ++ R S +++ L+++ + N + + Q T +
Sbjct: 542 EDKKSAMSQLLQLKDREKNAARDSWQK----KVEDLLNQISLLKQNLEIQLSQSQ-TSLQ 596
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A R R+ + ++ E + + K ++ + + T+ + K+ +++ N L
Sbjct: 597 QLQAQFTQERQRLTQELEELEERHQQRH-KSLKEAHVLAFQTMEEE--KEKEQRALENHL 653
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
+ + L+ +K H E+ E R E + EL+ L+ +L++E +A+++ + + L
Sbjct: 654 QQKHSAE-LQSLKDAHR---ESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSE---LN 706
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H A+I+ L++ +E A +L + I ++ K + +I ++Q E
Sbjct: 707 HQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI----------CRITDLQEEL 756
Query: 368 RSQSIQEHCSQQEKTIQYLEQEI----KELKY----TLDLTNNQNSDLKQELNNLKNCKD 419
R + + H S+ +K +Q+L + I KEL++ L + + N ++ E K
Sbjct: 757 RHR--EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMR 814
Query: 420 ELSTEKFNFIEEIK---TLKDELIEKTI-NYENEKNKLN 454
E E I E+K T +D++I+K I +N+K+ N
Sbjct: 815 ESKPEDIQMITELKAMLTERDQIIKKLIQKKKNDKSPTN 853
Score = 56.0 bits (129), Expect = 4e-07
Identities = 93/482 (19%), Positives = 207/482 (42%), Gaps = 38/482 (7%)
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVDQENLK 307
E Q+ L+ + H A + E +++E+E+L L+E E++ +I + +
Sbjct: 77 EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ 136
Query: 308 TKHNASIESLKNQML--KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ- 364
+ + +++LK L E +A ++ + L + Q +A L + +L++ + +
Sbjct: 137 SFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEA 196
Query: 365 --FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++ Q +Q + E +Q L++++ + K +++ +++ EL + + +
Sbjct: 197 GSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQA 256
Query: 423 TEKFNFIEEIKTLKDELI--EKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
++ I L+ + E TI + E+EK+++N + + ++E+ F S + + D
Sbjct: 257 SDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ-LEEERAFLRSKTQSLD--- 312
Query: 480 VLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
E ++ +LE +V + + +E E EL ++ L V + +E + L
Sbjct: 313 ------EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEEL 366
Query: 539 --KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
K A+ H+ + L L+ + L KN+L +++E LK+ ++
Sbjct: 367 AWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLN 426
Query: 597 FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----NERYXXXXX 652
+E+ L +M + L+A RL+NE +
Sbjct: 427 TANQEIGH---LQDM----VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKD 479
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSI-IDKLKKDLE--QSQYTPKSPSVLRKSLKVG 709
++ EL RQ++EE + ++ + +DK+ DLE ++ + S LR+ L++
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQ 539
Query: 710 KE 711
E
Sbjct: 540 HE 541
>BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated,
coiled-coil containing protein kinase 1 protein.
Length = 1354
Score = 79.4 bits (187), Expect = 4e-14
Identities = 134/587 (22%), Positives = 256/587 (43%), Gaps = 49/587 (8%)
Query: 132 NEIAQLQEILKELATKFR-QSHNNIDF-NEIDRKL--SKLRINNTNCHTEHNAVQGTDAE 187
N LQE L++ K Q HN + +E+++K S ++++ + Q + E
Sbjct: 419 NADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLE 478
Query: 188 KVSAMIND----MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT 243
+ I ++ RI E ++K E + + + + E+S+L+ + + L K Q
Sbjct: 479 STVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQL---EDLKKVSQNSQL 535
Query: 244 SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ 303
+NE L++ Q++LE EAN+ +R E + K+ + K IS+ +
Sbjct: 536 ANE-KLSQLQKQLE----------EANDLLRTESDTAVRLRKSHTEMSKS--ISQLESLN 582
Query: 304 ENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+ + N +E+ K+Q K+ + +A+ + + + EM L+ S E++K
Sbjct: 583 RELQER-NRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVK-- 639
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT-NNQNSDLKQELNNLKNCKDE 420
+ + ++ + + + + E+E L+ L+ + L+QE+N K K
Sbjct: 640 --HLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKAR 697
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
L T+K IEE K++ +EK + E E + K V + K+ + + L ++ +
Sbjct: 698 L-TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLE 756
Query: 480 VLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
LT + E++ L Q++ ++ + +L+NEL T +N + K+ + +L+
Sbjct: 757 HLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLE 816
Query: 540 SKAALTKEHTRIMEH---NVTLIESLQN-VEKEAYREL--GTIKNELIEDVELLKKESNS 593
+K L E ++ + N + LQ+ +E E Y T EL E++E +E+
Sbjct: 817 AKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK 876
Query: 594 QIKFLREEVEKKRV---LCEMXXXXXXXXXXXXXXSRVLLAQA---AADLSRLE--NENE 645
+I+ L+ E E L E L Q AA +R E +++
Sbjct: 877 KIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDH 936
Query: 646 RYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
L ++ +LR+ENEELT + K KL+K+ E S
Sbjct: 937 TVSRLEEANSMLTKDIEILRRENEELTERMKKAEEEY-KLEKEEEIS 982
Score = 69.7 bits (163), Expect = 3e-11
Identities = 97/518 (18%), Positives = 226/518 (43%), Gaps = 28/518 (5%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q +L +A D+ +R + T K + I+QL+ + +EL + R N+ + D
Sbjct: 544 QKQLEEANDL-LRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKD 602
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAE-KVSAM---INDMRSRIIELEKKCEALDNEVYDK 217
+ + H++ D + +++++ + ++ + ++E + + + +
Sbjct: 603 YYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHS 662
Query: 218 QMELSSLEEVITVR-DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL-EANESIRR 275
+ E ++LE + + SL + L++++ +++T A + + ++ ++A+ E + ++
Sbjct: 663 EKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKE 722
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + +A + EKQ + + Q K +H + +K LEQ ++
Sbjct: 723 EREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNK 782
Query: 336 LIIKEQEMKAKLEQIEE-SASEKLKICEIQ-FEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
++ + E+K + + + EK EI E + ++ +Q K + E +++EL
Sbjct: 783 RLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMREL 842
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ L+ ++ K ++ LK +E + E I+E++ K+ L + E +
Sbjct: 843 QDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESE 902
Query: 454 NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
LA + + E+ FE + ++ + + D + +LE+ MLT E+L E
Sbjct: 903 QLA--RGLLEEQYFELT-QESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRREN 959
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYREL 573
+ E KE ++ L KAA K I + + ++ +A +L
Sbjct: 960 EELTERMKKAEEEYKLEKEEEISNL--KAAFEKN-----------INTERTLKTQAVNKL 1006
Query: 574 GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
I N +D ++ +K++N+Q ++E E +++ E+
Sbjct: 1007 AEIMNR--KDFKIDRKKANTQ-DLRKKEKENRKLQLEL 1041
Score = 58.8 bits (136), Expect = 6e-08
Identities = 92/457 (20%), Positives = 194/457 (42%), Gaps = 41/457 (8%)
Query: 125 KQIEDYKNEIAQLQEILK-ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEH-NAVQ 182
K+ +D N + + L+ +L K + ++ + K++K R+ + + E +V
Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVA 712
Query: 183 GTDAEKVSAMINDMR----SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+ EK + R +R++++EK+C LD ++ Q +L L + K+L
Sbjct: 713 MCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNL 772
Query: 239 QEKLT--SNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK------TKLDE 290
+L SN+ L + + + + + + LE + +++E LEA + +L +
Sbjct: 773 TLQLEQESNKRLLLQNELKTQAFEADNLKGLE--KQMKQEINTLLEAKRLLEFELAQLTK 830
Query: 291 EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQI 350
+ + + + Q+ L+ + S +L +KE E +E+ + + + K QE++ + E +
Sbjct: 831 QYRGNEGQMRELQDQLEAEQYFS--TLYKTQVKELKEEIEEKNRENLKKIQELQNEKETL 888
Query: 351 E---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
+ A K + ++ + E + +K QEI + +T+ NS L
Sbjct: 889 ATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSML 948
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELI-------EKTINYENEKNKLNLAVEKA 460
+++ L+ +EL+ EE K K+E I EK IN E+ AV K
Sbjct: 949 TKDIEILRRENEELTERMKKAEEEYKLEKEEEISNLKAAFEKNIN--TERTLKTQAVNKL 1006
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
+ N+ + R + LR +E ++ QLE L +E + ++ L
Sbjct: 1007 AEIMNR--KDFKIDRKKANTQDLRKKEKENRKLQLE-----LNQEREKFNQMVVKHQKEL 1059
Query: 521 NN----TVRECDEYKEALVNILKSKAALTKEHTRIME 553
N+ V EC E + + ++ + + ++++
Sbjct: 1060 NDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLD 1096
>AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22037 fis, clone HEP08868. ).
Length = 746
Score = 79.4 bits (187), Expect = 4e-14
Identities = 141/663 (21%), Positives = 277/663 (41%), Gaps = 48/663 (7%)
Query: 91 TLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE---LATK 147
TL+ KN + Q +QA+ + + ++ + K D +++I+ ++E L+E +A
Sbjct: 71 TLSQEKNDLTIQ---LQAEQENLMDAEERLTWMMKTKMDLESQISDMRERLEEEEGMAAS 127
Query: 148 FRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSR---IIELE 204
+ ++ D K + T TE Q D KV + D+ R I +L+
Sbjct: 128 LSAAKRKLEGELSDLKRDLEGLETTLAKTEKEK-QALD-HKVRTLTGDLSLREDSITKLQ 185
Query: 205 KKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA 264
K+ AL+ E++ K ++ EE + L K+ KL++ + E + E K A
Sbjct: 186 KEKRALE-ELHQKTLDDLQAEEDKV--NHLTKN-NSKLSTQ---IHELEDNWEQEKKIRA 238
Query: 265 LALEANESIRREYKIELEAL----KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
+A + K+ ++ L ++KLD E+ +++ N K + S+ S +
Sbjct: 239 EVEKARRKAESDLKMTIDNLNEMERSKLDLEEVVKKRDLEINSVNSKYEDEQSLNSTLQR 298
Query: 321 MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQE 380
LKE + +E+L +L E+ M+AK+EQ + +E LK+ + EE + + S
Sbjct: 299 KLKEHQDRIEELEEEL-EAERAMRAKIEQNRKREAELLKL-RRELEEAALQSEATASTLR 356
Query: 381 K----TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
K ++ L + ++ L+ +K E+++L + + K N ++ L+
Sbjct: 357 KKHVDSMAELTEHVESLQRVKSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLE 416
Query: 437 DELIEKTINY-ENEKNKLNL-AVEKAIKEKN-----KFETSLSVTRDIVHVLTLRLRESD 489
D L E E E+N+ + A+ ++ +N ++E S S I+ + T + D
Sbjct: 417 DSLSEANAKVAELERNQAEINAIRTRLQAENSELSREYEESQSRLNQILRIKTSLTSQVD 476
Query: 490 SELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHT 549
QL+++ + ++A L N K+ L+ + +E + + + + L E T
Sbjct: 477 DYKRQLDEESKSRSTAVVSLANT----KHDLDLVKEQLEEEQGGKSELQRLVSKLNTEVT 532
Query: 550 R-IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK---FLREEVEKK 605
++ I+ + +E E R+L E E E + + S K L+ EVE
Sbjct: 533 TWRTKYETDAIQRTEELE-ETKRKLAARLQEAEEAAETAQARAASLEKNKQRLQAEVEDL 591
Query: 606 RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR 665
+ E +LA+ L+ E + + ++
Sbjct: 592 TIDLEKANAAAAALDKKQRLFDKMLAEWQQKCEELQVEVDSSQKECRMYMTESFKIKTAY 651
Query: 666 QENEELTMTVAKQSSIIDKLKKDL-EQSQYTPKSP---SVLRKSLKVGKENMQTISPLRE 721
+E+ E +V K++ + + KDL +Q +S L+K L++ KE +Q E
Sbjct: 652 EESLEHLESVKKENKTLQEEIKDLIDQLGEGGRSVHELQKLKKKLEMEKEELQVALEEAE 711
Query: 722 RNL 724
+L
Sbjct: 712 SSL 714
Score = 54.8 bits (126), Expect = 1e-06
Identities = 90/456 (19%), Positives = 199/456 (43%), Gaps = 40/456 (8%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L +A ++ ++ + A+ + + + K ELE L +EK + + + +QENL
Sbjct: 32 LNVARQEEEMKAKEEELRKAMAQTQELVNKVK-ELEEKTATLSQEKNDLTIQLQAEQENL 90
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHS--QLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
E M+K K + Q+ + + +E+ M A L +A KL+
Sbjct: 91 -----MDAEERLTWMMKTKMDLESQISDMRERLEEEEGMAASL----SAAKRKLEGELSD 141
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK----DE 420
+ + ++ ++ EK Q L+ +++ L L L + + L++E L+ D+
Sbjct: 142 LKRDLEGLETTLAKTEKEKQALDHKVRTLTGDLSLREDSITKLQKEKRALEELHQKTLDD 201
Query: 421 LSTE--KFNFIEEIKT-LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
L E K N + + + L ++ E N+E EK K+ VEKA + K E+ L +T D
Sbjct: 202 LQAEEDKVNHLTKNNSKLSTQIHELEDNWEQEK-KIRAEVEKA---RRKAESDLKMTIDN 257
Query: 478 VHVLTLRLRESDSELEQLEDQVQM-LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVN 536
++ + S +LE++ + + + S E+E + +TL ++E + E L
Sbjct: 258 LN----EMERSKLDLEEVVKKRDLEINSVNSKYEDE-QSLNSTLQRKLKEHQDRIEELEE 312
Query: 537 ILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE---LGTIKNELIEDVELLKKESNS 593
L+++ A+ + + + L++ + +E+ A + T++ + ++ + L + S
Sbjct: 313 ELEAERAMRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRKKHVDSMAELTEHVES 372
Query: 594 QIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE----NERYXX 649
++ ++ ++EK + + + S++ A A + +LE+ N +
Sbjct: 373 -LQRVKSKLEKDKQVMKAEIDDLNASMETIQKSKM---NAEAHVRKLEDSLSEANAKVAE 428
Query: 650 XXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKL 685
+ + L+ EN EL+ + S ++++
Sbjct: 429 LERNQAEINAIRTRLQAENSELSREYEESQSRLNQI 464
Score = 40.7 bits (91), Expect = 0.018
Identities = 73/383 (19%), Positives = 159/383 (41%), Gaps = 27/383 (7%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K+K+ ++++A+ ++ +TI + E + + +L++ L E K + N
Sbjct: 377 KSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAH---VRKLEDSLSEANAKVAELERNQ 433
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
EI+ ++L+ N+ E+ Q ++ + + S++ + +++ LD E
Sbjct: 434 A--EINAIRTRLQAENSELSREYEESQSR-LNQILRIKTSLTSQVDDYKRQ---LDEESK 487
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTS-NELTLAETQQRLEMVKG---HHALALEANE 271
+ + SL D + + L+E+ +EL ++ E+ + A++ E
Sbjct: 488 SRSTAVVSLANTKHDLDLVKEQLEEEQGGKSELQRLVSKLNTEVTTWRTKYETDAIQRTE 547
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
+ E K +L A + +E + ++ ++N K + A +E L + K A
Sbjct: 548 ELE-ETKRKLAARLQEAEEAAETAQARAASLEKN-KQRLQAEVEDLTIDLEKANAAAAAL 605
Query: 332 LHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERS------QSIQEHCSQQEKTI 383
Q + + E + K E+++ K C + E + EH +K
Sbjct: 606 DKKQRLFDKMLAEWQQKCEELQVEVDSSQKECRMYMTESFKIKTAYEESLEHLESVKKEN 665
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ L++EIK+L L +L++ L+ K+EL +EE ++ + K
Sbjct: 666 KTLQEEIKDLIDQLGEGGRSVHELQKLKKKLEMEKEELQVA----LEEAESSLEVEESKV 721
Query: 444 INYENEKNKLNLAVEKAIKEKNK 466
I + E ++ +++ I EK K
Sbjct: 722 IRIQLELAQVKADIDRRIHEKKK 744
>U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein.
Length = 3113
Score = 79.0 bits (186), Expect = 5e-14
Identities = 121/619 (19%), Positives = 256/619 (41%), Gaps = 31/619 (5%)
Query: 80 ITKAPNSSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
I A NS + +TL ++ ++ + V +R++ + + KQI++ + ++++L
Sbjct: 2173 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL---TKQIQEKQGQLSELD 2229
Query: 139 EILKELATKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
++L + + I E + ++ N E A D E + A +
Sbjct: 2230 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2289
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
I E + ++ E ++E +++ ++ + L + E + +
Sbjct: 2290 PPIEEEHQLRNSI--EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2347
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIES 316
HA ALEA S K E+E LK K++ Q++ ++D +++ K N + E
Sbjct: 2348 RTNQEHA-ALEAENS-----KGEVETLKAKIEGMTQSLRG-LELDVVTIRSEKENLTNEL 2400
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
K Q E+ LE ++S QE + + Q++E +S +++ + Q +E ++ +
Sbjct: 2401 QKEQ---ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALH 2457
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
+ QE + EQ + L+L + + L Q L+ KN L + I+E++ K
Sbjct: 2458 NDQE-ACKAKEQNLSSQVECLEL---EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2513
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+L +K KN++ E+ + + ++ E + ++ L E + +++ L+
Sbjct: 2514 QKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2572
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+ L EVL++ +N L T + + E + + + L +E + +
Sbjct: 2573 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2632
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKES--NSQIK-----FLREEVEKKRVLC 609
L E L + EL + E+ + LK+ + NS++K +++VEK+ +
Sbjct: 2633 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2692
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQEN 668
E + LL ++ E+ S +E+ LL+
Sbjct: 2693 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2752
Query: 669 EELTMTVAKQSSIIDKLKK 687
EEL ++ + I+++LKK
Sbjct: 2753 EELNNSLKATTQILEELKK 2771
Score = 79.0 bits (186), Expect = 5e-14
Identities = 118/526 (22%), Positives = 240/526 (45%), Gaps = 52/526 (9%)
Query: 129 DYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG---TD 185
D K ++ LQ+ LKE ++ ++R+L R N + E +G T
Sbjct: 2312 DEKKQLCVLQQ-LKESEHHADLLKGRVE--NLERELEIARTNQEHAALEAENSKGEVETL 2368
Query: 186 AEKVSAMINDMRSR---IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEK 241
K+ M +R ++ + + E L NE+ +Q +S LE + + +++ ++ QEK
Sbjct: 2369 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2428
Query: 242 LTSNELTLAETQQRLEMVK--GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ E + + +K AL ++ + + L + L+ EK ++
Sbjct: 2429 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2488
Query: 300 KVDQEN---LKTKHNASIESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE--- 351
+ N L++ N I+ +++ Q L++K E + +L +Q+ +EQ + +KL Q+E
Sbjct: 2489 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-LVSKLSQVEGEH 2547
Query: 352 ---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+ + +L+ ++ E++ Q +Q + + T++ L+ K L+ L+LT
Sbjct: 2548 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2607
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA---IKEKN 465
+++N + + EL E ++ L++EL + E L ++ + +KE
Sbjct: 2608 EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2667
Query: 466 KFETSLSVTRDIVHVLTL----RLRESDSE----LEQLEDQVQ-MLTSAKEVLENELTTY 516
+ L + D +H + ++RE +E L + E + Q +L + E E+ TY
Sbjct: 2668 LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY 2727
Query: 517 KNTLNNTVRECDEYKEALVNILK-SKAALT---KEHTRIMEH-NVTLIESLQNV---EKE 568
+ L + EC ++ +++LK SK L K T+I+E T +++L+ V +KE
Sbjct: 2728 REKLTSK-EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2786
Query: 569 AYRELGTIK------NELIEDVELLKKESNSQIKFLREEVEKKRVL 608
R G +K +L E+ E+L+KE SQ++ +E+ + V+
Sbjct: 2787 NERAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVM 2831
Score = 75.4 bits (177), Expect = 7e-13
Identities = 87/335 (25%), Positives = 169/335 (50%), Gaps = 42/335 (12%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ L +++ + +L + Q++E+RN T+ E ++I+ +++ A LQ+ L+ L + +
Sbjct: 2533 QEQLVSKLSQVEGEHQLWKEQNLELRNL--TV-ELEQKIQVLQSKNASLQDTLEVLQSSY 2589
Query: 149 RQSHNNIDFNEIDR-----KLSKLRINNTNCHTE-HNAVQGTDA--EKVSAMINDMRSRI 200
+ N ++ ++D+ K++K+ T E H Q T E++S N + +
Sbjct: 2590 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGEL 2649
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL-EMV 259
L ++ ++ +++ + +E S L++ + D + KD EK +AE Q RL E
Sbjct: 2650 QLLLEEIKSSKDQLKELTLENSELKKSL---DCMHKDQVEKEGKVREEIAEYQLRLHEAE 2706
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
K H AL L+ N ++Y++E++ + KL +++ + S+ K++ + LK+ S E L N
Sbjct: 2707 KKHQALLLDTN----KQYEVEIQTYREKLTSKEECLSSQ-KLEIDLLKS----SKEELNN 2757
Query: 320 QMLKEKCEALEQLHSQLI--IKE-QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
LK + LE+L + +K ++K + E+ + +K C+ Q EE + +Q+
Sbjct: 2758 S-LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK-QLEEEKEILQKEL 2815
Query: 377 SQ----QEKT---------IQYLEQEIKELKYTLD 398
SQ QEK + L EIKELK TL+
Sbjct: 2816 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2850
Score = 74.9 bits (176), Expect = 9e-13
Identities = 115/524 (21%), Positives = 231/524 (44%), Gaps = 59/524 (11%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE-----LATKFRQ 150
+NKI + +Q + E++ + E Q+E K E+ + +++L + + T +
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 151 SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
+ + +++KL KL TE + Q +AE S LE+K +
Sbjct: 351 DQASTKYTALEQKLKKL--------TEDLSCQRQNAE----------SARCSLEQKIKEK 392
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
+ E Q ELS + D C ++ +LT E QQ M H+ L E +
Sbjct: 393 EKEF---QEELSRQQRSFQTLDQECIQMKARLTQ------ELQQAKNM---HNVLQAELD 440
Query: 271 E--SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKC 326
+ S++++ + LE K KL +QA ++ + L+ S+E +K N +LK
Sbjct: 441 KLTSVKQQLENNLEEFKQKLCRAEQA-FQASQIKENELR----RSMEEMKKENNLLKSHS 495
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK--TIQ 384
E + L + + +K L Q ++ +E++K E + +QE +QQE T++
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQ-SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-TEKFNFIEEIKTLKDELIEKT 443
L+ + +L+ D + + LK+ ++++ D+LS TEK E K L L K
Sbjct: 555 KLKLAVADLEKQRDCSQDL---LKKREHHIEQLNDKLSKTEK-----ESKALLSALELKK 606
Query: 444 INYENEKNKLNLAVEKAIKEK--NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
YE ++ K + K+ EK + E+ + ++ L L+ + + ++V+
Sbjct: 607 KEYELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 666
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIES 561
L +E L E+ N L++ E + K A + + + ++H + +E+
Sbjct: 667 LEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQ 726
Query: 562 LQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
L ++ +L + NE++ D + ++ +++ + LR+ ++ K
Sbjct: 727 LTGQVEDLEHKLQLLSNEIM-DKDRCYQDLHAEYESLRDLLKSK 769
Score = 74.9 bits (176), Expect = 9e-13
Identities = 132/549 (24%), Positives = 230/549 (41%), Gaps = 55/549 (10%)
Query: 89 KKTL-TCPKN---KILPQDELVQAQDVEIRNKDQTICEYNKQIE--DYKNEIAQLQEILK 142
+KTL +C K+ K+L Q E + ++++ + C +QI+ +Y + L+ +
Sbjct: 614 EKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 672
Query: 143 ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRII 201
L+ + R HN +D ++ + KL E + + + E + + + ++
Sbjct: 673 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 732
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE K + L NE+ DK L E ++RD L K L +NE +
Sbjct: 733 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD-LLKSKDASLVTNEDHQRSLLAFDQQPA 791
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLK- 318
HH+ A E + E + + D+ K + I + +VD S+ES K
Sbjct: 792 MHHSFANIIGE--QGSMPSERSECRLEADQSPKNSAILQNRVDSLEF------SLESQKQ 843
Query: 319 -NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQS--IQ 373
N L+++CE L Q+ + I+E MKA EQ+ +S A +I ++Q + + +
Sbjct: 844 MNSDLQKQCEELVQIKGE--IEENLMKA--EQMHQSFVAETSQRISKLQEDTSAHQNVVA 899
Query: 374 EHCS---QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
E S +EK +Q L +++ + + N L+ L L+ + LS EK
Sbjct: 900 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 959
Query: 431 EIKTLKDELIE--------KTINYENEKNKLNLAVEKA------IKEKNKFETSLS-VTR 475
I K E+ E K IN + K+NL ++K+ I E+ K + LS +
Sbjct: 960 IISLNKREIEELTQENGTLKEINASLNQEKMNL-IQKSESFANYIDEREKSISELSDQYK 1018
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+L R E+ + E L + + LE L + N E ++ KEA
Sbjct: 1019 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1078
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ + LTK E N L+ L+ V++ E+ +N + LK+E I
Sbjct: 1079 K--EHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE----I 1131
Query: 596 KFLREEVEK 604
L+EE K
Sbjct: 1132 MTLKEEQNK 1140
Score = 71.3 bits (167), Expect = 1e-11
Identities = 120/517 (23%), Positives = 242/517 (46%), Gaps = 62/517 (11%)
Query: 139 EILKELATKFRQSHNNIDF--NEIDRKLSKLRI---NNTNCHTEHNAVQGTDAEKVSAMI 193
E + EL+ + +DF N+ D +LR+ +N N H ++ D KV +++
Sbjct: 1743 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH-VIEDRD-RKVESLL 1800
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
N+M+ EL+ K + ++ K LE+++ DL EKL E
Sbjct: 1801 NEMK----ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1856
Query: 254 QRLEMVKGHHA-LALEANESIR--------------REYKIELEALKTKLDEEKQAIISK 298
QR+E +G ++ L + A++S R +E +++E +++ EK +I +
Sbjct: 1857 QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1916
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEK-CEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ +L+ + K+ K+K LE+ S + + +++ +L+ + + +
Sbjct: 1917 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1976
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD-------LKQE 410
++ E + +E++Q ++ H S+ IQ E E+KE L ++ S+ L+++
Sbjct: 1977 DQLSE-KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2035
Query: 411 LNNLKNCKDELSTEKF---NFIEEIKTLKDELIEKTINY-----ENEKNKLNL--AVEKA 460
L +L+ LS K N I ++ K+ L++++ + E++ KLN+ A+E A
Sbjct: 2036 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2095
Query: 461 IKEKNKFETSLSVTRDIVHVL-----TLRLR-ESDSE-----LEQLEDQVQMLTSAKEVL 509
+ EK +F LS T++ VH L LR+R E+D + E+L+++ + S K+ +
Sbjct: 2096 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2155
Query: 510 EN-ELTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRIMEHN-VTLIESLQNVE 566
EN E + N + D E +A V LK++ ++ E + VTL +N+
Sbjct: 2156 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2215
Query: 567 KEAYRELGTIK--NELIEDVE-LLKKESNSQIKFLRE 600
K+ + G + ++L+ + LL+++ ++I+ E
Sbjct: 2216 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2252
Score = 68.1 bits (159), Expect = 1e-10
Identities = 87/379 (22%), Positives = 164/379 (43%), Gaps = 30/379 (7%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR 255
+++R+ LE E+ D Q + EE++ ++ + ++L + ++ +AET QR
Sbjct: 827 LQNRVDSLEFSLESQKQMNSDLQKQC---EELVQIKGEIEENLMKAEQMHQSFVAETSQR 883
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
+ ++ + A++++ E L AL+ K ++E Q + K + +Q A I+
Sbjct: 884 ISKLQEDTS----AHQNVVAE---TLSALENK-EKELQLLNDKVETEQ--------AEIQ 927
Query: 316 SLK--NQMLKEKCEALEQLHSQLIIKEQEMKAKLE----QIEESASEKLKICEIQFEERS 369
LK N +L++ + L+ L L ++++EM + + +IEE E + EI +
Sbjct: 928 ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEIN-ASLN 986
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
Q + E Y+++ K + D + L Q N ++LS +
Sbjct: 987 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1046
Query: 430 EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD 489
E+ L+ L E T EN KN+L E KE +F T L+ + L L L
Sbjct: 1047 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ 1106
Query: 490 SEL-EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEY---KEALVNILKSKAALT 545
L ++ D S L+ E+ T K N +E ++ E L+ ++K+K
Sbjct: 1107 QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1166
Query: 546 KEHTRIMEHNVTLIESLQN 564
+ + ++V ES +N
Sbjct: 1167 NLESEPIRNSVKERESERN 1185
Score = 57.6 bits (133), Expect = 1e-07
Identities = 95/469 (20%), Positives = 205/469 (43%), Gaps = 23/469 (4%)
Query: 81 TKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
T A + + +TL+ +NK + EL D ++ + I E K ++ + +LQ +
Sbjct: 891 TSAHQNVVAETLSALENK---EKELQLLND-KVETEQAEIQELKKSNHLLEDSLKELQLL 946
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ L+ + ++ + I N+ R++ +L N E NA + + + I
Sbjct: 947 SETLSLEKKEMSSIISLNK--REIEELTQENGTLK-EINASLNQEKMNLIQKSESFANYI 1003
Query: 201 IELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLC---KDLQEKLTSNELTLAETQQRL 256
E EK L ++ +K + L EE + L K QEK + E L E
Sbjct: 1004 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1063
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
E K EA +E+ +L +E Q ++ + + Q+ L+++ + +
Sbjct: 1064 ENRKNELEQLKEAFAKEHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNN 1119
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
K++ LK++ L++ +++ + ++ + EQ+ + K + ++ E S++E
Sbjct: 1120 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1179
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
S++ + + +++ + +LD N Q L+ L N + E EK E++T
Sbjct: 1180 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1239
Query: 435 LKDELIEKTINYEN-EKNKLNLAVEKAIKEKNKFET---SLSVTRDIVHVLTLRLRESDS 490
++ +L +T N ++ + +++ + I + K+ + LS +++ L L+ + +
Sbjct: 1240 IRGDL--ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1297
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
+L +LE ++L + K L EL ++ R+ E L+N +K
Sbjct: 1298 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVK 1346
Score = 51.6 bits (118), Expect = 1e-05
Identities = 90/429 (20%), Positives = 187/429 (43%), Gaps = 49/429 (11%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQSI 372
E + N L+ K + E L +I++++ K + L +++E S KL + E+Q + ++
Sbjct: 1766 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS-KLHLQEVQLMTKIEA- 1823
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-----TEKFN 427
C + EK + L++E +L L+ + + +L Q + + +L + + +
Sbjct: 1824 ---CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1880
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL-R 486
+ + + D E+ ++ ENE +++ EKA E +L + D+ V T +L
Sbjct: 1881 IGDNVAKVNDSWKERFLDVENELSRIRS--EKASIEHE----ALYLEADLEVVQTEKLCL 1934
Query: 487 ESDSELEQ-----LEDQVQMLTSAKEVLENELTTY--KNT--------LNNTVRECDEYK 531
E D+E +Q LE+++ ++TS + L EL T K T + +E + ++
Sbjct: 1935 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1994
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
++ ++ A KE T +++ + + L + +L +++ + + + L K E
Sbjct: 1995 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCEL 2053
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXX 651
+QI L +E K+ ++ E V A AA + + E
Sbjct: 2054 ENQIAQLNKE--KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE--------FA 2103
Query: 652 XXXXSLVVELSLLRQENEELTMTVA----KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
S E+ LR+ E+L + + KQ I +KLK+ ++ L + L+
Sbjct: 2104 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2163
Query: 708 VGKENMQTI 716
+ +EN + +
Sbjct: 2164 MSEENQELV 2172
Score = 46.4 bits (105), Expect = 4e-04
Identities = 84/436 (19%), Positives = 177/436 (40%), Gaps = 24/436 (5%)
Query: 270 NESIRREYKIELEA--LKTKLDE--EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
NE + K+ L+ L TK++ E + I+ + K + +L K S +Q L ++
Sbjct: 1801 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK--LEYFSCDHQELLQR 1858
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKT 382
E E L+S L + K+ E I ++ + + K + E I+ + E
Sbjct: 1859 VETSEGLNSDLEMHAD--KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1916
Query: 383 IQYLEQEIKEL---KYTLDLTNNQNSD----LKQELNNLKNCKDELSTEKFNFIEE---I 432
YLE +++ + K L+ N L++EL+ + + +++L E ++ +
Sbjct: 1917 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1976
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRESDSE 491
L +++ EKT E+ +++ ++ A E K K E +++ D+ +L + + +
Sbjct: 1977 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE-K 2035
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
L+ LE Q L+ K LEN++ V+E + + L K ++K
Sbjct: 2036 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2095
Query: 552 MEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
+ L + ++E ++ I+ +L +E +K+ + L+E + L +
Sbjct: 2096 LVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2154
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
+++ A + +E + ++L LR E E L
Sbjct: 2155 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2214
Query: 672 TMTVAKQSSIIDKLKK 687
T + ++ + +L K
Sbjct: 2215 TKQIQEKQGQLSELDK 2230
Score = 38.7 bits (86), Expect = 0.072
Identities = 90/442 (20%), Positives = 185/442 (41%), Gaps = 51/442 (11%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLE---EVITVRDSLCKDLQEKLTSNELTLAETQQR 255
+I ELE + + L E +Q +L SLE + T + K L L E +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLKRENQRLMEICES 78
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
LE K + L+ ES + +L + K ++++ +Q + +CK + E + ++
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE-LKRCKSELERSQQAAQSADV 137
Query: 316 SLKNQMLKEKCEALEQLHSQLI--IKEQEMKAKL-EQIEESASEKLKICEIQFEERSQS- 371
SL +K SQ K +++K K +++EE + ++ +Q ++ SQ+
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 372 ---------IQEHCS-------QQEKTIQYLEQEIKELKYTLDLTNNQNS---DLKQELN 412
I H + QQEKT +L + D + + S ++ +
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 413 NLKNCKDELSTEKF------NFIEEIKTLKDELIEKTINYE--------------NEKNK 452
L+ K + ++ F + ++++K EL K E N+ +
Sbjct: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQE 317
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L L +EKA E + E L+ RD + T + ++ ++ LE +++ LT
Sbjct: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377
Query: 513 LTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQNVEKE 568
+ + +L ++E + E++E L +S L +E ++ + + +++ NV +
Sbjct: 378 AESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 569 AYRELGTIKNELIEDVELLKKE 590
+L ++K +L ++E K++
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQK 459
Score = 37.9 bits (84), Expect = 0.13
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 10/123 (8%)
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
+E L T+ I+ L+ Q+ K K E +Q QL E + + +++E +E +
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEK-QQRQFQLDSLEAAPQKQTQKVENEKTEGTNL-- 65
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCK 418
+ +Q + E C EKT Q + E++ + ++ Q + K+++ LK CK
Sbjct: 66 ---KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 419 DEL 421
EL
Sbjct: 123 SEL 125
>U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protein
protein.
Length = 3210
Score = 79.0 bits (186), Expect = 5e-14
Identities = 118/526 (22%), Positives = 240/526 (45%), Gaps = 52/526 (9%)
Query: 129 DYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG---TD 185
D K ++ LQ+ LKE ++ ++R+L R N + E +G T
Sbjct: 2409 DEKKQLCVLQQ-LKESEHHADLLKGRVE--NLERELEIARTNQEHAALEAENSKGEVETL 2465
Query: 186 AEKVSAMINDMRSR---IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEK 241
K+ M +R ++ + + E L NE+ +Q +S LE + + +++ ++ QEK
Sbjct: 2466 KAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEK 2525
Query: 242 LTSNELTLAETQQRLEMVK--GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ E + + +K AL ++ + + L + L+ EK ++
Sbjct: 2526 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2585
Query: 300 KVDQEN---LKTKHNASIESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE--- 351
+ N L++ N I+ +++ Q L++K E + +L +Q+ +EQ + +KL Q+E
Sbjct: 2586 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-LVSKLSQVEGEH 2644
Query: 352 ---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+ + +L+ ++ E++ Q +Q + + T++ L+ K L+ L+LT
Sbjct: 2645 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2704
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA---IKEKN 465
+++N + + EL E ++ L++EL + E L ++ + +KE
Sbjct: 2705 EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2764
Query: 466 KFETSLSVTRDIVHVLTL----RLRESDSE----LEQLEDQVQ-MLTSAKEVLENELTTY 516
+ L + D +H + ++RE +E L + E + Q +L + E E+ TY
Sbjct: 2765 LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY 2824
Query: 517 KNTLNNTVRECDEYKEALVNILK-SKAALT---KEHTRIMEH-NVTLIESLQNV---EKE 568
+ L + EC ++ +++LK SK L K T+I+E T +++L+ V +KE
Sbjct: 2825 REKLTSK-EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2883
Query: 569 AYRELGTIK------NELIEDVELLKKESNSQIKFLREEVEKKRVL 608
R G +K +L E+ E+L+KE SQ++ +E+ + V+
Sbjct: 2884 NERAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVM 2928
Score = 78.2 bits (184), Expect = 1e-13
Identities = 120/620 (19%), Positives = 257/620 (41%), Gaps = 33/620 (5%)
Query: 80 ITKAPNSSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
I A NS + +TL ++ ++ + V +R++ + + KQI++ + ++++L
Sbjct: 2270 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL---TKQIQEKQGQLSELD 2326
Query: 139 EILKELATKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
++L + + I E + ++ N E A D E + A +
Sbjct: 2327 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2386
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
I E + ++ E ++E +++ ++ + L + E + +
Sbjct: 2387 PPIEEEHQLRNSI--EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2444
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
HA ALEA S K E+E LK K++ Q++ ++D ++++ E L
Sbjct: 2445 RTNQEHA-ALEAENS-----KGEVETLKAKIEGMTQSLRG-LELDVVTIRSEK----EDL 2493
Query: 318 KNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH 375
N++ KE + LE ++S QE + + Q++E +S +++ + Q +E ++ +
Sbjct: 2494 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL 2553
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTL 435
+ QE + EQ + L+L + + L Q L+ KN L + I+E++
Sbjct: 2554 HNDQE-ACKAKEQNLSSQVECLEL---EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 2609
Query: 436 KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL 495
K +L +K KN++ E+ + + ++ E + ++ L E + +++ L
Sbjct: 2610 KQKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL 2668
Query: 496 EDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
+ + L EVL++ +N L T + + E + + + L +E + +
Sbjct: 2669 QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 2728
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES--NSQIK-----FLREEVEKKRVL 608
L E L + EL + E+ + LK+ + NS++K +++VEK+ +
Sbjct: 2729 AELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKV 2788
Query: 609 CEMXXXXXXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQE 667
E + LL ++ E+ S +E+ LL+
Sbjct: 2789 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 2848
Query: 668 NEELTMTVAKQSSIIDKLKK 687
EEL ++ + I+++LKK
Sbjct: 2849 KEELNNSLKATTQILEELKK 2868
Score = 75.4 bits (177), Expect = 7e-13
Identities = 87/335 (25%), Positives = 169/335 (50%), Gaps = 42/335 (12%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ L +++ + +L + Q++E+RN T+ E ++I+ +++ A LQ+ L+ L + +
Sbjct: 2630 QEQLVSKLSQVEGEHQLWKEQNLELRNL--TV-ELEQKIQVLQSKNASLQDTLEVLQSSY 2686
Query: 149 RQSHNNIDFNEIDR-----KLSKLRINNTNCHTE-HNAVQGTDA--EKVSAMINDMRSRI 200
+ N ++ ++D+ K++K+ T E H Q T E++S N + +
Sbjct: 2687 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGEL 2746
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL-EMV 259
L ++ ++ +++ + +E S L++ + D + KD EK +AE Q RL E
Sbjct: 2747 QLLLEEIKSSKDQLKELTLENSELKKSL---DCMHKDQVEKEGKVREEIAEYQLRLHEAE 2803
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
K H AL L+ N ++Y++E++ + KL +++ + S+ K++ + LK+ S E L N
Sbjct: 2804 KKHQALLLDTN----KQYEVEIQTYREKLTSKEECLSSQ-KLEIDLLKS----SKEELNN 2854
Query: 320 QMLKEKCEALEQLHSQLI--IKE-QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
LK + LE+L + +K ++K + E+ + +K C+ Q EE + +Q+
Sbjct: 2855 S-LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK-QLEEEKEILQKEL 2912
Query: 377 SQ----QEKT---------IQYLEQEIKELKYTLD 398
SQ QEK + L EIKELK TL+
Sbjct: 2913 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2947
Score = 74.9 bits (176), Expect = 9e-13
Identities = 132/549 (24%), Positives = 230/549 (41%), Gaps = 55/549 (10%)
Query: 89 KKTL-TCPKN---KILPQDELVQAQDVEIRNKDQTICEYNKQIE--DYKNEIAQLQEILK 142
+KTL +C K+ K+L Q E + ++++ + C +QI+ +Y + L+ +
Sbjct: 615 EKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 673
Query: 143 ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRII 201
L+ + R HN +D ++ + KL E + + + E + + + ++
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE K + L NE+ DK L E ++RD L K L +NE +
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD-LLKSKDASLVTNEDHQRSLLAFDQQPA 792
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLK- 318
HH+ A E + E + + D+ K + I + +VD S+ES K
Sbjct: 793 MHHSFANIIGE--QGSMPSERSECRLEADQSPKNSAILQNRVDSLEF------SLESQKQ 844
Query: 319 -NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQS--IQ 373
N L+++CE L Q+ + I+E MKA EQ+ +S A +I ++Q + + +
Sbjct: 845 MNSDLQKQCEELVQIKGE--IEENLMKA--EQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 374 EHCS---QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
E S +EK +Q L +++ + + N L+ L L+ + LS EK
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 431 EIKTLKDELIE--------KTINYENEKNKLNLAVEKA------IKEKNKFETSLS-VTR 475
I K E+ E K IN + K+NL ++K+ I E+ K + LS +
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNL-IQKSESFANYIDEREKSISELSDQYK 1019
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+L R E+ + E L + + LE L + N E ++ KEA
Sbjct: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ + LTK E N L+ L+ V++ E+ +N + LK+E I
Sbjct: 1080 K--EHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE----I 1132
Query: 596 KFLREEVEK 604
L+EE K
Sbjct: 1133 MTLKEEQNK 1141
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/525 (22%), Positives = 231/525 (44%), Gaps = 60/525 (11%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE-----LATKFRQ 150
+NKI + +Q + E++ + E Q+E K E+ + +++L + + T +
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 151 SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
+ + +++KL KL TE + Q +AE S LE+K +
Sbjct: 351 DQASTKYTALEQKLKKL--------TEDLSCQRQNAE----------SARCSLEQKIKEK 392
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
+ E Q ELS + D C ++ +LT E QQ M H+ L E +
Sbjct: 393 EKEF---QEELSRQQRSFQTLDQECIQMKARLTQ------ELQQAKNM---HNVLQAELD 440
Query: 271 E--SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKC 326
+ S++++ + LE K KL +QA ++ + L+ S+E +K N +LK
Sbjct: 441 KLTSVKQQLENNLEEFKQKLCRAEQA-FQASQIKENELR----RSMEEMKKENNLLKSHS 495
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK--TIQ 384
E + L + + +K L Q ++ +E++K E + +QE +QQE T++
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQ-SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-TEKFNFIEEIKTLKDELIEKT 443
L+ + +L+ D + + LK+ ++++ D+LS TEK E K L L K
Sbjct: 555 KLKLAVADLEKQRDCSQDL---LKKREHHIEQLNDKLSKTEK-----ESKALLSALELKK 606
Query: 444 INYENEKNKLNL-AVEKAIKEK--NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
YE K + L + K+ EK + E+ + ++ L L+ + + ++V+
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L +E L E+ N L++ E + K A + + + ++H + +E+
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
L ++ +L + NE++ D + ++ +++ + LR+ ++ K
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIM-DKDRCYQDLHAEYESLRDLLKSK 770
Score = 71.3 bits (167), Expect = 1e-11
Identities = 120/517 (23%), Positives = 242/517 (46%), Gaps = 62/517 (11%)
Query: 139 EILKELATKFRQSHNNIDF--NEIDRKLSKLRI---NNTNCHTEHNAVQGTDAEKVSAMI 193
E + EL+ + +DF N+ D +LR+ +N N H ++ D KV +++
Sbjct: 1840 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH-VIEDRD-RKVESLL 1897
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
N+M+ EL+ K + ++ K LE+++ DL EKL E
Sbjct: 1898 NEMK----ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1953
Query: 254 QRLEMVKGHHA-LALEANESIR--------------REYKIELEALKTKLDEEKQAIISK 298
QR+E +G ++ L + A++S R +E +++E +++ EK +I +
Sbjct: 1954 QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 2013
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEK-CEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ +L+ + K+ K+K LE+ S + + +++ +L+ + + +
Sbjct: 2014 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 2073
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD-------LKQE 410
++ E + +E++Q ++ H S+ IQ E E+KE L ++ S+ L+++
Sbjct: 2074 DQLSE-KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2132
Query: 411 LNNLKNCKDELSTEKF---NFIEEIKTLKDELIEKTINY-----ENEKNKLNL--AVEKA 460
L +L+ LS K N I ++ K+ L++++ + E++ KLN+ A+E A
Sbjct: 2133 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2192
Query: 461 IKEKNKFETSLSVTRDIVHVL-----TLRLR-ESDSE-----LEQLEDQVQMLTSAKEVL 509
+ EK +F LS T++ VH L LR+R E+D + E+L+++ + S K+ +
Sbjct: 2193 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2252
Query: 510 EN-ELTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRIMEHN-VTLIESLQNVE 566
EN E + N + D E +A V LK++ ++ E + VTL +N+
Sbjct: 2253 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2312
Query: 567 KEAYRELGTIK--NELIEDVE-LLKKESNSQIKFLRE 600
K+ + G + ++L+ + LL+++ ++I+ E
Sbjct: 2313 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2349
Score = 68.1 bits (159), Expect = 1e-10
Identities = 87/379 (22%), Positives = 164/379 (43%), Gaps = 30/379 (7%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR 255
+++R+ LE E+ D Q + EE++ ++ + ++L + ++ +AET QR
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQC---EELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
+ ++ + A++++ E L AL+ K ++E Q + K + +Q A I+
Sbjct: 885 ISKLQEDTS----AHQNVVAE---TLSALENK-EKELQLLNDKVETEQ--------AEIQ 928
Query: 316 SLK--NQMLKEKCEALEQLHSQLIIKEQEMKAKLE----QIEESASEKLKICEIQFEERS 369
LK N +L++ + L+ L L ++++EM + + +IEE E + EI +
Sbjct: 929 ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEIN-ASLN 987
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
Q + E Y+++ K + D + L Q N ++LS +
Sbjct: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1047
Query: 430 EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD 489
E+ L+ L E T EN KN+L E KE +F T L+ + L L L
Sbjct: 1048 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ 1107
Query: 490 SEL-EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEY---KEALVNILKSKAALT 545
L ++ D S L+ E+ T K N +E ++ E L+ ++K+K
Sbjct: 1108 QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1167
Query: 546 KEHTRIMEHNVTLIESLQN 564
+ + ++V ES +N
Sbjct: 1168 NLESEPIRNSVKERESERN 1186
Score = 57.6 bits (133), Expect = 1e-07
Identities = 95/469 (20%), Positives = 205/469 (43%), Gaps = 23/469 (4%)
Query: 81 TKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
T A + + +TL+ +NK + EL D ++ + I E K ++ + +LQ +
Sbjct: 892 TSAHQNVVAETLSALENK---EKELQLLND-KVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ L+ + ++ + I N+ R++ +L N E NA + + + I
Sbjct: 948 SETLSLEKKEMSSIISLNK--REIEELTQENGTLK-EINASLNQEKMNLIQKSESFANYI 1004
Query: 201 IELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLC---KDLQEKLTSNELTLAETQQRL 256
E EK L ++ +K + L EE + L K QEK + E L E
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
E K EA +E+ +L +E Q ++ + + Q+ L+++ + +
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
K++ LK++ L++ +++ + ++ + EQ+ + K + ++ E S++E
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
S++ + + +++ + +LD N Q L+ L N + E EK E++T
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240
Query: 435 LKDELIEKTINYEN-EKNKLNLAVEKAIKEKNKFET---SLSVTRDIVHVLTLRLRESDS 490
++ +L +T N ++ + +++ + I + K+ + LS +++ L L+ + +
Sbjct: 1241 IRGDL--ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
+L +LE ++L + K L EL ++ R+ E L+N +K
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVK 1347
Score = 51.6 bits (118), Expect = 1e-05
Identities = 90/429 (20%), Positives = 187/429 (43%), Gaps = 49/429 (11%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQSI 372
E + N L+ K + E L +I++++ K + L +++E S KL + E+Q + ++
Sbjct: 1863 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS-KLHLQEVQLMTKIEA- 1920
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-----TEKFN 427
C + EK + L++E +L L+ + + +L Q + + +L + + +
Sbjct: 1921 ---CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1977
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL-R 486
+ + + D E+ ++ ENE +++ EKA E +L + D+ V T +L
Sbjct: 1978 IGDNVAKVNDSWKERFLDVENELSRIRS--EKASIEHE----ALYLEADLEVVQTEKLCL 2031
Query: 487 ESDSELEQ-----LEDQVQMLTSAKEVLENELTTY--KNT--------LNNTVRECDEYK 531
E D+E +Q LE+++ ++TS + L EL T K T + +E + ++
Sbjct: 2032 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 2091
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
++ ++ A KE T +++ + + L + +L +++ + + + L K E
Sbjct: 2092 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCEL 2150
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXX 651
+QI L +E K+ ++ E V A AA + + E
Sbjct: 2151 ENQIAQLNKE--KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE--------FA 2200
Query: 652 XXXXSLVVELSLLRQENEELTMTVA----KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
S E+ LR+ E+L + + KQ I +KLK+ ++ L + L+
Sbjct: 2201 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2260
Query: 708 VGKENMQTI 716
+ +EN + +
Sbjct: 2261 MSEENQELV 2269
Score = 46.4 bits (105), Expect = 4e-04
Identities = 84/436 (19%), Positives = 177/436 (40%), Gaps = 24/436 (5%)
Query: 270 NESIRREYKIELEA--LKTKLDE--EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
NE + K+ L+ L TK++ E + I+ + K + +L K S +Q L ++
Sbjct: 1898 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK--LEYFSCDHQELLQR 1955
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKT 382
E E L+S L + K+ E I ++ + + K + E I+ + E
Sbjct: 1956 VETSEGLNSDLEMHAD--KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 2013
Query: 383 IQYLEQEIKEL---KYTLDLTNNQNSD----LKQELNNLKNCKDELSTEKFNFIEE---I 432
YLE +++ + K L+ N L++EL+ + + +++L E ++ +
Sbjct: 2014 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 2073
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRESDSE 491
L +++ EKT E+ +++ ++ A E K K E +++ D+ +L + + +
Sbjct: 2074 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE-K 2132
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
L+ LE Q L+ K LEN++ V+E + + L K ++K
Sbjct: 2133 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2192
Query: 552 MEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
+ L + ++E ++ I+ +L +E +K+ + L+E + L +
Sbjct: 2193 LVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2251
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
+++ A + +E + ++L LR E E L
Sbjct: 2252 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2311
Query: 672 TMTVAKQSSIIDKLKK 687
T + ++ + +L K
Sbjct: 2312 TKQIQEKQGQLSELDK 2327
Score = 38.7 bits (86), Expect = 0.072
Identities = 90/442 (20%), Positives = 185/442 (41%), Gaps = 51/442 (11%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLE---EVITVRDSLCKDLQEKLTSNELTLAETQQR 255
+I ELE + + L E +Q +L SLE + T + K L L E +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLKRENQRLMEICES 78
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
LE K + L+ ES + +L + K ++++ +Q + +CK + E + ++
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE-LKRCKSELERSQQAAQSADV 137
Query: 316 SLKNQMLKEKCEALEQLHSQLI--IKEQEMKAKL-EQIEESASEKLKICEIQFEERSQS- 371
SL +K SQ K +++K K +++EE + ++ +Q ++ SQ+
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 372 ---------IQEHCS-------QQEKTIQYLEQEIKELKYTLDLTNNQNS---DLKQELN 412
I H + QQEKT +L + D + + S ++ +
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGELEVTPSRS 257
Query: 413 NLKNCKDELSTEKF------NFIEEIKTLKDELIEKTINYE--------------NEKNK 452
L+ K + ++ F + ++++K EL K E N+ +
Sbjct: 258 TLQIGKRDANSSFFGNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQE 317
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L L +EKA E + E L+ RD + T + ++ ++ LE +++ LT
Sbjct: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377
Query: 513 LTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQNVEKE 568
+ + +L ++E + E++E L +S L +E ++ + + +++ NV +
Sbjct: 378 AESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 569 AYRELGTIKNELIEDVELLKKE 590
+L ++K +L ++E K++
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQK 459
Score = 37.9 bits (84), Expect = 0.13
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 10/123 (8%)
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
+E L T+ I+ L+ Q+ K K E +Q QL E + + +++E +E +
Sbjct: 9 KEGLPTRTLQKIQELEGQLDKLKKEK-QQRQFQLDSLEAAPQKQTQKVENEKTEGTNL-- 65
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCK 418
+ +Q + E C EKT Q + E++ + ++ Q + K+++ LK CK
Sbjct: 66 ---KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 419 DEL 421
EL
Sbjct: 123 SEL 125
>BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein.
Length = 1843
Score = 79.0 bits (186), Expect = 5e-14
Identities = 132/621 (21%), Positives = 254/621 (40%), Gaps = 42/621 (6%)
Query: 85 NSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYK---NEIAQLQEIL 141
N +KKTL KN + L + E D+ E + +E K ++AQLQ
Sbjct: 672 NRKLKKTLDSFKNLTFQLESL----EKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 142 KELATKFRQSHNNIDFNEID-RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
KEL ++ Q ++ + +K +L ++ E+ +Q T E + I + S +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT-LENSNKKIQQLESEL 786
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE + + L + + ++ LE++ SL ++ + L ++ L + +RL
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ-LEKDKKQLEKENKRLRQQA 845
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
LE N + E + L ++ K++ + ++++EN + A+I+
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 321 MLKEKCEALEQLHSQLIIKEQE-MKAKLEQIEESASEKLKICEIQFEERSQSIQEHC-SQ 378
L+E + E+L +Q + + E + +LE+I + L + + R + ++ S
Sbjct: 906 TLREDLVS-EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
Query: 379 QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE 438
+K+++ E++I L+ L+ + N N L+QEL +K N+ E +K +DE
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK----------NY-EALKQRQDE 1013
Query: 439 --LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+++ + E NK ++ +E K + L L + ++L+QLE
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1073
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
Q L + ++L + T NT + K + N + L + T +M N
Sbjct: 1074 TQNNNLQA--QILALQRQTVSLQEQNTTLQTQNAKLQVEN-----STLNSQSTSLMNQNA 1126
Query: 557 TLI---ESLQNVEKEAYRE---LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
L+ SL+N + +E L ++ + LI+D E L+ Q + K L
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS 1186
Query: 611 MXXXXXXXXXXXXXXSRVLLAQAA--ADLSR-LENENERYXXXXXXXXSLVVELSLLRQE 667
LL Q DL + L+ E E+ ++ E L E
Sbjct: 1187 AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1246
Query: 668 NEELTMTVAKQSSIIDKLKKD 688
N+ L T ++ + L+ D
Sbjct: 1247 NDRLNHTYSQLLKETEVLQTD 1267
Score = 72.9 bits (171), Expect = 4e-12
Identities = 132/669 (19%), Positives = 293/669 (43%), Gaps = 65/669 (9%)
Query: 73 ATPKAFKITKAPNSSIKKTLTCPKNKILPQDEL--VQAQDVEIRNKDQTICEYNKQIEDY 130
A K ++ + ++ L C + + EL +Q +++ + + ++ Y +++
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTD 185
+ + ++ ++ E++ ++++ ++I+F + ++ +L+ +N T E + ++GT
Sbjct: 316 REKAVRVDKLESEVS-RYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLE-DQLEGTR 371
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
A S ++++ ++L+ K ++ E D++ +EE +T+ + + + E L
Sbjct: 372 AR--SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 245 N-ELT-LAETQQRLEMVK---GHHALALEANESIRREYKIE-----LEALKTKLDEEKQA 294
EL ++ T + E + GH L ++ ++ E + + +E L+T +D +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEE 352
K+++EN + + +E L+N++++EK + + L L+ ++ +++ +E + E
Sbjct: 490 ASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 353 SASEKLKICEIQFE----------ERSQ-SIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ ++KI E + E +RSQ S + EK + L + IKE L
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+ +K+EL + K K E + E N + ++ + L +K N + K+ A+E+
Sbjct: 608 FEKRQIKKELEHYKE-KGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQEN 665
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL-EDQVQMLTSAKEVLENELTTYKNTL 520
E + L T D LT +L + E QL E+ +++ + + + + + L
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 521 NNTVRECDEYKEALVNILK-SKAALTKEHTRIMEHNVTLIES--LQNVEKEAYRELGTIK 577
N +E + KE L L+ KA+ K + + IE+ LQ + + +++ ++
Sbjct: 726 EN--KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 578 NELIEDVELLKKESNSQIKFLR------EEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLA 631
+EL +D+E+ + ++ L+ E++EK+ E L
Sbjct: 784 SEL-QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 632 QAA-----------ADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
Q A + LE EN+ V L L +EN+EL
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 681 IIDKLKKDL 689
+ L++DL
Sbjct: 903 TLVTLREDL 911
Score = 71.3 bits (167), Expect = 1e-11
Identities = 129/635 (20%), Positives = 272/635 (42%), Gaps = 68/635 (10%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ D K +I +L++ L+E + ++ EI+ L +L+ N N ++ + +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE--LKRLQQENMNLLSDARSARMYR 309
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
E ++ +R + + ++K L++EV + L +E K E+L +
Sbjct: 310 DE-----LDALREKAVRVDK----LESEVSRYKERLHDIE--------FYKARVEELKED 352
Query: 246 ELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQ 303
L ET+ LE ++G A + + +E + + LK KL D E + + + K+++
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEE 407
Query: 304 ENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
+ N ++E + Q + E LEQ+ + E K+ ++ E S +L
Sbjct: 408 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 361 CEIQFEERSQSIQEHCSQQEKT------IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E++ + +++++E + + I +E+E + L +++ N+ KQ L N
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+N +L EK + I+TL++ + E E LN V +++++++ V
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS-SLRQRSQISAEARV- 582
Query: 475 RDIVH---VLTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECD 528
+DI +L ++E+ S+L ++E + + + E + + +N L++ +E +
Sbjct: 583 KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE 642
Query: 529 EYKEALVNI---LKSKAALTKEHTRIMEHNVTLIESL----------QNVEKEAYRELGT 575
++ + N+ + AL +E++ + N L ++L +++EKE +L
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN-SQLDE 701
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAA 635
EL +VE LK S + E E + ++ R+ ++
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 636 DLSR------LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
D+ LEN N++ L +E L++ EEL ++ +K+ ++K K L
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL 820
Query: 690 EQ-SQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
EQ + K L K K ++ + E N
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Score = 59.3 bits (137), Expect = 5e-08
Identities = 122/570 (21%), Positives = 245/570 (42%), Gaps = 54/570 (9%)
Query: 70 LKFATPKAFKITKAPNSSIKKTLTCPKNKI-LPQDELVQAQDVEIRNKDQTICEYNKQIE 128
LK ++ + ++ K S ++T K+K L ++ Q EI KD T+ E N +I
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KDTTLEENNVKIG 860
Query: 129 DYKNEIAQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
+ + E L + I KE + ++ N+ K + + I T + V ++
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKE---NKELVKRATIDIK-TLVTLREDLV--SE 914
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
K M ND+ ELEK + ++D+Q S +++ L L++ L
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL--ESKLESTLKKSLEIK 972
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
E +A + RLE ++ + +++++ Y EALK + DEE+ + S + E+
Sbjct: 973 EEKIAALEARLEESTNYNQQLRQELKTVKKNY----EALKQRQDEERM-VQSSPPISGED 1027
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE-ESASEKLKICEIQ 364
K + + + + +K++ +E+ ++ L ++Q +K +L+Q+E ++ + + +I +Q
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 365 -----FEERSQSIQ--------EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL 411
+E++ ++Q E+ + ++ + Q + L L N S +K E
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK-ER 1146
Query: 412 NNLKNCKDEL--STEKFNFIEEIKTLKDE-LIEK--TI-----NYENEKNKLNLAVEKAI 461
+LK+ D L EK + E + + E LI K T+ N E E L + +
Sbjct: 1147 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1206
Query: 462 KEKNKFET---SLSVTRDIV-------HVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
K+K + E L V ++ + + ++ E ++L L EVL+
Sbjct: 1207 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1266
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
+ K+ LNN+ E + + + L T++ L + N+E+E
Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREE 601
L I+ ++++ LL++ S+ F E+
Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQ 1356
Score = 53.6 bits (123), Expect = 2e-06
Identities = 82/419 (19%), Positives = 185/419 (44%), Gaps = 37/419 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQ---DVEIRNKDQTI---CEYNKQIEDYKNEIAQLQE 139
S++KK+L + KI + ++ + ++R + +T+ E KQ +D + +
Sbjct: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
Query: 140 ILKELATKFRQSHNNI-DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
I E R+S + ++ +L ++ NN E A++ T +++ N++++
Sbjct: 1023 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK-TQLKQLETQNNNLQA 1081
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I+ L+++ +L + Q + + L+ + +S L + + + + E
Sbjct: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK---CKVDQENLKTKHNASIE 315
V +S+ ++++ +LE L + E +++ISK K +NL+ +H +E
Sbjct: 1142 VIKEREDLKSLYDSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-DLE 1199
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE------------- 362
NQ+LK+K + LE L L +++++M + + E A+E K+C
Sbjct: 1200 DRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1258
Query: 363 -----IQFEERSQSIQEHCSQQEKT-----IQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+Q + ++ + S+ E+T L+++ ++L T NNQ L Q
Sbjct: 1259 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318
Query: 413 NLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
NL+ L + + + +TL ++ +E + E+ + + + ++K K E +
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
Score = 50.8 bits (116), Expect = 2e-05
Identities = 97/404 (24%), Positives = 174/404 (43%), Gaps = 46/404 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V+ + ++ + Q + KQ+E N + Q Q + + T Q N + + +
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNL-QAQILALQRQTVSLQEQNTT----LQTQNA 1105
Query: 166 KLRINNTNCHTEHNAVQGTDAEKV---SAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
KL++ N+ +++ ++ +A+ + S++ N+ S I E E D+ + D + +L
Sbjct: 1106 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KLE 1164
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E R + E L S TL + LE+ H L N+ ++++ ++E
Sbjct: 1165 LLHE----RQA---SEYESLISKHGTLKSAHKNLEVE--HRDLEDRYNQLLKQKGQLEDL 1215
Query: 283 ALKTKLDEEKQAIISKCK--VDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
K+++EK + +K V E K N + +Q+LKE E L+ H L K
Sbjct: 1216 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNL--K 1272
Query: 340 EQEMKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+KLEQ E+ KLK Q + S + C + LE+E + L +
Sbjct: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1332
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTIN----YE---- 447
QN L ++ N+++ KD E+ +I+ E++ K++L EK ++ Y+
Sbjct: 1333 TLMLQNRTLLEQ--NMES-KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPP 1389
Query: 448 -NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
N + L + K IK K + R+ LTL SDS
Sbjct: 1390 RRRGNWITLKMRKLIKSKK------DINRERQKSLTLTPTRSDS 1427
>AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 79.0 bits (186), Expect = 5e-14
Identities = 121/619 (19%), Positives = 256/619 (41%), Gaps = 31/619 (5%)
Query: 80 ITKAPNSSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
I A NS + +TL ++ ++ + V +R++ + + KQI++ + ++++L
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL---TKQIQEKQGQLSELD 2230
Query: 139 EILKELATKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
++L + + I E + ++ N E A D E + A +
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
I E + ++ E ++E +++ ++ + L + E + +
Sbjct: 2291 PPIEEEHQLRNSI--EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIES 316
HA ALEA S K E+E LK K++ Q++ ++D +++ K N + E
Sbjct: 2349 RTNQEHA-ALEAENS-----KGEVETLKAKIEGMTQSLRG-LELDVVTIRSEKENLTNEL 2401
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
K Q E+ LE ++S QE + + Q++E +S +++ + Q +E ++ +
Sbjct: 2402 QKEQ---ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALH 2458
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
+ QE + EQ + L+L + + L Q L+ KN L + I+E++ K
Sbjct: 2459 NDQE-ACKAKEQNLSSQVECLEL---EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+L +K KN++ E+ + + ++ E + ++ L E + +++ L+
Sbjct: 2515 QKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+ L EVL++ +N L T + + E + + + L +E + +
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKES--NSQIK-----FLREEVEKKRVLC 609
L E L + EL + E+ + LK+ + NS++K +++VEK+ +
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQEN 668
E + LL ++ E+ S +E+ LL+
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 669 EELTMTVAKQSSIIDKLKK 687
EEL ++ + I+++LKK
Sbjct: 2754 EELNNSLKATTQILEELKK 2772
Score = 79.0 bits (186), Expect = 5e-14
Identities = 118/526 (22%), Positives = 240/526 (45%), Gaps = 52/526 (9%)
Query: 129 DYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG---TD 185
D K ++ LQ+ LKE ++ ++R+L R N + E +G T
Sbjct: 2313 DEKKQLCVLQQ-LKESEHHADLLKGRVE--NLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 186 AEKVSAMINDMRSR---IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEK 241
K+ M +R ++ + + E L NE+ +Q +S LE + + +++ ++ QEK
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429
Query: 242 LTSNELTLAETQQRLEMVK--GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ E + + +K AL ++ + + L + L+ EK ++
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
Query: 300 KVDQEN---LKTKHNASIESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE--- 351
+ N L++ N I+ +++ Q L++K E + +L +Q+ +EQ + +KL Q+E
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-LVSKLSQVEGEH 2548
Query: 352 ---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+ + +L+ ++ E++ Q +Q + + T++ L+ K L+ L+LT
Sbjct: 2549 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2608
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA---IKEKN 465
+++N + + EL E ++ L++EL + E L ++ + +KE
Sbjct: 2609 EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
Query: 466 KFETSLSVTRDIVHVLTL----RLRESDSE----LEQLEDQVQ-MLTSAKEVLENELTTY 516
+ L + D +H + ++RE +E L + E + Q +L + E E+ TY
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY 2728
Query: 517 KNTLNNTVRECDEYKEALVNILK-SKAALT---KEHTRIMEH-NVTLIESLQNV---EKE 568
+ L + EC ++ +++LK SK L K T+I+E T +++L+ V +KE
Sbjct: 2729 REKLTSK-EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2787
Query: 569 AYRELGTIK------NELIEDVELLKKESNSQIKFLREEVEKKRVL 608
R G +K +L E+ E+L+KE SQ++ +E+ + V+
Sbjct: 2788 NERAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVM 2832
Score = 75.4 bits (177), Expect = 7e-13
Identities = 87/335 (25%), Positives = 169/335 (50%), Gaps = 42/335 (12%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ L +++ + +L + Q++E+RN T+ E ++I+ +++ A LQ+ L+ L + +
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNL--TV-ELEQKIQVLQSKNASLQDTLEVLQSSY 2590
Query: 149 RQSHNNIDFNEIDR-----KLSKLRINNTNCHTE-HNAVQGTDA--EKVSAMINDMRSRI 200
+ N ++ ++D+ K++K+ T E H Q T E++S N + +
Sbjct: 2591 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGEL 2650
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL-EMV 259
L ++ ++ +++ + +E S L++ + D + KD EK +AE Q RL E
Sbjct: 2651 QLLLEEIKSSKDQLKELTLENSELKKSL---DCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
K H AL L+ N ++Y++E++ + KL +++ + S+ K++ + LK+ S E L N
Sbjct: 2708 KKHQALLLDTN----KQYEVEIQTYREKLTSKEECLSSQ-KLEIDLLKS----SKEELNN 2758
Query: 320 QMLKEKCEALEQLHSQLI--IKE-QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
LK + LE+L + +K ++K + E+ + +K C+ Q EE + +Q+
Sbjct: 2759 S-LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK-QLEEEKEILQKEL 2816
Query: 377 SQ----QEKT---------IQYLEQEIKELKYTLD 398
SQ QEK + L EIKELK TL+
Sbjct: 2817 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Score = 74.9 bits (176), Expect = 9e-13
Identities = 132/549 (24%), Positives = 230/549 (41%), Gaps = 55/549 (10%)
Query: 89 KKTL-TCPKN---KILPQDELVQAQDVEIRNKDQTICEYNKQIE--DYKNEIAQLQEILK 142
+KTL +C K+ K+L Q E + ++++ + C +QI+ +Y + L+ +
Sbjct: 615 EKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 673
Query: 143 ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRII 201
L+ + R HN +D ++ + KL E + + + E + + + ++
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE K + L NE+ DK L E ++RD L K L +NE +
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD-LLKSKDASLVTNEDHQRSLLAFDQQPA 792
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLK- 318
HH+ A E + E + + D+ K + I + +VD S+ES K
Sbjct: 793 MHHSFANIIGE--QGSMPSERSECRLEADQSPKNSAILQNRVDSLEF------SLESQKQ 844
Query: 319 -NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQS--IQ 373
N L+++CE L Q+ + I+E MKA EQ+ +S A +I ++Q + + +
Sbjct: 845 MNSDLQKQCEELVQIKGE--IEENLMKA--EQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 374 EHCS---QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
E S +EK +Q L +++ + + N L+ L L+ + LS EK
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 431 EIKTLKDELIE--------KTINYENEKNKLNLAVEKA------IKEKNKFETSLS-VTR 475
I K E+ E K IN + K+NL ++K+ I E+ K + LS +
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNL-IQKSESFANYIDEREKSISELSDQYK 1019
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+L R E+ + E L + + LE L + N E ++ KEA
Sbjct: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ + LTK E N L+ L+ V++ E+ +N + LK+E I
Sbjct: 1080 K--EHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE----I 1132
Query: 596 KFLREEVEK 604
L+EE K
Sbjct: 1133 MTLKEEQNK 1141
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/525 (22%), Positives = 231/525 (44%), Gaps = 60/525 (11%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE-----LATKFRQ 150
+NKI + +Q + E++ + E Q+E K E+ + +++L + + T +
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 151 SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
+ + +++KL KL TE + Q +AE S LE+K +
Sbjct: 351 DQASTKYTALEQKLKKL--------TEDLSCQRQNAE----------SARCSLEQKIKEK 392
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
+ E Q ELS + D C ++ +LT E QQ M H+ L E +
Sbjct: 393 EKEF---QEELSRQQRSFQTLDQECIQMKARLTQ------ELQQAKNM---HNVLQAELD 440
Query: 271 E--SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKC 326
+ S++++ + LE K KL +QA ++ + L+ S+E +K N +LK
Sbjct: 441 KLTSVKQQLENNLEEFKQKLCRAEQA-FQASQIKENELR----RSMEEMKKENNLLKSHS 495
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK--TIQ 384
E + L + + +K L Q ++ +E++K E + +QE +QQE T++
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQ-SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-TEKFNFIEEIKTLKDELIEKT 443
L+ + +L+ D + + LK+ ++++ D+LS TEK E K L L K
Sbjct: 555 KLKLAVADLEKQRDCSQDL---LKKREHHIEQLNDKLSKTEK-----ESKALLSALELKK 606
Query: 444 INYENEKNKLNL-AVEKAIKEK--NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
YE K + L + K+ EK + E+ + ++ L L+ + + ++V+
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L +E L E+ N L++ E + K A + + + ++H + +E+
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
L ++ +L + NE++ D + ++ +++ + LR+ ++ K
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIM-DKDRCYQDLHAEYESLRDLLKSK 770
Score = 71.3 bits (167), Expect = 1e-11
Identities = 120/517 (23%), Positives = 242/517 (46%), Gaps = 62/517 (11%)
Query: 139 EILKELATKFRQSHNNIDF--NEIDRKLSKLRI---NNTNCHTEHNAVQGTDAEKVSAMI 193
E + EL+ + +DF N+ D +LR+ +N N H ++ D KV +++
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH-VIEDRD-RKVESLL 1801
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
N+M+ EL+ K + ++ K LE+++ DL EKL E
Sbjct: 1802 NEMK----ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1857
Query: 254 QRLEMVKGHHA-LALEANESIR--------------REYKIELEALKTKLDEEKQAIISK 298
QR+E +G ++ L + A++S R +E +++E +++ EK +I +
Sbjct: 1858 QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEK-CEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ +L+ + K+ K+K LE+ S + + +++ +L+ + + +
Sbjct: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD-------LKQE 410
++ E + +E++Q ++ H S+ IQ E E+KE L ++ S+ L+++
Sbjct: 1978 DQLSE-KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036
Query: 411 LNNLKNCKDELSTEKF---NFIEEIKTLKDELIEKTINY-----ENEKNKLNL--AVEKA 460
L +L+ LS K N I ++ K+ L++++ + E++ KLN+ A+E A
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 461 IKEKNKFETSLSVTRDIVHVL-----TLRLR-ESDSE-----LEQLEDQVQMLTSAKEVL 509
+ EK +F LS T++ VH L LR+R E+D + E+L+++ + S K+ +
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156
Query: 510 EN-ELTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRIMEHN-VTLIESLQNVE 566
EN E + N + D E +A V LK++ ++ E + VTL +N+
Sbjct: 2157 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2216
Query: 567 KEAYRELGTIK--NELIEDVE-LLKKESNSQIKFLRE 600
K+ + G + ++L+ + LL+++ ++I+ E
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Score = 68.1 bits (159), Expect = 1e-10
Identities = 87/379 (22%), Positives = 164/379 (43%), Gaps = 30/379 (7%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR 255
+++R+ LE E+ D Q + EE++ ++ + ++L + ++ +AET QR
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQC---EELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
+ ++ + A++++ E L AL+ K ++E Q + K + +Q A I+
Sbjct: 885 ISKLQEDTS----AHQNVVAE---TLSALENK-EKELQLLNDKVETEQ--------AEIQ 928
Query: 316 SLK--NQMLKEKCEALEQLHSQLIIKEQEMKAKLE----QIEESASEKLKICEIQFEERS 369
LK N +L++ + L+ L L ++++EM + + +IEE E + EI +
Sbjct: 929 ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEIN-ASLN 987
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
Q + E Y+++ K + D + L Q N ++LS +
Sbjct: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1047
Query: 430 EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD 489
E+ L+ L E T EN KN+L E KE +F T L+ + L L L
Sbjct: 1048 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ 1107
Query: 490 SEL-EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEY---KEALVNILKSKAALT 545
L ++ D S L+ E+ T K N +E ++ E L+ ++K+K
Sbjct: 1108 QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1167
Query: 546 KEHTRIMEHNVTLIESLQN 564
+ + ++V ES +N
Sbjct: 1168 NLESEPIRNSVKERESERN 1186
Score = 57.6 bits (133), Expect = 1e-07
Identities = 95/469 (20%), Positives = 205/469 (43%), Gaps = 23/469 (4%)
Query: 81 TKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
T A + + +TL+ +NK + EL D ++ + I E K ++ + +LQ +
Sbjct: 892 TSAHQNVVAETLSALENK---EKELQLLND-KVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ L+ + ++ + I N+ R++ +L N E NA + + + I
Sbjct: 948 SETLSLEKKEMSSIISLNK--REIEELTQENGTLK-EINASLNQEKMNLIQKSESFANYI 1004
Query: 201 IELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLC---KDLQEKLTSNELTLAETQQRL 256
E EK L ++ +K + L EE + L K QEK + E L E
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
E K EA +E+ +L +E Q ++ + + Q+ L+++ + +
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
K++ LK++ L++ +++ + ++ + EQ+ + K + ++ E S++E
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
S++ + + +++ + +LD N Q L+ L N + E EK E++T
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240
Query: 435 LKDELIEKTINYEN-EKNKLNLAVEKAIKEKNKFET---SLSVTRDIVHVLTLRLRESDS 490
++ +L +T N ++ + +++ + I + K+ + LS +++ L L+ + +
Sbjct: 1241 IRGDL--ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
+L +LE ++L + K L EL ++ R+ E L+N +K
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVK 1347
Score = 51.6 bits (118), Expect = 1e-05
Identities = 90/429 (20%), Positives = 187/429 (43%), Gaps = 49/429 (11%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQSI 372
E + N L+ K + E L +I++++ K + L +++E S KL + E+Q + ++
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS-KLHLQEVQLMTKIEA- 1824
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-----TEKFN 427
C + EK + L++E +L L+ + + +L Q + + +L + + +
Sbjct: 1825 ---CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1881
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL-R 486
+ + + D E+ ++ ENE +++ EKA E +L + D+ V T +L
Sbjct: 1882 IGDNVAKVNDSWKERFLDVENELSRIRS--EKASIEHE----ALYLEADLEVVQTEKLCL 1935
Query: 487 ESDSELEQ-----LEDQVQMLTSAKEVLENELTTY--KNT--------LNNTVRECDEYK 531
E D+E +Q LE+++ ++TS + L EL T K T + +E + ++
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
++ ++ A KE T +++ + + L + +L +++ + + + L K E
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCEL 2054
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXX 651
+QI L +E K+ ++ E V A AA + + E
Sbjct: 2055 ENQIAQLNKE--KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE--------FA 2104
Query: 652 XXXXSLVVELSLLRQENEELTMTVA----KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
S E+ LR+ E+L + + KQ I +KLK+ ++ L + L+
Sbjct: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2164
Query: 708 VGKENMQTI 716
+ +EN + +
Sbjct: 2165 MSEENQELV 2173
Score = 46.4 bits (105), Expect = 4e-04
Identities = 84/436 (19%), Positives = 177/436 (40%), Gaps = 24/436 (5%)
Query: 270 NESIRREYKIELEA--LKTKLDE--EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
NE + K+ L+ L TK++ E + I+ + K + +L K S +Q L ++
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK--LEYFSCDHQELLQR 1859
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKT 382
E E L+S L + K+ E I ++ + + K + E I+ + E
Sbjct: 1860 VETSEGLNSDLEMHAD--KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917
Query: 383 IQYLEQEIKEL---KYTLDLTNNQNSD----LKQELNNLKNCKDELSTEKFNFIEE---I 432
YLE +++ + K L+ N L++EL+ + + +++L E ++ +
Sbjct: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRESDSE 491
L +++ EKT E+ +++ ++ A E K K E +++ D+ +L + + +
Sbjct: 1978 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE-K 2036
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
L+ LE Q L+ K LEN++ V+E + + L K ++K
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 552 MEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
+ L + ++E ++ I+ +L +E +K+ + L+E + L +
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
+++ A + +E + ++L LR E E L
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215
Query: 672 TMTVAKQSSIIDKLKK 687
T + ++ + +L K
Sbjct: 2216 TKQIQEKQGQLSELDK 2231
Score = 40.7 bits (91), Expect = 0.018
Identities = 88/442 (19%), Positives = 187/442 (42%), Gaps = 51/442 (11%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQR 255
+I ELE + + L E +Q +L SLE + + ++ + + L L E +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
LE K + L+ ES + +L + K ++++ +Q + +CK + E + ++
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE-LKRCKSELERSQQAAQSADV 137
Query: 316 SLKNQMLKEKCEALEQLHSQLI--IKEQEMKAKL-EQIEESASEKLKICEIQFEERSQS- 371
SL +K SQ K +++K K +++EE + ++ +Q ++ SQ+
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 372 ---------IQEHCS-------QQEKTIQYLEQEIKELKYTLDLTNNQNS---DLKQELN 412
I H + QQEKT +L + D + + S ++ +
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 413 NLKNCKDELSTEKF------NFIEEIKTLKDELIEKTINYE--------------NEKNK 452
L+ K + ++ F + ++++K EL K E N+ +
Sbjct: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQE 317
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L L +EKA E + E L+ RD + T + ++ ++ LE +++ LT
Sbjct: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377
Query: 513 LTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQNVEKE 568
+ + +L ++E + E++E L +S L +E ++ + + +++ NV +
Sbjct: 378 AESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 569 AYRELGTIKNELIEDVELLKKE 590
+L ++K +L ++E K++
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQK 459
Score = 39.1 bits (87), Expect = 0.054
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 10/123 (8%)
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
+E L T+ I+ L+ Q+ K K E +Q QL E ++ + +++E +E +
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEK-QQRQFQLDSLEAALQKQKQKVENEKTEGTNL-- 65
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCK 418
+ +Q + E C EKT Q + E++ + ++ Q + K+++ LK CK
Sbjct: 66 ---KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 419 DEL 421
EL
Sbjct: 123 SEL 125
>AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 79.0 bits (186), Expect = 5e-14
Identities = 121/619 (19%), Positives = 256/619 (41%), Gaps = 31/619 (5%)
Query: 80 ITKAPNSSIK-KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
I A NS + +TL ++ ++ + V +R++ + + KQI++ + ++++L
Sbjct: 2174 ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL---TKQIQEKQGQLSELD 2230
Query: 139 EILKELATKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
++L + + I E + ++ N E A D E + A +
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
Query: 198 SRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
I E + ++ E ++E +++ ++ + L + E + +
Sbjct: 2291 PPIEEEHQLRNSI--EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIES 316
HA ALEA S K E+E LK K++ Q++ ++D +++ K N + E
Sbjct: 2349 RTNQEHA-ALEAENS-----KGEVETLKAKIEGMTQSLRG-LELDVVTIRSEKENLTNEL 2401
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
K Q E+ LE ++S QE + + Q++E +S +++ + Q +E ++ +
Sbjct: 2402 QKEQ---ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALH 2458
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
+ QE + EQ + L+L + + L Q L+ KN L + I+E++ K
Sbjct: 2459 NDQE-ACKAKEQNLSSQVECLEL---EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+L +K KN++ E+ + + ++ E + ++ L E + +++ L+
Sbjct: 2515 QKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+ L EVL++ +N L T + + E + + + L +E + +
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKES--NSQIK-----FLREEVEKKRVLC 609
L E L + EL + E+ + LK+ + NS++K +++VEK+ +
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQEN 668
E + LL ++ E+ S +E+ LL+
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 669 EELTMTVAKQSSIIDKLKK 687
EEL ++ + I+++LKK
Sbjct: 2754 EELNNSLKATTQILEELKK 2772
Score = 79.0 bits (186), Expect = 5e-14
Identities = 118/526 (22%), Positives = 240/526 (45%), Gaps = 52/526 (9%)
Query: 129 DYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG---TD 185
D K ++ LQ+ LKE ++ ++R+L R N + E +G T
Sbjct: 2313 DEKKQLCVLQQ-LKESEHHADLLKGRVE--NLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 186 AEKVSAMINDMRSR---IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL-QEK 241
K+ M +R ++ + + E L NE+ +Q +S LE + + +++ ++ QEK
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429
Query: 242 LTSNELTLAETQQRLEMVK--GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ E + + +K AL ++ + + L + L+ EK ++
Sbjct: 2430 VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGL 2489
Query: 300 KVDQEN---LKTKHNASIESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE--- 351
+ N L++ N I+ +++ Q L++K E + +L +Q+ +EQ + +KL Q+E
Sbjct: 2490 DEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-LVSKLSQVEGEH 2548
Query: 352 ---ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+ + +L+ ++ E++ Q +Q + + T++ L+ K L+ L+LT
Sbjct: 2549 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2608
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA---IKEKN 465
+++N + + EL E ++ L++EL + E L ++ + +KE
Sbjct: 2609 EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
Query: 466 KFETSLSVTRDIVHVLTL----RLRESDSE----LEQLEDQVQ-MLTSAKEVLENELTTY 516
+ L + D +H + ++RE +E L + E + Q +L + E E+ TY
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY 2728
Query: 517 KNTLNNTVRECDEYKEALVNILK-SKAALT---KEHTRIMEH-NVTLIESLQNV---EKE 568
+ L + EC ++ +++LK SK L K T+I+E T +++L+ V +KE
Sbjct: 2729 REKLTSK-EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2787
Query: 569 AYRELGTIK------NELIEDVELLKKESNSQIKFLREEVEKKRVL 608
R G +K +L E+ E+L+KE SQ++ +E+ + V+
Sbjct: 2788 NERAQGKMKLLIKSCKQLEEEKEILQKEL-SQLQAAQEKQKTGTVM 2832
Score = 75.4 bits (177), Expect = 7e-13
Identities = 87/335 (25%), Positives = 169/335 (50%), Gaps = 42/335 (12%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ L +++ + +L + Q++E+RN T+ E ++I+ +++ A LQ+ L+ L + +
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNL--TV-ELEQKIQVLQSKNASLQDTLEVLQSSY 2590
Query: 149 RQSHNNIDFNEIDR-----KLSKLRINNTNCHTE-HNAVQGTDA--EKVSAMINDMRSRI 200
+ N ++ ++D+ K++K+ T E H Q T E++S N + +
Sbjct: 2591 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGEL 2650
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL-EMV 259
L ++ ++ +++ + +E S L++ + D + KD EK +AE Q RL E
Sbjct: 2651 QLLLEEIKSSKDQLKELTLENSELKKSL---DCMHKDQVEKEGKVREEIAEYQLRLHEAE 2707
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
K H AL L+ N ++Y++E++ + KL +++ + S+ K++ + LK+ S E L N
Sbjct: 2708 KKHQALLLDTN----KQYEVEIQTYREKLTSKEECLSSQ-KLEIDLLKS----SKEELNN 2758
Query: 320 QMLKEKCEALEQLHSQLI--IKE-QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
LK + LE+L + +K ++K + E+ + +K C+ Q EE + +Q+
Sbjct: 2759 S-LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK-QLEEEKEILQKEL 2816
Query: 377 SQ----QEKT---------IQYLEQEIKELKYTLD 398
SQ QEK + L EIKELK TL+
Sbjct: 2817 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Score = 74.9 bits (176), Expect = 9e-13
Identities = 132/549 (24%), Positives = 230/549 (41%), Gaps = 55/549 (10%)
Query: 89 KKTL-TCPKN---KILPQDELVQAQDVEIRNKDQTICEYNKQIE--DYKNEIAQLQEILK 142
+KTL +C K+ K+L Q E + ++++ + C +QI+ +Y + L+ +
Sbjct: 615 EKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 673
Query: 143 ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRII 201
L+ + R HN +D ++ + KL E + + + E + + + ++
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE K + L NE+ DK L E ++RD L K L +NE +
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD-LLKSKDASLVTNEDHQRSLLAFDQQPA 792
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLK- 318
HH+ A E + E + + D+ K + I + +VD S+ES K
Sbjct: 793 MHHSFANIIGE--QGSMPSERSECRLEADQSPKNSAILQNRVDSLEF------SLESQKQ 844
Query: 319 -NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQS--IQ 373
N L+++CE L Q+ + I+E MKA EQ+ +S A +I ++Q + + +
Sbjct: 845 MNSDLQKQCEELVQIKGE--IEENLMKA--EQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 374 EHCS---QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
E S +EK +Q L +++ + + N L+ L L+ + LS EK
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 431 EIKTLKDELIE--------KTINYENEKNKLNLAVEKA------IKEKNKFETSLS-VTR 475
I K E+ E K IN + K+NL ++K+ I E+ K + LS +
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNL-IQKSESFANYIDEREKSISELSDQYK 1019
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+L R E+ + E L + + LE L + N E ++ KEA
Sbjct: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ + LTK E N L+ L+ V++ E+ +N + LK+E I
Sbjct: 1080 K--EHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE----I 1132
Query: 596 KFLREEVEK 604
L+EE K
Sbjct: 1133 MTLKEEQNK 1141
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/525 (22%), Positives = 231/525 (44%), Gaps = 60/525 (11%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE-----LATKFRQ 150
+NKI + +Q + E++ + E Q+E K E+ + +++L + + T +
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 151 SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
+ + +++KL KL TE + Q +AE S LE+K +
Sbjct: 351 DQASTKYTALEQKLKKL--------TEDLSCQRQNAE----------SARCSLEQKIKEK 392
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
+ E Q ELS + D C ++ +LT E QQ M H+ L E +
Sbjct: 393 EKEF---QEELSRQQRSFQTLDQECIQMKARLTQ------ELQQAKNM---HNVLQAELD 440
Query: 271 E--SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKC 326
+ S++++ + LE K KL +QA ++ + L+ S+E +K N +LK
Sbjct: 441 KLTSVKQQLENNLEEFKQKLCRAEQA-FQASQIKENELR----RSMEEMKKENNLLKSHS 495
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK--TIQ 384
E + L + + +K L Q ++ +E++K E + +QE +QQE T++
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQ-SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
Query: 385 YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-TEKFNFIEEIKTLKDELIEKT 443
L+ + +L+ D + + LK+ ++++ D+LS TEK E K L L K
Sbjct: 555 KLKLAVADLEKQRDCSQDL---LKKREHHIEQLNDKLSKTEK-----ESKALLSALELKK 606
Query: 444 INYENEKNKLNL-AVEKAIKEK--NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
YE K + L + K+ EK + E+ + ++ L L+ + + ++V+
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L +E L E+ N L++ E + K A + + + ++H + +E+
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
L ++ +L + NE++ D + ++ +++ + LR+ ++ K
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIM-DKDRCYQDLHAEYESLRDLLKSK 770
Score = 71.3 bits (167), Expect = 1e-11
Identities = 120/517 (23%), Positives = 242/517 (46%), Gaps = 62/517 (11%)
Query: 139 EILKELATKFRQSHNNIDF--NEIDRKLSKLRI---NNTNCHTEHNAVQGTDAEKVSAMI 193
E + EL+ + +DF N+ D +LR+ +N N H ++ D KV +++
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLH-VIEDRD-RKVESLL 1801
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
N+M+ EL+ K + ++ K LE+++ DL EKL E
Sbjct: 1802 NEMK----ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1857
Query: 254 QRLEMVKGHHA-LALEANESIR--------------REYKIELEALKTKLDEEKQAIISK 298
QR+E +G ++ L + A++S R +E +++E +++ EK +I +
Sbjct: 1858 QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEK-CEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ +L+ + K+ K+K LE+ S + + +++ +L+ + + +
Sbjct: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD-------LKQE 410
++ E + +E++Q ++ H S+ IQ E E+KE L ++ S+ L+++
Sbjct: 1978 DQLSE-KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036
Query: 411 LNNLKNCKDELSTEKF---NFIEEIKTLKDELIEKTINY-----ENEKNKLNL--AVEKA 460
L +L+ LS K N I ++ K+ L++++ + E++ KLN+ A+E A
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 461 IKEKNKFETSLSVTRDIVHVL-----TLRLR-ESDSE-----LEQLEDQVQMLTSAKEVL 509
+ EK +F LS T++ VH L LR+R E+D + E+L+++ + S K+ +
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156
Query: 510 EN-ELTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRIMEHN-VTLIESLQNVE 566
EN E + N + D E +A V LK++ ++ E + VTL +N+
Sbjct: 2157 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2216
Query: 567 KEAYRELGTIK--NELIEDVE-LLKKESNSQIKFLRE 600
K+ + G + ++L+ + LL+++ ++I+ E
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Score = 68.1 bits (159), Expect = 1e-10
Identities = 87/379 (22%), Positives = 164/379 (43%), Gaps = 30/379 (7%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR 255
+++R+ LE E+ D Q + EE++ ++ + ++L + ++ +AET QR
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQC---EELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
+ ++ + A++++ E L AL+ K ++E Q + K + +Q A I+
Sbjct: 885 ISKLQEDTS----AHQNVVAE---TLSALENK-EKELQLLNDKVETEQ--------AEIQ 928
Query: 316 SLK--NQMLKEKCEALEQLHSQLIIKEQEMKAKLE----QIEESASEKLKICEIQFEERS 369
LK N +L++ + L+ L L ++++EM + + +IEE E + EI +
Sbjct: 929 ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEIN-ASLN 987
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
Q + E Y+++ K + D + L Q N ++LS +
Sbjct: 988 QEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQ 1047
Query: 430 EEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD 489
E+ L+ L E T EN KN+L E KE +F T L+ + L L L
Sbjct: 1048 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ 1107
Query: 490 SEL-EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEY---KEALVNILKSKAALT 545
L ++ D S L+ E+ T K N +E ++ E L+ ++K+K
Sbjct: 1108 QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1167
Query: 546 KEHTRIMEHNVTLIESLQN 564
+ + ++V ES +N
Sbjct: 1168 NLESEPIRNSVKERESERN 1186
Score = 57.6 bits (133), Expect = 1e-07
Identities = 95/469 (20%), Positives = 205/469 (43%), Gaps = 23/469 (4%)
Query: 81 TKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
T A + + +TL+ +NK + EL D ++ + I E K ++ + +LQ +
Sbjct: 892 TSAHQNVVAETLSALENK---EKELQLLND-KVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ L+ + ++ + I N+ R++ +L N E NA + + + I
Sbjct: 948 SETLSLEKKEMSSIISLNK--REIEELTQENGTLK-EINASLNQEKMNLIQKSESFANYI 1004
Query: 201 IELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLC---KDLQEKLTSNELTLAETQQRL 256
E EK L ++ +K + L EE + L K QEK + E L E
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
E K EA +E+ +L +E Q ++ + + Q+ L+++ + +
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
K++ LK++ L++ +++ + ++ + EQ+ + K + ++ E S++E
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
S++ + + +++ + +LD N Q L+ L N + E EK E++T
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240
Query: 435 LKDELIEKTINYEN-EKNKLNLAVEKAIKEKNKFET---SLSVTRDIVHVLTLRLRESDS 490
++ +L +T N ++ + +++ + I + K+ + LS +++ L L+ + +
Sbjct: 1241 IRGDL--ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
+L +LE ++L + K L EL ++ R+ E L+N +K
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVK 1347
Score = 51.6 bits (118), Expect = 1e-05
Identities = 90/429 (20%), Positives = 187/429 (43%), Gaps = 49/429 (11%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQSI 372
E + N L+ K + E L +I++++ K + L +++E S KL + E+Q + ++
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS-KLHLQEVQLMTKIEA- 1824
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS-----TEKFN 427
C + EK + L++E +L L+ + + +L Q + + +L + + +
Sbjct: 1825 ---CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1881
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL-R 486
+ + + D E+ ++ ENE +++ EKA E +L + D+ V T +L
Sbjct: 1882 IGDNVAKVNDSWKERFLDVENELSRIRS--EKASIEHE----ALYLEADLEVVQTEKLCL 1935
Query: 487 ESDSELEQ-----LEDQVQMLTSAKEVLENELTTY--KNT--------LNNTVRECDEYK 531
E D+E +Q LE+++ ++TS + L EL T K T + +E + ++
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
++ ++ A KE T +++ + + L + +L +++ + + + L K E
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCEL 2054
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXX 651
+QI L +E K+ ++ E V A AA + + E
Sbjct: 2055 ENQIAQLNKE--KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE--------FA 2104
Query: 652 XXXXSLVVELSLLRQENEELTMTVA----KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
S E+ LR+ E+L + + KQ I +KLK+ ++ L + L+
Sbjct: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2164
Query: 708 VGKENMQTI 716
+ +EN + +
Sbjct: 2165 MSEENQELV 2173
Score = 46.4 bits (105), Expect = 4e-04
Identities = 84/436 (19%), Positives = 177/436 (40%), Gaps = 24/436 (5%)
Query: 270 NESIRREYKIELEA--LKTKLDE--EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
NE + K+ L+ L TK++ E + I+ + K + +L K S +Q L ++
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK--LEYFSCDHQELLQR 1859
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKT 382
E E L+S L + K+ E I ++ + + K + E I+ + E
Sbjct: 1860 VETSEGLNSDLEMHAD--KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917
Query: 383 IQYLEQEIKEL---KYTLDLTNNQNSD----LKQELNNLKNCKDELSTEKFNFIEE---I 432
YLE +++ + K L+ N L++EL+ + + +++L E ++ +
Sbjct: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRESDSE 491
L +++ EKT E+ +++ ++ A E K K E +++ D+ +L + + +
Sbjct: 1978 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE-K 2036
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
L+ LE Q L+ K LEN++ V+E + + L K ++K
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 552 MEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
+ L + ++E ++ I+ +L +E +K+ + L+E + L +
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
+++ A + +E + ++L LR E E L
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215
Query: 672 TMTVAKQSSIIDKLKK 687
T + ++ + +L K
Sbjct: 2216 TKQIQEKQGQLSELDK 2231
Score = 40.7 bits (91), Expect = 0.018
Identities = 88/442 (19%), Positives = 187/442 (42%), Gaps = 51/442 (11%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQR 255
+I ELE + + L E +Q +L SLE + + ++ + + L L E +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE 315
LE K + L+ ES + +L + K ++++ +Q + +CK + E + ++
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE-LKRCKSELERSQQAAQSADV 137
Query: 316 SLKNQMLKEKCEALEQLHSQLI--IKEQEMKAKL-EQIEESASEKLKICEIQFEERSQS- 371
SL +K SQ K +++K K +++EE + ++ +Q ++ SQ+
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 372 ---------IQEHCS-------QQEKTIQYLEQEIKELKYTLDLTNNQNS---DLKQELN 412
I H + QQEKT +L + D + + S ++ +
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 413 NLKNCKDELSTEKF------NFIEEIKTLKDELIEKTINYE--------------NEKNK 452
L+ K + ++ F + ++++K EL K E N+ +
Sbjct: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQE 317
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L L +EKA E + E L+ RD + T + ++ ++ LE +++ LT
Sbjct: 318 LQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377
Query: 513 LTTYKNTLNNTVRECD-EYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQNVEKE 568
+ + +L ++E + E++E L +S L +E ++ + + +++ NV +
Sbjct: 378 AESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 569 AYRELGTIKNELIEDVELLKKE 590
+L ++K +L ++E K++
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQK 459
Score = 39.1 bits (87), Expect = 0.054
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 10/123 (8%)
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE 362
+E L T+ I+ L+ Q+ K K E +Q QL E ++ + +++E +E +
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEK-QQRQFQLDSLEAALQKQKQKVENEKTEGTNL-- 65
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL----NNLKNCK 418
+ +Q + E C EKT Q + E++ + ++ Q + K+++ LK CK
Sbjct: 66 ---KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 419 DEL 421
EL
Sbjct: 123 SEL 125
>AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein
protein.
Length = 1843
Score = 79.0 bits (186), Expect = 5e-14
Identities = 132/621 (21%), Positives = 254/621 (40%), Gaps = 42/621 (6%)
Query: 85 NSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYK---NEIAQLQEIL 141
N +KKTL KN + L + E D+ E + +E K ++AQLQ
Sbjct: 672 NRKLKKTLDSFKNLTFQLESL----EKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 142 KELATKFRQSHNNIDFNEID-RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
KEL ++ Q ++ + +K +L ++ E+ +Q T E + I + S +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT-LENSNKKIQQLESEL 786
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LE + + L + + ++ LE++ SL ++ + L ++ L + +RL
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ-LEKDKKQLEKENKRLRQQA 845
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
LE N + E + L ++ K++ + ++++EN + A+I+
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 321 MLKEKCEALEQLHSQLIIKEQE-MKAKLEQIEESASEKLKICEIQFEERSQSIQEHC-SQ 378
L+E + E+L +Q + + E + +LE+I + L + + R + ++ S
Sbjct: 906 TLREDLVS-EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
Query: 379 QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE 438
+K+++ E++I L+ L+ + N N L+QEL +K N+ E +K +DE
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK----------NY-EALKQRQDE 1013
Query: 439 --LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+++ + E NK ++ +E K + L L + ++L+QLE
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1073
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
Q L + ++L + T NT + K + N + L + T +M N
Sbjct: 1074 TQNNNLQA--QILALQRQTVSLQEQNTTLQTQNAKLQVEN-----STLNSQSTSLMNQNA 1126
Query: 557 TLI---ESLQNVEKEAYRE---LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
L+ SL+N + +E L ++ + LI+D E L+ Q + K L
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS 1186
Query: 611 MXXXXXXXXXXXXXXSRVLLAQAA--ADLSR-LENENERYXXXXXXXXSLVVELSLLRQE 667
LL Q DL + L+ E E+ ++ E L E
Sbjct: 1187 AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1246
Query: 668 NEELTMTVAKQSSIIDKLKKD 688
N+ L T ++ + L+ D
Sbjct: 1247 NDRLNHTYSQLLKETEVLQTD 1267
Score = 72.9 bits (171), Expect = 4e-12
Identities = 132/669 (19%), Positives = 293/669 (43%), Gaps = 65/669 (9%)
Query: 73 ATPKAFKITKAPNSSIKKTLTCPKNKILPQDEL--VQAQDVEIRNKDQTICEYNKQIEDY 130
A K ++ + ++ L C + + EL +Q +++ + + ++ Y +++
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTD 185
+ + ++ ++ E++ ++++ ++I+F + ++ +L+ +N T E + ++GT
Sbjct: 316 REKAVRVDKLESEVS-RYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLE-DQLEGTR 371
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
A S ++++ ++L+ K ++ E D++ +EE +T+ + + + E L
Sbjct: 372 AR--SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 245 N-ELT-LAETQQRLEMVK---GHHALALEANESIRREYKIE-----LEALKTKLDEEKQA 294
EL ++ T + E + GH L ++ ++ E + + +E L+T +D +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEE 352
K+++EN + + +E L+N++++EK + + L L+ ++ +++ +E + E
Sbjct: 490 ASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 353 SASEKLKICEIQFE----------ERSQ-SIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ ++KI E + E +RSQ S + EK + L + IKE L
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+ +K+EL + K K E + E N + ++ + L +K N + K+ A+E+
Sbjct: 608 FEKRQIKKELEHYKE-KGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQEN 665
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL-EDQVQMLTSAKEVLENELTTYKNTL 520
E + L T D LT +L + E QL E+ +++ + + + + + L
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 521 NNTVRECDEYKEALVNILK-SKAALTKEHTRIMEHNVTLIES--LQNVEKEAYRELGTIK 577
N +E + KE L L+ KA+ K + + IE+ LQ + + +++ ++
Sbjct: 726 EN--KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 578 NELIEDVELLKKESNSQIKFLR------EEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLA 631
+EL +D+E+ + ++ L+ E++EK+ E L
Sbjct: 784 SEL-QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 632 QAA-----------ADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
Q A + LE EN+ V L L +EN+EL
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 681 IIDKLKKDL 689
+ L++DL
Sbjct: 903 TLVTLREDL 911
Score = 71.3 bits (167), Expect = 1e-11
Identities = 129/635 (20%), Positives = 272/635 (42%), Gaps = 68/635 (10%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ D K +I +L++ L+E + ++ EI+ L +L+ N N ++ + +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE--LKRLQQENMNLLSDARSARMYR 309
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
E ++ +R + + ++K L++EV + L +E K E+L +
Sbjct: 310 DE-----LDALREKAVRVDK----LESEVSRYKERLHDIE--------FYKARVEELKED 352
Query: 246 ELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQ 303
L ET+ LE ++G A + + +E + + LK KL D E + + + K+++
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEE 407
Query: 304 ENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
+ N ++E + Q + E LEQ+ + E K+ ++ E S +L
Sbjct: 408 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 361 CEIQFEERSQSIQEHCSQQEKT------IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E++ + +++++E + + I +E+E + L +++ N+ KQ L N
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+N +L EK + I+TL++ + E E LN V +++++++ V
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS-SLRQRSQISAEARV- 582
Query: 475 RDIVH---VLTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECD 528
+DI +L ++E+ S+L ++E + + + E + + +N L++ +E +
Sbjct: 583 KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE 642
Query: 529 EYKEALVNI---LKSKAALTKEHTRIMEHNVTLIESL----------QNVEKEAYRELGT 575
++ + N+ + AL +E++ + N L ++L +++EKE +L
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN-SQLDE 701
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAA 635
EL +VE LK S + E E + ++ R+ ++
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 636 DLSR------LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
D+ LEN N++ L +E L++ EEL ++ +K+ ++K K L
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL 820
Query: 690 EQ-SQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
EQ + K L K K ++ + E N
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Score = 59.3 bits (137), Expect = 5e-08
Identities = 122/570 (21%), Positives = 245/570 (42%), Gaps = 54/570 (9%)
Query: 70 LKFATPKAFKITKAPNSSIKKTLTCPKNKI-LPQDELVQAQDVEIRNKDQTICEYNKQIE 128
LK ++ + ++ K S ++T K+K L ++ Q EI KD T+ E N +I
Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KDTTLEENNVKIG 860
Query: 129 DYKNEIAQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
+ + E L + I KE + ++ N+ K + + I T + V ++
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKE---NKELVKRATIDIK-TLVTLREDLV--SE 914
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
K M ND+ ELEK + ++D+Q S +++ L L++ L
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL--ESKLESTLKKSLEIK 972
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
E +A + RLE ++ + +++++ Y EALK + DEE+ + S + E+
Sbjct: 973 EEKIAALEARLEESTNYNQQLRQELKTVKKNY----EALKQRQDEERM-VQSSPPISGED 1027
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE-ESASEKLKICEIQ 364
K + + + + +K++ +E+ ++ L ++Q +K +L+Q+E ++ + + +I +Q
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 365 -----FEERSQSIQ--------EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQEL 411
+E++ ++Q E+ + ++ + Q + L L N S +K E
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK-ER 1146
Query: 412 NNLKNCKDEL--STEKFNFIEEIKTLKDE-LIEK--TI-----NYENEKNKLNLAVEKAI 461
+LK+ D L EK + E + + E LI K T+ N E E L + +
Sbjct: 1147 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1206
Query: 462 KEKNKFET---SLSVTRDIV-------HVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
K+K + E L V ++ + + ++ E ++L L EVL+
Sbjct: 1207 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1266
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
+ K+ LNN+ E + + + L T++ L + N+E+E
Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREE 601
L I+ ++++ LL++ S+ F E+
Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQ 1356
Score = 53.6 bits (123), Expect = 2e-06
Identities = 82/419 (19%), Positives = 185/419 (44%), Gaps = 37/419 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQ---DVEIRNKDQTI---CEYNKQIEDYKNEIAQLQE 139
S++KK+L + KI + ++ + ++R + +T+ E KQ +D + +
Sbjct: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
Query: 140 ILKELATKFRQSHNNI-DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
I E R+S + ++ +L ++ NN E A++ T +++ N++++
Sbjct: 1023 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK-TQLKQLETQNNNLQA 1081
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I+ L+++ +L + Q + + L+ + +S L + + + + E
Sbjct: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK---CKVDQENLKTKHNASIE 315
V +S+ ++++ +LE L + E +++ISK K +NL+ +H +E
Sbjct: 1142 VIKEREDLKSLYDSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-DLE 1199
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE------------- 362
NQ+LK+K + LE L L +++++M + + E A+E K+C
Sbjct: 1200 DRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1258
Query: 363 -----IQFEERSQSIQEHCSQQEKT-----IQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+Q + ++ + S+ E+T L+++ ++L T NNQ L Q
Sbjct: 1259 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318
Query: 413 NLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
NL+ L + + + +TL ++ +E + E+ + + + ++K K E +
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
Score = 50.8 bits (116), Expect = 2e-05
Identities = 97/404 (24%), Positives = 174/404 (43%), Gaps = 46/404 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V+ + ++ + Q + KQ+E N + Q Q + + T Q N + + +
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNL-QAQILALQRQTVSLQEQNTT----LQTQNA 1105
Query: 166 KLRINNTNCHTEHNAVQGTDAEKV---SAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
KL++ N+ +++ ++ +A+ + S++ N+ S I E E D+ + D + +L
Sbjct: 1106 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KLE 1164
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E R + E L S TL + LE+ H L N+ ++++ ++E
Sbjct: 1165 LLHE----RQA---SEYESLISKHGTLKSAHKNLEVE--HRDLEDRYNQLLKQKGQLEDL 1215
Query: 283 ALKTKLDEEKQAIISKCK--VDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
K+++EK + +K V E K N + +Q+LKE E L+ H L K
Sbjct: 1216 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNL--K 1272
Query: 340 EQEMKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+KLEQ E+ KLK Q + S + C + LE+E + L +
Sbjct: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1332
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTIN----YE---- 447
QN L ++ N+++ KD E+ +I+ E++ K++L EK ++ Y+
Sbjct: 1333 TLMLQNRTLLEQ--NMES-KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPP 1389
Query: 448 -NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
N + L + K IK K + R+ LTL SDS
Sbjct: 1390 RRRGNWITLKMRKLIKSKK------DINRERQKSLTLTPTRSDS 1427
>AB035898-1|BAB03309.1| 1388|Homo sapiens kinesin-like protein 2
protein.
Length = 1388
Score = 79.0 bits (186), Expect = 5e-14
Identities = 102/434 (23%), Positives = 194/434 (44%), Gaps = 35/434 (8%)
Query: 122 EYNKQ-IEDYKNEIAQLQEILKELATKF-RQSHNNIDFNEIDRKLSKLRINNTNCHTEHN 179
E N+Q E E+ +QE + L K + H N+ + KL +
Sbjct: 706 EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSER 765
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVIT---VRDSLCK 236
E++ + +N + ++ E + K + L +EV+D ++ L S ++ ++ + S K
Sbjct: 766 IDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFK 825
Query: 237 DLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQA 294
QEK N+L+ Q +L+ ++ + LE+ ++ Y E +K ++D+ +
Sbjct: 826 TNQEK-EFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRN 884
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESA 354
+ +N K K N +++S N ++ E EA ++ +++L ++ +E K E S+
Sbjct: 885 L--------QNFK-KENETLKSDLNNLM-ELLEAEKERNNKLSLQFEEDK------ENSS 928
Query: 355 SEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD-LTNNQNSDLKQELNN 413
E LK+ E +E+ + + C QQ +Q LE+ + + + L +++SD K+ + +
Sbjct: 929 KEILKVLEAVRQEKQKETAK-CEQQMAKVQKLEESLLATEKVISSLEKSRDSD-KKVVAD 986
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L N EL T E I TLK EL K IN + ++ + + +K + +
Sbjct: 987 LMNQIQELRTSVCEKTETIDTLKQEL--KDINCKYNSALVDREESRVLIKKQEVD----- 1039
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
D+ L LR+ D E + L + + T +L + L + E + KEA
Sbjct: 1040 ILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTK-KEA 1098
Query: 534 LVNILKSKAALTKE 547
L+ L+ K KE
Sbjct: 1099 LIQELQHKLNQKKE 1112
Score = 63.3 bits (147), Expect = 3e-09
Identities = 130/624 (20%), Positives = 253/624 (40%), Gaps = 47/624 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYK-NEIAQLQEILKELATKFRQSHNNIDFNEID 161
+++ Q +D+ + K + + NK I ++ ++I +L+++ KE F + +E+
Sbjct: 437 EKVTQLEDLTL--KKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELR 494
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
++ LR + H V E S + R R++E K+ + +D + K +
Sbjct: 495 NEIQTLREQIEH----HPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKA 550
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S + D + K A T+ +L+ L ++ E+K
Sbjct: 551 FSEISGMEKSDKNQQGFSPKAQKEPCLFANTE-KLKAQLLQIQTELNNSKQEYEEFKELT 609
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE---------QL 332
+ +L+ E Q++ K ++ ENL A +Q+ K E L+ QL
Sbjct: 610 RKRQLELESELQSL-QKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQL 668
Query: 333 HSQLIIK---EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
HS+ + K E L S + + E E ++ E S++ +T+Q ++
Sbjct: 669 HSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQ---EQ 725
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
+ L+ LD ++N L+Q ++ L++ ++ E F+ E I+ T E
Sbjct: 726 MSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQ-ELFS---------SERIDWTKQQEEL 775
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
++LN+ +EK ++E +T + VH L + L +D EL ++ + +S K
Sbjct: 776 LSQLNV-LEKQLQET---QTKNDFLKSEVHDLRVVLHSADKELSSVKLEY---SSFKTNQ 828
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
E E + + D + +L+SKA L + + E I+ L +
Sbjct: 829 EKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNF 888
Query: 570 YRELGTIKNELIEDVELL--KKESNSQIKFLREEVEK---KRVLCEMXXXXXXXXXXXXX 624
+E T+K++L +ELL +KE N+++ EE ++ K +L +
Sbjct: 889 KKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAK 948
Query: 625 XSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDK 684
+ + + S L E V L+ Q +EL +V +++ ID
Sbjct: 949 CEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQ-IQELRTSVCEKTETIDT 1007
Query: 685 LKKDLEQSQYTPKSPSVLRKSLKV 708
LK++L+ S V R+ +V
Sbjct: 1008 LKQELKDINCKYNSALVDREESRV 1031
Score = 58.4 bits (135), Expect = 8e-08
Identities = 108/536 (20%), Positives = 231/536 (43%), Gaps = 40/536 (7%)
Query: 76 KAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIED-YKNEI 134
K K SS K NK+ + VQ Q +R +++ + E ++D Y N
Sbjct: 812 KELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDN-- 869
Query: 135 AQLQEILK-ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
LQEI+K E+ R N NE + + E N E+
Sbjct: 870 --LQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENS 927
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQM-ELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +++E ++ + + ++QM ++ LEE + + + L++ S++ +A+
Sbjct: 928 SKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADL 987
Query: 253 QQRLEMVKGHHALALEANESIRREYK-IELEALKTKLD-EEKQAIISKCKVDQENLKTKH 310
+++ ++ E +++++E K I + +D EE + +I K +VD +LK
Sbjct: 988 MNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLK--- 1044
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
E+L+ ++L E E + L L +++ E AS+K Q
Sbjct: 1045 ----ETLRLRILSEDIER-DMLCEDLAHATEQLNMLTE-----ASKK-------HSGLLQ 1087
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
S QE +++E IQ L+ ++ + K ++ N+ + ++L ++ + E +
Sbjct: 1088 SAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAE-DPQSPKTPP 1146
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
+T +L+E T E E + A + +++ T L+ R++ + LR++E
Sbjct: 1147 HFQTHLAKLLE-TQEQEIEDGR---ASKTSLEH---LVTKLNEDREVKNAEILRMKEQLR 1199
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E+E L + Q L +L+ +L K N+ + + + L N + ++
Sbjct: 1200 EMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPD-NQQLKNEQEESIKERLAKSK 1258
Query: 551 IMEHNVTLIESLQNVEKEAY-RELGTIK-NELIEDVELLKKESNSQIKFLREEVEK 604
I+E + + L+ V+ Y +E+ ++ + +E + L+ ++ + + LR ++E+
Sbjct: 1259 IVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEE 1314
Score = 48.8 bits (111), Expect = 7e-05
Identities = 93/470 (19%), Positives = 185/470 (39%), Gaps = 52/470 (11%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ +L ++++ + + + + + + QI++ + + + E + L + + +
Sbjct: 960 EESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKY 1019
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ +DR+ S++ I Q D + + +R RI+ + + + L ++
Sbjct: 1020 NSALVDREESRVLIKK----------QEVD---ILDLKETLRLRILSEDIERDMLCEDLA 1066
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+L+ L E L + QE+LT E + E Q +L K E E +
Sbjct: 1067 HATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKK-------EEVEQKKN 1119
Query: 276 EYKIELEALKTKLD---EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL-EQ 331
EY ++ L+ +D E+ Q+ + K E + K E L +
Sbjct: 1120 EYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTK 1179
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
L+ +K E+ EQ+ E E L++ Q E++ +Q +IK
Sbjct: 1180 LNEDREVKNAEILRMKEQLRE--MENLRLESQQLIEKNWLLQGQL-----------DDIK 1226
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE-KTINYENEK 450
K D + N LK E ++ K+ L+ K +EE+ +K +L E ++ Y E
Sbjct: 1227 RQKENSDQNHPDNQQLKNEQE--ESIKERLAKSK--IVEEMLKMKADLEEVQSALYNKEM 1282
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
L + E ++ E+ ++ L +L E E E+ +++ML E L
Sbjct: 1283 ECLRMTDE--VERTQTLESKAFQEKE---QLRSKLEEMYEERERTSQEMEMLRKQVECLA 1337
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
E K + + + +Y +V + K L +E ++ NV L E
Sbjct: 1338 EE--NGKLVGHQNLHQKIQY---VVRLKKENVRLAEETEKLRAENVFLKE 1382
>BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein.
Length = 887
Score = 78.6 bits (185), Expect = 7e-14
Identities = 114/503 (22%), Positives = 216/503 (42%), Gaps = 43/503 (8%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIA-QLQEILK--ELATKFRQSHNNIDFNEI-DRKLSKL 167
E+ ++ T+ KQ D + +L++I + EL+ ++S + + NE+ +L KL
Sbjct: 404 ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKL 462
Query: 168 RINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+ N + ++ T E ++ I M L KK E L+NE+ E SL+
Sbjct: 463 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ---EKQSLQ 519
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L K+ + + E +++++++++ + + S+R+ +I EA
Sbjct: 520 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARV 579
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQL--IIKEQ 341
+++E + + K L +K +K ++ KEK E E+L ++L + KE
Sbjct: 580 KDIEKENKILHESIKETSSKL-SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 638
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
E+ K + EK++ E +E S+ +E+ + +KT+ K L + L+
Sbjct: 639 ELLQKKITNLKITCEKIEALE---QENSELEREN-RKLKKTLD----SFKNLTFQLESLE 690
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA- 460
+NS L +E L+ + L +K + +L K + E E+ K L + KA
Sbjct: 691 KENSQLDEENLELRRNVESLKCAS------MKMAQLQLENKELESEKEQLKKGLELLKAS 744
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK--- 517
K+ + E S L L S+ +++QLE ++Q L + L+ L K
Sbjct: 745 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 804
Query: 518 NTLNNTVRECDEYKEALVNILKSKAALTKEHTRI----------MEHNVTLIESLQNVEK 567
L +E ++ + K K L KE+ R+ +E N I +L+ K
Sbjct: 805 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 864
Query: 568 EAYRELGTIKNELIEDVELLKKE 590
+E+G K + EL KK+
Sbjct: 865 TLSKEIGIYKESCVRLKELKKKK 887
Score = 72.9 bits (171), Expect = 4e-12
Identities = 112/538 (20%), Positives = 228/538 (42%), Gaps = 58/538 (10%)
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LEMVKGHHALALE 268
L E+ D + ++ L + + + D +++L E+ L QQ + ++ + +
Sbjct: 246 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 305
Query: 269 ANE-SIRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEK 325
+E RE + ++ L++++ K+ + I K E LK + +E+ ML+++
Sbjct: 306 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET--KTMLEDQ 363
Query: 326 CEALEQLHSQLIIKEQE---MKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEK 381
E +L E+E +KAKL +E E ++ KI E+ E + + + S E
Sbjct: 364 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 423
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC---KDELSTEKFN-FIEEIKTLKD 437
+L E++++ T +L+ L E+N L + K E+ + +EE++T D
Sbjct: 424 L--HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 481
Query: 438 EL---IEKTINYENEKNKLNLAVE----KAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
+ K + E E +L+ VE + ++EK + ++++D++ + ++
Sbjct: 482 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 541
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E Q++ +LE E T+++ + EA V ++ + + E +
Sbjct: 542 LRENSERQIK-------ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 594
Query: 551 IMEHNVTLIE-SLQNVEKEA--YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
++ IE + ++KE Y+E G EL ++ L+KE+ + L++++ ++
Sbjct: 595 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN----ELLQKKITNLKI 650
Query: 608 LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQE 667
CE L Q + S LE EN + +L +L L +E
Sbjct: 651 TCEKIEA---------------LEQ---ENSELERENRKLKKTLDSFKNLTFQLESLEKE 692
Query: 668 NEELTMTVAKQSSIIDKLK---KDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRER 722
N +L + ++ LK + Q Q K ++ LK G E ++ ER
Sbjct: 693 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 750
Score = 71.3 bits (167), Expect = 1e-11
Identities = 129/635 (20%), Positives = 272/635 (42%), Gaps = 68/635 (10%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ D K +I +L++ L+E + ++ EI+ L +L+ N N ++ + +
Sbjct: 249 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE--LKRLQQENMNLLSDARSARMYR 306
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
E ++ +R + + ++K L++EV + L +E K E+L +
Sbjct: 307 DE-----LDALREKAVRVDK----LESEVSRYKERLHDIE--------FYKARVEELKED 349
Query: 246 ELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQ 303
L ET+ LE ++G A + + +E + + LK KL D E + + + K+++
Sbjct: 350 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEE 404
Query: 304 ENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
+ N ++E + Q + E LEQ+ + E K+ ++ E S +L
Sbjct: 405 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 461
Query: 361 CEIQFEERSQSIQEHCSQQEKT------IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E++ + +++++E + + I +E+E + L +++ N+ KQ L N
Sbjct: 462 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 521
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+N +L EK + I+TL++ + E E LN V +++++++ V
Sbjct: 522 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS-SLRQRSQISAEARV- 579
Query: 475 RDIVH---VLTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECD 528
+DI +L ++E+ S+L ++E + + + E + + +N L++ +E +
Sbjct: 580 KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE 639
Query: 529 EYKEALVNI---LKSKAALTKEHTRIMEHNVTLIESL----------QNVEKEAYRELGT 575
++ + N+ + AL +E++ + N L ++L +++EKE +L
Sbjct: 640 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN-SQLDE 698
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAA 635
EL +VE LK S + E E + ++ R+ ++
Sbjct: 699 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 758
Query: 636 DLSR------LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
D+ LEN N++ L +E L++ EEL ++ +K+ ++K K L
Sbjct: 759 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL 817
Query: 690 EQ-SQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
EQ + K L K K ++ + E N
Sbjct: 818 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 852
Score = 69.7 bits (163), Expect = 3e-11
Identities = 130/656 (19%), Positives = 297/656 (45%), Gaps = 64/656 (9%)
Query: 73 ATPKAFKITKAPNSSIKKTLTCPKNKILPQDEL--VQAQDVEIRNKDQTICEYNKQIEDY 130
A K ++ + ++ L C + + EL +Q +++ + + ++ Y +++
Sbjct: 253 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 312
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTD 185
+ + ++ ++ E++ ++++ ++I+F + ++ +L+ +N T E + ++GT
Sbjct: 313 REKAVRVDKLESEVS-RYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLE-DQLEGTR 368
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
A S ++++ ++L+ K ++ E D++ +EE +T+ + + + E L
Sbjct: 369 AR--SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 426
Query: 245 N-ELT-LAETQQRLEMVK---GHHALALEANESIRREYKIE-----LEALKTKLDEEKQA 294
EL ++ T + E + GH L ++ ++ E + + +E L+T +D +
Sbjct: 427 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 486
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEE 352
K+++EN + + +E L+N++++EK + + L L+ ++ +++ +E + E
Sbjct: 487 ASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 544
Query: 353 SASEKLKICEIQFE----------ERSQ-SIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ ++KI E + E +RSQ S + EK + L + IKE L
Sbjct: 545 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 604
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+ +K+EL + K K E + E N + ++ + L +K N + K+ A+E+
Sbjct: 605 FEKRQIKKELEHYKE-KGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQEN 662
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL-EDQVQMLTSAKEVLENELTTYKNTL 520
E + L T D LT +L + E QL E+ +++ + + + + + L
Sbjct: 663 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 722
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK--N 578
N +E + KE L L+ A K+ R L S Q ++ E R T++ N
Sbjct: 723 EN--KELESEKEQLKKGLELLKASFKKTER-------LEVSYQGLDIENQRLQKTLENSN 773
Query: 579 ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
+ I+ +E ++ + + L++ +E+ ++ + + +Q D
Sbjct: 774 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET----SQLEKDKK 829
Query: 639 RLENENERYXXXXXXXXSLV----VELSLLRQENEELTMTVA--KQSSI-IDKLKK 687
+LE EN+R + + V++ L +EN+ L+ + K+S + + +LKK
Sbjct: 830 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELKK 885
>AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1044
Score = 78.6 bits (185), Expect = 7e-14
Identities = 132/640 (20%), Positives = 269/640 (42%), Gaps = 37/640 (5%)
Query: 82 KAPNSSIKKTLTCPKNKI-LPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
+A NS +K + ++ L Q+EL++ + N + E K+ QL+E
Sbjct: 281 EAENSDLKVNMAHRTSQFQLIQEELLE----KASNSSKLESEMTKKCSQLLTLEKQLEE- 335
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
K +A + N E+ K K+R TN +TEH + EK + +
Sbjct: 336 -KIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC-LAFEKAKKIHLEQHK-- 391
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITV--RDSLCKDLQEKLTSNELTLAETQQRLEM 258
E+EK+ E L+ ++ K + E+ +++ +D +CK Q L S + L E++ ++
Sbjct: 392 -EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK--QHHLESLDRLLTESKGEMKK 448
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
AL+A ++ E I++ L + L+ K+ ++ + N E +
Sbjct: 449 ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK--------EKFE 500
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ---IEESASEKLKICEIQFEERSQSIQEH 375
Q LK+K E + L +L IK ++ EQ ++ + ++ ++ + Q R+ +++
Sbjct: 501 KQ-LKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQ-QETIRNGELEDT 558
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTL 435
++ EK + LEQE+++ + + + + + + + K + E ++K
Sbjct: 559 QTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIE 618
Query: 436 KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL 495
D+ E+ E E L E ++ + L T+ + T ++E +
Sbjct: 619 MDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHST 678
Query: 496 EDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
E ++ +EVLE EL L +T+R+ E ++ L K++ +L +++T I +
Sbjct: 679 ETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL---QKAQLSLEEKYTTIKDLT 735
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXX 615
L E +E + +EL + L E LK+ + +Q+ L + + R E
Sbjct: 736 AELRECKMEIE-DKKQELLEMDQALKERNWELKQRA-AQVTHLDMTIREHRGEMEQKIIK 793
Query: 616 XXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
+ L+ +L+N E+ E+S L++E E
Sbjct: 794 LEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 853
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
+ + S++ K ++ +QY K L + L++ +E +Q
Sbjct: 854 MKEMESVM-KEQEQYIATQY--KEAIDLGQELRLTREQVQ 890
Score = 70.1 bits (164), Expect = 3e-11
Identities = 155/694 (22%), Positives = 296/694 (42%), Gaps = 101/694 (14%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEY-NKQIED----YKNEIAQLQEILKELATKFRQ 150
K K+ + E VQA++ EI ++ T CE NK++++ YK+E+ EILKE + ++
Sbjct: 1 KKKVAEKLEKVQAEE-EILERNLTNCEKENKRLQERCGLYKSEL----EILKEKLRQLKE 55
Query: 151 SHNN---------IDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM--INDMRSR 199
+NN + +E+ +L++ R + +E +K S M +++ R
Sbjct: 56 ENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVR 115
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+ ++ + E+ ++EL SLE++I+ L+ +L + L++ Q
Sbjct: 116 VAAQNERLDLCQQEIESSRVELRSLEKIISQ-----LPLKRELFGFKSYLSKYQMSSFSN 170
Query: 260 KGHHAL-ALEANESIRREYKIEL---EALKTKL------DEEKQAIISKCKVDQEN---- 305
K + EAN+ + E +I+L EA KL ++ Q++I+ C QE+
Sbjct: 171 KEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT-CNDSQESSKLS 229
Query: 306 ------LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK 359
+K + ES+K+Q + E+ +L+ +E++ KL QIE S+ LK
Sbjct: 230 SLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSD-LK 288
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEI-KELKYTLDLTNN-------------QNS 405
+ + Q IQE ++ LE E+ K+ L L +N+
Sbjct: 289 VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNA 348
Query: 406 DLKQEL----NNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+L+QEL +++ + ++TE + K +E+ E + +L +EK
Sbjct: 349 ELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKD 408
Query: 462 KEKNKFETSLS-VTRDIV----HVLTL--RLRES-----------DSELEQLEDQ----- 498
++ + E ++S + +DI+ H+ +L L ES D L+ L++Q
Sbjct: 409 QQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEET 468
Query: 499 --VQMLTSAKEVLENELTTYKNTLNNTVRECDEY--KEALVNILKSKAALTKEHT--RIM 552
V+ L SA E+ + EL + N L + ++ K++ K K H+
Sbjct: 469 IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETS 528
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX 612
E NV L +LQ ++ +E TI+N +ED + + Q+ L +E++K+R
Sbjct: 529 EQNVILQHTLQQQQQMLQQE--TIRNGELEDTQ---TKLEKQVSKLEQELQKQRESSAEK 583
Query: 613 XXXXXXXXXXXXXSRVLLAQAAADLSRLENENE-RYXXXXXXXXSLVVELSLLRQENEEL 671
L Q +L+ + + + E+ L+++ E
Sbjct: 584 LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENK 643
Query: 672 TMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
M +++ I+D+ K +LE+ K L+ S
Sbjct: 644 AMHLSQLDMILDQTKTELEKKTNAVKELEKLQHS 677
Score = 42.3 bits (95), Expect = 0.006
Identities = 66/359 (18%), Positives = 153/359 (42%), Gaps = 26/359 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKL 167
+ E++N + +Q+++ ++ + + Q L+E T + + EI+ K +L
Sbjct: 693 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 752
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
+ E N A +V+ + +R E+E+K L+ + ++EL +
Sbjct: 753 -LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQ 811
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK 287
I + ++ +E+L E + + +Q + +K + + + K + + + T+
Sbjct: 812 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ 871
Query: 288 LDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
+E + + ++ +E ++ H E+ Q+ ++ +E+L S+L +Q K K
Sbjct: 872 Y-KEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQR--EIERLSSELEDMKQLSKEKD 928
Query: 348 EQIEESASE--KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK--YTLDLTNNQ 403
A E K+ E E R Q+ I+ L E++ LK Y +++ ++Q
Sbjct: 929 AHGNHLAEELGASKVREAHLEARMQA----------EIKKLSAEVESLKEAYHMEMISHQ 978
Query: 404 NSDLKQEL--NNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ K ++ ++ K+ +L+ + +E+ K +E + N + N +E A
Sbjct: 979 ENHAKWKISADSQKSSVQQLNEQ----LEKAKLELEEAQDTVSNLHQQVQDRNEVIEAA 1033
Score = 37.9 bits (84), Expect = 0.13
Identities = 41/207 (19%), Positives = 106/207 (51%), Gaps = 26/207 (12%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE----LATKFRQSHNNIDF 157
+++L + + + ++N +Q I + K+IE + + +++ ++KE +AT+++++ ID
Sbjct: 823 KEQLREKEFIMLQN-EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEA---IDL 878
Query: 158 NEIDRKLSKLRINNTN---CHTEHNAVQG-TDAEKVSAMINDMRSRIIELEKKCEALDNE 213
+ + +L++ ++ N++ H VQ + E++S+ + DM+ +L K+ +A N
Sbjct: 879 GQ-ELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMK----QLSKEKDAHGNH 933
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV--KGHHA---LALE 268
+ ++ E + R + K S E+ + +EM+ + +HA ++ +
Sbjct: 934 LAEELGASKVREAHLEAR----MQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISAD 989
Query: 269 ANESIRREYKIELEALKTKLDEEKQAI 295
+ +S ++ +LE K +L+E + +
Sbjct: 990 SQKSSVQQLNEQLEKAKLELEEAQDTV 1016
>AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1454
Score = 78.6 bits (185), Expect = 7e-14
Identities = 132/640 (20%), Positives = 269/640 (42%), Gaps = 37/640 (5%)
Query: 82 KAPNSSIKKTLTCPKNKI-LPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEI 140
+A NS +K + ++ L Q+EL++ + N + E K+ QL+E
Sbjct: 535 EAENSDLKVNMAHRTSQFQLIQEELLE----KASNSSKLESEMTKKCSQLLTLEKQLEE- 589
Query: 141 LKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
K +A + N E+ K K+R TN +TEH + EK + +
Sbjct: 590 -KIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC-LAFEKAKKIHLEQHK-- 645
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITV--RDSLCKDLQEKLTSNELTLAETQQRLEM 258
E+EK+ E L+ ++ K + E+ +++ +D +CK Q L S + L E++ ++
Sbjct: 646 -EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK--QHHLESLDRLLTESKGEMKK 702
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
AL+A ++ E I++ L + L+ K+ ++ + N E +
Sbjct: 703 ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK--------EKFE 754
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ---IEESASEKLKICEIQFEERSQSIQEH 375
Q LK+K E + L +L IK ++ EQ ++ + ++ ++ + Q R+ +++
Sbjct: 755 KQ-LKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQ-QETIRNGELEDT 812
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTL 435
++ EK + LEQE+++ + + + + + + + K + E ++K
Sbjct: 813 QTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIE 872
Query: 436 KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL 495
D+ E+ E E L E ++ + L T+ + T ++E +
Sbjct: 873 MDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHST 932
Query: 496 EDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
E ++ +EVLE EL L +T+R+ E ++ L K++ +L +++T I +
Sbjct: 933 ETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL---QKAQLSLEEKYTTIKDLT 989
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXX 615
L E +E + +EL + L E LK+ + +Q+ L + + R E
Sbjct: 990 AELRECKMEIE-DKKQELLEMDQALKERNWELKQRA-AQVTHLDMTIREHRGEMEQKIIK 1047
Query: 616 XXXXXXXXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
+ L+ +L+N E+ E+S L++E E
Sbjct: 1048 LEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 1107
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
+ + S++ K ++ +QY K L + L++ +E +Q
Sbjct: 1108 MKEMESVM-KEQEQYIATQY--KEAIDLGQELRLTREQVQ 1144
Score = 72.5 bits (170), Expect = 5e-12
Identities = 155/693 (22%), Positives = 295/693 (42%), Gaps = 100/693 (14%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEY-NKQIED----YKNEIAQLQEILKELATKFRQ 150
K K+ + E VQA++ EI ++ T CE NK++++ YK+E+ EILKE + ++
Sbjct: 256 KKKVAEKLEKVQAEE-EILERNLTNCEKENKRLQERCGLYKSEL----EILKEKLRQLKE 310
Query: 151 SHNN---------IDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM--INDMRSR 199
+NN + +E+ +L++ R + +E +K S M +++ R
Sbjct: 311 ENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVR 370
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+ ++ + E+ ++EL SLE++I+ L+ +L + L++ Q
Sbjct: 371 VAAQNERLDLCQQEIESSRVELRSLEKIISQ-----LPLKRELFGFKSYLSKYQMSSFSN 425
Query: 260 KGHHAL-ALEANESIRREYKIEL---EALKTKL------DEEKQAIISKCKVDQENLKTK 309
K + EAN+ + E +I+L EA KL ++ Q++I+ C QE+ K
Sbjct: 426 KEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT-CNDSQESSKLS 484
Query: 310 H---------NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
+ES+K+Q + E+ +L+ +E++ KL QIE S+ LK+
Sbjct: 485 SLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSD-LKV 543
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEI-KELKYTLDLTNN-------------QNSD 406
+ Q IQE ++ LE E+ K+ L L +N++
Sbjct: 544 NMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAE 603
Query: 407 LKQEL----NNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L+QEL +++ + ++TE + K +E+ E + +L +EK +
Sbjct: 604 LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQ 663
Query: 463 EKNKFETSLS-VTRDIV----HVLTL--RLRES-----------DSELEQLEDQ------ 498
+ + E ++S + +DI+ H+ +L L ES D L+ L++Q
Sbjct: 664 QFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETI 723
Query: 499 -VQMLTSAKEVLENELTTYKNTLNNTVRECDEY--KEALVNILKSKAALTKEHT--RIME 553
V+ L SA E+ + EL + N L + ++ K++ K K H+ E
Sbjct: 724 KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 783
Query: 554 HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXX 613
NV L +LQ ++ +E TI+N +ED + + Q+ L +E++K+R
Sbjct: 784 QNVILQHTLQQQQQMLQQE--TIRNGELEDTQ---TKLEKQVSKLEQELQKQRESSAEKL 838
Query: 614 XXXXXXXXXXXXSRVLLAQAAADLSRLENENE-RYXXXXXXXXSLVVELSLLRQENEELT 672
L Q +L+ + + + E+ L+++ E
Sbjct: 839 RKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKA 898
Query: 673 MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKS 705
M +++ I+D+ K +LE+ K L+ S
Sbjct: 899 MHLSQLDMILDQTKTELEKKTNAVKELEKLQHS 931
Score = 46.8 bits (106), Expect = 3e-04
Identities = 73/386 (18%), Positives = 182/386 (47%), Gaps = 42/386 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKE----LATKFRQSHNNIDF 157
+++L + + + ++N +Q I + K+IE + + +++ ++KE +AT+++++ ID
Sbjct: 1077 KEQLREKEFIMLQN-EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEA---IDL 1132
Query: 158 NEIDRKLSKLRINNTN---CHTEHNAVQG-TDAEKVSAMINDMRSRIIELEKKCEALDNE 213
+ + +L++ ++ N++ H VQ + E++S+ + DM+ +L K+ +A N
Sbjct: 1133 GQ-ELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMK----QLSKEKDAHGNH 1187
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI 273
+ + EL + + VR++ L+ ++ + + + +E +K + + + +++
Sbjct: 1188 LAE---ELGASK----VREA---HLEARM---QAEIKKLSAEVESLKEAYHMEMISHQEN 1234
Query: 274 RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH 333
++KI ++ K+ + + + + K K++ E + ++ +L +Q ++++ E +E +
Sbjct: 1235 HAKWKISADSQKSSVQQLNEQ-LEKAKLELEEAQD----TVSNL-HQQVQDRNEVIEAAN 1288
Query: 334 SQLIIKEQEMKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L+ KE E+ +I +E +K F ++ + + Q K +
Sbjct: 1289 EALLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPD--VQDPKFAKCFHTSFS- 1345
Query: 393 LKYTLDLTNNQNSDLKQELNNLKNCKDELSTE-KFNFIEEIKTLKDELIEKTINYENEKN 451
K T + SDL +++ ++ +EL + K +E+ TL++ T +
Sbjct: 1346 -KCTKLRRSISASDLTFKIHGDEDLSEELLQDLKKMQLEQPSTLEESHKNLTYTQPDSFK 1404
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDI 477
L +E E N F T + R I
Sbjct: 1405 PLTYNLEADSSENNDFNTLSGMLRYI 1430
Score = 42.3 bits (95), Expect = 0.006
Identities = 66/359 (18%), Positives = 153/359 (42%), Gaps = 26/359 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKL 167
+ E++N + +Q+++ ++ + + Q L+E T + + EI+ K +L
Sbjct: 947 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1006
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
+ E N A +V+ + +R E+E+K L+ + ++EL +
Sbjct: 1007 -LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQ 1065
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK 287
I + ++ +E+L E + + +Q + +K + + + K + + + T+
Sbjct: 1066 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ 1125
Query: 288 LDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
+E + + ++ +E ++ H E+ Q+ ++ +E+L S+L +Q K K
Sbjct: 1126 Y-KEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQR--EIERLSSELEDMKQLSKEKD 1182
Query: 348 EQIEESASE--KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK--YTLDLTNNQ 403
A E K+ E E R Q+ I+ L E++ LK Y +++ ++Q
Sbjct: 1183 AHGNHLAEELGASKVREAHLEARMQA----------EIKKLSAEVESLKEAYHMEMISHQ 1232
Query: 404 NSDLKQEL--NNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ K ++ ++ K+ +L+ + +E+ K +E + N + N +E A
Sbjct: 1233 ENHAKWKISADSQKSSVQQLNEQ----LEKAKLELEEAQDTVSNLHQQVQDRNEVIEAA 1287
Score = 41.9 bits (94), Expect = 0.008
Identities = 65/279 (23%), Positives = 121/279 (43%), Gaps = 23/279 (8%)
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEE 291
D K L+EKL N+L QQ +V +H+L + ESI E + A + L+
Sbjct: 110 DQEIKSLREKL--NKLR----QQNACLVTQNHSLMTKF-ESIHFELT-QSRAKVSMLESA 161
Query: 292 KQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
+Q S ++++ + + S + +++L+E LEQ +I KEQ ++ E E
Sbjct: 162 QQQAASVPILEEQIINLEAEVSAQ---DKVLREAENKLEQSQKMVIEKEQSLQ---ESKE 215
Query: 352 ESASEKLKICE--IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
E K+ + E Q + + E E+ + +Q K++ L+ + L++
Sbjct: 216 ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 275
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
L N + L + E++ LK++L + N K KL + A+K E
Sbjct: 276 NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRI---MAVKNS---EV 329
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
+T +L L E +++ E L D+ ++ +E+
Sbjct: 330 MAQLTESRQSILKLE-SELENKDEILRDKFSLMNENREL 367
Score = 39.5 bits (88), Expect = 0.041
Identities = 67/328 (20%), Positives = 133/328 (40%), Gaps = 31/328 (9%)
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
++QEIK L+ L+ QN+ L + ++L + + E ++ L+ +
Sbjct: 109 VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 168
Query: 446 YENEKNKLNLAVEKAIKEK--NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
E+ +NL E + ++K + E L ++ +V L+ES E +L+ + T
Sbjct: 169 PILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQT 228
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
+ E + + +YK+ + L+ A I+E N+T + +
Sbjct: 229 KQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQA----EEEILERNLT---NCE 281
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXX 623
K G K+EL E+LK+ +++ L+EE + +
Sbjct: 282 KENKRLQERCGLYKSEL----EILKE----KLRQLKEENNNGKEKLRIMAVKNSEVMAQL 333
Query: 624 XXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIID 683
SR + + S LEN++E ++ + L EN EL + VA Q+ +D
Sbjct: 334 TESRQSILKLE---SELENKDE-----------ILRDKFSLMNENRELKVRVAAQNERLD 379
Query: 684 KLKKDLEQSQYTPKSPSVLRKSLKVGKE 711
++++E S+ +S + L + +E
Sbjct: 380 LCQQEIESSRVELRSLEKIISQLPLKRE 407
>X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy chain
(1085 AA) protein.
Length = 1085
Score = 78.2 bits (184), Expect = 1e-13
Identities = 116/539 (21%), Positives = 245/539 (45%), Gaps = 55/539 (10%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ KI ++ + EI + T + KQ DY E+ +L E L+E + I
Sbjct: 251 QKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV---TSTQI 307
Query: 156 DFNEI-DRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
+ N+ + + KLR + +H A+ T +K + + ++ +I L++ + L+ E
Sbjct: 308 ELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 367
Query: 215 YDKQMEL----SSLEEVITVR---DSLCKDLQEKLTS----NE-----LTLAETQQ-RLE 257
+ ++E+ SS+E V + + +C+ L+++L+ NE L+ TQ+ RL+
Sbjct: 368 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 427
Query: 258 MVKGHHALALEANESI-------RREYKIELEALKTKLDEEKQA------IISKCKVDQE 304
G + LE ESI ++ + + E LK +L+EE +A + + D +
Sbjct: 428 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALGHALQSSRHDCD 487
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
L+ ++ E K ++ + +A ++ E + + E++EE A +KL
Sbjct: 488 LLREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEE-AKKKLAQRLQD 545
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
EE+ +++ C+ EKT Q L+ E+++L ++ N+ + L ++ N E T+
Sbjct: 546 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 605
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
EE + + ++++ + E KL A E+A+ + + + LT +
Sbjct: 606 ----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 661
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
+ E+ + +LE + + K ++ L + L E++EA IL+ + L
Sbjct: 662 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL--------EHEEA--KILRIQLEL 711
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
T+ + I E ++ +++ R + T+++ L D E+ + +N I+ L++++E
Sbjct: 712 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL--DAEV--RRANEAIR-LKKKME 765
Score = 77.0 bits (181), Expect = 2e-13
Identities = 105/522 (20%), Positives = 225/522 (43%), Gaps = 49/522 (9%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + IL + Q D ++ KD C+ ++ED + Q Q+ +KEL + +
Sbjct: 205 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 264
Query: 152 HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
I+ R ++ + ++ E + + +A V+ S IEL KK EA
Sbjct: 265 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT-------STQIELNKKREA-- 315
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E + + LEE +++ L++K + L E L+ VK + E
Sbjct: 316 -EFLKLRRD---LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK-------QKLE 364
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENL-KTKHNASIESL-KNQMLKEKCEAL 329
+ E+K+E++ L + ++ +SK K + E + +T + E+ KN+ ++ L
Sbjct: 365 KEKSEFKLEIDDLSSSMES-----VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 419
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
S+L + E+ +LE+ +ES +L + F ++++ ++ ++ K L
Sbjct: 420 TTQKSRLQTEAGELSRQLEE-KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALGHA 478
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
++ ++ DL Q + ++ L+ + ++E + + +T + I++T E
Sbjct: 479 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEA 535
Query: 450 KNKLNLAV---EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
K KL + E+ ++ N SL T+ RL+ E+E L V+ S
Sbjct: 536 KKKLAQRLQDSEEQVEAVNAKCASLEKTKQ-------RLQ---GEVEDLMVDVERANSLA 585
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQ 563
L+ + + L +C+E + L LK +L+ E ++ E + +E+++
Sbjct: 586 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 645
Query: 564 NVEKEAYRELGTIKNELIEDVELLK--KESNSQIKFLREEVE 603
K +E+ + ++ E+ + + ++S QI+ + +++
Sbjct: 646 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 687
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 186/422 (44%), Gaps = 58/422 (13%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+D+ + ++EK+ A +N+V + ELS L+E I KLT + L E
Sbjct: 100 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA-----------KLTREKKALQEA 148
Query: 253 -QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHN 311
QQ L+ ++ N++ + + + ++E L++ L++EK K +VD E K K
Sbjct: 149 HQQALDDLQAEEDKVNSLNKT-KSKLEQQVEDLESSLEQEK-----KLRVDLERNKRKLE 202
Query: 312 ASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
++ + +L + + +QL +L K+ E ++E+ + +QF+++ +
Sbjct: 203 GDLKLAQESILDLENDK-QQLDERLKKKDFEYCQLQSKVEDE-----QTLGLQFQKKIKE 256
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
+Q I+ LE+EI+ + T T Q SD +EL +ELS +EE
Sbjct: 257 LQAR-------IEELEEEIEAERATRAKTEKQRSDYAREL-------EELSER----LEE 298
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
+ IE E E KL +E+A + V TLR + +DS
Sbjct: 299 AGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM------------VATLRKKHADS- 345
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
+ +L +Q+ L K+ LE E + +K +++ + ++ N+ K L + +
Sbjct: 346 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 405
Query: 552 MEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
N + SL + + R E G + +L E ++ + S S+ F ++ E KR L
Sbjct: 406 RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL 465
Query: 609 CE 610
E
Sbjct: 466 EE 467
Score = 69.3 bits (162), Expect = 4e-11
Identities = 128/624 (20%), Positives = 267/624 (42%), Gaps = 65/624 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + ++T + +Q+ED ++ + Q +++ +L R+ ++ + S
Sbjct: 156 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL----AQES 211
Query: 166 KLRINNTNCHTEHNAVQGTDAE--KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N + ++ D E ++ + + D ++ ++ +KK + L Q +
Sbjct: 212 ILDLENDKQQLDER-LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL-------QARIEE 263
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LEE I + +++ + L E +RLE G + +E N+ K E E
Sbjct: 264 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK------KREAEF 317
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQ 341
LK + D E+ + + V L+ KH S+ L Q+ L+ + LE+ S+ ++
Sbjct: 318 LKLRRDLEEATLQHEAMV--ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 375
Query: 342 EMKAKLEQIEESASEKLKIC---EIQFEE---RSQSIQEHCSQ---QEKTIQ----YLEQ 388
++ + +E + +S + KIC E Q E +++ IQ S+ Q+ +Q L +
Sbjct: 376 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 435
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+++E + + + Q+ LK +E + K +++ + + YE
Sbjct: 436 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALGHALQSSRHDCDLLREQYEE 495
Query: 449 E---KNKLNLAVEKAIKE----KNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLED 497
E K +L A+ KA E + K+ET ++ T ++ L RL++S+ ++E +
Sbjct: 496 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA 555
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+ L K+ L+ E+ L V + AL ++ + E E +
Sbjct: 556 KCASLEKTKQRLQGEV----EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 611
Query: 558 LIESLQNVEKEAYRELGTIKN---ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+E+ + EL +KN E ++ +E +K+E+ K L +E+ L E
Sbjct: 612 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN----KNLEQEIAD---LTEQ-IA 663
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
SR + AD+ +L E L ++L L Q E+
Sbjct: 664 ENGKTIHELEKSRKQIELEKADI-QLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRK 721
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKS 698
+A++ I++LK++ +++ T +S
Sbjct: 722 IAEKDEEIEQLKRNYQRTVETMQS 745
Score = 61.3 bits (142), Expect = 1e-08
Identities = 78/379 (20%), Positives = 163/379 (43%), Gaps = 31/379 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
++ +E V+A + + + ++T ++ED ++ + + L K R
Sbjct: 542 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN------- 594
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
D+ L++ + T C ++ + ++ +S + +++ E + E + E
Sbjct: 595 --FDKVLAEWK---TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 649
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+ + E++ L E I +L++ EL A+ Q LE + ALE E+
Sbjct: 650 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA----ALEHEEAKIL 705
Query: 276 EYKIELEALKTKLDE---EKQAIISKCKVD-QENLKTKHNASIESLKNQ----MLKEKCE 327
++EL +K+++D EK I + K + Q ++T +A ++ LK+K E
Sbjct: 706 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKME 765
Query: 328 A-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTI 383
L ++ QL ++ L+ + S +LK ++ ++ + ++E + E+
Sbjct: 766 GDLNEIEIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 824
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
L+ E++EL+ TL+ T +QEL + L T+ + I K L+ +L++
Sbjct: 825 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 884
Query: 444 INYENEKNKLNLAVEKAIK 462
E+ A EKA K
Sbjct: 885 SEVEDASRDARNAEEKAKK 903
Score = 59.3 bits (137), Expect = 5e-08
Identities = 51/232 (21%), Positives = 112/232 (48%), Gaps = 6/232 (2%)
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
E KTK DE ++ + +++++ + + L+ Q E E+ QLI +
Sbjct: 1 EFQKTK-DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF 59
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
+++AK++++ E A ++ +I + + + +++ CS+ +K I LE + +++ T
Sbjct: 60 QLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 118
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
N+ +L +EL+ L +L+ EK E + D+L + E++ N LN K
Sbjct: 119 NKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE----EDKVNSLNKTKSKLE 174
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
++ E+SL + + L R+ + +L+ ++ + L + K+ L+ L
Sbjct: 175 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERL 226
Score = 48.8 bits (111), Expect = 7e-05
Identities = 61/332 (18%), Positives = 145/332 (43%), Gaps = 25/332 (7%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS-------LEEVITVRDSLCKD 237
D ++ ++ + E K ++ ++ D Q+ L L+E + + +
Sbjct: 767 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 826
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIIS 297
LQ ++ TL +T++ ++ + L++NE ++ + + TK E +
Sbjct: 827 LQAEVEELRATLEQTERARKLAEQE---LLDSNERVQLLHTQNTSLIHTKKKLETDLMQL 883
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ +V+ + + NA E + + + E+L KEQ+ A LE+++++ +
Sbjct: 884 QSEVEDAS-RDARNA--EEKAKKAITDAAMMAEELK-----KEQDTSAHLERMKKNLEQT 935
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
+K + + +E Q + +Q IQ LE I+EL++ L+ +N++ + L +
Sbjct: 936 VKDLQHRLDEAEQLALKGGKKQ---IQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 992
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
EL+ + + + L+D + + + ++ K + A E+A KF + +
Sbjct: 993 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1052
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
R ++S++ +L + + TS++ V+
Sbjct: 1053 EE----RADIAESQVNKLRAKTRDFTSSRMVV 1080
>X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mRNA
for embryonic myosin heavy chain (SMHCE). ).
Length = 1085
Score = 78.2 bits (184), Expect = 1e-13
Identities = 113/532 (21%), Positives = 238/532 (44%), Gaps = 52/532 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ KI ++ + EI + T + KQ DY E+ +L E L+E + I
Sbjct: 251 QKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV---TSTQI 307
Query: 156 DFNEI-DRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
+ N+ + + KLR + +H A+ T +K + + ++ +I L++ + L+ E
Sbjct: 308 ELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 367
Query: 215 YDKQMEL----SSLEEVITVR---DSLCKDLQEKLTS----NE-----LTLAETQQ-RLE 257
+ ++E+ SS+E V + + +C+ L+++L+ NE L+ TQ+ RL+
Sbjct: 368 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 427
Query: 258 MVKGHHALALEANESI-------RREYKIELEALKTKLDEEKQA------IISKCKVDQE 304
G + LE ESI ++ + + E LK +L+EE +A + + D +
Sbjct: 428 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 487
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
L+ ++ E K ++ + +A ++ E + + E++EE A +KL
Sbjct: 488 LLREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEE-AKKKLAQRLQD 545
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
EE+ +++ C+ EKT Q L+ E+++L ++ N+ + L ++ N E T+
Sbjct: 546 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 605
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
EE + + ++++ + E KL A E+A+ + + + LT +
Sbjct: 606 ----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 661
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
+ E+ + +LE + + K ++ L + L E++EA IL+ + L
Sbjct: 662 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL--------EHEEA--KILRIQLEL 711
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
T+ + I E ++ +++ R + T+++ L D E+ + ++K
Sbjct: 712 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL--DAEVRSRNEAIRLK 761
Score = 77.4 bits (182), Expect = 2e-13
Identities = 105/522 (20%), Positives = 225/522 (43%), Gaps = 49/522 (9%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + IL + Q D ++ KD C+ ++ED + Q Q+ +KEL + +
Sbjct: 205 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 264
Query: 152 HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
I+ R ++ + ++ E + + +A V+ S IEL KK EA
Sbjct: 265 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT-------STQIELNKKREA-- 315
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E + + LEE +++ L++K + L E L+ VK + E
Sbjct: 316 -EFLKLRRD---LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK-------QKLE 364
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENL-KTKHNASIESL-KNQMLKEKCEAL 329
+ E+K+E++ L + ++ +SK K + E + +T + E+ KN+ ++ L
Sbjct: 365 KEKSEFKLEIDDLSSSMES-----VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 419
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
S+L + E+ +LE+ +ES +L + F ++++ ++ ++ K L
Sbjct: 420 TTQKSRLQTEAGELSRQLEE-KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 478
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
++ ++ DL Q + ++ L+ + ++E + + +T + I++T E
Sbjct: 479 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEA 535
Query: 450 KNKLNLAV---EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
K KL + E+ ++ N SL T+ RL+ E+E L V+ S
Sbjct: 536 KKKLAQRLQDSEEQVEAVNAKCASLEKTKQ-------RLQ---GEVEDLMVDVERANSLA 585
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQ 563
L+ + + L +C+E + L LK +L+ E ++ E + +E+++
Sbjct: 586 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 645
Query: 564 NVEKEAYRELGTIKNELIEDVELLK--KESNSQIKFLREEVE 603
K +E+ + ++ E+ + + ++S QI+ + +++
Sbjct: 646 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 687
Score = 70.5 bits (165), Expect = 2e-11
Identities = 128/624 (20%), Positives = 267/624 (42%), Gaps = 65/624 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + ++T + +Q+ED ++ + Q +++ +L R+ ++ + S
Sbjct: 156 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL----AQES 211
Query: 166 KLRINNTNCHTEHNAVQGTDAE--KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N + ++ D E ++ + + D ++ ++ +KK + L Q +
Sbjct: 212 ILDLENDKQQLDER-LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL-------QARIEE 263
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LEE I + +++ + L E +RLE G + +E N+ K E E
Sbjct: 264 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK------KREAEF 317
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQ 341
LK + D E+ + + V L+ KH S+ L Q+ L+ + LE+ S+ ++
Sbjct: 318 LKLRRDLEEATLQHEAMV--ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 375
Query: 342 EMKAKLEQIEESASEKLKIC---EIQFEE---RSQSIQEHCSQ---QEKTIQ----YLEQ 388
++ + +E + +S + KIC E Q E +++ IQ S+ Q+ +Q L +
Sbjct: 376 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 435
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+++E + + + Q+ LK +E + K +++ + + YE
Sbjct: 436 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 495
Query: 449 E---KNKLNLAVEKAIKE----KNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLED 497
E K +L A+ KA E + K+ET ++ T ++ L RL++S+ ++E +
Sbjct: 496 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA 555
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+ L K+ L+ E+ L V + AL ++ + E E +
Sbjct: 556 KCASLEKTKQRLQGEV----EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 611
Query: 558 LIESLQNVEKEAYRELGTIKN---ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+E+ + EL +KN E ++ +E +K+E+ K L +E+ L E
Sbjct: 612 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN----KNLEQEIAD---LTEQ-IA 663
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
SR + AD+ +L E L ++L L Q E+
Sbjct: 664 ENGKTIHELEKSRKQIELEKADI-QLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRK 721
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKS 698
+A++ I++LK++ +++ T +S
Sbjct: 722 IAEKDEEIEQLKRNYQRTVETMQS 745
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 186/422 (44%), Gaps = 58/422 (13%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+D+ + ++EK+ A +N+V + ELS L+E I KLT + L E
Sbjct: 100 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA-----------KLTREKKALQEA 148
Query: 253 -QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHN 311
QQ L+ ++ N++ + + + ++E L++ L++EK K +VD E K K
Sbjct: 149 HQQALDDLQAEEDKVNSLNKT-KSKLEQQVEDLESSLEQEK-----KLRVDLERNKRKLE 202
Query: 312 ASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
++ + +L + + +QL +L K+ E ++E+ + +QF+++ +
Sbjct: 203 GDLKLAQESILDLENDK-QQLDERLKKKDFEYCQLQSKVEDE-----QTLGLQFQKKIKE 256
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
+Q I+ LE+EI+ + T T Q SD +EL +ELS +EE
Sbjct: 257 LQAR-------IEELEEEIEAERATRAKTEKQRSDYAREL-------EELSER----LEE 298
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
+ IE E E KL +E+A + V TLR + +DS
Sbjct: 299 AGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM------------VATLRKKHADS- 345
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
+ +L +Q+ L K+ LE E + +K +++ + ++ N+ K L + +
Sbjct: 346 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 405
Query: 552 MEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
N + SL + + R E G + +L E ++ + S S+ F ++ E KR L
Sbjct: 406 RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL 465
Query: 609 CE 610
E
Sbjct: 466 EE 467
Score = 62.5 bits (145), Expect = 5e-09
Identities = 78/379 (20%), Positives = 164/379 (43%), Gaps = 31/379 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
++ +E V+A + + + ++T ++ED ++ + + L K R
Sbjct: 542 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN------- 594
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
D+ L++ + T C ++ + ++ +S + +++ E + E + E
Sbjct: 595 --FDKVLAEWK---TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 649
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+ + E++ L E I +L++ EL A+ Q LE + ALE E+
Sbjct: 650 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA----ALEHEEAKIL 705
Query: 276 EYKIELEALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCE 327
++EL +K+++D EK I + K + E +++ +A + S + LK+K E
Sbjct: 706 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 765
Query: 328 A-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTI 383
L ++ QL ++ L+ + S +LK ++ ++ + ++E + E+
Sbjct: 766 GDLNEIEIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 824
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
L+ E++EL+ TL+ T +QEL + L T+ + I K L+ +L++
Sbjct: 825 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 884
Query: 444 INYENEKNKLNLAVEKAIK 462
E+ A EKA K
Sbjct: 885 SEVEDASRDARNAEEKAKK 903
Score = 59.3 bits (137), Expect = 5e-08
Identities = 51/232 (21%), Positives = 112/232 (48%), Gaps = 6/232 (2%)
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
E KTK DE ++ + +++++ + + L+ Q E E+ QLI +
Sbjct: 1 EFQKTK-DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF 59
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
+++AK++++ E A ++ +I + + + +++ CS+ +K I LE + +++ T
Sbjct: 60 QLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 118
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
N+ +L +EL+ L +L+ EK E + D+L + E++ N LN K
Sbjct: 119 NKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE----EDKVNSLNKTKSKLE 174
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
++ E+SL + + L R+ + +L+ ++ + L + K+ L+ L
Sbjct: 175 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERL 226
Score = 49.2 bits (112), Expect = 5e-05
Identities = 99/466 (21%), Positives = 198/466 (42%), Gaps = 47/466 (10%)
Query: 78 FKITKAPNSSIKKTLTCPK-NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ 136
FK+ A ++ + T + NK L Q E+ + +I +TI E K + + E A
Sbjct: 628 FKLKNAYEEALDQLETVKRENKNLEQ-EIADLTE-QIAENGKTIHELEKSRKQIELEKAD 685
Query: 137 LQEILKELATKFRQSHNNI---------DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
+Q L+E I +EIDRK+++ + Q T
Sbjct: 686 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE---KDEEIEQLKRNYQRTVET 742
Query: 188 KVSAMINDMRSR--IIELEKKCEALDNEV-----YDKQMELSSLEEVITVRDSLCKDLQE 240
SA+ ++RSR I L+KK E NE+ + + +L+ + +V+ L KD Q
Sbjct: 743 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-KDTQL 801
Query: 241 KLTS---------NELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL----EALKT 286
L +L + E + L + A LE E R+ + EL E ++
Sbjct: 802 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 861
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL---EQLHSQLIIKEQEM 343
+ I +K K++ + ++ + S + +EK + + ++ + KEQ+
Sbjct: 862 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 921
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A LE+++++ + +K + + +E Q + +Q IQ LE I+EL++ L+ +
Sbjct: 922 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ---IQKLETRIRELEFELEGEQKK 978
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
N++ + L + EL+ + + + L+D + + + ++ K + A E+A
Sbjct: 979 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1038
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
KF + + R ++S++ +L + + TS++ V+
Sbjct: 1039 LTKFRKAQHELEEAEE----RADIAESQVNKLRAKTRDFTSSRMVV 1080
>D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 78.2 bits (184), Expect = 1e-13
Identities = 109/527 (20%), Positives = 230/527 (43%), Gaps = 58/527 (11%)
Query: 123 YNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF------------NEIDRKLSKLRIN 170
Y +Q+ED K ++ + + LA + + ++ D E+ R LSK
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 171 NTNCHTEH--NAVQGTDA-----EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
C T++ +A+Q T+ +K++ + D + + KC +L+ + Q E+
Sbjct: 1370 VAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L + ++ L +K + + LAE +Q+ E + LE+++ R EL
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE----LESSQKEARSLSTELFK 1485
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK +E + + K + +NL+ + + E L + LE++ QL +++ E+
Sbjct: 1486 LKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGEG--GKNVHELEKVRKQLEVEKLEL 1542
Query: 344 KAKLEQIEESAS-EKLKICEIQFE------ERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
++ LE+ E S E+ KI Q E E + + E + E+ + ++ + L+ +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 397 LDL-TNNQNSDL---KQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTINYE-- 447
LD T ++N L K+ +L + +LS E ++K+L+ L + I +
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 448 ---NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
N+ K N+A+ + + N + L R +V + +D EL + ++VQ+L S
Sbjct: 1663 VRANDDLKENIAIVE--RRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHS 1720
Query: 505 A-------KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
K+ ++ +L+ ++ + V+EC +E + A + +E + + +
Sbjct: 1721 QNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITHAAMMAEELKKEQDTSA- 1779
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
L+ ++K + + +++ L E ++ K Q++ L V +
Sbjct: 1780 ---HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Score = 75.8 bits (178), Expect = 5e-13
Identities = 127/630 (20%), Positives = 267/630 (42%), Gaps = 48/630 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ ++ + +Q++D + + Q +++ +L R+ ++ + S
Sbjct: 1012 LQAEEDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE----S 1067
Query: 166 KLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ + N E + D + ++ I D + ++L+KK + +N+ +++E
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK--ENQARIEELE---- 1121
Query: 225 EEVITVRDSLCKDLQEKLTSN-ELTLAETQQRLEMVKGHHALALEANESIRREY-KIELE 282
EE+ R + K EKL S+ L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1122 EELEAERTARAK--VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179
Query: 283 ALKTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ L E A + K D + +++ +K ++ KEK E +L EQ
Sbjct: 1180 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 342 EMKAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LEQEIKELKYT 396
+KAK LE++ + ++ ++ EE +S+ + +Q+ K L ++++E +
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQLEEKEAL 1299
Query: 397 LD-LTNN------QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
+ LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1359
Query: 450 KNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLTSA 505
+ L+ A + + + K+ET ++ T ++ L RL++++ +E + + L
Sbjct: 1360 QRVLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1420 KHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 566 EKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXXXX 619
+ EL +KN E +E +E K+E+ + +I L E++ +
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Query: 620 XXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVAKQ 678
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1536 EVEKLELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 679 SSIIDKLKKDLEQSQYTPKSPSVLRKSLKV 708
++D L+ L+ T VLR K+
Sbjct: 1593 QRVVDSLQTSLDAE--TRSRNEVLRVKKKM 1620
Score = 70.9 bits (166), Expect = 1e-11
Identities = 128/599 (21%), Positives = 259/599 (43%), Gaps = 68/599 (11%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE-------KLTSN 245
I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE L +
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1015
Query: 246 E---LTLAETQQRLEMVKGHHALALEANESIRREY-----KIELEALKTK-----LDEEK 292
E TL++++ +LE +LE + +R + K+E + T+ L+ +K
Sbjct: 1016 EDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 293 QAIISKCK-----VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
+ K K ++Q+N K + + + LKE +E+L +L E+ +AK+
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL-EAERTARAKV 1134
Query: 348 EQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYTLDLT---- 400
E++ S +L+ + EE + S+Q E ++E Q + ++++E + T
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 401 NNQNSD----LKQELNNLKNCKDELSTEKFNF---IEEIKTLKDELIEKTIN-------Y 446
+++D L ++++NL+ K +L EK F ++++ + +++I+ N
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE----DQVQML 502
E++ N+ + +E+A + N F T + + L+ +L E ++ + QL Q +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQLEEKEALISQLTRGKLSYTQQM 1314
Query: 503 TSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNILKSKA----ALTKEHTRIMEHN 555
K LE E + L + +CD +E ++KA L+K ++ + +
Sbjct: 1315 EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQCR 1374
Query: 556 VTL-IESLQNVE--KEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLC 609
+++Q E +EA ++L + E VE + + +S K L+ E+E V
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E +LA+ ++E E + + +L +E+
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 670 ELTMTVAKQSSIIDKLKKDL-EQSQYTPKSPSVL---RKSLKVGKENMQTISPLRERNL 724
E T +++ + + DL EQ K+ L RK L+V K +Q+ E +L
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL 1553
Score = 68.9 bits (161), Expect = 6e-11
Identities = 93/500 (18%), Positives = 216/500 (43%), Gaps = 33/500 (6%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E K++ K E +++E L++ + + E++ K+ L + + A
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRK---------ELEEKMVSLLQEKNDLQLQVQAE 896
Query: 182 QGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q DAE+ + + I+LE K + ++ + D++ + L + C +L+
Sbjct: 897 QDNLNDAEE---RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ + ELTLA+ ++ + E + E +L K L E Q +
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-DEIIAKLTKEKKALQEAHQQALDDL 1012
Query: 300 KVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+ +++ + T + ++ L+ Q+ L+ E +++ L +++++ L+ +ES +
Sbjct: 1013 QAEEDKVNTLSKSKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD- 1070
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN--SDLKQELNNLK 415
L+ ++Q EE+ + + +QQ I+ ++++ L+ L NQ +L++EL +
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIE--DEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIEK--TINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
+ ++ + + E++ + + L E + + E NK +A +K + + +
Sbjct: 1129 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK----KREAEFQKMRRDLEEAT 1184
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ LR + +DS + +L +Q+ L K+ LE E + +K L++ ++ +A
Sbjct: 1185 LQHEATAAALRKKHADS-VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 534 LVNILKSKAAL---TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
N+ K L E+ +E + + E G + +L E L+ +
Sbjct: 1244 KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQLEEKEALISQL 1303
Query: 591 SNSQIKFLREEVEKKRVLCE 610
+ ++ + ++ + KR L E
Sbjct: 1304 TRGKLSYTQQMEDLKRQLEE 1323
Score = 66.5 bits (155), Expect = 3e-10
Identities = 95/451 (21%), Positives = 189/451 (41%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + + E K + + E +L
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ ++ ++KK E NE+ +++LS + K LQ L ++
Sbjct: 1603 LDAETRS-RNEVLRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ D+E ++T
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLADRELIET 1711
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + ++ SQL + +E + EE A + + + EE
Sbjct: 1712 SERVQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITHAAMMAEEL 1771
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + + EL
Sbjct: 1772 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEA 1830
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E++K NL +D+V L
Sbjct: 1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR----------------LQDLVDKLQ 1874
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1905
Score = 62.9 bits (146), Expect = 4e-09
Identities = 81/367 (22%), Positives = 157/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AET++ + +K E E K ELE L +EK + + + +Q+NL
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
+E+C+ L + QL K +EM +LE EE +E
Sbjct: 901 NDA-------------EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE--------LT 939
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ +K I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 940 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L+ + K ++ + E SL + + L R
Sbjct: 1000 ALQEAHQQALDDLQAE----EDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1055
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K LE +L + N N+ + + L LK A
Sbjct: 1056 KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQA 1115
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 1176 MRRDLEE 1182
>BC086869-1|AAH86869.1| 954|Homo sapiens FLJ25770 protein protein.
Length = 954
Score = 78.2 bits (184), Expect = 1e-13
Identities = 116/556 (20%), Positives = 250/556 (44%), Gaps = 67/556 (12%)
Query: 97 NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID 156
N I Q E++Q Q RN++ Y +Q+ D ++ ++QL+ L+E +
Sbjct: 136 NSIQSQMEIIQEQ---ARNQNSM---YMRQLSDLESTVSQLRSELREAKRMYEDKTE--- 186
Query: 157 FNEIDRKLSKLRINNTNCHTEHNAVQ---GTDAEKVSAMINDM--RSRIIELEKK----- 206
E++++L T TE + G +++ ++ D+ R + + LEK+
Sbjct: 187 --ELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRL 244
Query: 207 ----------CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
+ L E+ ++ ME+ LE ++ S C+ E+ + + + L
Sbjct: 245 WDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMA---AIQGKNESL 301
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASI 314
E V A LE+ + + R+ EL A K L+ ++ I ++ ++E NA I
Sbjct: 302 EKVSSLTA-QLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEI 360
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI---QFEERSQS 371
L++++ K + L+ L ++ + ++ + E ++ +EK K+ EI Q E +Q
Sbjct: 361 TKLRSRV-DLKLQELQHLKNEGD-HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQL 418
Query: 372 IQEHC----------SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL 421
+ +H +Q EK I E+KELK D + + +L+ +++L+ K +L
Sbjct: 419 VGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKL 478
Query: 422 ---STEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
+E+ +++IK +D+L+ + +E N NL+ E + ++N F
Sbjct: 479 VNAGSERLRAVKDIKQERDQLLNEVKTSRSELN--NLSEEYEVLKRN-FRNKSEEMEMTT 535
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTS----AKEV---LENELTTYKNTLNNTVRECDEYK 531
+ L ++L+ + SELEQ + ++ + A +V ++ ++T + ++ + +
Sbjct: 536 NKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLE 595
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNV--EKEAYRELGTIKNELIEDVELLKK 589
EA+ N K K L +E +++ + T+ + E E R E + ++E+
Sbjct: 596 EAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALD 655
Query: 590 ESNSQIKFLREEVEKK 605
+++ Q ++ ++++
Sbjct: 656 KASLQFAECQDIIQRQ 671
Score = 65.3 bits (152), Expect = 7e-10
Identities = 107/519 (20%), Positives = 218/519 (42%), Gaps = 51/519 (9%)
Query: 209 ALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
A+ + + E+S L+ + V D L E EL L + Q R+E + H + +
Sbjct: 62 AISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEI 121
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
+ + +++++++ II + +Q ++ + + +ES +Q+ E E
Sbjct: 122 TGLTEKASSARSQANSIQSQME-----IIQEQARNQNSMYMRQLSDLESTVSQLRSELRE 176
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ--FEERSQSIQEHCSQQEKTIQY 385
A + E+++ ++ E+ +E+ + + +++ Q + ++EK +
Sbjct: 177 AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELS- 235
Query: 386 LEQEIKELKYTLDLTNNQNSD-LKQELNN-----------LKNCKDELSTEKFNFIEEIK 433
LE+E + + D N+ D L++EL+N LK K E + + I+
Sbjct: 236 LEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQ 295
Query: 434 TLKDELIEK----TINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESD 489
K+E +EK T E+ K L VE+ +K E+S D LT L+E +
Sbjct: 296 G-KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISD----LTTSLQEKE 350
Query: 490 SELEQLEDQVQMLTSAKEVLENELTTYKNT---LNNTVRECDEYKEALVN---ILKSKAA 543
+E ++ L S ++ EL KN L N EC+ K + +++
Sbjct: 351 RAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQ 410
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ T+++ + ++Q + + +E+ + EL +++++LK + +++I+ L V
Sbjct: 411 QIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMEL-KELKILKDKKDAKIRELEARVS 469
Query: 604 ----KKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVV 659
+K L LL + S L N +E Y V+
Sbjct: 470 DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYE---------VL 520
Query: 660 ELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKS 698
+ + R ++EE+ MT K + + +LEQ++ T KS
Sbjct: 521 KRNF-RNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKS 558
Score = 55.2 bits (127), Expect = 8e-07
Identities = 79/455 (17%), Positives = 191/455 (41%), Gaps = 24/455 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
++L+ +VEI + Q ++++ +QE + + + + ++++ + + +
Sbjct: 111 EQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLE-STVSQ 169
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
S+LR + + ++ + + R+ + ++ LD+++ +L
Sbjct: 170 LRSELR-EAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLH 228
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-NESIRREYKIEL 281
E+ +++ K L ++ T N +T+ ++ L+ + LEA ++++ E + ++
Sbjct: 229 KREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDN-RNMEVQRLEALLKALKSECQGQM 287
Query: 282 EALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESL--KNQMLKEKCEALEQLHSQLI 337
E + + +++ +S E+ K +E L K L+ + L + L
Sbjct: 288 ERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ 347
Query: 338 IKEQEMKAKLEQIEESASE-KLKICEIQF----EERSQSIQEHC-------SQQEKTIQY 385
KE+ ++A +I + S LK+ E+Q + +++Q C ++++K I+
Sbjct: 348 EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEI 407
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
L Q+I+ + + ++ E L+ E++ + ++E+K LKD+ K
Sbjct: 408 LRQQIENMTQLVGQHGRTAGAMQVEKAQLEK---EINDRRME-LKELKILKDKKDAKIRE 463
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E + L L K + ++ ++ + L ++ S SEL L ++ ++L
Sbjct: 464 LEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRN 523
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
E+ N L ++ E N LKS
Sbjct: 524 FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKS 558
Score = 54.4 bits (125), Expect = 1e-06
Identities = 87/420 (20%), Positives = 170/420 (40%), Gaps = 46/420 (10%)
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL-EANESIR 274
D ++ L +++ + + ++++ L E + + + H +L A I
Sbjct: 8 DSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKIL 67
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
RE E+ LK ++ + + E LK++ IE L L++ + +EQL S
Sbjct: 68 RELDTEISYLKGRIFPVEDQL--------EALKSESQNKIELL----LQQHQDRIEQLIS 115
Query: 335 QLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
+ ++ + K A+ +++I + Q ++ S E T+ L E++
Sbjct: 116 EHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELR 175
Query: 392 ELKYTL-DLTNNQNSDL---KQELNNLKNCKDELSTEKFNFIEEIKTLKDEL--IEKTIN 445
E K D T L EL + +D+ S E N ++++ L +L EK ++
Sbjct: 176 EAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELS 235
Query: 446 YENEKNK---------------LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR----LR 486
E E+NK L ++ E + E L + R ++
Sbjct: 236 LEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQ 295
Query: 487 ESDSELEQLEDQVQMLTSAKEVLE---NELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
+ LE++ L S KE+L ELT K TL ++ R + +L ++ A
Sbjct: 296 GKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEA 355
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
E T++ ++ LQ+++ E L ++ E E ++L E + I+ LR+++E
Sbjct: 356 TNAEITKLRSRVDLKLQELQHLKNEG-DHLRNVQTE-CEALKLQMTEKDKVIEILRQQIE 413
Score = 46.0 bits (104), Expect = 5e-04
Identities = 58/250 (23%), Positives = 101/250 (40%), Gaps = 14/250 (5%)
Query: 317 LKNQMLKEKCEALEQLHSQLIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
LK MLK+ +EQL ++ E QE+++ L EE++ + KICE + +
Sbjct: 1 LKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGK--KICE-HDSMSTLHFR 57
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN-----LKNCKDELSTEKFNF 428
S K ++ L+ EI LK + +Q LK E N L+ +D +
Sbjct: 58 SLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEH 117
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
EI L ++ + ++++ + E+A + + + LS V L LRE+
Sbjct: 118 EVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREA 177
Query: 489 DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEH 548
ED+ + L + +ELT + + +E + L +L KE
Sbjct: 178 K---RMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKEL 234
Query: 549 TRIMEHNVTL 558
+ E N L
Sbjct: 235 SLEKEQNKRL 244
>AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical
rhabdomyosarcoma antigen MU-RMS-40.3 protein.
Length = 941
Score = 78.2 bits (184), Expect = 1e-13
Identities = 113/532 (21%), Positives = 238/532 (44%), Gaps = 52/532 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ KI ++ + EI + T + KQ DY E+ +L E L+E + I
Sbjct: 107 QKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV---TSTQI 163
Query: 156 DFNEI-DRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEV 214
+ N+ + + KLR + +H A+ T +K + + ++ +I L++ + L+ E
Sbjct: 164 ELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 223
Query: 215 YDKQMEL----SSLEEVITVR---DSLCKDLQEKLTS----NE-----LTLAETQQ-RLE 257
+ ++E+ SS+E V + + +C+ L+++L+ NE L+ TQ+ RL+
Sbjct: 224 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 283
Query: 258 MVKGHHALALEANESI-------RREYKIELEALKTKLDEEKQA------IISKCKVDQE 304
G + LE ESI ++ + + E LK +L+EE +A + + D +
Sbjct: 284 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 343
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
L+ ++ E K ++ + +A ++ E + + E++EE A +KL
Sbjct: 344 LLREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEE-AKKKLAQRLQD 401
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
EE+ +++ C+ EKT Q L+ E+++L ++ N+ + L ++ N E T+
Sbjct: 402 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 461
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
EE + + ++++ + E KL A E+A+ + + + LT +
Sbjct: 462 ----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 517
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
+ E+ + +LE + + K ++ L + L E++EA IL+ + L
Sbjct: 518 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL--------EHEEA--KILRIQLEL 567
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK 596
T+ + I E ++ +++ R + T+++ L D E+ + ++K
Sbjct: 568 TQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL--DAEVRSRNEAIRLK 617
Score = 77.4 bits (182), Expect = 2e-13
Identities = 105/522 (20%), Positives = 225/522 (43%), Gaps = 49/522 (9%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + IL + Q D ++ KD C+ ++ED + Q Q+ +KEL + +
Sbjct: 61 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 120
Query: 152 HNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
I+ R ++ + ++ E + + +A V+ S IEL KK EA
Sbjct: 121 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT-------STQIELNKKREA-- 171
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E + + LEE +++ L++K + L E L+ VK + E
Sbjct: 172 -EFLKLRRD---LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK-------QKLE 220
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENL-KTKHNASIESL-KNQMLKEKCEAL 329
+ E+K+E++ L + ++ +SK K + E + +T + E+ KN+ ++ L
Sbjct: 221 KEKSEFKLEIDDLSSSMES-----VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 275
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
S+L + E+ +LE+ +ES +L + F ++++ ++ ++ K L
Sbjct: 276 TTQKSRLQTEAGELSRQLEE-KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 334
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
++ ++ DL Q + ++ L+ + ++E + + +T + I++T E
Sbjct: 335 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEA 391
Query: 450 KNKLNLAV---EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
K KL + E+ ++ N SL T+ RL+ E+E L V+ S
Sbjct: 392 KKKLAQRLQDSEEQVEAVNAKCASLEKTKQ-------RLQ---GEVEDLMVDVERANSLA 441
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQ 563
L+ + + L +C+E + L LK +L+ E ++ E + +E+++
Sbjct: 442 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 501
Query: 564 NVEKEAYRELGTIKNELIEDVELLK--KESNSQIKFLREEVE 603
K +E+ + ++ E+ + + ++S QI+ + +++
Sbjct: 502 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 543
Score = 70.5 bits (165), Expect = 2e-11
Identities = 128/624 (20%), Positives = 267/624 (42%), Gaps = 65/624 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + ++T + +Q+ED ++ + Q +++ +L R+ ++ + S
Sbjct: 12 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL----AQES 67
Query: 166 KLRINNTNCHTEHNAVQGTDAE--KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N + ++ D E ++ + + D ++ ++ +KK + L Q +
Sbjct: 68 ILDLENDKQQLDER-LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL-------QARIEE 119
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LEE I + +++ + L E +RLE G + +E N+ K E E
Sbjct: 120 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK------KREAEF 173
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQ 341
LK + D E+ + + V L+ KH S+ L Q+ L+ + LE+ S+ ++
Sbjct: 174 LKLRRDLEEATLQHEAMV--ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 231
Query: 342 EMKAKLEQIEESASEKLKIC---EIQFEE---RSQSIQEHCSQ---QEKTIQ----YLEQ 388
++ + +E + +S + KIC E Q E +++ IQ S+ Q+ +Q L +
Sbjct: 232 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 291
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+++E + + + Q+ LK +E + K +++ + + YE
Sbjct: 292 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 351
Query: 449 E---KNKLNLAVEKAIKE----KNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLED 497
E K +L A+ KA E + K+ET ++ T ++ L RL++S+ ++E +
Sbjct: 352 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA 411
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+ L K+ L+ E+ L V + AL ++ + E E +
Sbjct: 412 KCASLEKTKQRLQGEV----EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 467
Query: 558 LIESLQNVEKEAYRELGTIKN---ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+E+ + EL +KN E ++ +E +K+E+ K L +E+ L E
Sbjct: 468 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN----KNLEQEIAD---LTEQ-IA 519
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
SR + AD+ +L E L ++L L Q E+
Sbjct: 520 ENGKTIHELEKSRKQIELEKADI-QLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRK 577
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKS 698
+A++ I++LK++ +++ T +S
Sbjct: 578 IAEKDEEIEQLKRNYQRTVETMQS 601
Score = 62.5 bits (145), Expect = 5e-09
Identities = 78/379 (20%), Positives = 164/379 (43%), Gaps = 31/379 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
++ +E V+A + + + ++T ++ED ++ + + L K R
Sbjct: 398 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN------- 450
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
D+ L++ + T C ++ + ++ +S + +++ E + E + E
Sbjct: 451 --FDKVLAEWK---TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 505
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+ + E++ L E I +L++ EL A+ Q LE + ALE E+
Sbjct: 506 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA----ALEHEEAKIL 561
Query: 276 EYKIELEALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCE 327
++EL +K+++D EK I + K + E +++ +A + S + LK+K E
Sbjct: 562 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 621
Query: 328 A-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTI 383
L ++ QL ++ L+ + S +LK ++ ++ + ++E + E+
Sbjct: 622 GDLNEIEIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 680
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
L+ E++EL+ TL+ T +QEL + L T+ + I K L+ +L++
Sbjct: 681 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 740
Query: 444 INYENEKNKLNLAVEKAIK 462
E+ A EKA K
Sbjct: 741 SEVEDASRDARNAEEKAKK 759
Score = 62.1 bits (144), Expect = 7e-09
Identities = 78/411 (18%), Positives = 174/411 (42%), Gaps = 13/411 (3%)
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ALD ++ ++ +++SL + + + +DL+ L + + ++ ++G LA
Sbjct: 7 QALD-DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ 65
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEK 325
E+ + + K +L+ K D E + SK + D++ L + I+ L+ ++ L+E+
Sbjct: 66 ESILDLEND-KQQLDERLKKKDFEYCQLQSKVE-DEQTLGLQFQKKIKELQARIEELEEE 123
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
EA ++ + + +LE++ E E + Q E + E + + ++
Sbjct: 124 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR-RDLEE 182
Query: 386 LEQEIKELKYTLDLTNNQN-SDLKQELNNLKNCKDELSTEKFNF---IEEIKTLKDELIE 441
+ + + TL + + ++L ++++NL+ K +L EK F I+++ + + + +
Sbjct: 183 ATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 242
Query: 442 KTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
N E L + +A + + + SLS L E +LE+ E V
Sbjct: 243 SKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ 302
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIES 561
L+ +K+ + K L + + AL + L +++ E L +
Sbjct: 303 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 362
Query: 562 LQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKKRVLC 609
L E + + + I E++E KK+ +++ E+VE C
Sbjct: 363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 413
Score = 50.4 bits (115), Expect = 2e-05
Identities = 55/317 (17%), Positives = 134/317 (42%), Gaps = 13/317 (4%)
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
+QE Q +Q E ++ L T Q DL+ L K + +L K +
Sbjct: 1 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGD 60
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
+K ++ +++ EN+K +L+ ++K E + ++ + + + +++E +
Sbjct: 61 LKLAQESILD----LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQAR 116
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
+E+LE++++ + + E + + Y L E E E + ++ L K+ R
Sbjct: 117 IEELEEEIEAERATRAKTEKQRSDYAREL----EELSERLEEAGGVTSTQIELNKK--RE 170
Query: 552 MEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
E + L L+ + + T++ + + V L ++ ++ ++ +++++EK++ ++
Sbjct: 171 AEF-LKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDN-LQRVKQKLEKEKSEFKL 228
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADL-SRLENENERYXXXXXXXXSLVVELSLLRQENEE 670
S+ L + L +L + L + S L+ E E
Sbjct: 229 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE 288
Query: 671 LTMTVAKQSSIIDKLKK 687
L+ + ++ SI+ +L +
Sbjct: 289 LSRQLEEKESIVSQLSR 305
Score = 49.2 bits (112), Expect = 5e-05
Identities = 99/466 (21%), Positives = 198/466 (42%), Gaps = 47/466 (10%)
Query: 78 FKITKAPNSSIKKTLTCPK-NKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ 136
FK+ A ++ + T + NK L Q E+ + +I +TI E K + + E A
Sbjct: 484 FKLKNAYEEALDQLETVKRENKNLEQ-EIADLTE-QIAENGKTIHELEKSRKQIELEKAD 541
Query: 137 LQEILKELATKFRQSHNNI---------DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
+Q L+E I +EIDRK+++ + Q T
Sbjct: 542 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE---KDEEIEQLKRNYQRTVET 598
Query: 188 KVSAMINDMRSR--IIELEKKCEALDNEV-----YDKQMELSSLEEVITVRDSLCKDLQE 240
SA+ ++RSR I L+KK E NE+ + + +L+ + +V+ L KD Q
Sbjct: 599 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-KDTQL 657
Query: 241 KLTS---------NELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL----EALKT 286
L +L + E + L + A LE E R+ + EL E ++
Sbjct: 658 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 717
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL---EQLHSQLIIKEQEM 343
+ I +K K++ + ++ + S + +EK + + ++ + KEQ+
Sbjct: 718 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 777
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A LE+++++ + +K + + +E Q + +Q IQ LE I+EL++ L+ +
Sbjct: 778 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ---IQKLETRIRELEFELEGEQKK 834
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
N++ + L + EL+ + + + L+D + + + ++ K + A E+A
Sbjct: 835 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 894
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
KF + + R ++S++ +L + + TS++ V+
Sbjct: 895 LTKFRKAQHELEEAEE----RADIAESQVNKLRAKTRDFTSSRMVV 936
>BC103499-1|AAI03500.1| 898|Homo sapiens chromosome 10 open reading
frame 118 protein.
Length = 898
Score = 77.8 bits (183), Expect = 1e-13
Identities = 108/566 (19%), Positives = 236/566 (41%), Gaps = 39/566 (6%)
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
+H + +KV+ ++ ++RS + YD + ++ +V S +
Sbjct: 103 KHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSV--SASE 160
Query: 237 DLQEKLTSNELTLAETQQRLE--MVKGHHALALEANESIRREYKIELEALKTKLDEEK-- 292
DL E++ S L+ + R+ M KG HAL L + ++ +Y + +K + E K
Sbjct: 161 DLLEEIESELLSTEFAEHRVPNGMNKGEHALVL-FEKCVQDKYLQQEHIIKKLIKENKKH 219
Query: 293 -QAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQ-------LIIKEQE 342
+ + C +++NL+ + E+ K M +K+ +E+L+ + LI ++
Sbjct: 220 QELFVDICS-EKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDKLIAQDVT 278
Query: 343 MKAKLEQIEESASEKL----KICEIQFEERSQSIQEHCSQQEKTI------QYLEQEIKE 392
K ++Q+ + ++++ K CE +E+ + ++ +++++ + LE+++++
Sbjct: 279 AKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRD 338
Query: 393 LKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNK 452
L+ N+ L QE L + E I EI LK+++ I + +NK
Sbjct: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
L ++ + K+K ++ LT E+D + +D ++ ++E+ NE
Sbjct: 399 LKAEMDSHKETKDKL-------KETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 451
Query: 513 LTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE 572
L + + + K + + +K ++ R + + + +L+ K E
Sbjct: 452 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE 511
Query: 573 LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQ 632
++EL + E++ ++ ++I+ L ++V+ L E L
Sbjct: 512 RLRTEDELSKYKEIINRQ-KAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVE-SLNS 569
Query: 633 AAADLSR-LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ 691
DL + +E +R L + + L+ E+ L K S +L+ EQ
Sbjct: 570 LINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQ 629
Query: 692 SQYTP-KSPSVLRKSLKVGKENMQTI 716
+ T S L K ++ KE +QT+
Sbjct: 630 MKQTNINLESRLLKEEELRKEEVQTL 655
Score = 47.6 bits (108), Expect = 2e-04
Identities = 71/388 (18%), Positives = 164/388 (42%), Gaps = 34/388 (8%)
Query: 79 KITKAPNSSIKKTLTCPKN-KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
K+T+A + + C K + E +++ +++ + + T E KQ+++ +++
Sbjct: 419 KLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLR-VTKGELEKQMQEKSDQLEMH 477
Query: 138 QEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR 197
+KEL R +D +L LR C + + K +IN +
Sbjct: 478 HAKIKELEDLKRTFKEGMD------ELRTLR-TKVKCLEDERLRTEDELSKYKEIINRQK 530
Query: 198 SRI---IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ 254
+ I ++ K + L ++ + E+ +L+E + +SL DLQ+ + + +E
Sbjct: 531 AEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL 590
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
E + +A + S++ ++ K+ + + S+C ++ +T N
Sbjct: 591 FTERLTSKNAQLQSESNSLQSQFD--------KVSCSESQLQSQC---EQMKQTNINLES 639
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
LK + L++ E ++ L ++L ++ E+KA Q+EE E + Q + + SI++
Sbjct: 640 RLLKEEELRK--EEVQTLQAELACRQTEVKALSTQVEELKDELV----TQRRKHASSIKD 693
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q ++ + L+Q ++ Y ++++ + N ++ ++ S E +
Sbjct: 694 LTKQLQQARRKLDQ-VESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDN 752
Query: 435 L----KDELIEKTINYENEKNKLNLAVE 458
K LIE+ + + + N +E
Sbjct: 753 FPQVDKAMLIERIVRLQKAHARKNEKIE 780
>AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/d
protein.
Length = 1939
Score = 77.8 bits (183), Expect = 1e-13
Identities = 125/627 (19%), Positives = 261/627 (41%), Gaps = 56/627 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S +KK + + + ++ A + +++N + + ++ I E LQE ++
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 146 TKFRQSHNNIDFNEIDRKLSKL--RINNTNCHTEHNAVQGTDAEKVSAMIN-DMR---SR 199
+ + + N + + KL ++++ E D E+ + D++
Sbjct: 1012 DDLQAEEDKV--NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+++E + LD ++ K+ E+S L+ I +L LQ+K+ + + E ++ +E
Sbjct: 1070 AMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE 1129
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A A + + RE + E L + +++++++A K + D E +H
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + K++I ++ +
Sbjct: 1190 EATAATLR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEMKMEIDDL--ASNME 1240
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
++ + EK + LE ++ E+K + +DL + L+ E S + ++
Sbjct: 1241 TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ----LD 1296
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E TL +L + + +L +E+ IK K+ +L +R H L + +
Sbjct: 1297 EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSR---HDCDLLREQYEE 1353
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E + + ++ A + T Y+ E +E K+ L L+ +EH
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD----AEEHVE 1409
Query: 551 IMEHNVTLIE-SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+ +E + Q ++ E + ++ L KK+ N K L E +K C
Sbjct: 1410 AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD-KILAEWKQK----C 1464
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E SR L + +L +++N Y +L E L+QE
Sbjct: 1465 E---ETHAELEASQKESRSL----STELFKIKN---AYEESLDQLETLKRENKNLQQEIS 1514
Query: 670 ELTMTVA---KQSSIIDKLKKDLEQSQ 693
+LT +A K+ ++K+KK +EQ +
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEK 1541
Score = 62.1 bits (144), Expect = 7e-09
Identities = 110/522 (21%), Positives = 218/522 (41%), Gaps = 37/522 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T ++ED ++ + L K R D+
Sbjct: 1405 EEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRN---------FDK 1455
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
L++ + H E A Q ++ +S + +++ E + E L E + Q E+S
Sbjct: 1456 ILAEWKQKCEETHAELEASQ-KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E I +L++ E +E Q LE + +LE E ++EL
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEA----SLEHEEGKILRIQLELN 1570
Query: 283 ALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCEA-LEQLH 333
+K+++D EK I + K + E++++ +A I S + + LK+K E L ++
Sbjct: 1571 QVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1630
Query: 334 SQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE--RSQS-IQEHCSQQEKTIQYLEQEI 390
QL M A+ + + LK ++ ++ RSQ ++E + E+ L+ EI
Sbjct: 1631 IQLN-HANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEI 1689
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN-- 448
+EL+ TL+ T +QEL + L T+ + I K L+ ++ + E+
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 449 -EKNKLNLAVEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQMLT- 503
E +KAI + L +D H+ ++ L ++ +L+ D+ + L
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Query: 504 -SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
K+ ++ +L L V + V L+ KE T E + I L
Sbjct: 1810 KGGKKQIQ-KLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL 1868
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
Q++ + ++ + K + E+ E + S+ + ++ E+E+
Sbjct: 1869 QDLVDKLQAKVKSYKRQ-AEEAEEQSNVNLSKFRRIQHELEE 1909
Score = 61.3 bits (142), Expect = 1e-08
Identities = 82/423 (19%), Positives = 188/423 (44%), Gaps = 21/423 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + ++ K+ + +K + ++ L+ K ++ + L+ + EA E
Sbjct: 848 ETEKEMANMKEEFEKTKEEL-AKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A ++ +I + + + +++ CS+ +K I LE +
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +E+ L +L+ EK E + D+L + E++
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE----EDKV 1021
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N L A K ++ + E SL + I L R+ + +L+ ++ + + K+ L+
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQLD 1081
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+L + ++ + ++ ++AL L+ K KE +E IE+ + +A
Sbjct: 1082 EKLKKKEFEMSGLQSKIED-EQALGMQLQKK---IKELQARIEELEEEIEAERASRAKAE 1137
Query: 571 RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
++ + EL E E L++ + + +++ +M + L
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 631 AQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM---TVAKQSSIIDKLKK 687
+ A ++ L E+ L E S ++ E ++L TV+K ++K+ +
Sbjct: 1198 KKHADSVAEL---GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254
Query: 688 DLE 690
LE
Sbjct: 1255 ALE 1257
>AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein.
Length = 1978
Score = 77.8 bits (183), Expect = 1e-13
Identities = 127/655 (19%), Positives = 294/655 (44%), Gaps = 73/655 (11%)
Query: 124 NKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQG 183
+++I+D+++E++ LQ ++ T+ + H + ++ + ++ +L + V
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHRE-ELSDYEERIEELE---NLLQQGGSGVIE 281
Query: 184 TDAEKVSAM---INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
TD K+ M I ++ +E KK E L++++ D +LSS E RD L ++ QE
Sbjct: 282 TDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEND---RDILRRE-QE 337
Query: 241 KLTSNELTLAETQQRLEMVKGH-HALALEANESIRREYKI--------ELEALKTKLDEE 291
+L + + E + L++ A++ ++++ + +I E+ L+ L +
Sbjct: 338 QLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSGSVEEVFRLRQALSDA 397
Query: 292 KQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
+ I+ ++Q+N + N ++ ++ ++L+++ L Q +L + ++ + E I+
Sbjct: 398 ENEIMRLSSLNQDNSLAEDNLKLK-MRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456
Query: 352 ESASEKLKI------CEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTL---- 397
+A+ + + + E + Q + + S++E I +E Q + K+ +
Sbjct: 457 STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKA 516
Query: 398 DLTNNQN------SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN--- 448
L+ QN S LKQ+LN+ K +L +K + +E+ LI+ + +
Sbjct: 517 QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQFVLLIQSEVALNDLHL 576
Query: 449 EKNKLNLAVEKAIKEKNKF-ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
K KL VE + + NK E+++S+ ++ + L +R+++ EL ++ +++ +
Sbjct: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLE-LKEHIRQNEEELSRIRNELM-----QS 630
Query: 508 VLENELTTYKNTL-NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
+ ++ + +K+TL E K+ L + + L K + N L+ + ++V
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR 690
Query: 567 KE------AYRELGTIKNELIEDVELLKKESNSQI----KFLREEVEK-KRVLCEMXXXX 615
+ +L KN ++E +++ K E +++ K L EE K ++ + E+
Sbjct: 691 HQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNAR 750
Query: 616 XXXXXXXXXXSRVLLA---QAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELT 672
L+ + +++ L+ E+ + LS +E ++LT
Sbjct: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV---LSSSLEEQKQLT 807
Query: 673 MTVAKQSSIIDKLK-KDLEQSQYTPKSPSVLRKS---LKVGKENMQTISPLRERN 723
+ K+ I+KLK + + + K LRK+ + +E +++ ++E N
Sbjct: 808 QLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Score = 66.5 bits (155), Expect = 3e-10
Identities = 111/566 (19%), Positives = 237/566 (41%), Gaps = 41/566 (7%)
Query: 102 QDELVQA--QDVEIRNKDQTICEYNKQIEDYK---NEIAQLQEILKELATKFRQSHNNID 156
++EL+Q+ QD KD + E ++ + K +E+ QL E LK++A + + +
Sbjct: 624 RNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLV 683
Query: 157 F--NEIDRKLSKLRINNTNCHTEHNAVQGT---DAEKVSAMINDMRSRIIELEKKCEALD 211
++ +L + N E N + T + ++ A + + R++E K E
Sbjct: 684 LACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI 743
Query: 212 NEVYD-KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
E+ + + + S+L+ + L K Q+K ++ +AE ++ +E + H +
Sbjct: 744 EELSNARNLNTSALQ---LEHEHLIKLNQKK----DMEIAELKKNIEQMDTDHKETKDVL 796
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL-KNQMLKEKCEAL 329
S E K +L T+L +K+ I K K L+ + + ++L KN++L++ E
Sbjct: 797 SSSLEEQK-QL----TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEK 851
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
++ + + ++ +LE++ E S + + + + + SQ ++LE+E
Sbjct: 852 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE 911
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
IK + ++ +QN Q L +L+ K E+ ++ + T +EK ++
Sbjct: 912 IKHHQKIIE---DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 968
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE--DQVQMLTSAKE 507
+ + + +E+ +T S V +L + E+ SE L + +++ KE
Sbjct: 969 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI-ENGSEKHDLSKAETERLVKGIKE 1027
Query: 508 -VLENELTTYKN-TLNNTVREC--DEYKEALVNILKSKAALTKEHTRI--MEHNVTLIES 561
LE +L KN +L + + DE + I + + H RI H ++
Sbjct: 1028 RELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYL 1087
Query: 562 LQNVEKEAY--RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXX 619
Q ++ A ++ + NE + LK E + + + K+ L ++
Sbjct: 1088 QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLS 1144
Query: 620 XXXXXXSRVLLAQAAADLSRLENENE 645
+ + + +LSR+ E +
Sbjct: 1145 TRFESSGQDMFRETIQNLSRIIREKD 1170
Score = 66.1 bits (154), Expect = 4e-10
Identities = 97/515 (18%), Positives = 223/515 (43%), Gaps = 30/515 (5%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
+I + Q I + ++ ++E+ + I + + + + + ++ + +L+ N
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNR 225
Query: 172 TNCHTEH----NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL--SSLE 225
+ +H + +Q +K++ + R + + E++ E L+N + + + L
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLS 285
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
++ ++ ++ EK+ S + + + + +++ + + A + +RRE + +L K
Sbjct: 286 KIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAENDRDILRREQE-QLNVEK 343
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK- 344
++ EE + + +C Q + + + E + E + +L L E E+
Sbjct: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSGSVEEVFRLRQALSDAENEIMR 403
Query: 345 -AKLEQIEESASEKLKI-CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+ L Q A + LK+ I+ E+ +S+ SQ+++ +Q ++ + T
Sbjct: 404 LSSLNQDNSLAEDNLKLKMRIEVLEKEKSL---LSQEKEELQMSLLKLNNEYEVIKSTAT 460
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
++ L EL++L+ + E I E +TL E+ E ++ +N++ ++ + KA
Sbjct: 461 RDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE--LDRQNQEATKHMILIKAQL 518
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE---VLENELTTYKNT 519
K + E I+ L L + + QLED +T + VL + N
Sbjct: 519 SKQQNEGD-----SIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQFVLLIQSEVALND 573
Query: 520 LNNTVRECDEYKEALVNIL----KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
L+ T ++ ++ E LV+ L +S ++ KE+ + EH E L + E + L
Sbjct: 574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
N +D L KE ++++ L++ + + L E
Sbjct: 634 DSNSNFKDT--LLKEREAEVRNLKQNLSELEQLNE 666
Score = 55.2 bits (127), Expect = 8e-07
Identities = 109/538 (20%), Positives = 237/538 (44%), Gaps = 48/538 (8%)
Query: 102 QDELVQAQD---VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
Q+EL Q Q V+ N + +Y I+ Y+ +L+ +ELA + + S + N
Sbjct: 1243 QEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA-QVQHSIGQL-CN 1300
Query: 159 EIDRKLSKL-----RINNTNCHTEHNA--VQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
D L KL ++++ + T +A ++ + +E +S ++ + EL K + D
Sbjct: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE--------MVKGHH 263
+ Q L + I L + E+ S L E Q L+ ++K
Sbjct: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
L +NE+ + E E L+ + K+ I+ ++D LK ++ +E+ + + +
Sbjct: 1421 DQLLSSNENFTNKVN-ENELLRQAVTNLKERILI-LEMDIGKLKGENEKIVETYRGKETE 1478
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE--ERSQSIQEHCSQQEK 381
+ + ++++E+E + + + A E+L + Q + E +Q + S QEK
Sbjct: 1479 YQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1538
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
T+ + +QE ++ L +N+ L+ E+ L++ ++F +E++ L++ L+E
Sbjct: 1539 TVVF-QQERDQVMLALKQKQMENTALQNEVQRLRD-------KEFRSNQELERLRNHLLE 1590
Query: 442 KTINYENE----KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+Y E +++ +K + K +S + + H ++++ +L +
Sbjct: 1591 SEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSK 1650
Query: 498 QVQMLTSAKEVLENELTTYKNTLNN---TVRECDEYKEALVNI-LKSKAALTKEHTRIME 553
Q + T+ + L + Y+ +L N + + ++A+ + L+ + L E + E
Sbjct: 1651 Q-RDETALRFCLSGTVKQYRLSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAE 1709
Query: 554 HNVTLIESLQNVEKEAYRELGT---IKNEL---IEDVELLKKESNSQIKFLREEVEKK 605
+ + SLQ EA L + + +L E +E LK+++ + + L ++V+KK
Sbjct: 1710 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEML-DDVQKK 1766
Score = 42.7 bits (96), Expect = 0.004
Identities = 111/563 (19%), Positives = 237/563 (42%), Gaps = 76/563 (13%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
EI LQ+ ++++ T+ + +I + D + +K++ N +E + + + E++
Sbjct: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 192 MINDMRSRIIELEKKCEALDNEVYD-KQMELSSLEEVITVRDSLCKDLQEKLTSNELT-- 248
I + I L +K +L ++ + E+ L ++I +D + L +++S T
Sbjct: 1024 GIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD 1083
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK----CKVDQE 304
+ QQ+L+ +A+ E ++ E E LKT+ + + +K K+ E
Sbjct: 1084 VVYLQQQLQA----YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 1139
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
N K + ES M +E + L + II+E++++ ++ + + L + +
Sbjct: 1140 NKKL--STRFESSGQDMFRETIQNLSR-----IIREKDIE--IDALSQKCQTLLAVLQTS 1190
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+++ + +Q E+ +Q + LKQ++ ++ K ++ T
Sbjct: 1191 -STGNEAGGVNSNQFEELLQ------------------ERDKLKQQVKKMEEWKQQVMTT 1231
Query: 425 KFNFIEEIKTLKDEL--IEKTINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
N E L++EL ++ + +++ N KL + I+ + ET
Sbjct: 1232 VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET------------ 1279
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+L+ EL Q++ + L + K++L +L L++ + E L SK
Sbjct: 1280 --KLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECL---RASK 1334
Query: 542 AALTKEHTRIMEHNV-TLIESLQNVEKEA-YRELGTIKNELIEDV----ELLKKESNSQI 595
+ + E + +++ + L +SLQ EK+A R L + L + + EL +KE
Sbjct: 1335 SEVLSESSELLQQELEELRKSLQ--EKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1392
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE--RYXXXXXX 653
+++ EK+ VL ++ L + + + NENE R
Sbjct: 1393 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQ----LLSSNENFTNKVNENELLRQAVTNLK 1448
Query: 654 XXSLVVELSL--LRQENEELTMT 674
L++E+ + L+ ENE++ T
Sbjct: 1449 ERILILEMDIGKLKGENEKIVET 1471
Score = 37.9 bits (84), Expect = 0.13
Identities = 89/440 (20%), Positives = 179/440 (40%), Gaps = 33/440 (7%)
Query: 307 KTKHNASIESL---KNQMLKEKCEALEQLH--SQLIIKEQEM--KAKLEQIEESASEKLK 359
+TK +I ++ +N+ LK+ C LE+ H S++ IK+Q + +L+Q E S LK
Sbjct: 53 RTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISH-LK 111
Query: 360 ICEIQFEERSQSIQEHCSQ-----------QEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+I +++ +Q + Y + D+ +
Sbjct: 112 ARQIALQDQFLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQ 171
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK--NKLNLAVEKAIKEKNK 466
QE+N L N L +E ++ +T K + + + E K N + + +E +
Sbjct: 172 QEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDD 231
Query: 467 FETSLSVTRDI-VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ +SV ++ LT R EL E++++ L + +L+ + T + +
Sbjct: 232 HQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL---ENLLQQGGSGVIETDLSKIY 288
Query: 526 ECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTL--IESLQNVEKEAYRELGTIKNELIE 582
E + + L + ++S + + +I + N L E+ +++ + +L K +++E
Sbjct: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348
Query: 583 DVELLKKESN----SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
+ E LK E + S +K EK+R+L + + L+
Sbjct: 349 ECENLKLECSKLQPSAVKQSDTMTEKERILAQSGSVEEVFRLRQALSDAENEIMRLSSLN 408
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKS 698
+ + E L E SLL QE EEL M++ K ++ + +K +
Sbjct: 409 QDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSE 468
Query: 699 PSVLRKSLKVGKENM-QTIS 717
LR +L+ ++ + Q+IS
Sbjct: 469 LHDLRLNLEAKEQELNQSIS 488
>X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy
chain protein.
Length = 1934
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 74.5 bits (175), Expect = 1e-12
Identities = 102/527 (19%), Positives = 231/527 (43%), Gaps = 59/527 (11%)
Query: 123 YNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF------------NEIDRKLSKLRIN 170
Y +Q+ED K ++ + + LA + + ++ D E+ R LSK
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 171 NTNCHTEH--NAVQGTDA-----EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
T++ +A+Q T+ +K++ + + + + KC +L+ + Q E+
Sbjct: 1368 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L + ++ L +K + + LAE +Q+ E + LE+++ R EL
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE----LESSQKEARSLSTELFK 1483
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK +E + + K + +NL+ + + E L + + LE++ QL ++ E+
Sbjct: 1484 LKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGSS--GKTIHELEKVRKQLEAEKMEL 1540
Query: 344 KAKLEQIEESASE---KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE----IKELKYT 396
++ LE+ E S K+ +++F + I+ +++++ ++ ++ + L+ +
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 397 LDL-TNNQNSDL---KQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTINYE-- 447
LD T ++N L K+ +L + +LS E ++K+L+ L + I +
Sbjct: 1601 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1660
Query: 448 ---NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
N+ K N+A+ ++ +N + L R +V + +D EL + ++VQ+L S
Sbjct: 1661 VRANDDLKENIAI---VERRNNLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHS 1717
Query: 505 A-------KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
K+ ++ +L+ + + V+EC +E + A + +E + + +
Sbjct: 1718 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA- 1776
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
L+ ++K + + +++ L E ++ K Q++ L V +
Sbjct: 1777 ---HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1820
Score = 72.5 bits (170), Expect = 5e-12
Identities = 126/638 (19%), Positives = 259/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G + +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSCQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 67.3 bits (157), Expect = 2e-10
Identities = 135/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + V+ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRNVED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEEKQAIISK 298
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + + + +
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK-LTQE 1064
Query: 299 CKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESAS- 355
+D EN K + + ++ ++ L + E + L SQL K +E++A++E++EE
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 356 --------EKLKI-CEIQFEERSQSIQE-----HC-----SQQEKTIQYLEQEIKELKYT 396
EKL+ + EE S+ ++E C ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.5 bits (155), Expect = 3e-10
Identities = 96/451 (21%), Positives = 190/451 (42%), Gaps = 45/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + +TI E K + + E +L
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ + ++KK E NE+ +++LS + K LQ L ++
Sbjct: 1601 LDAETRS-RNEALRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N + ELE L+ +++ ++ S+ D+E ++T
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNN-----LQAELEELRAVVEQTER---SRKLADRELIET 1708
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + ++ SQL + +E + EE A + + + EE
Sbjct: 1709 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1768
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + ++EL
Sbjct: 1769 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1827
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E+++ NL +D+V L
Sbjct: 1828 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR----------------LQDLVDKLQ 1871
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 1872 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1902
Score = 66.1 bits (154), Expect = 4e-10
Identities = 84/414 (20%), Positives = 187/414 (45%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E ++L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A +++
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRNVE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 35.1 bits (77), Expect = 0.89
Identities = 31/154 (20%), Positives = 70/154 (45%), Gaps = 5/154 (3%)
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
KL ++ +K + E ++ ++ L L +S++ ++LE+++ L K L+
Sbjct: 831 KLYFKIKPLLKSAER-EKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE---KE 568
++ ++ L + CD+ + + + + + E N L +NVE E
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRNVEDECSE 949
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
R++ ++ L + VE K + +++K L EE+
Sbjct: 950 LKRDIDDLELTLAK-VEKEKHATENKVKNLTEEM 982
>X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal
mRNA for myosin heavy chain light meromyosin region. ).
Length = 876
Score = 77.4 bits (182), Expect = 2e-13
Identities = 100/535 (18%), Positives = 221/535 (41%), Gaps = 33/535 (6%)
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+++E + LD ++ K+ E+S L+ I +L LQ+K+ + + E ++ +E +
Sbjct: 8 MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER 67
Query: 261 GHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKHN 311
A A + + RE + E L + +++++++A K + D E +H
Sbjct: 68 TSRAKAEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKREAEFQKMRRDLEEATLQHE 127
Query: 312 ASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
A+ +L+ K+ +++ +L Q I Q +K KLE +E + K++I ++ ++
Sbjct: 128 ATAATLR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEMKMEIDDL--ASNMET 178
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
+ + EK + LE ++ E+K + +DL + L+ + E S + ++E
Sbjct: 179 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEYSRQ----LDE 234
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
TL+ +L + + +L +E+ IK K+ +L +R H L + + E
Sbjct: 235 KDTLETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSR---HDCDLLREQYEEE 291
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI 551
E + + ++ A + T Y+ E +E K+ L L+ +EH
Sbjct: 292 QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD----AEEHVEA 347
Query: 552 MEHNVTLIE-SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ--IKFLREEVEKKRVL 608
+ +E + Q ++ E + ++ L KK++N + +++ E+ +
Sbjct: 348 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKILAEWKQKCEETHAV 407
Query: 609 CEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQEN 668
E + ++ L L+ EN+ + E E
Sbjct: 408 LESFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 467
Query: 669 EELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
E++ V ++ S + ++ E S + +LR L+V + + + E++
Sbjct: 468 EKIKKQVEQEKSELQAALEEAEAS-LEHEEGKILRIQLEVNQVKSEVDRKIAEKD 521
Score = 74.9 bits (176), Expect = 9e-13
Identities = 124/634 (19%), Positives = 276/634 (43%), Gaps = 52/634 (8%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIA-QLQEILKELATKFRQSHNNIDFNEI-DRK 163
+QA+ E+ + + + E +++++ +L+EI + L + I+ N+ + +
Sbjct: 52 LQARIEELEEEIEAERTSRAKAEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKREAE 111
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL-- 221
K+R + +H A T +K + + ++ +I L++ + L+ E + +ME+
Sbjct: 112 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 171
Query: 222 --SSLEEVITVR---DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
S++E V + + +C+ L+++L S T E QQRL L+ N+
Sbjct: 172 LASNMETVSKAKGNLEKMCRALEDQL-SEIKTKEEEQQRLINDLTAQRARLQQNQVEYSR 230
Query: 277 YKIELEALKTKLDEEKQAI---ISKCKVD-QENLKTKHNA--SIESLKN--QMLKEKCE- 327
E + L+T+L KQA I + K +E +K K +++S ++ +L+E+ E
Sbjct: 231 QLDEKDTLETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 290
Query: 328 ------ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH------ 375
L++ S+ + + + K E +E+L+ + + +R Q +EH
Sbjct: 291 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNA 350
Query: 376 -CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
C+ EKT Q L+ E+++L ++ TN + L ++ N D++ E EE
Sbjct: 351 KCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNF----DKILAEWKQKCEETHA 406
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS---E 491
+ + +++ + E K+ A E+++ + + + + LT ++ E E
Sbjct: 407 VLESFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 466
Query: 492 LEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE+++ QV Q + + LE + ++ +R E + + + A +E +
Sbjct: 467 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEVNQVKSEVDRKIAEKDEEIDQ 526
Query: 551 IMEHNVTLIESLQ---NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK--- 604
+ +++ + ES+Q N E + + +K ++ D+ ++ + N + E++
Sbjct: 527 MKRNHIRIEESMQSTLNAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEDLRNYQN 586
Query: 605 -KRVLCE-MXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS 662
+ +L + ++ + + A+L + E E R + E
Sbjct: 587 TQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 646
Query: 663 LLRQENEELTMTVAKQSSIID---KLKKDLEQSQ 693
LL +E + + + +S+I+ KL+ D+ Q Q
Sbjct: 647 LL-DASERVQLLHTQNTSLINTKKKLETDISQIQ 679
Score = 68.5 bits (160), Expect = 8e-11
Identities = 108/517 (20%), Positives = 214/517 (41%), Gaps = 51/517 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR-KLS 165
Q D +++ K+ + +IED + QLQ+ +KEL + + I+ R K
Sbjct: 15 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERTSRAKAE 74
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
KLR ++ E + E V A S IE+ KK EA + Q LE
Sbjct: 75 KLR---SDLSRELEEISERLEEAVGA-----TSTQIEMNKKREA------EFQKMRRDLE 120
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
E ++ L++K + L E L+ VK + E + E K+E++ L
Sbjct: 121 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVK-------QKLEKEKSEMKMEIDDLA 173
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ ++ +SK K + E + +L++Q+ + K + EQ +LI +A
Sbjct: 174 SNME-----TVSKAKGNLEKM-------CRALEDQLSEIKTKEEEQ--QRLINDLTAQRA 219
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK---ELKYTLDLTNN 402
+L+Q + S +L + + S+ Q Q E+ + LE+EIK L + L + +
Sbjct: 220 RLQQNQVEYSRQLDEKDTLETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRH 279
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L+++ + K EL E+ + + I E + + + ++
Sbjct: 280 DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 339
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
+ + +++ + RL+ +E+E L V+ +A L+ + T + L
Sbjct: 340 DAEEHVEAVNAKCASLEKTKQRLQ---NEVEDLMIDVERTNAACAALDKKQTNFDKILAE 396
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRI---MEHNVTLIESLQNVEKEAYRELGTIKNE 579
++C+E L + K +L+ E +I E ++ +E+L+ K +E+ + +
Sbjct: 397 WKQKCEETHAVLESFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ 456
Query: 580 L------IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ I ++E +KK+ + L+ +E+ E
Sbjct: 457 IAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 493
Score = 58.4 bits (135), Expect = 8e-08
Identities = 98/453 (21%), Positives = 191/453 (42%), Gaps = 29/453 (6%)
Query: 174 CHTEHNAVQGTDAEK--VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
C H ++ E +S + +++ E + E L E + Q E+S L E I
Sbjct: 401 CEETHAVLESFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG 460
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE- 290
+L++ E +E Q LE + +LE E ++E+ +K+++D
Sbjct: 461 GKRIHELEKIKKQVEQEKSELQAALEEAEA----SLEHEEGKILRIQLEVNQVKSEVDRK 516
Query: 291 --EKQAIISKCKVD----QENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLIIKEQE 342
EK I + K + +E++++ NA I S + + LK+K E L ++ QL
Sbjct: 517 IAEKDEEIDQMKRNHIRIEESMQSTLNAEIRSRNDAIRLKKKMEGDLNEMEIQLN-HANR 575
Query: 343 MKAKLEQIEESASEKLKICEIQFEE--RSQS-IQEHCSQQEKTIQYLEQEIKELKYTLDL 399
M A+ + ++ LK ++ ++ RSQ ++E + E+ L+ EI+EL+ TL+
Sbjct: 576 MAAEDLRNYQNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 635
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN---EKNKLNLA 456
T +QEL + L T+ + I K L+ ++ + E+ E
Sbjct: 636 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIKEARNAEEK 695
Query: 457 VEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQMLT--SAKEVLEN 511
+KAI + L +D H+ ++ L ++ +L+ D+ + L K+ ++
Sbjct: 696 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ- 754
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
+L L V + V L KE T E + I LQ++ +
Sbjct: 755 KLEAKVRELEGEVESEQKRNVEAVKGLHKHERKVKELTYQTEEDRKNILRLQDLVDKLQA 814
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + K + E+ E + S+ + ++ E+E+
Sbjct: 815 KVKSYKRQ-AEEAEEQSNVNLSKFRRIQHELEE 846
>M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 74.5 bits (175), Expect = 1e-12
Identities = 127/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL S
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELESERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 67.7 bits (158), Expect = 1e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-ES 1124
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELESERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 64.1 bits (149), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 899 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 937
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 998 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1114 RIEELEEELESERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 1174 MRRDLEE 1180
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1458
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1459 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1572
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1630
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1869
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1870 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1905
>M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 74.5 bits (175), Expect = 1e-12
Identities = 127/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL S
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELESERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 67.7 bits (158), Expect = 1e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-ES 1124
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELESERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 64.1 bits (149), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 899 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 937
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 998 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1114 RIEELEEELESERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 1174 MRRDLEE 1180
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1458
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1459 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1572
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1630
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1869
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1870 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1905
>EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 73.3 bits (172), Expect = 3e-12
Identities = 126/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 67.3 bits (157), Expect = 2e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EA 1124
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 63.7 bits (148), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 899 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 937
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 998 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1114 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 1174 MRRDLEE 1180
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1458
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1459 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1572
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1630
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1869
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1870 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1905
>BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 77.4 bits (182), Expect = 2e-13
Identities = 121/556 (21%), Positives = 251/556 (45%), Gaps = 28/556 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQT--ICEYNKQIEDYKNEIAQ 136
KI +A +I++ + L +E +Q I+ + T +C K+ E +
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
E +E + NN + ++ +LR+ N E + D EK+ + +
Sbjct: 199 KYEYEREETRQVYMDLNN-NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNELTLA-ETQ 253
+ I + EK+ L ++ +K+ ++ L ++ L+E KL S L + E Q
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 254 QRLEMVKGHHALALEANESIRREYKIELE-ALKT--KLDEEKQAII---SKCKVDQENLK 307
L ++L+ + S ++ + +L+ A KT +L EEK+ + +K + +
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
T+ ++ SL+ ++L+ + + LE+ QL I E++ K ++EE ++ E++ EE
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-MTKLTNNKEVELEE 435
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ + E + + Q+ E+ +ELK T ++E+++L+ ++T +
Sbjct: 436 LKKVLGEKETLLYENKQF-EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 428 FIEEIKTLKDEL-IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH---VL 481
+ +E+K LK EL EK N E + NKL+L ++ +E + L ++ ++
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 482 TLRLRESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
R+ + L++ E Q++ L +E L+ + K L+ + C+ ++ + N K
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKE-SNSQI- 595
L +E+ + + + L E + + EL + K + E + +KE + +I
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 596 -KFLREEVEKKRVLCE 610
+ L EEVEK +V+ +
Sbjct: 675 EENLLEEVEKAKVIAD 690
Score = 72.5 bits (170), Expect = 5e-12
Identities = 113/517 (21%), Positives = 229/517 (44%), Gaps = 40/517 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQ----EILKELATKFRQSHNNIDFNEIDRKLS 165
+ E+R K+ + E K IE + I +LQ ++ +L +++ + I N R L
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL---- 221
L E + E+ + D+ + I ++ E L + + ++E+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKL 243
Query: 222 -SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR-EYKI 279
E++ + K++ +K L L + ++ +K L E+ + + + E K
Sbjct: 244 KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+L++ K EKQ ++K + E++K S+ + K L+E + + QL +
Sbjct: 304 KLQSENLKQSIEKQHHLTK---ELEDIKVSLQRSVSTQK--ALEEDLQIATKTICQL-TE 357
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E+E + + E + A+ + E FE S++E +++ ++ E ++K L T++L
Sbjct: 358 EKETQME-ESNKARAAHSFVVTE--FETTVCSLEELLRTEQQRLEKNEDQLKIL--TMEL 412
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++S+L +E+ L N K+ E +EE+K + E ++T+ YEN+ + E+
Sbjct: 413 -QKKSSEL-EEMTKLTNNKE---VE----LEELKKVLGE--KETLLYENK--QFEKIAEE 459
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS--AKEVLEN-ELTTY 516
+ + L VH L ++L + + +V+ L + E L+N ELT++
Sbjct: 460 LKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
N L+ +E + + LK++ + + E + IE+LQ E + EL +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 577 KNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ EL ++V+ +S LR++VE K E
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Score = 69.3 bits (162), Expect = 4e-11
Identities = 111/528 (21%), Positives = 228/528 (43%), Gaps = 43/528 (8%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
++K+ +E + Q ++ + K++ED K + + K L + + I
Sbjct: 293 RDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTI 352
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK---KCEALDN 212
+ K +++ +N H+ V V ++ +R+ LEK + + L
Sbjct: 353 -CQLTEEKETQMEESN-KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR---LEMVKGHHALA--- 266
E+ K EL + ++ ++ ++L++ L E L E +Q E +KG
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
L+A E + +I+L A+ T ++ + K + EN E LKN L C
Sbjct: 471 LQAREKEVHDLEIQLTAITTS-EQYYSKEVKDLKTELEN---------EKLKNTELTSHC 520
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
L + +L + +M +L+ +E + K E + ++ +++QE +Q ++Y+
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-EERMLKQIENLQETETQLRNELEYV 579
Query: 387 EQEIK----ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+E+K E+K LD + ++L++++ N +EL E + +K K K
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN----KALKK-KGTAESK 634
Query: 443 TIN-YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+N YE + NKL L +E A K KF +T + + ++ LE++E + ++
Sbjct: 635 QLNVYEIKVNKLELELESA---KQKFG---EITDTYQKEIEDKKISEENLLEEVE-KAKV 687
Query: 502 LTSAKEVLENELTTY-KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ L+ E+ ++ + V +++K I++ + + + + +L
Sbjct: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRA 747
Query: 561 SLQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKK 605
SL+ EL ++K +L E+ E LK+E+ L+E+ +KK
Sbjct: 748 SLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKK 795
Score = 52.0 bits (119), Expect = 7e-06
Identities = 94/418 (22%), Positives = 176/418 (42%), Gaps = 36/418 (8%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK+ L E E L +++S+L KE E K+++ + S +L+ E + +E + I+
Sbjct: 89 EGLKDSDL-ENSEGLSRVYSKLY-KEAE---KIKKWKVSTEAELRQKESKLQENRKIIEA 143
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q K IQ L+ +++ L+ +N DL +E N ++ + L E+ K
Sbjct: 144 ----QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E E Y + LN +EK I + +R +H +L+E +++
Sbjct: 200 YEYEREETRQVYMD----LNNNIEKMITAFEELRVQAENSRLEMH---FKLKEDYEKIQH 252
Query: 495 LEDQVQMLTSAKE----VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE + + + KE +L ++T +N + + +E ++ VN L+ K L E+ +
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK-VNQLEEKTKLQSENLK 311
Query: 551 -IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+E L + L++++ R + T K L ED+++ K I L EE E +
Sbjct: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKT----ICQLTEEKETQMEES 366
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
+ L + L E +R L +EL E E
Sbjct: 367 NKARAAHSFVVTEFETTVCSLEEL------LRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 670 ELTMTVAKQSSIIDKLKKDLEQSQ---YTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
E+T + +++LKK L + + Y K + + LK ++ + + RE+ +
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
>BC117174-1|AAI17175.1| 1291|Homo sapiens KIF15 protein protein.
Length = 1291
Score = 77.4 bits (182), Expect = 2e-13
Identities = 101/434 (23%), Positives = 194/434 (44%), Gaps = 35/434 (8%)
Query: 122 EYNKQ-IEDYKNEIAQLQEILKELATKF-RQSHNNIDFNEIDRKLSKLRINNTNCHTEHN 179
E N+Q E E+ +QE + L K + H N+ + KL +
Sbjct: 609 EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSER 668
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVIT---VRDSLCK 236
E++ + +N + ++ E + K + L +EV+D ++ L S ++ ++ + S K
Sbjct: 669 IDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFK 728
Query: 237 DLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQA 294
QEK N+L+ Q +L+ ++ + LE+ ++ Y E +K ++D+ +
Sbjct: 729 TNQEK-EFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRN 787
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESA 354
+ +N K K N +++S N ++ E EA ++ +++L ++ +E K E S+
Sbjct: 788 L--------QNFK-KENETLKSDLNNLM-ELLEAEKERNNKLSLQFEEDK------ENSS 831
Query: 355 SEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD-LTNNQNSDLKQELNN 413
E LK+ E +E+ + + C QQ +Q LE+ + + + L +++SD K+ + +
Sbjct: 832 KEILKVLEAVRQEKQKETAK-CEQQMAKVQKLEESLLATEKVISSLEKSRDSD-KKVVAD 889
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L N EL + E I TLK EL K IN + ++ + + +K + +
Sbjct: 890 LMNQIQELRSSVCEKTETIDTLKQEL--KDINCKYNSALVDREESRVLIKKQEVD----- 942
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
D+ L LR+ D E + L + + T +L + L + E + KEA
Sbjct: 943 ILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTK-KEA 1001
Query: 534 LVNILKSKAALTKE 547
L+ L+ K KE
Sbjct: 1002 LIQELQHKLNQKKE 1015
Score = 63.3 bits (147), Expect = 3e-09
Identities = 130/624 (20%), Positives = 253/624 (40%), Gaps = 47/624 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYK-NEIAQLQEILKELATKFRQSHNNIDFNEID 161
+++ Q +D+ + K + + NK I ++ ++I +L+++ KE F + +E+
Sbjct: 340 EKVTQLEDLTL--KKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELR 397
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
++ LR + H V E S + R R++E K+ + +D + K +
Sbjct: 398 NEIQTLREQIEH----HPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKA 453
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S + D + K A T+ +L+ L ++ E+K
Sbjct: 454 FSEISGMEKSDKNQQGFSPKAQKEPCLFANTE-KLKAQLLQIQTELNNSKQEYEEFKELT 512
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE---------QL 332
+ +L+ E Q++ K ++ ENL A +Q+ K E L+ QL
Sbjct: 513 RKRQLELESELQSL-QKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQL 571
Query: 333 HSQLIIK---EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
HS+ + K E L S + + E E ++ E S++ +T+Q ++
Sbjct: 572 HSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQ---EQ 628
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
+ L+ LD ++N L+Q ++ L++ ++ E F+ E I+ T E
Sbjct: 629 MSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQ-ELFS---------SERIDWTKQQEEL 678
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
++LN+ +EK ++E +T + VH L + L +D EL ++ + +S K
Sbjct: 679 LSQLNV-LEKQLQET---QTKNDFLKSEVHDLRVVLHSADKELSSVKLEY---SSFKTNQ 731
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
E E + + D + +L+SKA L + + E I+ L +
Sbjct: 732 EKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNF 791
Query: 570 YRELGTIKNELIEDVELL--KKESNSQIKFLREEVEK---KRVLCEMXXXXXXXXXXXXX 624
+E T+K++L +ELL +KE N+++ EE ++ K +L +
Sbjct: 792 KKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAK 851
Query: 625 XSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDK 684
+ + + S L E V L+ Q +EL +V +++ ID
Sbjct: 852 CEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQ-IQELRSSVCEKTETIDT 910
Query: 685 LKKDLEQSQYTPKSPSVLRKSLKV 708
LK++L+ S V R+ +V
Sbjct: 911 LKQELKDINCKYNSALVDREESRV 934
Score = 59.3 bits (137), Expect = 5e-08
Identities = 108/536 (20%), Positives = 231/536 (43%), Gaps = 40/536 (7%)
Query: 76 KAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIED-YKNEI 134
K K SS K NK+ + VQ Q +R +++ + E ++D Y N
Sbjct: 715 KELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDN-- 772
Query: 135 AQLQEILK-ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
LQEI+K E+ R N NE + + E N E+
Sbjct: 773 --LQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENS 830
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQM-ELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +++E ++ + + ++QM ++ LEE + + + L++ S++ +A+
Sbjct: 831 SKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADL 890
Query: 253 QQRLEMVKGHHALALEANESIRREYK-IELEALKTKLD-EEKQAIISKCKVDQENLKTKH 310
+++ ++ E +++++E K I + +D EE + +I K +VD +LK
Sbjct: 891 MNQIQELRSSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLK--- 947
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
E+L+ ++L E E + L L +++ E AS+K Q
Sbjct: 948 ----ETLRLRILSEDIER-DMLCEDLAHATEQLNMLTE-----ASKK-------HSGLLQ 990
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
S QE +++E IQ L+ ++ + K ++ N+ + ++L ++ + E +
Sbjct: 991 SAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAE-DPQSPKTPP 1049
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
+T +L+E T E E + A + +++ T L+ R++ + LR++E
Sbjct: 1050 HFQTHLAKLLE-TQEQEIEDGR---ASKTSLEH---LVTKLNEDREVKNAEILRMKEQLR 1102
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E+E L + Q L +L+ +L K N+ + + + L N + ++
Sbjct: 1103 EMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPD-NQQLKNEQEESIKERLAKSK 1161
Query: 551 IMEHNVTLIESLQNVEKEAY-RELGTIK-NELIEDVELLKKESNSQIKFLREEVEK 604
I+E + + L+ V+ Y +E+ ++ + +E + L+ ++ + + LR ++E+
Sbjct: 1162 IVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEE 1217
Score = 49.2 bits (112), Expect = 5e-05
Identities = 93/470 (19%), Positives = 186/470 (39%), Gaps = 52/470 (11%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
+ +L ++++ + + + + + + QI++ ++ + + E + L + + +
Sbjct: 863 EESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRSSVCEKTETIDTLKQELKDINCKY 922
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ +DR+ S++ I Q D + + +R RI+ + + + L ++
Sbjct: 923 NSALVDREESRVLIKK----------QEVD---ILDLKETLRLRILSEDIERDMLCEDLA 969
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
+L+ L E L + QE+LT E + E Q +L K E E +
Sbjct: 970 HATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKK-------EEVEQKKN 1022
Query: 276 EYKIELEALKTKLD---EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL-EQ 331
EY ++ L+ +D E+ Q+ + K E + K E L +
Sbjct: 1023 EYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTK 1082
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
L+ +K E+ EQ+ E E L++ Q E++ +Q +IK
Sbjct: 1083 LNEDREVKNAEILRMKEQLRE--MENLRLESQQLIEKNWLLQGQL-----------DDIK 1129
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE-KTINYENEK 450
K D + N LK E ++ K+ L+ K +EE+ +K +L E ++ Y E
Sbjct: 1130 RQKENSDQNHPDNQQLKNEQE--ESIKERLAKSK--IVEEMLKMKADLEEVQSALYNKEM 1185
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
L + E ++ E+ ++ L +L E E E+ +++ML E L
Sbjct: 1186 ECLRMTDE--VERTQTLESKAFQEKE---QLRSKLEEMYEERERTSQEMEMLRKQVECLA 1240
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
E K + + + +Y +V + K L +E ++ NV L E
Sbjct: 1241 EE--NGKLVGHQNLHQKIQY---VVRLKKENVRLAEETEKLRAENVFLKE 1285
>BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 73.3 bits (172), Expect = 3e-12
Identities = 126/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 67.3 bits (157), Expect = 2e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EA 1124
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 63.7 bits (148), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 899 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 937
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 998 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1114 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 1174 MRRDLEE 1180
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1458
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1459 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1572
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1630
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1869
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1870 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1905
>BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 73.3 bits (172), Expect = 3e-12
Identities = 126/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 67.3 bits (157), Expect = 2e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EA 1124
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 63.7 bits (148), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 899 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 937
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 998 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1114 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 1174 MRRDLEE 1180
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1458
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1459 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1572
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1630
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1869
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1870 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1905
>AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.7B protein.
Length = 1179
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 310 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 369
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 370 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 429
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 430 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 480
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 481 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQTENGELSRQ----LD 536
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 537 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 593
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 594 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 642
Score = 74.9 bits (176), Expect = 9e-13
Identities = 127/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 254 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 311
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 312 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 370
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 371 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 423
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 424 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 483
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQQ K L+ E EL LD
Sbjct: 484 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAK----LQTENGELSRQLDEKE 539
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 540 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 599
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 600 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 659
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 660 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 715
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 716 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 775
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 776 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 832
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 833 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 870
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 303 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 362
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 363 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 422
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 423 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 475
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 476 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQT-ENGELSRQ 534
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 535 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 593
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 594 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 653
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 654 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 713
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 714 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 773
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 774 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 831
Score = 67.3 bits (157), Expect = 2e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 134 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 190
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 191 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 250
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 251 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 309
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 310 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EA 368
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 369 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 428
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 429 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 487
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 488 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQQAKLQTENGELSRQL----DEKEA 540
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 541 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 596
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 597 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 656
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 657 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 709
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 710 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 746
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 79 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 137
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 138 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 188
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 189 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 247
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 248 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 307
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 308 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 363
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 364 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 423
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 424 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 475
Score = 63.7 bits (148), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 84 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 142
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 143 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 181
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 182 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 241
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 242 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 297
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 298 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 357
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 358 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 417
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 418 MRRDLEE 424
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 645 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 702
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 703 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 761
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 762 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 816
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 817 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 874
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 875 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 934
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 935 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 994
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 995 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1054
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1055 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1113
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1114 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1149
>AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 77.4 bits (182), Expect = 2e-13
Identities = 121/556 (21%), Positives = 251/556 (45%), Gaps = 28/556 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQT--ICEYNKQIEDYKNEIAQ 136
KI +A +I++ + L +E +Q I+ + T +C K+ E +
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
E +E + NN + ++ +LR+ N E + D EK+ + +
Sbjct: 199 KYEYEREETRQVYMDLNN-NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNELTLA-ETQ 253
+ I + EK+ L ++ +K+ ++ L ++ L+E KL S L + E Q
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 254 QRLEMVKGHHALALEANESIRREYKIELE-ALKT--KLDEEKQAII---SKCKVDQENLK 307
L ++L+ + S ++ + +L+ A KT +L EEK+ + +K + +
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
T+ ++ SL+ ++L+ + + LE+ QL I E++ K ++EE ++ E++ EE
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-MTKLTNNKEVELEE 435
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ + E + + Q+ E+ +ELK T ++E+++L+ ++T +
Sbjct: 436 LKKVLGEKETLLYENKQF-EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 428 FIEEIKTLKDEL-IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH---VL 481
+ +E+K LK EL EK N E + NKL+L ++ +E + L ++ ++
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 482 TLRLRESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
R+ + L++ E Q++ L +E L+ + K L+ + C+ ++ + N K
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKE-SNSQI- 595
L +E+ + + + L E + + EL + K + E + +KE + +I
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 596 -KFLREEVEKKRVLCE 610
+ L EEVEK +V+ +
Sbjct: 675 EENLLEEVEKAKVIAD 690
Score = 72.5 bits (170), Expect = 5e-12
Identities = 113/517 (21%), Positives = 229/517 (44%), Gaps = 40/517 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQ----EILKELATKFRQSHNNIDFNEIDRKLS 165
+ E+R K+ + E K IE + I +LQ ++ +L +++ + I N R L
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL---- 221
L E + E+ + D+ + I ++ E L + + ++E+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKL 243
Query: 222 -SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR-EYKI 279
E++ + K++ +K L L + ++ +K L E+ + + + E K
Sbjct: 244 KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+L++ K EKQ ++K + E++K S+ + K L+E + + QL +
Sbjct: 304 KLQSENLKQSIEKQHHLTK---ELEDIKVSLQRSVSTQK--ALEEDLQIATKTICQL-TE 357
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E+E + + E + A+ + E FE S++E +++ ++ E ++K L T++L
Sbjct: 358 EKETQME-ESNKARAAHSFVVTE--FETTVCSLEELLRTEQQRLEKNEDQLKIL--TMEL 412
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++S+L +E+ L N K+ E +EE+K + E ++T+ YEN+ + E+
Sbjct: 413 -QKKSSEL-EEMTKLTNNKE---VE----LEELKKVLGE--KETLLYENK--QFEKIAEE 459
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS--AKEVLEN-ELTTY 516
+ + L VH L ++L + + +V+ L + E L+N ELT++
Sbjct: 460 LKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
N L+ +E + + LK++ + + E + IE+LQ E + EL +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 577 KNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ EL ++V+ +S LR++VE K E
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Score = 69.3 bits (162), Expect = 4e-11
Identities = 111/528 (21%), Positives = 228/528 (43%), Gaps = 43/528 (8%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
++K+ +E + Q ++ + K++ED K + + K L + + I
Sbjct: 293 RDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTI 352
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK---KCEALDN 212
+ K +++ +N H+ V V ++ +R+ LEK + + L
Sbjct: 353 -CQLTEEKETQMEESN-KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR---LEMVKGHHALA--- 266
E+ K EL + ++ ++ ++L++ L E L E +Q E +KG
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
L+A E + +I+L A+ T ++ + K + EN E LKN L C
Sbjct: 471 LQAREKEVHDLEIQLTAITTS-EQYYSKEVKDLKTELEN---------EKLKNTELTSHC 520
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
L + +L + +M +L+ +E + K E + ++ +++QE +Q ++Y+
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-EERMLKQIENLQETETQLRNELEYV 579
Query: 387 EQEIK----ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+E+K E+K LD + ++L++++ N +EL E + +K K K
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN----KALKK-KGTAESK 634
Query: 443 TIN-YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+N YE + NKL L +E A K KF +T + + ++ LE++E + ++
Sbjct: 635 QLNVYEIKVNKLELELESA---KQKFG---EITDTYQKEIEDKKISEENLLEEVE-KAKV 687
Query: 502 LTSAKEVLENELTTY-KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ L+ E+ ++ + V +++K I++ + + + + +L
Sbjct: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRA 747
Query: 561 SLQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKK 605
SL+ EL ++K +L E+ E LK+E+ L+E+ +KK
Sbjct: 748 SLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKK 795
Score = 52.0 bits (119), Expect = 7e-06
Identities = 94/418 (22%), Positives = 176/418 (42%), Gaps = 36/418 (8%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK+ L E E L +++S+L KE E K+++ + S +L+ E + +E + I+
Sbjct: 89 EGLKDSDL-ENSEGLSRVYSKLY-KEAE---KIKKWKVSTEAELRQKESKLQENRKIIEA 143
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q K IQ L+ +++ L+ +N DL +E N ++ + L E+ K
Sbjct: 144 ----QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E E Y + LN +EK I + +R +H +L+E +++
Sbjct: 200 YEYEREETRQVYMD----LNNNIEKMITAFEELRVQAENSRLEMH---FKLKEDYEKIQH 252
Query: 495 LEDQVQMLTSAKE----VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE + + + KE +L ++T +N + + +E ++ VN L+ K L E+ +
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK-VNQLEEKTKLQSENLK 311
Query: 551 -IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+E L + L++++ R + T K L ED+++ K I L EE E +
Sbjct: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKT----ICQLTEEKETQMEES 366
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
+ L + L E +R L +EL E E
Sbjct: 367 NKARAAHSFVVTEFETTVCSLEEL------LRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 670 ELTMTVAKQSSIIDKLKKDLEQSQ---YTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
E+T + +++LKK L + + Y K + + LK ++ + + RE+ +
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
>AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 792
Score = 77.4 bits (182), Expect = 2e-13
Identities = 121/556 (21%), Positives = 251/556 (45%), Gaps = 28/556 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQT--ICEYNKQIEDYKNEIAQ 136
KI +A +I++ + L +E +Q I+ + T +C K+ E +
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
E +E + NN + ++ +LR+ N E + D EK+ + +
Sbjct: 199 KYEYEREETRQVYMDLNN-NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNELTLA-ETQ 253
+ I + EK+ L ++ +K+ ++ L ++ L+E KL S L + E Q
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 254 QRLEMVKGHHALALEANESIRREYKIELE-ALKT--KLDEEKQAII---SKCKVDQENLK 307
L ++L+ + S ++ + +L+ A KT +L EEK+ + +K + +
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
T+ ++ SL+ ++L+ + + LE+ QL I E++ K ++EE ++ E++ EE
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-MTKLTNNKEVELEE 435
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ + E + + Q+ E+ +ELK T ++E+++L+ ++T +
Sbjct: 436 LKKVLGEKETLLYENKQF-EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 428 FIEEIKTLKDEL-IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH---VL 481
+ +E+K LK EL EK N E + NKL+L ++ +E + L ++ ++
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 482 TLRLRESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
R+ + L++ E Q++ L +E L+ + K L+ + C+ ++ + N K
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKE-SNSQI- 595
L +E+ + + + L E + + EL + K + E + +KE + +I
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 596 -KFLREEVEKKRVLCE 610
+ L EEVEK +V+ +
Sbjct: 675 EENLLEEVEKAKVIAD 690
Score = 72.5 bits (170), Expect = 5e-12
Identities = 113/517 (21%), Positives = 229/517 (44%), Gaps = 40/517 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQ----EILKELATKFRQSHNNIDFNEIDRKLS 165
+ E+R K+ + E K IE + I +LQ ++ +L +++ + I N R L
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL---- 221
L E + E+ + D+ + I ++ E L + + ++E+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKL 243
Query: 222 -SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR-EYKI 279
E++ + K++ +K L L + ++ +K L E+ + + + E K
Sbjct: 244 KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+L++ K EKQ ++K + E++K S+ + K L+E + + QL +
Sbjct: 304 KLQSENLKQSIEKQHHLTK---ELEDIKVSLQRSVSTQK--ALEEDLQIATKTICQL-TE 357
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E+E + + E + A+ + E FE S++E +++ ++ E ++K L T++L
Sbjct: 358 EKETQME-ESNKARAAHSFVVTE--FETTVCSLEELLRTEQQRLEKNEDQLKIL--TMEL 412
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++S+L +E+ L N K+ E +EE+K + E ++T+ YEN+ + E+
Sbjct: 413 -QKKSSEL-EEMTKLTNNKE---VE----LEELKKVLGE--KETLLYENK--QFEKIAEE 459
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS--AKEVLEN-ELTTY 516
+ + L VH L ++L + + +V+ L + E L+N ELT++
Sbjct: 460 LKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
N L+ +E + + LK++ + + E + IE+LQ E + EL +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 577 KNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ EL ++V+ +S LR++VE K E
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Score = 52.0 bits (119), Expect = 7e-06
Identities = 94/418 (22%), Positives = 176/418 (42%), Gaps = 36/418 (8%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK+ L E E L +++S+L KE E K+++ + S +L+ E + +E + I+
Sbjct: 89 EGLKDSDL-ENSEGLSRVYSKLY-KEAE---KIKKWKVSTEAELRQKESKLQENRKIIEA 143
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q K IQ L+ +++ L+ +N DL +E N ++ + L E+ K
Sbjct: 144 ----QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E E Y + LN +EK I + +R +H +L+E +++
Sbjct: 200 YEYEREETRQVYMD----LNNNIEKMITAFEELRVQAENSRLEMH---FKLKEDYEKIQH 252
Query: 495 LEDQVQMLTSAKE----VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE + + + KE +L ++T +N + + +E ++ VN L+ K L E+ +
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK-VNQLEEKTKLQSENLK 311
Query: 551 -IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+E L + L++++ R + T K L ED+++ K I L EE E +
Sbjct: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKT----ICQLTEEKETQMEES 366
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
+ L + L E +R L +EL E E
Sbjct: 367 NKARAAHSFVVTEFETTVCSLEEL------LRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 670 ELTMTVAKQSSIIDKLKKDLEQSQ---YTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
E+T + +++LKK L + + Y K + + LK ++ + + RE+ +
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
Score = 48.4 bits (110), Expect = 9e-05
Identities = 74/350 (21%), Positives = 154/350 (44%), Gaps = 40/350 (11%)
Query: 107 QAQDVEIRNKDQTICE--YNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
+ D+EI+ T E Y+K+++D K E+ E LK + +++ E+ ++
Sbjct: 477 EVHDLEIQLTAITTSEQYYSKEVKDLKTELEN--EKLKNTELTSHCNKLSLENKELTQET 534
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
S + + N + N + + E++ I +++ +L + E + E+ K+ E+
Sbjct: 535 SDMTLELKNQQEDINNNKKQE-ERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK 593
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
+ + C +L++++ + + E QQ + +K A Y+I++ L
Sbjct: 594 ---LDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGT----AESKQLNVYEIKVNKL 646
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +L+ KQ Q+ ++ K S E+L LE++ +I ++ +K
Sbjct: 647 ELELESAKQKFGEITDTYQKEIEDK-KISEENL-----------LEEVEKAKVIADEAVK 694
Query: 345 AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN 404
+ E I+ K C+ + E +++H Q +K I+ + E+ K ++
Sbjct: 695 LQKE-ID-------KRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLR 746
Query: 405 SDLKQELNNLK----NCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+ L+ EL+NLK + K +L E+ EE + LK E E T + +K
Sbjct: 747 ASLEIELSNLKAELLSVKKQLEIER----EEKEKLKREAKENTATLKEKK 792
>AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 77.4 bits (182), Expect = 2e-13
Identities = 121/556 (21%), Positives = 251/556 (45%), Gaps = 28/556 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQT--ICEYNKQIEDYKNEIAQ 136
KI +A +I++ + L +E +Q I+ + T +C K+ E +
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
E +E + NN + ++ +LR+ N E + D EK+ + +
Sbjct: 199 KYEYEREETRQVYMDLNN-NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNELTLA-ETQ 253
+ I + EK+ L ++ +K+ ++ L ++ L+E KL S L + E Q
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 254 QRLEMVKGHHALALEANESIRREYKIELE-ALKT--KLDEEKQAII---SKCKVDQENLK 307
L ++L+ + S ++ + +L+ A KT +L EEK+ + +K + +
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
T+ ++ SL+ ++L+ + + LE+ QL I E++ K ++EE ++ E++ EE
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-MTKLTNNKEVELEE 435
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ + E + + Q+ E+ +ELK T ++E+++L+ ++T +
Sbjct: 436 LKKVLGEKETLLYENKQF-EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 428 FIEEIKTLKDEL-IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH---VL 481
+ +E+K LK EL EK N E + NKL+L ++ +E + L ++ ++
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 482 TLRLRESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
R+ + L++ E Q++ L +E L+ + K L+ + C+ ++ + N K
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKE-SNSQI- 595
L +E+ + + + L E + + EL + K + E + +KE + +I
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 596 -KFLREEVEKKRVLCE 610
+ L EEVEK +V+ +
Sbjct: 675 EENLLEEVEKAKVIAD 690
Score = 72.5 bits (170), Expect = 5e-12
Identities = 113/517 (21%), Positives = 229/517 (44%), Gaps = 40/517 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQ----EILKELATKFRQSHNNIDFNEIDRKLS 165
+ E+R K+ + E K IE + I +LQ ++ +L +++ + I N R L
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL---- 221
L E + E+ + D+ + I ++ E L + + ++E+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKL 243
Query: 222 -SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR-EYKI 279
E++ + K++ +K L L + ++ +K L E+ + + + E K
Sbjct: 244 KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+L++ K EKQ ++K + E++K S+ + K L+E + + QL +
Sbjct: 304 KLQSENLKQSIEKQHHLTK---ELEDIKVSLQRSVSTQK--ALEEDLQIATKTICQL-TE 357
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E+E + + E + A+ + E FE S++E +++ ++ E ++K L T++L
Sbjct: 358 EKETQME-ESNKARAAHSFVVTE--FETTVCSLEELLRTEQQRLEKNEDQLKIL--TMEL 412
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++S+L +E+ L N K+ E +EE+K + E ++T+ YEN+ + E+
Sbjct: 413 -QKKSSEL-EEMTKLTNNKE---VE----LEELKKVLGE--KETLLYENK--QFEKIAEE 459
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS--AKEVLEN-ELTTY 516
+ + L VH L ++L + + +V+ L + E L+N ELT++
Sbjct: 460 LKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
N L+ +E + + LK++ + + E + IE+LQ E + EL +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 577 KNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ EL ++V+ +S LR++VE K E
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Score = 69.3 bits (162), Expect = 4e-11
Identities = 111/528 (21%), Positives = 228/528 (43%), Gaps = 43/528 (8%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
++K+ +E + Q ++ + K++ED K + + K L + + I
Sbjct: 293 RDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTI 352
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK---KCEALDN 212
+ K +++ +N H+ V V ++ +R+ LEK + + L
Sbjct: 353 -CQLTEEKETQMEESN-KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR---LEMVKGHHALA--- 266
E+ K EL + ++ ++ ++L++ L E L E +Q E +KG
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
L+A E + +I+L A+ T ++ + K + EN E LKN L C
Sbjct: 471 LQAREKEVHDLEIQLTAITTS-EQYYSKEVKDLKTELEN---------EKLKNTELTSHC 520
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
L + +L + +M +L+ +E + K E + ++ +++QE +Q ++Y+
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-EERMLKQIENLQETETQLRNELEYV 579
Query: 387 EQEIK----ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+E+K E+K LD + ++L++++ N +EL E + +K K K
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN----KALKK-KGTAESK 634
Query: 443 TIN-YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+N YE + NKL L +E A K KF +T + + ++ LE++E + ++
Sbjct: 635 QLNVYEIKVNKLELELESA---KQKFG---EITDTYQKEIEDKKISEENLLEEVE-KAKV 687
Query: 502 LTSAKEVLENELTTY-KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ L+ E+ ++ + V +++K I++ + + + + +L
Sbjct: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRA 747
Query: 561 SLQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKK 605
SL+ EL ++K +L E+ E LK+E+ L+E+ +KK
Sbjct: 748 SLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKK 795
Score = 52.0 bits (119), Expect = 7e-06
Identities = 94/418 (22%), Positives = 176/418 (42%), Gaps = 36/418 (8%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK+ L E E L +++S+L KE E K+++ + S +L+ E + +E + I+
Sbjct: 89 EGLKDSDL-ENSEGLSRVYSKLY-KEAE---KIKKWKVSTEAELRQKESKLQENRKIIEA 143
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q K IQ L+ +++ L+ +N DL +E N ++ + L E+ K
Sbjct: 144 ----QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E E Y + LN +EK I + +R +H +L+E +++
Sbjct: 200 YEYEREETRQVYMD----LNNNIEKMITAFEELRVQAENSRLEMH---FKLKEDYEKIQH 252
Query: 495 LEDQVQMLTSAKE----VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE + + + KE +L ++T +N + + +E ++ VN L+ K L E+ +
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK-VNQLEEKTKLQSENLK 311
Query: 551 -IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+E L + L++++ R + T K L ED+++ K I L EE E +
Sbjct: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKT----ICQLTEEKETQMEES 366
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
+ L + L E +R L +EL E E
Sbjct: 367 NKARAAHSFVVTEFETTVCSLEEL------LRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 670 ELTMTVAKQSSIIDKLKKDLEQSQ---YTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
E+T + +++LKK L + + Y K + + LK ++ + + RE+ +
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
>AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1007
Score = 77.4 bits (182), Expect = 2e-13
Identities = 104/576 (18%), Positives = 242/576 (42%), Gaps = 33/576 (5%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ + N I +++ +L+EL+ F++ N+ +E +L+ ++ ++ +
Sbjct: 316 EVTEKCNHIREVKSLLEELS--FQKGELNVQISERKTQLTLIK----------QEIE-KE 362
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ-MELSSLEEVITVRDSLCKDLQEKLTS 244
E + ++ M EL+ + L E ++ Q ++L + V + + L+EKL
Sbjct: 363 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 422
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIE-LEALKTKLDEEKQAIISKCKVDQ 303
L QQ+ E+ L + E R + L++ L +EK+ + KC + +
Sbjct: 423 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 482
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ L + +N +++ LE+L + +QE+ +L + + S + +
Sbjct: 483 KKLAQTKRVLAAAEENSKMEQS--NLEKLELNVRKLQQELD-QLNRDKLSLHNDISAMQQ 539
Query: 364 QFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
Q +E+ + S+QE + + + +Q++ D+ ++ + L+++++ N ++
Sbjct: 540 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 599
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
E+ ++++ L++E+ E + ++ ++ E++K ETS ++ H
Sbjct: 600 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 659
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNI 537
L L + S+L+Q+ +V L+ E + + TL+ T R+ E ++ LV
Sbjct: 660 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 719
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF 597
AL KE + L K+A +++ ++K L ++ + E N
Sbjct: 720 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL--KIQRSQLEKN----L 773
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL--LAQAAADLSRLENENERYXXXXXXXX 655
L ++ E + EM R++ L Q + + L+ +
Sbjct: 774 LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQM 833
Query: 656 SLVVELSLLRQE-NEELTMTVAKQSSIIDKLKKDLE 690
+ + L+ E +E+ ++ + + +L DLE
Sbjct: 834 EISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 869
Score = 54.4 bits (125), Expect = 1e-06
Identities = 79/395 (20%), Positives = 169/395 (42%), Gaps = 31/395 (7%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINN 171
R ++ + E + I+D E L+ ++EL ++ DF ++ +++L I
Sbjct: 19 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK 78
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
+ H E + E + + RS + E ++ ++E+ + ++ L V V
Sbjct: 79 SLKHHEDIV---DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKVCLLV-VWGVS 134
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEE 291
K+ EK T + +L +T+ E L A E+ K + + + D +
Sbjct: 135 SVWTKNAVEKFTDAKRSLLQTESDAE------ELERRAQETAVNLVKADQQLRSLQADAK 188
Query: 292 KQAIISKCKVDQENLKTKHNASIESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
+ + K+ QE + + N + + + Q L +K E L + Q + K+ EM E+
Sbjct: 189 D---LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTE-ELQKLQKDIEMA---ER 241
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQ---QEKTIQYLEQEIKELKYTLDLTNNQNSD 406
E+ + LK E+ + + +++ SQ Q++ + L++++ K L L
Sbjct: 242 NEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQ 301
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
K +L + TEK N I E+K+L +EL +K +LN+ + + +
Sbjct: 302 AKADLQEALRLGETEVTEKCNHIREVKSLLEEL-------SFQKGELNVQISERKTQLTL 354
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+ + + + V+ ++ + +EL+ + D +Q+
Sbjct: 355 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQL 389
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/320 (20%), Positives = 136/320 (42%), Gaps = 21/320 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E K Q + +IE+ K ++ Q + + + L + + ++ +++ K + ++
Sbjct: 603 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 662
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
T+ + KV A +R+ + E E+ CE+L+ + + +LS E+ + +
Sbjct: 663 EL--TDQKSKLDQVLSKVLAAEERVRT-LQEEERWCESLEKTLSQTKRQLSEREQQLVEK 719
Query: 232 DSLCKDLQEKLTSN--ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD 289
LQ++ S + +L Q E K +A S++ KI+ L+ L
Sbjct: 720 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA-----SLKEALKIQRSQLEKNLL 774
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E+KQ + + K A+IE L Q E+ L + +Q+ + E+K ++
Sbjct: 775 EQKQ---------ENSCIQKEMATIE-LVAQDNHERARRLMKELNQMQYEYTELKKQMAN 824
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
++ +++I + +S+ E + + Q+L + +L+ L+ N +L+
Sbjct: 825 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 884
Query: 410 ELNNLKNCKDE-LSTEKFNF 428
NL +E EK NF
Sbjct: 885 LKENLPFTMNEGPFEEKLNF 904
Score = 43.2 bits (97), Expect = 0.003
Identities = 101/525 (19%), Positives = 218/525 (41%), Gaps = 44/525 (8%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEK-LTSNELTLAETQ 253
MR+ + EK+ E L + + D E SLE EV + ++ K Q+K + T+
Sbjct: 14 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 73
Query: 254 QRLEMVKGHHALALEANESIRR---EYKIEL-EALKTKLDEEKQAIISKCKV------DQ 303
+E HH ++ E I + + + EL EA + + E + +K KV
Sbjct: 74 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKVCLLVVWGV 133
Query: 304 ENLKTKHNAS-IESLKNQMLKEKCEA--LEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
++ TK+ K +L+ + +A LE+ + + + +L ++ A + L+
Sbjct: 134 SSVWTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKD-LEQ 192
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLE-------QEIKELKYTLDLTNNQNSDLKQELNN 413
+I+ EE + I + + ++ Q L +E+++L+ +++ Q L
Sbjct: 193 HKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKE 252
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
+ E ++ + + E+ ++K +L+L ++ K + +L +
Sbjct: 253 SEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRL 312
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKE--VLENELTTYKNTLNNTVRE 526
V +RE S LE+L Q VQ+ + +++ E+ + L +R+
Sbjct: 313 GETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ 372
Query: 527 CDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVE 585
++K L NIL L E+ + + + + +EK ++ ++ +L +E+++
Sbjct: 373 MSKHKTELKNILD---MLQLENHELQGLKLQHDQRVSELEK---TQVAVLEEKLELENLQ 426
Query: 586 LLKKESNSQIKFLREEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN 644
+ ++ +I++ ++ +E+ KR + M L++ DL +
Sbjct: 427 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKCDIW 481
Query: 645 ERYXXXXXXXXSLVVELSLLRQEN-EELTMTVAKQSSIIDKLKKD 688
E+ + E S + Q N E+L + V K +D+L +D
Sbjct: 482 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 526
Score = 37.1 bits (82), Expect = 0.22
Identities = 47/238 (19%), Positives = 101/238 (42%), Gaps = 14/238 (5%)
Query: 486 RESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT 545
R+S+ E+E+L + L K+ LE E+ L+ TV++ + K+ + ++S
Sbjct: 19 RQSEKEMEELHHNIDDLLQEKKSLECEV----EELHRTVQKRQQQKDFIDGNVES-LMTE 73
Query: 546 KEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
E + ++H+ +++ ++ +EK + ++EL E LL E+ S++ +E+V
Sbjct: 74 LEIEKSLKHHEDIVDEIECIEKTLLKR----RSELREADRLL-AEAESELSCTKEKV-CL 127
Query: 606 RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLR 665
V+ + ++ L Q +D LE + +L L+
Sbjct: 128 LVVWGVSSVWTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ---QLRSLQ 184
Query: 666 QENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
+ ++L KQ I+ ++ K + + S ++ L + +Q + ERN
Sbjct: 185 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 242
>AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1773
Score = 77.4 bits (182), Expect = 2e-13
Identities = 104/576 (18%), Positives = 242/576 (42%), Gaps = 33/576 (5%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ + N I +++ +L+EL+ F++ N+ +E +L+ ++ ++ +
Sbjct: 1082 EVTEKCNHIREVKSLLEELS--FQKGELNVQISERKTQLTLIK----------QEIE-KE 1128
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ-MELSSLEEVITVRDSLCKDLQEKLTS 244
E + ++ M EL+ + L E ++ Q ++L + V + + L+EKL
Sbjct: 1129 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1188
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIE-LEALKTKLDEEKQAIISKCKVDQ 303
L QQ+ E+ L + E R + L++ L +EK+ + KC + +
Sbjct: 1189 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1248
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ L + +N +++ LE+L + +QE+ +L + + S + +
Sbjct: 1249 KKLAQTKRVLAAAEENSKMEQS--NLEKLELNVRKLQQELD-QLNRDKLSLHNDISAMQQ 1305
Query: 364 QFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
Q +E+ + S+QE + + + +Q++ D+ ++ + L+++++ N ++
Sbjct: 1306 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1365
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
E+ ++++ L++E+ E + ++ ++ E++K ETS ++ H
Sbjct: 1366 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 1425
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNI 537
L L + S+L+Q+ +V L+ E + + TL+ T R+ E ++ LV
Sbjct: 1426 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 1485
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF 597
AL KE + L K+A +++ ++K L ++ + E N
Sbjct: 1486 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL--KIQRSQLEKN----L 1539
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL--LAQAAADLSRLENENERYXXXXXXXX 655
L ++ E + EM R++ L Q + + L+ +
Sbjct: 1540 LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQM 1599
Query: 656 SLVVELSLLRQE-NEELTMTVAKQSSIIDKLKKDLE 690
+ + L+ E +E+ ++ + + +L DLE
Sbjct: 1600 EISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 1635
Score = 62.1 bits (144), Expect = 7e-09
Identities = 86/406 (21%), Positives = 170/406 (41%), Gaps = 21/406 (5%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINN 171
R ++ + E + I+D E L+ ++EL ++ DF ++ +++L I
Sbjct: 798 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK 857
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITV 230
+ H E + E + + RS + E ++ ++E+ K+ +++E+
Sbjct: 858 SLKHHEDIV---DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 914
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL-ALEANESIRREYKIELEALKTKLD 289
+ SL LQ + + EL + + +VK L +L+A+ ++KI+ E + L
Sbjct: 915 KRSL---LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI---LK 968
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E + + +K Q K K + E K Q E E E H Q ++KE E+ L Q
Sbjct: 969 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ-VLKESEV---LLQ 1024
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTLDLTNNQNS 405
+ + EKLK ++ + +++ + L+ Q +L+ L L + +
Sbjct: 1025 AKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1084
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+ + +K+ +ELS +K +I K +L E E+ L + + + K K
Sbjct: 1085 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1144
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+ + L + + H L + D + +LE + K LEN
Sbjct: 1145 ELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1190
Score = 58.0 bits (134), Expect = 1e-07
Identities = 102/514 (19%), Positives = 219/514 (42%), Gaps = 45/514 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
E + +D+E + + I +D + I+ LQE L + + Q+ N +++
Sbjct: 36 ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKE 95
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
R+ + + DAE + + ++ S + E + +L D +
Sbjct: 96 TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAE 155
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LE + +RD+ L+E+L E RL ++ +++ E + E +A
Sbjct: 156 LEARLNLRDAEANQLKEEL--------EKVTRLTQLE---------QSALQAELEKERQA 198
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK L + + + + + + + K KH +L Q LK+ L + L ++ +E+
Sbjct: 199 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEV 257
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A+++++ KL E+ S + + + +K Q+ E + K+ D +
Sbjct: 258 AARVDELRRKL--KLGTGEMNIHSPSDVLGKSLADLQK--QFSE-ILARSKWERDEAQVR 312
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
L++E+ L+ +++L+T + EE + + +E +N++ +++ +++ E
Sbjct: 313 ERKLQEEM-ALQ--QEKLATGQ----EEFRQACERALEARMNFDKRQHEAR--IQQMENE 363
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-------LTTY 516
+ + +L +I + L+L+E+D E E++ Q++ L K++ + + L
Sbjct: 364 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 423
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
L V D+ A + I K + L H +M+ N E LQ E+ + R+
Sbjct: 424 LKKLKKAVATSDKLATAELTIAKDQ--LKSLHGTVMKINQERAEELQEAERFS-RKAAQA 480
Query: 577 KNELIE---DVELLKKESNSQIKFLREEVEKKRV 607
+L ++ELL+ + + R E+EK V
Sbjct: 481 ARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV 514
Score = 50.0 bits (114), Expect = 3e-05
Identities = 99/511 (19%), Positives = 210/511 (41%), Gaps = 29/511 (5%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEK-LTSNELTLAETQ 253
MR+ + EK+ E L + + D E SLE EV + ++ K Q+K + T+
Sbjct: 793 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 852
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKT--KLDEEKQAIISKCKVDQENLKTKHN 311
+E HH ++ E I + L+ +L E ++ +S K +N K
Sbjct: 853 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 912
Query: 312 ASIESL-KNQMLKEKCEALEQLHSQLIIK-EQEMKAKLEQIEESASEKLKICEIQFEERS 369
+ SL + + E+ E Q + ++K +Q++++ ++ K+K EI E
Sbjct: 913 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINK 972
Query: 370 QSIQEHCSQQ--EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q K + L +E+++L+ +++ Q L + E
Sbjct: 973 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1032
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
++ + + E+ ++K +L+L ++ K + +L + V +RE
Sbjct: 1033 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1092
Query: 488 SDSELEQLEDQ-----VQMLTSAKE--VLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
S LE+L Q VQ+ + +++ E+ + L +R+ ++K L NIL
Sbjct: 1093 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD- 1151
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLR 599
L E+ + + + + +EK ++ ++ +L +E+++ + ++ +I++ +
Sbjct: 1152 --MLQLENHELQGLKLQHDQRVSELEK---TQVAVLEEKLELENLQQISQQQKGEIEWQK 1206
Query: 600 EEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLV 658
+ +E+ KR + M L++ DL + E+ +
Sbjct: 1207 QLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1261
Query: 659 VELSLLRQEN-EELTMTVAKQSSIIDKLKKD 688
E S + Q N E+L + V K +D+L +D
Sbjct: 1262 EENSKMEQSNLEKLELNVRKLQQELDQLNRD 1292
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/320 (20%), Positives = 136/320 (42%), Gaps = 21/320 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E K Q + +IE+ K ++ Q + + + L + + ++ +++ K + ++
Sbjct: 1369 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1428
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
T+ + KV A +R+ + E E+ CE+L+ + + +LS E+ + +
Sbjct: 1429 EL--TDQKSKLDQVLSKVLAAEERVRT-LQEEERWCESLEKTLSQTKRQLSEREQQLVEK 1485
Query: 232 DSLCKDLQEKLTSN--ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD 289
LQ++ S + +L Q E K +A S++ KI+ L+ L
Sbjct: 1486 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA-----SLKEALKIQRSQLEKNLL 1540
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E+KQ + + K A+IE L Q E+ L + +Q+ + E+K ++
Sbjct: 1541 EQKQ---------ENSCIQKEMATIE-LVAQDNHERARRLMKELNQMQYEYTELKKQMAN 1590
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
++ +++I + +S+ E + + Q+L + +L+ L+ N +L+
Sbjct: 1591 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 1650
Query: 410 ELNNLKNCKDE-LSTEKFNF 428
NL +E EK NF
Sbjct: 1651 LKENLPFTMNEGPFEEKLNF 1670
Score = 33.5 bits (73), Expect = 2.7
Identities = 44/241 (18%), Positives = 105/241 (43%), Gaps = 18/241 (7%)
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
+ N+ ++ L+++ S++ + +E+K EQ+ E + + E +QE+
Sbjct: 14 IMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYL 73
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
+ + E ++L+ ++ L Q L ++ +D+L + + ++
Sbjct: 74 GTIKGQATQAQNECRKLR-------DEKETLLQRLTEVEQERDQLEIVAM----DAENMR 122
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
EL E + E++++N ++++ + + +E L ++ +L+E ELE++
Sbjct: 123 KELAELESALQ-EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE---ELEKVT 178
Query: 497 DQVQMLTSAKEV-LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
Q+ SA + LE E KN L + E KE + L +K ++ +++
Sbjct: 179 RLTQLEQSALQAELEKERQALKNALGKA--QFSEEKEQENSELHAKLKHLQDDNNLLKQQ 236
Query: 556 V 556
+
Sbjct: 237 L 237
>AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110kDa
protein.
Length = 2325
Score = 77.4 bits (182), Expect = 2e-13
Identities = 104/576 (18%), Positives = 242/576 (42%), Gaps = 33/576 (5%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ + N I +++ +L+EL+ F++ N+ +E +L+ ++ ++ +
Sbjct: 1634 EVTEKCNHIREVKSLLEELS--FQKGELNVQISERKTQLTLIK----------QEIE-KE 1680
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ-MELSSLEEVITVRDSLCKDLQEKLTS 244
E + ++ M EL+ + L E ++ Q ++L + V + + L+EKL
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIE-LEALKTKLDEEKQAIISKCKVDQ 303
L QQ+ E+ L + E R + L++ L +EK+ + KC + +
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ L + +N +++ LE+L + +QE+ +L + + S + +
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQS--NLEKLELNVRKLQQELD-QLNRDKLSLHNDISAMQQ 1857
Query: 364 QFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
Q +E+ + S+QE + + + +Q++ D+ ++ + L+++++ N ++
Sbjct: 1858 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1917
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
E+ ++++ L++E+ E + ++ ++ E++K ETS ++ H
Sbjct: 1918 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 1977
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNI 537
L L + S+L+Q+ +V L+ E + + TL+ T R+ E ++ LV
Sbjct: 1978 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF 597
AL KE + L K+A +++ ++K L ++ + E N
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL--KIQRSQLEKN----L 2091
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL--LAQAAADLSRLENENERYXXXXXXXX 655
L ++ E + EM R++ L Q + + L+ +
Sbjct: 2092 LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQM 2151
Query: 656 SLVVELSLLRQE-NEELTMTVAKQSSIIDKLKKDLE 690
+ + L+ E +E+ ++ + + +L DLE
Sbjct: 2152 EISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 2187
Score = 62.1 bits (144), Expect = 7e-09
Identities = 86/406 (21%), Positives = 170/406 (41%), Gaps = 21/406 (5%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINN 171
R ++ + E + I+D E L+ ++EL ++ DF ++ +++L I
Sbjct: 1350 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK 1409
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITV 230
+ H E + E + + RS + E ++ ++E+ K+ +++E+
Sbjct: 1410 SLKHHEDIV---DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 1466
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL-ALEANESIRREYKIELEALKTKLD 289
+ SL LQ + + EL + + +VK L +L+A+ ++KI+ E + L
Sbjct: 1467 KRSL---LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI---LK 1520
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E + + +K Q K K + E K Q E E E H Q ++KE E+ L Q
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ-VLKESEV---LLQ 1576
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTLDLTNNQNS 405
+ + EKLK ++ + +++ + L+ Q +L+ L L + +
Sbjct: 1577 AKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1636
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+ + +K+ +ELS +K +I K +L E E+ L + + + K K
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1696
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+ + L + + H L + D + +LE + K LEN
Sbjct: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742
Score = 60.5 bits (140), Expect = 2e-08
Identities = 86/400 (21%), Positives = 173/400 (43%), Gaps = 28/400 (7%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQ----DVEIRNKDQTICEY---NKQIEDYKNEIAQLQ 138
S K+ + ++ I+ + VQ + D ++RN + + + Q+ED + +I+ Q
Sbjct: 391 SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
Query: 139 EILKELATKFRQSHNNI-----DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
L EL + ++ I +F +++ + +I+ + + G ++
Sbjct: 451 TRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGR-----LQLV 505
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
N +R ++LE + E E+ KQ E+ L+ I DS KD + + + E Q
Sbjct: 506 NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS--KDPKHSHMKAQKSGKEQQ 563
Query: 254 QRLEMVKGHHALALEANESIRREYK--IELEALKTKLDEEKQAIISKCKVDQENLKTKHN 311
+ M K + L +E + R K E++ L+ +L E + A K D E + +
Sbjct: 564 LDI-MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQ 622
Query: 312 ASIESLKNQ--MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESA--SEKLKICEIQFEE 367
+ ++K Q + +C L L+ + E++ + +Q+E A +E ++ + E
Sbjct: 623 EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD-ELSTEKF 426
Q E + ++T L EL+ L+L + + + LK+EL + E S +
Sbjct: 683 ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQA 742
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNL-AVEKAIKEKN 465
+E + LK+ L + + E E+ L A K +++ N
Sbjct: 743 ELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
Score = 58.0 bits (134), Expect = 1e-07
Identities = 102/514 (19%), Positives = 219/514 (42%), Gaps = 45/514 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
E + +D+E + + I +D + I+ LQE L + + Q+ N +++
Sbjct: 588 ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKE 647
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
R+ + + DAE + + ++ S + E + +L D +
Sbjct: 648 TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAE 707
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LE + +RD+ L+E+L E RL ++ +++ E + E +A
Sbjct: 708 LEARLNLRDAEANQLKEEL--------EKVTRLTQLE---------QSALQAELEKERQA 750
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK L + + + + + + + K KH +L Q LK+ L + L ++ +E+
Sbjct: 751 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEV 809
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A+++++ KL E+ S + + + +K Q+ E + K+ D +
Sbjct: 810 AARVDELRRKL--KLGTGEMNIHSPSDVLGKSLADLQK--QFSE-ILARSKWERDEAQVR 864
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
L++E+ L+ +++L+T + EE + + +E +N++ +++ +++ E
Sbjct: 865 ERKLQEEM-ALQ--QEKLATGQ----EEFRQACERALEARMNFDKRQHEAR--IQQMENE 915
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-------LTTY 516
+ + +L +I + L+L+E+D E E++ Q++ L K++ + + L
Sbjct: 916 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
L V D+ A + I K + L H +M+ N E LQ E+ + R+
Sbjct: 976 LKKLKKAVATSDKLATAELTIAKDQ--LKSLHGTVMKINQERAEELQEAERFS-RKAAQA 1032
Query: 577 KNELIE---DVELLKKESNSQIKFLREEVEKKRV 607
+L ++ELL+ + + R E+EK V
Sbjct: 1033 ARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV 1066
Score = 50.0 bits (114), Expect = 3e-05
Identities = 99/511 (19%), Positives = 210/511 (41%), Gaps = 29/511 (5%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEK-LTSNELTLAETQ 253
MR+ + EK+ E L + + D E SLE EV + ++ K Q+K + T+
Sbjct: 1345 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 1404
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKT--KLDEEKQAIISKCKVDQENLKTKHN 311
+E HH ++ E I + L+ +L E ++ +S K +N K
Sbjct: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
Query: 312 ASIESL-KNQMLKEKCEALEQLHSQLIIK-EQEMKAKLEQIEESASEKLKICEIQFEERS 369
+ SL + + E+ E Q + ++K +Q++++ ++ K+K EI E
Sbjct: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINK 1524
Query: 370 QSIQEHCSQQ--EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q K + L +E+++L+ +++ Q L + E
Sbjct: 1525 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1584
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
++ + + E+ ++K +L+L ++ K + +L + V +RE
Sbjct: 1585 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Query: 488 SDSELEQLEDQ-----VQMLTSAKE--VLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
S LE+L Q VQ+ + +++ E+ + L +R+ ++K L NIL
Sbjct: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD- 1703
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLR 599
L E+ + + + + +EK ++ ++ +L +E+++ + ++ +I++ +
Sbjct: 1704 --MLQLENHELQGLKLQHDQRVSELEK---TQVAVLEEKLELENLQQISQQQKGEIEWQK 1758
Query: 600 EEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLV 658
+ +E+ KR + M L++ DL + E+ +
Sbjct: 1759 QLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1813
Query: 659 VELSLLRQEN-EELTMTVAKQSSIIDKLKKD 688
E S + Q N E+L + V K +D+L +D
Sbjct: 1814 EENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/320 (20%), Positives = 136/320 (42%), Gaps = 21/320 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E K Q + +IE+ K ++ Q + + + L + + ++ +++ K + ++
Sbjct: 1921 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1980
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
T+ + KV A +R+ + E E+ CE+L+ + + +LS E+ + +
Sbjct: 1981 EL--TDQKSKLDQVLSKVLAAEERVRT-LQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 232 DSLCKDLQEKLTSN--ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD 289
LQ++ S + +L Q E K +A S++ KI+ L+ L
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA-----SLKEALKIQRSQLEKNLL 2092
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E+KQ + + K A+IE L Q E+ L + +Q+ + E+K ++
Sbjct: 2093 EQKQ---------ENSCIQKEMATIE-LVAQDNHERARRLMKELNQMQYEYTELKKQMAN 2142
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
++ +++I + +S+ E + + Q+L + +L+ L+ N +L+
Sbjct: 2143 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 2202
Query: 410 ELNNLKNCKDE-LSTEKFNF 428
NL +E EK NF
Sbjct: 2203 LKENLPFTMNEGPFEEKLNF 2222
Score = 42.7 bits (96), Expect = 0.004
Identities = 86/457 (18%), Positives = 199/457 (43%), Gaps = 36/457 (7%)
Query: 151 SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD----AEKVSAMINDMRSRIIELEKK 206
S+N I E KL KLR N + + + + ++G + +K++ N++ + L KK
Sbjct: 133 SYNLIGKIEKLDKLLKLRELNLS-YNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKK 191
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK-LTSNELTLAETQQRLEMVKGHHAL 265
++L + K ++SSL+++ ++ +DL L N + + +
Sbjct: 192 LKSL-RVLNLKGNKISSLQDISKLKP--LQDLISLILVENPVVTLPHYLQFTIFHLRSLE 248
Query: 266 ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
+LE ++ + E + E + + K ++ E LK+K +E +KNQ K
Sbjct: 249 SLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNK 308
Query: 326 C---EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT 382
EA+ Q S +K ++ K E +++ E + C+ Q+E + + +
Sbjct: 309 SLKEEAMLQKQSCEELK-SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+ Y E E+ ++ D + + ++ +TE + I+ + ++ + +E
Sbjct: 368 LNYYPSEYAEI--------DKAPDESPYIGKSRYKRNMFATESY-IIDSAQAVQIKKMEP 418
Query: 443 TINYENEKNKL--NLAVEKAIKEKNK----FETSLSVTRDIVHVLTLRLRESDSELEQLE 496
N+ L + ++ +++K K +T LS D + ++ + E +QLE
Sbjct: 419 DEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE 478
Query: 497 DQVQM---LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ +Q+ + K++L +L+ + L N +R+ E + + + K K + + I +
Sbjct: 479 EAIQLKKISEAGKDLLYKQLSG-RLQLVNKLRQ--EALDLELQMEKQKQEIAGKQKEIKD 535
Query: 554 HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+ I+SL + + + + + K+ + ++++ K+
Sbjct: 536 LQIA-IDSLDSKDPK-HSHMKAQKSGKEQQLDIMNKQ 570
>AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein.
Length = 1793
Score = 77.4 bits (182), Expect = 2e-13
Identities = 104/576 (18%), Positives = 242/576 (42%), Gaps = 33/576 (5%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ + N I +++ +L+EL+ F++ N+ +E +L+ ++ ++ +
Sbjct: 1102 EVTEKCNHIREVKSLLEELS--FQKGELNVQISERKTQLTLIK----------QEIE-KE 1148
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ-MELSSLEEVITVRDSLCKDLQEKLTS 244
E + ++ M EL+ + L E ++ Q ++L + V + + L+EKL
Sbjct: 1149 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1208
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIE-LEALKTKLDEEKQAIISKCKVDQ 303
L QQ+ E+ L + E R + L++ L +EK+ + KC + +
Sbjct: 1209 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1268
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ L + +N +++ LE+L + +QE+ +L + + S + +
Sbjct: 1269 KKLAQTKRVLAAAEENSKMEQS--NLEKLELNVRKLQQELD-QLNRDKLSLHNDISAMQQ 1325
Query: 364 QFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
Q +E+ + S+QE + + + +Q++ D+ ++ + L+++++ N ++
Sbjct: 1326 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1385
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
E+ ++++ L++E+ E + ++ ++ E++K ETS ++ H
Sbjct: 1386 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 1445
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNI 537
L L + S+L+Q+ +V L+ E + + TL+ T R+ E ++ LV
Sbjct: 1446 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 1505
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF 597
AL KE + L K+A +++ ++K L ++ + E N
Sbjct: 1506 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL--KIQRSQLEKN----L 1559
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL--LAQAAADLSRLENENERYXXXXXXXX 655
L ++ E + EM R++ L Q + + L+ +
Sbjct: 1560 LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQM 1619
Query: 656 SLVVELSLLRQE-NEELTMTVAKQSSIIDKLKKDLE 690
+ + L+ E +E+ ++ + + +L DLE
Sbjct: 1620 EISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 1655
Score = 62.1 bits (144), Expect = 7e-09
Identities = 86/406 (21%), Positives = 170/406 (41%), Gaps = 21/406 (5%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINN 171
R ++ + E + I+D E L+ ++EL ++ DF ++ +++L I
Sbjct: 818 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK 877
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITV 230
+ H E + E + + RS + E ++ ++E+ K+ +++E+
Sbjct: 878 SLKHHEDIV---DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 934
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL-ALEANESIRREYKIELEALKTKLD 289
+ SL LQ + + EL + + +VK L +L+A+ ++KI+ E + L
Sbjct: 935 KRSL---LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI---LK 988
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E + + +K Q K K + E K Q E E E H Q ++KE E+ L Q
Sbjct: 989 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ-VLKESEV---LLQ 1044
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTLDLTNNQNS 405
+ + EKLK ++ + +++ + L+ Q +L+ L L + +
Sbjct: 1045 AKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1104
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+ + +K+ +ELS +K +I K +L E E+ L + + + K K
Sbjct: 1105 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1164
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+ + L + + H L + D + +LE + K LEN
Sbjct: 1165 ELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1210
Score = 58.0 bits (134), Expect = 1e-07
Identities = 102/514 (19%), Positives = 219/514 (42%), Gaps = 45/514 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
E + +D+E + + I +D + I+ LQE L + + Q+ N +++
Sbjct: 62 ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKE 121
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
R+ + + DAE + + ++ S + E + +L D +
Sbjct: 122 TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAE 181
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LE + +RD+ L+E+L E RL ++ +++ E + E +A
Sbjct: 182 LEARLNLRDAEANQLKEEL--------EKVTRLTQLE---------QSALQAELEKERQA 224
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK L + + + + + + + K KH +L Q LK+ L + L ++ +E+
Sbjct: 225 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEV 283
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A+++++ KL E+ S + + + +K Q+ E + K+ D +
Sbjct: 284 AARVDELRRKL--KLGTGEMNIHSPSDVLGKSLADLQK--QFSE-ILARSKWERDEAQVR 338
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
L++E+ L+ +++L+T + EE + + +E +N++ +++ +++ E
Sbjct: 339 ERKLQEEM-ALQ--QEKLATGQ----EEFRQACERALEARMNFDKRQHEAR--IQQMENE 389
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-------LTTY 516
+ + +L +I + L+L+E+D E E++ Q++ L K++ + + L
Sbjct: 390 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 449
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
L V D+ A + I K + L H +M+ N E LQ E+ + R+
Sbjct: 450 LKKLKKAVATSDKLATAELTIAKDQ--LKSLHGTVMKINQERAEELQEAERFS-RKAAQA 506
Query: 577 KNELIE---DVELLKKESNSQIKFLREEVEKKRV 607
+L ++ELL+ + + R E+EK V
Sbjct: 507 ARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV 540
Score = 50.0 bits (114), Expect = 3e-05
Identities = 99/511 (19%), Positives = 210/511 (41%), Gaps = 29/511 (5%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEK-LTSNELTLAETQ 253
MR+ + EK+ E L + + D E SLE EV + ++ K Q+K + T+
Sbjct: 813 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 872
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKT--KLDEEKQAIISKCKVDQENLKTKHN 311
+E HH ++ E I + L+ +L E ++ +S K +N K
Sbjct: 873 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 932
Query: 312 ASIESL-KNQMLKEKCEALEQLHSQLIIK-EQEMKAKLEQIEESASEKLKICEIQFEERS 369
+ SL + + E+ E Q + ++K +Q++++ ++ K+K EI E
Sbjct: 933 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINK 992
Query: 370 QSIQEHCSQQ--EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q K + L +E+++L+ +++ Q L + E
Sbjct: 993 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1052
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
++ + + E+ ++K +L+L ++ K + +L + V +RE
Sbjct: 1053 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1112
Query: 488 SDSELEQLEDQ-----VQMLTSAKE--VLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
S LE+L Q VQ+ + +++ E+ + L +R+ ++K L NIL
Sbjct: 1113 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD- 1171
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLR 599
L E+ + + + + +EK ++ ++ +L +E+++ + ++ +I++ +
Sbjct: 1172 --MLQLENHELQGLKLQHDQRVSELEK---TQVAVLEEKLELENLQQISQQQKGEIEWQK 1226
Query: 600 EEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLV 658
+ +E+ KR + M L++ DL + E+ +
Sbjct: 1227 QLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1281
Query: 659 VELSLLRQEN-EELTMTVAKQSSIIDKLKKD 688
E S + Q N E+L + V K +D+L +D
Sbjct: 1282 EENSKMEQSNLEKLELNVRKLQQELDQLNRD 1312
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/320 (20%), Positives = 136/320 (42%), Gaps = 21/320 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E K Q + +IE+ K ++ Q + + + L + + ++ +++ K + ++
Sbjct: 1389 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1448
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
T+ + KV A +R+ + E E+ CE+L+ + + +LS E+ + +
Sbjct: 1449 EL--TDQKSKLDQVLSKVLAAEERVRT-LQEEERWCESLEKTLSQTKRQLSEREQQLVEK 1505
Query: 232 DSLCKDLQEKLTSN--ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD 289
LQ++ S + +L Q E K +A S++ KI+ L+ L
Sbjct: 1506 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA-----SLKEALKIQRSQLEKNLL 1560
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E+KQ + + K A+IE L Q E+ L + +Q+ + E+K ++
Sbjct: 1561 EQKQ---------ENSCIQKEMATIE-LVAQDNHERARRLMKELNQMQYEYTELKKQMAN 1610
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
++ +++I + +S+ E + + Q+L + +L+ L+ N +L+
Sbjct: 1611 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 1670
Query: 410 ELNNLKNCKDE-LSTEKFNF 428
NL +E EK NF
Sbjct: 1671 LKENLPFTMNEGPFEEKLNF 1690
Score = 37.5 bits (83), Expect = 0.17
Identities = 59/278 (21%), Positives = 119/278 (42%), Gaps = 25/278 (8%)
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL------IIKE 340
K E K I+ +D ++ K H + +S K Q L + +QL S+L I KE
Sbjct: 3 KQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 62
Query: 341 -QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
+E+K EQ+ E + + E +QE+ + + E ++L+
Sbjct: 63 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR----- 117
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++ L Q L ++ +D+L + + ++ EL E + E++++N ++++
Sbjct: 118 --DEKETLLQRLTEVEQERDQLEIVAM----DAENMRKELAELESALQ-EQHEVNASLQQ 170
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV-LENELTTYKN 518
+ + +E L ++ +L+E ELE++ Q+ SA + LE E KN
Sbjct: 171 TQGDLSAYEAELEARLNLRDAEANQLKE---ELEKVTRLTQLEQSALQAELEKERQALKN 227
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
L + E KE + L +K ++ +++ +
Sbjct: 228 ALGKA--QFSEEKEQENSELHAKLKHLQDDNNLLKQQL 263
>AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 1186 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 1236
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 1292
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 1349
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Score = 72.5 bits (170), Expect = 5e-12
Identities = 126/638 (19%), Positives = 259/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 1067
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 1068 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 1126
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G + +E N+ E+ K+ +
Sbjct: 1127 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSCQIEMNKKREAEFQKMRRDLE 1179
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 1295
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1416 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1532 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDL 1178
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 1179 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 1231
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 1290
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 1349
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Score = 66.5 bits (155), Expect = 3e-10
Identities = 134/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 946
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEEKQAIISK 298
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + + + +
Sbjct: 1007 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK-LTQE 1064
Query: 299 CKVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESAS- 355
+D EN K + + ++ ++ L + E + L SQL K +E++A++E++EE
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 356 --------EKLKI-CEIQFEERSQSIQE-----HC-----SQQEKTIQYLEQEIKELKYT 396
EKL+ + EE S+ ++E C ++E Q + ++++E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 1243
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 1244 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 1296
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 1297 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 1352
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1413 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1465
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 894 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 944
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 945 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 1064 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLE 1179
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 1180 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 1231
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1458
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1459 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1572
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1630
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1869
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1870 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1905
>AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein.
Length = 2325
Score = 77.4 bits (182), Expect = 2e-13
Identities = 104/576 (18%), Positives = 242/576 (42%), Gaps = 33/576 (5%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ + N I +++ +L+EL+ F++ N+ +E +L+ ++ ++ +
Sbjct: 1634 EVTEKCNHIREVKSLLEELS--FQKGELNVQISERKTQLTLIK----------QEIE-KE 1680
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ-MELSSLEEVITVRDSLCKDLQEKLTS 244
E + ++ M EL+ + L E ++ Q ++L + V + + L+EKL
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIE-LEALKTKLDEEKQAIISKCKVDQ 303
L QQ+ E+ L + E R + L++ L +EK+ + KC + +
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 1800
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ L + +N +++ LE+L + +QE+ +L + + S + +
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQS--NLEKLELNVRKLQQELD-QLNRDKLSLHNDISAMQQ 1857
Query: 364 QFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
Q +E+ + S+QE + + + +Q++ D+ ++ + L+++++ N ++
Sbjct: 1858 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1917
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
E+ ++++ L++E+ E + ++ ++ E++K ETS ++ H
Sbjct: 1918 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 1977
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNI 537
L L + S+L+Q+ +V L+ E + + TL+ T R+ E ++ LV
Sbjct: 1978 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF 597
AL KE + L K+A +++ ++K L ++ + E N
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL--KIQRSQLEKN----L 2091
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL--LAQAAADLSRLENENERYXXXXXXXX 655
L ++ E + EM R++ L Q + + L+ +
Sbjct: 2092 LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQM 2151
Query: 656 SLVVELSLLRQE-NEELTMTVAKQSSIIDKLKKDLE 690
+ + L+ E +E+ ++ + + +L DLE
Sbjct: 2152 EISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 2187
Score = 62.1 bits (144), Expect = 7e-09
Identities = 86/406 (21%), Positives = 170/406 (41%), Gaps = 21/406 (5%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINN 171
R ++ + E + I+D E L+ ++EL ++ DF ++ +++L I
Sbjct: 1350 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK 1409
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITV 230
+ H E + E + + RS + E ++ ++E+ K+ +++E+
Sbjct: 1410 SLKHHEDIV---DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 1466
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL-ALEANESIRREYKIELEALKTKLD 289
+ SL LQ + + EL + + +VK L +L+A+ ++KI+ E + L
Sbjct: 1467 KRSL---LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI---LK 1520
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E + + +K Q K K + E K Q E E E H Q ++KE E+ L Q
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ-VLKESEV---LLQ 1576
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTLDLTNNQNS 405
+ + EKLK ++ + +++ + L+ Q +L+ L L + +
Sbjct: 1577 AKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 1636
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+ + +K+ +ELS +K +I K +L E E+ L + + + K K
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1696
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+ + L + + H L + D + +LE + K LEN
Sbjct: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742
Score = 60.5 bits (140), Expect = 2e-08
Identities = 86/400 (21%), Positives = 173/400 (43%), Gaps = 28/400 (7%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQ----DVEIRNKDQTICEY---NKQIEDYKNEIAQLQ 138
S K+ + ++ I+ + VQ + D ++RN + + + Q+ED + +I+ Q
Sbjct: 391 SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
Query: 139 EILKELATKFRQSHNNI-----DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMI 193
L EL + ++ I +F +++ + +I+ + + G ++
Sbjct: 451 TRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGR-----LQLV 505
Query: 194 NDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQ 253
N +R ++LE + E E+ KQ E+ L+ I DS KD + + + E Q
Sbjct: 506 NKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS--KDPKHSHMKAQKSGKEQQ 563
Query: 254 QRLEMVKGHHALALEANESIRREYK--IELEALKTKLDEEKQAIISKCKVDQENLKTKHN 311
+ M K + L +E + R K E++ L+ +L E + A K D E + +
Sbjct: 564 LDI-MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQ 622
Query: 312 ASIESLKNQ--MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESA--SEKLKICEIQFEE 367
+ ++K Q + +C L L+ + E++ + +Q+E A +E ++ + E
Sbjct: 623 EYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES 682
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD-ELSTEKF 426
Q E + ++T L EL+ L+L + + + LK+EL + E S +
Sbjct: 683 ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQA 742
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNL-AVEKAIKEKN 465
+E + LK+ L + + E E+ L A K +++ N
Sbjct: 743 ELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
Score = 58.0 bits (134), Expect = 1e-07
Identities = 102/514 (19%), Positives = 219/514 (42%), Gaps = 45/514 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
E + +D+E + + I +D + I+ LQE L + + Q+ N +++
Sbjct: 588 ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKE 647
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
R+ + + DAE + + ++ S + E + +L D +
Sbjct: 648 TLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAE 707
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
LE + +RD+ L+E+L E RL ++ +++ E + E +A
Sbjct: 708 LEARLNLRDAEANQLKEEL--------EKVTRLTQLE---------QSALQAELEKERQA 750
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK L + + + + + + + K KH +L Q LK+ L + L ++ +E+
Sbjct: 751 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL-VRPEEV 809
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
A+++++ KL E+ S + + + +K Q+ E + K+ D +
Sbjct: 810 AARVDELRRKL--KLGTGEMNIHSPSDVLGKSLADLQK--QFSE-ILARSKWERDEAQVR 864
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
L++E+ L+ +++L+T + EE + + +E +N++ +++ +++ E
Sbjct: 865 ERKLQEEM-ALQ--QEKLATGQ----EEFRQACERALEARMNFDKRQHEAR--IQQMENE 915
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-------LTTY 516
+ + +L +I + L+L+E+D E E++ Q++ L K++ + + L
Sbjct: 916 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
L V D+ A + I K + L H +M+ N E LQ E+ + R+
Sbjct: 976 LKKLKKAVATSDKLATAELTIAKDQ--LKSLHGTVMKINQERAEELQEAERFS-RKAAQA 1032
Query: 577 KNELIE---DVELLKKESNSQIKFLREEVEKKRV 607
+L ++ELL+ + + R E+EK V
Sbjct: 1033 ARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV 1066
Score = 50.0 bits (114), Expect = 3e-05
Identities = 99/511 (19%), Positives = 210/511 (41%), Gaps = 29/511 (5%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEK-LTSNELTLAETQ 253
MR+ + EK+ E L + + D E SLE EV + ++ K Q+K + T+
Sbjct: 1345 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 1404
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKT--KLDEEKQAIISKCKVDQENLKTKHN 311
+E HH ++ E I + L+ +L E ++ +S K +N K
Sbjct: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
Query: 312 ASIESL-KNQMLKEKCEALEQLHSQLIIK-EQEMKAKLEQIEESASEKLKICEIQFEERS 369
+ SL + + E+ E Q + ++K +Q++++ ++ K+K EI E
Sbjct: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINK 1524
Query: 370 QSIQEHCSQQ--EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q K + L +E+++L+ +++ Q L + E
Sbjct: 1525 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1584
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
++ + + E+ ++K +L+L ++ K + +L + V +RE
Sbjct: 1585 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Query: 488 SDSELEQLEDQ-----VQMLTSAKE--VLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
S LE+L Q VQ+ + +++ E+ + L +R+ ++K L NIL
Sbjct: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILD- 1703
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLR 599
L E+ + + + + +EK ++ ++ +L +E+++ + ++ +I++ +
Sbjct: 1704 --MLQLENHELQGLKLQHDQRVSELEK---TQVAVLEEKLELENLQQISQQQKGEIEWQK 1758
Query: 600 EEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLV 658
+ +E+ KR + M L++ DL + E+ +
Sbjct: 1759 QLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 1813
Query: 659 VELSLLRQEN-EELTMTVAKQSSIIDKLKKD 688
E S + Q N E+L + V K +D+L +D
Sbjct: 1814 EENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/320 (20%), Positives = 136/320 (42%), Gaps = 21/320 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E K Q + +IE+ K ++ Q + + + L + + ++ +++ K + ++
Sbjct: 1921 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 1980
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
T+ + KV A +R+ + E E+ CE+L+ + + +LS E+ + +
Sbjct: 1981 EL--TDQKSKLDQVLSKVLAAEERVRT-LQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 232 DSLCKDLQEKLTSN--ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD 289
LQ++ S + +L Q E K +A S++ KI+ L+ L
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA-----SLKEALKIQRSQLEKNLL 2092
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E+KQ + + K A+IE L Q E+ L + +Q+ + E+K ++
Sbjct: 2093 EQKQ---------ENSCIQKEMATIE-LVAQDNHERARRLMKELNQMQYEYTELKKQMAN 2142
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
++ +++I + +S+ E + + Q+L + +L+ L+ N +L+
Sbjct: 2143 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 2202
Query: 410 ELNNLKNCKDE-LSTEKFNF 428
NL +E EK NF
Sbjct: 2203 LKENLPFTMNEGPFEEKLNF 2222
Score = 42.7 bits (96), Expect = 0.004
Identities = 86/457 (18%), Positives = 199/457 (43%), Gaps = 36/457 (7%)
Query: 151 SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD----AEKVSAMINDMRSRIIELEKK 206
S+N I E KL KLR N + + + + ++G + +K++ N++ + L KK
Sbjct: 133 SYNLIGKIEKLDKLLKLRELNLS-YNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKK 191
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK-LTSNELTLAETQQRLEMVKGHHAL 265
++L + K ++SSL+++ ++ +DL L N + + +
Sbjct: 192 LKSL-RVLNLKGNKISSLQDISKLKP--LQDLISLILVENPVVTLPHYLQFTIFHLRSLE 248
Query: 266 ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK 325
+LE ++ + E + E + + K ++ E LK+K +E +KNQ K
Sbjct: 249 SLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNK 308
Query: 326 C---EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT 382
EA+ Q S +K ++ K E +++ E + C+ Q+E + + +
Sbjct: 309 SLKEEAMLQKQSCEELK-SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+ Y E E+ ++ D + + ++ +TE + I+ + ++ + +E
Sbjct: 368 LNYYPSEYAEI--------DKAPDESPYIGKSRYKRNMFATESY-IIDSAQAVQIKKMEP 418
Query: 443 TINYENEKNKL--NLAVEKAIKEKNK----FETSLSVTRDIVHVLTLRLRESDSELEQLE 496
N+ L + ++ +++K K +T LS D + ++ + E +QLE
Sbjct: 419 DEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE 478
Query: 497 DQVQM---LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ +Q+ + K++L +L+ + L N +R+ E + + + K K + + I +
Sbjct: 479 EAIQLKKISEAGKDLLYKQLSG-RLQLVNKLRQ--EALDLELQMEKQKQEIAGKQKEIKD 535
Query: 554 HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+ I+SL + + + + + K+ + ++++ K+
Sbjct: 536 LQIA-IDSLDSKDPK-HSHMKAQKSGKEQQLDIMNKQ 570
>AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-1
protein.
Length = 795
Score = 77.4 bits (182), Expect = 2e-13
Identities = 121/556 (21%), Positives = 251/556 (45%), Gaps = 28/556 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQT--ICEYNKQIEDYKNEIAQ 136
KI +A +I++ + L +E +Q I+ + T +C K+ E +
Sbjct: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
Query: 137 LQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
E +E + NN + ++ +LR+ N E + D EK+ + +
Sbjct: 199 KYEYEREETRQVYMDLNN-NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNELTLA-ETQ 253
+ I + EK+ L ++ +K+ ++ L ++ L+E KL S L + E Q
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 254 QRLEMVKGHHALALEANESIRREYKIELE-ALKT--KLDEEKQAII---SKCKVDQENLK 307
L ++L+ + S ++ + +L+ A KT +L EEK+ + +K + +
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
T+ ++ SL+ ++L+ + + LE+ QL I E++ K ++EE ++ E++ EE
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-MTKLTNNKEVELEE 435
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ + E + + Q+ E+ +ELK T ++E+++L+ ++T +
Sbjct: 436 LKKVLGEKETLLYENKQF-EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 428 FIEEIKTLKDEL-IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH---VL 481
+ +E+K LK EL EK N E + NKL+L ++ +E + L ++ ++
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 482 TLRLRESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
R+ + L++ E Q++ L +E L+ + K L+ + C+ ++ + N K
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVELLKKE-SNSQI- 595
L +E+ + + + L E + + EL + K + E + +KE + +I
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 596 -KFLREEVEKKRVLCE 610
+ L EEVEK +V+ +
Sbjct: 675 EENLLEEVEKAKVIAD 690
Score = 72.5 bits (170), Expect = 5e-12
Identities = 113/517 (21%), Positives = 229/517 (44%), Gaps = 40/517 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQ----EILKELATKFRQSHNNIDFNEIDRKLS 165
+ E+R K+ + E K IE + I +LQ ++ +L +++ + I N R L
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL---- 221
L E + E+ + D+ + I ++ E L + + ++E+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKL 243
Query: 222 -SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR-EYKI 279
E++ + K++ +K L L + ++ +K L E+ + + + E K
Sbjct: 244 KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+L++ K EKQ ++K + E++K S+ + K L+E + + QL +
Sbjct: 304 KLQSENLKQSIEKQHHLTK---ELEDIKVSLQRSVSTQK--ALEEDLQIATKTICQL-TE 357
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E+E + + E + A+ + E FE S++E +++ ++ E ++K L T++L
Sbjct: 358 EKETQME-ESNKARAAHSFVVTE--FETTVCSLEELLRTEQQRLEKNEDQLKIL--TMEL 412
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++S+L +E+ L N K+ E +EE+K + E ++T+ YEN+ + E+
Sbjct: 413 -QKKSSEL-EEMTKLTNNKE---VE----LEELKKVLGE--KETLLYENK--QFEKIAEE 459
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS--AKEVLEN-ELTTY 516
+ + L VH L ++L + + +V+ L + E L+N ELT++
Sbjct: 460 LKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
N L+ +E + + LK++ + + E + IE+LQ E + EL +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 577 KNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ EL ++V+ +S LR++VE K E
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Score = 68.9 bits (161), Expect = 6e-11
Identities = 111/528 (21%), Positives = 228/528 (43%), Gaps = 43/528 (8%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
++K+ +E + Q ++ + K++ED K + + K L + + I
Sbjct: 293 RDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTI 352
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK---KCEALDN 212
+ K +++ +N H+ V V ++ +R+ LEK + + L
Sbjct: 353 -CQLTEEKETQMEESN-KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR---LEMVKGHHALA--- 266
E+ K EL + ++ ++ ++L++ L E L E +Q E +KG
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
L+A E + +I+L A+ T ++ + K + EN E LKN L C
Sbjct: 471 LQAREKEVHDLEIQLTAITTS-EQYYSKEVKDLKTELEN---------EKLKNTELTSHC 520
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
L + +L + +M +L+ +E + K E + ++ +++QE +Q ++Y+
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-EERMLKQIENLQETETQLRNELEYV 579
Query: 387 EQEIK----ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+E+K E+K LD + ++L++++ N +EL E + +K K K
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN----KALKK-KGTAESK 634
Query: 443 TIN-YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+N YE + NKL L +E A K KF +T + + ++ LE++E + ++
Sbjct: 635 QLNVYEIKVNKLELELESA---KQKFG---EITDTYQKEIEDKKISEENLLEEVE-KAKV 687
Query: 502 LTSAKEVLENELTTY-KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ L+ E+ ++ + V +++K I++ + + + + +L
Sbjct: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRA 747
Query: 561 SLQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKK 605
SL+ EL ++K +L E+ E LK+E+ L+E+ +KK
Sbjct: 748 SLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKKKK 795
Score = 52.0 bits (119), Expect = 7e-06
Identities = 94/418 (22%), Positives = 176/418 (42%), Gaps = 36/418 (8%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK+ L E E L +++S+L KE E K+++ + S +L+ E + +E + I+
Sbjct: 89 EGLKDSDL-ENSEGLSRVYSKLY-KEAE---KIKKWKVSTEAELRQKESKLQENRKIIEA 143
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q K IQ L+ +++ L+ +N DL +E N ++ + L E+ K
Sbjct: 144 ----QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E E Y + LN +EK I + +R +H +L+E +++
Sbjct: 200 YEYEREETRQVYMD----LNNNIEKMITAFEELRVQAENSRLEMH---FKLKEDYEKIQH 252
Query: 495 LEDQVQMLTSAKE----VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE + + + KE +L ++T +N + + +E ++ VN L+ K L E+ +
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK-VNQLEEKTKLQSENLK 311
Query: 551 -IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+E L + L++++ R + T K L ED+++ K I L EE E +
Sbjct: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKT----ICQLTEEKETQMEES 366
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
+ L + L E +R L +EL E E
Sbjct: 367 NKARAAHSFVVTEFETTVCSLEEL------LRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 670 ELTMTVAKQSSIIDKLKKDLEQSQ---YTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
E+T + +++LKK L + + Y K + + LK ++ + + RE+ +
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
>AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated
protein CEP110 protein.
Length = 994
Score = 77.4 bits (182), Expect = 2e-13
Identities = 104/576 (18%), Positives = 242/576 (42%), Gaps = 33/576 (5%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ + N I +++ +L+EL+ F++ N+ +E +L+ ++ ++ +
Sbjct: 303 EVTEKCNHIREVKSLLEELS--FQKGELNVQISERKTQLTLIK----------QEIE-KE 349
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ-MELSSLEEVITVRDSLCKDLQEKLTS 244
E + ++ M EL+ + L E ++ Q ++L + V + + L+EKL
Sbjct: 350 EENLQVVLRQMSKHKTELQNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 409
Query: 245 NELTLAETQQRLEMVKGHHALALEANESIRREYKIE-LEALKTKLDEEKQAIISKCKVDQ 303
L QQ+ E+ L + E R + L++ L +EK+ + KC + +
Sbjct: 410 ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE 469
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ L + +N +++ LE+L + +QE+ +L + + S + +
Sbjct: 470 KKLAQTKRVLAAAEENSKMEQS--NLEKLDLNVRKLQQELD-QLNRDKLSLHNDISAMQQ 526
Query: 364 QFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
Q +E+ + S+QE + + + +Q++ D+ ++ + L+++++ N ++
Sbjct: 527 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 586
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
E+ ++++ L++E+ E + ++ ++ E++K ETS ++ H
Sbjct: 587 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 646
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNI 537
L L + S+L+Q+ +V L+ E + + TL+ T R+ E ++ LV
Sbjct: 647 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 706
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF 597
AL KE + L K+A +++ ++K L ++ + E N
Sbjct: 707 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL--KIQRSQLEKN----L 760
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL--LAQAAADLSRLENENERYXXXXXXXX 655
L ++ E + EM R++ L Q + + L+ +
Sbjct: 761 LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQM 820
Query: 656 SLVVELSLLRQE-NEELTMTVAKQSSIIDKLKKDLE 690
+ + L+ E +E+ ++ + + +L DLE
Sbjct: 821 EISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLE 856
Score = 62.5 bits (145), Expect = 5e-09
Identities = 86/406 (21%), Positives = 170/406 (41%), Gaps = 21/406 (5%)
Query: 114 RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF--NEIDRKLSKLRINN 171
R ++ + E + I+D E L+ ++EL ++ DF ++ +++L I
Sbjct: 19 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQRQKDFIDGNVESLMTELEIEK 78
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY-DKQMELSSLEEVITV 230
+ H E + E + + RS + E ++ ++E+ K+ +++E+
Sbjct: 79 SLKHHEDIV---DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 135
Query: 231 RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL-ALEANESIRREYKIELEALKTKLD 289
+ SL LQ + + EL + + +VK L +L+A+ ++KI+ E + L
Sbjct: 136 KRSL---LQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEI---LK 189
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E + + +K Q K K + E K Q E E E H Q ++KE E+ L Q
Sbjct: 190 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ-VLKESEV---LLQ 245
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE----QEIKELKYTLDLTNNQNS 405
+ + EKLK ++ + +++ + L+ Q +L+ L L + +
Sbjct: 246 AKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT 305
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+ + +K+ +ELS +K +I K +L E E+ L + + + K K
Sbjct: 306 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 365
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+ + L + + H L + D + +LE + K LEN
Sbjct: 366 ELQNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 411
Score = 48.4 bits (110), Expect = 9e-05
Identities = 98/511 (19%), Positives = 210/511 (41%), Gaps = 29/511 (5%)
Query: 196 MRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEK-LTSNELTLAETQ 253
MR+ + EK+ E L + + D E SLE EV + ++ K ++K + T+
Sbjct: 14 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQRQKDFIDGNVESLMTE 73
Query: 254 QRLEMVKGHHALALEANESIRREYKIELEALKT--KLDEEKQAIISKCKVDQENLKTKHN 311
+E HH ++ E I + L+ +L E ++ +S K +N K
Sbjct: 74 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 133
Query: 312 ASIESL-KNQMLKEKCEALEQLHSQLIIK-EQEMKAKLEQIEESASEKLKICEIQFEERS 369
+ SL + + E+ E Q + ++K +Q++++ ++ K+K EI E
Sbjct: 134 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINK 193
Query: 370 QSIQEHCSQQ--EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q K + L +E+++L+ +++ Q L + E
Sbjct: 194 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 253
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
++ + + E+ ++K +L+L ++ K + +L + V +RE
Sbjct: 254 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 313
Query: 488 SDSELEQLEDQ-----VQMLTSAKE--VLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
S LE+L Q VQ+ + +++ E+ + L +R+ ++K L NIL
Sbjct: 314 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELQNILD- 372
Query: 541 KAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLR 599
L E+ + + + + +EK ++ ++ +L +E+++ + ++ +I++ +
Sbjct: 373 --MLQLENHELQGLKLQHDQRVSELEK---TQVAVLEEKLELENLQQISQQQKGEIEWQK 427
Query: 600 EEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLV 658
+ +E+ KR + M L++ DL + E+ +
Sbjct: 428 QLLERDKREIERMTAESRALQSCVE-----CLSKEKEDLQEKCDIWEKKLAQTKRVLAAA 482
Query: 659 VELSLLRQEN-EELTMTVAKQSSIIDKLKKD 688
E S + Q N E+L + V K +D+L +D
Sbjct: 483 EENSKMEQSNLEKLDLNVRKLQQELDQLNRD 513
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/320 (20%), Positives = 136/320 (42%), Gaps = 21/320 (6%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E K Q + +IE+ K ++ Q + + + L + + ++ +++ K + ++
Sbjct: 590 EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK 649
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
T+ + KV A +R+ + E E+ CE+L+ + + +LS E+ + +
Sbjct: 650 EL--TDQKSKLDQVLSKVLAAEERVRT-LQEEERWCESLEKTLSQTKRQLSEREQQLVEK 706
Query: 232 DSLCKDLQEKLTSN--ELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD 289
LQ++ S + +L Q E K +A S++ KI+ L+ L
Sbjct: 707 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA-----SLKEALKIQRSQLEKNLL 761
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E+KQ + + K A+IE L Q E+ L + +Q+ + E+K ++
Sbjct: 762 EQKQ---------ENSCIQKEMATIE-LVAQDNHERARRLMKELNQMQYEYTELKKQMAN 811
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
++ +++I + +S+ E + + Q+L + +L+ L+ N +L+
Sbjct: 812 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 871
Query: 410 ELNNLKNCKDE-LSTEKFNF 428
NL +E EK NF
Sbjct: 872 LKENLPFTMNEGPFEEKLNF 891
>AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypeptide 7,
cardiac muscle, beta variant protein.
Length = 1574
Score = 77.4 bits (182), Expect = 2e-13
Identities = 79/349 (22%), Positives = 153/349 (43%), Gaps = 25/349 (7%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
I++LE + LD + K EL++L I +L LQ+KL + + E ++ LE
Sbjct: 705 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 764
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A + + RE + E L + +++++++A K + D E +H
Sbjct: 765 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 824
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + KL++ ++ +
Sbjct: 825 EATAAALR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEFKLELDDV--TSNME 875
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
I + + EK + LE ++ E + + T +DL + L+ ELS + ++
Sbjct: 876 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ----LD 931
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E + L +L + Y + L +E+ +K KN +L R H L + +
Sbjct: 932 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLREQYEE 988
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILK 539
E E + ++L+ A + T Y+ E +E K+ L L+
Sbjct: 989 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1037
Score = 73.3 bits (172), Expect = 3e-12
Identities = 126/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 649 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 706
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 707 DLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 765
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 766 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 818
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 819 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 878
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 879 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 934
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 935 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 994
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 995 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1054
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1055 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1110
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 1111 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1170
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1171 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1227
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 1228 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1265
Score = 72.5 bits (170), Expect = 5e-12
Identities = 116/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q D ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 698 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 757
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 758 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 817
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 818 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 870
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 871 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 929
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 930 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 988
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 989 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1048
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 1049 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1108
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 1109 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1168
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 1169 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1226
Score = 67.3 bits (157), Expect = 2e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 529 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 585
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 586 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 645
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 646 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 704
Query: 296 ISKCKVDQ----ENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D+ E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 705 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EA 763
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 764 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 823
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 824 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 882
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 883 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 935
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 936 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 991
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 992 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1051
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 1052 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 1104
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 1105 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1141
Score = 66.1 bits (154), Expect = 4e-10
Identities = 85/414 (20%), Positives = 185/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 474 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 532
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 533 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 583
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 584 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 642
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 643 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 702
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L+ ++K E N + + + L +L+E + +E+LE
Sbjct: 703 ESIMD----LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 758
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 759 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 818
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 819 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 870
Score = 63.7 bits (148), Expect = 2e-09
Identities = 83/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 479 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 537
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 538 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 576
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 577 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 636
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 637 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 692
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ L+ L N LN + + L LK A
Sbjct: 693 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 752
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 753 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 812
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 813 MRRDLEE 819
Score = 55.6 bits (128), Expect = 6e-07
Identities = 102/517 (19%), Positives = 218/517 (42%), Gaps = 27/517 (5%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T +IED ++ + L K R + E +
Sbjct: 1040 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA--EWKQ 1097
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
K + + + E ++ T+ K+ + + +++ + L E+ D +L
Sbjct: 1098 KYEESQSELESSQKEARSLS-TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1156
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA-LEANESIRREYKIEL 281
S + I + + K L+ + + L E + LE +G A LE N+ K E+
Sbjct: 1157 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ-----IKAEI 1211
Query: 282 EALKTKLDEE-KQAIISKCKVDQENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLII 338
E + DEE +QA + +V ++L+T +A S + +K+K E L ++ QL
Sbjct: 1212 ERKLAEKDEEMEQAKRNHLRV-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS- 1269
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEER---SQSIQEHCSQQEKTIQYLEQEIKELKY 395
M A+ ++ +S LK +IQ ++ + ++E+ + E+ L+ E++EL+
Sbjct: 1270 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1329
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
++ T +QEL L ++ + I + K + +L + E +
Sbjct: 1330 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1389
Query: 456 AVE---KAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQM--LTSAKE 507
A E KAI + L +D H+ ++ + ++ +L+ D+ + L K+
Sbjct: 1390 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1449
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
L+ + N E E++ + KS+ + KE T E + + LQ++
Sbjct: 1450 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-KELTYQTEEDRKNLLRLQDLVD 1508
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ ++ K + E+ E + S+ + ++ E+++
Sbjct: 1509 KLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDE 1544
>Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 77.0 bits (181), Expect = 2e-13
Identities = 109/527 (20%), Positives = 230/527 (43%), Gaps = 58/527 (11%)
Query: 123 YNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF------------NEIDRKLSKLRIN 170
Y +Q+ED K ++ + + LA + + ++ D E+ R LSK
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 171 NTNCHTEH--NAVQGTDA-----EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
T++ +A+Q T+ +K++ + D + + KC +L+ + Q E+
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L + ++ L +K + + LAE +Q+ E + LE+++ R EL
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE----LESSQKEARSLSTELFK 1485
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK +E + + K + +NL+ + + E L + LE++ QL +++ E+
Sbjct: 1486 LKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGEG--GKNVHELEKVRKQLEVEKLEL 1542
Query: 344 KAKLEQIEESAS-EKLKICEIQFE------ERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
++ LE+ E S E+ KI Q E E + + E + E+ + ++ + L+ +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 397 LDL-TNNQNSDL---KQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTINYE-- 447
LD T ++N L K+ +L + +LS E ++K+L+ L + I +
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 448 ---NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
N+ K N+A+ + + N + L R +V + ++ EL + ++VQ+L S
Sbjct: 1663 VRANDDLKENIAIVE--RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHS 1720
Query: 505 A-------KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
K+ +E++LT ++ + V+EC +E + A + +E + + +
Sbjct: 1721 QNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA- 1779
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
L+ ++K + + +++ L E ++ K Q++ L V +
Sbjct: 1780 ---HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Score = 75.8 bits (178), Expect = 5e-13
Identities = 126/630 (20%), Positives = 268/630 (42%), Gaps = 48/630 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+Q ++ ++ + ++ + +Q++D + + Q +++ +L R+ ++ + S
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE----S 1067
Query: 166 KLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ + N E + D + ++ I D ++ ++L+KK + +N+ +++E
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLK--ENQARIEELE---- 1121
Query: 225 EEVITVRDSLCKDLQEKLTSN-ELTLAETQQRLEMVKGHHALALEANESIRREY-KIELE 282
EE+ R + K EKL S+ L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1122 EELEAERTARAK--VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179
Query: 283 ALKTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ L E A + K D + +++ +K ++ KEK E +L EQ
Sbjct: 1180 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 342 EMKAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LEQEIKELKYT 396
+KAK LE++ + ++ ++ EE +S+ + +Q+ K L ++++E +
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
Query: 397 LD-LTNN------QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
+ LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1359
Query: 450 KNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLTSA 505
+ L+ A + + + K+ET ++ T ++ L RL++++ +E + + L
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1420 KHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 566 EKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXXXX 619
+ EL +KN E +E +E K+E+ + +I L E++ +
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Query: 620 XXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVAKQ 678
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1536 EVEKLELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 679 SSIIDKLKKDLEQSQYTPKSPSVLRKSLKV 708
++D L+ L+ T VLR K+
Sbjct: 1593 QRVVDSLQTSLDAE--TRSRNEVLRVKKKM 1620
Score = 70.1 bits (164), Expect = 3e-11
Identities = 126/599 (21%), Positives = 260/599 (43%), Gaps = 68/599 (11%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNEL--- 247
I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE + ++L
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 248 -----TLAETQQRLEMVKGHHALALEANESIRREY-----KIELEALKTK-----LDEEK 292
+L++++ +LE +LE + +R + K+E + T+ L+ +K
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 293 QAIISKCK-----VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
+ K K ++Q+N K + ++ + LKE +E+L +L E+ +AK+
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEEEL-EAERTARAKV 1134
Query: 348 EQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYTLDLT---- 400
E++ S +L+ + EE + S+Q E ++E Q + ++++E + T
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 401 NNQNSD----LKQELNNLKNCKDELSTEKFNF---IEEIKTLKDELIEKTIN-------Y 446
+++D L ++++NL+ K +L EK F ++++ + +++I+ N
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE----DQVQML 502
E++ N+ + +E+A + N F T + + L +L E ++ + QL Q +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314
Query: 503 TSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNILKSKA----ALTKEHTRIMEHN 555
K LE E + L + +CD +E ++KA L+K ++ + +
Sbjct: 1315 EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1374
Query: 556 VTL-IESLQNVE--KEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLC 609
+++Q E +EA ++L + E VE + + +S K L+ E+E V
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E +LA+ ++E E + + +L +E+
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 670 ELTMTVAKQSSIIDKLKKDL-EQSQYTPKSPSVL---RKSLKVGKENMQTISPLRERNL 724
E T +++ + + DL EQ K+ L RK L+V K +Q+ E +L
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL 1553
Score = 67.3 bits (157), Expect = 2e-10
Identities = 91/498 (18%), Positives = 214/498 (42%), Gaps = 29/498 (5%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E K++ K E +++E L++ + + E++ K+ L + + A
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRK---------ELEEKMVSLLQEKNDLQLQVQAE 896
Query: 182 QGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q DAE+ + + I+LE K + ++ + D++ + L + C +L+
Sbjct: 897 QDNLNDAEE---RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ + ELTLA+ ++ + E + E +L K L E Q +
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-DEIIAKLTKEKKALQEAHQQALDDL 1012
Query: 300 KVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+V+++ + + + ++ L+ Q+ L+ E +++ L +++++ L+ +ES +
Sbjct: 1013 QVEEDKVNSLSKSKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD- 1070
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
L+ ++Q EE+ + + +QQ I+ + +L+ L + +L++EL +
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 418 KDELSTEKFNFIEEIKTLKDELIEK--TINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
+ ++ + + E++ + + L E + + E NK +A +K + + + +
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK----KREAEFQKMRRDLEEATLQ 1186
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
LR + +DS + +L +Q+ L K+ LE E + +K L++ ++ +A
Sbjct: 1187 HEATAAALRKKHADS-VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245
Query: 536 NILKSKAAL---TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
N+ K L E+ +E + + E G + +L E L+ + +
Sbjct: 1246 NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR 1305
Query: 593 SQIKFLREEVEKKRVLCE 610
++ + ++ + KR L E
Sbjct: 1306 GKLSYTQQMEDLKRQLEE 1323
Score = 66.9 bits (156), Expect = 2e-10
Identities = 95/451 (21%), Positives = 189/451 (41%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + + E K + + E +L
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ ++ ++KK E NE+ +++LS + K LQ L ++
Sbjct: 1603 LDAETRS-RNEVLRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ +QE ++T
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLAEQELIET 1711
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + +E +QL + +E + EE A + + + EE
Sbjct: 1712 SERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1771
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + + EL
Sbjct: 1772 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEA 1830
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E++K NL +D+V L
Sbjct: 1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR----------------LQDLVDKLQ 1874
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1905
Score = 63.7 bits (148), Expect = 2e-09
Identities = 102/489 (20%), Positives = 201/489 (41%), Gaps = 47/489 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AET++ + +K E E K ELE L +EK + + + +Q+NL
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
+E+C+ L + QL K +EM +LE EE +E
Sbjct: 901 NDA-------------EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE--------LT 939
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ +K I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 940 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L+ + K ++ + E SL + + L R
Sbjct: 1000 ALQEAHQQALDDLQVE----EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1055
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K LE +L + N N+ + + L LK A
Sbjct: 1056 KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQA 1115
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSR----LENENERYXXXXXX 653
+R ++E+ + E S L + +L R LE E +
Sbjct: 1176 MRRDLEEATLQHE---ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Query: 654 XXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENM 713
S + ++ + E+++ T+ Q+ ++ + LE++Q + + R L+ EN
Sbjct: 1233 VTSNMEQIIKAKANLEKVSRTLEDQA---NEYRVKLEEAQRSLNDFTTQRAKLQT--ENG 1287
Query: 714 QTISPLRER 722
+ L E+
Sbjct: 1288 ELARQLEEK 1296
Score = 53.2 bits (122), Expect = 3e-06
Identities = 66/325 (20%), Positives = 149/325 (45%), Gaps = 32/325 (9%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
D ++ ++ E +K+ ++L + + D Q++L ++ + D L +++
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL---DDAVRANDDLKENIAIVERR 1679
Query: 245 NELTLAETQQ-RLEMVKGHHALALEANESIRREYKIEL-EALKTKLDEEKQAIISKCKVD 302
N L AE ++ R + + + L E I +++L + T L +K+ K + D
Sbjct: 1680 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK----KMESD 1735
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQ-LHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+++ +++ +N K K + + ++ + KEQ+ A LE+++++ + +K
Sbjct: 1736 LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1795
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQELNNLKNC 417
+ + +E Q + +Q +Q LE ++EL+ L+ +N++ +++ +K
Sbjct: 1796 QHRLDEAEQIALKGGKKQ---LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL 1852
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
+ +K N + ++ L D+L K Y+ + E+A ++ N T+LS R +
Sbjct: 1853 TYQTEEDKKNLL-RLQDLVDKLQLKVKAYKRQ-------AEEAEEQAN---TNLSKFRKV 1901
Query: 478 VHVLTLRLRESDSELEQLEDQVQML 502
H L E++ + E QV L
Sbjct: 1902 QH----ELDEAEERADIAESQVNKL 1922
>X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin heavy
chain protein.
Length = 881
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 83 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 142
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 143 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 201
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 202 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 257
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 258 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 311
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 312 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 371
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 372 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 427
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 428 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 487
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 488 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 533
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 534 DLKDLELQADSAIKGREEAIKQLRKL 559
Score = 73.3 bits (172), Expect = 3e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 318 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 376
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 377 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 436
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 437 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 496
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 497 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 551
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 552 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 609
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 610 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 662
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 663 AMSDRVRKATQQAEQLSNELATERSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKFK 722
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 723 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 778
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 779 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 818
Score = 68.1 bits (159), Expect = 1e-10
Identities = 110/519 (21%), Positives = 221/519 (42%), Gaps = 43/519 (8%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY 277
Q L+ L++ I +++ K ++E E +++ Q+ L+ + A E +R+
Sbjct: 2 QAALARLDDEIAQKNNALKKIREL----EGHISDLQEDLDSERA----ARNKAEKQKRDL 53
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
ELEALKT+L++ + + Q+ L+ K + LK + L E+ + E
Sbjct: 54 GEELEALKTELEDTLDSTAT-----QQELRAKREQEVTVLK-KALDEETRSHE------- 100
Query: 338 IKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTL 397
+ QEM+ K Q E +E+L+ QF+ ++ ++ EK L E++ L
Sbjct: 101 AQVQEMRQKHAQAVEELTEQLE----QFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 156
Query: 398 DLTNNQNSDLKQELNNLKN-CKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLN 454
++ L+ ++ L++ C D E + + N +++ L++E+ T + E E +
Sbjct: 157 QEVEHKKKKLEAQVQELQSKCSDGERARAELN--DKVHKLQNEVESVTGMLNEAEGKAIK 214
Query: 455 LAVEKAIKEKNKFETS---LSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
LA + A +T TR ++V T +LR+ + E L+DQ+ AK+ LE
Sbjct: 215 LAKDVASLSSQLQDTQELLQEETRQKLNVST-KLRQLEEERNSLQDQLDEEMEAKQNLER 273
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE---HTRIMEHNVTLIESLQNVEKE 568
++T L+++ ++ ++ + + + K KE T+ E + L+ +
Sbjct: 274 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 333
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX--XXXXXXXXXXXXXS 626
+EL + +L +L+ Q KF + E+K + +
Sbjct: 334 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 393
Query: 627 RVLLAQAAADLSRLENENER-YXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKL 685
+ LA+A + + E ER LV + + EL + + ++++
Sbjct: 394 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 453
Query: 686 KKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
K LE+ + ++ + L+V NMQ + ER+L
Sbjct: 454 KTQLEELEDELQATEDAKLRLEV---NMQALKGQFERDL 489
Score = 60.5 bits (140), Expect = 2e-08
Identities = 113/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 217 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 274
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 275 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 331
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 332 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 391
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 392 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 447
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 448 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 504
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 505 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 563
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 564 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 623
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 624 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 683
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +S+ + R+ E + L EM +AQ + +
Sbjct: 684 TERSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 743
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 744 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 803
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 804 RINANRRKLQ 813
>BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6,
cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
protein.
Length = 1939
Score = 77.0 bits (181), Expect = 2e-13
Identities = 109/527 (20%), Positives = 230/527 (43%), Gaps = 58/527 (11%)
Query: 123 YNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF------------NEIDRKLSKLRIN 170
Y +Q+ED K ++ + + LA + + ++ D E+ R LSK
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 171 NTNCHTEH--NAVQGTDA-----EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
T++ +A+Q T+ +K++ + D + + KC +L+ + Q E+
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L + ++ L +K + + LAE +Q+ E + LE+++ R EL
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE----LESSQKEARSLSTELFK 1485
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK +E + + K + +NL+ + + E L + LE++ QL +++ E+
Sbjct: 1486 LKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGEG--GKNVHELEKVRKQLEVEKLEL 1542
Query: 344 KAKLEQIEESAS-EKLKICEIQFE------ERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
++ LE+ E S E+ KI Q E E + + E + E+ + ++ + L+ +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 397 LDL-TNNQNSDL---KQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTINYE-- 447
LD T ++N L K+ +L + +LS E ++K+L+ L + I +
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 448 ---NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
N+ K N+A+ + + N + L R +V + ++ EL + ++VQ+L S
Sbjct: 1663 VRANDDLKENIAIVE--RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHS 1720
Query: 505 A-------KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
K+ +E++LT ++ + V+EC +E + A + +E + + +
Sbjct: 1721 QNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA- 1779
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
L+ ++K + + +++ L E ++ K Q++ L V +
Sbjct: 1780 ---HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Score = 74.5 bits (175), Expect = 1e-12
Identities = 126/630 (20%), Positives = 267/630 (42%), Gaps = 48/630 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+Q ++ ++ + ++ + +Q++D + + Q +++ +L R+ ++ + S
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE----S 1067
Query: 166 KLRINNTNCHTEHNAVQGT-DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ + N E + D + ++ I D + ++L+KK + +N+ +++E
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK--ENQARIEELE---- 1121
Query: 225 EEVITVRDSLCKDLQEKLTSN-ELTLAETQQRLEMVKGHHALALEANESIRREY-KIELE 282
EE+ R + K EKL S+ L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 1122 EELEAERTARAK--VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179
Query: 283 ALKTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ L E A + K D + +++ +K ++ KEK E +L EQ
Sbjct: 1180 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 342 EMKAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LEQEIKELKYT 396
+KAK LE++ + ++ ++ EE +S+ + +Q+ K L ++++E +
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
Query: 397 LD-LTNN------QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
+ LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1359
Query: 450 KNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLTSA 505
+ L+ A + + + K+ET ++ T ++ L RL++++ +E + + L
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 1420 KHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 566 EKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXXXX 619
+ EL +KN E +E +E K+E+ + +I L E++ +
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Query: 620 XXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVAKQ 678
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 1536 EVEKLELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 679 SSIIDKLKKDLEQSQYTPKSPSVLRKSLKV 708
++D L+ L+ T VLR K+
Sbjct: 1593 QRVVDSLQTSLDAE--TRSRNEVLRVKKKM 1620
Score = 68.9 bits (161), Expect = 6e-11
Identities = 126/599 (21%), Positives = 259/599 (43%), Gaps = 68/599 (11%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLTSNEL--- 247
I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE + ++L
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 248 -----TLAETQQRLEMVKGHHALALEANESIRREY-----KIELEALKTK-----LDEEK 292
+L++++ +LE +LE + +R + K+E + T+ L+ +K
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 293 QAIISKCK-----VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
+ K K ++Q+N K + + + LKE +E+L +L E+ +AK+
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL-EAERTARAKV 1134
Query: 348 EQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYTLDLT---- 400
E++ S +L+ + EE + S+Q E ++E Q + ++++E + T
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 401 NNQNSD----LKQELNNLKNCKDELSTEKFNF---IEEIKTLKDELIEKTIN-------Y 446
+++D L ++++NL+ K +L EK F ++++ + +++I+ N
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE----DQVQML 502
E++ N+ + +E+A + N F T + + L +L E ++ + QL Q +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314
Query: 503 TSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNILKSKA----ALTKEHTRIMEHN 555
K LE E + L + +CD +E ++KA L+K ++ + +
Sbjct: 1315 EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1374
Query: 556 VTL-IESLQNVE--KEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLC 609
+++Q E +EA ++L + E VE + + +S K L+ E+E V
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E +LA+ ++E E + + +L +E+
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 670 ELTMTVAKQSSIIDKLKKDL-EQSQYTPKSPSVL---RKSLKVGKENMQTISPLRERNL 724
E T +++ + + DL EQ K+ L RK L+V K +Q+ E +L
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL 1553
Score = 68.5 bits (160), Expect = 8e-11
Identities = 93/500 (18%), Positives = 217/500 (43%), Gaps = 33/500 (6%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E K++ K E +++E L++ + + E++ K+ L + + A
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRK---------ELEEKMVSLLQEKNDLQLQVQAE 896
Query: 182 QGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q DAE+ + + I+LE K + ++ + D++ + L + C +L+
Sbjct: 897 QDNLNDAEE---RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
+ + ELTLA+ ++ + E + E +L K L E Q +
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-DEIIAKLTKEKKALQEAHQQALDDL 1012
Query: 300 KVDQENLKTKHNASIESLKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+V+++ + + + ++ L+ Q+ L+ E +++ L +++++ L+ +ES +
Sbjct: 1013 QVEEDKVNSLSKSKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD- 1070
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN--SDLKQELNNLK 415
L+ ++Q EE+ + + +QQ I+ ++++ L+ L NQ +L++EL +
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIE--DEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIEK--TINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
+ ++ + + E++ + + L E + + E NK +A +K + + +
Sbjct: 1129 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK----KREAEFQKMRRDLEEAT 1184
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ LR + +DS + +L +Q+ L K+ LE E + +K L++ ++ +A
Sbjct: 1185 LQHEATAAALRKKHADS-VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 534 LVNILKSKAAL---TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
N+ K L E+ +E + + E G + +L E L+ +
Sbjct: 1244 KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL 1303
Query: 591 SNSQIKFLREEVEKKRVLCE 610
+ ++ + ++ + KR L E
Sbjct: 1304 TRGKLSYTQQMEDLKRQLEE 1323
Score = 66.9 bits (156), Expect = 2e-10
Identities = 95/451 (21%), Positives = 189/451 (41%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + + E K + + E +L
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ ++ ++KK E NE+ +++LS + K LQ L ++
Sbjct: 1603 LDAETRS-RNEVLRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ +QE ++T
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLAEQELIET 1711
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + +E +QL + +E + EE A + + + EE
Sbjct: 1712 SERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1771
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + + EL
Sbjct: 1772 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEA 1830
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E++K NL +D+V L
Sbjct: 1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR----------------LQDLVDKLQ 1874
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1905
Score = 63.3 bits (147), Expect = 3e-09
Identities = 102/489 (20%), Positives = 201/489 (41%), Gaps = 47/489 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AET++ + +K E E K ELE L +EK + + + +Q+NL
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
+E+C+ L + QL K +EM +LE EE +E
Sbjct: 901 NDA-------------EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE--------LT 939
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ +K I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 940 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L+ + K ++ + E SL + + L R
Sbjct: 1000 ALQEAHQQALDDLQVE----EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1055
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K LE +L + N N+ + + L LK A
Sbjct: 1056 KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQA 1115
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSR----LENENERYXXXXXX 653
+R ++E+ + E S L + +L R LE E +
Sbjct: 1176 MRRDLEEATLQHE---ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Query: 654 XXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENM 713
S + ++ + E+++ T+ Q+ ++ + LE++Q + + R L+ EN
Sbjct: 1233 VTSNMEQIIKAKANLEKVSRTLEDQA---NEYRVKLEEAQRSLNDFTTQRAKLQT--ENG 1287
Query: 714 QTISPLRER 722
+ L E+
Sbjct: 1288 ELARQLEEK 1296
Score = 53.2 bits (122), Expect = 3e-06
Identities = 66/325 (20%), Positives = 149/325 (45%), Gaps = 32/325 (9%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
D ++ ++ E +K+ ++L + + D Q++L ++ + D L +++
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL---DDAVRANDDLKENIAIVERR 1679
Query: 245 NELTLAETQQ-RLEMVKGHHALALEANESIRREYKIEL-EALKTKLDEEKQAIISKCKVD 302
N L AE ++ R + + + L E I +++L + T L +K+ K + D
Sbjct: 1680 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK----KMESD 1735
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQ-LHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+++ +++ +N K K + + ++ + KEQ+ A LE+++++ + +K
Sbjct: 1736 LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1795
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQELNNLKNC 417
+ + +E Q + +Q +Q LE ++EL+ L+ +N++ +++ +K
Sbjct: 1796 QHRLDEAEQIALKGGKKQ---LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL 1852
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
+ +K N + ++ L D+L K Y+ + E+A ++ N T+LS R +
Sbjct: 1853 TYQTEEDKKNLL-RLQDLVDKLQLKVKAYKRQ-------AEEAEEQAN---TNLSKFRKV 1901
Query: 478 VHVLTLRLRESDSELEQLEDQVQML 502
H L E++ + E QV L
Sbjct: 1902 QH----ELDEAEERADIAESQVNKL 1922
>BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 1348
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 1349 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 1402
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 1579 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKL 1650
Score = 73.7 bits (173), Expect = 2e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 1642
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 1643 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 1701 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1813
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 1814 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 1870 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1909
Score = 64.5 bits (150), Expect = 1e-09
Identities = 134/632 (21%), Positives = 264/632 (41%), Gaps = 65/632 (10%)
Query: 95 PKNKILPQDELVQAQDVEI---RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
P ++ Q+E +QA++ E+ + + Q K++E +++ + + +L+E +
Sbjct: 843 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 152 HNNIDFNEIDRKLSKLRINN------TNCHTEHNAVQGTDAE--KVSAMINDMRSRIIEL 203
+ + + K + E + Q AE K++ + D+ ++ E
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDS----LCKD---LQEKLTSNELTLAETQQR- 255
E + L E + ++ LE+ I V D L K+ L+E+++ LAE +++
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 256 --LEMVKG-HHALALEANESIRREYKI--ELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
L +K H ++ E +++E K ELE LK KL+ + D
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS--------DFHEQIADL 1074
Query: 311 NASIESLKNQMLKEKCE---ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
A I LK Q+ K++ E AL +L ++ K +K K+ ++E S+ + ++ E
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQE--DLDSER 1131
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN---SDLKQELNNLKNCKDELSTE 424
+++ E Q+ + LE EL+ TLD T Q + +QE+ LK DE +
Sbjct: 1132 AARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 425 KFNFIEEIKTLKDELIEK-TINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
++E++ + +E+ T E K K NL K EK + + + VL
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-----RVLG 1244
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
+E + + ++LE QVQ L S + + E + LN+ V + E++ +L
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQS--KCSDGERA--RAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+ + + + ++ Q + +E R+ + +L + L++E NS L EE+
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEM 1356
Query: 603 EKKRVL------CEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXXX 655
E K+ L + + L + + +EN ++Y
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 656 SLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L + L+QE ++L + + Q ++ L+K
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Score = 59.3 bits (137), Expect = 5e-08
Identities = 112/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 1365
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 1366 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 1483 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 1538
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 1595
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1895 RINANRRKLQ 1904
>BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 1348
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 1349 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 1402
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 1579 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKL 1650
Score = 73.7 bits (173), Expect = 2e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 1642
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 1643 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 1701 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1813
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 1814 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 1870 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1909
Score = 64.5 bits (150), Expect = 1e-09
Identities = 134/632 (21%), Positives = 264/632 (41%), Gaps = 65/632 (10%)
Query: 95 PKNKILPQDELVQAQDVEI---RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
P ++ Q+E +QA++ E+ + + Q K++E +++ + + +L+E +
Sbjct: 843 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 152 HNNIDFNEIDRKLSKLRINN------TNCHTEHNAVQGTDAE--KVSAMINDMRSRIIEL 203
+ + + K + E + Q AE K++ + D+ ++ E
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDS----LCKD---LQEKLTSNELTLAETQQR- 255
E + L E + ++ LE+ I V D L K+ L+E+++ LAE +++
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 256 --LEMVKG-HHALALEANESIRREYKI--ELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
L +K H ++ E +++E K ELE LK KL+ + D
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS--------DFHEQIADL 1074
Query: 311 NASIESLKNQMLKEKCE---ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
A I LK Q+ K++ E AL +L ++ K +K K+ ++E S+ + ++ E
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQE--DLDSER 1131
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN---SDLKQELNNLKNCKDELSTE 424
+++ E Q+ + LE EL+ TLD T Q + +QE+ LK DE +
Sbjct: 1132 AARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 425 KFNFIEEIKTLKDELIEK-TINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
++E++ + +E+ T E K K NL K EK + + + VL
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-----RVLG 1244
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
+E + + ++LE QVQ L S + + E + LN+ V + E++ +L
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQS--KCSDGERA--RAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+ + + + ++ Q + +E R+ + +L + L++E NS L EE+
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEM 1356
Query: 603 EKKRVL------CEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXXX 655
E K+ L + + L + + +EN ++Y
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 656 SLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L + L+QE ++L + + Q ++ L+K
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Score = 59.3 bits (137), Expect = 5e-08
Identities = 112/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 1365
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 1366 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 1483 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 1538
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 1595
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1895 RINANRRKLQ 1904
>AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin heavy
chain isoform SM2 protein.
Length = 1945
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 1355
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 1356 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 1409
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 1586 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKL 1657
Score = 73.7 bits (173), Expect = 2e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 1649
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 1650 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 1708 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1820
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 1821 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 1877 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1916
Score = 64.5 bits (150), Expect = 1e-09
Identities = 134/632 (21%), Positives = 264/632 (41%), Gaps = 65/632 (10%)
Query: 95 PKNKILPQDELVQAQDVEI---RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
P ++ Q+E +QA++ E+ + + Q K++E +++ + + +L+E +
Sbjct: 850 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 152 HNNIDFNEIDRKLSKLRINN------TNCHTEHNAVQGTDAE--KVSAMINDMRSRIIEL 203
+ + + K + E + Q AE K++ + D+ ++ E
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDS----LCKD---LQEKLTSNELTLAETQQR- 255
E + L E + ++ LE+ I V D L K+ L+E+++ LAE +++
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 256 --LEMVKG-HHALALEANESIRREYKI--ELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
L +K H ++ E +++E K ELE LK KL+ + D
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS--------DFHEQIADL 1081
Query: 311 NASIESLKNQMLKEKCE---ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
A I LK Q+ K++ E AL +L ++ K +K K+ ++E S+ + ++ E
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQE--DLDSER 1138
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN---SDLKQELNNLKNCKDELSTE 424
+++ E Q+ + LE EL+ TLD T Q + +QE+ LK DE +
Sbjct: 1139 AARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 425 KFNFIEEIKTLKDELIEK-TINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
++E++ + +E+ T E K K NL K EK + + + VL
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-----RVLG 1251
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
+E + + ++LE QVQ L S + + E + LN+ V + E++ +L
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQS--KCSDGERA--RAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+ + + + ++ Q + +E R+ + +L + L++E NS L EE+
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEM 1363
Query: 603 EKKRVL------CEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXXX 655
E K+ L + + L + + +EN ++Y
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 656 SLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L + L+QE ++L + + Q ++ L+K
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Score = 59.3 bits (137), Expect = 5e-08
Identities = 112/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 1372
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 1373 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 1490 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 1545
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 1602
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1902 RINANRRKLQ 1911
>AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin heavy
chain isoform SM1 protein.
Length = 1979
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 1355
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 1356 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 1409
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 1586 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKL 1657
Score = 73.7 bits (173), Expect = 2e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 1649
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 1650 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 1708 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1820
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 1821 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 1877 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1916
Score = 64.5 bits (150), Expect = 1e-09
Identities = 134/632 (21%), Positives = 264/632 (41%), Gaps = 65/632 (10%)
Query: 95 PKNKILPQDELVQAQDVEI---RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
P ++ Q+E +QA++ E+ + + Q K++E +++ + + +L+E +
Sbjct: 850 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 152 HNNIDFNEIDRKLSKLRINN------TNCHTEHNAVQGTDAE--KVSAMINDMRSRIIEL 203
+ + + K + E + Q AE K++ + D+ ++ E
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDS----LCKD---LQEKLTSNELTLAETQQR- 255
E + L E + ++ LE+ I V D L K+ L+E+++ LAE +++
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 256 --LEMVKG-HHALALEANESIRREYKI--ELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
L +K H ++ E +++E K ELE LK KL+ + D
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS--------DFHEQIADL 1081
Query: 311 NASIESLKNQMLKEKCE---ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
A I LK Q+ K++ E AL +L ++ K +K K+ ++E S+ + ++ E
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQE--DLDSER 1138
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN---SDLKQELNNLKNCKDELSTE 424
+++ E Q+ + LE EL+ TLD T Q + +QE+ LK DE +
Sbjct: 1139 AARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 425 KFNFIEEIKTLKDELIEK-TINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
++E++ + +E+ T E K K NL K EK + + + VL
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-----RVLG 1251
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
+E + + ++LE QVQ L S + + E + LN+ V + E++ +L
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQS--KCSDGERA--RAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+ + + + ++ Q + +E R+ + +L + L++E NS L EE+
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEM 1363
Query: 603 EKKRVL------CEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXXX 655
E K+ L + + L + + +EN ++Y
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 656 SLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L + L+QE ++L + + Q ++ L+K
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Score = 59.3 bits (137), Expect = 5e-08
Identities = 112/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 1372
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 1373 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 1490 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 1545
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 1602
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1902 RINANRRKLQ 1911
>AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY11)
(5'partial) protein.
Length = 1857
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 1059 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1118
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 1119 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1177
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 1178 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 1233
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 1234 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 1287
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 1288 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1347
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 1348 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 1403
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 1404 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1463
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 1464 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1509
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 1510 DLKDLELQADSAIKGREEAIKQLRKL 1535
Score = 73.7 bits (173), Expect = 2e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 1294 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 1352
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 1353 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1412
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 1413 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1472
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 1473 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 1527
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 1528 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 1585
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 1586 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1638
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 1639 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1698
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 1699 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1754
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 1755 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1794
Score = 64.5 bits (150), Expect = 1e-09
Identities = 134/632 (21%), Positives = 264/632 (41%), Gaps = 65/632 (10%)
Query: 95 PKNKILPQDELVQAQDVEI---RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
P ++ Q+E +QA++ E+ + + Q K++E +++ + + +L+E +
Sbjct: 728 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 787
Query: 152 HNNIDFNEIDRKLSKLRINN------TNCHTEHNAVQGTDAE--KVSAMINDMRSRIIEL 203
+ + + K + E + Q AE K++ + D+ ++ E
Sbjct: 788 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 847
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDS----LCKD---LQEKLTSNELTLAETQQR- 255
E + L E + ++ LE+ I V D L K+ L+E+++ LAE +++
Sbjct: 848 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 907
Query: 256 --LEMVKG-HHALALEANESIRREYKI--ELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
L +K H ++ E +++E K ELE LK KL+ + D
Sbjct: 908 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS--------DFHEQIADL 959
Query: 311 NASIESLKNQMLKEKCE---ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
A I LK Q+ K++ E AL +L ++ K +K K+ ++E S+ + ++ E
Sbjct: 960 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQE--DLDSER 1016
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN---SDLKQELNNLKNCKDELSTE 424
+++ E Q+ + LE EL+ TLD T Q + +QE+ LK DE +
Sbjct: 1017 AARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1074
Query: 425 KFNFIEEIKTLKDELIEK-TINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
++E++ + +E+ T E K K NL K EK + + + VL
Sbjct: 1075 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-----RVLG 1129
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
+E + + ++LE QVQ L S + + E + LN+ V + E++ +L
Sbjct: 1130 QAKQEVEHKKKKLEAQVQELQS--KCSDGERA--RAELNDKVHKLQNEVESVTGMLNEAE 1185
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+ + + + ++ Q + +E R+ + +L + L++E NS L EE+
Sbjct: 1186 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEM 1241
Query: 603 EKKRVL------CEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXXX 655
E K+ L + + L + + +EN ++Y
Sbjct: 1242 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1301
Query: 656 SLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L + L+QE ++L + + Q ++ L+K
Sbjct: 1302 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1333
Score = 59.3 bits (137), Expect = 5e-08
Identities = 112/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 1193 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 1250
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 1251 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1307
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 1308 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1367
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 1368 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 1423
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 1424 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 1480
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 1481 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1539
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 1540 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1599
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 1600 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1659
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 1660 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1719
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 1720 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1779
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1780 RINANRRKLQ 1789
>AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein.
Length = 1984
Score = 77.0 bits (181), Expect = 2e-13
Identities = 100/506 (19%), Positives = 216/506 (42%), Gaps = 35/506 (6%)
Query: 109 QDVEIRNK--DQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE--IDRKL 164
Q+V + K D+ + Q+++ + + AQ E L E +F+++ N+D N+ ++++
Sbjct: 1186 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1245
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
+ L V+ +K+ A + +++S+ + E+ L+++V+ Q E+ S+
Sbjct: 1246 ADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1304
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEAL 284
++ + L + + S L +TQ E+++ L + +R + + E +L
Sbjct: 1305 TGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVSTKLR-QLEEERNSL 1360
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
+ +LDEE +A K +++ S K Q EALE+ + ++E++
Sbjct: 1361 QDQLDEEMEA---KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF---QKEIE 1414
Query: 345 AKLEQIEESAS--EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+Q EE A+ +KL+ + + ++ + Q + + LE++ ++ L N
Sbjct: 1415 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1474
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+S E + + E T+ + + +E +E E L +E +
Sbjct: 1475 ISSKYADERDRAEAEAREKETKALSLARAL----EEALEAKEELERTNKMLKAEMEDLVS 1530
Query: 463 EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN 522
K+ ++ L ++ E ++LE+LED++Q AK LE + K
Sbjct: 1531 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1590
Query: 523 TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE 582
++ DE E E R ++ + E+ E++ K +L
Sbjct: 1591 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1636
Query: 583 DVELLKKESNSQIKFLREEVEKKRVL 608
D++ L+ +++S IK E +++ R L
Sbjct: 1637 DLKDLELQADSAIKGREEAIKQLRKL 1662
Score = 73.7 bits (173), Expect = 2e-12
Identities = 111/521 (21%), Positives = 234/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 1421 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 1479
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 1480 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1539
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 1540 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1599
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 1600 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 1654
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++QL +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 1655 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 1712
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 1713 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1765
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 1766 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 1825
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 1826 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1881
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 1882 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 1921
Score = 64.5 bits (150), Expect = 1e-09
Identities = 134/632 (21%), Positives = 264/632 (41%), Gaps = 65/632 (10%)
Query: 95 PKNKILPQDELVQAQDVEI---RNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
P ++ Q+E +QA++ E+ + + Q K++E +++ + + +L+E +
Sbjct: 855 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 914
Query: 152 HNNIDFNEIDRKLSKLRINN------TNCHTEHNAVQGTDAE--KVSAMINDMRSRIIEL 203
+ + + K + E + Q AE K++ + D+ ++ E
Sbjct: 915 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 974
Query: 204 EKKCEALDNEVYDKQMELSSLEEVITVRDS----LCKD---LQEKLTSNELTLAETQQR- 255
E + L E + ++ LE+ I V D L K+ L+E+++ LAE +++
Sbjct: 975 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1034
Query: 256 --LEMVKG-HHALALEANESIRREYKI--ELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
L +K H ++ E +++E K ELE LK KL+ + D
Sbjct: 1035 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS--------DFHEQIADL 1086
Query: 311 NASIESLKNQMLKEKCE---ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
A I LK Q+ K++ E AL +L ++ K +K K+ ++E S+ + ++ E
Sbjct: 1087 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQE--DLDSER 1143
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN---SDLKQELNNLKNCKDELSTE 424
+++ E Q+ + LE EL+ TLD T Q + +QE+ LK DE +
Sbjct: 1144 AARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1201
Query: 425 KFNFIEEIKTLKDELIEK-TINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
++E++ + +E+ T E K K NL K EK + + + VL
Sbjct: 1202 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-----RVLG 1256
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
+E + + ++LE QVQ L S + + E + LN+ V + E++ +L
Sbjct: 1257 QAKQEVEHKKKKLEAQVQELQS--KCSDGERA--RAELNDKVHKLQNEVESVTGMLNEAE 1312
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+ + + + ++ Q + +E R+ + +L + L++E NS L EE+
Sbjct: 1313 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEM 1368
Query: 603 EKKRVL------CEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXXX 655
E K+ L + + L + + +EN ++Y
Sbjct: 1369 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1428
Query: 656 SLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L + L+QE ++L + + Q ++ L+K
Sbjct: 1429 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1460
Score = 59.3 bits (137), Expect = 5e-08
Identities = 112/610 (18%), Positives = 240/610 (39%), Gaps = 40/610 (6%)
Query: 125 KQIEDYKNEIAQLQEILKE-------LATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCH 175
K + +++ QE+L+E ++TK RQ N +++D ++ + N H
Sbjct: 1320 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERH 1377
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLC 235
+Q +D++K + D S + LE+ + E+ + + +
Sbjct: 1378 ISTLNIQLSDSKK---KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1434
Query: 236 KDLQEKLTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK 292
LQ++L + L +Q LE + L ++I +Y E + + + E++
Sbjct: 1435 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1494
Query: 293 QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE 352
+S + +E L+ K N+MLK + E L + E++ K ++ E
Sbjct: 1495 TKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALE 1550
Query: 353 SASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L
Sbjct: 1551 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQ 1607
Query: 413 N-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
L + EL E+ K +L + E + + E+AIK+ K + +
Sbjct: 1608 RQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1666
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+ + E + ++ E + + L + L+ +L + E +E
Sbjct: 1667 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1726
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELI 581
E L + L + AL E R+ L E L+ N+E ++A ++ + NEL
Sbjct: 1727 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1786
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K +++ + R+ E + L EM +AQ + +
Sbjct: 1787 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1846
Query: 642 NENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPK 697
E + + E+ L R+ E+ K ++ + +LK+ LE+++ +
Sbjct: 1847 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1906
Query: 698 SPSVLRKSLK 707
+ R+ L+
Sbjct: 1907 RINANRRKLQ 1916
>BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1,
skeletal muscle, adult protein.
Length = 1939
Score = 76.6 bits (180), Expect = 3e-13
Identities = 124/622 (19%), Positives = 257/622 (41%), Gaps = 53/622 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S +KK + + + ++ A + +++N + + ++ I E LQE ++
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 146 TKFRQSHNNIDFNEIDRKLSKL--RINNTNCHTEHNAVQGTDAEKVSAMIN-DMR---SR 199
+ + + N + + KL ++++ E D E+ + D++
Sbjct: 1012 DDLQAEEDKV--NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 200 IIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMV 259
+++E + LD ++ K+ E+S L+ I +L LQ+K+ + + E ++ +E
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE 1129
Query: 260 KGHHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKH 310
+ A A + + RE + E L + +++++++A K + D E +H
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
A+ +L+ K+ +++ +L Q I Q +K KLE +E + K++I ++ +
Sbjct: 1190 EATAATLR----KKHADSVAELGEQ-IDNLQRVKQKLE--KEKSEMKMEIDDL--ASNME 1240
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
++ + EK + LE ++ E+K + +DL + L+ E S + ++
Sbjct: 1241 TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ----LD 1296
Query: 431 EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
E TL +L + + +L +E+ IK K+ +L +R H L + +
Sbjct: 1297 EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSR---HDCDLLREQYEE 1353
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E + + ++ A + T Y+ E +E K+ L L+ +EH
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD----AEEHVE 1409
Query: 551 IMEHNVTLIE-SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+ +E + Q ++ E + ++ L KK+ N K L E +K C
Sbjct: 1410 AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD-KILAEWKQK----C 1464
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
E SR L + +L +++N Y +L E L+QE
Sbjct: 1465 E---ETHAELEASQKESRSL----STELFKIKN---AYEESLDQLETLKRENKNLQQEIS 1514
Query: 670 ELTMTVAKQSSIIDKLKKDLEQ 691
+LT +A+ I +LKK +Q
Sbjct: 1515 DLTEQIAEGGKRIHELKKIKKQ 1536
Score = 61.7 bits (143), Expect = 9e-09
Identities = 110/522 (21%), Positives = 218/522 (41%), Gaps = 37/522 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T ++ED ++ + L K R D+
Sbjct: 1405 EEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRN---------FDK 1455
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
L++ + H E A Q ++ +S + +++ E + E L E + Q E+S
Sbjct: 1456 ILAEWKQKCEETHAELEASQ-KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E I +L++ E +E Q LE + +LE E ++EL
Sbjct: 1515 DLTEQIAEGGKRIHELKKIKKQVEQEKSELQAALEEAEA----SLEHEEGKILRIQLELN 1570
Query: 283 ALKTKLDE---EKQAIISKCKVDQ----ENLKTKHNASIESLKNQM-LKEKCEA-LEQLH 333
+K+++D EK I + K + E++++ +A I S + + LK+K E L ++
Sbjct: 1571 QVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1630
Query: 334 SQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE--RSQS-IQEHCSQQEKTIQYLEQEI 390
QL M A+ + + LK ++ ++ RSQ ++E + E+ L+ EI
Sbjct: 1631 IQLN-HANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEI 1689
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN-- 448
+EL+ TL+ T +QEL + L T+ + I K L+ ++ + E+
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 449 -EKNKLNLAVEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQMLT- 503
E +KAI + L +D H+ ++ L ++ +L+ D+ + L
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Query: 504 -SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
K+ ++ +L L V + V L+ KE T E + I L
Sbjct: 1810 KGGKKQIQ-KLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL 1868
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
Q++ + ++ + K + E+ E + S+ + ++ E+E+
Sbjct: 1869 QDLVDKLQAKVKSYKRQ-AEEAEEQSNVNLSKFRRIQHELEE 1909
Score = 61.3 bits (142), Expect = 1e-08
Identities = 82/423 (19%), Positives = 188/423 (44%), Gaps = 21/423 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + ++ K+ + +K + ++ L+ K ++ + L+ + EA E
Sbjct: 848 ETEKEMANMKEEFEKTKEEL-AKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A ++ +I + + + +++ CS+ +K I LE +
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +E+ L +L+ EK E + D+L + E++
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE----EDKV 1021
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N L A K ++ + E SL + I L R+ + +L+ ++ + + K+ L+
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+L + ++ + ++ ++AL L+ K KE +E IE+ + +A
Sbjct: 1082 EKLKKKEFEMSGLQSKIED-EQALGMQLQKK---IKELQARIEELEEEIEAERASRAKAE 1137
Query: 571 RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
++ + EL E E L++ + + +++ +M + L
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 631 AQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM---TVAKQSSIIDKLKK 687
+ A ++ L E+ L E S ++ E ++L TV+K ++K+ +
Sbjct: 1198 KKHADSVAEL---GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254
Query: 688 DLE 690
LE
Sbjct: 1255 ALE 1257
>AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting citron
kinase protein.
Length = 2027
Score = 76.2 bits (179), Expect = 4e-13
Identities = 97/476 (20%), Positives = 211/476 (44%), Gaps = 36/476 (7%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
SS+K++L + ++ +D+ +IR + + + E +Q +Y+ ++ +++ ++ +L
Sbjct: 515 SSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLE 572
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ D E + + S+L T C +H ++ D K
Sbjct: 573 EDLVSARRRSDLYESELRESRLAAEEFKRKATEC--QHKLLKAKDQGKPEV------GEY 624
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LEK ++ + Q +L + T L +++++ E L + Q R + +
Sbjct: 625 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSE 684
Query: 261 GHHALALEANE--SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
G +EA E RE ++ + L+ L +++Q K KV +K K A E+L+
Sbjct: 685 GIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK-KDLADKETLE 743
Query: 319 NQMLKEKCEALEQ--LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
N M + + EA E+ + S+ M +K+ +E+ E + ++ S Q +
Sbjct: 744 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS-SLFTQRNM 802
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
QE+ I L Q+ L+ QN L+++L + + +D ++K +E L+
Sbjct: 803 KAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH-QDH--SDKNRLLE----LE 855
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE--- 493
L E ++ +E +K +L + + + E+ L+ + L +LR++ +ELE
Sbjct: 856 TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 915
Query: 494 -QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEH 548
+ E+++Q LT+ ++ ++ + + L N+ + +E L + + A L ++
Sbjct: 916 AEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQN 967
Score = 64.5 bits (150), Expect = 1e-09
Identities = 112/564 (19%), Positives = 233/564 (41%), Gaps = 48/564 (8%)
Query: 155 IDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE---LEKKCEALD 211
++ E++ K + +++ + + EK+ + N ++ + + LE + +
Sbjct: 691 VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE 750
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E ++K LS + +I DS + L++++ L+E + + + +L + N
Sbjct: 751 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVE----LSEANK----LAANSSLFTQRNM 802
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
+ E EL K L E QA K++ +N K + +E + +Q +K LE
Sbjct: 803 KAQEEMISELRQQKFYL--ETQA----GKLEAQNRKLEEQ--LEKISHQDHSDKNRLLE- 853
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
L ++L + LE E+ K ++ E+Q + + Q Q + LE +++
Sbjct: 854 LETRL------REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAA--LESQLR 905
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT--INYEN- 448
+ K L+ T ++ ++E+ L +DE+ KF+ + T+ +L E+ + +N
Sbjct: 906 QAKTELEETT---AEAEEEIQALTAHRDEIQ-RKFDALRNSCTVITDLEEQLNQLTEDNA 961
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E N N + K + E + + R V L + E + +L + ++ L + +
Sbjct: 962 ELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 1021
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
LE ++ + LN+ + E + EA ++L + + E V ++ + + EK+
Sbjct: 1022 LEEQVMDLE-ALNDELLEKERQWEAWRSVLGDEKSQ-------FECRVRELQRMLDTEKQ 1073
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRV 628
+ E + VEL KE ++I L++ ++++++ E
Sbjct: 1074 SRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKHA 1129
Query: 629 LLAQAAADL-SRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
+L A L +LE E E L ++ L + LT + + D LK
Sbjct: 1130 MLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKT 1189
Query: 688 DLEQSQYTPKSPSVLRKSLKVGKE 711
+ +Y ++ VL KV E
Sbjct: 1190 ERSDLEYQLENIQVLYSHEKVKME 1213
Score = 62.1 bits (144), Expect = 7e-09
Identities = 78/349 (22%), Positives = 155/349 (44%), Gaps = 37/349 (10%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHT 176
Q E + + + EI L E+ KF N+ +++ +L++L +N +
Sbjct: 906 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 965
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
+ N ++ S ND I++L + + L E+ +++M+L+S ++ + + C
Sbjct: 966 Q-NFYLSKQLDEASGA-ND---EIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT 1020
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
L+E++ E A + LE + A + + +++ + L+ LD EKQ
Sbjct: 1021 MLEEQVMDLE---ALNDELLEKERQWEAWRSVLGDE-KSQFECRVRELQRMLDTEKQ--- 1073
Query: 297 SKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE 356
S+ + DQ + + + L + K + AL+Q +KEQ++KA ES S+
Sbjct: 1074 SRARADQ---RITESRQVVELAVKEHKAEILALQQ-----ALKEQKLKA------ESLSD 1119
Query: 357 KLKICE---IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
KL E E ++S+Q+ + + Q L +E +L+ +DL N L Q L
Sbjct: 1120 KLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 1179
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
+ D L TE+ + +++ ++ + Y +EK K+ + + K
Sbjct: 1180 ALDRADLLKTERSDLEYQLENIQ-------VLYSHEKVKMEGTISQQTK 1221
Score = 55.2 bits (127), Expect = 8e-07
Identities = 81/361 (22%), Positives = 161/361 (44%), Gaps = 40/361 (11%)
Query: 195 DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ 254
D ++ +EKK E+ D Q + +E+ +T L +++ E L++ +
Sbjct: 439 DSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMT-------RLHRRVSEVEAVLSQKEV 491
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
L+ + +L E Y E +LK L++ + + + D + L+ H+
Sbjct: 492 ELKASETQRSLL----EQDLATYITECSSLKRSLEQARMEVSQE---DDKALQLLHDIRE 544
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE---SASEKLKICEIQFEERSQS 371
+S K Q +KE ++ +Q+ +EM+ + Q+EE SA + + E + E +
Sbjct: 545 QSRKLQEIKE-----QEYQAQV----EEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 595
Query: 372 IQEHCSQ----QEKTIQYLEQEIKEL-KYTLDLTNNQNSDLK-QELNNLKNCKDELSTEK 425
+E + Q K ++ +Q E+ +Y N LK QEL + STE
Sbjct: 596 AEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEA 655
Query: 426 FNFIEEIKTLKDEL---IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
++ I+ K+ +EK N E +E + L + ++EK++ E +S VH
Sbjct: 656 TELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHR-EAQVSAQHLEVH- 713
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS 540
L + + + +++ L++Q++ + KE LEN + ++ + + E K A++N + S
Sbjct: 714 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQK-AMINAMDS 772
Query: 541 K 541
K
Sbjct: 773 K 773
>AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens
cDNA FLJ14957 fis, clone PLACE4000009, weakly similar to
MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B. ).
Length = 612
Score = 76.2 bits (179), Expect = 4e-13
Identities = 86/423 (20%), Positives = 192/423 (45%), Gaps = 24/423 (5%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
QD+L + D K E IE+ LQ++L +A + R+ + +
Sbjct: 14 QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLL--IAKEGREDL----LRKRE 67
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
R+L+ L+ + H+ E+ A + +R + E K E L + + +
Sbjct: 68 RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQ 127
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
+ E + + + LQ + E +A+ Q+++E +KG A A E + E +
Sbjct: 128 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE 187
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC-------EALEQLHS 334
EAL EEK+A+ ++ ++ E + N S + + + L EK E L +L +
Sbjct: 188 EALVHVRKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKN 247
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
++ + + +E++++ ++ ++ E + E+ + + + +++++KE
Sbjct: 248 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 307
Query: 395 YTLD---LTNNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ LT + D +++EL + + +DE T++ + +K L+ EL K+ + +
Sbjct: 308 LEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLK 366
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+++++L +E + ++ E L R+ +LT R+ S ++EQL +++ +A++
Sbjct: 367 DDRSRLVKQMEDKV---SQLEMELEEERNNSDLLTERISRSREQMEQLRNELLQERAARQ 423
Query: 508 VLE 510
LE
Sbjct: 424 DLE 426
Score = 50.4 bits (115), Expect = 2e-05
Identities = 98/435 (22%), Positives = 189/435 (43%), Gaps = 52/435 (11%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
+S +R E AL +L + KQ + + K +E+L K + +LK LKE+ +
Sbjct: 25 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGA-LKEEVSS 83
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
+Q +L KEQ A+L+ + ES E K E+ RS + ++ + E ++ L++
Sbjct: 84 HDQEMDKL--KEQ-YDAELQALRESVEEATKNVEV-LASRSNTSEQDQAGTEMRVKLLQE 139
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
E ++L+ + + + L++++ +LK DE ++ TLK YE
Sbjct: 140 ENEKLQGRSEELERRVAQLQRQIEDLKG--DEAKAKE--------TLK--------KYEG 181
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E +L A+ KE+ + ++ + + L ++ E +QL ++++ + KE
Sbjct: 182 EIRQLEEALVHVRKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE- 240
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+L KN + N + + ++ K+ L KE I+E + T LQN + +
Sbjct: 241 ---QLRRLKNEMEN-----ERW-----HLGKTIEKLQKEMADIVEASRTSTLELQN-QLD 286
Query: 569 AYRELGTIKNELIEDVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
Y+E + EL E LK+++ + + +++ L E
Sbjct: 287 EYKEKN--RRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTK 344
Query: 627 RVLLAQAAADL-------SRLENENERYXXXXXXXXS-LVVELSLLRQENEELTMTVAKQ 678
R LL Q DL S L+++ R S L +EL R ++ LT +++
Sbjct: 345 RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLTERISRS 404
Query: 679 SSIIDKLKKDLEQSQ 693
+++L+ +L Q +
Sbjct: 405 REQMEQLRNELLQER 419
Score = 44.4 bits (100), Expect = 0.001
Identities = 64/321 (19%), Positives = 139/321 (43%), Gaps = 29/321 (9%)
Query: 104 ELVQAQDVEIRNKDQT-ICEYNKQIEDYKN----EIAQLQEILKELATKFRQSHNNI--- 155
E +Q + +I +T E Q+++YK E+A++Q LKE + +S
Sbjct: 261 EKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 320
Query: 156 --DFNEIDRKLSKLRINNTNCHTEHNAVQGT--DAE---KVSAMINDMRSRII-ELEKKC 207
++ +L + T+ ++ T D E + + + D RSR++ ++E K
Sbjct: 321 QDGMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKV 380
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
L+ E+ +++ +++T R S ++ E+L + L +Q LE K ++L
Sbjct: 381 SQLEMELEEERNN----SDLLTERISRSREQMEQLRNELLQERAARQDLECDK----ISL 432
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
E ++ K + L+ K+ ++ + + L+ + + N L +
Sbjct: 433 ERQN---KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNR-- 487
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
LE+ +L+++ + L ++ S +LK + Q EE + I S ++K + LE
Sbjct: 488 RLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 547
Query: 388 QEIKELKYTLDLTNNQNSDLK 408
+++ ++ N+ DL+
Sbjct: 548 EQMDMNEHLQGQLNSMKKDLR 568
Score = 43.2 bits (97), Expect = 0.003
Identities = 55/285 (19%), Positives = 140/285 (49%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 293 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQL-LEQT 351
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 352 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER----NNSDLLTERI-SRSRE 406
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E L+N++L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 407 QMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 466
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 467 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 526
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 527 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 570
Score = 41.5 bits (93), Expect = 0.010
Identities = 56/270 (20%), Positives = 117/270 (43%), Gaps = 18/270 (6%)
Query: 338 IKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTL 397
++ ++ + ++ +++ SE E+ +RS+ +E + E+ +Q +Q++++L
Sbjct: 1 MEREQHQTEIRDLQDQLSEMHD--ELDSAKRSED-REKGALIEELLQ-AKQDLQDLLIAK 56
Query: 398 DLTNNQNSDLKQELNNLKNC-KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
+ + ++EL LK K+E+S+ +E+ LK++ + +
Sbjct: 57 EGREDLLRKRERELTALKGALKEEVSSHD----QEMDKLKEQYDAELQALRESVEEATKN 112
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
VE N E + T V +L + E+LE +V L E L+ +
Sbjct: 113 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA 172
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K TL E + +EALV++ K + R +E+ +E+ Q + +E +
Sbjct: 173 KETLKKYEGEIRQLEEALVHVRKEEKEAVSAR-RALENE---LEAAQGNLSQTTQEQKQL 228
Query: 577 KNELIEDVELLKKESNSQIKFLREEVEKKR 606
+L E+ E Q++ L+ E+E +R
Sbjct: 229 SEKLKEE-----SEQKEQLRRLKNEMENER 253
>AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein.
Length = 1559
Score = 76.2 bits (179), Expect = 4e-13
Identities = 97/476 (20%), Positives = 211/476 (44%), Gaps = 36/476 (7%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
SS+K++L + ++ +D+ +IR + + + E +Q +Y+ ++ +++ ++ +L
Sbjct: 63 SSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLE 120
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTDAEKVSAMINDMRSRI 200
+ D E + + S+L T C +H ++ D K
Sbjct: 121 EDLVSARRRSDLYESELRESRLAAEEFKRKATEC--QHKLLKAKDQGKPEV------GEY 172
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LEK ++ + Q +L + T L +++++ E L + Q R + +
Sbjct: 173 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSE 232
Query: 261 GHHALALEANE--SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
G +EA E RE ++ + L+ L +++Q K KV +K K A E+L+
Sbjct: 233 GIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK-KDLADKETLE 291
Query: 319 NQMLKEKCEALEQ--LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHC 376
N M + + EA E+ + S+ M +K+ +E+ E + ++ S Q +
Sbjct: 292 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS-SLFTQRNM 350
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
QE+ I L Q+ L+ QN L+++L + + +D ++K +E L+
Sbjct: 351 KAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH-QDH--SDKNRLLE----LE 403
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE--- 493
L E ++ +E +K +L + + + E+ L+ + L +LR++ +ELE
Sbjct: 404 TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 463
Query: 494 -QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEH 548
+ E+++Q LT+ ++ ++ + + L N+ + +E L + + A L ++
Sbjct: 464 AEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQN 515
Score = 65.3 bits (152), Expect = 7e-10
Identities = 88/377 (23%), Positives = 162/377 (42%), Gaps = 33/377 (8%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHT 176
Q E + + + EI L E+ KF N+ +++ +L++L +N +
Sbjct: 454 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 513
Query: 177 EHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
+ N ++ S ND I++L + + L E+ +++M+L+S ++ + + C
Sbjct: 514 Q-NFYLSKQLDEASGA-ND---EIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT 568
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
L+E++ E A + LE + A + + +++ + L+ LD EKQ
Sbjct: 569 MLEEQVMDLE---ALNDELLEKERQWEAWRSVLGDE-KSQFECRVRELQRMLDTEKQ--- 621
Query: 297 SKCKVDQENLKTK---------HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
S+ + DQ +++ H A I +L+ Q LKE+ E L +L E++ A L
Sbjct: 622 SRARADQRITESRQVVELAVKEHKAEILALQ-QALKEQKLKAESLSDKLNDLEKK-HAML 679
Query: 348 EQIEESASEKLKI---CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN 404
E S +KL+ + + E +Q+ Q+ I L Q ++E DL +
Sbjct: 680 EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER 739
Query: 405 SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK------NKLNLAVE 458
SDL+ +L N++ + I + L D L K +K N+L LA+E
Sbjct: 740 SDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKVPLQYNELKLALE 799
Query: 459 KAIKEKNKFETSLSVTR 475
K + E +L TR
Sbjct: 800 KEKARCAELEEALQKTR 816
Score = 64.5 bits (150), Expect = 1e-09
Identities = 112/564 (19%), Positives = 233/564 (41%), Gaps = 48/564 (8%)
Query: 155 IDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE---LEKKCEALD 211
++ E++ K + +++ + + EK+ + N ++ + + LE + +
Sbjct: 239 VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE 298
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
E ++K LS + +I DS + L++++ L+E + + + +L + N
Sbjct: 299 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVE----LSEANK----LAANSSLFTQRNM 350
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
+ E EL K L E QA K++ +N K + +E + +Q +K LE
Sbjct: 351 KAQEEMISELRQQKFYL--ETQA----GKLEAQNRKLEEQ--LEKISHQDHSDKNRLLE- 401
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
L ++L + LE E+ K ++ E+Q + + Q Q + LE +++
Sbjct: 402 LETRL------REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAA--LESQLR 453
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT--INYEN- 448
+ K L+ T ++ ++E+ L +DE+ KF+ + T+ +L E+ + +N
Sbjct: 454 QAKTELEETT---AEAEEEIQALTAHRDEIQ-RKFDALRNSCTVITDLEEQLNQLTEDNA 509
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E N N + K + E + + R V L + E + +L + ++ L + +
Sbjct: 510 ELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 569
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
LE ++ + LN+ + E + EA ++L + + E V ++ + + EK+
Sbjct: 570 LEEQVMDLE-ALNDELLEKERQWEAWRSVLGDEKSQ-------FECRVRELQRMLDTEKQ 621
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRV 628
+ E + VEL KE ++I L++ ++++++ E
Sbjct: 622 SRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKHA 677
Query: 629 LLAQAAADL-SRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
+L A L +LE E E L ++ L + LT + + D LK
Sbjct: 678 MLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKT 737
Query: 688 DLEQSQYTPKSPSVLRKSLKVGKE 711
+ +Y ++ VL KV E
Sbjct: 738 ERSDLEYQLENIQVLYSHEKVKME 761
>Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9,
non-muscle protein.
Length = 1960
Score = 75.8 bits (178), Expect = 5e-13
Identities = 103/514 (20%), Positives = 226/514 (43%), Gaps = 39/514 (7%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ-EKLTSN 245
+++ + +D+ +R+ E E++C+ L E Q + LEE + +S + LQ EK+T
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT-- 968
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKI---ELEALKTKLDEEKQAIISKCKVD 302
T+ +L+ ++ + + N + +E K+ + T L EE++ S K
Sbjct: 969 ------TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-- 1020
Query: 303 QENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
LK KH A I L+ ++ +E + + LE+ +L ++ ++ +++ +E
Sbjct: 1021 ---LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE---- 1073
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++Q ++ + +Q ++ E+ +K+++ +Q S+L+++L + + +++
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNK 1129
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
+K + EE++ LK EL E T++ + +L E+ + K + T + +
Sbjct: 1130 AEKQKRDLGEELEALKTEL-EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-AQI 1187
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE-CDEYKEALVNILK 539
+R + S + +E+L +Q++ K LE K TL N E +E K L
Sbjct: 1188 QEMRQKHSQA-VEELAEQLEQTKRVKANLEKA----KQTLENERGELANEVKVLLQGKGD 1242
Query: 540 SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
S+ K ++ E V E + V E ++ ++ EL LL + + K +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEG-ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 600 E--EVEKK-RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXS 656
+ +E + + E+ + + + + +LE E E +
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 657 LVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L +++ ++++ E+ + + KL+KDLE
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Score = 75.8 bits (178), Expect = 5e-13
Identities = 105/517 (20%), Positives = 234/517 (45%), Gaps = 32/517 (6%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKN--EIAQLQEILKELATKFRQSHNNI 155
++ ++E Q E + Q I E +Q+E+ ++ + QL+++ E K + I
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQI 981
Query: 156 DFNEIDRKLSKLR--INNTNCHTEHNAVQGTDAEKVSAMI-NDMRSRIIELEKKCEALDN 212
+ + KL+K + + + N + + K A + N + I +LE++ +
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALEANE 271
+ + + LE T +LQ ++ ++ LA+ ++ L+ A + N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 272 SIR--REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCE 327
+++ RE + ++ L+ L+ E+ S+ K +++ K +E+LK ++ +
Sbjct: 1102 ALKKIRELESQISELQEDLESER---ASRNKAEKQ--KRDLGEELEALKTELEDTLDSTA 1156
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESA-SEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
A ++L S+ +EQE+ + +EE A + + +I E++ ++ SQ+++E Q E+T + +
Sbjct: 1157 AQQELRSK---REQEVNILKKTLEEEAKTHEAQIQEMR-QKHSQAVEELAEQLEQT-KRV 1211
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
+ +++ K TL+ N+ +L E+ L K + ++ ++++ EL K
Sbjct: 1212 KANLEKAKQTLE---NERGELANEVKVLLQGKGDSEHKR----KKVEAQLQELQVKFNEG 1264
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
E + +L V K E + LS + LT +S+L+ ++ +Q K
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL---TKEHTRIMEHNVTLIESLQ 563
L +L ++ N+ + +E +EA N+ K A L + + ME +V +E+ +
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLRE 600
V+++ ++L + E V K ++ + +E
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Score = 68.1 bits (159), Expect = 1e-10
Identities = 102/531 (19%), Positives = 226/531 (42%), Gaps = 26/531 (4%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA 145
++K L + Q EL ++ E+ +T+ E K E E+ Q + ++ELA
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 146 TKFRQSHN-NIDFNEIDRKLSKLR---INNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q+ + + + L R N + +KV A + +++ +
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E E+ L ++V Q+EL ++ +++ DS L + ++ E L +TQ+ L+ +
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE-EN 1321
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
L+L ++ + E + + +L+EE++A K ++++ + T H A + +K +M
Sbjct: 1322 RQKLSLSTK---LKQVEDEKNSFREQLEEEEEA---KHNLEKQ-IATLH-AQVADMKKKM 1373
Query: 322 LKEK-C-EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ 379
C E E++ +L K+ E ++ + + +A +KL+ + + ++ + Q
Sbjct: 1374 EDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
++ LE++ K+ L ++ +E + + E T+ + + +E
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL----EEA 1488
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
+E+ E + +E + K+ S+ L ++ E ++LE+LED++
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 500 QMLTSAKEVLENEL----TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
Q AK LE L ++ L + +E K+ LV ++ A ++ +
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
V + L+ K+ + + E ++ L+K +Q+K E++ R
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTR 1658
Score = 66.5 bits (155), Expect = 3e-10
Identities = 70/317 (22%), Positives = 144/317 (45%), Gaps = 17/317 (5%)
Query: 300 KVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESASE 356
KV ++ L ++ + +E+L++Q++ EK + EQL ++ L + +E++A+L ++ E
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 357 KLKICEIQFEE---RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
E + EE R Q +Q + ++ IQ LE++++E + + + +L
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L+ + L + +E K L+D + E T N E+ K + K KNK E ++
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK----SKSLAKLKNKHEAMITD 1031
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ + + +E + +LE L+ L+ ++ K L ++ +E + A
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQAA 1088
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKES 591
L + + A +I E + E +++E E + + K +L E++E LK E
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 592 NSQI--KFLREEVEKKR 606
+ ++E+ KR
Sbjct: 1149 EDTLDSTAAQQELRSKR 1165
Score = 60.9 bits (141), Expect = 2e-08
Identities = 83/373 (22%), Positives = 161/373 (43%), Gaps = 31/373 (8%)
Query: 124 NKQIEDYKNEIA-QLQEILKELATKFRQSHNNIDFN---EIDRKLSKLRINNTNCHTEHN 179
++Q E+ K ++ Q++E+ EL + +Q + E+D K + I++ N + +
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q K+ A + D + + E + + + + +L S+E + LQ
Sbjct: 1637 IKQ---LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI-------QLQ 1686
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
E+L + E + QQ + + A + ++ E K LEA +L+EE +
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEAL--EQLHSQLIIKEQEMKAKLEQIEESASEK 357
++ + LK K N I+ + + E+ A E QL + +E+K KL+++E + K
Sbjct: 1746 ELINDRLK-KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
K E + ++E + K Q ++++ + L Q D ++ K+
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRD 476
D+ ST +K LK +L E E E + N + K +E ++ ET+ ++ R+
Sbjct: 1865 ADKAST-------RLKQLKRQLEEA----EEEAQRANASRRKLQRELEDATETADAMNRE 1913
Query: 477 IVHVLTLRLRESD 489
V L +LR D
Sbjct: 1914 -VSSLKNKLRRGD 1925
Score = 57.6 bits (133), Expect = 1e-07
Identities = 84/425 (19%), Positives = 181/425 (42%), Gaps = 30/425 (7%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNA- 180
+ K + + + L++ ++E+ T+ + + + E D KL +L +N +
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKL-RLEVNLQAMKAQFERD 1572
Query: 181 VQGTDA---EKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLEEVITVRDSL 234
+QG D EK ++ +R ELE + + V + +M+L LE I +
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKG-HHALALEANESIRREYKIELEALKTKLDEEKQ 293
+ ++L + + + + L+ + + +A E+ ++ +E E ++ + +E
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAA 1691
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
A +K + QE + + S K + E+ LE +QL + +E + E I
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI--- 1748
Query: 354 ASEKLKICEIQFEERSQSI---QEHCSQQEKTIQYLEQEIKELKYTL-DLTNNQNSDLKQ 409
+++LK +Q ++ + + + H + E Q LE++ KELK L ++ S K
Sbjct: 1749 -NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
+ L+ +L + N +E + + + +T E + + L V+ + ++
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQ-VRRT---EKKLKDVLLQVDDERRNAEQY-- 1861
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
+D + RL++ +LE+ E++ Q +++ L+ EL T + RE
Sbjct: 1862 -----KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 530 YKEAL 534
K L
Sbjct: 1917 LKNKL 1921
Score = 57.2 bits (132), Expect = 2e-07
Identities = 131/694 (18%), Positives = 289/694 (41%), Gaps = 70/694 (10%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K KA K+TL + ++ + +++ + +K + + ++++ NE +++
Sbjct: 1209 KRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR 1268
Query: 139 EILKELATKFRQSHNNID--FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
L + TK + +N+ ++ D K SKL + + ++ Q E+ ++ +
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS-L 1327
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ-R 255
+++ ++E + + ++ +++ +LE+ I + D+++K+ + L ++ +
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE---NLKTKHNA 312
++ K L+ E + K LE KT+L +E ++ ++ NL+ K
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDK--LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQ 370
+ L + A E+ ++ +E+E KA +EE+ +K ++ + + R++
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 371 ---------SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ---NSDLKQELN-NLKNC 417
+ + + EK+ + LEQ+++E+K L+ ++ D K L NL+
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 418 KDELSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLAV------EKAIKEKNKF 467
K + + E+ + K +L+ E E+E+ + ++AV E +K+
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 468 ETSLSVTRD--IVHVLTLRLRESDSELEQLED----QVQMLTSAKE-------------V 508
S + RD I + L+ + D + +L+D + ++L AKE
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDC-MRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQ---- 563
L+ EL + +E DE + + N K AL E R +E + L E L+
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 564 NVE------KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
N E K+A ++ I +L + +K N++ + R+ E K L EM
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENE----RYXXXXXXXXSLVVELSLLRQENEELTM 673
+AQ L E + + +++++ R+ E+
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 674 TVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
K S+ + +LK+ LE+++ + + R+ L+
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
>CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein.
Length = 1960
Score = 75.8 bits (178), Expect = 5e-13
Identities = 103/514 (20%), Positives = 226/514 (43%), Gaps = 39/514 (7%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ-EKLTSN 245
+++ + +D+ +R+ E E++C+ L E Q + LEE + +S + LQ EK+T
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT-- 968
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKI---ELEALKTKLDEEKQAIISKCKVD 302
T+ +L+ ++ + + N + +E K+ + T L EE++ S K
Sbjct: 969 ------TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-- 1020
Query: 303 QENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
LK KH A I L+ ++ +E + + LE+ +L ++ ++ +++ +E
Sbjct: 1021 ---LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE---- 1073
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++Q ++ + +Q ++ E+ +K+++ +Q S+L+++L + + +++
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNK 1129
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
+K + EE++ LK EL E T++ + +L E+ + K + T + +
Sbjct: 1130 AEKQKRDLGEELEALKTEL-EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-AQI 1187
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE-CDEYKEALVNILK 539
+R + S + +E+L +Q++ K LE K TL N E +E K L
Sbjct: 1188 QEMRQKHSQA-VEELAEQLEQTKRVKANLEKA----KQTLENERGELANEVKVLLQGKGD 1242
Query: 540 SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
S+ K ++ E V E + V E ++ ++ EL LL + + K +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEG-ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 600 E--EVEKK-RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXS 656
+ +E + + E+ + + + + +LE E E +
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 657 LVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L +++ ++++ E+ + + KL+KDLE
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Score = 75.8 bits (178), Expect = 5e-13
Identities = 105/517 (20%), Positives = 234/517 (45%), Gaps = 32/517 (6%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKN--EIAQLQEILKELATKFRQSHNNI 155
++ ++E Q E + Q I E +Q+E+ ++ + QL+++ E K + I
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQI 981
Query: 156 DFNEIDRKLSKLR--INNTNCHTEHNAVQGTDAEKVSAMI-NDMRSRIIELEKKCEALDN 212
+ + KL+K + + + N + + K A + N + I +LE++ +
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALEANE 271
+ + + LE T +LQ ++ ++ LA+ ++ L+ A + N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 272 SIR--REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCE 327
+++ RE + ++ L+ L+ E+ S+ K +++ K +E+LK ++ +
Sbjct: 1102 ALKKIRELESQISELQEDLESER---ASRNKAEKQ--KRDLGEELEALKTELEDTLDSTA 1156
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESA-SEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
A ++L S+ +EQE+ + +EE A + + +I E++ ++ SQ+++E Q E+T + +
Sbjct: 1157 AQQELRSK---REQEVNILKKTLEEEAKTHEAQIQEMR-QKHSQAVEELAEQLEQT-KRV 1211
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
+ +++ K TL+ N+ +L E+ L K + ++ ++++ EL K
Sbjct: 1212 KANLEKAKQTLE---NERGELANEVKVLLQGKGDSEHKR----KKVEAQLQELQVKFNEG 1264
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
E + +L V K E + LS + LT +S+L+ ++ +Q K
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL---TKEHTRIMEHNVTLIESLQ 563
L +L ++ N+ + +E +EA N+ K A L + + ME +V +E+ +
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLRE 600
V+++ ++L + E V K ++ + +E
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Score = 68.1 bits (159), Expect = 1e-10
Identities = 102/531 (19%), Positives = 226/531 (42%), Gaps = 26/531 (4%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA 145
++K L + Q EL ++ E+ +T+ E K E E+ Q + ++ELA
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 146 TKFRQSHN-NIDFNEIDRKLSKLR---INNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q+ + + + L R N + +KV A + +++ +
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E E+ L ++V Q+EL ++ +++ DS L + ++ E L +TQ+ L+ +
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE-EN 1321
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
L+L ++ + E + + +L+EE++A K ++++ + T H A + +K +M
Sbjct: 1322 RQKLSLSTK---LKQVEDEKNSFREQLEEEEEA---KHNLEKQ-IATLH-AQVADMKKKM 1373
Query: 322 LKEK-C-EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ 379
C E E++ +L K+ E ++ + + +A +KL+ + + ++ + Q
Sbjct: 1374 EDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
++ LE++ K+ L ++ +E + + E T+ + + +E
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL----EEA 1488
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
+E+ E + +E + K+ S+ L ++ E ++LE+LED++
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 500 QMLTSAKEVLENEL----TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
Q AK LE L ++ L + +E K+ LV ++ A ++ +
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
V + L+ K+ + + E ++ L+K +Q+K E++ R
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTR 1658
Score = 66.5 bits (155), Expect = 3e-10
Identities = 70/317 (22%), Positives = 144/317 (45%), Gaps = 17/317 (5%)
Query: 300 KVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESASE 356
KV ++ L ++ + +E+L++Q++ EK + EQL ++ L + +E++A+L ++ E
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 357 KLKICEIQFEE---RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
E + EE R Q +Q + ++ IQ LE++++E + + + +L
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L+ + L + +E K L+D + E T N E+ K + K KNK E ++
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK----SKSLAKLKNKHEAMITD 1031
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ + + +E + +LE L+ L+ ++ K L ++ +E + A
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQAA 1088
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKES 591
L + + A +I E + E +++E E + + K +L E++E LK E
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 592 NSQI--KFLREEVEKKR 606
+ ++E+ KR
Sbjct: 1149 EDTLDSTAAQQELRSKR 1165
Score = 60.9 bits (141), Expect = 2e-08
Identities = 83/373 (22%), Positives = 161/373 (43%), Gaps = 31/373 (8%)
Query: 124 NKQIEDYKNEIA-QLQEILKELATKFRQSHNNIDFN---EIDRKLSKLRINNTNCHTEHN 179
++Q E+ K ++ Q++E+ EL + +Q + E+D K + I++ N + +
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q K+ A + D + + E + + + + +L S+E + LQ
Sbjct: 1637 IKQ---LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI-------QLQ 1686
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
E+L + E + QQ + + A + ++ E K LEA +L+EE +
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEAL--EQLHSQLIIKEQEMKAKLEQIEESASEK 357
++ + LK K N I+ + + E+ A E QL + +E+K KL+++E + K
Sbjct: 1746 ELINDRLK-KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
K E + ++E + K Q ++++ + L Q D ++ K+
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRD 476
D+ ST +K LK +L E E E + N + K +E ++ ET+ ++ R+
Sbjct: 1865 ADKAST-------RLKQLKRQLEEA----EEEAQRANASRRKLQRELEDATETADAMNRE 1913
Query: 477 IVHVLTLRLRESD 489
V L +LR D
Sbjct: 1914 -VSSLKNKLRRGD 1925
Score = 57.6 bits (133), Expect = 1e-07
Identities = 84/425 (19%), Positives = 181/425 (42%), Gaps = 30/425 (7%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNA- 180
+ K + + + L++ ++E+ T+ + + + E D KL +L +N +
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKL-RLEVNLQAMKAQFERD 1572
Query: 181 VQGTDA---EKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLEEVITVRDSL 234
+QG D EK ++ +R ELE + + V + +M+L LE I +
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKG-HHALALEANESIRREYKIELEALKTKLDEEKQ 293
+ ++L + + + + L+ + + +A E+ ++ +E E ++ + +E
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAA 1691
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
A +K + QE + + S K + E+ LE +QL + +E + E I
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI--- 1748
Query: 354 ASEKLKICEIQFEERSQSI---QEHCSQQEKTIQYLEQEIKELKYTL-DLTNNQNSDLKQ 409
+++LK +Q ++ + + + H + E Q LE++ KELK L ++ S K
Sbjct: 1749 -NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
+ L+ +L + N +E + + + +T E + + L V+ + ++
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQ-VRRT---EKKLKDVLLQVDDERRNAEQY-- 1861
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
+D + RL++ +LE+ E++ Q +++ L+ EL T + RE
Sbjct: 1862 -----KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 530 YKEAL 534
K L
Sbjct: 1917 LKNKL 1921
Score = 57.2 bits (132), Expect = 2e-07
Identities = 131/694 (18%), Positives = 289/694 (41%), Gaps = 70/694 (10%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K KA K+TL + ++ + +++ + +K + + ++++ NE +++
Sbjct: 1209 KRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR 1268
Query: 139 EILKELATKFRQSHNNID--FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
L + TK + +N+ ++ D K SKL + + ++ Q E+ ++ +
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS-L 1327
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ-R 255
+++ ++E + + ++ +++ +LE+ I + D+++K+ + L ++ +
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE---NLKTKHNA 312
++ K L+ E + K LE KT+L +E ++ ++ NL+ K
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDK--LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQ 370
+ L + A E+ ++ +E+E KA +EE+ +K ++ + + R++
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 371 ---------SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ---NSDLKQELN-NLKNC 417
+ + + EK+ + LEQ+++E+K L+ ++ D K L NL+
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 418 KDELSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLAV------EKAIKEKNKF 467
K + + E+ + K +L+ E E+E+ + ++AV E +K+
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 468 ETSLSVTRD--IVHVLTLRLRESDSELEQLED----QVQMLTSAKE-------------V 508
S + RD I + L+ + D + +L+D + ++L AKE
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDC-MRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQ---- 563
L+ EL + +E DE + + N K AL E R +E + L E L+
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 564 NVE------KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
N E K+A ++ I +L + +K N++ + R+ E K L EM
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENE----RYXXXXXXXXSLVVELSLLRQENEELTM 673
+AQ L E + + +++++ R+ E+
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 674 TVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
K S+ + +LK+ LE+++ + + R+ L+
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
>BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein
protein.
Length = 1694
Score = 75.8 bits (178), Expect = 5e-13
Identities = 116/575 (20%), Positives = 253/575 (44%), Gaps = 59/575 (10%)
Query: 190 SAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTL 249
S +I S+I E++K + L E + ++ LE+ I KD+ +KL+S E
Sbjct: 21 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKI-------KDINKKLSSAENDR 73
Query: 250 AETQQRLEMVKGHHALALEANESIRREY-KIELEALK-TKLDEEKQAIISKCKVDQENLK 307
++ E + +E E+++ E K++ A+K + EK+ I+++ +E +
Sbjct: 74 DILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFR 133
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLII--KEQEMKAKLEQIEESASEKLKICEIQF 365
+ ++ +N++++ E+L L+ E E+ + S +L +
Sbjct: 134 LQQ--ALSDAENEIMRLSSLNQEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNL 191
Query: 366 EERSQSIQEHCSQQEKTIQYLE----QEIKELKYTL----DLTNNQN------SDLKQEL 411
E + Q + + S++E I +E Q + K+ + L+ QN S LKQ+L
Sbjct: 192 EAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDL 251
Query: 412 NNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN---EKNKLNLAVEKAIKEKNKF- 467
N+ K +L +K + +E+ K++LI+ + + K KL VE + + NK
Sbjct: 252 NDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQ 311
Query: 468 ETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL-NNTVRE 526
E+++S+ ++ + L +R+++ EL ++ +++ + + ++ + +K+TL E
Sbjct: 312 ESNVSIQKENLE-LKEHIRQNEEELSRIRNELM-----QSLNQDSNSNFKDTLLKEREAE 365
Query: 527 CDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE------AYRELGTIKNEL 580
K+ L + + L K + N L+ + ++V + +L KN +
Sbjct: 366 VRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTI 425
Query: 581 IEDVELLKKESNSQI----KFLREEVEK-KRVLCEMXXXXXXXXXXXXXXSRVLLA---Q 632
+E +++ K E +++ K L EE K ++ + E+ L+ +
Sbjct: 426 VETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQK 485
Query: 633 AAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLK-KDLEQ 691
+++ L+ E+ + LS +E ++LT + K+ I+KLK + +
Sbjct: 486 KDMEIAELKKNIEQMDTDHKETKDV---LSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 542
Query: 692 SQYTPKSPSVLRKS---LKVGKENMQTISPLRERN 723
+ K LRK+ + +E +++ ++E N
Sbjct: 543 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 577
Score = 66.5 bits (155), Expect = 3e-10
Identities = 111/566 (19%), Positives = 237/566 (41%), Gaps = 41/566 (7%)
Query: 102 QDELVQA--QDVEIRNKDQTICEYNKQIEDYK---NEIAQLQEILKELATKFRQSHNNID 156
++EL+Q+ QD KD + E ++ + K +E+ QL E LK++A + + +
Sbjct: 339 RNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLV 398
Query: 157 F--NEIDRKLSKLRINNTNCHTEHNAVQGT---DAEKVSAMINDMRSRIIELEKKCEALD 211
++ +L + N E N + T + ++ A + + R++E K E
Sbjct: 399 LACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI 458
Query: 212 NEVYD-KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
E+ + + + S+L+ + L K Q+K ++ +AE ++ +E + H +
Sbjct: 459 EELSNARNLNTSALQ---LEHEHLIKLNQKK----DMEIAELKKNIEQMDTDHKETKDVL 511
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL-KNQMLKEKCEAL 329
S E K +L T+L +K+ I K K L+ + + ++L KN++L++ E
Sbjct: 512 SSSLEEQK-QL----TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEK 566
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
++ + + ++ +LE++ E S + + + + + SQ ++LE+E
Sbjct: 567 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE 626
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
IK + ++ +QN Q L +L+ K E+ ++ + T +EK ++
Sbjct: 627 IKHHQKIIE---DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 683
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE--DQVQMLTSAKE 507
+ + + +E+ +T S V +L + E+ SE L + +++ KE
Sbjct: 684 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI-ENGSEKHDLSKAETERLVKGIKE 742
Query: 508 -VLENELTTYKN-TLNNTVREC--DEYKEALVNILKSKAALTKEHTRI--MEHNVTLIES 561
LE +L KN +L + + DE + I + + H RI H ++
Sbjct: 743 RELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYL 802
Query: 562 LQNVEKEAY--RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXX 619
Q ++ A ++ + NE + LK E + + + K+ L ++
Sbjct: 803 QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV---AAKEAALIKLQDENKKLS 859
Query: 620 XXXXXXSRVLLAQAAADLSRLENENE 645
+ + + +LSR+ E +
Sbjct: 860 TRFESSGQDMFRETIQNLSRIIREKD 885
Score = 58.0 bits (134), Expect = 1e-07
Identities = 83/403 (20%), Positives = 176/403 (43%), Gaps = 34/403 (8%)
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
ELS EE I ++L + + +L+ + EM K L +E ES ++
Sbjct: 1 ELSDYEERIEELENLLQQGGSGVIETDLS-----KIYEMQKTIQVLQIEKVESTKK---- 51
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL--- 336
+E L+ K+ + + + S + D++ L+ + +++ + + E+CE L+ S+L
Sbjct: 52 -MEQLEDKIKDINKKL-SSAENDRDILRREQEQL--NVEKRQIMEECENLKLECSKLQPS 107
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQ--FEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+K+ + + E+I ++ ++ +Q + I S ++ +Q ++
Sbjct: 108 AVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQEELQMSLLKLNNEY 167
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
+ T ++ L EL++L+ + E I E +TL E+ E + +
Sbjct: 168 EVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMI 227
Query: 455 LAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELT 514
L ++ K++N+ ++ I+ L L + + QLED +T +V + +L
Sbjct: 228 LIKDQLSKQQNEGDS-------IISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLI 280
Query: 515 TYKNTLNN---TVRECDEYKEALVNIL----KSKAALTKEHTRIMEHNVTLIESLQNVEK 567
+ LN+ T ++ ++ E LV+ L +S ++ KE+ + EH E L +
Sbjct: 281 QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN 340
Query: 568 EAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
E + L N +D L KE ++++ L++ + + L E
Sbjct: 341 ELMQSLNQDSNSNFKDT--LLKEREAEVRNLKQNLSELEQLNE 381
Score = 53.2 bits (122), Expect = 3e-06
Identities = 107/538 (19%), Positives = 233/538 (43%), Gaps = 47/538 (8%)
Query: 102 QDELVQAQD---VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
Q+EL Q Q V+ N + +Y I+ Y+ +L+ +ELA + + S + N
Sbjct: 958 QEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA-QVQHSIGQL-CN 1015
Query: 159 EIDRKLSKL-----RINNTNCHTEHNA--VQGTDAEKVSAMINDMRSRIIELEKKCEALD 211
D L KL ++++ + T +A ++ + +E +S ++ + EL K + D
Sbjct: 1016 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1075
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE--------MVKGHH 263
+ Q L + I L + E+ S L E Q L+ ++K
Sbjct: 1076 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1135
Query: 264 ALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK 323
L +NE+ + E E L+ + K+ I+ ++D LK ++ +E+ + + +
Sbjct: 1136 DQLLSSNENFTNKVN-ENELLRQAVTNLKERILI-LEMDIGKLKGENEKIVETYRGKETE 1193
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE--ERSQSIQEHCSQQEK 381
+ + ++++E+E + + + A E+L + Q + E +Q + S QEK
Sbjct: 1194 YQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1253
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
T+ + +QE ++ L +N+ L+ + L++ ++F +E++ L++ L+E
Sbjct: 1254 TVVF-QQERDQVMLALKQKQMENTALQNVVQRLRD-------KEFRSNQELERLRNHLLE 1305
Query: 442 KTINYENE----KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+Y E +++ +K + K +S + + H ++++ +L +
Sbjct: 1306 SEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSK 1365
Query: 498 QVQMLTSAKEVLENELTTYKNTLNN---TVRECDEYKEALVNI-LKSKAALTKEHTRIME 553
Q V + ++ Y +L N + + ++A+ + L+ + L E + E
Sbjct: 1366 QRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAE 1425
Query: 554 HNVTLIESLQNVEKEAYRELGT---IKNEL---IEDVELLKKESNSQIKFLREEVEKK 605
+ + SLQ EA L + + +L E +E LK+++ + + L ++V+KK
Sbjct: 1426 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEML-DDVQKK 1482
Score = 42.7 bits (96), Expect = 0.004
Identities = 111/563 (19%), Positives = 237/563 (42%), Gaps = 76/563 (13%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSA 191
EI LQ+ ++++ T+ + +I + D + +K++ N +E + + + E++
Sbjct: 679 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 738
Query: 192 MINDMRSRIIELEKKCEALDNEVYD-KQMELSSLEEVITVRDSLCKDLQEKLTSNELT-- 248
I + I L +K +L ++ + E+ L ++I +D + L +++S T
Sbjct: 739 GIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD 798
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK----CKVDQE 304
+ QQ+L+ +A+ E ++ E E LKT+ + + +K K+ E
Sbjct: 799 VVYLQQQLQA----YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 854
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQ 364
N K + ES M +E + L + II+E++++ ++ + + L + +
Sbjct: 855 NKKL--STRFESSGQDMFRETIQNLSR-----IIREKDIE--IDALSQKCQTLLAVLQTS 905
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
+++ + +Q E+ +Q + LKQ++ ++ K ++ T
Sbjct: 906 -STGNEAGGVNSNQFEELLQ------------------ERDTLKQQVKKMEEWKQQVMTT 946
Query: 425 KFNFIEEIKTLKDEL--IEKTINYENEKN-KLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
N E L++EL ++ + +++ N KL + I+ + ET
Sbjct: 947 VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET------------ 994
Query: 482 TLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK 541
+L+ EL Q++ + L + K++L +L L++ + E L SK
Sbjct: 995 --KLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECL---RASK 1049
Query: 542 AALTKEHTRIMEHNV-TLIESLQNVEKEA-YRELGTIKNELIEDV----ELLKKESNSQI 595
+ + E + +++ + L +SLQ EK+A R L + L + + EL +KE
Sbjct: 1050 SEVLSESSELLQQELEELRKSLQ--EKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1107
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE--RYXXXXXX 653
+++ EK+ VL ++ L + + + NENE R
Sbjct: 1108 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQ----LLSSNENFTNKVNENELLRQAVTNLK 1163
Query: 654 XXSLVVELSL--LRQENEELTMT 674
L++E+ + L+ ENE++ T
Sbjct: 1164 ERILILEMDIGKLKGENEKIVET 1186
>AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy
polypeptide 9 protein.
Length = 1960
Score = 75.8 bits (178), Expect = 5e-13
Identities = 103/514 (20%), Positives = 226/514 (43%), Gaps = 39/514 (7%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ-EKLTSN 245
+++ + +D+ +R+ E E++C+ L E Q + LEE + +S + LQ EK+T
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT-- 968
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKI---ELEALKTKLDEEKQAIISKCKVD 302
T+ +L+ ++ + + N + +E K+ + T L EE++ S K
Sbjct: 969 ------TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-- 1020
Query: 303 QENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
LK KH A I L+ ++ +E + + LE+ +L ++ ++ +++ +E
Sbjct: 1021 ---LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE---- 1073
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++Q ++ + +Q ++ E+ +K+++ +Q S+L+++L + + +++
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNK 1129
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
+K + EE++ LK EL E T++ + +L E+ + K + T + +
Sbjct: 1130 AEKQKRDLGEELEALKTEL-EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-AQI 1187
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE-CDEYKEALVNILK 539
+R + S + +E+L +Q++ K LE K TL N E +E K L
Sbjct: 1188 QEMRQKHSQA-VEELAEQLEQTKRVKANLEKA----KQTLENERGELANEVKVLLQGKGD 1242
Query: 540 SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
S+ K ++ E V E + V E ++ ++ EL LL + + K +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEG-ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 600 E--EVEKK-RVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXS 656
+ +E + + E+ + + + + +LE E E +
Sbjct: 1302 DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 657 LVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L +++ ++++ E+ + + KL+KDLE
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Score = 75.8 bits (178), Expect = 5e-13
Identities = 105/517 (20%), Positives = 234/517 (45%), Gaps = 32/517 (6%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKN--EIAQLQEILKELATKFRQSHNNI 155
++ ++E Q E + Q I E +Q+E+ ++ + QL+++ E K + I
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQI 981
Query: 156 DFNEIDRKLSKLR--INNTNCHTEHNAVQGTDAEKVSAMI-NDMRSRIIELEKKCEALDN 212
+ + KL+K + + + N + + K A + N + I +LE++ +
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALEANE 271
+ + + LE T +LQ ++ ++ LA+ ++ L+ A + N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 272 SIR--REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCE 327
+++ RE + ++ L+ L+ E+ S+ K +++ K +E+LK ++ +
Sbjct: 1102 ALKKIRELESQISELQEDLESER---ASRNKAEKQ--KRDLGEELEALKTELEDTLDSTA 1156
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESA-SEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
A ++L S+ +EQE+ + +EE A + + +I E++ ++ SQ+++E Q E+T + +
Sbjct: 1157 AQQELRSK---REQEVNILKKTLEEEAKTHEAQIQEMR-QKHSQAVEELAEQLEQT-KRV 1211
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
+ +++ K TL+ N+ +L E+ L K + ++ ++++ EL K
Sbjct: 1212 KANLEKAKQTLE---NERGELANEVKVLLQGKGDSEHKR----KKVEAQLQELQVKFNEG 1264
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
E + +L V K E + LS + LT +S+L+ ++ +Q K
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL---TKEHTRIMEHNVTLIESLQ 563
L +L ++ N+ + +E +EA N+ K A L + + ME +V +E+ +
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLRE 600
V+++ ++L + E V K ++ + +E
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Score = 68.1 bits (159), Expect = 1e-10
Identities = 102/531 (19%), Positives = 226/531 (42%), Gaps = 26/531 (4%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA 145
++K L + Q EL ++ E+ +T+ E K E E+ Q + ++ELA
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 146 TKFRQSHN-NIDFNEIDRKLSKLR---INNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q+ + + + L R N + +KV A + +++ +
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E E+ L ++V Q+EL ++ +++ DS L + ++ E L +TQ+ L+ +
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE-EN 1321
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
L+L ++ + E + + +L+EE++A K ++++ + T H A + +K +M
Sbjct: 1322 RQKLSLSTK---LKQVEDEKNSFREQLEEEEEA---KHNLEKQ-IATLH-AQVADMKKKM 1373
Query: 322 LKEK-C-EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ 379
C E E++ +L K+ E ++ + + +A +KL+ + + ++ + Q
Sbjct: 1374 EDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
++ LE++ K+ L ++ +E + + E T+ + + +E
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL----EEA 1488
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
+E+ E + +E + K+ S+ L ++ E ++LE+LED++
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 500 QMLTSAKEVLENEL----TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHN 555
Q AK LE L ++ L + +E K+ LV ++ A ++ +
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
V + L+ K+ + + E ++ L+K +Q+K E++ R
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTR 1658
Score = 66.5 bits (155), Expect = 3e-10
Identities = 70/317 (22%), Positives = 144/317 (45%), Gaps = 17/317 (5%)
Query: 300 KVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESASE 356
KV ++ L ++ + +E+L++Q++ EK + EQL ++ L + +E++A+L ++ E
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 357 KLKICEIQFEE---RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
E + EE R Q +Q + ++ IQ LE++++E + + + +L
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L+ + L + +E K L+D + E T N E+ K + K KNK E ++
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK----SKSLAKLKNKHEAMITD 1031
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ + + +E + +LE L+ L+ ++ K L ++ +E + A
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQAA 1088
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKES 591
L + + A +I E + E +++E E + + K +L E++E LK E
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 592 NSQI--KFLREEVEKKR 606
+ ++E+ KR
Sbjct: 1149 EDTLDSTAAQQELRSKR 1165
Score = 60.9 bits (141), Expect = 2e-08
Identities = 83/373 (22%), Positives = 161/373 (43%), Gaps = 31/373 (8%)
Query: 124 NKQIEDYKNEIA-QLQEILKELATKFRQSHNNIDFN---EIDRKLSKLRINNTNCHTEHN 179
++Q E+ K ++ Q++E+ EL + +Q + E+D K + I++ N + +
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q K+ A + D + + E + + + + +L S+E + LQ
Sbjct: 1637 IKQ---LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI-------QLQ 1686
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
E+L + E + QQ + + A + ++ E K LEA +L+EE +
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEAL--EQLHSQLIIKEQEMKAKLEQIEESASEK 357
++ + LK K N I+ + + E+ A E QL + +E+K KL+++E + K
Sbjct: 1746 ELINDRLK-KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
K E + ++E + K Q ++++ + L Q D ++ K+
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRD 476
D+ ST +K LK +L E E E + N + K +E ++ ET+ ++ R+
Sbjct: 1865 ADKAST-------RLKQLKRQLEEA----EEEAQRANASRRKLQRELEDATETADAMNRE 1913
Query: 477 IVHVLTLRLRESD 489
V L +LR D
Sbjct: 1914 -VSSLKNKLRRGD 1925
Score = 57.6 bits (133), Expect = 1e-07
Identities = 84/425 (19%), Positives = 181/425 (42%), Gaps = 30/425 (7%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNA- 180
+ K + + + L++ ++E+ T+ + + + E D KL +L +N +
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKL-RLEVNLQAMKAQFERD 1572
Query: 181 VQGTDA---EKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLEEVITVRDSL 234
+QG D EK ++ +R ELE + + V + +M+L LE I +
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKG-HHALALEANESIRREYKIELEALKTKLDEEKQ 293
+ ++L + + + + L+ + + +A E+ ++ +E E ++ + +E
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAA 1691
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
A +K + QE + + S K + E+ LE +QL + +E + E I
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI--- 1748
Query: 354 ASEKLKICEIQFEERSQSI---QEHCSQQEKTIQYLEQEIKELKYTL-DLTNNQNSDLKQ 409
+++LK +Q ++ + + + H + E Q LE++ KELK L ++ S K
Sbjct: 1749 -NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
+ L+ +L + N +E + + + +T E + + L V+ + ++
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQ-VRRT---EKKLKDVLLQVDDERRNAEQY-- 1861
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
+D + RL++ +LE+ E++ Q +++ L+ EL T + RE
Sbjct: 1862 -----KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 530 YKEAL 534
K L
Sbjct: 1917 LKNKL 1921
Score = 57.2 bits (132), Expect = 2e-07
Identities = 131/694 (18%), Positives = 289/694 (41%), Gaps = 70/694 (10%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K KA K+TL + ++ + +++ + +K + + ++++ NE +++
Sbjct: 1209 KRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR 1268
Query: 139 EILKELATKFRQSHNNID--FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDM 196
L + TK + +N+ ++ D K SKL + + ++ Q E+ ++ +
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS-L 1327
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ-R 255
+++ ++E + + ++ +++ +LE+ I + D+++K+ + L ++ +
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 256 LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE---NLKTKHNA 312
++ K L+ E + K LE KT+L +E ++ ++ NL+ K
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDK--LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK--LEQIEESASEKLKICEIQFEERSQ 370
+ L + A E+ ++ +E+E KA +EE+ +K ++ + + R++
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 371 ---------SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ---NSDLKQELN-NLKNC 417
+ + + EK+ + LEQ+++E+K L+ ++ D K L NL+
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 418 KDELSTEKFNFIEEIKTLKDELI----EKTINYENEKNKLNLAV------EKAIKEKNKF 467
K + + E+ + K +L+ E E+E+ + ++AV E +K+
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 468 ETSLSVTRD--IVHVLTLRLRESDSELEQLED----QVQMLTSAKE-------------V 508
S + RD I + L+ + D + +L+D + ++L AKE
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDC-MRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQ---- 563
L+ EL + +E DE + + N K AL E R +E + L E L+
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 564 NVE------KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
N E K+A ++ I +L + +K N++ + R+ E K L EM
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENE----RYXXXXXXXXSLVVELSLLRQENEELTM 673
+AQ L E + + +++++ R+ E+
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 674 TVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
K S+ + +LK+ LE+++ + + R+ L+
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
>M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle
myosin heavy chain (NMHC) mRNA, 3' end. ).
Length = 1247
Score = 75.4 bits (177), Expect = 7e-13
Identities = 111/515 (21%), Positives = 237/515 (46%), Gaps = 58/515 (11%)
Query: 88 IKKTLTCPKNKILPQDELV-QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT 146
++K T K K L +++++ + Q+ ++ K++ + E +I ++ + + +E K LA
Sbjct: 250 LEKVTTEAKLKKLEEEQIILEDQNCKLA-KEKKLLE--DRIAEFTTNLTEEEEKSKSLA- 305
Query: 147 KFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK 206
K + H + +++ +L + ++G D+ +S I +++++I EL+ +
Sbjct: 306 KLKNKHEAM-ITDLEERLRREEKQRQELEKTRRKLEG-DSTDLSDQIAELQAQIAELKMQ 363
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA 266
+ E+ Q L+ +EE ++ K ++E E ++E Q+ LE + A
Sbjct: 364 LAKKEEEL---QAALARVEEEAAQKNMALKKIREL----ESQISELQEDLESERASRNKA 416
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
E +R+ ELEALKT+L++ + + Q+ L++K + LK + L+E+
Sbjct: 417 ----EKQKRDLGEELEALKTELEDTLDSTAA-----QQELRSKREQEVNILK-KTLEEEA 466
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
+ E +Q+ QEM+ K Q E +E+L E+++ ++ + EK Q L
Sbjct: 467 KTHE---AQI----QEMRQKHSQAVEELAEQL--------EQTKRVK---ANLEKAKQTL 508
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-LKDELIEKTIN 445
E E EL + + D + + ++ EL KFN E ++T L D++ + +
Sbjct: 509 ENERGELANEVKVLLQGGRDSEHKRKKVEAQLQELQV-KFNEGERVRTELADKVTKLQVE 567
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+N L+ + K+ K +T+D L +L+++ L++ Q L++
Sbjct: 568 LDNVTGLLSQSDSKSSK----------LTKDF-SALESQLQDTQELLQEENRQKLSLSTK 616
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
+ +E+E +++ L E E + L ++ A K+ ME +V +E+ + V
Sbjct: 617 LKQVEDEKNSFREQLEEEEEEAKHNLEKQIATLHAQVADMKKK---MEDSVGCLETAEEV 673
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLRE 600
+++ ++L + E V K ++ + +E
Sbjct: 674 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 708
Score = 67.7 bits (158), Expect = 1e-10
Identities = 104/532 (19%), Positives = 229/532 (43%), Gaps = 27/532 (5%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA 145
++K L + Q EL ++ E+ +T+ E K E E+ Q + ++ELA
Sbjct: 429 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 488
Query: 146 TKFRQSHN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE----KVSAMINDMRSRI 200
+ Q+ + + + L R N + G D+E KV A + +++ +
Sbjct: 489 EQLEQTKRVKANLEKAKQTLENERGELAN-EVKVLLQGGRDSEHKRKKVEAQLQELQVKF 547
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
E E+ L ++V Q+EL ++ +++ DS L + ++ E L +TQ+ L+ +
Sbjct: 548 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE-E 606
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
L+L ++ + E + + +L+EE++ +K ++++ + T H A + +K +
Sbjct: 607 NRQKLSLSTK---LKQVEDEKNSFREQLEEEEEE--AKHNLEKQ-IATLH-AQVADMKKK 659
Query: 321 MLKEK-C-EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQ 378
M C E E++ +L K+ E ++ + + +A +KL+ + + ++ +
Sbjct: 660 MEDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH 718
Query: 379 QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE 438
Q ++ LE++ K+ L ++ +E + + E T+ + + +E
Sbjct: 719 QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL----EE 774
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
+E+ E + +E + K+ S+ L ++ E ++LE+LED+
Sbjct: 775 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 834
Query: 499 VQMLTSAKEVLENEL----TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+Q AK LE L ++ L + +E K+ LV ++ A ++ +
Sbjct: 835 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 894
Query: 555 NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
V + L+ K+ + + E ++ L+K +Q+K E++ R
Sbjct: 895 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTR 945
Score = 65.7 bits (153), Expect = 5e-10
Identities = 70/317 (22%), Positives = 143/317 (45%), Gaps = 17/317 (5%)
Query: 300 KVDQENLKTKHNA-SIESLKNQMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESASE 356
KV ++ L ++ +E+L++Q++ EK + EQL ++ L + +E++A+L ++ E
Sbjct: 142 KVREKQLAAENRLMEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 201
Query: 357 KLKICEIQFEE---RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
E + EE R Q +Q + ++ IQ LE++++E + + + +L
Sbjct: 202 ICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 261
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L+ + L + +E K L+D + E T N E+ K + K KNK E ++
Sbjct: 262 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK----SKSLAKLKNKHEAMITD 317
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ + + +E + +LE L+ L+ ++ K L ++ +E + A
Sbjct: 318 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQAA 374
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKES 591
L + + A +I E + E +++E E + + K +L E++E LK E
Sbjct: 375 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 434
Query: 592 NSQI--KFLREEVEKKR 606
+ ++E+ KR
Sbjct: 435 EDTLDSTAAQQELRSKR 451
Score = 62.5 bits (145), Expect = 5e-09
Identities = 104/462 (22%), Positives = 193/462 (41%), Gaps = 45/462 (9%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV-ITVRDSLCKDLQEK-- 241
+ +K+ I ++ ++ E E + L E + +L LEE I + D CK +EK
Sbjct: 223 EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 282
Query: 242 -------LTSNELTLAETQQRLEMVKG-HHALALEANESIRREYKI--ELEALKTKLD-- 289
T+N E + L +K H A+ + E +RRE K ELE + KL+
Sbjct: 283 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 342
Query: 290 --------EEKQAIISKCKVDQENLKTKHNASI-----ESLKNQMLKEKCEALEQLHSQL 336
E QA I++ K+ + + A++ E+ + M +K LE S+L
Sbjct: 343 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 402
Query: 337 ---IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
+ E+ + K E+ + E+L+ + + E+ ++ +QQE + EQE+ L
Sbjct: 403 QEDLESERASRNKAEKQKRDLGEELEALKTELED---TLDSTAAQQELRSKR-EQEVNIL 458
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
K TL+ + QE+ + E E+ +E+ K +K L + ENE+ +L
Sbjct: 459 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ---LEQTKRVKANLEKAKQTLENERGEL 515
Query: 454 NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE-----V 508
V+ ++ E + L ++ E + +L D+V L + +
Sbjct: 516 ANEVKVLLQGGRDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLL 575
Query: 509 LENELTTYKNTLNNTVRECD--EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
+++ + K T + + E + +E L + K +L+ + ++ + + E L+ E
Sbjct: 576 SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 635
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+EA L L V +KK+ + L E KR L
Sbjct: 636 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 677
Score = 59.3 bits (137), Expect = 5e-08
Identities = 83/373 (22%), Positives = 161/373 (43%), Gaps = 31/373 (8%)
Query: 124 NKQIEDYKNEIA-QLQEILKELATKFRQSHNNIDFN---EIDRKLSKLRINNTNCHTEHN 179
++Q E+ K ++ Q++E+ EL + +Q + E+D K + I++ N + +
Sbjct: 864 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 923
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q K+ A + D + + E + + + + +L S+E + LQ
Sbjct: 924 IKQ---LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI-------QLQ 973
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
E+L + E + QQ + + A + ++ E K LEA +L+EE +
Sbjct: 974 EELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNT 1032
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEAL--EQLHSQLIIKEQEMKAKLEQIEESASEK 357
++ + LK K N I+ + + E+ A E QL + +E+K KL+++E + K
Sbjct: 1033 ELINDRLK-KANLQIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1091
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
K E + ++E + K Q ++++ + L Q D ++ K+
Sbjct: 1092 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1151
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRD 476
D+ ST +K LK +L E E E + N + K +E ++ ET+ ++ R+
Sbjct: 1152 ADKAST-------RLKQLKRQLEEA----EEEAQRANASRRKLQRELEDATETADAMNRE 1200
Query: 477 IVHVLTLRLRESD 489
V L +LR D
Sbjct: 1201 -VSSLKNKLRRGD 1212
Score = 56.8 bits (131), Expect = 3e-07
Identities = 84/425 (19%), Positives = 181/425 (42%), Gaps = 30/425 (7%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNA- 180
+ K + + + L++ ++E+ T+ + + + E D KL +L +N +
Sbjct: 802 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKL-RLEVNLQAMKAQFERD 859
Query: 181 VQGTDA---EKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLEEVITVRDSL 234
+QG D EK ++ +R ELE + + V + +M+L LE I +
Sbjct: 860 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 919
Query: 235 CKDLQEKLTSNELTLAETQQRLEMVKG-HHALALEANESIRREYKIELEALKTKLDEEKQ 293
+ ++L + + + + L+ + + +A E+ ++ +E E ++ + +E
Sbjct: 920 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAA 978
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
A +K + QE + + S K + E+ LE +QL + +E + E I
Sbjct: 979 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI--- 1035
Query: 354 ASEKLKICEIQFEERSQSI---QEHCSQQEKTIQYLEQEIKELKYTL-DLTNNQNSDLKQ 409
+++LK +Q ++ + + + H + E Q LE++ KELK L ++ S K
Sbjct: 1036 -NDRLKKANLQIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1094
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
+ L+ +L + N +E + + + +T E + + L V+ + ++
Sbjct: 1095 SITALEAKIAQLEEQLDNETKERQAACKQ-VRRT---EKKLKDVLLQVDDERRNAEQY-- 1148
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
+D + RL++ +LE+ E++ Q +++ L+ EL T + RE
Sbjct: 1149 -----KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1203
Query: 530 YKEAL 534
K L
Sbjct: 1204 LKNKL 1208
Score = 55.6 bits (128), Expect = 6e-07
Identities = 131/645 (20%), Positives = 266/645 (41%), Gaps = 64/645 (9%)
Query: 85 NSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIA-QLQEILKE 143
+S + K + ++++ EL+Q ++ R K ++ KQ+ED KN QL+E +E
Sbjct: 582 SSKLTKDFSALESQLQDTQELLQEEN---RQK-LSLSTKLKQVEDEKNSFREQLEEEEEE 637
Query: 144 LATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT---DAEKVSAMINDMRSRI 200
+ + D K K ++ C V+ D E +S + +
Sbjct: 638 AKHNLEKQIATLHAQVADMK--KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 695
Query: 201 IELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+LEK L E+ D ++L R S C +L++K + LAE + +
Sbjct: 696 DKLEKTKTRLQQELDDLLVDLDHQ------RQSAC-NLEKKQKKFDQLLAEEKT----IS 744
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
+A + E+ RE + + +L L+E + K + E L + +E L +
Sbjct: 745 AKYAEERDRAEAEAREKETKALSLARALEEAMEQ-----KAELERLNKQFRTEMEDLMSS 799
Query: 321 M--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQ 378
+ + LE+ L + +EMK +LE++E+ + + +++ E Q+++ +Q
Sbjct: 800 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL-QATEDAKLRLEVNLQAMK---AQ 855
Query: 379 QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE 438
E+ +Q +++ +E K L Q +++ EL + + + + ++K L
Sbjct: 856 FERDLQGRDEQSEEKKKQLV---RQVREMEAELEDERKQRSMAVAARKKLEMDLKDL--- 909
Query: 439 LIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS-VTRDIVHVLTLRLRESDSELEQLED 497
E I+ N KN+ ++AIK+ K + + R++ R E ++ ++ E
Sbjct: 910 --EAHIDSAN-KNR-----DEAIKQLRKLQAQMKDCMRELDDTRASR-EEILAQAKENEK 960
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+++ + + L+ EL + +E DE + + N K AL E R +E +
Sbjct: 961 KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIA 1019
Query: 558 -LIESLQ----NVE------KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
L E L+ N E K+A ++ I +L + +K N++ + R+ E K
Sbjct: 1020 QLEEELEEEQGNTELINDRLKKANLQIDQINADLNLERGHAQKNENARQQLERQNKELKV 1079
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE----RYXXXXXXXXSLVVELS 662
L EM +AQ L E + + +++++
Sbjct: 1080 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1139
Query: 663 LLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLK 707
R+ E+ K S+ + +LK+ LE+++ + + R+ L+
Sbjct: 1140 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1184
>BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 74.9 bits (176), Expect = 9e-13
Identities = 77/392 (19%), Positives = 182/392 (46%), Gaps = 20/392 (5%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM 192
E+ Q ++ L++L + + + E R+L+ L+ + H+ E+ A
Sbjct: 731 ELLQAKQDLQDLLIAKEEQEDLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +R + E K E L + + + + E + + + LQ + E +A+
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q+++E +KG A A E + E + EAL EEK+A+ ++ ++ E + N
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 313 SIESLKNQMLKEKC-------EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
S + + + L EK E L +L +++ + + +E++++ ++ ++
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQNSD----LKQELNNLKNCK 418
E + E+ + + + +++++KE + LT + D +++EL + + +
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
DE T++ + +K L+ EL K+ + ++++++L +E + ++ E L R+
Sbjct: 1029 DEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQMEDKV---SQLEMELEEERNNS 1084
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+L+ R+ S ++EQL +++ +A++ LE
Sbjct: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Score = 59.7 bits (138), Expect = 4e-08
Identities = 110/514 (21%), Positives = 214/514 (41%), Gaps = 38/514 (7%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET---QQRLEMVKGHHALALEANESI- 273
Q+E+ + + + R+ + +L+E + + + E QQRLE +G LE +
Sbjct: 631 QLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 274 --RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL--KNQMLKEKCEAL 329
R +++ E+ L+ +L E + S K ++ K A IE L Q L++ A
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDS-AKRSEDREK---GALIEELLQAKQDLQDLLIAK 746
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
E+ L +E+E+ A ++E S +++ + Q++ Q+++E + K ++ L
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK-DELIEKTI- 444
+ T + L++E L+ +EL +I+ LK DE K
Sbjct: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866
Query: 445 -NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
YE E +L A+ A KE+ + ++ + + L ++ E +QL ++++ +
Sbjct: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
KE +L KN + N + + ++ K+ L KE I+E + T LQ
Sbjct: 927 EQKE----QLRRLKNEMEN-----ERW-----HLGKTIEKLQKEMADIVEASRTSTLELQ 972
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXX 621
N + + Y+E + EL E LK+++ + + +++ + L E
Sbjct: 973 N-QLDEYKEKN--RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 622 XXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
R LL Q DL LE ++ + ++S L E EE S
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
I + ++ +EQ + R+ L+ K +++
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
Score = 57.2 bits (132), Expect = 2e-07
Identities = 85/401 (21%), Positives = 168/401 (41%), Gaps = 21/401 (5%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNE-LTLAETQQRLEMVKGHHALALEANESIRRE 276
Q EL+ T + L L+E T N+ T + E ++ + A + + +
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E +K L+++ + I ++ ++ L+ K+ +I+ + +M + E L H++
Sbjct: 603 CNSTSE-VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM-RANLEELRSQHNE 660
Query: 336 LIIKEQEMKAKLEQIEESASEKL-KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+ + ++ +LE+ E + L ++ +++ ER Q E Q++ + + E+ K
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKM-EREQHQTEIRDLQDQ-LSEMHDELDSAK 718
Query: 395 YTLDLTN----NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+ D + KQ+L +L K+E E+ LK L E+ +++ E
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+KL E+ E S+ V VL R S+ + E +V++L E L+
Sbjct: 779 DKLK---EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+ + R+ ++ K + K+K L K I + L+ + + EKEA
Sbjct: 836 GRSEELERRVAQLQRQIEDLKG---DEAKAKETLKKYEGEIRQLEEALVHA-RKEEKEAV 891
Query: 571 RELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
++NEL L + + Q + L+EE E+K L
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL 932
Score = 50.4 bits (115), Expect = 2e-05
Identities = 81/397 (20%), Positives = 160/397 (40%), Gaps = 28/397 (7%)
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFE 366
TK ++ K Q LK + Q ++Q E+K LEQ + E ++ ++Q E
Sbjct: 574 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLE 633
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKE-------LKYTLDLTNNQNSDLKQELNNLKNCK 418
+ Q+I+E + ++ L + E L+ L+ + + +EL +K +
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
++ TE + +++ + DEL + + EK L +E+ ++ K + L +
Sbjct: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL---IEELLQAKQDLQDLLIAKEEQE 750
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV--- 535
+L R RE + L+++V + L+ + L +V E + E L
Sbjct: 751 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
N + A T+ ++++ E LQ +E R + ++ + IED++ + ++ +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEE---NEKLQGRSEELERRVAQLQRQ-IEDLKGDEAKAKETL 866
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL---LAQAAADLSRLENENERYXXXXX 652
K E+ R L E R L L A +LS+ E ++
Sbjct: 867 KKYEGEI---RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
+L L+ E E + K I+KL+K++
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGK---TIEKLQKEM 957
Score = 48.0 bits (109), Expect = 1e-04
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 30/358 (8%)
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ------EIKELKYTLDLTNNQNSDLKQ 409
EK++ + + +Q + C+ + LEQ E+ EL+ L L ++K+
Sbjct: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
E ++ +EL ++ +EE TL+ L E + +L +E+ + K + E
Sbjct: 643 ERERMRANLEELRSQHNEKVEENSTLQQRL-------EESEGELRKNLEELFQVKMEREQ 695
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKEVLENELTTYKNTLNNTV 524
+ RD+ L+ E DS ++ ED+ ++ L AK+ L+ +L K + +
Sbjct: 696 HQTEIRDLQDQLSEMHDELDS-AKRSEDREKGALIEELLQAKQDLQ-DLLIAKEEQEDLL 753
Query: 525 RECDEYKEALVNILKSK-AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
R+ + AL LK + ++ +E ++ E +++L+ +EA + + + +
Sbjct: 754 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR-SNT 812
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E + + ++K L+EE EK + E + A+A L + E E
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 644 NERYXXXXXXXXSLVVELSLLRQ--ENE------ELTMTVAKQSSIIDKLKKDLEQSQ 693
+ E R+ ENE L+ T +Q + +KLK++ EQ +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Score = 45.6 bits (103), Expect = 6e-04
Identities = 60/312 (19%), Positives = 132/312 (42%), Gaps = 29/312 (9%)
Query: 125 KQIEDYKNEIAQLQEILK----ELATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEH 178
K IE + E+A + E + EL + + N + E+ R+L + +
Sbjct: 948 KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 1007
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+Q + + + D + E K + L+ + D + EL + + R L K +
Sbjct: 1008 MKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM 1066
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY------KIELEALKTKLDEEK 292
++K++ E+ L E + +++ + + E E +R E + +LE K L+ +
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
Query: 293 QAIISKC-------KVDQENLKTKHNASIESLKNQMLKEKCEA---------LEQLHSQL 336
+ + S+ + +E L + A I L++++ E+ + LE+ +L
Sbjct: 1127 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL 1186
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
+++ + L ++ S +LK + Q EE + I S ++K + LE+++ ++
Sbjct: 1187 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 1246
Query: 397 LDLTNNQNSDLK 408
N+ DL+
Sbjct: 1247 QGQLNSMKKDLR 1258
Score = 44.0 bits (99), Expect = 0.002
Identities = 55/285 (19%), Positives = 140/285 (49%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL-LEQT 1041
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER----NNSDLLSERI-SRSRE 1096
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E L+N++L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 1097 QMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 1156
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 1260
>BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 74.9 bits (176), Expect = 9e-13
Identities = 112/477 (23%), Positives = 224/477 (46%), Gaps = 46/477 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KN+IL ++ L Q+ +I+ + ++ E+ ++ + ++Q+ E+ +R+ I
Sbjct: 903 KNEILKRN-LENTQN-QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
Query: 156 DFNEIDRKLSKLRINNTN-CHTEHNA--VQGTDAE-KVSAMINDMRSRIIELEKKCEALD 211
+ K K ++ C A V + E K A +++ ++ E +K +
Sbjct: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLT----SNELTLAETQQRLEMVKGHHALAL 267
EV + E L++ I +L KDL++K S+E+ A +++ E+ K L+
Sbjct: 1021 EEVKKNKQENDKLKKEIF---TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 268 EANESIR-REYKIELEALKTKLDEEKQAIISKCKVDQEN---LKTKHNASIESLKNQMLK 323
+ E +E +E A +T Q ++ K V E LK N +IE+LK ++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKS 1137
Query: 324 -EKCEALEQ-----LHSQLIIKEQEMKAKLE---QIEESASEKLKICEIQF---EERSQS 371
++C EQ LH QL+ ++ L QI+E+ +++ I + EE SQ+
Sbjct: 1138 MQRCYEKEQQTVTKLH-QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQN 1196
Query: 372 IQEHCSQQEKTIQYLEQEIKEL--KYTLDLTNNQ--NSDLKQELNNLKNCKDELSTEKFN 427
E S+ + +Q +Q +K+L + +DL+ + SDL+ ++++L L+ +
Sbjct: 1197 KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1256
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLR 486
EE+ K +K I+ ++EK L+ ++E+ IK +K + + SL+ + L R++
Sbjct: 1257 VCEEVLHAK----KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITE----LQRRIQ 1308
Query: 487 ESDSELEQLEDQVQMLTSAKEVLE---NELTTYKNTLNNTVRECDEYKEALVNILKS 540
ES ++E ++++ L + E L+ N L+ T N + + + L + +KS
Sbjct: 1309 ESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKS 1365
Score = 69.3 bits (162), Expect = 4e-11
Identities = 114/539 (21%), Positives = 232/539 (43%), Gaps = 34/539 (6%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEIL 141
+A S K L+ P K + + + E+ K + + E ++ E +EI QL+ L
Sbjct: 615 QAKELSAKLALSIPAEKF---ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
Query: 142 KELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ + K Q + ++ +L + TE T +++ + D +
Sbjct: 672 ENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL--- 728
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
L+++ L E+ + + L E++ D++ DL KL ++T T+++LEM K
Sbjct: 729 -LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLL--DVTQKYTEKKLEMEK- 784
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIIS------KCKVDQENLKTKHNASIE 315
L LE N+S+ ++ LE + ++ ++ II+ + K LK K E
Sbjct: 785 ---LLLE-NDSLSKDVS-RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
Query: 316 SLKNQMLKEKCEALEQLHSQLI-IK-EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+ + + E + + +Q + +K +E+K L + +L + +FE+ +Q
Sbjct: 840 KI-HALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898
Query: 374 EHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
+ + E + ++ + +IK +L + S L Q + +++ E+ E
Sbjct: 899 KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958
Query: 431 EIKTLKDELI--EKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRE 487
EI TL E+ +K ++ E K+ A + +E + KF+ + +D + T +
Sbjct: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTK 546
S+ E+++ + + L L+ +L K L E + + L K L++
Sbjct: 1019 SEEEVKKNKQENDKLKKEIFTLQKDLRD-KTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 547 EHTRIMEHNVTLIE--SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++T + L+E + Q E A + L ++ +E VE LKK N I+ L+EE++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK 1136
Score = 65.7 bits (153), Expect = 5e-10
Identities = 94/436 (21%), Positives = 184/436 (42%), Gaps = 28/436 (6%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHTEHNA 180
++ K+I K+ I +L++ L EL K + I + L K+ N H
Sbjct: 808 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE 867
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
V+ T ++ + +++++KK E ++ E +++ E++ + +L ++ Q
Sbjct: 868 VKMT----LNDTLAKTNRELLDVKKKFEDINQEF----VKIKDKNEIL--KRNL-ENTQN 916
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCK 300
++ + ++LAE + ++ + ++N I Y+ E + T L E +A +
Sbjct: 917 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVT-LHAEIKAQKKELD 975
Query: 301 VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
QE +K K+ A I S + K K E L QL + Q+ E+++++ E K+
Sbjct: 976 TIQECIKVKY-APIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
+ F ++Q+ + I+ + + L D N Q DL Q+ +KN K++
Sbjct: 1034 KKEIF-----TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE---KNKLNLAVEKAIKEKNKFETSLSVTRDI 477
L E EI +++ L ++ + E K LN +E +E + +
Sbjct: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
V L L + L + +Q+ KE E E+ K +L E E V+
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQI----KEAFEKEVGIIKASLREKEEESQNKMEE-VSK 1203
Query: 538 LKSKAALTKEHTRIME 553
L+S+ TK+ + +E
Sbjct: 1204 LQSEVQNTKQALKKLE 1219
Score = 63.3 bits (147), Expect = 3e-09
Identities = 87/438 (19%), Positives = 208/438 (47%), Gaps = 38/438 (8%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE-KLTSNELTLAE 251
I +++ ++ EL+KKC +++ E ++L+++++ + K +E K+T N+ TLA+
Sbjct: 820 IVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND-TLAK 878
Query: 252 TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD------QEN 305
T + L VK + I+ + +I L+ ++ K IS + + ++
Sbjct: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLE--QIEESASEKLKICEI 363
++ +++ E L N ++ E + LH+++ +++E+ E +++ + + CE
Sbjct: 939 MRKVQDSNAEILANY--RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER 996
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-L 421
+F+ + +++ S+Q + E+E+K+ K +N LK+E+ L K+ +D+ +
Sbjct: 997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNK-------QENDKLKKEIFTLQKDLRDKTV 1049
Query: 422 STEKFNFIEEIKTLK-DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + +E + K DEL ++ + + ++ EK ++E K + + ++++
Sbjct: 1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Query: 481 LTLRLRESDS-------ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNT------VREC 527
+ L + ++ +E L+++++ + E + +T L N + E
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
Query: 528 DEYKEAL---VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
+ KEA V I+K+ +E ++ V+ ++S K+A ++L T + +
Sbjct: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
Query: 585 ELLKKESNSQIKFLREEV 602
+ K + +QI L E++
Sbjct: 1230 KATKSDLETQISSLNEKL 1247
Score = 55.2 bits (127), Expect = 8e-07
Identities = 93/474 (19%), Positives = 200/474 (42%), Gaps = 23/474 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L Q L QD E+ K ++ I+D + E L+E L+++ + R + +
Sbjct: 268 KGPSLQQRNLTHMQD-EVNVKSHQ--REHQNIQDLEIENEDLKERLRKIQQEQRILLDKV 324
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
N + +L++ + + +E ++ A K +R+ I L+ + + +++
Sbjct: 325 --NGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT-IEALKNRFKYFESDHL 381
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
S+ +E + ++ + TS + A Q R + +L + + S
Sbjct: 382 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIP-AHMQSRSMLRPLELSLPSQTSYSENE 440
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL-EQLHS 334
K ELEA++T + KQ + LK ++ + + + + L +CE + E
Sbjct: 441 ILKKELEAMRTFCESAKQ----------DRLKLQNELAHKVAECKALALECERVKEDSDE 490
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI-QEHCSQQEKTIQYLEQEIKEL 393
Q+ E +K +++ ES K+K + F + + E S + + L+ ++K+L
Sbjct: 491 QIKQLEDALKDVQKRMYESEG-KVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL 549
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
K + + + L+ ++ + +E ++ IEE K L+ EL + E + K+
Sbjct: 550 KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 609
Query: 454 NLAVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+A + K S+ + ++ L+ + E +L ++E + + S L+
Sbjct: 610 TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
EL K L V+ +E+++ + + L K+ T + N TL + ++ V
Sbjct: 670 ELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Score = 54.4 bits (125), Expect = 1e-06
Identities = 69/345 (20%), Positives = 150/345 (43%), Gaps = 30/345 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K K N +KK + + + + L++ R + E NKQ++D + +++
Sbjct: 1024 KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK 1083
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ ++L + + + + L K + ++ GT E + + M+
Sbjct: 1084 NVKEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-IENLKEELKSMQ- 1139
Query: 199 RIIELEKKCEALDNEVYDKQMELS-SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
R E E++ +++ + Q S L E + ++++ K++ S E+Q ++E
Sbjct: 1140 RCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
V ++ E + +ALK KL+ + +SK K + +L+T+ ++ E L
Sbjct: 1200 EV-----------SKLQSEVQNTKQALK-KLETREVVDLSKYKATKSDLETQISSLNEKL 1247
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
N L K E + E+ + AK ++I SA ++ ++ E+ + +E C
Sbjct: 1248 AN--LNRKYEE---------VCEEVLHAKKKEI--SAKDEKELLHFSIEQEIKDQKERCD 1294
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
+ TI L++ I+E ++ +N+ ++L ++ LK + LS
Sbjct: 1295 KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1339
Score = 54.0 bits (124), Expect = 2e-06
Identities = 137/625 (21%), Positives = 254/625 (40%), Gaps = 58/625 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E Q++D K + + +L + +Q N + E R KL N E +
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQ--NEMIVEEFKRDEGKLIEENKRLQKELSMC 598
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK 241
+ + EK + +M + EL K AL + SSL + + K L E
Sbjct: 599 E-MEREKKGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEK---AKKLVEM 653
Query: 242 LTSNELTLAETQQ---RLEMVKGHHALAL--EANESI--RREYKI-ELEALKTKLDEEKQ 293
+E +L+E +Q LE VK A + E +E + R E K EL T+L + Q
Sbjct: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 294 AI---ISKCKVDQENLKTK-HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
+ I K +D + LK + HN +IE + + + E +++ H +I ++ KL
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAII---DDLNRKLLD 770
Query: 350 IEESASEK-LKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTLDLTNNQNS 405
+ + +EK L++ ++ E + S+ + S+ E + E+EI LK + Q S
Sbjct: 771 VTQKYTEKKLEMEKLLLE--NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLS 828
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-- 463
+LK++ + L++E N +K + +E K LN + K +E
Sbjct: 829 ELKKKCGEDQEKIHALTSENTN----LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELL 884
Query: 464 --KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
K KFE + ++ V ++++ + L++ + Q A+ + E ++L+
Sbjct: 885 DVKKKFE---DINQEFV-----KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 936
Query: 522 NTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
++R+ D E L N K + + H I L +++Q K Y + + + E
Sbjct: 937 QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL-DTIQECIKVKYAPIVSFE-EC 994
Query: 581 IEDVELLKKESNSQIK-------FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQA 633
+ +KE Q+ EEV+K + + VL+ ++
Sbjct: 995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1054
Query: 634 ---AADLSRLENE-NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
LSR +E N++ + L +EN + T + +++ K L
Sbjct: 1055 HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1114
Query: 690 EQSQYTPKSPSVLRKSLKVGKENMQ 714
EQ + KS + ++LK ++MQ
Sbjct: 1115 EQVEALKKSLNGTIENLKEELKSMQ 1139
>BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 74.9 bits (176), Expect = 9e-13
Identities = 112/477 (23%), Positives = 224/477 (46%), Gaps = 46/477 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KN+IL ++ L Q+ +I+ + ++ E+ ++ + ++Q+ E+ +R+ I
Sbjct: 903 KNEILKRN-LENTQN-QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
Query: 156 DFNEIDRKLSKLRINNTN-CHTEHNA--VQGTDAE-KVSAMINDMRSRIIELEKKCEALD 211
+ K K ++ C A V + E K A +++ ++ E +K +
Sbjct: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLT----SNELTLAETQQRLEMVKGHHALAL 267
EV + E L++ I +L KDL++K S+E+ A +++ E+ K L+
Sbjct: 1021 EEVKKNKQENDKLKKEIF---TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 268 EANESIR-REYKIELEALKTKLDEEKQAIISKCKVDQEN---LKTKHNASIESLKNQMLK 323
+ E +E +E A +T Q ++ K V E LK N +IE+LK ++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKS 1137
Query: 324 -EKCEALEQ-----LHSQLIIKEQEMKAKLE---QIEESASEKLKICEIQF---EERSQS 371
++C EQ LH QL+ ++ L QI+E+ +++ I + EE SQ+
Sbjct: 1138 MQRCYEKEQQTVTKLH-QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQN 1196
Query: 372 IQEHCSQQEKTIQYLEQEIKEL--KYTLDLTNNQ--NSDLKQELNNLKNCKDELSTEKFN 427
E S+ + +Q +Q +K+L + +DL+ + SDL+ ++++L L+ +
Sbjct: 1197 KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1256
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLR 486
EE+ K +K I+ ++EK L+ ++E+ IK +K + + SL+ + L R++
Sbjct: 1257 VCEEVLHAK----KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITE----LQRRIQ 1308
Query: 487 ESDSELEQLEDQVQMLTSAKEVLE---NELTTYKNTLNNTVRECDEYKEALVNILKS 540
ES ++E ++++ L + E L+ N L+ T N + + + L + +KS
Sbjct: 1309 ESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKS 1365
Score = 69.3 bits (162), Expect = 4e-11
Identities = 114/539 (21%), Positives = 232/539 (43%), Gaps = 34/539 (6%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEIL 141
+A S K L+ P K + + + E+ K + + E ++ E +EI QL+ L
Sbjct: 615 QAKELSAKLALSIPAEKF---ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
Query: 142 KELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ + K Q + ++ +L + TE T +++ + D +
Sbjct: 672 ENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL--- 728
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
L+++ L E+ + + L E++ D++ DL KL ++T T+++LEM K
Sbjct: 729 -LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLL--DVTQKYTEKKLEMEK- 784
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIIS------KCKVDQENLKTKHNASIE 315
L LE N+S+ ++ LE + ++ ++ II+ + K LK K E
Sbjct: 785 ---LLLE-NDSLSKDVS-RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
Query: 316 SLKNQMLKEKCEALEQLHSQLI-IK-EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+ + + E + + +Q + +K +E+K L + +L + +FE+ +Q
Sbjct: 840 KI-HALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898
Query: 374 EHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
+ + E + ++ + +IK +L + S L Q + +++ E+ E
Sbjct: 899 KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958
Query: 431 EIKTLKDELI--EKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRE 487
EI TL E+ +K ++ E K+ A + +E + KF+ + +D + T +
Sbjct: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTK 546
S+ E+++ + + L L+ +L K L E + + L K L++
Sbjct: 1019 SEEEVKKNKQENDKLKKEIFTLQKDLRD-KTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 547 EHTRIMEHNVTLIE--SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++T + L+E + Q E A + L ++ +E VE LKK N I+ L+EE++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK 1136
Score = 65.7 bits (153), Expect = 5e-10
Identities = 94/436 (21%), Positives = 184/436 (42%), Gaps = 28/436 (6%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHTEHNA 180
++ K+I K+ I +L++ L EL K + I + L K+ N H
Sbjct: 808 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE 867
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
V+ T ++ + +++++KK E ++ E +++ E++ + +L ++ Q
Sbjct: 868 VKMT----LNDTLAKTNRELLDVKKKFEDINQEF----VKIKDKNEIL--KRNL-ENTQN 916
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCK 300
++ + ++LAE + ++ + ++N I Y+ E + T L E +A +
Sbjct: 917 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVT-LHAEIKAQKKELD 975
Query: 301 VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
QE +K K+ A I S + K K E L QL + Q+ E+++++ E K+
Sbjct: 976 TIQECIKVKY-APIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
+ F ++Q+ + I+ + + L D N Q DL Q+ +KN K++
Sbjct: 1034 KKEIF-----TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE---KNKLNLAVEKAIKEKNKFETSLSVTRDI 477
L E EI +++ L ++ + E K LN +E +E + +
Sbjct: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
V L L + L + +Q+ KE E E+ K +L E E V+
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQI----KEAFEKEVGIIKASLREKEEESQNKMEE-VSK 1203
Query: 538 LKSKAALTKEHTRIME 553
L+S+ TK+ + +E
Sbjct: 1204 LQSEVQNTKQALKKLE 1219
Score = 63.3 bits (147), Expect = 3e-09
Identities = 87/438 (19%), Positives = 208/438 (47%), Gaps = 38/438 (8%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE-KLTSNELTLAE 251
I +++ ++ EL+KKC +++ E ++L+++++ + K +E K+T N+ TLA+
Sbjct: 820 IVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND-TLAK 878
Query: 252 TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD------QEN 305
T + L VK + I+ + +I L+ ++ K IS + + ++
Sbjct: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLE--QIEESASEKLKICEI 363
++ +++ E L N ++ E + LH+++ +++E+ E +++ + + CE
Sbjct: 939 MRKVQDSNAEILANY--RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER 996
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-L 421
+F+ + +++ S+Q + E+E+K+ K +N LK+E+ L K+ +D+ +
Sbjct: 997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNK-------QENDKLKKEIFTLQKDLRDKTV 1049
Query: 422 STEKFNFIEEIKTLK-DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + +E + K DEL ++ + + ++ EK ++E K + + ++++
Sbjct: 1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Query: 481 LTLRLRESDS-------ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNT------VREC 527
+ L + ++ +E L+++++ + E + +T L N + E
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
Query: 528 DEYKEAL---VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
+ KEA V I+K+ +E ++ V+ ++S K+A ++L T + +
Sbjct: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
Query: 585 ELLKKESNSQIKFLREEV 602
+ K + +QI L E++
Sbjct: 1230 KATKSDLETQISSLNEKL 1247
Score = 55.2 bits (127), Expect = 8e-07
Identities = 93/474 (19%), Positives = 200/474 (42%), Gaps = 23/474 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L Q L QD E+ K ++ I+D + E L+E L+++ + R + +
Sbjct: 268 KGPSLQQRNLTHMQD-EVNVKSHQ--REHQNIQDLEIENEDLKERLRKIQQEQRILLDKV 324
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
N + +L++ + + +E ++ A K +R+ I L+ + + +++
Sbjct: 325 --NGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT-IEALKNRFKYFESDHL 381
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
S+ +E + ++ + TS + A Q R + +L + + S
Sbjct: 382 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIP-AHMQSRSMLRPLELSLPSQTSYSENE 440
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL-EQLHS 334
K ELEA++T + KQ + LK ++ + + + + L +CE + E
Sbjct: 441 ILKKELEAMRTFCESAKQ----------DRLKLQNELAHKVAECKALALECERVKEDSDE 490
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI-QEHCSQQEKTIQYLEQEIKEL 393
Q+ E +K +++ ES K+K + F + + E S + + L+ ++K+L
Sbjct: 491 QIKQLEDALKDVQKRMYESEG-KVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL 549
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
K + + + L+ ++ + +E ++ IEE K L+ EL + E + K+
Sbjct: 550 KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 609
Query: 454 NLAVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+A + K S+ + ++ L+ + E +L ++E + + S L+
Sbjct: 610 TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
EL K L V+ +E+++ + + L K+ T + N TL + ++ V
Sbjct: 670 ELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Score = 54.4 bits (125), Expect = 1e-06
Identities = 69/345 (20%), Positives = 150/345 (43%), Gaps = 30/345 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K K N +KK + + + + L++ R + E NKQ++D + +++
Sbjct: 1024 KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK 1083
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ ++L + + + + L K + ++ GT E + + M+
Sbjct: 1084 NVKEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-IENLKEELKSMQ- 1139
Query: 199 RIIELEKKCEALDNEVYDKQMELS-SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
R E E++ +++ + Q S L E + ++++ K++ S E+Q ++E
Sbjct: 1140 RCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
V ++ E + +ALK KL+ + +SK K + +L+T+ ++ E L
Sbjct: 1200 EV-----------SKLQSEVQNTKQALK-KLETREVVDLSKYKATKSDLETQISSLNEKL 1247
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
N L K E + E+ + AK ++I SA ++ ++ E+ + +E C
Sbjct: 1248 AN--LNRKYEE---------VCEEVLHAKKKEI--SAKDEKELLHFSIEQEIKDQKERCD 1294
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
+ TI L++ I+E ++ +N+ ++L ++ LK + LS
Sbjct: 1295 KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1339
Score = 54.0 bits (124), Expect = 2e-06
Identities = 137/625 (21%), Positives = 254/625 (40%), Gaps = 58/625 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E Q++D K + + +L + +Q N + E R KL N E +
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQ--NEMIVEEFKRDEGKLIEENKRLQKELSMC 598
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK 241
+ + EK + +M + EL K AL + SSL + + K L E
Sbjct: 599 E-MEREKKGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEK---AKKLVEM 653
Query: 242 LTSNELTLAETQQ---RLEMVKGHHALAL--EANESI--RREYKI-ELEALKTKLDEEKQ 293
+E +L+E +Q LE VK A + E +E + R E K EL T+L + Q
Sbjct: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 294 AI---ISKCKVDQENLKTK-HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
+ I K +D + LK + HN +IE + + + E +++ H +I ++ KL
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAII---DDLNRKLLD 770
Query: 350 IEESASEK-LKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTLDLTNNQNS 405
+ + +EK L++ ++ E + S+ + S+ E + E+EI LK + Q S
Sbjct: 771 VTQKYTEKKLEMEKLLLE--NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLS 828
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-- 463
+LK++ + L++E N +K + +E K LN + K +E
Sbjct: 829 ELKKKCGEDQEKIHALTSENTN----LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELL 884
Query: 464 --KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
K KFE + ++ V ++++ + L++ + Q A+ + E ++L+
Sbjct: 885 DVKKKFE---DINQEFV-----KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 936
Query: 522 NTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
++R+ D E L N K + + H I L +++Q K Y + + + E
Sbjct: 937 QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL-DTIQECIKVKYAPIVSFE-EC 994
Query: 581 IEDVELLKKESNSQIK-------FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQA 633
+ +KE Q+ EEV+K + + VL+ ++
Sbjct: 995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1054
Query: 634 ---AADLSRLENE-NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
LSR +E N++ + L +EN + T + +++ K L
Sbjct: 1055 HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1114
Query: 690 EQSQYTPKSPSVLRKSLKVGKENMQ 714
EQ + KS + ++LK ++MQ
Sbjct: 1115 EQVEALKKSLNGTIENLKEELKSMQ 1139
>BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 74.9 bits (176), Expect = 9e-13
Identities = 77/392 (19%), Positives = 182/392 (46%), Gaps = 20/392 (5%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM 192
E+ Q ++ L++L + + + E R+L+ L+ + H+ E+ A
Sbjct: 731 ELLQAKQDLQDLLIAKEEQEDLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +R + E K E L + + + + E + + + LQ + E +A+
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q+++E +KG A A E + E + EAL EEK+A+ ++ ++ E + N
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 313 SIESLKNQMLKEKC-------EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
S + + + L EK E L +L +++ + + +E++++ ++ ++
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQNSD----LKQELNNLKNCK 418
E + E+ + + + +++++KE + LT + D +++EL + + +
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
DE T++ + +K L+ EL K+ + ++++++L +E + ++ E L R+
Sbjct: 1029 DEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQMEDKV---SQLEMELEEERNNS 1084
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+L+ R+ S ++EQL +++ +A++ LE
Sbjct: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Score = 59.7 bits (138), Expect = 4e-08
Identities = 110/514 (21%), Positives = 214/514 (41%), Gaps = 38/514 (7%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET---QQRLEMVKGHHALALEANESI- 273
Q+E+ + + + R+ + +L+E + + + E QQRLE +G LE +
Sbjct: 631 QLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 274 --RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL--KNQMLKEKCEAL 329
R +++ E+ L+ +L E + S K ++ K A IE L Q L++ A
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDS-AKRSEDREK---GALIEELLQAKQDLQDLLIAK 746
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
E+ L +E+E+ A ++E S +++ + Q++ Q+++E + K ++ L
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK-DELIEKTI- 444
+ T + L++E L+ +EL +I+ LK DE K
Sbjct: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866
Query: 445 -NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
YE E +L A+ A KE+ + ++ + + L ++ E +QL ++++ +
Sbjct: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
KE +L KN + N + + ++ K+ L KE I+E + T LQ
Sbjct: 927 EQKE----QLRRLKNEMEN-----ERW-----HLGKTIEKLQKEMADIVEASRTSTLELQ 972
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXX 621
N + + Y+E + EL E LK+++ + + +++ + L E
Sbjct: 973 N-QLDEYKEKN--RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 622 XXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
R LL Q DL LE ++ + ++S L E EE S
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
I + ++ +EQ + R+ L+ K +++
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
Score = 57.2 bits (132), Expect = 2e-07
Identities = 85/401 (21%), Positives = 168/401 (41%), Gaps = 21/401 (5%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNE-LTLAETQQRLEMVKGHHALALEANESIRRE 276
Q EL+ T + L L+E T N+ T + E ++ + A + + +
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E +K L+++ + I ++ ++ L+ K+ +I+ + +M + E L H++
Sbjct: 603 CNSTSE-VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM-RANLEELRSQHNE 660
Query: 336 LIIKEQEMKAKLEQIEESASEKL-KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+ + ++ +LE+ E + L ++ +++ ER Q E Q++ + + E+ K
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKM-EREQHQTEIRDLQDQ-LSEMHDELDSAK 718
Query: 395 YTLDLTN----NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+ D + KQ+L +L K+E E+ LK L E+ +++ E
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+KL E+ E S+ V VL R S+ + E +V++L E L+
Sbjct: 779 DKLK---EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+ + R+ ++ K + K+K L K I + L+ + + EKEA
Sbjct: 836 GRSEELERRVAQLQRQIEDLKG---DEAKAKETLKKYEGEIRQLEEALVHA-RKEEKEAV 891
Query: 571 RELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
++NEL L + + Q + L+EE E+K L
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL 932
Score = 50.4 bits (115), Expect = 2e-05
Identities = 81/397 (20%), Positives = 160/397 (40%), Gaps = 28/397 (7%)
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFE 366
TK ++ K Q LK + Q ++Q E+K LEQ + E ++ ++Q E
Sbjct: 574 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLE 633
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKE-------LKYTLDLTNNQNSDLKQELNNLKNCK 418
+ Q+I+E + ++ L + E L+ L+ + + +EL +K +
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
++ TE + +++ + DEL + + EK L +E+ ++ K + L +
Sbjct: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL---IEELLQAKQDLQDLLIAKEEQE 750
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV--- 535
+L R RE + L+++V + L+ + L +V E + E L
Sbjct: 751 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
N + A T+ ++++ E LQ +E R + ++ + IED++ + ++ +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEE---NEKLQGRSEELERRVAQLQRQ-IEDLKGDEAKAKETL 866
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL---LAQAAADLSRLENENERYXXXXX 652
K E+ R L E R L L A +LS+ E ++
Sbjct: 867 KKYEGEI---RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
+L L+ E E + K I+KL+K++
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGK---TIEKLQKEM 957
Score = 48.0 bits (109), Expect = 1e-04
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 30/358 (8%)
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ------EIKELKYTLDLTNNQNSDLKQ 409
EK++ + + +Q + C+ + LEQ E+ EL+ L L ++K+
Sbjct: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
E ++ +EL ++ +EE TL+ L E + +L +E+ + K + E
Sbjct: 643 ERERMRANLEELRSQHNEKVEENSTLQQRL-------EESEGELRKNLEELFQVKMEREQ 695
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKEVLENELTTYKNTLNNTV 524
+ RD+ L+ E DS ++ ED+ ++ L AK+ L+ +L K + +
Sbjct: 696 HQTEIRDLQDQLSEMHDELDS-AKRSEDREKGALIEELLQAKQDLQ-DLLIAKEEQEDLL 753
Query: 525 RECDEYKEALVNILKSK-AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
R+ + AL LK + ++ +E ++ E +++L+ +EA + + + +
Sbjct: 754 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR-SNT 812
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E + + ++K L+EE EK + E + A+A L + E E
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 644 NERYXXXXXXXXSLVVELSLLRQ--ENE------ELTMTVAKQSSIIDKLKKDLEQSQ 693
+ E R+ ENE L+ T +Q + +KLK++ EQ +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Score = 45.6 bits (103), Expect = 6e-04
Identities = 60/312 (19%), Positives = 132/312 (42%), Gaps = 29/312 (9%)
Query: 125 KQIEDYKNEIAQLQEILK----ELATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEH 178
K IE + E+A + E + EL + + N + E+ R+L + +
Sbjct: 948 KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 1007
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+Q + + + D + E K + L+ + D + EL + + R L K +
Sbjct: 1008 MKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM 1066
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY------KIELEALKTKLDEEK 292
++K++ E+ L E + +++ + + E E +R E + +LE K L+ +
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
Query: 293 QAIISKC-------KVDQENLKTKHNASIESLKNQMLKEKCEA---------LEQLHSQL 336
+ + S+ + +E L + A I L++++ E+ + LE+ +L
Sbjct: 1127 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL 1186
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
+++ + L ++ S +LK + Q EE + I S ++K + LE+++ ++
Sbjct: 1187 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 1246
Query: 397 LDLTNNQNSDLK 408
N+ DL+
Sbjct: 1247 QGQLNSMKKDLR 1258
Score = 44.0 bits (99), Expect = 0.002
Identities = 55/285 (19%), Positives = 140/285 (49%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL-LEQT 1041
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER----NNSDLLSERI-SRSRE 1096
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E L+N++L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 1097 QMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 1156
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 1260
>BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 74.9 bits (176), Expect = 9e-13
Identities = 77/392 (19%), Positives = 182/392 (46%), Gaps = 20/392 (5%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM 192
E+ Q ++ L++L + + + E R+L+ L+ + H+ E+ A
Sbjct: 731 ELLQAKQDLQDLLIAKEEQEDLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +R + E K E L + + + + E + + + LQ + E +A+
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q+++E +KG A A E + E + EAL EEK+A+ ++ ++ E + N
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 313 SIESLKNQMLKEKC-------EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
S + + + L EK E L +L +++ + + +E++++ ++ ++
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQNSD----LKQELNNLKNCK 418
E + E+ + + + +++++KE + LT + D +++EL + + +
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
DE T++ + +K L+ EL K+ + ++++++L +E + ++ E L R+
Sbjct: 1029 DEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQMEDKV---SQLEMELEEERNNS 1084
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+L+ R+ S ++EQL +++ +A++ LE
Sbjct: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Score = 59.7 bits (138), Expect = 4e-08
Identities = 110/514 (21%), Positives = 214/514 (41%), Gaps = 38/514 (7%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET---QQRLEMVKGHHALALEANESI- 273
Q+E+ + + + R+ + +L+E + + + E QQRLE +G LE +
Sbjct: 631 QLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 274 --RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL--KNQMLKEKCEAL 329
R +++ E+ L+ +L E + S K ++ K A IE L Q L++ A
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDS-AKRSEDREK---GALIEELLQAKQDLQDLLIAK 746
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
E+ L +E+E+ A ++E S +++ + Q++ Q+++E + K ++ L
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK-DELIEKTI- 444
+ T + L++E L+ +EL +I+ LK DE K
Sbjct: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866
Query: 445 -NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
YE E +L A+ A KE+ + ++ + + L ++ E +QL ++++ +
Sbjct: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
KE +L KN + N + + ++ K+ L KE I+E + T LQ
Sbjct: 927 EQKE----QLRRLKNEMEN-----ERW-----HLGKTIEKLQKEMADIVEASRTSTLELQ 972
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXX 621
N + + Y+E + EL E LK+++ + + +++ + L E
Sbjct: 973 N-QLDEYKEKN--RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 622 XXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
R LL Q DL LE ++ + ++S L E EE S
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
I + ++ +EQ + R+ L+ K +++
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
Score = 57.2 bits (132), Expect = 2e-07
Identities = 85/401 (21%), Positives = 168/401 (41%), Gaps = 21/401 (5%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNE-LTLAETQQRLEMVKGHHALALEANESIRRE 276
Q EL+ T + L L+E T N+ T + E ++ + A + + +
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E +K L+++ + I ++ ++ L+ K+ +I+ + +M + E L H++
Sbjct: 603 CNSTSE-VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM-RANLEELRSQHNE 660
Query: 336 LIIKEQEMKAKLEQIEESASEKL-KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+ + ++ +LE+ E + L ++ +++ ER Q E Q++ + + E+ K
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKM-EREQHQTEIRDLQDQ-LSEMHDELDSAK 718
Query: 395 YTLDLTN----NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+ D + KQ+L +L K+E E+ LK L E+ +++ E
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+KL E+ E S+ V VL R S+ + E +V++L E L+
Sbjct: 779 DKLK---EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+ + R+ ++ K + K+K L K I + L+ + + EKEA
Sbjct: 836 GRSEELERRVAQLQRQIEDLKG---DEAKAKETLKKYEGEIRQLEEALVHA-RKEEKEAV 891
Query: 571 RELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
++NEL L + + Q + L+EE E+K L
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL 932
Score = 50.4 bits (115), Expect = 2e-05
Identities = 81/397 (20%), Positives = 160/397 (40%), Gaps = 28/397 (7%)
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFE 366
TK ++ K Q LK + Q ++Q E+K LEQ + E ++ ++Q E
Sbjct: 574 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLE 633
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKE-------LKYTLDLTNNQNSDLKQELNNLKNCK 418
+ Q+I+E + ++ L + E L+ L+ + + +EL +K +
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
++ TE + +++ + DEL + + EK L +E+ ++ K + L +
Sbjct: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL---IEELLQAKQDLQDLLIAKEEQE 750
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV--- 535
+L R RE + L+++V + L+ + L +V E + E L
Sbjct: 751 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
N + A T+ ++++ E LQ +E R + ++ + IED++ + ++ +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEE---NEKLQGRSEELERRVAQLQRQ-IEDLKGDEAKAKETL 866
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL---LAQAAADLSRLENENERYXXXXX 652
K E+ R L E R L L A +LS+ E ++
Sbjct: 867 KKYEGEI---RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
+L L+ E E + K I+KL+K++
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGK---TIEKLQKEM 957
Score = 48.0 bits (109), Expect = 1e-04
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 30/358 (8%)
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ------EIKELKYTLDLTNNQNSDLKQ 409
EK++ + + +Q + C+ + LEQ E+ EL+ L L ++K+
Sbjct: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
E ++ +EL ++ +EE TL+ L E + +L +E+ + K + E
Sbjct: 643 ERERMRANLEELRSQHNEKVEENSTLQQRL-------EESEGELRKNLEELFQVKMEREQ 695
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKEVLENELTTYKNTLNNTV 524
+ RD+ L+ E DS ++ ED+ ++ L AK+ L+ +L K + +
Sbjct: 696 HQTEIRDLQDQLSEMHDELDS-AKRSEDREKGALIEELLQAKQDLQ-DLLIAKEEQEDLL 753
Query: 525 RECDEYKEALVNILKSK-AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
R+ + AL LK + ++ +E ++ E +++L+ +EA + + + +
Sbjct: 754 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR-SNT 812
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E + + ++K L+EE EK + E + A+A L + E E
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 644 NERYXXXXXXXXSLVVELSLLRQ--ENE------ELTMTVAKQSSIIDKLKKDLEQSQ 693
+ E R+ ENE L+ T +Q + +KLK++ EQ +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Score = 45.6 bits (103), Expect = 6e-04
Identities = 60/312 (19%), Positives = 132/312 (42%), Gaps = 29/312 (9%)
Query: 125 KQIEDYKNEIAQLQEILK----ELATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEH 178
K IE + E+A + E + EL + + N + E+ R+L + +
Sbjct: 948 KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 1007
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+Q + + + D + E K + L+ + D + EL + + R L K +
Sbjct: 1008 MKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM 1066
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY------KIELEALKTKLDEEK 292
++K++ E+ L E + +++ + + E E +R E + +LE K L+ +
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
Query: 293 QAIISKC-------KVDQENLKTKHNASIESLKNQMLKEKCEA---------LEQLHSQL 336
+ + S+ + +E L + A I L++++ E+ + LE+ +L
Sbjct: 1127 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL 1186
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
+++ + L ++ S +LK + Q EE + I S ++K + LE+++ ++
Sbjct: 1187 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 1246
Query: 397 LDLTNNQNSDLK 408
N+ DL+
Sbjct: 1247 QGQLNSMKKDLR 1258
Score = 44.0 bits (99), Expect = 0.002
Identities = 55/285 (19%), Positives = 140/285 (49%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL-LEQT 1041
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER----NNSDLLSERI-SRSRE 1096
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E L+N++L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 1097 QMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 1156
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 1260
>AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein.
Length = 1302
Score = 74.9 bits (176), Expect = 9e-13
Identities = 77/392 (19%), Positives = 182/392 (46%), Gaps = 20/392 (5%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM 192
E+ Q ++ L++L + + + E R+L+ L+ + H+ E+ A
Sbjct: 731 ELLQAKQDLQDLLIAKEEQEDLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +R + E K E L + + + + E + + + LQ + E +A+
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q+++E +KG A A E + E + EAL EEK+A+ ++ ++ E + N
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 313 SIESLKNQMLKEKC-------EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
S + + + L EK E L +L +++ + + +E++++ ++ ++
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQNSD----LKQELNNLKNCK 418
E + E+ + + + +++++KE + LT + D +++EL + + +
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
DE T++ + +K L+ EL K+ + ++++++L +E + ++ E L R+
Sbjct: 1029 DEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQMEDKV---SQLEMELEEERNNS 1084
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+L+ R+ S ++EQL +++ +A++ LE
Sbjct: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Score = 59.7 bits (138), Expect = 4e-08
Identities = 110/514 (21%), Positives = 214/514 (41%), Gaps = 38/514 (7%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET---QQRLEMVKGHHALALEANESI- 273
Q+E+ + + + R+ + +L+E + + + E QQRLE +G LE +
Sbjct: 631 QLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 274 --RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL--KNQMLKEKCEAL 329
R +++ E+ L+ +L E + S K ++ K A IE L Q L++ A
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDS-AKRSEDREK---GALIEELLQAKQDLQDLLIAK 746
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
E+ L +E+E+ A ++E S +++ + Q++ Q+++E + K ++ L
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK-DELIEKTI- 444
+ T + L++E L+ +EL +I+ LK DE K
Sbjct: 807 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866
Query: 445 -NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
YE E +L A+ A KE+ + ++ + + L ++ E +QL ++++ +
Sbjct: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
KE +L KN + N + + ++ K+ L KE I+E + T LQ
Sbjct: 927 EQKE----QLRRLKNEMEN-----ERW-----HLGKTIEKLQKEMADIVEASRTSTLELQ 972
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXX 621
N + + Y+E + EL E LK+++ + + +++ + L E
Sbjct: 973 N-QLDEYKEKN--RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 622 XXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
R LL Q DL LE ++ + ++S L E EE S
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
I + ++ +EQ + R+ L+ K +++
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLE 1123
Score = 57.2 bits (132), Expect = 2e-07
Identities = 85/401 (21%), Positives = 168/401 (41%), Gaps = 21/401 (5%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNE-LTLAETQQRLEMVKGHHALALEANESIRRE 276
Q EL+ T + L L+E T N+ T + E ++ + A + + +
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E +K L+++ + I ++ ++ L+ K+ +I+ + +M + E L H++
Sbjct: 603 CNSTSE-VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM-RANLEELRSQHNE 660
Query: 336 LIIKEQEMKAKLEQIEESASEKL-KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+ + ++ +LE+ E + L ++ +++ ER Q E Q++ + + E+ K
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKM-EREQHQTEIRDLQDQ-LSEMHDELDSAK 718
Query: 395 YTLDLTN----NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+ D + KQ+L +L K+E E+ LK L E+ +++ E
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+KL E+ E S+ V VL R S+ + E +V++L E L+
Sbjct: 779 DKLK---EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+ + R+ ++ K + K+K L K I + L+ + + EKEA
Sbjct: 836 GRSEELERRVAQLQRQIEDLKG---DEAKAKETLKKYEGEIRQLEEALVHA-RKEEKEAV 891
Query: 571 RELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
++NEL L + + Q + L+EE E+K L
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL 932
Score = 50.4 bits (115), Expect = 2e-05
Identities = 81/397 (20%), Positives = 160/397 (40%), Gaps = 28/397 (7%)
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFE 366
TK ++ K Q LK + Q ++Q E+K LEQ + E ++ ++Q E
Sbjct: 574 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLE 633
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKE-------LKYTLDLTNNQNSDLKQELNNLKNCK 418
+ Q+I+E + ++ L + E L+ L+ + + +EL +K +
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
++ TE + +++ + DEL + + EK L +E+ ++ K + L +
Sbjct: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL---IEELLQAKQDLQDLLIAKEEQE 750
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV--- 535
+L R RE + L+++V + L+ + L +V E + E L
Sbjct: 751 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
N + A T+ ++++ E LQ +E R + ++ + IED++ + ++ +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEE---NEKLQGRSEELERRVAQLQRQ-IEDLKGDEAKAKETL 866
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL---LAQAAADLSRLENENERYXXXXX 652
K E+ R L E R L L A +LS+ E ++
Sbjct: 867 KKYEGEI---RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
+L L+ E E + K I+KL+K++
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGK---TIEKLQKEM 957
Score = 48.0 bits (109), Expect = 1e-04
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 30/358 (8%)
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ------EIKELKYTLDLTNNQNSDLKQ 409
EK++ + + +Q + C+ + LEQ E+ EL+ L L ++K+
Sbjct: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
E ++ +EL ++ +EE TL+ L E + +L +E+ + K + E
Sbjct: 643 ERERMRANLEELRSQHNEKVEENSTLQQRL-------EESEGELRKNLEELFQVKMEREQ 695
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKEVLENELTTYKNTLNNTV 524
+ RD+ L+ E DS ++ ED+ ++ L AK+ L+ +L K + +
Sbjct: 696 HQTEIRDLQDQLSEMHDELDS-AKRSEDREKGALIEELLQAKQDLQ-DLLIAKEEQEDLL 753
Query: 525 RECDEYKEALVNILKSK-AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
R+ + AL LK + ++ +E ++ E +++L+ +EA + + + +
Sbjct: 754 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR-SNT 812
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E + + ++K L+EE EK + E + A+A L + E E
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 644 NERYXXXXXXXXSLVVELSLLRQ--ENE------ELTMTVAKQSSIIDKLKKDLEQSQ 693
+ E R+ ENE L+ T +Q + +KLK++ EQ +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Score = 45.6 bits (103), Expect = 6e-04
Identities = 60/312 (19%), Positives = 132/312 (42%), Gaps = 29/312 (9%)
Query: 125 KQIEDYKNEIAQLQEILK----ELATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEH 178
K IE + E+A + E + EL + + N + E+ R+L + +
Sbjct: 948 KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 1007
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+Q + + + D + E K + L+ + D + EL + + R L K +
Sbjct: 1008 MKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM 1066
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY------KIELEALKTKLDEEK 292
++K++ E+ L E + +++ + + E E +R E + +LE K L+ +
Sbjct: 1067 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQN 1126
Query: 293 QAIISKC-------KVDQENLKTKHNASIESLKNQMLKEKCEA---------LEQLHSQL 336
+ + S+ + +E L + A I L++++ E+ + LE+ +L
Sbjct: 1127 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL 1186
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
+++ + L ++ S +LK + Q EE + I S ++K + LE+++ ++
Sbjct: 1187 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 1246
Query: 397 LDLTNNQNSDLK 408
N+ DL+
Sbjct: 1247 QGQLNSMKKDLR 1258
Score = 44.0 bits (99), Expect = 0.002
Identities = 55/285 (19%), Positives = 140/285 (49%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL-LEQT 1041
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER----NNSDLLSERI-SRSRE 1096
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E L+N++L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 1097 QMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 1156
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 1260
>AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein.
Length = 1416
Score = 74.9 bits (176), Expect = 9e-13
Identities = 112/477 (23%), Positives = 224/477 (46%), Gaps = 46/477 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KN+IL ++ L Q+ +I+ + ++ E+ ++ + ++Q+ E+ +R+ I
Sbjct: 903 KNEILKRN-LENTQN-QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
Query: 156 DFNEIDRKLSKLRINNTN-CHTEHNA--VQGTDAE-KVSAMINDMRSRIIELEKKCEALD 211
+ K K ++ C A V + E K A +++ ++ E +K +
Sbjct: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLT----SNELTLAETQQRLEMVKGHHALAL 267
EV + E L++ I +L KDL++K S+E+ A +++ E+ K L+
Sbjct: 1021 EEVKKNKQENDKLKKEIF---TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 268 EANESIR-REYKIELEALKTKLDEEKQAIISKCKVDQEN---LKTKHNASIESLKNQMLK 323
+ E +E +E A +T Q ++ K V E LK N +IE+LK ++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKS 1137
Query: 324 -EKCEALEQ-----LHSQLIIKEQEMKAKLE---QIEESASEKLKICEIQF---EERSQS 371
++C EQ LH QL+ ++ L QI+E+ +++ I + EE SQ+
Sbjct: 1138 MQRCYEKEQQTVTKLH-QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQN 1196
Query: 372 IQEHCSQQEKTIQYLEQEIKEL--KYTLDLTNNQ--NSDLKQELNNLKNCKDELSTEKFN 427
E S+ + +Q +Q +K+L + +DL+ + SDL+ ++++L L+ +
Sbjct: 1197 KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1256
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLR 486
EE+ K +K I+ ++EK L+ ++E+ IK +K + + SL+ + L R++
Sbjct: 1257 VCEEVLHAK----KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITE----LQRRIQ 1308
Query: 487 ESDSELEQLEDQVQMLTSAKEVLE---NELTTYKNTLNNTVRECDEYKEALVNILKS 540
ES ++E ++++ L + E L+ N L+ T N + + + L + +KS
Sbjct: 1309 ESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKS 1365
Score = 69.3 bits (162), Expect = 4e-11
Identities = 114/539 (21%), Positives = 232/539 (43%), Gaps = 34/539 (6%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEIL 141
+A S K L+ P K + + + E+ K + + E ++ E +EI QL+ L
Sbjct: 615 QAKELSAKLALSIPAEKF---ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
Query: 142 KELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ + K Q + ++ +L + TE T +++ + D +
Sbjct: 672 ENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL--- 728
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
L+++ L E+ + + L E++ D++ DL KL ++T T+++LEM K
Sbjct: 729 -LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLL--DVTQKYTEKKLEMEK- 784
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIIS------KCKVDQENLKTKHNASIE 315
L LE N+S+ ++ LE + ++ ++ II+ + K LK K E
Sbjct: 785 ---LLLE-NDSLSKDVS-RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
Query: 316 SLKNQMLKEKCEALEQLHSQLI-IK-EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+ + + E + + +Q + +K +E+K L + +L + +FE+ +Q
Sbjct: 840 KI-HALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898
Query: 374 EHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
+ + E + ++ + +IK +L + S L Q + +++ E+ E
Sbjct: 899 KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958
Query: 431 EIKTLKDELI--EKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRE 487
EI TL E+ +K ++ E K+ A + +E + KF+ + +D + T +
Sbjct: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTK 546
S+ E+++ + + L L+ +L K L E + + L K L++
Sbjct: 1019 SEEEVKKNKQENDKLKKEIFTLQKDLRD-KTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 547 EHTRIMEHNVTLIE--SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++T + L+E + Q E A + L ++ +E VE LKK N I+ L+EE++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK 1136
Score = 65.7 bits (153), Expect = 5e-10
Identities = 94/436 (21%), Positives = 184/436 (42%), Gaps = 28/436 (6%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHTEHNA 180
++ K+I K+ I +L++ L EL K + I + L K+ N H
Sbjct: 808 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE 867
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
V+ T ++ + +++++KK E ++ E +++ E++ + +L ++ Q
Sbjct: 868 VKMT----LNDTLAKTNRELLDVKKKFEDINQEF----VKIKDKNEIL--KRNL-ENTQN 916
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCK 300
++ + ++LAE + ++ + ++N I Y+ E + T L E +A +
Sbjct: 917 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVT-LHAEIKAQKKELD 975
Query: 301 VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
QE +K K+ A I S + K K E L QL + Q+ E+++++ E K+
Sbjct: 976 TIQECIKVKY-APIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
+ F ++Q+ + I+ + + L D N Q DL Q+ +KN K++
Sbjct: 1034 KKEIF-----TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE---KNKLNLAVEKAIKEKNKFETSLSVTRDI 477
L E EI +++ L ++ + E K LN +E +E + +
Sbjct: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
V L L + L + +Q+ KE E E+ K +L E E V+
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQI----KEAFEKEVGIIKASLREKEEESQNKMEE-VSK 1203
Query: 538 LKSKAALTKEHTRIME 553
L+S+ TK+ + +E
Sbjct: 1204 LQSEVQNTKQALKKLE 1219
Score = 63.3 bits (147), Expect = 3e-09
Identities = 87/438 (19%), Positives = 208/438 (47%), Gaps = 38/438 (8%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE-KLTSNELTLAE 251
I +++ ++ EL+KKC +++ E ++L+++++ + K +E K+T N+ TLA+
Sbjct: 820 IVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND-TLAK 878
Query: 252 TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD------QEN 305
T + L VK + I+ + +I L+ ++ K IS + + ++
Sbjct: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLE--QIEESASEKLKICEI 363
++ +++ E L N ++ E + LH+++ +++E+ E +++ + + CE
Sbjct: 939 MRKVQDSNAEILANY--RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER 996
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-L 421
+F+ + +++ S+Q + E+E+K+ K +N LK+E+ L K+ +D+ +
Sbjct: 997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNK-------QENDKLKKEIFTLQKDLRDKTV 1049
Query: 422 STEKFNFIEEIKTLK-DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + +E + K DEL ++ + + ++ EK ++E K + + ++++
Sbjct: 1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Query: 481 LTLRLRESDS-------ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNT------VREC 527
+ L + ++ +E L+++++ + E + +T L N + E
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
Query: 528 DEYKEAL---VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
+ KEA V I+K+ +E ++ V+ ++S K+A ++L T + +
Sbjct: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
Query: 585 ELLKKESNSQIKFLREEV 602
+ K + +QI L E++
Sbjct: 1230 KATKSDLETQISSLNEKL 1247
Score = 55.2 bits (127), Expect = 8e-07
Identities = 93/474 (19%), Positives = 200/474 (42%), Gaps = 23/474 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L Q L QD E+ K ++ I+D + E L+E L+++ + R + +
Sbjct: 268 KGPSLQQRNLTHMQD-EVNVKSHQ--REHQNIQDLEIENEDLKERLRKIQQEQRILLDKV 324
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
N + +L++ + + +E ++ A K +R+ I L+ + + +++
Sbjct: 325 --NGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT-IEALKNRFKYFESDHL 381
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
S+ +E + ++ + TS + A Q R + +L + + S
Sbjct: 382 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIP-AHMQSRSMLRPLELSLPSQTSYSENE 440
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL-EQLHS 334
K ELEA++T + KQ + LK ++ + + + + L +CE + E
Sbjct: 441 ILKKELEAMRTFCESAKQ----------DRLKLQNELAHKVAECKALALECERVKEDSDE 490
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI-QEHCSQQEKTIQYLEQEIKEL 393
Q+ E +K +++ ES K+K + F + + E S + + L+ ++K+L
Sbjct: 491 QIKQLEDALKDVQKRMYESEG-KVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL 549
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
K + + + L+ ++ + +E ++ IEE K L+ EL + E + K+
Sbjct: 550 KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 609
Query: 454 NLAVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+A + K S+ + ++ L+ + E +L ++E + + S L+
Sbjct: 610 TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
EL K L V+ +E+++ + + L K+ T + N TL + ++ V
Sbjct: 670 ELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Score = 54.4 bits (125), Expect = 1e-06
Identities = 69/345 (20%), Positives = 150/345 (43%), Gaps = 30/345 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K K N +KK + + + + L++ R + E NKQ++D + +++
Sbjct: 1024 KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK 1083
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ ++L + + + + L K + ++ GT E + + M+
Sbjct: 1084 NVKEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-IENLKEELKSMQ- 1139
Query: 199 RIIELEKKCEALDNEVYDKQMELS-SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
R E E++ +++ + Q S L E + ++++ K++ S E+Q ++E
Sbjct: 1140 RCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
V ++ E + +ALK KL+ + +SK K + +L+T+ ++ E L
Sbjct: 1200 EV-----------SKLQSEVQNTKQALK-KLETREVVDLSKYKATKSDLETQISSLNEKL 1247
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
N L K E + E+ + AK ++I SA ++ ++ E+ + +E C
Sbjct: 1248 AN--LNRKYEE---------VCEEVLHAKKKEI--SAKDEKELLHFSIEQEIKDQKERCD 1294
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
+ TI L++ I+E ++ +N+ ++L ++ LK + LS
Sbjct: 1295 KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1339
Score = 54.0 bits (124), Expect = 2e-06
Identities = 137/625 (21%), Positives = 254/625 (40%), Gaps = 58/625 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E Q++D K + + +L + +Q N + E R KL N E +
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQ--NEMIVEEFKRDEGKLIEENKRLQKELSMC 598
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK 241
+ + EK + +M + EL K AL + SSL + + K L E
Sbjct: 599 E-MEREKKGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEK---AKKLVEM 653
Query: 242 LTSNELTLAETQQ---RLEMVKGHHALAL--EANESI--RREYKI-ELEALKTKLDEEKQ 293
+E +L+E +Q LE VK A + E +E + R E K EL T+L + Q
Sbjct: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 294 AI---ISKCKVDQENLKTK-HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
+ I K +D + LK + HN +IE + + + E +++ H +I ++ KL
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAII---DDLNRKLLD 770
Query: 350 IEESASEK-LKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTLDLTNNQNS 405
+ + +EK L++ ++ E + S+ + S+ E + E+EI LK + Q S
Sbjct: 771 VTQKYTEKKLEMEKLLLE--NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLS 828
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-- 463
+LK++ + L++E N +K + +E K LN + K +E
Sbjct: 829 ELKKKCGEDQEKIHALTSENTN----LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELL 884
Query: 464 --KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
K KFE + ++ V ++++ + L++ + Q A+ + E ++L+
Sbjct: 885 DVKKKFE---DINQEFV-----KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 936
Query: 522 NTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
++R+ D E L N K + + H I L +++Q K Y + + + E
Sbjct: 937 QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL-DTIQECIKVKYAPIVSFE-EC 994
Query: 581 IEDVELLKKESNSQIK-------FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQA 633
+ +KE Q+ EEV+K + + VL+ ++
Sbjct: 995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1054
Query: 634 ---AADLSRLENE-NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
LSR +E N++ + L +EN + T + +++ K L
Sbjct: 1055 HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1114
Query: 690 EQSQYTPKSPSVLRKSLKVGKENMQ 714
EQ + KS + ++LK ++MQ
Sbjct: 1115 EQVEALKKSLNGTIENLKEELKSMQ 1139
>AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein.
Length = 1416
Score = 74.9 bits (176), Expect = 9e-13
Identities = 112/477 (23%), Positives = 224/477 (46%), Gaps = 46/477 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
KN+IL ++ L Q+ +I+ + ++ E+ ++ + ++Q+ E+ +R+ I
Sbjct: 903 KNEILKRN-LENTQN-QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
Query: 156 DFNEIDRKLSKLRINNTN-CHTEHNA--VQGTDAE-KVSAMINDMRSRIIELEKKCEALD 211
+ K K ++ C A V + E K A +++ ++ E +K +
Sbjct: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLT----SNELTLAETQQRLEMVKGHHALAL 267
EV + E L++ I +L KDL++K S+E+ A +++ E+ K L+
Sbjct: 1021 EEVKKNKQENDKLKKEIF---TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 268 EANESIR-REYKIELEALKTKLDEEKQAIISKCKVDQEN---LKTKHNASIESLKNQMLK 323
+ E +E +E A +T Q ++ K V E LK N +IE+LK ++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKS 1137
Query: 324 -EKCEALEQ-----LHSQLIIKEQEMKAKLE---QIEESASEKLKICEIQF---EERSQS 371
++C EQ LH QL+ ++ L QI+E+ +++ I + EE SQ+
Sbjct: 1138 MQRCYEKEQQTVTKLH-QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQN 1196
Query: 372 IQEHCSQQEKTIQYLEQEIKEL--KYTLDLTNNQ--NSDLKQELNNLKNCKDELSTEKFN 427
E S+ + +Q +Q +K+L + +DL+ + SDL+ ++++L L+ +
Sbjct: 1197 KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1256
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLR 486
EE+ K +K I+ ++EK L+ ++E+ IK +K + + SL+ + L R++
Sbjct: 1257 VCEEVLHAK----KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITE----LQRRIQ 1308
Query: 487 ESDSELEQLEDQVQMLTSAKEVLE---NELTTYKNTLNNTVRECDEYKEALVNILKS 540
ES ++E ++++ L + E L+ N L+ T N + + + L + +KS
Sbjct: 1309 ESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKS 1365
Score = 69.3 bits (162), Expect = 4e-11
Identities = 114/539 (21%), Positives = 232/539 (43%), Gaps = 34/539 (6%)
Query: 82 KAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEIL 141
+A S K L+ P K + + + E+ K + + E ++ E +EI QL+ L
Sbjct: 615 QAKELSAKLALSIPAEKF---ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
Query: 142 KELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ + K Q + ++ +L + TE T +++ + D +
Sbjct: 672 ENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL--- 728
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
L+++ L E+ + + L E++ D++ DL KL ++T T+++LEM K
Sbjct: 729 -LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLL--DVTQKYTEKKLEMEK- 784
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIIS------KCKVDQENLKTKHNASIE 315
L LE N+S+ ++ LE + ++ ++ II+ + K LK K E
Sbjct: 785 ---LLLE-NDSLSKDVS-RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
Query: 316 SLKNQMLKEKCEALEQLHSQLI-IK-EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
+ + + E + + +Q + +K +E+K L + +L + +FE+ +Q
Sbjct: 840 KI-HALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898
Query: 374 EHCSQQE---KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
+ + E + ++ + +IK +L + S L Q + +++ E+ E
Sbjct: 899 KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958
Query: 431 EIKTLKDELI--EKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRE 487
EI TL E+ +K ++ E K+ A + +E + KF+ + +D + T +
Sbjct: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTK 546
S+ E+++ + + L L+ +L K L E + + L K L++
Sbjct: 1019 SEEEVKKNKQENDKLKKEIFTLQKDLRD-KTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1077
Query: 547 EHTRIMEHNVTLIE--SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
++T + L+E + Q E A + L ++ +E VE LKK N I+ L+EE++
Sbjct: 1078 KYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK 1136
Score = 65.7 bits (153), Expect = 5e-10
Identities = 94/436 (21%), Positives = 184/436 (42%), Gaps = 28/436 (6%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHTEHNA 180
++ K+I K+ I +L++ L EL K + I + L K+ N H
Sbjct: 808 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE 867
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
V+ T ++ + +++++KK E ++ E +++ E++ + +L ++ Q
Sbjct: 868 VKMT----LNDTLAKTNRELLDVKKKFEDINQEF----VKIKDKNEIL--KRNL-ENTQN 916
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCK 300
++ + ++LAE + ++ + ++N I Y+ E + T L E +A +
Sbjct: 917 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVT-LHAEIKAQKKELD 975
Query: 301 VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
QE +K K+ A I S + K K E L QL + Q+ E+++++ E K+
Sbjct: 976 TIQECIKVKY-APIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
+ F ++Q+ + I+ + + L D N Q DL Q+ +KN K++
Sbjct: 1034 KKEIF-----TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENE---KNKLNLAVEKAIKEKNKFETSLSVTRDI 477
L E EI +++ L ++ + E K LN +E +E + +
Sbjct: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
V L L + L + +Q+ KE E E+ K +L E E V+
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQI----KEAFEKEVGIIKASLREKEEESQNKMEE-VSK 1203
Query: 538 LKSKAALTKEHTRIME 553
L+S+ TK+ + +E
Sbjct: 1204 LQSEVQNTKQALKKLE 1219
Score = 63.3 bits (147), Expect = 3e-09
Identities = 87/438 (19%), Positives = 208/438 (47%), Gaps = 38/438 (8%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE-KLTSNELTLAE 251
I +++ ++ EL+KKC +++ E ++L+++++ + K +E K+T N+ TLA+
Sbjct: 820 IVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND-TLAK 878
Query: 252 TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD------QEN 305
T + L VK + I+ + +I L+ ++ K IS + + ++
Sbjct: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLE--QIEESASEKLKICEI 363
++ +++ E L N ++ E + LH+++ +++E+ E +++ + + CE
Sbjct: 939 MRKVQDSNAEILANY--RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER 996
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL-KNCKDE-L 421
+F+ + +++ S+Q + E+E+K+ K +N LK+E+ L K+ +D+ +
Sbjct: 997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNK-------QENDKLKKEIFTLQKDLRDKTV 1049
Query: 422 STEKFNFIEEIKTLK-DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + +E + K DEL ++ + + ++ EK ++E K + + ++++
Sbjct: 1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Query: 481 LTLRLRESDS-------ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNT------VREC 527
+ L + ++ +E L+++++ + E + +T L N + E
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
Query: 528 DEYKEAL---VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
+ KEA V I+K+ +E ++ V+ ++S K+A ++L T + +
Sbjct: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
Query: 585 ELLKKESNSQIKFLREEV 602
+ K + +QI L E++
Sbjct: 1230 KATKSDLETQISSLNEKL 1247
Score = 55.2 bits (127), Expect = 8e-07
Identities = 93/474 (19%), Positives = 200/474 (42%), Gaps = 23/474 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L Q L QD E+ K ++ I+D + E L+E L+++ + R + +
Sbjct: 268 KGPSLQQRNLTHMQD-EVNVKSHQ--REHQNIQDLEIENEDLKERLRKIQQEQRILLDKV 324
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
N + +L++ + + +E ++ A K +R+ I L+ + + +++
Sbjct: 325 --NGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT-IEALKNRFKYFESDHL 381
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR 275
S+ +E + ++ + TS + A Q R + +L + + S
Sbjct: 382 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIP-AHMQSRSMLRPLELSLPSQTSYSENE 440
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEAL-EQLHS 334
K ELEA++T + KQ + LK ++ + + + + L +CE + E
Sbjct: 441 ILKKELEAMRTFCESAKQ----------DRLKLQNELAHKVAECKALALECERVKEDSDE 490
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI-QEHCSQQEKTIQYLEQEIKEL 393
Q+ E +K +++ ES K+K + F + + E S + + L+ ++K+L
Sbjct: 491 QIKQLEDALKDVQKRMYESEG-KVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL 549
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
K + + + L+ ++ + +E ++ IEE K L+ EL + E + K+
Sbjct: 550 KVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 609
Query: 454 NLAVEKAIKEKNKFETSLSVTR--DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
+A + K S+ + ++ L+ + E +L ++E + + S L+
Sbjct: 610 TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
EL K L V+ +E+++ + + L K+ T + N TL + ++ V
Sbjct: 670 ELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Score = 54.4 bits (125), Expect = 1e-06
Identities = 69/345 (20%), Positives = 150/345 (43%), Gaps = 30/345 (8%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K K N +KK + + + + L++ R + E NKQ++D + +++
Sbjct: 1024 KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK 1083
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ ++L + + + + L K + ++ GT E + + M+
Sbjct: 1084 NVKEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT-IENLKEELKSMQ- 1139
Query: 199 RIIELEKKCEALDNEVYDKQMELS-SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
R E E++ +++ + Q S L E + ++++ K++ S E+Q ++E
Sbjct: 1140 RCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1199
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL 317
V ++ E + +ALK KL+ + +SK K + +L+T+ ++ E L
Sbjct: 1200 EV-----------SKLQSEVQNTKQALK-KLETREVVDLSKYKATKSDLETQISSLNEKL 1247
Query: 318 KNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
N L K E + E+ + AK ++I SA ++ ++ E+ + +E C
Sbjct: 1248 AN--LNRKYEE---------VCEEVLHAKKKEI--SAKDEKELLHFSIEQEIKDQKERCD 1294
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
+ TI L++ I+E ++ +N+ ++L ++ LK + LS
Sbjct: 1295 KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1339
Score = 54.0 bits (124), Expect = 2e-06
Identities = 137/625 (21%), Positives = 254/625 (40%), Gaps = 58/625 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E Q++D K + + +L + +Q N + E R KL N E +
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQ--NEMIVEEFKRDEGKLIEENKRLQKELSMC 598
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK 241
+ + EK + +M + EL K AL + SSL + + K L E
Sbjct: 599 E-MEREKKGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEK---AKKLVEM 653
Query: 242 LTSNELTLAETQQ---RLEMVKGHHALAL--EANESI--RREYKI-ELEALKTKLDEEKQ 293
+E +L+E +Q LE VK A + E +E + R E K EL T+L + Q
Sbjct: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 294 AI---ISKCKVDQENLKTK-HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
+ I K +D + LK + HN +IE + + + E +++ H +I ++ KL
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAII---DDLNRKLLD 770
Query: 350 IEESASEK-LKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTLDLTNNQNS 405
+ + +EK L++ ++ E + S+ + S+ E + E+EI LK + Q S
Sbjct: 771 VTQKYTEKKLEMEKLLLE--NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLS 828
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-- 463
+LK++ + L++E N +K + +E K LN + K +E
Sbjct: 829 ELKKKCGEDQEKIHALTSENTN----LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELL 884
Query: 464 --KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
K KFE + ++ V ++++ + L++ + Q A+ + E ++L+
Sbjct: 885 DVKKKFE---DINQEFV-----KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 936
Query: 522 NTVREC-DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
++R+ D E L N K + + H I L +++Q K Y + + + E
Sbjct: 937 QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL-DTIQECIKVKYAPIVSFE-EC 994
Query: 581 IEDVELLKKESNSQIK-------FLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQA 633
+ +KE Q+ EEV+K + + VL+ ++
Sbjct: 995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1054
Query: 634 ---AADLSRLENE-NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
LSR +E N++ + L +EN + T + +++ K L
Sbjct: 1055 HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1114
Query: 690 EQSQYTPKSPSVLRKSLKVGKENMQ 714
EQ + KS + ++LK ++MQ
Sbjct: 1115 EQVEALKKSLNGTIENLKEELKSMQ 1139
>BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 74.5 bits (175), Expect = 1e-12
Identities = 105/521 (20%), Positives = 221/521 (42%), Gaps = 40/521 (7%)
Query: 108 AQDVEIRNK-DQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
A E+R K +Q + E K +E+ KN AQ+Q++ RQ H E+ +L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--------RQRHATA-LEELSEQLE 1213
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+ + N ++ TD ++++ + ++ E E K + LD +V + ++S +
Sbjct: 1214 QAKRFKANLEKNKQGLE-TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-----ESIRRE--YK 278
+ LQ +L N TL E ++ + A +LE+ E ++ E K
Sbjct: 1273 RLRVELAEKASKLQNEL-DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK---------CEAL 329
+ L + +L+EEK ++ + + ++E K + +L++Q+ K E+L
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK-QVLALQSQLADTKKKVDDDLGTIESL 1390
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E+ +L+ + + +LE+ + A +KL+ + + ++ + Q + LE++
Sbjct: 1391 EEAKKKLLKDAEALSQRLEE-KALAYDKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKK 1449
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
K+ L + ++ +E + + E T+ + + +E +E +E +
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL----EEALEAKEEFERQ 1505
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L +E + K+ ++ L ++ E ++LE+LED++Q AK L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTKEHTRIMEHNVTLIESLQNVE-- 566
E + K ++ DE E +L K L E + + S + +E
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 567 -KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
K+ ++ E ++ L+K +Q+K + E+E+ R
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRK-LQAQMKDYQRELEEAR 1665
Score = 72.5 bits (170), Expect = 5e-12
Identities = 121/625 (19%), Positives = 271/625 (43%), Gaps = 51/625 (8%)
Query: 95 PKNKILPQDELVQAQDVEIRN--KDQTICE--------YNKQIEDYKNEIAQLQEILKEL 144
P ++ Q+E +QA+D E+ + QT E ++Q+ + KN +A+ + EL
Sbjct: 843 PLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 145 ATKFRQSHNNIDFN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+ + + E++ L L + E N + + +K+ A I D+ ++ E
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLE-SRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 203 LEKKCEALDNEVYDKQMELSSL-EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E + L E + ++ + EE++ + D K ++EK + + Q E +
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
LA IR + ++ + L+ +L +E+ K + + E K K + L++Q+
Sbjct: 1022 AKNLA-----KIRNKQEVMISDLEERLKKEE-----KTRQELEKAKRKLDGETTDLQDQI 1071
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ--SIQEHCSQQ 379
+ + + +++L QL KE+E++ L + ++ K ++ E ++Q +QE +
Sbjct: 1072 AELQAQ-IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ + E++ ++L L+ ++L+ L+ + EL T++ +E+ LK L
Sbjct: 1131 KASRNKAEKQKRDLSEELEAL---KTELEDTLDTTA-AQQELRTKR---EQEVAELKKAL 1183
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
E+T N+E + + A++E ++ L + L + +++ ++L +V
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSE---QLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
++L K E++ + + E V + + + L E +++ TL+
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE----LDNVSTLL 1296
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLCEMXXXXX 616
E + + ++ +++++L + ELL++E+ ++ +R+ E+K L E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ----- 1351
Query: 617 XXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVA 676
+ L Q A S+L + ++ SL L ++ E L+ +
Sbjct: 1352 --QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSV 701
+++ DKL+K + Q P +V
Sbjct: 1410 EKALAYDKLEKTKNRLQQEPDDLTV 1434
Score = 63.7 bits (148), Expect = 2e-09
Identities = 116/617 (18%), Positives = 263/617 (42%), Gaps = 49/617 (7%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLR 168
++++ + + E +Q + + I QL+E L+E + ++ N++ ++ S+L
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE-KQVLALQSQLA 1374
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLE 225
+ ++ + K ++ D + LE+K A D K Q E L
Sbjct: 1375 DTKKKVDDDLGTIESLEEAK-KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEPDDLT 1433
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ + + +L++K + LAE + + +A + E+ RE + + +L
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISARYAEERDRAEAEAREKETKALSLA 1489
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+E A+ +K + +++N + + + + S K+ + K E LE+ L + +EM+
Sbjct: 1490 RALEE---ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQQVEEMR 1545
Query: 345 AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN 404
+LE++E+ + + +++ E Q+++ +Q E+ +Q +++ +E K L Q
Sbjct: 1546 TQLEELEDEL-QATEDAKLRLEVNMQAMK---AQFERDLQTRDEQNEEKKRLLI---KQV 1598
Query: 405 SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+L+ EL + + + K ++K L+ + IE +E K ++ +K+
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
+ +RD + + +ES+ +L+ LE ++ L + EL + + +
Sbjct: 1658 QRELEEARASRDEIFAQS---KESEKKLKSLEAEILQL-------QEELASSERARRHAE 1707
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE--KEAYR----ELG 574
+E DE + + N K+AL E R+ L E L+ N+E + +R ++
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA 634
T+ EL + +K N++ + R+ E K L E+ + Q
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 635 ADLSRLENE----NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L + E N+ + +++ R+ ++ + K ++ + +LK+ LE
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887
Query: 691 QSQYTPKSPSVLRKSLK 707
+++ + R+ L+
Sbjct: 1888 EAEEEATRANASRRKLQ 1904
Score = 54.0 bits (124), Expect = 2e-06
Identities = 76/391 (19%), Positives = 161/391 (41%), Gaps = 32/391 (8%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIE--DYKNE------IAQLQEILKELATKFRQ 150
+DEL +D ++R N ++ + ++ D +NE I Q++E+ EL + +Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 151 SHNNIDFN---EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ EID K + +I N + Q K+ A + D + + E
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQAQMKDYQRELEEARASR 1668
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + + + + +L SLE I LQE+L S+E +Q + + +
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEIL-------QLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
++ E K LEA +L+EE + S ++ + + K +++L ++ E+
Sbjct: 1722 SGKSALLDE-KRRLEARIAQLEEELEEEQSNMELLNDRFR-KTTLQVDTLNAELAAERSA 1779
Query: 328 AL--EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
A + QL + +E+KAKL+++E + K K E + ++E Q+ K
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
+ ++ + L Q D ++ + K ++ + ++++K +E E+
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR----MKQLKRQLEEAEEEATR 1895
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
+ KL ++ A + +S ++
Sbjct: 1896 ANASRRKLQRELDDATEANEGLSREVSTLKN 1926
>BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for
IMAGE:5563109) protein.
Length = 1374
Score = 74.5 bits (175), Expect = 1e-12
Identities = 109/457 (23%), Positives = 202/457 (44%), Gaps = 47/457 (10%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ-EKLTSN 245
+++ + +D+ +R+ E E++C+ L E Q + LEE + +S + LQ EK+T+
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 246 E--LTLAETQ-----QRLEMVKGHHAL-----ALEANESIRREYKIELEALKTKLD---- 289
L E Q Q ++ K L N + E L LK K +
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 290 --EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKL 347
EE+ K + + E + K L +Q+ + + + + +L QL KE+E++A L
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ-IAELKMQLAKKEEELQAAL 1089
Query: 348 EQIEESASE------KLKICEIQFEERSQSIQ-EHCSQQ--EKTIQYLEQEIK----ELK 394
++EE A++ K++ E Q E + ++ E S+ EK + L +E++ EL+
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 395 YTLDLTNNQ---NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN 451
TLD T Q S +QE+N LK +E + I+E++ + +E+ +
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN 511
++ +EKA K E + V VL +S+ + +++E Q+Q L +V N
Sbjct: 1210 RVKANLEKA---KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL----QVKFN 1262
Query: 512 ELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR 571
E + L + V + + + +L + + + T+ + + +ES +E +
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK----DFSALESQLQDTQELLQ 1318
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
E K L ++ ++ E NS + L EE E K L
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Score = 67.3 bits (157), Expect = 2e-10
Identities = 95/458 (20%), Positives = 208/458 (45%), Gaps = 29/458 (6%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKN--EIAQLQEILKELATKFRQSHNNI 155
++ ++E Q E + Q I E +Q+E+ ++ + QL+++ E K + I
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQI 981
Query: 156 DFNEIDRKLSKLR--INNTNCHTEHNAVQGTDAEKVSAMI-NDMRSRIIELEKKCEALDN 212
+ + KL+K + + + N + + K A + N + I +LE++ +
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALEANE 271
+ + + LE T +LQ ++ ++ LA+ ++ L+ A + N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 272 SIR--REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCE 327
+++ RE + ++ L+ L+ E+ S+ K +++ K +E+LK ++ +
Sbjct: 1102 ALKKIRELESQISELQEDLESER---ASRNKAEKQ--KRDLGEELEALKTELEDTLDSTA 1156
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESA-SEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
A ++L S+ +EQE+ + +EE A + + +I E++ ++ SQ+++E Q E+T + +
Sbjct: 1157 AQQELRSK---REQEVNILKKTLEEEAKTHEAQIQEMR-QKHSQAVEELAEQLEQT-KRV 1211
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
+ +++ K TL+ N+ +L E+ L K + ++ ++++ EL K
Sbjct: 1212 KANLEKAKQTLE---NERGELANEVKVLLQGKGDSEHKR----KKVEAQLQELQVKFNEG 1264
Query: 447 ENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAK 506
E + +L V K E + LS + LT +S+L+ ++ +Q K
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 507 EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
L +L ++ N+ + +E +EA N+ K A L
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Score = 66.5 bits (155), Expect = 3e-10
Identities = 70/317 (22%), Positives = 144/317 (45%), Gaps = 17/317 (5%)
Query: 300 KVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESASE 356
KV ++ L ++ + +E+L++Q++ EK + EQL ++ L + +E++A+L ++ E
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 357 KLKICEIQFEE---RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
E + EE R Q +Q + ++ IQ LE++++E + + + +L
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L+ + L + +E K L+D + E T N E+ K + K KNK E ++
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK----SKSLAKLKNKHEAMITD 1031
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ + + +E + +LE L+ L+ ++ K L ++ +E + A
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQAA 1088
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKES 591
L + + A +I E + E +++E E + + K +L E++E LK E
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 592 NSQI--KFLREEVEKKR 606
+ ++E+ KR
Sbjct: 1149 EDTLDSTAAQQELRSKR 1165
Score = 37.9 bits (84), Expect = 0.13
Identities = 44/213 (20%), Positives = 94/213 (44%), Gaps = 9/213 (4%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA 145
++K L + Q EL ++ E+ +T+ E K E E+ Q + ++ELA
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 146 TKFRQSHN-NIDFNEIDRKLSKLR---INNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q+ + + + L R N + +KV A + +++ +
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E E+ L ++V Q+EL ++ +++ DS L + ++ E L +TQ+ L+ +
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ-EEN 1321
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQA 294
L+L ++ + E + + +L+EE++A
Sbjct: 1322 RQKLSLSTK---LKQVEDEKNSFREQLEEEEEA 1351
>AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20-7
protein.
Length = 623
Score = 74.5 bits (175), Expect = 1e-12
Identities = 107/439 (24%), Positives = 198/439 (45%), Gaps = 35/439 (7%)
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQME-LSSLEEVITVRDSLCKDLQEKLTSNE 246
K+ + D ++ I +LE+ + E + E L EE I S K + + E
Sbjct: 6 KLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ--GEE 63
Query: 247 LT-LAETQQRLEMVKGHHALAL-EANESIRREYKIEL-EALKTKLDEEKQAIISKCKVDQ 303
L E +R + AL+ + E RR+ K E+ E +KT EK + + + Q
Sbjct: 64 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTI---EKTSEEERISLQQ 120
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHS-QLIIKEQEMKAKLEQIEESASEKLKICE 362
E + K ++ +K +E+ L++LH +L KEQE+ KL+ E E++K+
Sbjct: 121 ELSRVKQEV-VDVMKKSS-EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVA- 177
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS--DLKQELNNLKNCKDE 420
E+SQS SQ+++ + L E EL+ LT ++N DL+QE + E
Sbjct: 178 ---LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILE 234
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE-TSLSVTRDIVH 479
L + ++E K +L ++ E EKNK N+ + + EK+K E SL +D +
Sbjct: 235 LESSLEKSLQENKNQSKDL---AVHLEAEKNKHNMEITVMV-EKHKTELESLKHQQDALW 290
Query: 480 VLTLRL--RESDSELEQL----EDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
L++ ++ +E+E+L E + + L KE++ N T+ + D +
Sbjct: 291 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN--EKTLEKLDVKQTE 348
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNS 593
L ++ + + K ++ E L + +++E ++ KN + V+ + KE
Sbjct: 349 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 408
Query: 594 QI----KFLREEVEKKRVL 608
I K L++++ + +L
Sbjct: 409 SIQRTEKALKDQINQLELL 427
Score = 62.1 bits (144), Expect = 7e-09
Identities = 108/506 (21%), Positives = 225/506 (44%), Gaps = 73/506 (14%)
Query: 74 TPKAFKITKAPNSSIKKTL--TCPKNKILPQDELVQAQ----DVEIRNKDQTICEYNKQI 127
T +A + KA KT+ T + +I Q EL + + DV ++ ++ I + K
Sbjct: 89 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 148
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
E K + QE+ K+L T+ R+ + + L+I+ E A++ + +
Sbjct: 149 E--KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 206
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS-SLEEVITVRDSLCKDLQ-EKLTSN 245
K A++ + +++ +L+++ E + + + L SL+E L L+ EK N
Sbjct: 207 K-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 265
Query: 246 -ELTLAETQQRLEMVKGHH---ALALEANESIRREYKIELEALKTKLDEEKQA------I 295
E+T+ + + E+ H AL E + ++++Y+ E+E L+ K ++EK+ I
Sbjct: 266 MEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 325
Query: 296 ISKCKVDQENLKTKHNASI-----ESLKNQMLKEKCEALEQLHSQL-IIKEQ------EM 343
I + +++ N KT + ESL ++ L E +A +L +L ++K+Q E+
Sbjct: 326 IFQAHIEEMNEKTLEKLDVKQTELESLSSE-LSEVLKARHKLEEELSVLKDQTDKMKQEL 384
Query: 344 KAKLEQ----------------------IEESASEKLKICEIQFEERSQSIQE---HCSQ 378
+AK+++ E++ +++ E+ +ER + ++E H
Sbjct: 385 EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVEN 444
Query: 379 QEKTIQYLEQEIKELKYTLDL-------TNNQNSDLKQELNNLKNCKDELSTEKFNFIEE 431
E I+ E E+++ LD+ T+ Q +++L L+ +L TE+ ++
Sbjct: 445 LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ 504
Query: 432 IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
+ + E +K + E + +K+ + EK E V + + V +L + + E
Sbjct: 505 VAEV--EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-KSLTQVYESKLEDGNKE 561
Query: 492 LEQ----LEDQVQMLTSAKEVLENEL 513
EQ L ++ M+ +E + E+
Sbjct: 562 QEQTKQILVEKENMILQMREGQKKEI 587
Score = 61.3 bits (142), Expect = 1e-08
Identities = 87/389 (22%), Positives = 163/389 (41%), Gaps = 33/389 (8%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
Q+ Q++D+ + K++ E +E +K E+ L+ L T+ Q +
Sbjct: 244 QENKNQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESLKHQQDALWTEKLQ----VLKQ 299
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL----EKKCEALDNEV 214
+ ++ KLR C E + A I +M + +E + + E+L +E+
Sbjct: 300 QYQTEMEKLR---EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 356
Query: 215 YDKQMELSSLEEVITV-RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI 273
+ LEE ++V +D K QE + QQ+++ + H ++++ E
Sbjct: 357 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 416
Query: 274 RREYKIELEALKTKLD---EEKQAIISKCKVD---------QENLKTKHNASIESLKNQM 321
++ +LE L + D +E QA + + D Q + K S +S ++
Sbjct: 417 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQ 476
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
K E L QL +L+ E E +Q+ E ++K +C + + +Q+ Q EK
Sbjct: 477 TKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC-TELDAHKIQVQDLMQQLEK 535
Query: 382 TIQYLEQEIKEL----KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
+EQ++K L + L+ N + KQ L +N ++ + I EI T K
Sbjct: 536 QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI-EILTQKL 594
Query: 438 ELIEKTINYENEKNKLNLAVEKAIKEKNK 466
E +I+ NE+ + +K K+K K
Sbjct: 595 SAKEDSIHILNEEYETKFKKKKKKKKKKK 623
>M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy chain
protein.
Length = 1337
Score = 74.1 bits (174), Expect = 2e-12
Identities = 89/421 (21%), Positives = 191/421 (45%), Gaps = 36/421 (8%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ-EKLTSN 245
+++ + +D+ +R+ E E++C+ L E Q + LEE + +S + LQ EK+T
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT-- 968
Query: 246 ELTLAETQQRLEMVKGHHALALEANESIRREYKI---ELEALKTKLDEEKQAIISKCKVD 302
T+ +L+ ++ + + N + +E K+ + T L EE++ S K
Sbjct: 969 ------TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-- 1020
Query: 303 QENLKTKHNASIESLKNQMLKE--KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
LK KH A I L+ ++ +E + + LE+ +L ++ ++ +++ +E
Sbjct: 1021 ---LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE---- 1073
Query: 361 CEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDE 420
++Q ++ + +Q ++ E+ +K+++ +Q S+L+++L + + +++
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNK 1129
Query: 421 LSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
+K + EE++ LK EL E T++ + +L E+ + K + T + +
Sbjct: 1130 AEKQKRDLGEELEALKTEL-EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-AQI 1187
Query: 481 LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE-CDEYKEALVNILK 539
+R + S + +E+L +Q++ K LE K TL N E +E K L
Sbjct: 1188 QEMRQKHSQA-VEELAEQLEQTKRVKANLEKA----KQTLENERGELANEVKVLLQGKGD 1242
Query: 540 SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLR 599
S+ K ++ E V E + V E ++ ++ EL LL + + K +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEG-ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 600 E 600
+
Sbjct: 1302 D 1302
Score = 66.5 bits (155), Expect = 3e-10
Identities = 70/317 (22%), Positives = 144/317 (45%), Gaps = 17/317 (5%)
Query: 300 KVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQ--LIIKEQEMKAKLEQIEESASE 356
KV ++ L ++ + +E+L++Q++ EK + EQL ++ L + +E++A+L ++ E
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 357 KLKICEIQFEE---RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN 413
E + EE R Q +Q + ++ IQ LE++++E + + + +L
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
L+ + L + +E K L+D + E T N E+ K + K KNK E ++
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK----SKSLAKLKNKHEAMITD 1031
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
+ + + +E + +LE L+ L+ ++ K L ++ +E + A
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQAA 1088
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE--AYRELGTIKNELIEDVELLKKES 591
L + + A +I E + E +++E E + + K +L E++E LK E
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 592 NSQI--KFLREEVEKKR 606
+ ++E+ KR
Sbjct: 1149 EDTLDSTAAQQELRSKR 1165
Score = 61.7 bits (143), Expect = 9e-09
Identities = 89/426 (20%), Positives = 194/426 (45%), Gaps = 36/426 (8%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKN--EIAQLQEILKELATKFRQSHNNI 155
++ ++E Q E + Q I E +Q+E+ ++ + QL+++ E K + I
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQI 981
Query: 156 DFNEIDRKLSKLR--INNTNCHTEHNAVQGTDAEKVSAMI-NDMRSRIIELEKKCEALDN 212
+ + KL+K + + + N + + K A + N + I +LE++ +
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALEANE 271
+ + + LE T +LQ ++ ++ LA+ ++ L+ A + N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 272 SIR--REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM--LKEKCE 327
+++ RE + ++ L+ L+ E+ S+ K +++ K +E+LK ++ +
Sbjct: 1102 ALKKIRELESQISELQEDLESER---ASRNKAEKQ--KRDLGEELEALKTELEDTLDSTA 1156
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESA-SEKLKICEIQFEERSQSIQEHCSQQEKT---- 382
A ++L S+ +EQE+ + +EE A + + +I E++ ++ SQ+++E Q E+T
Sbjct: 1157 AQQELRSK---REQEVNILKKTLEEEAKTHEAQIQEMR-QKHSQAVEELAEQLEQTKRVK 1212
Query: 383 ------IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-L 435
Q LE E EL + + D + + ++ EL KFN E ++T L
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV-KFNEGERVRTEL 1271
Query: 436 KDELIEKTINYENEKNKLNLAVEKAIKEKNKF---ETSLSVTRDIVHVLTLRLRESDSEL 492
D++ + + +N L+ + K+ K F E+ L T++++ + ++L
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 493 EQLEDQ 498
+Q+ED+
Sbjct: 1332 KQVEDE 1337
Score = 34.3 bits (75), Expect = 1.5
Identities = 37/176 (21%), Positives = 76/176 (43%), Gaps = 5/176 (2%)
Query: 87 SIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA 145
++K L + Q EL ++ E+ +T+ E K E E+ Q + ++ELA
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 146 TKFRQSHN-NIDFNEIDRKLSKLR---INNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
+ Q+ + + + L R N + +KV A + +++ +
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE 257
E E+ L ++V Q+EL ++ +++ DS L + ++ E L +TQ+ L+
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
>M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein.
Length = 1976
Score = 74.1 bits (174), Expect = 2e-12
Identities = 115/614 (18%), Positives = 265/614 (43%), Gaps = 44/614 (7%)
Query: 95 PKNKILPQDELVQAQDVEIRN--KDQTICE--------YNKQIEDYKNEIAQLQEILKEL 144
P ++ Q+E +QA+D E+ + QT E ++Q+ + KN +A+ + EL
Sbjct: 843 PLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 145 ATKFRQSHNNIDFN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+ + + E++ L L + E N + + +K+ A I D+ ++ E
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLE-SRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 203 LEKKCEALDNEVYDKQMELSSL-EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E + L E + ++ + EE++ + D K ++EK + + Q E +
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
LA IR + ++ + L+ +L +E+ K + + E K K + L++Q+
Sbjct: 1022 AKNLA-----KIRNKQEVMISDLEERLKKEE-----KTRQELEKAKRKLDGETTDLQDQI 1071
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ--SIQEHCSQQ 379
+ + + +++L QL KE+E++ L + ++ K ++ E ++Q +QE +
Sbjct: 1072 AELQAQ-IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ + E++ ++L L+ ++L+ L+ + EL T++ +E+ LK L
Sbjct: 1131 KASRNKAEKQKRDLSEELEAL---KTELEDTLDTTA-AQQELRTKR---EQEVAELKKAL 1183
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
E+T N+E + + A++E ++ L + L + +++ ++L +V
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSE---QLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
++L K E++ + + E V + + + L E +++ TL+
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE----LDNVSTLL 1296
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLCEMXXXXX 616
E + + ++ +++++L + ELL++E+ ++ +R+ E+K L E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 617 XXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVA 676
L +Q A +++++ L+ + L Q EE +
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 677 KQSSIIDKLKKDLE 690
K ++L+++L+
Sbjct: 1417 KLEKTKNRLQQELD 1430
Score = 74.1 bits (174), Expect = 2e-12
Identities = 105/521 (20%), Positives = 221/521 (42%), Gaps = 40/521 (7%)
Query: 108 AQDVEIRNK-DQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
A E+R K +Q + E K +E+ KN AQ+Q++ RQ H E+ +L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--------RQRHATA-LEELSEQLE 1213
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+ + N ++ TD ++++ + ++ E E K + LD +V + ++S +
Sbjct: 1214 QAKRFKANLEKNKQGLE-TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-----ESIRRE--YK 278
+ LQ +L N TL E ++ + A +LE+ E ++ E K
Sbjct: 1273 RLRVELAEKASKLQNEL-DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK---------CEAL 329
+ L + +L+EEK ++ + + ++E K + +L++Q+ K E+L
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK-QVLALQSQLADTKKKVDDDLGTIESL 1390
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E+ +L+ + + +LE+ + A +KL+ + + ++ + Q + LE++
Sbjct: 1391 EEAKKKLLKDAEALSQRLEE-KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
K+ L + ++ +E + + E T+ + + +E +E +E +
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL----EEALEAKEEFERQ 1505
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L +E + K+ ++ L ++ E ++LE+LED++Q AK L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTKEHTRIMEHNVTLIESLQNVE-- 566
E + K ++ DE E +L K L E + + S + +E
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 567 -KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
K+ ++ E ++ L+K +Q+K + E+E+ R
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRK-LQAQMKDYQRELEEAR 1665
Score = 66.5 bits (155), Expect = 3e-10
Identities = 117/617 (18%), Positives = 264/617 (42%), Gaps = 49/617 (7%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLR 168
++++ + + E +Q + + I QL+E L+E + ++ N++ ++ S+L
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE-KQVLALQSQLA 1374
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLE 225
+ ++ + K ++ D + LE+K A D K Q EL L
Sbjct: 1375 DTKKKVDDDLGTIESLEEAK-KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ + + +L++K + LAE + + +A + E+ RE + + +L
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISARYAEERDRAEAEAREKETKALSLA 1489
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+E A+ +K + +++N + + + + S K+ + K E LE+ L + +EM+
Sbjct: 1490 RALEE---ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQQVEEMR 1545
Query: 345 AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN 404
+LE++E+ + + +++ E Q+++ +Q E+ +Q +++ +E K L Q
Sbjct: 1546 TQLEELEDEL-QATEDAKLRLEVNMQAMK---AQFERDLQTRDEQNEEKKRLLI---KQV 1598
Query: 405 SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+L+ EL + + + K ++K L+ + IE +E K ++ +K+
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
+ +RD + + +ES+ +L+ LE ++ L + EL + + +
Sbjct: 1658 QRELEEARASRDEIFAQS---KESEKKLKSLEAEILQL-------QEELASSERARRHAE 1707
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE--KEAYR----ELG 574
+E DE + + N K+AL E R+ L E L+ N+E + +R ++
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA 634
T+ EL + +K N++ + R+ E K L E+ + Q
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 635 ADLSRLENE----NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L + E N+ + +++ R+ ++ + K ++ + +LK+ LE
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887
Query: 691 QSQYTPKSPSVLRKSLK 707
+++ + R+ L+
Sbjct: 1888 EAEEEATRANASRRKLQ 1904
Score = 54.0 bits (124), Expect = 2e-06
Identities = 76/391 (19%), Positives = 161/391 (41%), Gaps = 32/391 (8%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIE--DYKNE------IAQLQEILKELATKFRQ 150
+DEL +D ++R N ++ + ++ D +NE I Q++E+ EL + +Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 151 SHNNIDFN---EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ EID K + +I N + Q K+ A + D + + E
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQAQMKDYQRELEEARASR 1668
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + + + + +L SLE I LQE+L S+E +Q + + +
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEIL-------QLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
++ E K LEA +L+EE + S ++ + + K +++L ++ E+
Sbjct: 1722 SGKSALLDE-KRRLEARIAQLEEELEEEQSNMELLNDRFR-KTTLQVDTLNAELAAERSA 1779
Query: 328 AL--EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
A + QL + +E+KAKL+++E + K K E + ++E Q+ K
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
+ ++ + L Q D ++ + K ++ + ++++K +E E+
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR----MKQLKRQLEEAEEEATR 1895
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
+ KL ++ A + +S ++
Sbjct: 1896 ANASRRKLQRELDDATEANEGLSREVSTLKN 1926
>BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 74.1 bits (174), Expect = 2e-12
Identities = 115/614 (18%), Positives = 265/614 (43%), Gaps = 44/614 (7%)
Query: 95 PKNKILPQDELVQAQDVEIRN--KDQTICE--------YNKQIEDYKNEIAQLQEILKEL 144
P ++ Q+E +QA+D E+ + QT E ++Q+ + KN +A+ + EL
Sbjct: 843 PLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 145 ATKFRQSHNNIDFN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+ + + E++ L L + E N + + +K+ A I D+ ++ E
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLE-SRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 203 LEKKCEALDNEVYDKQMELSSL-EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E + L E + ++ + EE++ + D K ++EK + + Q E +
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
LA IR + ++ + L+ +L +E+ K + + E K K + L++Q+
Sbjct: 1022 AKNLA-----KIRNKQEVMISDLEERLKKEE-----KTRQELEKAKRKLDGETTDLQDQI 1071
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ--SIQEHCSQQ 379
+ + + +++L QL KE+E++ L + ++ K ++ E ++Q +QE +
Sbjct: 1072 AELQAQ-IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ + E++ ++L L+ ++L+ L+ + EL T++ +E+ LK L
Sbjct: 1131 KASRNKAEKQKRDLSEELEAL---KTELEDTLDTTA-AQQELRTKR---EQEVAELKKAL 1183
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
E+T N+E + + A++E ++ L + L + +++ ++L +V
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSE---QLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
++L K E++ + + E V + + + L E +++ TL+
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE----LDNVSTLL 1296
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLCEMXXXXX 616
E + + ++ +++++L + ELL++E+ ++ +R+ E+K L E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 617 XXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVA 676
L +Q A +++++ L+ + L Q EE +
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 677 KQSSIIDKLKKDLE 690
K ++L+++L+
Sbjct: 1417 KLEKTKNRLQQELD 1430
Score = 74.1 bits (174), Expect = 2e-12
Identities = 105/521 (20%), Positives = 221/521 (42%), Gaps = 40/521 (7%)
Query: 108 AQDVEIRNK-DQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
A E+R K +Q + E K +E+ KN AQ+Q++ RQ H E+ +L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--------RQRHATA-LEELSEQLE 1213
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+ + N ++ TD ++++ + ++ E E K + LD +V + ++S +
Sbjct: 1214 QAKRFKANLEKNKQGLE-TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-----ESIRRE--YK 278
+ LQ +L N TL E ++ + A +LE+ E ++ E K
Sbjct: 1273 RLRVELAEKASKLQNEL-DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK---------CEAL 329
+ L + +L+EEK ++ + + ++E K + +L++Q+ K E+L
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK-QVLALQSQLADTKKKVDDDLGTIESL 1390
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E+ +L+ + + +LE+ + A +KL+ + + ++ + Q + LE++
Sbjct: 1391 EEAKKKLLKDAEALSQRLEE-KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
K+ L + ++ +E + + E T+ + + +E +E +E +
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL----EEALEAKEEFERQ 1505
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L +E + K+ ++ L ++ E ++LE+LED++Q AK L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTKEHTRIMEHNVTLIESLQNVE-- 566
E + K ++ DE E +L K L E + + S + +E
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 567 -KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
K+ ++ E ++ L+K +Q+K + E+E+ R
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRK-LQAQMKDYQRELEEAR 1665
Score = 66.5 bits (155), Expect = 3e-10
Identities = 117/617 (18%), Positives = 264/617 (42%), Gaps = 49/617 (7%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLR 168
++++ + + E +Q + + I QL+E L+E + ++ N++ ++ S+L
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE-KQVLALQSQLA 1374
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLE 225
+ ++ + K ++ D + LE+K A D K Q EL L
Sbjct: 1375 DTKKKVDDDLGTIESLEEAK-KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ + + +L++K + LAE + + +A + E+ RE + + +L
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISARYAEERDRAEAEAREKETKALSLA 1489
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+E A+ +K + +++N + + + + S K+ + K E LE+ L + +EM+
Sbjct: 1490 RALEE---ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQQVEEMR 1545
Query: 345 AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN 404
+LE++E+ + + +++ E Q+++ +Q E+ +Q +++ +E K L Q
Sbjct: 1546 TQLEELEDEL-QATEDAKLRLEVNMQAMK---AQFERDLQTRDEQNEEKKRLLI---KQV 1598
Query: 405 SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+L+ EL + + + K ++K L+ + IE +E K ++ +K+
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
+ +RD + + +ES+ +L+ LE ++ L + EL + + +
Sbjct: 1658 QRELEEARASRDEIFAQS---KESEKKLKSLEAEILQL-------QEELASSERARRHAE 1707
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE--KEAYR----ELG 574
+E DE + + N K+AL E R+ L E L+ N+E + +R ++
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA 634
T+ EL + +K N++ + R+ E K L E+ + Q
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 635 ADLSRLENE----NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L + E N+ + +++ R+ ++ + K ++ + +LK+ LE
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887
Query: 691 QSQYTPKSPSVLRKSLK 707
+++ + R+ L+
Sbjct: 1888 EAEEEATRANASRRKLQ 1904
Score = 54.0 bits (124), Expect = 2e-06
Identities = 76/391 (19%), Positives = 161/391 (41%), Gaps = 32/391 (8%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIE--DYKNE------IAQLQEILKELATKFRQ 150
+DEL +D ++R N ++ + ++ D +NE I Q++E+ EL + +Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 151 SHNNIDFN---EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ EID K + +I N + Q K+ A + D + + E
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQAQMKDYQRELEEARASR 1668
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + + + + +L SLE I LQE+L S+E +Q + + +
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEIL-------QLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
++ E K LEA +L+EE + S ++ + + K +++L ++ E+
Sbjct: 1722 SGKSALLDE-KRRLEARIAQLEEELEEEQSNMELLNDRFR-KTTLQVDTLNAELAAERSA 1779
Query: 328 AL--EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
A + QL + +E+KAKL+++E + K K E + ++E Q+ K
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
+ ++ + L Q D ++ + K ++ + ++++K +E E+
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR----MKQLKRQLEEAEEEATR 1895
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
+ KL ++ A + +S ++
Sbjct: 1896 ANASRRKLQRELDDATEANEGLSREVSTLKN 1926
>AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein
protein.
Length = 2018
Score = 74.1 bits (174), Expect = 2e-12
Identities = 115/614 (18%), Positives = 265/614 (43%), Gaps = 44/614 (7%)
Query: 95 PKNKILPQDELVQAQDVEIRN--KDQTICE--------YNKQIEDYKNEIAQLQEILKEL 144
P ++ Q+E +QA+D E+ + QT E ++Q+ + KN +A+ + EL
Sbjct: 885 PLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 944
Query: 145 ATKFRQSHNNIDFN--EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIE 202
+ + + E++ L L + E N + + +K+ A I D+ ++ E
Sbjct: 945 FAEAEEMRARLAAKKQELEEILHDLE-SRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 1003
Query: 203 LEKKCEALDNEVYDKQMELSSL-EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E + L E + ++ + EE++ + D K ++EK + + Q E +
Sbjct: 1004 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1063
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
LA IR + ++ + L+ +L +E+ K + + E K K + L++Q+
Sbjct: 1064 AKNLA-----KIRNKQEVMISDLEERLKKEE-----KTRQELEKAKRKLDGETTDLQDQI 1113
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ--SIQEHCSQQ 379
+ + + +++L QL KE+E++ L + ++ K ++ E ++Q +QE +
Sbjct: 1114 AELQAQ-IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1172
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
+ + E++ ++L L+ ++L+ L+ + EL T++ +E+ LK L
Sbjct: 1173 KASRNKAEKQKRDLSEELEAL---KTELEDTLDTTA-AQQELRTKR---EQEVAELKKAL 1225
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
E+T N+E + + A++E ++ L + L + +++ ++L +V
Sbjct: 1226 EEETKNHEAQIQDMRQRHATALEELSE---QLEQAKRFKANLEKNKQGLETDNKELACEV 1282
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
++L K E++ + + E V + + + L E +++ TL+
Sbjct: 1283 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE----LDNVSTLL 1338
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVLCEMXXXXX 616
E + + ++ +++++L + ELL++E+ ++ +R+ E+K L E
Sbjct: 1339 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1398
Query: 617 XXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVA 676
L +Q A +++++ L+ + L Q EE +
Sbjct: 1399 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1458
Query: 677 KQSSIIDKLKKDLE 690
K ++L+++L+
Sbjct: 1459 KLEKTKNRLQQELD 1472
Score = 74.1 bits (174), Expect = 2e-12
Identities = 105/521 (20%), Positives = 221/521 (42%), Gaps = 40/521 (7%)
Query: 108 AQDVEIRNK-DQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
A E+R K +Q + E K +E+ KN AQ+Q++ RQ H E+ +L
Sbjct: 1205 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--------RQRHATA-LEELSEQLE 1255
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
+ + N ++ TD ++++ + ++ E E K + LD +V + ++S +
Sbjct: 1256 QAKRFKANLEKNKQGLE-TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1314
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-----ESIRRE--YK 278
+ LQ +L N TL E ++ + A +LE+ E ++ E K
Sbjct: 1315 RLRVELAEKASKLQNEL-DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1373
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK---------CEAL 329
+ L + +L+EEK ++ + + ++E K + +L++Q+ K E+L
Sbjct: 1374 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK-QVLALQSQLADTKKKVDDDLGTIESL 1432
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E+ +L+ + + +LE+ + A +KL+ + + ++ + Q + LE++
Sbjct: 1433 EEAKKKLLKDAEALSQRLEE-KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1491
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
K+ L + ++ +E + + E T+ + + +E +E +E +
Sbjct: 1492 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL----EEALEAKEEFERQ 1547
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L +E + K+ ++ L ++ E ++LE+LED++Q AK L
Sbjct: 1548 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1607
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNIL-KSKAALTKEHTRIMEHNVTLIESLQNVE-- 566
E + K ++ DE E +L K L E + + S + +E
Sbjct: 1608 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1667
Query: 567 -KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
K+ ++ E ++ L+K +Q+K + E+E+ R
Sbjct: 1668 LKDLEAQIEAANKARDEVIKQLRK-LQAQMKDYQRELEEAR 1707
Score = 66.5 bits (155), Expect = 3e-10
Identities = 117/617 (18%), Positives = 264/617 (42%), Gaps = 49/617 (7%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATKFRQSHNNIDFNEIDRKLSKLR 168
++++ + + E +Q + + I QL+E L+E + ++ N++ ++ S+L
Sbjct: 1358 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE-KQVLALQSQLA 1416
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK---QMELSSLE 225
+ ++ + K ++ D + LE+K A D K Q EL L
Sbjct: 1417 DTKKKVDDDLGTIESLEEAK-KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1475
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ + + +L++K + LAE + + +A + E+ RE + + +L
Sbjct: 1476 VDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISARYAEERDRAEAEAREKETKALSLA 1531
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNAS-IESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+E A+ +K + +++N + + + + S K+ + K E LE+ L + +EM+
Sbjct: 1532 RALEE---ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQQVEEMR 1587
Query: 345 AKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQN 404
+LE++E+ + + +++ E Q+++ +Q E+ +Q +++ +E K L Q
Sbjct: 1588 TQLEELEDEL-QATEDAKLRLEVNMQAMK---AQFERDLQTRDEQNEEKKRLLI---KQV 1640
Query: 405 SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+L+ EL + + + K ++K L+ + IE +E K ++ +K+
Sbjct: 1641 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIKQLRKLQAQMKDY 1699
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
+ +RD + + +ES+ +L+ LE ++ L + EL + + +
Sbjct: 1700 QRELEEARASRDEIFAQS---KESEKKLKSLEAEILQL-------QEELASSERARRHAE 1749
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE--KEAYR----ELG 574
+E DE + + N K+AL E R+ L E L+ N+E + +R ++
Sbjct: 1750 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1809
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA 634
T+ EL + +K N++ + R+ E K L E+ + Q
Sbjct: 1810 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1869
Query: 635 ADLSRLENE----NERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L + E N+ + +++ R+ ++ + K ++ + +LK+ LE
Sbjct: 1870 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1929
Query: 691 QSQYTPKSPSVLRKSLK 707
+++ + R+ L+
Sbjct: 1930 EAEEEATRANASRRKLQ 1946
Score = 54.0 bits (124), Expect = 2e-06
Identities = 76/391 (19%), Positives = 161/391 (41%), Gaps = 32/391 (8%)
Query: 102 QDELVQAQDVEIR---NKDQTICEYNKQIE--DYKNE------IAQLQEILKELATKFRQ 150
+DEL +D ++R N ++ + ++ D +NE I Q++E+ EL + +Q
Sbjct: 1594 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1653
Query: 151 SHNNIDFN---EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ EID K + +I N + Q K+ A + D + + E
Sbjct: 1654 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQAQMKDYQRELEEARASR 1710
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + + + + +L SLE I LQE+L S+E +Q + + +
Sbjct: 1711 DEIFAQSKESEKKLKSLEAEIL-------QLQEELASSERARRHAEQERDELADEITNSA 1763
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
++ E K LEA +L+EE + S ++ + + K +++L ++ E+
Sbjct: 1764 SGKSALLDE-KRRLEARIAQLEEELEEEQSNMELLNDRFR-KTTLQVDTLNAELAAERSA 1821
Query: 328 AL--EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
A + QL + +E+KAKL+++E + K K E + ++E Q+ K
Sbjct: 1822 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1881
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
+ ++ + L Q D ++ + K ++ + ++++K +E E+
Sbjct: 1882 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR----MKQLKRQLEEAEEEATR 1937
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
+ KL ++ A + +S ++
Sbjct: 1938 ANASRRKLQRELDDATEANEGLSREVSTLKN 1968
>Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein.
Length = 1937
Score = 73.7 bits (173), Expect = 2e-12
Identities = 125/625 (20%), Positives = 258/625 (41%), Gaps = 52/625 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S +KK + + + ++ A + +++N + + ++ I E LQE ++
Sbjct: 951 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL 1010
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIN-DMR---SRII 201
+ + ++ + + ++++ E D E+ + D++ +
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
++E + LD ++ K+ E+S+L I ++ LQ+K+ + + E + +E +
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERA 1130
Query: 262 HHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKHNA 312
A A + + RE + E L + +L+++++A K + D E +H A
Sbjct: 1131 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEA 1190
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
+ +L+ K+ +++ +L Q I Q +K KLE+ E+S +LK+ +++I
Sbjct: 1191 MVAALR----KKHADSMAELGEQ-IDNLQRVKQKLEK-EKS---ELKMETDDLSSNAEAI 1241
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEI 432
+ EK + LE ++ ELK + +DL + L+ E S + ++E
Sbjct: 1242 SKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ----LDEK 1297
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
L +L + +L +E+ K KN +L +R H L + + E
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSR---HDCDLLREQYEEEQ 1354
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
E + + L+ A + T Y+ E +E K+ L L+ +EH +
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE----AEEHVEAV 1410
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL-REEVEKKRVLCEM 611
++EK R ++NE +ED+ L + SN+ L +++ +VL E
Sbjct: 1411 N------AKCASLEKTKQR----LQNE-VEDLMLDVERSNAACAALDKKQRNFDKVLSEW 1459
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
S+ + +L +++N Y +L E L+QE +L
Sbjct: 1460 -KQKYEETQAELEASQKESRSLSTELFKVKNV---YEESLDQLETLRRENKNLQQEISDL 1515
Query: 672 TMTVA---KQSSIIDKLKKDLEQSQ 693
T +A KQ ++K+KK +EQ +
Sbjct: 1516 TEQIAEGGKQIHELEKIKKQVEQEK 1540
Score = 67.3 bits (157), Expect = 2e-10
Identities = 105/511 (20%), Positives = 219/511 (42%), Gaps = 43/511 (8%)
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE-MVKG 261
++++ + +E+ + + LEE + DLQ ++ S +LA+ ++R E ++K
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 262 HHALALEANESIRR-----EYKIELEALKTKLDEEKQAI---ISKCKVDQENLKTKHNAS 313
L + E R E EL A K KL++E + I ++ ++ + +A+
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974
Query: 314 IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ-IEESASEKLKI-----CEIQFEE 367
+KN L E+ L++ ++L +++ ++ +Q +++ +E+ K+ + + E+
Sbjct: 975 ENKVKN--LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQ 1032
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ ++ Q++K LE+ ++L+ L L D++ N+ + ++L ++F
Sbjct: 1033 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME---NDKQQLDEKLEKKEFE 1089
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
I ++DE + I + + +L +E+ +E S + L+ L E
Sbjct: 1090 ISNLISKIEDEQAVE-IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
LE+ TSA+ L + L + E EA+V AAL K+
Sbjct: 1149 ISERLEEAGG----ATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV------AALRKK 1198
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
H M I++LQ V+++ +E K+EL + + L + + I + +EK
Sbjct: 1199 HADSMAELGEQIDNLQRVKQKLEKE----KSELKMETDDLSSNAEA-ISKAKGNLEK--- 1250
Query: 608 LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQE 667
+C + L+ A +RL+ E Y +LV +LS +Q
Sbjct: 1251 MCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQA 1310
Query: 668 N----EELTMTVAKQSSIIDKLKKDLEQSQY 694
+ EEL + +++ + L L+ S++
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRH 1341
Score = 66.1 bits (154), Expect = 4e-10
Identities = 82/423 (19%), Positives = 183/423 (43%), Gaps = 21/423 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + + K + +K + ++ L+ K ++ + L+ + EA E
Sbjct: 847 ETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A E+ +I + + + +++ CS+ +K I LE +
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +E+ L +LS EK E + D+L + E++
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE----EDKV 1020
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N L A K ++ + E SL + + L R+ + +L+ ++ + + K+ L+
Sbjct: 1021 NILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLD 1080
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+L + ++N + + ++ + + + K KE +E IE+ + +A
Sbjct: 1081 EKLEKKEFEISNLISKIEDEQAVEIQLQKK----IKELQARIEELGEEIEAERASRAKAE 1136
Query: 571 RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
++ + EL E E L++ + + E+ KKR E ++
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGA--TSAQVELNKKRE-AEFQKLRRDLEEATLQHEAMVA 1193
Query: 631 AQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM---TVAKQSSIIDKLKK 687
A + E+ L E S L+ E ++L+ ++K ++K+ +
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 688 DLE 690
LE
Sbjct: 1254 SLE 1256
Score = 53.6 bits (123), Expect = 2e-06
Identities = 103/526 (19%), Positives = 214/526 (40%), Gaps = 45/526 (8%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T ++ED ++ + L K R D+
Sbjct: 1404 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN---------FDK 1454
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
LS+ + E A Q ++ +S + +++ E + E L E + Q E+S
Sbjct: 1455 VLSEWKQKYEETQAELEASQ-KESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEIS 1513
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E I +L++ E E Q LE + +LE E ++EL
Sbjct: 1514 DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA----SLEHEEGKILRIQLELN 1569
Query: 283 ALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM---LKEKCEALEQLHSQLIIK 339
+K+++D + I++ + + LK H +E++++ + ++ + +AL ++ ++
Sbjct: 1570 QVKSEVDRK----IAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL-RVKKKMEGD 1624
Query: 340 EQEMKAKLEQIEESASEKLK--------ICEIQFE-----ERSQSIQEHCSQQEKTIQYL 386
EM+ +L A+E L+ + E Q + ++E + E+ L
Sbjct: 1625 LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLL 1684
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
+ EI+EL TL+ T +QEL + L T+ + I K L++++ +
Sbjct: 1685 QAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV 1744
Query: 447 E---NEKNKLNLAVEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQ 500
E E +KAI + L +D H+ ++ L ++ +L+ D+ +
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804
Query: 501 MLT--SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTL 558
L K+ ++ +L L V + V L+ KE T E +
Sbjct: 1805 QLALKGGKKQIQ-KLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1863
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ LQ++ + ++ + K + E+ E + S+ + L+ E+E+
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQ-AEEAEEQSNANLSKFRKLQHELEE 1908
>AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein.
Length = 1047
Score = 73.7 bits (173), Expect = 2e-12
Identities = 76/392 (19%), Positives = 182/392 (46%), Gaps = 20/392 (5%)
Query: 133 EIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM 192
E+ Q ++ L++L + + + E R+L+ L+ + H+ E+ A
Sbjct: 476 ELLQAKQDLQDLLIAKEEQEDLLRKRE--RELTALKGALKEEVSSHDQEMDKLKEQYDAE 533
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
+ +R + E K E L + + + + E + + + LQ + E +A+
Sbjct: 534 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 593
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q+++E +KG A A E + E + EAL EEK+A+ ++ ++ E + N
Sbjct: 594 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 653
Query: 313 SIESLKNQMLKEKC-------EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQF 365
S + + + L EK E L +L +++ + + +E++++ ++ ++
Sbjct: 654 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 713
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---LTNNQNSD----LKQELNNLKNCK 418
E + E+ + + + +++++KE + LT + D +++EL + + +
Sbjct: 714 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 773
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
DE T++ + +K L+ EL K+ + ++++++L +E + ++ E L R+
Sbjct: 774 DEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQMEDKV---SQLEMELEEERNNS 829
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+L+ R+ S ++EQ+ +++ +A++ LE
Sbjct: 830 DLLSERISRSREQMEQVRNELLQERAARQDLE 861
Score = 59.7 bits (138), Expect = 4e-08
Identities = 110/514 (21%), Positives = 214/514 (41%), Gaps = 38/514 (7%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET---QQRLEMVKGHHALALEANESI- 273
Q+E+ + + + R+ + +L+E + + + E QQRLE +G LE +
Sbjct: 376 QLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 435
Query: 274 --RREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESL--KNQMLKEKCEAL 329
R +++ E+ L+ +L E + S K ++ K A IE L Q L++ A
Sbjct: 436 MEREQHQTEIRDLQDQLSEMHDELDS-AKRSEDREK---GALIEELLQAKQDLQDLLIAK 491
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
E+ L +E+E+ A ++E S +++ + Q++ Q+++E + K ++ L
Sbjct: 492 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 551
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK-DELIEKTI- 444
+ T + L++E L+ +EL +I+ LK DE K
Sbjct: 552 ASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 611
Query: 445 -NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
YE E +L A+ A KE+ + ++ + + L ++ E +QL ++++ +
Sbjct: 612 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 671
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
KE +L KN + N + + ++ K+ L KE I+E + T LQ
Sbjct: 672 EQKE----QLRRLKNEMEN-----ERW-----HLGKTIEKLQKEMADIVEASRTSTLELQ 717
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXX 621
N + + Y+E + EL E LK+++ + + +++ + L E
Sbjct: 718 N-QLDEYKEKN--RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 774
Query: 622 XXXXSRVLLAQAAADLS-RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
R LL Q DL LE ++ + ++S L E EE S
Sbjct: 775 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 834
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
I + ++ +EQ + R+ L+ K +++
Sbjct: 835 RISRSREQMEQVRNELLQERAARQDLECDKISLE 868
Score = 57.2 bits (132), Expect = 2e-07
Identities = 85/401 (21%), Positives = 168/401 (41%), Gaps = 21/401 (5%)
Query: 218 QMELSSLEEVITVRDSLCKDLQEKLTSNE-LTLAETQQRLEMVKGHHALALEANESIRRE 276
Q EL+ T + L L+E T N+ T + E ++ + A + + +
Sbjct: 288 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 347
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E +K L+++ + I ++ ++ L+ K+ +I+ + +M + E L H++
Sbjct: 348 CNSTSE-VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM-RANLEELRSQHNE 405
Query: 336 LIIKEQEMKAKLEQIEESASEKL-KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
+ + ++ +LE+ E + L ++ +++ ER Q E Q++ + + E+ K
Sbjct: 406 KVEENSTLQQRLEESEGELRKNLEELFQVKM-EREQHQTEIRDLQDQ-LSEMHDELDSAK 463
Query: 395 YTLDLTN----NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+ D + KQ+L +L K+E E+ LK L E+ +++ E
Sbjct: 464 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 523
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
+KL E+ E S+ V VL R S+ + E +V++L E L+
Sbjct: 524 DKLK---EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 580
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+ + R+ ++ K + K+K L K I + L+ + + EKEA
Sbjct: 581 GRSEELERRVAQLQRQIEDLKG---DEAKAKETLKKYEGEIRQLEEALVHA-RKEEKEAV 636
Query: 571 RELGTIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
++NEL L + + Q + L+EE E+K L
Sbjct: 637 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL 677
Score = 50.4 bits (115), Expect = 2e-05
Identities = 81/397 (20%), Positives = 160/397 (40%), Gaps = 28/397 (7%)
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFE 366
TK ++ K Q LK + Q ++Q E+K LEQ + E ++ ++Q E
Sbjct: 319 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLE 378
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKE-------LKYTLDLTNNQNSDLKQELNNLKNCK 418
+ Q+I+E + ++ L + E L+ L+ + + +EL +K +
Sbjct: 379 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 438
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
++ TE + +++ + DEL + + EK L +E+ ++ K + L +
Sbjct: 439 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL---IEELLQAKQDLQDLLIAKEEQE 495
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV--- 535
+L R RE + L+++V + L+ + L +V E + E L
Sbjct: 496 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 555
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
N + A T+ ++++ E LQ +E R + ++ + IED++ + ++ +
Sbjct: 556 NTSEQDQAGTEMRVKLLQEE---NEKLQGRSEELERRVAQLQRQ-IEDLKGDEAKAKETL 611
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL---LAQAAADLSRLENENERYXXXXX 652
K E+ R L E R L L A +LS+ E ++
Sbjct: 612 KKYEGEI---RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 668
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
+L L+ E E + K I+KL+K++
Sbjct: 669 EESEQKEQLRRLKNEMENERWHLGK---TIEKLQKEM 702
Score = 48.0 bits (109), Expect = 1e-04
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 30/358 (8%)
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ------EIKELKYTLDLTNNQNSDLKQ 409
EK++ + + +Q + C+ + LEQ E+ EL+ L L ++K+
Sbjct: 328 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 387
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
E ++ +EL ++ +EE TL+ L E + +L +E+ + K + E
Sbjct: 388 ERERMRANLEELRSQHNEKVEENSTLQQRL-------EESEGELRKNLEELFQVKMEREQ 440
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKEVLENELTTYKNTLNNTV 524
+ RD+ L+ E DS ++ ED+ ++ L AK+ L+ +L K + +
Sbjct: 441 HQTEIRDLQDQLSEMHDELDS-AKRSEDREKGALIEELLQAKQDLQ-DLLIAKEEQEDLL 498
Query: 525 RECDEYKEALVNILKSK-AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
R+ + AL LK + ++ +E ++ E +++L+ +EA + + + +
Sbjct: 499 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR-SNT 557
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E + + ++K L+EE EK + E + A+A L + E E
Sbjct: 558 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 617
Query: 644 NERYXXXXXXXXSLVVELSLLRQ--ENE------ELTMTVAKQSSIIDKLKKDLEQSQ 693
+ E R+ ENE L+ T +Q + +KLK++ EQ +
Sbjct: 618 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 675
Score = 46.0 bits (104), Expect = 5e-04
Identities = 60/312 (19%), Positives = 132/312 (42%), Gaps = 29/312 (9%)
Query: 125 KQIEDYKNEIAQLQEILK----ELATKFRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEH 178
K IE + E+A + E + EL + + N + E+ R+L + +
Sbjct: 693 KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 752
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
+Q + + + D + E K + L+ + D + EL + + R L K +
Sbjct: 753 MKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQM 811
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY------KIELEALKTKLDEEK 292
++K++ E+ L E + +++ + + E E +R E + +LE K L+ +
Sbjct: 812 EDKVSQLEMELEEERNNSDLLSERISRSREQMEQVRNELLQERAARQDLECDKISLERQN 871
Query: 293 QAIISKC-------KVDQENLKTKHNASIESLKNQMLKEKCEA---------LEQLHSQL 336
+ + S+ + +E L + A I L++++ E+ + LE+ +L
Sbjct: 872 KDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL 931
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
+++ + L ++ S +LK + Q EE + I S ++K + LE+++ ++
Sbjct: 932 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 991
Query: 397 LDLTNNQNSDLK 408
N+ DL+
Sbjct: 992 QGQLNSMKKDLR 1003
Score = 42.7 bits (96), Expect = 0.004
Identities = 54/285 (18%), Positives = 140/285 (49%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 728 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL-LEQT 786
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 787 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER----NNSDLLSERI-SRSRE 841
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E ++N++L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 842 QMEQVRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 901
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 902 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 961
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 962 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 1005
>X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain
(1151 AA) protein.
Length = 1151
Score = 73.3 bits (172), Expect = 3e-12
Identities = 126/638 (19%), Positives = 260/638 (40%), Gaps = 50/638 (7%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+QA++ ++ + + +Q++D + + Q +++ +L R+ ++ + +
Sbjct: 226 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ--ESIM 283
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE 225
L N+ E + + ++A I D ++ +L+KK + L + + + EL +
Sbjct: 284 DLE-NDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 342
Query: 226 EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY-KIELEAL 284
+ L DL +L E +RLE G ++ +E N+ E+ K+ +
Sbjct: 343 TARAKVEKLRSDLSRELE-------EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 395
Query: 285 KTKLDEEKQAI-ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ L E A + K D + +++ +K ++ KEK E +L EQ +
Sbjct: 396 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 455
Query: 344 KAK--LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD--- 398
KAK LE++ + +++ + EE +S+ + SQ+ K L+ E EL LD
Sbjct: 456 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTENGELSRQLDEKE 511
Query: 399 ----------LTNNQN-SDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
LT Q DLK++L K+ L+ + + L+++ E+T
Sbjct: 512 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 571
Query: 448 NEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDSELEQLEDQVQMLT 503
+ L+ A + + + K+ET ++ T ++ L RL+E++ +E + + L
Sbjct: 572 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 631
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
K L+NE+ L V + AL ++ + E + E + + +ES Q
Sbjct: 632 KTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 687
Query: 564 NVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEKKRVLCEMXXXXXX 617
+ EL +KN E +E +E K+E+ + +I L E++
Sbjct: 688 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 747
Query: 618 XXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-LLRQENEELTMTVA 676
+ L +A A LE+E + + E+ L +++EE+
Sbjct: 748 QLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 804
Query: 677 KQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
++D L+ L+ + ++K ++ M+
Sbjct: 805 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 842
Score = 72.9 bits (171), Expect = 4e-12
Identities = 102/527 (19%), Positives = 230/527 (43%), Gaps = 58/527 (11%)
Query: 123 YNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF------------NEIDRKLSKLRIN 170
Y +Q+ED K ++ + + LA + + ++ D E+ R LSK
Sbjct: 524 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 583
Query: 171 NTNCHTEH--NAVQGTDA-----EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
T++ +A+Q T+ +K++ + + + + KC +L+ + Q E+
Sbjct: 584 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 643
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L + ++ L +K + + LAE +Q+ E + LE+++ R EL
Sbjct: 644 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE----LESSQKEARSLSTELFK 699
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
LK +E + + K + +NL+ + + E L + + LE++ QL ++ E+
Sbjct: 700 LKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGSS--GKTIHELEKVRKQLEAEKMEL 756
Query: 344 KAKLEQIEESASE---KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE----IKELKYT 396
++ LE+ E S K+ +++F + I+ +++++ ++ ++ + L+ +
Sbjct: 757 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 816
Query: 397 LDL-TNNQNSDL---KQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTINYE-- 447
LD T ++N L K+ +L + +LS E ++K+L+ L + I +
Sbjct: 817 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 876
Query: 448 ---NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
N+ K N+A+ + + N + L R +V + +D EL + ++VQ+L S
Sbjct: 877 VRANDDLKENIAIVE--RRNNLLQAELEELRAVVEQTERSRKLADEELIETSERVQLLHS 934
Query: 505 A-------KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
K+ ++ +L+ + + V+EC +E + A + +E + + +
Sbjct: 935 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA- 993
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
L+ ++K + + +++ L E ++ K Q++ L V +
Sbjct: 994 ---HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1037
Score = 70.9 bits (166), Expect = 1e-11
Identities = 115/539 (21%), Positives = 215/539 (39%), Gaps = 34/539 (6%)
Query: 92 LTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQS 151
L + I+ + Q + ++ KD + N +IED + +QLQ+ LKEL + +
Sbjct: 275 LKLTQESIMDLENDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 334
Query: 152 HNNIDFNEIDR-KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL 210
++ R K+ KLR + + E + S I + R E +K L
Sbjct: 335 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 394
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE-- 268
+ + ++L + DS+ +L E++ + L +Q+LE K L L+
Sbjct: 395 EEATLQHEATAAALRK--KHADSVA-ELGEQIDN----LQRVKQKLEKEKSEFKLELDDV 447
Query: 269 -ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK--TKHNASIESLKNQMLKEK 325
+N + K LE + L+++ SK + Q ++ T A +++ +N L +
Sbjct: 448 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT-ENGELSRQ 506
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
+ E L SQL + +LE ++ E++K + QS + C + +
Sbjct: 507 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK-AKNALAHALQSARHDCDLLREQYEE 565
Query: 386 LEQEIKELKYTLDLTNNQ--------NSDLKQELNNLKNCKDELSTEKFNFIEEIKTL-- 435
+ EL+ L N++ +D Q L+ K +L+ E ++ +
Sbjct: 566 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 625
Query: 436 KDELIEKTIN-YENEKNKLNLAVEKA-------IKEKNKFETSLSVTRDIVHVLTLRLRE 487
K +EKT + +NE L + VE++ K++ F+ L+ + L
Sbjct: 626 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 685
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
S E L ++ L +A E L T+K N E + E L + K+ L K
Sbjct: 686 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 745
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
++ + L +L+ E E G I +E +K E ++ EE+E+ +
Sbjct: 746 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 803
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/451 (21%), Positives = 191/451 (42%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + +TI E K + + E +L
Sbjct: 698 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKMEL 756
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 757 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 816
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ + ++KK E NE+ +++LS + K LQ L ++
Sbjct: 817 LDAETRS-RNEALRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 872
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ D+E ++T
Sbjct: 873 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLADEELIET 925
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + ++ SQL + +E + EE A + + + EE
Sbjct: 926 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 985
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + ++EL
Sbjct: 986 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1044
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E+++ NL +D+V L
Sbjct: 1045 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR----------------LQDLVDKLQ 1088
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 1089 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1119
Score = 67.7 bits (158), Expect = 1e-10
Identities = 140/637 (21%), Positives = 271/637 (42%), Gaps = 63/637 (9%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q++ ++ +A +E +L Q + E++ +L N + ++ +
Sbjct: 106 QVQAEQDNLADAEERCDQLIKNKIQLEAKV--KEMNERLEDEEEMNAELTAKKRKLED-E 162
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE--KLT 243
++ I+D+ + ++EK+ A +N+V + E++ L+E+I K LQE +
Sbjct: 163 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 222
Query: 244 SNELTLAETQQRLEMVKGHHALALEANE---SIRREYKI--ELEALKTKLDEE---KQAI 295
++L AE + + K L + ++ S+ +E K+ +LE K KL+ + Q
Sbjct: 223 LDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 281
Query: 296 ISKCKVD----QENLKTKH------NASIE---SLKNQM---LKEKCEALEQLHSQLIIK 339
I + D +E LK K NA IE +L +Q+ LKE +E+L +L
Sbjct: 282 IMDLENDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EA 340
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEER--SQSIQ-EHCSQQEKTIQYLEQEIKELKYT 396
E+ +AK+E++ S +L+ + EE + S+Q E ++E Q + ++++E
Sbjct: 341 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 400
Query: 397 LDLT----NNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ T +++D L ++++NL+ K +L EK F E+ + + E+ I +
Sbjct: 401 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAKA 459
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
K+ +E + N+ + T+ V+ LT + + +E +L Q+ KE
Sbjct: 460 NLEKMCRTLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEA 512
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++LT K T ++ ++ K L +K+K AL + H+ L+ E E
Sbjct: 513 LISQLTRGKLTY---TQQLEDLKRQLEEEVKAKNALA-HALQSARHDCDLLREQYEEETE 568
Query: 569 AYRELGTIKNELIEDV-ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSR 627
A EL + ++ +V + K I+ E E K+ L +
Sbjct: 569 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 628
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
L RL+NE E + L +Q N + + KQ ++ +
Sbjct: 629 SL----EKTKHRLQNEIEDLMVDVERSNAAAAALD-KKQRNFDKILAEWKQK--YEESQS 681
Query: 688 DLEQSQYTPKSPSV-LRKSLKVGKENMQTISPLRERN 723
+LE SQ +S S L K +E+++ + + N
Sbjct: 682 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 718
Score = 65.7 bits (153), Expect = 5e-10
Identities = 85/414 (20%), Positives = 184/414 (44%), Gaps = 27/414 (6%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I L K E + E+ + E + L+E + ++ K+L+EK+ S + Q +++
Sbjct: 51 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 109
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK 318
+ + A A E + + + KI+LEA +++E + D+E + + A L+
Sbjct: 110 EQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLE--------DEEEMNAELTAKKRKLE 160
Query: 319 NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEHC 376
++ + K + ++ L L E+E A +++ E + EI + + +++QE
Sbjct: 161 DECSELKRD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 219
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
Q +Q E ++ L Q DL+ L K + +L K ++K +
Sbjct: 220 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 279
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+ +++ EN+K +L ++K E N + + + L +L+E + +E+LE
Sbjct: 280 ESIMD----LENDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 335
Query: 497 DQVQMLTSAK---EVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
++++ +A+ E L ++L+ ++ + E + + K + A ++ R +E
Sbjct: 336 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 395
Query: 554 -----HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
H T +L+ ++ ELG + L + L+KE S+ K ++V
Sbjct: 396 EATLQHEAT-AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDV 447
Score = 64.9 bits (151), Expect = 1e-09
Identities = 84/367 (22%), Positives = 156/367 (42%), Gaps = 35/367 (9%)
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L AE ++ + +K EA E K ELE L +EK + + + +Q+NL
Sbjct: 56 LKSAEREKEMASMKEEFTRLKEALEKSEARRK-ELEEKMVSLLQEKNDLQLQVQAEQDNL 114
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFE 366
A E +Q++K K QL K +EM +LE EE +E
Sbjct: 115 -----ADAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAE--------LT 153
Query: 367 ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
+ + +++ CS+ ++ I LE + +++ T N+ +L +E+ L +L+ EK
Sbjct: 154 AKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 213
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + D+L + E++ N L A K ++ + E SL + + L R
Sbjct: 214 ALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 269
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVRECDEYKEALVNILKSKAA 543
+ + +L+ ++ + L + K+ LE L N LN + + L LK A
Sbjct: 270 KLEGDLKLTQESIMDLENDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 329
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVEL-LKKESNSQIKF 597
+E +E T ++ + + REL I L E V++ + K+ ++ +
Sbjct: 330 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 389
Query: 598 LREEVEK 604
+R ++E+
Sbjct: 390 MRRDLEE 396
Score = 54.4 bits (125), Expect = 1e-06
Identities = 64/321 (19%), Positives = 146/321 (45%), Gaps = 24/321 (7%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
D ++ ++ E +K+ ++L + + D Q++L ++ + D L +++
Sbjct: 837 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL---DDAVRANDDLKENIAIVERR 893
Query: 245 NELTLAETQQ-RLEMVKGHHALALEANESIRREYKIEL-EALKTKLDEEKQAIISKCKVD 302
N L AE ++ R + + + L E I +++L + T L +K+ K D
Sbjct: 894 NNLLQAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQNTSLINQKK----KMDAD 949
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQ-LHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+T+ +++ +N K K + + ++ + KEQ+ A LE+++++ + +K
Sbjct: 950 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1009
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL 421
+ + +E Q + +Q +Q LE ++EL+ L+ +N++ + + + EL
Sbjct: 1010 QHRLDEAEQIALKGGKKQ---LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL 1066
Query: 422 STEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
+ + + + L+D L++K + K+ +A + + + T+LS R + H
Sbjct: 1067 TYQTEEDRKNLLRLQD-LVDKL------QLKVKAYKRQAEEAEEQANTNLSKFRKVQH-- 1117
Query: 482 TLRLRESDSELEQLEDQVQML 502
L E++ + E QV L
Sbjct: 1118 --ELDEAEERADIAESQVNKL 1136
>BC113524-1|AAI13525.1| 578|Homo sapiens IFT74 protein protein.
Length = 578
Score = 73.3 bits (172), Expect = 3e-12
Identities = 110/488 (22%), Positives = 220/488 (45%), Gaps = 44/488 (9%)
Query: 111 VEIRNKDQTI-CEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRI 169
+E+ N++ ++ Y K+ E EI +LQ L + + + N + E+ + L+
Sbjct: 97 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKA 156
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC--EALDNEVYDKQMELSSL--- 224
N T+ V T+ + I + IE EK+ + + N ++ Q++ +
Sbjct: 157 QNDR-ETQSLDVIFTERQAKEKQIRSVEEE-IEQEKQATDDIIKNMSFENQVKYLEMKTT 214
Query: 225 -EEVITVRDSLCKDLQE---KLTSNELTLAETQQRLEMVKGHHAL-ALEA--NESIRREY 277
E+++ D+L + L K S E +A +Q + E V H L LE+ ++ I +
Sbjct: 215 NEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDK 274
Query: 278 KI-----ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKCEALE 330
I E E L ++ ++ Q I S + + K K N IE ++ + L+E +
Sbjct: 275 SIGSPMEEREKLLKQIKDDNQEIAS-MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 333
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ-E 389
Q + +L +E+ M +E EE+ +++LK + Q E ++ EHCS+ I+ +
Sbjct: 334 QKYKELKKREEHMDTFIETFEETKNQELK-RKAQIEANIVALLEHCSRNINRIEQISSIT 392
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKD-----ELSTEKFNFI-----EEIKTLKDEL 439
+ELK D N +++++++ + +N +L +K + EE +LK ++
Sbjct: 393 NQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKI 452
Query: 440 IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+ T + E N+ L + E+ IK+ ++ LS R+ + + + + E E L+
Sbjct: 453 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKI---MEKQNIEYEALKT 509
Query: 498 QVQMLTSAKEVLENELTTYKNTLNN-TVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
Q+Q + ++ E NN ++E K + K +TK+ I E+N
Sbjct: 510 QLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQ---IAEYNK 566
Query: 557 TLIESLQN 564
T++++L +
Sbjct: 567 TIVDALHS 574
Score = 58.8 bits (136), Expect = 6e-08
Identities = 88/441 (19%), Positives = 184/441 (41%), Gaps = 27/441 (6%)
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ--MLKEKCEAL 329
S+ Y+ E L ++ +E Q ++ + + L T N +E + N MLK + +
Sbjct: 105 SVYLSYEKRAETLAVEI-KELQGQLADYNMLVDKLNT--NTEMEEVMNDYNMLKAQNDRE 161
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
Q + + Q + ++ +EE ++ + + + S Q + + T + L QE
Sbjct: 162 TQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQE 221
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELI--EKTIN 445
+ L+ LD N + L+ E+ + K E L EK + E+++ +D++I +K+I
Sbjct: 222 LDTLQQQLDSQNMKKESLEAEIAH-SQVKQEAVLLHEK---LYELESHRDQMIAEDKSIG 277
Query: 446 YE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
E+ KL ++ +E E L+ T++ ++ +R+ D +LE E Q +M
Sbjct: 278 SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE--EHQGEMNQK 335
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
KE+ + E + +T T E + LK KA + ++EH I ++
Sbjct: 336 YKELKKRE--EHMDTFIETFEETKNQE------LKRKAQIEANIVALLEHCSRNINRIEQ 387
Query: 565 VEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXX 623
+ +EL ++++L + E+ K +S +Q L ++++ ++ +
Sbjct: 388 ISSITNQELKMMQDDLNFKSTEVQKSQSTAQ--NLTSDIQRLQLDLQKMELLESKMTEEQ 445
Query: 624 XXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIID 683
+ + Q DL + L E +L + KQ+ +
Sbjct: 446 HSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYE 505
Query: 684 KLKKDLEQSQYTPKSPSVLRK 704
LK L++++ + ++ RK
Sbjct: 506 ALKTQLQENETHSQLTNLERK 526
Score = 36.7 bits (81), Expect = 0.29
Identities = 64/315 (20%), Positives = 137/315 (43%), Gaps = 25/315 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
+D+++ A+D I + + + KQI+D EIA ++ L + K Q I ++D
Sbjct: 266 RDQMI-AEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMD 324
Query: 162 RKLSKLRINNTNCH-TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME 220
+ + +N + T E N R ++E AL +
Sbjct: 325 LEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVAL---LEHCSRN 381
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKI 279
++ +E++ ++ + K +Q+ L + ++Q + + L L+
Sbjct: 382 INRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ--------- 432
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
++E L++K+ EE+ ++ SK K +L+ ++ + +LK+ +EK +++LH + +I
Sbjct: 433 KMELLESKMTEEQHSLKSKIKQMTTDLEIYND--LPALKSSG-EEK---IKKLHQERMIL 486
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
A ++I E + + + + Q +E Q + E+ Q+LEQ +K +
Sbjct: 487 STHRNA-FKKIMEKQNIEYEALKTQLQENETHSQ--LTNLERKWQHLEQNNFAMKEFI-A 542
Query: 400 TNNQNSDLKQELNNL 414
T +Q SD + N+
Sbjct: 543 TKSQESDYQPIKKNV 557
>AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein.
Length = 983
Score = 73.3 bits (172), Expect = 3e-12
Identities = 107/492 (21%), Positives = 209/492 (42%), Gaps = 36/492 (7%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQS---HNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
K D I QLQEIL++L + S + R+ + +NNT +E+++
Sbjct: 425 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-SENSSD 483
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKC-------EALDNEVYDKQMELSSLEEVITVRDSL 234
++ + + ++ ++K+ E++DN Y EL EE I V L
Sbjct: 484 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN--YSHFHELRVTEEEINV---L 538
Query: 235 CKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
+DLQ L +E + ++ E +V+ ++ E K ++ +++EK
Sbjct: 539 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 598
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
+ K + QE + K +++S Q ++ E +++ +++I + + ++L Q+ +
Sbjct: 599 FLFEKYQEAQEEI-MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE 657
Query: 354 ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
A +L+ + + + H ++ EK +Q + + L +Q S + EL
Sbjct: 658 AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELT 717
Query: 413 NLKNCKDELS------TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
LK D TE I ++T E+ EK N +++ + VE A EK
Sbjct: 718 QLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNL--KEHLASKEVEVAKLEKQL 775
Query: 467 FETSLSVTRDIVHVLTLRLRES--DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
E ++T +V + +S +SE+ L +++ KE + +E+ ++ ++
Sbjct: 776 LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVK 835
Query: 525 RECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIK--NELI 581
RE KE + +LKSK E + + L E + E + E K NE+
Sbjct: 836 RE----KENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMS 891
Query: 582 EDVELLKKESNS 593
++V LK+ NS
Sbjct: 892 KEVTKLKEALNS 903
Score = 48.8 bits (111), Expect = 7e-05
Identities = 101/534 (18%), Positives = 231/534 (43%), Gaps = 72/534 (13%)
Query: 98 KILPQDELVQAQ-DVEIRNKD-QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L E + Q VE++++ + +C N +I + ++++Q LKE +K+ ++ +
Sbjct: 446 KRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK---LKETQSKYEEAMKEV 502
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ KL + + + ++ + ++ T+ E+++ + D+++ + E E+ E + E+
Sbjct: 503 LSVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLKQDLQNALEESERNKEKV-RELE 560
Query: 216 DKQMELSS-------LEEVITVRDSLCKDLQEKLTSNELTLAETQQRL--EMVKGHHALA 266
+K +E +EE ++ S C + E + + L E Q E++K L
Sbjct: 561 EKLVEREKGTVIKPPVEEYEEMKSSYCSVI-ENMNKEKAFLFEKYQEAQEEIMKLKDTLK 619
Query: 267 LEANESIRREYKIELEALKTKLDE------EKQAIISKCKVDQENLKTK----------- 309
+ + E + EA+ +DE E + + + + E+ + +
Sbjct: 620 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 679
Query: 310 HNASIESLKN--QMLKEKCE-ALEQLHSQL--IIKE-QEMKAKLEQIEE---SASEKLKI 360
H A E L + + K E AL ++ SQ ++ E ++K ++ +E S +E L++
Sbjct: 680 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 739
Query: 361 CEI------QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ EE+ +++EH + +E + LE+++ E K + +D ++
Sbjct: 740 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-------TDAMVPRSSY 792
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+ + L +E ++K E +++ +E ++ V + +EK +T L
Sbjct: 793 EKLQSSLESEVSVLASKLK----ESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 848
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
V+ L + +++ EL +++ + + +E + + +N +E + KEAL
Sbjct: 849 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKK-------INEMSKEVTKLKEAL 901
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK 588
N L + T R + +E+LQ K+ +L K + E + + +
Sbjct: 902 -NSLSQLSYSTSSSKRQSQQ----LEALQQQVKQLQNQLAECKKQHQEVISVYR 950
Score = 37.1 bits (82), Expect = 0.22
Identities = 59/303 (19%), Positives = 135/303 (44%), Gaps = 25/303 (8%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E+ K ++ A+ ++ L E+ +++ + N + ++ + + + N+ + TEH V
Sbjct: 683 EHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNEL--TQLKQLVDAQKENSVSI-TEHLQV 739
Query: 182 ---QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
T A+++ I++++ + E + L+ ++ +++ ++ + + L L
Sbjct: 740 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL 799
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+ +++ L E+ + E V ++RE + LK+K E + ++ K
Sbjct: 800 ESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNE-LLQK 858
Query: 299 CKVDQENLK-----TKHNASIESLK----NQMLKEKCEALEQLH--SQLIIKEQEMKAKL 347
+ QE L + ++ +E K N+M KE + E L+ SQL K +
Sbjct: 859 FQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQS 918
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY-----LEQEI-KELKYTLDLTN 401
+Q+ E+ +++K + Q E + QE S + Y +++++ K LK L +
Sbjct: 919 QQL-EALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCK 977
Query: 402 NQN 404
NQ+
Sbjct: 978 NQS 980
>AY131226-1|AAN07912.1| 681|Homo sapiens medulloblastoma antigen
MU-MB-20.201 protein.
Length = 681
Score = 73.3 bits (172), Expect = 3e-12
Identities = 108/527 (20%), Positives = 240/527 (45%), Gaps = 29/527 (5%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIED-YKNEIAQLQEILKELATKFRQSHNNI--DFN 158
++E+ Q + + ++ +++ IE + N I +++ +L + + N+ D N
Sbjct: 10 EEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKN 69
Query: 159 EIDRKLSKLR-INNTNCHTEHNAVQGTD--AEKVSAMINDMRSRIIELEKKCEALDNEVY 215
++ ++L L+ + +T + + K + I L+ E L NE+
Sbjct: 70 QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNEL- 128
Query: 216 DKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA--ETQQRLEMVKGHHALALEANESI 273
+ SL+E ++ +L+++ +E T+A + +++L++ K H L ++ E++
Sbjct: 129 --DLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENL 186
Query: 274 RREYKIELEALKTKLDEEKQAIIS---KCKVDQEN-LKTKHNASIESLKNQMLKEKCEAL 329
R+E E L+ + +E+K++ +S + K ++N + +E L NQ+ K + L
Sbjct: 187 RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLK-QNL 245
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
E SQ Q+++A+ Q + +++L+ E Q ++R +S++E Q +E+E
Sbjct: 246 EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKE---AHVLAFQTMEEE 302
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNC-KDELSTEKFNFIEEIKTLKDEL-IEKTINYE 447
KE K L N+ EL +LK+ ++ + + +E++TL+ EL E
Sbjct: 303 -KE-KEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEYEGKAMLA 360
Query: 448 NEKNKLNLAVEKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+ +++LN AI N + + ++ + + R+S + ++ D + L
Sbjct: 361 SLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR 420
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH--NVTLIESLQ 563
+ + ++ N E + IL+ ++ + + R+ E N L + L
Sbjct: 421 EHHISELYKEVQHLHENISALTKELEFKGKEILRIRSE-SNQQIRLHEQDLNKRLEKELD 479
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ + RE ++ + + ELL KE N+ ++ EE+E+K ++ E
Sbjct: 480 VMTADHLREKNIMRADFNKTNELL-KEINAALQVSLEEMEEKYLMRE 525
Score = 66.5 bits (155), Expect = 3e-10
Identities = 94/456 (20%), Positives = 203/456 (44%), Gaps = 29/456 (6%)
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA---LEQLHS-- 334
EL+ L+++L+EE + E L KH+ +IE++ + +++K + LE+ H+
Sbjct: 1 ELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKD 60
Query: 335 QLIIKE--QEMKAKLEQIEESASEKLKIC--EI-QFEERSQSIQEHCSQQEKTIQYLEQE 389
+L ++E +++ +LE ++E +KL EI ++ + ++ E I L+
Sbjct: 61 KLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDS 120
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE---LIEKTINY 446
+ L+ LDLT + LK+ + L N + EL E+ E I +K+E ++K +
Sbjct: 121 QERLQNELDLTKD---SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHD 177
Query: 447 ENEKNKLNLAVE-KAIKEKNKFETSLSVTRDIVHVLTLRLRES----DSELEQLEDQVQM 501
K NL E ++E+ + + + +L L+ RE DS +++ED +
Sbjct: 178 LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQ 237
Query: 502 LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAALTKEHTRIMEHNVTLIE 560
++ K+ LE +L+ + +L + + ++ L L+ + + H + E +V +
Sbjct: 238 ISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQ 297
Query: 561 SLQNVEKEAYREL-GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXX 619
+++ +++ R L ++ + +++ LK ++ R E+E++
Sbjct: 298 TMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEYEGKA 357
Query: 620 XXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQS 679
S L Q AA + L + + + +++S RQ E + Q
Sbjct: 358 MLASLRSE-LNHQHAAAIDLLRHNHHQELAAAKMELERSIDIS-RRQSKEHICRITDLQE 415
Query: 680 SIIDK---LKKDLEQSQYTPKSPSVLRKSLKV-GKE 711
+ + + + ++ Q+ ++ S L K L+ GKE
Sbjct: 416 ELRHREHHISELYKEVQHLHENISALTKELEFKGKE 451
>AY040325-1|AAK77221.1| 600|Homo sapiens capillary morphogenesis
protein-1 protein.
Length = 600
Score = 73.3 bits (172), Expect = 3e-12
Identities = 110/488 (22%), Positives = 220/488 (45%), Gaps = 44/488 (9%)
Query: 111 VEIRNKDQTI-CEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRI 169
+E+ N++ ++ Y K+ E EI +LQ L + + + N + E+ + L+
Sbjct: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKA 178
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC--EALDNEVYDKQMELSSL--- 224
N T+ V T+ + I + IE EK+ + + N ++ Q++ +
Sbjct: 179 QNDR-ETQSLDVIFTERQAKEKQIRSVEEE-IEQEKQATDDIIKNMSFENQVKYLEMKTT 236
Query: 225 -EEVITVRDSLCKDLQE---KLTSNELTLAETQQRLEMVKGHHAL-ALEA--NESIRREY 277
E+++ D+L + L K S E +A +Q + E V H L LE+ ++ I +
Sbjct: 237 NEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDK 296
Query: 278 KI-----ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKCEALE 330
I E E L ++ ++ Q I S + + K K N IE ++ + L+E +
Sbjct: 297 SIGSPMEEREKLLKQIKDDNQEIAS-MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 355
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ-E 389
Q + +L +E+ M +E EE+ +++LK + Q E ++ EHCS+ I+ +
Sbjct: 356 QKYKELKKREEHMDTFIETFEETKNQELK-RKAQIEANIVALLEHCSRNINRIEQISSIT 414
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKD-----ELSTEKFNFI-----EEIKTLKDEL 439
+ELK D N +++++++ + +N +L +K + EE +LK ++
Sbjct: 415 NQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKI 474
Query: 440 IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+ T + E N+ L + E+ IK+ ++ LS R+ + + + + E E L+
Sbjct: 475 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKI---MEKQNIEYEALKT 531
Query: 498 QVQMLTSAKEVLENELTTYKNTLNN-TVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
Q+Q + ++ E NN ++E K + K +TK+ I E+N
Sbjct: 532 QLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQ---IAEYNK 588
Query: 557 TLIESLQN 564
T++++L +
Sbjct: 589 TIVDALHS 596
Score = 58.8 bits (136), Expect = 6e-08
Identities = 88/441 (19%), Positives = 184/441 (41%), Gaps = 27/441 (6%)
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ--MLKEKCEAL 329
S+ Y+ E L ++ +E Q ++ + + L T N +E + N MLK + +
Sbjct: 127 SVYLSYEKRAETLAVEI-KELQGQLADYNMLVDKLNT--NTEMEEVMNDYNMLKAQNDRE 183
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
Q + + Q + ++ +EE ++ + + + S Q + + T + L QE
Sbjct: 184 TQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQE 243
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELI--EKTIN 445
+ L+ LD N + L+ E+ + K E L EK + E+++ +D++I +K+I
Sbjct: 244 LDTLQQQLDSQNMKKESLEAEIAH-SQVKQEAVLLHEK---LYELESHRDQMIAEDKSIG 299
Query: 446 YE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
E+ KL ++ +E E L+ T++ ++ +R+ D +LE E Q +M
Sbjct: 300 SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE--EHQGEMNQK 357
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
KE+ + E + +T T E + LK KA + ++EH I ++
Sbjct: 358 YKELKKRE--EHMDTFIETFEETKNQE------LKRKAQIEANIVALLEHCSRNINRIEQ 409
Query: 565 VEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXX 623
+ +EL ++++L + E+ K +S +Q L ++++ ++ +
Sbjct: 410 ISSITNQELKMMQDDLNFKSTEVQKSQSTAQ--NLTSDIQRLQLDLQKMELLESKMTEEQ 467
Query: 624 XXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIID 683
+ + Q DL + L E +L + KQ+ +
Sbjct: 468 HSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYE 527
Query: 684 KLKKDLEQSQYTPKSPSVLRK 704
LK L++++ + ++ RK
Sbjct: 528 ALKTQLQENETHSQLTNLERK 548
Score = 36.7 bits (81), Expect = 0.29
Identities = 64/315 (20%), Positives = 137/315 (43%), Gaps = 25/315 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
+D+++ A+D I + + + KQI+D EIA ++ L + K Q I ++D
Sbjct: 288 RDQMI-AEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMD 346
Query: 162 RKLSKLRINNTNCH-TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME 220
+ + +N + T E N R ++E AL +
Sbjct: 347 LEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVAL---LEHCSRN 403
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKI 279
++ +E++ ++ + K +Q+ L + ++Q + + L L+
Sbjct: 404 INRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ--------- 454
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
++E L++K+ EE+ ++ SK K +L+ ++ + +LK+ +EK +++LH + +I
Sbjct: 455 KMELLESKMTEEQHSLKSKIKQMTTDLEIYND--LPALKSSG-EEK---IKKLHQERMIL 508
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
A ++I E + + + + Q +E Q + E+ Q+LEQ +K +
Sbjct: 509 STHRNA-FKKIMEKQNIEYEALKTQLQENETHSQ--LTNLERKWQHLEQNNFAMKEFI-A 564
Query: 400 TNNQNSDLKQELNNL 414
T +Q SD + N+
Sbjct: 565 TKSQESDYQPIKKNV 579
>AL356133-4|CAH72643.1| 600|Homo sapiens intraflagellar transport
74 homolog (Chlamydomonas) protein.
Length = 600
Score = 73.3 bits (172), Expect = 3e-12
Identities = 110/488 (22%), Positives = 220/488 (45%), Gaps = 44/488 (9%)
Query: 111 VEIRNKDQTI-CEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRI 169
+E+ N++ ++ Y K+ E EI +LQ L + + + N + E+ + L+
Sbjct: 119 IEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKA 178
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC--EALDNEVYDKQMELSSL--- 224
N T+ V T+ + I + IE EK+ + + N ++ Q++ +
Sbjct: 179 QNDR-ETQSLDVIFTERQAKEKQIRSVEEE-IEQEKQATDDIIKNMSFENQVKYLEMKTT 236
Query: 225 -EEVITVRDSLCKDLQE---KLTSNELTLAETQQRLEMVKGHHAL-ALEA--NESIRREY 277
E+++ D+L + L K S E +A +Q + E V H L LE+ ++ I +
Sbjct: 237 NEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDK 296
Query: 278 KI-----ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLK--NQMLKEKCEALE 330
I E E L ++ ++ Q I S + + K K N IE ++ + L+E +
Sbjct: 297 SIGSPMEEREKLLKQIKDDNQEIAS-MERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMN 355
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ-E 389
Q + +L +E+ M +E EE+ +++LK + Q E ++ EHCS+ I+ +
Sbjct: 356 QKYKELKKREEHMDTFIETFEETKNQELK-RKAQIEANIVALLEHCSRNINRIEQISSIT 414
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKD-----ELSTEKFNFI-----EEIKTLKDEL 439
+ELK D N +++++++ + +N +L +K + EE +LK ++
Sbjct: 415 NQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKI 474
Query: 440 IEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
+ T + E N+ L + E+ IK+ ++ LS R+ + + + + E E L+
Sbjct: 475 KQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKI---MEKQNIEYEALKT 531
Query: 498 QVQMLTSAKEVLENELTTYKNTLNN-TVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
Q+Q + ++ E NN ++E K + K +TK+ I E+N
Sbjct: 532 QLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQ---IAEYNK 588
Query: 557 TLIESLQN 564
T++++L +
Sbjct: 589 TIVDALHS 596
Score = 58.8 bits (136), Expect = 6e-08
Identities = 88/441 (19%), Positives = 184/441 (41%), Gaps = 27/441 (6%)
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ--MLKEKCEAL 329
S+ Y+ E L ++ +E Q ++ + + L T N +E + N MLK + +
Sbjct: 127 SVYLSYEKRAETLAVEI-KELQGQLADYNMLVDKLNT--NTEMEEVMNDYNMLKAQNDRE 183
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
Q + + Q + ++ +EE ++ + + + S Q + + T + L QE
Sbjct: 184 TQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQE 243
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELI--EKTIN 445
+ L+ LD N + L+ E+ + K E L EK + E+++ +D++I +K+I
Sbjct: 244 LDTLQQQLDSQNMKKESLEAEIAH-SQVKQEAVLLHEK---LYELESHRDQMIAEDKSIG 299
Query: 446 YE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
E+ KL ++ +E E L+ T++ ++ +R+ D +LE E Q +M
Sbjct: 300 SPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLE--EHQGEMNQK 357
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
KE+ + E + +T T E + LK KA + ++EH I ++
Sbjct: 358 YKELKKRE--EHMDTFIETFEETKNQE------LKRKAQIEANIVALLEHCSRNINRIEQ 409
Query: 565 VEKEAYRELGTIKNEL-IEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXX 623
+ +EL ++++L + E+ K +S +Q L ++++ ++ +
Sbjct: 410 ISSITNQELKMMQDDLNFKSTEVQKSQSTAQ--NLTSDIQRLQLDLQKMELLESKMTEEQ 467
Query: 624 XXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIID 683
+ + Q DL + L E +L + KQ+ +
Sbjct: 468 HSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYE 527
Query: 684 KLKKDLEQSQYTPKSPSVLRK 704
LK L++++ + ++ RK
Sbjct: 528 ALKTQLQENETHSQLTNLERK 548
Score = 36.7 bits (81), Expect = 0.29
Identities = 64/315 (20%), Positives = 137/315 (43%), Gaps = 25/315 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
+D+++ A+D I + + + KQI+D EIA ++ L + K Q I ++D
Sbjct: 288 RDQMI-AEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMD 346
Query: 162 RKLSKLRINNTNCH-TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME 220
+ + +N + T E N R ++E AL +
Sbjct: 347 LEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVAL---LEHCSRN 403
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKI 279
++ +E++ ++ + K +Q+ L + ++Q + + L L+
Sbjct: 404 INRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQ--------- 454
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
++E L++K+ EE+ ++ SK K +L+ ++ + +LK+ +EK +++LH + +I
Sbjct: 455 KMELLESKMTEEQHSLKSKIKQMTTDLEIYND--LPALKSSG-EEK---IKKLHQERMIL 508
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
A ++I E + + + + Q +E Q + E+ Q+LEQ +K +
Sbjct: 509 STHRNA-FKKIMEKQNIEYEALKTQLQENETHSQ--LTNLERKWQHLEQNNFAMKEFI-A 564
Query: 400 TNNQNSDLKQELNNL 414
T +Q SD + N+
Sbjct: 565 TKSQESDYQPIKKNV 579
>AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment
epithelial cell protein protein.
Length = 980
Score = 73.3 bits (172), Expect = 3e-12
Identities = 107/492 (21%), Positives = 209/492 (42%), Gaps = 36/492 (7%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQS---HNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
K D I QLQEIL++L + S + R+ + +NNT +E+++
Sbjct: 422 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-SENSSD 480
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKC-------EALDNEVYDKQMELSSLEEVITVRDSL 234
++ + + ++ ++K+ E++DN Y EL EE I V L
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN--YSHFHELRVTEEEINV---L 535
Query: 235 CKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
+DLQ L +E + ++ E +V+ ++ E K ++ +++EK
Sbjct: 536 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 595
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
+ K + QE + K +++S Q ++ E +++ +++I + + ++L Q+ +
Sbjct: 596 FLFEKYQEAQEEI-MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE 654
Query: 354 ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
A +L+ + + + H ++ EK +Q + + L +Q S + EL
Sbjct: 655 AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELT 714
Query: 413 NLKNCKDELS------TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
LK D TE I ++T E+ EK N +++ + VE A EK
Sbjct: 715 QLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNL--KEHLASKEVEVAKLEKQL 772
Query: 467 FETSLSVTRDIVHVLTLRLRES--DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
E ++T +V + +S +SE+ L +++ KE + +E+ ++ ++
Sbjct: 773 LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVK 832
Query: 525 RECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIK--NELI 581
RE KE + +LKSK E + + L E + E + E K NE+
Sbjct: 833 RE----KENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMS 888
Query: 582 EDVELLKKESNS 593
++V LK+ NS
Sbjct: 889 KEVTKLKEALNS 900
Score = 48.8 bits (111), Expect = 7e-05
Identities = 101/534 (18%), Positives = 231/534 (43%), Gaps = 72/534 (13%)
Query: 98 KILPQDELVQAQ-DVEIRNKD-QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L E + Q VE++++ + +C N +I + ++++Q LKE +K+ ++ +
Sbjct: 443 KRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK---LKETQSKYEEAMKEV 499
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ KL + + + ++ + ++ T+ E+++ + D+++ + E E+ E + E+
Sbjct: 500 LSVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLKQDLQNALEESERNKEKV-RELE 557
Query: 216 DKQMELSS-------LEEVITVRDSLCKDLQEKLTSNELTLAETQQRL--EMVKGHHALA 266
+K +E +EE ++ S C + E + + L E Q E++K L
Sbjct: 558 EKLVEREKGTVIKPPVEEYEEMKSSYCSVI-ENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 267 LEANESIRREYKIELEALKTKLDE------EKQAIISKCKVDQENLKTK----------- 309
+ + E + EA+ +DE E + + + + E+ + +
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 310 HNASIESLKN--QMLKEKCE-ALEQLHSQL--IIKE-QEMKAKLEQIEE---SASEKLKI 360
H A E L + + K E AL ++ SQ ++ E ++K ++ +E S +E L++
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 736
Query: 361 CEI------QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ EE+ +++EH + +E + LE+++ E K + +D ++
Sbjct: 737 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-------TDAMVPRSSY 789
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+ + L +E ++K E +++ +E ++ V + +EK +T L
Sbjct: 790 EKLQSSLESEVSVLASKLK----ESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSK 845
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
V+ L + +++ EL +++ + + +E + + +N +E + KEAL
Sbjct: 846 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKK-------INEMSKEVTKLKEAL 898
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLK 588
N L + T R + +E+LQ K+ +L K + E + + +
Sbjct: 899 -NSLSQLSYSTSSSKRQSQQ----LEALQQQVKQLQNQLAECKKQHQEVISVYR 947
Score = 37.1 bits (82), Expect = 0.22
Identities = 59/303 (19%), Positives = 135/303 (44%), Gaps = 25/303 (8%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
E+ K ++ A+ ++ L E+ +++ + N + ++ + + + N+ + TEH V
Sbjct: 680 EHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNEL--TQLKQLVDAQKENSVSI-TEHLQV 736
Query: 182 ---QGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
T A+++ I++++ + E + L+ ++ +++ ++ + + L L
Sbjct: 737 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL 796
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+ +++ L E+ + E V ++RE + LK+K E + ++ K
Sbjct: 797 ESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNE-LLQK 855
Query: 299 CKVDQENLK-----TKHNASIESLK----NQMLKEKCEALEQLH--SQLIIKEQEMKAKL 347
+ QE L + ++ +E K N+M KE + E L+ SQL K +
Sbjct: 856 FQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQS 915
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY-----LEQEI-KELKYTLDLTN 401
+Q+ E+ +++K + Q E + QE S + Y +++++ K LK L +
Sbjct: 916 QQL-EALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCK 974
Query: 402 NQN 404
NQ+
Sbjct: 975 NQS 977
>L01042-1|AAD54608.1| 1093|Homo sapiens TATA element modulatory
factor protein.
Length = 1093
Score = 72.9 bits (171), Expect = 4e-12
Identities = 97/467 (20%), Positives = 200/467 (42%), Gaps = 48/467 (10%)
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVS 190
K E + + + E + ++ + +R +K I N E A + +E
Sbjct: 490 KEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIK---EELATRLNSSETAD 546
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
++ + +I L ++ E L + Q+ S++ + + +D +++ KL L
Sbjct: 547 -LLKEKDEQIRGLMEEGEKLSKQ----QLHNSNIIKKLRAKDKENENMVAKLNKKVKELE 601
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
E Q L+ V L+ E + ++++ ++ L + ++ +++ + + +VD + L+ K
Sbjct: 602 EELQHLKQV-------LDGKEEVEKQHRENIKKLNSMVERQEKDL-GRLQVDMDELEEK- 652
Query: 311 NASIESLKNQMLKE-----KCEALEQLHSQLIIKEQEMKAK------LEQIEESASEKLK 359
N SI++ + KE K A + +Q +EMKAK LE+ +E A ++ +
Sbjct: 653 NRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQE 712
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
IQ + ++Q + YL EI EL+ L N+N +L Q ++
Sbjct: 713 TLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVS------- 765
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIV 478
ST + + +I+ L+ L +T ++E +EK + ++ + +T L+ +
Sbjct: 766 --STTR-PLLRQIENLQATLGSQTSSWEK--------LEKNLSDRLGESQTLLAAAVERE 814
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
T L + ++ +E Q +L + +L + KN L E + Y+ L N L
Sbjct: 815 RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELEN-L 873
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
K + T E TR + + ++ ++ E R+ E I++ E
Sbjct: 874 KDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKE 920
Score = 64.9 bits (151), Expect = 1e-09
Identities = 97/476 (20%), Positives = 212/476 (44%), Gaps = 28/476 (5%)
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS--RIIE-LEKK 206
+S ++ + D +S IN + A Q AE +++ + +E L +K
Sbjct: 398 RSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEK 457
Query: 207 CEALDNEVYDKQMELSSLEEVI-TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL 265
E + ++ E + LEE ++D + + +E + + L E QR+ + L
Sbjct: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLK-DEFTQRIAEAEKKVQL 516
Query: 266 ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN--LKTKHNASIESLKNQMLK 323
A + ++ ++E K E L T+L+ + A + K K +Q ++ S + L N +
Sbjct: 517 ACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNII 576
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
+K A ++ + ++ K + K++++EE ++ + + EE + +E+ + +
Sbjct: 577 KKLRAKDKENENMVAK---LNKKVKELEEELQHLKQVLDGK-EEVEKQHRENIKKLNSMV 632
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ E+++ L+ +D +N ++ L++ K+ K N ++ E E
Sbjct: 633 ERQEKDLGRLQVDMDELEEKNRSIQAALDSA--YKELTDLHKANAAKD-----SEAQEAA 685
Query: 444 INYE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ-LEDQVQM 501
++ E K +L+ A+EKA +E + + +L++ + + R ++ + E L ++
Sbjct: 686 LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGE 745
Query: 502 LTSAKEVLEN---ELT-TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
L + EN EL+ + +T +R+ + + L + S L K + + + T
Sbjct: 746 LQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQT 805
Query: 558 LIESLQNVEKEAYREL--GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
L+ + E+ A EL I+ +E L ++ NS+ + + E EK R LC++
Sbjct: 806 LLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQ-AQLESEKNR-LCKL 859
Score = 42.3 bits (95), Expect = 0.006
Identities = 97/429 (22%), Positives = 181/429 (42%), Gaps = 40/429 (9%)
Query: 282 EALKTKLDEEKQAIISKC--KVDQENLKTKH-NASIESLKNQMLKEKCEALEQLHSQLII 338
EA L +EK A++ + + E + K ++SI SLK++ + EA +++ QL
Sbjct: 462 EAQLLSLSKEK-ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKV--QLAC 518
Query: 339 KEQEM-KAKLEQIEESASEKLKICEIQ--FEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
KE++ K +++ I+E + +L E +E+ + I+ + EK + +K
Sbjct: 519 KERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIK- 577
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L + +N ++ +LN K K EL E+ ++++ K+E +EK + EN K KLN
Sbjct: 578 KLRAKDKENENMVAKLN--KKVK-ELE-EELQHLKQVLDGKEE-VEKQ-HRENIK-KLNS 630
Query: 456 AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
VE+ K+ + + + + + L DS ++L D L A ++E
Sbjct: 631 MVERQEKDLGRLQVDMDELEEKNRSIQAAL---DSAYKELTD----LHKANAAKDSE--A 681
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR---- 571
+ L+ ++ +E AL + +A +E I ++ L +LQ E+ A R
Sbjct: 682 QEAALSREMKAKEELSAALEKA-QEEARQQQETLAIQVGDLRL--ALQRTEQAAARKEDY 738
Query: 572 ---ELGTIKNELIE----DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXX 624
E+G ++ L E + EL + S++ LR+ + L
Sbjct: 739 LRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSD 798
Query: 625 XSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDK 684
AA + R E S+ + SLLRQEN + + + + K
Sbjct: 799 RLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCK 858
Query: 685 LKKDLEQSQ 693
L+ + + Q
Sbjct: 859 LEDENNRYQ 867
Score = 41.5 bits (93), Expect = 0.010
Identities = 72/348 (20%), Positives = 139/348 (39%), Gaps = 22/348 (6%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEI 160
Q E + Q ++R Q + + EDY ++EI +LQ+ L+E + ++ ++ +
Sbjct: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSV--SST 767
Query: 161 DRKLSKLRINNTNCHTEHNAVQGTDAEK-VSAMINDMRSRIIELEKKCEALDNEVYDKQM 219
R L + +I N EK +S + + ++ + ++ A E+ ++
Sbjct: 768 TRPLLR-QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKI 826
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAET-------QQRLEMVKGHHALALEANES 272
++SS+E ++ Q +L S + L + Q LE +K + LE
Sbjct: 827 QMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK 886
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA--SIESLKNQMLKEKCEALE 330
+ +LE + K+++E++ I QE +K K S+ S ++
Sbjct: 887 EKTLLNSQLEMERMKVEQERKKAI----FTQETIKEKERKPFSVSSTPTMSRSSSISGVD 942
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
Q Q+ S K K ++ S+ +H + ++ E EI
Sbjct: 943 MAGLQTSFLSQDESHDHSFGPMPISAKWKHLYAACKDGSRI--KHIENLQSQLKLREGEI 1000
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-LKD 437
L+ + S + +EL L N DEL EK I +++T L+D
Sbjct: 1001 THLQLEIGNLEKTRSIMAEELVKLTNQNDELE-EKVKEIPKLRTQLRD 1047
>D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein.
Length = 709
Score = 72.9 bits (171), Expect = 4e-12
Identities = 112/538 (20%), Positives = 228/538 (42%), Gaps = 58/538 (10%)
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LEMVKGHHALALE 268
L E+ D + ++ L + + + D +++L E+ L QQ + ++ + +
Sbjct: 174 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 233
Query: 269 ANE-SIRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEK 325
+E RE + ++ L++++ K+ + I K E LK + +E+ ML+++
Sbjct: 234 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET--KTMLEDQ 291
Query: 326 CEALEQLHSQLIIKEQE---MKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEK 381
E +L E+E +KAKL +E E ++ KI E+ E + + + S E
Sbjct: 292 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 351
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC---KDELSTEKFN-FIEEIKTLKD 437
+L E++++ T +L+ L E+N L + K E+ + +EE++T D
Sbjct: 352 L--HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 409
Query: 438 EL---IEKTINYENEKNKLNLAVE----KAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
+ K + E E +L+ VE + ++EK + ++++D++ + ++
Sbjct: 410 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 469
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E Q++ +LE E T+++ + EA V ++ + + E +
Sbjct: 470 LRENSERQIK-------ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 522
Query: 551 IMEHNVTLIE-SLQNVEKEA--YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
++ IE + ++KE Y+E G EL ++ L+KE+ + L++++ ++
Sbjct: 523 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN----ELLQKKITNLKI 578
Query: 608 LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQE 667
CE L Q + S LE EN + +L +L L +E
Sbjct: 579 TCEKIEA---------------LEQ---ENSELERENRKLKKTLDSFKNLTFQLESLEKE 620
Query: 668 NEELTMTVAKQSSIIDKLK---KDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRER 722
N +L + ++ LK + Q Q K ++ LK G E ++ ER
Sbjct: 621 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 678
Score = 68.1 bits (159), Expect = 1e-10
Identities = 95/429 (22%), Positives = 194/429 (45%), Gaps = 24/429 (5%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
E +A+ E++ +Q + E +ED + L EL + Q + E++R
Sbjct: 265 EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERD 324
Query: 164 LSKLRINNT---NCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-EKKCEALDNEVYDKQM 219
+ + +I N E Q D + SR EL E ++L +EV ++
Sbjct: 325 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV--NEL 382
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
S L ++ SL K ++E T+ + + L+M K + L+ + E + E
Sbjct: 383 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV-EILENEIVQ 441
Query: 280 ELEALKTKLDEEKQAIISKCKVDQ--ENLKTKHNASIESLK--NQMLKEKCEALEQ---L 332
E ++L+ + K + K ++++ E L+ I+ L+ N+ L + +L Q +
Sbjct: 442 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI 501
Query: 333 HSQLIIKEQEMKAKL--EQIEESASEKLKICEIQFEERSQSIQ-EHCSQQEKTIQYLEQE 389
++ +K+ E + K+ E I+E++S K+ +I+FE+R + EH ++ + + LE E
Sbjct: 502 SAEARVKDIEKENKILHESIKETSS---KLSKIEFEKRQIKKELEHYKEKGERAEELENE 558
Query: 390 IKELKYTLDLTNNQNSDLKQELNNLKNCKDELST-EKFNFIEEIKTLKDELIEKTINYEN 448
+ L+ +L + ++LK ++ + E S E+ N ++K D T E+
Sbjct: 559 LHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN--RKLKKTLDSFKNLTFQLES 616
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
+ + + E+ ++ + E SL + L L +E +SE EQL+ +++L ++ +
Sbjct: 617 LEKENSQLDEENLELRRNVE-SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 675
Query: 509 LENELTTYK 517
E +Y+
Sbjct: 676 TERLEVSYQ 684
Score = 65.7 bits (153), Expect = 5e-10
Identities = 102/511 (19%), Positives = 236/511 (46%), Gaps = 44/511 (8%)
Query: 73 ATPKAFKITKAPNSSIKKTLTCPKNKILPQDEL--VQAQDVEIRNKDQTICEYNKQIEDY 130
A K ++ + ++ L C + + EL +Q +++ + + ++ Y +++
Sbjct: 181 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 240
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTD 185
+ + ++ ++ E++ ++++ ++I+F + ++ +L+ +N T E + ++GT
Sbjct: 241 REKAVRVDKLESEVS-RYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLE-DQLEGTR 296
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
A S ++++ ++L+ K ++ E D++ +EE +T+ + + + E L
Sbjct: 297 AR--SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 354
Query: 245 N-ELT-LAETQQRLEMVK---GHHALALEANESIRREYKIE-----LEALKTKLDEEKQA 294
EL ++ T + E + GH L ++ ++ E + + +E L+T +D +
Sbjct: 355 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 414
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEE 352
K+++EN + + +E L+N++++EK + + L L+ ++ +++ +E + E
Sbjct: 415 ASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 472
Query: 353 SASEKLKICEIQFE----------ERSQ-SIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ ++KI E + E +RSQ S + EK + L + IKE L
Sbjct: 473 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 532
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+ +K+EL + K K E + E N + ++ + L +K N + K+ A+E+
Sbjct: 533 FEKRQIKKELEHYKE-KGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQEN 590
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL-EDQVQMLTSAKEVLENELTTYKNTL 520
E + L T D LT +L + E QL E+ +++ + + + + + L
Sbjct: 591 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 650
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRI 551
N +E + KE L L+ A K+ R+
Sbjct: 651 EN--KELESEKEQLKKGLELLKASFKKTERL 679
Score = 56.8 bits (131), Expect = 3e-07
Identities = 93/469 (19%), Positives = 207/469 (44%), Gaps = 53/469 (11%)
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA-SIESLKNQM--LKEKCEAL 329
+R+E + + E L E +Q I ++ QEN+ +A S ++++ L+EK +
Sbjct: 188 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 247
Query: 330 EQLHSQLIIKEQEM------KAKLEQIEESASEKLK---ICEIQFE-ERSQSIQEHCSQQ 379
++L S++ ++ + KA++E+++E L+ + E Q E R++S + H +
Sbjct: 248 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH--EL 305
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF---IEEIKTLK 436
EK L+ ++ +++ D+ + +L +E L+ + + E + +E+I
Sbjct: 306 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 365
Query: 437 D--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E +K++ +E N+L + ++ +N+ SL+ T + + + + S++ +
Sbjct: 366 ELSEAPQKSLGHE--VNELTSSRLLKLEMENQ---SLTKTVEELRTTVDSVEGNASKILK 420
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+E + Q L+ E+LENE+ K +L N C + +++K KA L K + E+
Sbjct: 421 MEKENQRLSKKVEILENEIVQEKQSLQN----CQNLSK---DLMKEKAQLEKTIETLREN 473
Query: 555 NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+ I+ L+ + + + +++ E K+ + K L E +++
Sbjct: 474 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE---------- 523
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
S+ L++ + +++ E E Y L EL L +ENE L
Sbjct: 524 ---------TSSK--LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 572
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
+ +K++ +++ + L+K+L K + L + N
Sbjct: 573 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 621
>BC126123-1|AAI26124.1| 1093|Homo sapiens TATA element modulatory
factor 1 protein.
Length = 1093
Score = 72.9 bits (171), Expect = 4e-12
Identities = 97/467 (20%), Positives = 200/467 (42%), Gaps = 48/467 (10%)
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVS 190
K E + + + E + ++ + +R +K I N E A + +E
Sbjct: 490 KEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIK---EELATRLNSSETAD 546
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
++ + +I L ++ E L + Q+ S++ + + +D +++ KL L
Sbjct: 547 -LLKEKDEQIRGLMEEGEKLSKQ----QLHNSNIIKKLRAKDKENENMVAKLNKKVKELE 601
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
E Q L+ V L+ E + ++++ ++ L + ++ +++ + + +VD + L+ K
Sbjct: 602 EELQHLKQV-------LDGKEEVEKQHRENIKKLNSMVERQEKDL-GRLQVDMDELEEK- 652
Query: 311 NASIESLKNQMLKE-----KCEALEQLHSQLIIKEQEMKAK------LEQIEESASEKLK 359
N SI++ + KE K A + +Q +EMKAK LE+ +E A ++ +
Sbjct: 653 NRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQE 712
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
IQ + ++Q + YL EI EL+ L N+N +L Q ++
Sbjct: 713 TLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVS------- 765
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIV 478
ST + + +I+ L+ L +T ++E +EK + ++ + +T L+ +
Sbjct: 766 --STTR-PLLRQIENLQATLGSQTSSWEK--------LEKNLSDRLGESQTLLAAAVERE 814
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
T L + ++ +E Q +L + +L + KN L E + Y+ L N L
Sbjct: 815 RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELEN-L 873
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
K + T E TR + + ++ ++ E R+ E I++ E
Sbjct: 874 KDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKE 920
Score = 64.9 bits (151), Expect = 1e-09
Identities = 97/476 (20%), Positives = 212/476 (44%), Gaps = 28/476 (5%)
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS--RIIE-LEKK 206
+S ++ + D +S IN + A Q AE +++ + +E L +K
Sbjct: 398 RSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEK 457
Query: 207 CEALDNEVYDKQMELSSLEEVI-TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL 265
E + ++ E + LEE ++D + + +E + + L E QR+ + L
Sbjct: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLK-DEFTQRIAEAEKKVQL 516
Query: 266 ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN--LKTKHNASIESLKNQMLK 323
A + ++ ++E K E L T+L+ + A + K K +Q ++ S + L N +
Sbjct: 517 ACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNII 576
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
+K A ++ + ++ K + K++++EE ++ + + EE + +E+ + +
Sbjct: 577 KKLRAKDKENENMVAK---LNKKVKELEEELQHLKQVLDGK-EEVEKQHRENIKKLNSMV 632
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ E+++ L+ +D +N ++ L++ K+ K N ++ E E
Sbjct: 633 ERQEKDLGRLQVDMDELEEKNRSIQAALDSA--YKELTDLHKANAAKD-----SEAQEAA 685
Query: 444 INYE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ-LEDQVQM 501
++ E K +L+ A+EKA +E + + +L++ + + R ++ + E L ++
Sbjct: 686 LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGE 745
Query: 502 LTSAKEVLEN---ELT-TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
L + EN EL+ + +T +R+ + + L + S L K + + + T
Sbjct: 746 LQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQT 805
Query: 558 LIESLQNVEKEAYREL--GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
L+ + E+ A EL I+ +E L ++ NS+ + + E EK R LC++
Sbjct: 806 LLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQ-AQLESEKNR-LCKL 859
Score = 42.3 bits (95), Expect = 0.006
Identities = 97/429 (22%), Positives = 181/429 (42%), Gaps = 40/429 (9%)
Query: 282 EALKTKLDEEKQAIISKC--KVDQENLKTKH-NASIESLKNQMLKEKCEALEQLHSQLII 338
EA L +EK A++ + + E + K ++SI SLK++ + EA +++ QL
Sbjct: 462 EAQLLSLSKEK-ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKV--QLAC 518
Query: 339 KEQEM-KAKLEQIEESASEKLKICEIQ--FEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
KE++ K +++ I+E + +L E +E+ + I+ + EK + +K
Sbjct: 519 KERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIK- 577
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L + +N ++ +LN K K EL E+ ++++ K+E +EK + EN K KLN
Sbjct: 578 KLRAKDKENENMVAKLN--KKVK-ELE-EELQHLKQVLDGKEE-VEKQ-HRENIK-KLNS 630
Query: 456 AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
VE+ K+ + + + + + L DS ++L D L A ++E
Sbjct: 631 MVERQEKDLGRLQVDMDELEEKNRSIQAAL---DSAYKELTD----LHKANAAKDSE--A 681
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR---- 571
+ L+ ++ +E AL + +A +E I ++ L +LQ E+ A R
Sbjct: 682 QEAALSREMKAKEELSAALEKA-QEEARQQQETLAIQVGDLRL--ALQRTEQAAARKEDY 738
Query: 572 ---ELGTIKNELIE----DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXX 624
E+G ++ L E + EL + S++ LR+ + L
Sbjct: 739 LRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSD 798
Query: 625 XSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDK 684
AA + R E S+ + SLLRQEN + + + + K
Sbjct: 799 RLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCK 858
Query: 685 LKKDLEQSQ 693
L+ + + Q
Sbjct: 859 LEDENNRYQ 867
Score = 39.5 bits (88), Expect = 0.041
Identities = 72/350 (20%), Positives = 143/350 (40%), Gaps = 26/350 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEI 160
Q E + Q ++R Q + + EDY ++EI +LQ+ L+E + ++ ++ +
Sbjct: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSV--SST 767
Query: 161 DRKLSKLRINNTNCHTEHNAVQGTDAEK-VSAMINDMRSRIIELEKKCEALDNEVYDKQM 219
R L + +I N EK +S + + ++ + ++ A E+ ++
Sbjct: 768 TRPLLR-QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKI 826
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAET-------QQRLEMVKGHHALALEANES 272
++SS+E ++ Q +L S + L + Q LE +K + LE
Sbjct: 827 QMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK 886
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA--SIESLKNQMLKEKCEALE 330
+ +LE + K+++E++ I QE +K K S+ S ++
Sbjct: 887 EKTLLNSQLEMERMKVEQERKKAI----FTQETIKEKERKPFSVSSTPTMSRSSSISGVD 942
Query: 331 Q--LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
L + + +++ + SA+ ++ S I+ SQ ++ E
Sbjct: 943 MAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQ----LKLREG 998
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-LKD 437
EI L+ + S + +EL L N DEL EK I +++T L+D
Sbjct: 999 EITHLQLEIGNLEKTRSIMAEELVKLTNQNDELE-EKVKEIPKLRTQLRD 1047
>BC117418-1|AAI17419.1| 1093|Homo sapiens TATA element modulatory
factor 1 protein.
Length = 1093
Score = 72.9 bits (171), Expect = 4e-12
Identities = 97/467 (20%), Positives = 200/467 (42%), Gaps = 48/467 (10%)
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVS 190
K E + + + E + ++ + +R +K I N E A + +E
Sbjct: 490 KEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIK---EELATRLNSSETAD 546
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
++ + +I L ++ E L + Q+ S++ + + +D +++ KL L
Sbjct: 547 -LLKEKDEQIRGLMEEGEKLSKQ----QLHNSNIIKKLRAKDKENENMVAKLNKKVKELE 601
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
E Q L+ V L+ E + ++++ ++ L + ++ +++ + + +VD + L+ K
Sbjct: 602 EELQHLKQV-------LDGKEEVEKQHRENIKKLNSMVERQEKDL-GRLQVDMDELEEK- 652
Query: 311 NASIESLKNQMLKE-----KCEALEQLHSQLIIKEQEMKAK------LEQIEESASEKLK 359
N SI++ + KE K A + +Q +EMKAK LE+ +E A ++ +
Sbjct: 653 NRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQE 712
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
IQ + ++Q + YL EI EL+ L N+N +L Q ++
Sbjct: 713 TLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVS------- 765
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIV 478
ST + + +I+ L+ L +T ++E +EK + ++ + +T L+ +
Sbjct: 766 --STTR-PLLRQIENLQATLGSQTSSWEK--------LEKNLSDRLGESQTLLAAAVERE 814
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
T L + ++ +E Q +L + +L + KN L E + Y+ L N L
Sbjct: 815 RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELEN-L 873
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
K + T E TR + + ++ ++ E R+ E I++ E
Sbjct: 874 KDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKE 920
Score = 64.9 bits (151), Expect = 1e-09
Identities = 97/476 (20%), Positives = 212/476 (44%), Gaps = 28/476 (5%)
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS--RIIE-LEKK 206
+S ++ + D +S IN + A Q AE +++ + +E L +K
Sbjct: 398 RSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEK 457
Query: 207 CEALDNEVYDKQMELSSLEEVI-TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL 265
E + ++ E + LEE ++D + + +E + + L E QR+ + L
Sbjct: 458 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLK-DEFTQRIAEAEKKVQL 516
Query: 266 ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN--LKTKHNASIESLKNQMLK 323
A + ++ ++E K E L T+L+ + A + K K +Q ++ S + L N +
Sbjct: 517 ACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNII 576
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
+K A ++ + ++ K + K++++EE ++ + + EE + +E+ + +
Sbjct: 577 KKLRAKDKENENMVAK---LNKKVKELEEELQHLKQVLDGK-EEVEKQHRENIKKLNSMV 632
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ E+++ L+ +D +N ++ L++ K+ K N ++ E E
Sbjct: 633 ERQEKDLGRLQVDMDELEEKNRSIQAALDSA--YKELTDLHKANAAKD-----SEAQEAA 685
Query: 444 INYE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ-LEDQVQM 501
++ E K +L+ A+EKA +E + + +L++ + + R ++ + E L ++
Sbjct: 686 LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGE 745
Query: 502 LTSAKEVLEN---ELT-TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
L + EN EL+ + +T +R+ + + L + S L K + + + T
Sbjct: 746 LQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQT 805
Query: 558 LIESLQNVEKEAYREL--GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
L+ + E+ A EL I+ +E L ++ NS+ + + E EK R LC++
Sbjct: 806 LLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQ-AQLESEKNR-LCKL 859
Score = 42.3 bits (95), Expect = 0.006
Identities = 97/429 (22%), Positives = 181/429 (42%), Gaps = 40/429 (9%)
Query: 282 EALKTKLDEEKQAIISKC--KVDQENLKTKH-NASIESLKNQMLKEKCEALEQLHSQLII 338
EA L +EK A++ + + E + K ++SI SLK++ + EA +++ QL
Sbjct: 462 EAQLLSLSKEK-ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKV--QLAC 518
Query: 339 KEQEM-KAKLEQIEESASEKLKICEIQ--FEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
KE++ K +++ I+E + +L E +E+ + I+ + EK + +K
Sbjct: 519 KERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIK- 577
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L + +N ++ +LN K K EL E+ ++++ K+E +EK + EN K KLN
Sbjct: 578 KLRAKDKENENMVAKLN--KKVK-ELE-EELQHLKQVLDGKEE-VEKQ-HRENIK-KLNS 630
Query: 456 AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
VE+ K+ + + + + + L DS ++L D L A ++E
Sbjct: 631 MVERQEKDLGRLQVDMDELEEKNRSIQAAL---DSAYKELTD----LHKANAAKDSE--A 681
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR---- 571
+ L+ ++ +E AL + +A +E I ++ L +LQ E+ A R
Sbjct: 682 QEAALSREMKAKEELSAALEKA-QEEARQQQETLAIQVGDLRL--ALQRTEQAAARKEDY 738
Query: 572 ---ELGTIKNELIE----DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXX 624
E+G ++ L E + EL + S++ LR+ + L
Sbjct: 739 LRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSD 798
Query: 625 XSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDK 684
AA + R E S+ + SLLRQEN + + + + K
Sbjct: 799 RLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCK 858
Query: 685 LKKDLEQSQ 693
L+ + + Q
Sbjct: 859 LEDENNRYQ 867
Score = 39.5 bits (88), Expect = 0.041
Identities = 72/350 (20%), Positives = 143/350 (40%), Gaps = 26/350 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEI 160
Q E + Q ++R Q + + EDY ++EI +LQ+ L+E + ++ ++ +
Sbjct: 710 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSV--SST 767
Query: 161 DRKLSKLRINNTNCHTEHNAVQGTDAEK-VSAMINDMRSRIIELEKKCEALDNEVYDKQM 219
R L + +I N EK +S + + ++ + ++ A E+ ++
Sbjct: 768 TRPLLR-QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKI 826
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAET-------QQRLEMVKGHHALALEANES 272
++SS+E ++ Q +L S + L + Q LE +K + LE
Sbjct: 827 QMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK 886
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA--SIESLKNQMLKEKCEALE 330
+ +LE + K+++E++ I QE +K K S+ S ++
Sbjct: 887 EKTLLNSQLEMERMKVEQERKKAI----FTQETIKEKERKPFSVSSTPTMSRSSSISGVD 942
Query: 331 Q--LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
L + + +++ + SA+ ++ S I+ SQ ++ E
Sbjct: 943 MAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQ----LKLREG 998
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-LKD 437
EI L+ + S + +EL L N DEL EK I +++T L+D
Sbjct: 999 EITHLQLEIGNLEKTRSIMAEELVKLTNQNDELE-EKVKEIPKLRTQLRD 1047
>AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein.
Length = 1302
Score = 72.9 bits (171), Expect = 4e-12
Identities = 85/423 (20%), Positives = 191/423 (45%), Gaps = 24/423 (5%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
QD+L + D K E IE+ LQ++L +A + R+ + +
Sbjct: 704 QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLL--IAKEGREDL----LRKRE 757
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
R+L+ L+ + H+ E+ A + +R + E K E L + + +
Sbjct: 758 RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQ 817
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
+ E + + + LQ + E +A+ Q+++E +KG A A E + E +
Sbjct: 818 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE 877
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC-------EALEQLHS 334
EAL EEK+A+ ++ ++ E + N S + + + L EK E L +L +
Sbjct: 878 EALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKN 937
Query: 335 QLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
++ + + +E++++ ++ ++ E + E+ + + + +++++KE
Sbjct: 938 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
Query: 395 YTLD---LTNNQNSD----LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ LT + D +++EL + + +DE T++ + +K L+ EL K+ + +
Sbjct: 998 LEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLK 1056
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+++++L +E + ++ E L R+ +L+ R+ S ++EQL + + +A++
Sbjct: 1057 DDRSRLVKQMEAKV---SQLEMELEEERNNSDLLSERISRSREQMEQLRNGLLQERAARQ 1113
Query: 508 VLE 510
LE
Sbjct: 1114 DLE 1116
Score = 57.6 bits (133), Expect = 1e-07
Identities = 81/333 (24%), Positives = 136/333 (40%), Gaps = 22/333 (6%)
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA----LEQLHSQLIIKEQEMKA 345
E K + K K+ E + + +E Q +KE+ E LE+L SQ K +E
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 346 KLEQIEESASEKLKICEIQFE---ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN- 401
+++EES E K E F+ ER Q E Q++ + + E+ K + D
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQ-LSEMHDELDSAKRSEDREKG 726
Query: 402 ---NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVE 458
+ KQ+L +L K+ E+ LK L E+ +++ E +KL E
Sbjct: 727 ALIEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLK---E 783
Query: 459 KAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
+ E S+ V VL R S+ + E +V++L E L+ +
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELER 843
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKN 578
+ R+ ++ K + K+K L K I + L+ + + EKEA ++N
Sbjct: 844 RVAQLQRQIEDLKG---DEAKAKETLKKYEGEIRQLEEALVHA-RKEEKEAVSARRALEN 899
Query: 579 ELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
EL L + + Q + L+EE E+K L
Sbjct: 900 ELEGAQGNLSQTTQEQKQLSEKLKEESEQKEQL 932
Score = 48.8 bits (111), Expect = 7e-05
Identities = 81/397 (20%), Positives = 159/397 (40%), Gaps = 28/397 (7%)
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFE 366
TK ++ K Q LK + Q ++Q E+K LEQ + E ++ ++Q E
Sbjct: 574 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLE 633
Query: 367 -ERSQSIQEHCSQQEKTIQYLEQEIKE-------LKYTLDLTNNQNSDLKQELNNLKNCK 418
+ Q+I+E + ++ L + E L+ L+ + + +EL +K +
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
++ TE + +++ + DEL + + EK L +E+ ++ K + L
Sbjct: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL---IEELLQAKQDLQDLLIAKEGRE 750
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV--- 535
+L R RE + L+++V + L+ + L +V E + E L
Sbjct: 751 DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
N + A T+ ++++ E LQ +E R + ++ + IED++ + ++ +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEE---NEKLQGRSEELERRVAQLQRQ-IEDLKGDEAKAKETL 866
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL---LAQAAADLSRLENENERYXXXXX 652
K E+ R L E R L L A +LS+ E ++
Sbjct: 867 KKYEGEI---RQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLK 923
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDL 689
+L L+ E E + K I+KL+K++
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGK---TIEKLQKEM 957
Score = 47.6 bits (108), Expect = 2e-04
Identities = 76/358 (21%), Positives = 150/358 (41%), Gaps = 30/358 (8%)
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ------EIKELKYTLDLTNNQNSDLKQ 409
EK++ + + +Q + C+ + LEQ E+ EL+ L L ++K+
Sbjct: 583 EKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE 642
Query: 410 ELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET 469
E ++ +EL ++ +EE TL+ L E + +L +E+ + K + E
Sbjct: 643 ERERMRANLEELRSQHNEKVEENSTLQQRL-------EESEGELRKNLEELFQVKMEREQ 695
Query: 470 SLSVTRDIVHVLTLRLRESDSELEQLEDQ-----VQMLTSAKEVLENELTTYKNTLNNTV 524
+ RD+ L+ E DS ++ ED+ ++ L AK+ L+ +L K + +
Sbjct: 696 HQTEIRDLQDQLSEMHDELDS-AKRSEDREKGALIEELLQAKQDLQ-DLLIAKEGREDLL 753
Query: 525 RECDEYKEALVNILKSK-AALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
R+ + AL LK + ++ +E ++ E +++L+ +EA + + + +
Sbjct: 754 RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR-SNT 812
Query: 584 VELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE 643
E + + ++K L+EE EK + E + A+A L + E E
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 644 NERYXXXXXXXXSLVVELSLLRQ--ENE------ELTMTVAKQSSIIDKLKKDLEQSQ 693
+ E R+ ENE L+ T +Q + +KLK++ EQ +
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Score = 42.7 bits (96), Expect = 0.004
Identities = 55/285 (19%), Positives = 139/285 (48%), Gaps = 24/285 (8%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ----EKLTSNELTLAET 252
R + E++++ + E ++ +++ + + + +D Q E LT +L L +T
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQL-LEQT 1041
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
+ LE + + + ++ + ++ L+ +L+EE+ + + E + ++
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEAKVSQLEMELEEER----NNSDLLSERI-SRSRE 1096
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQ--EMKAKLEQIEESASEKLKICEIQFEERSQ 370
+E L+N +L+E+ + ++ ++ Q ++K+++ +E S + +Q E R
Sbjct: 1097 QMEQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIA 1156
Query: 371 SIQEHCSQQEK-------TIQYLEQEIKELKYTLDLTNNQNSDLKQELN-NLKNCKDEL- 421
+++ +E+ + + LE+++KEL +D + +D K +L+ LK K ++
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 422 -STEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAIKEK 464
+ E+ + +E K L+ EL E+ E+ + +LN +++K ++ K
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN-SMKKDLRLK 1260
>AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein.
Length = 742
Score = 72.9 bits (171), Expect = 4e-12
Identities = 112/538 (20%), Positives = 228/538 (42%), Gaps = 58/538 (10%)
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LEMVKGHHALALE 268
L E+ D + ++ L + + + D +++L E+ L QQ + ++ + +
Sbjct: 174 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 233
Query: 269 ANE-SIRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEK 325
+E RE + ++ L++++ K+ + I K E LK + +E+ ML+++
Sbjct: 234 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET--KTMLEDQ 291
Query: 326 CEALEQLHSQLIIKEQE---MKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEK 381
E +L E+E +KAKL +E E ++ KI E+ E + + + S E
Sbjct: 292 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 351
Query: 382 TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC---KDELSTEKFN-FIEEIKTLKD 437
+L E++++ T +L+ L E+N L + K E+ + +EE++T D
Sbjct: 352 L--HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 409
Query: 438 EL---IEKTINYENEKNKLNLAVE----KAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
+ K + E E +L+ VE + ++EK + ++++D++ + ++
Sbjct: 410 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 469
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
E E Q++ +LE E T+++ + EA V ++ + + E +
Sbjct: 470 LRENSERQIK-------ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 522
Query: 551 IMEHNVTLIE-SLQNVEKEA--YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
++ IE + ++KE Y+E G EL ++ L+KE+ + L++++ ++
Sbjct: 523 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN----ELLQKKITNLKI 578
Query: 608 LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQE 667
CE L Q + S LE EN + +L +L L +E
Sbjct: 579 TCEKIEA---------------LEQ---ENSELERENRKLKKTLDSFKNLTFQLESLEKE 620
Query: 668 NEELTMTVAKQSSIIDKLK---KDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRER 722
N +L + ++ LK + Q Q K ++ LK G E ++ ER
Sbjct: 621 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 678
Score = 70.9 bits (166), Expect = 1e-11
Identities = 123/612 (20%), Positives = 257/612 (41%), Gaps = 71/612 (11%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
++ D K +I +L++ L+E + ++ EI+ L +L+ N N ++ + +
Sbjct: 177 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE--LKRLQQENMNLLSDARSARMYR 234
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
E ++ +R + + ++K L++EV + L +E K E+L +
Sbjct: 235 DE-----LDALREKAVRVDK----LESEVSRYKERLHDIE--------FYKARVEELKED 277
Query: 246 ELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKL-DEEKQAIISKCKVDQ 303
L ET+ LE ++G A + + +E + + LK KL D E + + + K+++
Sbjct: 278 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEE 332
Query: 304 ENLKTKHNASIESLKNQMLKEKCEA---LEQLHSQLIIKEQEMKAKLEQIEESASEKLKI 360
+ N ++E + Q + E LEQ+ + E K+ ++ E S +L
Sbjct: 333 ---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 389
Query: 361 CEIQFEERSQSIQEHCSQQEKT------IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E++ + +++++E + + I +E+E + L +++ N+ KQ L N
Sbjct: 390 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 449
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+N +L EK + I+TL++ + E E LN V +++++++ V
Sbjct: 450 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS-SLRQRSQISAEARV- 507
Query: 475 RDIVH---VLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
+DI +L ++E+ S+L ++E + K ++ EL YK +E +
Sbjct: 508 KDIEKENKILHESIKETSSKLSKIEFE-------KRQIKKELEHYKEK----GERAEELE 556
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
L ++ K L K+ T + + IE+L+ E RE +K L +S
Sbjct: 557 NELHHLEKENELLQKKITNL-KITCEKIEALEQENSELERENRKLKKTL---------DS 606
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYX--- 648
+ F E +EK+ + + + +AQ + LE+E E+
Sbjct: 607 FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 666
Query: 649 ----XXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRK 704
L V L EN+ L T+ + I +L+ +L+ + ++ +
Sbjct: 667 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 726
Query: 705 SLKVGKENMQTI 716
LK+ + ++ +
Sbjct: 727 ELKISSKRLEQL 738
Score = 69.3 bits (162), Expect = 4e-11
Identities = 116/571 (20%), Positives = 268/571 (46%), Gaps = 52/571 (9%)
Query: 73 ATPKAFKITKAPNSSIKKTLTCPKNKILPQDEL--VQAQDVEIRNKDQTICEYNKQIEDY 130
A K ++ + ++ L C + + EL +Q +++ + + ++ Y +++
Sbjct: 181 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 240
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN-----TNCHTEHNAVQGTD 185
+ + ++ ++ E++ ++++ ++I+F + ++ +L+ +N T E + ++GT
Sbjct: 241 REKAVRVDKLESEVS-RYKERLHDIEFYKA--RVEELKEDNQVLLETKTMLE-DQLEGTR 296
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEV-YDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
A S ++++ ++L+ K ++ E D++ +EE +T+ + + + E L
Sbjct: 297 AR--SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 354
Query: 245 N-ELT-LAETQQRLEMVK---GHHALALEANESIRREYKIE-----LEALKTKLDEEKQA 294
EL ++ T + E + GH L ++ ++ E + + +E L+T +D +
Sbjct: 355 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 414
Query: 295 IISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEE 352
K+++EN + + +E L+N++++EK + + L L+ ++ +++ +E + E
Sbjct: 415 ASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 472
Query: 353 SASEKLKICEIQFE----------ERSQ-SIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
++ ++KI E + E +RSQ S + EK + L + IKE L
Sbjct: 473 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 532
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAI 461
+ +K+EL + K K E + E N + ++ + L +K N + K+ A+E+
Sbjct: 533 FEKRQIKKELEHYKE-KGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQEN 590
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQL-EDQVQMLTSAKEVLENELTTYKNTL 520
E + L T D LT +L + E QL E+ +++ + + + + + L
Sbjct: 591 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 650
Query: 521 NNTVRECDEYKEALVNILK-SKAALTKEHTRIMEHNVTLIES--LQNVEKEAYRELGTIK 577
N +E + KE L L+ KA+ K + + IE+ LQ + + +++ ++
Sbjct: 651 EN--KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 708
Query: 578 NELIEDVELLKKESNSQIKFLRE-EVEKKRV 607
+EL +D+E+ E+ + K L E ++ KR+
Sbjct: 709 SEL-QDLEM---ENQTLQKNLEELKISSKRL 735
Score = 56.8 bits (131), Expect = 3e-07
Identities = 93/469 (19%), Positives = 207/469 (44%), Gaps = 53/469 (11%)
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA-SIESLKNQM--LKEKCEAL 329
+R+E + + E L E +Q I ++ QEN+ +A S ++++ L+EK +
Sbjct: 188 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 247
Query: 330 EQLHSQLIIKEQEM------KAKLEQIEESASEKLK---ICEIQFE-ERSQSIQEHCSQQ 379
++L S++ ++ + KA++E+++E L+ + E Q E R++S + H +
Sbjct: 248 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH--EL 305
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF---IEEIKTLK 436
EK L+ ++ +++ D+ + +L +E L+ + + E + +E+I
Sbjct: 306 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 365
Query: 437 D--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E +K++ +E N+L + ++ +N+ SL+ T + + + + S++ +
Sbjct: 366 ELSEAPQKSLGHE--VNELTSSRLLKLEMENQ---SLTKTVEELRTTVDSVEGNASKILK 420
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+E + Q L+ E+LENE+ K +L N C + +++K KA L K + E+
Sbjct: 421 MEKENQRLSKKVEILENEIVQEKQSLQN----CQNLSK---DLMKEKAQLEKTIETLREN 473
Query: 555 NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXX 614
+ I+ L+ + + + +++ E K+ + K L E +++
Sbjct: 474 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE---------- 523
Query: 615 XXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
S+ L++ + +++ E E Y L EL L +ENE L
Sbjct: 524 ---------TSSK--LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 572
Query: 675 VAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLRERN 723
+ +K++ +++ + L+K+L K + L + N
Sbjct: 573 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 621
>AB209109-1|BAD92346.1| 1096|Homo sapiens TATA element modulatory
factor 1 variant protein.
Length = 1096
Score = 72.9 bits (171), Expect = 4e-12
Identities = 97/467 (20%), Positives = 200/467 (42%), Gaps = 48/467 (10%)
Query: 131 KNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVS 190
K E + + + E + ++ + +R +K I N E A + +E
Sbjct: 493 KEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIK---EELATRLNSSETAD 549
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
++ + +I L ++ E L + Q+ S++ + + +D +++ KL L
Sbjct: 550 -LLKEKDEQIRGLMEEGEKLSKQ----QLHNSNIIKKLRAKDKENENMVAKLNKKVKELE 604
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
E Q L+ V L+ E + ++++ ++ L + ++ +++ + + +VD + L+ K
Sbjct: 605 EELQHLKQV-------LDGKEEVEKQHRENIKKLNSMVERQEKDL-GRLQVDMDELEEK- 655
Query: 311 NASIESLKNQMLKE-----KCEALEQLHSQLIIKEQEMKAK------LEQIEESASEKLK 359
N SI++ + KE K A + +Q +EMKAK LE+ +E A ++ +
Sbjct: 656 NRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQE 715
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
IQ + ++Q + YL EI EL+ L N+N +L Q ++
Sbjct: 716 TLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVS------- 768
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVTRDIV 478
ST + + +I+ L+ L +T ++E +EK + ++ + +T L+ +
Sbjct: 769 --STTR-PLLRQIENLQATLGSQTSSWEK--------LEKNLSDRLGESQTLLAAAVERE 817
Query: 479 HVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
T L + ++ +E Q +L + +L + KN L E + Y+ L N L
Sbjct: 818 RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELEN-L 876
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVE 585
K + T E TR + + ++ ++ E R+ E I++ E
Sbjct: 877 KDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKE 923
Score = 64.9 bits (151), Expect = 1e-09
Identities = 97/476 (20%), Positives = 212/476 (44%), Gaps = 28/476 (5%)
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS--RIIE-LEKK 206
+S ++ + D +S IN + A Q AE +++ + +E L +K
Sbjct: 401 RSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEK 460
Query: 207 CEALDNEVYDKQMELSSLEEVI-TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHAL 265
E + ++ E + LEE ++D + + +E + + L E QR+ + L
Sbjct: 461 LEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLK-DEFTQRIAEAEKKVQL 519
Query: 266 ALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN--LKTKHNASIESLKNQMLK 323
A + ++ ++E K E L T+L+ + A + K K +Q ++ S + L N +
Sbjct: 520 ACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNII 579
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
+K A ++ + ++ K + K++++EE ++ + + EE + +E+ + +
Sbjct: 580 KKLRAKDKENENMVAK---LNKKVKELEEELQHLKQVLDGK-EEVEKQHRENIKKLNSMV 635
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKT 443
+ E+++ L+ +D +N ++ L++ K+ K N ++ E E
Sbjct: 636 ERQEKDLGRLQVDMDELEEKNRSIQAALDSA--YKELTDLHKANAAKD-----SEAQEAA 688
Query: 444 INYE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ-LEDQVQM 501
++ E K +L+ A+EKA +E + + +L++ + + R ++ + E L ++
Sbjct: 689 LSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGE 748
Query: 502 LTSAKEVLEN---ELT-TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
L + EN EL+ + +T +R+ + + L + S L K + + + T
Sbjct: 749 LQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQT 808
Query: 558 LIESLQNVEKEAYREL--GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
L+ + E+ A EL I+ +E L ++ NS+ + + E EK R LC++
Sbjct: 809 LLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQ-AQLESEKNR-LCKL 862
Score = 42.3 bits (95), Expect = 0.006
Identities = 97/429 (22%), Positives = 181/429 (42%), Gaps = 40/429 (9%)
Query: 282 EALKTKLDEEKQAIISKC--KVDQENLKTKH-NASIESLKNQMLKEKCEALEQLHSQLII 338
EA L +EK A++ + + E + K ++SI SLK++ + EA +++ QL
Sbjct: 465 EAQLLSLSKEK-ALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKV--QLAC 521
Query: 339 KEQEM-KAKLEQIEESASEKLKICEIQ--FEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
KE++ K +++ I+E + +L E +E+ + I+ + EK + +K
Sbjct: 522 KERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIK- 580
Query: 396 TLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L + +N ++ +LN K K EL E+ ++++ K+E +EK + EN K KLN
Sbjct: 581 KLRAKDKENENMVAKLN--KKVK-ELE-EELQHLKQVLDGKEE-VEKQ-HRENIK-KLNS 633
Query: 456 AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
VE+ K+ + + + + + L DS ++L D L A ++E
Sbjct: 634 MVERQEKDLGRLQVDMDELEEKNRSIQAAL---DSAYKELTD----LHKANAAKDSE--A 684
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR---- 571
+ L+ ++ +E AL + +A +E I ++ L +LQ E+ A R
Sbjct: 685 QEAALSREMKAKEELSAALEKA-QEEARQQQETLAIQVGDLRL--ALQRTEQAAARKEDY 741
Query: 572 ---ELGTIKNELIE----DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXX 624
E+G ++ L E + EL + S++ LR+ + L
Sbjct: 742 LRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSD 801
Query: 625 XSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDK 684
AA + R E S+ + SLLRQEN + + + + K
Sbjct: 802 RLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCK 861
Query: 685 LKKDLEQSQ 693
L+ + + Q
Sbjct: 862 LEDENNRYQ 870
Score = 39.5 bits (88), Expect = 0.041
Identities = 72/350 (20%), Positives = 143/350 (40%), Gaps = 26/350 (7%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDY-KNEIAQLQEILKELATKFRQSHNNIDFNEI 160
Q E + Q ++R Q + + EDY ++EI +LQ+ L+E + ++ ++ +
Sbjct: 713 QQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSV--SST 770
Query: 161 DRKLSKLRINNTNCHTEHNAVQGTDAEK-VSAMINDMRSRIIELEKKCEALDNEVYDKQM 219
R L + +I N EK +S + + ++ + ++ A E+ ++
Sbjct: 771 TRPLLR-QIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKI 829
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAET-------QQRLEMVKGHHALALEANES 272
++SS+E ++ Q +L S + L + Q LE +K + LE
Sbjct: 830 QMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRK 889
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA--SIESLKNQMLKEKCEALE 330
+ +LE + K+++E++ I QE +K K S+ S ++
Sbjct: 890 EKTLLNSQLEMERMKVEQERKKAI----FTQETIKEKERKPFSVSSTPTMSRSSSISGVD 945
Query: 331 Q--LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
L + + +++ + SA+ ++ S I+ SQ ++ E
Sbjct: 946 MAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQ----LKLREG 1001
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT-LKD 437
EI L+ + S + +EL L N DEL EK I +++T L+D
Sbjct: 1002 EITHLQLEIGNLEKTRSIMAEELVKLTNQNDELE-EKVKEIPKLRTQLRD 1050
>BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 14
protein.
Length = 980
Score = 72.5 bits (170), Expect = 5e-12
Identities = 107/492 (21%), Positives = 209/492 (42%), Gaps = 36/492 (7%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQS---HNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
K D I QLQEIL++L + S + R+ + +NNT +E+++
Sbjct: 422 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-SENSSD 480
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKC-------EALDNEVYDKQMELSSLEEVITVRDSL 234
++ + + ++ ++K+ E++DN Y EL EE I V L
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN--YSHFHELRVTEEEINV---L 535
Query: 235 CKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
+DLQ L +E + ++ E +V+ ++ E K ++ +++EK
Sbjct: 536 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 595
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
+ K + QE + K +++S Q ++ E +++ +++I + + ++L Q+ +
Sbjct: 596 FLFEKYQEAQEEI-MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE 654
Query: 354 ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
A +L+ + + + H ++ EK +Q + + L +Q S + EL
Sbjct: 655 AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELT 714
Query: 413 NLKNCKDELS------TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
LK D TE I ++T E+ EK N +++ + VE A EK
Sbjct: 715 QLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNL--KEHLASKEVEVAKLEKQL 772
Query: 467 FETSLSVTRDIVHVLTLRLRES--DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
E ++T +V + +S +SE+ L +++ KE + +E+ ++ ++
Sbjct: 773 LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVK 832
Query: 525 RECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIK--NELI 581
RE KE + +LKSK E + + L E + E + E K NE+
Sbjct: 833 RE----KENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKDKKINEMS 888
Query: 582 EDVELLKKESNS 593
++V LK+ NS
Sbjct: 889 KEVTKLKEALNS 900
Score = 58.8 bits (136), Expect = 6e-08
Identities = 104/519 (20%), Positives = 240/519 (46%), Gaps = 50/519 (9%)
Query: 98 KILPQDELVQAQ-DVEIRNKD-QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L E + Q VE++++ + +C N +I + ++++Q LKE +K+ ++ +
Sbjct: 443 KRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK---LKETQSKYEEAMKEV 499
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ KL + + + ++ + ++ T+ E+++ + D+++ + E E+ E + E+
Sbjct: 500 LSVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLKQDLQNALEESERNKEKV-RELE 557
Query: 216 DKQMELSS-------LEEVITVRDSLCKDLQEKLTSNELTLAETQQRL--EMVKGHHALA 266
+K +E +EE ++ S C + E + + L E Q E++K L
Sbjct: 558 EKLVEREKGTVIKPPVEEYEEMKSSYCSVI-ENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAI--ISKC-KVDQENLKT-KHNASIESLKNQML 322
+ + E + EA+ +DE + + +S+ K Q L+ + S+E + + +
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 323 -KEKCEALEQLHSQLIIKEQ----EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K + E L QL + K + EMK++ ++ ++ ++ + Q +E S SI EH
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ-KENSVSITEHL- 734
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
+ I L KE++ + S+LK+ +L + + E++ + +EE + D
Sbjct: 735 ---QVITTLRTAAKEMEEKI-------SNLKE---HLASKEVEVAKLEKQLLEEKAAMTD 781
Query: 438 ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
++ ++ +YE ++ L V +K + S+ ++ VH +++R S++++ ++
Sbjct: 782 AMVPRS-SYEKLQSSLESEVSVLA---SKLKESVK-EKEKVHSEVVQIRSEVSQVKREKE 836
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+Q L +KE NEL + E Y E+ + + K K+ + +
Sbjct: 837 NIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDK---DKKINEMSKEVTK 893
Query: 558 LIESLQNVEKEAYRELGTIK-NELIEDVELLKKESNSQI 595
L E+L ++ + +Y + + ++ +E ++ K+ +Q+
Sbjct: 894 LKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQL 932
>AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain protein.
Length = 1938
Score = 72.5 bits (170), Expect = 5e-12
Identities = 125/647 (19%), Positives = 269/647 (41%), Gaps = 46/647 (7%)
Query: 71 KFATPKAFKITKAPNSSIKKTLT--CPKNKILPQDELVQAQDVEIR-NKDQTICEYNKQI 127
K AT K +++++ ++ + K L + D+++ +K + + N ++
Sbjct: 972 KHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKL 1031
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
E +++ E K+L ++ + E D K+S+ I + E ++ +
Sbjct: 1032 EQQTDDLEGSLEQEKKLRADLERAKRKL---EGDLKMSQESI--MDLENEKQQIE-EKLK 1085
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
K ++ +++RI + + ++ + Q + LEE I +L ++++ +
Sbjct: 1086 KKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLAR 1145
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREY-KIELEALKTKLDEE-KQAIISKCKVDQEN 305
L E +RLE G + +E N+ E+ K+ + + L E A + K + D
Sbjct: 1146 ELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA 1205
Query: 306 LKTKHNASIESLKNQMLKEKCEALEQLHSQL--IIKEQEMKAKLEQIEESASEKLKICEI 363
+ +++ +K ++ KEK E ++ I + K+ +E+ + ++ +
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265
Query: 364 QFEERSQSIQEHCSQQEKTIQ----YLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
+ E+++Q I + + Q+ +Q L ++E + + L Q+L LK +
Sbjct: 1266 KDEQQTQLIHD-LNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME 1324
Query: 420 ELSTEKFNFIEEIKTLKDELIEKTINYENE---KNKLNLAVEKAIKE----KNKFET-SL 471
E + K +++ + + YE E K +L A+ KA E K K+ET ++
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWKTKYETDAI 1384
Query: 472 SVTRDIVHV---LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
T ++ L RL+E++ + E + L K+ L+ E+ L + C
Sbjct: 1385 QRTEELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKN---ELIEDVE 585
+ N K A E + ++ + +E+ Q + EL ++N E+++ +E
Sbjct: 1445 TLDKKQRNFDKVLA----EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLE 1500
Query: 586 LLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENE 645
L++E+ K L+EE+ L E + L+ Q +DL ++ E
Sbjct: 1501 TLRREN----KNLQEEISD---LTEQIAETGKNLQEAEKTKK-LVEQEKSDL-QVALEEV 1551
Query: 646 RYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQS 692
L V+L L Q EL V ++ I++LK++ +++
Sbjct: 1552 EGSLEHEESKILRVQLE-LSQVKSELDRKVIEKDEEIEQLKRNSQRA 1597
Score = 72.1 bits (169), Expect = 6e-12
Identities = 106/510 (20%), Positives = 221/510 (43%), Gaps = 53/510 (10%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAET 252
I+D+ + ++EK+ A +N+V + E+++LEE I+ K LQE +++ TL +
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE---AHQQTLDDL 1014
Query: 253 QQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNA 312
Q + V G ++ N + + + + L+ L++EK K + D E K K
Sbjct: 1015 QVEEDKVNG----LIKINAKLEQ----QTDDLEGSLEQEK-----KLRADLERAKRKLEG 1061
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
+ +M +E LE Q+ K ++ + +L Q++ ++ ++ +QF+++ + +
Sbjct: 1062 DL-----KMSQESIMDLENEKQQIEEKLKKKEFELSQLQARIDDE-QVHSLQFQKKIKEL 1115
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLKNCKDELSTEKFNFIE- 430
Q I+ LE+EI E ++TL Q SDL +EL + +E S IE
Sbjct: 1116 QAR-------IEELEEEI-EAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167
Query: 431 ------EIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
E + ++ +L E T+ +E L ++ E + + + + L
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGE---QIDNLQRVKQKLEKE 1224
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
E E++ + ++ L+ +K +E T ++ + ++ DE + L++ L + A
Sbjct: 1225 KSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE-IKAKDEQQTQLIHDLNMQKAR 1283
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIK---FLREE 601
+ + H V ESL +L K L + +E LK++ + K +
Sbjct: 1284 LQTQNGELSHRVEEKESL-------ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHA 1336
Query: 602 VEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENER-YXXXXXXXXSLVVE 660
++ R C++ + L++A +++++ + + E +
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWKTKYETDAIQRTEELEEAKKK 1396
Query: 661 LSLLRQENEELTMTVAKQSSIIDKLKKDLE 690
L+ QE EE T T + + ++K K+ L+
Sbjct: 1397 LAQRLQEAEEKTETANSKCASLEKTKQRLQ 1426
Score = 63.7 bits (148), Expect = 2e-09
Identities = 112/497 (22%), Positives = 220/497 (44%), Gaps = 39/497 (7%)
Query: 136 QLQEILKELATKFRQSHN---NIDFNE--IDRKLSKLRINNTNCHTEHNAVQGTDAEKVS 190
+LQ +++L +SH +D + D+ L++ + E A Q ++ +S
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ-KESRSLS 1482
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
+ MR+ E+ + E L E + Q E+S L E I ++ ++ E +
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS 1542
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDE---EKQAIISKCKVDQ---- 303
+ Q LE V+G +LE ES ++EL +K++LD EK I + K +
Sbjct: 1543 DLQVALEEVEG----SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAA 1598
Query: 304 ENLKTKHNASIESLKNQM-LKEKCEA-LEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
E L++ +A I S + + LK+K E L ++ QL ++M A+ ++ + +LK
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQM-AETQRHLRTVQGQLKDS 1657
Query: 362 EIQFEERSQS---IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
++ ++ +S ++E + E+ L +E++E+K L+ T +QEL + +
Sbjct: 1658 QLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV 1717
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYEN---EKNKLNLAVEKAIKEKNKFETSLSVTR 475
L ++ + I K L+ ++ + EN E +KAI + L +
Sbjct: 1718 QLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 476 DI-VHVLTLR--LRESDSELEQLEDQVQMLT---SAKEV--LENELTTYKNTLNNTVREC 527
D H+ ++ L ++ +L+ D+ + L K++ LEN + +N L+ E
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD---VEQ 1834
Query: 528 DEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELL 587
EAL K + + KE T E + I LQ++ + ++ + K + E+ E
Sbjct: 1835 KRGAEALKGAHKYERKV-KEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQ-AEEAEEQ 1892
Query: 588 KKESNSQIKFLREEVEK 604
S+ + ++ E+E+
Sbjct: 1893 ANTQLSRCRRVQHELEE 1909
Score = 59.7 bits (138), Expect = 4e-08
Identities = 95/427 (22%), Positives = 185/427 (43%), Gaps = 40/427 (9%)
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
EA + +L+E+ +++ ++ +L+ + + E+L + +E+CE L + L K +
Sbjct: 871 EARRKELEEKMVSLLQ----EKNDLQLQVQSETENLMDA--EERCEGLIKSKILLEAKVK 924
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
E+ +LE+ EE SE + + +++++ CS ++ I LE + +++ T
Sbjct: 925 ELTERLEEEEEMNSELVA--------KKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATE 976
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKA 460
N+ +L +E+ L+ +L+ EK + E +TL D +E+ + N K+N +E
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE--DKVNGLIKINAKLE-- 1032
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
++ + E SL + + L R+ + +L+ ++ + L + K+ +E +L + L
Sbjct: 1033 -QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKKKEFEL 1091
Query: 521 NN-TVRECDEYKEAL--VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK 577
+ R DE +L +K A +E +E TL ++ + REL I
Sbjct: 1092 SQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEIS 1151
Query: 578 NELIE-------DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
L E +E+ KK ++ + +R ++E+ + E S L
Sbjct: 1152 ERLEEASGATSAQIEMNKKR-EAEFQKMRRDLEEATLQHE---ATAATLRKKQADSVAEL 1207
Query: 631 AQAAADLSR----LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLK 686
+ +L R LE E S + LS + E TV Q S I
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK--A 1265
Query: 687 KDLEQSQ 693
KD +Q+Q
Sbjct: 1266 KDEQQTQ 1272
Score = 49.2 bits (112), Expect = 5e-05
Identities = 103/535 (19%), Positives = 226/535 (42%), Gaps = 46/535 (8%)
Query: 90 KTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFR 149
+ L+ K+ I V+ Q EI+ KD+ + + I D + A+LQ EL+ +
Sbjct: 1240 EALSKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 150 QSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEA 209
+ + I +L+K + T E + + +AM + ++S C+
Sbjct: 1297 EKESLIS------QLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSS----RHDCDL 1346
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA 269
L + ++Q + L+ ++ +S ++ + T E + + LE K A L+
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANS---EVAQWKTKYETDAIQRTEELEEAKKKLAQRLQE 1403
Query: 270 NESIRREYKIELEALK-TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ-----MLK 323
E K E K L++ KQ + + + +L+ H A K Q +L
Sbjct: 1404 AEE-----KTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLA 1458
Query: 324 EKCEALEQLHSQLIIKEQEMKA---KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQE 380
E + L++ ++L ++E ++ +L ++ + E + E E ++++QE S
Sbjct: 1459 EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRE-NKNLQEEISDLT 1517
Query: 381 KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI 440
+ I + ++E + T L + SDL+ L ++ + ++ E+ +K EL
Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELD 1577
Query: 441 EKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRES-DSELEQLEDQ 498
K I + E +L ++A + ++ + + D LRL++ + +L ++E Q
Sbjct: 1578 RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND-----ALRLKKKMEGDLNEMEIQ 1632
Query: 499 VQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTL 558
+ + L T + L ++ D+ + ++ + A + + + ++E +
Sbjct: 1633 LGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Query: 559 IESLQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKKRVLCE 610
+L+ E+ R L + EL+ + V+LL ++ S I ++++E C+
Sbjct: 1693 KVALEQTERT--RRLS--EQELLDASDRVQLLHSQNTSLIN-TKKKLEADIAQCQ 1742
>AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein.
Length = 989
Score = 72.5 bits (170), Expect = 5e-12
Identities = 107/492 (21%), Positives = 209/492 (42%), Gaps = 36/492 (7%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQS---HNNIDFNEIDRKLSKLRINNTNCHTEHNAV 181
K D I QLQEIL++L + S + R+ + +NNT +E+++
Sbjct: 431 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-SENSSD 489
Query: 182 QGTDAEKVSAMINDMRSRIIELEKKC-------EALDNEVYDKQMELSSLEEVITVRDSL 234
++ + + ++ ++K+ E++DN Y EL EE I V L
Sbjct: 490 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN--YSHFHELRVTEEEINV---L 544
Query: 235 CKDLQEKLTSNELTLAETQQRLE-MVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
+DLQ L +E + ++ E +V+ ++ E K ++ +++EK
Sbjct: 545 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 604
Query: 294 AIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEES 353
+ K + QE + K +++S Q ++ E +++ +++I + + ++L Q+ +
Sbjct: 605 FLFEKYQEAQEEI-MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKE 663
Query: 354 ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
A +L+ + + + H ++ EK +Q + + L +Q S + EL
Sbjct: 664 AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELT 723
Query: 413 NLKNCKDELS------TEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
LK D TE I ++T E+ EK N +++ + VE A EK
Sbjct: 724 QLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNL--KEHLASKEVEVAKLEKQL 781
Query: 467 FETSLSVTRDIVHVLTLRLRES--DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
E ++T +V + +S +SE+ L +++ KE + +E+ ++ ++
Sbjct: 782 LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVK 841
Query: 525 RECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIK--NELI 581
RE KE + +LKSK E + + L E + E + E K NE+
Sbjct: 842 RE----KENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKDKKINEMS 897
Query: 582 EDVELLKKESNS 593
++V LK+ NS
Sbjct: 898 KEVTKLKEALNS 909
Score = 58.8 bits (136), Expect = 6e-08
Identities = 104/519 (20%), Positives = 240/519 (46%), Gaps = 50/519 (9%)
Query: 98 KILPQDELVQAQ-DVEIRNKD-QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K L E + Q VE++++ + +C N +I + ++++Q LKE +K+ ++ +
Sbjct: 452 KRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQK---LKETQSKYEEAMKEV 508
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVY 215
+ KL + + + ++ + ++ T+ E+++ + D+++ + E E+ E + E+
Sbjct: 509 LSVQKQMKLGLVSPESMDNYSHFHELRVTE-EEINVLKQDLQNALEESERNKEKV-RELE 566
Query: 216 DKQMELSS-------LEEVITVRDSLCKDLQEKLTSNELTLAETQQRL--EMVKGHHALA 266
+K +E +EE ++ S C + E + + L E Q E++K L
Sbjct: 567 EKLVEREKGTVIKPPVEEYEEMKSSYCSVI-ENMNKEKAFLFEKYQEAQEEIMKLKDTLK 625
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAI--ISKC-KVDQENLKT-KHNASIESLKNQML 322
+ + E + EA+ +DE + + +S+ K Q L+ + S+E + + +
Sbjct: 626 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 685
Query: 323 -KEKCEALEQLHSQLIIKEQ----EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCS 377
K + E L QL + K + EMK++ ++ ++ ++ + Q +E S SI EH
Sbjct: 686 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ-KENSVSITEHL- 743
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
+ I L KE++ + S+LK+ +L + + E++ + +EE + D
Sbjct: 744 ---QVITTLRTAAKEMEEKI-------SNLKE---HLASKEVEVAKLEKQLLEEKAAMTD 790
Query: 438 ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLED 497
++ ++ +YE ++ L V +K + S+ ++ VH +++R S++++ ++
Sbjct: 791 AMVPRS-SYEKLQSSLESEVSVLA---SKLKESVK-EKEKVHSEVVQIRSEVSQVKREKE 845
Query: 498 QVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVT 557
+Q L +KE NEL + E Y E+ + + K K+ + +
Sbjct: 846 NIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDK---DKKINEMSKEVTK 902
Query: 558 LIESLQNVEKEAYRELGTIK-NELIEDVELLKKESNSQI 595
L E+L ++ + +Y + + ++ +E ++ K+ +Q+
Sbjct: 903 LKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQL 941
>Z54367-1|CAA91196.1| 4684|Homo sapiens plectin protein.
Length = 4684
Score = 72.1 bits (169), Expect = 6e-12
Identities = 106/509 (20%), Positives = 207/509 (40%), Gaps = 31/509 (6%)
Query: 191 AMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
A + + R + + + E E ++Q+E L+ +R L +E L L A
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEA-ERQLERWQLKANEALRLRL--QAEEVLQQKSLAQA 1797
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
E +++ E + +A E R+ ++ + L+ + + + +QE ++ +
Sbjct: 1798 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
+ Q+L+E+ L++ + K QE++A+L ++ + E L + + EE S+
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLASKAKAEEESR 1916
Query: 371 SIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF 426
S E Q+ + + L +E L+ + Q +++ + + + EK
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 427 NFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
I E LK E+ K ENE+ + LA ++A + + E + DI L
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
+ SDSELE+ + V+ + +E E+ K + E + L I +S A
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAED 2094
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
T E L E+ RE E ++ ++E+ Q K EEVE+
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 605 KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLL 664
+ E ++ LAQ AA RL+ E + + +
Sbjct: 2151 LKAKVE-EARSLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-------------V 2195
Query: 665 RQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
+Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2196 QQKEQELQQTLQQEQSVLDRLRGEAEAAR 2224
Score = 63.3 bits (147), Expect = 3e-09
Identities = 125/606 (20%), Positives = 256/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1959 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 2018
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 2019 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 2072
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 2073 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 2128
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E ++ E+ E+ ++ +L++ +
Sbjct: 2129 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARSLRERAEQESARQLQLAQE 2178
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDRLRGEAEAARRAAEEAEEARVQAE 2238
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2239 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2290
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2346
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2347 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2402
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2463 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 717 SPLRER 722
S ER
Sbjct: 2516 SAEAER 2521
Score = 61.3 bits (142), Expect = 1e-08
Identities = 126/634 (19%), Positives = 266/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 2085
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 225 EEVITVRDSL--CKDLQEKL---TSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + + L+E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2146 EEVERLKAKVEEARSLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2206 LQQEQSV-LDRLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2262
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2374
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2375 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2427 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2476
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2477 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2530
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2531 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2616
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2407
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2468 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2646
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2707 QEELQQLEQQ 2716
Score = 56.8 bits (131), Expect = 3e-07
Identities = 79/384 (20%), Positives = 170/384 (44%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1441 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E + ++ IQ E+ ++ + +D Q +
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAERE-AKELQQRIQ--EEVVRREEAAVD-AQQQKRSI 1555
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1556 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A +E + +L+ ++ A EL + + E
Sbjct: 1667 EKQRALQALEELRLQAEEAERWLCQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERR 1750
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2328
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2560
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2713
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2565
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2625
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2626 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2676
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2737 LLEEQHRAALAHSEEVTASQVAATKTL 2763
>U93121-1|AAB88727.1| 753|Homo sapiens M-phase phosphoprotein-1
protein.
Length = 753
Score = 72.1 bits (169), Expect = 6e-12
Identities = 99/441 (22%), Positives = 210/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K +SH+ ++ + ++++
Sbjct: 70 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVERSHSAKLEQDILEKES 125
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 126 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 185
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 186 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 244
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 245 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 299
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 300 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 347
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 348 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 406
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 407 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 461
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 462 LEIQLKALISSNVQKDNEIEQ 482
Score = 45.2 bits (102), Expect = 8e-04
Identities = 55/232 (23%), Positives = 119/232 (51%), Gaps = 25/232 (10%)
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
S++ I+ LEQ+I++L+ + ++N+ LK++ + KN +D+L EK I++ LK
Sbjct: 5 SKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEH--KN-QDDLLKEKETLIQQ---LK 58
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
+EL EK + L++ ++ ++ K +LS V +++E ++ LE
Sbjct: 59 EELQEKNVT-------LDVQIQHVVEGKR----ALSELTQGVTCYKAKIKELETILE--T 105
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+V+ SAK LE ++ ++ + R E++E L + +K+ L + ++ E
Sbjct: 106 QKVERSHSAK--LEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT 163
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKE---SNSQIKFLREEVEKK 605
L +LQ++ K + + ++ E LK+E S+++ + L+ ++++K
Sbjct: 164 QLTNNLQDM-KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRK 214
Score = 42.7 bits (96), Expect = 0.004
Identities = 53/294 (18%), Positives = 127/294 (43%), Gaps = 14/294 (4%)
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH 375
S K+ ++E + +E+L +++ + E E+ ++ + LK + E Q ++E
Sbjct: 5 SKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLK----EKETLIQQLKEE 60
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTL 435
++ T+ Q + E K L + K ++ L+ L T+K K
Sbjct: 61 LQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETI---LETQKVERSHSAKLE 117
Query: 436 KDELIEKTINYENEKN--KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+D L +++I + E+N + ++ ++K ++ + LT L++ L+
Sbjct: 118 QDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQ 177
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
E++ + E L+ EL+ N + +E + LK K K+ + ++
Sbjct: 178 LKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYAD-LKEKLTDAKKQIKQVQ 236
Query: 554 HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
V+++ + + EL KN+ +++++ ++ I+ L+E++ ++V
Sbjct: 237 KEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR----TIQQLKEQLNNQKV 286
Score = 37.1 bits (82), Expect = 0.22
Identities = 55/282 (19%), Positives = 123/282 (43%), Gaps = 20/282 (7%)
Query: 422 STEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
S++K + IEE++ ++L + Y++E N+L K + KN+ + L ++ L
Sbjct: 4 SSKKSHQIEELEQQIEKLQAEVKGYKDENNRL-----KEKEHKNQ-DDLLKEKETLIQQL 57
Query: 482 TLRLRESDSELE-QLEDQVQMLTSAKEVLENELTTYKNTLN--NTVRECDEYKEA----- 533
L+E + L+ Q++ V+ + E+ + +T YK + T+ E + + +
Sbjct: 58 KEELQEKNVTLDVQIQHVVEGKRALSELTQG-VTCYKAKIKELETILETQKVERSHSAKL 116
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNS 593
+IL+ ++ + K + E L +S++N + +EL +K E+ + L ++
Sbjct: 117 EQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKEL-KLKEEITQLTNNL-QDMKH 174
Query: 594 QIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXX 653
++ EE E R E + L + D + L+ E+
Sbjct: 175 LLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLK---EKLTDAKKQ 231
Query: 654 XXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYT 695
+ E+S++R E++ L + + + ++ ++L+ Q T
Sbjct: 232 IKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRT 273
Score = 31.9 bits (69), Expect = 8.3
Identities = 46/201 (22%), Positives = 88/201 (43%), Gaps = 12/201 (5%)
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
+S ++ L+ ++L E + +E LK++ + + EK L +++ ++E
Sbjct: 4 SSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQE 63
Query: 464 KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNT 523
KN +L V I HV+ E L +L V + + LE L T K +++
Sbjct: 64 KN---VTLDV--QIQHVV-----EGKRALSELTQGVTCYKAKIKELETILETQKVERSHS 113
Query: 524 VRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
+ + E ILK + L KE ++ +V + L E + E+ + N L +D
Sbjct: 114 AKLEQDILEKESIILKLERNL-KEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNL-QD 171
Query: 584 VELLKKESNSQIKFLREEVEK 604
++ L + + + R+E EK
Sbjct: 172 MKHLLQLKEEEEETNRQETEK 192
>AY739715-1|AAW65984.1| 617|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 617
Score = 72.1 bits (169), Expect = 6e-12
Identities = 99/441 (22%), Positives = 210/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K +SH+ ++ + ++++
Sbjct: 32 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVERSHSAKLEQDILEKES 87
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 88 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 147
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 148 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 206
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 207 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 261
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 262 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 309
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 310 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 368
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 369 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 423
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 424 LEIQLKALISSNVQKDNEIEQ 444
Score = 49.6 bits (113), Expect = 4e-05
Identities = 71/301 (23%), Positives = 139/301 (46%), Gaps = 40/301 (13%)
Query: 318 KNQ--MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE---SASE----------KLK--- 359
KNQ +LKEK ++QL +L K + +++ + E + SE K+K
Sbjct: 3 KNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE 62
Query: 360 -ICEIQFEERSQS--IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
I E Q ERS S +++ ++E I LE+ +KE + L + DL + LK
Sbjct: 63 TILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKE 122
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD 476
+L T ++ + LK+E E+T E EK K L+ A + L +
Sbjct: 123 EITQL-TNNLQDMKHLLQLKEE-EEETNRQETEKLKEELSASSA--RTQNLKADLQRKEE 178
Query: 477 IVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVN 536
L +L ++ +++Q++ +V ++ ++L ++ + N +E D K+ +
Sbjct: 179 DYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD-MKQRTIQ 237
Query: 537 ILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVEL-LKKESNSQI 595
LK + +N + E++Q E+ A ++L +K ++IED+ + L+++ +Q+
Sbjct: 238 QLKEQL-----------NNQKVEEAIQQYER-ACKDL-NVKEKIIEDMRMTLEEQEQTQV 284
Query: 596 K 596
+
Sbjct: 285 E 285
>AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1116
Score = 72.1 bits (169), Expect = 6e-12
Identities = 99/441 (22%), Positives = 210/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K +SH+ ++ + ++++
Sbjct: 433 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVERSHSAKLEQDILEKES 488
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 489 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 548
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 549 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 607
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 608 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 662
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 663 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 710
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 711 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 769
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 770 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 824
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 825 LEIQLKALISSNVQKDNEIEQ 845
Score = 68.1 bits (159), Expect = 1e-10
Identities = 109/515 (21%), Positives = 237/515 (46%), Gaps = 51/515 (9%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRI 169
E++N+ + E NKQI ++ E++ ++ L+ + +Q +N D E+ + SK +
Sbjct: 193 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 252
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI- 228
N ++ T ++ ++ ++ +++ + LD+ ++L +L ++
Sbjct: 253 QEEKIMKLSNEIE-TATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSN 310
Query: 229 -TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-ESIRREYK--IELEAL 284
+ D+L + Q L N+ +++ + + + + + ++ E+I E K ++ +
Sbjct: 311 GSEEDNL-PNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 369
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQ--MLKEKCEALEQLHSQLIIKEQ 341
K+ EE + I K + + + K ++N E KNQ +LKEK ++QL +L K
Sbjct: 370 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 429
Query: 342 EMKAKLEQIEE---SASE----------KLK----ICEIQFEERSQS--IQEHCSQQEKT 382
+ +++ + E + SE K+K I E Q ERS S +++ ++E
Sbjct: 430 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVERSHSAKLEQDILEKESI 489
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
I LE+ +KE + L + DL + LK +L T ++ + LK+E E+
Sbjct: 490 ILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQL-TNNLQDMKHLLQLKEE-EEE 547
Query: 443 TINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQML 502
T E EK K L+ A + L + L +L ++ +++Q++ +V ++
Sbjct: 548 TNRQETEKLKEELSASSA--RTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVM 605
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
++L ++ + N +E D K+ + LK + +N + E++
Sbjct: 606 RDEDKLLRIKINELEKKKNQCSQELD-MKQRTIQQLKEQL-----------NNQKVEEAI 653
Query: 563 QNVEKEAYRELGTIKNELIEDVEL-LKKESNSQIK 596
Q E+ A ++L +K ++IED+ + L+++ +Q++
Sbjct: 654 QQYER-ACKDL-NVKEKIIEDMRMTLEEQEQTQVE 686
>AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related
protein protein.
Length = 1820
Score = 72.1 bits (169), Expect = 6e-12
Identities = 99/441 (22%), Positives = 210/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K +SH+ ++ + ++++
Sbjct: 1137 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVERSHSAKLEQDILEKES 1192
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 1193 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1252
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 1253 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 1311
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 1312 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1366
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 1367 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 1414
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 1415 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 1473
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 1474 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 1528
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 1529 LEIQLKALISSNVQKDNEIEQ 1549
Score = 68.1 bits (159), Expect = 1e-10
Identities = 109/515 (21%), Positives = 237/515 (46%), Gaps = 51/515 (9%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRI 169
E++N+ + E NKQI ++ E++ ++ L+ + +Q +N D E+ + SK +
Sbjct: 897 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 956
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI- 228
N ++ T ++ ++ ++ +++ + LD+ ++L +L ++
Sbjct: 957 QEEKIMKLSNEIE-TATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSN 1014
Query: 229 -TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-ESIRREYK--IELEAL 284
+ D+L + Q L N+ +++ + + + + + ++ E+I E K ++ +
Sbjct: 1015 GSEEDNL-PNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1073
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQ--MLKEKCEALEQLHSQLIIKEQ 341
K+ EE + I K + + + K ++N E KNQ +LKEK ++QL +L K
Sbjct: 1074 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 1133
Query: 342 EMKAKLEQIEE---SASE----------KLK----ICEIQFEERSQS--IQEHCSQQEKT 382
+ +++ + E + SE K+K I E Q ERS S +++ ++E
Sbjct: 1134 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVERSHSAKLEQDILEKESI 1193
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
I LE+ +KE + L + DL + LK +L T ++ + LK+E E+
Sbjct: 1194 ILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQL-TNNLQDMKHLLQLKEE-EEE 1251
Query: 443 TINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQML 502
T E EK K L+ A + L + L +L ++ +++Q++ +V ++
Sbjct: 1252 TNRQETEKLKEELSASSA--RTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVM 1309
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
++L ++ + N +E D K+ + LK + +N + E++
Sbjct: 1310 RDEDKLLRIKINELEKKKNQCSQELD-MKQRTIQQLKEQL-----------NNQKVEEAI 1357
Query: 563 QNVEKEAYRELGTIKNELIEDVEL-LKKESNSQIK 596
Q E+ A ++L +K ++IED+ + L+++ +Q++
Sbjct: 1358 QQYER-ACKDL-NVKEKIIEDMRMTLEEQEQTQVE 1390
Score = 35.1 bits (77), Expect = 0.89
Identities = 81/418 (19%), Positives = 177/418 (42%), Gaps = 25/418 (5%)
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITV-RDSLCKDLQEKLTSNELTLAETQQRLE 257
R ++ + + E L E + L +L + I V ++S Q+ + E L Q
Sbjct: 386 RTVKTQNEGERL-RETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFF 444
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL----KTKHNAS 313
KG + + ++ Y L LK +K + QE L K+ + S
Sbjct: 445 NGKGKICMIVNISQCYLA-YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVS 503
Query: 314 IESLKNQMLKEKCEALEQLHSQL--IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQS 371
++S N + A + L +++++++ +LE EE+ + + K+ + E+ ++
Sbjct: 504 LDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLD---EDLDKT 560
Query: 372 IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF-IE 430
++E+ K E++ K L DL ++ K++L ++E++ E + +
Sbjct: 561 LEEN-----KAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQ 615
Query: 431 EIKTLKDELI-EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLRES 488
K+ L+ E+ I EN + +L + + K + E + + V T
Sbjct: 616 READFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGF 675
Query: 489 DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL--TK 546
+ ++ L+D V + E+ + + + T ++ + + K+K L TK
Sbjct: 676 EDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTK 735
Query: 547 EHTRIMEH-NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
E + E+ + +LI+ L+ K+ + IK ELI ++ K+++ ++ + L+ +E
Sbjct: 736 EELKKRENESDSLIQELKTSIKKIITQNQRIK-ELINIID-QKEDTINEFQNLKSLME 791
>BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/CAST
family member 2 protein.
Length = 957
Score = 71.7 bits (168), Expect = 8e-12
Identities = 119/547 (21%), Positives = 236/547 (43%), Gaps = 38/547 (6%)
Query: 201 IEL-EKKCEALDNEVYDKQM-ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
IEL E+ L E +D+Q EL L + + + + ++ L + + ++ + + L+
Sbjct: 256 IELTEENFRRLQAE-HDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 314
Query: 259 VKGHHALALEA-NESIRR--EYKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASI 314
KG + +LE NE RR E + ++ L+ LD+ EK+ I + ++ + + A
Sbjct: 315 -KGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKT 373
Query: 315 ESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
++L+ +M K +LE+ L + Q +KA E E++K E+ ++ S+ +
Sbjct: 374 KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV-YKSHSKFM 432
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEI 432
+ Q ++ + E E+ L+ L+ +NQNSD KQ + LK E+
Sbjct: 433 KTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 492
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
L+ L EK ++ N+K K ++ +EK + +D++ V ++ ++
Sbjct: 493 DALRLRLEEKE-SFLNKKTK---QLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI 548
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
E L++Q++ L++ + + + +NT +EAL + L ++ R
Sbjct: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD 608
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIED----VELLKKES---------NSQIKFLR 599
+ IES + K+ ++ ++ EL E ++L + S +S++K L
Sbjct: 609 RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLE 668
Query: 600 EEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVV 659
+E+K+ C SR + + A + +L+ E Y + V
Sbjct: 669 IAIEQKKEECSKLEAQLKKAHNIEDDSR-MNPEFADQIKQLDKEASYYRDECGKAQAEVD 727
Query: 660 E-LSLLRQ-ENE--ELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQT 715
L +L++ ENE + +A+ S+ + KD + K L K K+N Q
Sbjct: 728 RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK-----KKNAQL 782
Query: 716 ISPLRER 722
+ +R R
Sbjct: 783 LEEVRRR 789
Score = 71.3 bits (167), Expect = 1e-11
Identities = 109/502 (21%), Positives = 207/502 (41%), Gaps = 42/502 (8%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+Q+ D + + LQ LKEL Q N++ E+D K SKL + + T
Sbjct: 140 RQVRD--STMLDLQAQLKEL-----QRENDLLRKELDIKDSKLGSSMNSIKT----FWSP 188
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+ +K + + +R+ L+++ E Q+ + +L++ + + L LQ++ +
Sbjct: 189 ELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN 248
Query: 245 N---ELTLAETQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISK 298
T+ T++ ++ H + +R+ E ++ +E K L+ ++I K
Sbjct: 249 RGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESI--K 306
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
++ K + S+E N+ + EA Q+ +I +Q+ K + EE
Sbjct: 307 KLLEMLQSKGLPSKSLED-DNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQ 365
Query: 359 KICEIQFEERSQSIQE----HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E + Q++ E + E+ I+ LE EI+ LK L + +++
Sbjct: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNLAVEKAIKEKNKFETSL 471
K+ + T+ +E+ + EL+ E N+ + +E + E
Sbjct: 426 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA 485
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
++ + V L LRL E +S L + Q+Q LT K L E+ K+ L E K
Sbjct: 486 AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDML--------EVK 537
Query: 532 EALVNILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEAYRELGTIKNELIED---V 584
E +N+L+ K +E R + +T ++SLQ L T++ L E +
Sbjct: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERII 597
Query: 585 ELLKKESNSQIKFLREEVEKKR 606
E LK++ + EE+E R
Sbjct: 598 ERLKEQRERDDRERLEEIESFR 619
Score = 48.8 bits (111), Expect = 7e-05
Identities = 73/390 (18%), Positives = 170/390 (43%), Gaps = 20/390 (5%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
+I ++++ ++ +I + I +Q+ D ++ L++ +K L T S+ +
Sbjct: 526 EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTD--SSNTDTAL 583
Query: 158 NEIDRKLSKLR--INNTNCHTEHNAVQGTDA-EKVSAMINDMRSRIIELEKKCEALDNEV 214
++ LS+ I E + + + E D++ ++ L+ + ++ +
Sbjct: 584 ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIR 274
D + SSL RDS K L+ + + ++ + +L+ K H+ +E + +
Sbjct: 644 IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK--KAHN---IEDDSRMN 698
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
E+ +++ +LD+E +C Q + + ++ ++N+ +K + + +L S
Sbjct: 699 PEFADQIK----QLDKEASYYRDECGKAQAEV-DRLLEILKEVENEK-NDKDKKIAELES 752
Query: 335 QLIIKEQEMKAKLEQIEESAS-EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
+ ++ K+ ++ + EK K ++ E R + + Q I+ L +++
Sbjct: 753 LTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 812
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ LD T + + +Q L + L E+ +EEI +K E + I+ E + N
Sbjct: 813 RQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS-EKDANIA 871
Query: 454 NLAVEKAIKEKNKFET-SLSVTRD-IVHVL 481
L + + K+K + E +L +D +VH L
Sbjct: 872 LLELSASKKKKTQEEVMALKREKDRLVHQL 901
Score = 41.5 bits (93), Expect = 0.010
Identities = 71/336 (21%), Positives = 137/336 (40%), Gaps = 25/336 (7%)
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
HH +R ++L+A +L E + + + L + N+ ++
Sbjct: 131 HHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPEL 190
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
KE+ E+ ++KEQ M+ EE+ +L I +Q E R+Q H QQE
Sbjct: 191 KKERVLRKEEAARMSVLKEQ-MRV---SHEENQHLQLTIQALQDELRTQRDLNHLLQQES 246
Query: 382 --------TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE-I 432
TI+ E+ + L+ D + L++ L ++ + E + N +E I
Sbjct: 247 GNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQTLNARDESI 305
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
K L + L K + ++ ++ + + E + L V D + LRE
Sbjct: 306 KKLLEMLQSKGLPSKSLEDDNERT--RRMAEAESQVSHLEVILDQKEKENIHLREELHRR 363
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
QL+ + + + V+E + T +L +R+ ++ + +LK+ L +T
Sbjct: 364 SQLQPEPAKTKALQTVIEMKDTKIA-SLERNIRDLEDE----IQMLKANGVL---NTEDR 415
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELI-EDVELL 587
E + IE ++ K ++ +K EL ++ ELL
Sbjct: 416 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELL 451
Score = 36.7 bits (81), Expect = 0.29
Identities = 34/134 (25%), Positives = 63/134 (47%), Gaps = 6/134 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K+K + + E + + ++ +NK ++N+Q+E KN AQL E ++ + ++
Sbjct: 743 KDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKN--AQLLEEVRRREDSMADNSQHL 800
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIN---DMRSRIIE-LEKKCEALD 211
E+ L K R + Q + AEK + + N + R ++ E LE K EAL
Sbjct: 801 QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALL 860
Query: 212 NEVYDKQMELSSLE 225
+ +K ++ LE
Sbjct: 861 AAISEKDANIALLE 874
>BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein.
Length = 957
Score = 71.7 bits (168), Expect = 8e-12
Identities = 119/547 (21%), Positives = 236/547 (43%), Gaps = 38/547 (6%)
Query: 201 IEL-EKKCEALDNEVYDKQM-ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
IEL E+ L E +D+Q EL L + + + + ++ L + + ++ + + L+
Sbjct: 256 IELTEENFRRLQAE-HDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 314
Query: 259 VKGHHALALEA-NESIRR--EYKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASI 314
KG + +LE NE RR E + ++ L+ LD+ EK+ I + ++ + + A
Sbjct: 315 -KGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKT 373
Query: 315 ESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
++L+ +M K +LE+ L + Q +KA E E++K E+ ++ S+ +
Sbjct: 374 KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV-YKSHSKFM 432
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEI 432
+ Q ++ + E E+ L+ L+ +NQNSD KQ + LK E+
Sbjct: 433 KTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 492
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
L+ L EK ++ N+K K ++ +EK + +D++ V ++ ++
Sbjct: 493 DALRLRLEEKE-SFLNKKTK---QLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI 548
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
E L++Q++ L++ + + + +NT +EAL + L ++ R
Sbjct: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD 608
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIED----VELLKKES---------NSQIKFLR 599
+ IES + K+ ++ ++ EL E ++L + S +S++K L
Sbjct: 609 RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLE 668
Query: 600 EEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVV 659
+E+K+ C SR + + A + +L+ E Y + V
Sbjct: 669 IAIEQKKEECSKLEAQLKKAHNIEDDSR-MNPEFADQIKQLDKEASYYRDECGKAQAEVD 727
Query: 660 E-LSLLRQ-ENE--ELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQT 715
L +L++ ENE + +A+ S+ + KD + K L K K+N Q
Sbjct: 728 RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK-----KKNAQL 782
Query: 716 ISPLRER 722
+ +R R
Sbjct: 783 LEEVRRR 789
Score = 71.3 bits (167), Expect = 1e-11
Identities = 109/502 (21%), Positives = 207/502 (41%), Gaps = 42/502 (8%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+Q+ D + + LQ LKEL Q N++ E+D K SKL + + T
Sbjct: 140 RQVRD--STMLDLQAQLKEL-----QRENDLLRKELDIKDSKLGSSMNSIKT----FWSP 188
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+ +K + + +R+ L+++ E Q+ + +L++ + + L LQ++ +
Sbjct: 189 ELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN 248
Query: 245 N---ELTLAETQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISK 298
T+ T++ ++ H + +R+ E ++ +E K L+ ++I K
Sbjct: 249 RGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESI--K 306
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
++ K + S+E N+ + EA Q+ +I +Q+ K + EE
Sbjct: 307 KLLEMLQSKGLPSKSLED-DNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQ 365
Query: 359 KICEIQFEERSQSIQE----HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E + Q++ E + E+ I+ LE EI+ LK L + +++
Sbjct: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNLAVEKAIKEKNKFETSL 471
K+ + T+ +E+ + EL+ E N+ + +E + E
Sbjct: 426 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA 485
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
++ + V L LRL E +S L + Q+Q LT K L E+ K+ L E K
Sbjct: 486 AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDML--------EVK 537
Query: 532 EALVNILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEAYRELGTIKNELIED---V 584
E +N+L+ K +E R + +T ++SLQ L T++ L E +
Sbjct: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERII 597
Query: 585 ELLKKESNSQIKFLREEVEKKR 606
E LK++ + EE+E R
Sbjct: 598 ERLKEQRERDDRERLEEIESFR 619
Score = 48.8 bits (111), Expect = 7e-05
Identities = 73/390 (18%), Positives = 170/390 (43%), Gaps = 20/390 (5%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
+I ++++ ++ +I + I +Q+ D ++ L++ +K L T S+ +
Sbjct: 526 EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTD--SSNTDTAL 583
Query: 158 NEIDRKLSKLR--INNTNCHTEHNAVQGTDA-EKVSAMINDMRSRIIELEKKCEALDNEV 214
++ LS+ I E + + + E D++ ++ L+ + ++ +
Sbjct: 584 ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIR 274
D + SSL RDS K L+ + + ++ + +L+ K H+ +E + +
Sbjct: 644 IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK--KAHN---IEDDSRMN 698
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
E+ +++ +LD+E +C Q + + ++ ++N+ +K + + +L S
Sbjct: 699 PEFADQIK----QLDKEASYYRDECGKAQAEV-DRLLEILKEVENEK-NDKDKKIAELES 752
Query: 335 QLIIKEQEMKAKLEQIEESAS-EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
+ ++ K+ ++ + EK K ++ E R + + Q I+ L +++
Sbjct: 753 LTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 812
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ LD T + + +Q L + L E+ +EEI +K E + I+ E + N
Sbjct: 813 RQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS-EKDANIA 871
Query: 454 NLAVEKAIKEKNKFET-SLSVTRD-IVHVL 481
L + + K+K + E +L +D +VH L
Sbjct: 872 LLELSASKKKKTQEEVMALKREKDRLVHQL 901
Score = 41.5 bits (93), Expect = 0.010
Identities = 71/336 (21%), Positives = 137/336 (40%), Gaps = 25/336 (7%)
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
HH +R ++L+A +L E + + + L + N+ ++
Sbjct: 131 HHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPEL 190
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
KE+ E+ ++KEQ M+ EE+ +L I +Q E R+Q H QQE
Sbjct: 191 KKERVLRKEEAARMSVLKEQ-MRV---SHEENQHLQLTIQALQDELRTQRDLNHLLQQES 246
Query: 382 --------TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE-I 432
TI+ E+ + L+ D + L++ L ++ + E + N +E I
Sbjct: 247 GNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQTLNARDESI 305
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
K L + L K + ++ ++ + + E + L V D + LRE
Sbjct: 306 KKLLEMLQSKGLPSKSLEDDNERT--RRMAEAESQVSHLEVILDQKEKENIHLREELHRR 363
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
QL+ + + + V+E + T +L +R+ ++ + +LK+ L +T
Sbjct: 364 SQLQPEPAKTKALQTVIEMKDTKIA-SLERNIRDLEDE----IQMLKANGVL---NTEDR 415
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELI-EDVELL 587
E + IE ++ K ++ +K EL ++ ELL
Sbjct: 416 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELL 451
Score = 36.7 bits (81), Expect = 0.29
Identities = 34/134 (25%), Positives = 63/134 (47%), Gaps = 6/134 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K+K + + E + + ++ +NK ++N+Q+E KN AQL E ++ + ++
Sbjct: 743 KDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKN--AQLLEEVRRREDSMADNSQHL 800
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIN---DMRSRIIE-LEKKCEALD 211
E+ L K R + Q + AEK + + N + R ++ E LE K EAL
Sbjct: 801 QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALL 860
Query: 212 NEVYDKQMELSSLE 225
+ +K ++ LE
Sbjct: 861 AAISEKDANIALLE 874
>AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250kDa
protein.
Length = 2442
Score = 71.7 bits (168), Expect = 8e-12
Identities = 115/516 (22%), Positives = 232/516 (44%), Gaps = 61/516 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+Q E + + + E N +E ++ + +E EL R + EI +KLS
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEA---QLQKAEEAGAELQADLRDIQEEKE--EIQKKLS 697
Query: 166 KLRINNTNCHTEHNAV--QGTDAEKVSAMINDMRSRIIE----LEKKCEALDNEVYDKQM 219
+ R T+ + + E+V A + ++ LE + +A++ + D
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE 757
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
+L L + +S + Q++ + E+T + + +++ V A E + R K+
Sbjct: 758 QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTV----TQAKEVIQGEVRCLKL 813
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKT---KHNASIESLKNQMLKEKCEALEQLHSQL 336
EL+ +++ ++E+ A + ++ KT + A+ E NQ L+EK E H Q
Sbjct: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQE 872
Query: 337 IIKEQEM----KAKLE-QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
+ K E K +LE +++E +E I + EER+Q+ C Q +T E+E
Sbjct: 873 LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET----EKERV 928
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE--KTINYENE 449
L TL T + +D Q+L L + ++ +K E L+ +L E + +
Sbjct: 929 SLLETLLQTQKELADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+++ +LA A++E+ S S+ +D + + ++E L+ Q+ ++ ++
Sbjct: 986 QHRDDLA---ALQEE-----SSSLLQDKM--------DLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
E E + +RE EY + + KA+LT +ME L+ LQ +
Sbjct: 1030 EQE-------VQEKLRETQEYNRIQKELEREKASLT---LSLMEKEQRLL-VLQEADSIR 1078
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+EL ++ ++ ++ + +KE ++Q++ LR+EV++K
Sbjct: 1079 QQELSALRQDM-QEAQGEQKELSAQMELLRQEVKEK 1113
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/488 (20%), Positives = 202/488 (41%), Gaps = 20/488 (4%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q +++ Q +E+ KDQ I Q++D K ++ L+ LA + ++H+ + E
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE----CLALELEENHHKM---ECQ 1572
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+KL K D E+ S + S+I +LE L E+ ++ E+
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV 1632
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S E I + L + L + L ++R+++++ + E + K+ L
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+L ++Q + + + + K + S+E +K +L++K + +E + I + Q
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQ-RGSLEHMK-LILRDKEKEVE-CQQEHIHELQ 1749
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
E+K +LEQ + K+ + +R Q I Q ++ + E + + L+ LD
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA- 460
+ QEL L+ + + ++ E+ L+ L + + + +L E+A
Sbjct: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR 1869
Query: 461 -IKEKNKFE-TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
++E+ E + +++ L RE + L L+ Q EV L
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWL 1929
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKN 578
++E D+ EAL +S+++ +E E E+LQ +A+ L +
Sbjct: 1930 QAQAVLKERDQELEAL--RAESQSSRHQE-----EAARARAEALQEALGKAHAALQGKEQ 1982
Query: 579 ELIEDVEL 586
L+E EL
Sbjct: 1983 HLLEQAEL 1990
Score = 68.9 bits (161), Expect = 6e-11
Identities = 105/519 (20%), Positives = 235/519 (45%), Gaps = 42/519 (8%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA 186
++D + ++A QE + L + Q + + ++L KL + +QG +
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEE--EGKALRQRLQKLTGERDTLAGQTVDLQG-EV 458
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +S ++ EL ++ E L+ E + ++ ++E + DS +E+
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLEQEAW--RLRRVNVELQLQ-GDSAQGQKEEQQEELH 515
Query: 247 LTLAETQQRLEMVKGHHALALEA-NESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
L + E ++ EM+ G A E+ +E I +E L+ +L ++Q ++ E
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 306 LKTKHNASIESLKNQMLK-----EKCEALEQ--------LHSQLIIKEQEMKAKLEQIE- 351
+ ++S +LK ++ K AL + L+ QL+ E+E ++ ++E
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 352 -ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE 410
E A L++ + E+R +++ E + E +Q E+ EL+ L + +++++
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 411 LNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNL---AVEKAIKEK 464
L+ ++ ++ +T+ +E K ++ L E EK L + AVE+ ++
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELE----QLEDQVQMLTSAKEVLENELTTYKNTL 520
+ LS ++++ ++ +S +E QLE Q+Q +T AKEV++ E+ K L
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 521 NNTVRECDEYKEALVNIL-----KSKAALTKEHTRIMEHNVTLIESLQNV----EKEAYR 571
+ + ++ ++A L + K AL ++ + L E + ++E +
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
L +++ E +E +E+ KE ++++ ++ + E++R E
Sbjct: 876 ALESLEREKME-LEMRLKEQQTEMEAIQAQREEERTQAE 913
Score = 66.9 bits (156), Expect = 2e-10
Identities = 106/516 (20%), Positives = 229/516 (44%), Gaps = 40/516 (7%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
EL Q +N+++ KQ ++E+ +L E + L ++ R++ + +R+
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQ-NSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N EH +A ++ + + + + EV ++ +
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L+E ++ + K LQE L TLAE ++ +E ++G ++ E R K LE
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ----IQELEKQREMQKAALEL 1460
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
L L + Q + + QE ++ +E ++ +L+ A+++ +L ++ +++
Sbjct: 1461 LSLDLKKRNQEV----DLQQEQIQ-----ELEKCRS-VLEHLPMAVQEREQKLTVQREQI 1510
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK-YTLDLTNN 402
+ +LE+ E+ L+ ++ E++ Q I+ Q +Q L++++ L+ L+L N
Sbjct: 1511 R-ELEKDRETQRNVLEHQLLELEKKDQMIE----SQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 403 QNS-DLKQEL-NNLKNCKDELSTEKFNFIEEIKTLKDEL-IEKTINYENEKNKLNLAVEK 459
+ + +Q+L L+ ++ + +++ EL + + ++ E + LA E
Sbjct: 1566 HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL 1625
Query: 460 AIKE---KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQML----TSAKEVLENE 512
++ K++ E + R H LT L D EL ++++Q+L T ++LE +
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEH-LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED 1684
Query: 513 LTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE 572
L K +L RE ++ + + +K +EH + LI L++ EKE
Sbjct: 1685 LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH-MKLI--LRDKEKEV--- 1738
Query: 573 LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ E I +++ LK + Q++ L +V + +L
Sbjct: 1739 --ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Score = 60.5 bits (140), Expect = 2e-08
Identities = 108/515 (20%), Positives = 223/515 (43%), Gaps = 78/515 (15%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
+D E+ Q + Q E K + LQ L++ ++ H + D K R
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ----DHKEQARR 1870
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK----QMELSSL 224
+ E AV+G + + ++ D+R+ E EK AL + ++ ++E +L
Sbjct: 1871 LE------EELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI---------RR 275
++ ++ K+ ++L E AE+Q + A A E++ +
Sbjct: 1925 QDSWLQAQAVLKERDQEL---EALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKE 1981
Query: 276 EYKIELEALKTKLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL 332
++ +E L L+ QA + C+ L+ +++Q L+ + E ++QL
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ-EDVQQL 2040
Query: 333 HSQLIIKEQEMKAKLEQ---IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
L +++E++ + E+ +E+S +++++ E +E+ QE ++E+ I+ L Q
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQ--ENMIQEKQNLGQE---REEEEIRGLHQS 2095
Query: 390 IKELKYTLDLTNNQNSDLK--QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
++EL+ TL + +L+ Q+ NNL+ T E ++LK + +E + E
Sbjct: 2096 VRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPM----EEQSLKLDSLEPRLQRE 2151
Query: 448 NEKNKLNLAVEKA--IKEKNKFE----------TSLSVTRDIVHVLTLRLRESDSELEQL 495
E+ + L +A I+ + K + S+S +++ L + E DSE ++L
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 496 EDQVQMLTSA--KEVLENELTTYKNTLNNTVR--------------------ECDEYKEA 533
+D++++ A KE L + T L + E +++
Sbjct: 2212 QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR 2271
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++ ++ A L + +R+ HNV L +L+ VE+E
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERE 2306
Score = 59.7 bits (138), Expect = 4e-08
Identities = 87/443 (19%), Positives = 182/443 (41%), Gaps = 33/443 (7%)
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK 359
K+ Q+ KT+ + + Q L+E+ E SQ+ + Q+++ +L Q +E S K +
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-KWE 1305
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
+ E + E + + ++ E + E + +L +L ++ +L+
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 420 ELSTEKF--NFIEE-IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS-VTR 475
E + +EE ++T + L K E+E+ + +A++E+ + + + +
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERA-----QALQEQGELKVAQGKALQ 1420
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+ + +LT L E + E+E L Q+Q L +E+ + L L +E D +E +
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 536 NILKSKAALTKEHTRIMEHNVTLI---ESLQNVEKEAYRELGTIKNELIE---------- 582
+ K ++ L + E L E ++ +EK+ + ++++L+E
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 583 ---DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSR 639
V+ LKK+ + ++ L E+E+ E RV L D
Sbjct: 1541 QRGQVQDLKKQLVT-LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD--- 1596
Query: 640 LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSP 699
LE ++ L ++L +E +E V Q I++L++ Q ++ +
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR---QKEHLTQDL 1653
Query: 700 SVLRKSLKVGKENMQTISPLRER 722
+ L + KE +Q + R R
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTR 1676
Score = 57.6 bits (133), Expect = 1e-07
Identities = 73/317 (23%), Positives = 146/317 (46%), Gaps = 28/317 (8%)
Query: 195 DMRSRIIELEKKCEALDNEVYDKQMELSSL----EEVITVRDSLCKDLQEKLTSNELTLA 250
++ + LE++ L+ + ++Q E+ ++ EE T +S +Q + ++L
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL 931
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKI----ELEA---LKTKLDEEKQAIISKCKVDQ 303
ET L + A A + E +R++ K+ E E L+T+L E ++ + + +
Sbjct: 932 ET---LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L S L+++M +K +E L SQL+ ++ + +E+ EKL+ E
Sbjct: 989 DDLAALQEESSSLLQDKMDLQK--QVEDLKSQLVAQDDSQRL----VEQEVQEKLR--ET 1040
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
Q R Q E + T+ +E+E + L + +S +QEL+ L+ E
Sbjct: 1041 QEYNRIQKELER-EKASLTLSLMEKEQRLL-----VLQEADSIRQQELSALRQDMQEAQG 1094
Query: 424 EKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
E+ +++ L+ E+ EK ++ ++ +L +E + + + SL L L
Sbjct: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
Query: 484 RLRESDSELEQLEDQVQ 500
RLR ++S+LE L + Q
Sbjct: 1155 RLRSTESQLEALAAEQQ 1171
Score = 52.8 bits (121), Expect = 4e-06
Identities = 79/380 (20%), Positives = 157/380 (41%), Gaps = 18/380 (4%)
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
K + E + ERSQ + + SQ + L+ + EL L + QN D ++ + L+
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEKTINYENE-KNKLNLAVEKA--IKEKNKFETSLSV 473
+ L T +E +L E+ ++ + K+ + VE+ I + + E SL +
Sbjct: 312 TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL 371
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
I +++D L + + A + L +L + +N ++ D+++E
Sbjct: 372 DSSIFS--QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEE 429
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE-LGTIKNELIEDVELLKKESN 592
+ + LT E + V L + ++ KE RE L + EL + +E+L++E+
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE--RELLQKAREELRQQLEVLEQEA- 486
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN-ERYXXXX 651
+++ + E++ + + R L + L ++E+
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 652 XXXXSLVVELSLLRQENEELT-------MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRK 704
S +E LLRQE E+T ++A+ SS + LK ++ + S L +
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 705 SLKVGKENM-QTISPLRERN 723
+L + K + Q + L E N
Sbjct: 607 ALALDKVGLNQQLLQLEEEN 626
Score = 43.6 bits (98), Expect = 0.003
Identities = 60/301 (19%), Positives = 127/301 (42%), Gaps = 14/301 (4%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E ++ Q+ EI+++D Y + ++ + +AQ E L+ + + ++ +
Sbjct: 2016 EEALRIQEGEIQDQD---LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 163 KLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME 220
+ + + N E ++G ++ + I+EL + + + E +
Sbjct: 2073 MIQEKQ--NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LEMVKGHHALAL-----EANESIR 274
S +EE DSL LQ +L + L +T+ R +E + LAL +A+ S
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
+E + L+A + D E+Q + + ++ + L+ + S + L + E QL
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGE 2250
Query: 335 QLIIKEQEMKAKLE-QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
++ + +E Q E L+ + E +Q H Q T++ +E+E ++L
Sbjct: 2251 VSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
Query: 394 K 394
K
Sbjct: 2311 K 2311
Score = 38.7 bits (86), Expect = 0.072
Identities = 90/444 (20%), Positives = 179/444 (40%), Gaps = 45/444 (10%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R +E++ + E+ + + LS +R ++ +E S + E Q L
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
++ L EA+E + EL LK++ D EK + + + L T+ E
Sbjct: 248 LLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRV-TELSALLTQSQKQNED 301
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK-ICEIQFEERSQSIQ 373
+ + L+E E LE H++L+ E + ++ + S + +K I ++ EE Q
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 374 ----EHCSQQEKTI------QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
E+ + + +I Q ++ + ++ L DL+Q+L + + L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
Query: 424 EKFNFIEEIKTL----------KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
+ + EE K L +D L +T++ + E + L+ E K + + L V
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 474 -------TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE 526
R + L L+ + + E+ ++++ + +E L+ L + + ++ E
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541
Query: 527 CDEYKEALVNILKSKAALTKEHTRI------MEHNVTLIESLQNVEKEAYREL--GTIK- 577
+EAL + L +E T + E ++ + S +N K +L +K
Sbjct: 542 LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL 601
Query: 578 NELIEDVELLKKESNSQIKFLREE 601
+ L E + L K N Q+ L EE
Sbjct: 602 SALNEALALDKVGLNQQLLQLEEE 625
>AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associated
protein 1 protein.
Length = 2442
Score = 71.7 bits (168), Expect = 8e-12
Identities = 115/516 (22%), Positives = 232/516 (44%), Gaps = 61/516 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+Q E + + + E N +E ++ + +E EL R + EI +KLS
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEA---QLQKAEEAGAELQADLRDIQEEKE--EIQKKLS 697
Query: 166 KLRINNTNCHTEHNAV--QGTDAEKVSAMINDMRSRIIE----LEKKCEALDNEVYDKQM 219
+ R T+ + + E+V A + ++ LE + +A++ + D
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE 757
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
+L L + +S + Q++ + E+T + + +++ V A E + R K+
Sbjct: 758 QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTV----TQAKEVIQGEVRCLKL 813
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKT---KHNASIESLKNQMLKEKCEALEQLHSQL 336
EL+ +++ ++E+ A + ++ KT + A+ E NQ L+EK E H Q
Sbjct: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQE 872
Query: 337 IIKEQEM----KAKLE-QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
+ K E K +LE +++E +E I + EER+Q+ C Q +T E+E
Sbjct: 873 LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET----EKERV 928
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE--KTINYENE 449
L TL T + +D Q+L L + ++ +K E L+ +L E + +
Sbjct: 929 SLLETLLQTQKELADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+++ +LA A++E+ S S+ +D + + ++E L+ Q+ ++ ++
Sbjct: 986 QHRDDLA---ALQEE-----SSSLLQDKM--------DLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
E E + +RE EY + + KA+LT +ME L+ LQ +
Sbjct: 1030 EQE-------VQEKLRETQEYNRIQKELEREKASLT---LSLMEKEQRLL-VLQEADSIR 1078
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+EL ++ ++ ++ + +KE ++Q++ LR+EV++K
Sbjct: 1079 QQELSALRQDM-QEAQGEQKELSAQMELLRQEVKEK 1113
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/488 (20%), Positives = 202/488 (41%), Gaps = 20/488 (4%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q +++ Q +E+ KDQ I Q++D K ++ L+ LA + ++H+ + E
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE----CLALELEENHHKM---ECQ 1572
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+KL K D E+ S + S+I +LE L E+ ++ E+
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV 1632
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S E I + L + L + L ++R+++++ + E + K+ L
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+L ++Q + + + + K + S+E +K +L++K + +E + I + Q
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQ-RGSLEHMK-LILRDKEKEVE-CQQEHIHELQ 1749
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
E+K +LEQ + K+ + +R Q I Q ++ + E + + L+ LD
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA- 460
+ QEL L+ + + ++ E+ L+ L + + + +L E+A
Sbjct: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR 1869
Query: 461 -IKEKNKFE-TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
++E+ E + +++ L RE + L L+ Q EV L
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWL 1929
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKN 578
++E D+ EAL +S+++ +E E E+LQ +A+ L +
Sbjct: 1930 QAQAVLKERDQELEAL--RAESQSSRHQE-----EAARARAEALQEALGKAHAALQGKEQ 1982
Query: 579 ELIEDVEL 586
L+E EL
Sbjct: 1983 HLLEQAEL 1990
Score = 69.7 bits (163), Expect = 3e-11
Identities = 106/519 (20%), Positives = 233/519 (44%), Gaps = 42/519 (8%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA 186
++D + ++A QE + L + Q + + ++L KL + +QG +
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEE--EGKALRQRLQKLTGERDTLAGQTVDLQG-EV 458
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +S ++ EL ++ E L+ E + + L+ +D QE+L
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEEL---H 515
Query: 247 LTLAETQQRLEMVKGHHALALEA-NESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
L + E ++ EM+ G A E+ +E I +E L+ +L ++Q ++ E
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 306 LKTKHNASIESLKNQMLK-----EKCEALEQ--------LHSQLIIKEQEMKAKLEQIE- 351
+ ++S +LK ++ K AL + L+ QL+ E+E ++ ++E
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 352 -ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE 410
E A L++ + E+R +++ E + E +Q E+ EL+ L + +++++
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 411 LNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNL---AVEKAIKEK 464
L+ ++ ++ +T+ +E K ++ L E EK L + AVE+ ++
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELE----QLEDQVQMLTSAKEVLENELTTYKNTL 520
+ LS ++++ ++ +S +E QLE Q+Q +T AKEV++ E+ K L
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 521 NNTVRECDEYKEALVNIL-----KSKAALTKEHTRIMEHNVTLIESLQNV----EKEAYR 571
+ + ++ ++A L + K AL ++ + L E + ++E +
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
L +++ E +E +E+ KE ++++ ++ + E++R E
Sbjct: 876 ALESLEREKME-LEMRLKEQQTEMEAIQAQREEERTQAE 913
Score = 66.9 bits (156), Expect = 2e-10
Identities = 106/516 (20%), Positives = 229/516 (44%), Gaps = 40/516 (7%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
EL Q +N+++ KQ ++E+ +L E + L ++ R++ + +R+
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQ-NSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N EH +A ++ + + + + EV ++ +
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L+E ++ + K LQE L TLAE ++ +E ++G ++ E R K LE
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ----IQELEKQREMQKAALEL 1460
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
L L + Q + + QE ++ +E ++ +L+ A+++ +L ++ +++
Sbjct: 1461 LSLDLKKRNQEV----DLQQEQIQ-----ELEKCRS-VLEHLPMAVQEREQKLTVQREQI 1510
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK-YTLDLTNN 402
+ +LE+ E+ L+ ++ E++ Q I+ Q +Q L++++ L+ L+L N
Sbjct: 1511 R-ELEKDRETQRNVLEHQLLELEKKDQMIE----SQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 403 QNS-DLKQEL-NNLKNCKDELSTEKFNFIEEIKTLKDEL-IEKTINYENEKNKLNLAVEK 459
+ + +Q+L L+ ++ + +++ EL + + ++ E + LA E
Sbjct: 1566 HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL 1625
Query: 460 AIKE---KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQML----TSAKEVLENE 512
++ K++ E + R H LT L D EL ++++Q+L T ++LE +
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEH-LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED 1684
Query: 513 LTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE 572
L K +L RE ++ + + +K +EH + LI L++ EKE
Sbjct: 1685 LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH-MKLI--LRDKEKEV--- 1738
Query: 573 LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ E I +++ LK + Q++ L +V + +L
Sbjct: 1739 --ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Score = 60.5 bits (140), Expect = 2e-08
Identities = 108/515 (20%), Positives = 223/515 (43%), Gaps = 78/515 (15%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
+D E+ Q + Q E K + LQ L++ ++ H + D K R
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ----DHKEQARR 1870
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK----QMELSSL 224
+ E AV+G + + ++ D+R+ E EK AL + ++ ++E +L
Sbjct: 1871 LE------EELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI---------RR 275
++ ++ K+ ++L E AE+Q + A A E++ +
Sbjct: 1925 QDSWLQAQAVLKERDQEL---EALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKE 1981
Query: 276 EYKIELEALKTKLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL 332
++ +E L L+ QA + C+ L+ +++Q L+ + E ++QL
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ-EDVQQL 2040
Query: 333 HSQLIIKEQEMKAKLEQ---IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
L +++E++ + E+ +E+S +++++ E +E+ QE ++E+ I+ L Q
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQ--ENMIQEKQNLGQE---REEEEIRGLHQS 2095
Query: 390 IKELKYTLDLTNNQNSDLK--QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
++EL+ TL + +L+ Q+ NNL+ T E ++LK + +E + E
Sbjct: 2096 VRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPM----EEQSLKLDSLEPRLQRE 2151
Query: 448 NEKNKLNLAVEKA--IKEKNKFE----------TSLSVTRDIVHVLTLRLRESDSELEQL 495
E+ + L +A I+ + K + S+S +++ L + E DSE ++L
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 496 EDQVQMLTSA--KEVLENELTTYKNTLNNTVR--------------------ECDEYKEA 533
+D++++ A KE L + T L + E +++
Sbjct: 2212 QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR 2271
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++ ++ A L + +R+ HNV L +L+ VE+E
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERE 2306
Score = 59.7 bits (138), Expect = 4e-08
Identities = 87/443 (19%), Positives = 182/443 (41%), Gaps = 33/443 (7%)
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK 359
K+ Q+ KT+ + + Q L+E+ E SQ+ + Q+++ +L Q +E S K +
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-KWE 1305
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
+ E + E + + ++ E + E + +L +L ++ +L+
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 420 ELSTEKF--NFIEE-IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS-VTR 475
E + +EE ++T + L K E+E+ + +A++E+ + + + +
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERA-----QALQEQGELKVAQGKALQ 1420
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+ + +LT L E + E+E L Q+Q L +E+ + L L +E D +E +
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 536 NILKSKAALTKEHTRIMEHNVTLI---ESLQNVEKEAYRELGTIKNELIE---------- 582
+ K ++ L + E L E ++ +EK+ + ++++L+E
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 583 ---DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSR 639
V+ LKK+ + ++ L E+E+ E RV L D
Sbjct: 1541 QRGQVQDLKKQLVT-LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD--- 1596
Query: 640 LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSP 699
LE ++ L ++L +E +E V Q I++L++ Q ++ +
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR---QKEHLTQDL 1653
Query: 700 SVLRKSLKVGKENMQTISPLRER 722
+ L + KE +Q + R R
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTR 1676
Score = 57.6 bits (133), Expect = 1e-07
Identities = 73/317 (23%), Positives = 146/317 (46%), Gaps = 28/317 (8%)
Query: 195 DMRSRIIELEKKCEALDNEVYDKQMELSSL----EEVITVRDSLCKDLQEKLTSNELTLA 250
++ + LE++ L+ + ++Q E+ ++ EE T +S +Q + ++L
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL 931
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKI----ELEA---LKTKLDEEKQAIISKCKVDQ 303
ET L + A A + E +R++ K+ E E L+T+L E ++ + + +
Sbjct: 932 ET---LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L S L+++M +K +E L SQL+ ++ + +E+ EKL+ E
Sbjct: 989 DDLAALQEESSSLLQDKMDLQK--QVEDLKSQLVAQDDSQRL----VEQEVQEKLR--ET 1040
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
Q R Q E + T+ +E+E + L + +S +QEL+ L+ E
Sbjct: 1041 QEYNRIQKELER-EKASLTLSLMEKEQRLL-----VLQEADSIRQQELSALRQDMQEAQG 1094
Query: 424 EKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTL 483
E+ +++ L+ E+ EK ++ ++ +L +E + + + SL L L
Sbjct: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
Query: 484 RLRESDSELEQLEDQVQ 500
RLR ++S+LE L + Q
Sbjct: 1155 RLRSTESQLEALAAEQQ 1171
Score = 52.8 bits (121), Expect = 4e-06
Identities = 79/380 (20%), Positives = 157/380 (41%), Gaps = 18/380 (4%)
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
K + E + ERSQ + + SQ + L+ + EL L + QN D ++ + L+
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEKTINYENE-KNKLNLAVEKA--IKEKNKFETSLSV 473
+ L T +E +L E+ ++ + K+ + VE+ I + + E SL +
Sbjct: 312 TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL 371
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
I +++D L + + A + L +L + +N ++ D+++E
Sbjct: 372 DSSIFS--QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEE 429
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE-LGTIKNELIEDVELLKKESN 592
+ + LT E + V L + ++ KE RE L + EL + +E+L++E+
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE--RELLQKAREELRQQLEVLEQEA- 486
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN-ERYXXXX 651
+++ + E++ + + R L + L ++E+
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 652 XXXXSLVVELSLLRQENEELT-------MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRK 704
S +E LLRQE E+T ++A+ SS + LK ++ + S L +
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 705 SLKVGKENM-QTISPLRERN 723
+L + K + Q + L E N
Sbjct: 607 ALALDKVGLNQQLLQLEEEN 626
Score = 43.6 bits (98), Expect = 0.003
Identities = 60/301 (19%), Positives = 127/301 (42%), Gaps = 14/301 (4%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E ++ Q+ EI+++D Y + ++ + +AQ E L+ + + ++ +
Sbjct: 2016 EEALRIQEGEIQDQD---LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 163 KLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME 220
+ + + N E ++G ++ + I+EL + + + E +
Sbjct: 2073 MIQEKQ--NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LEMVKGHHALAL-----EANESIR 274
S +EE DSL LQ +L + L +T+ R +E + LAL +A+ S
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
+E + L+A + D E+Q + + ++ + L+ + S + L + E QL
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGE 2250
Query: 335 QLIIKEQEMKAKLE-QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
++ + +E Q E L+ + E +Q H Q T++ +E+E ++L
Sbjct: 2251 VSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
Query: 394 K 394
K
Sbjct: 2311 K 2311
Score = 38.7 bits (86), Expect = 0.072
Identities = 95/444 (21%), Positives = 180/444 (40%), Gaps = 45/444 (10%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R +E++ + E+ + + LS +R ++ +E S + E Q L
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
++ L EA+E + EL LK++ D EK + + + L T+ E
Sbjct: 248 LLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRV-TELSALLTQSQKQNED 301
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK-ICEIQFEERSQSIQ 373
+ + L+E E LE H++L+ E + ++ + S + +K I ++ EE Q
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 374 ----EHCSQQEKTI------QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
E+ + + +I Q ++ + ++ L DL+Q+L + + L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
Query: 424 EKFNFIEEIKTL----------KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
+ + EE K L +D L +T++ + E + L+ E K + + L V
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 474 TRD---IVHVLTLRLR-ESDSELEQLEDQVQMLTSA---KEVLENELTTYKNTLNNTVRE 526
+ + + L+ + DS Q EDQ + L A +E L+ L + + ++ E
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541
Query: 527 CDEYKEALVNILKSKAALTKEHTRI------MEHNVTLIESLQNVEKEAYREL--GTIK- 577
+EAL + L +E T + E ++ + S +N K +L +K
Sbjct: 542 LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL 601
Query: 578 NELIEDVELLKKESNSQIKFLREE 601
+ L E + L K N Q+ L EE
Sbjct: 602 SALNEALALDKVGLNQQLLQLEEE 625
>AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein.
Length = 970
Score = 71.7 bits (168), Expect = 8e-12
Identities = 119/547 (21%), Positives = 236/547 (43%), Gaps = 38/547 (6%)
Query: 201 IEL-EKKCEALDNEVYDKQM-ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
IEL E+ L E +D+Q EL L + + + + ++ L + + ++ + + L+
Sbjct: 269 IELTEENFRRLQAE-HDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 327
Query: 259 VKGHHALALEA-NESIRR--EYKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASI 314
KG + +LE NE RR E + ++ L+ LD+ EK+ I + ++ + + A
Sbjct: 328 -KGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKT 386
Query: 315 ESLKN--QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
++L+ +M K +LE+ L + Q +KA E E++K E+ ++ S+ +
Sbjct: 387 KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV-YKSHSKFM 445
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEI 432
+ Q ++ + E E+ L+ L+ +NQNSD KQ + LK E+
Sbjct: 446 KTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 505
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
L+ L EK ++ N+K K ++ +EK + +D++ V ++ ++
Sbjct: 506 DALRLRLEEKE-SFLNKKTK---QLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI 561
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
E L++Q++ L++ + + + +NT +EAL + L ++ R
Sbjct: 562 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD 621
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIED----VELLKKES---------NSQIKFLR 599
+ IES + K+ ++ ++ EL E ++L + S +S++K L
Sbjct: 622 RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLE 681
Query: 600 EEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVV 659
+E+K+ C SR + + A + +L+ E Y + V
Sbjct: 682 IAIEQKKEECSKLEAQLKKAHNIEDDSR-MNPEFADQIKQLDKEASYYRDECGKAQAEVD 740
Query: 660 E-LSLLRQ-ENE--ELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQT 715
L +L++ ENE + +A+ S+ + KD + K L K K+N Q
Sbjct: 741 RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK-----KKNAQL 795
Query: 716 ISPLRER 722
+ +R R
Sbjct: 796 LEEVRRR 802
Score = 71.3 bits (167), Expect = 1e-11
Identities = 109/502 (21%), Positives = 207/502 (41%), Gaps = 42/502 (8%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+Q+ D + + LQ LKEL Q N++ E+D K SKL + + T
Sbjct: 153 RQVRD--STMLDLQAQLKEL-----QRENDLLRKELDIKDSKLGSSMNSIKT----FWSP 201
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
+ +K + + +R+ L+++ E Q+ + +L++ + + L LQ++ +
Sbjct: 202 ELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN 261
Query: 245 N---ELTLAETQQRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISK 298
T+ T++ ++ H + +R+ E ++ +E K L+ ++I K
Sbjct: 262 RGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESI--K 319
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
++ K + S+E N+ + EA Q+ +I +Q+ K + EE
Sbjct: 320 KLLEMLQSKGLPSKSLED-DNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQ 378
Query: 359 KICEIQFEERSQSIQE----HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E + Q++ E + E+ I+ LE EI+ LK L + +++
Sbjct: 379 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 438
Query: 415 KNCKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNLAVEKAIKEKNKFETSL 471
K+ + T+ +E+ + EL+ E N+ + +E + E
Sbjct: 439 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA 498
Query: 472 SVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
++ + V L LRL E +S L + Q+Q LT K L E+ K+ L E K
Sbjct: 499 AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDML--------EVK 550
Query: 532 EALVNILKSKAALTKEHTRIMEHNVT----LIESLQNVEKEAYRELGTIKNELIED---V 584
E +N+L+ K +E R + +T ++SLQ L T++ L E +
Sbjct: 551 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERII 610
Query: 585 ELLKKESNSQIKFLREEVEKKR 606
E LK++ + EE+E R
Sbjct: 611 ERLKEQRERDDRERLEEIESFR 632
Score = 48.8 bits (111), Expect = 7e-05
Identities = 73/390 (18%), Positives = 170/390 (43%), Gaps = 20/390 (5%)
Query: 98 KILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF 157
+I ++++ ++ +I + I +Q+ D ++ L++ +K L T S+ +
Sbjct: 539 EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTD--SSNTDTAL 596
Query: 158 NEIDRKLSKLR--INNTNCHTEHNAVQGTDA-EKVSAMINDMRSRIIELEKKCEALDNEV 214
++ LS+ I E + + + E D++ ++ L+ + ++ +
Sbjct: 597 ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 656
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIR 274
D + SSL RDS K L+ + + ++ + +L+ K H+ +E + +
Sbjct: 657 IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK--KAHN---IEDDSRMN 711
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
E+ +++ +LD+E +C Q + + ++ ++N+ +K + + +L S
Sbjct: 712 PEFADQIK----QLDKEASYYRDECGKAQAEV-DRLLEILKEVENEK-NDKDKKIAELES 765
Query: 335 QLIIKEQEMKAKLEQIEESAS-EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
+ ++ K+ ++ + EK K ++ E R + + Q I+ L +++
Sbjct: 766 LTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 825
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ LD T + + +Q L + L E+ +EEI +K E + I+ E + N
Sbjct: 826 RQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS-EKDANIA 884
Query: 454 NLAVEKAIKEKNKFET-SLSVTRD-IVHVL 481
L + + K+K + E +L +D +VH L
Sbjct: 885 LLELSASKKKKTQEEVMALKREKDRLVHQL 914
Score = 41.5 bits (93), Expect = 0.010
Identities = 71/336 (21%), Positives = 137/336 (40%), Gaps = 25/336 (7%)
Query: 262 HHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM 321
HH +R ++L+A +L E + + + L + N+ ++
Sbjct: 144 HHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPEL 203
Query: 322 LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEK 381
KE+ E+ ++KEQ M+ EE+ +L I +Q E R+Q H QQE
Sbjct: 204 KKERVLRKEEAARMSVLKEQ-MRV---SHEENQHLQLTIQALQDELRTQRDLNHLLQQES 259
Query: 382 --------TIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE-I 432
TI+ E+ + L+ D + L++ L ++ + E + N +E I
Sbjct: 260 GNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQTLNARDESI 318
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
K L + L K + ++ ++ + + E + L V D + LRE
Sbjct: 319 KKLLEMLQSKGLPSKSLEDDNERT--RRMAEAESQVSHLEVILDQKEKENIHLREELHRR 376
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
QL+ + + + V+E + T +L +R+ ++ + +LK+ L +T
Sbjct: 377 SQLQPEPAKTKALQTVIEMKDTKIA-SLERNIRDLEDE----IQMLKANGVL---NTEDR 428
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELI-EDVELL 587
E + IE ++ K ++ +K EL ++ ELL
Sbjct: 429 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELL 464
Score = 36.7 bits (81), Expect = 0.29
Identities = 34/134 (25%), Positives = 63/134 (47%), Gaps = 6/134 (4%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K+K + + E + + ++ +NK ++N+Q+E KN AQL E ++ + ++
Sbjct: 756 KDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKN--AQLLEEVRRREDSMADNSQHL 813
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIN---DMRSRIIE-LEKKCEALD 211
E+ L K R + Q + AEK + + N + R ++ E LE K EAL
Sbjct: 814 QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALL 873
Query: 212 NEVYDKQMELSSLE 225
+ +K ++ LE
Sbjct: 874 AAISEKDANIALLE 887
>BX537985-1|CAD97945.1| 1202|Homo sapiens hypothetical protein
protein.
Length = 1202
Score = 71.3 bits (167), Expect = 1e-11
Identities = 110/499 (22%), Positives = 218/499 (43%), Gaps = 42/499 (8%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
+D ++ +V+I N ++ +K+I YK +L+E+ KE K ID
Sbjct: 23 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE--NKELVKRATIDI---- 76
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+ L LR + ++ K M ND+ ELEK + ++D+Q
Sbjct: 77 KTLVTLREDLV-----------SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 125
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S +++ L L++ L E +A + RLE ++ + +++++ Y
Sbjct: 126 DSRYKLL--ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY---- 179
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
EALK + DEE+ + S + E+ K + + + + +K++ +E+ ++ L ++Q
Sbjct: 180 EALKQRQDEERM-VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ 238
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
+K +L+Q+ E+ + L+ + + ++ S+QE + + L+ E L
Sbjct: 239 ALKTQLKQL-ETQNNNLQTQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 297
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI---EK-TINYENEKNKLNLAV 457
NQN+ L + ++L+N + + E+ E++K+L D LI EK + +E + ++ +
Sbjct: 298 NQNAQLLIQQSSLENENESVIKER----EDLKSLYDSLIKDHEKLELLHERQASEYESLI 353
Query: 458 EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-LTTY 516
K K+ + RD+ L++ +LE LE ++ + K +LEN+ T
Sbjct: 354 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK-GQLEDLEKMLK-VEQEKMLLENKNHETV 411
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRI--MEHNVTLIESLQNVE----KEAY 570
E D +LK L +H + + +N L ++ E KE Y
Sbjct: 412 AAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 471
Query: 571 RELGTIKNELIEDVELLKK 589
++L +L ELL +
Sbjct: 472 QQLDITSTKLNNQCELLSQ 490
Score = 53.6 bits (123), Expect = 2e-06
Identities = 92/434 (21%), Positives = 174/434 (40%), Gaps = 47/434 (10%)
Query: 270 NESIRRE---YKIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIESLKNQMLKEK 325
N+++ +E YK LK +L++E + ++ + +D + L T + + E LK Q +
Sbjct: 41 NKTLSKEIGIYKESCVRLK-ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 99
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
E L ++ + ++ + L + + + K+ E + E S +K+++
Sbjct: 100 LEKLTHELEKIGLNKERL---LHDEQSTDDSRYKLLESKLE----------STLKKSLEI 146
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE--LIEKT 443
E++I L+ L+ + N N L+QEL +K N+ E +K +DE +++ +
Sbjct: 147 KEEKIAALEARLEESTNYNQQLRQELKTVKK----------NY-EALKQRQDEERMVQSS 195
Query: 444 INYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLT 503
E NK ++ +E K + L L + ++L+QLE Q L
Sbjct: 196 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 255
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI---E 560
+ ++L + T NT + K + N + L + T +M N L+
Sbjct: 256 T--QILALQRQTVSLQEQNTTLQTQNAKLQVEN-----STLNSQSTSLMNQNAQLLIQQS 308
Query: 561 SLQNVEKEAYRE---LGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXX 617
SL+N + +E L ++ + LI+D E L+ Q + K L
Sbjct: 309 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 368
Query: 618 XXXXXXXXSRVLLAQAA--ADLSR-LENENERYXXXXXXXXSLVVELSLLRQENEELTMT 674
LL Q DL + L+ E E+ ++ E L EN+ L T
Sbjct: 369 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 428
Query: 675 VAKQSSIIDKLKKD 688
++ + L+ D
Sbjct: 429 YSQLLKETEVLQTD 442
Score = 53.6 bits (123), Expect = 2e-06
Identities = 82/419 (19%), Positives = 185/419 (44%), Gaps = 37/419 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQ---DVEIRNKDQTI---CEYNKQIEDYKNEIAQLQE 139
S++KK+L + KI + ++ + ++R + +T+ E KQ +D + +
Sbjct: 138 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 197
Query: 140 ILKELATKFRQSHNNI-DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
I E R+S + ++ +L ++ NN E A++ T +++ N++++
Sbjct: 198 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK-TQLKQLETQNNNLQT 256
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEM 258
+I+ L+++ +L + Q + + L+ + +S L + + + + E
Sbjct: 257 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 316
Query: 259 VKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK---CKVDQENLKTKHNASIE 315
V +S+ ++++ +LE L + E +++ISK K +NL+ +H +E
Sbjct: 317 VIKEREDLKSLYDSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-DLE 374
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICE------------- 362
NQ+LK+K + LE L L +++++M + + E A+E K+C
Sbjct: 375 DRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 433
Query: 363 -----IQFEERSQSIQEHCSQQEKT-----IQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+Q + ++ + S+ E+T L+++ ++L T NNQ L Q
Sbjct: 434 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 493
Query: 413 NLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL 471
NL+ L + + + +TL ++ +E + E+ + + + ++K K E +
Sbjct: 494 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 552
Score = 50.8 bits (116), Expect = 2e-05
Identities = 97/404 (24%), Positives = 174/404 (43%), Gaps = 46/404 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V+ + ++ + Q + KQ+E N + Q Q + + T Q N + + +
Sbjct: 226 VERNNATLQAEKQALKTQLKQLETQNNNL-QTQILALQRQTVSLQEQNTT----LQTQNA 280
Query: 166 KLRINNTNCHTEHNAVQGTDAEKV---SAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
KL++ N+ +++ ++ +A+ + S++ N+ S I E E D+ + D + +L
Sbjct: 281 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KLE 339
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E R + E L S TL + LE+ H L N+ ++++ ++E
Sbjct: 340 LLHE----RQA---SEYESLISKHGTLKSAHKNLEVE--HRDLEDRYNQLLKQKGQLEDL 390
Query: 283 ALKTKLDEEKQAIISKCK--VDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
K+++EK + +K V E K N + +Q+LKE E L+ H L K
Sbjct: 391 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNL--K 447
Query: 340 EQEMKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+KLEQ E+ KLK Q + S + C + LE+E + L +
Sbjct: 448 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 507
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIE---EIKTLKDELIEKTIN----YE---- 447
QN L ++ N+++ KD E+ +I+ E++ K++L EK ++ Y+
Sbjct: 508 TLMLQNRTLLEQ--NMES-KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPP 564
Query: 448 -NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
N + L + K IK K + R+ LTL SDS
Sbjct: 565 RRRGNWITLKMRKLIKSKK------DINRERQKSLTLTPTRSDS 602
Score = 35.5 bits (78), Expect = 0.67
Identities = 68/339 (20%), Positives = 137/339 (40%), Gaps = 27/339 (7%)
Query: 378 QQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKD 437
Q EK + LE+E K L+ ++ + + ++ NL+ LS E + E LK+
Sbjct: 1 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 60
Query: 438 ------ELIEK-TINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR---- 486
EL+++ TI+ + V + +K + +T ++ + + R
Sbjct: 61 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 120
Query: 487 ---ESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKA 542
DS + LE +++ L + E+ E ++ + L + + ++ L + K+
Sbjct: 121 EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 180
Query: 543 AL--TKEHTRIMEHNVTLIESLQNVEKEAY---RELGTIKNELIE---DVELLKKESNSQ 594
AL ++ R+++ + + E+E+ REL +K+ LIE + L+ E +
Sbjct: 181 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA- 239
Query: 595 IKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENE--NERYXXXXX 652
+K +++E + + L A L ++EN N +
Sbjct: 240 LKTQLKQLETQNNNLQTQILALQRQTVSLQEQNTTLQTQNAKL-QVENSTLNSQSTSLMN 298
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ 691
L+++ S L ENE + S+ D L KD E+
Sbjct: 299 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 337
>L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein.
Length = 1300
Score = 70.9 bits (166), Expect = 1e-11
Identities = 93/455 (20%), Positives = 203/455 (44%), Gaps = 41/455 (9%)
Query: 184 TDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDL---- 238
T+ E+ + +I M+ RI LEK+ N+++ E ++ + VR+ + ++
Sbjct: 364 TEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
Query: 239 QEK-----LTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
QE SN E++Q E+ K A NE + K++ E ++ K + E+
Sbjct: 424 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKK-NAEQA 482
Query: 294 AIISKCKVDQENLK------------TKHNASIESLKNQMLKEKCEALEQLHSQL---II 338
A K ++ + + +H A+ + L+++ + ++ E ++ LHS+L ++
Sbjct: 483 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENE-VQSLHSKLTDTLV 541
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+Q+++ +L Q+ ES +++ E + + Q I E + IQ +I
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN-LAV 457
L + + ++ +K +D L++E+ + + LKD + + E KL LA
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN 659
Query: 458 EKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
E+A E K + S+ V D + +L +L+ E+ ++ ++L + L++E+
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQK 716
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
+ ++ + + E + ++ K K ++E + + + ++E + T
Sbjct: 717 LQTLVSEQPNK--DVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRT 770
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ L ++V+ LK + N Q+ F E K+V+ E
Sbjct: 771 ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
Score = 68.1 bits (159), Expect = 1e-10
Identities = 108/521 (20%), Positives = 227/521 (43%), Gaps = 52/521 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHN--------NIDFNEIDRKLSKLRINNTN 173
E NK +DY + +L E +L + Q N + E +R+ +++
Sbjct: 447 ELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK 506
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV-ITVRD 232
EH A Q K A N+++S +L + ++ + M+L E+ + +
Sbjct: 507 RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-KQQLEQRLMQLMESEQKRVNKEE 565
Query: 233 SLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE--SIRREYKIELEALKTKLDE 290
SL +Q+ L NE A+ QQ + + ++ A E + E +++ + L
Sbjct: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS 625
Query: 291 EKQAIISKCKV--DQENLKTKHNASIESLKNQMLKEKCEA--LEQLHSQLIIKEQEMKAK 346
E+ + SK + D +N+ A ++ L+ ++ A LE++ + +K+ +++
Sbjct: 626 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 347 LEQIEESASEKLKICEIQFEERS------QSIQEHCSQQ---------EKTIQYLEQEIK 391
EQ++ S K++ +I ++ Q +Q S+Q EK IQ ++++K
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE------LIEKTIN 445
++ L+ Q + ++ELN ++ L+ E ++++K +++ L+E+
Sbjct: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKE----VQDLKAKQNDQVSFASLVEELKK 801
Query: 446 YENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
+EK+ +VE+ ++ E K +D+ + L+E ++ + Q +TS
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA-LKEEIGNVQLEKAQQLSITS 860
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
+ L+N L K NT++ E KE K A K + E N +L +Q
Sbjct: 861 KVQELQN-LLKGKEEQMNTMKAVLEEKE------KDLANTGKWLQDLQEENESLKAHVQE 913
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
V + +E + E++E++ KE +++K L ++++
Sbjct: 914 VAQHNLKEASSASQ--FEELEIVLKEKENELKRLEAMLKER 952
Score = 67.3 bits (157), Expect = 2e-10
Identities = 98/510 (19%), Positives = 223/510 (43%), Gaps = 33/510 (6%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA- 145
+KK + KI +EL++A+ +++ NK++T+ + ++I+ K EI +Q E ++L+
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
Query: 146 -TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA----EKVSAMINDMRSRI 200
+K ++ N + E K + + D E + A + ++
Sbjct: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
Query: 201 IE---LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKD----LQEKLTSNELTLAETQ 253
++ + E L+ + +K+ EL LE ++ R+S LQ+ N+L ++ +
Sbjct: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
Query: 254 QRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
Q L+ A + +E + + E + E+ L +LD K A+ + K + E +
Sbjct: 979 Q-LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVE 1037
Query: 311 NASIESLK-NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERS 369
+E+ + + L K L + E KAK S SE++K+ E + +E
Sbjct: 1038 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1097
Query: 370 QS---IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEK 425
+ +Q C + + + E +++L+ +++ N+ + + +K + ++ +
Sbjct: 1098 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1157
Query: 426 FNFIEEIKTLKDELIEKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
+E++ L+ E K I N E+ L + +EKA E++ + T + + ++ +
Sbjct: 1158 ----QELERLRSE--NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1211
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
LR +E +++ + + E++++++ K + TV E + + K ++
Sbjct: 1212 LRTEQNERQKVAGDLHKAQQSLELIQSKIV--KAAGDTTVIENSDVSPETESSEKETMSV 1269
Query: 545 TKEHT-RIMEHNVTLIESLQNVEKEAYREL 573
+ T ++ + + EKE Y+ L
Sbjct: 1270 SLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1299
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 317 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 366
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + +I + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 367 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 427 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 482
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 483 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 536
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 537 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 593 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 627
Score = 32.7 bits (71), Expect = 4.7
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 326
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 327 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE 386
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 387 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 548
>D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein.
Length = 1388
Score = 70.9 bits (166), Expect = 1e-11
Identities = 115/510 (22%), Positives = 217/510 (42%), Gaps = 39/510 (7%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+T E +KQI+ ++ LQ+ K + + +F + L R + T+
Sbjct: 583 KTQAESSKQIQQLESNNRDLQD--KNCLLETAKLKLEKEFINLQSALESERRDRTHGSEI 640
Query: 178 HNAVQGTDAEKVSAMINDMRS-RI----IELEKKCEALDNEVYDKQMELSSLEEVITVRD 232
N +QG ++ + D+++ +I +ELEK+ L D + E S++E +T +
Sbjct: 641 INDLQG----RICGLEEDLKNGKILLAKVELEKR--QLQERFTDLEKEKSNMEIDMTYQ- 693
Query: 233 SLCKDLQEKLTSNELTLAETQQRL-EMVKGHHALALEANESIRREYK--IELEALKTK-- 287
K +Q+ L E T+ RL + K + ++ +E+++ K +E LK K
Sbjct: 694 --LKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVE 751
Query: 288 ---LDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+ EK+ + C + Q K + + N+ ++ +EQ + + + ++K
Sbjct: 752 NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLK 811
Query: 345 AKLEQIEE-SASEK-LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---- 398
+ +Q+ SEK LK E ++++ ++ K Q + ++KEL+ L+
Sbjct: 812 MQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQY 871
Query: 399 ---LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L Q +LK+E EL +K +E +L +L ++E+ ++
Sbjct: 872 FSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSI 931
Query: 456 AVEK-AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELT 514
A E+ + EK K L + ++++ L E D+ + LE+ + LTS L NE
Sbjct: 932 AEEQYSDLEKEKIMKELEI-KEMMARHKQELTEKDATIASLEETNRTLTSDVANLANE-- 988
Query: 515 TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELG 574
K LNN +++ E L + S AA+ + + + TL N E
Sbjct: 989 --KEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE 1046
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEK 604
+K DV +KE+ L+ E EK
Sbjct: 1047 PVKRGNDTDVRRKEKENRKLHMELKSEREK 1076
Score = 56.4 bits (130), Expect = 3e-07
Identities = 92/376 (24%), Positives = 168/376 (44%), Gaps = 76/376 (20%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSL---EEVIT--VRDSLCKDLQEK----LTSNELTLA 250
++E EK+C LD ++ Q +++ L ++V+ VR+ K QE LT N+L +
Sbjct: 754 LLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKM- 812
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTK- 309
+TQQ + L E N + E K+ LE +L +E+Q + K Q+ L+ +
Sbjct: 813 QTQQVNTLKMSEKQLKQENNHLM--EMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ 870
Query: 310 HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM----------------KAKLEQIEES 353
+ +++ + + LKE+CE +L +L K+QE+ KA EQ+ S
Sbjct: 871 YFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARS 930
Query: 354 ASE-------KLKIC-EIQFEERSQSIQEHCSQQEKTIQYLEQ-------EIKELKYTLD 398
+E K KI E++ +E ++ ++++ TI LE+ ++ L +
Sbjct: 931 IAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE 990
Query: 399 LTNNQNSDLKQELNNLKN-----------------CKDELSTEKFNFIEEIKTLKD---- 437
NN+ D++++L+ LK+ + L T+ N + EI K+
Sbjct: 991 ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKR 1050
Query: 438 ---------ELIEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + ++ E +E+ KL + K KE N+ + ++ I L + L
Sbjct: 1051 GNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLD 1110
Query: 487 ESDSELEQLEDQVQML 502
DS++EQL Q+Q L
Sbjct: 1111 SKDSDIEQLRSQLQAL 1126
Score = 54.0 bits (124), Expect = 2e-06
Identities = 62/291 (21%), Positives = 135/291 (46%), Gaps = 20/291 (6%)
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
C + + S+ + QE++ KL +EE S +++ E + E++ +S+ ++ EKT +
Sbjct: 428 CRENDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKE-ELEQKCKSVN---TRLEKTAKE 483
Query: 386 LEQEI---KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
LE+EI K ++ L + + L+ + + D + +K N ++ +LKD+L +
Sbjct: 484 LEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL--E 541
Query: 443 TINYENEKNKLNL-AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE----- 496
+ N+ ++++ V + ++ ++ L D L ES +++QLE
Sbjct: 542 DLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRD 601
Query: 497 --DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
D+ +L +AK LE E ++ L + R+ E ++N L+ + +E + +
Sbjct: 602 LQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSE-IINDLQGRICGLEEDLKNGKI 660
Query: 555 NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+ +E + +E + +L K+ + D+ K ++ +EE E K
Sbjct: 661 LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLE--QEEAEHK 709
Score = 52.8 bits (121), Expect = 4e-06
Identities = 104/520 (20%), Positives = 234/520 (45%), Gaps = 45/520 (8%)
Query: 202 ELEKKC----EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT---SNELTLAETQQ 254
E++KK E L NE+ K+ + V T + K+L+E++T S E L + ++
Sbjct: 444 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 503
Query: 255 R---LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ----AIISKCKVDQ-ENL 306
L+ + + +R + ++ +LK +L++ K+ + IS KV+Q +
Sbjct: 504 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQ 563
Query: 307 KTKHNASIESLKN---QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ NA + + + ++ K + E+ +Q+ QL ++++ K + E+A KL+ I
Sbjct: 564 LDETNALLRTESDTAARLRKTQAESSKQI-QQLESNNRDLQDK-NCLLETAKLKLEKEFI 621
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+ +S + + + I L+ I L+ L + ++ E L+ +L
Sbjct: 622 NLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEK 681
Query: 424 EKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR-DIVHVLT 482
EK N +E T + ++I++++ E ++K A + + +KNK S+ + + + +
Sbjct: 682 EKSN-MEIDMTYQLKVIQQSLEQEEAEHK---ATKARLADKNKIYESIEEAKSEAMKEME 737
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI-LK-- 539
+L E + +++E+ + +L+ +L + +N +++ D E + N+ LK
Sbjct: 738 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIE 797
Query: 540 ---SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE---SNS 593
K LT+ ++ V ++ + K+ L +K L + L+KE ++
Sbjct: 798 QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 857
Query: 594 QIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXX 653
Q+K L++++E ++ + L + L++E +
Sbjct: 858 QMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERD-------- 909
Query: 654 XXSLVVELSLLRQENEELTMTVA-KQSSIIDKLK--KDLE 690
+ +E++L + ++E+L ++A +Q S ++K K K+LE
Sbjct: 910 SLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELE 949
Score = 42.3 bits (95), Expect = 0.006
Identities = 76/341 (22%), Positives = 144/341 (42%), Gaps = 23/341 (6%)
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+ +++ +++EH S + + + LEQ+ K + L+ T + + ++++ +L
Sbjct: 444 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 503
Query: 424 EKF---NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + E + D +K N EN+ N L +E +K++N+ + ++ + V+
Sbjct: 504 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLED-LKKRNQ---NSQISTEKVNQ 559
Query: 481 LTLRLRESDSELEQLEDQVQML-----TSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
L +L E+++ L D L S+K++ + E N + E + K
Sbjct: 560 LQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK-LEK 618
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ ++AL E R H +I LQ +L K L+ VEL K++ Q
Sbjct: 619 EFINLQSALESER-RDRTHGSEIINDLQGRICGLEEDLKNGK-ILLAKVELEKRQ--LQE 674
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA--ADLSRL-ENENERYXXXXX 652
+F E EK + +M A A AD +++ E+ E
Sbjct: 675 RFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMK 734
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++E L+Q+ E L + K+ S++D DL+QSQ
Sbjct: 735 EMEKKLLEERTLKQKVENLLLEAEKRCSLLD---CDLKQSQ 772
Score = 40.3 bits (90), Expect = 0.024
Identities = 43/200 (21%), Positives = 83/200 (41%), Gaps = 9/200 (4%)
Query: 486 RESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT 545
+E +L LE+ + AKE LE + + L T +E +E + L ++S
Sbjct: 443 QEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEE-EITLRKSVESALRQL 501
Query: 546 KEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES-NSQIKFLREEVEK 604
+ +++H + + E + R L N L + +E LKK + NSQI E+V +
Sbjct: 502 EREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQIS--TEKVNQ 559
Query: 605 KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLL 664
+ + R A+++ + +LE+ N + ++E + L
Sbjct: 560 LQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR-----DLQDKNCLLETAKL 614
Query: 665 RQENEELTMTVAKQSSIIDK 684
+ E E + + A +S D+
Sbjct: 615 KLEKEFINLQSALESERRDR 634
>D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein.
Length = 1307
Score = 70.9 bits (166), Expect = 1e-11
Identities = 93/455 (20%), Positives = 203/455 (44%), Gaps = 41/455 (9%)
Query: 184 TDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDL---- 238
T+ E+ + +I M+ RI LEK+ N+++ E ++ + VR+ + ++
Sbjct: 371 TEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 430
Query: 239 QEK-----LTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
QE SN E++Q E+ K A NE + K++ E ++ K + E+
Sbjct: 431 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKK-NAEQA 489
Query: 294 AIISKCKVDQENLK------------TKHNASIESLKNQMLKEKCEALEQLHSQL---II 338
A K ++ + + +H A+ + L+++ + ++ E ++ LHS+L ++
Sbjct: 490 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENE-VQSLHSKLTDTLV 548
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+Q+++ +L Q+ ES +++ E + + Q I E + IQ +I
Sbjct: 549 SKQQLEQRLMQLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 607
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN-LAV 457
L + + ++ +K +D L++E+ + + LKD + + E KL LA
Sbjct: 608 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN 666
Query: 458 EKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
E+A E K + S+ V D + +L +L+ E+ ++ ++L + L++E+
Sbjct: 667 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQK 723
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
+ ++ + + E + ++ K K ++E + + + ++E + T
Sbjct: 724 LQTLVSEQPNK--DVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRT 777
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ L ++V+ LK + N Q+ F E K+V+ E
Sbjct: 778 ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 812
Score = 68.1 bits (159), Expect = 1e-10
Identities = 108/521 (20%), Positives = 227/521 (43%), Gaps = 52/521 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHN--------NIDFNEIDRKLSKLRINNTN 173
E NK +DY + +L E +L + Q N + E +R+ +++
Sbjct: 454 ELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK 513
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV-ITVRD 232
EH A Q K A N+++S +L + ++ + M+L E+ + +
Sbjct: 514 RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-KQQLEQRLMQLMESEQKRVNKEE 572
Query: 233 SLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE--SIRREYKIELEALKTKLDE 290
SL +Q+ L NE A+ QQ + + ++ A E + E +++ + L
Sbjct: 573 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS 632
Query: 291 EKQAIISKCKV--DQENLKTKHNASIESLKNQMLKEKCEA--LEQLHSQLIIKEQEMKAK 346
E+ + SK + D +N+ A ++ L+ ++ A LE++ + +K+ +++
Sbjct: 633 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 692
Query: 347 LEQIEESASEKLKICEIQFEERS------QSIQEHCSQQ---------EKTIQYLEQEIK 391
EQ++ S K++ +I ++ Q +Q S+Q EK IQ ++++K
Sbjct: 693 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 752
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE------LIEKTIN 445
++ L+ Q + ++ELN ++ L+ E ++++K +++ L+E+
Sbjct: 753 TVEELLETGLIQVATKEEELNAIRTENSSLTKE----VQDLKAKQNDQVSFASLVEELKK 808
Query: 446 YENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
+EK+ +VE+ ++ E K +D+ + L+E ++ + Q +TS
Sbjct: 809 VIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA-LKEEIGNVQLEKAQQLSITS 867
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
+ L+N L K NT++ E KE K A K + E N +L +Q
Sbjct: 868 KVQELQN-LLKGKEEQMNTMKAVLEEKE------KDLANTGKWLQDLQEENESLKAHVQE 920
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
V + +E + E++E++ KE +++K L ++++
Sbjct: 921 VAQHNLKEASSASQ--FEELEIVLKEKENELKRLEAMLKER 959
Score = 67.3 bits (157), Expect = 2e-10
Identities = 98/510 (19%), Positives = 223/510 (43%), Gaps = 33/510 (6%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA- 145
+KK + KI +EL++A+ +++ NK++T+ + ++I+ K EI +Q E ++L+
Sbjct: 806 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 865
Query: 146 -TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA----EKVSAMINDMRSRI 200
+K ++ N + E K + + D E + A + ++
Sbjct: 866 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 925
Query: 201 IE---LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKD----LQEKLTSNELTLAETQ 253
++ + E L+ + +K+ EL LE ++ R+S LQ+ N+L ++ +
Sbjct: 926 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 985
Query: 254 QRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
Q L+ A + +E + + E + E+ L +LD K A+ + K + E +
Sbjct: 986 Q-LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVE 1044
Query: 311 NASIESLK-NQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERS 369
+E+ + + L K L + E KAK S SE++K+ E + +E
Sbjct: 1045 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1104
Query: 370 QS---IQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEK 425
+ +Q C + + + E +++L+ +++ N+ + + +K + ++ +
Sbjct: 1105 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1164
Query: 426 FNFIEEIKTLKDELIEKTI-NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLR 484
+E++ L+ E K I N E+ L + +EKA E++ + T + + ++ +
Sbjct: 1165 ----QELERLRSE--NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1218
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
LR +E +++ + + E++++++ K + TV E + + K ++
Sbjct: 1219 LRTEQNERQKVAGDLHKAQQSLELIQSKIV--KAAGDTTVIENSDVSPETESSEKETMSV 1276
Query: 545 TKEHT-RIMEHNVTLIESLQNVEKEAYREL 573
+ T ++ + + EKE Y+ L
Sbjct: 1277 SLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1306
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 324 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 373
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + +I + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 374 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 433
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 434 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 489
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 490 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 543
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 544 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 599
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 600 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 634
Score = 32.7 bits (71), Expect = 4.7
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 279 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 333
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 334 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE 393
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 394 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 452
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 453 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 512
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 513 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 555
>BX537759-1|CAD97828.1| 1763|Homo sapiens hypothetical protein
protein.
Length = 1763
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFQERFQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQKRERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1152
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1153 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1211
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1272 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1387 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1437
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1495
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1496 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1527
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQKRERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>BX537708-1|CAD97819.1| 1605|Homo sapiens hypothetical protein
protein.
Length = 1605
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFQERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.0 bits (124), Expect = 2e-06
Identities = 116/539 (21%), Positives = 233/539 (43%), Gaps = 69/539 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFQERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVE 603
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREE 620
Score = 43.6 bits (98), Expect = 0.003
Identities = 71/358 (19%), Positives = 160/358 (44%), Gaps = 51/358 (14%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ + K L +D+ +Q + +++K++ + E N +IE A+ +E L++ T+
Sbjct: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
Query: 149 RQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCE 208
Q + + ++ + + N + T+ ++ I + + +L+++ E
Sbjct: 363 FQGSEDYETALSGKEALSAALRS------QNLTKSTENHRLRRSIKKITQELSDLQQERE 416
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
L+ ++ + E S + T+RD ++ EKL NE+ E ++ +E + +L E
Sbjct: 417 RLEKDLEEAHREKSKGD--CTIRD--LRNEVEKLR-NEVN--EREKAME--NRYKSLLSE 467
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISK-----CKVDQENLKTKHNASIESLKNQMLK 323
+N+ + + ++ ++ L T+ +K ++ K +V Q+N +E ++
Sbjct: 468 SNKKLHNQEQV-IKHL-TESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
EKC + + S+ I + E+ + S E+L IQ ++ Q I H
Sbjct: 526 EKCSSQQPPGSKTIFSK-------EKKQSSDYEEL----IQVLKKEQDIYTHL------- 567
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
+K L+ + D NN L+ ELN + + +L + ++ KTL++++ E
Sbjct: 568 ------VKSLQES-DSINN----LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISE 614
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 863 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 922
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 923 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 981
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 982 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1041
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1042 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1096
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1097 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1156
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1157 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1207
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1208 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1265
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1266 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1297
>BX537421-1|CAD97663.1| 1204|Homo sapiens hypothetical protein
protein.
Length = 1204
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFQERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFQERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>BC050555-1|AAH50555.1| 873|Homo sapiens KTN1 protein protein.
Length = 873
Score = 70.9 bits (166), Expect = 1e-11
Identities = 93/455 (20%), Positives = 203/455 (44%), Gaps = 41/455 (9%)
Query: 184 TDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDL---- 238
T+ E+ + +I M+ RI LEK+ N+++ E ++ + VR+ + ++
Sbjct: 364 TEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
Query: 239 QEK-----LTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
QE SN E++Q E+ K A NE + K++ E ++ K + E+
Sbjct: 424 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKK-NAEQA 482
Query: 294 AIISKCKVDQENLK------------TKHNASIESLKNQMLKEKCEALEQLHSQL---II 338
A K ++ + + +H A+ + L+++ + ++ E ++ LHS+L ++
Sbjct: 483 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENE-VQSLHSKLTDTLV 541
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+Q+++ +L Q+ ES +++ E + + Q I E + IQ +I
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN-LAV 457
L + + ++ +K +D L++E+ + + LKD + + E KL LA
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN 659
Query: 458 EKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
E+A E K + S+ V D + +L +L+ E+ ++ ++L + L++E+
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQK 716
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
+ ++ + + E + ++ K K ++E + + + ++E + T
Sbjct: 717 LQTLVSEQPNK--DVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRT 770
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ L ++V+ LK + N Q+ F E K+V+ E
Sbjct: 771 ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 317 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 366
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + +I + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 367 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 427 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 482
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 483 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 536
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 537 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 593 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 627
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/331 (22%), Positives = 148/331 (44%), Gaps = 33/331 (9%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
+L++++ + ++ + +E + AQ+Q+ ++A + S + +++ +
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAE 611
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
K +I T + T E+ I +M + +K +AL NE EL
Sbjct: 612 KDK-QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
+++ + V+D + L+E+L E ++E K + + N+++ K E++
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQH------EISNKMEEFK----ILNDQNKAL----KSEVQK 716
Query: 284 LKTKLDEE--KQAI--ISKCKVDQ-ENLKTKHNASIESLKNQMLKEK-CEALEQLHSQLI 337
L+T + E+ K + + KC ++ E LKT L KE+ A+ +S L
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 338 IKEQEMKAKLEQIEESAS--EKLKICEIQFEERSQSIQE-------HCSQQEKTIQYLEQ 388
+ Q++KAK AS E+LK + + + +S++E + +EKT+Q L+Q
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 389 EIKELKY---TLDLTNNQNSDLKQELNNLKN 416
EIK LK + L Q + ++ L+N
Sbjct: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQN 867
Score = 34.3 bits (75), Expect = 1.5
Identities = 15/51 (29%), Positives = 32/51 (62%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
+KK + KI +EL++A+ +++ NK++T+ + ++I+ K EI +Q
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ 849
Score = 32.7 bits (71), Expect = 4.7
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 326
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 327 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE 386
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 387 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 548
>AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1
protein.
Length = 1357
Score = 70.9 bits (166), Expect = 1e-11
Identities = 93/455 (20%), Positives = 203/455 (44%), Gaps = 41/455 (9%)
Query: 184 TDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDL---- 238
T+ E+ + +I M+ RI LEK+ N+++ E ++ + VR+ + ++
Sbjct: 364 TEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
Query: 239 QEK-----LTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
QE SN E++Q E+ K A NE + K++ E ++ K + E+
Sbjct: 424 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKK-NAEQA 482
Query: 294 AIISKCKVDQENLK------------TKHNASIESLKNQMLKEKCEALEQLHSQL---II 338
A K ++ + + +H A+ + L+++ + ++ E ++ LHS+L ++
Sbjct: 483 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENE-VQSLHSKLTDTLV 541
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+Q+++ +L Q+ ES +++ E + + Q I E + IQ +I
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN-LAV 457
L + + ++ +K +D L++E+ + + LKD + + E KL LA
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN 659
Query: 458 EKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
E+A E K + S+ V D + +L +L+ E+ ++ ++L + L++E+
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQK 716
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
+ ++ + + E + ++ K K ++E + + + ++E + T
Sbjct: 717 LQTLVSEQPNK--DVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRT 770
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ L ++V+ LK + N Q+ F E K+V+ E
Sbjct: 771 ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
Score = 68.9 bits (161), Expect = 6e-11
Identities = 119/566 (21%), Positives = 254/566 (44%), Gaps = 60/566 (10%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA- 145
+KK + KI +EL++A+ +++ NK++T+ + ++I+ K EI +Q E ++L+
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
Query: 146 -TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA----EKVSAMINDMRSRI 200
+K ++ N + E K + + D E + A + ++
Sbjct: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
Query: 201 IE---LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKD----LQEKLTSNELTLAETQ 253
++ + E L+ + +K+ EL LE ++ R+S LQ+ N+L ++ +
Sbjct: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
Query: 254 QRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
Q L+ A + +E + + E + E+ L +LD K A+ + K + + L+ K+
Sbjct: 979 Q-LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND-LREKN 1036
Query: 311 NASIESLKN--QMLKEKC-EALEQLHSQLIIKEQEMKAKLEQI--EESASEKLKICE--I 363
++E+L + +ML++K + ++ Q+ E E K L+++ + S L E
Sbjct: 1037 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKEL------------KY------TLDLTNNQNS 405
FE++++ S E+ ++ LE ++KE KY T +
Sbjct: 1097 GFEKKAKECMAGTSGSEE-VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 1155
Query: 406 DLKQELNNLKNCKDE----LSTEKFNFI---EEIKTLKDELIEKTI-NYENEKNKLNLAV 457
++QE N K DE + + +F +E++ L+ E K I N E+ L + +
Sbjct: 1156 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE--NKDIENLRREREHLEMEL 1213
Query: 458 EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK 517
EKA E++ + T + +D++ L +L +S SE + +++ +L + +L T +
Sbjct: 1214 EKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQ 1273
Query: 518 NTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK 577
N + + +++L +++SK T ++E N + ++ EKE +
Sbjct: 1274 NERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIE-NSDVSPETESSEKET---MSVSL 1328
Query: 578 NELIEDVELLKKESNSQIKFLREEVE 603
N+ + ++ L + N Q+ +E +
Sbjct: 1329 NQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
Score = 68.1 bits (159), Expect = 1e-10
Identities = 108/521 (20%), Positives = 227/521 (43%), Gaps = 52/521 (9%)
Query: 122 EYNKQIEDYKNEIAQLQEILKELATKFRQSHN--------NIDFNEIDRKLSKLRINNTN 173
E NK +DY + +L E +L + Q N + E +R+ +++
Sbjct: 447 ELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK 506
Query: 174 CHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV-ITVRD 232
EH A Q K A N+++S +L + ++ + M+L E+ + +
Sbjct: 507 RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-KQQLEQRLMQLMESEQKRVNKEE 565
Query: 233 SLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE--SIRREYKIELEALKTKLDE 290
SL +Q+ L NE A+ QQ + + ++ A E + E +++ + L
Sbjct: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS 625
Query: 291 EKQAIISKCKV--DQENLKTKHNASIESLKNQMLKEKCEA--LEQLHSQLIIKEQEMKAK 346
E+ + SK + D +N+ A ++ L+ ++ A LE++ + +K+ +++
Sbjct: 626 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 347 LEQIEESASEKLKICEIQFEERS------QSIQEHCSQQ---------EKTIQYLEQEIK 391
EQ++ S K++ +I ++ Q +Q S+Q EK IQ ++++K
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDE------LIEKTIN 445
++ L+ Q + ++ELN ++ L+ E ++++K +++ L+E+
Sbjct: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKE----VQDLKAKQNDQVSFASLVEELKK 801
Query: 446 YENEKNKLNLAVEKAIK-EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
+EK+ +VE+ ++ E K +D+ + L+E ++ + Q +TS
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA-LKEEIGNVQLEKAQQLSITS 860
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
+ L+N L K NT++ E KE K A K + E N +L +Q
Sbjct: 861 KVQELQN-LLKGKEEQMNTMKAVLEEKE------KDLANTGKWLQDLQEENESLKAHVQE 913
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
V + +E + E++E++ KE +++K L ++++
Sbjct: 914 VAQHNLKEASSASQ--FEELEIVLKEKENELKRLEAMLKER 952
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 317 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 366
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + +I + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 367 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 427 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 482
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 483 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 536
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 537 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 593 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 627
Score = 32.7 bits (71), Expect = 4.7
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 326
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 327 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE 386
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 387 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 548
>AL590642-2|CAH70770.1| 862|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 862
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 43.6 bits (98), Expect = 0.003
Identities = 71/358 (19%), Positives = 160/358 (44%), Gaps = 51/358 (14%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ + K L +D+ +Q + +++K++ + E N +IE A+ +E L++ T+
Sbjct: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
Query: 149 RQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCE 208
Q + + ++ + + N + T+ ++ I + + +L+++ E
Sbjct: 363 FQGSEDYETALSGKEALSAALRS------QNLTKSTENHRLRRSIKKITQELSDLQQERE 416
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
L+ ++ + E S + T+RD ++ EKL NE+ E ++ +E + +L E
Sbjct: 417 RLEKDLEEAHREKSKGD--CTIRD--LRNEVEKLR-NEVN--EREKAME--NRYKSLLSE 467
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISK-----CKVDQENLKTKHNASIESLKNQMLK 323
+N+ + + ++ ++ L T+ +K ++ K +V Q+N +E ++
Sbjct: 468 SNKKLHNQEQV-IKHL-TESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
EKC + + S+ I + E+ + S E+L IQ ++ Q I H
Sbjct: 526 EKCSSQQPPGSKTIFSK-------EKKQSSDYEEL----IQVLKKEQDIYTHL------- 567
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
+K L+ + D NN L+ ELN + + +L + ++ KTL++++ E
Sbjct: 568 ------VKSLQES-DSINN----LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISE 614
Score = 33.9 bits (74), Expect = 2.0
Identities = 54/277 (19%), Positives = 114/277 (41%), Gaps = 11/277 (3%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYT 396
I EE ++ EH SQ+E K + L Q +KEL YT
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT 669
>AL590642-1|CAH70769.1| 1893|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 1893
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1152
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1153 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1211
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1272 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1387 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1437
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1495
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1496 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1527
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>AL391870-2|CAI40925.1| 1893|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 1893
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1152
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1153 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1211
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1272 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1387 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1437
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1495
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1496 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1527
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>AL391870-1|CAI40926.1| 862|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 862
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 43.6 bits (98), Expect = 0.003
Identities = 71/358 (19%), Positives = 160/358 (44%), Gaps = 51/358 (14%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ + K L +D+ +Q + +++K++ + E N +IE A+ +E L++ T+
Sbjct: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
Query: 149 RQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCE 208
Q + + ++ + + N + T+ ++ I + + +L+++ E
Sbjct: 363 FQGSEDYETALSGKEALSAALRS------QNLTKSTENHRLRRSIKKITQELSDLQQERE 416
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
L+ ++ + E S + T+RD ++ EKL NE+ E ++ +E + +L E
Sbjct: 417 RLEKDLEEAHREKSKGD--CTIRD--LRNEVEKLR-NEVN--EREKAME--NRYKSLLSE 467
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISK-----CKVDQENLKTKHNASIESLKNQMLK 323
+N+ + + ++ ++ L T+ +K ++ K +V Q+N +E ++
Sbjct: 468 SNKKLHNQEQV-IKHL-TESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
EKC + + S+ I + E+ + S E+L IQ ++ Q I H
Sbjct: 526 EKCSSQQPPGSKTIFSK-------EKKQSSDYEEL----IQVLKKEQDIYTHL------- 567
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
+K L+ + D NN L+ ELN + + +L + ++ KTL++++ E
Sbjct: 568 ------VKSLQES-DSINN----LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISE 614
Score = 33.9 bits (74), Expect = 2.0
Identities = 54/277 (19%), Positives = 114/277 (41%), Gaps = 11/277 (3%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYT 396
I EE ++ EH SQ+E K + L Q +KEL YT
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT 669
>AL353736-2|CAI40654.1| 862|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 862
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 43.6 bits (98), Expect = 0.003
Identities = 71/358 (19%), Positives = 160/358 (44%), Gaps = 51/358 (14%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ + K L +D+ +Q + +++K++ + E N +IE A+ +E L++ T+
Sbjct: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
Query: 149 RQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCE 208
Q + + ++ + + N + T+ ++ I + + +L+++ E
Sbjct: 363 FQGSEDYETALSGKEALSAALRS------QNLTKSTENHRLRRSIKKITQELSDLQQERE 416
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
L+ ++ + E S + T+RD ++ EKL NE+ E ++ +E + +L E
Sbjct: 417 RLEKDLEEAHREKSKGD--CTIRD--LRNEVEKLR-NEVN--EREKAME--NRYKSLLSE 467
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISK-----CKVDQENLKTKHNASIESLKNQMLK 323
+N+ + + ++ ++ L T+ +K ++ K +V Q+N +E ++
Sbjct: 468 SNKKLHNQEQV-IKHL-TESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
EKC + + S+ I + E+ + S E+L IQ ++ Q I H
Sbjct: 526 EKCSSQQPPGSKTIFSK-------EKKQSSDYEEL----IQVLKKEQDIYTHL------- 567
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
+K L+ + D NN L+ ELN + + +L + ++ KTL++++ E
Sbjct: 568 ------VKSLQES-DSINN----LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISE 614
Score = 33.9 bits (74), Expect = 2.0
Identities = 54/277 (19%), Positives = 114/277 (41%), Gaps = 11/277 (3%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYT 396
I EE ++ EH SQ+E K + L Q +KEL YT
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT 669
>AL353736-1|CAI40653.1| 1893|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 1893
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1152
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1153 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1211
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1272 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1387 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1437
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1495
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1496 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1527
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>AL138836-2|CAI16963.1| 1893|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 1893
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1152
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1153 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1211
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1272 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1387 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1437
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1495
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1496 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1527
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>AL138836-1|CAI16964.1| 862|Homo sapiens CDK5 regulatory subunit
associated protein 2 protein.
Length = 862
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 43.6 bits (98), Expect = 0.003
Identities = 71/358 (19%), Positives = 160/358 (44%), Gaps = 51/358 (14%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
++ + K L +D+ +Q + +++K++ + E N +IE A+ +E L++ T+
Sbjct: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
Query: 149 RQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCE 208
Q + + ++ + + N + T+ ++ I + + +L+++ E
Sbjct: 363 FQGSEDYETALSGKEALSAALRS------QNLTKSTENHRLRRSIKKITQELSDLQQERE 416
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
L+ ++ + E S + T+RD ++ EKL NE+ E ++ +E + +L E
Sbjct: 417 RLEKDLEEAHREKSKGD--CTIRD--LRNEVEKLR-NEVN--EREKAME--NRYKSLLSE 467
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISK-----CKVDQENLKTKHNASIESLKNQMLK 323
+N+ + + ++ ++ L T+ +K ++ K +V Q+N +E ++
Sbjct: 468 SNKKLHNQEQV-IKHL-TESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
Query: 324 EKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI 383
EKC + + S+ I + E+ + S E+L IQ ++ Q I H
Sbjct: 526 EKCSSQQPPGSKTIFSK-------EKKQSSDYEEL----IQVLKKEQDIYTHL------- 567
Query: 384 QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE 441
+K L+ + D NN L+ ELN + + +L + ++ KTL++++ E
Sbjct: 568 ------VKSLQES-DSINN----LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISE 614
Score = 33.9 bits (74), Expect = 2.0
Identities = 54/277 (19%), Positives = 114/277 (41%), Gaps = 11/277 (3%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYT 396
I EE ++ EH SQ+E K + L Q +KEL YT
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT 669
>AF448860-1|AAP41926.1| 1893|Homo sapiens hypothetical protein
protein.
Length = 1893
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 105 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 223
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 224 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 343 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 400 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 110 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 165
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 214
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 215 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 270
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 271 ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 328
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 447
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 566
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 567 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 621
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1152
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1153 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1211
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1272 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1387 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1437
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1495
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1496 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1527
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 399 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 456
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 457 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 516
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 517 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 575
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 576 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 634 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 686
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 687 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 740
>AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein.
Length = 1337
Score = 70.9 bits (166), Expect = 1e-11
Identities = 115/510 (22%), Positives = 217/510 (42%), Gaps = 39/510 (7%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+T E +KQI+ ++ LQ+ K + + +F + L R + T+
Sbjct: 532 KTQAESSKQIQQLESNNRDLQD--KNCLLETAKLKLEKEFINLQSALESERRDRTHGSEI 589
Query: 178 HNAVQGTDAEKVSAMINDMRS-RI----IELEKKCEALDNEVYDKQMELSSLEEVITVRD 232
N +QG ++ + D+++ +I +ELEK+ L D + E S++E +T +
Sbjct: 590 INDLQG----RICGLEEDLKNGKILLAKVELEKR--QLQERFTDLEKEKSNMEIDMTYQ- 642
Query: 233 SLCKDLQEKLTSNELTLAETQQRL-EMVKGHHALALEANESIRREYK--IELEALKTK-- 287
K +Q+ L E T+ RL + K + ++ +E+++ K +E LK K
Sbjct: 643 --LKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVE 700
Query: 288 ---LDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+ EK+ + C + Q K + + N+ ++ +EQ + + + ++K
Sbjct: 701 NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLK 760
Query: 345 AKLEQIEE-SASEK-LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---- 398
+ +Q+ SEK LK E ++++ ++ K Q + ++KEL+ L+
Sbjct: 761 MQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQY 820
Query: 399 ---LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L Q +LK+E EL +K +E +L +L ++E+ ++
Sbjct: 821 FSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSI 880
Query: 456 AVEK-AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELT 514
A E+ + EK K L + ++++ L E D+ + LE+ + LTS L NE
Sbjct: 881 AEEQYSDLEKEKIMKELEI-KEMMARHKQELTEKDATIASLEETNRTLTSDVANLANE-- 937
Query: 515 TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELG 574
K LNN +++ E L + S AA+ + + + TL N E
Sbjct: 938 --KEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE 995
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEK 604
+K DV +KE+ L+ E EK
Sbjct: 996 PVKRGNDTDVRRKEKENRKLHMELKSEREK 1025
Score = 56.4 bits (130), Expect = 3e-07
Identities = 104/533 (19%), Positives = 241/533 (45%), Gaps = 44/533 (8%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT- 243
+ + + + N+++ ++ LE E L NE+ K+ + V T + K+L+E++T
Sbjct: 383 ETDSIQSRKNEIQKKLYTLE---EHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL 439
Query: 244 --SNELTLAETQQR---LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ----A 294
S E L + ++ L+ + + +R + ++ +LK +L++ K+ +
Sbjct: 440 RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 499
Query: 295 IISKCKVDQ-ENLKTKHNASIESLKN---QMLKEKCEALEQLHSQLIIKEQEMKAKLEQI 350
IS KV+Q + + NA + + + ++ K + E+ +Q+ QL ++++ K +
Sbjct: 500 QISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQI-QQLESNNRDLQDK-NCL 557
Query: 351 EESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE 410
E+A KL+ I + +S + + + I L+ I L+ L + ++ E
Sbjct: 558 LETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELE 617
Query: 411 LNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETS 470
L+ +L EK N +E T + ++I++++ E ++K A + + +KNK S
Sbjct: 618 KRQLQERFTDLEKEKSN-MEIDMTYQLKVIQQSLEQEEAEHK---ATKARLADKNKIYES 673
Query: 471 LSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDE 529
+ + + + + +L E + +++E+ + +L+ +L + +N +++ D
Sbjct: 674 IEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV 733
Query: 530 YKEALVNI-LK-----SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIED 583
E + N+ LK K LT+ ++ V ++ + K+ L +K L +
Sbjct: 734 LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ 793
Query: 584 VELLKKE---SNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
L+KE ++ Q+K L++++E ++ + L + L
Sbjct: 794 NAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQEL 853
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTVA-KQSSIIDKLK--KDLE 690
++E + + +E++L + ++E+L ++A +Q S ++K K K+LE
Sbjct: 854 QDERD--------SLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELE 898
Score = 56.4 bits (130), Expect = 3e-07
Identities = 92/376 (24%), Positives = 168/376 (44%), Gaps = 76/376 (20%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSL---EEVIT--VRDSLCKDLQEK----LTSNELTLA 250
++E EK+C LD ++ Q +++ L ++V+ VR+ K QE LT N+L +
Sbjct: 703 LLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKM- 761
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTK- 309
+TQQ + L E N + E K+ LE +L +E+Q + K Q+ L+ +
Sbjct: 762 QTQQVNTLKMSEKQLKQENNHLM--EMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ 819
Query: 310 HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM----------------KAKLEQIEES 353
+ +++ + + LKE+CE +L +L K+QE+ KA EQ+ S
Sbjct: 820 YFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARS 879
Query: 354 ASE-------KLKIC-EIQFEERSQSIQEHCSQQEKTIQYLEQ-------EIKELKYTLD 398
+E K KI E++ +E ++ ++++ TI LE+ ++ L +
Sbjct: 880 IAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE 939
Query: 399 LTNNQNSDLKQELNNLKN-----------------CKDELSTEKFNFIEEIKTLKD---- 437
NN+ D++++L+ LK+ + L T+ N + EI K+
Sbjct: 940 ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKR 999
Query: 438 ---------ELIEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + ++ E +E+ KL + K KE N+ + ++ I L + L
Sbjct: 1000 GNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLD 1059
Query: 487 ESDSELEQLEDQVQML 502
DS++EQL Q+Q L
Sbjct: 1060 SKDSDIEQLRSQLQAL 1075
Score = 42.3 bits (95), Expect = 0.006
Identities = 76/341 (22%), Positives = 144/341 (42%), Gaps = 23/341 (6%)
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+ +++ +++EH S + + + LEQ+ K + L+ T + + ++++ +L
Sbjct: 393 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 452
Query: 424 EKF---NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + E + D +K N EN+ N L +E +K++N+ + ++ + V+
Sbjct: 453 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLED-LKKRNQ---NSQISTEKVNQ 508
Query: 481 LTLRLRESDSELEQLEDQVQML-----TSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
L +L E+++ L D L S+K++ + E N + E + K
Sbjct: 509 LQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK-LEK 567
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ ++AL E R H +I LQ +L K L+ VEL K++ Q
Sbjct: 568 EFINLQSALESER-RDRTHGSEIINDLQGRICGLEEDLKNGK-ILLAKVELEKRQ--LQE 623
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA--ADLSRL-ENENERYXXXXX 652
+F E EK + +M A A AD +++ E+ E
Sbjct: 624 RFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMK 683
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++E L+Q+ E L + K+ S++D DL+QSQ
Sbjct: 684 EMEKKLLEERTLKQKVENLLLEAEKRCSLLD---CDLKQSQ 721
>AB046853-1|BAB13459.2| 1852|Homo sapiens KIAA1633 protein protein.
Length = 1852
Score = 70.9 bits (166), Expect = 1e-11
Identities = 81/349 (23%), Positives = 162/349 (46%), Gaps = 24/349 (6%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E K+E+E+LK +L E +Q +I K E+L + I+ +K K+ + + L +
Sbjct: 143 ELKVEVESLKRELQEREQLLIKASKA-VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 201
Query: 336 LIIKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQE-HCSQQEKTIQYLEQE--I 390
+++ E+++ A ++E++ +E K ++ E + +++ H + E++ I
Sbjct: 202 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI 261
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDE--LSTEKFNFIEEIKTLKDELIEKT-INYE 447
+ELK +L LK+E + + C DE S E + K+ E + ++
Sbjct: 262 EELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAAPREEKERETEAAQMEHQ 320
Query: 448 NEKNKLN---LAVEKAIKEKNK---FETSLSVTRD-IVHVLTLRLRESDSELEQLEDQVQ 500
E+N A+E+ ++EK + E S+ RD + LT+ L+ + ++E+L +++
Sbjct: 321 KERNSFQERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 380
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L++A L + + ++Y+ AL AAL ++ N L
Sbjct: 381 KLSAAFAKAREAL---QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 437
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEKKR 606
S++ + +E +L + L +D+E +E + I+ LR EVEK R
Sbjct: 438 SIKKITQE-LSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 485
Score = 54.4 bits (125), Expect = 1e-06
Identities = 116/540 (21%), Positives = 234/540 (43%), Gaps = 69/540 (12%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V++ E++ ++Q + + +K +E + +KE A K Q ++ + +++
Sbjct: 148 VESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----LTKRIL 203
Query: 166 KLRINNTNCHTE-HNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
L + T E A GT+ EK A+ + S++ E++K E D M L
Sbjct: 204 LLEKDVTAAQAELEKAFAGTETEK--ALRLRLESKLSEMKKMHEG------DLAMAL--- 252
Query: 225 EEVITVRDSLCKDLQEKLTSNELT---LAETQQRL----EMVKGHHALALEANESIRREY 277
V+ +D L ++L+ L S E L E + ++ E V L A + R E
Sbjct: 253 --VLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCA--APREEK 308
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
+ E EA + + +E+ + + + +E+L+ K KN + ++K A++ L L
Sbjct: 309 ERETEAAQMEHQKERNSFQERIQALEEDLREKEREIATEKKNSLKRDK--AIQGLTMALK 366
Query: 338 IKE---QEMKAKLEQIEES---ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ--- 388
KE +E+ +++E++ + A E L+ + Q + S+ + S +E L
Sbjct: 367 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 426
Query: 389 ----EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI 444
E L+ ++ + SDL+QE L+ +E EK I+ L++E +EK
Sbjct: 427 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE-VEKLR 485
Query: 445 NYENEKNKL------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQ 498
N NE+ K +L E K N+ + +T L + ++ +LE ++
Sbjct: 486 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 545
Query: 499 VQMLTSAKEVLENE-LTT----------YKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
++ + L +E L T K + ++ +Y+E L+ +LK + +
Sbjct: 546 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEE-LIQVLKKEQDIYTH 604
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV---ELLKKESNSQIKFLREEVEK 604
+ ++ + +S+ N++ E ++ ++ +L +DV + L+K QI +R E+
Sbjct: 605 LVKSLQES----DSINNLQAE-LNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEE 659
Score = 38.3 bits (85), Expect = 0.095
Identities = 93/458 (20%), Positives = 187/458 (40%), Gaps = 54/458 (11%)
Query: 180 AVQGTDAEKVSAMIND---MRSRIIELEKKCEALDNEVYDKQMELSSLEEVITV------ 230
+V GTD + N+ ++ +I +LE + E N ++ Q E +ITV
Sbjct: 1131 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEG 1190
Query: 231 -RDSLCKDLQEKLTSNELTLAETQQ--RLEMVKGHHALALEANES-IRREYKIELEALKT 286
+D L K + E+T + Q ++ VK LA E +S + K +LE +
Sbjct: 1191 AQDGLSKP-KNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY 1249
Query: 287 KLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL---HSQLIIKE 340
KL +E+ + S+ Q + +SL +E +Q+ H +I
Sbjct: 1250 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1309
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
Q M ++ E E L+ ++ + ++ QE +Q + ++ LE+ K
Sbjct: 1310 QHMNTMIKAFE----ELLQASDVDYCV-AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1364
Query: 401 NNQNSDLKQ-ELNNLKN---CKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
N QN +++ E +NL + + + + +T + + +NE K ++
Sbjct: 1365 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1424
Query: 457 VEKAIKEKNKFETSLSVTR-DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
V N F L + + L RL ES E+L Q++ E ++ +
Sbjct: 1425 V-------NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE--RQGSEFVQGSTSI 1475
Query: 516 Y------KNTLNNTVRECDEYKEAL-VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
+ ++L + + + +AL ++K KE+ ++ E SL++++
Sbjct: 1476 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ-- 1533
Query: 569 AYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
RE ++K E+ E L+KE + + + ++ +++ R
Sbjct: 1534 --REYASVK----EENERLQKEGSEKERHNQQLIQEVR 1565
Score = 37.1 bits (82), Expect = 0.22
Identities = 68/355 (19%), Positives = 146/355 (41%), Gaps = 20/355 (5%)
Query: 125 KQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGT 184
+ I+ E++ LQ+ + L ++H + ++ D + LR E N +
Sbjct: 437 RSIKKITQELSDLQQERERLEKDLEEAHR--EKSKGDCTIRDLRNEVEKLRNEVNEREKA 494
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEE--VITVRDSLCKDLQEKL 242
+ +++++ ++ E+ + L K + L E + ++ + E L
Sbjct: 495 MENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL 554
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVD 302
L + + G + + + +Y+ ++ LK + D + S + D
Sbjct: 555 ELRSEGLITEKCSSQQPPGSKTIFSKEKKQ-SSDYEELIQVLKKEQDIYTHLVKSLQESD 613
Query: 303 Q-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
NL+ + N I +L+ Q L++ + + L L + E++ + E+ S++
Sbjct: 614 SINNLQAELN-KIFALRKQ-LEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 671
Query: 362 EIQFEERSQSIQEHCSQQE--KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK--NC 417
I EE ++ EH SQ+E K + L Q +KEL YT N LK+ + +L
Sbjct: 672 SICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL-YT------DNQHLKKTIFDLSCMGF 724
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ ++ E+ + L + E TI E +++N ++ +++ N+ LS
Sbjct: 725 QGNGFPDRLASTEQTELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNEIMKDLS 778
>AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein.
Length = 1428
Score = 70.9 bits (166), Expect = 1e-11
Identities = 115/510 (22%), Positives = 217/510 (42%), Gaps = 39/510 (7%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+T E +KQI+ ++ LQ+ K + + +F + L R + T+
Sbjct: 623 KTQAESSKQIQQLESNNRDLQD--KNCLLETAKLKLEKEFINLQSALESERRDRTHGSEI 680
Query: 178 HNAVQGTDAEKVSAMINDMRS-RI----IELEKKCEALDNEVYDKQMELSSLEEVITVRD 232
N +QG ++ + D+++ +I +ELEK+ L D + E S++E +T +
Sbjct: 681 INDLQG----RICGLEEDLKNGKILLAKVELEKR--QLQERFTDLEKEKSNMEIDMTYQ- 733
Query: 233 SLCKDLQEKLTSNELTLAETQQRL-EMVKGHHALALEANESIRREYK--IELEALKTK-- 287
K +Q+ L E T+ RL + K + ++ +E+++ K +E LK K
Sbjct: 734 --LKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVE 791
Query: 288 ---LDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMK 344
L+ EK+ + C + Q K + + N+ ++ +EQ + + + ++K
Sbjct: 792 NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLK 851
Query: 345 AKLEQIEE-SASEK-LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD---- 398
+ +Q+ SEK LK E ++++ ++ K Q + ++KEL+ L+
Sbjct: 852 MQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQY 911
Query: 399 ---LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNL 455
L Q +LK+E EL +K +E +L +L ++E+ ++
Sbjct: 912 FSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSI 971
Query: 456 AVEK-AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELT 514
A E+ + EK K L + ++++ L E D+ + LE+ + LTS L NE
Sbjct: 972 AEEQYSDLEKEKIMKELEI-KEMMARHKQELTEKDATIASLEETNRTLTSDVANLANE-- 1028
Query: 515 TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELG 574
K LNN +++ E L + S AA+ + + + TL N E
Sbjct: 1029 --KEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE 1086
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEK 604
+K DV +KE+ L+ E EK
Sbjct: 1087 PVKRGNDTDVRRKEKENRKLHMELKSEREK 1116
Score = 56.4 bits (130), Expect = 3e-07
Identities = 92/376 (24%), Positives = 168/376 (44%), Gaps = 76/376 (20%)
Query: 200 IIELEKKCEALDNEVYDKQMELSSL---EEVIT--VRDSLCKDLQEK----LTSNELTLA 250
++E EK+C LD ++ Q +++ L ++V+ VR+ K QE LT N+L +
Sbjct: 794 LLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKM- 852
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTK- 309
+TQQ + L E N + E K+ LE +L +E+Q + K Q+ L+ +
Sbjct: 853 QTQQVNTLKMSEKQLKQENNHLM--EMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ 910
Query: 310 HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM----------------KAKLEQIEES 353
+ +++ + + LKE+CE +L +L K+QE+ KA EQ+ S
Sbjct: 911 YFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARS 970
Query: 354 ASE-------KLKIC-EIQFEERSQSIQEHCSQQEKTIQYLEQ-------EIKELKYTLD 398
+E K KI E++ +E ++ ++++ TI LE+ ++ L +
Sbjct: 971 IAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE 1030
Query: 399 LTNNQNSDLKQELNNLKN-----------------CKDELSTEKFNFIEEIKTLKD---- 437
NN+ D++++L+ LK+ + L T+ N + EI K+
Sbjct: 1031 ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKR 1090
Query: 438 ---------ELIEKTINYE--NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLR 486
E + ++ E +E+ KL + K KE N+ + ++ I L + L
Sbjct: 1091 GNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLD 1150
Query: 487 ESDSELEQLEDQVQML 502
DS++EQL Q+Q L
Sbjct: 1151 SKDSDIEQLRSQLQAL 1166
Score = 54.0 bits (124), Expect = 2e-06
Identities = 62/291 (21%), Positives = 135/291 (46%), Gaps = 20/291 (6%)
Query: 326 CEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
C + + S+ + QE++ KL +EE S +++ E + E++ +S+ ++ EKT +
Sbjct: 468 CRENDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKE-ELEQKCKSVN---TRLEKTAKE 523
Query: 386 LEQEI---KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
LE+EI K ++ L + + L+ + + D + +K N ++ +LKD+L +
Sbjct: 524 LEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL--E 581
Query: 443 TINYENEKNKLNL-AVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE----- 496
+ N+ ++++ V + ++ ++ L D L ES +++QLE
Sbjct: 582 DLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRD 641
Query: 497 --DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
D+ +L +AK LE E ++ L + R+ E ++N L+ + +E + +
Sbjct: 642 LQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSE-IINDLQGRICGLEEDLKNGKI 700
Query: 555 NVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
+ +E + +E + +L K+ + D+ K ++ +EE E K
Sbjct: 701 LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLE--QEEAEHK 749
Score = 52.8 bits (121), Expect = 4e-06
Identities = 104/520 (20%), Positives = 234/520 (45%), Gaps = 45/520 (8%)
Query: 202 ELEKKC----EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLT---SNELTLAETQQ 254
E++KK E L NE+ K+ + V T + K+L+E++T S E L + ++
Sbjct: 484 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 543
Query: 255 R---LEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ----AIISKCKVDQ-ENL 306
L+ + + +R + ++ +LK +L++ K+ + IS KV+Q +
Sbjct: 544 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQ 603
Query: 307 KTKHNASIESLKN---QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
+ NA + + + ++ K + E+ +Q+ QL ++++ K + E+A KL+ I
Sbjct: 604 LDETNALLRTESDTAARLRKTQAESSKQI-QQLESNNRDLQDK-NCLLETAKLKLEKEFI 661
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+ +S + + + I L+ I L+ L + ++ E L+ +L
Sbjct: 662 NLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEK 721
Query: 424 EKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR-DIVHVLT 482
EK N +E T + ++I++++ E ++K A + + +KNK S+ + + + +
Sbjct: 722 EKSN-MEIDMTYQLKVIQQSLEQEEAEHK---ATKARLADKNKIYESIEEAKSEAMKEME 777
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI-LK-- 539
+L E + +++E+ + +L+ +L + +N +++ D E + N+ LK
Sbjct: 778 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIE 837
Query: 540 ---SKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE---SNS 593
K LT+ ++ V ++ + K+ L +K L + L+KE ++
Sbjct: 838 QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 897
Query: 594 QIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXX 653
Q+K L++++E ++ + L + L++E +
Sbjct: 898 QMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERD-------- 949
Query: 654 XXSLVVELSLLRQENEELTMTVA-KQSSIIDKLK--KDLE 690
+ +E++L + ++E+L ++A +Q S ++K K K+LE
Sbjct: 950 SLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELE 989
Score = 42.3 bits (95), Expect = 0.006
Identities = 76/341 (22%), Positives = 144/341 (42%), Gaps = 23/341 (6%)
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
+ +++ +++EH S + + + LEQ+ K + L+ T + + ++++ +L
Sbjct: 484 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 543
Query: 424 EKF---NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV 480
EK + E + D +K N EN+ N L +E +K++N+ + ++ + V+
Sbjct: 544 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLED-LKKRNQ---NSQISTEKVNQ 599
Query: 481 LTLRLRESDSELEQLEDQVQML-----TSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
L +L E+++ L D L S+K++ + E N + E + K
Sbjct: 600 LQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK-LEK 658
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ ++AL E R H +I LQ +L K L+ VEL K++ Q
Sbjct: 659 EFINLQSALESER-RDRTHGSEIINDLQGRICGLEEDLKNGK-ILLAKVELEKRQ--LQE 714
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAA--ADLSRL-ENENERYXXXXX 652
+F E EK + +M A A AD +++ E+ E
Sbjct: 715 RFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMK 774
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++E L+Q+ E L + K+ S++D DL+QSQ
Sbjct: 775 EMEKKLLEERTLKQKVENLLLEAEKRCSLLD---CDLKQSQ 812
Score = 40.3 bits (90), Expect = 0.024
Identities = 43/200 (21%), Positives = 83/200 (41%), Gaps = 9/200 (4%)
Query: 486 RESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT 545
+E +L LE+ + AKE LE + + L T +E +E + L ++S
Sbjct: 483 QEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEE-EITLRKSVESALRQL 541
Query: 546 KEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES-NSQIKFLREEVEK 604
+ +++H + + E + R L N L + +E LKK + NSQI E+V +
Sbjct: 542 EREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQIS--TEKVNQ 599
Query: 605 KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLL 664
+ + R A+++ + +LE+ N + ++E + L
Sbjct: 600 LQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR-----DLQDKNCLLETAKL 654
Query: 665 RQENEELTMTVAKQSSIIDK 684
+ E E + + A +S D+
Sbjct: 655 KLEKEFINLQSALESERRDR 674
>BC117132-1|AAI17133.1| 1306|Homo sapiens kinectin 1 (kinesin
receptor) protein.
Length = 1306
Score = 70.5 bits (165), Expect = 2e-11
Identities = 111/529 (20%), Positives = 236/529 (44%), Gaps = 45/529 (8%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR--- 168
EI NK + N Q + K+E+ +LQ ++ E K E D KL +
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
Query: 169 ----INNTNCHTEHNAVQGTDAEKVSAMINDMRSRI---IELEKKCEALDNEVYDKQMEL 221
I E NA++ T+ ++ + D++++ + E L +++K ++
Sbjct: 752 ETGLIQVATKEEELNAIR-TENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI 810
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S+EE++ L K ++ T ++ Q+ ++KG + +++ E + +L
Sbjct: 811 KSVEELLEAE--LLKVANKEKTVQLSITSKVQELQNLLKGKEE-QMNTMKAVLEEKEKDL 867
Query: 282 EALKT---KLDEEKQAIISKCK-VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
L EE +++ + + V Q NLK +AS +LKEK L++L + L
Sbjct: 868 ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 927
Query: 338 IKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSIQEHCS--QQEKTIQYLEQEIKELK 394
+E ++ +K + +++ E K+ + Q E+ + Q+ Q+ S E+ ++ + + KE+
Sbjct: 928 ERESDLSSKTQLLQDVQDEN-KLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS 986
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
L N +S LK + + + ++L + + +E + + + L +K E+ +
Sbjct: 987 ---GLWNELDS-LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1042
Query: 455 LAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE---VLE 510
AVE KE K +SV ++ + L E+ + TS E VLE
Sbjct: 1043 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLH------GFEKKAKECMAGTSGSEEVKVLE 1096
Query: 511 NELTTYKNTLNNTVRECDEYKEALVN----ILKSKAALTKEHTR---IMEHNVTLIESLQ 563
++L EC++YK L + K + ++ +E + ++ + I+ +Q
Sbjct: 1097 HKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1156
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKE-SNSQIKFLREEVEKKRVLCEM 611
+ + +EL +++E +D+E L++E + +++ + E+E+ + E+
Sbjct: 1157 SSFTSSEQELERLRSE-NKDIENLRREREHLEMELEKAEMERSTYVTEV 1204
Score = 65.7 bits (153), Expect = 5e-10
Identities = 101/543 (18%), Positives = 237/543 (43%), Gaps = 57/543 (10%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELA---TKFRQSHNNIDFNEIDRKL 164
V + Q ++ + E + EIA L++ IL++ T +S + + N++ +
Sbjct: 396 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 455
Query: 165 SKL--RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
++L + + VQ +AE+ + + + ++ E E++ E + + + + E
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQL---KVQLQEAERRWEEVQSYIRKRTAEHE 512
Query: 223 S----LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK 278
+ L+ +++ + L KLT ++ + +QRL + + ES++ + +
Sbjct: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 279 IEL---EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
L EALK ++ + I ++ ++ + + + K++ +K+ ++L +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSA---SVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Query: 336 LIIKEQE----------MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
L KE+E +KA++++++ A+E+ + E+ QS+ + +
Sbjct: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAH-ELEKMQQSVYVKDDKIRLLEEQ 688
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNC------KDELSTEKFNFIEEIKTLK--D 437
L+ EI + N+QN LK E+ L+ KD + + E+ + LK +
Sbjct: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 438 ELIE----KTINYENEKNKL---NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
EL+E + E E N + N ++ K +++ + +V L + E D
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 491 EL----EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK----A 542
++ E LE ++ + + ++ ++ +T+ L N ++ +E + +L+ K A
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 868
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
K + E N +L +Q V + +E + E++E++ KE +++K L +
Sbjct: 869 NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ--FEELEIVLKEKENELKRLEAML 926
Query: 603 EKK 605
+++
Sbjct: 927 KER 929
Score = 58.8 bits (136), Expect = 6e-08
Identities = 110/527 (20%), Positives = 230/527 (43%), Gaps = 46/527 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
+L++++ + ++ + +E + AQ+Q+ ++A + S + +++ +
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAE 611
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
K +I T + T E+ I +M + +K +AL NE EL
Sbjct: 612 KDK-QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
+++ + V+D + L+E+L E ++E K + + N+++ K E++
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQH------EISNKMEEFK----ILNDQNKAL----KSEVQK 716
Query: 284 LKTKLDEE--KQAI--ISKC-KVDQENLKTKHNASIESLKNQMLK-EKCEALEQLHSQLI 337
L+T + E+ K + + KC + E LKT L K E+ A+ +S L
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 338 IKEQEMKAKL-EQIE-ESASEKLKICEIQFEERSQSIQE-------HCSQQEKTIQY-LE 387
+ Q++KAK +Q+ S E+LK + + + +S++E + +EKT+Q +
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSIT 836
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF--NFIEEIKTLKDELIE---- 441
+++EL+ L Q + +K L + KD +T K+ + EE ++LK + E
Sbjct: 837 SKVQELQNLLKGKEEQMNTMKAVLEEKE--KDLANTGKWLQDLQEENESLKAHVQEVAQH 894
Query: 442 --KTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
K + ++ +L + +++ E + E L + T L++ E + + Q+
Sbjct: 895 NLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI 954
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL---TKEHTRIMEHN 555
+ L + ++ L + E ++ L N L S K A+ K++ + E N
Sbjct: 955 EQLKQQNYQQASSFPPHEELL-KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKN 1013
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+E+L + EK ++ E + VE ++ E+ +K L +V
Sbjct: 1014 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKV 1060
Score = 58.4 bits (135), Expect = 8e-08
Identities = 103/527 (19%), Positives = 228/527 (43%), Gaps = 33/527 (6%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTI-CEYNKQIEDYKNEIAQLQEILKELAT 146
+KK + KI +EL++A+ +++ NK++T+ ++++ +N + +E + +
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKA 858
Query: 147 KFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK 206
+ D + L L+ N + V + ++ S+ S+ ELE
Sbjct: 859 VLEEKEK--DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS-----ASQFEELEIV 911
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA 266
+ +NE+ + L E ++ + L +D+Q++ N+L ++ +Q L+ A +
Sbjct: 912 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE---NKLFKSQIEQ-LKQQNYQQASS 967
Query: 267 LEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN--QM 321
+E + + E + E+ L +LD K A+ + K + + L+ K+ ++E+L + +M
Sbjct: 968 FPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND-LREKNWEAMEALASTEKM 1026
Query: 322 LKEKC-EALEQLHSQLIIKEQEMKAKLEQI--EESASEKLKICE--IQFEERSQSIQEHC 376
L++K + ++ Q+ E E K L+++ + S L E FE++++
Sbjct: 1027 LQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1086
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
S E+ ++ LE ++KE L + K L + +L + K
Sbjct: 1087 SGSEE-VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1145
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
DE KTI + + ++ +NK +L R+ H L + L +++ E
Sbjct: 1146 DE-SHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE--H-LEMELEKAEMERSTYV 1201
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+V+ L + +L T +N + + +++L +++SK T ++E N
Sbjct: 1202 TEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIE-NS 1259
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ ++ EKE + N+ + ++ L + N Q+ +E +
Sbjct: 1260 DVSPETESSEKET---MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 317 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 366
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + +I + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 367 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 427 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 482
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 483 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 536
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 537 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 593 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 627
Score = 32.7 bits (71), Expect = 4.7
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 326
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 327 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE 386
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 387 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 548
>BC112337-1|AAI12338.1| 1306|Homo sapiens kinectin 1 (kinesin
receptor) protein.
Length = 1306
Score = 70.5 bits (165), Expect = 2e-11
Identities = 111/529 (20%), Positives = 236/529 (44%), Gaps = 45/529 (8%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR--- 168
EI NK + N Q + K+E+ +LQ ++ E K E D KL +
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
Query: 169 ----INNTNCHTEHNAVQGTDAEKVSAMINDMRSRI---IELEKKCEALDNEVYDKQMEL 221
I E NA++ T+ ++ + D++++ + E L +++K ++
Sbjct: 752 ETGLIQVATKEEELNAIR-TENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI 810
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S+EE++ L K ++ T ++ Q+ ++KG + +++ E + +L
Sbjct: 811 KSVEELLEAE--LLKVANKEKTVQLSITSKVQELQNLLKGKEE-QMNTMKAVLEEKEKDL 867
Query: 282 EALKT---KLDEEKQAIISKCK-VDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLI 337
L EE +++ + + V Q NLK +AS +LKEK L++L + L
Sbjct: 868 ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 927
Query: 338 IKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSIQEHCS--QQEKTIQYLEQEIKELK 394
+E ++ +K + +++ E K+ + Q E+ + Q+ Q+ S E+ ++ + + KE+
Sbjct: 928 ERESDLSSKTQLLQDVQDEN-KLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS 986
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN 454
L N +S LK + + + ++L + + +E + + + L +K E+ +
Sbjct: 987 ---GLWNELDS-LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1042
Query: 455 LAVEKAIKE-KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE---VLE 510
AVE KE K +SV ++ + L E+ + TS E VLE
Sbjct: 1043 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLH------GFEKKAKECMAGTSGSEEVKVLE 1096
Query: 511 NELTTYKNTLNNTVRECDEYKEALVN----ILKSKAALTKEHTR---IMEHNVTLIESLQ 563
++L EC++YK L + K + ++ +E + ++ + I+ +Q
Sbjct: 1097 HKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1156
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKE-SNSQIKFLREEVEKKRVLCEM 611
+ + +EL +++E +D+E L++E + +++ + E+E+ + E+
Sbjct: 1157 SSFTSSEQELERLRSE-NKDIENLRREREHLEMELEKAEMERSTYVTEV 1204
Score = 65.7 bits (153), Expect = 5e-10
Identities = 101/543 (18%), Positives = 237/543 (43%), Gaps = 57/543 (10%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELA---TKFRQSHNNIDFNEIDRKL 164
V + Q ++ + E + EIA L++ IL++ T +S + + N++ +
Sbjct: 396 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 455
Query: 165 SKL--RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
++L + + VQ +AE+ + + + ++ E E++ E + + + + E
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQL---KVQLQEAERRWEEVQSYIRKRTAEHE 512
Query: 223 S----LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK 278
+ L+ +++ + L KLT ++ + +QRL + + ES++ + +
Sbjct: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 279 IEL---EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
L EALK ++ + I ++ ++ + + + K++ +K+ ++L +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSA---SVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Query: 336 LIIKEQE----------MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY 385
L KE+E +KA++++++ A+E+ + E+ QS+ + +
Sbjct: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAH-ELEKMQQSVYVKDDKIRLLEEQ 688
Query: 386 LEQEIKELKYTLDLTNNQNSDLKQELNNLKNC------KDELSTEKFNFIEEIKTLK--D 437
L+ EI + N+QN LK E+ L+ KD + + E+ + LK +
Sbjct: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 438 ELIE----KTINYENEKNKL---NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDS 490
EL+E + E E N + N ++ K +++ + +V L + E D
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 491 EL----EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSK----A 542
++ E LE ++ + + ++ ++ +T+ L N ++ +E + +L+ K A
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 868
Query: 543 ALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
K + E N +L +Q V + +E + E++E++ KE +++K L +
Sbjct: 869 NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ--FEELEIVLKEKENELKRLEAML 926
Query: 603 EKK 605
+++
Sbjct: 927 KER 929
Score = 58.8 bits (136), Expect = 6e-08
Identities = 110/527 (20%), Positives = 230/527 (43%), Gaps = 46/527 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
+L++++ + ++ + +E + AQ+Q+ ++A + S + +++ +
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAE 611
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
K +I T + T E+ I +M + +K +AL NE EL
Sbjct: 612 KDK-QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
+++ + V+D + L+E+L E ++E K + + N+++ K E++
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQH------EISNKMEEFK----ILNDQNKAL----KSEVQK 716
Query: 284 LKTKLDEE--KQAI--ISKC-KVDQENLKTKHNASIESLKNQMLK-EKCEALEQLHSQLI 337
L+T + E+ K + + KC + E LKT L K E+ A+ +S L
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 338 IKEQEMKAKL-EQIE-ESASEKLKICEIQFEERSQSIQE-------HCSQQEKTIQY-LE 387
+ Q++KAK +Q+ S E+LK + + + +S++E + +EKT+Q +
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSIT 836
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKF--NFIEEIKTLKDELIE---- 441
+++EL+ L Q + +K L + KD +T K+ + EE ++LK + E
Sbjct: 837 SKVQELQNLLKGKEEQMNTMKAVLEEKE--KDLANTGKWLQDLQEENESLKAHVQEVAQH 894
Query: 442 --KTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
K + ++ +L + +++ E + E L + T L++ E + + Q+
Sbjct: 895 NLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI 954
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKS-KAAL---TKEHTRIMEHN 555
+ L + ++ L + E ++ L N L S K A+ K++ + E N
Sbjct: 955 EQLKQQNYQQASSFPPHEELL-KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKN 1013
Query: 556 VTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEV 602
+E+L + EK ++ E + VE ++ E+ +K L +V
Sbjct: 1014 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKV 1060
Score = 58.4 bits (135), Expect = 8e-08
Identities = 103/527 (19%), Positives = 228/527 (43%), Gaps = 33/527 (6%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTI-CEYNKQIEDYKNEIAQLQEILKELAT 146
+KK + KI +EL++A+ +++ NK++T+ ++++ +N + +E + +
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKA 858
Query: 147 KFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK 206
+ D + L L+ N + V + ++ S+ S+ ELE
Sbjct: 859 VLEEKEK--DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS-----ASQFEELEIV 911
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALA 266
+ +NE+ + L E ++ + L +D+Q++ N+L ++ +Q L+ A +
Sbjct: 912 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE---NKLFKSQIEQ-LKQQNYQQASS 967
Query: 267 LEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN--QM 321
+E + + E + E+ L +LD K A+ + K + + L+ K+ ++E+L + +M
Sbjct: 968 FPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND-LREKNWEAMEALASTEKM 1026
Query: 322 LKEKC-EALEQLHSQLIIKEQEMKAKLEQI--EESASEKLKICE--IQFEERSQSIQEHC 376
L++K + ++ Q+ E E K L+++ + S L E FE++++
Sbjct: 1027 LQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1086
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
S E+ ++ LE ++KE L + K L + +L + K
Sbjct: 1087 SGSEE-VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1145
Query: 437 DELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
DE KTI + + ++ +NK +L R+ H L + L +++ E
Sbjct: 1146 DE-SHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE--H-LEMELEKAEMERSTYV 1201
Query: 497 DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNV 556
+V+ L + +L T +N + + +++L +++SK T ++E N
Sbjct: 1202 TEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIE-NS 1259
Query: 557 TLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ ++ EKE + N+ + ++ L + N Q+ +E +
Sbjct: 1260 DVSPETESSEKET---MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 317 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 366
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + +I + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 367 ERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 426
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 427 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 482
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 483 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 536
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 537 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 593 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 627
Score = 32.7 bits (71), Expect = 4.7
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 326
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 327 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE 386
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 387 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 548
>AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protein
130d protein.
Length = 1135
Score = 70.5 bits (165), Expect = 2e-11
Identities = 110/524 (20%), Positives = 239/524 (45%), Gaps = 49/524 (9%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRIN 170
+E+ + + EY ++ +++ + Q E LK+L + +S + E +++++ L+
Sbjct: 173 LELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKE-QEKEKRVTTLKEE 231
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-------EKKCEALDNEVYDKQMELSS 223
T + V + ++++A + R +I EL K + V +++ + +
Sbjct: 232 LTKLKSFALMVVD-EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
Query: 224 LE-EVITVRDSLCKD---LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
LE E+ T +D + KLT+ + + QQ+L + E N S+R+ +
Sbjct: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE- 349
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK--EKCEALEQLHSQLI 337
EL+ +K K+ + + + E L+ K +E +++K E+C L + +
Sbjct: 350 ELQDIKEKISKGEYGNAG-IMAEVEELR-KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 338 IKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE------ 389
++ ++ K ++E++ + A EKL+ + ++ S++ + ++ T + L QE
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 390 -IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
IKEL+ LK++L LK E+ E++K +D+L + +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E+NK+ EK I+E + S + + ++ +T E + L+++++ A+E
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-------KERDDLKNKLK----AEEE 576
Query: 509 LENELTTYKNTLNNTVRECDEY-KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE- 566
N+L + N L N ++ + K+ L N L + K T + + N + E Q VE
Sbjct: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG--KSTTALHQENNKIKELSQEVER 634
Query: 567 -KEAYRELGTIKNELI---EDVELLKK---ESNSQIKFLREEVE 603
K +++ I+++L+ ++ E L++ + +FL +E+E
Sbjct: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
>AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 70.5 bits (165), Expect = 2e-11
Identities = 99/441 (22%), Positives = 209/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K SH+ ++ + ++++
Sbjct: 1137 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVECSHSAKLEQDILEKES 1192
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 1193 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1252
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 1253 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 1311
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 1312 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1366
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 1367 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 1414
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 1415 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 1473
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 1474 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 1528
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 1529 LEIQLKALISSNVQKDNEIEQ 1549
Score = 67.3 bits (157), Expect = 2e-10
Identities = 110/513 (21%), Positives = 243/513 (47%), Gaps = 47/513 (9%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRI 169
E++N+ + E NKQI ++ E++ ++ L+ + +Q +N D E+ + SK +
Sbjct: 897 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 956
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI- 228
N ++ T ++ ++ ++ +++ + LD+ ++L +L ++
Sbjct: 957 QEEKIMKLSNEIE-TATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSN 1014
Query: 229 -TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-ESIRREYK--IELEAL 284
+ D+L + Q L N+ +++ + + + + + ++ E+I E K ++ +
Sbjct: 1015 GSEEDNL-PNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1073
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQ--MLKEKCEALEQLHSQLIIKEQ 341
K+ EE + I K + + + K ++N E KNQ +LKEK ++QL +L K
Sbjct: 1074 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 1133
Query: 342 EMKAKLEQIEE---SASE--------KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ +++ + E + SE K KI E++ +Q ++ CS K LEQ+I
Sbjct: 1134 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVE--CSHSAK----LEQDI 1187
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
E K ++ L +N LK+ +L +D + K ++E+K LK+E+ + T N ++ K
Sbjct: 1188 LE-KESIILKLERN--LKEFQEHL---QDSVKNTKDLNVKELK-LKEEITQLTNNLQDMK 1240
Query: 451 NKLNLAVEKA---IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ L L E+ +E K + LS + L L+ + + L++++ +
Sbjct: 1241 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1300
Query: 508 VLENELTTYKN---TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
++ E++ ++ L + E ++ K L K T + + +N + E++Q
Sbjct: 1301 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR-TIQQLKEQLNNQKVEEAIQQ 1359
Query: 565 VEKEAYRELGTIKNELIEDVEL-LKKESNSQIK 596
E+ A ++L +K ++IED+ + L+++ +Q++
Sbjct: 1360 YER-ACKDL-NVKEKIIEDMRMTLEEQEQTQVE 1390
Score = 44.8 bits (101), Expect = 0.001
Identities = 85/436 (19%), Positives = 176/436 (40%), Gaps = 29/436 (6%)
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A + + +I+ +++ + +NE EL + + I ++ K+L + E
Sbjct: 719 QIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKED 778
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
T+ E Q +K H + N+ I L E SK K+ E +
Sbjct: 779 TINEFQN----LKSHMENTFKCNDKADTSSLIINNKLICNETVEVPK-DSKSKICSERKR 833
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE-----ESASEKLKICE 362
N + K+ + ++ K +E++ + +IE + +E L+
Sbjct: 834 VNENELQQD--EPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFL 891
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD--- 419
+ E ++ +E ++ K I + +QE L L+ +N L +E+ +++ D
Sbjct: 892 LTIENELKNEKEEKAELNKQIVHFQQE-------LSLSEKKNLTLSKEVQQIQSNYDIAI 944
Query: 420 -ELSTEKFNFIEE---IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
EL +K E+ I L +E+ T + N +++ L K I E ++ ++
Sbjct: 945 AELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK-IDELRTLDSVSQISN 1003
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+ +L LR + SE + L + L ++ ++ Y+ N EA+
Sbjct: 1004 --IDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIW 1061
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
K + + + +E IE LQ K E +K + ++ + L KE + I
Sbjct: 1062 EECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLI 1121
Query: 596 KFLREEVEKKRVLCEM 611
+ L+EE+++K V ++
Sbjct: 1122 QQLKEELQEKNVTLDV 1137
Score = 37.5 bits (83), Expect = 0.17
Identities = 66/339 (19%), Positives = 147/339 (43%), Gaps = 22/339 (6%)
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENL----KTKHNASIESLKNQMLKEKCEALEQL 332
Y L LK +K + QE L K+ + S++S N + A
Sbjct: 463 YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISW 522
Query: 333 HSQL--IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ L +++++++ +LE EE+ + + K+ + E+ ++++E+ K E++
Sbjct: 523 ENSLEDLMEDEDLVEELENAEETQNVETKLLD---EDLDKTLEEN-----KAFISHEEKR 574
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF-IEEIKTLKDELI-EKTINYEN 448
K L DL ++ K++L ++E++ E + + K+ L+ E+ I EN
Sbjct: 575 KLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEEN 634
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLRESDSELEQLEDQVQMLTSAKE 507
+ +L + + K + E + + V T + ++ L+D V + E
Sbjct: 635 AERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAE 694
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL--TKEHTRIMEH-NVTLIESLQN 564
+ + + + T ++ + + K+K L TKE + E+ + +LI+ L+
Sbjct: 695 IAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELET 754
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
K+ + IK ELI ++ K+++ ++ + L+ +E
Sbjct: 755 SNKKIITQNQRIK-ELINIID-QKEDTINEFQNLKSHME 791
>AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 70.5 bits (165), Expect = 2e-11
Identities = 99/441 (22%), Positives = 209/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K SH+ ++ + ++++
Sbjct: 1097 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVECSHSAKLEQDILEKES 1152
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 1153 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1212
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 1213 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 1271
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 1272 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1326
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 1327 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 1374
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 1375 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 1433
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 1434 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 1488
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 1489 LEIQLKALISSNVQKDNEIEQ 1509
Score = 67.3 bits (157), Expect = 2e-10
Identities = 110/513 (21%), Positives = 243/513 (47%), Gaps = 47/513 (9%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRI 169
E++N+ + E NKQI ++ E++ ++ L+ + +Q +N D E+ + SK +
Sbjct: 857 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 916
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI- 228
N ++ T ++ ++ ++ +++ + LD+ ++L +L ++
Sbjct: 917 QEEKIMKLSNEIE-TATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSN 974
Query: 229 -TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-ESIRREYK--IELEAL 284
+ D+L + Q L N+ +++ + + + + + ++ E+I E K ++ +
Sbjct: 975 GSEEDNL-PNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1033
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQ--MLKEKCEALEQLHSQLIIKEQ 341
K+ EE + I K + + + K ++N E KNQ +LKEK ++QL +L K
Sbjct: 1034 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 1093
Query: 342 EMKAKLEQIEE---SASE--------KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ +++ + E + SE K KI E++ +Q ++ CS K LEQ+I
Sbjct: 1094 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVE--CSHSAK----LEQDI 1147
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
E K ++ L +N LK+ +L +D + K ++E+K LK+E+ + T N ++ K
Sbjct: 1148 LE-KESIILKLERN--LKEFQEHL---QDSVKNTKDLNVKELK-LKEEITQLTNNLQDMK 1200
Query: 451 NKLNLAVEKA---IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ L L E+ +E K + LS + L L+ + + L++++ +
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1260
Query: 508 VLENELTTYKN---TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
++ E++ ++ L + E ++ K L K T + + +N + E++Q
Sbjct: 1261 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR-TIQQLKEQLNNQKVEEAIQQ 1319
Query: 565 VEKEAYRELGTIKNELIEDVEL-LKKESNSQIK 596
E+ A ++L +K ++IED+ + L+++ +Q++
Sbjct: 1320 YER-ACKDL-NVKEKIIEDMRMTLEEQEQTQVE 1350
Score = 53.6 bits (123), Expect = 2e-06
Identities = 107/531 (20%), Positives = 215/531 (40%), Gaps = 32/531 (6%)
Query: 96 KNKILPQDELVQAQDVEIRNK-DQTICEYNKQIE-DYKNEIAQLQEILKELATKFRQSHN 153
K K++ + + + +IR + Q +Y Q E D+K + Q +EIL+E A +
Sbjct: 584 KKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFK 643
Query: 154 NIDFNEIDRKLSKLRINNTNCHTEH-NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDN 212
++ R+ + I T TE A ++ A + + +I+ +++ + +N
Sbjct: 644 DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKREN 703
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
E EL + + I ++ K+L + E T+ E Q +K H + N+
Sbjct: 704 ESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQN----LKSHMENTFKCNDK 759
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL 332
I L E SK K+ E + N + K+ +
Sbjct: 760 ADTSSLIINNKLICNETVEVPK-DSKSKICSERKRVNENELQQD--EPPAKKGSIHVSSA 816
Query: 333 HSQLIIKEQEMKAKLEQIE-----ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
++ K +E++ + +IE + +E L+ + E ++ +E ++ K I + +
Sbjct: 817 ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQ 876
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKD----ELSTEKFNFIEE---IKTLKDELI 440
QE L L+ +N L +E+ +++ D EL +K E+ I L +E+
Sbjct: 877 QE-------LSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 929
Query: 441 EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
T + N +++ L K I E ++ ++ + +L LR + SE + L +
Sbjct: 930 TATRSITNNVSQIKLMHTK-IDELRTLDSVSQISN--IDLLNLRDLSNGSEEDNLPNTQL 986
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L ++ ++ Y+ N EA+ K + + + +E IE
Sbjct: 987 DLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIE 1046
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
LQ K E +K + ++ + L KE + I+ L+EE+++K V ++
Sbjct: 1047 KLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV 1097
Score = 44.0 bits (99), Expect = 0.002
Identities = 51/210 (24%), Positives = 98/210 (46%), Gaps = 20/210 (9%)
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAI 461
++ DL +EL N + ++ + T+ + E++ KTL++ + I++E ++ L+L +
Sbjct: 531 EDEDLVEELENAEETQN-VETKLLD--EDLDKTLEEN--KAFISHEEKRKLLDLIEDLKK 585
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
K N+ + L++ I +T + ++ E D + L +E+LE
Sbjct: 586 KLINEKKEKLTLEFKIREEVTQEFTQYWAQREA--DFKETLLQEREILEENAERRLAIFK 643
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ V +CD +EA +I +K T+E T +E I++ EL K ELI
Sbjct: 644 DLVGKCDTREEAAKDICATKVE-TEEATACLELKFNQIKA----------ELAKTKGELI 692
Query: 582 EDVELLKKESNSQIKFLRE-EVEKKRVLCE 610
+ E LKK N ++E E K+++ +
Sbjct: 693 KTKEELKKRENESDSLIQELETSNKKIITQ 722
Score = 39.9 bits (89), Expect = 0.031
Identities = 72/350 (20%), Positives = 147/350 (42%), Gaps = 32/350 (9%)
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENL----KTKHNASIESLKNQMLKEKCEALEQL 332
Y L LK +K + QE L K+ + S++S N + A
Sbjct: 463 YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISW 522
Query: 333 HSQL--IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ L +++++++ +LE EE+ + + K+ + E+ ++++E+ K E++
Sbjct: 523 ENSLEDLMEDEDLVEELENAEETQNVETKLLD---EDLDKTLEEN-----KAFISHEEKR 574
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF-IEEIKTLKDELI-EKTINYEN 448
K L DL ++ K++L ++E++ E + + K+ L+ E+ I EN
Sbjct: 575 KLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEEN 634
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSV------TRDIVHVLTLRLRESDSELEQLEDQVQML 502
+ +L + + K + E + + T + L L+ + +EL + + ++
Sbjct: 635 AERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKT 694
Query: 503 TSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
+ ENE L T N + ++ + L+NI+ K E + H +
Sbjct: 695 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSH----M 750
Query: 560 ESLQNVEKEAYRELGTIKNELI--EDVELLKKESNSQIKFLREEVEKKRV 607
E+ +A I N+LI E VE + K+S S+I R+ V + +
Sbjct: 751 ENTFKCNDKADTSSLIINNKLICNETVE-VPKDSKSKICSERKRVNENEL 799
>AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 70.5 bits (165), Expect = 2e-11
Identities = 99/441 (22%), Positives = 209/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K SH+ ++ + ++++
Sbjct: 1097 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVECSHSAKLEQDILEKES 1152
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 1153 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1212
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 1213 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 1271
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 1272 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1326
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 1327 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 1374
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 1375 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 1433
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 1434 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 1488
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 1489 LEIQLKALISSNVQKDNEIEQ 1509
Score = 67.3 bits (157), Expect = 2e-10
Identities = 110/513 (21%), Positives = 243/513 (47%), Gaps = 47/513 (9%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRI 169
E++N+ + E NKQI ++ E++ ++ L+ + +Q +N D E+ + SK +
Sbjct: 857 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 916
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI- 228
N ++ T ++ ++ ++ +++ + LD+ ++L +L ++
Sbjct: 917 QEEKIMKLSNEIE-TATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSN 974
Query: 229 -TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-ESIRREYK--IELEAL 284
+ D+L + Q L N+ +++ + + + + + ++ E+I E K ++ +
Sbjct: 975 GSEEDNL-PNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1033
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQ--MLKEKCEALEQLHSQLIIKEQ 341
K+ EE + I K + + + K ++N E KNQ +LKEK ++QL +L K
Sbjct: 1034 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 1093
Query: 342 EMKAKLEQIEE---SASE--------KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ +++ + E + SE K KI E++ +Q ++ CS K LEQ+I
Sbjct: 1094 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVE--CSHSAK----LEQDI 1147
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
E K ++ L +N LK+ +L +D + K ++E+K LK+E+ + T N ++ K
Sbjct: 1148 LE-KESIILKLERN--LKEFQEHL---QDSVKNTKDLNVKELK-LKEEITQLTNNLQDMK 1200
Query: 451 NKLNLAVEKA---IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ L L E+ +E K + LS + L L+ + + L++++ +
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1260
Query: 508 VLENELTTYKN---TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
++ E++ ++ L + E ++ K L K T + + +N + E++Q
Sbjct: 1261 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR-TIQQLKEQLNNQKVEEAIQQ 1319
Query: 565 VEKEAYRELGTIKNELIEDVEL-LKKESNSQIK 596
E+ A ++L +K ++IED+ + L+++ +Q++
Sbjct: 1320 YER-ACKDL-NVKEKIIEDMRMTLEEQEQTQVE 1350
Score = 53.6 bits (123), Expect = 2e-06
Identities = 107/531 (20%), Positives = 215/531 (40%), Gaps = 32/531 (6%)
Query: 96 KNKILPQDELVQAQDVEIRNK-DQTICEYNKQIE-DYKNEIAQLQEILKELATKFRQSHN 153
K K++ + + + +IR + Q +Y Q E D+K + Q +EIL+E A +
Sbjct: 584 KKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFK 643
Query: 154 NIDFNEIDRKLSKLRINNTNCHTEH-NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDN 212
++ R+ + I T TE A ++ A + + +I+ +++ + +N
Sbjct: 644 DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKREN 703
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
E EL + + I ++ K+L + E T+ E Q +K H + N+
Sbjct: 704 ESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQN----LKSHMENTFKCNDK 759
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL 332
I L E SK K+ E + N + K+ +
Sbjct: 760 ADTSSLIINNKLICNETVEVPK-DSKSKICSERKRVNENELQQD--EPPAKKGSIHVSSA 816
Query: 333 HSQLIIKEQEMKAKLEQIE-----ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
++ K +E++ + +IE + +E L+ + E ++ +E ++ K I + +
Sbjct: 817 ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQ 876
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKD----ELSTEKFNFIEE---IKTLKDELI 440
QE L L+ +N L +E+ +++ D EL +K E+ I L +E+
Sbjct: 877 QE-------LSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 929
Query: 441 EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
T + N +++ L K I E ++ ++ + +L LR + SE + L +
Sbjct: 930 TATRSITNNVSQIKLMHTK-IDELRTLDSVSQISN--IDLLNLRDLSNGSEEDNLPNTQL 986
Query: 501 MLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
L ++ ++ Y+ N EA+ K + + + +E IE
Sbjct: 987 DLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIE 1046
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEM 611
LQ K E +K + ++ + L KE + I+ L+EE+++K V ++
Sbjct: 1047 KLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV 1097
Score = 44.0 bits (99), Expect = 0.002
Identities = 51/210 (24%), Positives = 98/210 (46%), Gaps = 20/210 (9%)
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEI-KTLKDELIEKTINYENEKNKLNLAVEKAI 461
++ DL +EL N + ++ + T+ + E++ KTL++ + I++E ++ L+L +
Sbjct: 531 EDEDLVEELENAEETQN-VETKLLD--EDLDKTLEEN--KAFISHEEKRKLLDLIEDLKK 585
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
K N+ + L++ I +T + ++ E D + L +E+LE
Sbjct: 586 KLINEKKEKLTLEFKIREEVTQEFTQYWAQREA--DFKETLLQEREILEENAERRLAIFK 643
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELI 581
+ V +CD +EA +I +K T+E T +E I++ EL K ELI
Sbjct: 644 DLVGKCDTREEAAKDICATKVE-TEEATACLELKFNQIKA----------ELAKTKGELI 692
Query: 582 EDVELLKKESNSQIKFLRE-EVEKKRVLCE 610
+ E LKK N ++E E K+++ +
Sbjct: 693 KTKEELKKRENESDSLIQELETSNKKIITQ 722
Score = 39.9 bits (89), Expect = 0.031
Identities = 72/350 (20%), Positives = 147/350 (42%), Gaps = 32/350 (9%)
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENL----KTKHNASIESLKNQMLKEKCEALEQL 332
Y L LK +K + QE L K+ + S++S N + A
Sbjct: 463 YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISW 522
Query: 333 HSQL--IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ L +++++++ +LE EE+ + + K+ + E+ ++++E+ K E++
Sbjct: 523 ENSLEDLMEDEDLVEELENAEETQNVETKLLD---EDLDKTLEEN-----KAFISHEEKR 574
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF-IEEIKTLKDELI-EKTINYEN 448
K L DL ++ K++L ++E++ E + + K+ L+ E+ I EN
Sbjct: 575 KLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEEN 634
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSV------TRDIVHVLTLRLRESDSELEQLEDQVQML 502
+ +L + + K + E + + T + L L+ + +EL + + ++
Sbjct: 635 AERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKT 694
Query: 503 TSAKEVLENE---LTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
+ ENE L T N + ++ + L+NI+ K E + H +
Sbjct: 695 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSH----M 750
Query: 560 ESLQNVEKEAYRELGTIKNELI--EDVELLKKESNSQIKFLREEVEKKRV 607
E+ +A I N+LI E VE + K+S S+I R+ V + +
Sbjct: 751 ENTFKCNDKADTSSLIINNKLICNETVE-VPKDSKSKICSERKRVNENEL 799
>AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 70.5 bits (165), Expect = 2e-11
Identities = 99/441 (22%), Positives = 209/441 (47%), Gaps = 48/441 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN-NIDFNEIDRKL 164
VQ Q V + K + + E + + YK +I +L+ IL+ K SH+ ++ + ++++
Sbjct: 1137 VQIQHV-VEGK-RALSELTQGVTCYKAKIKELETILE--TQKVECSHSAKLEQDILEKES 1192
Query: 165 SKLRIN-NTNCHTEH--NAVQGTDAEKVSAM-----INDMRSRIIELEKKCEALDNEVYD 216
L++ N EH ++V+ T V + I + + + +++ + + E
Sbjct: 1193 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1252
Query: 217 KQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRRE 276
+ E L+E ++ + ++L+ L E A+ +++L K ++ S+ R+
Sbjct: 1253 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK-KQIKQVQKEVSVMRD 1311
Query: 277 YKIELEALKTKLDE-EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQ 335
E + L+ K++E EK+ ++C + + + E L NQ ++E + E+
Sbjct: 1312 ---EDKLLRIKINELEKKK--NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD 1366
Query: 336 LIIKE---QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKE 392
L +KE ++M+ LE+ E++ E+ ++ E + EE ++ ++ EK KE
Sbjct: 1367 LNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE----VERLATELEKW--------KE 1414
Query: 393 LKYTLDLTNNQNSDLKQE-----LNNLKNCKDEL--STEKFNFIEEIKTLKDELIEKTIN 445
L+ NNQ S+ + E L L N +DEL S +K+N + K L+++++ T
Sbjct: 1415 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN-ADRKKWLEEKMMLITQA 1473
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
E E N N ++K +++ +F ++ + +LT +L E DS+L++ ++ L +A
Sbjct: 1474 KEAE-NIRNKEMKKYAEDRERFFKQ----QNEMEILTAQLTEKDSDLQKWREERDQLVAA 1528
Query: 506 KEVLENELTTYKNTLNNTVRE 526
E+ L + +N + +
Sbjct: 1529 LEIQLKALISSNVQKDNEIEQ 1549
Score = 67.3 bits (157), Expect = 2e-10
Identities = 110/513 (21%), Positives = 243/513 (47%), Gaps = 47/513 (9%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEIDRKLSKLRI 169
E++N+ + E NKQI ++ E++ ++ L+ + +Q +N D E+ + SK +
Sbjct: 897 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQE 956
Query: 170 NNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVI- 228
N ++ T ++ ++ ++ +++ + LD+ ++L +L ++
Sbjct: 957 QEEKIMKLSNEIE-TATRSITNNVSQIKLMHTKID-ELRTLDSVSQISNIDLLNLRDLSN 1014
Query: 229 -TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN-ESIRREYK--IELEAL 284
+ D+L + Q L N+ +++ + + + + + ++ E+I E K ++ +
Sbjct: 1015 GSEEDNL-PNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSK 1073
Query: 285 KTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQ--MLKEKCEALEQLHSQLIIKEQ 341
K+ EE + I K + + + K ++N E KNQ +LKEK ++QL +L K
Sbjct: 1074 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNV 1133
Query: 342 EMKAKLEQIEE---SASE--------KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ +++ + E + SE K KI E++ +Q ++ CS K LEQ+I
Sbjct: 1134 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVE--CSHSAK----LEQDI 1187
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
E K ++ L +N LK+ +L +D + K ++E+K LK+E+ + T N ++ K
Sbjct: 1188 LE-KESIILKLERN--LKEFQEHL---QDSVKNTKDLNVKELK-LKEEITQLTNNLQDMK 1240
Query: 451 NKLNLAVEKA---IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
+ L L E+ +E K + LS + L L+ + + L++++ +
Sbjct: 1241 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIK 1300
Query: 508 VLENELTTYKN---TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
++ E++ ++ L + E ++ K L K T + + +N + E++Q
Sbjct: 1301 QVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQR-TIQQLKEQLNNQKVEEAIQQ 1359
Query: 565 VEKEAYRELGTIKNELIEDVEL-LKKESNSQIK 596
E+ A ++L +K ++IED+ + L+++ +Q++
Sbjct: 1360 YER-ACKDL-NVKEKIIEDMRMTLEEQEQTQVE 1390
Score = 44.8 bits (101), Expect = 0.001
Identities = 85/436 (19%), Positives = 176/436 (40%), Gaps = 29/436 (6%)
Query: 188 KVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNEL 247
++ A + + +I+ +++ + +NE EL + + I ++ K+L + E
Sbjct: 719 QIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKED 778
Query: 248 TLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLK 307
T+ E Q +K H + N+ I L E SK K+ E +
Sbjct: 779 TINEFQN----LKSHMENTFKCNDKADTSSLIINNKLICNETVEVPK-DSKSKICSERKR 833
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE-----ESASEKLKICE 362
N + K+ + ++ K +E++ + +IE + +E L+
Sbjct: 834 VNENELQQD--EPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFL 891
Query: 363 IQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD--- 419
+ E ++ +E ++ K I + +QE L L+ +N L +E+ +++ D
Sbjct: 892 LTIENELKNEKEEKAELNKQIVHFQQE-------LSLSEKKNLTLSKEVQQIQSNYDIAI 944
Query: 420 -ELSTEKFNFIEE---IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
EL +K E+ I L +E+ T + N +++ L K I E ++ ++
Sbjct: 945 AELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK-IDELRTLDSVSQISN 1003
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+ +L LR + SE + L + L ++ ++ Y+ N EA+
Sbjct: 1004 --IDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIW 1061
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
K + + + +E IE LQ K E +K + ++ + L KE + I
Sbjct: 1062 EECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLI 1121
Query: 596 KFLREEVEKKRVLCEM 611
+ L+EE+++K V ++
Sbjct: 1122 QQLKEELQEKNVTLDV 1137
Score = 37.5 bits (83), Expect = 0.17
Identities = 66/339 (19%), Positives = 147/339 (43%), Gaps = 22/339 (6%)
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENL----KTKHNASIESLKNQMLKEKCEALEQL 332
Y L LK +K + QE L K+ + S++S N + A
Sbjct: 463 YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISW 522
Query: 333 HSQL--IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ L +++++++ +LE EE+ + + K+ + E+ ++++E+ K E++
Sbjct: 523 ENSLEDLMEDEDLVEELENAEETQNVETKLLD---EDLDKTLEEN-----KAFISHEEKR 574
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNF-IEEIKTLKDELI-EKTINYEN 448
K L DL ++ K++L ++E++ E + + K+ L+ E+ I EN
Sbjct: 575 KLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEEN 634
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLRESDSELEQLEDQVQMLTSAKE 507
+ +L + + K + E + + V T + ++ L+D V + E
Sbjct: 635 AERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAE 694
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL--TKEHTRIMEH-NVTLIESLQN 564
+ + + + T ++ + + K+K L TKE + E+ + +LI+ L+
Sbjct: 695 IAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELET 754
Query: 565 VEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
K+ + IK ELI ++ K+++ ++ + L+ +E
Sbjct: 755 SNKKIITQNQRIK-ELINIID-QKEDTINEFQNLKSHME 791
>AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protein
130c protein.
Length = 1133
Score = 70.5 bits (165), Expect = 2e-11
Identities = 110/524 (20%), Positives = 239/524 (45%), Gaps = 49/524 (9%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRIN 170
+E+ + + EY ++ +++ + Q E LK+L + +S + E +++++ L+
Sbjct: 173 LELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKE-QEKEKRVTTLKEE 231
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-------EKKCEALDNEVYDKQMELSS 223
T + V + ++++A + R +I EL K + V +++ + +
Sbjct: 232 LTKLKSFALMVVD-EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
Query: 224 LE-EVITVRDSLCKD---LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
LE E+ T +D + KLT+ + + QQ+L + E N S+R+ +
Sbjct: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE- 349
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK--EKCEALEQLHSQLI 337
EL+ +K K+ + + + E L+ K +E +++K E+C L + +
Sbjct: 350 ELQDIKEKISKGEYGNAG-IMAEVEELR-KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 338 IKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE------ 389
++ ++ K ++E++ + A EKL+ + ++ S++ + ++ T + L QE
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 390 -IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
IKEL+ LK++L LK E+ E++K +D+L + +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E+NK+ EK I+E + S + + ++ +T E + L+++++ A+E
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-------KERDDLKNKLK----AEEE 576
Query: 509 LENELTTYKNTLNNTVRECDEY-KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE- 566
N+L + N L N ++ + K+ L N L + K T + + N + E Q VE
Sbjct: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG--KSTTALHQENNKIKELSQEVER 634
Query: 567 -KEAYRELGTIKNELI---EDVELLKK---ESNSQIKFLREEVE 603
K +++ I+++L+ ++ E L++ + +FL +E+E
Sbjct: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
>AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protein
130b protein.
Length = 1133
Score = 70.5 bits (165), Expect = 2e-11
Identities = 110/524 (20%), Positives = 239/524 (45%), Gaps = 49/524 (9%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRIN 170
+E+ + + EY ++ +++ + Q E LK+L + +S + E +++++ L+
Sbjct: 173 LELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKE-QEKEKRVTTLKEE 231
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-------EKKCEALDNEVYDKQMELSS 223
T + V + ++++A + R +I EL K + V +++ + +
Sbjct: 232 LTKLKSFALMVVD-EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
Query: 224 LE-EVITVRDSLCKD---LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
LE E+ T +D + KLT+ + + QQ+L + E N S+R+ +
Sbjct: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE- 349
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK--EKCEALEQLHSQLI 337
EL+ +K K+ + + + E L+ K +E +++K E+C L + +
Sbjct: 350 ELQDIKEKISKGEYGNAG-IMAEVEELR-KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 338 IKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE------ 389
++ ++ K ++E++ + A EKL+ + ++ S++ + ++ T + L QE
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 390 -IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
IKEL+ LK++L LK E+ E++K +D+L + +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E+NK+ EK I+E + S + + ++ +T E + L+++++ A+E
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-------KERDDLKNKLK----AEEE 576
Query: 509 LENELTTYKNTLNNTVRECDEY-KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE- 566
N+L + N L N ++ + K+ L N L + K T + + N + E Q VE
Sbjct: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG--KSTTALHQENNKIKELSQEVER 634
Query: 567 -KEAYRELGTIKNELI---EDVELLKK---ESNSQIKFLREEVE 603
K +++ I+++L+ ++ E L++ + +FL +E+E
Sbjct: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
>AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protein
130a protein.
Length = 1135
Score = 70.5 bits (165), Expect = 2e-11
Identities = 110/524 (20%), Positives = 239/524 (45%), Gaps = 49/524 (9%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRIN 170
+E+ + + EY ++ +++ + Q E LK+L + +S + E +++++ L+
Sbjct: 173 LELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKE-QEKEKRVTTLKEE 231
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-------EKKCEALDNEVYDKQMELSS 223
T + V + ++++A + R +I EL K + V +++ + +
Sbjct: 232 LTKLKSFALMVVD-EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
Query: 224 LE-EVITVRDSLCKD---LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
LE E+ T +D + KLT+ + + QQ+L + E N S+R+ +
Sbjct: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE- 349
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK--EKCEALEQLHSQLI 337
EL+ +K K+ + + + E L+ K +E +++K E+C L + +
Sbjct: 350 ELQDIKEKISKGEYGNAG-IMAEVEELR-KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 338 IKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE------ 389
++ ++ K ++E++ + A EKL+ + ++ S++ + ++ T + L QE
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 390 -IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
IKEL+ LK++L LK E+ E++K +D+L + +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E+NK+ EK I+E + S + + ++ +T E + L+++++ A+E
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-------KERDDLKNKLK----AEEE 576
Query: 509 LENELTTYKNTLNNTVRECDEY-KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE- 566
N+L + N L N ++ + K+ L N L + K T + + N + E Q VE
Sbjct: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG--KSTTALHQENNKIKELSQEVER 634
Query: 567 -KEAYRELGTIKNELI---EDVELLKK---ESNSQIKFLREEVE 603
K +++ I+++L+ ++ E L++ + +FL +E+E
Sbjct: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
>AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protein
90 protein.
Length = 764
Score = 70.5 bits (165), Expect = 2e-11
Identities = 110/524 (20%), Positives = 239/524 (45%), Gaps = 49/524 (9%)
Query: 111 VEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRIN 170
+E+ + + EY ++ +++ + Q E LK+L + +S + E +++++ L+
Sbjct: 173 LELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKE-QEKEKRVTTLKEE 231
Query: 171 NTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-------EKKCEALDNEVYDKQMELSS 223
T + V + ++++A + R +I EL K + V +++ + +
Sbjct: 232 LTKLKSFALMVVD-EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
Query: 224 LE-EVITVRDSLCKD---LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
LE E+ T +D + KLT+ + + QQ+L + E N S+R+ +
Sbjct: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE- 349
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLK--EKCEALEQLHSQLI 337
EL+ +K K+ + + + E L+ K +E +++K E+C L + +
Sbjct: 350 ELQDIKEKISKGEYGNAG-IMAEVEELR-KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 338 IKEQEMKAKLEQIEES--ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE------ 389
++ ++ K ++E++ + A EKL+ + ++ S++ + ++ T + L QE
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 390 -IKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
IKEL+ LK++L LK E+ E++K +D+L + +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
E+NK+ EK I+E + S + + ++ +T E + L+++++ A+E
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-------KERDDLKNKLK----AEEE 576
Query: 509 LENELTTYKNTLNNTVRECDEY-KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE- 566
N+L + N L N ++ + K+ L N L + K T + + N + E Q VE
Sbjct: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG--KSTTALHQENNKIKELSQEVER 634
Query: 567 -KEAYRELGTIKNELI---EDVELLKK---ESNSQIKFLREEVE 603
K +++ I+++L+ ++ E L++ + +FL +E+E
Sbjct: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
>AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin heavy
chain SM1 protein.
Length = 622
Score = 70.5 bits (165), Expect = 2e-11
Identities = 109/521 (20%), Positives = 233/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 59 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 117
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 118 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 177
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 178 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 237
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 238 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 292
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++ + +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 293 AIKHVR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 350
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 351 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 403
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 404 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 463
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 464 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 519
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 520 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 559
Score = 55.2 bits (127), Expect = 8e-07
Identities = 103/544 (18%), Positives = 215/544 (39%), Gaps = 33/544 (6%)
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL----EEVITVRDSLCKD---LQEK 241
++ ++D + ++ + EAL+ Q E+ +L EE D L K LQ++
Sbjct: 19 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 78
Query: 242 LTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
L + L +Q LE + L ++I +Y E + + + E++ +S
Sbjct: 79 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 138
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+ +E L+ K N+MLK + E L + E++ K ++ E+ E++
Sbjct: 139 ARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEM 194
Query: 359 KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN-LKNC 417
K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L L
Sbjct: 195 KTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEY 251
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
+ EL E+ K +L + E + + E+AIK K + + +
Sbjct: 252 ETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDFQRE 310
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
+ E + ++ E + + L + L+ +L + E +E E L +
Sbjct: 311 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 370
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELIEDVELL 587
L + AL E R+ L E L+ N+E ++A ++ + NEL +
Sbjct: 371 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 430
Query: 588 KKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERY 647
+K +++ + R+ E + L EM +AQ + + E +
Sbjct: 431 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 490
Query: 648 XXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLR 703
+ E+ L R+ E+ K ++ + +LK+ LE+++ + + R
Sbjct: 491 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 550
Query: 704 KSLK 707
+ L+
Sbjct: 551 RKLQ 554
>AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin heavy
chain SM2 protein.
Length = 588
Score = 70.5 bits (165), Expect = 2e-11
Identities = 109/521 (20%), Positives = 233/521 (44%), Gaps = 39/521 (7%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQ---SHNNIDF-- 157
+E A D + K++ E + + D N+ QL L++ KF Q NI
Sbjct: 59 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKY 117
Query: 158 -NEIDRKLSKLRINNTNCHTEHNAVQ-GTDAEKVSAMINDM-RSRIIELEKKCEALDNEV 214
+E DR ++ R T + A++ +A++ N M ++ + +L + + V
Sbjct: 118 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 177
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA----N 270
++ + +LE + + ++L+++L + E + ++ +KG L+A N
Sbjct: 178 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 237
Query: 271 ESIRREYKIELEALKTKLDEEKQ--AIISKCKVDQE-NLKTKHNASIESLKNQMLKEKCE 327
E RR+ + +L +T+L++E++ A+ + K E +LK +E + +K + E
Sbjct: 238 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----DLELQADSAIKGREE 292
Query: 328 ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
A++ + +L + ++ + +LE S E + + E++++S++ Q ++ + E
Sbjct: 293 AIKHVR-KLQAQMKDFQRELEDARASRDEIFATAK-ENEKKAKSLEADLMQLQEDLAAAE 350
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
+ K+ DL + +L +EL + + ++ L EK I L++EL E+ N E
Sbjct: 351 RARKQA----DL---EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 403
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTR---DIVHVLTLRLRESDSELEQLEDQVQ-MLT 503
+++ A ++A + N+ T S + L + +E S+L ++E V+
Sbjct: 404 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK 463
Query: 504 SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ 563
S LE ++ + + RE K+A LK K KE +E + E +
Sbjct: 464 STIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 519
Query: 564 NVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
++ + +K +L E+ E + N+ + L+ E+++
Sbjct: 520 EQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDE 559
Score = 55.2 bits (127), Expect = 8e-07
Identities = 103/544 (18%), Positives = 215/544 (39%), Gaps = 33/544 (6%)
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL----EEVITVRDSLCKD---LQEK 241
++ ++D + ++ + EAL+ Q E+ +L EE D L K LQ++
Sbjct: 19 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 78
Query: 242 LTSNELTLAETQQ---RLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
L + L +Q LE + L ++I +Y E + + + E++ +S
Sbjct: 79 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 138
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+ +E L+ K N+MLK + E L + E++ K ++ E+ E++
Sbjct: 139 ARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEM 194
Query: 359 KICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNN-LKNC 417
K + E+ Q+ ++ + E +Q L+ + + L + QN + +++L L
Sbjct: 195 KTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEY 251
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
+ EL E+ K +L + E + + E+AIK K + + +
Sbjct: 252 ETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDFQRE 310
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNI 537
+ E + ++ E + + L + L+ +L + E +E E L +
Sbjct: 311 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 370
Query: 538 LKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKNELIEDVELL 587
L + AL E R+ L E L+ N+E ++A ++ + NEL +
Sbjct: 371 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 430
Query: 588 KKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERY 647
+K +++ + R+ E + L EM +AQ + + E +
Sbjct: 431 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 490
Query: 648 XXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLR 703
+ E+ L R+ E+ K ++ + +LK+ LE+++ + + R
Sbjct: 491 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 550
Query: 704 KSLK 707
+ L+
Sbjct: 551 RKLQ 554
>M63618-1|AAA35606.1| 2095|Homo sapiens bullous pemphigoid antigen
protein.
Length = 2095
Score = 70.1 bits (164), Expect = 3e-11
Identities = 113/515 (21%), Positives = 225/515 (43%), Gaps = 57/515 (11%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q E K + +L++ + EL R++ D E+ +L+ L++ T+ + ++
Sbjct: 799 QQEHDKQKAEELKQQVDELTAANRKAEQ--DMRELTYELNALQLEKTSSEEKARLLK--- 853
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQM-ELS--------SLEEVITVRDSLCK 236
+K+ N +R +ELE+K +A + Y +Q+ EL EE + L K
Sbjct: 854 -DKLDETNNTLRCLKLELERKDQA--EKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKK 910
Query: 237 ---DLQEKLTSNELTLAETQQRLEMVKGHHALALEAN--------ESIRREYKIEL---- 281
+ Q +L S + Q+ ++ + HA+A E N S R E ++E
Sbjct: 911 IKRNYQLELESLNHEKGKLQREVDRITRAHAVA-EKNIQHLNSQIHSFRDEKELERLQIC 969
Query: 282 ----EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN----QMLKEKCEALEQLH 333
+ LK + ++ + ++ K ++EN + E K+ +MLK+K E L + +
Sbjct: 970 QRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQN 1029
Query: 334 SQLIIKEQEMKAKLEQIE------ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
++ + Q ++A+ E I + E LKI F+++ +S EH +Q KT Q +
Sbjct: 1030 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1089
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL---IEKTI 444
++IK L+ L + N S+ KQ+ + E N E+ K+E +K
Sbjct: 1090 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1149
Query: 445 NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
+ + +LN ++K E + +T + + + E+ +++ L
Sbjct: 1150 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME 1209
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
+K + EN+++ + + +E +E K KE R ++ ++ Q+
Sbjct: 1210 SKVITENDISGIRLDFVSLQQENSRAQEN----AKLCETNIKELERQLQQYREQMQQGQH 1265
Query: 565 VEKEAYRELGTIKNELI---EDVELLKKESNSQIK 596
+E Y++ +++ELI +VE LK++ + QIK
Sbjct: 1266 MEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1300
Score = 66.1 bits (154), Expect = 4e-10
Identities = 97/481 (20%), Positives = 203/481 (42%), Gaps = 35/481 (7%)
Query: 184 TDAEKVSAMINDMRSRIIE-LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKL 242
++ E++ A + +SR+ E L K EA +NE+ +Q + + +S K + +L
Sbjct: 587 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 646
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK------QAII 296
+ ++ LE V+ L +EA E+ R + L + +L+E + +
Sbjct: 647 ETIVREKEAAERELERVR---QLTIEA-EAKRAAVEENLLNFRNQLEENTFTRRTLEDHL 702
Query: 297 SKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEESA 354
+ + +L+ + N +E L+ + E+ + ++Q+ L ++Q + +L++ ++
Sbjct: 703 KRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIE 762
Query: 355 SE-KLKICEIQFEERSQSIQEHCSQQE---KTIQYLEQE-----IKELKYTLDLTNNQNS 405
E + KI EIQ+ R ++ Q + + L+QE +ELK +D N
Sbjct: 763 LEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANR 822
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+Q++ L + L EK + E+ + LKD+L E N L L +E+ + +
Sbjct: 823 KAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN----NTLRCLKLELERKDQAEK 878
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ L L +L ++ + E+ + L K + EL + + R
Sbjct: 879 GYSQQL-------RELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQR 931
Query: 526 ECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E D A K+ L + H+ E + ++ Q + +L++++
Sbjct: 932 EVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNI 991
Query: 585 ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN 644
+ +KE+N +I+ L EE+EK EM +++++ + A+ + E
Sbjct: 992 KA-EKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK 1050
Query: 645 E 645
+
Sbjct: 1051 Q 1051
Score = 65.3 bits (152), Expect = 7e-10
Identities = 100/513 (19%), Positives = 226/513 (44%), Gaps = 49/513 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ----LQEILKELATKFRQS 151
K+K+ + ++ +E+ KDQ Y++Q+ + ++ Q +E ++E + +
Sbjct: 853 KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 912
Query: 152 HN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR-SRIIELEKKCEA 209
N ++ ++ + KL+ + T +AV + + +++ I+ R + +E + C+
Sbjct: 913 RNYQLELESLNHEKGKLQ-REVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 971
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALE 268
+ + +Q E S + + ++ K+ +K+ L ++ + EM+K L +
Sbjct: 972 KSDHL-KEQFEKSHEQLLQNIKAE--KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ 1028
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
NE+ +I+ E+ L EKQ I +C E LK + + K+Q+
Sbjct: 1029 NNETKLMMQRIQAESENIVL--EKQTIQQRC----EALKIQ----ADGFKDQLRSTN--- 1075
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
E LH Q EQ+ + K++ +EE ++ + +F+++ C QQ IQ ++
Sbjct: 1076 -EHLHKQ-TKTEQDFQRKIKCLEEDLAKSQNLVS-EFKQK-------CDQQNIIIQNTKK 1125
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE--IKTLKDELI-EKTIN 445
E++ L L+ + + +Q++ + EL+ +E +KT+++++ K +
Sbjct: 1126 EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVL 1185
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
++ E K + E+ K+ K S +T + + + L E + ++ ++ +
Sbjct: 1186 FQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETN 1245
Query: 506 KEVLENELTTYKNTLN-------NTVRECDEYKEALVNILKSKAAL-TKEHTRIMEHNVT 557
+ LE +L Y+ + N ++C + ++ L+ + L K +I EH
Sbjct: 1246 IKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQ 1305
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
L+ ++K++ + T K D E+ KE
Sbjct: 1306 LVLLQCEIQKKSTAKDCTFK----PDFEMTVKE 1334
Score = 55.6 bits (128), Expect = 6e-07
Identities = 91/491 (18%), Positives = 201/491 (40%), Gaps = 39/491 (7%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSK 166
QA + ++ + +CE I D KN I L LK+ ++ + F+ ++ +L K
Sbjct: 302 QAAEALVKLYETKLCEEEAVIAD-KNNIENLISTLKQWRSEVDEKRQV--FHALEDELQK 358
Query: 167 LRINNTNC---HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC---EALDNEVYDKQME 220
+ + + E + EK ++ ++ ++++ + E + + +
Sbjct: 359 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 418
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
L++ I ++ + +QE N TLA + +M+ + + ++ Y +
Sbjct: 419 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK-YAEQ 477
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKE 340
A T D E Q + + VD + ++S + +++E + + + + +
Sbjct: 478 YSA--TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMT 535
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTL 397
Q +K + ++ E++K C+ E + S + +Q+ T+ L +I EL+ +
Sbjct: 536 QYIKFAGDSLKRLEEEEIKRCKETSEHGAYS--DLLQRQKATVLENSKLTGKISELERMV 593
Query: 398 DLTNNQNSDLKQELNNLKNC-KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
Q S +++EL ++ ++EL ++ N +E+I K I E+E +
Sbjct: 594 AELKKQKSRVEEELPKVREAAENELRKQQRN-VEDISLQK-------IRAESEAKQYRRE 645
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE------ 510
+E ++EK E L R + + + L +Q++ T + LE
Sbjct: 646 LETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRK 705
Query: 511 ----NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
N+L KN L +R + +E L+ ++K ++ E ++ Q +E
Sbjct: 706 DLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ---LKEKQKIE 762
Query: 567 KEAYRELGTIK 577
EA R++ I+
Sbjct: 763 LEARRKITEIQ 773
>M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain
beta-subunit protein.
Length = 611
Score = 70.1 bits (164), Expect = 3e-11
Identities = 94/479 (19%), Positives = 212/479 (44%), Gaps = 46/479 (9%)
Query: 159 EIDRKLSKLRINNTNCHTEH--NAVQGTDA-----EKVSAMINDMRSRIIELEKKCEALD 211
E+ R LSK T++ +A+Q T+ +K++ + + + + KC +L+
Sbjct: 32 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 91
Query: 212 NEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE 271
+ Q E+ L + ++ L +K + + LAE +Q+ E + LE+++
Sbjct: 92 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE----LESSQ 147
Query: 272 SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQ 331
R EL LK +E + + K + +NL+ + + E L + + LE+
Sbjct: 148 KEARSLSTELFKLKNAYEESLEHL-ETFKRENKNLQEEISDLTEQLGSS--GKTIHELEK 204
Query: 332 LHSQLIIKEQEMKAKLEQIEESASE---KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
+ QL ++ E+++ LE+ E S K+ +++F + I+ +++++ ++ ++
Sbjct: 205 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 264
Query: 389 E----IKELKYTLDL-TNNQNSDL---KQELNNLKNCKDELSTEKFNFIE---EIKTLKD 437
+ L+ +LD T ++N L K+ +L + +LS E ++K+L+
Sbjct: 265 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQS 324
Query: 438 ELIEKTINYE-----NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
L + I + N+ K N+A+ + + N + L R +V + +D EL
Sbjct: 325 LLKDTQIQLDDAVRANDDLKENIAIVE--RRNNLLQAELEELRAVVEQTERSRKLADREL 382
Query: 493 EQLEDQVQMLTSA-------KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALT 545
+ ++VQ+L S K+ ++ +L+ + + V+EC +E + A +
Sbjct: 383 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA 442
Query: 546 KEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+E + + + L+ ++K + + +++ L E ++ K Q++ L V +
Sbjct: 443 EELKKEQDTSA----HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 497
Score = 67.7 bits (158), Expect = 1e-10
Identities = 96/451 (21%), Positives = 191/451 (42%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + +TI E K + + E +L
Sbjct: 158 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKMEL 216
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 217 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 276
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ + ++KK E NE+ +++LS + K LQ L ++
Sbjct: 277 LDAETRS-RNEALRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 332
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ D+E ++T
Sbjct: 333 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLADRELIET 385
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + ++ SQL + +E + EE A + + + EE
Sbjct: 386 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 445
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + ++EL
Sbjct: 446 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 504
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E+++ NL +D+V L
Sbjct: 505 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR----------------LQDLVDKLQ 548
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 549 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 579
Score = 54.4 bits (125), Expect = 1e-06
Identities = 70/367 (19%), Positives = 161/367 (43%), Gaps = 19/367 (5%)
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E + + E++EE A +KL + EE +++ CS EKT L+ EI++L ++
Sbjct: 52 ETDAIQRTEELEE-AKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 110
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
+N + L ++ N D++ E EE ++ + ++ + E KL A E+
Sbjct: 111 SNAAAAALDKKQRNF----DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 166
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNT 519
+++ F+ ++ + LT +L S + +LE + L + K L++ L + +
Sbjct: 167 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 226
Query: 520 LNN----TVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ---NVEKEAYRE 572
L + +R E+ + I + A +E + +++ +++SLQ + E + E
Sbjct: 227 LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 286
Query: 573 LGTIKNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE--MXXXXXXXXXXXXXXSR 627
+K ++ + ++E+ +N +++V+ + L +
Sbjct: 287 ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN 346
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK 687
+ + + +L + E E R + + L+ + +E + + ++ +S+I++ KK
Sbjct: 347 IAIVERRNNLLQAELEELRAVVEQTERSRKLADRELI-ETSERVQLLHSQNTSLINQKKK 405
Query: 688 -DLEQSQ 693
D + SQ
Sbjct: 406 MDADLSQ 412
Score = 54.4 bits (125), Expect = 1e-06
Identities = 64/321 (19%), Positives = 146/321 (45%), Gaps = 24/321 (7%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
D ++ ++ E +K+ ++L + + D Q++L ++ + D L +++
Sbjct: 297 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL---DDAVRANDDLKENIAIVERR 353
Query: 245 NELTLAETQQ-RLEMVKGHHALALEANESIRREYKIEL-EALKTKLDEEKQAIISKCKVD 302
N L AE ++ R + + + L E I +++L + T L +K+ K D
Sbjct: 354 NNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKK----KMDAD 409
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQ-LHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+T+ +++ +N K K + + ++ + KEQ+ A LE+++++ + +K
Sbjct: 410 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 469
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL 421
+ + +E Q + +Q +Q LE ++EL+ L+ +N++ + + + EL
Sbjct: 470 QHRLDEAEQIALKGGKKQ---LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL 526
Query: 422 STEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
+ + + + L+D L++K + K+ +A + + + T+LS R + H
Sbjct: 527 TYQTEEDRKNLLRLQD-LVDKL------QLKVKAYKRQAEEAEEQANTNLSKFRKVQH-- 577
Query: 482 TLRLRESDSELEQLEDQVQML 502
L E++ + E QV L
Sbjct: 578 --ELDEAEERADIAESQVNKL 596
Score = 34.7 bits (76), Expect = 1.2
Identities = 55/291 (18%), Positives = 115/291 (39%), Gaps = 18/291 (6%)
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFET-SLSVTRDIVHV---LTLRLRESDS 490
L+++ E+T + L+ A + + + K+ET ++ T ++ L RL+E++
Sbjct: 19 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 78
Query: 491 ELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
+E + + L K L+NE+ L V + AL ++ + E +
Sbjct: 79 AVEAVNAKCSSLEKTKHRLQNEI----EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 134
Query: 551 IMEHNVTLIESLQNVEKEAYRELGTIKN---ELIEDVELLKKESNS---QIKFLREEVEK 604
E + + +ES Q + EL +KN E +E +E K+E+ + +I L E++
Sbjct: 135 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 194
Query: 605 KRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELS-L 663
+ L +A A LE+E + + E+
Sbjct: 195 SGKTIHELEKVRKQLEAEKMELQSALEEAEAS---LEHEEGKILRAQLEFNQIKAEIERK 251
Query: 664 LRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQ 714
L +++EE+ ++D L+ L+ + ++K ++ M+
Sbjct: 252 LAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 302
>L11690-1|AAA52288.1| 2649|Homo sapiens bullous pemphigoid antigen
protein.
Length = 2649
Score = 70.1 bits (164), Expect = 3e-11
Identities = 113/515 (21%), Positives = 225/515 (43%), Gaps = 57/515 (11%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q E K + +L++ + EL R++ D E+ +L+ L++ T+ + ++
Sbjct: 1353 QQEHDKQKAEELKQQVDELTAANRKAEQ--DMRELTYELNALQLEKTSSEEKARLLK--- 1407
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQM-ELS--------SLEEVITVRDSLCK 236
+K+ N +R +ELE+K +A + Y +Q+ EL EE + L K
Sbjct: 1408 -DKLDETNNTLRCLKLELERKDQA--EKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKK 1464
Query: 237 ---DLQEKLTSNELTLAETQQRLEMVKGHHALALEAN--------ESIRREYKIEL---- 281
+ Q +L S + Q+ ++ + HA+A E N S R E ++E
Sbjct: 1465 IKRNYQLELESLNHEKGKLQREVDRITRAHAVA-EKNIQHLNSQIHSFRDEKELERLQIC 1523
Query: 282 ----EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN----QMLKEKCEALEQLH 333
+ LK + ++ + ++ K ++EN + E K+ +MLK+K E L + +
Sbjct: 1524 QRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQN 1583
Query: 334 SQLIIKEQEMKAKLEQIE------ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
++ + Q ++A+ E I + E LKI F+++ +S EH +Q KT Q +
Sbjct: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL---IEKTI 444
++IK L+ L + N S+ KQ+ + E N E+ K+E +K
Sbjct: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703
Query: 445 NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
+ + +LN ++K E + +T + + + E+ +++ L
Sbjct: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME 1763
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
+K + EN+++ + + +E +E K KE R ++ ++ Q+
Sbjct: 1764 SKVITENDISGIRLDFVSLQQENSRAQEN----AKLCETNIKELERQLQQYREQMQQGQH 1819
Query: 565 VEKEAYRELGTIKNELI---EDVELLKKESNSQIK 596
+E Y++ +++ELI +VE LK++ + QIK
Sbjct: 1820 MEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
Score = 66.1 bits (154), Expect = 4e-10
Identities = 97/481 (20%), Positives = 203/481 (42%), Gaps = 35/481 (7%)
Query: 184 TDAEKVSAMINDMRSRIIE-LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKL 242
++ E++ A + +SR+ E L K EA +NE+ +Q + + +S K + +L
Sbjct: 1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK------QAII 296
+ ++ LE V+ L +EA E+ R + L + +L+E + +
Sbjct: 1201 ETIVREKEAAERELERVR---QLTIEA-EAKRAAVEENLLNFRNQLEENTFTRRTLEDHL 1256
Query: 297 SKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEESA 354
+ + +L+ + N +E L+ + E+ + ++Q+ L ++Q + +L++ ++
Sbjct: 1257 KRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIE 1316
Query: 355 SE-KLKICEIQFEERSQSIQEHCSQQE---KTIQYLEQE-----IKELKYTLDLTNNQNS 405
E + KI EIQ+ R ++ Q + + L+QE +ELK +D N
Sbjct: 1317 LEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANR 1376
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+Q++ L + L EK + E+ + LKD+L E N L L +E+ + +
Sbjct: 1377 KAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN----NTLRCLKLELERKDQAEK 1432
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ L L +L ++ + E+ + L K + EL + + R
Sbjct: 1433 GYSQQL-------RELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQR 1485
Query: 526 ECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E D A K+ L + H+ E + ++ Q + +L++++
Sbjct: 1486 EVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNI 1545
Query: 585 ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN 644
+ +KE+N +I+ L EE+EK EM +++++ + A+ + E
Sbjct: 1546 KA-EKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK 1604
Query: 645 E 645
+
Sbjct: 1605 Q 1605
Score = 65.3 bits (152), Expect = 7e-10
Identities = 100/513 (19%), Positives = 226/513 (44%), Gaps = 49/513 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ----LQEILKELATKFRQS 151
K+K+ + ++ +E+ KDQ Y++Q+ + ++ Q +E ++E + +
Sbjct: 1407 KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 1466
Query: 152 HN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR-SRIIELEKKCEA 209
N ++ ++ + KL+ + T +AV + + +++ I+ R + +E + C+
Sbjct: 1467 RNYQLELESLNHEKGKLQ-REVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALE 268
+ + +Q E S + + ++ K+ +K+ L ++ + EM+K L +
Sbjct: 1526 KSDHL-KEQFEKSHEQLLQNIKAE--KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ 1582
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
NE+ +I+ E+ L EKQ I +C E LK + + K+Q+
Sbjct: 1583 NNETKLMMQRIQAESENIVL--EKQTIQQRC----EALKIQ----ADGFKDQLRSTN--- 1629
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
E LH Q EQ+ + K++ +EE ++ + +F+++ C QQ IQ ++
Sbjct: 1630 -EHLHKQ-TKTEQDFQRKIKCLEEDLAKSQNLVS-EFKQK-------CDQQNIIIQNTKK 1679
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE--IKTLKDELI-EKTIN 445
E++ L L+ + + +Q++ + EL+ +E +KT+++++ K +
Sbjct: 1680 EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVL 1739
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
++ E K + E+ K+ K S +T + + + L E + ++ ++ +
Sbjct: 1740 FQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETN 1799
Query: 506 KEVLENELTTYKNTLN-------NTVRECDEYKEALVNILKSKAAL-TKEHTRIMEHNVT 557
+ LE +L Y+ + N ++C + ++ L+ + L K +I EH
Sbjct: 1800 IKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQ 1859
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
L+ ++K++ + T K D E+ KE
Sbjct: 1860 LVLLQCEIQKKSTAKDCTFK----PDFEMTVKE 1888
Score = 55.6 bits (128), Expect = 6e-07
Identities = 91/491 (18%), Positives = 201/491 (40%), Gaps = 39/491 (7%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSK 166
QA + ++ + +CE I D KN I L LK+ ++ + F+ ++ +L K
Sbjct: 856 QAAEALVKLYETKLCEEEAVIAD-KNNIENLISTLKQWRSEVDEKRQV--FHALEDELQK 912
Query: 167 LRINNTNC---HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC---EALDNEVYDKQME 220
+ + + E + EK ++ ++ ++++ + E + + +
Sbjct: 913 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
L++ I ++ + +QE N TLA + +M+ + + ++ Y +
Sbjct: 973 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK-YAEQ 1031
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKE 340
A T D E Q + + VD + ++S + +++E + + + + +
Sbjct: 1032 YSA--TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMT 1089
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTL 397
Q +K + ++ E++K C+ E + S + +Q+ T+ L +I EL+ +
Sbjct: 1090 QYIKFAGDSLKRLEEEEIKRCKETSEHGAYS--DLLQRQKATVLENSKLTGKISELERMV 1147
Query: 398 DLTNNQNSDLKQELNNLKNC-KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
Q S +++EL ++ ++EL ++ N +E+I K I E+E +
Sbjct: 1148 AELKKQKSRVEEELPKVREAAENELRKQQRN-VEDISLQK-------IRAESEAKQYRRE 1199
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE------ 510
+E ++EK E L R + + + L +Q++ T + LE
Sbjct: 1200 LETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRK 1259
Query: 511 ----NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
N+L KN L +R + +E L+ ++K ++ E ++ Q +E
Sbjct: 1260 DLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ---LKEKQKIE 1316
Query: 567 KEAYRELGTIK 577
EA R++ I+
Sbjct: 1317 LEARRKITEIQ 1327
>BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting
protein 1-like protein.
Length = 893
Score = 70.1 bits (164), Expect = 3e-11
Identities = 94/435 (21%), Positives = 198/435 (45%), Gaps = 40/435 (9%)
Query: 193 INDMRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKD---LQEKLTSNELT 248
I ++ + E K + V +++ + + LE E+ T +D + KLT+ +
Sbjct: 20 IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 79
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
+ QQ+L + E N S+R+ + EL+ +K K+ + + + E L+
Sbjct: 80 NRQLQQKLAALSRQIDELEETNRSLRKAEE-ELQDIKEKISKGEYGNAG-IMAEVEELR- 136
Query: 309 KHNASIESLKNQMLK--EKCEALEQLHSQLIIKEQEMKAKLEQIEES--ASEKLKICEIQ 364
K +E +++K E+C L + + ++ ++ K ++E++ + A EKL+ +
Sbjct: 137 KRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNK 196
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQE-------IKELKYTLDLTNNQNSDLKQELNNLKNC 417
++ S++ + ++ T + L QE IKEL+ LK++L LK
Sbjct: 197 SKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTL 256
Query: 418 KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
E+ E++K +D+L + + E+NK+ EK I+E + S + +
Sbjct: 257 TVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 316
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEY-KEALVN 536
++ +T E + L+++++ A+E N+L + N L N ++ + K+ L N
Sbjct: 317 MYSVT-------KERDDLKNKLK----AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 365
Query: 537 ILKSKAALTKEHTRIMEHNVTLIESLQNVE--KEAYRELGTIKNELI---EDVELLKK-- 589
L + K T + + N + E Q VE K +++ I+++L+ ++ E L++
Sbjct: 366 KLNQDSG--KSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRY 423
Query: 590 -ESNSQIKFLREEVE 603
+ +FL +E+E
Sbjct: 424 ANERDKAQFLSKELE 438
Score = 60.9 bits (141), Expect = 2e-08
Identities = 115/524 (21%), Positives = 227/524 (43%), Gaps = 39/524 (7%)
Query: 9 EPLVAQKNQKKTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXXXXX 68
E V ++ QK T + K+L +++TK + + + K +N + R +
Sbjct: 38 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKL-TNEDSQNRQLQQKLAALSRQIDE 96
Query: 69 XLKFATPKAFKITKAPNSSIKKTLTCPKNK---ILPQDELVQAQDVEIRNKDQTICEYNK 125
+ T ++ + + IK+ ++ + I+ + E ++ + +++ KD+ + + +
Sbjct: 97 LEE--TNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEE 154
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNI---DFNEIDRKLSKLRINNTNCHTEHNAVQ 182
Q D + + K+ + + I + E SK + C+ E +
Sbjct: 155 QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 214
Query: 183 GTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKL 242
+++S + ++ RI ELE L+ + + +L+ L+ + + K + EKL
Sbjct: 215 ---TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKL 271
Query: 243 --TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLD-EEKQAIISKC 299
T ++L A +Q ++E K E + E K ALK+K D EEK ++K
Sbjct: 272 KKTEDKLQAASSQLQVEQNK-----VTTVTEKLIEETK---RALKSKTDVEEKMYSVTK- 322
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK 359
++++LK K A E N +L +L S I++ +K KL Q ++ L
Sbjct: 323 --ERDDLKNKLKAE-EEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALH 379
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEI--KELKY-TLDLTNNQNSDLKQELN-NLK 415
+ +E SQ + E + K ++ +E ++ E +Y TL+ D Q L+ L+
Sbjct: 380 QENNKIKELSQEV-ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 438
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN-KLNLAVEKAIKEKNKFETSLSVT 474
+ K EL+ K+ E+ +T ++ + K + E K+ L+ V+ A+KEK T
Sbjct: 439 HVKMELA--KYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD-ALKEKIH---EYMAT 492
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
D++ L +L Q E++ + L E L EL Y++
Sbjct: 493 EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRH 536
>BC023021-1|AAH23021.1| 731|Homo sapiens golgi autoantigen, golgin
subfamily a, 5 protein.
Length = 731
Score = 70.1 bits (164), Expect = 3e-11
Identities = 89/407 (21%), Positives = 182/407 (44%), Gaps = 31/407 (7%)
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ L NEV E++SL + ++L + E A+ + M +G A
Sbjct: 232 QLLRNEVQSLNQEMASL---LQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVD 288
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCK----VDQENLKTKHNASI-ESLKNQML 322
+ E++ + +L LK +L E Q + ++ + + E + + S SL+NQ L
Sbjct: 289 DLTEAVAAKDS-QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQAL 347
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI---QEHCSQQ 379
+ E L + + L +EQE +Q++ + +L E++ + +++I + S +
Sbjct: 348 QTLQERLHEADATLK-REQE---SYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL--STEKFNFIEEIKTLKD 437
+K + L+Q++K K L+ + + D KQ+ + K++L S ++ + E + +
Sbjct: 404 KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
Query: 438 ELIE-KTINYENEKN-----KLNLAVEKAIKEKNKFETS----LSVTRDIVHVLTLRLRE 487
+E + + +E E KL + + E E R+ + L ++
Sbjct: 464 SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAG 523
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
+ ++LE +++ L +E +L KNTL + +++ DE + L N L +K
Sbjct: 524 QKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSS 583
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRE-LGTIKNELIEDVELLKKESNS 593
+ + L E+L ++K+ E L T KN L+ +E L+++ NS
Sbjct: 584 QSELENRLHQLTETL--IQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
Score = 51.2 bits (117), Expect = 1e-05
Identities = 85/358 (23%), Positives = 166/358 (46%), Gaps = 28/358 (7%)
Query: 135 AQLQEILKELATKFRQ-SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM- 192
AQ+ ++ + +A K Q + + E D+ LS +E + + +E S
Sbjct: 285 AQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQN 344
Query: 193 --INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
+ ++ R+ E + + + E Y KQM+ S + + ++L E +T E +
Sbjct: 345 QALQTLQERLHEADATLKR-EQESY-KQMQ-SEFAARLNKVEMERQNLAEAITLAERKYS 401
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ--ENL-- 306
+ ++R++ ++ L ES ++E I+ + T++ + K+ +I+ K E L
Sbjct: 402 DEKKRVDELQQQVKLYKLNLESSKQEL-IDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
Query: 307 KTKHNASIESLKNQ--MLKEKCEALE-QLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
T + +E L+++ M +E+ + L Q+H QL + Q+M+A+ ESA E+L+
Sbjct: 461 STASSMELEELRHEKEMQREEIQKLMGQIH-QLRSELQDMEAQQVNEAESAREQLQDLHD 519
Query: 364 QFEERSQSIQEHCSQQEKTIQ---YLEQEIKELKYTLDLTNNQNSDLKQELNNLKN--CK 418
Q + S QE ++ E+ Q Y+E+++ K TL ++ D +E+ L+N
Sbjct: 520 QIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQ---SRIKDRDEEIQKLRNQLTN 576
Query: 419 DELSTEKFNFIE-EIKTLKDELIEKTINYEN---EKNKLNLAVEKAIKEKNKFETSLS 472
LS + +E + L + LI+K E+ EKN L +E+ ++ N S S
Sbjct: 577 KTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
>AY644768-1|AAV85456.1| 731|Homo sapiens cell
proliferation-inducing gene 31 protein.
Length = 731
Score = 70.1 bits (164), Expect = 3e-11
Identities = 89/407 (21%), Positives = 182/407 (44%), Gaps = 31/407 (7%)
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ L NEV E++SL + ++L + E A+ + M +G A
Sbjct: 232 QLLRNEVQSLNQEMASL---LQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVD 288
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCK----VDQENLKTKHNASI-ESLKNQML 322
+ E++ + +L LK +L E Q + ++ + + E + + S SL+NQ L
Sbjct: 289 DLTEAVAAKDS-QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQAL 347
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI---QEHCSQQ 379
+ E L + + L +EQE +Q++ + +L E++ + +++I + S +
Sbjct: 348 QTLQERLHEADATLK-REQE---SYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL--STEKFNFIEEIKTLKD 437
+K + L+Q++K K L+ + + D KQ+ + K++L S ++ + E + +
Sbjct: 404 KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
Query: 438 ELIE-KTINYENEKN-----KLNLAVEKAIKEKNKFETS----LSVTRDIVHVLTLRLRE 487
+E + + +E E KL + + E E R+ + L ++
Sbjct: 464 SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAG 523
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
+ ++LE +++ L +E +L KNTL + +++ DE + L N L +K
Sbjct: 524 QKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSS 583
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRE-LGTIKNELIEDVELLKKESNS 593
+ + L E+L ++K+ E L T KN L+ +E L+++ NS
Sbjct: 584 QSELENRLHQLTETL--IQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
Score = 51.2 bits (117), Expect = 1e-05
Identities = 85/358 (23%), Positives = 166/358 (46%), Gaps = 28/358 (7%)
Query: 135 AQLQEILKELATKFRQ-SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM- 192
AQ+ ++ + +A K Q + + E D+ LS +E + + +E S
Sbjct: 285 AQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQN 344
Query: 193 --INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
+ ++ R+ E + + + E Y KQM+ S + + ++L E +T E +
Sbjct: 345 QALQTLQERLHEADATLKR-EQESY-KQMQ-SEFAARLNKVEMERQNLAEAITLAERKYS 401
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ--ENL-- 306
+ ++R++ ++ L ES ++E I+ + T++ + K+ +I+ K E L
Sbjct: 402 DEKKRVDELQQQVKLYKLNLESSKQEL-IDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
Query: 307 KTKHNASIESLKNQ--MLKEKCEALE-QLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
T + +E L+++ M +E+ + L Q+H QL + Q+M+A+ ESA E+L+
Sbjct: 461 STASSMELEELRHEKEMQREEIQKLMGQIH-QLRSELQDMEAQQVNEAESAREQLQDLHD 519
Query: 364 QFEERSQSIQEHCSQQEKTIQ---YLEQEIKELKYTLDLTNNQNSDLKQELNNLKN--CK 418
Q + S QE ++ E+ Q Y+E+++ K TL ++ D +E+ L+N
Sbjct: 520 QIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQ---SRIKDRDEEIQKLRNQLTN 576
Query: 419 DELSTEKFNFIE-EIKTLKDELIEKTINYEN---EKNKLNLAVEKAIKEKNKFETSLS 472
LS + +E + L + LI+K E+ EKN L +E+ ++ N S S
Sbjct: 577 KTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
>AL096710-6|CAI22047.1| 2649|Homo sapiens dystonin protein.
Length = 2649
Score = 70.1 bits (164), Expect = 3e-11
Identities = 113/515 (21%), Positives = 225/515 (43%), Gaps = 57/515 (11%)
Query: 126 QIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTD 185
Q E K + +L++ + EL R++ D E+ +L+ L++ T+ + ++
Sbjct: 1353 QQEHDKQKAEELKQQVDELTAANRKAEQ--DMRELTYELNALQLEKTSSEEKARLLK--- 1407
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQM-ELS--------SLEEVITVRDSLCK 236
+K+ N +R +ELE+K +A + Y +Q+ EL EE + L K
Sbjct: 1408 -DKLDETNNTLRCLKLELERKDQA--EKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKK 1464
Query: 237 ---DLQEKLTSNELTLAETQQRLEMVKGHHALALEAN--------ESIRREYKIEL---- 281
+ Q +L S + Q+ ++ + HA+A E N S R E ++E
Sbjct: 1465 IKRNYQLELESLNHEKGKLQREVDRITRAHAVA-EKNIQHLNSQIHSFRDEKELERLQIC 1523
Query: 282 ----EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN----QMLKEKCEALEQLH 333
+ LK + ++ + ++ K ++EN + E K+ +MLK+K E L + +
Sbjct: 1524 QRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQN 1583
Query: 334 SQLIIKEQEMKAKLEQIE------ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLE 387
++ + Q ++A+ E I + E LKI F+++ +S EH +Q KT Q +
Sbjct: 1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ 1643
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL---IEKTI 444
++IK L+ L + N S+ KQ+ + E N E+ K+E +K
Sbjct: 1644 RKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ 1703
Query: 445 NYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS 504
+ + +LN ++K E + +T + + + E+ +++ L
Sbjct: 1704 LQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME 1763
Query: 505 AKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQN 564
+K + EN+++ + + +E +E K KE R ++ ++ Q+
Sbjct: 1764 SKVITENDISGIRLDFVSLQQENSRAQEN----AKLCETNIKELERQLQQYREQMQQGQH 1819
Query: 565 VEKEAYRELGTIKNELI---EDVELLKKESNSQIK 596
+E Y++ +++ELI +VE LK++ + QIK
Sbjct: 1820 MEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
Score = 66.1 bits (154), Expect = 4e-10
Identities = 97/481 (20%), Positives = 203/481 (42%), Gaps = 35/481 (7%)
Query: 184 TDAEKVSAMINDMRSRIIE-LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKL 242
++ E++ A + +SR+ E L K EA +NE+ +Q + + +S K + +L
Sbjct: 1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200
Query: 243 TSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK------QAII 296
+ ++ LE V+ L +EA E+ R + L + +L+E + +
Sbjct: 1201 ETIVREKEAAERELERVR---QLTIEA-EAKRAAVEENLLNFRNQLEENTFTRRTLEDHL 1256
Query: 297 SKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLEQIEESA 354
+ + +L+ + N +E L+ + E+ + ++Q+ L ++Q + +L++ ++
Sbjct: 1257 KRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIE 1316
Query: 355 SE-KLKICEIQFEERSQSIQEHCSQQE---KTIQYLEQE-----IKELKYTLDLTNNQNS 405
E + KI EIQ+ R ++ Q + + L+QE +ELK +D N
Sbjct: 1317 LEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANR 1376
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
+Q++ L + L EK + E+ + LKD+L E N L L +E+ + +
Sbjct: 1377 KAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN----NTLRCLKLELERKDQAEK 1432
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ L L +L ++ + E+ + L K + EL + + R
Sbjct: 1433 GYSQQL-------RELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQR 1485
Query: 526 ECDEYKEALVNILKSKAALTKE-HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E D A K+ L + H+ E + ++ Q + +L++++
Sbjct: 1486 EVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNI 1545
Query: 585 ELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN 644
+ +KE+N +I+ L EE+EK EM +++++ + A+ + E
Sbjct: 1546 KA-EKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK 1604
Query: 645 E 645
+
Sbjct: 1605 Q 1605
Score = 65.3 bits (152), Expect = 7e-10
Identities = 100/513 (19%), Positives = 226/513 (44%), Gaps = 49/513 (9%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ----LQEILKELATKFRQS 151
K+K+ + ++ +E+ KDQ Y++Q+ + ++ Q +E ++E + +
Sbjct: 1407 KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 1466
Query: 152 HN-NIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMR-SRIIELEKKCEA 209
N ++ ++ + KL+ + T +AV + + +++ I+ R + +E + C+
Sbjct: 1467 RNYQLELESLNHEKGKLQ-REVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525
Query: 210 LDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGH-HALALE 268
+ + +Q E S + + ++ K+ +K+ L ++ + EM+K L +
Sbjct: 1526 KSDHL-KEQFEKSHEQLLQNIKAE--KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ 1582
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
NE+ +I+ E+ L EKQ I +C E LK + + K+Q+
Sbjct: 1583 NNETKLMMQRIQAESENIVL--EKQTIQQRC----EALKIQ----ADGFKDQLRSTN--- 1629
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
E LH Q EQ+ + K++ +EE ++ + +F+++ C QQ IQ ++
Sbjct: 1630 -EHLHKQ-TKTEQDFQRKIKCLEEDLAKSQNLVS-EFKQK-------CDQQNIIIQNTKK 1679
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEE--IKTLKDELI-EKTIN 445
E++ L L+ + + +Q++ + EL+ +E +KT+++++ K +
Sbjct: 1680 EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVL 1739
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
++ E K + E+ K+ K S +T + + + L E + ++ ++ +
Sbjct: 1740 FQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETN 1799
Query: 506 KEVLENELTTYKNTLN-------NTVRECDEYKEALVNILKSKAAL-TKEHTRIMEHNVT 557
+ LE +L Y+ + N ++C + ++ L+ + L K +I EH
Sbjct: 1800 IKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQ 1859
Query: 558 LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
L+ ++K++ + T K D E+ KE
Sbjct: 1860 LVLLQCEIQKKSTAKDCTFK----PDFEMTVKE 1888
Score = 55.6 bits (128), Expect = 6e-07
Identities = 91/491 (18%), Positives = 201/491 (40%), Gaps = 39/491 (7%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSK 166
QA + ++ + +CE I D KN I L LK+ ++ + F+ ++ +L K
Sbjct: 856 QAAEALVKLYETKLCEEEAVIAD-KNNIENLISTLKQWRSEVDEKRQV--FHALEDELQK 912
Query: 167 LRINNTNC---HTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC---EALDNEVYDKQME 220
+ + + E + EK ++ ++ ++++ + E + + +
Sbjct: 913 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
L++ I ++ + +QE N TLA + +M+ + + ++ Y +
Sbjct: 973 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK-YAEQ 1031
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKE 340
A T D E Q + + VD + ++S + +++E + + + + +
Sbjct: 1032 YSA--TVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMT 1089
Query: 341 QEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTI---QYLEQEIKELKYTL 397
Q +K + ++ E++K C+ E + S + +Q+ T+ L +I EL+ +
Sbjct: 1090 QYIKFAGDSLKRLEEEEIKRCKETSEHGAYS--DLLQRQKATVLENSKLTGKISELERMV 1147
Query: 398 DLTNNQNSDLKQELNNLKNC-KDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
Q S +++EL ++ ++EL ++ N +E+I K I E+E +
Sbjct: 1148 AELKKQKSRVEEELPKVREAAENELRKQQRN-VEDISLQK-------IRAESEAKQYRRE 1199
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE------ 510
+E ++EK E L R + + + L +Q++ T + LE
Sbjct: 1200 LETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRK 1259
Query: 511 ----NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
N+L KN L +R + +E L+ ++K ++ E ++ Q +E
Sbjct: 1260 DLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ---LKEKQKIE 1316
Query: 567 KEAYRELGTIK 577
EA R++ I+
Sbjct: 1317 LEARRKITEIQ 1327
>AF085199-1|AAD09753.1| 731|Homo sapiens golgin-84 protein.
Length = 731
Score = 70.1 bits (164), Expect = 3e-11
Identities = 89/407 (21%), Positives = 182/407 (44%), Gaps = 31/407 (7%)
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ L NEV E++SL + ++L + E A+ + M +G A
Sbjct: 232 QLLRNEVQSLNQEMASL---LQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVD 288
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCK----VDQENLKTKHNASI-ESLKNQML 322
+ E++ + +L LK +L E Q + ++ + + E + + S SL+NQ L
Sbjct: 289 DLTEAVAAKDS-QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQAL 347
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI---QEHCSQQ 379
+ E L + + L +EQE +Q++ + +L E++ + +++I + S +
Sbjct: 348 QTLQERLHEADATLK-REQE---SYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL--STEKFNFIEEIKTLKD 437
+K + L+Q++K K L+ + + D KQ+ + K++L S ++ + E + +
Sbjct: 404 KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
Query: 438 ELIE-KTINYENEKN-----KLNLAVEKAIKEKNKFETS----LSVTRDIVHVLTLRLRE 487
+E + + +E E KL + + E E R+ + L ++
Sbjct: 464 SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAG 523
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
+ ++LE +++ L +E +L KNTL + +++ DE + L N L +K
Sbjct: 524 QKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSS 583
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRE-LGTIKNELIEDVELLKKESNS 593
+ + L E+L ++K+ E L T KN L+ +E L+++ NS
Sbjct: 584 QSELENRLHQLTETL--IQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
Score = 51.2 bits (117), Expect = 1e-05
Identities = 85/358 (23%), Positives = 166/358 (46%), Gaps = 28/358 (7%)
Query: 135 AQLQEILKELATKFRQ-SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAM- 192
AQ+ ++ + +A K Q + + E D+ LS +E + + +E S
Sbjct: 285 AQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQN 344
Query: 193 --INDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA 250
+ ++ R+ E + + + E Y KQM+ S + + ++L E +T E +
Sbjct: 345 QALQTLQERLHEADATLKR-EQESY-KQMQ-SEFAARLNKVEMERQNLAEAITLAERKYS 401
Query: 251 ETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQ--ENL-- 306
+ ++R++ ++ L ES ++E I+ + T++ + K+ +I+ K E L
Sbjct: 402 DEKKRVDELQQQVKLYKLNLESSKQEL-IDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
Query: 307 KTKHNASIESLKNQ--MLKEKCEALE-QLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
T + +E L+++ M +E+ + L Q+H QL + Q+M+A+ ESA E+L+
Sbjct: 461 STASSMELEELRHEKEMQREEIQKLMGQIH-QLRSELQDMEAQQVNEAESAREQLQDLHD 519
Query: 364 QFEERSQSIQEHCSQQEKTIQ---YLEQEIKELKYTLDLTNNQNSDLKQELNNLKN--CK 418
Q + S QE ++ E+ Q Y+E+++ K TL ++ D +E+ L+N
Sbjct: 520 QIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQ---SRIKDRDEEIQKLRNQLTN 576
Query: 419 DELSTEKFNFIE-EIKTLKDELIEKTINYEN---EKNKLNLAVEKAIKEKNKFETSLS 472
LS + +E + L + LI+K E+ EKN L +E+ ++ N S S
Sbjct: 577 KTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
>AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome associated
protein protein.
Length = 2442
Score = 70.1 bits (164), Expect = 3e-11
Identities = 101/488 (20%), Positives = 202/488 (41%), Gaps = 20/488 (4%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEID 161
Q +++ Q +E+ KDQ I Q++D K ++ L+ LA + ++H+ + E
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE----CLALELEENHHKM---ECQ 1572
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+KL K D E+ S + S+I +LE L E+ ++ E+
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV 1632
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
S E I + L + L + L ++R+++++ + E + K+ L
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+L ++Q + + + + K + S+E +K +L++K + +E + I + Q
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQ-RGSLEHMK-LILRDKEKEVE-CQQEHIHELQ 1749
Query: 342 EMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTN 401
E+K +LEQ + K+ + +R Q I Q ++ + E + + L+ LD
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 402 NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA- 460
+ QEL L+ + + ++ E+ L+ L + + + +L E+A
Sbjct: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR 1869
Query: 461 -IKEKNKFE-TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
++E+ E + +++ L RE + L L+ Q EV L
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWL 1929
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKN 578
++E D+ EAL +S+++ +E E E+LQ +A+ L +
Sbjct: 1930 QAQAVLKERDQELEAL--RAESQSSRHQE-----EAARARAEALQEALGKAHAALQGKEQ 1982
Query: 579 ELIEDVEL 586
L+E EL
Sbjct: 1983 HLLEQAEL 1990
Score = 69.7 bits (163), Expect = 3e-11
Identities = 117/513 (22%), Positives = 228/513 (44%), Gaps = 55/513 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
+Q E + + + E N +E ++ + +E EL R + EI +KLS
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEA---QLQKAEEAGAELQADLRDIQEEKE--EIQKKLS 697
Query: 166 KLRINNTNCHTEHNAV--QGTDAEKVSAMINDMRSRIIELEKKCEA-LDNEVYDKQMELS 222
+ R T+ + + E+V A + ++ + E L D+Q +
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAA 757
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L+ + + ++ L L E N + + E Q +LE+ A E + R K+EL+
Sbjct: 758 QLQGLSSAKELLESSLFEAQQQNSV-IDEPQGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816
Query: 283 ALKTKLDEEKQAIISKCKVDQENLKT---KHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+++ ++E+ A + ++ KT + A+ E NQ L+EK E H Q + K
Sbjct: 817 TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAK 875
Query: 340 EQEM----KAKLE-QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELK 394
E K +LE +++E +E I + EER+Q+ C Q +T E+E L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET----EKERVSLL 931
Query: 395 YTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIE--KTINYENEKNK 452
TL T + +D Q+L L+ ++ +K E L+ +L E + + +++
Sbjct: 932 ETLLQTQKELADASQQLERLRQ---DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 453 LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE 512
+LA A++E+ S S+ +D + + ++E L+ Q+ ++ ++E E
Sbjct: 989 DDLA---ALQEE-----SSSLLQDKMDL--------QKQVEDLKSQLVAQDDSQRLVEQE 1032
Query: 513 LTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE 572
+ +RE EY + + KA+LT +ME L+ LQ + +E
Sbjct: 1033 V-------QEKLRETQEYNRIQKELEREKASLTLS---LMEKEQRLLV-LQEADSIRQQE 1081
Query: 573 LGTIKNELIEDVELLKKESNSQIKFLREEVEKK 605
L ++ ++ ++ + +KE ++Q++ LR+EV++K
Sbjct: 1082 LSALRQDM-QEAQGEQKELSAQMELLRQEVKEK 1113
Score = 66.1 bits (154), Expect = 4e-10
Identities = 101/519 (19%), Positives = 233/519 (44%), Gaps = 42/519 (8%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA 186
++D + ++A QE + L + Q + + ++L KL + +QG +
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEE--EGKALRQRLQKLTGERDTLAGQTVDLQG-EV 458
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +S ++ EL ++ E L+ E + ++ ++E + DS +E+
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLEQEAW--RLRRVNVELQLQ-GDSAQGQKEEQQEELH 515
Query: 247 LTLAETQQRLEMVKGHHALALEA-NESIRREYKIELEALKTKLDEEKQAIISKCKVDQEN 305
L + E ++ EM+ G A E+ +E I +E L+ +L ++Q ++ E
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESIHLEGELLRQEQTEVTAALARAEQ 575
Query: 306 LKTKHNASIESLKNQMLK-----EKCEALEQ--------LHSQLIIKEQEMKAKLEQIE- 351
+ ++S +LK ++ K AL + L+ QL+ E+E ++ ++E
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 352 -ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE 410
E A L++ + E+R +++ E + E +Q E+ EL+ L + +++++
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 411 LNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE---NEKNKLNLAVEKAIKEKNKF 467
L+ ++ ++ +T+ +E K ++ L E EK L + ++ +++
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 468 ETSL---SVTRDIVHVLTLRLRESDSELE----QLEDQVQMLTSAKEVLENELTTYKNTL 520
L S ++++ ++ +S ++ QLE Q+Q +T AKEV++ E+ K L
Sbjct: 756 AAQLQGLSSAKELLESSLFEAQQQNSVIDEPQGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 521 NNTVRECDEYKEALVNIL-----KSKAALTKEHTRIMEHNVTLIESLQNV----EKEAYR 571
+ + ++ ++A L + K AL ++ + L E + ++E +
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 572 ELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
L +++ E +E +E+ KE ++++ ++ + E++R E
Sbjct: 876 ALESLEREKME-LEMRLKEQQTEMEAIQAQREEERTQAE 913
Score = 66.1 bits (154), Expect = 4e-10
Identities = 103/510 (20%), Positives = 219/510 (42%), Gaps = 28/510 (5%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
EL Q +N+++ KQ ++E+ +L E + L ++ R++ + +R+
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQ-NSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
L + N EH +A ++ + + + + EV ++ +
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
L+E ++ + K LQE L TLAE ++ +E ++G ++ E R K LE
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ----IQELEKQREMQKAALEL 1460
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
L L + Q + + + QE K + + +E L ++E+ + L Q+ E++
Sbjct: 1461 LSLDLKKRNQEVDLQQEQIQELEKCR--SVLEHLP-MAVQEREQKLTVQREQIREPEKDR 1517
Query: 344 KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQ 403
+ + +E E K ++ +R Q +Q+ +Q T++ L E++E + ++
Sbjct: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQ-VQD-LKKQLVTLECLALELEENHHKMECQQKL 1575
Query: 404 NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE 463
+L+ + + L+ + +E++ ++ + E+ L +++ +E
Sbjct: 1576 IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD----LESHSTVLARELQERDQE 1631
Query: 464 -KNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQML----TSAKEVLENELTTYKN 518
K++ E + R H LT L D EL ++++Q+L T ++LE +L K
Sbjct: 1632 VKSQREQIEELQRQKEH-LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKN 578
+L RE ++ + + +K +EH + LI L++ EKE +
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH-MKLI--LRDKEKEV-----ECQQ 1742
Query: 579 ELIEDVELLKKESNSQIKFLREEVEKKRVL 608
E I +++ LK + Q++ L +V + +L
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Score = 59.7 bits (138), Expect = 4e-08
Identities = 82/412 (19%), Positives = 174/412 (42%), Gaps = 22/412 (5%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK--------ELATKFRQSHNNI 155
EL+++ E + ++ I E Q+E + Q +E+++ EL T+ Q+
Sbjct: 767 ELLESSLFEAQQQNSVIDEPQGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEV 214
D R+L++ + A + ++ RS EL K E+L+ E
Sbjct: 827 D--AAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREK 884
Query: 215 YDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIR 274
+ +M L +E T +++ +E+ T E L + Q E + L +
Sbjct: 885 MELEMRL---KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
+ +LE L+ + +K + Q L+ E+ + ++ AL++ S
Sbjct: 942 ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH--RDDLAALQEESS 999
Query: 335 QLIIKEQEMKAKLEQIEE---SASEKLKICEIQFEERSQSIQEHCSQQ---EKTIQYLEQ 388
L+ + +++ ++E ++ + + ++ E + +E+ + QE+ Q E+ L
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ E + L + +S +QEL+ L+ E E+ +++ L+ E+ EK ++
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQ 500
++ +L +E + + + SL L LRLR ++S+LE L + Q
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLHLRLRSTESQLEALAAEQQ 1171
Score = 58.8 bits (136), Expect = 6e-08
Identities = 107/515 (20%), Positives = 225/515 (43%), Gaps = 78/515 (15%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
+D E+ Q + Q E K + LQ L++ ++ H + D K R
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ----DHKEQARR 1870
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDK----QMELSSL 224
+ E AV+G + + ++ D+R+ E EK AL + ++ ++E +L
Sbjct: 1871 LE------EELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 225 EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI---------RR 275
++ ++ K+ ++L E AE+Q + A A E++ +
Sbjct: 1925 QDSWLQAQAVLKERDQEL---EALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKE 1981
Query: 276 EYKIELEALKTKLDEEK---QAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQL 332
++ +E L L+ QA + C+ L+ +++Q L+ + E ++QL
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ-EDVQQL 2040
Query: 333 HSQLIIKEQEMKAKLEQ---IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQE 389
L +++E++ + E+ +E+S +++++ IQ E+++ ++ ++E+ I+ L Q
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ-EKQNLGLE----REEEEIRGLHQS 2095
Query: 390 IKELKYTLDLTNNQNSDLK--QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
++EL+ TL + +L+ Q+ NNL+ T E ++LK + +E + E
Sbjct: 2096 VRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPM----EEQSLKLDSLEPRLQRE 2151
Query: 448 NEKNKLNLAVEKA--IKEKNKFE----------TSLSVTRDIVHVLTLRLRESDSELEQL 495
E+ + L +A I+ + K + S+S +++ L + E DSE ++L
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 496 EDQVQMLTSA--KEVLENELTTYKNTLNNTVR--------------------ECDEYKEA 533
+D++++ A KE L + T L + E +++
Sbjct: 2212 QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQR 2271
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L ++ ++ A L + +R+ HNV L +L+ VE+E
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERE 2306
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/443 (19%), Positives = 181/443 (40%), Gaps = 33/443 (7%)
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK 359
K+ Q+ KT+ + + Q L+E+ E SQ+ + Q+++ +L Q +E S K +
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-KWE 1305
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
+ E + E + + ++ E + E + +L +L ++ +L+
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 420 ELSTEKF--NFIEE-IKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS-VTR 475
E + +EE ++T + L K E+E+ + +A++E+ + + + +
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERA-----QALQEQGELKVAQGKALQ 1420
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+ + +LT L E + E+E L Q+Q L +E+ + L L +E D +E +
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 536 NILKSKAALTKEHTRIMEHNVTLI---ESLQNVEKEAYRELGTIKNELIE---------- 582
+ K ++ L + E L E ++ EK+ + ++++L+E
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIREPEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 583 ---DVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSR 639
V+ LKK+ + ++ L E+E+ E RV L D
Sbjct: 1541 QRGQVQDLKKQLVT-LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD--- 1596
Query: 640 LENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSP 699
LE ++ L ++L +E +E V Q I++L++ Q ++ +
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR---QKEHLTQDL 1653
Query: 700 SVLRKSLKVGKENMQTISPLRER 722
+ L + KE +Q + R R
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTR 1676
Score = 54.8 bits (126), Expect = 1e-06
Identities = 79/380 (20%), Positives = 158/380 (41%), Gaps = 18/380 (4%)
Query: 357 KLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKN 416
K + E + ERSQ + + SQ + L+ + EL L + QN D ++ + L+
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 417 CKDELSTEKFNFIEEIKTLKDELIEKTINYENE-KNKLNLAVEKA--IKEKNKFETSLSV 473
+ L T +E +L E+ ++ + K+ + VE+ I + + E SL +
Sbjct: 312 TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGLENSLEL 371
Query: 474 TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEA 533
I +++D L + + A + L +L + +N ++ D+++E
Sbjct: 372 ESSIFS--QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEE 429
Query: 534 LVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE-LGTIKNELIEDVELLKKESN 592
+ + LT E + V L + ++ KE RE L + EL + +E+L++E+
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE--RELLQKAREELRQQLEVLEQEA- 486
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENEN-ERYXXXX 651
+++ + E++ + + R L + L ++E+
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 652 XXXXSLVVELSLLRQENEELT-------MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRK 704
S+ +E LLRQE E+T ++A+ SS + LK ++ + S L +
Sbjct: 547 EALESIHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 705 SLKVGKENM-QTISPLRERN 723
+L + K + Q + L E N
Sbjct: 607 ALALDKVGLNQQLLQLEEEN 626
Score = 44.4 bits (100), Expect = 0.001
Identities = 60/301 (19%), Positives = 127/301 (42%), Gaps = 14/301 (4%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E ++ Q+ EI+++D Y + ++ + +AQ E L+ + + ++ +
Sbjct: 2016 EEALRIQEGEIQDQD---LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 163 KLSKLRINNTNCHTEHNAVQGT--DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME 220
+ + + N E ++G ++ + I+EL + + + E +
Sbjct: 2073 MIQEKQ--NLGLEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR-LEMVKGHHALAL-----EANESIR 274
S +EE DSL LQ +L + L +T+ R +E + LAL +A+ S
Sbjct: 2131 TSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Query: 275 REYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHS 334
+E + L+A + D E+Q + + ++ + L+ + S + L + E QL
Sbjct: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGE 2250
Query: 335 QLIIKEQEMKAKLE-QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKEL 393
++ + +E Q E L+ + E +Q H Q T++ +E+E ++L
Sbjct: 2251 VSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
Query: 394 K 394
K
Sbjct: 2311 K 2311
Score = 42.3 bits (95), Expect = 0.006
Identities = 92/444 (20%), Positives = 180/444 (40%), Gaps = 45/444 (10%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R +E++ + E+ + + LS +R ++ +E S + E Q L
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 257 EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIES 316
++ L EA+E + EL LK++ D EK + + + L T+ E
Sbjct: 248 LLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRV-TELSALLTQSQKQNED 301
Query: 317 LKNQM--LKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLK-ICEIQFEERSQSIQ 373
+ + L+E E LE H++L+ E + ++ + S + +K I ++ EE Q
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 374 ----EHCSQQEKTI------QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELST 423
E+ + E +I Q ++ + ++ L DL+Q+L + + L
Sbjct: 362 GSGLENSLELESSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
Query: 424 EKFNFIEEIKTL----------KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSV 473
+ + EE K L +D L +T++ + E + L+ E K + + L V
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 474 -------TRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRE 526
R + L L+ + + E+ ++++ + +E L+ L + + ++ E
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541
Query: 527 CDEYKEALVNILKSKAALTKEHTRI------MEHNVTLIESLQNVEKEAYREL--GTIK- 577
+EAL +I L +E T + E ++ + S +N K +L +K
Sbjct: 542 LITLREALESIHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL 601
Query: 578 NELIEDVELLKKESNSQIKFLREE 601
+ L E + L K N Q+ L EE
Sbjct: 602 SALNEALALDKVGLNQQLLQLEEE 625
>Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein.
Length = 1356
Score = 69.7 bits (163), Expect = 3e-11
Identities = 92/455 (20%), Positives = 203/455 (44%), Gaps = 41/455 (9%)
Query: 184 TDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDL---- 238
T+ E+ + ++ M+ RI LEK+ N+++ E ++ + VR+ + ++
Sbjct: 363 TEKERSNVVMTRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 422
Query: 239 QEK-----LTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQ 293
QE SN E++Q E+ K A NE + K++ E ++ K + E+
Sbjct: 423 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKK-NAEQA 481
Query: 294 AIISKCKVDQENLK------------TKHNASIESLKNQMLKEKCEALEQLHSQL---II 338
A K ++ + + +H A+ + L+++ + ++ E ++ LHS+L ++
Sbjct: 482 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENE-VQSLHSKLTDTLV 540
Query: 339 KEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLD 398
+Q+++ +L Q+ ES +++ E + + Q I E + IQ +I
Sbjct: 541 SKQQLEQRLMQLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 599
Query: 399 LTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN-LAV 457
L + + ++ +K +D L++E+ + + LKD + + E KL LA
Sbjct: 600 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN 658
Query: 458 EKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT 515
E+A E K + S+ V D + +L +L+ E+ ++ ++L + L++E+
Sbjct: 659 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQK 715
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
+ ++ + + E + ++ K K ++E + + + ++E + T
Sbjct: 716 LQTLVSEQPNK--DVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAIRT 769
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ L ++V+ LK + N Q+ F E K+V+ E
Sbjct: 770 ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 804
Score = 68.9 bits (161), Expect = 6e-11
Identities = 112/569 (19%), Positives = 254/569 (44%), Gaps = 66/569 (11%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA- 145
+KK + KI +EL++A+ +++ NK++T+ + ++I+ K EI +Q E ++L+
Sbjct: 798 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 857
Query: 146 -TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA----EKVSAMINDMRSRI 200
+K ++ N + E K + + D E + A + ++
Sbjct: 858 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 917
Query: 201 IE---LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKD----LQEKLTSNELTLAETQ 253
++ + E L+ + +K EL LE ++ R+S LQ+ N+L ++ +
Sbjct: 918 LKEASSASQFEELEIVLKEKGNELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 977
Query: 254 QRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
Q L+ A + +E + + E + E+ L +LD K A+ + K + + L+ K+
Sbjct: 978 Q-LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND-LREKN 1035
Query: 311 NASIESLK----------NQMLKEKCEALE--QLHSQLIIKEQ----------------- 341
++E+L N+ KE+ + +E +L ++ ++K+
Sbjct: 1036 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1095
Query: 342 --EMKAKLEQIEESASEKLKICEIQFEERSQS---IQEHCSQQEKTIQYLEQEIKELKYT 396
E KAK S SE++K+ E + +E + +Q C + + + E +++L+ +
Sbjct: 1096 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1155
Query: 397 LDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTI-NYENEKNKLN 454
++ N+ + + +K + ++ + +E++ L+ E K I N E+ L
Sbjct: 1156 VEQEENKWKVKVDESHKTIKQMQSSFTSSE----QELERLRSE--NKDIENLRREREHLE 1209
Query: 455 LAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELT 514
+ +EKA E++ + T + +D++ L +L +S SE + +++ +L + +L
Sbjct: 1210 MELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR 1269
Query: 515 TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELG 574
T +N + + +++L +++SK T ++E N + ++ EKE +
Sbjct: 1270 TEQNERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIE-NSDVSPETESSEKET---MS 1324
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVE 603
N+ + ++ L + N Q+ +E +
Sbjct: 1325 VSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1353
Score = 47.6 bits (108), Expect = 2e-04
Identities = 73/337 (21%), Positives = 144/337 (42%), Gaps = 27/337 (8%)
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++++ K EL L +L +EK +++ K D K + + L +M+ EK
Sbjct: 316 DALKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDR----CKQLTQEMMTEK----- 365
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + ++ + ++ LE+ K+ + + ++ Q+ Q E I +L+QE
Sbjct: 366 ERSNVVMTRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN 425
Query: 391 KELKYTLDLTNNQ-NSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENE 449
L+ + T NQ S ELN L+ L E E+ L+ E ++K N E
Sbjct: 426 GILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQKK-NAEQA 481
Query: 450 KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVL 509
+L + +++A + ++E S R ++ S+ E++VQ L S L
Sbjct: 482 ATQLKVQLQEA---ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK---L 535
Query: 510 ENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEA 569
+ L + K L + + E ++ VN + +L + I+E N L +Q +
Sbjct: 536 TDTLVS-KQQLEQRLMQLMESEQKRVN---KEESLQMQVQDILEQNEALKAQIQQFHSQI 591
Query: 570 YRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ T + L E++ + E + QIK + + +R
Sbjct: 592 AAQ--TSASVLAEELHKVIAEKDKQIKQTEDSLASER 626
Score = 33.1 bits (72), Expect = 3.6
Identities = 58/283 (20%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 298 KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
K + D+EN + K + SLK M E EAL + ++KE+ + + +++S+ +
Sbjct: 271 KTETDKENAEVKFKDFLLSLKTMMFSED-EALCVVD---LLKEKSGVIQ-DALKKSSKGE 325
Query: 358 LKICEIQFEERSQ---SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD----LKQE 410
L Q +E+ + +++E + + + L QE+ K ++ + D L++E
Sbjct: 326 LTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVMTRMKDRIGTLEKE 385
Query: 411 LNNLKNCKDELSTEKFNFIE-EIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFE 468
N +N K +S ++ ++ + + +++++ + + + E L AV + ++K
Sbjct: 386 HNVFQN-KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 444
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK---NTLNNTVR 525
L+ R L L E +L+Q E Q + A L+ +L + + + +R
Sbjct: 445 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 504
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEHNVT-LIESLQNVEK 567
+ EA L+SK + + + +T + S Q +E+
Sbjct: 505 KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 547
>X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa
protein.
Length = 976
Score = 69.7 bits (163), Expect = 3e-11
Identities = 111/535 (20%), Positives = 222/535 (41%), Gaps = 42/535 (7%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
K +I +++ V ++I K+ + + +E+ ++++ QL+E K + +QS
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEK- 316
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQG--TDAEKVSAMINDMRSRIIELEKKCEALDNE 213
+ + ++L ++++ + A++ A K + + + +E K A +
Sbjct: 317 -QHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSF 375
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESI 273
V ++ E + + L + Q++L NE L L+ LE +
Sbjct: 376 V------VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSE----LEEMTKL 425
Query: 274 RREYKIELEALKTKLDEEKQAIISKCKVDQ--ENLKTKHNASIESLKNQMLKEKCEALEQ 331
++ELE LK L E++ + + ++ E LK I L Q +++ LE
Sbjct: 426 TNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLL--QAREKEVHDLEI 483
Query: 332 LHSQLIIKEQEMKAKLEQIE-ESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ + EQ +++ ++ E +EKLK E+ S++ QE + L E+
Sbjct: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTL--EL 541
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
K + ++ Q + +++ NL+ + +L E EE+K +DE+ K E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 451 NKLNLAVE-------------KAIKEKNKFET-SLSVTRDIVHVLTLRLRESDSELEQLE 496
N L VE KA+K+K E+ L+V V+ L L L + + ++
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 497 DQVQMLTSAKEVLE----NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
D Q K++ E E+ K + V+ E + + + AL ++H
Sbjct: 662 DTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQY 721
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNS---QIKFLREEVEK 604
+ + +S + K +E +++ L ++ LK E S Q++ REE EK
Sbjct: 722 DKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEK 776
Score = 69.3 bits (162), Expect = 4e-11
Identities = 112/517 (21%), Positives = 228/517 (44%), Gaps = 40/517 (7%)
Query: 110 DVEIRNKDQTICEYNKQIEDYKNEIAQLQ----EILKELATKFRQSHNNIDFNEIDRKLS 165
+ E+R K+ + E K IE + I +LQ ++ +L +++ + I N R L
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
Query: 166 KLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL---- 221
L E + E+ + D+ + I ++ L + + ++E+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAHGELRVQAENSRLEMHFKL 243
Query: 222 -SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR-EYKI 279
E++ + K++ +K L L + ++ +K L E+ + + + E K
Sbjct: 244 KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 280 ELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIK 339
+L++ K EKQ ++K + E++K S+ + K L+E + + QL +
Sbjct: 304 KLQSENLKQSIEKQHHLTK---ELEDIKVSLQRSVSTQK--ALEEDLQIATKTICQL-TE 357
Query: 340 EQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDL 399
E+E + + E + A+ + E FE S++E +++ ++ E ++K L T++L
Sbjct: 358 EKETQME-ESNKARAAHSFVVTE--FETTVCSLEELLRTEQQRLEKNEDQLKIL--TMEL 412
Query: 400 TNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEK 459
++S+L +E+ L N K+ E +EE+K + E ++T+ YEN+ + E+
Sbjct: 413 -QKKSSEL-EEMTKLTNNKE---VE----LEELKKVLGE--KETLLYENK--QFEKIAEE 459
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTS--AKEVLEN-ELTTY 516
+ + L VH L ++L + + +V+ L + E L+N ELT++
Sbjct: 460 LKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
N L+ +E + + LK++ + + E + IE+LQ E + EL +
Sbjct: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
Query: 577 KNEL---IEDVELLKKESNSQIKFLREEVEKKRVLCE 610
+ EL ++V+ +S LR++VE K E
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Score = 69.3 bits (162), Expect = 4e-11
Identities = 111/528 (21%), Positives = 228/528 (43%), Gaps = 43/528 (8%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNI 155
++K+ +E + Q ++ + K++ED K + + K L + + I
Sbjct: 293 RDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTI 352
Query: 156 DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK---KCEALDN 212
+ K +++ +N H+ V V ++ +R+ LEK + + L
Sbjct: 353 -CQLTEEKETQMEESN-KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQR---LEMVKGHHALA--- 266
E+ K EL + ++ ++ ++L++ L E L E +Q E +KG
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
Query: 267 LEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
L+A E + +I+L A+ T ++ + K + EN E LKN L C
Sbjct: 471 LQAREKEVHDLEIQLTAITTS-EQYYSKEVKDLKTELEN---------EKLKNTELTSHC 520
Query: 327 EALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYL 386
L + +L + +M +L+ +E + K E + ++ +++QE +Q ++Y+
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-EERMLKQIENLQETETQLRNELEYV 579
Query: 387 EQEIK----ELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+E+K E+K LD + ++L++++ N +EL E + +K K K
Sbjct: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN----KALKK-KGTAESK 634
Query: 443 TIN-YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+N YE + NKL L +E A K KF +T + + ++ LE++E + ++
Sbjct: 635 QLNVYEIKVNKLELELESA---KQKFG---EITDTYQKEIEDKKISEENLLEEVE-KAKV 687
Query: 502 LTSAKEVLENELTTY-KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ L+ E+ ++ + V +++K I++ + + + + +L
Sbjct: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRA 747
Query: 561 SLQNVEKEAYRELGTIKNELI---EDVELLKKESNSQIKFLREEVEKK 605
SL+ EL ++K +L E+ E LK+E+ L+E+ +KK
Sbjct: 748 SLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKK 795
Score = 62.1 bits (144), Expect = 7e-09
Identities = 105/487 (21%), Positives = 214/487 (43%), Gaps = 53/487 (10%)
Query: 143 ELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEK----VSAMINDMRS 198
E+ K ++ + I E + K IN+ +Q T+ E ++ ++ + R
Sbjct: 238 EMHFKLKEDYEKIQHLEQEYKKE---INDKEKQVSLLLIQITEKENKMKDLTFLLEESRD 294
Query: 199 RIIELEKKCEALDNEV---YDKQMELSS-LEEV-ITVRDSLC--KDLQEKLTSNELTLAE 251
++ +LE+K + + +KQ L+ LE++ ++++ S+ K L+E L T+ +
Sbjct: 295 KVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQ 354
Query: 252 TQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIIS---KCKVDQENLKT 308
+ E A A+ + E++ + +L+ L E+Q + + K+ L+
Sbjct: 355 LTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQK 414
Query: 309 KHNASIESLKNQMLKE-KCEALEQLHSQ---LIIKEQEMKAKLEQIEESASEKLKICEIQ 364
K + E K KE + E L+++ + L+ + ++ + E+++ + E + + + +
Sbjct: 415 KSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAR 474
Query: 365 FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTE 424
E+ ++ + + QY +E+K+LK L+ +N++L N L EL+ E
Sbjct: 475 -EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQE 533
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKE-KNKFETSLSVTRDIVHVLTL 483
+ E+K +++ IN N+K + E+ +K+ +N ET + ++ +V
Sbjct: 534 TSDMTLELKNQQED-----IN-NNKKQE-----ERMLKQIENLQETETQLRNELEYV--- 579
Query: 484 RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAA 543
RE EL+Q D+V+ E N L N + E + +A LK K
Sbjct: 580 --RE---ELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKA----LKKKGT 630
Query: 544 LTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
+ + E V +E K+ + E+ + IED ++ E N L EEVE
Sbjct: 631 AESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKI--SEEN-----LLEEVE 683
Query: 604 KKRVLCE 610
K +V+ +
Sbjct: 684 KAKVIAD 690
Score = 51.6 bits (118), Expect = 1e-05
Identities = 94/418 (22%), Positives = 175/418 (41%), Gaps = 36/418 (8%)
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
E LK+ L E E L ++ S+L KE E K+++ + S +L+ E + +E + I+
Sbjct: 89 EGLKDSDL-ENSEGLSRVFSKLY-KEAE---KIKKWKVSTEAELRQKESKLQENRKIIEA 143
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q K IQ L+ +++ L+ +N DL +E N ++ + L E+ K
Sbjct: 144 ----QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
+ E E Y + LN +EK I + +R +H +L+E +++
Sbjct: 200 YEYEREETRQVYMD----LNNNIEKMITAHGELRVQAENSRLEMH---FKLKEDYEKIQH 252
Query: 495 LEDQVQMLTSAKE----VLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTR 550
LE + + + KE +L ++T +N + + +E ++ VN L+ K L E+ +
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK-VNQLEEKTKLQSENLK 311
Query: 551 -IMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLC 609
+E L + L++++ R + T K L ED+++ K I L EE E +
Sbjct: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKT----ICQLTEEKETQMEES 366
Query: 610 EMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENE 669
+ L + L E +R L +EL E E
Sbjct: 367 NKARAAHSFVVTEFETTVCSLEEL------LRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 670 ELTMTVAKQSSIIDKLKKDLEQSQ---YTPKSPSVLRKSLKVGKENMQTISPLRERNL 724
E+T + +++LKK L + + Y K + + LK ++ + + RE+ +
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
Score = 48.8 bits (111), Expect = 7e-05
Identities = 99/479 (20%), Positives = 196/479 (40%), Gaps = 52/479 (10%)
Query: 146 TKFRQSHNNIDFNEIDRKLSKL----RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRII 201
T ++ NID + +K++ L ++ N++CH + ++ +D E +
Sbjct: 53 TNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEG-LKDSDLENSEGLSRVFSKLYK 111
Query: 202 ELEK-KCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
E EK K + E +Q E S L+E + ++ K +QE NE + ++ ++ K
Sbjct: 112 EAEKIKKWKVSTEAELRQKE-SKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK 170
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
++ N + R + E ++ K K + E +T+ L N
Sbjct: 171 D----LIKENNATRHLCNLLKETCARSAEKTK-------KYEYEREETRQ--VYMDLNNN 217
Query: 321 MLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQE 380
+ E + H +L ++ + + ++ + EK++ E ++++ ++ S
Sbjct: 218 I-----EKMITAHGELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLL 272
Query: 381 KTIQYLEQEIKELKYTL-----------DLTNNQNSDLKQELNNLKNCKDELSTEKFNFI 429
I E ++K+L + L + T Q+ +LKQ + + EL K +
Sbjct: 273 IQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQ 332
Query: 430 EEIKTLKDELIEKTINYENEK-NKLNLAVEKAIKEKNKFET--SLSVTRDIVHVLTLR-- 484
+ T K +E+ + + +L E ++E NK S VT V +L
Sbjct: 333 RSVSTQK--ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 485 LRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAAL 544
LR LE+ EDQ+++LT + +EL NN E +E K+ +L K L
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKK----VLGEKETL 446
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVE 603
E+ + + + E L+ E+E L + E + D+E+ + ++ +EV+
Sbjct: 447 LYENKQFEK----IAEELKGTEQELIGLLQAREKE-VHDLEIQLTAITTSEQYYSKEVK 500
>BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein.
Length = 498
Score = 69.7 bits (163), Expect = 3e-11
Identities = 94/433 (21%), Positives = 196/433 (45%), Gaps = 36/433 (8%)
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
N + + E + + +D+ + ELEK AL+ ++ + + +L LE+ + + D
Sbjct: 32 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----DA 87
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEK--QAII 296
+ +L N L +R + E NE RR+ + +L +T+L++E+ +A+
Sbjct: 88 KLRLEVNMQALKGQFERDLQARD------EQNEEKRRQLQRQLHEYETELEDERKQRALA 141
Query: 297 SKCKVDQE-NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESAS 355
+ K E +LK +E + +K + EA++QL +L + ++ + +LE S
Sbjct: 142 AAAKKKLEGDLK-----DLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRD 195
Query: 356 EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK 415
E + + E++++S++ Q ++ + E+ K+ DL + +L +EL +
Sbjct: 196 EIFATAK-ENEKKAKSLEADLMQLQEDLAAAERARKQ----ADL---EKEELAEELASSL 247
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
+ ++ L EK I L++EL E+ N E +++ A ++A + N+ T S +
Sbjct: 248 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 307
Query: 476 ---DIVHVLTLRLRESDSELEQLEDQVQ-MLTSAKEVLENELTTYKNTLNNTVRECDEYK 531
L + +E S+L ++E V+ S LE ++ + + RE K
Sbjct: 308 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----K 363
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKES 591
+A LK K KE +E + E + ++ + +K +L E+ E +
Sbjct: 364 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRI 422
Query: 592 NSQIKFLREEVEK 604
N+ + L+ E+++
Sbjct: 423 NANRRKLQRELDE 435
Score = 45.6 bits (103), Expect = 6e-04
Identities = 80/433 (18%), Positives = 171/433 (39%), Gaps = 23/433 (5%)
Query: 290 EEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ 349
E++ +S + +E L+ K N+MLK + E L + E++ K ++
Sbjct: 6 EKETKALSLARALEEALEAKEELE---RTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKR 61
Query: 350 IEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
E+ E++K + E+ Q+ ++ + E +Q L+ + + L + QN + ++
Sbjct: 62 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKRR 118
Query: 410 ELNN-LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
+L L + EL E+ K +L + E + + E+AIK+ K +
Sbjct: 119 QLQRQLHEYETELEDERKQRALAAAA-KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 177
Query: 469 TSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECD 528
+ + + E + ++ E + + L + L+ +L + E +
Sbjct: 178 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 237
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQ----NVE------KEAYRELGTIKN 578
E E L + L + AL E R+ L E L+ N+E ++A ++ + N
Sbjct: 238 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 297
Query: 579 ELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
EL + +K +++ + R+ E + L EM +AQ +
Sbjct: 298 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 357
Query: 639 RLENENERYXXXXXXXXSLVVELSLL----RQENEELTMTVAKQSSIIDKLKKDLEQSQY 694
+ E + + E+ L R+ E+ K ++ + +LK+ LE+++
Sbjct: 358 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 417
Query: 695 TPKSPSVLRKSLK 707
+ + R+ L+
Sbjct: 418 ESQRINANRRKLQ 430
Score = 32.7 bits (71), Expect = 4.7
Identities = 37/202 (18%), Positives = 80/202 (39%), Gaps = 12/202 (5%)
Query: 6 KRFEPLVAQKNQKKTNVHKKLDSESTKINTKTSSSLCKSRSNTLNSIRPVDGXXXXXXXX 65
+R E +AQ ++ +++ S ++ T + + SN L + R
Sbjct: 258 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA--EQLSNELATERSTAQKNESARQQ 315
Query: 66 XXXXLKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELV-------QAQDVEIRNKDQ 118
K K ++ A S K T+ + KI +E V QA ++ KD+
Sbjct: 316 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 375
Query: 119 TICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEH 178
+ E Q+ED + Q +E ++ + +Q ++ E + + ++ N E
Sbjct: 376 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE--EAEEESQRINANRRKLQREL 433
Query: 179 NAVQGTDAEKVSAMINDMRSRI 200
+ ++ E + +N ++S++
Sbjct: 434 DEATESN-EAMGREVNALKSKL 454
>AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A
protein.
Length = 1016
Score = 69.7 bits (163), Expect = 3e-11
Identities = 110/485 (22%), Positives = 227/485 (46%), Gaps = 50/485 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF---RQSHNN--ID 156
+ +L+Q + ++ K + C+ K +D + ++ L+ ++E ++F Q N +D
Sbjct: 348 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 407
Query: 157 FNE----IDRKLSKLR--INNTNCHTEHNA-VQGTDAEKVSAMINDMR--SRIIELE-KK 206
+ ++++L K+R ++ EH V + +K+ + + I E + ++
Sbjct: 408 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 467
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQRLEMVKGHH 263
E L N + +K + S E++ ++ L +D+QE+ + E + E +Q L +V
Sbjct: 468 VEQLANHLKEKTDKCS---ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-LVSADT 523
Query: 264 ALALEANESIRR-EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
+E + E K EL +L+ +L E+ AI K K + NL+ + E L+N
Sbjct: 524 FQKVEDRKHFGAVEAKPEL-SLEVQLQAERDAIDRKEK-EITNLEEQLEQFREELEN--- 578
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH--CSQQE 380
K E ++QLH QL I+++E +L+++E ++ K+ + E+ +I+E S Q+
Sbjct: 579 --KNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLGLAIKESDAMSTQD 632
Query: 381 KTIQY--LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT---- 434
+ + + Q I+E + +D N Q + L+Q+L + +++ EK I +++T
Sbjct: 633 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIEC 690
Query: 435 -LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+ D+ K N E E +LN +EK +E S+ H L+ +L+
Sbjct: 691 LMSDQECVKR-NREEEIEQLNEVIEKLQQELANIGQKTSMN---AHSLSEEADSLKHQLD 746
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ + L E E+T KN L T + ++ + L ++ + + ++ K + I E
Sbjct: 747 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IPE 805
Query: 554 HNVTL 558
++V +
Sbjct: 806 NSVNV 810
Score = 62.5 bits (145), Expect = 5e-09
Identities = 83/418 (19%), Positives = 188/418 (44%), Gaps = 27/418 (6%)
Query: 198 SRIIELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN-ELTLAETQQ 254
+R+ ELE + + + + E+ +Q E E V L ++ ++ + E+ +
Sbjct: 314 NRLQELEAEQQQIQEERELLSRQKEAMKAEAG-PVEQQLLQETEKLMKEKLEVQCQAEKV 372
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLD--EEKQAI---ISKCK--VDQENLK 307
R ++ K AL ++ E + R ++E E +D ++ QA+ + K + +D++ +
Sbjct: 373 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 432
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H + + Q L+++ + + + I E + + ++EQ+ EK C
Sbjct: 433 REHERDVFQQEIQKLEQQLKVVPRFQP---ISEHQTR-EVEQLANHLKEKTDKCSELLLS 488
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q +Q ++ + I+ LE ++EL+ L ++ +D Q++ + K+ + + +
Sbjct: 489 KEQ-LQRDIQERNEEIEKLEFRVRELEQALLVS----ADTFQKVEDRKHFGAVEAKPELS 543
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLR 486
+++ +D + K N + +L E+ ++ KN+ L + +I T RL+
Sbjct: 544 LEVQLQAERDAIDRKEKEITNLEEQLEQFREE-LENKNEEVQQLHMQLEIQKKESTTRLQ 602
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
E + E + +D ++ L A + + T ++ L + + KE ++ L + +
Sbjct: 603 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 662
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ +I N + E + E R+L T L+ D E +K+ +I+ L E +EK
Sbjct: 663 QQLKITTDNKVIEE-----KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 715
Score = 54.4 bits (125), Expect = 1e-06
Identities = 103/504 (20%), Positives = 219/504 (43%), Gaps = 48/504 (9%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+ I E + Q+E K + Q E+++E FRQ + + +L + R++ + E
Sbjct: 216 EAISETSSQLEHAK--VTQT-ELMRE---SFRQKQEATESLKCQEELRE-RLHEESRARE 268
Query: 178 HNAVQGTDAEKVSAMINDMRSRII-ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
AV+ + AE V D ++ ++++K + +D + + L+E+ ++ +
Sbjct: 269 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL----EAEQQ 324
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
+QE+ L+ + + E L E + ++ + +++ +A K + D +KQ
Sbjct: 325 QIQEE--RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 382
Query: 297 SKCKVDQE-----NLKTKHNASIESLK--NQMLKEKCEALEQ-LHSQLIIKEQEMKAKLE 348
+ V+++ L+ + N + L+ NQ L+++ E + + L Q I +E E +
Sbjct: 383 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQ 442
Query: 349 QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+I++ ++LK+ R Q I EH +++ +EQ LK D + +
Sbjct: 443 EIQK-LEQQLKVVP-----RFQPISEHQTRE------VEQLANHLKEKTDKCSELLLSKE 490
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
Q +++ +E+ EK F ++ L+ L+ ++ +++ + +A K + E
Sbjct: 491 QLQRDIQERNEEI--EKLEF--RVRELEQALLVSADTFQKVEDRKHFGAVEA-KPELSLE 545
Query: 469 TSLSVTRDIV-----HVLTL--RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
L RD + + L +L + ELE ++VQ L E+ + E TT L
Sbjct: 546 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE 605
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT-IKNEL 580
+ + E L +K A++ + ++ I + VE + E T ++ +L
Sbjct: 606 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 665
Query: 581 -IEDVELLKKESNSQIKFLREEVE 603
I + +E N I+ L ++E
Sbjct: 666 KITTDNKVIEEKNELIRDLETQIE 689
>AL832009-1|CAD89912.1| 1177|Homo sapiens hypothetical protein
protein.
Length = 1177
Score = 69.7 bits (163), Expect = 3e-11
Identities = 93/409 (22%), Positives = 184/409 (44%), Gaps = 28/409 (6%)
Query: 202 ELEKKCEALDNE-VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLA-ETQQRLEMV 259
E E+ + L+ E Y + E + + + +RD L K L S L L E Q +E +
Sbjct: 207 ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVK-----LKSFALMLVDERQMHIEQL 261
Query: 260 KGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKN 319
+ + +R E + +L+A+ +K E++Q ++ K +VD E H AS S ++
Sbjct: 262 GLQSQKVQDLTQKLREEEE-KLKAITSKSKEDRQKLL-KLEVDFE-----HKASRFSQEH 314
Query: 320 QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQ 379
+ + K E + QL +K + ++E++EE K EE Q +++ ++
Sbjct: 315 EEMNAKLANQESHNRQLRLKLVGLTQRIEELEEINKNLQKA-----EEELQELRDKIAKG 369
Query: 380 EKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDEL 439
E L E++ L+ + ++ ++ + + + + +L E+ + K L+ E
Sbjct: 370 ECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHS----KELRLE- 424
Query: 440 IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV 499
+EK +E KL A K+ E + +L +++ L L S +++LE
Sbjct: 425 VEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSE 484
Query: 500 QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLI 559
L A+ L+++LT K+ TV DE K + I + + + + ++
Sbjct: 485 SRLEKAELSLKDDLTKLKSF---TVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVM 541
Query: 560 ESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ + + +E+ ++L +K+E+ E V L +E + I L+ E EK L
Sbjct: 542 DVTEKLIEES-KKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSEL 589
Score = 64.1 bits (149), Expect = 2e-09
Identities = 76/431 (17%), Positives = 185/431 (42%), Gaps = 13/431 (3%)
Query: 94 CPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHN 153
C + ++ + E ++ + +E+ KD+ I + Q + + ++ + + KEL + +
Sbjct: 371 CGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQK 430
Query: 154 NI-DFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDN 212
+ + +++ SK + T H + + ++ + ++SR+ ELE L+
Sbjct: 431 RMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE-LEVVKSRVKELECSESRLEK 489
Query: 213 EVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+ +L+ L+ + K++ EK+ E + + ++ +G ++ E
Sbjct: 490 AELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGK---VMDVTEK 546
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIE-SLKNQMLKEKCEALEQ 331
+ E K +L LK++++E+ + + LK++ S E S +LK++ + +E+
Sbjct: 547 LIEESK-KLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEE 605
Query: 332 LHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIK 391
+ ++ ++L E++ K+K ++ E + +Q+ E + E E
Sbjct: 606 VEREITRGRSRKGSELTCPEDN---KIKELTLEIERLKKRLQQ-LEVVEGDLMKTEDEYD 661
Query: 392 ELKYTLDLTNNQNSDLKQELNNLKN-CKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+L+ ++ + L Q+L +K+ + EK + + L+ + + K
Sbjct: 662 QLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 721
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
++ EK + NK E LS + VL R E +++ + + +V LT E+ +
Sbjct: 722 AEVQALKEKIHELMNK-EDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK 780
Query: 511 NELTTYKNTLN 521
+ ++N
Sbjct: 781 RYSRALRPSVN 791
Score = 60.5 bits (140), Expect = 2e-08
Identities = 100/504 (19%), Positives = 224/504 (44%), Gaps = 43/504 (8%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N+ +Y + +D+ N + Q +E LK+L + +++ E ++L+KLR
Sbjct: 182 ELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQ-EKAYQARKEKENAKRLNKLRDEL 240
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVR 231
+ + M+ D R IE + +V D +L EE +
Sbjct: 241 VKL------------KSFALMLVDERQMHIE---QLGLQSQKVQDLTQKLREEEEKLKAI 285
Query: 232 DSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEE 291
S K+ ++KL E+ R L ES R+ +++L L +++E
Sbjct: 286 TSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEEL 345
Query: 292 KQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
++ I+K NL+ K ++ L++++ K +C +S L+ + + ++ ++ ++E
Sbjct: 346 EE--INK------NLQ-KAEEELQELRDKIAKGECG-----NSSLMAEVENLRKRVLEME 391
Query: 352 ESASEKLKICEIQFEERSQSIQE---HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
E++ E Q E + +QE H + ++ L++ + EL+ + + S+
Sbjct: 392 -GKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECT 450
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
Q NL+ K+ L+ + N +E +K+ EL E + E+ K L+++ + + F
Sbjct: 451 QLHLNLEKEKN-LTKDLLNELEVVKSRVKEL-ECS---ESRLEKAELSLKDDLTKLKSFT 505
Query: 469 TSLSVTR-DIVHVLTLRLRESDSELEQLE-DQVQMLTSAKEVLEN--ELTTYKNTLNNTV 524
L R +++ + R+ D + + +Q +++ ++++E +L K+ + V
Sbjct: 506 VMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKV 565
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
++ L+ LKS+ + E + ++ ++ ++ VE+E R +EL
Sbjct: 566 YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE 625
Query: 585 ELLKKESNSQIKFLREEVEKKRVL 608
+ KE +I+ L++ +++ V+
Sbjct: 626 DNKIKELTLEIERLKKRLQQLEVV 649
>AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein.
Length = 2058
Score = 69.7 bits (163), Expect = 3e-11
Identities = 110/485 (22%), Positives = 227/485 (46%), Gaps = 50/485 (10%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF---RQSHNN--ID 156
+ +L+Q + ++ K + C+ K +D + ++ L+ ++E ++F Q N +D
Sbjct: 201 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 260
Query: 157 FNE----IDRKLSKLR--INNTNCHTEHNA-VQGTDAEKVSAMINDMR--SRIIELE-KK 206
+ ++++L K+R ++ EH V + +K+ + + I E + ++
Sbjct: 261 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 320
Query: 207 CEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK---LTSNELTLAETQQRLEMVKGHH 263
E L N + +K + S E++ ++ L +D+QE+ + E + E +Q L +V
Sbjct: 321 VEQLANHLKEKTDKCS---ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-LVSADT 376
Query: 264 ALALEANESIRR-EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQML 322
+E + E K EL +L+ +L E+ AI K K + NL+ + E L+N
Sbjct: 377 FQKVEDRKHFGAVEAKPEL-SLEVQLQAERDAIDRKEK-EITNLEEQLEQFREELEN--- 431
Query: 323 KEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH--CSQQE 380
K E ++QLH QL I+++E +L+++E ++ K+ + E+ +I+E S Q+
Sbjct: 432 --KNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLGLAIKESDAMSTQD 485
Query: 381 KTIQY--LEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT---- 434
+ + + Q I+E + +D N Q + L+Q+L + +++ EK I +++T
Sbjct: 486 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIEC 543
Query: 435 -LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+ D+ K N E E +LN +EK +E S+ H L+ +L+
Sbjct: 544 LMSDQECVKR-NREEEIEQLNEVIEKLQQELANIGQKTSMN---AHSLSEEADSLKHQLD 599
Query: 494 QLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
+ + L E E+T KN L T + ++ + L ++ + + ++ K + I E
Sbjct: 600 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS-IPE 658
Query: 554 HNVTL 558
++V +
Sbjct: 659 NSVNV 663
Score = 62.5 bits (145), Expect = 5e-09
Identities = 83/418 (19%), Positives = 188/418 (44%), Gaps = 27/418 (6%)
Query: 198 SRIIELEKKCEAL--DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN-ELTLAETQQ 254
+R+ ELE + + + + E+ +Q E E V L ++ ++ + E+ +
Sbjct: 167 NRLQELEAEQQQIQEERELLSRQKEAMKAEAG-PVEQQLLQETEKLMKEKLEVQCQAEKV 225
Query: 255 RLEMVKGHHALALEANESIRREYKIELEALKTKLD--EEKQAI---ISKCK--VDQENLK 307
R ++ K AL ++ E + R ++E E +D ++ QA+ + K + +D++ +
Sbjct: 226 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 285
Query: 308 TKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE 367
+H + + Q L+++ + + + I E + + ++EQ+ EK C
Sbjct: 286 REHERDVFQQEIQKLEQQLKVVPRFQP---ISEHQTR-EVEQLANHLKEKTDKCSELLLS 341
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ Q +Q ++ + I+ LE ++EL+ L ++ +D Q++ + K+ + + +
Sbjct: 342 KEQ-LQRDIQERNEEIEKLEFRVRELEQALLVS----ADTFQKVEDRKHFGAVEAKPELS 396
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHV-LTLRLR 486
+++ +D + K N + +L E+ ++ KN+ L + +I T RL+
Sbjct: 397 LEVQLQAERDAIDRKEKEITNLEEQLEQFREE-LENKNEEVQQLHMQLEIQKKESTTRLQ 455
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
E + E + +D ++ L A + + T ++ L + + KE ++ L + +
Sbjct: 456 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 515
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ +I N + E + E R+L T L+ D E +K+ +I+ L E +EK
Sbjct: 516 QQLKITTDNKVIEE-----KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 568
Score = 54.8 bits (126), Expect = 1e-06
Identities = 92/405 (22%), Positives = 184/405 (45%), Gaps = 42/405 (10%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIE 280
+SSL+++IT + L ++ E S++ + + R E++ + LE + ++ E
Sbjct: 1201 ISSLKDLIT-KMQLQREA-EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTE 1258
Query: 281 LEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL---- 336
L AL T + +++ + + ++ A++E L+ + ++ LH+Q+
Sbjct: 1259 LTALGTT---DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 1315
Query: 337 --IIKEQEM-KAKLEQIEESASEKL-KICEIQFE-----ERSQSIQEHCSQQEKTIQYLE 387
+ +EQE K E +E + +K ++ E+Q E +R+ +QE S ++ + L+
Sbjct: 1316 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 1375
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
E+ + K L+ T LK + +LK EL E F + KT + L+ T+ E
Sbjct: 1376 SELAQTKLELETT------LKAQHKHLK----EL--EAFRLEVKDKTDEVHLLNDTLASE 1423
Query: 448 NEKNK-LNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ----LEDQVQML 502
+K++ L A+E KEK K S ++ + L L Q LE Q Q+L
Sbjct: 1424 QKKSRELQWALE---KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 1480
Query: 503 TSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESL 562
+++ +E++ Y L+ E E V +L+S+ +E + ++ L L
Sbjct: 1481 NESQQKIESQRMLYDAQLS---EEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQL 1536
Query: 563 QNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
Q+ + +L+++++ +E +S+I L E EK ++
Sbjct: 1537 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 1581
Score = 54.4 bits (125), Expect = 1e-06
Identities = 103/504 (20%), Positives = 219/504 (43%), Gaps = 48/504 (9%)
Query: 118 QTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTE 177
+ I E + Q+E K + Q E+++E FRQ + + +L + R++ + E
Sbjct: 69 EAISETSSQLEHAK--VTQT-ELMRE---SFRQKQEATESLKCQEELRE-RLHEESRARE 121
Query: 178 HNAVQGTDAEKVSAMINDMRSRII-ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCK 236
AV+ + AE V D ++ ++++K + +D + + L+E+ ++ +
Sbjct: 122 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL----EAEQQ 177
Query: 237 DLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAII 296
+QE+ L+ + + E L E + ++ + +++ +A K + D +KQ
Sbjct: 178 QIQEE--RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 235
Query: 297 SKCKVDQE-----NLKTKHNASIESLK--NQMLKEKCEALEQ-LHSQLIIKEQEMKAKLE 348
+ V+++ L+ + N + L+ NQ L+++ E + + L Q I +E E +
Sbjct: 236 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQ 295
Query: 349 QIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLK 408
+I++ ++LK+ R Q I EH +++ +EQ LK D + +
Sbjct: 296 EIQK-LEQQLKVVP-----RFQPISEHQTRE------VEQLANHLKEKTDKCSELLLSKE 343
Query: 409 QELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFE 468
Q +++ +E+ EK F ++ L+ L+ ++ +++ + +A K + E
Sbjct: 344 QLQRDIQERNEEI--EKLEF--RVRELEQALLVSADTFQKVEDRKHFGAVEA-KPELSLE 398
Query: 469 TSLSVTRDIV-----HVLTL--RLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLN 521
L RD + + L +L + ELE ++VQ L E+ + E TT L
Sbjct: 399 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE 458
Query: 522 NTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT-IKNEL 580
+ + E L +K A++ + ++ I + VE + E T ++ +L
Sbjct: 459 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 518
Query: 581 -IEDVELLKKESNSQIKFLREEVE 603
I + +E N I+ L ++E
Sbjct: 519 KITTDNKVIEEKNELIRDLETQIE 542
Score = 54.0 bits (124), Expect = 2e-06
Identities = 101/516 (19%), Positives = 213/516 (41%), Gaps = 47/516 (9%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
D L DV I K +Q+E E+ ++ +LKE N N++ +
Sbjct: 592 DSLKHQLDVVIAEK----LALEQQVETANEEMTFMKNVLKE---------TNFKMNQLTQ 638
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS-RIIELEKKCEALDNEVYDKQMEL 221
+L L+ + + + + + + D ++ E ++L+N+ Y K E
Sbjct: 639 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 698
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEA-NESIRREYKIE 280
+ +I + L + L+ +++ +L L + ++++ ++ E + I KI
Sbjct: 699 NGKGSIINLETRLLQ-LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 757
Query: 281 LEALKTKLDEEKQ--AIISKCKVDQENLKTKHNASIESLKN-QMLKEKCEALEQLHSQLI 337
E + L + Q A+ K Q+N +++N L+E + L S L
Sbjct: 758 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALT 815
Query: 338 IKEQEMKAKLEQIEESA---SEKLKICEIQFEERSQSIQE--------HCSQQEKTIQYL 386
++ E+++++ ++ S E+++I E E+ + + E Q+EK +
Sbjct: 816 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 875
Query: 387 EQEIKELKYTLDLTN-NQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTIN 445
Q+++ LK T +L + N+ S EL L+ E ++ E+ + L++EL+ K N
Sbjct: 876 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 935
Query: 446 YENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
+ + L+ + + K K S+ D V +S+ + + + + S
Sbjct: 936 MTSLQKDLSQVRDHLAEAKEKL--SILEKEDETEV-------QESKKACMFEPLPIKLSK 986
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
+ + T ++ N T + K A + I ++E T I+ IE +Q +
Sbjct: 987 SIASQTDGTLKISSSNQTPQIL--VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 1044
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREE 601
E+ +++ I + E LK+E ++ L+EE
Sbjct: 1045 HAA---EILDMESRHISETETLKREHYVAVQLLKEE 1077
Score = 37.1 bits (82), Expect = 0.22
Identities = 64/339 (18%), Positives = 146/339 (43%), Gaps = 31/339 (9%)
Query: 102 QDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDF 157
Q ++++ Q VE+ + E +Q+ K +A+L+ L EL T + H ++
Sbjct: 1340 QSQMLEMQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 1398
Query: 158 NEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKK----CEALDNE 213
E R K + + + + A + + ++ + ++++ E++ E L
Sbjct: 1399 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 1458
Query: 214 VYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT----LAETQQR-LEM---VKGHHAL 265
+ ++ L ++ + L + Q+K+ S + L+E Q R LE+ ++
Sbjct: 1459 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 1518
Query: 266 ALEANESIRREYKIELEALKTK-LDEEKQAIISK--CKVDQENLKTKHNASIESLKNQML 322
E + ++ RE ++ + + + + + S+ K Q+ L+ KH+ +E L N+
Sbjct: 1519 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELL-NETE 1577
Query: 323 KEKCEALE---------QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQ 373
K K ++L+ Q+H + + EQE + ++ K++ + Q EE+ Q +
Sbjct: 1578 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 1637
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELN 412
+ + + +Q + QE ++ + + L Q LN
Sbjct: 1638 K-LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN 1675
Score = 35.5 bits (78), Expect = 0.67
Identities = 78/363 (21%), Positives = 155/363 (42%), Gaps = 46/363 (12%)
Query: 96 KNKILPQDELVQAQDVEIRNKDQTICEYNKQ----IEDYKNEIAQLQEILKELATKFRQS 151
+ ++L + V A+D+E+ + I + +Q E + +I LQ+I++E S
Sbjct: 708 ETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 767
Query: 152 HNNIDFNEIDRKLSKLRINNT-NCHTEHNAVQGTDA---EKVSAMINDMRSRIIELEKKC 207
I + + N T + E +Q + +++ + I+ + RI ELE +
Sbjct: 768 Q--IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQV 825
Query: 208 EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALAL 267
+ + ++ ++ E+ + ++ +LQ+ L N E +QR
Sbjct: 826 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN-----EKKQR------------ 868
Query: 268 EANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCE 327
E ++ ++E LKT + S + E L+ + A+ L + KEK E
Sbjct: 869 ---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAE 923
Query: 328 ALEQLHSQLIIKEQEM---KAKLEQIEE---SASEKLKICEIQFEERSQSIQEHCSQQEK 381
L++ +L++KE M + L Q+ + A EKL I E + E Q ++ C +
Sbjct: 924 KLQE---ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 980
Query: 382 TIQYLEQEIKELKYTLDL-TNNQNSDLKQELNNLK-NCKDELSTEKFNFIEEIKTLKDEL 439
I+ + + TL + ++NQ + + ++ N + E S+E+ + EI + E
Sbjct: 981 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE---VTEIISQFTEK 1037
Query: 440 IEK 442
IEK
Sbjct: 1038 IEK 1040
>M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy chain
protein.
Length = 1937
Score = 68.9 bits (161), Expect = 6e-11
Identities = 123/625 (19%), Positives = 256/625 (40%), Gaps = 52/625 (8%)
Query: 86 SSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELA 145
S +KK + + + ++ A + +++N + + ++ I E LQE ++
Sbjct: 951 SELKKDIDDLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL 1010
Query: 146 TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIN-DMR---SRII 201
+ + ++ + + ++++ E D E+ + D++ +
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
++E + LD ++ K+ E+S+L I ++ LQ+K+ + + E + +E +
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERA 1130
Query: 262 HHALALEANESIRREYKIELEAL---------KTKLDEEKQAIISKCKVDQENLKTKHNA 312
A A + + RE + E L + +L+++++A K + D E +H A
Sbjct: 1131 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEA 1190
Query: 313 SIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSI 372
+ +L+ K+ +++ +L Q I Q +K KLE+ E+S +LK+ +++I
Sbjct: 1191 MVAALR----KKHADSMAELGEQ-IDNLQRVKQKLEK-EKS---ELKMETDDLSSNAEAI 1241
Query: 373 QEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEI 432
+ EK + LE ++ LK + +DL + L+ E S + ++E
Sbjct: 1242 SKAKGHLEKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ----LDEQ 1297
Query: 433 KTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
L +L + +L +E+ K KN +L +R H L + + E
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSR---HDCDLLREQYEEEQ 1354
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
E + + L+ A + T Y+ E +E K+ L L+ +EH +
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE----AEEHVEAV 1410
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFL-REEVEKKRVLCEM 611
++EK R ++NE +ED+ L + SN+ L +++ +VL E
Sbjct: 1411 N------AKCASLEKTKQR----LQNE-VEDLMLDVERSNAACAALDKKQRNFDKVLSEW 1459
Query: 612 XXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
S+ + +L +++N Y +L L+QE +L
Sbjct: 1460 -KQKYEETQAELEASQKESRSLSTELFKVKNV---YEESLDQLETLRRAHKNLQQEISDL 1515
Query: 672 TMTVA---KQSSIIDKLKKDLEQSQ 693
T +A KQ ++K+KK +EQ +
Sbjct: 1516 TEQIAEGGKQIHELEKIKKQVEQEK 1540
Score = 67.3 bits (157), Expect = 2e-10
Identities = 105/511 (20%), Positives = 219/511 (42%), Gaps = 43/511 (8%)
Query: 203 LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLE-MVKG 261
++++ + +E+ + + LEE + DLQ ++ S +LA+ ++R E ++K
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 262 HHALALEANESIRR-----EYKIELEALKTKLDEEKQAI---ISKCKVDQENLKTKHNAS 313
L + E R E EL A K KL++E + I ++ ++ + +A+
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKQKHAT 974
Query: 314 IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQ-IEESASEKLKI-----CEIQFEE 367
+KN L E+ L++ ++L +++ ++ +Q +++ +E+ K+ + + E+
Sbjct: 975 ENKVKN--LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQ 1032
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ ++ Q++K LE+ ++L+ L L D++ N+ + ++L ++F
Sbjct: 1033 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME---NDKQQLDEKLEKKEFE 1089
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRE 487
I ++DE + I + + +L +E+ +E S + L+ L E
Sbjct: 1090 ISNLISKIEDEQAVE-IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
LE+ TSA+ L + L + E EA+V AAL K+
Sbjct: 1149 ISERLEEAGG----ATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV------AALRKK 1198
Query: 548 HTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRV 607
H M I++LQ V+++ +E K+EL + + L + + I + +EK
Sbjct: 1199 HADSMAELGEQIDNLQRVKQKLEKE----KSELKMETDDLSSNAEA-ISKAKGHLEK--- 1250
Query: 608 LCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQE 667
+C + L+ A +RL+ E Y +LV +LS +Q
Sbjct: 1251 MCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEQDALVSQLSRSKQA 1310
Query: 668 N----EELTMTVAKQSSIIDKLKKDLEQSQY 694
+ EEL + +++ + L L+ S++
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRH 1341
Score = 66.1 bits (154), Expect = 4e-10
Identities = 82/423 (19%), Positives = 183/423 (43%), Gaps = 21/423 (4%)
Query: 276 EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA-----LE 330
E + E+ +K + + K + +K + ++ L+ K ++ + L+ + EA E
Sbjct: 847 ETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEI 390
+ QLI + +++AK++++ E A E+ +I + + + +++ CS+ +K I LE +
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEI-NAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 391 KELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEK 450
+++ T N+ +L +E+ L +LS EK E + D+L + E++
Sbjct: 965 AKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE----EDKV 1020
Query: 451 NKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLE 510
N L A K ++ + E SL + + L R+ + +L+ ++ + + K+ L+
Sbjct: 1021 NILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLD 1080
Query: 511 NELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAY 570
+L + ++N + + ++ + + + K KE +E IE+ + +A
Sbjct: 1081 EKLEKKEFEISNLISKIEDEQAVEIQLQKK----IKELQARIEELGEEIEAERASRAKAE 1136
Query: 571 RELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLL 630
++ + EL E E L++ + + E+ KKR E ++
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGA--TSAQVELNKKRE-AEFQKLRRDLEEATLQHEAMVA 1193
Query: 631 AQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM---TVAKQSSIIDKLKK 687
A + E+ L E S L+ E ++L+ ++K ++K+ +
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGHLEKMCR 1253
Query: 688 DLE 690
LE
Sbjct: 1254 SLE 1256
Score = 50.8 bits (116), Expect = 2e-05
Identities = 102/526 (19%), Positives = 213/526 (40%), Gaps = 45/526 (8%)
Query: 103 DELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDR 162
+E V+A + + + ++T ++ED ++ + L K R D+
Sbjct: 1404 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN---------FDK 1454
Query: 163 KLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELS 222
LS+ + E A Q ++ +S + +++ E + E L + Q E+S
Sbjct: 1455 VLSEWKQKYEETQAELEASQ-KESRSLSTELFKVKNVYEESLDQLETLRRAHKNLQQEIS 1513
Query: 223 SLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELE 282
L E I +L++ E E Q LE + +LE E ++EL
Sbjct: 1514 DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA----SLEHEEGKILRIQLELN 1569
Query: 283 ALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQM---LKEKCEALEQLHSQLIIK 339
+K+++D + I++ + + LK H +E++++ + ++ + +AL ++ ++
Sbjct: 1570 QVKSEVDRK----IAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL-RVKKKMEGD 1624
Query: 340 EQEMKAKLEQIEESASEKLK--------ICEIQFE-----ERSQSIQEHCSQQEKTIQYL 386
EM+ +L A+E L+ + E Q + ++E + E+ L
Sbjct: 1625 LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLL 1684
Query: 387 EQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINY 446
+ EI+EL TL+ T +QEL + L T+ + I K L++++ +
Sbjct: 1685 QAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV 1744
Query: 447 E---NEKNKLNLAVEKAIKEKNKFETSLSVTRDI-VHVLTLR--LRESDSELEQLEDQVQ 500
E E +KAI + L +D H+ ++ L ++ +L+ D+ +
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804
Query: 501 MLT--SAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTL 558
L K+ ++ +L L V + V L+ KE T E +
Sbjct: 1805 QLALKGGKKQIQ-KLEARVRELEGEVENEQKRNAEAVKGLRKHDRRVKELTYQTEEDRKN 1863
Query: 559 IESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEK 604
+ LQ++ + ++ + K + E+ E + S+ + L+ E+E+
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQ-AEEAEEQSNANLSKFRKLQHELEE 1908
>AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.19 protein.
Length = 820
Score = 68.9 bits (161), Expect = 6e-11
Identities = 119/566 (21%), Positives = 254/566 (44%), Gaps = 60/566 (10%)
Query: 88 IKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ-EILKELA- 145
+KK + KI +EL++A+ +++ NK++T+ + ++I+ K EI +Q E ++L+
Sbjct: 262 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 321
Query: 146 -TKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA----EKVSAMINDMRSRI 200
+K ++ N + E K + + D E + A + ++
Sbjct: 322 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 381
Query: 201 IE---LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKD----LQEKLTSNELTLAETQ 253
++ + E L+ + +K+ EL LE ++ R+S LQ+ N+L ++ +
Sbjct: 382 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 441
Query: 254 QRLEMVKGHHALALEANESIRR---EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
Q L+ A + +E + + E + E+ L +LD K A+ + K + + L+ K+
Sbjct: 442 Q-LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND-LREKN 499
Query: 311 NASIESLKN--QMLKEKC-EALEQLHSQLIIKEQEMKAKLEQI--EESASEKLKICE--I 363
++E+L + +ML++K + ++ Q+ E E K L+++ + S L E
Sbjct: 500 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 559
Query: 364 QFEERSQSIQEHCSQQEKTIQYLEQEIKEL------------KY------TLDLTNNQNS 405
FE++++ S E+ ++ LE ++KE KY T +
Sbjct: 560 GFEKKAKECMAGTSGSEE-VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 618
Query: 406 DLKQELNNLKNCKDE----LSTEKFNFI---EEIKTLKDELIEKTI-NYENEKNKLNLAV 457
++QE N K DE + + +F +E++ L+ E K I N E+ L + +
Sbjct: 619 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE--NKDIENLRREREHLEMEL 676
Query: 458 EKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYK 517
EKA E++ + T + +D++ L +L +S SE + +++ +L + +L T +
Sbjct: 677 EKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQ 736
Query: 518 NTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIK 577
N + + +++L +++SK T ++E N + ++ EKE +
Sbjct: 737 NERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIE-NSDVSPETESSEKET---MSVSL 791
Query: 578 NELIEDVELLKKESNSQIKFLREEVE 603
N+ + ++ L + N Q+ +E +
Sbjct: 792 NQTVTQLQQLLQAVNQQLTKEKEHYQ 817
Score = 62.9 bits (146), Expect = 4e-09
Identities = 132/627 (21%), Positives = 258/627 (41%), Gaps = 54/627 (8%)
Query: 104 ELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRK 163
+L++++ + ++ + +E + AQ+Q+ ++A + S + +++ +
Sbjct: 15 QLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAE 74
Query: 164 LSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSS 223
K +I T + T E+ I +M + +K +AL NE EL
Sbjct: 75 KDK-QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 133
Query: 224 LEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEA 283
+++ + V+D + L+E+L E ++E K + + N+++ K E++
Sbjct: 134 MQQSVYVKDDKIRLLEEQLQH------EISNKMEEFK----ILNDQNKAL----KSEVQK 179
Query: 284 LKTKLDEE--KQAI--ISKC-KVDQENLKTKHNASIESLKNQMLK-EKCEALEQLHSQLI 337
L+T + E+ K + + KC + E LKT L K E+ A+ +S L
Sbjct: 180 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 239
Query: 338 IKEQEMKAKL-EQIE-ESASEKLKICEIQFEERSQSIQE-------HCSQQEKTIQYLEQ 388
+ Q++KAK +Q+ S E+LK + + + +S++E + +EKT+Q L+Q
Sbjct: 240 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 299
Query: 389 EIKELKY---TLDLTNNQNSDLK---QELNN-LKNCKDELSTEKFNFIEEIKTLKDE-LI 440
EIK LK + L Q + QEL N LK +++++T K E+ K L +
Sbjct: 300 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 359
Query: 441 EKTINYENEKNKL--------NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSEL 492
+ + ENE K NL + + + E L + + L L+E +S+L
Sbjct: 360 LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL 419
Query: 493 EQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL---KSKAALTKEHT 549
+Q + ++ ++++ K ++E L I K + L E
Sbjct: 420 SSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 479
Query: 550 RI---MEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+ +EH L+ EA L + + L + V KE Q++ + E+E K
Sbjct: 480 SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV--ELEAKE 537
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQ 666
VL ++ + A + + +E +LL+
Sbjct: 538 VLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQL 597
Query: 667 ENEELTMTVAKQSSIIDKLKKDLEQSQ 693
E E+ +A+ I+ KL++ +EQ +
Sbjct: 598 ECEKYKSVLAETEGILQKLQRSVEQEE 624
Score = 50.4 bits (115), Expect = 2e-05
Identities = 55/277 (19%), Positives = 123/277 (44%), Gaps = 14/277 (5%)
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
++ +Q+++ +L Q+ ES +++ E + + Q I E + IQ +I
Sbjct: 3 LVSKQQLEQRLMQLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 61
Query: 397 LDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLN-L 455
L + + ++ +K +D L++E+ + + LKD + + E KL L
Sbjct: 62 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQAL 120
Query: 456 AVEKAIK--EKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
A E+A E K + S+ V D + +L +L+ E+ ++ ++L + L++E+
Sbjct: 121 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEV 177
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYREL 573
+ ++ + + E + ++ K K ++E + + + ++E +
Sbjct: 178 QKLQTLVSEQPNK--DVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT----KEEELNAI 231
Query: 574 GTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCE 610
T + L ++V+ LK + N Q+ F E K+V+ E
Sbjct: 232 RTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 268
>AK025632-1|BAB15196.1| 720|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21979 fis, clone HEP06065. ).
Length = 720
Score = 68.9 bits (161), Expect = 6e-11
Identities = 136/677 (20%), Positives = 282/677 (41%), Gaps = 47/677 (6%)
Query: 77 AFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQ 136
A +++ + I+ TL K K + + + + R KD+ + E K+++DY++ +
Sbjct: 33 ASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYG 92
Query: 137 LQEILKELAT-KFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIND 195
L++ + E+ K + + + + ++++KL + ++ E+ A++ + MI+
Sbjct: 93 LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL 152
Query: 196 MRSRIIE-LEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK--------LTSNE 246
R + L+++ +N++ K++E S EE + ++ + + QE+ LT+ +
Sbjct: 153 TEFRNSKHLKQQQYRAENQILLKEIE-SLEEERLDLKKKIRQMAQERGKRSATSGLTTED 211
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENL 306
L L E + + + L + K E + + +++E+ S+ + +
Sbjct: 212 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLS-RELIEKERDLERSRTVIAKFQN 270
Query: 307 KTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE-KLKICEIQF 365
K K + +KE +A++++ +K E + +E + + K E F
Sbjct: 271 KLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIF 330
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL-STE 424
+ S ++ Q + L QE++E + + Q + ++++L+ L +E
Sbjct: 331 -DASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSE 389
Query: 425 KFNFIEEIKTLKDELIEKTINYENEKNK--LNLAVEKAIKEK--NKFETSL-SVTRD--- 476
N + + L D + + + N +N+ ++L E KEK E SL R
Sbjct: 390 GSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAV 449
Query: 477 IVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENE-------LTTYKNTLNNTVRECDE 529
I H +L +E SE E + + + + K LE++ + Y N LN + DE
Sbjct: 450 IRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDE 509
Query: 530 YKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR---ELGTIKNELIEDVEL 586
K+ L + L ++ TL+E + + KE + EL +++ E+ E +
Sbjct: 510 MKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGC 569
Query: 587 L---KKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVL-----LAQAAADLS 638
L K+ + +I L++ V+ L E+ +L L Q ++L
Sbjct: 570 LQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLE 629
Query: 639 RLENEN----ERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQY 694
LE EN E+ +L + Q E+ T + +SS +DK KK + S
Sbjct: 630 HLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-KLGNESS-MDKAKKSITNSDI 687
Query: 695 TPKSPSVLRKSLKVGKE 711
S +K K K+
Sbjct: 688 VSISKKKKKKKKKKKKK 704
>AF212162-1|AAF23015.2| 2096|Homo sapiens ninein protein.
Length = 2096
Score = 68.9 bits (161), Expect = 6e-11
Identities = 131/642 (20%), Positives = 257/642 (40%), Gaps = 39/642 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
K+ + KN++ + E + Q + R + + E K E+Y + L LKE +
Sbjct: 433 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS--LKENSRLE 490
Query: 149 RQSHNNID-FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ N + E + +KL+ N N E + + + E E++C
Sbjct: 491 NELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 550
Query: 208 EALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA-L 265
L ++V + Q EL + +R L E++ +N + E + L + + +
Sbjct: 551 RVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI-EPEHGLGSEECNPLNM 609
Query: 266 ALEAN---ESIRREYKIELEALKTKLDE-----EKQA--IISKCKVDQENLKTKHNASIE 315
++EA E ++ ++ ++ L+ +L++ EKQ + CK QEN+K +H
Sbjct: 610 SIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETH 669
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH 375
+L+ Q+ K E E ++KE +A EE K +++ EE +QE
Sbjct: 670 TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK-----KQLQVKLEEEKTHLQEK 724
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE-LNNLKNCKDELSTEKFNFIEEIKT 434
Q + + + + Q+S +E + L ++ E+ + E T
Sbjct: 725 LRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHT 784
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
L+ E + K + E + +L EK E N TS + +S L+
Sbjct: 785 LEKEELRKEL-LEKHQRELQEGREKMETECN-IRTS-QIEAQFQSDCQKVTERCESALQS 841
Query: 495 LEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIME 553
LE + Q L +E E + ++ + +EC E +E L LK + + T+
Sbjct: 842 LEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER- 900
Query: 554 HNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXX 613
E L+ KE + + +L++D+E L+ S +Q L +++ + + +
Sbjct: 901 ------EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKREL 954
Query: 614 XXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTM 673
S L +Q L RLE E+++ L+ ++ + E
Sbjct: 955 REREEVLCQAGASEQLASQR---LERLEMEHDQ--EGQEMMSKLLAMENIHKATCETADR 1009
Query: 674 TVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKV-GKENMQ 714
A+ S+ I +L+ +++ Q S+L+ +V G+E ++
Sbjct: 1010 ERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1051
Score = 66.1 bits (154), Expect = 4e-10
Identities = 91/485 (18%), Positives = 217/485 (44%), Gaps = 36/485 (7%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF-NEIDRKLSKL 167
++++ R++++T KQI D KNEIA+LQ A +++H+ +E ++K ++
Sbjct: 658 ENMKQRHENETHT-LEKQISDLKNEIAELQG----QAAVLKEAHHEATCRHEEEKKQLQV 712
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
++ H + + E + + S E++ E L + + + E+V
Sbjct: 713 KLEEEKTHLQEKLRLQHEMELKARLTQAQAS----FEREREGLQSSAWTE-------EKV 761
Query: 228 ITVRDSLCKDLQEKLTS--NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L + QE+LTS + TL + + R E+++ H E E + E I ++
Sbjct: 762 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNIRTSQIE 821
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ + Q + +C+ ++L+ ++ ++ L+ Q +EK + E +L + E +
Sbjct: 822 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQECAEAQE 880
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
L++ + + + E ++ +EH + Q L Q++++L+ +++ Q S
Sbjct: 881 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR---NVSETQQS 937
Query: 406 DLKQELNNLKNCKDELSTEKFNFI------EEIKTLKDELIEKTINYENEKNKLNLAVEK 459
L ++ LK+ E+ + E++ + + E +E + E ++ L +
Sbjct: 938 LLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQEGQEMMSKLLAME 997
Query: 460 AIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNT 519
I K ET+ ++ ++ RL+ E++Q + ML S +V+ E
Sbjct: 998 NI-HKATCETADRERAEMSTEIS-RLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
Query: 520 LNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR-ELGTIKN 578
L + +++ ++ E ++L S+ + H + ++ NV + + +++ + E G + +
Sbjct: 1056 L-SLLQQGEQLLEENGDVLLSQ---QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS 1111
Query: 579 ELIED 583
+++
Sbjct: 1112 SCLDE 1116
Score = 55.2 bits (127), Expect = 8e-07
Identities = 102/520 (19%), Positives = 222/520 (42%), Gaps = 49/520 (9%)
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
+LD + ++ L+ E++ ++S+ Q L S + + +R++ V +
Sbjct: 338 SLDGNINLTELTLALENELLVTKNSIH---QAALASFKAEIRHLLERVDQVVREKE---K 391
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
+ + K++ + +++D+ AI + + + L ++ I +LKN++ KE+ +
Sbjct: 392 LRSDLDKAEKLK-SLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 450
Query: 329 LEQLHSQLIIKEQEM-KAKLEQ--IEESASEKLK---ICEIQFEERSQSIQEHCSQQEKT 382
L+Q Q + EQE+ KAK E+ I + + LK E + E ++ + E+ + K
Sbjct: 451 LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 510
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+ LE + E LD ++ + ++ L ++N E + +++ L+ EL E
Sbjct: 511 QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN---EYERQCRVLQDQVDELQSELEEY 567
Query: 443 TINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+ L N E+ E + + + L + + E++ +EQ+++Q
Sbjct: 568 RAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI-EAELVIEQMKEQHHR 626
Query: 502 -LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ + LE+++ Y+ L+ TV C + +E + +++ ++ +++ + ++
Sbjct: 627 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 686
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXX 620
V KEA+ E E + +++ +E + ++ EK R+ EM
Sbjct: 687 GQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ------EKLRLQHEMEL------- 733
Query: 621 XXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
+ L QA A R + L EL Q E+LT V K +
Sbjct: 734 ------KARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQ--EQLTSLVEKHTL 785
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTISPLR 720
++L+K+L + ++ L+ G+E M+T +R
Sbjct: 786 EKEELRKELLEKH---------QRELQEGREKMETECNIR 816
Score = 54.4 bits (125), Expect = 1e-06
Identities = 101/458 (22%), Positives = 202/458 (44%), Gaps = 45/458 (9%)
Query: 105 LVQAQDVEIRN-KDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEI--- 160
LV+ +DV K++ + ++ +E+ Q E+L+ + K +Q N+I NEI
Sbjct: 1481 LVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE-NSILRNEITTL 1539
Query: 161 --DRKLSKLRINNTNCHTEHNAVQGTDAEK-----VSAMINDMRSRIIELEKKCEALDNE 213
+ +S L++ N ++ Q T+ K V M+ +++ +I EL+ K + LD E
Sbjct: 1540 NEEDSISNLKLGTLN-GSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1598
Query: 214 VYDKQMELSSLEEVIT-----VRDSLCKDLQEK----LTSNELTLAETQQRLEMVKGHHA 264
+ + S +E + + + LC+ +E L E ++ LE K +
Sbjct: 1599 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1658
Query: 265 LALEANESIRREYKIELEALKTK----LDE-EKQAIISKCKVDQENLKTKHNASIESLKN 319
+ + E+ E KI+ ++ + DE EK + +C D + + K + S+ S
Sbjct: 1659 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKIS-SVLSYNE 1716
Query: 320 QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSI--QEHC 376
++LKEK E+L+S + + + LE + ++ K E Q +SQ + QE
Sbjct: 1717 KLLKEKEALSEELNS--CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1774
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
E T+Q + ++ +K L +T + LKQE+ +L K + ++ EI T
Sbjct: 1775 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH--KQLQNAGGKSWAPEIATHP 1832
Query: 437 DEL--IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
L +K ++++ + +N + +E + +T + T+ + ++R+ +S L
Sbjct: 1833 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1892
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
+ + E E + K RECD++++
Sbjct: 1893 KHQKHLNPSGTMNPTEQEKLSLK-------RECDQFQK 1923
Score = 50.8 bits (116), Expect = 2e-05
Identities = 136/635 (21%), Positives = 261/635 (41%), Gaps = 84/635 (13%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N ++T E + KN+I+QLQE L L ++ D + K ++
Sbjct: 1188 ELENSEETRTES----WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKI 1243
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC-EALDN------EVYDKQMELSSL 224
E + E VS + ++ + +E + EAL+N EV+ Q EL +
Sbjct: 1244 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1303
Query: 225 EEVITVRDSLCKDLQE-KLTSNELT--LAETQQRLE-----MVKGHHALALEAN-ESIRR 275
EEV SL K E K+ + EL + Q ++E +V+ EA+ E++
Sbjct: 1304 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEI 1363
Query: 276 EYKIELEALKTKLDE------EKQAIISKCKVDQENL--------KTK-H-----NASIE 315
E + L L+E +I +CK + + L K K H + +I+
Sbjct: 1364 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ 1423
Query: 316 S------LKNQMLKEKCEAL-----EQLHSQLIIKEQEM-KAKLEQIEESASEKLKICEI 363
+ ++NQ++ E+ L + Q I E E+ K KL+++ E++ I
Sbjct: 1424 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1483
Query: 364 QFE-----ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
Q + E+ + ++ + T ++Q+++ L+Y + +NS L+ E+ L N +
Sbjct: 1484 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-NEE 1542
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
D +S K + + ++E+ +KT + E N AV+K ++ K + L + +
Sbjct: 1543 DSISNLK---LGTLNGSQEEMWQKTETVKQE----NAAVQKMVENLKKQISELKIKNQQL 1595
Query: 479 HVLTLRLRESDSE-LEQLEDQVQMLTS---------AKEVLENELTTYKNTLNNTVRECD 528
+ L + +S+ E+L++ Q LT LE E K L + C
Sbjct: 1596 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNLKEELERCK 1654
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR--ELG----TIKNELIE 582
LV+ L+++ + K T I++ L++ K+ +R +L I + L
Sbjct: 1655 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1714
Query: 583 DVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +LLK++ + ++ +++ K +L S L +Q A ++
Sbjct: 1715 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1774
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+N + + +L + +QE E L V
Sbjct: 1775 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEV 1809
>X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein.
Length = 2349
Score = 68.5 bits (160), Expect = 8e-11
Identities = 97/497 (19%), Positives = 205/497 (41%), Gaps = 25/497 (5%)
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
++ T+A + A + ++ I E KK +A + ++ ++Q+E L+E +T S +
Sbjct: 660 IESTEAIEAKAALKQLQE-IFENYKKEKAENEKIQNEQLE--KLQEQVTDLRSQNTKIST 716
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI--ISK 298
+L Q +E + E N+ + + + + + T + + A ++
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV 776
Query: 299 CKVDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+V ENLK K + ++ +E A ++ + L+ Q ++ LE+ E ++
Sbjct: 777 AEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQR 836
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
L + + ++ S +K ++ ++ L LD+ Q D K++L+ N
Sbjct: 837 LS-------SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDV---QLLDTKRQLDTETNL 886
Query: 418 KDELSTEKF--NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVT 474
L+T++ N +EI TLK L + ++ ++ + + KE + + L T
Sbjct: 887 --HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQT 944
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
+ V+ L RL+ S S +EQ + M+TS +E L E + N E E
Sbjct: 945 EEQVNDLKERLKTSTSNVEQYQ---AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ 594
+ K + KE + + IES++ E + L +++NE+ E ++ +++
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 595 IKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXX 654
+ R+ E+ ++ E L A A +S++ + +
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA-AKEQVSKMASVRQHLEETTQKA 1120
Query: 655 XSLVVELSLLRQENEEL 671
S ++E +E E +
Sbjct: 1121 ESQLLECKASWEERERM 1137
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/470 (19%), Positives = 199/470 (42%), Gaps = 28/470 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K++ +S+K+ + P N L ++ Q Q +EI K+I + + E+AQ++
Sbjct: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR----FIRREKEIAETRFEVAQVE 1220
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ + + + ++ + K+++ ++ T+ V N M
Sbjct: 1221 SLRYRQRVELLERELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM-- 1278
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK--LTSNELTLAETQQRL 256
L ++ E L+ ++ Q ++ LE I +L EK + E L E +
Sbjct: 1279 ----LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKR 1334
Query: 257 EMVKGHHALALEANESIRREYKIELEA-LKTKLDEEKQAIISKCKVD--QENLKTKHNAS 313
+ H ++ + + K+ E + TK ++ I + K + + N +N +
Sbjct: 1335 WKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394
Query: 314 -IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE--SASEKLKICEIQFEERSQ 370
I+SLK + K + E E + L K +++ K++ I + + K + + +
Sbjct: 1395 LIQSLKEDLNKVRTEK-ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQD 1453
Query: 371 SIQEHCSQQ--EKTIQYLE-QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ E +Q + Q++ QE++ELK TL+ ++ L+ ++ NL+ E TE N
Sbjct: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARN 1513
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD-IVHVLTLRLR 486
E+ L+ EL + ++ + ++ +++ K ++ + I H+ ++
Sbjct: 1514 LQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK-D 1572
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTT----YKNTLNNTVRECDEYKE 532
+ E E+L+ + L K+ L+ +T Y+ ++ RE E++E
Sbjct: 1573 QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 62.5 bits (145), Expect = 5e-09
Identities = 88/461 (19%), Positives = 193/461 (41%), Gaps = 36/461 (7%)
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
++L ++ N E+ +Q EK+ + D+RS+ ++ + + Q +
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
IT + L E + Q L A+A E++++E K L
Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE-KEML 791
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ + +L +++++++++ + Q L T ++++++ + + + E ++L SQ+ E
Sbjct: 792 KLSEVRLSQQRESLLAEQR-GQNLLLT----NLQTIQGILERSETETKQRLSSQIEKLEH 846
Query: 342 E---MKAKLEQIEESASEKLKICEIQFEERSQSI----------QEHCSQQEKTIQYLEQ 388
E +K KLE E + ++Q + + + +E +K I L+Q
Sbjct: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ ++ + ++Q + Q N K D+L ++ E++ LK+ L T N E
Sbjct: 907 HLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
+ + E KEK VT ++ + +RL+ES QLE ++ + K+
Sbjct: 965 YQAMVTSLEESLNKEK-------QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE 1017
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L+++ + + + ++ E K+ L ++ + + + + Q K
Sbjct: 1018 LQDD---KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
Query: 569 AYRELGTIKNELI---EDVELLK--KESNSQIKFLREEVEK 604
A + EL+ DVE L+ KE S++ +R+ +E+
Sbjct: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
Score = 60.9 bits (141), Expect = 2e-08
Identities = 87/489 (17%), Positives = 206/489 (42%), Gaps = 26/489 (5%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
Q + R++ +T + QIE ++EI+ L++ L+ + N+D +D K +
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK--RQL 880
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-LSSLEEV 227
TN H + ++++ + + + +++ + + E + L
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL-EALKT 286
+ + DL+E+L ++ + + Q + ++ + E +R+ ++ L E+ +
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK 346
+ EK+ + + + +++ L+ +IES++ Q L +L L + E++
Sbjct: 1001 QTQLEKK--LMEVEKEKQELQDDKRRAIESMEQQ--------LSELKKTLSSVQNEVQEA 1050
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD 406
L++ + S + + +E+++ E ++ E+ + +++ L+ + + S
Sbjct: 1051 LQRASTALSNEQQ-ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASV 1109
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
+ + + +L K ++ E + LKDE + K + + K N + I EK
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDE-VSKCVCRCEDLEKQNRLLHDQI-EKLS 1167
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN-------ELTTYKNT 519
+ SV + L + L E EQ+ + ++ + KE+ E E Y+
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 520 LNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNE 579
+ RE E +++L N + K +T + E + E++ NV E + L K
Sbjct: 1228 VELLERELQELEDSL-NAEREKVQVTAKTMAQHEELMKKTETM-NVVMETNKMLREEKER 1285
Query: 580 LIEDVELLK 588
L +D++ ++
Sbjct: 1286 LEQDLQQMQ 1294
Score = 58.4 bits (135), Expect = 8e-08
Identities = 103/524 (19%), Positives = 216/524 (41%), Gaps = 47/524 (8%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDFNEID 161
V+ + RN D + + +Q++ N +E+LK E+AT +Q +N++ ++
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-LKQHLSNMEV-QVA 916
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+ S+ + E + + +ND++ R+ E V + L
Sbjct: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 222 SSLEEVIT-VRDSL---CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY 277
+ ++V VR ++ K+ E T E L E ++ + ++ A+E+ E E
Sbjct: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIE-SLKNQMLKE------KCEAL 329
K L +++ ++ E Q + +Q+ + + A I +N+ +E EAL
Sbjct: 1037 KKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE-------HCSQQEKT 382
+ Q + K ++ LE+ + A +L C+ +EER + +++ C EK
Sbjct: 1097 QAAKEQ-VSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
Query: 383 IQYLEQEIKEL--KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI 440
+ L +I++L K + L L+ ++++ E FI K + +
Sbjct: 1156 NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI-LEILRFIRREKEIAETRF 1214
Query: 441 EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE---- 496
E + E + VE +E + E SL+ R+ V V + + + +++ E
Sbjct: 1215 EVA---QVESLRYRQRVELLERELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNV 1271
Query: 497 --DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+ +ML KE LE +L + + + +EA L K+ + + +++E
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAE-LSEKSGMLQAEKKLLEE 1330
Query: 555 NVT--------LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+V L+ ++ + E YR+L + K + ++ L +E
Sbjct: 1331 DVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
>AY736182-1|AAU86898.1| 1989|Homo sapiens ninein isoform 6 protein.
Length = 1989
Score = 68.5 bits (160), Expect = 8e-11
Identities = 133/643 (20%), Positives = 258/643 (40%), Gaps = 41/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
K+ + KN++ + E + Q + R + + E K E+Y + L LKE +
Sbjct: 427 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS--LKENSRLE 484
Query: 149 RQSHNNID-FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ N + E + +KL+ N N E + + + E E++C
Sbjct: 485 NELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544
Query: 208 EALDNEVYDKQMELSSLEEVITV-RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA-L 265
L ++V + Q EL V R L E++ +N + E + L + + +
Sbjct: 545 RVLQDQVDELQSELEEYRAQGRVFRLPLKNSPSEEVEANSGGI-EPEHGLGSEECNPLNM 603
Query: 266 ALEAN---ESIRREYKIELEALKTKLDE-----EKQA--IISKCKVDQENLKTKHNASIE 315
++EA E ++ ++ ++ L+ +L++ EKQ + CK QEN+K +H
Sbjct: 604 SIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETH 663
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH 375
+L+ Q+ K E E ++KE +A EE K +++ EE +QE
Sbjct: 664 TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK-----KQLQVKLEEEKTHLQEK 718
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE-LNNLKNCKDELSTEKFNFIEEIKT 434
Q + + + + Q+S +E + L ++ E+ + E T
Sbjct: 719 LRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHT 778
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT-RDIVHVLTLRLRESDSELE 493
L+ E + K + E + +L EK E N+ T + + +T R +S L+
Sbjct: 779 LEKEELRKEL-LEKHQRELQEGREKMETECNRRTTQIEAQFQSDCQKVTER---CESALQ 834
Query: 494 QLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
LE + Q L +E E + ++ + +EC E +E L LK + + T+
Sbjct: 835 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 894
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX 612
E L+ KE + + +L++D+E L+ S +Q L +++ + +
Sbjct: 895 -------EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHIRE 947
Query: 613 XXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELT 672
S L +Q L RLE E+ + L+ ++ + E
Sbjct: 948 LREREEVLCQAGASEQLASQR---LERLEMEHAQ--ERQEMMSKLLAMENIHKATCETAD 1002
Query: 673 MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKV-GKENMQ 714
A+ S+ I +L+ +++ Q S+L+ +V G+E ++
Sbjct: 1003 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
Score = 61.3 bits (142), Expect = 1e-08
Identities = 88/484 (18%), Positives = 212/484 (43%), Gaps = 34/484 (7%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF-NEIDRKLSKL 167
++++ R++++T KQI D KNEIA+LQ A +++H+ +E ++K ++
Sbjct: 652 ENMKQRHENETHT-LEKQISDLKNEIAELQG----QAAVLKEAHHEATCRHEEEKKQLQV 706
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
++ H + + E + + S E++ E L + + + E+V
Sbjct: 707 KLEEEKTHLQEKLRLQHEMELKARLTQAQAS----FEREREGLQSSAWTE-------EKV 755
Query: 228 ITVRDSLCKDLQEKLTS--NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L + QE+LTS + TL + + R E+++ H E E + E ++
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTTQIE 815
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ + Q + +C+ ++L+ ++ ++ L+ Q +EK + E +L + E +
Sbjct: 816 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQECAEAQE 874
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
L++ + + + E ++ +EH + Q L Q++++L+ +++ Q S
Sbjct: 875 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR---NVSETQQS 931
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEI---KTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L ++ LK+ E+ + + + L + +E+ + E+ + + + +
Sbjct: 932 LLSDQILELKSSHIRELREREEVLCQAGASEQLASQRLER-LEMEHAQERQEMMSKLLAM 990
Query: 463 EKNKFETSLSVTRDIVHVLT--LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
E T + R+ + T RL+ E++Q + ML S +V+ E L
Sbjct: 991 ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1050
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR-ELGTIKNE 579
+ + + ++ E ++ S L + H + ++ NV + + +++ + E G + +
Sbjct: 1051 -SLLHQGEQLLEENGDVFLS---LQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1106
Query: 580 LIED 583
+++
Sbjct: 1107 CLDE 1110
Score = 55.2 bits (127), Expect = 8e-07
Identities = 101/515 (19%), Positives = 221/515 (42%), Gaps = 49/515 (9%)
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
+LD + ++ L+ E++ ++S+ Q L S + + +R++ V +
Sbjct: 332 SLDGNINLTELTLALENELLVTKNSIH---QAALASFKAEVRHLLERVDQVVREKE---K 385
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
+ + K++ ++ +++D+ AI + + + L ++ I +LKN++ KE+ +
Sbjct: 386 LRSDLDKAEKLK-SSMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 444
Query: 329 LEQLHSQLIIKEQEM-KAKLEQ--IEESASEKLK---ICEIQFEERSQSIQEHCSQQEKT 382
L+Q Q + EQE+ KAK E+ I + + LK E + E ++ + E+ + K
Sbjct: 445 LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 504
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+ LE + E LD ++ + ++ L ++N E + +++ L+ EL E
Sbjct: 505 QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN---EYERQCRVLQDQVDELQSELEEY 561
Query: 443 TINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+ L N E+ E + + + L + + E++ +EQ+++Q
Sbjct: 562 RAQGRVFRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI-EAELVIEQMKEQHHR 620
Query: 502 -LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ + LE+++ Y+ L+ TV C + +E + +++ ++ +++ + ++
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 680
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXX 620
V KEA+ E E + +++ +E + ++ EK R+ EM
Sbjct: 681 GQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ------EKLRLQHEMEL------- 727
Query: 621 XXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
+ L QA A R + L EL Q E+LT V K +
Sbjct: 728 ------KARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQ--EQLTSLVEKHTL 779
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQT 715
++L+K+L + ++ L+ G+E M+T
Sbjct: 780 EKEELRKELLEKH---------QRELQEGREKMET 805
Score = 54.4 bits (125), Expect = 1e-06
Identities = 101/458 (22%), Positives = 202/458 (44%), Gaps = 45/458 (9%)
Query: 105 LVQAQDVEIRN-KDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEI--- 160
LV+ +DV K++ + ++ +E+ Q E+L+ + K +Q N+I NEI
Sbjct: 1475 LVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE-NSILRNEITTL 1533
Query: 161 --DRKLSKLRINNTNCHTEHNAVQGTDAEK-----VSAMINDMRSRIIELEKKCEALDNE 213
+ +S L++ N ++ Q T+ K V M+ +++ +I EL+ K + LD E
Sbjct: 1534 NEEDSISNLKLGTLN-GSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
Query: 214 VYDKQMELSSLEEVIT-----VRDSLCKDLQEK----LTSNELTLAETQQRLEMVKGHHA 264
+ + S +E + + + LC+ +E L E ++ LE K +
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
Query: 265 LALEANESIRREYKIELEALKTK----LDE-EKQAIISKCKVDQENLKTKHNASIESLKN 319
+ + E+ E KI+ ++ + DE EK + +C D + + K + S+ S
Sbjct: 1653 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKIS-SVLSYNE 1710
Query: 320 QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSI--QEHC 376
++LKEK E+L+S + + + LE + ++ K E Q +SQ + QE
Sbjct: 1711 KLLKEKEALSEELNS--CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1768
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
E T+Q + ++ +K L +T + LKQE+ +L K + ++ EI T
Sbjct: 1769 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH--KQLQNAGGKSWAPEIATHP 1826
Query: 437 DEL--IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
L +K ++++ + +N + +E + +T + T+ + ++R+ +S L
Sbjct: 1827 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1886
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
+ + E E + K RECD++++
Sbjct: 1887 KHQKHLNPSGTMNPTEQEKLSLK-------RECDQFQK 1917
Score = 51.2 bits (117), Expect = 1e-05
Identities = 136/635 (21%), Positives = 261/635 (41%), Gaps = 84/635 (13%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N ++T E + KN+I+QLQE L L ++ D + K ++
Sbjct: 1182 ELENSEETRTES----WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM 1237
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC-EALDN------EVYDKQMELSSL 224
E + E VS + ++ + +E + EAL+N EV+ Q EL +
Sbjct: 1238 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
Query: 225 EEVITVRDSLCKDLQE-KLTSNELT--LAETQQRLE-----MVKGHHALALEAN-ESIRR 275
EEV SL K E K+ + EL + Q ++E +V+ EA+ E++
Sbjct: 1298 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEI 1357
Query: 276 EYKIELEALKTKLDE------EKQAIISKCKVDQENL--------KTK-H-----NASIE 315
E + L L+E +I +CK + + L K K H + +I+
Sbjct: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ 1417
Query: 316 S------LKNQMLKEKCEAL-----EQLHSQLIIKEQEM-KAKLEQIEESASEKLKICEI 363
+ ++NQ++ E+ L + Q I E E+ K KL+++ E++ I
Sbjct: 1418 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1477
Query: 364 QFE-----ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
Q + E+ + ++ + T ++Q+++ L+Y + +NS L+ E+ L N +
Sbjct: 1478 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-NEE 1536
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
D +S K + + ++E+ +KT + E N AV+K ++ K + L + +
Sbjct: 1537 DSISNLK---LGTLNGSQEEMWQKTETVKQE----NAAVQKMVENLKKQISELKIKNQQL 1589
Query: 479 HVLTLRLRESDSE-LEQLEDQVQMLTS---------AKEVLENELTTYKNTLNNTVRECD 528
+ L + +S+ E+L++ Q LT LE E K L + C
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNLKEELERCK 1648
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR--ELG----TIKNELIE 582
LV+ L+++ + K T I++ L++ K+ +R +L I + L
Sbjct: 1649 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1708
Query: 583 DVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +LLK++ + ++ +++ K +L S L +Q A ++
Sbjct: 1709 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1768
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+N + + +L + +QE E L V
Sbjct: 1769 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEV 1803
>AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 68.5 bits (160), Expect = 8e-11
Identities = 97/497 (19%), Positives = 205/497 (41%), Gaps = 25/497 (5%)
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
++ T+A + A + ++ I E KK +A + ++ ++Q+E L+E +T S +
Sbjct: 660 IESTEAIEAKAALKQLQE-IFENYKKEKAENEKIQNEQLE--KLQEQVTDLRSQNTKIST 716
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI--ISK 298
+L Q +E + E N+ + + + + + T + + A ++
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV 776
Query: 299 CKVDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+V ENLK K + ++ +E A ++ + L+ Q ++ LE+ E ++
Sbjct: 777 AEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQR 836
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
L + + ++ S +K ++ ++ L LD+ Q D K++L+ N
Sbjct: 837 LS-------SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDV---QLLDTKRQLDTETNL 886
Query: 418 KDELSTEKF--NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVT 474
L+T++ N +EI TLK L + ++ ++ + + KE + + L T
Sbjct: 887 --HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQT 944
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
+ V+ L RL+ S S +EQ + M+TS +E L E + N E E
Sbjct: 945 EEQVNDLKERLKTSTSNVEQYQ---AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ 594
+ K + KE + + IES++ E + L +++NE+ E ++ +++
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 595 IKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXX 654
+ R+ E+ ++ E L A A +S++ + +
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA-AKEQVSKMASVRQHLEETTQKA 1120
Query: 655 XSLVVELSLLRQENEEL 671
S ++E +E E +
Sbjct: 1121 ESQLLECKASWEERERM 1137
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/470 (19%), Positives = 199/470 (42%), Gaps = 28/470 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K++ +S+K+ + P N L ++ Q Q +EI K+I + + E+AQ++
Sbjct: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR----FIRREKEIAETRFEVAQVE 1220
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ + + + ++ + K+++ ++ T+ V N M
Sbjct: 1221 SLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM-- 1278
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK--LTSNELTLAETQQRL 256
L ++ E L+ ++ Q ++ LE I +L EK + E L E +
Sbjct: 1279 ----LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKR 1334
Query: 257 EMVKGHHALALEANESIRREYKIELEA-LKTKLDEEKQAIISKCKVD--QENLKTKHNAS 313
+ H ++ + + K+ E + TK ++ I + K + + N +N +
Sbjct: 1335 WKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394
Query: 314 -IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE--SASEKLKICEIQFEERSQ 370
I+SLK + K + E E + L K +++ K++ I + + K + + +
Sbjct: 1395 LIQSLKEDLNKVRTEK-ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQD 1453
Query: 371 SIQEHCSQQ--EKTIQYLE-QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ E +Q + Q++ QE++ELK TL+ ++ L+ ++ NL+ E TE N
Sbjct: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARN 1513
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD-IVHVLTLRLR 486
E+ L+ EL + ++ + ++ +++ K ++ + I H+ ++
Sbjct: 1514 LQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK-D 1572
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTT----YKNTLNNTVRECDEYKE 532
+ E E+L+ + L K+ L+ +T Y+ ++ RE E++E
Sbjct: 1573 QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 62.5 bits (145), Expect = 5e-09
Identities = 88/461 (19%), Positives = 193/461 (41%), Gaps = 36/461 (7%)
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
++L ++ N E+ +Q EK+ + D+RS+ ++ + + Q +
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
IT + L E + Q L A+A E++++E K L
Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE-KEML 791
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ + +L +++++++++ + Q L T ++++++ + + + E ++L SQ+ E
Sbjct: 792 KLSEVRLSQQRESLLAEQR-GQNLLLT----NLQTIQGILERSETETKQRLSSQIEKLEH 846
Query: 342 E---MKAKLEQIEESASEKLKICEIQFEERSQSI----------QEHCSQQEKTIQYLEQ 388
E +K KLE E + ++Q + + + +E +K I L+Q
Sbjct: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ ++ + ++Q + Q N K D+L ++ E++ LK+ L T N E
Sbjct: 907 HLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
+ + E KEK VT ++ + +RL+ES QLE ++ + K+
Sbjct: 965 YQAMVTSLEESLNKEK-------QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE 1017
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L+++ + + + ++ E K+ L ++ + + + + Q K
Sbjct: 1018 LQDD---KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
Query: 569 AYRELGTIKNELI---EDVELLK--KESNSQIKFLREEVEK 604
A + EL+ DVE L+ KE S++ +R+ +E+
Sbjct: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
Score = 60.9 bits (141), Expect = 2e-08
Identities = 87/489 (17%), Positives = 206/489 (42%), Gaps = 26/489 (5%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
Q + R++ +T + QIE ++EI+ L++ L+ + N+D +D K +
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK--RQL 880
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-LSSLEEV 227
TN H + ++++ + + + +++ + + E + L
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL-EALKT 286
+ + DL+E+L ++ + + Q + ++ + E +R+ ++ L E+ +
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK 346
+ EK+ + + + +++ L+ +IES++ Q L +L L + E++
Sbjct: 1001 QTQLEKK--LMEVEKEKQELQDDKRRAIESMEQQ--------LSELKKTLSSVQNEVQEA 1050
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD 406
L++ + S + + +E+++ E ++ E+ + +++ L+ + + S
Sbjct: 1051 LQRASTALSNEQQ-ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASV 1109
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
+ + + +L K ++ E + LKDE + K + + K N + I EK
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDE-VSKCVCRCEDLEKQNRLLHDQI-EKLS 1167
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN-------ELTTYKNT 519
+ SV + L + L E EQ+ + ++ + KE+ E E Y+
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 520 LNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNE 579
+ RE E +++L N + K +T + E + E++ NV E + L K
Sbjct: 1228 VELLERELQELQDSL-NAEREKVQVTAKTMAQHEELMKKTETM-NVVMETNKMLREEKER 1285
Query: 580 LIEDVELLK 588
L +D++ ++
Sbjct: 1286 LEQDLQQMQ 1294
Score = 57.2 bits (132), Expect = 2e-07
Identities = 102/524 (19%), Positives = 216/524 (41%), Gaps = 47/524 (8%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDFNEID 161
V+ + RN D + + +Q++ N +E+LK E+AT +Q +N++ ++
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-LKQHLSNMEV-QVA 916
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+ S+ + E + + +ND++ R+ E V + L
Sbjct: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 222 SSLEEVIT-VRDSL---CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY 277
+ ++V VR ++ K+ E T E L E ++ + ++ A+E+ E E
Sbjct: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIE-SLKNQMLKE------KCEAL 329
K L +++ ++ E Q + +Q+ + + A I +N+ +E EAL
Sbjct: 1037 KKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE-------HCSQQEKT 382
+ Q + K ++ LE+ + A +L C+ +EER + +++ C EK
Sbjct: 1097 QAAKEQ-VSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
Query: 383 IQYLEQEIKEL--KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI 440
+ L +I++L K + L L+ ++++ E FI K + +
Sbjct: 1156 NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI-LEILRFIRREKEIAETRF 1214
Query: 441 EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE---- 496
E + E + VE +E + + SL+ R+ V V + + + +++ E
Sbjct: 1215 EVA---QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNV 1271
Query: 497 --DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+ +ML KE LE +L + + + +EA L K+ + + +++E
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAE-LSEKSGMLQAEKKLLEE 1330
Query: 555 NVT--------LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+V L+ ++ + E YR+L + K + ++ L +E
Sbjct: 1331 DVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
>AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 68.5 bits (160), Expect = 8e-11
Identities = 97/497 (19%), Positives = 205/497 (41%), Gaps = 25/497 (5%)
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
++ T+A + A + ++ I E KK +A + ++ ++Q+E L+E +T S +
Sbjct: 660 IESTEAIEAKAALKQLQE-IFENYKKEKAENEKIQNEQLE--KLQEQVTDLRSQNTKIST 716
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI--ISK 298
+L Q +E + E N+ + + + + + T + + A ++
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV 776
Query: 299 CKVDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
+V ENLK K + ++ +E A ++ + L+ Q ++ LE+ E ++
Sbjct: 777 AEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQR 836
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
L + + ++ S +K ++ ++ L LD+ Q D K++L+ N
Sbjct: 837 LS-------SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDV---QLLDTKRQLDTETNL 886
Query: 418 KDELSTEKF--NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVT 474
L+T++ N +EI TLK L + ++ ++ + + KE + + L T
Sbjct: 887 --HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQT 944
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
+ V+ L RL+ S S +EQ + M+TS +E L E + N E E
Sbjct: 945 EEQVNDLKERLKTSTSNVEQYQ---AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ 594
+ K + KE + + IES++ E + L +++NE+ E ++ +++
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 595 IKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXX 654
+ R+ E+ ++ E L A A +S++ + +
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA-AKEQVSKMASVRQHLEETTQKA 1120
Query: 655 XSLVVELSLLRQENEEL 671
S ++E +E E +
Sbjct: 1121 ESQLLECKASWEERERM 1137
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/470 (19%), Positives = 199/470 (42%), Gaps = 28/470 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K++ +S+K+ + P N L ++ Q Q +EI K+I + + E+AQ++
Sbjct: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR----FIRREKEIAETRFEVAQVE 1220
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ + + + ++ + K+++ ++ T+ V N M
Sbjct: 1221 SLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM-- 1278
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK--LTSNELTLAETQQRL 256
L ++ E L+ ++ Q ++ LE I +L EK + E L E +
Sbjct: 1279 ----LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKR 1334
Query: 257 EMVKGHHALALEANESIRREYKIELEA-LKTKLDEEKQAIISKCKVD--QENLKTKHNAS 313
+ H ++ + + K+ E + TK ++ I + K + + N +N +
Sbjct: 1335 WKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394
Query: 314 -IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE--SASEKLKICEIQFEERSQ 370
I+SLK + K + E E + L K +++ K++ I + + K + + +
Sbjct: 1395 LIQSLKEDLNKVRTEK-ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQD 1453
Query: 371 SIQEHCSQQ--EKTIQYLE-QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ E +Q + Q++ QE++ELK TL+ ++ L+ ++ NL+ E TE N
Sbjct: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARN 1513
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD-IVHVLTLRLR 486
E+ L+ EL + ++ + ++ +++ K ++ + I H+ ++
Sbjct: 1514 LQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK-D 1572
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTT----YKNTLNNTVRECDEYKE 532
+ E E+L+ + L K+ L+ +T Y+ ++ RE E++E
Sbjct: 1573 QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 62.5 bits (145), Expect = 5e-09
Identities = 88/461 (19%), Positives = 193/461 (41%), Gaps = 36/461 (7%)
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
++L ++ N E+ +Q EK+ + D+RS+ ++ + + Q +
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 222 SSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
IT + L E + Q L A+A E++++E K L
Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE-KEML 791
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ + +L +++++++++ + Q L T ++++++ + + + E ++L SQ+ E
Sbjct: 792 KLSEVRLSQQRESLLAEQR-GQNLLLT----NLQTIQGILERSETETKQRLSSQIEKLEH 846
Query: 342 E---MKAKLEQIEESASEKLKICEIQFEERSQSI----------QEHCSQQEKTIQYLEQ 388
E +K KLE E + ++Q + + + +E +K I L+Q
Sbjct: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906
Query: 389 EIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYEN 448
+ ++ + ++Q + Q N K D+L ++ E++ LK+ L T N E
Sbjct: 907 HLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
Query: 449 EKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEV 508
+ + E KEK VT ++ + +RL+ES QLE ++ + K+
Sbjct: 965 YQAMVTSLEESLNKEK-------QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE 1017
Query: 509 LENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKE 568
L+++ + + + ++ E K+ L ++ + + + + Q K
Sbjct: 1018 LQDD---KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
Query: 569 AYRELGTIKNELI---EDVELLK--KESNSQIKFLREEVEK 604
A + EL+ DVE L+ KE S++ +R+ +E+
Sbjct: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
Score = 60.9 bits (141), Expect = 2e-08
Identities = 87/489 (17%), Positives = 206/489 (42%), Gaps = 26/489 (5%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
Q + R++ +T + QIE ++EI+ L++ L+ + N+D +D K +
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK--RQL 880
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-LSSLEEV 227
TN H + ++++ + + + +++ + + E + L
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL-EALKT 286
+ + DL+E+L ++ + + Q + ++ + E +R+ ++ L E+ +
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK 346
+ EK+ + + + +++ L+ +IES++ Q L +L L + E++
Sbjct: 1001 QTQLEKK--LMEVEKEKQELQDDKRRAIESMEQQ--------LSELKKTLSSVQNEVQEA 1050
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD 406
L++ + S + + +E+++ E ++ E+ + +++ L+ + + S
Sbjct: 1051 LQRASTALSNEQQ-ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASV 1109
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
+ + + +L K ++ E + LKDE + K + + K N + I EK
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDE-VSKCVCRCEDLEKQNRLLHDQI-EKLS 1167
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN-------ELTTYKNT 519
+ SV + L + L E EQ+ + ++ + KE+ E E Y+
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 520 LNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNE 579
+ RE E +++L N + K +T + E + E++ NV E + L K
Sbjct: 1228 VELLERELQELQDSL-NAEREKVQVTAKTMAQHEELMKKTETM-NVVMETNKMLREEKER 1285
Query: 580 LIEDVELLK 588
L +D++ ++
Sbjct: 1286 LEQDLQQMQ 1294
Score = 57.2 bits (132), Expect = 2e-07
Identities = 102/524 (19%), Positives = 216/524 (41%), Gaps = 47/524 (8%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILK----ELATKFRQSHNNIDFNEID 161
V+ + RN D + + +Q++ N +E+LK E+AT +Q +N++ ++
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-LKQHLSNMEV-QVA 916
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMEL 221
+ S+ + E + + +ND++ R+ E V + L
Sbjct: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 222 SSLEEVIT-VRDSL---CKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREY 277
+ ++V VR ++ K+ E T E L E ++ + ++ A+E+ E E
Sbjct: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 278 KIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIE-SLKNQMLKE------KCEAL 329
K L +++ ++ E Q + +Q+ + + A I +N+ +E EAL
Sbjct: 1037 KKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Query: 330 EQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE-------HCSQQEKT 382
+ Q + K ++ LE+ + A +L C+ +EER + +++ C EK
Sbjct: 1097 QAAKEQ-VSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
Query: 383 IQYLEQEIKEL--KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELI 440
+ L +I++L K + L L+ ++++ E FI K + +
Sbjct: 1156 NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI-LEILRFIRREKEIAETRF 1214
Query: 441 EKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE---- 496
E + E + VE +E + + SL+ R+ V V + + + +++ E
Sbjct: 1215 EVA---QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNV 1271
Query: 497 --DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEH 554
+ +ML KE LE +L + + + +EA L K+ + + +++E
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAE-LSEKSGMLQAEKKLLEE 1330
Query: 555 NVT--------LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+V L+ ++ + E YR+L + K + ++ L +E
Sbjct: 1331 DVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
>AF302773-1|AAG33512.2| 2090|Homo sapiens ninein-Lm isoform protein.
Length = 2090
Score = 68.5 bits (160), Expect = 8e-11
Identities = 133/643 (20%), Positives = 258/643 (40%), Gaps = 41/643 (6%)
Query: 89 KKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKF 148
K+ + KN++ + E + Q + R + + E K E+Y + L LKE +
Sbjct: 427 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALS--LKENSRLE 484
Query: 149 RQSHNNID-FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC 207
+ N + E + +KL+ N N E + + + E E++C
Sbjct: 485 NELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQC 544
Query: 208 EALDNEVYDKQMELSSLEEVITV-RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHA-L 265
L ++V + Q EL V R L E++ +N + E + L + + +
Sbjct: 545 RVLQDQVDELQSELEEYRAQGRVFRLPLKNSPSEEVEANSGGI-EPEHGLGSEECNPLNM 603
Query: 266 ALEAN---ESIRREYKIELEALKTKLDE-----EKQA--IISKCKVDQENLKTKHNASIE 315
++EA E ++ ++ ++ L+ +L++ EKQ + CK QEN+K +H
Sbjct: 604 SIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETH 663
Query: 316 SLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEH 375
+L+ Q+ K E E ++KE +A EE K +++ EE +QE
Sbjct: 664 TLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK-----KQLQVKLEEEKTHLQEK 718
Query: 376 CSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE-LNNLKNCKDELSTEKFNFIEEIKT 434
Q + + + + Q+S +E + L ++ E+ + E T
Sbjct: 719 LRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHT 778
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT-RDIVHVLTLRLRESDSELE 493
L+ E + K + E + +L EK E N+ T + + +T R +S L+
Sbjct: 779 LEKEELRKEL-LEKHQRELQEGREKMETECNRRTTQIEAQFQSDCQKVTER---CESALQ 834
Query: 494 QLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIM 552
LE + Q L +E E + ++ + +EC E +E L LK + + T+
Sbjct: 835 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 894
Query: 553 EHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMX 612
E L+ KE + + +L++D+E L+ S +Q L +++ + +
Sbjct: 895 -------EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHIRE 947
Query: 613 XXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELT 672
S L +Q L RLE E+ + L+ ++ + E
Sbjct: 948 LREREEVLCQAGASEQLASQR---LERLEMEHAQ--ERQEMMSKLLAMENIHKATCETAD 1002
Query: 673 MTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKV-GKENMQ 714
A+ S+ I +L+ +++ Q S+L+ +V G+E ++
Sbjct: 1003 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVE 1045
Score = 61.3 bits (142), Expect = 1e-08
Identities = 88/484 (18%), Positives = 212/484 (43%), Gaps = 34/484 (7%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF-NEIDRKLSKL 167
++++ R++++T KQI D KNEIA+LQ A +++H+ +E ++K ++
Sbjct: 652 ENMKQRHENETHT-LEKQISDLKNEIAELQG----QAAVLKEAHHEATCRHEEEKKQLQV 706
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
++ H + + E + + S E++ E L + + + E+V
Sbjct: 707 KLEEEKTHLQEKLRLQHEMELKARLTQAQAS----FEREREGLQSSAWTE-------EKV 755
Query: 228 ITVRDSLCKDLQEKLTS--NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L + QE+LTS + TL + + R E+++ H E E + E ++
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTTQIE 815
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ + Q + +C+ ++L+ ++ ++ L+ Q +EK + E +L + E +
Sbjct: 816 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQECAEAQE 874
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
L++ + + + E ++ +EH + Q L Q++++L+ +++ Q S
Sbjct: 875 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR---NVSETQQS 931
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEI---KTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L ++ LK+ E+ + + + L + +E+ + E+ + + + +
Sbjct: 932 LLSDQILELKSSHIRELREREEVLCQAGASEQLASQRLER-LEMEHAQERQEMMSKLLAM 990
Query: 463 EKNKFETSLSVTRDIVHVLT--LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
E T + R+ + T RL+ E++Q + ML S +V+ E L
Sbjct: 991 ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGAL 1050
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR-ELGTIKNE 579
+ + + ++ E ++ S L + H + ++ NV + + +++ + E G + +
Sbjct: 1051 -SLLHQGEQLLEENGDVFLS---LQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1106
Query: 580 LIED 583
+++
Sbjct: 1107 CLDE 1110
Score = 55.2 bits (127), Expect = 8e-07
Identities = 101/515 (19%), Positives = 221/515 (42%), Gaps = 49/515 (9%)
Query: 209 ALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALE 268
+LD + ++ L+ E++ ++S+ Q L S + + +R++ V +
Sbjct: 332 SLDGNINLTELTLALENELLVTKNSIH---QAALASFKAEVRHLLERVDQVVREKE---K 385
Query: 269 ANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEA 328
+ + K++ ++ +++D+ AI + + + L ++ I +LKN++ KE+ +
Sbjct: 386 LRSDLDKAEKLK-SSMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQI 444
Query: 329 LEQLHSQLIIKEQEM-KAKLEQ--IEESASEKLK---ICEIQFEERSQSIQEHCSQQEKT 382
L+Q Q + EQE+ KAK E+ I + + LK E + E ++ + E+ + K
Sbjct: 445 LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKL 504
Query: 383 IQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEK 442
+ LE + E LD ++ + ++ L ++N E + +++ L+ EL E
Sbjct: 505 QRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN---EYERQCRVLQDQVDELQSELEEY 561
Query: 443 TINYENEKNKL-NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM 501
+ L N E+ E + + + L + + E++ +EQ+++Q
Sbjct: 562 RAQGRVFRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSI-EAELVIEQMKEQHHR 620
Query: 502 -LTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIE 560
+ + LE+++ Y+ L+ TV C + +E + +++ ++ +++ + ++
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ 680
Query: 561 SLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXX 620
V KEA+ E E + +++ +E + ++ EK R+ EM
Sbjct: 681 GQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQ------EKLRLQHEMEL------- 727
Query: 621 XXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSS 680
+ L QA A R + L EL Q E+LT V K +
Sbjct: 728 ------KARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQ--EQLTSLVEKHTL 779
Query: 681 IIDKLKKDLEQSQYTPKSPSVLRKSLKVGKENMQT 715
++L+K+L + ++ L+ G+E M+T
Sbjct: 780 EKEELRKELLEKH---------QRELQEGREKMET 805
Score = 54.4 bits (125), Expect = 1e-06
Identities = 101/458 (22%), Positives = 202/458 (44%), Gaps = 45/458 (9%)
Query: 105 LVQAQDVEIRN-KDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEI--- 160
LV+ +DV K++ + ++ +E+ Q E+L+ + K +Q N+I NEI
Sbjct: 1475 LVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQE-NSILRNEITTL 1533
Query: 161 --DRKLSKLRINNTNCHTEHNAVQGTDAEK-----VSAMINDMRSRIIELEKKCEALDNE 213
+ +S L++ N ++ Q T+ K V M+ +++ +I EL+ K + LD E
Sbjct: 1534 NEEDSISNLKLGTLN-GSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
Query: 214 VYDKQMELSSLEEVIT-----VRDSLCKDLQEK----LTSNELTLAETQQRLEMVKGHHA 264
+ + S +E + + + LC+ +E L E ++ LE K +
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
Query: 265 LALEANESIRREYKIELEALKTK----LDE-EKQAIISKCKVDQENLKTKHNASIESLKN 319
+ + E+ E KI+ ++ + DE EK + +C D + + K + S+ S
Sbjct: 1653 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKIS-SVLSYNE 1710
Query: 320 QMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSI--QEHC 376
++LKEK E+L+S + + + LE + ++ K E Q +SQ + QE
Sbjct: 1711 KLLKEKEALSEELNS--CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1768
Query: 377 SQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK 436
E T+Q + ++ +K L +T + LKQE+ +L K + ++ EI T
Sbjct: 1769 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH--KQLQNAGGKSWAPEIATHP 1826
Query: 437 DEL--IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQ 494
L +K ++++ + +N + +E + +T + T+ + ++R+ +S L
Sbjct: 1827 SGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1886
Query: 495 LEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
+ + E E + K RECD++++
Sbjct: 1887 KHQKHLNPSGTMNPTEQEKLSLK-------RECDQFQK 1917
Score = 51.2 bits (117), Expect = 1e-05
Identities = 136/635 (21%), Positives = 261/635 (41%), Gaps = 84/635 (13%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N ++T E + KN+I+QLQE L L ++ D + K ++
Sbjct: 1182 ELENSEETRTES----WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM 1237
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC-EALDN------EVYDKQMELSSL 224
E + E VS + ++ + +E + EAL+N EV+ Q EL +
Sbjct: 1238 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1297
Query: 225 EEVITVRDSLCKDLQE-KLTSNELT--LAETQQRLE-----MVKGHHALALEAN-ESIRR 275
EEV SL K E K+ + EL + Q ++E +V+ EA+ E++
Sbjct: 1298 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEI 1357
Query: 276 EYKIELEALKTKLDE------EKQAIISKCKVDQENL--------KTK-H-----NASIE 315
E + L L+E +I +CK + + L K K H + +I+
Sbjct: 1358 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ 1417
Query: 316 S------LKNQMLKEKCEAL-----EQLHSQLIIKEQEM-KAKLEQIEESASEKLKICEI 363
+ ++NQ++ E+ L + Q I E E+ K KL+++ E++ I
Sbjct: 1418 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1477
Query: 364 QFE-----ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
Q + E+ + ++ + T ++Q+++ L+Y + +NS L+ E+ L N +
Sbjct: 1478 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-NEE 1536
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
D +S K + + ++E+ +KT + E N AV+K ++ K + L + +
Sbjct: 1537 DSISNLK---LGTLNGSQEEMWQKTETVKQE----NAAVQKMVENLKKQISELKIKNQQL 1589
Query: 479 HVLTLRLRESDSE-LEQLEDQVQMLTS---------AKEVLENELTTYKNTLNNTVRECD 528
+ L + +S+ E+L++ Q LT LE E K L + C
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNLKEELERCK 1648
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR--ELG----TIKNELIE 582
LV+ L+++ + K T I++ L++ K+ +R +L I + L
Sbjct: 1649 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1708
Query: 583 DVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +LLK++ + ++ +++ K +L S L +Q A ++
Sbjct: 1709 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1768
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+N + + +L + +QE E L V
Sbjct: 1769 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEV 1803
>AF223939-1|AAK00630.1| 2073|Homo sapiens ninein isotype 3 protein.
Length = 2073
Score = 68.5 bits (160), Expect = 8e-11
Identities = 110/529 (20%), Positives = 220/529 (41%), Gaps = 38/529 (7%)
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
E E++C L ++V + Q EL + +R L E++ +N + E + L +
Sbjct: 522 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI-EPEHGLGSEE 580
Query: 261 GHHA-LALEAN---ESIRREYKIELEALKTKLDE-----EKQA--IISKCKVDQENLKTK 309
+ +++EA E ++ ++ ++ L+ +L++ EKQ + CK QEN+K +
Sbjct: 581 CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 640
Query: 310 HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERS 369
H +L+ Q+ K E E ++KE +A EE K +++ EE
Sbjct: 641 HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK-----KQLQVKLEEEK 695
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE-LNNLKNCKDELSTEKFNF 428
+QE Q + + + + Q+S +E + L ++ E+
Sbjct: 696 THLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 755
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT-RDIVHVLTLRLRE 487
+ E TL+ E + K + E + +L EK E N+ + + + +T R
Sbjct: 756 LVEKHTLEKEELRKEL-LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER--- 811
Query: 488 SDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
+S L+ LE + Q L +E E + ++ + +EC E +E L LK + +
Sbjct: 812 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 871
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
T+ E L+ KE + + +L++D+E L+ S +Q L +++ + +
Sbjct: 872 VLTQER-------EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSMLSDQILELK 924
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQ 666
+ S L +Q L RLE E+++ L+ ++ +
Sbjct: 925 SSHKRELREREEVLCQAGASEQLASQR---LERLEMEHDQ--ERQEMMSKLLAMENIHKA 979
Query: 667 ENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKV-GKENMQ 714
E A+ S+ I +L+ +++ Q S+L+ +V G+E ++
Sbjct: 980 TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVE 1028
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/484 (18%), Positives = 216/484 (44%), Gaps = 34/484 (7%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF-NEIDRKLSKL 167
++++ R++++T KQI D KNEIA+LQ A +++H+ +E ++K ++
Sbjct: 635 ENMKQRHENETHT-LEKQISDLKNEIAELQG----QAAVLKEAHHEATCRHEEEKKQLQV 689
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
++ H + + E + + S E++ E L + + + E+V
Sbjct: 690 KLEEEKTHLQEKLRLQHEMELKARLTQAQAS----FEREREGLQSSAWTE-------EKV 738
Query: 228 ITVRDSLCKDLQEKLTS--NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L + QE+LTS + TL + + R E+++ H E E + E ++
Sbjct: 739 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIE 798
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ + Q + +C+ ++L+ ++ ++ L+ Q +EK + E +L + E +
Sbjct: 799 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQECAEAQE 857
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
L++ + + + E ++ +EH + Q L Q++++L+ +++ Q S
Sbjct: 858 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR---NVSETQQS 914
Query: 406 DLKQELNNLKNC-KDELSTEKFNFIE--EIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L ++ LK+ K EL + + + L + +E+ + E+++ + + +
Sbjct: 915 MLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKLLAM 973
Query: 463 EKNKFETSLSVTRDIVHVLT--LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
E T + R+ + T RL+ E++Q + ML + +V+ E L
Sbjct: 974 ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVEGDGAL 1033
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR-ELGTIKNE 579
+ +++ ++ E ++L S L + H + ++ NV + + +++ + E G + +
Sbjct: 1034 -SLLQQGEQLLEENGDVLLS---LQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1089
Query: 580 LIED 583
+++
Sbjct: 1090 CLDE 1093
Score = 52.0 bits (119), Expect = 7e-06
Identities = 75/341 (21%), Positives = 148/341 (43%), Gaps = 24/341 (7%)
Query: 91 TLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATK 147
T+ + +L E + + + T E +++E + E +LQ+ IL+ T
Sbjct: 1456 TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT 1515
Query: 148 FRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK 205
+ S +N+ + ++R E+ AVQ E + I++++ + +L+
Sbjct: 1516 LNEEDSISNLKLGTLYWNSGRMRQKTETVKQENAAVQKM-VENLKKQISELKIKNQQLDL 1574
Query: 206 KCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK----LTSNELTLAETQQRLEMVKG 261
+ L + Q +L L + +T + LC+ +E L E ++ LE K
Sbjct: 1575 ENTELSQKNSQNQEKLQELNQRLT--EMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1632
Query: 262 HHALALEANESIRREYKIELEALKTK----LDE-EKQAIISKCKVDQENLKTKHNASIES 316
+ + + E+ E KI+ ++ + DE EK + +C D + + K + S+ S
Sbjct: 1633 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKIS-SVLS 1690
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSI--Q 373
++LKEK E+L+S + + + LE + ++ K E Q +SQ + Q
Sbjct: 1691 YNEKLLKEKEALSEELNS--CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQ 1748
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
E E T+Q + ++ +K L +T + LKQE+ +L
Sbjct: 1749 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSL 1789
Score = 48.4 bits (110), Expect = 9e-05
Identities = 82/385 (21%), Positives = 159/385 (41%), Gaps = 38/385 (9%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE-SIRR---E 276
L +++V+ ++ L DL + L +E V HHA NE ++R+ E
Sbjct: 373 LERVDQVVREKEKLRSDLDKAEKLKSLMASE-------VDDHHAAIERRNEYNLRKLDEE 425
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL 336
YK + ALK +L +E++ I+ + ++ L+ + + ++++ + +S+L
Sbjct: 426 YKERIAALKNELRKEREQILQ--QAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 483
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
E E+ E + L +F + + + + ++ E+ + L+ ++ EL+
Sbjct: 484 ---ENELLENAENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE 540
Query: 397 LDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
L+ Q L+ LKN E IE L E E N LN++
Sbjct: 541 LEEYRAQGRVLRLP---LKNSPSEEVEANSGGIEPEHGLGSE----------ECNPLNMS 587
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTT 515
+E + + E RDI LRL E + ++ E Q+ + + S K+ EN
Sbjct: 588 IEAELVIEQMKEQH---HRDI---CCLRL-ELEDKVRHYEKQLDETVVSCKKAQENMKQR 640
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
++N + ++ + K + + A L + H + + LQ V+ E +
Sbjct: 641 HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEEKTHLQ 699
Query: 576 IKNELIEDVELLKKESNSQIKFLRE 600
K L ++EL + + +Q F RE
Sbjct: 700 EKLRLQHEMELKARLTQAQASFERE 724
Score = 47.6 bits (108), Expect = 2e-04
Identities = 86/435 (19%), Positives = 185/435 (42%), Gaps = 49/435 (11%)
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ +++D+ AI + + + L ++ I +LKN++ KE+ + L+Q Q + EQE+
Sbjct: 400 MASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
Query: 344 -KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
KAK E E ++L + S++E+ + + ++ E + E LD ++
Sbjct: 460 EKAKTE--ENYIRDRLAL----------SLKENSRLENELLENAENVLAEKFGDLDPSSA 507
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAI 461
+ ++ L ++N E + +++ L+ EL E + L N E+
Sbjct: 508 EFFLQEERLTQMRN---EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVE 564
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM-LTSAKEVLENELTTYKNTL 520
E + + + L + + E++ +EQ+++Q + + LE+++ Y+ L
Sbjct: 565 ANSGGIEPEHGLGSEECNPLNMSI-EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQL 623
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
+ TV C + +E + +++ ++ +++ + ++ V KEA+ E E
Sbjct: 624 DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 683
Query: 581 IEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +++ +E + ++ EK R+ EM + L QA A R
Sbjct: 684 KKQLQVKLEEEKTHLQ------EKLRLQHEMEL-------------KARLTQAQASFERE 724
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPS 700
+ L EL Q E+LT V K + ++L+K+L +
Sbjct: 725 REGLQSSAWTEEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELLEKH------- 775
Query: 701 VLRKSLKVGKENMQT 715
++ L+ G+E M+T
Sbjct: 776 --QRELQEGREKMET 788
Score = 46.4 bits (105), Expect = 4e-04
Identities = 135/635 (21%), Positives = 258/635 (40%), Gaps = 84/635 (13%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N ++T E + KN+I+QLQE L L ++ D + K ++
Sbjct: 1165 ELENSEETRTES----WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM 1220
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC-EALDN------EVYDKQMELSSL 224
E + E VS + ++ + +E + EAL+N EV+ Q EL +
Sbjct: 1221 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1280
Query: 225 EEVITVRDSLCKDLQE-KLTSNELT--LAETQQRLE-----MVKGHHALALEAN-ESIRR 275
EEV SL K E K+ + EL + Q ++E +V+ EA+ E++
Sbjct: 1281 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEI 1340
Query: 276 EYKIELEALKTKLDE------EKQAIISKCKVDQENL--------KTK-H-----NASIE 315
E + L L+E +I +CK + + L K K H + +I+
Sbjct: 1341 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ 1400
Query: 316 S------LKNQMLKEKCEAL-----EQLHSQLIIKEQEM-KAKLEQIEESASEKLKICEI 363
+ ++NQ++ E+ L + Q I E E+ K KL+++ E++ I
Sbjct: 1401 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1460
Query: 364 QFE-----ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
Q + E+ + ++ + T ++Q+++ L+Y + +NS L+ E+ L N +
Sbjct: 1461 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-NEE 1519
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
D +S K + + + +KT + E N AV+K ++ K + L + +
Sbjct: 1520 DSISNLK---LGTLYWNSGRMRQKTETVKQE----NAAVQKMVENLKKQISELKIKNQQL 1572
Query: 479 HVLTLRLRESDSE-LEQLEDQVQMLTS---------AKEVLENELTTYKNTLNNTVRECD 528
+ L + +S+ E+L++ Q LT LE E K L + C
Sbjct: 1573 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNLKEELERCK 1631
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR--ELG----TIKNELIE 582
LV+ L+++ + K T I++ L++ K+ +R +L I + L
Sbjct: 1632 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1691
Query: 583 DVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +LLK++ + ++ +++ K +L S L +Q A ++
Sbjct: 1692 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1751
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+N + + +L + +QE E L V
Sbjct: 1752 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEV 1786
>AF223938-1|AAK00629.1| 2069|Homo sapiens ninein isotype 2 protein.
Length = 2069
Score = 68.5 bits (160), Expect = 8e-11
Identities = 110/529 (20%), Positives = 220/529 (41%), Gaps = 38/529 (7%)
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
E E++C L ++V + Q EL + +R L E++ +N + E + L +
Sbjct: 522 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI-EPEHGLGSEE 580
Query: 261 GHHA-LALEAN---ESIRREYKIELEALKTKLDE-----EKQA--IISKCKVDQENLKTK 309
+ +++EA E ++ ++ ++ L+ +L++ EKQ + CK QEN+K +
Sbjct: 581 CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 640
Query: 310 HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERS 369
H +L+ Q+ K E E ++KE +A EE K +++ EE
Sbjct: 641 HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK-----KQLQVKLEEEK 695
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE-LNNLKNCKDELSTEKFNF 428
+QE Q + + + + Q+S +E + L ++ E+
Sbjct: 696 THLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 755
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT-RDIVHVLTLRLRE 487
+ E TL+ E + K + E + +L EK E N+ + + + +T R
Sbjct: 756 LVEKHTLEKEELRKEL-LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER--- 811
Query: 488 SDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
+S L+ LE + Q L +E E + ++ + +EC E +E L LK + +
Sbjct: 812 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 871
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
T+ E L+ KE + + +L++D+E L+ S +Q L +++ + +
Sbjct: 872 VLTQER-------EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSMLSDQILELK 924
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQ 666
+ S L +Q L RLE E+++ L+ ++ +
Sbjct: 925 SSHKRELREREEVLCQAGASEQLASQR---LERLEMEHDQ--ERQEMMSKLLAMENIHKA 979
Query: 667 ENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKV-GKENMQ 714
E A+ S+ I +L+ +++ Q S+L+ +V G+E ++
Sbjct: 980 TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVE 1028
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/484 (18%), Positives = 216/484 (44%), Gaps = 34/484 (7%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF-NEIDRKLSKL 167
++++ R++++T KQI D KNEIA+LQ A +++H+ +E ++K ++
Sbjct: 635 ENMKQRHENETHT-LEKQISDLKNEIAELQG----QAAVLKEAHHEATCRHEEEKKQLQV 689
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
++ H + + E + + S E++ E L + + + E+V
Sbjct: 690 KLEEEKTHLQEKLRLQHEMELKARLTQAQAS----FEREREGLQSSAWTE-------EKV 738
Query: 228 ITVRDSLCKDLQEKLTS--NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L + QE+LTS + TL + + R E+++ H E E + E ++
Sbjct: 739 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIE 798
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ + Q + +C+ ++L+ ++ ++ L+ Q +EK + E +L + E +
Sbjct: 799 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQECAEAQE 857
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
L++ + + + E ++ +EH + Q L Q++++L+ +++ Q S
Sbjct: 858 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR---NVSETQQS 914
Query: 406 DLKQELNNLKNC-KDELSTEKFNFIE--EIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L ++ LK+ K EL + + + L + +E+ + E+++ + + +
Sbjct: 915 MLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKLLAM 973
Query: 463 EKNKFETSLSVTRDIVHVLT--LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
E T + R+ + T RL+ E++Q + ML + +V+ E L
Sbjct: 974 ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVEGDGAL 1033
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR-ELGTIKNE 579
+ +++ ++ E ++L S L + H + ++ NV + + +++ + E G + +
Sbjct: 1034 -SLLQQGEQLLEENGDVLLS---LQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1089
Query: 580 LIED 583
+++
Sbjct: 1090 CLDE 1093
Score = 53.6 bits (123), Expect = 2e-06
Identities = 95/461 (20%), Positives = 196/461 (42%), Gaps = 35/461 (7%)
Query: 91 TLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATK 147
T+ + +L E + + + T E +++E + E +LQ+ IL+ T
Sbjct: 1456 TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT 1515
Query: 148 FRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK 205
+ S +N+ + ++R E+ AVQ E + I++++ + +L+
Sbjct: 1516 LNEEDSISNLKLGTLYWNSGRMRQKTETVKQENAAVQKM-VENLKKQISELKIKNQQLDL 1574
Query: 206 KCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK----LTSNELTLAETQQRLEMVKG 261
+ L + Q +L L + +T + LC+ +E L E ++ LE K
Sbjct: 1575 ENTELSQKNSQNQEKLQELNQRLT--EMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1632
Query: 262 HHALALEANESIRREYKIELEALKTK----LDE-EKQAIISKCKVDQENLKTKHNASIES 316
+ + + E+ E KI+ ++ + DE EK + +C D + + K + S+ S
Sbjct: 1633 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKIS-SVLS 1690
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSI--Q 373
++LKEK E+L+S + + + LE + ++ K E Q +SQ + Q
Sbjct: 1691 YNEKLLKEKEALSEELNS--CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQ 1748
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
E E T+Q + ++ +K L +T + LKQE+ +L K + ++ EI
Sbjct: 1749 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH--KQLQNAGGKSWAPEIA 1806
Query: 434 TLKDEL--IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
T L +K ++++ + +N + +E + +T + T+ + ++R+ +S
Sbjct: 1807 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERSQTMVQNTKAELTHSREKVRQLESN 1866
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
L + + E E + K RECD++++
Sbjct: 1867 LLPKHQKHLNPSGTMNPTEQEKLSLK-------RECDQFQK 1900
Score = 48.4 bits (110), Expect = 9e-05
Identities = 82/385 (21%), Positives = 159/385 (41%), Gaps = 38/385 (9%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE-SIRR---E 276
L +++V+ ++ L DL + L +E V HHA NE ++R+ E
Sbjct: 373 LERVDQVVREKEKLRSDLDKAEKLKSLMASE-------VDDHHAAIERRNEYNLRKLDEE 425
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL 336
YK + ALK +L +E++ I+ + ++ L+ + + ++++ + +S+L
Sbjct: 426 YKERIAALKNELRKEREQILQ--QAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 483
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
E E+ E + L +F + + + + ++ E+ + L+ ++ EL+
Sbjct: 484 ---ENELLENAENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE 540
Query: 397 LDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
L+ Q L+ LKN E IE L E E N LN++
Sbjct: 541 LEEYRAQGRVLRLP---LKNSPSEEVEANSGGIEPEHGLGSE----------ECNPLNMS 587
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTT 515
+E + + E RDI LRL E + ++ E Q+ + + S K+ EN
Sbjct: 588 IEAELVIEQMKEQH---HRDI---CCLRL-ELEDKVRHYEKQLDETVVSCKKAQENMKQR 640
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
++N + ++ + K + + A L + H + + LQ V+ E +
Sbjct: 641 HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEEKTHLQ 699
Query: 576 IKNELIEDVELLKKESNSQIKFLRE 600
K L ++EL + + +Q F RE
Sbjct: 700 EKLRLQHEMELKARLTQAQASFERE 724
Score = 47.6 bits (108), Expect = 2e-04
Identities = 86/435 (19%), Positives = 185/435 (42%), Gaps = 49/435 (11%)
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ +++D+ AI + + + L ++ I +LKN++ KE+ + L+Q Q + EQE+
Sbjct: 400 MASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
Query: 344 -KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
KAK E E ++L + S++E+ + + ++ E + E LD ++
Sbjct: 460 EKAKTE--ENYIRDRLAL----------SLKENSRLENELLENAENVLAEKFGDLDPSSA 507
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAI 461
+ ++ L ++N E + +++ L+ EL E + L N E+
Sbjct: 508 EFFLQEERLTQMRN---EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVE 564
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM-LTSAKEVLENELTTYKNTL 520
E + + + L + + E++ +EQ+++Q + + LE+++ Y+ L
Sbjct: 565 ANSGGIEPEHGLGSEECNPLNMSI-EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQL 623
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
+ TV C + +E + +++ ++ +++ + ++ V KEA+ E E
Sbjct: 624 DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 683
Query: 581 IEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +++ +E + ++ EK R+ EM + L QA A R
Sbjct: 684 KKQLQVKLEEEKTHLQ------EKLRLQHEMEL-------------KARLTQAQASFERE 724
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPS 700
+ L EL Q E+LT V K + ++L+K+L +
Sbjct: 725 REGLQSSAWTEEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELLEKH------- 775
Query: 701 VLRKSLKVGKENMQT 715
++ L+ G+E M+T
Sbjct: 776 --QRELQEGREKMET 788
Score = 46.4 bits (105), Expect = 4e-04
Identities = 135/635 (21%), Positives = 258/635 (40%), Gaps = 84/635 (13%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N ++T E + KN+I+QLQE L L ++ D + K ++
Sbjct: 1165 ELENSEETRTES----WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM 1220
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC-EALDN------EVYDKQMELSSL 224
E + E VS + ++ + +E + EAL+N EV+ Q EL +
Sbjct: 1221 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1280
Query: 225 EEVITVRDSLCKDLQE-KLTSNELT--LAETQQRLE-----MVKGHHALALEAN-ESIRR 275
EEV SL K E K+ + EL + Q ++E +V+ EA+ E++
Sbjct: 1281 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEI 1340
Query: 276 EYKIELEALKTKLDE------EKQAIISKCKVDQENL--------KTK-H-----NASIE 315
E + L L+E +I +CK + + L K K H + +I+
Sbjct: 1341 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ 1400
Query: 316 S------LKNQMLKEKCEAL-----EQLHSQLIIKEQEM-KAKLEQIEESASEKLKICEI 363
+ ++NQ++ E+ L + Q I E E+ K KL+++ E++ I
Sbjct: 1401 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1460
Query: 364 QFE-----ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
Q + E+ + ++ + T ++Q+++ L+Y + +NS L+ E+ L N +
Sbjct: 1461 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-NEE 1519
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
D +S K + + + +KT + E N AV+K ++ K + L + +
Sbjct: 1520 DSISNLK---LGTLYWNSGRMRQKTETVKQE----NAAVQKMVENLKKQISELKIKNQQL 1572
Query: 479 HVLTLRLRESDSE-LEQLEDQVQMLTS---------AKEVLENELTTYKNTLNNTVRECD 528
+ L + +S+ E+L++ Q LT LE E K L + C
Sbjct: 1573 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNLKEELERCK 1631
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR--ELG----TIKNELIE 582
LV+ L+++ + K T I++ L++ K+ +R +L I + L
Sbjct: 1632 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1691
Query: 583 DVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +LLK++ + ++ +++ K +L S L +Q A ++
Sbjct: 1692 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1751
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+N + + +L + +QE E L V
Sbjct: 1752 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEV 1786
>AF223937-1|AAK00628.1| 2029|Homo sapiens ninein isotype 1 protein.
Length = 2029
Score = 68.5 bits (160), Expect = 8e-11
Identities = 110/529 (20%), Positives = 220/529 (41%), Gaps = 38/529 (7%)
Query: 202 ELEKKCEALDNEVYDKQMELSSLE-EVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
E E++C L ++V + Q EL + +R L E++ +N + E + L +
Sbjct: 522 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI-EPEHGLGSEE 580
Query: 261 GHHA-LALEAN---ESIRREYKIELEALKTKLDE-----EKQA--IISKCKVDQENLKTK 309
+ +++EA E ++ ++ ++ L+ +L++ EKQ + CK QEN+K +
Sbjct: 581 CNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQR 640
Query: 310 HNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERS 369
H +L+ Q+ K E E ++KE +A EE K +++ EE
Sbjct: 641 HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEK-----KQLQVKLEEEK 695
Query: 370 QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQE-LNNLKNCKDELSTEKFNF 428
+QE Q + + + + Q+S +E + L ++ E+
Sbjct: 696 THLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTS 755
Query: 429 IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVT-RDIVHVLTLRLRE 487
+ E TL+ E + K + E + +L EK E N+ + + + +T R
Sbjct: 756 LVEKHTLEKEELRKEL-LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER--- 811
Query: 488 SDSELEQLEDQV-QMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTK 546
+S L+ LE + Q L +E E + ++ + +EC E +E L LK + +
Sbjct: 812 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 871
Query: 547 EHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
T+ E L+ KE + + +L++D+E L+ S +Q L +++ + +
Sbjct: 872 VLTQER-------EMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSMLSDQILELK 924
Query: 607 VLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQ 666
+ S L +Q L RLE E+++ L+ ++ +
Sbjct: 925 SSHKRELREREEVLCQAGASEQLASQR---LERLEMEHDQ--ERQEMMSKLLAMENIHKA 979
Query: 667 ENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPSVLRKSLKV-GKENMQ 714
E A+ S+ I +L+ +++ Q S+L+ +V G+E ++
Sbjct: 980 TCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVE 1028
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/484 (18%), Positives = 216/484 (44%), Gaps = 34/484 (7%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDF-NEIDRKLSKL 167
++++ R++++T KQI D KNEIA+LQ A +++H+ +E ++K ++
Sbjct: 635 ENMKQRHENETHT-LEKQISDLKNEIAELQG----QAAVLKEAHHEATCRHEEEKKQLQV 689
Query: 168 RINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEV 227
++ H + + E + + S E++ E L + + + E+V
Sbjct: 690 KLEEEKTHLQEKLRLQHEMELKARLTQAQAS----FEREREGLQSSAWTE-------EKV 738
Query: 228 ITVRDSLCKDLQEKLTS--NELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALK 285
+ L + QE+LTS + TL + + R E+++ H E E + E ++
Sbjct: 739 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIE 798
Query: 286 TKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKA 345
+ + Q + +C+ ++L+ ++ ++ L+ Q +EK + E +L + E +
Sbjct: 799 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQ-WEFEKDELTQECAEAQE 857
Query: 346 KLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
L++ + + + E ++ +EH + Q L Q++++L+ +++ Q S
Sbjct: 858 LLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLR---NVSETQQS 914
Query: 406 DLKQELNNLKNC-KDELSTEKFNFIE--EIKTLKDELIEKTINYENEKNKLNLAVEKAIK 462
L ++ LK+ K EL + + + L + +E+ + E+++ + + +
Sbjct: 915 MLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLER-LEMEHDQERQEMMSKLLAM 973
Query: 463 EKNKFETSLSVTRDIVHVLT--LRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTL 520
E T + R+ + T RL+ E++Q + ML + +V+ E L
Sbjct: 974 ENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVEGDGAL 1033
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR-ELGTIKNE 579
+ +++ ++ E ++L S L + H + ++ NV + + +++ + E G + +
Sbjct: 1034 -SLLQQGEQLLEENGDVLLS---LQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSS 1089
Query: 580 LIED 583
+++
Sbjct: 1090 CLDE 1093
Score = 53.6 bits (123), Expect = 2e-06
Identities = 95/461 (20%), Positives = 196/461 (42%), Gaps = 35/461 (7%)
Query: 91 TLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQE---ILKELATK 147
T+ + +L E + + + T E +++E + E +LQ+ IL+ T
Sbjct: 1456 TILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITT 1515
Query: 148 FRQ--SHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEK 205
+ S +N+ + ++R E+ AVQ E + I++++ + +L+
Sbjct: 1516 LNEEDSISNLKLGTLYWNSGRMRQKTETVKQENAAVQKM-VENLKKQISELKIKNQQLDL 1574
Query: 206 KCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK----LTSNELTLAETQQRLEMVKG 261
+ L + Q +L L + +T + LC+ +E L E ++ LE K
Sbjct: 1575 ENTELSQKNSQNQEKLQELNQRLT--EMLCQKEKEPGNSALEEREQEKFNLKEELERCKV 1632
Query: 262 HHALALEANESIRREYKIELEALKTK----LDE-EKQAIISKCKVDQENLKTKHNASIES 316
+ + + E+ E KI+ ++ + DE EK + +C D + + K + S+ S
Sbjct: 1633 QSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKIS-SVLS 1690
Query: 317 LKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEE-RSQSI--Q 373
++LKEK E+L+S + + + LE + ++ K E Q +SQ + Q
Sbjct: 1691 YNEKLLKEKEALSEELNS--CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQ 1748
Query: 374 EHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
E E T+Q + ++ +K L +T + LKQE+ +L K + ++ EI
Sbjct: 1749 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH--KQLQNAGGKSWAPEIA 1806
Query: 434 TLKDEL--IEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSE 491
T L +K ++++ + +N + +E + +T + T+ + ++R+ +S
Sbjct: 1807 THPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERSQTMVQNTKAELTHSREKVRQLESN 1866
Query: 492 LEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
L + + E E + K RECD++++
Sbjct: 1867 LLPKHQKHLNPSGTMNPTEQEKLSLK-------RECDQFQK 1900
Score = 48.4 bits (110), Expect = 9e-05
Identities = 82/385 (21%), Positives = 159/385 (41%), Gaps = 38/385 (9%)
Query: 221 LSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANE-SIRR---E 276
L +++V+ ++ L DL + L +E V HHA NE ++R+ E
Sbjct: 373 LERVDQVVREKEKLRSDLDKAEKLKSLMASE-------VDDHHAAIERRNEYNLRKLDEE 425
Query: 277 YKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL 336
YK + ALK +L +E++ I+ + ++ L+ + + ++++ + +S+L
Sbjct: 426 YKERIAALKNELRKEREQILQ--QAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRL 483
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
E E+ E + L +F + + + + ++ E+ + L+ ++ EL+
Sbjct: 484 ---ENELLENAENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE 540
Query: 397 LDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLA 456
L+ Q L+ LKN E IE L E E N LN++
Sbjct: 541 LEEYRAQGRVLRLP---LKNSPSEEVEANSGGIEPEHGLGSE----------ECNPLNMS 587
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQV-QMLTSAKEVLENELTT 515
+E + + E RDI LRL E + ++ E Q+ + + S K+ EN
Sbjct: 588 IEAELVIEQMKEQH---HRDI---CCLRL-ELEDKVRHYEKQLDETVVSCKKAQENMKQR 640
Query: 516 YKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGT 575
++N + ++ + K + + A L + H + + LQ V+ E +
Sbjct: 641 HENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQ-VKLEEEKTHLQ 699
Query: 576 IKNELIEDVELLKKESNSQIKFLRE 600
K L ++EL + + +Q F RE
Sbjct: 700 EKLRLQHEMELKARLTQAQASFERE 724
Score = 47.6 bits (108), Expect = 2e-04
Identities = 86/435 (19%), Positives = 185/435 (42%), Gaps = 49/435 (11%)
Query: 284 LKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEM 343
+ +++D+ AI + + + L ++ I +LKN++ KE+ + L+Q Q + EQE+
Sbjct: 400 MASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEI 459
Query: 344 -KAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
KAK E E ++L + S++E+ + + ++ E + E LD ++
Sbjct: 460 EKAKTE--ENYIRDRLAL----------SLKENSRLENELLENAENVLAEKFGDLDPSSA 507
Query: 403 QNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL-NLAVEKAI 461
+ ++ L ++N E + +++ L+ EL E + L N E+
Sbjct: 508 EFFLQEERLTQMRN---EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVE 564
Query: 462 KEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQM-LTSAKEVLENELTTYKNTL 520
E + + + L + + E++ +EQ+++Q + + LE+++ Y+ L
Sbjct: 565 ANSGGIEPEHGLGSEECNPLNMSI-EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQL 623
Query: 521 NNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL 580
+ TV C + +E + +++ ++ +++ + ++ V KEA+ E E
Sbjct: 624 DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 683
Query: 581 IEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +++ +E + ++ EK R+ EM + L QA A R
Sbjct: 684 KKQLQVKLEEEKTHLQ------EKLRLQHEMEL-------------KARLTQAQASFERE 724
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTPKSPS 700
+ L EL Q E+LT V K + ++L+K+L +
Sbjct: 725 REGLQSSAWTEEKVRGLTQELEQFHQ--EQLTSLVEKHTLEKEELRKELLEKH------- 775
Query: 701 VLRKSLKVGKENMQT 715
++ L+ G+E M+T
Sbjct: 776 --QRELQEGREKMET 788
Score = 46.4 bits (105), Expect = 4e-04
Identities = 135/635 (21%), Positives = 258/635 (40%), Gaps = 84/635 (13%)
Query: 112 EIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINN 171
E+ N ++T E + KN+I+QLQE L L ++ D + K ++
Sbjct: 1165 ELENSEETRTES----WELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKM 1220
Query: 172 TNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKC-EALDN------EVYDKQMELSSL 224
E + E VS + ++ + +E + EAL+N EV+ Q EL +
Sbjct: 1221 LERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM 1280
Query: 225 EEVITVRDSLCKDLQE-KLTSNELT--LAETQQRLE-----MVKGHHALALEAN-ESIRR 275
EEV SL K E K+ + EL + Q ++E +V+ EA+ E++
Sbjct: 1281 EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEI 1340
Query: 276 EYKIELEALKTKLDE------EKQAIISKCKVDQENL--------KTK-H-----NASIE 315
E + L L+E +I +CK + + L K K H + +I+
Sbjct: 1341 EPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQ 1400
Query: 316 S------LKNQMLKEKCEAL-----EQLHSQLIIKEQEM-KAKLEQIEESASEKLKICEI 363
+ ++NQ++ E+ L + Q I E E+ K KL+++ E++ I
Sbjct: 1401 THQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVK 1460
Query: 364 QFE-----ERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCK 418
Q + E+ + ++ + T ++Q+++ L+Y + +NS L+ E+ L N +
Sbjct: 1461 QKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL-NEE 1519
Query: 419 DELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIV 478
D +S K + + + +KT + E N AV+K ++ K + L + +
Sbjct: 1520 DSISNLK---LGTLYWNSGRMRQKTETVKQE----NAAVQKMVENLKKQISELKIKNQQL 1572
Query: 479 HVLTLRLRESDSE-LEQLEDQVQMLTS---------AKEVLENELTTYKNTLNNTVRECD 528
+ L + +S+ E+L++ Q LT LE E K L + C
Sbjct: 1573 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALE-EREQEKFNLKEELERCK 1631
Query: 529 EYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYR--ELG----TIKNELIE 582
LV+ L+++ + K T I++ L++ K+ +R +L I + L
Sbjct: 1632 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1691
Query: 583 DVELLKKES--NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRL 640
+ +LLK++ + ++ +++ K +L S L +Q A ++
Sbjct: 1692 NEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKV 1751
Query: 641 ENENERYXXXXXXXXSLVVELSLLRQENEELTMTV 675
+N + + +L + +QE E L V
Sbjct: 1752 QNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEV 1786
>AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein.
Length = 4547
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1767
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1886
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1947 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2001
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2002 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2057
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2058 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1822 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1882 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1935
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1936 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 1991
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 1992 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2153
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2209
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2210 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2326 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 717 SPLRER 722
S ER
Sbjct: 2379 SAEAER 2384
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1948
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2069 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2125
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2237
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2238 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2290 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2339
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2340 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2393
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2394 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1304 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1418
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1419 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERR 1613
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2509
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2570 QEELQQLEQQ 2579
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2191
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2423
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2428
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2489 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2539
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTL 2626
>AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein.
Length = 4551
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1771
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1831
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1890
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1891 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1951 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2005
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2006 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2061
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2062 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1826 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1885
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1886 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1939
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1940 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 1995
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 1996 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2045
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2106 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2157
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2213
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2214 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2269
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2330 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 717 SPLRER 722
S ER
Sbjct: 2383 SAEAER 2388
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1952
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2073 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2129
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2241
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2242 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2294 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2343
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2344 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2397
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2398 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2483
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1308 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1422
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1423 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERR 1617
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2274
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2334
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2335 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2513
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2574 QEELQQLEQQ 2583
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2195
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2427
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2432
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2433 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2492
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2493 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2543
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2604 LLEEQHRAALAHSEEVTASQVAATKTL 2630
>AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein.
Length = 4547
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1767
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1886
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1947 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2001
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2002 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2057
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2058 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1822 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1882 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1935
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1936 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 1991
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 1992 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2153
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2209
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2210 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2326 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 717 SPLRER 722
S ER
Sbjct: 2379 SAEAER 2384
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1948
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2069 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2125
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2237
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2238 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2290 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2339
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2340 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2393
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2394 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1304 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1418
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1419 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERR 1613
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2509
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2570 QEELQQLEQQ 2579
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2191
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2423
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2428
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2489 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2539
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTL 2626
>AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein.
Length = 4515
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1735
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1795
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1854
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1855 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1915 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 1969
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 1970 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2025
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2026 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1790 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1849
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1850 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1903
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1904 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 1959
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 1960 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2070 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2121
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2177
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2178 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2233
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2294 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 717 SPLRER 722
S ER
Sbjct: 2347 SAEAER 2352
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1916
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2037 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2093
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2205
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2206 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2258 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2307
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2308 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2361
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2362 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2447
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1272 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1386
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1387 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1557
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERR 1581
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2238
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2298
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2299 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2477
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2538 QEELQQLEQQ 2547
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2159
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2391
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2544
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2396
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2397 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2456
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2457 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2507
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2568 LLEEQHRAALAHSEEVTASQVAATKTL 2594
>AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein.
Length = 4684
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1904
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1964
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 2023
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 2024 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 2084 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2138
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2139 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2194
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2195 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1959 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 2018
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 2019 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 2072
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 2073 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 2128
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 2129 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2178
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2239 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2290
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2346
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2347 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2402
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2463 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 717 SPLRER 722
S ER
Sbjct: 2516 SAEAER 2521
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 2085
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2206 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2262
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2374
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2375 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2427 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2476
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2477 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2530
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2531 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2616
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1441 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1555
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1556 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERR 1750
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2407
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2468 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2646
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2707 QEELQQLEQQ 2716
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2328
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2560
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2713
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2565
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2625
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2626 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2676
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2737 LLEEQHRAALAHSEEVTASQVAATKTL 2763
>AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein.
Length = 4525
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1745
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1805
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1864
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1865 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1925 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 1979
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 1980 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2035
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2036 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1800 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1859
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1860 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1913
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1914 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 1969
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 1970 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2019
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2080 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2131
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2187
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2188 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2243
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2304 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 717 SPLRER 722
S ER
Sbjct: 2357 SAEAER 2362
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1926
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2047 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2103
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2215
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2216 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2268 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2317
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2318 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2371
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2372 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2457
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1282 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1396
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1397 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1567
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERR 1591
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2248
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2309 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2487
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2548 QEELQQLEQQ 2557
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2169
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2401
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2554
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2406
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2407 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2466
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2467 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2517
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2578 LLEEQHRAALAHSEEVTASQVAATKTL 2604
>AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein.
Length = 4533
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1753
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1813
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1872
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1873 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1933 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 1987
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 1988 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2043
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2044 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1808 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1867
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1868 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1921
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1922 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 1977
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 1978 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2027
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2088 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2139
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2195
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2196 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2251
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2312 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 717 SPLRER 722
S ER
Sbjct: 2365 SAEAER 2370
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1934
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2055 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2111
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2223
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2224 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2276 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2325
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2326 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2379
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2380 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2465
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1290 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1404
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1405 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1575
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERR 1599
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2197 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2256
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2316
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2317 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2495
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2556 QEELQQLEQQ 2565
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2177
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2409
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2469
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2562
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2414
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2415 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2474
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2475 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2525
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2586 LLEEQHRAALAHSEEVTASQVAATKTL 2612
>AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein.
Length = 4574
Score = 68.1 bits (159), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1794
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1913
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1974 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2028
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2029 RQRKAALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2084
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2085 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Score = 62.5 bits (145), Expect = 5e-09
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 54/606 (8%)
Query: 128 EDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAE 187
ED + A+ + +L E ++ EI K + E A Q E
Sbjct: 1849 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1908
Query: 188 KVSAMIN-DMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+ +A D+ R+ +L K A D+E+ ++Q L +E+ + R + +++ S E
Sbjct: 1909 EQAAQHKADIEERLAQLRK---ASDSEL-ERQKGL--VEDTLRQRRQVEEEILALKASFE 1962
Query: 247 LTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTK---LDEEKQAIISKCKVDQ 303
A + LE+ G + A +++R + + ELEA + + +EE++ ++ +V Q
Sbjct: 1963 KAAAGKAE-LELELGR--IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV-Q 2018
Query: 304 ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI 363
++L + A+ +++ ALE++ +L K +E + E+ E+ ++ +L++ +
Sbjct: 2019 KSLAAEEEAA---------RQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQE 2068
Query: 364 QFEERSQSIQE-HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELS 422
++R Q+ ++ H ++ Q L+Q +++ + LD + ++ + + +
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2128
Query: 423 TEKFNF---IEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVH 479
E +EE + LK E+ + + A EK KE + + R
Sbjct: 2129 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQE----AARRAQAE 2180
Query: 480 VLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNIL 538
LR +++ D+E+E+ + + K +E ELTT + L T D K L L
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKNLLDEEL 2236
Query: 539 KSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKESNSQIKF 597
+ L E T + E L +V + EL +K + E+ L+ ++ ++ +F
Sbjct: 2237 Q---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 598 LREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXXXSL 657
L+EE EK + + E ++ A + E + L
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 658 VVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGKENMQTI 716
E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ ++ +
Sbjct: 2353 KAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 717 SPLRER 722
S ER
Sbjct: 2406 SAEAER 2411
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 265/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1975
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ + ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2096 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--LKQSAEEQA 2152
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2264
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2265 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2317 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2366
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2367 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2420
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2421 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2506
Score = 58.8 bits (136), Expect = 6e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1331 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1445
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1446 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERR 1640
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2297
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2358 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2536
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2597 QEELQQLEQQ 2606
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2218
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2450
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2455
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2515
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2516 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2566
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2627 LLEEQHRAALAHSEEVTASQVAATKTL 2653
>X63105-1|CAA44819.1| 726|Homo sapiens Tpr protein.
Length = 726
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
>X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (
544 AA) protein.
Length = 543
Score = 67.7 bits (158), Expect = 1e-10
Identities = 96/451 (21%), Positives = 191/451 (42%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + +TI E K + + E +L
Sbjct: 90 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKMEL 148
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 149 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 208
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ + ++KK E NE+ +++LS + K LQ L ++
Sbjct: 209 LDAETRS-RNEALRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 264
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ D+E ++T
Sbjct: 265 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLADRELIET 317
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + ++ SQL + +E + EE A + + + EE
Sbjct: 318 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 377
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + ++EL
Sbjct: 378 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 436
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E+++ NL +D+V L
Sbjct: 437 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR----------------LQDLVDKLQ 480
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 481 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 511
Score = 66.9 bits (156), Expect = 2e-10
Identities = 90/434 (20%), Positives = 186/434 (42%), Gaps = 26/434 (5%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
++ + + ++ LEK L NE+ D +++ D ++ + L +
Sbjct: 6 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 65
Query: 247 LTLAETQQRLEMV-KGHHALALEANESIRREYKIELEALKTKLDEEK--QAIISKCKVDQ 303
E+Q LE K +L+ E + ++ Y+ LE L+T E K Q IS +Q
Sbjct: 66 QKYEESQSELESSQKEARSLSTELFK-LKNAYEESLEHLETFKRENKNLQEEISDL-TEQ 123
Query: 304 ENLKTKHNASIESLKNQMLKEKCE---ALEQLHSQLIIKEQE-MKAKLEQIEESASEKLK 359
K +E ++ Q+ EK E ALE+ + L +E + ++A+LE + A + K
Sbjct: 124 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 183
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
+ E + EE Q+ + H + L+ E + L + DL + L + +
Sbjct: 184 LAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA-N 241
Query: 420 ELSTEKFNFIEEIKTL-KDELIEKTINYE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
++ E ++ +++L KD I+ N+ K N+A+ + + N + L R +
Sbjct: 242 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE--RRNNLLQAELEELRAV 299
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSA-------KEVLENELTTYKNTLNNTVRECDEY 530
V + +D EL + ++VQ+L S K+ ++ +L+ + + V+EC
Sbjct: 300 VEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 359
Query: 531 KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+E + A + +E + + + L+ ++K + + +++ L E ++ K
Sbjct: 360 EEKAKKAITDAAMMAEELKKEQDTSA----HLERMKKNMEQTIKDLQHRLDEAEQIALKG 415
Query: 591 SNSQIKFLREEVEK 604
Q++ L V +
Sbjct: 416 GKKQLQKLEARVRE 429
Score = 54.4 bits (125), Expect = 1e-06
Identities = 64/321 (19%), Positives = 146/321 (45%), Gaps = 24/321 (7%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
D ++ ++ E +K+ ++L + + D Q++L ++ + D L +++
Sbjct: 229 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL---DDAVRANDDLKENIAIVERR 285
Query: 245 NELTLAETQQ-RLEMVKGHHALALEANESIRREYKIEL-EALKTKLDEEKQAIISKCKVD 302
N L AE ++ R + + + L E I +++L + T L +K+ K D
Sbjct: 286 NNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKK----KMDAD 341
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQ-LHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+T+ +++ +N K K + + ++ + KEQ+ A LE+++++ + +K
Sbjct: 342 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 401
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL 421
+ + +E Q + +Q +Q LE ++EL+ L+ +N++ + + + EL
Sbjct: 402 QHRLDEAEQIALKGGKKQ---LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL 458
Query: 422 STEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
+ + + + L+D L++K + K+ +A + + + T+LS R + H
Sbjct: 459 TYQTEEDRKNLLRLQD-LVDKL------QLKVKAYKRQAEEAEEQANTNLSKFRKVQH-- 509
Query: 482 TLRLRESDSELEQLEDQVQML 502
L E++ + E QV L
Sbjct: 510 --ELDEAEERADIAESQVNKL 528
Score = 50.0 bits (114), Expect = 3e-05
Identities = 63/341 (18%), Positives = 148/341 (43%), Gaps = 18/341 (5%)
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
EE +++ CS EKT L+ EI++L ++ +N + L ++ N D++ E
Sbjct: 9 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF----DKILAEW 64
Query: 426 FNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL 485
EE ++ + ++ + E KL A E++++ F+ ++ + LT +L
Sbjct: 65 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 124
Query: 486 RESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN----TVRECDEYKEALVNILKSK 541
S + +LE + L + K L++ L + +L + +R E+ + I +
Sbjct: 125 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 184
Query: 542 AALTKEHTRIMEHNVTLIESLQ---NVEKEAYRELGTIKNEL---IEDVELLKKESNSQI 595
A +E + +++ +++SLQ + E + E +K ++ + ++E+ +N
Sbjct: 185 AEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMA 244
Query: 596 KFLREEVEKKRVLCE--MXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXX 653
+++V+ + L + + + + +L + E E R
Sbjct: 245 AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 304
Query: 654 XXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK-DLEQSQ 693
+ + L+ + +E + + ++ +S+I++ KK D + SQ
Sbjct: 305 RSRKLADRELI-ETSERVQLLHSQNTSLINQKKKMDADLSQ 344
>U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein.
Length = 2363
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 67.3 bits (157), Expect = 2e-10
Identities = 96/497 (19%), Positives = 205/497 (41%), Gaps = 25/497 (5%)
Query: 181 VQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQE 240
++ T+A + A + ++ I E KK +A + ++ ++Q+E L+E +T S +
Sbjct: 660 IESTEAIEAKAALKQLQE-IFENYKKEKAENEKIQNEQLE--KLQEQVTDLRSQNTKIST 716
Query: 241 KLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAI--ISK 298
+L Q +E + E N+ + + + + + T + + A ++
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV 776
Query: 299 CKVDQENLKT-KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEK 357
++ ENLK K + ++ +E A ++ + L+ Q ++ LE+ E ++
Sbjct: 777 AEIRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQR 836
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
L + + ++ S +K ++ ++ L LD+ Q D K++L+ N
Sbjct: 837 LS-------SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDV---QLLDTKRQLDTETNL 886
Query: 418 KDELSTEKF--NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEK-NKFETSLSVT 474
L+T++ N +EI TLK L + ++ ++ + + KE + + L T
Sbjct: 887 --HLNTKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQT 944
Query: 475 RDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEAL 534
+ V+ L RL+ S S +EQ + M+TS +E L E + N E E
Sbjct: 945 EEQVNDLKERLKTSTSNVEQYQ---AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 535 VNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQ 594
+ K + KE + + IES++ E + L +++NE+ E ++ +++
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 595 IKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXXX 654
+ R+ E+ ++ E L A A +S++ + +
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA-AKEQVSKMASVRQHLEETTQKA 1120
Query: 655 XSLVVELSLLRQENEEL 671
S ++E +E E +
Sbjct: 1121 ESQLLECKASWEERERM 1137
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
Score = 64.9 bits (151), Expect = 1e-09
Identities = 90/470 (19%), Positives = 199/470 (42%), Gaps = 28/470 (5%)
Query: 79 KITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQ 138
K++ +S+K+ + P N L ++ Q Q +EI K+I + + E+AQ++
Sbjct: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR----FIRREKEIAETRFEVAQVE 1220
Query: 139 EILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRS 198
+ + + + ++ + K+++ ++ T+ V N M
Sbjct: 1221 SLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM-- 1278
Query: 199 RIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEK--LTSNELTLAETQQRL 256
L ++ E L+ ++ Q ++ LE I +L EK + E L E +
Sbjct: 1279 ----LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKR 1334
Query: 257 EMVKGHHALALEANESIRREYKIELEA-LKTKLDEEKQAIISKCKVD--QENLKTKHNAS 313
+ H ++ + + K+ E + TK ++ I + K + + N +N +
Sbjct: 1335 WKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394
Query: 314 -IESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEE--SASEKLKICEIQFEERSQ 370
I+SLK + K + E E + L K +++ K++ I + + K + + +
Sbjct: 1395 LIQSLKEDLNKVRTEK-ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQD 1453
Query: 371 SIQEHCSQQ--EKTIQYLE-QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+ E +Q + Q++ QE++ELK TL+ ++ L+ ++ NL+ E TE N
Sbjct: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARN 1513
Query: 428 FIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRD-IVHVLTLRLR 486
E+ L+ EL + ++ + ++ +++ K ++ + I H+ ++
Sbjct: 1514 LQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK-D 1572
Query: 487 ESDSELEQLEDQVQMLTSAKEVLENELTT----YKNTLNNTVRECDEYKE 532
+ E E+L+ + L K+ L+ +T Y+ ++ RE E++E
Sbjct: 1573 QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 60.9 bits (141), Expect = 2e-08
Identities = 104/493 (21%), Positives = 212/493 (43%), Gaps = 59/493 (11%)
Query: 162 RKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIEL-------EKKCEALDNEV 214
++L ++ N E+ +Q EK+ + D+RS+ ++ K+ E L + V
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 215 YDKQMELSSL--------------EEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVK 260
+ E++SL E++I + EKL E+ ++ EM+K
Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEIRAENLKKEKEMLK 792
Query: 261 GHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQ 320
+ ES+ E + + L T L + Q I+ + + + K + ++ IE L+++
Sbjct: 793 LSEVRLSQQRESLLAEQRGQ-NLLLTNL-QTIQGILERSETE---TKQRLSSQIEKLEHE 847
Query: 321 M--LKEKCE-ALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEI--QFEERSQSIQEH 375
+ LK+K E +EQ H+ + ++ Q++ + L E+ ++ +++ H
Sbjct: 848 ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKRH 907
Query: 376 CSQQEKTI--QYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
S E + Q ++ K + ++ S L+Q + + K+ L T N +E+ +
Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN-VEQYQ 966
Query: 434 TLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSL-----SVTRDIVHVLTLRLRE 487
+ L E+++N E + ++ +E +KE +F+T L V ++ + + R
Sbjct: 967 AMVTSL-EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRA 1025
Query: 488 SDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN---TVRECDEYKEALVNILKSKAAL 544
+S +QL + + L+S + ++ L L+N R+C E + V A
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVE------AQ 1079
Query: 545 TKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-----DVELL--KKESNSQIKF 597
K +M H +E+LQ KE ++ +++ L E + +LL K + +
Sbjct: 1080 NKYERELMLHAAD-VEALQ-AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
Query: 598 LREEVEKKRVLCE 610
L++EV K CE
Sbjct: 1138 LKDEVSKCVCRCE 1150
Score = 60.9 bits (141), Expect = 2e-08
Identities = 87/489 (17%), Positives = 206/489 (42%), Gaps = 26/489 (5%)
Query: 109 QDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLR 168
Q + R++ +T + QIE ++EI+ L++ L+ + N+D +D K +
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK--RQL 880
Query: 169 INNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME-LSSLEEV 227
TN H + ++++ + + + +++ + + E + L
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 228 ITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL-EALKT 286
+ + DL+E+L ++ + + Q + ++ + E +R+ ++ L E+ +
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF 1000
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK 346
+ EK+ + + + +++ L+ +IES++ Q L +L L + E++
Sbjct: 1001 QTQLEKK--LMEVEKEKQELQDDKRRAIESMEQQ--------LSELKKTLSSVQNEVQEA 1050
Query: 347 LEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD 406
L++ + S + + +E+++ E ++ E+ + +++ L+ + + S
Sbjct: 1051 LQRASTALSNEQQ-ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASV 1109
Query: 407 LKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNK 466
+ + + +L K ++ E + LKDE + K + + K N + I EK
Sbjct: 1110 RQHLEETTQKAESQLLECKASWEERERMLKDE-VSKCVCRCEDLEKQNRLLHDQI-EKLS 1167
Query: 467 FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLEN-------ELTTYKNT 519
+ SV + L + L E EQ+ + ++ + KE+ E E Y+
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 520 LNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNE 579
+ RE E +++L N + K +T + E + E++ NV E + L K
Sbjct: 1228 VELLERELQELQDSL-NAEREKVQVTAKTMAQHEELMKKTETM-NVVMETNKMLREEKER 1285
Query: 580 LIEDVELLK 588
L +D++ ++
Sbjct: 1286 LEQDLQQMQ 1294
Score = 58.0 bits (134), Expect = 1e-07
Identities = 103/531 (19%), Positives = 224/531 (42%), Gaps = 61/531 (11%)
Query: 106 VQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLS 165
V+ + RN D + + +Q++ N +E+LK A K + + R LS
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN-AQK--------EIATLKRHLS 909
Query: 166 KLRINNTNCHTEHNAV-QGTDAEKVSAMINDMRS---RIIELEKKCEALDNEVYDKQMEL 221
+ + + ++ Q ++ E V +++ +R ++ +L+++ + + V Q +
Sbjct: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV 969
Query: 222 SSLEEVIT----VRDSLCKDLQEKL-------TSNELTLAETQQRLEMVKGHHALALEAN 270
+SLEE + V + + K+++ +L T E L E ++ + ++ A+E+
Sbjct: 970 TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESM 1029
Query: 271 ESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT-KHNASIE-SLKNQMLKE---- 324
E E K L +++ ++ E Q + +Q+ + + A I +N+ +E
Sbjct: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLH 1089
Query: 325 --KCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE-------H 375
EAL+ Q + K ++ LE+ + A +L C+ +EER + +++
Sbjct: 1090 AADVEALQAAKEQ-VSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCR 1148
Query: 376 CSQQEKTIQYLEQEIKEL--KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIK 433
C EK + L +I++L K + L L+ ++++ E FI K
Sbjct: 1149 CEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI-LEILRFIRREK 1207
Query: 434 TLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELE 493
+ + E + E + VE +E + + SL+ R+ V V + + + ++
Sbjct: 1208 EIAETRFEVA---QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 494 QLE------DQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKE 547
+ E + +ML KE LE +L + + + +EA L K+ + +
Sbjct: 1265 KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAE-LSEKSGMLQA 1323
Query: 548 HTRIMEHNVT--------LIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+++E +V L+ ++ + E YR+L + K + ++ L +E
Sbjct: 1324 EKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
>U63610-1|AAB05428.1| 4574|Homo sapiens plectin protein.
Length = 4574
Score = 67.7 bits (158), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1794
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1913
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1974 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2028
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2029 RQRKAALEEVERLKANVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2084
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2085 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Score = 61.3 bits (142), Expect = 1e-08
Identities = 118/552 (21%), Positives = 227/552 (41%), Gaps = 56/552 (10%)
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E E + E L D+ + LEE + D++E+L +L A + LE KG
Sbjct: 1885 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLA--QLRKASDSE-LERQKG 1938
Query: 262 HHALALEANESIRREYKIELEALKTKLDE------EKQAIISKCKVDQEN-LKTKHNASI 314
+E RR+ + E+ ALK ++ E + + + + + E+ L++K A +
Sbjct: 1939 ----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 315 ESLKNQML-----KEKCEALEQLHSQLIIKEQ---EMKAKLEQIEE---SASEKLKICEI 363
E+ + + L + + EA E++ L +E+ + KA LE++E + E ++ E
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKANVEEARRLRER 2054
Query: 364 QFEERSQSIQEHCSQQEKTIQY--------LEQEIKELKYTLDLTNNQNSDLKQELNNLK 415
+E ++ +Q +K +Q ++Q+ +EL+ TL + L+ E +
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIE-KTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+E + E + ++ E + + E+ A +A EK + E
Sbjct: 2115 RAAEEAEEARVQAEREAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 475 RDI-VHVLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
R LR +++ D+E+E+ + + K +E ELTT + L T D K
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKN 2230
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKES 591
L L+ L E T + E L +V + EL +K + E+ L+ ++
Sbjct: 2231 LLDEELQ---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDK 2286
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXX 651
++ +FL+EE EK + + E ++ A + E +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2346
Query: 652 XXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGK 710
L E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ +
Sbjct: 2347 QEATRLKAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 711 ENMQTISPLRER 722
+ +S ER
Sbjct: 2400 QRQLEMSAEAER 2411
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 266/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1975
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ ++ ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2036 EEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2096 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQARRQVEEAER--LKQSAEEQA 2152
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2264
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2265 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2317 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2366
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2367 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2420
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2421 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2506
Score = 59.7 bits (138), Expect = 4e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1331 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1445
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1446 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAETEAAR 1556
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERR 1640
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2297
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2358 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2536
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2597 QEELQQLEQQ 2606
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2218
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2450
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2455
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2515
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2516 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2566
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2627 LLEEQHRAALAHSEEVTASQVAATKTL 2653
>U53204-1|AAB05427.1| 4574|Homo sapiens plectin protein.
Length = 4574
Score = 67.7 bits (158), Expect = 1e-10
Identities = 96/461 (20%), Positives = 187/461 (40%), Gaps = 28/461 (6%)
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+E L AE +++ E + +A E R+ ++ + L+ + + +
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 299 CKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKL 358
+QE ++ + + Q+L+E+ L++ + K QE++A+L ++ + E L
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVL 1794
Query: 359 KICEIQFEERSQSIQEHCSQQEKT----IQYLEQEIKELKYTLDLTNNQNSDLKQELNNL 414
+ + EE S+S E Q+ + + L +E L+ + Q +++
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 415 KNCKDELSTEKFNFIEEIKTLKD--ELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLS 472
+ + + EK I E LK E+ K ENE+ + LA ++A + + E +
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1913
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
DI L + SDSELE+ + V+ + +E E+ K + E +
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESN 592
L I +S A T E L E+ RE E ++ ++E+
Sbjct: 1974 ELGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE----AEERVQKSLAAEEEAA 2028
Query: 593 SQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXX 652
Q K EEVE+ + E ++ LAQ AA RL+ E + +
Sbjct: 2029 RQRKAALEEVERLKANVE-EARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFA-- 2084
Query: 653 XXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
++Q+ +EL T+ ++ S++D+L+ + E ++
Sbjct: 2085 -----------VQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Score = 61.3 bits (142), Expect = 1e-08
Identities = 118/552 (21%), Positives = 227/552 (41%), Gaps = 56/552 (10%)
Query: 202 ELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKG 261
E E + E L D+ + LEE + D++E+L +L A + LE KG
Sbjct: 1885 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLA--QLRKASDSE-LERQKG 1938
Query: 262 HHALALEANESIRREYKIELEALKTKLDE------EKQAIISKCKVDQEN-LKTKHNASI 314
+E RR+ + E+ ALK ++ E + + + + + E+ L++K A +
Sbjct: 1939 ----LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 315 ESLKNQML-----KEKCEALEQLHSQLIIKEQ---EMKAKLEQIEE---SASEKLKICEI 363
E+ + + L + + EA E++ L +E+ + KA LE++E + E ++ E
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKANVEEARRLRER 2054
Query: 364 QFEERSQSIQEHCSQQEKTIQY--------LEQEIKELKYTLDLTNNQNSDLKQELNNLK 415
+E ++ +Q +K +Q ++Q+ +EL+ TL + L+ E +
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIE-KTINYENEKNKLNLAVEKAIKEKNKFETSLSVT 474
+E + E + ++ E + + E+ A +A EK + E
Sbjct: 2115 RAAEEAEEARVQAEREAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 475 RDI-VHVLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
R LR +++ D+E+E+ + + K +E ELTT + L T D K
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKN 2230
Query: 533 ALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNEL-IEDVELLKKES 591
L L+ L E T + E L +V + EL +K + E+ L+ ++
Sbjct: 2231 LLDEELQ---RLKAEATEAARQRSQVEEELFSVRVQ-MEELSKLKARIEAENRALILRDK 2286
Query: 592 NSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXX 651
++ +FL+EE EK + + E ++ A + E +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2346
Query: 652 XXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQ-SQYTPKSPSVLRKSLKVGK 710
L E LL+Q+ +EL A+ +L++D EQ +Q + +++L+ +
Sbjct: 2347 QEATRLKAEAELLQQQ-KELAQEQAR------RLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 711 ENMQTISPLRER 722
+ +S ER
Sbjct: 2400 QRQLEMSAEAER 2411
Score = 60.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 266/634 (41%), Gaps = 68/634 (10%)
Query: 106 VQAQDVEIRNKDQTICEYNKQ-IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKL 164
++ + ++R + E K +ED + Q++E + L F ++ E++ +L
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA--ELELEL 1975
Query: 165 SKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSL 224
++R N + + A + + R R E+ ++L E + ++L
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 225 EEVITVRDSL-----CKDLQEKLTSNELTLAE--TQQRLEMVKGHHALALEANE-----S 272
EEV ++ ++ ++ E+ ++ +L LA+ Q+RL+ + HA A++ E +
Sbjct: 2036 EEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 273 IRREYKIELEALKTKLDEEKQAI--ISKCKVDQENLKTKHNASIESLKNQMLKEKCEALE 330
+++E + L+ L+ + + ++A + +V E + +E + LK+ E
Sbjct: 2096 LQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQARRQVEEAER--LKQSAEEQA 2152
Query: 331 QLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQY---LE 387
Q +Q ++++ + EQ ++ + Q + +++H E+T++ +E
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 388 QEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYE 447
QE+ L+ L+ T++Q + L +EL LK E + ++ EE+ +++ ++
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-------- 2264
Query: 448 NEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKE 507
E +KL +E E + RD + E++ + E+ ++ +A+E
Sbjct: 2265 EELSKLKARIEA--------ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 508 VLENELTTYKNTLNNTVRECDEYKEALV-NILKSKAALTKEHTRIMEHNVTLIESLQNVE 566
L E + AL +LK K +E TR ++ L++ + +
Sbjct: 2317 AAR---------LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELA 2366
Query: 567 KEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXS 626
+E R L K ++ + L +E+ + L E E++R L EM S
Sbjct: 2367 QEQARRLQEDKEQMAQQ---LAEETQGFQRTL--EAERQRQL-EMSAEAERLKLRVAEMS 2420
Query: 627 RVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL--TMTVAKQSSIID- 683
R AQA R E + +R+ + L QE L T+ + +Q S D
Sbjct: 2421 R---AQA-----RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 684 -KLKKDLEQSQYTPKSPSVLRKSLKVGKENMQTI 716
+L++ + + + + K L++ E MQT+
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2506
Score = 59.7 bits (138), Expect = 4e-08
Identities = 77/384 (20%), Positives = 168/384 (43%), Gaps = 30/384 (7%)
Query: 238 LQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRR------EYKIELEALKTKLDEE 291
++E+L + L E ++ E V+ A + +I+ YK +LE + + +
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 292 KQAIISKCKVDQ-ENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ---EMKAKL 347
K S+ + + +L+T H + + +L +Q +K E L ++ + + EQ E + +L
Sbjct: 1331 KVQSGSESVIQEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
++E + ++ ++ E + ++Q+ +E Q++ +++E+ + Q +
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSI 1445
Query: 408 KQELNNLKNCKD-ELSTEKFNFIEEIKTLKDELIEKT-INYENEKNKLNLAVEKAIKEKN 465
++EL L+ + E+ + K + E E++ + E E + L +E +++
Sbjct: 1446 QEELQQLRQSSEAEI---------QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
E L R + R++ E E+L QVQ + K E EL + R
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAETEAAR 1556
Query: 526 ECDEYKEALVNI-LKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDV 584
E +AL + L+++ A + +E + +L+ ++ A EL + + E
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 585 ELLKK---ESNSQIKFLREEVEKK 605
L++ E + + LREE E++
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERR 1640
Score = 58.4 bits (135), Expect = 8e-08
Identities = 87/430 (20%), Positives = 183/430 (42%), Gaps = 39/430 (9%)
Query: 107 QAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELAT-KFRQSHNNIDFNEIDRKLS 165
QA+ +R K E K + + + Q ++ +EL T + + + N +D +L
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Query: 166 KLRINNTNCHTEHNAV---------QGTDAEKVSAMIN-DMRSRIIELEKKCEALDNEVY 215
+L+ T + + V Q + K+ A I + R+ I+ + + E
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2297
Query: 216 DKQMELSSLEEVITV---RDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANES 272
+K +++ ++V + + L E+ + + LAE + +M A L+A
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 273 IRREYKIELEALKTKLDEEKQAIISKCKVD----QENLKTKHNASIE-SLKNQMLK---- 323
+ ++ K + +L E+K+ + + + Q L+ + +E S + + LK
Sbjct: 2358 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 324 --EKCEALEQLHSQLIIKE-QEMKAKLEQIEESASEKLKICEIQFEERSQS------IQE 374
+ +A + +Q K+ +E+ KL + E + EK+ + + +R QS ++E
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 375 HCSQQEKTIQYLEQEIKELKY-TLDLTNNQNSDLKQELNNLKNC----KDELSTEKFNFI 429
++ E+ + L+QE K L+ + ++ Q L QE L+ KD L ++ FI
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFI 2536
Query: 430 EEIKTLKDELIEKTINYENE-KNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRES 488
E+ K ++L + + + + + ++ +E+ + S+ R H +R
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 489 DSELEQLEDQ 498
EL+QLE Q
Sbjct: 2597 QEELQQLEQQ 2606
Score = 54.0 bits (124), Expect = 2e-06
Identities = 86/453 (18%), Positives = 189/453 (41%), Gaps = 41/453 (9%)
Query: 186 AEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSN 245
AEK+ +R + E+ + D +ME T+R ++++LT+
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAA-LRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTL 2218
Query: 246 ELTLAETQQRLEMVKGH-HALALEANESIRREYKIE------------LEALKTKLDEEK 292
L L ET + ++ L EA E+ R+ ++E L LK +++ E
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 293 QAIISKCKVD-----QENLKTKHNASIESLKNQMLKEKCEALEQLHS-----QLIIKEQE 342
+A+I + K + QE + + E+ + + ++ L QL Q + E+
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 343 MKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKT--IQYLEQEIKELKYTLDLT 400
+K K++ ++E+ K + +Q ++ Q Q++K Q L +E + + TL+
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA 460
+ ++ E LK E+S + E+ + + + E KL+ E A
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA-------EEIGEKLH-RTELA 2450
Query: 461 IKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTT--YKN 518
+EK +L + R RLRE+ +ELE+ ++++Q ++ E+ T +
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 519 TLNNTVRECDEYKEALVNILKSKAALTKEHTR---IMEHNVTLIESLQNVEKEAYRELGT 575
L T + ++L+ + + +E + + + V + L+ ++ +++
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 576 IKNELIEDVELLKKESNSQIKFLREEVEKKRVL 608
+ L+ +E ++ + + +R + E+ + L
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Score = 50.8 bits (116), Expect = 2e-05
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 14/267 (5%)
Query: 197 RSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRL 256
R R +E+ + E L V + + EE +++ EKL EL TQ+++
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA---TQEKV 2455
Query: 257 EMVKGHHALALEANESIRR--EYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASI 314
+V+ +++ R E ELE K KL +E + + K + Q + +
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2515
Query: 315 ESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQE 374
++L+ L EK L++ + I EQE KAKLEQ+ + K + Q E Q Q+
Sbjct: 2516 QALQQSFLSEKDSLLQR--ERFI--EQE-KAKLEQLFQDEVAKAQ----QLREEQQRQQQ 2566
Query: 375 HCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKT 434
Q+ + + +E + ++ + + + Q+L + ++EL E+ + E
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 435 LKDELIEKTINYENEKNKLNLAVEKAI 461
L +E + + E +A K +
Sbjct: 2627 LLEEQHRAALAHSEEVTASQVAATKTL 2653
>M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac
myosin heavy chain mRNA, 3' end. ).
Length = 543
Score = 67.7 bits (158), Expect = 1e-10
Identities = 96/451 (21%), Positives = 191/451 (42%), Gaps = 44/451 (9%)
Query: 78 FKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQL 137
FK+ A S++ T + Q+E+ + ++ + +TI E K + + E +L
Sbjct: 90 FKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKMEL 148
Query: 138 QEILKELATKFRQSHNNI-----DFN----EIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
Q L+E I +FN EI+RKL++ H V +
Sbjct: 149 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 208
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
+ A R+ + ++KK E NE+ +++LS + K LQ L ++
Sbjct: 209 LDAETRS-RNEALRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 264
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
L + + + +K + A+ N ++ E LE L+ +++ ++ S+ D+E ++T
Sbjct: 265 LDDAVRANDDLKENIAIVERRNNLLQAE----LEELRAVVEQTER---SRKLADRELIET 317
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEER 368
+ +N L + + ++ SQL + +E + EE A + + + EE
Sbjct: 318 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 377
Query: 369 SQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN-QNSDLKQELNNL----KNCKDELST 423
+ Q+ + E+ + +EQ IK+L++ LD K++L L + ++EL
Sbjct: 378 KKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 436
Query: 424 EKFNFIEEIKTL-KDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLT 482
E+ E +K + K E K + Y+ E+++ NL +D+V L
Sbjct: 437 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR----------------LQDLVDKLQ 480
Query: 483 LRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
L+++ + E+ E+Q S +++EL
Sbjct: 481 LKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 511
Score = 66.9 bits (156), Expect = 2e-10
Identities = 90/434 (20%), Positives = 186/434 (42%), Gaps = 26/434 (5%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
++ + + ++ LEK L NE+ D +++ D ++ + L +
Sbjct: 6 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 65
Query: 247 LTLAETQQRLEMV-KGHHALALEANESIRREYKIELEALKTKLDEEK--QAIISKCKVDQ 303
E+Q LE K +L+ E + ++ Y+ LE L+T E K Q IS +Q
Sbjct: 66 QKYEESQSELESSQKEARSLSTELFK-LKNAYEESLEHLETFKRENKNLQEEISDL-TEQ 123
Query: 304 ENLKTKHNASIESLKNQMLKEKCE---ALEQLHSQLIIKEQE-MKAKLEQIEESASEKLK 359
K +E ++ Q+ EK E ALE+ + L +E + ++A+LE + A + K
Sbjct: 124 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 183
Query: 360 ICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKD 419
+ E + EE Q+ + H + L+ E + L + DL + L + +
Sbjct: 184 LAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA-N 241
Query: 420 ELSTEKFNFIEEIKTL-KDELIEKTINYE-NEKNKLNLAVEKAIKEKNKFETSLSVTRDI 477
++ E ++ +++L KD I+ N+ K N+A+ + + N + L R +
Sbjct: 242 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE--RRNNLLQAELEELRAV 299
Query: 478 VHVLTLRLRESDSELEQLEDQVQMLTSA-------KEVLENELTTYKNTLNNTVRECDEY 530
V + +D EL + ++VQ+L S K+ ++ +L+ + + V+EC
Sbjct: 300 VEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 359
Query: 531 KEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKE 590
+E + A + +E + + + L+ ++K + + +++ L E ++ K
Sbjct: 360 EEKAKKAITDAAMMAEELKKEQDTSA----HLERMKKNMEQTIKDLQHRLDEAEQIALKG 415
Query: 591 SNSQIKFLREEVEK 604
Q++ L V +
Sbjct: 416 GKKQLQKLEARVRE 429
Score = 54.4 bits (125), Expect = 1e-06
Identities = 64/321 (19%), Positives = 146/321 (45%), Gaps = 24/321 (7%)
Query: 185 DAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTS 244
D ++ ++ E +K+ ++L + + D Q++L ++ + D L +++
Sbjct: 229 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL---DDAVRANDDLKENIAIVERR 285
Query: 245 NELTLAETQQ-RLEMVKGHHALALEANESIRREYKIEL-EALKTKLDEEKQAIISKCKVD 302
N L AE ++ R + + + L E I +++L + T L +K+ K D
Sbjct: 286 NNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKK----KMDAD 341
Query: 303 QENLKTKHNASIESLKNQMLKEKCEALEQ-LHSQLIIKEQEMKAKLEQIEESASEKLKIC 361
L+T+ +++ +N K K + + ++ + KEQ+ A LE+++++ + +K
Sbjct: 342 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 401
Query: 362 EIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDEL 421
+ + +E Q + +Q +Q LE ++EL+ L+ +N++ + + + EL
Sbjct: 402 QHRLDEAEQIALKGGKKQ---LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL 458
Query: 422 STEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVL 481
+ + + + L+D L++K + K+ +A + + + T+LS R + H
Sbjct: 459 TYQTEEDRKNLLRLQD-LVDKL------QLKVKAYKRQAEEAEEQANTNLSKFRKVQH-- 509
Query: 482 TLRLRESDSELEQLEDQVQML 502
L E++ + E QV L
Sbjct: 510 --ELDEAEERADIAESQVNKL 528
Score = 50.0 bits (114), Expect = 3e-05
Identities = 63/341 (18%), Positives = 148/341 (43%), Gaps = 18/341 (5%)
Query: 366 EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEK 425
EE +++ CS EKT L+ EI++L ++ +N + L ++ N D++ E
Sbjct: 9 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF----DKILAEW 64
Query: 426 FNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRL 485
EE ++ + ++ + E KL A E++++ F+ ++ + LT +L
Sbjct: 65 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 124
Query: 486 RESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNN----TVRECDEYKEALVNILKSK 541
S + +LE + L + K L++ L + +L + +R E+ + I +
Sbjct: 125 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 184
Query: 542 AALTKEHTRIMEHNVTLIESLQ---NVEKEAYRELGTIKNEL---IEDVELLKKESNSQI 595
A +E + +++ +++SLQ + E + E +K ++ + ++E+ +N
Sbjct: 185 AEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMA 244
Query: 596 KFLREEVEKKRVLCE--MXXXXXXXXXXXXXXSRVLLAQAAADLSRLENENERYXXXXXX 653
+++V+ + L + + + + +L + E E R
Sbjct: 245 AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 304
Query: 654 XXSLVVELSLLRQENEELTMTVAKQSSIIDKLKK-DLEQSQ 693
+ + L+ + +E + + ++ +S+I++ KK D + SQ
Sbjct: 305 RSRKLADRELI-ETSERVQLLHSQNTSLINQKKKMDADLSQ 344
>BC094764-1|AAH94764.1| 692|Homo sapiens TPR protein protein.
Length = 692
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
>BC057235-1|AAH57235.1| 613|Homo sapiens HMMR protein protein.
Length = 613
Score = 67.7 bits (158), Expect = 1e-10
Identities = 113/524 (21%), Positives = 213/524 (40%), Gaps = 38/524 (7%)
Query: 179 NAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDL 238
N + T + + S+I L ++ A D + D + EL +E + L
Sbjct: 55 NVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL 114
Query: 239 QEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISK 298
+ E L E + E++K + N+ R +EL L+ K + + + +++K
Sbjct: 115 SANNATLEKQLIELTRTNELLKSK--FSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 172
Query: 299 CKVDQENLKTKHNASIESLKNQMLK-EKCEA-LEQLHSQLIIKEQEMKAKLEQIEE--SA 354
QE ++ K + SL+ K + E L + + I ++ E + LE IEE A
Sbjct: 173 ----QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA 228
Query: 355 SE-----KLKICEIQ--FEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSD- 406
S+ KL I +++ +E++ I E+ I L +++++L L + D
Sbjct: 229 SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDH 288
Query: 407 LKQELNNLKNCKDELSTEKFNFI----EEIKTLKDEL-IEKTINYENEKN-----KLNLA 456
+ + + +N E+ K FI E K + EL I+ + E E + KL
Sbjct: 289 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF 348
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
E+ +KEKN FE L T D + L + +++ ++QLE++ + ++LE +L
Sbjct: 349 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 408
Query: 517 KNTLNNTVRECDE----YKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRE 572
+ L + + +E ++++S +T + + IE L+ +E + +E
Sbjct: 409 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK-LENSSLQE 467
Query: 573 LGTIKNELIEDVE---LLKKESNSQIKFLREEVEKKRVL--CEMXXXXXXXXXXXXXXSR 627
+ EDV+ L + SN + + +++ K L E+
Sbjct: 468 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN 527
Query: 628 VLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEEL 671
L Q +LE+E R L E++ R EEL
Sbjct: 528 QLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL 571
Score = 52.0 bits (119), Expect = 7e-06
Identities = 83/394 (21%), Positives = 174/394 (44%), Gaps = 43/394 (10%)
Query: 106 VQAQDVEIRNKDQTICEY-------NKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFN 158
++ + ++ +++ + + EY + Q+E YK +IAQL+E LKE + +++ N
Sbjct: 204 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 263
Query: 159 EIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQ 218
+ LSK ++ + N Q + EK +N R L + + L + +Q
Sbjct: 264 IV--ILSK-QVEDLNV-----KCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQ 314
Query: 219 MELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK 278
E L++ DSL + +E +S L Q+ EMVK + E +++ K
Sbjct: 315 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE--EMVKEKNLFEEELKQTLDELDK 372
Query: 279 I-----ELEALKTKLDEEKQAIISKCKVDQENLKTKH-----NASIESLKNQMLKEKCEA 328
+ + E L +L+EE ++ + K+ +E LK K +++ + +L+EK ++
Sbjct: 373 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS 432
Query: 329 LEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQ 388
+ Q + + + KA + S E LK+ +E++ ++ + I E
Sbjct: 433 MVQSLEDVTAQFESYKA----LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATES 488
Query: 389 EIKE-LKYTLDLTNN---QNSDLKQ----ELNNLKNCKDELSTEKFNFIEEIKTLKDELI 440
+E ++ LDL + +++K+ L + + +++L ++ +F ++++ +
Sbjct: 489 SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKA 548
Query: 441 EK---TINYENEKNKLNLAVEKAIKEKNKFETSL 471
EK T E NK L E+ + F+ L
Sbjct: 549 EKENTTAELTEEINKWRLLYEELYNKTKPFQLQL 582
>BC028423-1|AAH28423.1| 1022|Homo sapiens PMFBP1 protein protein.
Length = 1022
Score = 67.7 bits (158), Expect = 1e-10
Identities = 113/506 (22%), Positives = 225/506 (44%), Gaps = 57/506 (11%)
Query: 127 IEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDA 186
+E+Y+N + L+ L+ ++ + R ++ E+D L LR T+ H E + D
Sbjct: 322 VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELD--LHGLR-EETSAHIER---KDKDI 375
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVIT-VRDSLCKDLQE----- 240
+ + +++ E +K D + +K L LE+ +T V++SL K +E
Sbjct: 376 TILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQ 435
Query: 241 -KLTSNELTLAETQQRLEMVKGHHALALEAN------ESIRREYKI--ELEALKTKLDEE 291
T E+T+ E +Q AL E E +++ ++ E A + +
Sbjct: 436 CMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAGEAPAAQQAAQCK 495
Query: 292 KQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
++A ++ C ++ K + ++ K ++E L+ L + + E+E + +++E
Sbjct: 496 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 555
Query: 352 ESA---SEKLKICEIQFEERSQSIQEHCSQQEKTI---------QYLEQ-EIK-----EL 393
E + SE L+ E +E+ Q +Q+ ++Q+ + Q+ EQ IK +L
Sbjct: 556 ELSLELSEALRKLENSDKEKRQ-LQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDL 614
Query: 394 KYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKL 453
+ L ++ LK+ + K + EL + F ++ KTLK+ + EN + +L
Sbjct: 615 QEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAEL 674
Query: 454 NLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENEL 513
+ NK+ TS V +D+ + L+ +ES L+ D+ L K L+ +
Sbjct: 675 QCCSTQLESSLNKYNTSQQVIQDLNKEIALQ-KESLMSLQAQLDKA--LQKEKHYLQTTI 731
Query: 514 TTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYREL 573
T K + R+ ++ L L+ +T E T+ ++ ++T Q EK+A
Sbjct: 732 T--KEAYDALSRKSAACQDDLTQALEKLNHVTSE-TKSLQQSLT-----QTQEKKA---- 779
Query: 574 GTIKNELIEDVELLKKESNSQIKFLR 599
++ E+I E +KK N++++ LR
Sbjct: 780 -QLEEEIIAYEERMKK-LNTELRKLR 803
Score = 62.5 bits (145), Expect = 5e-09
Identities = 105/512 (20%), Positives = 222/512 (43%), Gaps = 43/512 (8%)
Query: 100 LPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNE 159
L Q++L A D +I + ++++ Y + + + I L+ +K L + N+
Sbjct: 159 LAQEQLALAGD-KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENK 217
Query: 160 IDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQM 219
D SK+RI + C + + +V ++ I EL K + V +++
Sbjct: 218 GDH--SKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK 275
Query: 220 ELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKI 279
L L+ + + E + + + L+ K L +E +++ ++ ++
Sbjct: 276 ALIKLQADFASCTATHRYPPSSSEECE-DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRV 334
Query: 280 ELEALKTKLDEEKQAIIS---KCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQL 336
ELEA+ E+K+ I+ K ++D L+ + +A IE + +C L++L +
Sbjct: 335 ELEAVS----EQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCR-LQELQLEF 389
Query: 337 IIKEQEMKAKLEQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYT 396
+ Q++ K ++ + E L+ + E++ +Q ++EK ++ + EL+ T
Sbjct: 390 T-ETQKLTLKKDKFLQEKDEMLQ----ELEKKLTQVQNSLLKKEKELEKQQCMATELEMT 444
Query: 397 LDLTNNQNSDLKQELNNLKNCKD-ELSTEKF-NFIEEIKTLKDELIEKTINYENEKNKLN 454
+ + KQ+ + CK + +K N +EE K + E + + K
Sbjct: 445 V-------KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAGEAPAAQQAAQCKEE 497
Query: 455 LAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELT 514
A+ E + R + L L +++D+ +++L+ ++QML + E E T
Sbjct: 498 AALAGCHLEDTQ--------RKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQT 548
Query: 515 TYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELG 574
+ + + E E L N K K L K + E ++ + + L + K +RE G
Sbjct: 549 SNRKRVEELSLELSEALRKLENSDKEKRQLQKT---VAEQDMKMNDMLDRI-KHQHREQG 604
Query: 575 TIKNELIEDVELLKKESNSQIKFLREEVEKKR 606
+IK +L ED++ E+ ++ RE+++K +
Sbjct: 605 SIKCKLEEDLQ----EATKLLEDKREQLKKSK 632
Score = 50.0 bits (114), Expect = 3e-05
Identities = 106/476 (22%), Positives = 207/476 (43%), Gaps = 52/476 (10%)
Query: 211 DNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEAN 270
D EV +L SL+ I +CK ++ L N+L + E K ALA E +
Sbjct: 9 DREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEES 68
Query: 271 E----SIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKC 326
E S ++ + +L+ LK KL +Q + + E L+T + S+ ++ +L+++
Sbjct: 69 EVEFGSSKQCHLRQLQQLKKKLLVLQQEL----EFHTEELQTSY-YSLRQYQS-ILEKQT 122
Query: 327 EALEQLHSQLIIKEQEMKAKLEQI---EESASEKLKICEIQFE---------ERSQSIQE 374
L LH +KE E+ E++ E+ EKL + + Q ERS ++
Sbjct: 123 SDLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYR 182
Query: 375 HCSQQE-KTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLK----NC--KDELSTEK-F 426
Q I+ LE ++K L+ L Q + K + + ++ C ++ T+K
Sbjct: 183 DKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 242
Query: 427 NFIEEIKTLKDELIEKTINYENEKNKLNLAVEKA-IKEKNKFETSLSVTR---------- 475
+ + + + +D+LI++ N N L L EKA IK + F + + R
Sbjct: 243 SEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECE 302
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR-ECDEY---K 531
DI +L + DS+ +E+ ++ + LE +N + + ++ E D + +
Sbjct: 303 DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLRE 362
Query: 532 EALVNILKSKAALTKEHTRIMEHNVTLIESLQ-NVEKEAYRELGTIKNELIEDVELLKKE 590
E +I + +T R+ E + E+ + ++K+ + + K+E+++++E KK
Sbjct: 363 ETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQ---EKDEMLQELE--KKL 417
Query: 591 SNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQA-AADLSRLENENE 645
+ Q L++E E ++ C S+ +A A++ +L+N E
Sbjct: 418 TQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLE 473
Score = 48.0 bits (109), Expect = 1e-04
Identities = 85/380 (22%), Positives = 163/380 (42%), Gaps = 41/380 (10%)
Query: 76 KAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIEDYKNEIA 135
+A K+ + +KK+ +++ L + EL +A E + KD+T+ E ++++E+ +NE
Sbjct: 616 EATKLLEDKREQLKKS---KEHEKLMEGEL-EALRQEFKKKDKTLKENSRKLEE-ENE-- 668
Query: 136 QLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNTNCHTEHNAVQGTDAEKVSAMIND 195
L+ L+ +T+ S N +N + + L N + ++ A+ A+ +
Sbjct: 669 NLRAELQCCSTQLESSLNK--YNTSQQVIQDL---NKEIALQKESLMSLQAQLDKALQKE 723
Query: 196 MRSRIIELEKKC-EALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQ 254
+ K+ +AL + Q +L+ E + S K LQ+ LT + A+ ++
Sbjct: 724 KHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE 783
Query: 255 RL----EMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKTKH 310
+ E +K + L +E ++E+ A KL+E ++ K Q +LK
Sbjct: 784 EIIAYEERMKKLNT-ELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLK--- 839
Query: 311 NASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKICEIQFEERSQ 370
ML K E L + ++EM A E + E +K C Q+
Sbjct: 840 ----------MLAAKEEQLREF-------QEEMAALKENLLED--DKEPCCLPQWSVPKD 880
Query: 371 SIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFNFIE 430
+ + + ++ + LEQ K+ K + NQ + + + L KD L + + +
Sbjct: 881 TCRLYRGN-DQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQ 939
Query: 431 EIKTLKDELIEKTINYENEK 450
E K LK E+ EK + EN +
Sbjct: 940 ENKKLKKEIEEKKMKAENTR 959
>BC016514-1|AAH16514.1| 687|Homo sapiens TPR protein protein.
Length = 687
Score = 67.7 bits (158), Expect = 1e-10
Identities = 112/535 (20%), Positives = 225/535 (42%), Gaps = 52/535 (9%)
Query: 176 TEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEAL----DNEVYDKQMELSSLEEVITVR 231
TE N + + K+ + D +S I L+ + E + + ++ + LS +E +
Sbjct: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
Query: 232 DSLCKDLQ---EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKL 288
C+ L+ EKL + L E + LE+ + + +A+++ + +E ELEA K L
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN-IAIQSQFTRTKE---ELEAEKRDL 127
Query: 289 DEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLH-SQLIIKEQEMKAKL 347
+ + + + E++K + ES N E L++L S + +K +E + L
Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKES--NTTKGELQLKLDELQASDVSVKYREKR--L 183
Query: 348 EQIEESASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDL 407
EQ +E + + + ++ + +EK EI ELK L+ + S L
Sbjct: 184 EQEKELLHSQNTWLNTELKTKTDELL--ALGREKG-----NEILELKCNLENKKEEVSRL 236
Query: 408 KQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN---KLNLAVEKAIKEK 464
++++N LK + L + + ++K K++ + NE N KL+ + A +
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
Query: 465 NKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
L+ + +H L L+E+ + ++D + + +K+ +E E+ +
Sbjct: 297 EAKSNELTRAVEELHKL---LKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLE 350
Query: 525 RECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIE-- 582
+E + + L + A L++E M + + + +L + N +E
Sbjct: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV----KPGMKLTELYNAYVETQ 406
Query: 583 DVELLKKESNSQI-KFLRE---EVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLS 638
D LL+K N +I K+L E EVE K + + V L QA ++
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 639 RLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
RL+ + ++ + S+L ++N + + V S I L +LE+++
Sbjct: 467 RLQEDTDKANK----------QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Score = 66.1 bits (154), Expect = 4e-10
Identities = 86/386 (22%), Positives = 173/386 (44%), Gaps = 22/386 (5%)
Query: 224 LEEVI--TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIEL 281
L++V+ T + L K +Q KL E LA+ Q ++ +KG H +E E + L
Sbjct: 5 LQQVLERTELNKLPKSVQNKL---EKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRL 61
Query: 282 EALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQ 341
+ +L E + S +++ E L + A E KN+ L+ + + SQ ++
Sbjct: 62 SHSQERLVNETRECQS-LRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKE 118
Query: 342 EMKAKLEQIEESASEKLKICEIQF-EERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLT 400
E++A+ + + +E+L E+++ E + + E + T L+ ++ EL+ +
Sbjct: 119 ELEAEKRDLIRT-NERLSQ-ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 401 NNQNSDLKQELNNLKNCKDELSTEKFNFIEEIKTLK----DELIEKTINYENEKNKLNLA 456
+ L+QE L + L+TE +E+ L +E++E N EN+K +
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE---- 232
Query: 457 VEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTY 516
V + ++ N +TS + V L +L+E+ + +E++ +A L N Y
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN---LY 289
Query: 517 KNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTI 576
K+ +++ + +E A+ + K + + I +H + + +S +EKE ++G +
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 577 KNELIEDVELLKKESNSQIKFLREEV 602
+ EL +LL EE+
Sbjct: 350 EKELENANDLLSATKRKGAILSEEEL 375
>AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein
protein.
Length = 1331
Score = 67.7 bits (158), Expect = 1e-10
Identities = 105/536 (19%), Positives = 224/536 (41%), Gaps = 34/536 (6%)
Query: 187 EKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNE 246
+++ + +D+ +R+ E E++C+ L E Q + LEE + +S + LQ + + E
Sbjct: 775 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 834
Query: 247 LTLAETQQRLE--MVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQE 304
L + ++ L+ +V H N +++ +L A + + + + + +
Sbjct: 835 AKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAGERDRAEAEAR 894
Query: 305 NLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASE---KLKIC 361
+TK + +L+ M ++K E LE+L+ Q + +++ + + + +S E +
Sbjct: 895 EKETKALSLARALEEAM-EQKAE-LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 952
Query: 362 EIQFEERSQSIQE---HCSQQEKTIQYLEQEIKELK--YTLDL--TNNQNSDLKQEL-NN 413
E Q EE ++E E LE ++ +K + DL + Q+ + K++L
Sbjct: 953 EQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1012
Query: 414 LKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSL-S 472
++ + EL E+ + K +L + E + N ++AIK+ K + +
Sbjct: 1013 VREMEAELEDERKQRSMAVAARK-KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1071
Query: 473 VTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKE 532
R++ R E ++ ++ E +++ + + L+ EL + +E DE +
Sbjct: 1072 CMRELDDTRASR-EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1130
Query: 533 ALVNILKSKAALTKEHTRIMEHNVT-LIESLQ----NVE------KEAYRELGTIKNELI 581
+ N K AL E R +E + L E L+ N E K+A ++ I +L
Sbjct: 1131 EIAN-SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1189
Query: 582 EDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSRLE 641
+ +K N++ + R+ E K L EM +AQ L
Sbjct: 1190 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1249
Query: 642 NENE----RYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQ 693
E + + +++++ R+ E+ K S+ + +LK+ LE+++
Sbjct: 1250 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1305
Score = 57.2 bits (132), Expect = 2e-07
Identities = 94/460 (20%), Positives = 183/460 (39%), Gaps = 29/460 (6%)
Query: 291 EKQAIISKCKVDQENLKTKHNASIESLKNQMLKEK--CEALEQLHSQLIIKEQEMKAKLE 348
EKQ + E L+++ A L+ Q+ E C E+L ++L K+QE++
Sbjct: 723 EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 782
Query: 349 QIEESASEKLKICE-IQFEERS-----QSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNN 402
+E E+ + C+ +Q E++ Q ++E ++E Q L+ E + L
Sbjct: 783 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 842
Query: 403 QNSDLKQELNNLKN--CKDELSTEKFN-FIEEIKTL-------KDELIEKTINYENEKNK 452
+ DL +L++ + C E +KF+ + E KT+ +D + E +
Sbjct: 843 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAGERDRAEAEAREKETKALS 902
Query: 453 LNLAVEKAIKEK------NK-FETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSA 505
L A+E+A+++K NK F T + + + E + LE QV+ + +
Sbjct: 903 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 962
Query: 506 KEVLENELTTYKNTLNNTVRECDEYKEALVNILKSKAALTKEHTRIMEHNVTLIESLQNV 565
E LE EL ++ K L+ + ++E + + V +E+
Sbjct: 963 LEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1022
Query: 566 EKEAYRELGTIKNELIEDVELLKKESNSQIKFLREEVEKKRVLCEMXXXXXXXXXXXXXX 625
E++ + +L D++ L+ +S K E +++ R L
Sbjct: 1023 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1082
Query: 626 SRVLLAQAAADLSRLENENERYXXXXXXXXSLVVELSLLRQENEELTMTVAKQSSIIDKL 685
+LAQA + +L++ + +QE +EL +A S K
Sbjct: 1083 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG---KG 1139
Query: 686 KKDLEQSQYTPKSPSVLRKSLKVGKENMQTISP-LRERNL 724
LE+ + + L + L+ + N + I+ L++ NL
Sbjct: 1140 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1179
Score = 57.2 bits (132), Expect = 2e-07
Identities = 66/321 (20%), Positives = 137/321 (42%), Gaps = 18/321 (5%)
Query: 124 NKQIEDYKNEIA-QLQEILKELATKFRQSHNNIDFN---EIDRKLSKLRINNTNCHTEHN 179
++Q E+ K ++ Q++E+ EL + +Q + E+D K + I++ N + +
Sbjct: 999 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1058
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQ 239
Q K+ A + D + + E + + + + +L S+E + LQ
Sbjct: 1059 IKQ---LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI-------QLQ 1108
Query: 240 EKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKC 299
E+L + E + QQ + + A + ++ E K LEA +L+EE +
Sbjct: 1109 EELAAAERAKRQAQQERDELADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNT 1167
Query: 300 KVDQENLKTKHNASIESLKNQMLKEKCEAL--EQLHSQLIIKEQEMKAKLEQIEESASEK 357
++ + LK K N I+ + + E+ A E QL + +E+K KL+++E + K
Sbjct: 1168 ELINDRLK-KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1226
Query: 358 LKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNC 417
K E + ++E + K Q ++++ + L Q D ++ K+
Sbjct: 1227 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1286
Query: 418 KDELSTEKFNFIEEIKTLKDE 438
D+ ST +++ ++E
Sbjct: 1287 ADKASTRLKQLKRQLEEAEEE 1307
>AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens
cDNA FLJ43937 fis, clone TESTI4013924. ).
Length = 623
Score = 67.7 bits (158), Expect = 1e-10
Identities = 103/492 (20%), Positives = 217/492 (44%), Gaps = 36/492 (7%)
Query: 113 IRNKDQTICEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNIDFNEIDRKLSKLRINNT 172
+ KD+ Q+E+ E+ ++ ++ + ++ N+ D E +RK + L+I+
Sbjct: 24 MERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISEL 83
Query: 173 NCHTEHNAVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYD--KQMEL--SSLEEVI 228
H E Q AE+ + + + E EK+ E L + + +Q +L LE +
Sbjct: 84 TRHAEDATKQ---AERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 140
Query: 229 TVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK--IELEALKT 286
+ +L K N L E + +K AL+ E++R+E + AL+
Sbjct: 141 EKQSETVDELTGK---NNQILKEKDE----LKTQLYAALQQIENLRKELNDVLTKRALQE 193
Query: 287 KLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAK 346
+ K+ + K Q +L+ + S++++ L+ + + ++ SQ+ +++ ++ +
Sbjct: 194 EELHSKEEKLRDIKSHQADLELEVKNSLDTI--HRLESELKKQSKIQSQMKVEKAHLEEE 251
Query: 347 LEQIEES-ASEKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNS 405
+ ++++S A +K K+ E+Q +SI++ + + L +E + K L ++ +
Sbjct: 252 IAELKKSQAQDKAKLLEMQ-----ESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTA 306
Query: 406 DLKQELNNLKNCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKN 465
K +L E+ E+K L L +++ ++E+N L ++ KEK+
Sbjct: 307 QAKSRDEETATIITQLKLERDVHQRELKDLTSSL--QSVKTKHEQNIQEL-MKHFKKEKS 363
Query: 466 KFETSLSVTRDIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVR 525
+ E + + + +LE+L+ Q LT +E+ +NE K L
Sbjct: 364 EAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLT--EELTQNENENKKLKLKYQCL 421
Query: 526 ECDEYKEALVNILKSKAALTKEHTRIMEH-NVTLIESLQNVEKEAYRELGTIKNELIEDV 584
+ D+ +E +I ++ +EH R ME + L + L +E E LG I E+
Sbjct: 422 K-DQLEEREKHI-----SIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAAC 475
Query: 585 ELLKKESNSQIK 596
+ K+S ++K
Sbjct: 476 KTFSKDSVEKLK 487
Score = 61.3 bits (142), Expect = 1e-08
Identities = 105/526 (19%), Positives = 221/526 (42%), Gaps = 48/526 (9%)
Query: 70 LKFATPKAFKITKAPNSSIKKTLTCPKNKILPQDELVQAQDVEIRNKDQTICEYNKQIED 129
LK ++ + K + +++ L + DEL + ++ KD+ + ++
Sbjct: 118 LKLKAQESIRQWKLKHKKLERALEKQSETV---DELTGKNNQILKEKDELKTQLYAALQQ 174
Query: 130 YKNEIAQLQEILKELATKFRQSHNNID-FNEIDRKLSKLRINNTNCHTEHNAVQGTDAEK 188
+N +L ++L + A + + H+ + +I + L + N + ++ ++ +K
Sbjct: 175 IENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLE-SELKK 233
Query: 189 VSAMINDMRSRIIELEKKCEALDNEVYDKQMELSSLEEVITVRDSLCKDLQEKLTSNELT 248
S + + M+ LE++ L + +L ++E I ++ DL KL E
Sbjct: 234 QSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERA 293
Query: 249 LAETQQRLEMVKGHHALALEANESIRREYKIELEALKTKLDEEKQAIISKCKVDQENLKT 308
+ L + E +I + K+E + + +L + ++ +++KT
Sbjct: 294 KKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSL--------QSVKT 345
Query: 309 KHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIEESASEKLKI-CEIQFEE 367
KH +I+ L KEK EA + H + + E + + +I EKLK C+ EE
Sbjct: 346 KHEQNIQELMKHFKKEKSEA--ENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE 403
Query: 368 RSQSIQEHCSQQEKTIQYLEQEIKELKYTLDLTNNQNSDLKQELNNLKNCKDELSTEKFN 427
+Q+ E+ + K Q L+ +++E + + + +++ LK+ L TE+ +
Sbjct: 404 LTQNENENKKLKLK-YQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQES 462
Query: 428 FI----EEI----KTLKDELIEK--------TINYE------NEKNKLNLAVEKAIKEKN 465
+ +EI KT + +EK I+Y+ K KL E+ +KE+
Sbjct: 463 ILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEE-LKERE 521
Query: 466 KFETSLSVTRDIVHVLTLRLRES-DSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTV 524
E +L + L E+ +SEL+ L Q++ +E L +E+ K L
Sbjct: 522 NREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIE----RQEQLLDEIHREKRDLLEET 577
Query: 525 RECDEYKEAL---VNILKSKAALTKEHTRIMEHNVTLIESLQNVEK 567
+ DE +L V L++ + +H + ++L+E ++ +
Sbjct: 578 QRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRR 623
>AL137265-1|CAB70664.1| 992|Homo sapiens hypothetical protein
protein.
Length = 992
Score = 67.3 bits (157), Expect = 2e-10
Identities = 107/457 (23%), Positives = 209/457 (45%), Gaps = 33/457 (7%)
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME--LSSLEEVITVRDSLCKD 237
A++ + + D R + ++K + L ++ ++ E L ++ SL +
Sbjct: 365 ALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRER 424
Query: 238 LQEKLTSNELTLAETQ-QRLEMVKGHHALALEANES-IRREYKIELEALKTKLDEEKQA- 294
LQ+ + E + E + QRL ++ + +A+E IR E + L+ L+ +L+ +++A
Sbjct: 425 LQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAE 484
Query: 295 ---IISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
+ K + E LK + AS +S + + K +AL+QL QL + +E A LE+
Sbjct: 485 RASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEH 544
Query: 352 ESASEKL-KICEIQFEERSQSIQEHCSQ-QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
+ E+L E + E S+Q+ + Q+K L++ + ++++ + + + +
Sbjct: 545 SAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEH 604
Query: 410 ELNN-LKNCKDELSTEKFNFIEEIKTLKDELIEKT-INYENEKNK-----LNLAVEKAIK 462
EL++ L+ + E+ E ++++K +++ K YE E+ K L + +
Sbjct: 605 ELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELER 664
Query: 463 EKNKFETSLSVTRDIVHV----LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
+ E L R H L R RE + +L+ LE + + T AK+V + L +
Sbjct: 665 LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE--LDLETRAKDV-KARLALLEV 721
Query: 519 TLNNTVRECDEYKEALVNI-LKSKAALTKEHTRIME---HNVTLIESLQNVEKEAYRELG 574
RE + + + LKS+ A T H ++ E + L++S Q + +E EL
Sbjct: 722 QEETARREKQQLLDVQRQVALKSEEA-TATHQQLEEAQKEHTHLLQSNQQL-REILDELQ 779
Query: 575 TIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
K +L V+LL+ +S K L E +KK+ L
Sbjct: 780 ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHL 816
>AF273054-1|AAM44457.1| 613|Homo sapiens CTCL tumor antigen
HD-CL-01 protein.
Length = 613
Score = 67.3 bits (157), Expect = 2e-10
Identities = 93/483 (19%), Positives = 202/483 (41%), Gaps = 35/483 (7%)
Query: 258 MVKGHHALALEANESIRREYKIELEALKTKLDEEK---QAIISKCKVDQENLKTKHNASI 314
M KG HAL L + ++ +Y + +K + E K + + C +++NL+ +
Sbjct: 1 MNKGEHALVL-FEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICS-EKDNLREELKKRT 58
Query: 315 ESLKNQM--LKEKCEALEQLHSQ-------LIIKEQEMKAKLEQIEESASEKL----KIC 361
E+ K M +K+ +E+L+ + LI ++ K ++Q+ + ++++ K C
Sbjct: 59 ETEKQHMNTIKQLESRIEELNKEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQANKKC 118
Query: 362 EIQFEERSQSIQEHCSQQEKTI------QYLEQEIKELKYTLDLTNNQNSDLKQELNNLK 415
E +E+ + ++ +++++ + LE+++++ L+ N+ L QE L
Sbjct: 119 EEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH 178
Query: 416 NCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKNKLNLAVEKAIKEKNKFETSLSVTR 475
+ E I EI LK+++ I + +NKL ++ + K+K +
Sbjct: 179 QLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKL-------K 231
Query: 476 DIVHVLTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKNTLNNTVRECDEYKEALV 535
+ LT E+D + +D ++ ++E+ NEL + + + K +
Sbjct: 232 ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQL 291
Query: 536 NILKSKAALTKEHTRIMEHNVTLIESLQNVEKEAYRELGTIKNELIEDVELLKKESNSQI 595
+ +K ++ R + + + +L+ K E ++EL + E++ ++ ++I
Sbjct: 292 EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQ-KAEI 350
Query: 596 KFLREEVEKKRVLCEMXXXXXXXXXXXXXXSRVLLAQAAADLSR-LENENERYXXXXXXX 654
+ L ++V+ L E L DL + +E +R
Sbjct: 351 QNLLDKVKTADQLQEQLQRGKQEIENLKEEVE-SLNSLINDLQKDIEGSRKRESELLLFT 409
Query: 655 XSLVVELSLLRQENEELTMTVAKQSSIIDKLKKDLEQSQYTP-KSPSVLRKSLKVGKENM 713
L + + L+ E+ L K S +L+ EQ + T S L K ++ KE +
Sbjct: 410 ERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEV 469
Query: 714 QTI 716
QT+
Sbjct: 470 QTL 472
Score = 57.6 bits (133), Expect = 1e-07
Identities = 83/405 (20%), Positives = 177/405 (43%), Gaps = 29/405 (7%)
Query: 107 QAQDVEIRNKDQTI----CEYNKQIEDYKNEIAQLQEILKELATKFRQSHNNID--FNEI 160
+ + +++R + +T+ + NK++E N+I QL + L + EI
Sbjct: 136 EKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREI 195
Query: 161 DRKLSKLRINNTNCHTEHNAVQGT-DAEKVSA-MINDMRSRIIELEKKCEALDNEVYDKQ 218
D+ + + N ++ D+ K + + + +++ + +++ + + D
Sbjct: 196 DKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI 255
Query: 219 MELSSLEEVITVRDSLCKDLQEKLTSNELTLAETQQRLEMVKGHHALALEANESIRREYK 278
EE+ + + L D + ++T EL + Q++ + ++ HHA E E ++R +K
Sbjct: 256 KTYQESEEIKS--NEL--DAKLRVTKGELE-KQMQEKSDQLEMHHAKIKEL-EDLKRTFK 309
Query: 279 IELEALKTKLDEEKQAIISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLII 338
++ L+T + K + + + E K K + + + Q L +K + +QL QL
Sbjct: 310 EGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQR 369
Query: 339 KEQEMKAKLEQIEESAS---EKLKICEIQFEERSQSIQEHCSQQEKTIQYLEQEIKELKY 395
+QE++ E++E S + K E + S+ + K Q L+ E L+
Sbjct: 370 GKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQ-LQSESNSLQS 428
Query: 396 TLDLTNNQNSDLKQELNNLK----NCKDELSTEKFNFIEEIKTLKDELIEKTINYENEKN 451
D + S L+ + +K N + L E+ EE++TL+ EL + + E
Sbjct: 429 QFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACR----QTEVK 484
Query: 452 KLNLAVEKAIKEKNKFETSLSVTRDIVHVLTLRLRESDSELEQLE 496
L+ VE+ K++ T + LT +L+++ +L+Q+E
Sbjct: 485 ALSTQVEEL---KDELVTQRRKHASSIKDLTKQLQQARRKLDQVE 526
>AB028975-1|BAA83004.2| 1456|Homo sapiens KIAA1052 protein protein.
Length = 1456
Score = 67.3 bits (157), Expect = 2e-10
Identities = 107/457 (23%), Positives = 209/457 (45%), Gaps = 33/457 (7%)
Query: 180 AVQGTDAEKVSAMINDMRSRIIELEKKCEALDNEVYDKQME--LSSLEEVITVRDSLCKD 237
A++ + + D R + ++K + L ++ ++ E L ++ SL +
Sbjct: 595 ALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRER 654
Query: 238 LQEKLTSNELTLAETQ-QRLEMVKGHHALALEANES-IRREYKIELEALKTKLDEEKQA- 294
LQ+ + E + E + QRL ++ + +A+E IR E + L+ L+ +L+ +++A
Sbjct: 655 LQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAE 714
Query: 295 ---IISKCKVDQENLKTKHNASIESLKNQMLKEKCEALEQLHSQLIIKEQEMKAKLEQIE 351
+ K + E LK + AS +S + + K +AL+QL QL + +E A LE+
Sbjct: 715 RASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEH 774
Query: 352 ESASEKL-KICEIQFEERSQSIQEHCSQ-QEKTIQYLEQEIKELKYTLDLTNNQNSDLKQ 409
+ E+L E + E S+Q+ + Q+K L++ + ++++ + + + +
Sbjct: 775 SAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEH 834
Query: 410 ELNN-LKNCKDELSTEKFNFIEEIKTLKDELIEKT-INYENEKNK-----LNLAVEKAIK 462
EL++ L+ + E+ E ++++K +++ K YE E+ K L + +
Sbjct: 835 ELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELER 894
Query: 463 EKNKFETSLSVTRDIVHV----LTLRLRESDSELEQLEDQVQMLTSAKEVLENELTTYKN 518
+ E L R H L R RE + +L+ LE + + T AK+V + L +
Sbjct: 895 LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE--LDLETRAKDV-KARLALLEV 951
Query: 519 TLNNTVRECDEYKEALVNI-LKSKAALTKEHTRIME---HNVTLIESLQNVEKEAYRELG 574
RE + + + LKS+ A T H ++ E + L++S Q + +E EL
Sbjct: 952 QEETARREKQQLLDVQRQVALKSEEA-TATHQQLEEAQKEHTHLLQSNQQL-REILDELQ 1009
Query: 575 TIKNELIEDVELLKKESNSQIKF---LREEVEKKRVL 608
K +L V+LL+ +S K L E +KK+ L
Sbjct: 1010 ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHL 1046
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.308 0.125 0.320
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 79,731,527
Number of Sequences: 224733
Number of extensions: 3073947
Number of successful extensions: 37480
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 602
Number of HSP's successfully gapped in prelim test: 2596
Number of HSP's that attempted gapping in prelim test: 18441
Number of HSP's gapped (non-prelim): 11650
length of query: 724
length of database: 73,234,838
effective HSP length: 95
effective length of query: 629
effective length of database: 51,885,203
effective search space: 32635792687
effective search space used: 32635792687
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.7 bits)
S2: 69 (31.9 bits)
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