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Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA000896-TA|BGIBMGA000896-PA|IPR002524|Cation efflux
protein, IPR013032|EGF-like region, IPR003571|Snake toxin
         (322 letters)

Database: uniref50 
           1,657,284 sequences; 575,637,011 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q7K3K5 Cluster: LD22804p; n=7; Endopterygota|Rep: LD228...    97   5e-19
UniRef50_Q9VPE3 Cluster: CG5130-PA, isoform A; n=5; Diptera|Rep:...    94   5e-18
UniRef50_UPI00015B61F4 Cluster: PREDICTED: similar to GA14626-PA...    93   1e-17
UniRef50_UPI000155D410 Cluster: PREDICTED: similar to Eprs prote...    93   1e-17
UniRef50_A1DD01 Cluster: Metal ion resistance protein/transporte...    92   2e-17
UniRef50_Q0CAH3 Cluster: Predicted protein; n=1; Aspergillus ter...    92   2e-17
UniRef50_Q6XR72 Cluster: Solute carrier family 30 member 10; n=1...    90   6e-17
UniRef50_Q9Y6M5 Cluster: Zinc transporter 1; n=25; Euteleostomi|...    90   6e-17
UniRef50_A2R2G7 Cluster: Remark: the protein is probably respons...    89   2e-16
UniRef50_Q6P3M0 Cluster: Solute carrier family 30 (Zinc transpor...    87   4e-16
UniRef50_Q5GR56 Cluster: Zinc transporter 1; n=1; Glomus intrara...    87   4e-16
UniRef50_Q5KK51 Cluster: Di-, tri-valent inorganic cation transp...    86   1e-15
UniRef50_UPI0000DB7A0C Cluster: PREDICTED: similar to CG5130-PA,...    85   2e-15
UniRef50_A4R597 Cluster: Putative uncharacterized protein; n=1; ...    83   7e-15
UniRef50_P20107 Cluster: Zinc/cadmium resistance protein; n=7; S...    82   2e-14
UniRef50_A7TP59 Cluster: Putative uncharacterized protein; n=1; ...    81   3e-14
UniRef50_Q7S9J7 Cluster: Putative uncharacterized protein NCU077...    81   5e-14
UniRef50_Q2H0R9 Cluster: Putative uncharacterized protein; n=1; ...    80   7e-14
UniRef50_UPI0000D55EC2 Cluster: PREDICTED: similar to CG5130-PA,...    79   2e-13
UniRef50_Q54T06 Cluster: Cation efflux family protein; n=1; Dict...    78   4e-13
UniRef50_UPI000069F760 Cluster: solute carrier family 30 (zinc t...    77   6e-13
UniRef50_O13918 Cluster: Zinc homeostasis factor 1; n=1; Schizos...    77   8e-13
UniRef50_A2FW10 Cluster: Cation efflux family protein; n=4; Tric...    75   2e-12
UniRef50_A4QRA6 Cluster: Putative uncharacterized protein; n=2; ...    72   2e-11
UniRef50_Q75D95 Cluster: ABR129Cp; n=2; Saccharomycetaceae|Rep: ...    72   2e-11
UniRef50_A1DI13 Cluster: Zinc/cadmium resistance protein; n=8; P...    71   4e-11
UniRef50_UPI0000E49D68 Cluster: PREDICTED: similar to CG17723-PA...    71   5e-11
UniRef50_UPI000049966E Cluster: cation diffusion facilitator fam...    71   5e-11
UniRef50_Q2HFW8 Cluster: Putative uncharacterized protein; n=2; ...    70   9e-11
UniRef50_Q5BCD5 Cluster: Putative uncharacterized protein; n=1; ...    69   2e-10
UniRef50_A5ABY7 Cluster: Function: Zinc-replete cells accumulate...    68   3e-10
UniRef50_A1D9L0 Cluster: Di-, tri-valent inorganic cation transp...    68   4e-10
UniRef50_Q7QZ17 Cluster: GLP_464_49476_50732; n=1; Giardia lambl...    67   5e-10
UniRef50_Q7MUS7 Cluster: Heavy metal efflux pump, CzcD family; n...    66   1e-09
UniRef50_Q2PIQ1 Cluster: Zn2+ transporter ZNT1 and related Cd2+/...    66   2e-09
UniRef50_Q0C865 Cluster: Putative uncharacterized protein; n=1; ...    66   2e-09
UniRef50_O67168 Cluster: Cation efflux system; n=1; Aquifex aeol...    64   3e-09
UniRef50_A4X1A6 Cluster: Cation diffusion facilitator family tra...    64   3e-09
UniRef50_A3XRG5 Cluster: Cobalt/zinc/cadmium cation efflux pump ...    64   3e-09
UniRef50_A6SIM4 Cluster: Putative uncharacterized protein; n=2; ...    64   6e-09
UniRef50_A6SSD0 Cluster: Putative uncharacterized protein; n=2; ...    63   8e-09
UniRef50_Q6NHN1 Cluster: Cation-efflux system integral membrane ...    62   1e-08
UniRef50_A4XA76 Cluster: Cation diffusion facilitator family tra...    62   1e-08
UniRef50_Q7NRV3 Cluster: Probable cation efflux system; n=1; Chr...    62   2e-08
UniRef50_Q9PF12 Cluster: Cobalt-zinc-cadmium resistance protein;...    62   2e-08
UniRef50_Q4Q622 Cluster: Zinc transporter-like protein; n=3; Lei...    61   3e-08
UniRef50_Q6M5R5 Cluster: Co/Zn/Cd efflux system transmembrane pr...    60   6e-08
UniRef50_A7PMH0 Cluster: Chromosome chr14 scaffold_21, whole gen...    60   6e-08
UniRef50_Q98H85 Cluster: Cation efflux system protein; n=8; Alph...    60   1e-07
UniRef50_Q83EH0 Cluster: Cation-efflux family protein; n=3; Coxi...    59   2e-07
UniRef50_A0VV15 Cluster: Cation diffusion facilitator family tra...    59   2e-07
UniRef50_O45923 Cluster: Putative uncharacterized protein ttm-1;...    59   2e-07
UniRef50_Q1AYG3 Cluster: Cation diffusion facilitator family tra...    58   3e-07
UniRef50_A1UA75 Cluster: Cation diffusion facilitator family tra...    58   3e-07
UniRef50_Q57YU8 Cluster: Metal-ion transporter, putative; n=4; T...    58   3e-07
UniRef50_UPI0000F1F0D2 Cluster: PREDICTED: hypothetical protein;...    57   5e-07
UniRef50_Q4T2T2 Cluster: Chromosome undetermined SCAF10190, whol...    57   5e-07
UniRef50_Q1R0K1 Cluster: Cation diffusion facilitator family tra...    56   9e-07
UniRef50_Q1GPY2 Cluster: Cation diffusion facilitator family tra...    56   9e-07
UniRef50_A7I6Y5 Cluster: Cation diffusion facilitator family tra...    56   1e-06
UniRef50_A7B9C7 Cluster: Putative uncharacterized protein; n=1; ...    56   2e-06
UniRef50_A0NU32 Cluster: Cation efflux system protein; n=1; Stap...    56   2e-06
UniRef50_Q8IWU4 Cluster: Zinc transporter 8; n=18; Tetrapoda|Rep...    55   3e-06
UniRef50_UPI00006CBB53 Cluster: cation diffusion facilitator fam...    54   4e-06
UniRef50_Q9ABC7 Cluster: Cation efflux family protein; n=35; Bac...    54   4e-06
UniRef50_Q3SKU3 Cluster: Cation efflux protein; n=4; Proteobacte...    54   4e-06
UniRef50_Q4Y0W9 Cluster: Zinc transporter, putative; n=3; Plasmo...    54   4e-06
UniRef50_Q4SCU9 Cluster: Chromosome 14 SCAF14647, whole genome s...    54   5e-06
UniRef50_Q2J9T2 Cluster: Cation diffusion facilitator family tra...    53   9e-06
UniRef50_P13512 Cluster: Cobalt-zinc-cadmium resistance protein ...    53   9e-06
UniRef50_Q0EWA1 Cluster: Cation efflux transporter; n=1; Maripro...    53   1e-05
UniRef50_A5ESK1 Cluster: Cation efflux system protein czcD; n=4;...    53   1e-05
UniRef50_Q5NP70 Cluster: Cation efflux system protein; n=2; Zymo...    52   2e-05
UniRef50_Q0AGJ2 Cluster: Cation diffusion facilitator family tra...    52   2e-05
UniRef50_Q8IBU1 Cluster: Zinc transporter, putative; n=2; Plasmo...    52   2e-05
UniRef50_Q22GX2 Cluster: Cation diffusion facilitator family tra...    52   2e-05
UniRef50_A5JZM5 Cluster: Cation diffusion facilitator transporte...    52   2e-05
UniRef50_Q8KBG3 Cluster: Cation efflux family protein; n=5; Chlo...    52   2e-05
UniRef50_Q03ZB0 Cluster: Co/Zn/Cd efflux system component; n=1; ...    52   2e-05
UniRef50_A6Q136 Cluster: Cation efflux system protein, CDF famil...    52   2e-05
UniRef50_A0B5Z8 Cluster: Cation diffusion facilitator family tra...    52   2e-05
UniRef50_Q99726 Cluster: Zinc transporter 3; n=23; Mammalia|Rep:...    52   2e-05
UniRef50_Q64SU7 Cluster: Cation efflux system protein; n=5; Bact...    52   3e-05
UniRef50_A0RLZ7 Cluster: Cation efflux family protein; n=1; Camp...    52   3e-05
UniRef50_A5WCY6 Cluster: Cation diffusion facilitator family tra...    51   3e-05
UniRef50_A5DPS6 Cluster: Putative uncharacterized protein; n=1; ...    51   3e-05
UniRef50_UPI0000499CA1 Cluster: cation diffusion facilitator fam...    50   6e-05
UniRef50_Q4SHM2 Cluster: Chromosome 5 SCAF14581, whole genome sh...    50   6e-05
UniRef50_Q5FQH8 Cluster: Cation efflux system protein; n=1; Gluc...    50   6e-05
UniRef50_Q2LY02 Cluster: Cobalt-zinc-cadmium resistance protein;...    50   6e-05
UniRef50_Q4ECE6 Cluster: Cation efflux family protein; n=12; Ric...    50   1e-04
UniRef50_Q9V471 Cluster: CG3994-PA, isoform A; n=3; Sophophora|R...    50   1e-04
UniRef50_Q01NK8 Cluster: Cation diffusion facilitator family tra...    49   1e-04
UniRef50_A1IE74 Cluster: Cobalt-zinc-cadmium resistance protein;...    49   1e-04
UniRef50_A5VLM8 Cluster: Cation diffusion facilitator family tra...    49   2e-04
UniRef50_Q8TRQ7 Cluster: Cation efflux system protein; n=2; Meth...    49   2e-04
UniRef50_UPI0000DAE80F Cluster: hypothetical protein Rgryl_01001...    48   2e-04
UniRef50_Q7NDR3 Cluster: Gll4169 protein; n=3; Bacteria|Rep: Gll...    48   2e-04
UniRef50_Q5ALP0 Cluster: Potential vacuolar cation transporter; ...    48   2e-04
UniRef50_A3LTE1 Cluster: Zinc-and cadmium resistance protein; n=...    48   2e-04
UniRef50_Q0BUV7 Cluster: Cation efflux system protein; n=1; Gran...    48   3e-04
UniRef50_A3UGA9 Cluster: Cation efflux protein; n=3; Proteobacte...    48   3e-04
UniRef50_Q8EZ48 Cluster: Cobalt-zinc-cadmium resistance protein ...    48   4e-04
UniRef50_Q04D37 Cluster: Co/Zn/Cd efflux system component; n=2; ...    48   4e-04
UniRef50_A0FTM8 Cluster: Cation diffusion facilitator family tra...    48   4e-04
UniRef50_Q2UAQ9 Cluster: Zn2+ transporter ZNT1 and related Cd2+/...    48   4e-04
UniRef50_UPI0000D5546C Cluster: PREDICTED: similar to solute car...    47   6e-04
UniRef50_Q1II24 Cluster: Cation diffusion facilitator family tra...    47   6e-04
UniRef50_A0JRX0 Cluster: Cation diffusion facilitator family tra...    47   6e-04
UniRef50_Q8TCH2 Cluster: Zinc transporter-like 2 protein; n=37; ...    47   6e-04
UniRef50_Q9ZT63 Cluster: Metal tolerance protein 1 (AtMTP1) (Zin...    47   6e-04
UniRef50_Q1Q6G6 Cluster: Strongly similar to cation (Co/Zn/Cd) d...    47   7e-04
UniRef50_UPI00006CA446 Cluster: cation diffusion facilitator fam...    46   0.001
UniRef50_Q74FW5 Cluster: Cation efflux family protein; n=7; Desu...    46   0.001
UniRef50_A4SX31 Cluster: Cation diffusion facilitator family tra...    46   0.001
UniRef50_Q8ERA7 Cluster: Cation efflux system permease; n=14; Ba...    46   0.001
UniRef50_Q8U3B2 Cluster: Cation efflux system protein; n=5; cell...    46   0.001
UniRef50_Q9BRI3 Cluster: Zinc transporter 2; n=34; Eumetazoa|Rep...    46   0.001
UniRef50_Q95QW4 Cluster: Cation diffusion facilitator family pro...    46   0.002
UniRef50_Q4REH2 Cluster: Chromosome 10 SCAF15123, whole genome s...    45   0.002
UniRef50_A6SYW0 Cluster: Cobalt-zinc-cadmium resistance protein ...    45   0.002
UniRef50_Q7PWD5 Cluster: ENSANGP00000006521; n=1; Anopheles gamb...    45   0.002
UniRef50_A0DLG1 Cluster: Chromosome undetermined scaffold_55, wh...    45   0.002
UniRef50_Q5L2G4 Cluster: Cation efflux transporter; n=5; Bacilla...    45   0.003
UniRef50_Q2GIB0 Cluster: Cation efflux family protein; n=1; Anap...    45   0.003
UniRef50_A7NYR7 Cluster: Chromosome chr6 scaffold_3, whole genom...    45   0.003
UniRef50_Q5CSE6 Cluster: Cation diffusion facilitator like membr...    45   0.003
UniRef50_Q54QU8 Cluster: Putative uncharacterized protein; n=2; ...    45   0.003
UniRef50_Q83BX5 Cluster: Cation-efflux family protein; n=2; Coxi...    44   0.004
UniRef50_A7RHI7 Cluster: Predicted protein; n=1; Nematostella ve...    44   0.004
UniRef50_Q606W3 Cluster: Cation efflux family protein; n=2; Bact...    44   0.005
UniRef50_Q1H0B4 Cluster: Cation diffusion facilitator family tra...    44   0.005
UniRef50_A1RH26 Cluster: Cation diffusion facilitator family tra...    44   0.005
UniRef50_Q5XCQ6 Cluster: Cobalt-zinc-cadmium resistance protein;...    44   0.007
UniRef50_Q5FM42 Cluster: Cation efflux protein; n=5; Lactobacill...    44   0.007
UniRef50_A0ZGF9 Cluster: Cation efflux system protein; n=1; Nodu...    44   0.007
UniRef50_Q8SQT3 Cluster: ZINC TRANSPORTER; n=1; Encephalitozoon ...    44   0.007
UniRef50_Q8CNH2 Cluster: CzrB protein; n=3; Staphylococcus|Rep: ...    43   0.009
UniRef50_A5G751 Cluster: Cation diffusion facilitator family tra...    43   0.009
UniRef50_A1SIT8 Cluster: Cation diffusion facilitator family tra...    43   0.009
UniRef50_Q97G32 Cluster: Co/Zn/Cd efflux system component; n=1; ...    43   0.012
UniRef50_P72068 Cluster: Putative uncharacterized protein; n=1; ...    43   0.012
UniRef50_Q29M69 Cluster: GA16530-PA; n=2; Endopterygota|Rep: GA1...    43   0.012
UniRef50_Q9LXS1 Cluster: Metal tolerance protein A2; n=17; rosid...    43   0.012
UniRef50_UPI0000499414 Cluster: cation efflux protein; n=1; Enta...    42   0.016
UniRef50_Q8G4R7 Cluster: Probable cation efflux protein; n=4; Bi...    42   0.016
UniRef50_A1RH69 Cluster: Cation diffusion facilitator family tra...    42   0.016
UniRef50_A0AW44 Cluster: Cation diffusion facilitator family tra...    42   0.016
UniRef50_A3ETR2 Cluster: Co/Zn/Cd efflux system component; n=4; ...    42   0.021
UniRef50_A1ZDC5 Cluster: Heavy metal efflux pump, CzcD family; n...    42   0.021
UniRef50_Q9VKA3 Cluster: CG31860-PA; n=4; Diptera|Rep: CG31860-P...    42   0.021
UniRef50_Q22541 Cluster: Putative uncharacterized protein; n=3; ...    42   0.021
UniRef50_A3XEG4 Cluster: Cation efflux system protein; n=9; Prot...    42   0.028
UniRef50_A0S5V1 Cluster: Putative solute carrier family 30; n=1;...    42   0.028
UniRef50_UPI00015A66AB Cluster: solute carrier family 30 (zinc t...    41   0.037
UniRef50_Q3ZWB7 Cluster: Cation efflux family protein; n=2; Deha...    41   0.037
UniRef50_Q3VS68 Cluster: Cation efflux protein; n=2; Chlorobiace...    41   0.037
UniRef50_A5W938 Cluster: Cation diffusion facilitator family tra...    41   0.037
UniRef50_O14863 Cluster: Zinc transporter 4; n=33; Euteleostomi|...    41   0.037
UniRef50_Q83MV9 Cluster: Cation efflux protein; n=2; Tropheryma ...    41   0.049
UniRef50_Q4T2L9 Cluster: Chromosome undetermined SCAF10234, whol...    40   0.065
UniRef50_Q6ML10 Cluster: Cation-efflux system membrane protein; ...    40   0.065
UniRef50_A6LME7 Cluster: Cation diffusion facilitator family tra...    40   0.065
UniRef50_A0BG38 Cluster: Chromosome undetermined scaffold_105, w...    40   0.065
UniRef50_UPI00005852CD Cluster: PREDICTED: similar to solute car...    40   0.086
UniRef50_Q8T0G1 Cluster: LD05335p; n=1; Drosophila melanogaster|...    40   0.086
UniRef50_Q45EL5 Cluster: Similar to transporter of divalent cati...    40   0.086
UniRef50_Q1ZSN3 Cluster: Cation diffusion facilitator family tra...    40   0.11 
UniRef50_Q0ICB8 Cluster: Cation efflux system protein; n=2; Syne...    40   0.11 
UniRef50_Q02XW1 Cluster: Co/Zn/Cd efflux system component; n=3; ...    40   0.11 
UniRef50_Q5ZRY2 Cluster: Cation efflux system protein; n=4; Legi...    39   0.15 
UniRef50_Q9ALR5 Cluster: CztD; n=1; Pseudomonas fluorescens|Rep:...    39   0.15 
UniRef50_O85143 Cluster: Transport protein; n=35; Bacteria|Rep: ...    39   0.15 
UniRef50_A0LXC1 Cluster: CDF family cation efflux protein; n=3; ...    39   0.15 
UniRef50_Q8WQB6 Cluster: Putative uncharacterized protein; n=2; ...    39   0.20 
UniRef50_Q6DBM8 Cluster: Metal tolerance protein B; n=1; Arabido...    39   0.20 
UniRef50_UPI0000DAE7E5 Cluster: hypothetical protein Rgryl_01001...    38   0.26 
UniRef50_UPI0000DD7936 Cluster: PREDICTED: similar to solute car...    38   0.35 
UniRef50_Q6QSW0 Cluster: Cation efflux facilitator; n=1; Enteroc...    38   0.35 
UniRef50_A3VSL3 Cluster: Cation efflux protein; n=1; Parvularcul...    38   0.35 
UniRef50_Q5V738 Cluster: Cation efflux system protein; n=1; Halo...    38   0.35 
UniRef50_Q5LTM6 Cluster: Cation efflux system protein; n=13; Alp...    38   0.46 
UniRef50_A7HC19 Cluster: Cation diffusion facilitator family tra...    38   0.46 
UniRef50_A3PRE9 Cluster: Cation diffusion facilitator family tra...    38   0.46 
UniRef50_Q6A8D8 Cluster: Cation-efflux transport protein; n=2; A...    37   0.61 
UniRef50_A1W9S8 Cluster: Cation diffusion facilitator family tra...    37   0.61 
UniRef50_UPI0000D56740 Cluster: PREDICTED: similar to T18D3.3; n...    37   0.80 
UniRef50_Q01S49 Cluster: Putative uncharacterized protein; n=1; ...    37   0.80 
UniRef50_Q4DHZ0 Cluster: Zinc transporter, putative; n=2; Trypan...    36   1.1  
UniRef50_Q2U893 Cluster: Amino acid transporters; n=1; Aspergill...    36   1.1  
UniRef50_UPI0000E4799B Cluster: PREDICTED: similar to zinc trans...    36   1.4  
UniRef50_A1JTE6 Cluster: Putative oxidoreductase; n=1; Yersinia ...    36   1.4  
UniRef50_Q54F34 Cluster: Putative uncharacterized protein; n=1; ...    36   1.4  
UniRef50_Q6D7E5 Cluster: Zinc transporter zitB; n=40; Enterobact...    36   1.4  
UniRef50_Q97NZ2 Cluster: Cation efflux system protein; n=27; Str...    36   1.9  
UniRef50_Q11KC0 Cluster: Cation diffusion facilitator family tra...    36   1.9  
UniRef50_A6SZ19 Cluster: Cobalt-zinc-cadmium resistance protein ...    35   2.4  
UniRef50_A1B355 Cluster: Cation diffusion facilitator family tra...    35   2.4  
UniRef50_Q4PIG2 Cluster: Putative uncharacterized protein; n=1; ...    35   2.4  
UniRef50_Q4WSP3 Cluster: Cation efflux family protein family; n=...    35   3.2  
UniRef50_A5UXA7 Cluster: Putative uncharacterized protein precur...    34   5.7  
UniRef50_Q97WH2 Cluster: Probable cation transport protein; n=1;...    34   5.7  
UniRef50_Q3JD39 Cluster: Putative uncharacterized protein; n=1; ...    33   7.5  
UniRef50_A4BD66 Cluster: Na+-driven multidrug efflux pump; n=1; ...    33   7.5  
UniRef50_Q7PWF8 Cluster: ENSANGP00000019448; n=3; Culicidae|Rep:...    33   7.5  
UniRef50_A3RS25 Cluster: CzcD; n=3; Ralstonia solanacearum|Rep: ...    33   9.9  
UniRef50_A0NSQ9 Cluster: Carbon monoxide dehydrogenase operon C ...    33   9.9  
UniRef50_Q16990 Cluster: Mini-collagen; n=10; Cnidaria|Rep: Mini...    33   9.9  
UniRef50_Q6UX54 Cluster: Solute carrier family 30 member 5; n=49...    33   9.9  

>UniRef50_Q7K3K5 Cluster: LD22804p; n=7; Endopterygota|Rep: LD22804p
           - Drosophila melanogaster (Fruit fly)
          Length = 449

 Score = 97.1 bits (231), Expect = 5e-19
 Identities = 61/204 (29%), Positives = 103/204 (50%), Gaps = 9/204 (4%)

Query: 116 SSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSA 175
           SSHG      ++ +  A + +L +A+  +++  S  V+      EW++      DPALS 
Sbjct: 184 SSHGHSHDPGQMNMRGAFLHVLSDALGSIIVVISAVVV---WKTEWKYRY--YMDPALSI 238

Query: 176 CAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAAL-RVPGVFAIHELHVWQLHRDK 234
              ++++   +P +R + L+LLQTVP  +    ++   L +V GV A+HE HVWQL  D+
Sbjct: 239 VLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDR 298

Query: 235 VVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKELIAYGN 294
           ++A+AH+      +Y+K +  V + F   GI   T+QPEF         +    +   G+
Sbjct: 299 IIASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPEFSEIEGCNMSDGTSSINISGS 358

Query: 295 LGCS--CPCVKE-CTGPRCCEPPN 315
             C+  CP  +E C    CC+  N
Sbjct: 359 DCCALDCPTTEEGCVKATCCQNNN 382



 Score = 49.6 bits (113), Expect = 1e-04
 Identities = 33/113 (29%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           + TNS  L+ D+ H L  +  L+ + +S K              +NTFGWAR EV+G L 
Sbjct: 30  YVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWS-------KNTFGWARAEVLGALV 82

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL 146
             V   +   ++ + A +  +      P   P ++V    +GLL N I   LL
Sbjct: 83  NAVFLVALCFSITIEACKRFIEEE---PIHEPELLVIVGALGLLVNVIGLCLL 132


>UniRef50_Q9VPE3 Cluster: CG5130-PA, isoform A; n=5; Diptera|Rep:
           CG5130-PA, isoform A - Drosophila melanogaster (Fruit
           fly)
          Length = 513

 Score = 93.9 bits (223), Expect = 5e-18
 Identities = 58/174 (33%), Positives = 89/174 (51%), Gaps = 20/174 (11%)

Query: 146 LAGSLFVIAAGL---TEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPE 202
           ++ ++FVI         E E   ++  DP LS  + ++LV  +YP+M+ + L+LLQT+P 
Sbjct: 252 VSSTIFVIVCAAIVYVAEDEQHTAKFIDPVLSIFSCVLLVTLSYPYMKESCLILLQTIP- 310

Query: 203 GLGACDL----RTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCD 258
             G+ DL    RT   + P + + H+LH+WQL   + VAT H+ +   + YLK    V  
Sbjct: 311 --GSIDLEIFERTLVTKFPEIISYHDLHIWQLAAHRYVATIHIQFQNPKLYLKIIEQVRS 368

Query: 259 VFKRHGIGLVTLQPEFMLTSSRGTEEEKKELIAYGNLGCSCPC-VKECTGPRCC 311
            F   GIG VT+QPEF  ++++          A  +L C   C   EC    CC
Sbjct: 369 YFHDQGIGAVTIQPEFYPSTNKN---------ASASLECLMQCQAVECIEKVCC 413



 Score = 70.5 bits (165), Expect = 5e-11
 Identities = 33/76 (43%), Positives = 47/76 (61%)

Query: 73  REGRLRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSA 132
           RE +LRNTFGWARI+++  L V ++ AS + +LVV ALQ  VH  H      P  ++   
Sbjct: 103 REQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTLVHIDHQDTMHLPIPVMMLG 162

Query: 133 VIGLLFNAINYMLLAG 148
            IGL+ N + Y+L+ G
Sbjct: 163 FIGLILNGLTYLLIGG 178


>UniRef50_UPI00015B61F4 Cluster: PREDICTED: similar to GA14626-PA;
            n=2; Apocrita|Rep: PREDICTED: similar to GA14626-PA -
            Nasonia vitripennis
          Length = 2810

 Score = 92.7 bits (220), Expect = 1e-17
 Identities = 56/173 (32%), Positives = 86/173 (49%), Gaps = 9/173 (5%)

Query: 148  GSLFVIAAGLT---EEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGL 204
            GS+ VI + L      WE+      DPALS    ++++   +P ++ + L+LLQTVP  +
Sbjct: 2566 GSVIVIVSALIVWLTNWEYRF--YIDPALSLLLVMLILKSVWPLLQESALILLQTVPTHI 2623

Query: 205  GACDLRTAALR-VPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRH 263
                ++   L  + GV A+HE HVWQL  D+++A+AH+      +Y+K +  V + F   
Sbjct: 2624 QVDAIQQRLLENIDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSEYMKIAEQVKEFFHNE 2683

Query: 264  GIGLVTLQPEFMLTSSRGTEEEKKELIAYGNLGC--SCPCV-KECTGPRCCEP 313
            GI   T+QPEF+   S    +   E+       C   CP   K C    CC P
Sbjct: 2684 GIHSTTIQPEFIDVKSIYMYQSNSEIKETPTEDCVLDCPKTDKSCNQATCCGP 2736



 Score = 41.9 bits (94), Expect = 0.021
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 14/114 (12%)

Query: 34   HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
            + TNS  L+ D+ H L  +  L+   +S K              +NTFGWAR EV+G L 
Sbjct: 2387 YVTNSMALIADSFHMLSDVAALVVAFLSVKMSPKKWS-------KNTFGWARAEVLGALV 2439

Query: 94   VHVLFASFALALVVNALQ--LGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              V   +   ++ V A +  + V   H       +++V    +GL+ N +   L
Sbjct: 2440 NAVFLVALCFSITVEACKRFIEVEKIHD-----AKLLVVVGALGLVVNLVGLCL 2488


>UniRef50_UPI000155D410 Cluster: PREDICTED: similar to Eprs protein;
           n=1; Ornithorhynchus anatinus|Rep: PREDICTED: similar to
           Eprs protein - Ornithorhynchus anatinus
          Length = 668

 Score = 92.7 bits (220), Expect = 1e-17
 Identities = 53/180 (29%), Positives = 93/180 (51%), Gaps = 10/180 (5%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSA 192
           V+G    ++  ++ A   +V+    +E    E     DP+L+    I+++   +P ++  
Sbjct: 429 VMGDALGSVVVVIAATIFYVLPLDPSEPCNWEC--YIDPSLTILMVIIILSSAFPLIKET 486

Query: 193 GLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKN 252
             +LLQ VP+G+   +L     +VPG+ +IH++H+W+L   K +AT HV      DY   
Sbjct: 487 ATILLQMVPKGVNVEELTIQLSQVPGISSIHDVHIWELASGKTIATLHVKCQKSRDYRDA 546

Query: 253 SALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKELIAYGNLGCSCPCV-KECTGPRCC 311
           +  + ++F   GI  VT+QPE+ L     T  + K+L+ +    CS PC+ K C+   CC
Sbjct: 547 NFKMREIFHNAGIHSVTIQPEY-LDPKEPT--DPKDLVLF----CSSPCISKACSSKLCC 599


>UniRef50_A1DD01 Cluster: Metal ion resistance protein/transporter
           (Zrc1), putative; n=3; Pezizomycotina|Rep: Metal ion
           resistance protein/transporter (Zrc1), putative -
           Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
           181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
           3700 / NRRL 181))
          Length = 401

 Score = 92.3 bits (219), Expect = 2e-17
 Identities = 49/150 (32%), Positives = 90/150 (60%), Gaps = 6/150 (4%)

Query: 152 VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRT 211
           +IAA +  + ++E    ADPA+S   AIV+++ + P +R +G +LLQ+VP G+   D++ 
Sbjct: 212 IIAALVIWKAKYEGRYYADPAVSMAIAIVILLSSLPLVRKSGTILLQSVPLGVDPEDVKH 271

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTH--EDYLKNSALVCDVFKRHGIGLVT 269
               +PGV ++HELH+W+L+++K +A+ H+        D++  + ++ + F  +GI   T
Sbjct: 272 DLEAIPGVESVHELHIWRLNQEKALASVHLAVSDELIADFMDKAKIINECFHAYGIHSTT 331

Query: 270 LQPEFML---TSSRGTE-EEKKELIAYGNL 295
           LQPE +    + SR  + ++  ELI  G +
Sbjct: 332 LQPEHVRPIPSDSRSIQGQDTAELIVEGGV 361



 Score = 36.3 bits (80), Expect = 1.1
 Identities = 27/112 (24%), Positives = 48/112 (42%), Gaps = 8/112 (7%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           +T S  L+ D  H L  LVG I  L++ K  +  +          +FGW R +++G    
Sbjct: 31  YTRSLALVADAFHYLNDLVGFIVALVALKISQRSKHPKEL-----SFGWQRAQLLGAFFN 85

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL 146
            V   S  +++ + ++   V       P+   +I     +GL  N I+ + L
Sbjct: 86  GVFLLSLGISIFLQSIDRFVSLERIENPKLVLII---GCVGLALNLISGLFL 134


>UniRef50_Q0CAH3 Cluster: Predicted protein; n=1; Aspergillus
           terreus NIH2624|Rep: Predicted protein - Aspergillus
           terreus (strain NIH 2624)
          Length = 365

 Score = 91.9 bits (218), Expect = 2e-17
 Identities = 49/131 (37%), Positives = 83/131 (63%), Gaps = 5/131 (3%)

Query: 147 AGSLFVIAAGLTEEW--EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGL 204
           A +L VI AGL   W  ++     ADPA+S   AI+++  + P ++ +GL+LLQ+ P+G+
Sbjct: 186 ANNLGVIIAGLVI-WLADYGGRYYADPAVSMAIAIMILFSSLPLIKRSGLILLQSAPDGV 244

Query: 205 GACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED--YLKNSALVCDVFKR 262
              D++    ++PG+ A+HELH+W+L++ K +A+AH++    +D  + K +  V + F  
Sbjct: 245 EHEDVKHDLEQIPGIRAVHELHIWRLNQKKSLASAHLVLENDDDLEFHKLAKTVNECFHA 304

Query: 263 HGIGLVTLQPE 273
           +GI  VTLQPE
Sbjct: 305 YGIHSVTLQPE 315


>UniRef50_Q6XR72 Cluster: Solute carrier family 30 member 10; n=18;
           Amniota|Rep: Solute carrier family 30 member 10 - Homo
           sapiens (Human)
          Length = 496

 Score = 90.2 bits (214), Expect = 6e-17
 Identities = 47/149 (31%), Positives = 80/149 (53%), Gaps = 8/149 (5%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP+L+    I+++   +P ++    +LLQ VP+G+   +L +    VPG+ ++HE+H+W+
Sbjct: 280 DPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWE 339

Query: 230 LHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKEL 289
           L   K++AT H+ Y     Y   S  + ++F   GI  VT+Q E +         E+K+L
Sbjct: 340 LVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKE---PLEQKDL 396

Query: 290 IAYGNLGCSCPCV-KECTGPRCCEPPNIP 317
           +    L C+ PC+ K C    CC P  +P
Sbjct: 397 L----LLCNSPCISKGCAKQLCCPPGALP 421


>UniRef50_Q9Y6M5 Cluster: Zinc transporter 1; n=25;
           Euteleostomi|Rep: Zinc transporter 1 - Homo sapiens
           (Human)
          Length = 507

 Score = 90.2 bits (214), Expect = 6e-17
 Identities = 48/139 (34%), Positives = 70/139 (50%), Gaps = 8/139 (5%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP L      +L+   YP ++ + L+LLQTVP+ +   +L      V GV  +HELHVWQ
Sbjct: 317 DPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKELRNVEGVEEVHELHVWQ 376

Query: 230 LHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKEL 289
           L   +++AT H+       Y++ +  + DVF  HGI   T+QPEF    S       K  
Sbjct: 377 LAGSRIIATVHIKCEDPTSYMEVAKTIKDVFHNHGIHATTIQPEFASVGS-------KSS 429

Query: 290 IAYGNLGCSCPC-VKECTG 307
           +    L C   C +K+C G
Sbjct: 430 VVPCELACRTQCALKQCCG 448



 Score = 54.0 bits (124), Expect = 5e-06
 Identities = 32/113 (28%), Positives = 55/113 (48%), Gaps = 8/113 (7%)

Query: 33  SHFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRL 92
           S  T+S  +L D+ H L  ++ L+  L++ ++ R    T +     NTFGW R EV+G L
Sbjct: 29  SRVTSSLAMLSDSFHMLSDVLALVVALVAERFARRTHATQK-----NTFGWIRAEVMGAL 83

Query: 93  SVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +       A+++ A++  +        + P V++G  V GLL N +   L
Sbjct: 84  VNAIFLTGLCFAILLEAIERFIEPHE---MQQPLVVLGVGVAGLLVNVLGLCL 133


>UniRef50_A2R2G7 Cluster: Remark: the protein is probably
           responsible for the uptake of zinc and cadmium ions;
           n=2; Aspergillus|Rep: Remark: the protein is probably
           responsible for the uptake of zinc and cadmium ions -
           Aspergillus niger
          Length = 408

 Score = 88.6 bits (210), Expect = 2e-16
 Identities = 55/186 (29%), Positives = 96/186 (51%), Gaps = 9/186 (4%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRI-ADPALSACAAIVLVVFNYPFMRS 191
           ++G+L + I     A +L V+AA L     H   R  ADP  S   +I++++ + P +R 
Sbjct: 224 MLGVLIHVIGDA--ANNLGVMAAALVIWLAHYGGRYYADPGTSMGISIMIMLSSVPLVRR 281

Query: 192 AGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYG--THEDY 249
            G++LL++ P G+   D++    ++PGV ++HELH+W+L++ K +A+ HV+    +   +
Sbjct: 282 CGIILLESAPNGVDLEDVKHDLEKIPGVLSVHELHIWRLNQHKALASVHVMVSDCSVPSF 341

Query: 250 LKNSALVCDVFKRHGIGLVTLQPEFMLTS--SRGTEEEKKELIAYGNLG--CSCPCVKEC 305
           LK S  + + F  +GI   T+QPE       + G    + EL +   +   C   C   C
Sbjct: 342 LKLSKTINECFHAYGIHSTTIQPEMAHPEAIALGRPAVETELSSQTEMSEKCQVICGTLC 401

Query: 306 TGPRCC 311
               CC
Sbjct: 402 EELTCC 407


>UniRef50_Q6P3M0 Cluster: Solute carrier family 30 (Zinc
           transporter), member 1; n=5; Euteleostomi|Rep: Solute
           carrier family 30 (Zinc transporter), member 1 - Danio
           rerio (Zebrafish) (Brachydanio rerio)
          Length = 498

 Score = 87.4 bits (207), Expect = 4e-16
 Identities = 46/142 (32%), Positives = 69/142 (48%), Gaps = 11/142 (7%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP L      +L+   YP ++ + L+LLQTVP+ +    L      + GV A+HELH+WQ
Sbjct: 307 DPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDMHQLNARLRDLEGVLAVHELHIWQ 366

Query: 230 LHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKEL 289
           L   +++ATAH+       Y+  +  + D F   GI   T+QPEF+  +S    E +  L
Sbjct: 367 LAGSRIIATAHIKCHDPTSYMDVAKRIKDFFHDEGIHATTIQPEFVTVNS----ESRASL 422

Query: 290 IAYGNLGCSCPCVKECTGPRCC 311
                  C   C  +C    CC
Sbjct: 423 -------CELSCRTQCAPKLCC 437



 Score = 55.2 bits (127), Expect = 2e-06
 Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 33  SHFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRL 92
           S  T+S  +L D+ H L  ++ L+  L++ ++    + T +     NTFGW R EV+G L
Sbjct: 28  SRITSSLAMLSDSFHMLSDVIALVVALVAVRFAEQTQSTNK-----NTFGWIRAEVMGAL 82

Query: 93  SVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG 148
              V   +    +++ A++     +       P V++G   +GLL N +   L  G
Sbjct: 83  VNAVFLTALCFTIILEAIE---RFTEPHEIEQPWVVIGVGALGLLVNLLGLCLFHG 135


>UniRef50_Q5GR56 Cluster: Zinc transporter 1; n=1; Glomus
           intraradices|Rep: Zinc transporter 1 - Glomus
           intraradices
          Length = 454

 Score = 87.4 bits (207), Expect = 4e-16
 Identities = 41/129 (31%), Positives = 74/129 (57%), Gaps = 1/129 (0%)

Query: 148 GSLFVIAAGLTEEWEHEASRI-ADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           G++ V+ +GL     H + R   DP  S    I++++   P ++SA  +LLQ VP GL  
Sbjct: 255 GNIGVVCSGLFIYLTHFSWRFYIDPLTSLILTIIILMSAIPLVKSASFILLQKVPSGLPI 314

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIG 266
            D+R+    + GV ++HELH+WQL   K + + H++     +Y++ +A +  +   HG+ 
Sbjct: 315 DDVRSRIKELYGVLSVHELHIWQLSDTKRICSVHILLAPSANYMEIAADIRKILHVHGVH 374

Query: 267 LVTLQPEFM 275
            +T+QPE++
Sbjct: 375 SITIQPEYV 383



 Score = 42.3 bits (95), Expect = 0.016
 Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 8/112 (7%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           ++ NS  ++ D+ H L  +  L+  L + K   A   T      + ++GW R EV+G L 
Sbjct: 28  YWINSLAIIADSFHMLNDIFSLVVALYALKL--ASRSTFSS---KYSYGWQRAEVLGALI 82

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
             V   +  L++ + A++        P  + P VI+G    GLL N +  +L
Sbjct: 83  NGVFLMALCLSIFIQAIE---RFFDPPDIKNPVVILGVGCAGLLSNIVGLLL 131


>UniRef50_Q5KK51 Cluster: Di-, tri-valent inorganic cation
           transporter, putative; n=3; Basidiomycota|Rep: Di-,
           tri-valent inorganic cation transporter, putative -
           Cryptococcus neoformans (Filobasidiella neoformans)
          Length = 523

 Score = 86.2 bits (204), Expect = 1e-15
 Identities = 53/167 (31%), Positives = 83/167 (49%), Gaps = 10/167 (5%)

Query: 148 GSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           G++ VI+AGL   + +   +   DP +S     ++     P ++SA  +L+Q VP  +  
Sbjct: 347 GNVGVISAGLVIWFCQGRWTLYFDPGVSLVITCIIFSSALPLVKSASYILMQGVPSHVSL 406

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIG 266
             +R     VPGV ++HELH+WQL    VVA+ HV+     DY+  ++ + +    HGI 
Sbjct: 407 DAVRQCIYEVPGVDSVHELHIWQLSESTVVASVHVMIEAGRDYMVVASGIRERMHSHGIH 466

Query: 267 LVTLQPEFMLTSSRGTEEEKKELIAYGNLGCSCPCVKECTGPRCCEP 313
            VT+QPEF       T+ +  E          CP   +C+G  CC P
Sbjct: 467 SVTIQPEFYCEE---TDPQDTEACL-----IRCP-PGQCSGDTCCPP 504


>UniRef50_UPI0000DB7A0C Cluster: PREDICTED: similar to CG5130-PA,
           isoform A; n=2; Apocrita|Rep: PREDICTED: similar to
           CG5130-PA, isoform A - Apis mellifera
          Length = 511

 Score = 85.0 bits (201), Expect = 2e-15
 Identities = 42/129 (32%), Positives = 71/129 (55%), Gaps = 2/129 (1%)

Query: 148 GSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           G +FVI   +   + +   ++  DP  +  ++I L   +Y +M+ +GL+LLQT+P  +  
Sbjct: 243 GCVFVILVSILVYFTDSGVAKYIDPLFAIISSISLFALSYSYMKESGLILLQTIPNHINI 302

Query: 207 CDLRTAALRV-PGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGI 265
             L+   L   PG+  +H+LH+WQL   K+++T H+I+     Y   +  V   F+  GI
Sbjct: 303 DSLKRELLEAFPGIVNVHDLHIWQLTGQKIISTVHIIFLDPTVYTTITDQVTAFFREMGI 362

Query: 266 GLVTLQPEF 274
             VT+QPEF
Sbjct: 363 TQVTIQPEF 371



 Score = 62.9 bits (146), Expect = 1e-08
 Identities = 30/76 (39%), Positives = 43/76 (56%)

Query: 76  RLRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIG 135
           R++NTFGWARI++V  L   V  ASF  +L+V A+Q  VH  H     +P  ++     G
Sbjct: 110 RMKNTFGWARIDIVTMLVCCVFLASFCFSLLVEAMQTLVHIDHLDEMHHPLPVLTIGACG 169

Query: 136 LLFNAINYMLLAGSLF 151
           +  NA  Y+L+ G  F
Sbjct: 170 IFLNAFCYILIGGYTF 185



 Score = 40.7 bits (91), Expect = 0.049
 Identities = 20/70 (28%), Positives = 29/70 (41%)

Query: 1  MAMKEWLQWXXXXXXXXXXXXXXXXXXXXXXXSHFTNSPTLLVDTCHSLCRLVGLITTLI 60
          MA+KEW +                        SH T+S TLL++  H LC ++ L+  + 
Sbjct: 1  MAVKEWFRRLQPVQLYLVLFFTTAFFLVEIVASHVTHSLTLLLNAYHMLCNIIALVGCIA 60

Query: 61 SFKYERADEG 70
          S KY     G
Sbjct: 61 SIKYSHRQNG 70


>UniRef50_A4R597 Cluster: Putative uncharacterized protein; n=1;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 309

 Score = 83.4 bits (197), Expect = 7e-15
 Identities = 41/112 (36%), Positives = 64/112 (57%), Gaps = 2/112 (1%)

Query: 164 EASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIH 223
           EA   ADPA+S   AI++ V   P +R +G +LLQ+VP GL   D+     ++PGV ++H
Sbjct: 137 EARFYADPAISTFIAIMIFVTAVPLVRKSGEILLQSVPVGLSPSDVTHDLEKIPGVDSVH 196

Query: 224 ELHVWQLHRDKVVATAHVIYGTH--EDYLKNSALVCDVFKRHGIGLVTLQPE 273
            LH+W+L + K VA+ HV+       D++  +  V +    +GI    +QPE
Sbjct: 197 HLHIWRLDQTKTVASVHVVVQDEAISDFMTKARTVTECLHAYGIHTAIIQPE 248


>UniRef50_P20107 Cluster: Zinc/cadmium resistance protein; n=7;
           Saccharomycetales|Rep: Zinc/cadmium resistance protein -
           Saccharomyces cerevisiae (Baker's yeast)
          Length = 442

 Score = 81.8 bits (193), Expect = 2e-14
 Identities = 49/150 (32%), Positives = 77/150 (51%), Gaps = 4/150 (2%)

Query: 148 GSLFVIAAGLTEEWEHEAS--RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           G++ VIAA L   W+ E S    +DP +S    I++     P  R A  +LLQ  P  + 
Sbjct: 245 GNIGVIAAALFI-WKTEYSWRYYSDPIVSLIITIIIFSSALPLSRRASRILLQATPSTIS 303

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV-IYGTHEDYLKNSALVCDVFKRHG 264
           A  ++   L VPGV A+H+ HVW L     +A+ HV I    + ++ ++ L+  +F +HG
Sbjct: 304 ADQIQREILAVPGVIAVHDFHVWNLTESIYIASIHVQIDCAPDKFMSSAKLIRKIFHQHG 363

Query: 265 IGLVTLQPEFMLTSSRGTEEEKKELIAYGN 294
           I   T+QPEF+          +  +IA G+
Sbjct: 364 IHSATVQPEFVSGDVNEDIRRRFSIIAGGS 393



 Score = 41.9 bits (94), Expect = 0.021
 Identities = 27/112 (24%), Positives = 52/112 (46%), Gaps = 8/112 (7%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           + ++S  L+ D+ H L  ++ L+  L +      D    R    + T+GW R E++G L 
Sbjct: 28  YMSHSLALIADSFHMLNDIISLLVALWA-----VDVAKNRGPDAKYTYGWKRAEILGALI 82

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
             V   +   ++++ ALQ  +        + PR+++   V GL+ N +   L
Sbjct: 83  NAVFLIALCFSIMIEALQRLIEPQE---IQNPRLVLYVGVAGLISNVVGLFL 131


>UniRef50_A7TP59 Cluster: Putative uncharacterized protein; n=1;
           Vanderwaltozyma polyspora DSM 70294|Rep: Putative
           uncharacterized protein - Vanderwaltozyma polyspora DSM
           70294
          Length = 437

 Score = 81.4 bits (192), Expect = 3e-14
 Identities = 43/144 (29%), Positives = 71/144 (49%), Gaps = 1/144 (0%)

Query: 152 VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRT 211
           +IAA    + ++      DP +S    I++     P  R A  +LLQ  P  + A  ++ 
Sbjct: 248 IIAALFIWKTDYSWKYYTDPIVSLVITIIIFSSALPLSRKASKILLQATPSTISADSVQR 307

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHV-IYGTHEDYLKNSALVCDVFKRHGIGLVTL 270
             L +PGV ++H+LH+W L     +A+ HV +  T + +   + L+ DVF  + I   T+
Sbjct: 308 DILAIPGVISVHDLHIWNLTESVFIASVHVQVDSTPDKFTTVAKLIRDVFHNYNIHSATV 367

Query: 271 QPEFMLTSSRGTEEEKKELIAYGN 294
           QPEF   +    +  K  L+A GN
Sbjct: 368 QPEFASGNVTSEQSRKFSLLAGGN 391



 Score = 37.9 bits (84), Expect = 0.35
 Identities = 25/112 (22%), Positives = 50/112 (44%), Gaps = 8/112 (7%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           + ++S  L+ D+ H L  ++ LI  L +    +      R    + T+GW R E++G L 
Sbjct: 27  YLSHSLALIADSFHMLNDIISLIVALWAVNVAK-----NRSPDAKYTYGWKRAEILGALI 81

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
             V   +   ++++ ALQ  +          P++++     GL+ N +   L
Sbjct: 82  NAVFLMALCFSILIEALQRLIEPQE---INNPKLVLYVGCAGLISNIVGLFL 130


>UniRef50_Q7S9J7 Cluster: Putative uncharacterized protein
           NCU07709.1; n=1; Neurospora crassa|Rep: Putative
           uncharacterized protein NCU07709.1 - Neurospora crassa
          Length = 228

 Score = 80.6 bits (190), Expect = 5e-14
 Identities = 39/124 (31%), Positives = 75/124 (60%), Gaps = 2/124 (1%)

Query: 152 VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRT 211
           ++AA L    + EA   ADP +    AI++++ + P ++++G +LL++ P+G+   D++ 
Sbjct: 11  IVAALLIWLLKSEARFYADPGVGVGIAIMIILSSVPLIKNSGEILLESAPKGVRTDDIKH 70

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTH--EDYLKNSALVCDVFKRHGIGLVT 269
              +VPGV +IHELHVW+L ++K +A+ HV+       +++  +  + +    +GI   T
Sbjct: 71  DIEKVPGVDSIHELHVWRLDQNKAIASVHVVLTEDGIVNFMDKARTIGECLHAYGIHSAT 130

Query: 270 LQPE 273
           +QPE
Sbjct: 131 VQPE 134


>UniRef50_Q2H0R9 Cluster: Putative uncharacterized protein; n=1;
           Chaetomium globosum|Rep: Putative uncharacterized
           protein - Chaetomium globosum (Soil fungus)
          Length = 336

 Score = 80.2 bits (189), Expect = 7e-14
 Identities = 51/174 (29%), Positives = 89/174 (51%), Gaps = 15/174 (8%)

Query: 115 HSSHGP-PPRYPRVIVGSA--VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADP 171
           H+ H P PP     ++G+   V G   N    ++ A  ++++ A     +       ADP
Sbjct: 136 HTQHTPHPPGRDLGMLGALLHVAGDALNNAGVIMAAAVMWLVPAAARGRF------YADP 189

Query: 172 ALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLH 231
           A+    A+ ++    P +R +G +LLQ+ P G+   D++     VPGV ++HELH+W+L 
Sbjct: 190 AVGLAIALTVLATAVPLLRRSGEILLQSAPVGVRLGDVKADMESVPGVVSVHELHIWRLD 249

Query: 232 RDKVVATAHVIY---GTHED---YLKNSALVCDVFKRHGIGLVTLQPEFMLTSS 279
           + K +A+AHV+    G   D   +   + ++ +    +GI  VTLQPE +  +S
Sbjct: 250 QHKAIASAHVVVSGPGVGADLAGFAVQARIIRECLHAYGIHSVTLQPELLPPAS 303


>UniRef50_UPI0000D55EC2 Cluster: PREDICTED: similar to CG5130-PA,
           isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
           similar to CG5130-PA, isoform A - Tribolium castaneum
          Length = 473

 Score = 78.6 bits (185), Expect = 2e-13
 Identities = 41/129 (31%), Positives = 70/129 (54%), Gaps = 2/129 (1%)

Query: 148 GSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           G +FVI   L   + +   ++  DP LS  +A  L+  +YP M+ + L+LLQT+P+ +  
Sbjct: 254 GCVFVIICALIVYFTDKHIAKYVDPILSLVSAGSLLFLSYPHMKESCLILLQTIPDSINI 313

Query: 207 CDLRTAAL-RVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGI 265
             L+   +   P +  +H+ HVWQL   K+++T H+I+   + Y      + +    +GI
Sbjct: 314 DVLKKDLISHFPDIVNVHDFHVWQLTATKIISTVHIIFENQKSYNTIMDDIKEFLIDNGI 373

Query: 266 GLVTLQPEF 274
             VT+QPEF
Sbjct: 374 TQVTIQPEF 382



 Score = 64.1 bits (149), Expect = 5e-09
 Identities = 36/103 (34%), Positives = 54/103 (52%), Gaps = 2/103 (1%)

Query: 73  REGRLRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSA 132
           +E +L+NTFGWARI+V+  L   +  AS + ++ V ALQ  VH  H     +P  ++   
Sbjct: 118 QESKLKNTFGWARIDVISLLICCIFMASLSFSVFVEALQTLVHIDHLDEMHHPLSVLFIG 177

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGL--TEEWEHEASRIADPAL 173
             GLL N + Y+L+ G  F   + L  TE  +    R+  P L
Sbjct: 178 AAGLLLNGVCYLLIGGYTFHQGSFLYVTESGDVVLDRVVVPDL 220



 Score = 33.5 bits (73), Expect = 7.5
 Identities = 18/69 (26%), Positives = 28/69 (40%)

Query: 1  MAMKEWLQWXXXXXXXXXXXXXXXXXXXXXXXSHFTNSPTLLVDTCHSLCRLVGLITTLI 60
          M +KEW +                        SH T++ TLL+D+ H LC ++ L   +I
Sbjct: 10 MPVKEWFRSLQPIQLYVILILTVMFFITELIFSHITHALTLLMDSYHMLCNILALTGCII 69

Query: 61 SFKYERADE 69
          + K     E
Sbjct: 70 TIKNSNRKE 78


>UniRef50_Q54T06 Cluster: Cation efflux family protein; n=1;
           Dictyostelium discoideum AX4|Rep: Cation efflux family
           protein - Dictyostelium discoideum AX4
          Length = 573

 Score = 77.8 bits (183), Expect = 4e-13
 Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 9/166 (5%)

Query: 149 SLFVIAAGLTEEWEH-EASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGAC 207
           SLFV+  G    + H + +   DPA+S    I++   + P ++   ++LLQ VP+ +   
Sbjct: 391 SLFVLITGAVIHFTHGKWTEYIDPAVSLIIVIMIAATSAPLVKRCSMILLQKVPDDIDLD 450

Query: 208 DLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGL 267
            +R    +V GV + H+LHVWQL     +A+ HV      ++   ++ +  +F + GI  
Sbjct: 451 SIRYKIAKVEGVVSQHDLHVWQLVDGMTIASVHVGIEQGREFQSIASKLRKIFHKEGIHS 510

Query: 268 VTLQPEFM-LTSSRGTEEEKKELIAYGNLGCSCPCVKECTGPRCCE 312
            ++QPEF+ + S  G               C   CV +C    CC+
Sbjct: 511 TSIQPEFLPINSFTGGATSDPNF-------CIQNCVDDCEEEWCCK 549


>UniRef50_UPI000069F760 Cluster: solute carrier family 30 (zinc
           transporter), member 10; n=1; Xenopus tropicalis|Rep:
           solute carrier family 30 (zinc transporter), member 10 -
           Xenopus tropicalis
          Length = 385

 Score = 77.0 bits (181), Expect = 6e-13
 Identities = 42/142 (29%), Positives = 69/142 (48%), Gaps = 13/142 (9%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP+L+     +++   +P ++    +LLQ VP+G+   ++      VPGV ++HE+H+W+
Sbjct: 256 DPSLTVVMVAIILYSAFPLIKETAYILLQMVPQGVQVGEIGQKLALVPGVNSVHEIHIWE 315

Query: 230 LHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKEL 289
           L   K +AT HV +     +   S  +  +F    I  VT+Q EF           +K+L
Sbjct: 316 LASGKNIATLHVKFQDFASHATASQEIRRIFHEEEIHAVTIQAEF---------PNEKDL 366

Query: 290 IAYGNLGCSCPCVKECTGPRCC 311
                L CS PC+ E   P  C
Sbjct: 367 ----TLACSAPCISEKCDPYLC 384


>UniRef50_O13918 Cluster: Zinc homeostasis factor 1; n=1;
           Schizosaccharomyces pombe|Rep: Zinc homeostasis factor 1
           - Schizosaccharomyces pombe (Fission yeast)
          Length = 387

 Score = 76.6 bits (180), Expect = 8e-13
 Identities = 44/132 (33%), Positives = 72/132 (54%), Gaps = 5/132 (3%)

Query: 148 GSLFVIAAGLTEEWEHEASR-IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           G++ VI+A L  ++   + R + DP +S     +++    P  +SA L+LLQ  P+ +  
Sbjct: 243 GNIGVISAALFIKYTDYSWRFLFDPCISILLTFIILFSAIPLCKSAALILLQVAPQSIKL 302

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED----YLKNSALVCDVFKR 262
            D+      + GV ++HELH+WQL   K++AT HV     +D    Y K +  + +V + 
Sbjct: 303 DDVSNLINHLDGVESVHELHIWQLSDVKLIATVHVCVTLPDDKGESYTKLTTDIRNVLQS 362

Query: 263 HGIGLVTLQPEF 274
            GI  VT+QPEF
Sbjct: 363 FGIYDVTIQPEF 374



 Score = 36.7 bits (81), Expect = 0.80
 Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  +V L+  L +    R    T  E +   T+GW R E++G LS  V
Sbjct: 32  DSLALIADSFHMLNDIVSLLVALWA---TRLAHSTSHEPKY--TYGWQRAEILGALSNGV 86

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +  + + + A++  +     P    P ++     +GLL N +   L
Sbjct: 87  FLIALCMFIFMEAIERFIEP---PSVSNPTLMFFVGSLGLLSNFVGIFL 132


>UniRef50_A2FW10 Cluster: Cation efflux family protein; n=4;
           Trichomonas vaginalis G3|Rep: Cation efflux family
           protein - Trichomonas vaginalis G3
          Length = 438

 Score = 75.4 bits (177), Expect = 2e-12
 Identities = 71/269 (26%), Positives = 117/269 (43%), Gaps = 30/269 (11%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           T S +L  D  H L     L+  LI+  +E+A     R    + TFG AR EV+G  +  
Sbjct: 92  TKSLSLQSDAWHMLSDEASLVIGLIA--HEKAK----RPPTDKYTFGLARSEVIGGFTNS 145

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL--------- 146
           V   +  L ++  A++  +       P    +IVG   +GLL N I   +          
Sbjct: 146 VFLLAVCLTILFEAIERFIKVEEIVEP-LALLIVGG--LGLLVNFIGMFIFHNHSHSDNL 202

Query: 147 -----------AGSLFVIAAGLTEEWEHEASRI-ADPALSACAAIVLVVFNYPFMRSAGL 194
                       GS+ V  +     W     R   DPA S     +L+  +   +R  G 
Sbjct: 203 KGVFLHITGDFLGSVAVCISACVCLWTKWEGRFYLDPACSILIFCILIYGSQNLLRRTGS 262

Query: 195 VLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSA 254
           VLL+T P G+    ++   +++ G+ A+HELHVW+L +++ +A  H++  + +   K   
Sbjct: 263 VLLETCPPGVDVNSMKIDLMKIEGMVAVHELHVWELCKERYLALLHIVVDSKDRNKKVLE 322

Query: 255 LVCDVFKRHGIGLVTLQPEFMLTSSRGTE 283
              +V   H I   T+Q EF+    +GT+
Sbjct: 323 QTHNVMIAHKIFSTTVQIEFVDDFPQGTD 351


>UniRef50_A4QRA6 Cluster: Putative uncharacterized protein; n=2;
           Sordariomycetes|Rep: Putative uncharacterized protein -
           Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 532

 Score = 72.1 bits (169), Expect = 2e-11
 Identities = 53/179 (29%), Positives = 78/179 (43%), Gaps = 16/179 (8%)

Query: 148 GSLFVIAAGLTEEWEHEASR--IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           G++ VI   L   W+ E S    ADPA+S     +++    P   +   +LLQ  P+ + 
Sbjct: 323 GNVGVIVTALII-WKTEWSGRFYADPAVSLFITCIILRSCIPLTLATAKILLQATPDHIS 381

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYG------THEDYLKNSALVCDV 259
             D++     +PGV + H +H+WQL   K+VA+ H+           E Y+K +      
Sbjct: 382 IRDIKADIQDLPGVVSCHHVHIWQLSDTKLVASMHIQVSFPISEEGGEKYMKLAMRARSC 441

Query: 260 FKRHGIGLVTLQPEFMLTS---SRGTEEEKKELIAYGNLG----CSCPCVKECTGPRCC 311
              +GI   T+QPEF L     SR          A G  G    C   CV +C G  CC
Sbjct: 442 LHAYGIHSATIQPEFYLDDVHLSRSDIAASDAATACGTGGPGSVCLLECVDDCVGQGCC 500


>UniRef50_Q75D95 Cluster: ABR129Cp; n=2; Saccharomycetaceae|Rep:
           ABR129Cp - Ashbya gossypii (Yeast) (Eremothecium
           gossypii)
          Length = 423

 Score = 71.7 bits (168), Expect = 2e-11
 Identities = 50/187 (26%), Positives = 87/187 (46%), Gaps = 11/187 (5%)

Query: 115 HSSHGPPPRYPRVI-VGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPAL 173
           HS+HG   R   +  V   V+G     +  ML A  +F+     +  W +     +DP +
Sbjct: 203 HSAHGADHRSLNMHGVFLHVLGDALGNVGVMLTA--IFIWKTDYS--WRY----YSDPFV 254

Query: 174 SACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRD 233
           S     ++     P  R A  +LLQ  P  + A +++   L +P   ++H+ H+W L   
Sbjct: 255 SLVITCIIFSSALPLSRKASRILLQATPSSISADEIKGKILAIPVAISVHDFHIWNLTET 314

Query: 234 KVVATAHVIYGTHED-YLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKK-ELIA 291
             +A+ HV     +D Y+  + ++  +F R+GI   T+QPEF+ +     +  ++   IA
Sbjct: 315 FSIASIHVQVDCGQDSYIGTAKVIRSIFHRYGIHSATVQPEFIGSRDVSDDSYRRFSRIA 374

Query: 292 YGNLGCS 298
            G LG S
Sbjct: 375 GGGLGSS 381



 Score = 38.7 bits (86), Expect = 0.20
 Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  +V LI  L +    +      R    R T+GW R E++G L   V
Sbjct: 31  HSLALIADSFHMLNDIVSLIVALWAVNVAKT-----RNPDARYTYGWKRAEILGALINAV 85

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +  +++++ A+Q           + P++I+     GLL N +   L
Sbjct: 86  FLIALCVSILIEAIQRFFEPQE---VKNPQLILYVGTAGLLSNILGLFL 131


>UniRef50_A1DI13 Cluster: Zinc/cadmium resistance protein; n=8;
           Pezizomycotina|Rep: Zinc/cadmium resistance protein -
           Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
           181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
           3700 / NRRL 181))
          Length = 534

 Score = 70.9 bits (166), Expect = 4e-11
 Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 6/111 (5%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +S    ++++    P  ++A  +LLQ VP GL    ++    R+PGV   H LHVWQ
Sbjct: 361 DPGISLVITVIILASAIPLCKAASRILLQAVPAGLSIDHIKEDIERLPGVIGSHHLHVWQ 420

Query: 230 LHRDKVVATAHVIYGTH------EDYLKNSALVCDVFKRHGIGLVTLQPEF 274
           L   K+VA+ H+   T       E Y++ +  V      +GI   T+QPEF
Sbjct: 421 LSDTKLVASIHIQVDTEIKGEGSERYMRLARQVRKCLHAYGIHSSTIQPEF 471



 Score = 35.5 bits (78), Expect = 1.9
 Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  ++ L+  L + K   A++ T  +     T+GW R E +G L   V
Sbjct: 31  HSLALVADSFHMLNDVISLLVGLWAVKV--ANQETKSK---MYTYGWQRAETLGALVNGV 85

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +  L++ + A+Q  V        + P+++     +GLL N +  +L
Sbjct: 86  FLVALCLSIFLEAIQRLVEPQE---VKNPKLVCIVGCLGLLSNILGLLL 131


>UniRef50_UPI0000E49D68 Cluster: PREDICTED: similar to CG17723-PA
           isoform 1; n=3; Strongylocentrotus purpuratus|Rep:
           PREDICTED: similar to CG17723-PA isoform 1 -
           Strongylocentrotus purpuratus
          Length = 457

 Score = 70.5 bits (165), Expect = 5e-11
 Identities = 39/130 (30%), Positives = 66/130 (50%), Gaps = 2/130 (1%)

Query: 148 GSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           GS+ VI + L   + + +     DP LS    I++    +P  + + ++LLQ++P G+  
Sbjct: 207 GSVVVIISALVVMFADGDWVFCVDPVLSILIVIIISTTTWPLFKQSSMILLQSIPTGIDI 266

Query: 207 CDL-RTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGI 265
            D+ +        +  IHE HVWQL   K++AT H+   + E+Y K       +  + GI
Sbjct: 267 EDIDKKLREECSYIDNIHEFHVWQLTGSKLIATLHISVSSLEEYGKVIEQATKILHQEGI 326

Query: 266 GLVTLQPEFM 275
              T+QPEF+
Sbjct: 327 HSTTIQPEFI 336



 Score = 50.8 bits (116), Expect = 5e-05
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 10/114 (8%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           + T+S  L+ D+ H L  ++ LI   ++ +Y + D         +NT+GW R EVVG L 
Sbjct: 28  YITHSLALVADSFHMLSDIIALIVGFVAVRYAKRDTP-------KNTYGWQRAEVVGALV 80

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA 147
             V   +    ++V+A++  V       PR   ++ G   +GL  N +  +L +
Sbjct: 81  NAVFLFALCFTILVDAIERLVQGDKIKDPRLVLIVGG---VGLAVNLLGILLFS 131


>UniRef50_UPI000049966E Cluster: cation diffusion facilitator family
           transporter; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
           cation diffusion facilitator family transporter -
           Entamoeba histolytica HM-1:IMSS
          Length = 439

 Score = 70.5 bits (165), Expect = 5e-11
 Identities = 50/173 (28%), Positives = 80/173 (46%), Gaps = 9/173 (5%)

Query: 148 GSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           GS+  +A  L   + + +     DP+LS   A V++    P + S   +L+Q VP+ +  
Sbjct: 269 GSIVAVAVALCVWFIDGDWKYYLDPSLSVIVACVIICSGTPLVYSCVKILMQRVPQNVSI 328

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCD---VFKRH 263
             L+   L V GV +IHE H+WQL  +  +AT H ++   +D  +   +V D   VF ++
Sbjct: 329 KKLKRDILAVNGVDSIHEFHLWQLANETNIATIH-LFLNEDDRCRVMEIVQDVKNVFHKY 387

Query: 264 GIGLVTLQPEFMLTSSRGTEEEKKELIAYGNLGCSCPCVKECTGPRCCEPPNI 316
           G+   T+Q E  +    G E     +         CP   EC    CC+ P I
Sbjct: 388 GVHSTTIQTELGVI---GEENGHDSVGVSRRCLIGCPS-DECKNDVCCKQPII 436



 Score = 33.9 bits (74), Expect = 5.7
 Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 9/109 (8%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  LL D  H L  L+  +  L +    +      ++   R T+G+ R EVVG L   V
Sbjct: 84  HSLALLADAFHMLSDLLSQVIGLGAILLAK------KKASKRLTYGFVRAEVVGALINGV 137

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              S A  +++ A+Q  +       P+   ++   A +GL  N    +L
Sbjct: 138 FLLSVAFFIIIEAIQRFIDIEEITQPKIMLIV---AAVGLFINLAAMLL 183


>UniRef50_Q2HFW8 Cluster: Putative uncharacterized protein; n=2;
           Sordariomycetes|Rep: Putative uncharacterized protein -
           Chaetomium globosum (Soil fungus)
          Length = 553

 Score = 69.7 bits (163), Expect = 9e-11
 Identities = 41/140 (29%), Positives = 64/140 (45%), Gaps = 6/140 (4%)

Query: 169 ADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVW 228
           ADPA+S    ++++    P   +A  +LLQ  PE +   D+R     +PGV + H +H+W
Sbjct: 360 ADPAVSLFITLIILRSCIPLTIAASKILLQATPEHIDLNDVREDIQALPGVISCHHVHIW 419

Query: 229 QLHRDKVVATAH------VIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGT 282
           QL   KVVA+ H      +     E Y++ S +       +GI   T+QPEF L  +   
Sbjct: 420 QLSDTKVVASMHIQVAFPISEAGGEKYMELSMMARKCLHAYGIHSATIQPEFCLDRAHAH 479

Query: 283 EEEKKELIAYGNLGCSCPCV 302
             E    +       S P +
Sbjct: 480 ARELDSAMRMDGASASSPAL 499


>UniRef50_Q5BCD5 Cluster: Putative uncharacterized protein; n=1;
           Emericella nidulans|Rep: Putative uncharacterized
           protein - Emericella nidulans (Aspergillus nidulans)
          Length = 500

 Score = 68.9 bits (161), Expect = 2e-10
 Identities = 46/160 (28%), Positives = 66/160 (41%), Gaps = 18/160 (11%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +S    ++++    P  ++A  +LLQ VP GL    ++     +PGV   H LHVWQ
Sbjct: 336 DPGISLVITVIILASAIPLCKAASRILLQAVPHGLSIDHIKEDIESLPGVKGSHHLHVWQ 395

Query: 230 LHRDKVVATAHVIYGTH------EDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTE 283
           L   K VA+ H+   T       E Y+  +  V      +GI   T+QPEF   S     
Sbjct: 396 LSDTKTVASIHIQVDTEIKGEGSERYMHLAKQVRQCLHAYGIQSSTIQPEFPRDSDTEDN 455

Query: 284 EEKKELIAYGN------------LGCSCPCVKECTGPRCC 311
           +     +  G+              C   C  EC G  CC
Sbjct: 456 QVGSAHLPSGSPSRTPSIRDGDPQACLLECGDECAGGHCC 495



 Score = 39.5 bits (88), Expect = 0.11
 Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  ++ L+  L + K   A+  T  +     T+GW R E +G L   V
Sbjct: 31  HSLALVADSFHMLNDVISLLVGLWAVKV--ANRETSSK---MYTYGWQRAETLGALVNGV 85

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              + +L++ + A+Q  V        R P+++ G    GLL N +  +L
Sbjct: 86  FLVALSLSIFLEAIQRLVEPQE---VRNPKLVCGVGCAGLLSNILGLVL 131


>UniRef50_A5ABY7 Cluster: Function: Zinc-replete cells accumulate
           zinc in the vacuole via the Zrc1p precursor; n=2;
           Ascomycota|Rep: Function: Zinc-replete cells accumulate
           zinc in the vacuole via the Zrc1p precursor -
           Aspergillus niger
          Length = 431

 Score = 68.1 bits (159), Expect = 3e-10
 Identities = 42/134 (31%), Positives = 66/134 (49%), Gaps = 7/134 (5%)

Query: 148 GSLFVIAAGLTEEWEHEASRI-ADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           G++ VIA+ L       + R   DP +S    +++++   P  ++A  +LLQ  P GL  
Sbjct: 234 GNIGVIASALIIWLTDYSWRFYVDPGISLVITVIILLSAIPLCKAASRILLQAAPHGLSI 293

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTH------EDYLKNSALVCDVF 260
             ++     +PGV   H LHVWQL   K+VA+ H+   T       E Y++ +  V    
Sbjct: 294 DHIKEDIEGLPGVIGSHHLHVWQLSDTKLVASIHIQVDTEIKGEGSERYMRLARQVRKCL 353

Query: 261 KRHGIGLVTLQPEF 274
             +GI   T+QPEF
Sbjct: 354 HAYGIHSSTIQPEF 367



 Score = 35.5 bits (78), Expect = 1.9
 Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  ++ L   L + K   A+  T  +     T+GW R E +G L   V
Sbjct: 31  HSLALVADSFHMLNDVLSLCVGLWAVKV--ANRETNSK---MYTYGWQRAETLGALVNGV 85

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +  L++ + A+Q  V       P++   IVG   +GLL N I  +L
Sbjct: 86  FLVALCLSIFLEAIQRLVEPQEVKNPKFV-CIVG--CLGLLSNIIGLVL 131


>UniRef50_A1D9L0 Cluster: Di-, tri-valent inorganic cation
           transporter, putative; n=2; Trichocomaceae|Rep: Di-,
           tri-valent inorganic cation transporter, putative -
           Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
           181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
           3700 / NRRL 181))
          Length = 345

 Score = 67.7 bits (158), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 79/155 (50%), Gaps = 5/155 (3%)

Query: 120 PPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEW-EHEASRIADPALSACAA 178
           PP R         ++G+L + I   +   +L V+ A L   + E+E    ADP  S   A
Sbjct: 177 PPKRTGSSCRDVGMLGVLLHVIGDAV--NNLGVMIAALVIWFTEYEGRYYADPGASLWIA 234

Query: 179 IVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVAT 238
            ++++ + P +R  G +LL   P G+   DLR+   ++ GV +IHE++VW + + K +A 
Sbjct: 235 FIIILSSLPLLRKTGSILLGCAPSGIDLNDLRSDLEKIQGVLSIHEINVWHISQHKSLAV 294

Query: 239 AHVIYGTHE--DYLKNSALVCDVFKRHGIGLVTLQ 271
             V+        + K +++V +  +++GI  V L+
Sbjct: 295 IGVLVTDQHVPGFTKLTSMVNECCQKYGIQSVALR 329



 Score = 34.7 bits (76), Expect = 3.2
 Identities = 20/85 (23%), Positives = 43/85 (50%), Gaps = 7/85 (8%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           +T+S  L+ D  H L  L+G +  L++ K    D+      ++   FGW R  ++G    
Sbjct: 31  YTHSLALVADAFHYLTDLIGFVVALLALKLSEIDDPP----KIL-AFGWQRAPLLGAFFN 85

Query: 95  HVLFASFALALVVNALQ--LGVHSS 117
             L  +  +++++ A++  + +H+S
Sbjct: 86  GALLFALGISILLQAVERFISLHNS 110


>UniRef50_Q7QZ17 Cluster: GLP_464_49476_50732; n=1; Giardia lamblia
           ATCC 50803|Rep: GLP_464_49476_50732 - Giardia lamblia
           ATCC 50803
          Length = 418

 Score = 67.3 bits (157), Expect = 5e-10
 Identities = 32/98 (32%), Positives = 52/98 (53%), Gaps = 1/98 (1%)

Query: 146 LAGSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGL 204
           L GS+  I + L +++  H  + + DP  +    I++V    P ++S   +LLQ +PEGL
Sbjct: 249 LMGSVVAIVSALVQKFVTHPLAHLVDPMTTMLMVIIIVCAAVPLLKSTIRILLQAIPEGL 308

Query: 205 GACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
               L+   L V GV  +H+LHVW    + V+   HV+
Sbjct: 309 SLDVLKERVLDVDGVLGVHDLHVWTFTDETVIGHCHVV 346



 Score = 38.3 bits (85), Expect = 0.26
 Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 7/103 (6%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           NS TL+ D  H L  L+ L+  LIS    R      ++   + TFG+ R E +G      
Sbjct: 50  NSLTLVGDAFHMLSDLLSLVIGLISLVLGR------KQASAQATFGYKRSETIGGFFNAS 103

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN 139
              S A  LV  A+Q  + ++ G    +  +++G A+ GL+ N
Sbjct: 104 FLLSTAFFLVTEAVQKLI-TAEGVDLNHIDLVLGVAIGGLVVN 145


>UniRef50_Q7MUS7 Cluster: Heavy metal efflux pump, CzcD family; n=1;
           Porphyromonas gingivalis|Rep: Heavy metal efflux pump,
           CzcD family - Porphyromonas gingivalis (Bacteroides
           gingivalis)
          Length = 321

 Score = 66.1 bits (154), Expect = 1e-09
 Identities = 60/227 (26%), Positives = 108/227 (47%), Gaps = 29/227 (12%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRN-TFGWARIEVVGRLS 93
           FT S  +L D  H     + L    I+++ ++  E    +GR R+ ++G+ R  ++G L 
Sbjct: 60  FTGSVAILSDALHDFGDSISLG---IAWRLQKLSE----KGRDRSFSYGYKRFSLLGALL 112

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFV- 152
           + ++    ++ +++ A+Q    S  G P     +I+  A+ GL+ N +  + L GS  + 
Sbjct: 113 ISIILLVGSVFVIIAAVQR--FSMPGEPKAGGMLIL--AIFGLVVNGLAALRLKGSSSLN 168

Query: 153 ---IAAGLTEE---WEHEA----------SRIADPALSACAAIVLVVFNYPFMRSAGLVL 196
              +   L E+   W              + I DP LS C    ++   Y  +R    VL
Sbjct: 169 ERAVMLHLLEDVLGWAAVLVVSIVMLFVNAPILDPILSLCITAWILYNVYGNLRETFKVL 228

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIY 243
           LQ VP+G+    L+T  L +P + ++H++H+W L  +  V T HV+Y
Sbjct: 229 LQGVPDGIDLEGLKTDILSLPHIRSVHDIHLWTLDGESHVMTIHVVY 275


>UniRef50_Q2PIQ1 Cluster: Zn2+ transporter ZNT1 and related
           Cd2+/Zn2+ transporters; n=1; Aspergillus oryzae|Rep:
           Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters
           - Aspergillus oryzae
          Length = 443

 Score = 65.7 bits (153), Expect = 2e-09
 Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 22/145 (15%)

Query: 189 MRSAGLVLLQTVPEGLGACDLR---------------TAALRVPGVFAIHELHVWQLHRD 233
           +R +GL+LL++ P GL   D++                 A+ VPGV AIHELH+W+L+++
Sbjct: 298 VRRSGLILLESAPNGLDPADVKHDLEKARTNASGATSREAILVPGVLAIHELHIWRLNQN 357

Query: 234 KVVATAHVIYG--THEDYLKNSALVCDVFKRHGIGLVTLQPEF-----MLTSSRGTEEEK 286
           K +A+ HV+    +  ++ K +  + + F  +GI   TLQPE      ++ +   + E  
Sbjct: 358 KTLASVHVVVSDPSVTNFAKTTKTINECFHAYGIHSATLQPETCSMAEVICTEHESVETV 417

Query: 287 KELIAYGNLGCSCPCVKECTGPRCC 311
           +EL       C   C   C    CC
Sbjct: 418 QELRKRSLEKCQMMCGTLCEELTCC 442



 Score = 39.1 bits (87), Expect = 0.15
 Identities = 28/121 (23%), Positives = 57/121 (47%), Gaps = 9/121 (7%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRN------TFGWARIEV 88
           +T+S  L+ D  H L  L+G I  L++ +    D       RL +      +FGW R ++
Sbjct: 56  YTHSLALIADAFHYLNDLIGFIVALVALRVGYLDSSQRLHKRLTDDAPKSLSFGWQRAQL 115

Query: 89  VGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG 148
           +G      L  +  +++ + +++  +   +   P+    I+G+  +GL  N I+ + L G
Sbjct: 116 LGAFFNGALLFALGISVFLQSIERFISMQYVENPKL-MFIMGA--VGLGLNLISAIFLHG 172

Query: 149 S 149
           +
Sbjct: 173 A 173


>UniRef50_Q0C865 Cluster: Putative uncharacterized protein; n=1;
           Aspergillus terreus NIH2624|Rep: Putative
           uncharacterized protein - Aspergillus terreus (strain
           NIH 2624)
          Length = 224

 Score = 65.7 bits (153), Expect = 2e-09
 Identities = 35/127 (27%), Positives = 60/127 (47%), Gaps = 3/127 (2%)

Query: 185 NYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYG 244
           N   M +A ++   + P  +    ++    ++PGV AIHELH+W+L++ K +A+ H++  
Sbjct: 88  NLGVMAAALVIWFASAPASIDPLHVQLDLEKIPGVLAIHELHIWRLNQRKTLASVHIVLP 147

Query: 245 THEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSRGTEEEKKELIAYGNLGCSCPCVKE 304
              D+   +  V   F  HGI   TLQPE  +   +   +    ++      C   C + 
Sbjct: 148 EGADWAGTTRAVNGCFHAHGIHSATLQPEIKM---QVQVQMLDGVVVREKEKCRVLCGEV 204

Query: 305 CTGPRCC 311
           C   RCC
Sbjct: 205 CEELRCC 211


>UniRef50_O67168 Cluster: Cation efflux system; n=1; Aquifex
           aeolicus|Rep: Cation efflux system - Aquifex aeolicus
          Length = 308

 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 74/262 (28%), Positives = 112/262 (42%), Gaps = 40/262 (15%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           TNS  LL D  H L   V L   L++ +Y      T R      T+G  R+EV+  L   
Sbjct: 31  TNSLALLSDAGHMLTDAVSLSIALVA-QYLALKVKTKR-----TTYGLYRLEVLAALVNG 84

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN-AINYMLLA------- 147
           V    F L L+   +   +H    P P  P++I   A  GL+ N  + Y+LL        
Sbjct: 85  V----FLLGLIGYIILEAIHRFENPEPVKPQMIY-IAFAGLIVNLVVGYILLKHSEENIN 139

Query: 148 -------------GSLFVIAAGLTEE-WEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                        GS+  I AG+    W+     +ADP LS   A++++   Y  ++   
Sbjct: 140 IKSALLHVATDTLGSVAAIIAGIAIVFWKFY---LADPILSVAVALLILPSAYSVIKETV 196

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNS 253
            VLL+  P  +   +L    L + GV  +H+LHVW +     V T HV+    +  + N 
Sbjct: 197 NVLLEVAPSHINTEELEKELLNLQGVKGVHDLHVWSITPGTEVLTVHVV--VEDTSICND 254

Query: 254 AL--VCDVFKRHGIGLVTLQPE 273
            L  V  +  ++GI   T+Q E
Sbjct: 255 ILKEVEKIAHKYGIKHTTVQLE 276


>UniRef50_A4X1A6 Cluster: Cation diffusion facilitator family
           transporter; n=7; Actinobacteria (class)|Rep: Cation
           diffusion facilitator family transporter - Salinispora
           tropica CNB-440
          Length = 307

 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 80/264 (30%), Positives = 110/264 (41%), Gaps = 41/264 (15%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           T S  LL D  H    ++G+   L +     A     R G+   TFG  R+EV+  L+  
Sbjct: 43  TGSLALLSDAGHMFTDVLGMGMALAAIT---AASKASRAGQ--RTFGLYRMEVLAALANA 97

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA-------- 147
           VL    A  +VV A    V     PP    R +V  AV GLL N + + LL         
Sbjct: 98  VLLFGVASYVVVEA----VRRFGQPPEVLARPMVVVAVAGLLANVVAFFLLRAGSRESLN 153

Query: 148 ---------GSLF-----VIAA---GLTEEWEHEASRIADPALSACAAIVLVVFNYPFMR 190
                    G LF     +IAA    LT+ W       ADP ++    + ++   Y   R
Sbjct: 154 VRGAYLEVLGDLFTSVGVIIAAVVITLTDWW------YADPLIAVVVGLFILPRAYQLGR 207

Query: 191 SAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYL 250
           +A  VL+Q  P  L    +R A L V GV  +H+LHVW L     VA+AH+      D+ 
Sbjct: 208 AALRVLVQAAPVHLDISVVRAAMLGVDGVADVHDLHVWTLTSGMEVASAHLALERDADFA 267

Query: 251 KNSALVCDVFK-RHGIGLVTLQPE 273
              A    + + R  +   TLQ E
Sbjct: 268 AVLATSQRLLRDRFAVEHATLQAE 291


>UniRef50_A3XRG5 Cluster: Cobalt/zinc/cadmium cation efflux pump
           protein; n=7; Bacteria|Rep: Cobalt/zinc/cadmium cation
           efflux pump protein - Leeuwenhoekiella blandensis MED217
          Length = 304

 Score = 64.5 bits (150), Expect = 3e-09
 Identities = 61/261 (23%), Positives = 118/261 (45%), Gaps = 32/261 (12%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  LL D  H+L  ++ LI + I+ +Y + +  T +      TFG+ R E++      
Sbjct: 42  SGSLALLSDAVHNLSDVISLIISYIAQRYSKKEASTHK------TFGYKRAEIIAAF--- 92

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA----GSLF 151
            + A+  + + V  ++  V     P      +++  AV+G++ N ++ +LL     G++ 
Sbjct: 93  -VNAATLIVIAVLLMKEAVERFLNPQAIASDLVIWLAVLGIVANGLSVLLLQKDSKGNMN 151

Query: 152 VIAAGL---TEEWEHEASRIA------------DPALSACAAIVLVVFNYPFMRSAGLVL 196
           + +A L   T+     A  +             D  L+   +I L+V  Y  ++S+  VL
Sbjct: 152 MRSAYLHLLTDMMASVAVLVGGILMYFFKIYWIDSLLTLAISIYLIVMGYGLLKSSFKVL 211

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV 256
           +   PE L   DL     ++  +  IH +H+WQL+ D+V   AH+            A++
Sbjct: 212 MLFSPEDLEIDDLIKEVKQLDAIKNIHHIHIWQLNDDEVHLEAHIDLKNDIKLSAFDAIL 271

Query: 257 CD---VFKRHGIGLVTLQPEF 274
            +   +   +GI  + +QPE+
Sbjct: 272 LEIEHIAMHYGINHINIQPEY 292


>UniRef50_A6SIM4 Cluster: Putative uncharacterized protein; n=2;
           Sclerotiniaceae|Rep: Putative uncharacterized protein -
           Botryotinia fuckeliana B05.10
          Length = 315

 Score = 63.7 bits (148), Expect = 6e-09
 Identities = 30/87 (34%), Positives = 54/87 (62%), Gaps = 2/87 (2%)

Query: 189 MRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV--IYGTH 246
           +++AG ++LQ+VP G+   +++     + G+ +IHELH+W L + K VA+AH+  I    
Sbjct: 198 IKNAGAIMLQSVPSGININNVKHDIENIAGILSIHELHIWSLCQRKTVASAHIVTIETDL 257

Query: 247 EDYLKNSALVCDVFKRHGIGLVTLQPE 273
           + ++K + L+ +    +GI  VTLQ E
Sbjct: 258 KAFMKQAKLIRECLHAYGIHSVTLQAE 284


>UniRef50_A6SSD0 Cluster: Putative uncharacterized protein; n=2;
           Sclerotiniaceae|Rep: Putative uncharacterized protein -
           Botryotinia fuckeliana B05.10
          Length = 569

 Score = 63.3 bits (147), Expect = 8e-09
 Identities = 43/165 (26%), Positives = 71/165 (43%), Gaps = 15/165 (9%)

Query: 169 ADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVW 228
           ADPA+S    I+++    P  ++   +LLQ  P+ +    ++        V   H +H+W
Sbjct: 393 ADPAVSLFITIIILRSCIPLTKATAQILLQATPDSIDVALIKEDIENFDAVKGCHHVHIW 452

Query: 229 QLHRDKVVATAH--VIYGTHED----YLKNSALVCDVFKRHGIGLVTLQPEFML------ 276
           QL   ++VA+ H  V +   ED    Y++ +  + +    HGI   TLQPEF L      
Sbjct: 453 QLSDSQLVASMHIQVAFPIGEDGGEKYMQLAKEIRECLHGHGIHSATLQPEFCLDKDHDH 512

Query: 277 --TSSRGTEEEKKELIAY-GNLGCSCPCVKECTGPRCCEPPNIPP 318
               S G + + +       +  C   C+  C G  CC    + P
Sbjct: 513 IFNGSVGLDGQVQTKCGMEDDDSCLLECIDNCKGKGCCSTQAVEP 557


>UniRef50_Q6NHN1 Cluster: Cation-efflux system integral membrane
           protein; n=1; Corynebacterium diphtheriae|Rep:
           Cation-efflux system integral membrane protein -
           Corynebacterium diphtheriae
          Length = 307

 Score = 62.5 bits (145), Expect = 1e-08
 Identities = 70/263 (26%), Positives = 121/263 (46%), Gaps = 43/263 (16%)

Query: 38  SPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHVL 97
           S  L+ D  H L    GLI  LI+    R      R+   + T+G+ RIEV+  L V+ L
Sbjct: 48  SLALMSDALHMLSDSTGLIIALIAVVIGR------RKATSQATYGYKRIEVLAAL-VNAL 100

Query: 98  FASFALA-LVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL---------- 146
             +F    +V+ A++    SSH        +++  A+IGL+FN +  ++L          
Sbjct: 101 SVTFITGWIVLEAIRR--LSSHTVIDTRTTMVI--AIIGLVFNIVGAVVLHGHSHEGVNV 156

Query: 147 -----------AGSLFVIAAGL---TEEWEHEASRIADPALSACAAIVLVVFNYPFMRSA 192
                       GS+ VI + L   T  W        D A+S   A++++  +   +RS 
Sbjct: 157 KGAYLHILVDLGGSVAVIVSSLLIMTTGWMW-----CDTAVSVLLAVIILPRSLSLVRST 211

Query: 193 GLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKN 252
             +L++ VP+ +    +R+   ++ GV  +H++HVW +   + +AT HV+   + +    
Sbjct: 212 LGILMERVPKTVDVETIRSRIAQIDGVGGVHDVHVWSIDGQQDIATVHVVVDENVNVKDC 271

Query: 253 SAL--VCDVFKRHGIGLVTLQPE 273
           + L  +  VF   GI  VT+Q E
Sbjct: 272 TTLDRIQKVFHDAGIDHVTVQLE 294


>UniRef50_A4XA76 Cluster: Cation diffusion facilitator family
           transporter; n=3; Actinomycetales|Rep: Cation diffusion
           facilitator family transporter - Salinispora tropica
           CNB-440
          Length = 305

 Score = 62.5 bits (145), Expect = 1e-08
 Identities = 62/228 (27%), Positives = 106/228 (46%), Gaps = 34/228 (14%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRL-RNTFGWARIEVVGRLSV 94
           T S TLL D  H    ++G+  +L +         T + G+  + TFG  R+EV+  L+ 
Sbjct: 44  TGSLTLLGDAGHMFTDVLGIGMSLAALTL------TSQRGKNPQRTFGLYRVEVLAALTN 97

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA------- 147
            ++ ++ ++ ++V A++       GPP      ++  AV+GLL N + ++LL        
Sbjct: 98  ALMLSAVSIYVLVEAIR----RFSGPPEVDTGPMLVVAVLGLLANIVAFVLLRPGAKESI 153

Query: 148 --------------GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                         GSL VIAA L         ++ADP ++    +  +   +   R+A 
Sbjct: 154 NLKGAYLEALSDLLGSLSVIAAALIIAGT--GWQLADPLIAVALGLFRLPRIWLLGRAAT 211

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
            +L+Q  PE L    ++   + VPGV  +H+LHVW L     V +AH+
Sbjct: 212 RILVQAAPEHLQVTAVQDRLIAVPGVTDVHDLHVWTLTSGIEVTSAHL 259


>UniRef50_Q7NRV3 Cluster: Probable cation efflux system; n=1;
           Chromobacterium violaceum|Rep: Probable cation efflux
           system - Chromobacterium violaceum
          Length = 336

 Score = 62.1 bits (144), Expect = 2e-08
 Identities = 68/263 (25%), Positives = 118/263 (44%), Gaps = 23/263 (8%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           ++ S  LL D  H L   + L+  L + +  R      R    R +FG  R EV+G L  
Sbjct: 67  WSGSLALLSDAGHMLTDSLSLLLALWAARIGR------RPATERLSFGHGRAEVLGALLN 120

Query: 95  HVLFASFALALVVNALQ--LGVHSSHGPPPRYPRVI------VGSAVIGLLFNAIN---- 142
            +L    +  +V  A++  L  H+ +G        I      + + V+    +++N    
Sbjct: 121 SLLLFGLSAFIVAEAVERLLRPHAVNGMGVMLIAAIGLAVNVLAARVLSRGAHSLNSRAA 180

Query: 143 YMLLAGSLFVIAAGLTEEWEHEAS--RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTV 200
            + + G LF  AA +        +    ADP LS   A++L+   +  +R A +VL++ V
Sbjct: 181 LLHVLGDLFGSAAAIASGVVIYLTGWMAADPLLSMLVALMLLAAAWRLIRQAVMVLMEGV 240

Query: 201 PEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVF 260
           P  L    +  A   + GV ++H+LHVW +  ++V  +AHV     +D+ +  A  C + 
Sbjct: 241 PPHLDYNRIGEALSAIAGVRSVHDLHVWTMSAERVALSAHVRIAAPQDWPRILA-ACQLM 299

Query: 261 --KRHGIGLVTLQPEFMLTSSRG 281
             +   I  VTLQ E+  ++  G
Sbjct: 300 LSREFCIDHVTLQAEWPASAPAG 322


>UniRef50_Q9PF12 Cluster: Cobalt-zinc-cadmium resistance protein;
           n=26; Proteobacteria|Rep: Cobalt-zinc-cadmium resistance
           protein - Xylella fastidiosa
          Length = 321

 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 70/259 (27%), Positives = 106/259 (40%), Gaps = 32/259 (12%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           T S  LL D  H    +  L+  L++ +  R      R   +R T+G+AR+E  G L   
Sbjct: 60  TRSLALLSDAVHMATDVFALMIALVAVRLSR------RPPDVRRTYGYARLEAFGALVNG 113

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL---AGSLFV 152
           VL       ++  A+Q        P       ++  AV+GL+ N I   LL    G    
Sbjct: 114 VLLFGVGGYILWEAVQ----RLRAPQEIVSSGMLVIAVLGLVINLIVMRLLHAGRGENLS 169

Query: 153 IAAGLTEEWEHEASRIA----------------DPALSACAAIVLVVFNYPFMRSAGLVL 196
           +     E W      +A                DP L+    + ++   +  +  A  VL
Sbjct: 170 MKGAYLEVWSDMLGSVAVIVAAIVIYVTGWYWVDPVLAVLIGLWVLPRTWVLLGEAVNVL 229

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI--YGTHEDYLKNSA 254
           L+ VP+G     +R A    PGV  +H++H+W L     + TAHV+   GT  D L+   
Sbjct: 230 LEGVPKGFELLPIRDALSHHPGVANVHDVHLWALGSRMPLLTAHVVALQGTAPDRLRR-M 288

Query: 255 LVCDVFKRHGIGLVTLQPE 273
           L   + +R  I  VTLQ E
Sbjct: 289 LQELLHERFSIEHVTLQIE 307


>UniRef50_Q4Q622 Cluster: Zinc transporter-like protein; n=3;
           Leishmania|Rep: Zinc transporter-like protein -
           Leishmania major
          Length = 457

 Score = 61.3 bits (142), Expect = 3e-08
 Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 4/122 (3%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           +EH    +ADP  S   A++ +      +     +L+++ P  +    L TA  ++ GV 
Sbjct: 320 YEHSLFNLADPFCSVMFALITLNMTKALLMDLLSILMESTPASVDYYALETALQQIDGVI 379

Query: 221 AIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRH-GIGLVTLQPEFMLTSS 279
           ++H+LHVW L  + V  + H++     + L+ +  +C   K H GIG  T+Q + +   +
Sbjct: 380 SVHDLHVWSLSAEYVSLSVHLVADNSAEALQKAQHIC---KEHFGIGHTTIQIDSVAVGT 436

Query: 280 RG 281
            G
Sbjct: 437 AG 438


>UniRef50_Q6M5R5 Cluster: Co/Zn/Cd efflux system transmembrane
           protein; n=5; Corynebacterium|Rep: Co/Zn/Cd efflux
           system transmembrane protein - Corynebacterium
           glutamicum (Brevibacterium flavum)
          Length = 324

 Score = 60.5 bits (140), Expect = 6e-08
 Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 25/238 (10%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  LL D  H L    GLI   ++    R      R    R T+G+ R EV+  +   
Sbjct: 64  SGSLALLADAMHMLSDSTGLIIAAVAMLIGR------RARTSRATYGYKRAEVLAAMVNA 117

Query: 96  VLFASFALALVVNAL-QLGVHSSHGPPPRYPRVIVGSAVIGL--------------LFNA 140
            +  + ++ +VV A+ +LG              ++G    G+              +  A
Sbjct: 118 TVVTALSVWIVVEAIMRLGKDLEIQTNLMLIVAVIGFVTNGISALVLMRHQDGNINMRGA 177

Query: 141 INYML--LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQ 198
             ++L  + GS+ VI AGL   +       AD   S   A +++   +  ++ A  +LL+
Sbjct: 178 FLHVLSDMLGSVAVIIAGLVIRYTGWMP--ADTIASIAIAAIIIPRAFSLLKEALNILLE 235

Query: 199 TVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV 256
            VP G    ++  A  +VPGV  +H+LH+W +   +++AT H++  +  + L +  ++
Sbjct: 236 RVPTGAEPAEVDAALRKVPGVSDVHDLHIWSIDGKEILATVHLVVDSSTNQLHSCGVL 293


>UniRef50_A7PMH0 Cluster: Chromosome chr14 scaffold_21, whole genome
           shotgun sequence; n=3; core eudicotyledons|Rep:
           Chromosome chr14 scaffold_21, whole genome shotgun
           sequence - Vitis vinifera (Grape)
          Length = 521

 Score = 60.5 bits (140), Expect = 6e-08
 Identities = 35/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)

Query: 162 EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTA---ALRVPG 218
           +++  ++ADPA S   ++++V    P +R++  +LLQ VP  +   DL+ A    +++ G
Sbjct: 403 KYKGWQVADPACSIFISVLIVASVIPLLRNSAEILLQRVPR-VHEHDLKDALKNVMKIRG 461

Query: 219 VFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFM 275
           V  I  LHVW      VV T H+   T  D       V ++    GI  +T+Q E++
Sbjct: 462 VCGIQNLHVWSFTNTDVVGTLHLHISTEADKASTKVQVSNILHDAGIKDLTVQVEYV 518


>UniRef50_Q98H85 Cluster: Cation efflux system protein; n=8;
           Alphaproteobacteria|Rep: Cation efflux system protein -
           Rhizobium loti (Mesorhizobium loti)
          Length = 365

 Score = 59.7 bits (138), Expect = 1e-07
 Identities = 75/279 (26%), Positives = 117/279 (41%), Gaps = 38/279 (13%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           FT S  LL D  H L   + L     +F         GR    + T+G+ R++ +   + 
Sbjct: 87  FTGSLALLADAGHMLADAIALGLAWYAFHL------AGRPATGQLTYGFGRVKTLVAYTN 140

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG----SL 150
            +     AL +V  A Q  +  +  P    P ++V  A++GLL N  ++++L G    SL
Sbjct: 141 GIAIFVIALWIVYEAWQRLL--TPAPVLGGPMLVV--AILGLLVNIGSFLVLHGGDRESL 196

Query: 151 FVIAAGLTEEWEHEASRIA---------------DPALSACAAIVLVVFNYPFMRSAGLV 195
            +  A L    +   S  A               DP LS   +++++   +  MR+A  V
Sbjct: 197 NMRGAILHVLGDLLGSAAAIVAAVVILVTGWTPIDPILSVLVSLLILSTAWSLMRAAAHV 256

Query: 196 LLQTVPEGLG----ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED-YL 250
           LL+ VP  L     A DL T    + GV  +H +HVW +     +AT H       D + 
Sbjct: 257 LLEGVPPSLDRDLIATDLETT---IQGVREVHHMHVWSIDGSSNMATLHACLDEGVDAHR 313

Query: 251 KNSALVCDVFKRHGIGLVTLQPEF-MLTSSRGTEEEKKE 288
             SA+   +   HGI   T++PEF       G  E + E
Sbjct: 314 AVSAIKKRLASEHGISHATVEPEFGQCADEAGDHEHEHE 352


>UniRef50_Q83EH0 Cluster: Cation-efflux family protein; n=3;
           Coxiella burnetii|Rep: Cation-efflux family protein -
           Coxiella burnetii
          Length = 297

 Score = 58.8 bits (136), Expect = 2e-07
 Identities = 55/215 (25%), Positives = 101/215 (46%), Gaps = 23/215 (10%)

Query: 78  RNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSS--HGPPPRYPRV---IVGSA 132
           ++++G+ R EV+   +  +L    ALA++V A++     S  H  P     V   ++   
Sbjct: 75  KHSYGFGRAEVIAAWASSLLMVIIALAVIVEAIKRIQQPSSVHSVPVMLIAVFGILLNVL 134

Query: 133 VIGLLFNA-----INYMLL------AGSLFVIAAGLTEEWEHEASRIADPALSACAAIVL 181
           + GL+  +     I  +LL       G+  V+ +G+   + H A  + DP LS    I++
Sbjct: 135 LAGLISRSEKTLNIRAVLLHVVSDIVGTCAVLLSGIVIFFSHWA--LIDPLLSVLIGILI 192

Query: 182 VVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           ++ +    R +  VL++ VP  L    +    +R  GV A+H++H+W L       +AHV
Sbjct: 193 IISSVRLWRESMTVLMEGVPAHLNIKQVSQTMVRFEGVKAVHDVHIWTLSSGVTALSAHV 252

Query: 242 ---IYGTHEDYLKNSALVCDVFKRHGIGLVTLQPE 273
                 + +D L    L   + +++ I  +TLQPE
Sbjct: 253 NIKNITSWDDVL--LGLKSTLKQQYDIDHITLQPE 285


>UniRef50_A0VV15 Cluster: Cation diffusion facilitator family
           transporter; n=6; Alphaproteobacteria|Rep: Cation
           diffusion facilitator family transporter -
           Dinoroseobacter shibae DFL 12
          Length = 328

 Score = 58.8 bits (136), Expect = 2e-07
 Identities = 66/261 (25%), Positives = 115/261 (44%), Gaps = 34/261 (13%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           +T S  +L D  H+L  + G++  + + +  R    + R      +FGW R E++G L  
Sbjct: 37  WTGSIAVLSDAFHTLSAVGGVLVAITAQRIARRPADSTR------SFGWYRAEIIGALVN 90

Query: 95  HVLFASFALALV-VNALQLG--VHSSHGPP--PRYPRVIVGSAVIGLLFNAINYMLLA-- 147
                  AL ++ + A++LG  +H + GP     +  ++     + L++ +    L A  
Sbjct: 91  GGFLLGMALLVIWMGAMRLGDPIHLATGPMLWVAFGGLVTEVVSLALMWQSSKDDLNARG 150

Query: 148 ----------GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLL 197
                     GSL +I   L  E+    +   DP L     +VL+  +   ++ A  +L+
Sbjct: 151 ALWHIIQTFVGSLLIIVTALVIEFTGFLA--IDPILGMAFGVVLLWASVGVIKEAVHILM 208

Query: 198 QTVPEGLGACDLRTAALR-VPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV 256
           +  PEG    D  TA L    GV  +H +H W L   K   +AH+    H+   + + L+
Sbjct: 209 EGTPEGTDL-DAVTADLNGQDGVLDVHHVHAWTLTSGKHAFSAHI---RHQSPAEAADLL 264

Query: 257 CDVFKR----HGIGLVTLQPE 273
              ++R    HG  +VTLQ E
Sbjct: 265 NRAYRRLTEQHGFHMVTLQLE 285


>UniRef50_O45923 Cluster: Putative uncharacterized protein ttm-1;
           n=3; Caenorhabditis|Rep: Putative uncharacterized
           protein ttm-1 - Caenorhabditis elegans
          Length = 410

 Score = 58.8 bits (136), Expect = 2e-07
 Identities = 41/163 (25%), Positives = 76/163 (46%), Gaps = 11/163 (6%)

Query: 113 GVHSSHGPPPRYPRVIVGSAVIGLLFNAINYM-LLAGSLFVIAAGLTEEWEHEASRIADP 171
           G HSSHG       V V +A+I ++ + +  + +L  +L +   G T         +ADP
Sbjct: 239 GGHSSHGHAHDGKNVNVRAALIHVIGDLVQSIGVLIAALIIRFTGWT---------LADP 289

Query: 172 ALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLH 231
             +   +I+++      MR    VL++  P      D++ A   + GV  +H+LH+W + 
Sbjct: 290 ICTFLFSIIVLFTTVTVMRDIFFVLMEATPSHYDLSDVKKALSALEGVKGVHDLHLWSIG 349

Query: 232 RDKVVATAHVIYGTHEDYLKNSALVCDVFKRH-GIGLVTLQPE 273
            DK   + H+   +    ++N A    + +R  G+ + T+Q E
Sbjct: 350 MDKTAFSVHLALESPNRAMENVAEARSLIRRRFGVAVATVQVE 392



 Score = 36.7 bits (81), Expect = 0.80
 Identities = 29/112 (25%), Positives = 54/112 (48%), Gaps = 9/112 (8%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           +  S  ++ D  H L  L+  I ++ + +  R           R +FG+ R EV+G L+ 
Sbjct: 125 WAQSLAIMTDAGHMLSDLLSFIISIFAIRCARLPASK------RLSFGYERAEVLGALTS 178

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL 146
            ++       LVV A+Q  V++ H        V++ +A +G+LFN +  ++L
Sbjct: 179 VIILWVLTTVLVVVAIQRIVNNEHEVD---ADVMLITAGVGVLFNIVMGLVL 227


>UniRef50_Q1AYG3 Cluster: Cation diffusion facilitator family
           transporter; n=1; Rubrobacter xylanophilus DSM 9941|Rep:
           Cation diffusion facilitator family transporter -
           Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
          Length = 314

 Score = 58.0 bits (134), Expect = 3e-07
 Identities = 39/138 (28%), Positives = 68/138 (49%), Gaps = 5/138 (3%)

Query: 137 LFNAINYML--LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGL 194
           L  A+ ++L  L GSL V+ +G+           ADP +SA   ++++  ++  +R +  
Sbjct: 151 LQGALRHVLADLLGSLGVLVSGMVVLLTGWYP--ADPLVSAAIGLLILASSWRLLRDSVN 208

Query: 195 VLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED-YLKNS 253
           +LL+  P G+ A ++        GV  +H+LHVW +       +AHV+    ED + K  
Sbjct: 209 ILLEAAPHGMDAAEIGRRMASTSGVAEVHDLHVWTITSGFPALSAHVLVAAGEDCHAKRR 268

Query: 254 ALVCDVFKRHGIGLVTLQ 271
            L   + + +GI   TLQ
Sbjct: 269 ELEQLLREEYGISHTTLQ 286


>UniRef50_A1UA75 Cluster: Cation diffusion facilitator family
           transporter; n=10; Corynebacterineae|Rep: Cation
           diffusion facilitator family transporter - Mycobacterium
           sp. (strain KMS)
          Length = 298

 Score = 58.0 bits (134), Expect = 3e-07
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 40/230 (17%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  LL D  H L  LV +   L +    R   G+    R   T+GW R EV   ++  V
Sbjct: 40  DSIALLADAGHMLTDLVAMFMGLTAVLLAR--RGSASPAR---TYGWHRAEVFTAVANAV 94

Query: 97  LFASFALALVVNALQLGVHSSHGPP-PRYPRVIVGSAVIGLLFNAINYMLL--------- 146
           L  + A+ ++  A++        P  P  P ++V  A+ GL  NA+  +LL         
Sbjct: 95  LLLAMAVFILYEAVE---RLGDAPDVPGVPMIVV--ALAGLAANAVVVLLLRSHSKESLA 149

Query: 147 ------------AGSLFVIAAGL---TEEWEHEASRIADPALSACAAIVLVVFNYPFMRS 191
                        GS+ V+ AG+   T  W +     AD  ++   A+ ++       R+
Sbjct: 150 VKGAYMEVVADTVGSIGVLIAGIVTVTTSWPY-----ADVVVAVFVALWVLPRAISLARA 204

Query: 192 AGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           A  +L ++ P  +   +L+TA   V GV  +H+LHVW L   K V TAH+
Sbjct: 205 ALRILSESSPAHIDVDELKTALCAVEGVTEVHDLHVWTLVPGKDVVTAHL 254


>UniRef50_Q57YU8 Cluster: Metal-ion transporter, putative; n=4;
           Trypanosoma|Rep: Metal-ion transporter, putative -
           Trypanosoma brucei
          Length = 471

 Score = 58.0 bits (134), Expect = 3e-07
 Identities = 34/131 (25%), Positives = 62/131 (47%), Gaps = 6/131 (4%)

Query: 144 MLLAGSLFVIAAGLT---EEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTV 200
           ++LAG    +A   +     + +    +ADP  S   A++ +    P +R    +L+++ 
Sbjct: 322 VILAGIFIYVANRYSYGVPSYRYSIYNLADPLCSLLFAVITLNMTRPLLRDLLGILMEST 381

Query: 201 PEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVF 260
           P G+   +L +A   + GV  +H+LHVW +  D    + H+     +  L+ +  VC   
Sbjct: 382 PPGINYSELLSALRSIKGVEGVHDLHVWSIASDYAALSVHLEADDKDAALQEAQEVC--- 438

Query: 261 KRHGIGLVTLQ 271
           KR GI   T+Q
Sbjct: 439 KRFGITHTTIQ 449


>UniRef50_UPI0000F1F0D2 Cluster: PREDICTED: hypothetical protein;
           n=1; Danio rerio|Rep: PREDICTED: hypothetical protein -
           Danio rerio
          Length = 320

 Score = 57.2 bits (132), Expect = 5e-07
 Identities = 38/131 (29%), Positives = 67/131 (51%), Gaps = 6/131 (4%)

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           L  S+ V+ + L   ++ E  +IADP  +   ++ ++   +  MR   +VL++  P G+ 
Sbjct: 176 LLQSISVLVSALIIFFKPEY-KIADPICTFLFSLFVLGTTFTIMRDIVIVLMEGTPAGVN 234

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYG---THEDYLKNSALVCDVFKR 262
             ++R   L V GV A+H LH+W L  ++ V +AHV        ++ L+    VC  F +
Sbjct: 235 YNEVRQLLLGVKGVKAVHNLHIWALTMNQAVLSAHVATDETVDPQEVLREMTQVC--FTK 292

Query: 263 HGIGLVTLQPE 273
           +    VT+Q E
Sbjct: 293 YSFHSVTIQLE 303


>UniRef50_Q4T2T2 Cluster: Chromosome undetermined SCAF10190, whole
           genome shotgun sequence; n=2; Tetraodontidae|Rep:
           Chromosome undetermined SCAF10190, whole genome shotgun
           sequence - Tetraodon nigroviridis (Green puffer)
          Length = 317

 Score = 57.2 bits (132), Expect = 5e-07
 Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           +IADP  +   +I ++      +R   +VL++  P G+   D+R   L V GV A+H LH
Sbjct: 194 KIADPICTFLFSIFVLFTTVTIIRDIVIVLMEGAPVGVKYSDVRDGLLAVKGVRAVHNLH 253

Query: 227 VWQLHRDKVVATAHVIYGTHED---YLKNSALVCDVFKRHGIGLVTLQPE 273
           +W L  ++ V TAHV      D    L+     C  F  +    VT+Q E
Sbjct: 254 IWALTMNQAVLTAHVAIDETVDAQSVLREMTQAC--FSSYNFHSVTIQME 301


>UniRef50_Q1R0K1 Cluster: Cation diffusion facilitator family
           transporter; n=2; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Chromohalobacter
           salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB13768)
          Length = 327

 Score = 56.4 bits (130), Expect = 9e-07
 Identities = 58/218 (26%), Positives = 95/218 (43%), Gaps = 28/218 (12%)

Query: 78  RNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLL 137
           R TFG+ R +V+      +     A+ +++ A+Q        P       ++  AV+GLL
Sbjct: 98  RRTFGYQRFQVLAAFINGLTLLGIAVWILIAAVQRFFQ----PVEVMAAPMLAIAVLGLL 153

Query: 138 FNAINYMLLAGS-----------LFVIAAGLTEEWEHEASRIA--------DPALSACAA 178
            N + + +L G            L V+   L       AS +         DP LS  AA
Sbjct: 154 VNVVVFRILHGGDHENLNLRGALLHVMGDLLGSVAAIVASLVIMATGWMPIDPLLSMLAA 213

Query: 179 IVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVAT 238
            +++   +  +R +G  LL+  PEG+    +R A   + GV ++H+LHVW L     + +
Sbjct: 214 ALILRGAWKIVRRSGHTLLEGTPEGIDVDGIRAALEDIEGVVSVHDLHVWGLTPQDPLLS 273

Query: 239 AHVIYG---THEDYLKNSALVCDVFKRHGIGLVTLQPE 273
            H++     +H   LK  A    + +R GI   TLQ E
Sbjct: 274 LHLVVRDDMSHAVMLK--AAYARLHERFGISHATLQVE 309


>UniRef50_Q1GPY2 Cluster: Cation diffusion facilitator family
           transporter; n=7; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Sphingopyxis alaskensis
           (Sphingomonas alaskensis)
          Length = 312

 Score = 56.4 bits (130), Expect = 9e-07
 Identities = 56/227 (24%), Positives = 96/227 (42%), Gaps = 33/227 (14%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           NS  LL D  H L  +  LI  L++ +         R    + TFG+ R E++      +
Sbjct: 54  NSLALLSDAGHMLTDVAALIIALMAIRIG------ARPADDQRTFGYRRFEILAAAFNAL 107

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA--------- 147
           +  + A+ ++V AL    +    P P     ++  AV GL  N I+  LL+         
Sbjct: 108 MLFAVAIYVLVEAL----NRFRDPEPVQSTGMLVVAVAGLAINLISMRLLSSGKEQSLNL 163

Query: 148 ------------GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLV 195
                       GS+ VIA  +   +    +   DP ++    + ++   +  +R    V
Sbjct: 164 KGAYLEVWADMLGSIGVIAGAIAIRFT--GATWIDPVVAVGIGLWVLPRTWILLRDTANV 221

Query: 196 LLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
           LL+ VP G+   ++R A   V GV + H+LHVW +    V  + H++
Sbjct: 222 LLEGVPRGMSLDEVRRAISEVSGVQSAHDLHVWSITTGNVSCSVHIV 268


>UniRef50_A7I6Y5 Cluster: Cation diffusion facilitator family
           transporter; n=1; Candidatus Methanoregula boonei
           6A8|Rep: Cation diffusion facilitator family transporter
           - Methanoregula boonei (strain 6A8)
          Length = 317

 Score = 56.0 bits (129), Expect = 1e-06
 Identities = 45/179 (25%), Positives = 81/179 (45%), Gaps = 21/179 (11%)

Query: 80  TFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN 139
           TFG+ R+E+   +   +L    +  +++ AL      SH P P    +++  A++GL+ N
Sbjct: 84  TFGYHRLEIAAAVINGLLLIGVSALIILEAL---ARFSH-PSPVNSTLMLAVALVGLVAN 139

Query: 140 AINYMLLAGS----------------LFVIAAGLTEEW-EHEASRIADPALSACAAIVLV 182
           AI+  +L GS                L  +A  +   W       + DP L    +++++
Sbjct: 140 AISAFVLHGSHDLNTRSAFLHVIGDLLSSLAVIVAALWIALTGQTVVDPLLGLAISVLIL 199

Query: 183 VFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
             ++  +  +  +LLQ  P  +   D+  A   VPGV  +H +H+W L  +  V  AHV
Sbjct: 200 FSSFSILAESFRILLQFAPRDVPIEDVIAAMESVPGVSGVHNVHLWTLCSNINVLDAHV 258


>UniRef50_A7B9C7 Cluster: Putative uncharacterized protein; n=1;
           Actinomyces odontolyticus ATCC 17982|Rep: Putative
           uncharacterized protein - Actinomyces odontolyticus ATCC
           17982
          Length = 343

 Score = 55.6 bits (128), Expect = 2e-06
 Identities = 63/238 (26%), Positives = 96/238 (40%), Gaps = 39/238 (16%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           ++ S +L  D  H +    GL+  LI+ +  R      R    ++T+GWAR EV+     
Sbjct: 80  WSGSLSLAADAGHMVVDASGLVIALIAARLMR------RPRDEKHTWGWARSEVLAA--- 130

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPP--RYPRVIVGSAVIGLLFNAINYMLLAGS--- 149
             L A   L +       G      PP     P ++VG  +IGL  N ++  +LAG    
Sbjct: 131 -TLQAGMLLIICAIVAWEGAWRLLSPPEVEAGPMLLVG--IIGLASNVVSLAILAGGRDA 187

Query: 150 -------------------LFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMR 190
                                ++AAG   EW    +R AD   S   A ++       +R
Sbjct: 188 NLNMKAAFLEVANDALGSVAVIVAAGA--EWAFGWTR-ADAIASLLIAALMAPRALTLLR 244

Query: 191 SAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED 248
            +  +L++  P  +   +LR   L V GV  +H+LHV  +    V  TAHV    H D
Sbjct: 245 RSVAILMEQAPANVDVTELRAHMLDVDGVLDVHDLHVAAVSSHLVTVTAHVTVSEHAD 302


>UniRef50_A0NU32 Cluster: Cation efflux system protein; n=1; Stappia
           aggregata IAM 12614|Rep: Cation efflux system protein -
           Stappia aggregata IAM 12614
          Length = 323

 Score = 55.6 bits (128), Expect = 2e-06
 Identities = 33/104 (31%), Positives = 52/104 (50%), Gaps = 2/104 (1%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALR-VPGVFAIHELHVW 228
           DP LS   A+++V      MR +  +LL+  P  +    L+T  L  VPG+  ++ +H+W
Sbjct: 215 DPILSVFVALLIVRSAVSVMRQSAHILLEGAPADIDRDTLKTDLLNAVPGLVDVYHIHLW 274

Query: 229 QLHRDKVVATAHVIYGTHEDYLKNSALVCDVFK-RHGIGLVTLQ 271
            L   K+ AT H      +D       + +  K RHGIG VT++
Sbjct: 275 SLAEGKINATMHATLKPEDDAENVLRQIRERLKSRHGIGHVTIE 318


>UniRef50_Q8IWU4 Cluster: Zinc transporter 8; n=18; Tetrapoda|Rep:
           Zinc transporter 8 - Homo sapiens (Human)
          Length = 369

 Score = 54.8 bits (126), Expect = 3e-06
 Identities = 23/82 (28%), Positives = 45/82 (54%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           +IADP  +   +I+++      ++   ++L++ VP+ L    ++   L V GV ++H LH
Sbjct: 245 KIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLH 304

Query: 227 VWQLHRDKVVATAHVIYGTHED 248
           +W L  ++V+ +AHV      D
Sbjct: 305 IWSLTMNQVILSAHVATAASRD 326


>UniRef50_UPI00006CBB53 Cluster: cation diffusion facilitator family
           transporter containing protein; n=1; Tetrahymena
           thermophila SB210|Rep: cation diffusion facilitator
           family transporter containing protein - Tetrahymena
           thermophila SB210
          Length = 525

 Score = 54.4 bits (125), Expect = 4e-06
 Identities = 36/142 (25%), Positives = 71/142 (50%), Gaps = 8/142 (5%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSA 192
           VIG +  +I  ++ A  ++  A   T+E+++    +ADP  +   +I+++      ++  
Sbjct: 372 VIGDIIQSIGVVVAALLIYFYAN--TDEYDYW--HLADPICTYLFSILVLFTTVKIVKDC 427

Query: 193 GLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV-IYGTHEDYLK 251
             VL++  P+ +   D +   L +  V  IH+LH+W L   K   + H+ + G  E  L+
Sbjct: 428 ITVLMEGTPQDIEIKDFKDQLLAIDKVVQIHDLHIWSLSIGKPSMSVHIFVNGDKEQVLR 487

Query: 252 NSALVCDVFKRHGIGLVTLQPE 273
            +  +C   ++HGI   T+Q E
Sbjct: 488 EATKIC---RQHGIYHSTIQIE 506


>UniRef50_Q9ABC7 Cluster: Cation efflux family protein; n=35;
           Bacteria|Rep: Cation efflux family protein - Caulobacter
           crescentus (Caulobacter vibrioides)
          Length = 361

 Score = 54.4 bits (125), Expect = 4e-06
 Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 5/107 (4%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +S     V+V+  +  +R +  + L   P G+    +R      PGV  +H+LH+W 
Sbjct: 241 DPVVSLVIVAVIVLGTWGLLRDSLDLALDATPRGIDTQKVRDWLAARPGVSEVHDLHIWA 300

Query: 230 LHRDKVVATAHVIY---GTHEDYLKNSALVCDVFKRHGIGLVTLQPE 273
           +   +   TAHV+      H+ +L ++    ++  R  IG VT+Q E
Sbjct: 301 MSTTETALTAHVVRQLDADHDQFLHDAC--AELASRFNIGHVTIQVE 345


>UniRef50_Q3SKU3 Cluster: Cation efflux protein; n=4;
           Proteobacteria|Rep: Cation efflux protein - Thiobacillus
           denitrificans (strain ATCC 25259)
          Length = 313

 Score = 54.4 bits (125), Expect = 4e-06
 Identities = 43/130 (33%), Positives = 62/130 (47%), Gaps = 9/130 (6%)

Query: 148 GSLFVIAAGL---TEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGL 204
           GS+  IAAG+   T  W        DP LS   A++++V     +R    VL++ VP  +
Sbjct: 168 GSVAAIAAGIVVVTTGWTP-----IDPLLSILVAVLILVSALRLLREVVHVLMEGVPLDV 222

Query: 205 GACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLK-NSALVCDVFKRH 263
               +      + GV  +H+LHVW L    V  +AH+      D+    +A   D+  RH
Sbjct: 223 ELEAVGRDLAALDGVLRVHDLHVWTLSTGTVALSAHLELRDLADWPGILAAARRDMDARH 282

Query: 264 GIGLVTLQPE 273
           GI  VTLQPE
Sbjct: 283 GIRHVTLQPE 292


>UniRef50_Q4Y0W9 Cluster: Zinc transporter, putative; n=3;
           Plasmodium (Vinckeia)|Rep: Zinc transporter, putative -
           Plasmodium chabaudi
          Length = 530

 Score = 54.4 bits (125), Expect = 4e-06
 Identities = 30/118 (25%), Positives = 55/118 (46%), Gaps = 8/118 (6%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           W +    I DP  S     ++       ++    VL++  P  +   D++   L++PGV 
Sbjct: 393 WYNPKYSITDPICSIIFCFIVFSTTLSVIKEILNVLMEGTPVSINLIDIKNDILKIPGVI 452

Query: 221 AIHELHVWQLHRDKVVATAHVIYGTHEDY----LKNSALVCDVFKRHGIGLVTLQPEF 274
            +H+LHVW L   K     H++   H+ Y    L N+ ++C   K++ I   T+Q ++
Sbjct: 453 DVHDLHVWSLSIGKPALACHIV--AHKQYSHTVLHNATVLCQ--KKYKILHTTVQTDY 506


>UniRef50_Q4SCU9 Cluster: Chromosome 14 SCAF14647, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 14 SCAF14647, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 448

 Score = 54.0 bits (124), Expect = 5e-06
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 8/116 (6%)

Query: 33  SHFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRL 92
           S  T+S ++L D+ H L  ++ LI  L++ ++      T +     NTFGW R EV+G L
Sbjct: 23  SRITSSLSMLSDSFHMLSDVIALIVALVAVRFAEKTHSTSK-----NTFGWIRAEVMGAL 77

Query: 93  SVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG 148
              V   +    +V+ A++     +       P V+ G    GLL N +   L  G
Sbjct: 78  VNAVFLTALCFTIVLEAIE---RFTEPHEIESPEVVAGVGAAGLLVNLLGLCLFHG 130


>UniRef50_Q2J9T2 Cluster: Cation diffusion facilitator family
           transporter; n=3; Frankia|Rep: Cation diffusion
           facilitator family transporter - Frankia sp. (strain
           CcI3)
          Length = 405

 Score = 53.2 bits (122), Expect = 9e-06
 Identities = 46/140 (32%), Positives = 61/140 (43%), Gaps = 14/140 (10%)

Query: 147 AGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           A SL V AAG    W        DP +S   A+++ V     + SA  VLL+  P  L  
Sbjct: 197 AVSLAVAAAG-GAIWLVGGWYWLDPLVSLVIALLIAVQGARLLASASRVLLEATPASLDV 255

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYG----THED----YLKNSALVCD 258
             +R   LR P V  +H+LHVW L    + A+ H+  G     H D     L  +  V D
Sbjct: 256 AAVRADILRDPHVLDVHDLHVWSLSDRLLAASVHLELGHLDSAHGDGGHPSLAQARSVSD 315

Query: 259 VFK-----RHGIGLVTLQPE 273
             K     RHGI   T++ E
Sbjct: 316 AIKAMLAARHGITHATIEAE 335


>UniRef50_P13512 Cluster: Cobalt-zinc-cadmium resistance protein
           czcD; n=5; Bacteria|Rep: Cobalt-zinc-cadmium resistance
           protein czcD - Ralstonia metallidurans (strain CH34 /
           ATCC 43123 / DSM 2839)
          Length = 316

 Score = 53.2 bits (122), Expect = 9e-06
 Identities = 54/229 (23%), Positives = 92/229 (40%), Gaps = 29/229 (12%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           T S  L+ D  H L   V L   L +    +      R    + TFG+ R E++      
Sbjct: 38  TKSLALISDAAHMLTDTVALAIALAAIAIAK------RPADKKRTFGYYRFEILAAAFNA 91

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG---SLFV 152
           +L    A+ ++  A  L + S   PP      +   AV+GL+ N I+  +L+    S   
Sbjct: 92  LLLFGVAIYILYEAY-LRLKS---PPQIESTGMFVVAVLGLIINLISMRMLSSGQSSSLN 147

Query: 153 IAAGLTEEWEHEASRIA----------------DPALSACAAIVLVVFNYPFMRSAGLVL 196
           +     E W      +                 D A++    + ++   +  ++S+  VL
Sbjct: 148 VKGAYLEVWSDLLGSVGVIAGAIIIRFTGWAWVDSAIAVLIGLWVLPRTWILLKSSLNVL 207

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGT 245
           L+ VP+ +   ++    L  PGV + H+LH+W L   K   T HV+  T
Sbjct: 208 LEGVPDDVDLAEVEKQILATPGVKSFHDLHIWALTSGKASLTVHVVNDT 256


>UniRef50_Q0EWA1 Cluster: Cation efflux transporter; n=1;
           Mariprofundus ferrooxydans PV-1|Rep: Cation efflux
           transporter - Mariprofundus ferrooxydans PV-1
          Length = 301

 Score = 52.8 bits (121), Expect = 1e-05
 Identities = 52/200 (26%), Positives = 88/200 (44%), Gaps = 24/200 (12%)

Query: 82  GWARIEVVGRLS----VH--VLFASFALALVVNALQLG-VHSSHGPPPRYPRV-IVGSAV 133
           GW   E  GRLS    VH  ++ A  A+ L+VN + L  +H  H    R     +VG A+
Sbjct: 102 GWITWEATGRLSAPPAVHGGMVIAIGAIGLIVNLVILTWLHGEHDINSRAAFWHVVGDAL 161

Query: 134 IGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                         GS+  + AG+   +        DP LS   A +L    +  +R   
Sbjct: 162 --------------GSVAAVIAGVVIYFTGWMP--IDPILSFLVAAILAWGGWRLIRETT 205

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNS 253
             L++ VP+ +    +      V G+  IH +H+W+L   ++  +AHV   +  ++ +  
Sbjct: 206 AELMEAVPDAIDTEVVEACLKAVQGISDIHHIHLWKLPDGRMGMSAHVEIESMSEWDEIL 265

Query: 254 ALVCDVFKRHGIGLVTLQPE 273
            L+ +  ++ G+   TLQPE
Sbjct: 266 PLLLEKLRKQGVDHATLQPE 285


>UniRef50_A5ESK1 Cluster: Cation efflux system protein czcD; n=4;
           Bradyrhizobiaceae|Rep: Cation efflux system protein czcD
           - Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
          Length = 305

 Score = 52.8 bits (121), Expect = 1e-05
 Identities = 35/110 (31%), Positives = 54/110 (49%), Gaps = 4/110 (3%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSA 192
           V G  F  ++ ML  GSL VIAA L   +      +ADP + A   + +V   +  +  A
Sbjct: 155 VQGAYFEVLSDML--GSLGVIAAALIIMFT--GWTLADPIIGAGIGLFIVPRTWKLLNQA 210

Query: 193 GLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
             +L++ VP  +    L  A   +PGV A+H+LHVW +       T H++
Sbjct: 211 VHILMEGVPAEIDLPLLEKALREIPGVTAVHDLHVWTITSGTDSLTGHLV 260


>UniRef50_Q5NP70 Cluster: Cation efflux system protein; n=2;
           Zymomonas mobilis|Rep: Cation efflux system protein -
           Zymomonas mobilis
          Length = 322

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 28/105 (26%), Positives = 52/105 (49%), Gaps = 1/105 (0%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP+LS    +VL+  ++  ++ +  + L  VP  +    + T   ++P V  +H +H+W 
Sbjct: 208 DPSLSLAIVVVLLWSSWSLIKRSFAMALNAVPPSIDVSAVVTRLDQLPDVINVHHVHIWP 267

Query: 230 LHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRH-GIGLVTLQPE 273
           +   +   TAH++    ++       V D+ K+   IG VTLQ E
Sbjct: 268 VSTSETAMTAHIVRSKIQNNDAFIGSVADIMKKEFDIGHVTLQIE 312


>UniRef50_Q0AGJ2 Cluster: Cation diffusion facilitator family
           transporter; n=1; Nitrosomonas eutropha C91|Rep: Cation
           diffusion facilitator family transporter - Nitrosomonas
           eutropha (strain C71)
          Length = 318

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 61/256 (23%), Positives = 105/256 (41%), Gaps = 30/256 (11%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  L+ D+ H +     L+  L++++  R    + R      T+G+ R+ V+  L+  
Sbjct: 61  SGSLALIADSGHMISDAAALLLALVAYRIARKPADSTR------TYGFHRVRVLAALANG 114

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL--------- 146
           V      L LVV  +   +   H P       ++  AVIGL+ N +   +L         
Sbjct: 115 VTL----LLLVVWIILEAIGRMHTPTEILAGPMLIVAVIGLVINLVGAWVLWSGNKEDGN 170

Query: 147 -AGSLFVIAAGLTEEWEHEASRIA---------DPALSACAAIVLVVFNYPFMRSAGLVL 196
             G+L  I   L       A+ +          DP LS   A++++   +  ++ +  VL
Sbjct: 171 LRGALLHIIGDLLGSVGAVAAAVGIMFTGWTILDPILSVLVALLIIRSAWVLVKDSVHVL 230

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV 256
           LQ VP G+    +     ++P +      H W L  +  +AT HV      D L    LV
Sbjct: 231 LQVVPRGMDTRVVENGLTQLPEIEEAGHFHAWILADETTIATVHVSPARGVDPLSLPPLV 290

Query: 257 CD-VFKRHGIGLVTLQ 271
              + +R+ I  VT+Q
Sbjct: 291 SSWLRERYAIDHVTVQ 306


>UniRef50_Q8IBU1 Cluster: Zinc transporter, putative; n=2;
           Plasmodium falciparum|Rep: Zinc transporter, putative -
           Plasmodium falciparum (isolate 3D7)
          Length = 556

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 34/131 (25%), Positives = 60/131 (45%), Gaps = 6/131 (4%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           W      IADP  S     ++       ++    +L++  P  +   DL+   L++PGV 
Sbjct: 421 WYDPKYSIADPICSIIFCCIVFSTTISVIKEILNILMEGTPVSINLIDLKNDLLKIPGVL 480

Query: 221 AIHELHVWQLHRDKVVATAHVIYG-THEDYLKNSA-LVCDVFKRHGIGLVTLQPEFMLTS 278
            +H+LHVW L   K     H++   T+   + N A L+C    ++ I   T+Q ++  +S
Sbjct: 481 DVHDLHVWSLSIGKPALACHIVASKTYSHSVLNDATLLCQ--NKYKILHTTVQTDY--SS 536

Query: 279 SRGTEEEKKEL 289
           +R   E +  L
Sbjct: 537 NRSNCETEAHL 547


>UniRef50_Q22GX2 Cluster: Cation diffusion facilitator family
           transporter containing protein; n=1; Tetrahymena
           thermophila SB210|Rep: Cation diffusion facilitator
           family transporter containing protein - Tetrahymena
           thermophila SB210
          Length = 352

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 40/145 (27%), Positives = 68/145 (46%), Gaps = 10/145 (6%)

Query: 145 LLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGL 204
           ++ G+LFV   G       E   IADP ++    IV+     P M+ +  VL++  P+ +
Sbjct: 217 VIIGALFVFFGG-------EDYFIADPIITIVFTIVVTFTTLPVMKDSIKVLMEGQPDDI 269

Query: 205 GACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHG 264
               ++    +V GV  +H+LHVW ++   V  TAH+   T    L  +  +C   K+ G
Sbjct: 270 KYETVKEKLEKVSGVVNVHDLHVWSINPGFVSLTAHICSKTPSVTLFEATKLC---KKLG 326

Query: 265 IGLVTLQPEFMLTSSRGTEEEKKEL 289
           I   T+Q E      +   ++ +EL
Sbjct: 327 IVHSTIQVENFFEQDKYDYKKCEEL 351



 Score = 34.7 bits (76), Expect = 3.2
 Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 16/132 (12%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVG-RL 92
           + +NS  ++ D  H L  +VG + T+++    R       +     T+G+ R E++G  +
Sbjct: 65  YLSNSLAIMTDAVHLLSDVVGFLVTILAIYISRL------KANSTMTYGYHRAEIIGAMI 118

Query: 93  SVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFV 152
           S+ +++   A   V      G+     PP      ++  A  GL FN +   +L   L  
Sbjct: 119 SILIIWVLIAWMFVE-----GIERFFKPPEIQGTTMLILACCGLFFNLVLMKILETKLET 173

Query: 153 IAAGLTEEWEHE 164
           +    TEE + E
Sbjct: 174 V----TEESQKE 181


>UniRef50_A5JZM5 Cluster: Cation diffusion facilitator transporter
           domain containing protein; n=2; Plasmodium|Rep: Cation
           diffusion facilitator transporter domain containing
           protein - Plasmodium vivax
          Length = 592

 Score = 52.4 bits (120), Expect = 2e-05
 Identities = 26/101 (25%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           W +    I DP  S     ++       ++    VL++  P  +   D++   L++PGV 
Sbjct: 455 WYNPKYSITDPICSIIFCFIVFSTTISVIKEILNVLMEGTPVSINLIDIKNDLLKIPGVI 514

Query: 221 AIHELHVWQLHRDKVVATAHVIYGTHEDY----LKNSALVC 257
            +H+LHVW L   K     H++   H+++    L N+ L+C
Sbjct: 515 DVHDLHVWSLSIGKPALACHIV--AHKNFAHTALNNATLLC 553


>UniRef50_Q8KBG3 Cluster: Cation efflux family protein; n=5;
           Chlorobiaceae|Rep: Cation efflux family protein -
           Chlorobium tepidum
          Length = 307

 Score = 52.0 bits (119), Expect = 2e-05
 Identities = 54/224 (24%), Positives = 99/224 (44%), Gaps = 24/224 (10%)

Query: 71  TGREGRLRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVG 130
           +GR G  R ++G+ R  + G L   ++  + +  ++V A+   +H  H   P   + +V 
Sbjct: 75  SGRTGDKRYSYGYQRFSIFGALVSALMMLASSFLVLVEAVPRLLHPEH---PN-AKGMVA 130

Query: 131 SAVIGLLFNAINYMLLAG----SLFVIAAGLTEE---WEH----------EASRIADPAL 173
            A++G+  NA+  + L G    +  VIA  L E+   W             +  I DP L
Sbjct: 131 FALVGVAVNALAMLRLKGQAGMNARVIALHLLEDVLGWLSVLLVSVVLLFTSLPILDPLL 190

Query: 174 SACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRD 233
           +    + ++      +R+   V LQ VP  L    +     +   V  +H  H+W L   
Sbjct: 191 AIVITLYILTGVVKNLRAMVPVFLQAVPSELSLDKVVADIQQTEHVTGVHHAHLWSLDGQ 250

Query: 234 KVVATAHVIYGTHEDYLKNSALVCDVFK---RHGIGLVTLQPEF 274
           + V TAH+  G   +  + +++  ++ K   RHGI   T++ E+
Sbjct: 251 RTVFTAHLEIGCDVNPAEYASIKEEIRKLVARHGIYHSTVELEY 294


>UniRef50_Q03ZB0 Cluster: Co/Zn/Cd efflux system component; n=1;
           Leuconostoc mesenteroides subsp. mesenteroides ATCC
           8293|Rep: Co/Zn/Cd efflux system component - Leuconostoc
           mesenteroides subsp. mesenteroides (strain ATCC 8293
           /NCDO 523)
          Length = 305

 Score = 52.0 bits (119), Expect = 2e-05
 Identities = 52/195 (26%), Positives = 89/195 (45%), Gaps = 16/195 (8%)

Query: 80  TFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN 139
           T GW  + VV  + + +   +FA A++  A   GV   HG       +   +A I LL +
Sbjct: 115 TTGWL-VMVVAAVGIVI---NFATAMLFKAS--GVPDEHGHHHEQD-LNAKTAYIHLLAD 167

Query: 140 AINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQT 199
           A        S+ VI AGL  +       + DP +S    +++ V ++P M+S   + L  
Sbjct: 168 A------GVSVGVIIAGLLIQVT--GWHVIDPIVSMIIGVIIAVTSWPVMKSTFNLALNG 219

Query: 200 VPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSA-LVCD 258
           VP+ +   D+        GV  +H+LH+W L   +   T H+    + D  +  A +  D
Sbjct: 220 VPDNVNESDVLRYLSTHEGVEQLHDLHIWPLSTTEAAMTVHLSVKKNVDEQELLANISSD 279

Query: 259 VFKRHGIGLVTLQPE 273
           + +++ I  VT+Q E
Sbjct: 280 LREKYDISHVTIQIE 294


>UniRef50_A6Q136 Cluster: Cation efflux system protein, CDF family;
           n=2; unclassified Epsilonproteobacteria|Rep: Cation
           efflux system protein, CDF family - Nitratiruptor sp.
           (strain SB155-2)
          Length = 301

 Score = 52.0 bits (119), Expect = 2e-05
 Identities = 56/265 (21%), Positives = 107/265 (40%), Gaps = 37/265 (13%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           + NS +LL D  H+L  ++ L+          A+    +      TFG  R E++  L  
Sbjct: 33  YANSLSLLSDAMHNLSDVLSLVIAWA------ANTIAAKPSTKSYTFGLKRAEIIAALFN 86

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG------ 148
             L    A+ LV+ A     H    P       ++    + +L N ++ +L+        
Sbjct: 87  ASLLLGIAIFLVIEAF----HKFFHPQSVDSLWVIWLGGLSILLNTLSVLLVKKDSEKNI 142

Query: 149 ---------------SLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                          S+ V+  GL  ++ H      DPA+S   A  L+  +   ++ + 
Sbjct: 143 NIKAAYLHLLTDVFTSIAVVVGGLLMQFYH--IYWVDPAVSLLIAFYLIYASIDIVKESI 200

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNS 253
            +L++  P+ +    +     ++  V  IH +H+W+L    +   AH+ +  +    + +
Sbjct: 201 AILMEFAPKSIDIEKIADEVKKIEKVENIHHIHIWRLGEHDIFLEAHIDFKENLPLQEVT 260

Query: 254 ALVCDVFK----RHGIGLVTLQPEF 274
            ++ D+ K    +  I  VTLQPEF
Sbjct: 261 QIIADIEKLLREKFYISHVTLQPEF 285


>UniRef50_A0B5Z8 Cluster: Cation diffusion facilitator family
           transporter; n=1; Methanosaeta thermophila PT|Rep:
           Cation diffusion facilitator family transporter -
           Methanosaeta thermophila (strain DSM 6194 / PT)
           (Methanothrixthermophila (strain DSM 6194 / PT))
          Length = 298

 Score = 52.0 bits (119), Expect = 2e-05
 Identities = 33/128 (25%), Positives = 62/128 (48%), Gaps = 3/128 (2%)

Query: 147 AGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           A SL VIAA L   W       ADP +S   ++++   +Y  ++ +  ++++ VPE +  
Sbjct: 157 AASLGVIAAALVI-WR-TGWYPADPIISLLISVMIFAGSYRLIKDSFRLIMEGVPECIRT 214

Query: 207 CDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKR-HGI 265
            ++        GV  +H+LH+W +    ++ +AHV+     D+ +  + + D      GI
Sbjct: 215 DEVVDQISTASGVIQVHDLHIWGVCSSNILLSAHVVVSPESDHQRTLSEIRDKLSSIFGI 274

Query: 266 GLVTLQPE 273
              T+Q E
Sbjct: 275 EHATIQLE 282


>UniRef50_Q99726 Cluster: Zinc transporter 3; n=23; Mammalia|Rep:
           Zinc transporter 3 - Homo sapiens (Human)
          Length = 388

 Score = 52.0 bits (119), Expect = 2e-05
 Identities = 39/129 (30%), Positives = 61/129 (47%), Gaps = 2/129 (1%)

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           L  S  V+AA +   ++ +  + ADP  +   +I  +    P +R    +L++  P  +G
Sbjct: 243 LLQSFGVLAASILIYFKPQY-KAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVG 301

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV-IYGTHEDYLKNSALVCDVFKRHG 264
              +R   L VPGV A HELH+W L     VA+AH+ I  T +     +     ++ R G
Sbjct: 302 FEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFG 361

Query: 265 IGLVTLQPE 273
               TLQ E
Sbjct: 362 FSSCTLQVE 370


>UniRef50_Q64SU7 Cluster: Cation efflux system protein; n=5;
           Bacteroidetes|Rep: Cation efflux system protein -
           Bacteroides fragilis
          Length = 302

 Score = 51.6 bits (118), Expect = 3e-05
 Identities = 50/231 (21%), Positives = 98/231 (42%), Gaps = 33/231 (14%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           + +S  LL D  H+L  +  L+  +++F+  +    +      R T+G+ +  V+    V
Sbjct: 42  YYDSLGLLSDAGHNLGDVASLVLAMLAFRLAKVHPNS------RYTYGYKKSTVL----V 91

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAIN------------ 142
            +L A   L  V   +   +     P P     I  +A +G++ NA+             
Sbjct: 92  SLLNAVILLVAVGIIITESIEKLFHPVPVEGAAIAWTAGVGVVINAVTAWLFMKDKEKDL 151

Query: 143 -----YMLLAG----SLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                Y+ +A     S+ V+ +G+   +      + DP +    A+++V+  +  +  + 
Sbjct: 152 NVKGAYLHMAADTLVSVGVVISGIIIMYT--GWTLVDPIIGLVIAVIIVISTWSLLHDSL 209

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYG 244
            + L  VP G+ +  +    L  PGV + H LH+W L   +   TAH++ G
Sbjct: 210 RLSLDGVPLGIDSEKIGRVILEQPGVESYHHLHIWALSTTETALTAHIVIG 260


>UniRef50_A0RLZ7 Cluster: Cation efflux family protein; n=1;
           Campylobacter fetus subsp. fetus 82-40|Rep: Cation
           efflux family protein - Campylobacter fetus subsp. fetus
           (strain 82-40)
          Length = 314

 Score = 51.6 bits (118), Expect = 3e-05
 Identities = 64/262 (24%), Positives = 110/262 (41%), Gaps = 36/262 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           TNS  L+ DT H L  ++ L   L  F    A   +  +     TFG+ R+E +      
Sbjct: 63  TNSLALMSDTLHMLSHVIAL--GLSWFAIWAASSFSSEQ----KTFGYHRLETIAAFINS 116

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN-AINYMLLAGSL--FV 152
           +L A F L +V  A+   ++    P P     ++  A IGL  N     ++L G +    
Sbjct: 117 ILIAVFGLFIVYEAIVKLIN----PEPIEIGTMLIVAAIGLGVNITTGLIMLKGDMGNLN 172

Query: 153 IAAGLTEEWEHEASRIA----------------DPALSACAAIVLVVFNYPFMRSAGLVL 196
           I +          S +A                D AL+   AI++  +++   R +  +L
Sbjct: 173 IKSSFAHMMSDLLSSVAIILGGIIVYFTNLWWIDSALALFIAIIIAKWSFSLARDSMNIL 232

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV 256
           L+  P  + A   +   L  P V  +H+LH+ ++     V TAH++    ++  K   ++
Sbjct: 233 LEASPIDINAA--KNVMLENPLVLDVHDLHISEITHKMYVLTAHIVL-NKDNIFKFDEII 289

Query: 257 CDVF----KRHGIGLVTLQPEF 274
            D+      R  IG +T+QPE+
Sbjct: 290 NDLSLSLKNRLEIGHITIQPEW 311


>UniRef50_A5WCY6 Cluster: Cation diffusion facilitator family
           transporter; n=2; Psychrobacter|Rep: Cation diffusion
           facilitator family transporter - Psychrobacter sp.
           PRwf-1
          Length = 359

 Score = 51.2 bits (117), Expect = 3e-05
 Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 5/131 (3%)

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           L GS+  I A L   W       ADP  S   A+++++  +  ++++  +L++  PE + 
Sbjct: 197 LLGSVAAIIAALAMMWM--GWWWADPVASVIVAVLILMSGFRVVKASTHILMEGTPEEIS 254

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDV---FKR 262
             D++        + A+H+LHVW +       + HV+       L+ S L+ ++    +R
Sbjct: 255 LDDVKHTIEHNEHIIAVHDLHVWSITSGLHALSCHVVVDGDMRILEASELIHELEHSLER 314

Query: 263 HGIGLVTLQPE 273
            GI   T+Q E
Sbjct: 315 LGISHTTIQVE 325


>UniRef50_A5DPS6 Cluster: Putative uncharacterized protein; n=1;
           Pichia guilliermondii|Rep: Putative uncharacterized
           protein - Pichia guilliermondii (Yeast) (Candida
           guilliermondii)
          Length = 427

 Score = 51.2 bits (117), Expect = 3e-05
 Identities = 41/159 (25%), Positives = 70/159 (44%), Gaps = 18/159 (11%)

Query: 169 ADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVW 228
           +DP +S     ++     P  R +  +LLQ  P  + +  +    + +P V +IH+ HVW
Sbjct: 269 SDPLVSLVITAIIFSSALPLCRRSSKILLQATPTDVNSNLVVEKIVSLPCVKSIHDFHVW 328

Query: 229 QLHRDKVVATAHV-IYGTHEDYLKNS-------------ALVCDVFKRHGIGLVTLQPEF 274
            L+ D ++A+ H+ +  T  + L N              A V ++   +GI   T+QPEF
Sbjct: 329 NLNEDILIASLHLELNDTETENLSNEEQQINKPAFVQAVAQVREILHAYGIHSATIQPEF 388

Query: 275 MLTSSRGTEEEKKELIAYGNLGCSCPCVKECTGPRCCEP 313
                 G +   K   AYG    S   + + +G   C+P
Sbjct: 389 S-DLRTGQQALTKRPSAYGATNKSSCVLDDVSG---CDP 423



 Score = 46.8 bits (106), Expect = 7e-04
 Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 8/108 (7%)

Query: 38  SPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHVL 97
           S  L+ D+ H L  ++ LI  L + + +      GR      T+GW R E++G L   V 
Sbjct: 58  SLALIADSFHMLNDIISLIIALWAVRVKNNKPADGRY-----TYGWQRAEILGALINAVF 112

Query: 98  FASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
             +    +++ A+Q  V     P    P++++G  + GLL N +  +L
Sbjct: 113 LLALCFTIIIEAIQRFVSP---PEISLPKLVLGVGIAGLLSNILGLVL 157


>UniRef50_UPI0000499CA1 Cluster: cation diffusion facilitator family
           protein; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
           cation diffusion facilitator family protein - Entamoeba
           histolytica HM-1:IMSS
          Length = 437

 Score = 50.4 bits (115), Expect = 6e-05
 Identities = 24/72 (33%), Positives = 39/72 (54%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP  S   ++V++V   P + S   +++Q VP+      +R + L  P V  +H+LH+WQ
Sbjct: 318 DPISSLIVSLVMMVSGMPLLYSCIRIVMQVVPKRFDLEKIRESILEHPDVVGVHDLHIWQ 377

Query: 230 LHRDKVVATAHV 241
           L+    VAT  V
Sbjct: 378 LNNKIGVATLKV 389


>UniRef50_Q4SHM2 Cluster: Chromosome 5 SCAF14581, whole genome
           shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
           Chromosome 5 SCAF14581, whole genome shotgun sequence -
           Tetraodon nigroviridis (Green puffer)
          Length = 402

 Score = 50.4 bits (115), Expect = 6e-05
 Identities = 34/127 (26%), Positives = 64/127 (50%), Gaps = 7/127 (5%)

Query: 115 HSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALS 174
           H + G P  +  + V +A I  L +      L  S+ V+ A     ++ E  ++ADP  +
Sbjct: 276 HGASGSPAPHGSMAVRAAFIHALGD------LFQSVGVLVAAYVVRFKPEL-KLADPICT 328

Query: 175 ACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDK 234
              +++++V     +R A +++L+ VP  L +  ++   L++  V A+ EL+VW L  DK
Sbjct: 329 YVFSVLVLVTTVRIIRDAMVIVLEGVPRHLDSLQMKEDLLKLDDVQAVDELNVWALTTDK 388

Query: 235 VVATAHV 241
             A  H+
Sbjct: 389 TAALVHL 395


>UniRef50_Q5FQH8 Cluster: Cation efflux system protein; n=1;
           Gluconobacter oxydans|Rep: Cation efflux system protein
           - Gluconobacter oxydans (Gluconobacter suboxydans)
          Length = 351

 Score = 50.4 bits (115), Expect = 6e-05
 Identities = 21/75 (28%), Positives = 40/75 (53%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I DP +S   ++ +V+  +  +RS+  + L  VP G+    ++ A L + GV  +H LH+
Sbjct: 230 IIDPIMSLIVSVSIVIGTWSLLRSSLNLALDAVPAGIDPDAVQAALLSLDGVSGLHHLHI 289

Query: 228 WQLHRDKVVATAHVI 242
           W +   +   T H++
Sbjct: 290 WAMSTTETALTVHLV 304


>UniRef50_Q2LY02 Cluster: Cobalt-zinc-cadmium resistance protein;
           n=1; Syntrophus aciditrophicus SB|Rep:
           Cobalt-zinc-cadmium resistance protein - Syntrophus
           aciditrophicus (strain SB)
          Length = 323

 Score = 50.4 bits (115), Expect = 6e-05
 Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 29/224 (12%)

Query: 38  SPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHVL 97
           S  L+ D  H+L     L   LIS+   R  E   R+  +  TFG+ RIEV+  L    L
Sbjct: 56  SMALISDALHNLSDFTSL---LISYVALRMGE---RQPTVSQTFGYKRIEVLAALVNVSL 109

Query: 98  FASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL-AGS------- 149
               A+ + +   Q  +     P     +++V  A+ GL  NA + +LL AG+       
Sbjct: 110 LYGVAIFIAIEGWQRLL----APQVIKGQLVVWIALAGLAGNAFSAVLLHAGAKTNINIR 165

Query: 150 ---LFVIAAGLTEE--------WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQ 198
              L ++   LT          W +      D  +S     ++    +  ++    +L+ 
Sbjct: 166 SSFLHMLTDALTSLGVVVLGIIWLYRPWYRLDTLVSWGIVALIFYGGWGILKETYQILMN 225

Query: 199 TVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
             P G+   +++ A   + G+  IH +HVW L  D+    AH+I
Sbjct: 226 ATPPGISVKEIKRAVEAIEGIREIHHIHVWTLSPDRAALAAHII 269


>UniRef50_Q4ECE6 Cluster: Cation efflux family protein; n=12;
           Rickettsiales|Rep: Cation efflux family protein -
           Wolbachia endosymbiont of Drosophila ananassae
          Length = 322

 Score = 49.6 bits (113), Expect = 1e-04
 Identities = 46/225 (20%), Positives = 104/225 (46%), Gaps = 30/225 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           ++S  LL D  H L  L  L+ + ++ ++      + ++  L+ ++G+ R++++      
Sbjct: 62  SHSLALLSDAGHMLTDLFALVLSWLAHRF------SAKKSDLQRSYGYHRLQIIAAFVNG 115

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL--------- 146
           +     A+ +++ +++  +     P     +V++  A +GL+ N I + +L         
Sbjct: 116 LTLFLIAVIIIIESIKRFIF----PVNVEWKVMLIIATLGLVSNIIVFFILHSKCESNIN 171

Query: 147 --AGSLFVIAAGLTEEWEHEAS--------RIADPALSACAAIVLVVFNYPFMRSAGLVL 196
             +  L VI   L       AS        +I DP LS   +++++   Y  ++++  +L
Sbjct: 172 IKSAVLHVIGDILGSVAAILASIIIMLTGWQIVDPILSVFVSVIILNSGYKILKNSCHIL 231

Query: 197 LQTVPEGLGACDLRT-AALRVPGVFAIHELHVWQLHRDKVVATAH 240
           L+  PEG+ A ++++     +P V  +H +H W L  +  + T H
Sbjct: 232 LEGTPEGISAEEIKSKITSELPEVIDVHHIHTWSLSDNYFIITMH 276


>UniRef50_Q9V471 Cluster: CG3994-PA, isoform A; n=3; Sophophora|Rep:
           CG3994-PA, isoform A - Drosophila melanogaster (Fruit
           fly)
          Length = 472

 Score = 49.6 bits (113), Expect = 1e-04
 Identities = 37/139 (26%), Positives = 64/139 (46%), Gaps = 6/139 (4%)

Query: 103 LALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWE 162
           +A V+     G H   GP     R  V   V   L + I  ++ +  +FV AAG+   W 
Sbjct: 290 IAAVLAETAPGSHHHGGP---VGREAVNMNVRAALIHVIGDVIQSVGVFV-AAGVIYFWP 345

Query: 163 HEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAI 222
             +  I DP  +   +I+++   +  M+ A LVL++  P  +   ++      + GV  +
Sbjct: 346 EYS--IVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYAEVLQIFQGIEGVERV 403

Query: 223 HELHVWQLHRDKVVATAHV 241
           H L +W L  +KV  +AH+
Sbjct: 404 HNLRIWALSINKVALSAHL 422


>UniRef50_Q01NK8 Cluster: Cation diffusion facilitator family
           transporter; n=1; Solibacter usitatus Ellin6076|Rep:
           Cation diffusion facilitator family transporter -
           Solibacter usitatus (strain Ellin6076)
          Length = 312

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 23/73 (31%), Positives = 39/73 (53%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP LS   A+++V   +  +R +  +LL+ +P G+   D+  A   V GV  +H+LH+W 
Sbjct: 182 DPVLSIVIALLIVWTAWDIIRESLNILLEGLPRGIHLVDVAKAMGGVTGVLGVHDLHIWS 241

Query: 230 LHRDKVVATAHVI 242
           L       + HV+
Sbjct: 242 LGSKTHALSCHVL 254


>UniRef50_A1IE74 Cluster: Cobalt-zinc-cadmium resistance protein;
           n=1; Candidatus Desulfococcus oleovorans Hxd3|Rep:
           Cobalt-zinc-cadmium resistance protein - Candidatus
           Desulfococcus oleovorans Hxd3
          Length = 331

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 60/226 (26%), Positives = 92/226 (40%), Gaps = 33/226 (14%)

Query: 38  SPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREG-RLRNTFGWARIEVVGRLSVHV 96
           S  L+ D  H+L     L+   +++   RA    GR G  LR++FG  R+E++  +    
Sbjct: 64  SVALISDAVHNLGDFASLV---VAYGAHRA----GRRGPSLRHSFGLQRMEILAAVINSA 116

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL---------- 146
           L    AL +   AL    +    P P    ++   A+ GL  N ++  LL          
Sbjct: 117 LLGGAALFIATEALDRLAN----PQPIRLGIVAWLALAGLAGNGLSAWLLHRDSARNLNA 172

Query: 147 -------AGSLFVIAAGLTEEWEHEASRIA--DPALSACAAIVLVVFNYPFM-RSAGLVL 196
                   G     AA LT       + +   DPALS  A +  + +N   + + A  VL
Sbjct: 173 RGAFLHMVGDTLTSAAVLTGALVMRVADMPWLDPALSL-AIVAYIAWNAVLLLKEATHVL 231

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
           +   P GL    +R     V GV ++H LH W +    V  T HV+
Sbjct: 232 MNGTPRGLDLEKVRADMEAVDGVLSVHYLHAWAMGGCSVAMTGHVV 277


>UniRef50_A5VLM8 Cluster: Cation diffusion facilitator family
           transporter; n=3; Lactobacillus|Rep: Cation diffusion
           facilitator family transporter - Lactobacillus reuteri
           F275
          Length = 306

 Score = 48.8 bits (111), Expect = 2e-04
 Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 24/189 (12%)

Query: 72  GREGRLRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGS 131
           G+    + T+G+ R E++  L+  +     ++ L++ A++   H  H        +++  
Sbjct: 61  GQPENRQRTYGYRRAEILSALTNSIFLIVISVFLIIEAIKRLEHPQH----INGGIMLTV 116

Query: 132 AVIGLLFNAINYMLL-AGS----------LFVIAAGLTEEWEHEASRIA--------DPA 172
           AVIGLL N I+  LL AGS          L +++  L+         I         DPA
Sbjct: 117 AVIGLLANFISAALLHAGSEDSLNVKATYLHILSDALSSVAVIIGGIILTFVNVPWLDPA 176

Query: 173 LSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHR 232
           L+   A+ +    +P +     +L+Q+ P+ L    +     ++ GV A+H +H W +  
Sbjct: 177 LTIGVALYIAYEAWPIINQTIKILMQSSPD-LDYNSIENDLKQIDGVTAVHHVHAWMMDE 235

Query: 233 DKVVATAHV 241
            +++ +AH+
Sbjct: 236 HRIIFSAHL 244


>UniRef50_Q8TRQ7 Cluster: Cation efflux system protein; n=2;
           Methanosarcina|Rep: Cation efflux system protein -
           Methanosarcina acetivorans
          Length = 291

 Score = 48.8 bits (111), Expect = 2e-04
 Identities = 51/232 (21%), Positives = 99/232 (42%), Gaps = 29/232 (12%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           TNS  LL D  H     + LI          A++   +    + TFG+ R+ ++      
Sbjct: 29  TNSLALLADAMHDFADSLALIVAWF------AEKKAKKPATSKMTFGYRRLSLLSAAFAT 82

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLF---- 151
           ++  + +L ++  A+   ++    P P     +   A+IG+  N + Y  L   +     
Sbjct: 83  IVLIAGSLFILSQAIPRLLN----PEPVNAEGMFLIAIIGVTINGLGYFRLKKGISQNEK 138

Query: 152 VIAAGLTEE---WE----------HEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQ 198
           +++  L E+   W                I DP ++    I ++   +   +    +LL+
Sbjct: 139 ILSWHLLEDILGWVVLLIGSVIIGFWNQPIIDPIMTIGFTIFVLWGVFKNAKETFNLLLE 198

Query: 199 TVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYL 250
            VPE +   +++ + L V G  A+H+LH+W L  +  + TAHV+    ++YL
Sbjct: 199 GVPEYIDIDEVKESILSVEGTKAVHDLHIWSLEGETDILTAHVV--VEDEYL 248


>UniRef50_UPI0000DAE80F Cluster: hypothetical protein
           Rgryl_01001334; n=1; Rickettsiella grylli|Rep:
           hypothetical protein Rgryl_01001334 - Rickettsiella
           grylli
          Length = 298

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 30/108 (27%), Positives = 55/108 (50%), Gaps = 7/108 (6%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +      ++   ++  +R +  ++L  VP G+ + ++ T    +PGV  +H+LH+W 
Sbjct: 180 DPIVGLLIVGIITWGSWNLLRRSVELILGAVPYGVDSKEIYTYLKNLPGVQEVHDLHIWG 239

Query: 230 LHRDKVVATAHVIYG----THEDYLKNSALVCDVFKRHGIGLVTLQPE 273
           L   +   TAH+I      + E+Y K + ++ + F    I  VTLQ E
Sbjct: 240 LSTQETALTAHLIMPETNLSDEEYFKINQVLAEKFH---IQHVTLQVE 284


>UniRef50_Q7NDR3 Cluster: Gll4169 protein; n=3; Bacteria|Rep:
           Gll4169 protein - Gloeobacter violaceus
          Length = 303

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 6/127 (4%)

Query: 148 GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGAC 207
           G++F  AA L   W        DP +S    +V+VV  +  +  +  + L  VPEG+   
Sbjct: 166 GTVFAGAAILLTGWAW-----LDPVVSLVIGVVIVVGTWGLLVDSLNLALDAVPEGIDPE 220

Query: 208 DLRTAALRVPGVFAIHELHVWQLHRDKVVATAH-VIYGTHEDYLKNSALVCDVFKRHGIG 266
            ++     + GV  +H+LH+W +   +   TAH VI G        +A    +  R GI 
Sbjct: 221 VVKAYLQSLRGVGEVHDLHIWAMSTTETALTAHLVIPGGFPGDAFLAATCRQLHDRFGIE 280

Query: 267 LVTLQPE 273
             TLQ E
Sbjct: 281 YATLQLE 287


>UniRef50_Q5ALP0 Cluster: Potential vacuolar cation transporter;
           n=4; Saccharomycetales|Rep: Potential vacuolar cation
           transporter - Candida albicans (Yeast)
          Length = 479

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 27/96 (28%), Positives = 51/96 (53%), Gaps = 3/96 (3%)

Query: 148 GSLFVIAAGLTEEWEHEASR--IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           G++ VI   L   W+ + S   +ADP  S    ++++    P +R A  +LLQ+ P  + 
Sbjct: 284 GNIGVIITALVI-WKTDYSWRFLADPITSLFITLIILNSALPLVRKASRILLQSAPPYID 342

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           +  +     ++P +  IH+ HVW L+ D ++A+ H+
Sbjct: 343 SNLIVNQIKQLPLIKNIHDFHVWNLNEDILIASLHI 378



 Score = 37.1 bits (82), Expect = 0.61
 Identities = 26/109 (23%), Positives = 51/109 (46%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  ++ LI  L + + +      G+      T+GW R E++G L   V
Sbjct: 30  HSLALIADSFHMLNDIISLIIALWAVRVKNTKPADGKY-----TYGWQRAEILGALINAV 84

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +    ++++++Q          P+   +IVG  + GL+ N +  +L
Sbjct: 85  FLLALCFTIIMDSIQRFFEPQEISNPKL-ILIVG--IAGLVSNGVGLVL 130


>UniRef50_A3LTE1 Cluster: Zinc-and cadmium resistance protein; n=1;
           Pichia stipitis|Rep: Zinc-and cadmium resistance protein
           - Pichia stipitis (Yeast)
          Length = 419

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 20/74 (27%), Positives = 40/74 (54%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           ++DP  S    +++     P  R +  +LLQ  P  + +  +    +++P V +IH+ HV
Sbjct: 265 VSDPVTSLVITLIIFSSALPLCRKSSKILLQATPPYINSNLIIEEIVKLPLVKSIHDFHV 324

Query: 228 WQLHRDKVVATAHV 241
           W L+ D ++A+ H+
Sbjct: 325 WNLNEDILIASLHI 338



 Score = 38.7 bits (86), Expect = 0.20
 Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 8/109 (7%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           +S  L+ D+ H L  ++ LI  L + + +      G+      T+GW R E++G L   V
Sbjct: 30  HSLALIADSFHMLNDIISLIIALWAVRVKNTKPADGKY-----TYGWQRAEILGALINAV 84

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
              +    +V++A+Q     +       P++I+   + GL  N +  +L
Sbjct: 85  FLLALCFTIVIDAIQRFFEPA---VITQPKLILVVGIAGLCSNGVGLVL 130


>UniRef50_Q0BUV7 Cluster: Cation efflux system protein; n=1;
           Granulibacter bethesdensis CGDNIH1|Rep: Cation efflux
           system protein - Granulobacter bethesdensis (strain ATCC
           BAA-1260 / CGDNIH1)
          Length = 344

 Score = 48.0 bits (109), Expect = 3e-04
 Identities = 61/268 (22%), Positives = 113/268 (42%), Gaps = 35/268 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  LL D  H +  ++ L+    + +  R    T      R+++G+ R+EV+      
Sbjct: 63  SGSLALLADAGHMVSDVLSLLMGWAALRIGRRPSST------RHSYGFRRLEVLAAFVNG 116

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL--------- 146
                 ++ +V+ A++  ++    P P    +++  A +GL+ NAI+ ++L         
Sbjct: 117 SSLLIVSIWIVIEAVRRLLN----PQPIGGGLMLAVAAVGLVANAISLLILNEGRESSLN 172

Query: 147 --------AGSLFVIAAGLTEEWEHEASR--IADPALSACAAIVLVVFNYPFMRSAGLVL 196
                      LF  AA +        +   IADP LS   A +++      ++ +  VL
Sbjct: 173 MRGVWLHVLSDLFGFAAAILAALIIMITGWVIADPLLSLIFAAMILRGAVSVVKGSAHVL 232

Query: 197 LQTVPEGLGACDLRTAALR-VPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSAL 255
           LQ  P  +    + +  +  +PGV  +H LH W L  +  + T H + G  E+  ++   
Sbjct: 233 LQGTPADIDLDAIASDLVHTIPGVQRVHHLHAWSLTGNDRLITLHAVTGAGEETGEDRDR 292

Query: 256 VCDVFK-----RHGIGLVTLQPEFMLTS 278
           + D  +     R GI   T+Q E  L S
Sbjct: 293 ILDAIQHRLSDRFGISHATVQMETGLRS 320


>UniRef50_A3UGA9 Cluster: Cation efflux protein; n=3;
           Proteobacteria|Rep: Cation efflux protein - Oceanicaulis
           alexandrii HTCC2633
          Length = 321

 Score = 48.0 bits (109), Expect = 3e-04
 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 4/97 (4%)

Query: 145 LLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGL 204
           LL     +IAAG+   W    + I DP LS   A ++ +  +  +R AG VLL+  P+ +
Sbjct: 185 LLGSVAAIIAAGVI--WWTGWTPI-DPLLSLLIAGLIGISAWRLVRDAGRVLLEAAPDHI 241

Query: 205 GACDLRT-AALRVPGVFAIHELHVWQLHRDKVVATAH 240
               LR      +  V  IH +HVW L  D+ +AT H
Sbjct: 242 DPSVLRADLTAEIEDVLDIHHVHVWSLTPDRPMATLH 278


>UniRef50_Q8EZ48 Cluster: Cobalt-zinc-cadmium resistance protein
           czcD; n=4; Leptospira|Rep: Cobalt-zinc-cadmium
           resistance protein czcD - Leptospira interrogans
          Length = 308

 Score = 47.6 bits (108), Expect = 4e-04
 Identities = 35/130 (26%), Positives = 59/130 (45%), Gaps = 9/130 (6%)

Query: 149 SLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACD 208
           SL VI +GL  +W        DP +     +V++  N P  R +  + L + PE + +  
Sbjct: 171 SLGVIISGLLIQWL--GFFWIDPVVGLLVGLVILYGNIPLFRQSLRLSLDSTPETIQSGI 228

Query: 209 LRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGT-----HEDYLKNSALVCDVFKRH 263
           +      + GV  IH +H+W L   +   TAH++        H+  +K+ A   ++ K  
Sbjct: 229 VEKELKSIEGVLNIHHIHIWSLSTTENALTAHLVLKNDLTFEHQRIIKSKAR--EILKGL 286

Query: 264 GIGLVTLQPE 273
            I  VTL+ E
Sbjct: 287 KIEHVTLETE 296


>UniRef50_Q04D37 Cluster: Co/Zn/Cd efflux system component; n=2;
           Oenococcus oeni|Rep: Co/Zn/Cd efflux system component -
           Oenococcus oeni (strain BAA-331 / PSU-1)
          Length = 296

 Score = 47.6 bits (108), Expect = 4e-04
 Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 6/139 (4%)

Query: 149 SLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACD 208
           SL V+ AG    + +    I DP +S  AA+ ++  ++  +  A  ++   VP+ +   +
Sbjct: 162 SLCVVFAGFIINFTNWV--ILDPLVSIFAAVFILFESWRVLCHAFSLVTNGVPDNISENE 219

Query: 209 LRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCD-VFKRHGIGL 267
           +    L  P +  I+++H+W L   +V  +AH+      DY+K      D + K+  I  
Sbjct: 220 VEKYLLSFPEIEKINDVHIWALSTTEVAISAHLQCNRPADYMKILDDATDGLRKKFDIDH 279

Query: 268 VTLQPEFMLTSSRGTEEEK 286
           VTLQ E   TS +  +E K
Sbjct: 280 VTLQLE---TSDKKHKESK 295


>UniRef50_A0FTM8 Cluster: Cation diffusion facilitator family
           transporter; n=5; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Burkholderia phymatum
           STM815
          Length = 373

 Score = 47.6 bits (108), Expect = 4e-04
 Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 1/112 (0%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +S     V+V   +  +R +  + L  VP G+    +R      PGV  +H+LHVW 
Sbjct: 252 DPVMSLVVVAVIVYGTWGLLRDSLSLALNGVPRGVDMQKIRAYLAAQPGVTDVHDLHVWA 311

Query: 230 LHRDKVVATAH-VIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPEFMLTSSR 280
           L       +AH VI G H       A+V  +     +   TLQ +   T  R
Sbjct: 312 LSTTGNALSAHLVIPGGHPGDRVIDAIVGTLRTEFDMHHATLQVDMGTTQHR 363


>UniRef50_Q2UAQ9 Cluster: Zn2+ transporter ZNT1 and related
           Cd2+/Zn2+ transporters; n=1; Aspergillus oryzae|Rep:
           Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters
           - Aspergillus oryzae
          Length = 413

 Score = 47.6 bits (108), Expect = 4e-04
 Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 7/99 (7%)

Query: 215 RVPGVFAIHELHVWQLHRDKVVATAHVIYG--THEDYLKNSALVCDVFKRHGIGLVTLQP 272
           ++P V +IHELH W+L+++K +A+ HV        +++K +  + + F  +GI    +QP
Sbjct: 319 QLPEVSSIHELHAWRLNQEKALASVHVGLPDIRISEFVKLAKTMNECFHSYGIHSAIVQP 378

Query: 273 EFMLTSSRGTEEEKKELIAYGNLGCSCPCVKECTGPRCC 311
           E + T    TE  + +     +  C   C   C    CC
Sbjct: 379 ELVQTVEDTTEGTETK-----SDSCQITCGSSCELLTCC 412


>UniRef50_UPI0000D5546C Cluster: PREDICTED: similar to solute
           carrier family 30, member 2 isoform 1; n=2;
           Endopterygota|Rep: PREDICTED: similar to solute carrier
           family 30, member 2 isoform 1 - Tribolium castaneum
          Length = 429

 Score = 47.2 bits (107), Expect = 6e-04
 Identities = 36/152 (23%), Positives = 69/152 (45%), Gaps = 13/152 (8%)

Query: 96  VLFASFALALVVNALQ-LGVHS---SHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLF 151
           V+  +  + ++VN +  L +H    SHG    +    +   V     + I   L +  +F
Sbjct: 178 VMLITSGIGVIVNLIMGLTLHQHGHSHGGGSTHSHDNIN--VRAAFIHVIGDFLQSFGVF 235

Query: 152 VIAAGL--TEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDL 209
           V AA +   E+W      I DP  +   +++++   +  ++    VL++  P+G+    +
Sbjct: 236 VAAAVIYFNEQWV-----IIDPICTFIFSVLVMFTTFNIIKDTLTVLMEGAPKGIDFNQV 290

Query: 210 RTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
               L + GV  +H L +W L  DK+  +AHV
Sbjct: 291 MKTLLNIEGVKRVHNLRIWGLSLDKIAMSAHV 322


>UniRef50_Q1II24 Cluster: Cation diffusion facilitator family
           transporter; n=1; Acidobacteria bacterium Ellin345|Rep:
           Cation diffusion facilitator family transporter -
           Acidobacteria bacterium (strain Ellin345)
          Length = 312

 Score = 47.2 bits (107), Expect = 6e-04
 Identities = 53/224 (23%), Positives = 89/224 (39%), Gaps = 28/224 (12%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           ++S  LL +  H+L   + L+ T ++   +       R      TFG+ R    G L+  
Sbjct: 39  SHSLALLSEAGHNLSDFLALLLTWVAVYVQ------SRPPSATKTFGYQR---AGVLAAF 89

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN-AINYMLLA------- 147
           +  AS  L       + G    + P    PR ++  A  G++ N AI  MLL        
Sbjct: 90  INAASLVLIAFFIFYEAG-RRLYAPSDVEPRTMMWVAACGVVMNGAIALMLLRTRRDLNI 148

Query: 148 --------GSLFVIAAGLTEEWE--HEASRIADPALSACAAIVLVVFNYPFMRSAGLVLL 197
                   G     AA +   W          DPALS    ++++  ++  +R +  +LL
Sbjct: 149 RSAFLHELGDTLSTAAVIVGGWVILETGQSWVDPALSFGIGVLVLWSSFGVIRDSLNILL 208

Query: 198 QTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           +  P G+    L      + GV  +H+LHVW L  +    + H+
Sbjct: 209 EGTPRGMNVQRLAERMCSIDGVIDVHDLHVWSLGSETHALSCHI 252


>UniRef50_A0JRX0 Cluster: Cation diffusion facilitator family
           transporter; n=5; Actinomycetales|Rep: Cation diffusion
           facilitator family transporter - Arthrobacter sp.
           (strain FB24)
          Length = 308

 Score = 47.2 bits (107), Expect = 6e-04
 Identities = 29/97 (29%), Positives = 49/97 (50%), Gaps = 2/97 (2%)

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           L GS  VIAA +         + AD   S   A++++   +  +R    VLL+  P+G+ 
Sbjct: 165 LLGSFAVIAAAVVIMVT--GFQAADTIASMVIAVMILPRAWHLLRDVVDVLLEATPKGVE 222

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
              +R   L V GV ++H++H+W +     V +AHV+
Sbjct: 223 VQMIREHILSVHGVVSVHDIHIWTITSGVPVFSAHVV 259


>UniRef50_Q8TCH2 Cluster: Zinc transporter-like 2 protein; n=37;
           Eumetazoa|Rep: Zinc transporter-like 2 protein - Homo
           sapiens (Human)
          Length = 376

 Score = 47.2 bits (107), Expect = 6e-04
 Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 8/131 (6%)

Query: 148 GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMR-SAGLVLLQTVP---EG 203
           GS+ VIA+ +    ++    IADP  S   AI++VV   P +R S G+++ +T P     
Sbjct: 247 GSIGVIASAIM--MQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENS 304

Query: 204 LGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRH 263
           L  C  R   L+  G +++ E H W L  D  V T  +I     D     +   ++F + 
Sbjct: 305 LPQCYQRVQQLQ--GAYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFTQA 362

Query: 264 GIGLVTLQPEF 274
           G+  + +Q +F
Sbjct: 363 GVRQLYVQIDF 373


>UniRef50_Q9ZT63 Cluster: Metal tolerance protein 1 (AtMTP1) (Zinc
           transporter ZAT-1) (ZAT1p) [Contains: Metal tolerance
           protein 1 short form]; n=31; Magnoliophyta|Rep: Metal
           tolerance protein 1 (AtMTP1) (Zinc transporter ZAT-1)
           (ZAT1p) [Contains: Metal tolerance protein 1 short form]
           - Arabidopsis thaliana (Mouse-ear cress)
          Length = 398

 Score = 47.2 bits (107), Expect = 6e-04
 Identities = 30/114 (26%), Positives = 52/114 (45%), Gaps = 1/114 (0%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           W +   +I D   +   +++++      +R+   VL+++ P  + A  L    L +  V 
Sbjct: 284 WYNPEWKIVDLICTLAFSVIVLGTTINMIRNILEVLMESTPREIDATKLEKGLLEMEEVV 343

Query: 221 AIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKR-HGIGLVTLQPE 273
           A+HELH+W +   KV+   HV      D       V D  +R + I  VT+Q E
Sbjct: 344 AVHELHIWAITVGKVLLACHVNIRPEADADMVLNKVIDYIRREYNISHVTIQIE 397


>UniRef50_Q1Q6G6 Cluster: Strongly similar to cation (Co/Zn/Cd)
           diffusion facilitator family protein; n=1; Candidatus
           Kuenenia stuttgartiensis|Rep: Strongly similar to cation
           (Co/Zn/Cd) diffusion facilitator family protein -
           Candidatus Kuenenia stuttgartiensis
          Length = 302

 Score = 46.8 bits (106), Expect = 7e-04
 Identities = 51/226 (22%), Positives = 97/226 (42%), Gaps = 30/226 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           TNS  LL D  H L  L  L+ +L +  +        +    R T+G+ R+E++  L   
Sbjct: 20  TNSLALLSDAGHMLTHLFALLISLFAIMF------ASKPPTQRKTYGFYRLEILAALLNG 73

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN-AINYMLLAG----SL 150
           ++     L + V       H    P      ++   A+IGLL N +  Y+L +G    SL
Sbjct: 74  IIL----LLITVWIFYEAYHRFVTPEAISSGMMFFLAIIGLLANISCVYILKSGEHGHSL 129

Query: 151 FVIAAGLTEEWEHEAS---------------RIADPALSACAAIVLVVFNYPFMRSAGLV 195
            V +A L    +  +S                I DP +S    I++++++Y  +  +  +
Sbjct: 130 NVKSAFLHMLGDTISSVGVIIGAVIIYYTNWYIIDPIISIMLCILILIWSYKLIMESVDI 189

Query: 196 LLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           LL+  P+ +   ++ +   ++ GV   H++H+W +       + H+
Sbjct: 190 LLEATPKDINVGEVISQLEQITGVDGAHDIHIWTITSGMYAMSVHI 235


>UniRef50_UPI00006CA446 Cluster: cation diffusion facilitator family
           transporter containing protein; n=1; Tetrahymena
           thermophila SB210|Rep: cation diffusion facilitator
           family transporter containing protein - Tetrahymena
           thermophila SB210
          Length = 549

 Score = 46.4 bits (105), Expect = 0.001
 Identities = 31/141 (21%), Positives = 65/141 (46%), Gaps = 6/141 (4%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSA 192
           V+G L  +I  ++ A  ++ +       + H    +ADP  +   +I++++         
Sbjct: 396 VLGDLLQSIGVLIAAFLIYFLGGDDGFNYWH----LADPICTYIFSILVLLTTKNVSIDC 451

Query: 193 GLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKN 252
             VL++  P  +   + +   L++  V  IH+LH+WQL + K   T H+    +   + N
Sbjct: 452 FKVLMEGTPSQIDVQNFKEKLLKIANVMEIHDLHIWQLSQGKPSLTCHIFISENPREVLN 511

Query: 253 SALVCDVFKRHGIGLVTLQPE 273
                ++ +++GI   T+Q E
Sbjct: 512 K--TTELCRQYGIYHSTIQIE 530


>UniRef50_Q74FW5 Cluster: Cation efflux family protein; n=7;
           Desulfuromonadales|Rep: Cation efflux family protein -
           Geobacter sulfurreducens
          Length = 331

 Score = 46.4 bits (105), Expect = 0.001
 Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 36/263 (13%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           +TNS  LL D  H    L  L+ +L + K         +      TFGW R EV      
Sbjct: 35  WTNSLALLSDAAHVFLDLFALVLSLAAIKLASYPASDTK------TFGWHRAEVFASFIN 88

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG----SL 150
                  AL +   A+  G   +       P +++  A +GL+ N I+   L G     L
Sbjct: 89  GATVFLMALGIFYEAV--GRLMNPEAVKSLPMLLI--ATLGLVMNLISATALHGHSHDDL 144

Query: 151 FVIAAGLTEEWEHEAS---------------RIADPALSACAAIVLVVFNYPFMRSAGLV 195
            V +A L    +  AS                + D  +S     V+   ++  +R A  +
Sbjct: 145 NVRSAFLHVVGDAAASVGVIVGGLIMYFTGWYVLDALISIGIGCVIFAGSWRVLREAAHI 204

Query: 196 LLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV-----IYGTHEDYL 250
           LL+ VP G+    +      V GV A+H++++W +    +  +AHV       G   + L
Sbjct: 205 LLEGVPRGMSTQQVANEMAGVEGVNAVHQMNIWTICSHILALSAHVDVKPEYKGQQAEVL 264

Query: 251 KNSALVCDVFKRHGIGLVTLQPE 273
           +    +  +F+R+ I   TLQ E
Sbjct: 265 RQIEQL--LFERYHITHTTLQAE 285


>UniRef50_A4SX31 Cluster: Cation diffusion facilitator family
           transporter; n=1; Polynucleobacter sp. QLW-P1DMWA-1|Rep:
           Cation diffusion facilitator family transporter -
           Polynucleobacter sp. QLW-P1DMWA-1
          Length = 626

 Score = 46.4 bits (105), Expect = 0.001
 Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 1/105 (0%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           D  LS   +++++      +  +   L++ VP  +    +      VPGV A+H+LHVW+
Sbjct: 211 DAILSILVSLLILKSTISILHESYHFLMEGVPLHIDYLAVGRDLKAVPGVLAVHDLHVWE 270

Query: 230 LHRDKVVATAHVIYGTHEDYLKNSALV-CDVFKRHGIGLVTLQPE 273
           +         H+     +++    A +   +  +HGI  VTLQPE
Sbjct: 271 MTPSFPALIGHIEISDMQEWPSIMAKINAMLLDKHGIDHVTLQPE 315


>UniRef50_Q8ERA7 Cluster: Cation efflux system permease; n=14;
           Bacillaceae|Rep: Cation efflux system permease -
           Oceanobacillus iheyensis
          Length = 300

 Score = 46.0 bits (104), Expect = 0.001
 Identities = 55/232 (23%), Positives = 92/232 (39%), Gaps = 43/232 (18%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRN-TFGWARIEVVGRLSV 94
           TNS  LL D  H L     L  TL++F         G +    N TFG+ R E++     
Sbjct: 40  TNSLALLSDAGHMLSDAAALGLTLLAFNI-------GEKSITANKTFGYKRFEIIAAFIN 92

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA------- 147
            V     ++ + + AL+  V      PP     ++  A IG   N +   LL        
Sbjct: 93  GVTLILISIFIFIEALRRFVE-----PPEVSGAMMIIAFIGFCVNILVAWLLMKGNAEEN 147

Query: 148 ---------------GSLFVIAAG---LTEEWEHEASRIADPALSACAAIVLVVFNYPFM 189
                          GS+  + AG   L   W      IADP  S   AI++++      
Sbjct: 148 LNLKSALLHVMGDLLGSIGALVAGALILLFNWN-----IADPIASIIVAILIIISGIRIT 202

Query: 190 RSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           + +  +L++  P  +   +++ + L + GV  +H+LHVW +  +    + H+
Sbjct: 203 KDSLHILMEGKPTNVNIDEMKRSLLSLSGVQDVHDLHVWSITSEFPSMSCHI 254


>UniRef50_Q8U3B2 Cluster: Cation efflux system protein; n=5;
           cellular organisms|Rep: Cation efflux system protein -
           Pyrococcus furiosus
          Length = 295

 Score = 46.0 bits (104), Expect = 0.001
 Identities = 62/264 (23%), Positives = 109/264 (41%), Gaps = 42/264 (15%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  L  D+ H+    + ++T+ I+ K         RE   + TFG+ R E++      
Sbjct: 33  SRSLALFSDSLHNFSDSMSILTSYIAIKIGE------REKNEKYTFGYKRAEILVAFVNS 86

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL--------- 146
            +    AL L+V A +        P P    ++   A+IG L N I+ +LL         
Sbjct: 87  AILVGVALFLIVEAYK----RFKTPEPINGPLMFSVALIGFLANLISVLLLHEHSHENIN 142

Query: 147 ------------AGSLFVIAAGLTE-EWEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                         S+ V+  G+   +W    +   DP LSA  +I ++   Y  ++ + 
Sbjct: 143 VRSAYLHLLSDTLSSVAVVLGGIAIIKWN---AIWVDPLLSALISIYILREAYEILKESV 199

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNS 253
            VL++  P  L   +++     +PGV   H  H W++   +V    HV    ++  +  +
Sbjct: 200 EVLMEASPN-LDFNEIKREIESIPGVKNAHHFHAWRVGEKEVHFECHV--EVNDMLISEA 256

Query: 254 ALVCDV----FKRHGIGLVTLQPE 273
             + DV     +R GI  VT+Q E
Sbjct: 257 QQIIDVIAERLRRFGITHVTVQLE 280


>UniRef50_Q9BRI3 Cluster: Zinc transporter 2; n=34; Eumetazoa|Rep:
           Zinc transporter 2 - Homo sapiens (Human)
          Length = 323

 Score = 46.0 bits (104), Expect = 0.001
 Identities = 23/82 (28%), Positives = 41/82 (50%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           +  DP  +   +I+++      +R   LVL++  P+G+    +R   L V GV A+H LH
Sbjct: 199 KYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVRDLLLSVEGVEALHSLH 258

Query: 227 VWQLHRDKVVATAHVIYGTHED 248
           +W L   + V + H+    + D
Sbjct: 259 IWALTVAQPVLSVHIAIAQNTD 280


>UniRef50_Q95QW4 Cluster: Cation diffusion facilitator family
           protein 1; n=3; Caenorhabditis|Rep: Cation diffusion
           facilitator family protein 1 - Caenorhabditis elegans
          Length = 561

 Score = 45.6 bits (103), Expect = 0.002
 Identities = 33/137 (24%), Positives = 63/137 (45%), Gaps = 7/137 (5%)

Query: 138 FNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLL 197
           F ++  M+ AG ++ +       W+  A    DP LS   A ++       ++++G  LL
Sbjct: 397 FGSVIVMISAGFVYFLPT-----WKIAA--YLDPILSISLASIMGFTAVVLVKTSGEKLL 449

Query: 198 QTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVC 257
           +  PEGL    ++     + GV  + +L VW L   +++A AHV       + + +  + 
Sbjct: 450 KQTPEGLDLEKVKKDLCSIVGVSKVEKLSVWTLCGQRIIAAAHVNICHPAVFPEAAYKIK 509

Query: 258 DVFKRHGIGLVTLQPEF 274
           + F   G+   T++P F
Sbjct: 510 NYFHDLGVHSTTIEPTF 526


>UniRef50_Q4REH2 Cluster: Chromosome 10 SCAF15123, whole genome
           shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 10
           SCAF15123, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 368

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 38/148 (25%), Positives = 70/148 (47%), Gaps = 10/148 (6%)

Query: 99  ASFALALVVNALQLGVHSSHGPPPRYP----RVIVGSAVIGLLFNAINYMLLAGSLFVIA 154
           A+  +AL+++  Q GV    G  P+      R   G+A +   F  +   L+     ++A
Sbjct: 188 ANILMALILH--QSGVSHGDGHRPKQHQQQGRCNHGNASVRAAFVHVVGDLVQSVGVLLA 245

Query: 155 AGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAA 213
           A +   W E++A   ADP  +   + +++   +P  +    +L++  P  + A  +R   
Sbjct: 246 AVVIHFWPEYKA---ADPICTFLFSALVLGTTFPVAKDVFRILMEGAPRDVCADSVRKQL 302

Query: 214 LRVPGVFAIHELHVWQLHRDKVVATAHV 241
           L V GV  +H LHVW L+  + + + HV
Sbjct: 303 LSVRGVADVHRLHVWSLNATQPLLSVHV 330


>UniRef50_A6SYW0 Cluster: Cobalt-zinc-cadmium resistance protein
           CzcD; n=1; Janthinobacterium sp. Marseille|Rep:
           Cobalt-zinc-cadmium resistance protein CzcD -
           Janthinobacterium sp. (strain Marseille) (Minibacterium
           massiliensis)
          Length = 316

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 56/227 (24%), Positives = 92/227 (40%), Gaps = 31/227 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           T S  LL D  H L     L   LI+ +  +      R    R TFG+ R E++      
Sbjct: 39  TGSLALLSDAAHMLTDASALAIALIAIQIAK------RAADSRRTFGYHRFEILAASFNA 92

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAG----SLF 151
           ++    A+ ++  A +     S         +I+ S  +GL+ N I+  LL+     SL 
Sbjct: 93  IMLFFVAMYILYEAYRR--FKSPIEIQSMGMLIIAS--LGLIINLISMKLLSSGKDASLN 148

Query: 152 VIAAGLTEEWEHEASRIA----------------DPALSACAAIVLVVFNYPFMRSAGLV 195
           +  A L E W      +                 D  ++      ++   +  +R +  V
Sbjct: 149 IKGAYL-EVWSDMLGSVGVIAGALIIRFTGWTWVDSVIAVGIGFWVLPRTWILLRESINV 207

Query: 196 LLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
           LL+ VPE +    LR +   + GV +IH+LHVW +   K+  T HV+
Sbjct: 208 LLEGVPEHIDLEKLRKSVSDIAGVRSIHDLHVWSITSGKISLTMHVV 254


>UniRef50_Q7PWD5 Cluster: ENSANGP00000006521; n=1; Anopheles gambiae
           str. PEST|Rep: ENSANGP00000006521 - Anopheles gambiae
           str. PEST
          Length = 422

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 26/93 (27%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 149 SLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACD 208
           SL V  A L   ++ E + I DP  +   +++++      MR A +VL++  P+ L   +
Sbjct: 283 SLGVFIAALVIYFKPEWN-IIDPICTFLFSVLVLGTTLAIMRDAIVVLMEGTPKYLDYTE 341

Query: 209 LRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           +    L++ GV  +H L +W L  +K+   AH+
Sbjct: 342 VMQTFLQIEGVVRVHNLRIWALSINKIALAAHL 374


>UniRef50_A0DLG1 Cluster: Chromosome undetermined scaffold_55, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_55,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 574

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 34/146 (23%), Positives = 68/146 (46%), Gaps = 6/146 (4%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEAS--RIADPALSACAAIVLVVFNYPFMR 190
           VIG +  +I  ++ A  +++      E  E   +  + ADP  +   +I+++   +   +
Sbjct: 415 VIGDILQSIGVLIAAILIYIFGQKKDENNEIVFTYWQYADPLCTYLFSILVLFTTFGVAK 474

Query: 191 SAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDY- 249
               VL++  P  L   + R     +  V  +H+LH+W L   K   +AH++   + +Y 
Sbjct: 475 ECVRVLMEGTPTNLIIEEFRDRLNAIHRVREVHDLHIWSLSVGKPAMSAHIVCLENPEYV 534

Query: 250 LKNSALVCDVFKRHGIGLVTLQPEFM 275
           LK +  +C   ++ GI   T+Q E +
Sbjct: 535 LKKATKLC---RKFGIYHSTIQIELL 557


>UniRef50_Q5L2G4 Cluster: Cation efflux transporter; n=5;
           Bacillaceae|Rep: Cation efflux transporter - Geobacillus
           kaustophilus
          Length = 315

 Score = 44.8 bits (101), Expect = 0.003
 Identities = 25/104 (24%), Positives = 52/104 (50%), Gaps = 2/104 (1%)

Query: 148 GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGAC 207
           GS+  I AGL   W   +  +ADP +S   A++++   +  ++    +L++  P  +   
Sbjct: 180 GSVGAIIAGLVM-WLF-SWYVADPIISILVALLILKGAWGVIKHTVHILMEGTPITIDQN 237

Query: 208 DLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLK 251
           +++ A   + GV  +H+LH+W +       + H++   H+D  K
Sbjct: 238 EVKKALESIEGVINVHDLHIWTITSGLDSLSCHILIEDHQDSQK 281


>UniRef50_Q2GIB0 Cluster: Cation efflux family protein; n=1;
           Anaplasma phagocytophilum HZ|Rep: Cation efflux family
           protein - Anaplasma phagocytophilum (strain HZ)
          Length = 301

 Score = 44.8 bits (101), Expect = 0.003
 Identities = 20/76 (26%), Positives = 40/76 (52%), Gaps = 1/76 (1%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDL-RTAALRVPGVFAIHEL 225
           +I DP LS   + V+++  +  ++++  +LL+  P  +   +L R     +P V  +H +
Sbjct: 181 QIIDPMLSLLVSTVMLISAFSIVKNSSNILLEGKPYNIDVGELQRNITSAIPNVIDVHHV 240

Query: 226 HVWQLHRDKVVATAHV 241
           H+W L  +  + T HV
Sbjct: 241 HLWSLTAEYPIMTMHV 256


>UniRef50_A7NYR7 Cluster: Chromosome chr6 scaffold_3, whole genome
           shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
           chr6 scaffold_3, whole genome shotgun sequence - Vitis
           vinifera (Grape)
          Length = 382

 Score = 44.8 bits (101), Expect = 0.003
 Identities = 22/91 (24%), Positives = 43/91 (47%), Gaps = 2/91 (2%)

Query: 152 VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRT 211
           ++A G+   W      + D   + C +++++      +R+   +L++  P  +    L  
Sbjct: 262 MVAGGII--WAKPEWLMVDLVCTLCFSVLVLTTTLTMLRNIFSILMERAPIEIDIAGLEN 319

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
               + GV  +H+LHVW +   KVV + HVI
Sbjct: 320 GLKSIKGVQDVHDLHVWAITVGKVVMSCHVI 350


>UniRef50_Q5CSE6 Cluster: Cation diffusion facilitator like membrane
           protein transporter, 6x transmembrane domains; n=2;
           Cryptosporidium|Rep: Cation diffusion facilitator like
           membrane protein transporter, 6x transmembrane domains -
           Cryptosporidium parvum Iowa II
          Length = 459

 Score = 44.8 bits (101), Expect = 0.003
 Identities = 27/124 (21%), Positives = 59/124 (47%), Gaps = 2/124 (1%)

Query: 152 VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRT 211
           V+ AGL   + + A  IADP  +   +  ++      ++ +  VL++  P G+    ++ 
Sbjct: 299 VMIAGLLILY-NPAWTIADPLCTILFSFFVLATTIKILKDSANVLMEGTPIGIDCESIQN 357

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVF-KRHGIGLVTL 270
             L++  V  +H+LHVW +       + H++  + ++         D+  K++GI   T+
Sbjct: 358 DFLKLSSVLEVHDLHVWSVSVGVPALSCHIVVASEDNARFTLRYATDLCQKKYGIFHTTI 417

Query: 271 QPEF 274
           Q ++
Sbjct: 418 QIDY 421


>UniRef50_Q54QU8 Cluster: Putative uncharacterized protein; n=2;
           cellular organisms|Rep: Putative uncharacterized protein
           - Dictyostelium discoideum AX4
          Length = 543

 Score = 44.8 bits (101), Expect = 0.003
 Identities = 18/81 (22%), Positives = 41/81 (50%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           W H   +IADP  +   +++++      +R +  VL++ VP  +   +++     + GV 
Sbjct: 396 WVHPHWKIADPITTLIFSVIVLGTTIKLLRESLGVLMEGVPPEIDVSEVKGDLSEIEGVT 455

Query: 221 AIHELHVWQLHRDKVVATAHV 241
            +H+LH+W +   +   + H+
Sbjct: 456 EVHDLHIWSITLGRPALSVHL 476


>UniRef50_Q83BX5 Cluster: Cation-efflux family protein; n=2;
           Coxiella burnetii|Rep: Cation-efflux family protein -
           Coxiella burnetii
          Length = 378

 Score = 44.4 bits (100), Expect = 0.004
 Identities = 38/165 (23%), Positives = 72/165 (43%), Gaps = 12/165 (7%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           F +S  L+ D  HSL  L  L   L+        +   +E    + +G  RIE +G + +
Sbjct: 37  FGHSQALIADGVHSLSDL--LTDGLVVVTGHMGAQSPDKE----HPYGHRRIETIGSIII 90

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN--AINYMLLAGSLFV 152
            V+    A+ +  + L+  +H +H P P +P +IV  AVI ++ N     Y L  G+   
Sbjct: 91  AVILIFVAIGIAFDTLEHLIHHAHLPLPTFPVIIV--AVISIIANEGLFRYTLAKGNQIN 148

Query: 153 IAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLL 197
                T  W + +  +   +L    +++   F   ++ + G  ++
Sbjct: 149 SDLLRTNAWHNRSDSLV--SLIVLISVIGSRFGITYLDAIGAFII 191


>UniRef50_A7RHI7 Cluster: Predicted protein; n=1; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 293

 Score = 44.4 bits (100), Expect = 0.004
 Identities = 25/97 (25%), Positives = 48/97 (49%), Gaps = 1/97 (1%)

Query: 152 VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRT 211
           V+ AGL  + + E  + AD   S   A++++V  Y  +R +  +L + VP  +   +++ 
Sbjct: 172 VLLAGLIIKIKPEWQK-ADAICSLVGAVIVLVTTYAVIRDSFNILFEGVPRDVRIAEVKR 230

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED 248
               +  V + H +HVW L   + + TAH++     D
Sbjct: 231 DLSTLHHVVSFHNVHVWALTSGRNLLTAHLVVEPEAD 267


>UniRef50_Q606W3 Cluster: Cation efflux family protein; n=2;
           Bacteria|Rep: Cation efflux family protein -
           Methylococcus capsulatus
          Length = 314

 Score = 44.0 bits (99), Expect = 0.005
 Identities = 20/73 (27%), Positives = 38/73 (52%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DPA+S   A++++      M     +LL++ P  +    +    ++V GV  +H LHVW 
Sbjct: 185 DPAVSVLIALLILWNAKGLMAEVMDILLESTPRDVDMGSMVRDMMQVEGVHGVHHLHVWS 244

Query: 230 LHRDKVVATAHVI 242
           + R   + +AH++
Sbjct: 245 ISRQLRMLSAHIV 257


>UniRef50_Q1H0B4 Cluster: Cation diffusion facilitator family
           transporter; n=1; Methylobacillus flagellatus KT|Rep:
           Cation diffusion facilitator family transporter -
           Methylobacillus flagellatus (strain KT / ATCC 51484 /
           DSM 6875)
          Length = 325

 Score = 44.0 bits (99), Expect = 0.005
 Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 1/105 (0%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP LS   +++++V     +     VL++ VP  L    +  A      V  +H LH+W 
Sbjct: 183 DPILSIFISVLILVSTLRLLGEVLHVLMEGVPLHLDIQAVEHAMSASDKVQGVHHLHIWS 242

Query: 230 LHRDKVVATAHVIYGTHEDYLK-NSALVCDVFKRHGIGLVTLQPE 273
           L  +K   +AH++     D+ +  + L   + +R  I  VTLQPE
Sbjct: 243 LSSEKTALSAHIVLENILDWHEVLNNLRHMLHERFNIEHVTLQPE 287


>UniRef50_A1RH26 Cluster: Cation diffusion facilitator family
           transporter; n=4; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Shewanella sp. (strain
           W3-18-1)
          Length = 342

 Score = 44.0 bits (99), Expect = 0.005
 Identities = 54/227 (23%), Positives = 92/227 (40%), Gaps = 32/227 (14%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVV-GRLSV 94
           + S  LL D  H L     L     +F++ R      R    + TFG+ R EV+ G L+ 
Sbjct: 47  SGSLALLADAGHMLTDAAALALAYAAFRFGR------RPADSKRTFGYLRFEVIAGFLNA 100

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAI----------NYM 144
             LF   A  +   A +        PP      ++  AV+GLL N +          +++
Sbjct: 101 VTLFVIVAW-IAYEAWE----RLQAPPAILAGPMMIVAVLGLLVNVLVLWIMTRGETDHV 155

Query: 145 LLAGSLFVIAAGLTEEWEHEASRIA---------DPALSACAAIVLVVFNYPFMRSAGLV 195
            + G++  +   L        + +          DP LS   A +++   +  +  +  +
Sbjct: 156 NVKGAILHVMGDLLGSVGAIVAAVVIYLIGWTPIDPILSVLVAALILRSAWKLLAKSIHI 215

Query: 196 LLQTVPEGLGACDLRTAAL-RVPGVFAIHELHVWQLHRDKVVATAHV 241
           LL+  PE      +    +  VPG+ A+  +HVWQL   + +AT HV
Sbjct: 216 LLEGAPEDASPEQVEQGLMGAVPGLAAVSHVHVWQLTSGRTMATLHV 262


>UniRef50_Q5XCQ6 Cluster: Cobalt-zinc-cadmium resistance protein;
           n=12; Streptococcus|Rep: Cobalt-zinc-cadmium resistance
           protein - Streptococcus pyogenes serotype M6
          Length = 291

 Score = 43.6 bits (98), Expect = 0.007
 Identities = 34/129 (26%), Positives = 60/129 (46%), Gaps = 8/129 (6%)

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           + G L +I   L  +W+     I DP LS   A  ++    P + +   + L  VP+ + 
Sbjct: 147 ILGWLAIIILSLILKWK--PWYILDPLLSIAIASFILSKALPKLVATANIFLDGVPDSID 204

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIY--GTHEDYLKNS-ALVCDVFKR 262
            C L     ++P + ++++L+VW +      AT H      T E + K S  L+C   +R
Sbjct: 205 YCALHHELSQLPHIVSVNQLNVWSMDGIDHRATIHCCLRESTTEKHCKKSIRLIC---QR 261

Query: 263 HGIGLVTLQ 271
           + I  VT++
Sbjct: 262 YNINSVTVE 270


>UniRef50_Q5FM42 Cluster: Cation efflux protein; n=5;
           Lactobacillus|Rep: Cation efflux protein - Lactobacillus
           acidophilus
          Length = 299

 Score = 43.6 bits (98), Expect = 0.007
 Identities = 52/226 (23%), Positives = 95/226 (42%), Gaps = 30/226 (13%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           F+ S  LL D  H+L  +  +I + I+    R      +      TFG+ R E +   + 
Sbjct: 30  FSGSLALLSDAVHNLSDVGAIILSFIAHLISRRSRNNNK------TFGYERAETLAAFTN 83

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL----AGSL 150
            V+    ++ L V A+Q      H     +  +++  ++IGLL N I+ + +     G+L
Sbjct: 84  GVVLIVISVVLFVEAIQRFWEPEH----IHGGIMLVVSIIGLLANIISMLAMHRDAKGNL 139

Query: 151 FVIAAG---LTEEWEHEASRIA------------DPALSACAAIVLVVFNYPFMRSAGLV 195
            V +     L++     A  I             DP L+   ++ ++   Y     A  V
Sbjct: 140 NVRSTFIHMLSDALSSVAVVIGAVFIYFWNVTWLDPVLTILVSLFVLHEAYEITMKAANV 199

Query: 196 LLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
           L+++ P+ +    +    L  P V  IH +HVW+   D ++  AH+
Sbjct: 200 LMESNPD-IDLDKVNEIVLSFPKVTNIHHVHVWRYSDDFIMMDAHI 244


>UniRef50_A0ZGF9 Cluster: Cation efflux system protein; n=1;
           Nodularia spumigena CCY 9414|Rep: Cation efflux system
           protein - Nodularia spumigena CCY 9414
          Length = 326

 Score = 43.6 bits (98), Expect = 0.007
 Identities = 56/230 (24%), Positives = 95/230 (41%), Gaps = 35/230 (15%)

Query: 35  FTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           ++ S +L  D  H    +  L+ +L S  Y       G+      TFG  R+EV+  L  
Sbjct: 48  WSQSLSLQADAGHMFSDIAALVISLFS-TYLAQQPAKGKA-----TFGNQRVEVLAALLN 101

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL-------- 146
            +   + A  +   A+Q   H   G     P ++V  AV+GL+ N +N  LL        
Sbjct: 102 GLSLLAIATFITWEAIQRWQHP--GVILGLPMLVV--AVMGLIVNLLNISLLHPHSHNDL 157

Query: 147 --AGSLF------------VIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSA 192
              G+L             +IAA +   W+      AD A+S   A    V   P ++ +
Sbjct: 158 NLQGALLHIIADTASSVGVIIAAVMIHLWDWWW---ADVAISLVVATFTGVSALPLVQES 214

Query: 193 GLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
             + L+  P+ +   ++        GV  + +LH+W +  +KV+  A+VI
Sbjct: 215 IKIFLEYAPKSIDPVEVEKLIKSFAGVVQVEKLHIWTISSNKVMLCANVI 264


>UniRef50_Q8SQT3 Cluster: ZINC TRANSPORTER; n=1; Encephalitozoon
           cuniculi|Rep: ZINC TRANSPORTER - Encephalitozoon
           cuniculi
          Length = 334

 Score = 43.6 bits (98), Expect = 0.007
 Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 12/107 (11%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRL-SV 94
           TNS +LL D+ H L  + G I +L+S  + +      +    R TFG+ RIE++G + S+
Sbjct: 45  TNSLSLLADSLHLLVDIFGFIVSLLSLSWAK------KPSNKRMTFGYHRIEIIGSMVSI 98

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAI 141
            +++A+    LV+ +    +H    P      +  G AV+G   N I
Sbjct: 99  GLIWAAVGY-LVIESFHKYLH----PAEIDGGMFFGIAVVGFFVNCI 140


>UniRef50_Q8CNH2 Cluster: CzrB protein; n=3; Staphylococcus|Rep:
           CzrB protein - Staphylococcus epidermidis (strain ATCC
           12228)
          Length = 323

 Score = 43.2 bits (97), Expect = 0.009
 Identities = 51/229 (22%), Positives = 92/229 (40%), Gaps = 35/229 (15%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVHV 96
           NS  LL D  H L   + L   LI+F Y        +      T+G+ R E++  L   V
Sbjct: 53  NSLALLSDGFHMLSDAISLGVALIAFIYAE------KHATKSKTYGYKRFEILAALFNGV 106

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML----------- 145
                ++ +++ A++  +     PP    + +   +VIGL+ N I  +L           
Sbjct: 107 TLFIISIIIIIEAIRRFLE----PPEVQSKEMFIISVIGLMVNIIVAILMFKGGDTSHNL 162

Query: 146 ------------LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAG 193
                       L GS+  I A L   W    + IADP  S   +++++   Y   +S+ 
Sbjct: 163 NMRGAFLHVLGDLFGSVGAIVASLLI-WGFNFT-IADPIASILVSLIILKSAYGISKSSL 220

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
            +L++  P  +    +  A  +   +  +H+ HVW +  D    + H +
Sbjct: 221 NILMEGTPNDIDLNAVIKAISKDERIQNVHDCHVWTISNDMNALSCHAV 269


>UniRef50_A5G751 Cluster: Cation diffusion facilitator family
           transporter; n=1; Geobacter uraniumreducens Rf4|Rep:
           Cation diffusion facilitator family transporter -
           Geobacter uraniumreducens Rf4
          Length = 293

 Score = 43.2 bits (97), Expect = 0.009
 Identities = 57/236 (24%), Positives = 99/236 (41%), Gaps = 28/236 (11%)

Query: 35  FTNSPTLLVDTCHSL--CRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRL 92
           +TNS  ++ +  H L  C  +GL   L  +  + +D         R ++G+ R  ++G L
Sbjct: 34  WTNSIAIISNAVHDLGDCLSLGLAWYLAGYAEKESDR--------RYSYGYRRFSLLGAL 85

Query: 93  SVHVLFASFALALVVNALQLGVHSSHGPPPRYPRV-IVGSAVIGLLF------NAINYML 145
           +  ++    +L ++  A+   +   H        + +VG AV GL          +N  +
Sbjct: 86  ATALVLMVGSLLVLSEAVPRLLRPEHPNAGGMALLAVVGIAVNGLALLRVRGGRTLNARI 145

Query: 146 ----LAGSLFVIAAGLTEEWE--HEASRIADPALSACAAIVLVVFNYPF-MRSAGLVLLQ 198
               L G L   AA L+       +   + DP LS       V+FN    ++    + LQ
Sbjct: 146 VTWHLLGDLLGWAAVLSVSSVLLFKDLPLLDPILSILITSY-VLFNVSRNLKKTVQLFLQ 204

Query: 199 TVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIY---GTHEDYLK 251
            VP G+   ++    L +  V ++H  HVW L  +  V T H++     T +D LK
Sbjct: 205 AVPGGIDTGEIEKKLLAIDKVKSVHHTHVWSLDGEHNVLTTHLVVEADATRKDVLK 260


>UniRef50_A1SIT8 Cluster: Cation diffusion facilitator family
           transporter; n=4; Actinomycetales|Rep: Cation diffusion
           facilitator family transporter - Nocardioides sp.
           (strain BAA-499 / JS614)
          Length = 305

 Score = 43.2 bits (97), Expect = 0.009
 Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 6/163 (3%)

Query: 86  IEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
           +E VGR+       + A+ LVV A+ L V+ +     R         V G  F  +   +
Sbjct: 111 VEAVGRIGAEPEVQTGAM-LVVGAIGLAVNIASMLLLREGST-ESLNVKGAYFEVVADAV 168

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
             GS+ VI AGL      +     D  ++    + + V      R    VL Q VP+G+ 
Sbjct: 169 --GSVGVILAGLLVATTGQTWW--DTGVAVAIGLFVAVRAIVLGRQVLAVLGQHVPDGMQ 224

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHED 248
              +      +PG+  +H+LHVW L     VATAH++     D
Sbjct: 225 VDQVVADLEALPGIEDVHDLHVWTLTSGMNVATAHLVVAPDAD 267


>UniRef50_Q97G32 Cluster: Co/Zn/Cd efflux system component; n=1;
           Clostridium acetobutylicum|Rep: Co/Zn/Cd efflux system
           component - Clostridium acetobutylicum
          Length = 303

 Score = 42.7 bits (96), Expect = 0.012
 Identities = 16/72 (22%), Positives = 37/72 (51%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           D  L+    ++++  +Y  ++ +  +L+QT P  L   D++   L++  +  +H  H+W 
Sbjct: 186 DSVLTIFINMLILKSSYNILKESINILMQTTPVNLDMDDVKEQLLKIKEIKGVHHFHIWT 245

Query: 230 LHRDKVVATAHV 241
           L  + +V   H+
Sbjct: 246 LDENNIVLEGHI 257


>UniRef50_P72068 Cluster: Putative uncharacterized protein; n=1;
           Nannocystis exedens|Rep: Putative uncharacterized
           protein - Nannocystis exedens
          Length = 290

 Score = 42.7 bits (96), Expect = 0.012
 Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 11/122 (9%)

Query: 122 PRYPRVIVGSAVIGLLFNAINYMLLAGSL-FVIAAGLTEEWEHEASRIADPALSACAAIV 180
           P    + +  A+I +L +A+      GSL  ++AA L   W   A   AD  LS   A++
Sbjct: 147 PAATNINIRGALIHMLADAL------GSLGAIVAAVLASMW---AIHAADSILSLGIAVL 197

Query: 181 LVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAH 240
           ++   +  +R A   LL   P  L    + T    + GV  IHELH+W +    V+ TAH
Sbjct: 198 VLFSAWGVLRDATRALLDFAPTHLPQERVETELRGLAGVSEIHELHLWSVGGAPVL-TAH 256

Query: 241 VI 242
           ++
Sbjct: 257 LV 258


>UniRef50_Q29M69 Cluster: GA16530-PA; n=2; Endopterygota|Rep:
           GA16530-PA - Drosophila pseudoobscura (Fruit fly)
          Length = 716

 Score = 42.7 bits (96), Expect = 0.012
 Identities = 32/124 (25%), Positives = 62/124 (50%), Gaps = 8/124 (6%)

Query: 118 HGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACA 177
           H  PP+   + V +A+I ++ + I       S+ V  A L   +  E S + D   +   
Sbjct: 533 HVQPPK-ENINVRAAMIHVIGDMIQ------SVGVFVAALIIFFRPEWSFV-DAICTFLF 584

Query: 178 AIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVA 237
           +I++V+     +R   +VL++  P+ +   +++ A L + GV  +H L +W L  +KV  
Sbjct: 585 SIIVVLVTIRILRDVLMVLMEATPDYMDYDEVQRAFLSIEGVEHVHNLRIWALSINKVAL 644

Query: 238 TAHV 241
           +AH+
Sbjct: 645 SAHL 648



 Score = 37.9 bits (84), Expect = 0.35
 Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 15/109 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVG-RLSV 94
           +NS  +  D  H L  L G + +L +         + R    R  FGW R EV+G  +SV
Sbjct: 393 SNSLAIATDAAHLLTDLAGFLISLFALYI------SARPNTQRMNFGWYRAEVIGAMISV 446

Query: 95  HVLF--ASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAI 141
           + ++      + L +  L +G H+        P++++ ++ + +LFN I
Sbjct: 447 YFIWVITGILVWLAIQRLWVGEHNVD------PKIMLITSAVAILFNVI 489


>UniRef50_Q9LXS1 Cluster: Metal tolerance protein A2; n=17;
           rosids|Rep: Metal tolerance protein A2 - Arabidopsis
           thaliana (Mouse-ear cress)
          Length = 378

 Score = 42.7 bits (96), Expect = 0.012
 Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 1/114 (0%)

Query: 161 WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVF 220
           W     +I D   +   +++++      +R+   VL+++ P  +    L      +  V 
Sbjct: 263 WYKPEWKILDLICTLVFSVIVLGTTIGMLRNILEVLMESTPREIDPTMLEKGVCEIEEVV 322

Query: 221 AIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKR-HGIGLVTLQPE 273
           A+HELH+W +   K++   HV      +       + D  KR H I  VT+Q E
Sbjct: 323 AVHELHIWAITVGKLLLACHVKIRPEAEADMVLDKIIDYIKREHNISHVTIQIE 376


>UniRef50_UPI0000499414 Cluster: cation efflux protein; n=1;
           Entamoeba histolytica HM-1:IMSS|Rep: cation efflux
           protein - Entamoeba histolytica HM-1:IMSS
          Length = 543

 Score = 42.3 bits (95), Expect = 0.016
 Identities = 23/104 (22%), Positives = 50/104 (48%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I+DP  S C + ++     P ++++  +LLQ+VP+G     +++   ++ GV  + +L++
Sbjct: 436 ISDPICSLCLSAMIFCSVLPLLKNSASMLLQSVPKGYDDDLIKSKLNQIAGVKDVIKLNL 495

Query: 228 WQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQ 271
           W+     +VAT  +      D     + V    K      +T++
Sbjct: 496 WEFSESCLVATTVISIFPEVDSTTIRSAVITALKHEDFNDITVE 539


>UniRef50_Q8G4R7 Cluster: Probable cation efflux protein; n=4;
           Bifidobacterium|Rep: Probable cation efflux protein -
           Bifidobacterium longum
          Length = 312

 Score = 42.3 bits (95), Expect = 0.016
 Identities = 54/226 (23%), Positives = 88/226 (38%), Gaps = 26/226 (11%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           T S  LLVD  H L  +  L  + I+    R      R      T+GWAR+EV+   +  
Sbjct: 43  TGSLALLVDAGHMLTDMSVLAASTITAILMRRKPSNTR------TWGWARLEVLTAAAGA 96

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSL---FV 152
           V+     +  +V A      SS         +++ + ++GL  N I+  +LA        
Sbjct: 97  VVLLIVGIYALVEAGMRLFGSSKAEIDDIG-LLLFAGILGLAANIISIFILASQREDNMN 155

Query: 153 IAAGLTEEWEHEASRIA----------------DPALSACAAIVLVVFNYPFMRSAGLVL 196
           + A   E        +A                D    A  A++++      + +A  VL
Sbjct: 156 MKAAFLEVMNDALGSVAVVASALVMIPTGWNGFDAVAGAVIALMMIPRAIKLLHNAVKVL 215

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
           L+  P+GL    +R     VP V A+H+LH   +     +  AHV+
Sbjct: 216 LEETPDGLDLDKVREHLEDVPHVLAVHDLHASTVSTGMPILMAHVV 261


>UniRef50_A1RH69 Cluster: Cation diffusion facilitator family
           transporter; n=19; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Shewanella sp. (strain
           W3-18-1)
          Length = 305

 Score = 42.3 bits (95), Expect = 0.016
 Identities = 22/85 (25%), Positives = 41/85 (48%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I DP LS    + ++V     + +   + LQ  P+     +++   L++  + +IH LH+
Sbjct: 180 ILDPLLSIGFTLFILVNVLRNLSTTARLFLQAAPDSKLQNEIQDTLLKIDELDSIHHLHL 239

Query: 228 WQLHRDKVVATAHVIYGTHEDYLKN 252
           W L  +  V TAHV+    + +  N
Sbjct: 240 WSLDGEHHVLTAHVVTNASKAFTAN 264


>UniRef50_A0AW44 Cluster: Cation diffusion facilitator family
           transporter; n=13; Actinobacteria (class)|Rep: Cation
           diffusion facilitator family transporter - Arthrobacter
           sp. (strain FB24)
          Length = 305

 Score = 42.3 bits (95), Expect = 0.016
 Identities = 51/228 (22%), Positives = 84/228 (36%), Gaps = 29/228 (12%)

Query: 33  SHFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRL 92
           S  T S  LL D  H      GL+  LI+           +    + T+G+ R E++   
Sbjct: 37  SVLTGSLALLADAGHMFTDSTGLLIALIAASLAL------KPATAKRTWGYKRAEIIAAA 90

Query: 93  SVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSL-- 150
               L       ++V     G+     PP      ++   VIGL  NA+  ++LA     
Sbjct: 91  GQAALLLGVGGFVIVE----GIRRLIEPPEIGGGTMLWFGVIGLAGNAVGLIVLASGRNH 146

Query: 151 -FVIAAGLTEEWEHEASRIA----------------DPALSACAAIVLVVFNYPFMRSAG 193
            F + A   E        +A                D  +S    ++++      +R   
Sbjct: 147 NFNMKAAFLEVLNDALGSVAVIVAAIIIAVTGWVQADAVVSLLIGVLIIPRTLKLLRDTV 206

Query: 194 LVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV 241
            VL++  P+GL    +R   L +P V  +H+LH   +     V +AHV
Sbjct: 207 NVLMENAPQGLDMALVREHILALPHVIDVHDLHASLVASGTPVLSAHV 254


>UniRef50_A3ETR2 Cluster: Co/Zn/Cd efflux system component; n=4;
           Bacteria|Rep: Co/Zn/Cd efflux system component -
           Leptospirillum sp. Group II UBA
          Length = 335

 Score = 41.9 bits (94), Expect = 0.021
 Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 2/88 (2%)

Query: 155 AGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAAL 214
           AG    W H     A  AL   AA++L       ++ +G V L++ P+G+ +  +     
Sbjct: 194 AGALIHWTHFYRFDALAAL-VVAALMLRA-GVGLLKESGRVFLESAPKGVDSDVIGDTLA 251

Query: 215 RVPGVFAIHELHVWQLHRDKVVATAHVI 242
             PGV  +H+LHVW++       +AHV+
Sbjct: 252 ADPGVCEVHDLHVWEVTSGFTALSAHVL 279


>UniRef50_A1ZDC5 Cluster: Heavy metal efflux pump, CzcD family; n=1;
           Microscilla marina ATCC 23134|Rep: Heavy metal efflux
           pump, CzcD family - Microscilla marina ATCC 23134
          Length = 331

 Score = 41.9 bits (94), Expect = 0.021
 Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 3/109 (2%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I DP LS   A+ ++   +  +R+   V LQ VP        +   L++P V  +H++ V
Sbjct: 213 IIDPILSLLIAVYILYNAFKNLRAILNVFLQAVPPKFDLETTKEKILKIPHVIDLHDVRV 272

Query: 228 WQLHRDKVVATAHVIYGTHEDYLKNSALVCDV---FKRHGIGLVTLQPE 273
           W +   +++ + H++   +    +  AL  +V    +   IG VTL+ E
Sbjct: 273 WSMDGSEMIMSLHLVVEENLSSAQCKALKHEVKHTCQHLHIGHVTLELE 321


>UniRef50_Q9VKA3 Cluster: CG31860-PA; n=4; Diptera|Rep: CG31860-PA -
           Drosophila melanogaster (Fruit fly)
          Length = 669

 Score = 41.9 bits (94), Expect = 0.021
 Identities = 17/71 (23%), Positives = 38/71 (53%)

Query: 178 AIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVA 237
           +++++V  +  +R   +VL++  P+ +   +++   L + GV  +H L +W L  +KV  
Sbjct: 521 SVLVLVVTFKILRDVLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVAL 580

Query: 238 TAHVIYGTHED 248
           +AH+      D
Sbjct: 581 SAHLAISKDAD 591


>UniRef50_Q22541 Cluster: Putative uncharacterized protein; n=3;
           Caenorhabditis|Rep: Putative uncharacterized protein -
           Caenorhabditis elegans
          Length = 360

 Score = 41.9 bits (94), Expect = 0.021
 Identities = 18/74 (24%), Positives = 38/74 (51%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I DP  +   +++++      +R A +VLL+  P  +    + ++   + GV  +H+L +
Sbjct: 237 IIDPICTLVFSVIVLCTTIYILRDAMIVLLEGRPSNIDFAKVFSSLEDIEGVKKVHDLRI 296

Query: 228 WQLHRDKVVATAHV 241
           W L  DK+  + H+
Sbjct: 297 WSLTMDKIALSVHL 310


>UniRef50_A3XEG4 Cluster: Cation efflux system protein; n=9;
           Proteobacteria|Rep: Cation efflux system protein -
           Roseobacter sp. MED193
          Length = 305

 Score = 41.5 bits (93), Expect = 0.028
 Identities = 48/225 (21%), Positives = 88/225 (39%), Gaps = 27/225 (12%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  L+ D  H+   +  L+    + K  R      R    R TFG+ R+E+V  L  +
Sbjct: 40  SGSLALIADALHNFSDMASLVIAFAARKIAR------RPADERMTFGYGRVEIVAALINY 93

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPR-YPRVIVG--SAVIGLLFNAINYMLLAGSLFV 152
                    L+      G+     P    +  VI+G  + V+  L   + Y +  GS+ +
Sbjct: 94  TTLIVIGFYLIYEG---GMRMIDPPEVMGWTVVILGGIALVVDTLTAMLTYSMQKGSVNI 150

Query: 153 IAAGLTEEWEHEAS---------------RIADPALSACAAIVLVVFNYPFMRSAGLVLL 197
            A  L    +  AS               R  DPA++   A+ ++  ++  + +    L+
Sbjct: 151 RALFLHNLSDALASVAVIVGGTLIILYDMRWVDPAITIGIALYILYLSFTEIGAPIRTLM 210

Query: 198 QTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
              P  +   D+  A   V GV  +H +H+WQ+  +      H++
Sbjct: 211 LGSPPDIDGNDVVRAIQIVDGVVDVHHVHLWQMQENAAALDCHIV 255


>UniRef50_A0S5V1 Cluster: Putative solute carrier family 30; n=1;
           Hydra vulgaris|Rep: Putative solute carrier family 30 -
           Hydra attenuata (Hydra) (Hydra vulgaris)
          Length = 201

 Score = 41.5 bits (93), Expect = 0.028
 Identities = 27/112 (24%), Positives = 50/112 (44%), Gaps = 8/112 (7%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           + T S  L+ D+   L   V +I   ++F   +  E + R      T+GW R E++G L 
Sbjct: 12  YMTKSMALVADSFQMLSDTVSIIVGFVAFHCSKRSETSSRF-----TYGWVRAEILGALV 66

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML 145
             V  A+    +++ + +    S+       P++++    +GLL N I   L
Sbjct: 67  NSVFLAALCFTILIESFK---RSAIPERVENPKLVLIVGAVGLLVNIIGLFL 115


>UniRef50_UPI00015A66AB Cluster: solute carrier family 30 (zinc
           transporter), member 10; n=1; Danio rerio|Rep: solute
           carrier family 30 (zinc transporter), member 10 - Danio
           rerio
          Length = 393

 Score = 41.1 bits (92), Expect = 0.037
 Identities = 23/69 (33%), Positives = 36/69 (52%), Gaps = 4/69 (5%)

Query: 209 LRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIY----GTHEDYLKNSALVCDVFKRHG 264
           L  +  R+PGV ++HE HVW+L + + VA+ HV      G     +     +  +F R G
Sbjct: 297 LMESVCRLPGVSSVHEAHVWELAKGRNVASLHVKLQAPAGALWAQVSLQQQITQIFHRAG 356

Query: 265 IGLVTLQPE 273
           +  +TLQ E
Sbjct: 357 VHSLTLQLE 365


>UniRef50_Q3ZWB7 Cluster: Cation efflux family protein; n=2;
           Dehalococcoides|Rep: Cation efflux family protein -
           Dehalococcoides sp. (strain CBDB1)
          Length = 316

 Score = 41.1 bits (92), Expect = 0.037
 Identities = 26/117 (22%), Positives = 51/117 (43%), Gaps = 9/117 (7%)

Query: 163 HEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAI 222
           +  + +AD  +S    +++ +      R    V+L+  P+ +    L  +   +PGV   
Sbjct: 178 YSGNYLADIIVSVIIGLIISLGGINIFRQGLRVILEASPKDINISQLAASVKNIPGVKDF 237

Query: 223 HELHVWQLHRDKVVATAHVIYG----THEDYLKNSALVCDVFKRHGIGL--VTLQPE 273
           H +H+W +  +    +AHV+      +  DY++      +   R G  L  +TLQ E
Sbjct: 238 HHIHIWSISPEIHALSAHVLIDDCPVSQADYIRQQ---IETSLREGFALNHITLQME 291


>UniRef50_Q3VS68 Cluster: Cation efflux protein; n=2;
           Chlorobiaceae|Rep: Cation efflux protein -
           Prosthecochloris aestuarii DSM 271
          Length = 319

 Score = 41.1 bits (92), Expect = 0.037
 Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 2/97 (2%)

Query: 146 LAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLG 205
           LAGS+ V+A  +        +   D  +S   AI++V      +R A  VL+++VP  L 
Sbjct: 182 LAGSVGVVAGSILISLTRITT--IDSIISFIIAILIVQSALKIIREAVDVLMESVPPELD 239

Query: 206 ACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
             ++  A L    V  +H+LHVW L       + H++
Sbjct: 240 IQEIEEALLNFRHVEGLHDLHVWALTSGVNALSCHLL 276


>UniRef50_A5W938 Cluster: Cation diffusion facilitator family
           transporter; n=1; Pseudomonas putida F1|Rep: Cation
           diffusion facilitator family transporter - Pseudomonas
           putida F1
          Length = 312

 Score = 41.1 bits (92), Expect = 0.037
 Identities = 18/65 (27%), Positives = 35/65 (53%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DPA+    A+++ ++    +R  G VLL    +     ++R    ++P   +I +LHVW+
Sbjct: 209 DPAMGLVGALLVALWARGLLRDTGRVLLDAEMDAPVVAEIREVVAQLPAPASITDLHVWR 268

Query: 230 LHRDK 234
           + RD+
Sbjct: 269 VGRDQ 273


>UniRef50_O14863 Cluster: Zinc transporter 4; n=33;
           Euteleostomi|Rep: Zinc transporter 4 - Homo sapiens
           (Human)
          Length = 429

 Score = 41.1 bits (92), Expect = 0.037
 Identities = 16/75 (21%), Positives = 40/75 (53%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           +IADP  +   ++++    +  +    +++L+ VP  L    ++ A +++  V+++ +L+
Sbjct: 302 KIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDLN 361

Query: 227 VWQLHRDKVVATAHV 241
           +W L   K  A  H+
Sbjct: 362 IWSLTSGKSTAIVHI 376


>UniRef50_Q83MV9 Cluster: Cation efflux protein; n=2; Tropheryma
           whipplei|Rep: Cation efflux protein - Tropheryma
           whipplei (strain Twist) (Whipple's bacillus)
          Length = 312

 Score = 40.7 bits (91), Expect = 0.049
 Identities = 48/195 (24%), Positives = 98/195 (50%), Gaps = 25/195 (12%)

Query: 92  LSVHVLFASFALALVVN-ALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAI-NYMLLAGS 149
           +S  V+F +    L+VN +  L +HS+     +   + + +A + +L +AI +  ++  +
Sbjct: 126 ISGWVIFVTGIAGLLVNLSAVLVLHSA-----KQKGINLRAAYMEVLSDAIASVSVMLSA 180

Query: 150 LFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGL-VLLQTVPEGLGACD 208
           + +I  GLT         I D +++A A ++ + +    +    + +LLQ  P  +   +
Sbjct: 181 ILIILTGLT---------IID-SIAAIAIVLFICYRAAKLGKEVIRILLQASPVDIQ--E 228

Query: 209 LRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV---CDVFKRHGI 265
           + ++ L + GV ++  LH W L  +K +ATA+++   H+   +N  LV     +++++GI
Sbjct: 229 VESSLLGIDGVISVDHLHAWTLSDEKHIATANIL--IHKQTDQNKVLVEAERILYEQYGI 286

Query: 266 GLVTLQPEFMLTSSR 280
              TLQ   M   SR
Sbjct: 287 LHTTLQISPMRLESR 301


>UniRef50_Q4T2L9 Cluster: Chromosome undetermined SCAF10234, whole
           genome shotgun sequence; n=2; Tetraodontidae|Rep:
           Chromosome undetermined SCAF10234, whole genome shotgun
           sequence - Tetraodon nigroviridis (Green puffer)
          Length = 401

 Score = 40.3 bits (90), Expect = 0.065
 Identities = 26/108 (24%), Positives = 47/108 (43%), Gaps = 2/108 (1%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGAC--DLRTAALRVPGVFAIHEL 225
           IADP  S   A+++ V   P ++ +  +L+Q  P  L     D       + GV+++ E 
Sbjct: 290 IADPICSMLIALLIAVSVIPLLKESIGILMQRTPPSLDHALPDCYQRVQHLQGVYSLQEP 349

Query: 226 HVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQPE 273
           H W L  D  + T  ++     D     +    +F + G+  + +Q E
Sbjct: 350 HFWTLCSDVYIGTVKLLVAPDADSRWILSQTHHIFTQAGVRQLYVQME 397


>UniRef50_Q6ML10 Cluster: Cation-efflux system membrane protein;
           n=1; Bdellovibrio bacteriovorus|Rep: Cation-efflux
           system membrane protein - Bdellovibrio bacteriovorus
          Length = 310

 Score = 40.3 bits (90), Expect = 0.065
 Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 4/76 (5%)

Query: 171 PALSACAAIVL---VVFNYPF-MRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           P L A  AIVL   +++N    +R A  V L   P  +   D+  A L V  V  +H  H
Sbjct: 189 PQLDAGMAIVLAAWILYNVVRNLREALKVFLMASPSHIQVLDVEKAILEVEHVVGVHHAH 248

Query: 227 VWQLHRDKVVATAHVI 242
           +W L  +  + T HV+
Sbjct: 249 LWSLDGENHIFTGHVV 264


>UniRef50_A6LME7 Cluster: Cation diffusion facilitator family
           transporter; n=1; Thermosipho melanesiensis BI429|Rep:
           Cation diffusion facilitator family transporter -
           Thermosipho melanesiensis BI429
          Length = 294

 Score = 40.3 bits (90), Expect = 0.065
 Identities = 24/108 (22%), Positives = 51/108 (47%), Gaps = 5/108 (4%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I DP ++   +  +++ +   ++ +  V++Q +P+G+    ++        V  +H +HV
Sbjct: 177 ILDPIITFVISGYIIIESIKILKESIRVVMQGIPKGVDLDKVKKIIQNFSFVKDVHHIHV 236

Query: 228 WQLHRDKVVATAHVIYG--THEDYLKNSALVCDVFKRHGIGLVTLQPE 273
           W L   ++    HV      ++DYL+    + +  K HG    T+Q E
Sbjct: 237 WSLDGIELYLEMHVTVDGKDYDDYLRR---IKETLKEHGFRHSTIQLE 281


>UniRef50_A0BG38 Cluster: Chromosome undetermined scaffold_105,
           whole genome shotgun sequence; n=1; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_105,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 603

 Score = 40.3 bits (90), Expect = 0.065
 Identities = 31/144 (21%), Positives = 67/144 (46%), Gaps = 6/144 (4%)

Query: 133 VIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEAS--RIADPALSACAAIVLVVFNYPFMR 190
           VIG +  +I  ++ A  +++      E  +   +  + ADP  +   +I+++   +   +
Sbjct: 444 VIGDILQSIGVLIAAILIYIFGQKKDENNQIVFTYWQYADPFCTYLFSILVLFTTFGVAK 503

Query: 191 SAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDY- 249
               VL++  P+ L   +       +  V  +H+LH+W L   K   +AH++   + +Y 
Sbjct: 504 ECLRVLMEGTPQNLIIEEFNEKLKAIHRVKEVHDLHIWSLSVGKPAMSAHIVCIENPEYV 563

Query: 250 LKNSALVCDVFKRHGIGLVTLQPE 273
           L+ +  +C   ++ GI   T+Q E
Sbjct: 564 LRKATKLC---RQFGIYHSTIQIE 584


>UniRef50_UPI00005852CD Cluster: PREDICTED: similar to solute
           carrier family 30 (zinc transporter), member 6; n=2;
           Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
           solute carrier family 30 (zinc transporter), member 6 -
           Strongylocentrotus purpuratus
          Length = 570

 Score = 39.9 bits (89), Expect = 0.086
 Identities = 37/142 (26%), Positives = 65/142 (45%), Gaps = 10/142 (7%)

Query: 136 LLFNAINYMLLAGSLFVIAAGLTEEW-EHEASRIADPALSACAAIVLVVFNYPFMRSAGL 194
           LL   +N  +L G   +++  +T+   +     +ADP  + C A++ V   +P    +G 
Sbjct: 265 LLLPRVNPFILIGLCSMLSLCVTDFLVDMNNFHMADPLAALCIAMMTVGTMFPMSVYSGT 324

Query: 195 VLLQTVPEG-LGACD--LRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLK 251
           +LLQT P   LG  D  LR A+  + GV      H W L   ++  + +V      D   
Sbjct: 325 ILLQTTPAHILGQLDKSLREAS-TLDGVLEFRNEHFWTLSFGQLAGSLNVRVRRDAD--- 380

Query: 252 NSALVCDVFKR--HGIGLVTLQ 271
              ++  VF +  H + ++T+Q
Sbjct: 381 EQMVLAHVFNKLSHLVNILTIQ 402


>UniRef50_Q8T0G1 Cluster: LD05335p; n=1; Drosophila
           melanogaster|Rep: LD05335p - Drosophila melanogaster
           (Fruit fly)
          Length = 498

 Score = 39.9 bits (89), Expect = 0.086
 Identities = 19/83 (22%), Positives = 40/83 (48%)

Query: 166 SRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHEL 225
           ++ ADP  +   +I++++      R +  +++  VP+ L    L      + GV ++H L
Sbjct: 385 AKYADPLCTLIFSIIVIMTTLRLFRESLGIIVNAVPQNLNMRTLHLELGSIEGVRSLHHL 444

Query: 226 HVWQLHRDKVVATAHVIYGTHED 248
           +VWQ    + V   H++  +  D
Sbjct: 445 NVWQQTSQQRVLMVHLVTDSRAD 467


>UniRef50_Q45EL5 Cluster: Similar to transporter of divalent cations
           protein 1, isoform b; n=3; Caenorhabditis|Rep: Similar
           to transporter of divalent cations protein 1, isoform b
           - Caenorhabditis elegans
          Length = 446

 Score = 39.9 bits (89), Expect = 0.086
 Identities = 46/181 (25%), Positives = 69/181 (38%), Gaps = 8/181 (4%)

Query: 68  DEGTGREGRLRNTFGWARIEVVGRLSVHVLFASFALAL--VVNALQLGVHSS---HGPPP 122
           D     E  +    GW         SV +L +++AL      + LQ    SS   H    
Sbjct: 138 DASAAHEHEVEEIGGWPYFVGSAASSVALLLSAYALKNQPFQHVLQSATASSLQEHAADL 197

Query: 123 RYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLV 182
            +    V   +  LL   IN M+L          L E ++H+ +  ADP      ++ + 
Sbjct: 198 SHAVCWVIPGLSRLLLPRINSMVLLALTTTGLNLLCEHFKHDFAW-ADPVCCLLLSVAVF 256

Query: 183 VFNYPFMRSAGLVLLQTVPEGL-GACD-LRTAALRVPGVFAIHELHVWQLHRDKVVATAH 240
              YP     G++LLQT P  L    D   + A  + GV  +     WQL  + +V T  
Sbjct: 257 STMYPLSTYTGMILLQTTPPHLINQIDRCISEASHIDGVLELKSGRFWQLDFNSLVGTVD 316

Query: 241 V 241
           V
Sbjct: 317 V 317


>UniRef50_Q1ZSN3 Cluster: Cation diffusion facilitator family
           transporter; n=1; Vibrio angustum S14|Rep: Cation
           diffusion facilitator family transporter - Vibrio
           angustum S14
          Length = 301

 Score = 39.5 bits (88), Expect = 0.11
 Identities = 17/78 (21%), Positives = 35/78 (44%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           D A S    +V+++  +  ++ +    L  VP  +    L+     +P V   H+LHVW 
Sbjct: 180 DSATSLAIVVVILIGTWGLLKDSINYSLDAVPSNVDMVGLKAYLAALPNVATFHDLHVWP 239

Query: 230 LHRDKVVATAHVIYGTHE 247
           +   +   T H++   ++
Sbjct: 240 MSTTENAMTVHLVVDEYD 257


>UniRef50_Q0ICB8 Cluster: Cation efflux system protein; n=2;
           Synechococcus|Rep: Cation efflux system protein -
           Synechococcus sp. (strain CC9311)
          Length = 289

 Score = 39.5 bits (88), Expect = 0.11
 Identities = 15/71 (21%), Positives = 35/71 (49%)

Query: 197 LQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALV 256
           +  +P+ +    +++    + GV +IH LH+W L   +V  TAH++    +    ++ + 
Sbjct: 203 MDAIPDYIDINKVKSTLQNIKGVESIHHLHIWPLSTSRVALTAHIVRSLSQSEADHNLIS 262

Query: 257 CDVFKRHGIGL 267
               K + +G+
Sbjct: 263 TASSKMNSLGI 273


>UniRef50_Q02XW1 Cluster: Co/Zn/Cd efflux system component; n=3;
           Lactococcus lactis|Rep: Co/Zn/Cd efflux system component
           - Lactococcus lactis subsp. cremoris (strain SK11)
          Length = 305

 Score = 39.5 bits (88), Expect = 0.11
 Identities = 20/80 (25%), Positives = 41/80 (51%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP LS   A+ ++    P       +LL++VPE +    L  A  ++P V ++ +L +W 
Sbjct: 188 DPLLSILIALFILSKAIPKFWGTLRILLESVPEDIDYKKLLIALEKLPEVRSVTQLIIWS 247

Query: 230 LHRDKVVATAHVIYGTHEDY 249
           +  ++  A  H++   ++D+
Sbjct: 248 IDGEQNAAMIHIVIPENQDF 267


>UniRef50_Q5ZRY2 Cluster: Cation efflux system protein; n=4;
           Legionella pneumophila|Rep: Cation efflux system protein
           - Legionella pneumophila subsp. pneumophila (strain
           Philadelphia 1 /ATCC 33152 / DSM 7513)
          Length = 307

 Score = 39.1 bits (87), Expect = 0.15
 Identities = 16/72 (22%), Positives = 35/72 (48%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +    A+V++   +     +  +++  VP  +    +    L +PGV +IH+LH+W 
Sbjct: 186 DPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHDLHIWA 245

Query: 230 LHRDKVVATAHV 241
           +   +   + H+
Sbjct: 246 ISTKENALSVHL 257


>UniRef50_Q9ALR5 Cluster: CztD; n=1; Pseudomonas fluorescens|Rep:
           CztD - Pseudomonas fluorescens
          Length = 85

 Score = 39.1 bits (87), Expect = 0.15
 Identities = 27/67 (40%), Positives = 37/67 (55%), Gaps = 8/67 (11%)

Query: 212 AALRVPGVFAIHELHVWQLHRDKVVATAHVI----YGTHEDYLKNSALVCDVF-KRHGIG 266
           A  +VPGV  IH+LH+W L   K V + H++     GT +  L   ALV +V  ++  I 
Sbjct: 8   AIRKVPGVKDIHDLHIWALTSGKNVLSTHLVADSTLGTEQQIL---ALVTEVLHEQFDIS 64

Query: 267 LVTLQPE 273
            VTLQ E
Sbjct: 65  HVTLQVE 71


>UniRef50_O85143 Cluster: Transport protein; n=35; Bacteria|Rep:
           Transport protein - Staphylococcus aureus
          Length = 326

 Score = 39.1 bits (87), Expect = 0.15
 Identities = 16/75 (21%), Positives = 38/75 (50%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           IADP  S   +++++   +   +S+  +L++  P  +   ++ T   +   + ++H+ HV
Sbjct: 187 IADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTITKDSRIQSVHDCHV 246

Query: 228 WQLHRDKVVATAHVI 242
           W +  D    + HV+
Sbjct: 247 WTISNDMNALSCHVV 261


>UniRef50_A0LXC1 Cluster: CDF family cation efflux protein; n=3;
           Bacteria|Rep: CDF family cation efflux protein -
           Gramella forsetii (strain KT0803)
          Length = 295

 Score = 39.1 bits (87), Expect = 0.15
 Identities = 18/72 (25%), Positives = 36/72 (50%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DPALS    + ++      ++    V LQ VP+ +   ++++    +  V ++H  H+W 
Sbjct: 176 DPALSLLITLYILYNVIIRLKDTLFVFLQGVPKDIDLDEIKSKIREIENVSSLHHTHLWS 235

Query: 230 LHRDKVVATAHV 241
           L  +  V T+H+
Sbjct: 236 LEGEHHVFTSHI 247


>UniRef50_Q8WQB6 Cluster: Putative uncharacterized protein; n=2;
           Caenorhabditis|Rep: Putative uncharacterized protein -
           Caenorhabditis elegans
          Length = 746

 Score = 38.7 bits (86), Expect = 0.20
 Identities = 35/126 (27%), Positives = 53/126 (42%), Gaps = 2/126 (1%)

Query: 148 GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGAC 207
           GS+FVI + L  +W        DP  S   +++++   YP + S+   LLQ VPE     
Sbjct: 573 GSVFVIISTLLIQWFGWVW--VDPLCSLILSLLIIGSVYPLLVSSISTLLQDVPEEEEFE 630

Query: 208 DLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGL 267
                 L +  V +    H+WQ   D  VA+ HV      +       V ++ K  G   
Sbjct: 631 YHINEILEIEHVESYSNAHMWQHKSDINVASVHVQVKEEANAQMIRHRVSNILKSTGATH 690

Query: 268 VTLQPE 273
            T+Q E
Sbjct: 691 STVQVE 696


>UniRef50_Q6DBM8 Cluster: Metal tolerance protein B; n=1;
           Arabidopsis thaliana|Rep: Metal tolerance protein B -
           Arabidopsis thaliana (Mouse-ear cress)
          Length = 375

 Score = 38.7 bits (86), Expect = 0.20
 Identities = 14/56 (25%), Positives = 32/56 (57%)

Query: 187 PFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
           P +++   +L++ VP  +    L     R+ GV  +++LHVW++   ++V + H++
Sbjct: 286 PILKNIFGILMERVPRDMDIEKLERGLKRIDGVKIVYDLHVWEITVGRIVLSCHIL 341


>UniRef50_UPI0000DAE7E5 Cluster: hypothetical protein
           Rgryl_01001288; n=1; Rickettsiella grylli|Rep:
           hypothetical protein Rgryl_01001288 - Rickettsiella
           grylli
          Length = 374

 Score = 38.3 bits (85), Expect = 0.26
 Identities = 37/143 (25%), Positives = 66/143 (46%), Gaps = 16/143 (11%)

Query: 37  NSPTLLVDTCHSLCRLVGLITTLISFKY--ERADEGTGREGRLRNTFGWARIEVVGRLSV 94
           +S  LL D  HSL  L+  +  +I+ K+  + ADE         + +G  RIE    + +
Sbjct: 35  HSHGLLADGVHSLSDLMVDLLVIIASKFGNKAADEN--------HPYGHGRIETAATVLL 86

Query: 95  HVLFASFALALVVNALQLGVHSSHGPPPRYP-RVIVGSAVIGLLFNAINYMLLAGSLFVI 153
            +L A  ALA++VNA+   +H  H      P ++++  A+  +L N + Y         I
Sbjct: 87  AILLALAALAIIVNAVTT-IHRIH--VKEIPSQIVLWIALSSILLNELIYFWTKHIAIQI 143

Query: 154 AAGL--TEEWEHEASRIADPALS 174
            + L  +  W H +   +  A++
Sbjct: 144 KSNLLMSNAWHHRSDSFSSMAVA 166


>UniRef50_UPI0000DD7936 Cluster: PREDICTED: similar to solute
           carrier family 30 (zinc transporter), member 10 isoform
           a; n=5; Mammalia|Rep: PREDICTED: similar to solute
           carrier family 30 (zinc transporter), member 10 isoform
           a - Homo sapiens
          Length = 152

 Score = 37.9 bits (84), Expect = 0.35
 Identities = 17/77 (22%), Positives = 40/77 (51%), Gaps = 3/77 (3%)

Query: 78  RNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLL 137
           ++T+G+ R +VVG     +   +   +++V A++  ++         P +++ + +IGL 
Sbjct: 68  KSTYGFLRADVVGAFGNTIFAVALMFSILVEAIKRYINPQK---TEEPILVLSAGIIGLF 124

Query: 138 FNAINYMLLAGSLFVIA 154
           FN +NY++     +  A
Sbjct: 125 FNVLNYVIFLDCCYCAA 141


>UniRef50_Q6QSW0 Cluster: Cation efflux facilitator; n=1;
           Enterococcus faecium|Rep: Cation efflux facilitator -
           Enterococcus faecium (Streptococcus faecium)
          Length = 307

 Score = 37.9 bits (84), Expect = 0.35
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%)

Query: 164 EASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIH 223
           EA R+ DP LS   A+ ++    P   S   +LL   PE +   +L ++   +P V A+ 
Sbjct: 182 EAYRL-DPILSILIALYILYKTVPEFLSTMKILLNGSPENVNVENLASSINNIPAVKALS 240

Query: 224 ELHVWQL 230
             H+W L
Sbjct: 241 HFHIWSL 247


>UniRef50_A3VSL3 Cluster: Cation efflux protein; n=1; Parvularcula
           bermudensis HTCC2503|Rep: Cation efflux protein -
           Parvularcula bermudensis HTCC2503
          Length = 339

 Score = 37.9 bits (84), Expect = 0.35
 Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 1/57 (1%)

Query: 186 YPFMRSAGLVLLQTVPEGLGACDLRTAALR-VPGVFAIHELHVWQLHRDKVVATAHV 241
           Y  ++  G+VLL+  P+ +   DLR    R V GV  +H + +W L      AT HV
Sbjct: 209 YALVKETGVVLLEGAPQEIDPTDLRDVIRRDVRGVTDVHNVRLWMLTPGANQATMHV 265


>UniRef50_Q5V738 Cluster: Cation efflux system protein; n=1;
           Haloarcula marismortui|Rep: Cation efflux system protein
           - Haloarcula marismortui (Halobacterium marismortui)
          Length = 311

 Score = 37.9 bits (84), Expect = 0.35
 Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 4/106 (3%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           IADP  +    ++++      +R +  +LL+  P  + + +LR     + GV  I +LHV
Sbjct: 189 IADPVAAVLIGLLVLASAGNVLRESTSILLERSP--VSSEELRDELTTLDGVDQIEDLHV 246

Query: 228 WQLHRDKVVATAHV--IYGTHEDYLKNSALVCDVFKRHGIGLVTLQ 271
           WQ+     VAT  +     T E+  +  + V D     GI   T++
Sbjct: 247 WQVCSQLTVATVRLTDTSTTLEEQRRIQSRVHDYLTNRGIDHATVE 292


>UniRef50_Q5LTM6 Cluster: Cation efflux system protein; n=13;
           Alphaproteobacteria|Rep: Cation efflux system protein -
           Silicibacter pomeroyi
          Length = 320

 Score = 37.5 bits (83), Expect = 0.46
 Identities = 65/262 (24%), Positives = 102/262 (38%), Gaps = 36/262 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  L+ D  H+    V LI   I+F   R      R    R ++G+ R EV+  L  +
Sbjct: 56  SGSLALIADALHNFSDAVALI---IAFGARRIAR---RPADARMSYGYGRAEVIAALINY 109

Query: 96  VLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYML---------- 145
                 AL LV      G+     P P    ++V  A + L+ + +   L          
Sbjct: 110 TTLIVLALYLVYE----GIMRFLDPQPIDGWLVVWIAALALVIDLVTAALTWSMAKTSMN 165

Query: 146 --------LA---GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGL 194
                   LA   GS+ VI AG    W        DP ++   A  ++   +  + +A  
Sbjct: 166 IRAAFLHNLADALGSVAVIVAGSAVIWF--GWTWVDPLVTLMIAAYILWHVWVEIGAAIG 223

Query: 195 VLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIY--GTHEDYLKN 252
           VL+   P G     +      V GV ++H LH+W L  +    +AH++   G        
Sbjct: 224 VLMLGTPPGYEPETVAREIEAVEGVQSLHLLHLWSLQENAAALSAHLVIEPGAWGQADAI 283

Query: 253 SALVCDVFK-RHGIGLVTLQPE 273
            A V  + + +HGI  VTL+ E
Sbjct: 284 KARVKTLLEDKHGIAHVTLETE 305


>UniRef50_A7HC19 Cluster: Cation diffusion facilitator family
           transporter; n=4; Cystobacterineae|Rep: Cation diffusion
           facilitator family transporter - Anaeromyxobacter sp.
           Fw109-5
          Length = 342

 Score = 37.5 bits (83), Expect = 0.46
 Identities = 24/99 (24%), Positives = 45/99 (45%), Gaps = 3/99 (3%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           R  DP LS   A +++      +     +L++ VP  L    +        GV A+H+LH
Sbjct: 220 RWLDPVLSLAIAALILWGALRLIFEITDILMEGVPRHLDVAAVTRQMESAHGVSAVHDLH 279

Query: 227 VWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGI 265
           +W +       +AH++    E   +N  ++ +V  +HG+
Sbjct: 280 IWTISSGMYALSAHLVVHA-ESIGRNDDILNEV--KHGL 315


>UniRef50_A3PRE9 Cluster: Cation diffusion facilitator family
           transporter; n=3; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Rhodobacter sphaeroides
           (strain ATCC 17029 / ATH 2.4.9)
          Length = 320

 Score = 37.5 bits (83), Expect = 0.46
 Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 4/71 (5%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +    A+V+  ++   +RSAG VL+  +PE         AAL   G   I +LHVWQ
Sbjct: 219 DPLIGLLGALVIARWSLGLLRSAGGVLVDFIPEEEELPAEIRAALET-GCDRITDLHVWQ 277

Query: 230 L---HRDKVVA 237
           L   H   +VA
Sbjct: 278 LGPGHHGAIVA 288


>UniRef50_Q6A8D8 Cluster: Cation-efflux transport protein; n=2;
           Actinomycetales|Rep: Cation-efflux transport protein -
           Propionibacterium acnes
          Length = 303

 Score = 37.1 bits (82), Expect = 0.61
 Identities = 25/100 (25%), Positives = 47/100 (47%), Gaps = 8/100 (8%)

Query: 146 LAGSLFVIAAGL---TEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPE 202
           L G +  + AGL   T  W   A  IA  +L  C  ++   ++   +   G +L++  P 
Sbjct: 161 LFGFIGTLVAGLVIVTTGWTR-ADAIA--SLIICGLMLRAAWS--LLSQTGRILMEVAPA 215

Query: 203 GLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
            L   ++R   + +  V ++H+LH W +  D    +AH++
Sbjct: 216 SLDLDEVRHHLMDLDHVRSVHDLHAWTVSSDLPALSAHIV 255


>UniRef50_A1W9S8 Cluster: Cation diffusion facilitator family
           transporter; n=31; cellular organisms|Rep: Cation
           diffusion facilitator family transporter - Acidovorax
           sp. (strain JS42)
          Length = 333

 Score = 37.1 bits (82), Expect = 0.61
 Identities = 30/103 (29%), Positives = 45/103 (43%), Gaps = 4/103 (3%)

Query: 169 ADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVW 228
           ADPA+    A+V+  +++  +R AG VLL    EG          L   G   + +LHVW
Sbjct: 231 ADPAMGVVGALVIARWSWGLIRDAGGVLLDAPAEGPQVRQEIEDILAATG-DTLKDLHVW 289

Query: 229 QLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKRHGIGLVTLQ 271
           Q+      A   V   T +      AL+  V   H +  VT++
Sbjct: 290 QVGPGHFAAIISVASATPQPAQHYKALLLPV---HELSHVTVE 329


>UniRef50_UPI0000D56740 Cluster: PREDICTED: similar to T18D3.3; n=1;
           Tribolium castaneum|Rep: PREDICTED: similar to T18D3.3 -
           Tribolium castaneum
          Length = 337

 Score = 36.7 bits (81), Expect = 0.80
 Identities = 20/80 (25%), Positives = 38/80 (47%), Gaps = 2/80 (2%)

Query: 165 ASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHE 224
           ++++ADP  +   + V++       + +  +LL+  P+  G  DL    L +  V  +H 
Sbjct: 251 SAKVADPICTLIFSAVVIFTTAKVAKDSIWLLLEGSPKHSG--DLAFELLNISNVRHLHN 308

Query: 225 LHVWQLHRDKVVATAHVIYG 244
           LH+W L   K   + H+  G
Sbjct: 309 LHIWALSPGKDAVSVHLCVG 328


>UniRef50_Q01S49 Cluster: Putative uncharacterized protein; n=1;
           Solibacter usitatus Ellin6076|Rep: Putative
           uncharacterized protein - Solibacter usitatus (strain
           Ellin6076)
          Length = 809

 Score = 36.7 bits (81), Expect = 0.80
 Identities = 32/105 (30%), Positives = 48/105 (45%), Gaps = 5/105 (4%)

Query: 61  SFKYERADEGTGREGRLRNTFGWARIEVVGRL---SVHVLFASFALALVVNALQLGVHSS 117
           + ++ RA  G  RE  +R   G +R  V+ +L   SV +  A   L L++    + +  S
Sbjct: 292 NLQFARAT-GRLREVAVRTALGASRWRVIAQLVTESVLLSLAGAVLGLLIARWGVSMMKS 350

Query: 118 HGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWE 162
            G PP   R I+G   I L F  + + L A     I AGL   W+
Sbjct: 351 -GMPPEIERYILGWKDISLDFRTLAFALGAAVASGILAGLAPAWQ 394


>UniRef50_Q4DHZ0 Cluster: Zinc transporter, putative; n=2;
           Trypanosoma cruzi|Rep: Zinc transporter, putative -
           Trypanosoma cruzi
          Length = 416

 Score = 36.3 bits (80), Expect = 1.1
 Identities = 28/118 (23%), Positives = 48/118 (40%), Gaps = 3/118 (2%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           +ADP  S    ++ +       +    VLL+ VP  +    +R   L V  V  I +LH+
Sbjct: 297 LADPFFSFLFGLITIYTTRDLFKEVVSVLLEEVPASVSYDSVRDVLLGVENVERIDDLHM 356

Query: 228 WQLHRDKVVATAHVIYGTHEDYLKNSALVCDV---FKRHGIGLVTLQPEFMLTSSRGT 282
           W +  +  + +AH+         +   LV +     KR G+   T+Q   +     GT
Sbjct: 357 WSVGPNFHLLSAHLTVAGCSTIREAKELVEEAAGRCKRLGLAHATIQLNHVSRIENGT 414


>UniRef50_Q2U893 Cluster: Amino acid transporters; n=1; Aspergillus
           oryzae|Rep: Amino acid transporters - Aspergillus oryzae
          Length = 479

 Score = 36.3 bits (80), Expect = 1.1
 Identities = 37/133 (27%), Positives = 58/133 (43%), Gaps = 7/133 (5%)

Query: 84  ARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN---A 140
           +R   VG    + L A+F + + V  + +  +SSH  P  +  V VG  +  L+ N    
Sbjct: 104 SRPHPVGPQKYNRLRATFLILMAVVEVSIHQYSSHSKPWHHFLVYVGVCINALVVNLPKV 163

Query: 141 INYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTV 200
           +++ L A  +F+  A L           A+P  SA A  V V  N  +  +A +  L  +
Sbjct: 164 MDWSLSASLVFINGATLFVLITLPVR--ANPKQSATAVFVSVANNSGWGSAAVVFFLNVL 221

Query: 201 P--EGLGACDLRT 211
           P    LG CD  T
Sbjct: 222 PGLASLGTCDAAT 234


>UniRef50_UPI0000E4799B Cluster: PREDICTED: similar to zinc
           transporter ZnT-2; n=2; Strongylocentrotus
           purpuratus|Rep: PREDICTED: similar to zinc transporter
           ZnT-2 - Strongylocentrotus purpuratus
          Length = 379

 Score = 35.9 bits (79), Expect = 1.4
 Identities = 17/82 (20%), Positives = 36/82 (43%)

Query: 167 RIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELH 226
           +I DP L+     +++   +   + +  +L+   P G+   + +   + + GV  +H L 
Sbjct: 250 KILDPILTIIFGFIVLGTLFGLFKESIHILMAGKPTGVDYDEAKRRLVEIDGVEGVHSLR 309

Query: 227 VWQLHRDKVVATAHVIYGTHED 248
           +W L  D  +   H+I     D
Sbjct: 310 IWSLTSDVPLVCVHLILARFYD 331


>UniRef50_A1JTE6 Cluster: Putative oxidoreductase; n=1; Yersinia
           enterocolitica subsp. enterocolitica 8081|Rep: Putative
           oxidoreductase - Yersinia enterocolitica serotype O:8 /
           biotype 1B (strain 8081)
          Length = 338

 Score = 35.9 bits (79), Expect = 1.4
 Identities = 23/71 (32%), Positives = 35/71 (49%)

Query: 192 AGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLK 251
           A +V+ Q + + L    L  AAL V     IH  H +    D VV T H+   THE  +K
Sbjct: 256 AAVVVEQHLVDALRHKQLAGAALDVYAHEPIHANHPFIHEFDNVVITPHIAGATHETLVK 315

Query: 252 NSALVCDVFKR 262
           ++A++    +R
Sbjct: 316 HTAMIAQDIER 326


>UniRef50_Q54F34 Cluster: Putative uncharacterized protein; n=1;
           Dictyostelium discoideum AX4|Rep: Putative
           uncharacterized protein - Dictyostelium discoideum AX4
          Length = 770

 Score = 35.9 bits (79), Expect = 1.4
 Identities = 31/118 (26%), Positives = 52/118 (44%), Gaps = 8/118 (6%)

Query: 148 GSLFVIAAGLTEE-WEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGA 206
           GS+ VI + L  + W +    +ADP  S   +I++ +   P + +    LLQ  PE + +
Sbjct: 594 GSVGVIVSSLIIQIWGYT---LADPICSLLISILIFLSVLPLIANTAKTLLQCTPEPIQS 650

Query: 207 C--DLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKR 262
               +    L + GV  I   H W  + D  +AT  +    +E    NS L  +  K+
Sbjct: 651 SLYQINQFILSIDGVHNIISYHFWSHYDDMNIATLKI--QLNETASSNSTLDTERIKK 706


>UniRef50_Q6D7E5 Cluster: Zinc transporter zitB; n=40;
           Enterobacteriaceae|Rep: Zinc transporter zitB - Erwinia
           carotovora subsp. atroseptica (Pectobacterium
           atrosepticum)
          Length = 320

 Score = 35.9 bits (79), Expect = 1.4
 Identities = 61/262 (23%), Positives = 106/262 (40%), Gaps = 35/262 (13%)

Query: 36  TNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLSVH 95
           + S  LL D  H L     L   L++ ++ +      R+   R+TFG+ R+  +    V+
Sbjct: 37  SGSLALLADAGHMLTDAAALFVALVAVRFAQ------RKPNARHTFGYLRLTTLAAF-VN 89

Query: 96  VLFASFALALVV-NALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLL-------- 146
            L      A +   A+Q        P    P ++V  A+ GLL N + + LL        
Sbjct: 90  ALTLILITAFIFWEAIQRFYDPQ--PVAGVPMLLV--AIAGLLANIVAFWLLHHGSEEKN 145

Query: 147 ----AGSLFVIAAGLTEEWEHEASRIA--------DPALSACAAIVLVVFNYPFMRSAGL 194
               A +L V+   L       A+ I         DP LS   + +++   +  ++ +  
Sbjct: 146 INVRAAALHVLGDLLGSVGAIAAAIIILYTNWTPIDPILSILVSCLVLRSAWALLKESIH 205

Query: 195 VLLQTVPEGLGACDL-RTAALRVPGVFAIHELHVWQLHRDKVVATAHV-IYGTHEDYLKN 252
            LL+  P  L    L +   L +P V  IH +H+WQ+  +K + T H  +   H+     
Sbjct: 206 ELLEGTPSQLSVEALQKDVTLNIPEVRNIHHVHLWQV-GEKPMMTLHAQVVPPHDHDALL 264

Query: 253 SALVCDVFKRHGIGLVTLQPEF 274
             +   + K + I   T+Q E+
Sbjct: 265 RRIQEYLLKHYQIEHATIQMEY 286


>UniRef50_Q97NZ2 Cluster: Cation efflux system protein; n=27;
           Streptococcus|Rep: Cation efflux system protein -
           Streptococcus pneumoniae
          Length = 299

 Score = 35.5 bits (78), Expect = 1.9
 Identities = 20/74 (27%), Positives = 36/74 (48%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHV 227
           I DP LS   +  ++    P   S   + L  VPEGL    +++   R+  V ++++L++
Sbjct: 170 ILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNL 229

Query: 228 WQLHRDKVVATAHV 241
           W +   +  A  HV
Sbjct: 230 WTMDALEKNAIVHV 243


>UniRef50_Q11KC0 Cluster: Cation diffusion facilitator family
           transporter; n=28; Proteobacteria|Rep: Cation diffusion
           facilitator family transporter - Mesorhizobium sp.
           (strain BNC1)
          Length = 317

 Score = 35.5 bits (78), Expect = 1.9
 Identities = 20/61 (32%), Positives = 31/61 (50%), Gaps = 1/61 (1%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP +    A+V+  +++  +R AG VLL  +PE          A+   G   I +LHVWQ
Sbjct: 213 DPIMGVVGALVIARWSWGLIRQAGAVLLDYLPEEEELPQEIREAIEAEG-DRISDLHVWQ 271

Query: 230 L 230
           +
Sbjct: 272 I 272


>UniRef50_A6SZ19 Cluster: Cobalt-zinc-cadmium resistance protein
           CzcD; n=33; cellular organisms|Rep: Cobalt-zinc-cadmium
           resistance protein CzcD - Janthinobacterium sp. (strain
           Marseille) (Minibacterium massiliensis)
          Length = 309

 Score = 35.1 bits (77), Expect = 2.4
 Identities = 23/89 (25%), Positives = 38/89 (42%), Gaps = 2/89 (2%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DPA+    A ++ V+ Y  +R +G  LL          ++R      P   AI +LHVW+
Sbjct: 207 DPAMGIVGAALVSVWAYGLIRDSGRFLLDAEMNAPVVEEIREVIAASPIPAAICDLHVWR 266

Query: 230 LHRDK--VVATAHVIYGTHEDYLKNSALV 256
           + + K   + T  V      DY +    +
Sbjct: 267 VGKQKYACILTLAVHEAATPDYFRRQLAI 295


>UniRef50_A1B355 Cluster: Cation diffusion facilitator family
           transporter; n=3; Rhodobacteraceae|Rep: Cation diffusion
           facilitator family transporter - Paracoccus
           denitrificans (strain Pd 1222)
          Length = 311

 Score = 35.1 bits (77), Expect = 2.4
 Identities = 48/228 (21%), Positives = 88/228 (38%), Gaps = 29/228 (12%)

Query: 34  HFTNSPTLLVDTCHSLCRLVGLITTLISFKYERADEGTGREGRLRNTFGWARIEVVGRLS 93
           +  +S  L+ D  H+L   + L+    + +  R     G       ++GW R EVV    
Sbjct: 44  YVADSTALIADGVHNLSDALALVLAFGARRLARRPASPGM------SYGWGRAEVVAAFV 97

Query: 94  VHVLFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFN----AINYMLLAGS 149
            ++   + ++ L + AL   V     PP     +++  A   LL +    A+ +     S
Sbjct: 98  NYIALIAISVWLGIEALGRMVE----PPQVAGGLVMALAGFALLVDMATAALVWRAAKES 153

Query: 150 LFVIAAGLTEEWEHEAS---------------RIADPALSACAAIVLVVFNYPFMRSAGL 194
           + + AA L    +   S                +ADP L+   + V++      +     
Sbjct: 154 VNIRAAFLHNLADAAVSVAVILGGALIWAFGWHLADPVLTLLISGVILWHVGQEIGPVMR 213

Query: 195 VLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQLHRDKVVATAHVI 242
           +L+   P G+    L  A   V GV   H LH+WQ+   +   + H++
Sbjct: 214 MLMLAAPAGVDHAALIGAMAGVEGVAGAHHLHLWQIDERRTALSVHLV 261


>UniRef50_Q4PIG2 Cluster: Putative uncharacterized protein; n=1;
           Ustilago maydis|Rep: Putative uncharacterized protein -
           Ustilago maydis (Smut fungus)
          Length = 865

 Score = 35.1 bits (77), Expect = 2.4
 Identities = 46/158 (29%), Positives = 67/158 (42%), Gaps = 19/158 (12%)

Query: 110 LQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIA 169
           L+  VHSS GPPP +P +     +     N  N + +     V AA      + EASR+ 
Sbjct: 81  LETAVHSS-GPPP-WPTITYKHLLSAGTLNPTNPLRVVAHCDVDAAYA----QFEASRLG 134

Query: 170 DPALSACAAIV----LVVFNYPFMRSAGLVLLQTVPEGLGAC-DLRTAALRVPGVFAIHE 224
             A     A+     L+  NYP  R AG+   +++PE L  C DL    +     +A H 
Sbjct: 135 LDATVVPIAVQQWQGLIAVNYP-ARDAGVSRFESIPEALKKCPDLHLVHV---ATYA-HG 189

Query: 225 LHVWQLHRDKVVATAHVIYGTHEDYLKNSALVCDVFKR 262
            +    H D    T H +   H  Y + S  +  +FKR
Sbjct: 190 SNKPDYHPDPKPET-HKVSLDH--YRRESTKILTIFKR 224


>UniRef50_Q4WSP3 Cluster: Cation efflux family protein family; n=5;
           Pezizomycotina|Rep: Cation efflux family protein family
           - Aspergillus fumigatus (Sartorya fumigata)
          Length = 463

 Score = 34.7 bits (76), Expect = 3.2
 Identities = 37/175 (21%), Positives = 78/175 (44%), Gaps = 11/175 (6%)

Query: 91  RLSVHVLFASFALAL---VVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLA 147
           R+SV  +  +  LA+   +++A+ L  H+  G   R+  +    ++  +L N  +++ L+
Sbjct: 271 RVSVGSVDITAVLAISSTLISAIGLKNHARIGKAMRFAYI---ESLPSVLSNPSHFLTLS 327

Query: 148 GSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGAC 207
            S  ++   L      +  +  D  LS   +I + V     +++ G +LL +   G G  
Sbjct: 328 CSTLLLLLPLVSI---KLYKWLDVLLSVTISISMCVLGVRLVKTLGSMLLMSY-SGPGVS 383

Query: 208 DLRTAALRVPGVFAIHELHVWQLHRDKVVATAHV-IYGTHEDYLKNSALVCDVFK 261
           D+       P VF I +   WQ+H    +A   + + G+ E+ ++    +  + K
Sbjct: 384 DVIKDIEADPSVFGIDDARFWQVHYGLCMANLKIRVSGSEENLVRLRERISSLIK 438


>UniRef50_A5UXA7 Cluster: Putative uncharacterized protein
           precursor; n=2; Roseiflexus|Rep: Putative
           uncharacterized protein precursor - Roseiflexus sp. RS-1
          Length = 257

 Score = 33.9 bits (74), Expect = 5.7
 Identities = 18/58 (31%), Positives = 27/58 (46%)

Query: 128 IVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFN 185
           I GS V   L   + +   AG+L VI      +W  +A R   PA++ C  + L  F+
Sbjct: 36  IAGSIVAVTLVRVLLWQATAGALLVILPPALLKWRDDARRYGVPAMTLCVLLALQGFH 93


>UniRef50_Q97WH2 Cluster: Probable cation transport protein; n=1;
           Sulfolobus solfataricus|Rep: Probable cation transport
           protein - Sulfolobus solfataricus
          Length = 271

 Score = 33.9 bits (74), Expect = 5.7
 Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 12/109 (11%)

Query: 173 LSACAAIVLVVFNY----PFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVW 228
           L    AI+LV+ N+    P ++ A L+ ++     +    +     ++    ++H LHVW
Sbjct: 162 LDPVGAIILVILNFALSIPLLKEAFLIFMEG--SSVKIDHIMEELTKISP--SVHHLHVW 217

Query: 229 QLHRDKVVATAHVIYG---THEDYLKNSALVCDVFK-RHGIGLVTLQPE 273
            +     VAT HV      T  +  K    +CD  K ++GI  VT+Q E
Sbjct: 218 SICDHVKVATLHVKVSPNLTIAEADKIRGSICDFLKEKYGISHVTVQFE 266


>UniRef50_Q3JD39 Cluster: Putative uncharacterized protein; n=1;
           Nitrosococcus oceani ATCC 19707|Rep: Putative
           uncharacterized protein - Nitrosococcus oceani (strain
           ATCC 19707 / NCIMB 11848)
          Length = 518

 Score = 33.5 bits (73), Expect = 7.5
 Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 8/107 (7%)

Query: 88  VVGRLSVHVLFASFALALVVNALQLGVHSSHG--PPPRYPRVIVGSA---VIGLLF-NAI 141
           + G+LS H  F SF +A++V A+   V S H    P R+  + +G A    + LLF  AI
Sbjct: 306 ITGKLSPHYYFYSFVIAVLVIAINRTVFSEHSGTGPLRFRELFIGGAAAIAVLLLFPKAI 365

Query: 142 NYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPF 188
                  +  ++   LTE   H   +I    L+       V    PF
Sbjct: 366 AVQAKPPAFTMLTNALTE--LHSQGKIGKHGLAHYQMAYPVTARTPF 410


>UniRef50_A4BD66 Cluster: Na+-driven multidrug efflux pump; n=1;
           Reinekea sp. MED297|Rep: Na+-driven multidrug efflux
           pump - Reinekea sp. MED297
          Length = 442

 Score = 33.5 bits (73), Expect = 7.5
 Identities = 39/147 (26%), Positives = 65/147 (44%), Gaps = 9/147 (6%)

Query: 77  LRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGPPPRY-PRVIVGSAVIG 135
           LRNTF     E    L+  V+ A+ +L L+  +L       H P P +   V    +++ 
Sbjct: 10  LRNTF-----EKTWALAWPVILANLSLPLL--SLADAAILGHLPDPVFLAGVTAAGSLMA 62

Query: 136 LLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLV 195
            +F   N++ +  S F   A   E +      +    L A   IVL +F +P++  AG+ 
Sbjct: 63  YVFFGFNFLSMGLSGFTSQAMGREAYSDVLQVLKRYLLVASVLIVLTLFAHPWLIQAGVW 122

Query: 196 LLQTVPEGLGACDLRTAALRVPGVFAI 222
           L+ + P G+         +R+ GV AI
Sbjct: 123 LI-SPPAGVAEQSTLYLQIRMWGVPAI 148


>UniRef50_Q7PWF8 Cluster: ENSANGP00000019448; n=3; Culicidae|Rep:
           ENSANGP00000019448 - Anopheles gambiae str. PEST
          Length = 398

 Score = 33.5 bits (73), Expect = 7.5
 Identities = 16/73 (21%), Positives = 33/73 (45%)

Query: 170 DPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQ 229
           DP  +   ++++++      R +  +L+  VP  +    L      + GV  +H+L VW 
Sbjct: 325 DPICTFVFSLIVLITTVRIFRDSMRILVDAVPVDVSLERLSAELAYIEGVKTVHDLRVWS 384

Query: 230 LHRDKVVATAHVI 242
           +     V T H++
Sbjct: 385 VSTGWNVMTVHLM 397


>UniRef50_A3RS25 Cluster: CzcD; n=3; Ralstonia solanacearum|Rep:
           CzcD - Ralstonia solanacearum UW551
          Length = 439

 Score = 33.1 bits (72), Expect = 9.9
 Identities = 27/116 (23%), Positives = 54/116 (46%), Gaps = 9/116 (7%)

Query: 115 HSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAGLTEEWEHEASRIADPALS 174
           H +HG  P +  + + +A + ++ +A   +L  G+L   + G     ++   R  DP + 
Sbjct: 280 HDAHGHHPHHHDLNLRAAYLHVMADAATSVLALGAL---STG-----KYLGLRWIDPMVG 331

Query: 175 ACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTAALRVPGVFAIHELHVWQL 230
              A+V+  + Y  ++ AG VLL    +     D    AL       +++LH+W++
Sbjct: 332 IVGALVIGQWAYSLLKRAGGVLLDR-GDDPDLQDAIQRALEAESGVVVNDLHLWRV 386


>UniRef50_A0NSQ9 Cluster: Carbon monoxide dehydrogenase operon C
           protein; n=1; Stappia aggregata IAM 12614|Rep: Carbon
           monoxide dehydrogenase operon C protein - Stappia
           aggregata IAM 12614
          Length = 420

 Score = 33.1 bits (72), Expect = 9.9
 Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 13/105 (12%)

Query: 97  LFASFALALVVNALQLGVHSSHGPPPRYPRVIVGSAVIGLLFNAINYMLLAGSLFVIAAG 156
           +FASF +A     L + +    G   R P +++ +AV+ L  +A++Y  +AG        
Sbjct: 141 VFASFLIAFNAAGLAMWLLFGLG---RRPPLVISAAVLALAISAMHYTAMAG-------- 189

Query: 157 LTEEWEHEASRIADPALSACAAIVLVVFNYPFMRSAGLVLLQTVP 201
           LT E     S    PALS    + ++V    F+ S GL LL  VP
Sbjct: 190 LTYETRQPLSAGLAPALSP-GMLAILVSCVAFLVS-GLFLLALVP 232


>UniRef50_Q16990 Cluster: Mini-collagen; n=10; Cnidaria|Rep:
           Mini-collagen - Acropora donei (Coral)
          Length = 176

 Score = 33.1 bits (72), Expect = 9.9
 Identities = 16/36 (44%), Positives = 18/36 (50%), Gaps = 2/36 (5%)

Query: 283 EEEKKELIAYGNLGCSCPCVKECTGPRCCEPPNIPP 318
           E+EK+E    G  GC   C   C  P CC PP  PP
Sbjct: 22  EKEKREASPCG-YGCPSMCAPACE-PTCCAPPPPPP 55


>UniRef50_Q6UX54 Cluster: Solute carrier family 30 member 5; n=49;
           Eumetazoa|Rep: Solute carrier family 30 member 5 - Homo
           sapiens (Human)
          Length = 765

 Score = 33.1 bits (72), Expect = 9.9
 Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 8/111 (7%)

Query: 168 IADPALSACAAIVLVVFNYPFMRSAGLVLLQTVPEGLGACDLRTA---ALRVPGVFAIHE 224
           IADP  S   AI++ +   P ++ A  VLL  +P      +L  A     ++ G+ +  +
Sbjct: 620 IADPLCSLSTAILIFLSVVPLIKDACQVLLLRLPPEYEK-ELHIALEKIQKIEGLISYRD 678

Query: 225 LHVWQLHRDKVVATAHVIYGTHEDYLKNSAL--VCDVFKRHGIGLVTLQPE 273
            H W+     V  T H+      D L+   +  V  + K  G+  +T+Q E
Sbjct: 679 PHFWRHSASIVAGTIHI--QVTSDVLEQRIVQQVTGILKDAGVNNLTIQVE 727


  Database: uniref50
    Posted date:  Oct 5, 2007 11:19 AM
  Number of letters in database: 575,637,011
  Number of sequences in database:  1,657,284
  
Lambda     K      H
   0.325    0.139    0.441 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 344,258,724
Number of Sequences: 1657284
Number of extensions: 13161888
Number of successful extensions: 37547
Number of sequences better than 10.0: 209
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 37179
Number of HSP's gapped (non-prelim): 352
length of query: 322
length of database: 575,637,011
effective HSP length: 101
effective length of query: 221
effective length of database: 408,251,327
effective search space: 90223543267
effective search space used: 90223543267
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 72 (33.1 bits)

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