Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000894-TA|BGIBMGA000894-PA|IPR000308|14-3-3 protein,
IPR010989|t-snare, IPR009054|DNA topoisomerases I, dispensable insert,
eukaryotic-type, IPR009053|Prefoldin
(1630 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein p... 165 2e-39
Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein. 157 3e-37
X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein. 147 3e-34
U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein. 147 3e-34
AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golg... 147 3e-34
U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein. 144 3e-33
AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein. 135 1e-30
BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein. 134 2e-30
AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein... 134 2e-30
AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb ... 133 6e-30
X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein. 131 2e-29
BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6, ... 131 2e-29
Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heav... 129 7e-29
L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated prote... 129 9e-29
BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein pr... 128 1e-28
AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 prot... 128 1e-28
Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein. 128 2e-28
AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein. 127 3e-28
D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heav... 127 4e-28
AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein. 126 7e-28
X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein. 125 1e-27
Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein. 125 2e-27
U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protei... 125 2e-27
AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F, 3... 125 2e-27
AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F, 3... 125 2e-27
U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein. 124 2e-27
M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein. 124 3e-27
M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy ch... 124 3e-27
BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,... 124 3e-27
BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,... 124 3e-27
AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein p... 124 3e-27
X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (... 122 1e-26
Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9, no... 120 3e-26
X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy... 120 3e-26
X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain ... 120 3e-26
CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein. 120 3e-26
AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy... 120 3e-26
D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 prot... 120 4e-26
X64838-1|CAA46050.1| 1427|Homo sapiens restin protein. 118 1e-25
X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 ... 118 2e-25
X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for ... 118 2e-25
AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin he... 117 3e-25
AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY... 117 3e-25
AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein. 117 3e-25
AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein. 117 3e-25
Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated microtub... 117 4e-25
BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein. 117 4e-25
X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mR... 116 5e-25
BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein. 116 5e-25
AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical rhabdomyos... 116 5e-25
BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2, ... 116 7e-25
AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa ... 116 7e-25
AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein. 116 7e-25
BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,... 116 9e-25
BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,... 116 9e-25
AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin he... 116 9e-25
X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy ch... 115 1e-24
D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heav... 115 1e-24
AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain prot... 114 2e-24
M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle... 113 4e-24
BC117132-1|AAI17133.1| 1306|Homo sapiens kinectin 1 (kinesin rec... 113 4e-24
BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with ... 113 4e-24
BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with ... 113 4e-24
BC112337-1|AAI12338.1| 1306|Homo sapiens kinectin 1 (kinesin rec... 113 4e-24
AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein. 113 4e-24
AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein. 113 4e-24
M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain p... 113 5e-24
M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain p... 113 5e-24
EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7, ... 113 5e-24
BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7, ... 113 5e-24
BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7, ... 113 5e-24
AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypepti... 113 5e-24
AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain... 112 9e-24
AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antige... 111 2e-23
M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protei... 111 2e-23
BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containi... 110 5e-23
AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antige... 110 5e-23
AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/... 110 5e-23
BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1, ... 109 8e-23
AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome assoc... 107 2e-22
AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250... 106 8e-22
AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associ... 106 8e-22
X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein. 105 1e-21
X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin he... 105 2e-21
U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein. 105 2e-21
AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20... 105 2e-21
AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein. 105 2e-21
AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter r... 104 3e-21
AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter r... 104 3e-21
DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein. 103 5e-21
BC060769-1|AAH60769.2| 1107|Homo sapiens chromosome 6 open readi... 103 7e-21
AL365275-1|CAI40383.1| 1140|Homo sapiens chromosome 6 open readi... 102 1e-20
AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110... 102 1e-20
AL137009-1|CAI20344.1| 1140|Homo sapiens chromosome 6 open readi... 102 1e-20
AL132874-2|CAI42604.1| 1140|Homo sapiens chromosome 6 open readi... 102 1e-20
U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein. 101 2e-20
M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein. 101 2e-20
J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplak... 101 2e-20
AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein. 101 2e-20
BC090932-1|AAH90932.1| 1377|Homo sapiens NIN protein protein. 101 2e-20
AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein. 101 2e-20
AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110... 101 3e-20
AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110... 101 3e-20
AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein. 101 3e-20
AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein. 101 3e-20
AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated pr... 99 7e-20
BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-... 100 9e-20
AY651261-1|AAX35689.1| 1244|Homo sapiens centrosomal protein 1 p... 100 9e-20
AK128098-1|BAC87273.1| 1185|Homo sapiens protein ( Homo sapiens ... 100 9e-20
X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal ... 99 1e-19
AB046785-1|BAB13391.2| 1313|Homo sapiens KIAA1565 protein protein. 99 1e-19
AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein. 98 3e-19
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 97 3e-19
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 97 3e-19
AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein. 97 3e-19
AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,... 96 8e-19
AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,... 96 8e-19
Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein. 96 1e-18
BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein. 96 1e-18
AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein. 96 1e-18
AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein p... 96 1e-18
AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein ... 95 1e-18
AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein ... 95 1e-18
D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein. 95 2e-18
AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain cont... 95 2e-18
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 95 2e-18
AF223939-1|AAK00630.1| 2073|Homo sapiens ninein isotype 3 protein. 95 2e-18
AF223938-1|AAK00629.1| 2069|Homo sapiens ninein isotype 2 protein. 94 4e-18
AF223937-1|AAK00628.1| 2029|Homo sapiens ninein isotype 1 protein. 94 4e-18
AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a varian... 94 4e-18
AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein. 94 4e-18
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 94 4e-18
L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein. 93 8e-18
D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein. 93 8e-18
BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein. 93 8e-18
BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 93 1e-17
BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 93 1e-17
AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransfera... 93 1e-17
AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein. 93 1e-17
AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain cont... 92 1e-17
AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein. 92 1e-17
U29343-1|AAC52049.1| 725|Homo sapiens hyaluronan receptor protein. 92 2e-17
BX538186-1|CAD98058.1| 971|Homo sapiens hypothetical protein pr... 92 2e-17
AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein. 92 2e-17
AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein. 92 2e-17
AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein. 91 2e-17
BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 1... 91 4e-17
AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 1... 91 4e-17
AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein. 91 4e-17
BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein. 90 5e-17
BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein. 90 5e-17
BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein. 90 5e-17
AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein. 90 5e-17
AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein. 90 5e-17
AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment e... 90 5e-17
AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring prot... 90 5e-17
BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein. 90 7e-17
AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein. 90 7e-17
AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein. 90 7e-17
AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein ... 89 9e-17
AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein ... 89 9e-17
AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens ... 89 9e-17
AF302773-1|AAG33512.2| 2090|Homo sapiens ninein-Lm isoform protein. 89 9e-17
AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein. 89 9e-17
Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50 p... 89 1e-16
AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A p... 89 1e-16
AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein. 89 1e-16
AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit S... 88 2e-16
AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein. 88 2e-16
AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein. 88 2e-16
AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein. 88 2e-16
AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein. 88 2e-16
AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein. 88 2e-16
AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein. 88 2e-16
AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein. 88 2e-16
AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein. 88 2e-16
AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein. 88 2e-16
AF212162-1|AAF23015.2| 2096|Homo sapiens ninein protein. 88 2e-16
AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant... 88 2e-16
X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa pro... 88 3e-16
D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein. 88 3e-16
BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex pr... 88 3e-16
AY736182-1|AAU86898.1| 1989|Homo sapiens ninein isoform 6 protein. 88 3e-16
AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex pr... 88 3e-16
AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex pr... 88 3e-16
AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant... 88 3e-16
AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related... 88 3e-16
AB011127-1|BAA25481.2| 802|Homo sapiens KIAA0555 protein protein. 88 3e-16
AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-... 87 4e-16
AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein pr... 87 5e-16
AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex pr... 87 5e-16
AK091682-1|BAC03719.1| 936|Homo sapiens protein ( Homo sapiens ... 87 5e-16
AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin he... 87 5e-16
AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin he... 87 5e-16
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 87 7e-16
BC117174-1|AAI17175.1| 1291|Homo sapiens KIF15 protein protein. 86 9e-16
U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein. 86 1e-15
BC131805-1|AAI31806.1| 913|Homo sapiens CCDC46 protein protein. 86 1e-15
AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-... 86 1e-15
AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein... 86 1e-15
AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein. 86 1e-15
AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein. 86 1e-15
BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-... 85 2e-15
BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-... 85 2e-15
BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein. 85 2e-15
AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting cit... 85 2e-15
AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-... 85 2e-15
AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-... 85 2e-15
AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein. 85 2e-15
BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/C... 85 2e-15
BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein. 85 2e-15
AB035898-1|BAB03309.1| 1388|Homo sapiens kinesin-like protein 2 ... 85 2e-15
AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein. 85 2e-15
AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein ... 84 3e-15
AL590377-2|CAI14630.2| 1406|Homo sapiens chromosome 9 open readi... 84 3e-15
AL365436-2|CAI16590.1| 1203|Homo sapiens cingulin protein. 84 3e-15
AL354738-1|CAI16195.2| 1406|Homo sapiens chromosome 9 open readi... 84 3e-15
AL354711-1|CAH72682.2| 1406|Homo sapiens chromosome 9 open readi... 84 3e-15
AL162725-3|CAH70424.1| 1406|Homo sapiens chromosome 9 open readi... 84 3e-15
AL133214-3|CAH70743.2| 1406|Homo sapiens chromosome 9 open readi... 84 3e-15
AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens ... 84 3e-15
AF263462-1|AAF74498.1| 1203|Homo sapiens cingulin protein. 84 3e-15
AF032862-1|AAC32548.1| 724|Homo sapiens intracellular hyaluroni... 84 3e-15
AB037740-1|BAA92557.1| 1208|Homo sapiens KIAA1319 protein protein. 84 3e-15
Z11584-1|CAA77670.1| 2101|Homo sapiens NuMA protein protein. 84 5e-15
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 84 5e-15
AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein. 84 5e-15
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 84 5e-15
M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy cha... 83 6e-15
M63618-1|AAA35606.1| 2095|Homo sapiens bullous pemphigoid antige... 83 8e-15
L11690-1|AAA52288.1| 2649|Homo sapiens bullous pemphigoid antige... 83 8e-15
BC108904-1|AAI08905.1| 725|Homo sapiens hyaluronan-mediated mot... 83 8e-15
AL096710-6|CAI22047.1| 2649|Homo sapiens dystonin protein. 83 8e-15
X63105-1|CAA44819.1| 726|Homo sapiens Tpr protein. 83 1e-14
BC094764-1|AAH94764.1| 692|Homo sapiens TPR protein protein. 83 1e-14
BC016514-1|AAH16514.1| 687|Homo sapiens TPR protein protein. 83 1e-14
AK024959-1|BAB15043.1| 696|Homo sapiens protein ( Homo sapiens ... 83 1e-14
BC048203-1|AAH48203.1| 663|Homo sapiens Unknown (protein for IM... 82 2e-14
AF485338-1|AAL93149.1| 1498|Homo sapiens golgin-160 protein. 81 2e-14
DQ444714-1|ABE01857.1| 805|Homo sapiens cenexin 1 protein. 81 3e-14
DQ444713-1|ABE01856.1| 824|Homo sapiens cenexin 1 variant 1 pro... 81 3e-14
BC109126-1|AAI09127.1| 872|Homo sapiens chromosome 10 open read... 81 3e-14
BC091500-1|AAH91500.1| 829|Homo sapiens ODF2 protein protein. 81 3e-14
BC036225-1|AAH36225.1| 872|Homo sapiens chromosome 10 open read... 81 3e-14
BC010629-1|AAH10629.1| 763|Homo sapiens outer dense fiber of sp... 81 3e-14
AY366499-1|AAQ73195.1| 805|Homo sapiens outer dense fiber of sp... 81 3e-14
AL590005-3|CAI14988.1| 5457|Homo sapiens dystonin protein. 81 3e-14
AL590005-2|CAI14989.1| 7543|Homo sapiens dystonin protein. 81 3e-14
AL512448-3|CAI16610.1| 5144|Homo sapiens dystonin protein. 81 3e-14
AL512448-2|CAI16608.1| 5457|Homo sapiens dystonin protein. 81 3e-14
AL512448-1|CAI16609.1| 7543|Homo sapiens dystonin protein. 81 3e-14
AL512422-3|CAI14342.1| 5457|Homo sapiens dystonin protein. 81 3e-14
AL512422-2|CAI14341.1| 7543|Homo sapiens dystonin protein. 81 3e-14
AL445287-6|CAH71069.1| 805|Homo sapiens outer dense fiber of sp... 81 3e-14
AL359091-23|CAI13506.1| 805|Homo sapiens outer dense fiber of s... 81 3e-14
AL355378-1|CAI15667.1| 872|Homo sapiens novel protein protein. 81 3e-14
AL162742-5|CAI12110.1| 872|Homo sapiens novel protein protein. 81 3e-14
AL137008-4|CAI20332.1| 5144|Homo sapiens dystonin protein. 81 3e-14
AL137008-3|CAI20331.1| 5457|Homo sapiens dystonin protein. 81 3e-14
AL137008-2|CAI20330.1| 7543|Homo sapiens dystonin protein. 81 3e-14
AL096710-4|CAI22045.1| 5144|Homo sapiens dystonin protein. 81 3e-14
AL096710-3|CAI22044.1| 7543|Homo sapiens dystonin protein. 81 3e-14
AL096710-2|CAI22043.1| 5457|Homo sapiens dystonin protein. 81 3e-14
AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens ... 81 3e-14
AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens ... 80 7e-14
AK027705-1|BAB55310.1| 965|Homo sapiens protein ( Homo sapiens ... 80 7e-14
AF458591-1|AAM49719.1| 590|Homo sapiens hypothetical protein pr... 80 7e-14
AF400226-1|AAL62061.1| 5171|Homo sapiens bullous pemphigoid anti... 80 7e-14
U93121-1|AAB88727.1| 753|Homo sapiens M-phase phosphoprotein-1 ... 79 1e-13
D67035-1|BAA22586.1| 973|Homo sapiens SCP-1 protein. 79 1e-13
D63997-1|BAA23661.1| 1530|Homo sapiens GCP170 protein. 79 1e-13
BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for IM... 79 1e-13
BC028423-1|AAH28423.1| 1022|Homo sapiens PMFBP1 protein protein. 79 1e-13
AL589649-3|CAH71820.1| 1213|Homo sapiens filamin A interacting p... 79 1e-13
AL589649-1|CAH71818.1| 1114|Homo sapiens filamin A interacting p... 79 1e-13
AL445465-2|CAH73615.1| 1213|Homo sapiens filamin A interacting p... 79 1e-13
AL445465-1|CAH73614.1| 1114|Homo sapiens filamin A interacting p... 79 1e-13
AK097517-1|BAC05084.1| 621|Homo sapiens protein ( Homo sapiens ... 79 1e-13
AF041004-1|AAD17459.1| 1756|Homo sapiens periplakin protein. 79 1e-13
AF013717-1|AAC39668.1| 1756|Homo sapiens periplakin protein. 79 1e-13
AF001691-1|AAC17738.1| 1756|Homo sapiens 195 kDa cornified envel... 79 1e-13
AB086011-1|BAC77067.1| 1213|Homo sapiens L-FILIP protein. 79 1e-13
AB033101-1|BAA86589.1| 1140|Homo sapiens KIAA1275 protein protein. 79 1e-13
AB027133-1|BAB71953.1| 1390|Homo sapiens male enhanced antigen-2... 79 1e-13
BC070281-1|AAH70281.1| 552|Homo sapiens HMMR protein protein. 79 1e-13
AL832009-1|CAD89912.1| 1177|Homo sapiens hypothetical protein pr... 79 1e-13
AB111886-1|BAC98374.1| 1571|Homo sapiens KIAA2034 protein protein. 79 1e-13
AF091711-1|AAD39719.1| 1773|Homo sapiens splice variant AKAP350 ... 79 2e-13
BC133019-1|AAI33020.1| 1427|Homo sapiens LOC650001 protein protein. 78 2e-13
BC114620-1|AAI14621.1| 1756|Homo sapiens periplakin protein. 78 2e-13
BC057235-1|AAH57235.1| 613|Homo sapiens HMMR protein protein. 78 2e-13
AL445669-8|CAH70752.1| 783|Homo sapiens novel protein protein. 78 2e-13
AL138788-1|CAI22439.1| 783|Homo sapiens novel protein protein. 78 2e-13
AB011140-1|BAA25494.1| 1426|Homo sapiens KIAA0568 protein protein. 78 2e-13
L01042-1|AAD54608.1| 1093|Homo sapiens TATA element modulatory f... 78 3e-13
BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein. 78 3e-13
AF011368-1|AAB84386.1| 761|Homo sapiens CEV14 protein. 78 3e-13
AB059622-1|BAB69690.1| 1594|Homo sapiens Rb1-inducible coiled co... 78 3e-13
BC126912-1|AAI26913.1| 1132|Homo sapiens CROCC protein protein. 77 4e-13
BC126911-1|AAI26912.1| 1132|Homo sapiens CROCC protein protein. 77 4e-13
BC101470-1|AAI01471.1| 1478|Homo sapiens FYVE and coiled-coil do... 77 5e-13
BC101468-1|AAI01469.1| 1478|Homo sapiens FYVE and coiled-coil do... 77 5e-13
AB040942-1|BAA96033.1| 1326|Homo sapiens KIAA1509 protein protein. 77 5e-13
AL445287-5|CAH71068.1| 765|Homo sapiens outer dense fiber of sp... 77 7e-13
AL359091-22|CAI13505.1| 765|Homo sapiens outer dense fiber of s... 77 7e-13
AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protei... 77 7e-13
AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protei... 77 7e-13
AB018346-1|BAA34523.1| 1708|Homo sapiens KIAA0803 protein protein. 77 7e-13
BC127772-1|AAI27773.1| 863|Homo sapiens KIF5C protein protein. 76 9e-13
BC110287-1|AAI10288.1| 725|Homo sapiens KIF5C protein protein. 76 9e-13
BC060037-1|AAH60037.1| 622|Homo sapiens KIAA1212 protein protein. 76 9e-13
BC013023-1|AAH13023.1| 1193|Homo sapiens NUMA1 protein protein. 76 9e-13
AC108512-1|AAX82030.1| 684|Homo sapiens unknown protein. 76 9e-13
AB053469-1|BAC54108.1| 720|Homo sapiens ELKS gamma protein. 76 9e-13
AB011103-1|BAA25457.2| 999|Homo sapiens KIAA0531 protein protein. 76 9e-13
X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (... 76 1e-12
M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain beta-s... 76 1e-12
M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac m... 76 1e-12
AL138742-1|CAI22698.1| 1325|Homo sapiens KIAA1009 protein. 76 1e-12
AK055217-1|BAB70876.1| 688|Homo sapiens protein ( Homo sapiens ... 76 1e-12
AB023226-1|BAA76853.2| 1345|Homo sapiens KIAA1009 protein protein. 76 1e-12
AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protei... 75 2e-12
AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protei... 75 2e-12
BC043398-1|AAH43398.1| 805|Homo sapiens CEP290 protein protein. 75 2e-12
Z54367-1|CAA91196.1| 4684|Homo sapiens plectin protein. 75 3e-12
U51587-1|AAB81549.1| 767|Homo sapiens Golgi complex autoantigen... 75 3e-12
D86958-1|BAA13194.2| 1593|Homo sapiens KIAA0203 protein. 75 3e-12
BC017556-1|AAH17556.1| 1594|Homo sapiens RB1-inducible coiled-co... 75 3e-12
AL451125-2|CAI14346.1| 767|Homo sapiens golgi autoantigen, golg... 74 4e-12
AL354928-1|CAI39632.1| 767|Homo sapiens golgi autoantigen, golg... 74 4e-12
AL137068-3|CAI12356.1| 828|Homo sapiens centrosomal protein 110... 74 4e-12
AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protei... 74 4e-12
AB011137-1|BAA25491.2| 641|Homo sapiens KIAA0565 protein protein. 74 4e-12
L06148-1|AAA35921.1| 579|Homo sapiens golgin-165 protein. 74 5e-12
BC126123-1|AAI26124.1| 1093|Homo sapiens TATA element modulatory... 74 5e-12
BC125086-1|AAI25087.1| 634|Homo sapiens CCDC41 protein protein. 74 5e-12
BC117418-1|AAI17419.1| 1093|Homo sapiens TATA element modulatory... 74 5e-12
BC032853-1|AAH32853.1| 767|Homo sapiens golgi autoantigen, golg... 74 5e-12
AL137068-4|CAI12357.1| 994|Homo sapiens centrosomal protein 110... 74 5e-12
AB209109-1|BAD92346.1| 1096|Homo sapiens TATA element modulatory... 74 5e-12
AB208841-1|BAD92078.1| 1585|Homo sapiens Nuclear mitotic apparat... 74 5e-12
AB014535-1|BAA31610.2| 864|Homo sapiens KIAA0635 protein protein. 74 5e-12
X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac m... 73 6e-12
U63610-1|AAB05428.1| 4574|Homo sapiens plectin protein. 73 6e-12
U53204-1|AAB05427.1| 4574|Homo sapiens plectin protein. 73 6e-12
BX538286-1|CAD98081.1| 724|Homo sapiens hypothetical protein pr... 73 6e-12
AC002563-2|AAB71327.1| 1286|Homo sapiens WUGSC:H_127H14.1 protein. 73 6e-12
AB208965-1|BAD92202.1| 705|Homo sapiens Rho-associated, coiled-... 73 9e-12
EF512550-1|ABP62932.1| 820|Homo sapiens neuroendocrine long coi... 73 1e-11
BC017354-1|AAH17354.1| 810|Homo sapiens janus kinase and microt... 73 1e-11
AY639646-1|AAX19141.1| 572|Homo sapiens prefoldin subunit 6-lik... 73 1e-11
AF273057-1|AAM44460.1| 810|Homo sapiens CTCL tumor antigen HD-C... 73 1e-11
AF273044-1|AAG34904.1| 761|Homo sapiens CTCL tumor antigen se2-... 73 1e-11
M21665-1|AAA36345.1| 524|Homo sapiens protein ( Human beta-myos... 72 2e-11
BC006984-1|AAH06984.1| 512|Homo sapiens Unknown (protein for IM... 72 2e-11
L09190-1|AAA65582.1| 1898|Homo sapiens trichohyalin protein. 71 3e-11
BC056146-1|AAH56146.1| 718|Homo sapiens hook homolog 3 (Drosoph... 71 3e-11
AY739715-1|AAW65984.1| 617|Homo sapiens M-phase phosphoprotein ... 71 3e-11
AF241830-1|AAK29204.1| 718|Homo sapiens golgi-associated microt... 71 3e-11
M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myo... 71 3e-11
AL590708-22|CAI13842.1| 952|Homo sapiens golgi autoantigen, gol... 71 3e-11
AL031283-6|CAI21428.1| 692|Homo sapiens forkhead-associated (FH... 71 3e-11
U73682-1|AAB86589.1| 776|Homo sapiens meningioma-expressed anti... 71 5e-11
BC069268-1|AAH69268.1| 990|Homo sapiens golgi autoantigen, golg... 71 5e-11
AL590708-21|CAI13841.1| 990|Homo sapiens golgi autoantigen, gol... 71 5e-11
AK023677-1|BAB14636.1| 574|Homo sapiens protein ( Homo sapiens ... 71 5e-11
AF535142-1|AAN03486.1| 8749|Homo sapiens enaptin protein. 71 5e-11
AF248953-1|AAF65550.1| 990|Homo sapiens golgi matrix protein GM... 71 5e-11
BC117182-1|AAI17183.1| 1654|Homo sapiens CEP152 protein protein. 70 6e-11
BC103765-1|AAI03766.1| 691|Homo sapiens NUMA1 protein protein. 70 6e-11
BC046212-1|AAH46212.1| 364|Homo sapiens Similar to cytomatrix p... 70 6e-11
BC027493-1|AAH27493.1| 691|Homo sapiens Unknown (protein for IM... 70 6e-11
AF338234-1|AAN77611.1| 771|Homo sapiens CTAGE-5B protein protein. 70 6e-11
AF338233-1|AAN77610.1| 775|Homo sapiens CTAGE-5A protein protein. 70 6e-11
AB209528-1|BAD92765.1| 808|Homo sapiens CTAGE family, member 5 ... 70 6e-11
U94780-1|AAB86593.1| 804|Homo sapiens MEA6 protein. 70 8e-11
BC064355-1|AAH64355.1| 809|Homo sapiens CTAGE5 protein protein. 70 8e-11
AB067524-1|BAB67830.1| 704|Homo sapiens KIAA1937 protein protein. 70 8e-11
DQ120669-1|ABB92450.1| 681|Homo sapiens rcCTAGE5 protein. 69 1e-10
BC103499-1|AAI03500.1| 898|Homo sapiens chromosome 10 open read... 69 1e-10
BC051363-1|AAH51363.2| 729|Homo sapiens CTAGE family, member 5 ... 69 1e-10
Z98949-1|CAI17892.1| 2566|Homo sapiens protein ( Human DNA seque... 69 1e-10
BC050548-1|AAH50548.1| 1127|Homo sapiens KIF4A protein protein. 69 1e-10
BC036527-1|AAH36527.1| 811|Homo sapiens CTAGEP protein protein. 69 1e-10
AY165122-1|AAO39147.1| 1995|Homo sapiens myosin heavy chain prot... 69 1e-10
AL357752-3|CAI41487.1| 1232|Homo sapiens kinesin family member 4... 69 1e-10
AL139398-5|CAI41024.1| 1232|Homo sapiens kinesin family member 4... 69 1e-10
AL080245-1|CAI16965.1| 2566|Homo sapiens protein ( Human DNA seq... 69 1e-10
AL079300-1|CAI17881.1| 2566|Homo sapiens protein ( Human DNA seq... 69 1e-10
AL022329-3|CAI17968.1| 2566|Homo sapiens protein ( Human DNA seq... 69 1e-10
AB208797-1|BAD92034.1| 1235|Homo sapiens Chromosome-associated k... 69 1e-10
AB020719-1|BAA74935.1| 1300|Homo sapiens KIAA0912 protein protein. 69 1e-10
DQ139275-1|ABA43896.1| 1313|Homo sapiens Tax1-binding protein 2 ... 69 2e-10
U72849-1|AAD00186.1| 2033|Homo sapiens envoplakin protein. 68 2e-10
U53786-1|AAC64662.1| 2033|Homo sapiens envoplakin protein. 68 2e-10
BC126105-1|AAI26106.1| 2033|Homo sapiens envoplakin protein. 68 2e-10
BC126103-1|AAI26104.1| 2033|Homo sapiens envoplakin protein. 68 2e-10
BC004165-1|AAH04165.1| 979|Homo sapiens NUMA1 protein protein. 68 2e-10
AF461266-1|AAL67520.1| 606|Homo sapiens RUFY2 protein. 68 2e-10
AF411980-1|AAL04164.1| 590|Homo sapiens Run- and FYVE-domain co... 68 2e-10
AB040970-1|BAA96061.1| 619|Homo sapiens KIAA1537 protein protein. 68 2e-10
BC105632-1|AAI05633.1| 898|Homo sapiens chromosome 10 open read... 68 3e-10
BC100670-1|AAI00671.1| 1004|Homo sapiens C10orf118 protein protein. 68 3e-10
AL139421-4|CAI22511.1| 720|Homo sapiens coiled-coil domain cont... 68 3e-10
AF254756-1|AAK13079.1| 698|Homo sapiens predicted testis protei... 68 3e-10
AC019097-1|AAY14820.1| 698|Homo sapiens unknown protein. 68 3e-10
BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting p... 67 4e-10
AL627308-5|CAH71336.1| 1732|Homo sapiens CDC42 binding protein k... 67 4e-10
AL627308-3|CAH71337.1| 1719|Homo sapiens CDC42 binding protein k... 67 4e-10
AL451047-3|CAH71185.1| 1732|Homo sapiens CDC42 binding protein k... 67 4e-10
AL451047-1|CAH71183.1| 1719|Homo sapiens CDC42 binding protein k... 67 4e-10
AL353689-9|CAI19109.1| 1732|Homo sapiens CDC42 binding protein k... 67 4e-10
AL353689-7|CAI19108.1| 1719|Homo sapiens CDC42 binding protein k... 67 4e-10
AJ518975-1|CAD57745.1| 1719|Homo sapiens CDC42 binding protein k... 67 4e-10
AF317887-1|AAK01919.1| 589|Homo sapiens monoclonal antibody 3H1... 67 4e-10
AB208968-1|BAD92205.1| 1702|Homo sapiens CDC42 binding protein k... 67 4e-10
Y15164-1|CAA75436.1| 1012|Homo sapiens Cxorf5 (71-7A) protein pr... 67 6e-10
U22816-1|AAC50173.1| 1202|Homo sapiens LAR-interacting protein 1... 67 6e-10
U22815-1|AAC50172.1| 1185|Homo sapiens LAR-interacting protein 1... 67 6e-10
BX537985-1|CAD97945.1| 1202|Homo sapiens hypothetical protein pr... 67 6e-10
BC050555-1|AAH50555.1| 873|Homo sapiens KTN1 protein protein. 67 6e-10
BC028366-1|AAH28366.1| 698|Homo sapiens testis specific, 10 pro... 67 6e-10
AK131080-1|BAC85130.1| 563|Homo sapiens FLJ00279 protein protein. 67 6e-10
BX537964-1|CAD97928.1| 898|Homo sapiens hypothetical protein pr... 66 7e-10
BC034046-1|AAH34046.1| 1202|Homo sapiens protein tyrosine phosph... 66 7e-10
BC003189-1|AAH03189.1| 365|Homo sapiens Unknown (protein for IM... 66 7e-10
AJ310932-1|CAC70714.3| 2567|Homo sapiens myosin heavy chain prot... 66 7e-10
AJ310931-1|CAC70712.2| 2567|Homo sapiens myosin heavy chain prot... 66 7e-10
AJ271784-1|CAB75427.1| 1232|Homo sapiens chromokinesin protein. 66 7e-10
AB075376-1|BAC16363.1| 2567|Homo sapiens bk125H2.1 protein. 66 7e-10
AB042648-1|BAB55550.2| 2080|Homo sapiens bk125H2.1 protein. 66 7e-10
BC132871-1|AAI32872.1| 745|Homo sapiens cutaneous T-cell lympho... 66 1e-09
BC031065-1|AAH31065.2| 780|Homo sapiens CTAGE1 protein protein. 66 1e-09
AK055189-1|BAB70870.1| 1174|Homo sapiens protein ( Homo sapiens ... 66 1e-09
AK025632-1|BAB15196.1| 720|Homo sapiens protein ( Homo sapiens ... 66 1e-09
AF179308-1|AAD51855.1| 1232|Homo sapiens KIF4 protein. 66 1e-09
AF155115-1|AAD42881.1| 472|Homo sapiens NY-REN-58 antigen protein. 66 1e-09
AF034799-1|AAC26100.1| 1257|Homo sapiens liprin-alpha2 protein. 66 1e-09
BC038515-1|AAH38515.1| 796|Homo sapiens CCDC110 protein protein. 66 1e-09
BC028419-1|AAH28419.1| 833|Homo sapiens coiled-coil domain cont... 66 1e-09
AY528714-1|ABB04050.1| 487|Homo sapiens rhabdomyosarcoma antige... 66 1e-09
AY014284-1|AAK27309.1| 699|Homo sapiens nucleoporin NYD-SP7 pro... 66 1e-09
AF071592-1|AAD05492.2| 1232|Homo sapiens kinesin superfamily mot... 66 1e-09
AB080722-1|BAC81776.1| 833|Homo sapiens hypothetical protein pr... 66 1e-09
X03445-1|CAA27174.1| 572|Homo sapiens protein ( Human mRNA for ... 65 2e-09
X03444-1|CAA27173.1| 702|Homo sapiens protein ( Human mRNA for ... 65 2e-09
M13451-1|AAA36164.1| 572|Homo sapiens protein ( Human lamin C m... 65 2e-09
BC014507-1|AAH14507.1| 664|Homo sapiens lamin A/C protein. 65 2e-09
BC014050-1|AAH14050.1| 495|Homo sapiens centrosomal protein 63k... 65 2e-09
BC003162-1|AAH03162.1| 572|Homo sapiens lamin A/C protein. 65 2e-09
BC000511-1|AAH00511.1| 572|Homo sapiens lamin A/C protein. 65 2e-09
AY847597-1|AAW32540.1| 664|Homo sapiens lamin A/C transcript va... 65 2e-09
AY847596-1|AAW32539.1| 480|Homo sapiens lamin A/C transcript va... 65 2e-09
AY357727-1|AAR29466.1| 614|Homo sapiens progerin protein. 65 2e-09
AL135927-4|CAI15523.1| 614|Homo sapiens lamin A/C protein. 65 2e-09
AL135927-3|CAI15522.1| 664|Homo sapiens lamin A/C protein. 65 2e-09
AL135927-2|CAI15520.1| 465|Homo sapiens lamin A/C protein. 65 2e-09
AL135927-1|CAI15521.1| 572|Homo sapiens lamin A/C protein. 65 2e-09
DQ120629-1|ABB92415.1| 1185|Homo sapiens KIF4B protein. 65 2e-09
BC125087-1|AAI25088.1| 568|Homo sapiens CCDC41 protein protein. 65 2e-09
AY847595-1|AAW32538.1| 664|Homo sapiens lamin A/C transcript va... 65 2e-09
AY077700-1|AAL75811.1| 2568|Homo sapiens myosin-like protein pro... 65 2e-09
AK093227-1|BAC04102.1| 550|Homo sapiens protein ( Homo sapiens ... 65 2e-09
AK025336-1|BAB15114.1| 963|Homo sapiens protein ( Homo sapiens ... 65 2e-09
AF272390-1|AAF78783.1| 1742|Homo sapiens myosin 5c protein. 65 2e-09
BX640704-1|CAE45824.1| 594|Homo sapiens hypothetical protein pr... 64 3e-09
BX530088-3|CAI95786.1| 841|Homo sapiens GRIP1 associated protei... 64 3e-09
BX530088-2|CAI95785.1| 796|Homo sapiens GRIP1 associated protei... 64 3e-09
BC101546-1|AAI01547.1| 841|Homo sapiens GRIP1 associated protei... 64 3e-09
BC101544-1|AAI01545.1| 841|Homo sapiens GRIP1 associated protei... 64 3e-09
BC023021-1|AAH23021.1| 731|Homo sapiens golgi autoantigen, golg... 64 3e-09
AY644768-1|AAV85456.1| 731|Homo sapiens cell proliferation-indu... 64 3e-09
AF273058-1|AAK63198.1| 754|Homo sapiens CTAGE-2 protein. 64 3e-09
AF273054-1|AAM44457.1| 613|Homo sapiens CTCL tumor antigen HD-C... 64 3e-09
AF085199-1|AAD09753.1| 731|Homo sapiens golgin-84 protein. 64 3e-09
AB032993-1|BAA86481.1| 834|Homo sapiens KIAA1167 protein protein. 64 3e-09
BX530088-4|CAI95787.1| 625|Homo sapiens GRIP1 associated protei... 64 4e-09
BC111801-1|AAI11802.1| 703|Homo sapiens ROCK2 protein protein. 64 4e-09
AL833273-1|CAD91152.1| 1509|Homo sapiens hypothetical protein pr... 64 4e-09
AB007923-1|BAA32299.2| 2296|Homo sapiens KIAA0454 protein protein. 64 4e-09
BC033088-1|AAH33088.1| 465|Homo sapiens LMNA protein protein. 64 5e-09
AK127744-1|BAC87110.1| 600|Homo sapiens protein ( Homo sapiens ... 64 5e-09
AK056465-1|BAB71192.1| 703|Homo sapiens protein ( Homo sapiens ... 64 5e-09
AK000990-1|BAA91457.1| 535|Homo sapiens protein ( Homo sapiens ... 64 5e-09
AF495910-1|AAN60442.1| 8797|Homo sapiens nesprin-1 protein. 64 5e-09
AB046810-1|BAB13416.2| 1393|Homo sapiens KIAA1590 protein protein. 64 5e-09
U53445-1|AAA98972.1| 752|Homo sapiens DOC1 protein. 63 7e-09
BC104912-1|AAI04913.1| 1236|Homo sapiens PPFIA2 protein protein. 63 7e-09
AB210009-1|BAE06091.1| 1258|Homo sapiens PPFIA2 variant protein ... 63 7e-09
AY166853-1|AAO17292.1| 1317|Homo sapiens kinesin motor protein p... 63 9e-09
AL590452-8|CAH72528.1| 2240|Homo sapiens phosphodiesterase 4D in... 63 9e-09
AL138796-7|CAI22827.1| 2240|Homo sapiens phosphodiesterase 4D in... 63 9e-09
AL118509-3|CAI43063.2| 1392|Homo sapiens chromosome 20 open read... 63 9e-09
AL118509-2|CAM28305.1| 1317|Homo sapiens chromosome 20 open read... 63 9e-09
AL117376-3|CAI43180.2| 1392|Homo sapiens chromosome 20 open read... 63 9e-09
AL117376-2|CAI43181.2| 1317|Homo sapiens chromosome 20 open read... 63 9e-09
AL049794-2|CAI22745.2| 1392|Homo sapiens chromosome 20 open read... 63 9e-09
AL049794-1|CAM28307.1| 1317|Homo sapiens chromosome 20 open read... 63 9e-09
AB032945-1|BAA86433.2| 1854|Homo sapiens KIAA1119 protein protein. 63 9e-09
BC014109-1|AAH14109.1| 670|Homo sapiens leucine rich repeat con... 62 1e-08
>AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein
protein.
Length = 2585
Score = 165 bits (400), Expect = 2e-39
Identities = 278/1364 (20%), Positives = 594/1364 (43%), Gaps = 136/1364 (9%)
Query: 297 KQSIEPSCEEKTEIEEKGSLEIANM----TELTKKIELLEHLNCQIRQT-----NKELEN 347
K+ +E +EK +++E +LE EL+ K+ELL QI++ +++LEN
Sbjct: 526 KEEMELKLKEKNDLDEFEALERKTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLEN 585
Query: 348 KLATMGTESKAVSSPSKKGSPLISRKS----GRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+ +++ P + L ++ + ++ ++S +L + T K
Sbjct: 586 IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM 645
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK--DTLIAQLQLE------ 455
+N+I + +++ K VD E + GK L+ L+LE
Sbjct: 646 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 705
Query: 456 ----HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV----KD-LIEKLK 506
+++ E +L ++ + E+L++E+ D+ +++++ KD L ++
Sbjct: 706 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 765
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ--KTI--DNFSKVSDSNKEIVRLTE 562
E ++ L +EI ++ +SN+K ++ Q KT+ D K +E R+ +
Sbjct: 766 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 825
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIES--DVYKKMIEMENLAETRLKAISLLE 620
E+ +LS++ + + G L+ L Y + + E +V +++ EME L E S L+
Sbjct: 826 EIVNLSKEAQKFDSSLGALKTEL-SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQ 884
Query: 621 SQKFDLVQELHILQQKYDEVE---DKLADISQLQSD-QVCSEIKSVHLEEQIDALSASKK 676
+ + + LQQ +EV+ + D+ QLQ Q+ + + + ++ +++
Sbjct: 885 TVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQE 944
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDK-------EDIMNKLQNYIQENMDLTDKLEKMSA 729
+L +E+LK +E + T+K +++ E+ + ++ Q+ M DK + + A
Sbjct: 945 QLRNALESLKQHQETI-NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1003
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+ L A + E I+ Q I + IQE++ + +ES +++ + L+E+I +
Sbjct: 1004 KNTQTLTADVKDNEI--IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1061
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDH-----DRVVEKQ- 840
+ + L D+L + + + +E EL +RLA + + ++ EKQ
Sbjct: 1062 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQ 1121
Query: 841 -LLEIEHENKELQKK-NQI--LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
LL ++ E E+QKK N+I L E +N +++L M+ L +K N TK
Sbjct: 1122 QLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKE 1181
Query: 897 QTQLRDLESN-------LKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ L++L+ + L+ E + +Q K+E++ I E+ ++ ++EK
Sbjct: 1182 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1241
Query: 950 YEK--NIEYVTQLEAQLQE---YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
+ N + + + +LQE + + L NV+E+++ + + + +Q+ + D T
Sbjct: 1242 TAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1301
Query: 1005 EQYINEINKL--NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
E+ +L N ++ EEI +L ++ +N + ++ ++ L ++E
Sbjct: 1302 TLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1361
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
+ +Q L+ K+ + E +V E + Q K L E+ E + +S ++
Sbjct: 1362 SQSK-QEQSLNMKEKDNETTKIVSEME-QFKPKDSALLRIEI-----EMLGLSKRLQESH 1414
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLN 1182
D+ +V +E+++ + + VLQ +S +L ++E K LET
Sbjct: 1415 DEMKSV---------------AKEKDDLQRLQEVLQSESDQLKENIKEIVAK--HLETEE 1457
Query: 1183 TELTGHDVVNQEQ--INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
H + +++ IN+L+ L + TE +ST+ + +I+ + + EI E +
Sbjct: 1458 ELKVAHCCLKEQEETINELRVNLSEKETE----ISTIQKQLEAINDKLQNKIQEIYEKEE 1513
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQ 1300
Q ++ ++ Q+ +EL+ Q + L S++S E TN++ E +Q ++
Sbjct: 1514 QFNIKQISEVQEKVNELK-QFKEHRKAKDSALQSIESKMLELTNRL--QESQEEIQIMIK 1570
Query: 1301 DKEEHLRNLQEKYADVINQI-----EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
+KEE ++ +QE +Q+ EI+ E ++ + ++
Sbjct: 1571 EKEE-MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1629
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
+ + + Q+ ++ NI EN +L + +D + + L+++ +
Sbjct: 1630 KEQF-ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS----VEETLKVERDQ 1684
Query: 1416 IYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL---TYEKESELAILRLKMHENANH 1472
+ + E ++ +E + V L E+++ I+ L EK +E++ M ++ H
Sbjct: 1685 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS----NMQKDLEH 1740
Query: 1473 YETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
K ++ K+ EEL + + + +L + E+ K + MQ LEN +
Sbjct: 1741 SNDALKAQDL---KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK 1797
Query: 1533 IVTLNDEI-TNLQNMV--RASSSKIQKHVSFASD-TKQGRDEQL 1572
+ E+ N ++ + ++ QK VS KQ +D+ L
Sbjct: 1798 LQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1841
Score = 132 bits (320), Expect = 8e-30
Identities = 318/1563 (20%), Positives = 670/1563 (42%), Gaps = 193/1563 (12%)
Query: 91 SESLANTLKQKEILMEKIKQYKE-LSKRSSTT-IVRXXXXXXXXXXXXXXXQLGDVTHLS 148
++ L ++ + + +++Q KE L R ST V ++ +T
Sbjct: 852 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 911
Query: 149 NTIKEKDNALSVL--QVKMKIMETTIL--DLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
+ +K+ +L + Q+K I +T + D QE++ + ++ +
Sbjct: 912 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 971
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLE-EANKLLEAA 263
E+T + + Q+ + + D+KQ D+E+K+ + + + + N+++E
Sbjct: 972 SRNLHMEENTGETKDEFQQKMVGI-----DKKQ----DLEAKNTQTLTADVKDNEIIEQQ 1022
Query: 264 RFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEI-----EEKGSLEI 318
R SL K EL+Q K++IE + E + E+ E K EI
Sbjct: 1023 RKIFSLIQEK--NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1080
Query: 319 ANMT---------ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL 369
EL++ + L + ++++ +++L+ K + + +S KK + +
Sbjct: 1081 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1140
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN-----EIAKLEMVIQSLNKDL-VD 423
+ K N + + +E L + +K+N+N I K V++ L K +
Sbjct: 1141 ENLK---NELKNKELTLEHMETERL--ELAQKLNENYEEVKSITKERKVLKELQKSFETE 1195
Query: 424 KEYVISEKDTXXXXXXXXXXGKDTL-IAQLQL-EHQQHM-EGPSLIHVGT----NTEDVN 476
++++ + K+ L IA + L EHQ+ + E + T NT+D+
Sbjct: 1196 RDHL---RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLE 1252
Query: 477 EI-AKVQEQL-----KQELNDEIKDVN-VKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+ K+QE++ +QEL +K+V+ ++ + +L+ EQ T D A M ++
Sbjct: 1253 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT-KDSTTLARIEMERL 1311
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH-----HLSQKVAELEEEKGNLQLH 584
+ N K + + Q+ I + +K D+ K I E H H+ + +A+++E + +
Sbjct: 1312 RLNEKFQ--ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQS 1369
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL---VQELHILQQKYDEVE 641
L + + +++ K + EME + + A+ +E + L +QE H + + +
Sbjct: 1370 L----NMKEKDNETTKIVSEMEQF-KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1424
Query: 642 D---KLADISQLQSDQVCSEIKSV---HLE--EQIDALSASKKELALVIENLKLDKEQLY 693
D +L ++ Q +SDQ+ IK + HLE E++ KE I L+++ +
Sbjct: 1425 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1484
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
I ++ E I +KLQN IQE + +K E+ + ++ISE+ K+N +Q K +
Sbjct: 1485 TEISTIQKQLEAINDKLQNKIQE---IYEKEEQFNIKQISEVQEKVNELKQFKEHRK--- 1538
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
+D +++IES++ + +R+ +E I +M + ++R + L Q ++
Sbjct: 1539 -----AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL----QIERDQL 1589
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI--LLEENQNLQISLSD 871
E T E+V + M + E Q L++ N+ +K +I L E+ + +++L +
Sbjct: 1590 KENT---KEIVAK----MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1642
Query: 872 MQQHYNALVEKANRTDLAESES-TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
++ N + + +L E S TK + LR +E LK V++ + E+L
Sbjct: 1643 IETE-NIRLTQILHENLEEMRSVTKERDDLRSVEETLK----------VERDQLKENLRE 1691
Query: 931 EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELID 990
+E + K+++ +++ E + +L + E N I N+ ++E N L+ D
Sbjct: 1692 TITRDLEKQ-EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA-LKAQD 1749
Query: 991 KHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKL 1050
+Q++ + + ++ I+KL ++ +K + K++N Q D E+
Sbjct: 1750 LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD-------KLSNMQ-------KDLENSN 1795
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
A KL+ +E++ QL+ K+ E Q V E + K++K+ LT ++ + E
Sbjct: 1796 A----KLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT--LSKLEIE 1849
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE--EFIQE---RSVLQEQSAK-- 1163
+ ++ + ++ +V LK++ ++ E +QE R + +Q K
Sbjct: 1850 NLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1909
Query: 1164 --LNTELQECYTKI--------IQLETLNTEL-TGHDVVNQE---QINQLKSKLEQLNTE 1209
L+ E +E K+ IQ+ + +L D + ++ Q +Q+K + L+
Sbjct: 1910 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDG 1969
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLA---QREADFQKTEHELRVQ---- 1260
+L ++ E S I + +R E+ + ++ L+ ++E +FQK E +RV+
Sbjct: 1970 QQHLTESLREKCSRIKELL-KRYSEMDDHYECLNRLSLDLEKEIEFQK-ELSMRVKANLS 2027
Query: 1261 LSAFESKY-EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEKYADVIN 1318
L ++K+ E+L + Q + E + ++ V S K+++++ E + + + D +
Sbjct: 2028 LPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2087
Query: 1319 QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLK 1378
+ + L +I+ + DL E + K E +I E Q+
Sbjct: 2088 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIE-EILKDFSESEFPSIKTEFQQVL 2146
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVR 1438
+ D E +L + ++ ++ I Q + + N+ +
Sbjct: 2147 SNRKEMTQFLEEWLNTRFDIE----KLKNGIQKENDRICQVNNFF-------NNRIIAIM 2195
Query: 1439 QQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE-SEIERVK--LIEELNVKI 1495
+ E+E+R ++ E E +L L+ K + +Y+T++ + +V + N +
Sbjct: 2196 NESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHV 2255
Query: 1496 TESVS--LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
T + +++ EL +L E ++ + + E+ ND I LQ V S+
Sbjct: 2256 TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC 2315
Query: 1554 IQK 1556
++K
Sbjct: 2316 LEK 2318
Score = 128 bits (308), Expect = 2e-28
Identities = 257/1487 (17%), Positives = 615/1487 (41%), Gaps = 112/1487 (7%)
Query: 93 SLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIK 152
S L++KE ++K+++Y + K + + L D ++ K
Sbjct: 559 SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAK 618
Query: 153 EKDNALSV----LQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXX 208
+ L L+ KMK + TT ++ I +EAK K
Sbjct: 619 RESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT 678
Query: 209 XXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS 268
++ K + +E + D ++ L K++E + +L E LL + +
Sbjct: 679 KLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENE----ALREEVILLSELK-SLP 733
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE------IANMT 322
E +L +E++ L + + + +EE G + +N
Sbjct: 734 SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK 793
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK-GSPLISRKSGRNTASK 381
++ + + L+ Q K + + M E +S ++K S L + K+ + ++
Sbjct: 794 STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ 853
Query: 382 MKSPWSQLSSETLNQ-DTDKKINKNEIAKLE-------MVIQSLNKDLVDKEYVISEKDT 433
++ E LN+ + K+ +N + L+ ++ + L + L + + + EKD
Sbjct: 854 ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDD 913
Query: 434 XXXXXXXXXXGKDTL------IAQLQLEHQQHMEGPSLIHVGTNTEDVNEI-AKVQEQLK 486
+D L + ++ Q+ + +L + + E +N + +K+ E++
Sbjct: 914 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN-ALESLKQHQETINTLKSKISEEVS 972
Query: 487 QELNDEIKDVNVKDL-------IEKLKSAEEQITQL-------NDEIDAANKNMIKVKSN 532
+ L+ E KD I+K + E + TQ N+ I+ K ++
Sbjct: 973 RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK 1032
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLT----EELHHLSQKVAELEEEKGNLQLHLVDY 588
++L+ + ++ I ++ KE + +T EEL L ++ + +E + H +
Sbjct: 1033 NELQ-QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKK 1091
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE------- 641
+ G + S ++ E+E + + + + + Q ++ +E+ +Q+K +E+E
Sbjct: 1092 E-GEL--SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1148
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE- 700
+K + ++++++ K E++ +++ +K L + ++ + +++ L G I+++E
Sbjct: 1149 NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA 1208
Query: 701 ---NDKEDIMNKLQN-YIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK 756
KE++ K+ + +++E+ + D+L + +EK +++ IN ++ K T K
Sbjct: 1209 TGLQTKEEL--KIAHIHLKEHQETIDELRRSVSEKTAQI---INTQDLEKSHT------K 1257
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY 816
+QE ++ + + E EL + +E++ +E K + ++ ++ +E
Sbjct: 1258 LQE-EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1316
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQ---ISLSDM 872
+ E + L D+ + + K+ LE++H+ KE ++ ++E+Q+ Q +++ +
Sbjct: 1317 FQESQEEIKSLTKERDNLKTI-KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1375
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEF 932
+V + + +S + + ++ L L+ +H+ + ++K +++ L+
Sbjct: 1376 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE-SHDEMKSVAKEKDDLQRLQEVL 1434
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
++ + + K + K+ + E + L+E + I L +N+ E + + I K
Sbjct: 1435 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE-KETEISTIQKQ 1493
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
++ + + ++ + + N + +E + ++ + + S + ESK+ +
Sbjct: 1494 LEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLE 1553
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE-LKETKLTFEMNIPKTEG 1111
T +L+ +EE+Q + K+ + K+ E LQI + DQ+KE KE + + K
Sbjct: 1554 LTNRLQESQEEIQIMIKEKEEMKRVQEALQI----ERDQLKENTKEIVAKMKESQEKEYQ 1609
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ + + + ++ L+ E E I+ +L E ++ + +E
Sbjct: 1610 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLE-NIETENIRLTQILHENLEEMRSVTKER 1668
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNL---LSTVAELRSSISSAV 1228
ETL E +E I + K E+L + +L T+ +LR +S
Sbjct: 1669 DDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT 1728
Query: 1229 DQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT 1288
++ +L + A + D K + ELR+ + + ++ +D ++ E+T+K+
Sbjct: 1729 NEISNMQKDLEHSNDALKAQDL-KIQEELRIAHMHLKEQ-QETIDKLRGIVSEKTDKLSN 1786
Query: 1289 MEQVTSLQN-KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
M++ N KLQ+K + L+ + + + + + ++ + +
Sbjct: 1787 MQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKL 1846
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
+L + ++ ++E ++ +E L++ + + +A+ LE+
Sbjct: 1847 EIENLNLAQKLHENLEEMK--SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI-- 1902
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
Q ELK + + K H+ T+ + +R+++ E +I D+ + + L+ K
Sbjct: 1903 QQELKTARMLSKEHKETV---------DKLREKISEKTIQISDIQKDLDKSKDELQ-KKQ 1952
Query: 1468 ENANHYETMQKESEIE-RVKLIEELNVKITESVSLNKQVAELNKALE 1513
+ NH +K + + L E L K + L K+ +E++ E
Sbjct: 1953 DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYE 1999
Score = 106 bits (254), Expect = 8e-22
Identities = 192/973 (19%), Positives = 428/973 (43%), Gaps = 72/973 (7%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXX 199
Q+ +V N +K+ ++ +E+ +L+L ++ E + I+ K
Sbjct: 1519 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV 1578
Query: 200 XXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKL 259
E+TK+ + KM+E+ E E++ K + + + K I L+E +
Sbjct: 1579 QEALQIERDQLKENTKEIVAKMKES---QEKEYQFLKMTAVNETQEKMCEIEHLKEQFET 1635
Query: 260 LEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCE-EKTEIEEKGSLEI 318
+ I E+ +L Q L + L +S+E + + E+ +++E I
Sbjct: 1636 QKLNLENIETENIRLTQILHENLEEMRSVTKERDDL--RSVEETLKVERDQLKENLRETI 1693
Query: 319 ANMTELTKKIELL-----EHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
E ++++++ EH ++R E N+++ M + + S+ + K L
Sbjct: 1694 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH-SNDALKAQDLKI 1752
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEK 431
++ R +K Q + + L +K +K ++ ++ +++ N L +K +
Sbjct: 1753 QEELRIAHMHLKE--QQETIDKLRGIVSEKTDK--LSNMQKDLENSNAKLQEKIQELKAN 1808
Query: 432 DTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELND 491
+ +++++ + ++ ++ SL E++N K+ E L +E+
Sbjct: 1809 EHQLITLKKDVNETQKKVSEME-QLKKQIKDQSLTLSKLEIENLNLAQKLHENL-EEMKS 1866
Query: 492 EIKDV-NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SK 549
+K+ N++ + E LK +Q+ + E A + + + ++ K+ ++T+D K
Sbjct: 1867 VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK 1926
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+S+ +I + ++L ++ ++K + Q H V + R++ SD + + E
Sbjct: 1927 ISEKTIQISDIQKDLDKSKDEL----QKKQDRQNHQVKPEK-RLL-SDGQQHLTESLREK 1980
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYD-EVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
+R+K + S+ D + L+ L + E+E + +++++ +++ H+E+
Sbjct: 1981 CSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLF 2040
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS 728
A E +++ LK + + ++ ++ + +NK + MD D++EK
Sbjct: 2041 TANQRCSMEFHRIMKKLKY----VLSYVTKIKEEQHESINKFE------MDFIDEVEKQK 2090
Query: 729 AEKISELLAKINHEEQS-KIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEESIA 786
ELL KI H +Q + ++ D K+ Q DL+IE I + S+ + + E
Sbjct: 2091 -----ELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ-Q 2144
Query: 787 VMEDRRYSLERKADQLGSYLQ-EK-----QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
V+ +R+ + + L + EK QK + NR+ +M+ E++
Sbjct: 2145 VLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEER 2204
Query: 841 LLEI----EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
I E + K L++KN+ L + Q L+ SL+ Q N + N+ S +T+
Sbjct: 2205 SATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ-VNPTTQD-NKNPHVTSRATQL 2262
Query: 897 QTQ-LRDLESNL---KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEK 952
T+ +R+LE++L K ++ I++ +KE+E + + ++++ + + EK ++
Sbjct: 2263 TTEKIRELENSLHEAKESAMHKESKIIKMQKELE-VTNDIIAKLQAKVHESNKCLEKTKE 2321
Query: 953 NIEYVTQLEAQ-LQEYKNNIENLNMNVE--ELNKM-NLELIDKHVQKQQTQSPDYTEQYI 1008
I+ + A + YK IE+L M + +L KM N + +K + + + +Y ++ I
Sbjct: 2322 TIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKA-TVEYQKEVI 2380
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
+ + N Q+ ++ +++ + Q S + S + Q TK ++ E R+
Sbjct: 2381 RLLRE-NLRRSQQAQDTSVISEH-TDPQPSNKPLTCGGGSGIVQ-NTKALILKSEHIRLE 2437
Query: 1069 KQLLDSKQHNEEL 1081
K++ KQ NE+L
Sbjct: 2438 KEISKLKQQNEQL 2450
Score = 82.6 bits (195), Expect = 1e-14
Identities = 166/855 (19%), Positives = 356/855 (41%), Gaps = 81/855 (9%)
Query: 750 QFGIDAKIQERDLYIENIESE---LSKYKSRICRLEESI--AVMEDRRYSLERKADQLGS 804
QF AK + Y+ + ++ L +Y+ I L++ + +E R ++E+ DQL
Sbjct: 326 QFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK--DQLAQ 383
Query: 805 YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
L+EK +Q +++ N +L+ + +Q L+ + + + +I +N N
Sbjct: 384 LLEEKDLLQK---VQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSN 440
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE 924
S++ + K + L E + + D+ SN E + K
Sbjct: 441 -YADQSNIPTNITTKTHKLSINLLREIDESVCSES--DVFSNTLDTLSEIEWNPATKLLN 497
Query: 925 IEDLEIEFNT---QIESAIRD-KKVLNEKYEKNIEY-----VTQLEAQLQEYKNNIEN-L 974
E++E E N+ ++ + D +++ EK E ++ + + EA ++ K + EN L
Sbjct: 498 QENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQENEL 557
Query: 975 NMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK--DEEIIALNQ 1030
+ VE L + ++ + +++ Q+ ++ Y E + +KQ D E +AL+
Sbjct: 558 SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDA 617
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
K +A + ++ + + K+ + T + ME ++Q QL K+ +L+ +E
Sbjct: 618 KRESAFLRSENL--ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLE---KELQS 672
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
E+ TKLT +G + + + + D ++EE
Sbjct: 673 AFNEI--TKLT-----SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 725
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ-----INQLKSKLEQ 1205
+ E L + +L E+Q+ ++ + + T + +VV++E + ++ +
Sbjct: 726 LSELKSLPSEVERLRKEIQD-KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDD 784
Query: 1206 LNTENDNLLSTVAELRSSISSAVD-QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
L T N ST E ++ + +D ++ +++ + + Q + K + L A
Sbjct: 785 LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL 844
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQV-TSLQNK---LQDKEEHLRNLQEKYADVINQI 1320
+++ +Q T+E ++ MEQ+ L+N+ LQ E + EK + ++
Sbjct: 845 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 904
Query: 1321 EILRSEIED----------EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQ-SIL- 1368
+ L E +D E+ LR +S KQ QE + L
Sbjct: 905 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 964
Query: 1369 -NINEE---NAQLKKSSXXXXXXXXXXXXRVN---DAEAKVLELTHQLELKDSEIYQKTH 1421
I+EE N +++++ ++ D EAK + T ++KD+EI ++
Sbjct: 965 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ-TLTADVKDNEIIEQQR 1023
Query: 1422 EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE 1481
+ + ++N+ + + + E E+ DL ++ E+ I EN + E +
Sbjct: 1024 KIFSLIQEKNELQQMLESVIAEKEQLKTDL--KENIEMTI------ENQEELRLLGDELK 1075
Query: 1482 IERVKLIEELNVKITESVSLNK---QVAELNKALEEEVAKTNEMQTALENQEIEIVTLND 1538
++ + +E N I + L++ ++AE+ + L+E+ + E Q L N + E+ +
Sbjct: 1076 KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK 1135
Query: 1539 EITNLQNMVRASSSK 1553
+I ++N+ +K
Sbjct: 1136 KINEIENLKNELKNK 1150
Score = 72.1 bits (169), Expect = 2e-11
Identities = 204/1035 (19%), Positives = 425/1035 (41%), Gaps = 122/1035 (11%)
Query: 168 METTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIA 227
+E L L EK E + I++ K E ++ + K+QE+
Sbjct: 1306 IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES--- 1362
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
+ K E+ +K+ +++ +I S E K ++A I +E L++ L++
Sbjct: 1363 ---QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKS 1419
Query: 288 XXXXXXXLAK-----QSIEPSCEEKTE------IEEKGSLEIANM-------------TE 323
L + QS +E + +E + L++A+
Sbjct: 1420 VAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1479
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTES-----KAVSSPSKKGSPLISRKSGRNT 378
L++K + + Q+ N +L+NK+ + + K +S +K + L K R
Sbjct: 1480 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1539
Query: 379 A-SKMKSPWSQLSSETLN-QDTDKKIN-----KNEIAKLEMVIQSLNKDLVD--KEYVIS 429
S ++S S++ T Q++ ++I K E+ +++ +Q L + KE V
Sbjct: 1540 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1599
Query: 430 EKDTXXXXXXXX--XXGKDTLIAQLQLEH-QQHMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
K++ +T ++EH ++ E L TE++ + E L+
Sbjct: 1600 MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE 1659
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQ-LNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
+ + + +++ + E LK +Q+ + L + I + ++K H + LK+ Q+TID
Sbjct: 1660 EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH-MHLKEHQETID 1718
Query: 546 NFSK-VSDSNKEIVRLTEELHH----LSQKVAELEEEKGNLQLHLVDY----DSGRMIES 596
VS+ EI + ++L H L + +++EE +HL + D R I S
Sbjct: 1719 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS 1778
Query: 597 DVYKKMIEME-NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--- 652
+ K+ M+ +L + K ++ K + +L L++ +E + K++++ QL+
Sbjct: 1779 EKTDKLSNMQKDLENSNAKLQEKIQELKAN-EHQLITLKKDVNETQKKVSEMEQLKKQIK 1837
Query: 653 DQVCS----EIKSVHL----EEQIDALSASKKE---LALVIENLKLDKEQLYGTIKDLEN 701
DQ + EI++++L E ++ + + KE L V E LKL+++QL ++++ +
Sbjct: 1838 DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1897
Query: 702 DKEDIMNKLQN---YIQENMDLTDKLEKMSAEK---ISELLAKINH--EEQSKIQTQFGI 753
+I +L+ +E+ + DKL + +EK IS++ ++ +E K Q +
Sbjct: 1898 RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNH 1957
Query: 754 DAKIQERDLYI--ENIESELSKYKSRICRLEESIAVMEDR-----RYSLE-RKADQLGSY 805
K ++R L +++ L + SRI L + + M+D R SL+ K +
Sbjct: 1958 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2017
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVL-----MDHDRVVEKQLLEIEHENKELQKKNQIL-- 858
L + KA + + + +L M+ R+++K + + K +++++ +
Sbjct: 2018 LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINK 2077
Query: 859 --------LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKR 909
+E+ + L I + +QQ + + L ++ + L+D ES
Sbjct: 2078 FEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPS 2137
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
I E Q ++ +K+ + LE NT+ + EK + I+ Q+ + N
Sbjct: 2138 IKTEFQQVLSNRKEMTQFLEEWLNTRFDI---------EKLKNGIQKENDRICQVNNFFN 2188
Query: 970 NIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
N MN + I K ++ + E+ L L ++
Sbjct: 2189 NRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS-GAQVNPTT 2247
Query: 1030 QKINNAQVSYMSM------VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
Q N V+ + + + E+ L + + E ++ ++ K+L + +LQ
Sbjct: 2248 QDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQA 2307
Query: 1084 LVREQDDQIKELKET 1098
V E + +++ KET
Sbjct: 2308 KVHESNKCLEKTKET 2322
Score = 55.2 bits (127), Expect = 2e-06
Identities = 148/709 (20%), Positives = 296/709 (41%), Gaps = 71/709 (10%)
Query: 320 NMTELTKKIELLEHLNCQIRQTNKELEN-KLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ E KK+ +E L QI+ + L ++ + K + + S + R + R
Sbjct: 1818 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRV 1877
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDK-EYVISEKDTXXXX 437
+K QL E+L + + + + K ++ +K+ VDK ISEK T
Sbjct: 1878 EETLKLERDQLK-ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK-TIQIS 1935
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPS--LIHVGTN--TEDVNE-IAKVQEQLKQ--ELN 490
K Q + + Q H P L+ G TE + E ++++E LK+ E++
Sbjct: 1936 DIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 1995
Query: 491 DEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKV 550
D + +N L L EI+ + ++VK+N L Q + F+
Sbjct: 1996 DHYECLNRLSL------------DLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN 2043
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAE 610
+ E R+ ++L ++ V +++EE+ + ++ + D +E + +I++++L +
Sbjct: 2044 QRCSMEFHRIMKKLKYVLSYVTKIKEEQ-HESINKFEMDFIDEVEKQ-KELLIKIQHLQQ 2101
Query: 611 TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA 670
L K + +LHI E+ L D S+ SE S+ E Q
Sbjct: 2102 DCDVPSRELRDLKLNQNMDLHI--------EEILKDFSE-------SEFPSIKTEFQ--Q 2144
Query: 671 LSASKKELALVIE---NLKLDKEQLYGTIKDLENDKE-DIMNKLQNYIQENMDLTDKLEK 726
+ +++KE+ +E N + D E+L I+ END+ + N N I M+ + + E+
Sbjct: 2145 VLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK-ENDRICQVNNFFNNRIIAIMNESTEFEE 2203
Query: 727 MSA------EKISELLAKINHEEQSKIQT-QFGIDAKIQERDLYIENIESELSKYKSRIC 779
SA E+ + L + N + QT + + + Q +N ++ +++
Sbjct: 2204 RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL- 2262
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
E I +E+ + + A S + + QK E + D + A + + ++ +EK
Sbjct: 2263 -TTEKIRELENSLHEAKESAMHKESKIIKMQK---ELEVTNDIIAKLQAKVHESNKCLEK 2318
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISL--SDMQQHYNALVEKANRTDLAESESTKYQ 897
I+ ++ + EE ++L++ L D+++ NA ++ + A + +YQ
Sbjct: 2319 TKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA--KEFEKEISATKATVEYQ 2376
Query: 898 TQ-LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAI-RDKKVL-----NEKY 950
+ +R L NL+R T ++ + + + S I ++ K L + +
Sbjct: 2377 KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRL 2436
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNV-EELNKMNLELIDKHVQKQQT 998
EK I + Q QL + KN + + N ++ E+ + + KQ T
Sbjct: 2437 EKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVT 2485
>Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein.
Length = 2663
Score = 157 bits (381), Expect = 3e-37
Identities = 269/1344 (20%), Positives = 582/1344 (43%), Gaps = 122/1344 (9%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT--E 355
Q +E K E+ + +I + E + LE++ + + + +E+ T +
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDS-QKLENIKMDLSYSLESIEDPKQMKQTLFD 629
Query: 356 SKAVSSPSKKGSPLISRKSGRNTASKMK---SPWSQLSSETLNQDTDKKINKNEIAKLEM 412
++ V+ +K+ S + R KMK + + Q+ ++ + + K LE
Sbjct: 630 AETVALDAKRESAFL-RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Query: 413 VIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME-GPSLIHVGTN 471
+QS ++ +I K GK I LQ E + +E +L
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK---ITDLQKELNKEVEENEALREEVIL 745
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNV----KD-LIEKLKSAEEQITQLNDEIDAANKNM 526
++ + E+L++E+ D+ +++++ KD L ++ E ++ L +EI ++
Sbjct: 746 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
Query: 527 IKVKSNHKLKLKQMQ--KTI--DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
+SN+K ++ Q KT+ D K +E R+ +E+ +LS++ + + G L+
Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
Query: 583 LHLVDYDSGRMIES--DVYKKMIEMENLAE---TRLKAISLLESQKFDLVQELHILQQKY 637
L Y + + E +V +++ EME L E R + +E +K + ++L ++
Sbjct: 866 TEL-SYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEV 924
Query: 638 DEVEDKLADISQLQSD-QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
+ + D+ QLQ Q+ + + + ++ ++++L +E+LK +E + T+
Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI-NTL 983
Query: 697 KDLENDK-------EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
K +++ E+ + ++ Q+ M DK + + A+ L A + E I+
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI--IEQ 1041
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q I + IQE++ + +ES +++ + L+E+I + + + L D+L +
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 810 QKAYSEYTIQEDEL---VNRLAVLMDH-----DRVVEKQ--LLEIEHENKELQKK-NQI- 857
+ + +E EL +RLA + + ++ EKQ LL ++ E E+QKK N+I
Sbjct: 1102 AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
Query: 858 -LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN-------LKR 909
L E +N +++L M+ L +K N TK + L++L+ + L+
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEK--NIEYVTQLEAQLQE- 966
E + +Q K+E++ I E+ ++ ++EK + N + + + +LQE
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 967 --YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL--NALLKQKD 1022
+ + L NV+++++ + + + +Q+ + D T E+ +L N ++
Sbjct: 1282 IPVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQ 1341
Query: 1023 EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
EEI +L ++ +N + ++ ++ L ++E + +Q L+ K+ + E
Sbjct: 1342 EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK-QEQSLNMKEKDNETT 1400
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
+V E + Q K L E+ E + +S ++ D+ +V
Sbjct: 1401 KIVSEME-QFKPKDSALLRIEI-----EMLGLSKRLQESHDEMKSV-------------- 1440
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ--INQLK 1200
+E+++ + + VLQ +S +L ++E K LET H + +++ IN+L+
Sbjct: 1441 -AKEKDDLQRLQEVLQSESDQLKENIKEIVAK--HLETEEELKVAHCCLKEQEETINELR 1497
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
L + TE +ST+ + +I+ + + EI E +Q ++ ++ Q+ +EL+ Q
Sbjct: 1498 VNLSEKETE----ISTIQKQLEAINDKLQNKIQEIYEKEEQLNIKQISEVQENVNELK-Q 1552
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ L S++S E TN++ E +Q +++KEE ++ +QE +Q+
Sbjct: 1553 FKEHRKAKDSALQSIESKMLELTNRL--QESQEEIQIMIKEKEE-MKRVQEALQIERDQL 1609
Query: 1321 -----EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
EI+ E ++ + ++ + + + Q+ ++ NI EN
Sbjct: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF-ETQKLNLENIETENI 1668
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
+L + +D + + L+++ ++ + E ++ +E +
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRS----VEETLKVERDQLKENLRETITRDLEKQEELK 1724
Query: 1436 NVRQQLVEYEKRIEDL---TYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN 1492
V L E+++ I+ L EK +E++ M ++ H K ++ K+ EEL
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEIS----NMQKDLEHSNDALKAQDL---KIQEELR 1777
Query: 1493 VKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI-TNLQNMV--RA 1549
+ + + +L + E+ K + MQ LEN ++ E+ N ++ +
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 1550 SSSKIQKHVSFASD-TKQGRDEQL 1572
++ QK VS KQ +D+ L
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSL 1861
Score = 140 bits (339), Expect = 4e-32
Identities = 239/1313 (18%), Positives = 573/1313 (43%), Gaps = 106/1313 (8%)
Query: 328 IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS 387
+E E +N +I +KE + +++G +S +++ + K+ R ++
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE----LQEKT-REVQERLNE-ME 890
Query: 388 QLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDT 447
QL + N+D+ + + E ++ + L + L + + + EKD +D
Sbjct: 891 QLKEQLENRDSPLQTVEREKT---LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 448 L------IAQLQLEHQQHMEGPSLIHVGTNTEDVNEI-AKVQEQLKQELNDEIKDVNVKD 500
L + ++ Q+ + +L + + E +N + +K+ E++ + L+ E KD
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRN-ALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
Query: 501 L-------IEKLKSAEEQITQL-------NDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
I+K + E + TQ N+ I+ K ++ ++L+ + ++ I
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ-QMLESVIAE 1065
Query: 547 FSKVSDSNKEIVRLT----EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM 602
++ KE + +T EEL L ++ + +E + H + + G + S ++
Sbjct: 1066 KEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE-GEL--SRTCDRL 1122
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED-------KLADISQLQSDQV 655
E+E + + + + + Q ++ +E+ +Q+K +E+E+ K + ++++++
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE----NDKEDIMNKLQ 711
K E++ +++ +K L + ++ + +++ L G I+++E KE++ K+
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL--KIA 1240
Query: 712 N-YIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESE 770
+ +++E+ + D+L + +EK +++ IN ++ K T K+QE ++ + + E E
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQI---INTQDLEKSHT------KLQE-EIPVLHEEQE 1290
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
L ++ +E++ +E K + ++ ++ +E + E + L
Sbjct: 1291 LLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Query: 831 MDHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQHYNA---LVEKANRT 886
D+ + + K+ LE++H+ KE ++ ++E+Q+ Q +M++ N +V + +
Sbjct: 1351 RDNLKTI-KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
Query: 887 DLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+S + + ++ L L+ +H+ + ++K +++ L+ ++ + + K +
Sbjct: 1410 KPKDSALLRIEIEMLGLSKRLQE-SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI 1468
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
K+ + E + L+E + I L +N+ E + + I K ++ + + ++
Sbjct: 1469 VAKHLETEEELKVAHCCLKEQEETINELRVNLSE-KETEISTIQKQLEAINDKLQNKIQE 1527
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ +LN + +E + ++ + + S + ESK+ + T +L+ +EE+Q
Sbjct: 1528 IYEKEEQLNIKQISEVQENVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKE-LKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
+ K+ + K+ E LQI + DQ+KE KE + + K + + + +
Sbjct: 1588 MIKEKEEMKRVQEALQI----ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
++ L+ E E I+ +L E ++ + +E ETL E
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETEN-IRLTQILHENLEEMRSVTKERDDLRSVEETLKVER 1702
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLS---TVAELRSSISSAVDQRGFEIAELWKQH 1242
+E I + K E+L + +L T+ +LR +S ++ +L +
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 1243 LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN-KLQD 1301
A + D K + ELR+ + + E + D ++ E+T+K+ M++ N KLQ+
Sbjct: 1763 DALKAQDL-KIQEELRIAHMHLKEQQETI-DKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
K + L+ + + + + + ++ + + +L + ++
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHEN 1880
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
++E ++ +E L++ + + +A+ LE+ Q ELK + + K H
Sbjct: 1881 LEEMK--SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI--QQELKTARMLSKEH 1936
Query: 1422 EYTI-----TLTQRNDEFENVRQQL----VEYEKRIEDLTYEKESELAILRLKMHENANH 1472
+ T+ ++++ + ++++ L E +K+I++L ++ EL +LR+K N +H
Sbjct: 1937 KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL---QKKELQLLRVKEDVNMSH 1993
Query: 1473 YETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
+K +E+E++K E N + + +L+++LEE E +E
Sbjct: 1994 ----KKINEMEQLKKQFEPNYLCKCEMDNFQLTKKLHESLEEIRIVAKERDELRRIKESL 2049
Query: 1533 IVTLNDEITNLQNMVR--ASSSKIQKHVSFASDTKQGRDEQLDNTMN--KELL 1581
+ + I L+ M+ + +++ SD +Q E L + KELL
Sbjct: 2050 KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLMESLREKCSRIKELL 2102
Score = 127 bits (306), Expect = 4e-28
Identities = 312/1561 (19%), Positives = 647/1561 (41%), Gaps = 162/1561 (10%)
Query: 105 MEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVL--Q 162
ME++K+ E ++ S V ++ +T + +K+ +L + Q
Sbjct: 889 MEQLKEQLE-NRDSPLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 163 VKMKIMETTIL--DLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTK 220
+K I +T + D QE++ + ++ + E+T + +
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 221 MQENFIAMEAEWKDEKQRLLKDIESKDVRISSLE-EANKLLEAARFEISLEHSKLAQELE 279
Q+ + + D+KQ D+E+K+ + + + + N+++E R SL K EL+
Sbjct: 1008 FQQKMVGI-----DKKQ----DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK--NELQ 1056
Query: 280 QXXXXXXXXXXXXXXLAKQSIEPSCEEKTEI-----EEKGSLEIANMT---------ELT 325
Q K++IE + E + E+ E K EI EL+
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+ + L + ++++ +++L+ K + + +S KK + + + K N +
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLK---NELKNKELT 1173
Query: 386 WSQLSSETLNQDTDKKINKN-----EIAKLEMVIQSLNKDL-VDKEYVISEKDTXXXXXX 439
+ +E L + +K+N+N I K V++ L K +++++ +
Sbjct: 1174 LEHMETERL--ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL---RGYIREIEA 1228
Query: 440 XXXXGKDTL-IAQLQL-EHQQHM-EGPSLIHVGT----NTEDVNEI-AKVQEQL-----K 486
K+ L IA + L EHQ+ + E + T NT+D+ + K+QE++ +
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE 1288
Query: 487 QELNDEIKDVN-VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
QEL +K V+ ++ + +L+ EQ T D A M +++ N K + + Q+ I
Sbjct: 1289 QELLPNVKKVSETQETMNELELLTEQSTT-KDSTTLARIEMERLRLNEKFQ--ESQEEIK 1345
Query: 546 NFSKVSDSNKEIVRLTEELH-----HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYK 600
+ +K D+ K I E H H+ + +A+++E + + L + + +++ K
Sbjct: 1346 SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL----NMKEKDNETTK 1401
Query: 601 KMIEMENLAETRLKAISLLESQKFDL---VQELHILQQKYDEVED---KLADISQLQSDQ 654
+ EME + + A+ +E + L +QE H + + +D +L ++ Q +SDQ
Sbjct: 1402 IVSEMEQF-KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460
Query: 655 VCSEIKSV---HLE--EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK 709
+ IK + HLE E++ KE I L+++ + I ++ E I +K
Sbjct: 1461 LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK 1520
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
LQN IQE + +K E+++ ++ISE+ +N +Q K + +D +++IES
Sbjct: 1521 LQNKIQE---IYEKEEQLNIKQISEVQENVNELKQFKEHRK--------AKDSALQSIES 1569
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
++ + +R+ +E I +M + ++R + L + ++ E + E +
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629
Query: 830 LMDHDRVVEKQ--LLEIEH--ENKELQKKNQILLE-ENQNLQISLSDMQQHYNALVEKAN 884
+ V E Q + EIEH E E QK N +E EN L L + + ++ ++
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE-- 1687
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
R DL E T + + L+ NL+ E T ++K++E++ + + E+ + +
Sbjct: 1688 RDDLRSVEET-LKVERDQLKENLR----ETITRDLEKQEELKIVHMHLKEHQETIDKLRG 1742
Query: 945 VLNEK------YEKNIEYVTQ-LEAQLQEYKNNIENLNMNVEE----LNKMNLELIDKHV 993
+++EK +K++E+ L+AQ + + + +M+++E ++K+ ++ +
Sbjct: 1743 IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR-GIVSEKT 1801
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ--VSYMSMVSDYESKLA 1051
K D K+ L K + ++I L + +N Q VS M + +
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQEL-KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
Query: 1052 QFTTKLE----NMEEEMQR---VSKQLLDSKQHNEELQILVREQDDQIKE-LKETK---L 1100
+KLE N+ +E+ K ++ + + ++ ++ + DQ+KE L+ETK L
Sbjct: 1861 LTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Query: 1101 TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE--EFIQERSVLQ 1158
+ + KT M+ E + + L ++E + IQE +
Sbjct: 1921 EIQQEL-KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKE 1979
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN-QLKSKLEQLNTENDNLLSTV 1217
Q ++ ++ + KI ++E L + + + E N QL KL + E +
Sbjct: 1980 LQLLRVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEMDNFQLTKKLHESLEEIRIVAKER 2039
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQS 1277
ELR S +R IA L + + R+ + + E R+ + E L + S
Sbjct: 2040 DELRRIKESLKMERDQFIATL--REMIARDRQNHQVKPEKRLLSDGQQHLMESLREKC-S 2096
Query: 1278 STQEETNKIVTMEQVTSLQNKLQ---DKEEHLRNLQEKYADVINQIEILR-------SEI 1327
+E + M+ N+L +KE + +K V++ + ++ ++
Sbjct: 2097 RIKELLKRYSEMDDHYECLNRLSLDLEKEIEFHRIMKKLKYVLSYVTKIKEEQHECINKF 2156
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
E + + D ++ + ++ ++++ E LK S
Sbjct: 2157 EMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI-LKDFSESEFPS 2215
Query: 1388 XXXXXXRV--NDAE-AKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN----VRQQ 1440
+V N E + LE ++ + + Q N+ F N + +
Sbjct: 2216 IKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2275
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE-SEIERVK--LIEELNVKITE 1497
E+E+R ++ E E +L L+ K + +Y+T++ + +V + N +T
Sbjct: 2276 STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2335
Query: 1498 SVS--LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ 1555
+ +++ EL +L E ++ + + E+ ND I LQ V S+ ++
Sbjct: 2336 RATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE 2395
Query: 1556 K 1556
K
Sbjct: 2396 K 2396
Score = 111 bits (267), Expect = 2e-23
Identities = 234/1125 (20%), Positives = 487/1125 (43%), Gaps = 131/1125 (11%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E+V+ + Q K +L +++ KDL++K+++ E+I L + ++ ++ +
Sbjct: 360 EEVSLETRAQAMEKDQLAQLLEE---KDLLQKVQN--EKIENLTRMLVTSSSLTLQQELK 414
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEI-----VRLTEELHHLS-QKVAELEEEK-GNLQLHL 585
K K +++ + +K+ +SN +T + H LS + E++E +
Sbjct: 415 AKRK-RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFS 473
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
D+ IE + K++ EN+ E+ L + L + +LV + L+ + +E+E KL
Sbjct: 474 NTLDTLSEIEWNPATKLLNQENI-ESELNS---LRADYDNLVLDYEQLRTEKEEMELKLK 529
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
+ + L + E Q+ ++ K L E D E + +L +KED
Sbjct: 530 EKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHREVYNQDLENELSSKVELLREKED 589
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF-----GIDAKIQER 760
+ KLQ YI + KLE + + +S L I +Q K QT F +DAK +
Sbjct: 590 QIKKLQEYID-----SQKLENIKMD-LSYSLESIEDPKQMK-QTLFDAETVALDAKRESA 642
Query: 761 DLYIENIE--SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
L EN+E ++ + + ++E I + + + LE K +E Q A++E T
Sbjct: 643 FLRSENLELKEKMKELATTYKQMENDIQLYQSQ---LEAKKKMQVDLEKELQSAFNEIT- 698
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENK--ELQKKNQILLEENQNLQ---ISLSDMQ 873
+L L+D +V + L +E E K +LQK+ +EEN+ L+ I LS+++
Sbjct: 699 -------KLTSLID-GKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELK 750
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEI 930
SE + + +++D L IT E L +V K+ ++ L
Sbjct: 751 S--------------LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796
Query: 931 EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELID 990
E +D + K+ + QE++ N + L+M+ E+ KM LE +
Sbjct: 797 EI-----GKTKDDLATTQSNYKSTD---------QEFQ-NFKTLHMDFEQKYKMVLEENE 841
Query: 991 KHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKL 1050
+ Q+ S + +++ + + L L K +E L +K Q ++ + + +L
Sbjct: 842 RMNQEIVNLSKE-AQKFDSSLGALKTELSYKTQE---LQEKTREVQ-ERLNEMEQLKEQL 896
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
+ L+ +E E ++++L +Q EE++ L +E+DD +K+L+E+ L E + K++
Sbjct: 897 ENRDSPLQTVEREKTLITEKL---QQTLEEVKTLTQEKDD-LKQLQES-LQIERDQLKSD 951
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ + N LK + EE + ++E + + E Q+
Sbjct: 952 IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEE-VSRNLHMEENTGETKDEFQQ 1010
Query: 1171 CYTKIIQ---LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
I + LE NT+ DV + E I Q + + +N+ + ++ S+ +
Sbjct: 1011 KMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE-----LQQMLESVIAE 1065
Query: 1228 VDQRGFEIAELWKQHLA-QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
+Q ++ E + + Q E E + + ++ A E + + S T + ++
Sbjct: 1066 KEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV 1125
Query: 1287 VTMEQVTSLQNKLQDKEEHLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXXXXXX 1343
E++ +LQ+K++ L N+QE+ +++ IN+IE L++E++++++
Sbjct: 1126 --EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE 1183
Query: 1344 XXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
+ N++Y++++ +I +E LK+ + + EA L
Sbjct: 1184 LA-------QKLNENYEEVK-----SITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 1404 ELTHQLELKDSEIYQKTHEYTI-----TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ ELK + I+ K H+ TI +++++ + N + + K E++ E +
Sbjct: 1232 QTKE--ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ 1289
Query: 1459 LAILRLK----MHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
+ +K E N E + ++S + + + + E + LN++ E + ++
Sbjct: 1290 ELLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEM---ERLRLNEKFQESQEEIKS 1346
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ + ++T E E++ L + I ++ S SK ++ ++
Sbjct: 1347 LTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN 1391
Score = 106 bits (255), Expect = 6e-22
Identities = 205/1020 (20%), Positives = 437/1020 (42%), Gaps = 108/1020 (10%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXX 199
Q+ +V N +K+ ++ +E+ +L+L ++ E + I+ K
Sbjct: 1539 QISEVQENVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV 1598
Query: 200 XXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKL 259
E+TK+ + KM+E+ E E++ K + + + K I L+E +
Sbjct: 1599 QEALQIERDQLKENTKEIVAKMKES---QEKEYQFLKMTAVNETQEKMCEIEHLKEQFET 1655
Query: 260 LEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLA---------KQSIEPSCEEKT-- 308
+ I E+ +L Q L + L + ++ + E
Sbjct: 1656 QKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR 1715
Query: 309 EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSP 368
++E++ L+I +M L + E ++ L + + E+ N + + A+ + K
Sbjct: 1716 DLEKQEELKIVHM-HLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Query: 369 LIS-----RKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQ-------- 415
+ K + T K++ S+ + + N D + N AKL+ IQ
Sbjct: 1775 ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLE---NSNAKLQEKIQELKANEHQ 1831
Query: 416 --SLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL-IAQLQLEHQQHM---EGPSLIHVG 469
+L KD+ + + +SE + L I L L + H E S++
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKER 1891
Query: 470 TNTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKL----KSAEEQITQLNDEIDAAN 523
N V E K++ +QLK+ L + + +D+ ++ ++ K +E + +L ++I
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951
Query: 524 KNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL 583
+ ++ + ++QK I K +++R+ E+++ +K+ E+E+ K +
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQK---KELQLLRVKEDVNMSHKKINEMEQLKKQFEP 2008
Query: 584 HLV---DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY--D 638
+ + + D+ ++ + +++ + E+ +A+ R + + ES K + Q + L++ D
Sbjct: 2009 NYLCKCEMDNFQLTKK-LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2067
Query: 639 EVEDKLADISQLQSD----------QVCSEIKSV-----HLEEQIDALSASKKELALVIE 683
++ +L SD + CS IK + +++ + L+ +L IE
Sbjct: 2068 RQNHQVKPEKRLLSDGQQHLMESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIE 2127
Query: 684 NLKLDKEQLY--GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH 741
++ K+ Y + ++ ++ + +NK + MD D++EK ELL KI H
Sbjct: 2128 FHRIMKKLKYVLSYVTKIKEEQHECINKFE------MDFIDEVEKQK-----ELLIKIQH 2176
Query: 742 EEQS-KIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
+Q + ++ D K+ Q DL+IE I + S+ + + E V+ +R+ +
Sbjct: 2177 LQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ-QVLSNRKEMTQFLE 2235
Query: 800 DQLGSYLQ-EK-----QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI----EHENK 849
+ L + EK QK + NR+ +M+ E++ I E + K
Sbjct: 2236 EWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLK 2295
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ-LRDLESNL- 907
L++KN+ L + Q L+ SL+ Q N + N+ S +T+ T+ +R+LE++L
Sbjct: 2296 SLKEKNEKLFKNYQTLKTSLASGAQ-VNPTTQD-NKNPHVTSRATQLTTEKIRELENSLH 2353
Query: 908 --KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ-L 964
K ++ I++ +KE+E + + ++++ + + EK ++ I+ + A
Sbjct: 2354 EAKESAMHKESKIIKMQKELE-VTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGA 2412
Query: 965 QEYKNNIENLNMNVE--ELNKM-NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+ YK IE+L M + +L KM N + +K + + + +Y ++ I + + N Q+
Sbjct: 2413 KPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKA-TVEYQKEVIRLLRE-NLRRSQQ 2470
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
++ +++ + Q S + S + Q TK ++ E R+ K++ KQ NE+L
Sbjct: 2471 AQDTSVISEH-TDPQPSNKPLTCGGGSGIVQ-NTKALILKSEHIRLEKEISKLKQQNEQL 2528
Score = 100 bits (240), Expect = 4e-20
Identities = 199/982 (20%), Positives = 409/982 (41%), Gaps = 91/982 (9%)
Query: 153 EKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXE 212
E + L V +K E TI +L+ ++EK+ I K E
Sbjct: 1474 ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE 1533
Query: 213 DTK-QQMTKMQENFIAMEA--EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISL 269
+Q++++QEN ++ E + K L+ IESK LE N+L E+ EI +
Sbjct: 1534 QLNIKQISEVQENVNELKQFKEHRKAKDSALQSIESK-----MLELTNRLQESQE-EIQI 1587
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS-LEIANMTELTKKI 328
+ +E E+ L + + E + K E++ L++ + E +K+
Sbjct: 1588 ----MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSG--RNTASKMKSPW 386
+EHL Q LEN + T + + + ++++ R+ +K
Sbjct: 1644 CEIEHLKEQFETQKLNLEN-IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER 1702
Query: 387 SQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDK-EYVISEKDTXXXXXXXXXXGK 445
QL E L + + + K E K+ + +++ +DK ++SEK
Sbjct: 1703 DQLK-ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN-----VKD 500
+ + L+ Q+ + + H+ E ++++ + + +L++ KD+ +++
Sbjct: 1762 NDALKAQDLKIQEELRIAHM-HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
I++LK+ E Q+ L +++ K KV +LK KQ++ SK+ N + L
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQK---KVSEMEQLK-KQIKDQSLTLSKLEIEN---LNL 1873
Query: 561 TEELHHLSQKVAELEEEKGNLQL--HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
+ELH +++ + +E+ NL+ + + ++ ES K ++E + LK +
Sbjct: 1874 AQELHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE--IQQELKTARM 1931
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
L + + V +L +++ +K IS +Q D S+ + L+++I L KKEL
Sbjct: 1932 LSKEHKETVDKLR------EKISEKTIQISDIQKDLDKSKDE---LQKKIQELQ--KKEL 1980
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIM-NKLQNYIQENMDLTDKLEKMSAEKISELLA 737
L+ +K D + I ++E K+ N L +N LT KL + S E+I ++A
Sbjct: 1981 QLL--RVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEMDNFQLTKKLHE-SLEEI-RIVA 2036
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K +E +I+ + ERD +I + +++ + E + + +++ +E
Sbjct: 2037 K-ERDELRRIKESLKM-----ERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLMES 2090
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHD----RVVEKQLLEIEHENKELQK 853
++ S ++E K YSE E +NRL++ ++ + R+++K + + K ++
Sbjct: 2091 LREKC-SRIKELLKRYSEMD-DHYECLNRLSLDLEKEIEFHRIMKKLKYVLSYVTKIKEE 2148
Query: 854 KNQIL----------LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL 903
+++ + +E+ + L I + +QQ + + L ++ + L+D
Sbjct: 2149 QHECINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDF 2208
Query: 904 -ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
ES I E Q ++ +K+ + LE NT+ + EK + I+
Sbjct: 2209 SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDI---------EKLKNGIQKENDRIC 2259
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
Q+ + NN MN + I K ++ + E+ L L
Sbjct: 2260 QVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS-G 2318
Query: 1023 EEIIALNQKINNAQVSYMSM------VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
++ Q N V+ + + + E+ L + + E ++ ++ K+L +
Sbjct: 2319 AQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTND 2378
Query: 1077 HNEELQILVREQDDQIKELKET 1098
+LQ V E + +++ KET
Sbjct: 2379 IIAKLQAKVHESNKCLEKTKET 2400
Score = 79.4 bits (187), Expect = 1e-13
Identities = 160/827 (19%), Positives = 346/827 (41%), Gaps = 75/827 (9%)
Query: 750 QFGIDAKIQERDLYIENIESE---LSKYKSRICRLEESI--AVMEDRRYSLERKADQLGS 804
QF AK + Y+ + ++ L +Y+ I L++ + +E R ++E+ DQL
Sbjct: 321 QFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK--DQLAQ 378
Query: 805 YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
L+EK +Q +++ N +L+ + +Q L+ + + + +I +N N
Sbjct: 379 LLEEKDLLQK---VQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSN 435
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE 924
++ + K + L E + + D+ SN E + K
Sbjct: 436 YADQF-NIPTNITTKTHKLSINLLREIDESVCSES--DVFSNTLDTLSEIEWNPATKLLN 492
Query: 925 IEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK- 983
E++E E N+ A D VL+ YE+ ++E +L+E KN+++ + K
Sbjct: 493 QENIESELNSL--RADYDNLVLD--YEQLRTEKEEMELKLKE-KNDLDEFEALERKTKKD 547
Query: 984 MNLELIDK--HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
++LI + +++ Y + NE++ LL++K+++I L + I++ ++ +
Sbjct: 548 QEMQLIHEISNLKNLVKHREVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIK 607
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
M Y + + +++ + + V+ LD+K+ + L+ E +++KEL T
Sbjct: 608 MDLSYSLESIEDPKQMKQTLFDAETVA---LDAKRESAFLRSENLELKEKMKELATTYKQ 664
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF---IQERSVLQ 1158
E +I + + + + D + + + ++ ++ +
Sbjct: 665 MENDIQLYQSQ-LEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKIT 723
Query: 1159 EQSAKLNTELQE---CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+ +LN E++E ++I L L + L +++I +L + +E D L S
Sbjct: 724 DLQKELNKEVEENEALREEVILLSELKS-LPSEVERLRKEIQDKSEELHIITSEKDKLFS 782
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHE---LRVQLSAFESKYEQLL 1272
V S + +++ G K LA +++++ T+ E + FE KY+ +L
Sbjct: 783 EVVHKESRVQGLLEEIG-----KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
Query: 1273 DSVQSSTQEETNKIVTMEQVTS----LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+ + QE N ++ S L+ +L K + L+ + + +N++E L+ ++E
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 1329 DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
+ L TE Q + + + +E LK+
Sbjct: 898 NRDSPLQTVEREKT---------LITEK---LQQTLEEVKTLTQEKDDLKQLQESLQIER 945
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
++D + + Q +L+++ K H+ TI T ++ E V + L E+
Sbjct: 946 DQLKSDIHDTVN--MNIDTQEQLRNALESLKQHQETIN-TLKSKISEEVSRNL-HMEENT 1001
Query: 1449 EDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL 1508
+ E + ++ + K A + +T+ ++++ ++IE+ KI SL ++ EL
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTL--TADVKDNEIIEQQR-KI---FSLIQEKNEL 1055
Query: 1509 NKALEEEVAKTNEMQT--------ALENQEIEIVTLNDEITNLQNMV 1547
+ LE +A+ +++T +ENQE E+ L DE+ Q +V
Sbjct: 1056 QQMLESVIAEKEQLKTDLKENIEMTIENQE-ELRLLGDELKKQQEIV 1101
Score = 53.6 bits (123), Expect = 6e-06
Identities = 172/851 (20%), Positives = 345/851 (40%), Gaps = 76/851 (8%)
Query: 62 ENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKELSKRSSTT 121
E +V +KEH++ +L G V + ++N K E + +K ++L +
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRG--IVSEKTNEISNMQKDLEHSNDALKA-QDLKIQEELR 1777
Query: 122 IVRXXXXXXXXXXXXXXXQLGDVTH-LSNTIKEKDNALSVLQVK---MKIMETTILDL-- 175
I + + T LSN K+ +N+ + LQ K +K E ++ L
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 176 -----QEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQE--NFIAM 228
Q+K++E +Q+ + + E+ ++ + M+E N +
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRV 1897
Query: 229 EAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQEL-EQXXXXXXX 287
E K E+ +L + ++ R +++ L+ AR +S EH + +L E+
Sbjct: 1898 EETLKLERDQLKESLQETKARDLEIQQE---LKTARM-LSKEHKETVDKLREKISEKTIQ 1953
Query: 288 XXXXXXXL--AKQSIEPSCEE--KTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK 343
L +K ++ +E K E++ E NM+ KKI +E L Q + N
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH--KKINEMEQLKKQF-EPNY 2010
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS---ETLNQDTDK 400
+ ++ K S + R R +K Q + E + +D
Sbjct: 2011 LCKCEMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQN 2070
Query: 401 KINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM 460
K E L Q L + L +K I E + L L+ E + H
Sbjct: 2071 HQVKPEKRLLSDGQQHLMESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFHR 2130
Query: 461 EGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEID 520
L +V ++ + K++E+ + +N +++ D +EK K +I L + D
Sbjct: 2131 IMKKLKYV------LSYVTKIKEEQHECINKF--EMDFIDEVEKQKELLIKIQHLQQDCD 2182
Query: 521 AANKNM--IKVKSNHKLKLKQMQKTIDN---------FSKVSDSNKEIVRLTEELHHLSQ 569
++ + +K+ N L ++++ K F +V + KE+ + EE +
Sbjct: 2183 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF 2242
Query: 570 KVAELEE--EKGNLQLHLVD-YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
+ +L+ +K N ++ V+ + + R+I + + E E + T K E L
Sbjct: 2243 DIEKLKNGIQKENDRICQVNNFFNNRIIA--IMNESTEFEERSATISKE---WEQDLKSL 2297
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK-KELALVIENL 685
++ L + Y ++ LA S Q + + K+ H+ + L+ K +EL +
Sbjct: 2298 KEKNEKLFKNYQTLKTSLA--SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEA 2355
Query: 686 KLDKEQLYGTIKDLENDKE---DIMNKLQNYIQEN---MDLTDKLEKMSAEKISELLAKI 739
K I ++ + E DI+ KLQ + E+ ++ T + ++ +K++ L AK
Sbjct: 2356 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVA-LGAKP 2414
Query: 740 NHEEQSKIQTQFGIDAKIQ-ERDLYIENIESELSKYKSRICRLEESIAVM-EDRRYSLER 797
EE ++ + KI E+ + E E+S K+ + +E I ++ E+ R S +
Sbjct: 2415 YKEEIEDLKMKL---VKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQA 2471
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELV--NRLAVLMDHDRV-VEKQLLEIEHENKELQKK 854
+ + S + Q + T + N A+++ + + +EK++ +++ +N++L K+
Sbjct: 2472 QDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQ 2531
Query: 855 NQILLEENQNL 865
LL NQ+L
Sbjct: 2532 KNELLSNNQHL 2542
>X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein.
Length = 2185
Score = 147 bits (356), Expect = 3e-34
Identities = 195/948 (20%), Positives = 409/948 (43%), Gaps = 73/948 (7%)
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM----------SA 729
LV + L+KEQL ++ +E K + L + +K+ S
Sbjct: 127 LVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSL 186
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+I+EL ++ ++Q+K Q DA ++E+D YI +++++S K R+ ++ V++
Sbjct: 187 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 246
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
LE +A+ +E ++ E +++ V L L + E L + +
Sbjct: 247 PLP-QLEPQAEVFTK--EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+++ +L E + LQ L + Q +EK DL +E TK TQLRD ++ +++
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQE----LEKIK--DLHMAEKTKLITQLRDAKNLIEQ 357
Query: 910 ITHEHQTLIVQKKKEI-EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+ + +I + K+++ E LE++ + R K++ + E + A +E +
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 969 NNIENLNMNVEELNKMNLELID--KHVQKQQTQSPDYTEQYINEI-NKLNALLKQKDEEI 1025
+ E K+ E+ + K ++K + +Q ++ + ++ ++K+ EE
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477
Query: 1026 IALNQKINNAQVS--YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
IA QK++ +++ + +++ +F +++ E+ Q ++ K+ E L +
Sbjct: 478 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
Query: 1084 ---------LVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
++ E ++++++L++ T+ I + E + S E + +
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSA----KLNTELQECYTKIIQL-----ETLNTEL 1185
+ V E+ + S+ +Q A KL Q+ T++ +L + T L
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 1186 TGHDVVNQEQINQLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
+++ Q I ++ K LE+L+ + L S +EL S + A + E++ L Q
Sbjct: 658 KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL-SEVLKARHKLEEELSVLKDQ--- 713
Query: 1245 QREADFQKTEHELRVQLSAFESKYEQLLDSV--QSSTQEETNKIVTMEQVTSLQNKLQDK 1302
K + EL ++ ++ ++Q +DS+ + + + +Q+ L+ L+++
Sbjct: 714 -----TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
++HL+ Q ++ + +I RSE E ++ + + + Q+
Sbjct: 769 DKHLKEHQAHVENL--EADIKRSEGELQQAS--AKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK--- 1419
Q Q +L++ E L K ++ + +V +L QLE ++SE+ QK
Sbjct: 825 Q-QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 1420 -THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
T Y L N E E +Q LVE E I + ++ E+ IL K+ + + +
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 1479 ESEIERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEIEIVTLN 1537
E E + K E+ K+ + K++ E L K L ++ AK ++ LEN +E+
Sbjct: 944 EYE-TKFKNQEKKMEKVKQKA---KEMQETLKKKLLDQEAK---LKKELENTALELSQKE 996
Query: 1538 DEI-TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAV 1584
+ + M +A+S+ I VS ++ + E L +EL D +
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Score = 139 bits (337), Expect = 7e-32
Identities = 267/1403 (19%), Positives = 597/1403 (42%), Gaps = 119/1403 (8%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
+++ T +++ I +A ++ ++ L+ ++ K + SL + AR ++ E S L
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIE--EKGSLEIANMTELTKKIELL 331
+ ++ +Q ++ +E + I+ EK + N EL LL
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL-----LL 765
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM-KSPWSQLS 390
+ + +++ +EN A + + S K S +S + +K + +QL
Sbjct: 766 KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
+ L+ +T++ + ++A++E + + +L + I +D + + +
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDVCTEL--DAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 451 QLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEE 510
Q+ + +G E +I +E + ++ + K ++ L +KL + E+
Sbjct: 884 LTQVYESKLEDG------NKEQEQTKQILVEKENMILQMREGQKK-EIEILTQKLSAKED 936
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
I LN+E + KN K K K K+MQ+T+ K+ D +L +EL + + +
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK--KLLDQE---AKLKKELENTALE 991
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
+++ E++ L + +S + SD ++ E + +++ SL E + +L +
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGI--SDAVSRL---ETNQKEQIE--SLTEVHRRELNDVI 1044
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
I ++K ++ ++L +I ++Q + E+ L+++I K+E+ I LK +
Sbjct: 1045 SIWEKKLNQQAEELQEIHEIQLQEKEQEV--AELKQKILLFGCEKEEMNKEITWLKEEGV 1102
Query: 691 QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ 750
+ T+ +L+ + + + Q+ L LEK+ + L +EQ
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ--- 807
+ K + +L +++ +++S E+S +ED+ ++ +++L L
Sbjct: 1163 LAEEDKRKVSEL-TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
+K +A E + +EL+N + + ++ +H ++ K +L++
Sbjct: 1222 KKTEALLE--AKTNELIN---ISSSKTNAILSRISHCQHRTTKV--KEALLIKT-----C 1269
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
++S+++ L E+ N +++ ++T QL + E+ +K + + ++L+ +K E
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATH---QLEEKENQIKSMKADIESLVTEK----EA 1322
Query: 928 LEIEFNTQIESAIRDKKV---LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM 984
L+ E Q ++A + L ++ +NI VT ++ +L+E K I +L+ + +LN
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
I + +++ +QY E +L ++ ++ L+++ ++S + V
Sbjct: 1383 LQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKE----KISALEQVD 1436
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL-VREQDDQIKELKETKLTFE 1103
D+ +K +++ K ++ + Q K+L Q EL+ E+D+QI LKE
Sbjct: 1437 DWSNKFSEWKKKAQSRFTQHQNTVKEL----QIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK 1163
+G + + M +N++ ++ E E+ I ++++ E
Sbjct: 1493 KRFDCLKGEMEDDKSK-MEKKESNLETELKSQTA-----RIMELEDHITQKTIEIES--- 1543
Query: 1164 LNTELQEC-YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
LN L+ K I+ + L +L + +E+ N++K E++ T + + S AEL +
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603
Query: 1223 S------ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
++ +V + E+ L + ++ A + + + +++A + +QLL ++
Sbjct: 1604 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK---KQLLSQME 1660
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV-INQIEILRSEIEDEKV-AF 1334
+EE K T ++ L KLQ++E + L+EK V +Q E L + V A+
Sbjct: 1661 E--KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL-NINEENAQLKKSSXXXXXXXXXXXX 1393
+ + +++ +L + +E + S
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI 1778
Query: 1394 RVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE----------------FENV 1437
++ AEAK E + E+ +K +Y++ + Q ++ F++V
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDV 1838
Query: 1438 RQQLVE-------YEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
++ L E E++I++L + + R++M E + YE +Q +++ E
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L + TE S + V K L A+ N+++ L E E L EI LQ +R
Sbjct: 1899 LLEENTEEKSKSHLVQP--KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 1551 SSKIQKHVS-FASDTKQGRDEQL 1572
+ Q+ + + Q R+E++
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKI 1979
Score = 132 bits (319), Expect = 1e-29
Identities = 217/1121 (19%), Positives = 473/1121 (42%), Gaps = 88/1121 (7%)
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
++L +N + LI++L+ E ++ + ++ + +++ ++ +K
Sbjct: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYS-------ELVTAYQMLQREKKKLQGI 177
Query: 547 FSKVSDSN-KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM 605
S+ D + + I L EEL Q L+EE Y S + + K+ +
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ LK + LE Q +E + VED + + L++ Q + + L+
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTS-VKTLETLQQRVKRQENLLK 296
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTD 722
+ + + K++ L+ + +EQL +++LE K+ M KL +++ +L +
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIE 356
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK-YKSRICRL 781
+LE+ I+E +++ + K + + ++I++ E + + K ++ L
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 782 EESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEK 839
E++++ + + + ++ ++ +K E I + ++R+ V+ + E+
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 840 QLLEIE--HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
Q+ +++ HE KEL +K Q E + LQ + Q+ +EK+ L S+ + Q
Sbjct: 477 QIAKLQKLHE-KELARKEQ---ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
L L+ + + + ++ + + ++ DL+ E T + + L + ++N
Sbjct: 533 ESLA-----LEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPD-YTEQYINEINKLNA 1016
L L+ KN + E +K LE + T+ +QY E+ KL
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+Q+ E ++ + I A + M+ KL T+LE++ E+ V K +
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMN--EKTLEKLDVKQTELESLSSELSEVLKA---RHK 702
Query: 1077 HNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
EEL +L ++Q D++K+ E K+ + N + + + S I+ +
Sbjct: 703 LEEELSVL-KDQTDKMKQELEAKMDEQKNHHQQQ---VDSIIKEHEVSIQRTEKALKDQI 758
Query: 1137 XXXXXLKVQEEEEFIQERSV----LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L ++E ++ ++E L+ + ELQ+ K+ ++ +
Sbjct: 759 NQLELL-LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAY 817
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAEL---RSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+EQ+ QL+ KL L TE L VAE+ + + + +D ++ +L +Q
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ-------- 869
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
+K E+ ++ + YE L+ + QE+T +I+ ++ LQ + K+E + L
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLED-GNKEQEQTKQILVEKENMILQMREGQKKE-IEIL 927
Query: 1310 QEKYADVINQIEILRSEIE----DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQ 1365
+K + + I IL E E +++ L + K+ E
Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN 987
Query: 1366 SILNINEE----NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE-LT--HQLELKD----- 1413
+ L ++++ NA++ + + R+ + + +E LT H+ EL D
Sbjct: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047
Query: 1414 -SEIYQKTHE----YTITLTQRNDEFENVRQQLV----EYEKRIEDLTYEKE------SE 1458
++ Q+ E + I L ++ E ++Q+++ E E+ +++T+ KE +
Sbjct: 1048 EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 1459 LAILRLKMHENANHYETM-QKESEIER--VKLIEELNVKITESVSLNKQVAELNKALEEE 1515
L L+ ++ + + H ++ Q E++++ KL +LN + E+ L +Q+ EL EE+
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
K +E+ + L+ + E +L + S + +K
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Score = 128 bits (310), Expect = 1e-28
Identities = 258/1473 (17%), Positives = 618/1473 (41%), Gaps = 139/1473 (9%)
Query: 150 TIKEKDNALSVLQVKMKIMETTI------LDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+++EKD +SVLQ ++ +++ + +D+ + + + + E K
Sbjct: 213 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T QQ K QEN + E + K++ K+ L+E + LE
Sbjct: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ E +KL +L AK IE + E ++KG +
Sbjct: 333 IKDLHMAEKTKLITQLRD---------------AKNLIE-----QLE-QDKGMVIAETKR 371
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + +E+ E Q+R K++ T G E + S++ + + +TA K
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQM----TTQGEELREQKEKSERAA-FEELEKALSTAQKT 426
Query: 383 KSPWSQLSSETLNQ-DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+ +L +E Q T +K ++ E L+ + + +++VD SE+
Sbjct: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ--------- 477
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
IA+LQ H++ + E+ K + ++E +++K K
Sbjct: 478 -------IAKLQKLHEKEL-----------ARKEQELTKKLQTREREFQEQMKVALEKSQ 519
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRL 560
E LK ++E+ Q + ++ + + + KL+ +Q+ + + +++ + + +
Sbjct: 520 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKS 579
Query: 561 TEELHHLSQKVA---ELEEEKGNLQL------HLVDYDSGRMIESDVYKKMIE-MENLAE 610
+E + S+ +A E E+ K N ++ H + +S + + ++ + ++ ++ +
Sbjct: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 611 TRLKAI-SLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
T ++ + E +K L+++ I+ Q + +E+ +K + +L Q E S L E +
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT--LEKLDVKQTELESLSSELSEVL 697
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS 728
A ++EL+++ + K++L + + +N + ++ + + ++ T+K K
Sbjct: 698 KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757
Query: 729 AEKISELLAKINHEEQSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
++ ELL K + + Q ++A I+ + ++ ++L ++S E
Sbjct: 758 INQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKA 816
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E++ L++K L + K +E Q+ ++ L H V+ + ++E +
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA---HKIQVQDLMQQLEKQ 873
Query: 848 NKELQKKNQILLEENQN-LQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDL-- 903
N E+++K + L + ++ L+ + +Q LVEK N + E + + + + L
Sbjct: 874 NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSA 933
Query: 904 -ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNIEYVTQL 960
E ++ + E++T ++K++E ++ + E+ KK+L++ K +K +E T L
Sbjct: 934 KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL--KKKLLDQEAKLKKELEN-TAL 990
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNL-ELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +E + N + L M + N + + + + Q+ Q TE + E+N + ++ +
Sbjct: 991 ELSQKEKQFNAKMLEM--AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 1020 QKDEEIIALNQKINNAQVSYMSM-VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+K + Q+I+ Q+ V++ + K+ F + E M +E+ + ++ +
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
ELQ ++++ + L + + + ++ K E + S E V+
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Query: 1139 XXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQEQI 1196
++ + + E L+ K N L++ K ++ + L+ EL D+ ++
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLED---KSLEFKKLSEELAIQLDICCKKTE 1225
Query: 1197 NQLKSKLEQL----NTENDNLLSTVAELR---SSISSAVDQRGFEIAELWKQ--HLAQRE 1247
L++K +L +++ + +LS ++ + + + A+ + ++EL Q L + +
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
+ + QL E++ + + ++S T K ++ + Q +KE +
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLV---TEKEALQKEGGNQQQAASEKESCIT 1342
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
L+++ ++ IN + +++ E++++KV +++ +N +E +I
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL------NVQLQNSISLSEKEAAI 1396
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
++ ++ + K ++ + LE K SE +K
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQS---RF 1453
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
TQ + + ++ QL K YEK+ ++ +L+ ++ + ++ ++ E E ++ K+
Sbjct: 1454 TQHQNTVKELQIQLELKSKE----AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
K+ + L L+ + A+ E++ + + IEI +LN+ + N
Sbjct: 1510 --------------EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
++ + + + + +D ++ K L
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Score = 113 bits (271), Expect = 7e-24
Identities = 172/874 (19%), Positives = 392/874 (44%), Gaps = 76/874 (8%)
Query: 246 KDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCE 305
K +S LE + L + +++ + +LE+ L + E +
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK-EALQK 1325
Query: 306 EKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK 365
E ++ S + + +T+L K EL E++N + +EL+ K + + SK ++ + +
Sbjct: 1326 EGGNQQQAASEKESCITQLKK--ELSENINA-VTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 366 GSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKE 425
IS S ++ + + E L+Q D + ++K E + D +
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK-EKISALEQVDDWSNK 1441
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+ +K K+ I QL+L+ ++ E I++ E++++ K + L
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQI-QLELKSKEAYEKDEQINL--LKEELDQQNKRFDCL 1498
Query: 486 KQELNDEIKDVNVKD--LIEKLKSA-------EEQITQLNDEIDAANKNMIKVKSNHKLK 536
K E+ D+ + K+ L +LKS E+ ITQ EI++ N+ + ++
Sbjct: 1499 KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 537 LKQMQKTIDNFSKVSDSNKEIVRLTEE-LHHLSQKV----AELEEEKGNLQLHLVDYDSG 591
K++ + + +F ++ + V+ EE + L +V AELE +K L+ H+
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE-HVNLSVKS 1617
Query: 592 RMIESDVYKKMIEMEN---LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ E + +E E+ LAE + KA + + K L+ ++ +++Y + + + +S
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE--SHLS 1675
Query: 649 QLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+L + ++ + VH LEE++ ++ +S+ E +V + K E ++ D
Sbjct: 1676 ELNT-KLQEREREVHILEEKLKSVESSQSETLIVPRSAK-------NVAAYTEQEEADSQ 1727
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+Q +E + + L++ EK +LL ++ E++ + + F + + QER + +E+
Sbjct: 1728 GCVQKTYEEKISV---LQRNLTEK-EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E++ + +S I L+E + ++++YSL Q +K + IQ + N
Sbjct: 1784 EAKQHEDQSMIGHLQEELE-EKNKKYSL--------IVAQHVEKEGGKNNIQAKQ--NLE 1832
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
V D + ++++ L + +++++ + L+ + + ++ + ++ Y L
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL------QA 1886
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + + T+L + + K +H Q ++ E + ++EF ++ A R+K+ L
Sbjct: 1887 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLL-SNMEAQHNDLEF--KLAGAEREKQKLG 1943
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
++ + L +E++ +E L ++ E +K Q+Q+ +
Sbjct: 1944 KEI---VRLQKDLRMLRKEHQQELEILKKEYDQ------EREEKIKQEQEDLELKHNSTL 1994
Query: 1008 INEINKLNALLKQKDEEI-IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ + N L QK++E+ + + + IN AQ ++ ++ + Q K+ +++++R
Sbjct: 1995 KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR 2054
Query: 1067 VSK---QLLDSKQHNEELQILVREQDDQIKELKE 1097
+K ++LD+++ EE+ VR+ Q++EL++
Sbjct: 2055 TAKRYEEILDARE--EEMTAKVRDLQTQLEELQK 2086
Score = 46.0 bits (104), Expect = 0.001
Identities = 109/596 (18%), Positives = 243/596 (40%), Gaps = 65/596 (10%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
H +EKDN + + K+ +E + ++ ++ K + +E N +
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRI-----SSLEEANKLL 260
++ + E IA K++LL +E K+ + S L E N L
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAA------IKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 261 EAARFEISLEHSKL----AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSL 316
+ E+ + KL + + E +++ C +KT EEK S+
Sbjct: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT-YEEKISV 1740
Query: 317 EIANMTELTKKIE---------LLEH--LNCQIRQTNKELENKLA-------TMGTESKA 358
N+TE K ++ + H + CQ ++ +LE+ A +G +
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 359 VSSPSKKGSPLIS----RKSGRN---TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLE 411
+ +KK S +++ ++ G+N +++ + + ++ +I + +I +L+
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD 1860
Query: 412 -MVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH--QQHMEGPSLI-H 467
+++ V+ E + S+ + K T + + E + H+ P L+ +
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN 1920
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ D+ E+ KQ+L EI + KDL K ++++ L E D + I
Sbjct: 1921 MEAQHNDLEFKLAGAEREKQKLGKEIVRLQ-KDLRMLRKEHQQELEILKKEYDQEREEKI 1979
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH-HLSQKVAELEEEKGNLQLHLV 586
K + L+LK T+ + + N ++ + +EL + + + + +E + L
Sbjct: 1980 K-QEQEDLELKH-NSTLKQLMR--EFNTQLAQKEQELEMTIKETINKAQEVEAEL----- 2030
Query: 587 DYDSGRMIESDVYKKMIEM-ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+S + + + KK+ E ++L T + +L++++ ++ ++ LQ + +E++ K
Sbjct: 2031 -LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 2089
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + + + + L+ Q+ A K L I + KL +++ I +LE+
Sbjct: 2090 QKLEQEENPGNDNVTIMELQTQL----AQKTTL---ISDSKLKEQEFREQIHNLED 2138
>U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein.
Length = 2230
Score = 147 bits (356), Expect = 3e-34
Identities = 195/948 (20%), Positives = 409/948 (43%), Gaps = 73/948 (7%)
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM----------SA 729
LV + L+KEQL ++ +E K + L + +K+ S
Sbjct: 127 LVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSL 186
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+I+EL ++ ++Q+K Q DA ++E+D YI +++++S K R+ ++ V++
Sbjct: 187 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 246
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
LE +A+ +E ++ E +++ V L L + E L + +
Sbjct: 247 PLP-QLEPQAEVFTK--EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+++ +L E + LQ L + Q +EK DL +E TK TQLRD ++ +++
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQE----LEKIK--DLHMAEKTKLITQLRDAKNLIEQ 357
Query: 910 ITHEHQTLIVQKKKEI-EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+ + +I + K+++ E LE++ + R K++ + E + A +E +
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 969 NNIENLNMNVEELNKMNLELID--KHVQKQQTQSPDYTEQYINEI-NKLNALLKQKDEEI 1025
+ E K+ E+ + K ++K + +Q ++ + ++ ++K+ EE
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477
Query: 1026 IALNQKINNAQVS--YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
IA QK++ +++ + +++ +F +++ E+ Q ++ K+ E L +
Sbjct: 478 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
Query: 1084 ---------LVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
++ E ++++++L++ T+ I + E + S E + +
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSA----KLNTELQECYTKIIQL-----ETLNTEL 1185
+ V E+ + S+ +Q A KL Q+ T++ +L + T L
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 1186 TGHDVVNQEQINQLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
+++ Q I ++ K LE+L+ + L S +EL S + A + E++ L Q
Sbjct: 658 KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL-SEVLKARHKLEEELSVLKDQ--- 713
Query: 1245 QREADFQKTEHELRVQLSAFESKYEQLLDSV--QSSTQEETNKIVTMEQVTSLQNKLQDK 1302
K + EL ++ ++ ++Q +DS+ + + + +Q+ L+ L+++
Sbjct: 714 -----TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
++HL+ Q ++ + +I RSE E ++ + + + Q+
Sbjct: 769 DKHLKEHQAHVENL--EADIKRSEGELQQAS--AKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK--- 1419
Q Q +L++ E L K ++ + +V +L QLE ++SE+ QK
Sbjct: 825 Q-QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 1420 -THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
T Y L N E E +Q LVE E I + ++ E+ IL K+ + + +
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 1479 ESEIERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEIEIVTLN 1537
E E + K E+ K+ + K++ E L K L ++ AK ++ LEN +E+
Sbjct: 944 EYE-TKFKNQEKKMEKVKQKA---KEMQETLKKKLLDQEAK---LKKELENTALELSQKE 996
Query: 1538 DEI-TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAV 1584
+ + M +A+S+ I VS ++ + E L +EL D +
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Score = 139 bits (337), Expect = 7e-32
Identities = 267/1403 (19%), Positives = 597/1403 (42%), Gaps = 119/1403 (8%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
+++ T +++ I +A ++ ++ L+ ++ K + SL + AR ++ E S L
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIE--EKGSLEIANMTELTKKIELL 331
+ ++ +Q ++ +E + I+ EK + N EL LL
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL-----LL 765
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM-KSPWSQLS 390
+ + +++ +EN A + + S K S +S + +K + +QL
Sbjct: 766 KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
+ L+ +T++ + ++A++E + + +L + I +D + + +
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDVCTEL--DAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 451 QLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEE 510
Q+ + +G E +I +E + ++ + K ++ L +KL + E+
Sbjct: 884 LTQVYESKLEDG------NKEQEQTKQILVEKENMILQMREGQKK-EIEILTQKLSAKED 936
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
I LN+E + KN K K K K+MQ+T+ K+ D +L +EL + + +
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK--KLLDQE---AKLKKELENTALE 991
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
+++ E++ L + +S + SD ++ E + +++ SL E + +L +
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGI--SDAVSRL---ETNQKEQIE--SLTEVHRRELNDVI 1044
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
I ++K ++ ++L +I ++Q + E+ L+++I K+E+ I LK +
Sbjct: 1045 SIWEKKLNQQAEELQEIHEIQLQEKEQEV--AELKQKILLFGCEKEEMNKEITWLKEEGV 1102
Query: 691 QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ 750
+ T+ +L+ + + + Q+ L LEK+ + L +EQ
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ--- 807
+ K + +L +++ +++S E+S +ED+ ++ +++L L
Sbjct: 1163 LAEEDKRKVSEL-TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
+K +A E + +EL+N + + ++ +H ++ K +L++
Sbjct: 1222 KKTEALLE--AKTNELIN---ISSSKTNAILSRISHCQHRTTKV--KEALLIKT-----C 1269
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
++S+++ L E+ N +++ ++T QL + E+ +K + + ++L+ +K E
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATH---QLEEKENQIKSMKADIESLVTEK----EA 1322
Query: 928 LEIEFNTQIESAIRDKKV---LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM 984
L+ E Q ++A + L ++ +NI VT ++ +L+E K I +L+ + +LN
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
I + +++ +QY E +L ++ ++ L+++ ++S + V
Sbjct: 1383 LQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKE----KISALEQVD 1436
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL-VREQDDQIKELKETKLTFE 1103
D+ +K +++ K ++ + Q K+L Q EL+ E+D+QI LKE
Sbjct: 1437 DWSNKFSEWKKKAQSRFTQHQNTVKEL----QIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK 1163
+G + + M +N++ ++ E E+ I ++++ E
Sbjct: 1493 KRFDCLKGEMEDDKSK-MEKKESNLETELKSQTA-----RIMELEDHITQKTIEIES--- 1543
Query: 1164 LNTELQEC-YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
LN L+ K I+ + L +L + +E+ N++K E++ T + + S AEL +
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603
Query: 1223 S------ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
++ +V + E+ L + ++ A + + + +++A + +QLL ++
Sbjct: 1604 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK---KQLLSQME 1660
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV-INQIEILRSEIEDEKV-AF 1334
+EE K T ++ L KLQ++E + L+EK V +Q E L + V A+
Sbjct: 1661 E--KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL-NINEENAQLKKSSXXXXXXXXXXXX 1393
+ + +++ +L + +E + S
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI 1778
Query: 1394 RVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE----------------FENV 1437
++ AEAK E + E+ +K +Y++ + Q ++ F++V
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDV 1838
Query: 1438 RQQLVE-------YEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
++ L E E++I++L + + R++M E + YE +Q +++ E
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L + TE S + V K L A+ N+++ L E E L EI LQ +R
Sbjct: 1899 LLEENTEEKSKSHLVQP--KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 1551 SSKIQKHVS-FASDTKQGRDEQL 1572
+ Q+ + + Q R+E++
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKI 1979
Score = 132 bits (319), Expect = 1e-29
Identities = 217/1121 (19%), Positives = 473/1121 (42%), Gaps = 88/1121 (7%)
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
++L +N + LI++L+ E ++ + ++ + +++ ++ +K
Sbjct: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYS-------ELVTAYQMLQREKKKLQGI 177
Query: 547 FSKVSDSN-KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM 605
S+ D + + I L EEL Q L+EE Y S + + K+ +
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ LK + LE Q +E + VED + + L++ Q + + L+
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTS-VKTLETLQQRVKRQENLLK 296
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTD 722
+ + + K++ L+ + +EQL +++LE K+ M KL +++ +L +
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIE 356
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK-YKSRICRL 781
+LE+ I+E +++ + K + + ++I++ E + + K ++ L
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 782 EESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEK 839
E++++ + + + ++ ++ +K E I + ++R+ V+ + E+
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 840 QLLEIE--HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
Q+ +++ HE KEL +K Q E + LQ + Q+ +EK+ L S+ + Q
Sbjct: 477 QIAKLQKLHE-KELARKEQ---ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
L L+ + + + ++ + + ++ DL+ E T + + L + ++N
Sbjct: 533 ESLA-----LEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPD-YTEQYINEINKLNA 1016
L L+ KN + E +K LE + T+ +QY E+ KL
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+Q+ E ++ + I A + M+ KL T+LE++ E+ V K +
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMN--EKTLEKLDVKQTELESLSSELSEVLKA---RHK 702
Query: 1077 HNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
EEL +L ++Q D++K+ E K+ + N + + + S I+ +
Sbjct: 703 LEEELSVL-KDQTDKMKQELEAKMDEQKNHHQQQ---VDSIIKEHEVSIQRTEKALKDQI 758
Query: 1137 XXXXXLKVQEEEEFIQERSV----LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L ++E ++ ++E L+ + ELQ+ K+ ++ +
Sbjct: 759 NQLELL-LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAY 817
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAEL---RSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+EQ+ QL+ KL L TE L VAE+ + + + +D ++ +L +Q
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ-------- 869
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
+K E+ ++ + YE L+ + QE+T +I+ ++ LQ + K+E + L
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLED-GNKEQEQTKQILVEKENMILQMREGQKKE-IEIL 927
Query: 1310 QEKYADVINQIEILRSEIE----DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQ 1365
+K + + I IL E E +++ L + K+ E
Sbjct: 928 TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN 987
Query: 1366 SILNINEE----NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE-LT--HQLELKD----- 1413
+ L ++++ NA++ + + R+ + + +E LT H+ EL D
Sbjct: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047
Query: 1414 -SEIYQKTHE----YTITLTQRNDEFENVRQQLV----EYEKRIEDLTYEKE------SE 1458
++ Q+ E + I L ++ E ++Q+++ E E+ +++T+ KE +
Sbjct: 1048 EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 1459 LAILRLKMHENANHYETM-QKESEIER--VKLIEELNVKITESVSLNKQVAELNKALEEE 1515
L L+ ++ + + H ++ Q E++++ KL +LN + E+ L +Q+ EL EE+
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
K +E+ + L+ + E +L + S + +K
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Score = 128 bits (310), Expect = 1e-28
Identities = 258/1473 (17%), Positives = 618/1473 (41%), Gaps = 139/1473 (9%)
Query: 150 TIKEKDNALSVLQVKMKIMETTI------LDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+++EKD +SVLQ ++ +++ + +D+ + + + + E K
Sbjct: 213 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T QQ K QEN + E + K++ K+ L+E + LE
Sbjct: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ E +KL +L AK IE + E ++KG +
Sbjct: 333 IKDLHMAEKTKLITQLRD---------------AKNLIE-----QLE-QDKGMVIAETKR 371
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + +E+ E Q+R K++ T G E + S++ + + +TA K
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQM----TTQGEELREQKEKSERAA-FEELEKALSTAQKT 426
Query: 383 KSPWSQLSSETLNQ-DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+ +L +E Q T +K ++ E L+ + + +++VD SE+
Sbjct: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ--------- 477
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
IA+LQ H++ + E+ K + ++E +++K K
Sbjct: 478 -------IAKLQKLHEKEL-----------ARKEQELTKKLQTREREFQEQMKVALEKSQ 519
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRL 560
E LK ++E+ Q + ++ + + + KL+ +Q+ + + +++ + + +
Sbjct: 520 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKS 579
Query: 561 TEELHHLSQKVA---ELEEEKGNLQL------HLVDYDSGRMIESDVYKKMIE-MENLAE 610
+E + S+ +A E E+ K N ++ H + +S + + ++ + ++ ++ +
Sbjct: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 611 TRLKAI-SLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
T ++ + E +K L+++ I+ Q + +E+ +K + +L Q E S L E +
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT--LEKLDVKQTELESLSSELSEVL 697
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS 728
A ++EL+++ + K++L + + +N + ++ + + ++ T+K K
Sbjct: 698 KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757
Query: 729 AEKISELLAKINHEEQSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
++ ELL K + + Q ++A I+ + ++ ++L ++S E
Sbjct: 758 INQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKA 816
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E++ L++K L + K +E Q+ ++ L H V+ + ++E +
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA---HKIQVQDLMQQLEKQ 873
Query: 848 NKELQKKNQILLEENQN-LQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDL-- 903
N E+++K + L + ++ L+ + +Q LVEK N + E + + + + L
Sbjct: 874 NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSA 933
Query: 904 -ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNIEYVTQL 960
E ++ + E++T ++K++E ++ + E+ KK+L++ K +K +E T L
Sbjct: 934 KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL--KKKLLDQEAKLKKELEN-TAL 990
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNL-ELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +E + N + L M + N + + + + Q+ Q TE + E+N + ++ +
Sbjct: 991 ELSQKEKQFNAKMLEM--AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 1020 QKDEEIIALNQKINNAQVSYMSM-VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+K + Q+I+ Q+ V++ + K+ F + E M +E+ + ++ +
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
ELQ ++++ + L + + + ++ K E + S E V+
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Query: 1139 XXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQEQI 1196
++ + + E L+ K N L++ K ++ + L+ EL D+ ++
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLED---KSLEFKKLSEELAIQLDICCKKTE 1225
Query: 1197 NQLKSKLEQL----NTENDNLLSTVAELR---SSISSAVDQRGFEIAELWKQ--HLAQRE 1247
L++K +L +++ + +LS ++ + + + A+ + ++EL Q L + +
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
+ + QL E++ + + ++S T K ++ + Q +KE +
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLV---TEKEALQKEGGNQQQAASEKESCIT 1342
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
L+++ ++ IN + +++ E++++KV +++ +N +E +I
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL------NVQLQNSISLSEKEAAI 1396
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
++ ++ + K ++ + LE K SE +K
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQS---RF 1453
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
TQ + + ++ QL K YEK+ ++ +L+ ++ + ++ ++ E E ++ K+
Sbjct: 1454 TQHQNTVKELQIQLELKSKE----AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
K+ + L L+ + A+ E++ + + IEI +LN+ + N
Sbjct: 1510 --------------EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
++ + + + + +D ++ K L
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Score = 113 bits (271), Expect = 7e-24
Identities = 172/874 (19%), Positives = 392/874 (44%), Gaps = 76/874 (8%)
Query: 246 KDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCE 305
K +S LE + L + +++ + +LE+ L + E +
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK-EALQK 1325
Query: 306 EKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK 365
E ++ S + + +T+L K EL E++N + +EL+ K + + SK ++ + +
Sbjct: 1326 EGGNQQQAASEKESCITQLKK--ELSENINA-VTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 366 GSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKE 425
IS S ++ + + E L+Q D + ++K E + D +
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK-EKISALEQVDDWSNK 1441
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+ +K K+ I QL+L+ ++ E I++ E++++ K + L
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQI-QLELKSKEAYEKDEQINL--LKEELDQQNKRFDCL 1498
Query: 486 KQELNDEIKDVNVKD--LIEKLKSA-------EEQITQLNDEIDAANKNMIKVKSNHKLK 536
K E+ D+ + K+ L +LKS E+ ITQ EI++ N+ + ++
Sbjct: 1499 KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 537 LKQMQKTIDNFSKVSDSNKEIVRLTEE-LHHLSQKV----AELEEEKGNLQLHLVDYDSG 591
K++ + + +F ++ + V+ EE + L +V AELE +K L+ H+
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE-HVNLSVKS 1617
Query: 592 RMIESDVYKKMIEMEN---LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ E + +E E+ LAE + KA + + K L+ ++ +++Y + + + +S
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE--SHLS 1675
Query: 649 QLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+L + ++ + VH LEE++ ++ +S+ E +V + K E ++ D
Sbjct: 1676 ELNT-KLQEREREVHILEEKLKSVESSQSETLIVPRSAK-------NVAAYTEQEEADSQ 1727
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+Q +E + + L++ EK +LL ++ E++ + + F + + QER + +E+
Sbjct: 1728 GCVQKTYEEKISV---LQRNLTEK-EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E++ + +S I L+E + ++++YSL Q +K + IQ + N
Sbjct: 1784 EAKQHEDQSMIGHLQEELE-EKNKKYSL--------IVAQHVEKEGGKNNIQAKQ--NLE 1832
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
V D + ++++ L + +++++ + L+ + + ++ + ++ Y L
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL------QA 1886
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + + T+L + + K +H Q ++ E + ++EF ++ A R+K+ L
Sbjct: 1887 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLL-SNMEAQHNDLEF--KLAGAEREKQKLG 1943
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
++ + L +E++ +E L ++ E +K Q+Q+ +
Sbjct: 1944 KEI---VRLQKDLRMLRKEHQQELEILKKEYDQ------EREEKIKQEQEDLELKHNSTL 1994
Query: 1008 INEINKLNALLKQKDEEI-IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ + N L QK++E+ + + + IN AQ ++ ++ + Q K+ +++++R
Sbjct: 1995 KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR 2054
Query: 1067 VSK---QLLDSKQHNEELQILVREQDDQIKELKE 1097
+K ++LD+++ EE+ VR+ Q++EL++
Sbjct: 2055 TAKRYEEILDARE--EEMTAKVRDLQTQLEELQK 2086
Score = 46.0 bits (104), Expect = 0.001
Identities = 109/596 (18%), Positives = 243/596 (40%), Gaps = 65/596 (10%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
H +EKDN + + K+ +E + ++ ++ K + +E N +
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRI-----SSLEEANKLL 260
++ + E IA K++LL +E K+ + S L E N L
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAA------IKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 261 EAARFEISLEHSKL----AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSL 316
+ E+ + KL + + E +++ C +KT EEK S+
Sbjct: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT-YEEKISV 1740
Query: 317 EIANMTELTKKIE---------LLEH--LNCQIRQTNKELENKLA-------TMGTESKA 358
N+TE K ++ + H + CQ ++ +LE+ A +G +
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 359 VSSPSKKGSPLIS----RKSGRN---TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLE 411
+ +KK S +++ ++ G+N +++ + + ++ +I + +I +L+
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD 1860
Query: 412 -MVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH--QQHMEGPSLI-H 467
+++ V+ E + S+ + K T + + E + H+ P L+ +
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN 1920
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ D+ E+ KQ+L EI + KDL K ++++ L E D + I
Sbjct: 1921 MEAQHNDLEFKLAGAEREKQKLGKEIVRLQ-KDLRMLRKEHQQELEILKKEYDQEREEKI 1979
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH-HLSQKVAELEEEKGNLQLHLV 586
K + L+LK T+ + + N ++ + +EL + + + + +E + L
Sbjct: 1980 K-QEQEDLELKH-NSTLKQLMR--EFNTQLAQKEQELEMTIKETINKAQEVEAEL----- 2030
Query: 587 DYDSGRMIESDVYKKMIEM-ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+S + + + KK+ E ++L T + +L++++ ++ ++ LQ + +E++ K
Sbjct: 2031 -LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 2089
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + + + + L+ Q+ A K L I + KL +++ I +LE+
Sbjct: 2090 QKLEQEENPGNDNVTIMELQTQL----AQKTTL---ISDSKLKEQEFREQIHNLED 2138
>AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golgin
subfamily a, 4 variant protein.
Length = 1310
Score = 147 bits (356), Expect = 3e-34
Identities = 195/948 (20%), Positives = 409/948 (43%), Gaps = 73/948 (7%)
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM----------SA 729
LV + L+KEQL ++ +E K + L + +K+ S
Sbjct: 158 LVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSL 217
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+I+EL ++ ++Q+K Q DA ++E+D YI +++++S K R+ ++ V++
Sbjct: 218 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 277
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
LE +A+ +E ++ E +++ V L L + E L + +
Sbjct: 278 PLP-QLEPQAEVFTK--EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 334
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+++ +L E + LQ L + Q +EK DL +E TK TQLRD ++ +++
Sbjct: 335 SHKEQCTLLTSEKEALQEQLDERLQE----LEKIK--DLHMAEKTKLITQLRDAKNLIEQ 388
Query: 910 ITHEHQTLIVQKKKEI-EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+ + +I + K+++ E LE++ + R K++ + E + A +E +
Sbjct: 389 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 448
Query: 969 NNIENLNMNVEELNKMNLELID--KHVQKQQTQSPDYTEQYINEI-NKLNALLKQKDEEI 1025
+ E K+ E+ + K ++K + +Q ++ + ++ ++K+ EE
Sbjct: 449 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 508
Query: 1026 IALNQKINNAQVS--YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
IA QK++ +++ + +++ +F +++ E+ Q ++ K+ E L +
Sbjct: 509 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 568
Query: 1084 ---------LVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
++ E ++++++L++ T+ I + E + S E + +
Sbjct: 569 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 628
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSA----KLNTELQECYTKIIQL-----ETLNTEL 1185
+ V E+ + S+ +Q A KL Q+ T++ +L + T L
Sbjct: 629 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL 688
Query: 1186 TGHDVVNQEQINQLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
+++ Q I ++ K LE+L+ + L S +EL S + A + E++ L Q
Sbjct: 689 KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL-SEVLKARHKLEEELSVLKDQ--- 744
Query: 1245 QREADFQKTEHELRVQLSAFESKYEQLLDSV--QSSTQEETNKIVTMEQVTSLQNKLQDK 1302
K + EL ++ ++ ++Q +DS+ + + + +Q+ L+ L+++
Sbjct: 745 -----TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 799
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
++HL+ Q ++ + +I RSE E ++ + + + Q+
Sbjct: 800 DKHLKEHQAHVENL--EADIKRSEGELQQAS--AKLDVFQSYQSATHEQTKAYEEQLAQL 855
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK--- 1419
Q Q +L++ E L K ++ + +V +L QLE ++SE+ QK
Sbjct: 856 Q-QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 914
Query: 1420 -THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
T Y L N E E +Q LVE E I + ++ E+ IL K+ + + +
Sbjct: 915 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 974
Query: 1479 ESEIERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEIEIVTLN 1537
E E + K E+ K+ + K++ E L K L ++ AK ++ LEN +E+
Sbjct: 975 EYE-TKFKNQEKKMEKVKQKA---KEMQETLKKKLLDQEAK---LKKELENTALELSQKE 1027
Query: 1538 DEI-TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAV 1584
+ + M +A+S+ I VS ++ + E L +EL D +
Sbjct: 1028 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1075
Score = 133 bits (321), Expect = 6e-30
Identities = 242/1146 (21%), Positives = 500/1146 (43%), Gaps = 135/1146 (11%)
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS--QKVAELEEEK 578
++ +++++ S L + + +F SD + E L L+ Q + L +
Sbjct: 119 SSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRME 178
Query: 579 GNLQLHLVDYD----SGRMIESDVYKKMIEMENLAETRLKAIS-LLESQKFDLVQELHIL 633
+L + Y + +M++ + K + + L+ I+ L E + D + H L
Sbjct: 179 RSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKH-L 237
Query: 634 QQKYD-EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA-----SKKELALVIENLKL 687
Q+++D +E+K IS LQ+ + + + +D L + E+ EN +
Sbjct: 238 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 297
Query: 688 DKEQLY--GT-IKDLEN------DKEDIMNKLQNYIQENMD----LTDKLEKMSAEKISE 734
D E + GT +K LE +E+++ + + IQ + + LT + E + E++ E
Sbjct: 298 DGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQ-EQLDE 356
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRY 793
L ++ + + + + ++++ IE +E + + R + E++ + E+
Sbjct: 357 RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 416
Query: 794 SLERKADQLGSYLQE--KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL 851
L + Q+ + +E +QK SE E EL L+ + K E++ + K +
Sbjct: 417 QLRSRIKQMTTQGEELREQKEKSERAAFE-ELEKALSTAQKTEEARRKLKAEMDEQIKTI 475
Query: 852 QKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA-------------ESESTK-YQ 897
+K ++ EE +LQ LS ++Q +++K++ +A E E TK Q
Sbjct: 476 EKTSE---EERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ 532
Query: 898 TQLRDLESNLKRITHEHQT--LIVQKKKE------IEDLEIEFN---TQIESAIRDKKVL 946
T+ R+ + +K + Q+ L + ++KE +E+LE++ T+ E+ +RD +
Sbjct: 533 TREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQE 592
Query: 947 NEKYEKNI-EYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLEL---IDKHVQKQQT--- 998
E Y I E + LE LQE KN ++L +++E E NK N E+ ++KH + ++
Sbjct: 593 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 652
Query: 999 -QSPDYTE-------QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKL 1050
Q +TE QY E+ KL +Q+ E ++ + I A + M+ + KL
Sbjct: 653 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT--LEKL 710
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
T+LE++ E+ V K + EEL +L ++Q D++K+ E K+ + N + +
Sbjct: 711 DVKQTELESLSSELSEVLKA---RHKLEEELSVL-KDQTDKMKQELEAKMDEQKNHHQQQ 766
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT---E 1167
+ S I+ + L + ++ + ++ ++ A + E
Sbjct: 767 ---VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 823
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL---RSSI 1224
LQ+ K+ ++ + +EQ+ QL+ KL L TE L VAE+ + +
Sbjct: 824 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 883
Query: 1225 SSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN 1284
+ +D ++ +L +Q +K E+ ++ + YE L+ + QE+T
Sbjct: 884 CTELDAHKIQVQDLMQQ--------LEKQNSEMEQKVKSLTQVYESKLED-GNKEQEQTK 934
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE----DEKVAFXXXXXX 1340
+I+ ++ LQ + K+E + L +K + + I IL E E +++
Sbjct: 935 QILVEKENMILQMREGQKKE-IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 993
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEE----NAQLKKSSXXXXXXXXXXXXRVN 1396
L + K+ E + L ++++ NA++ + + R+
Sbjct: 994 AKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1053
Query: 1397 DAEAKVLE-LT--HQLELKD------SEIYQKTHE----YTITLTQRNDEFENVRQQLV- 1442
+ + +E LT H+ EL D ++ Q+ E + I L ++ E ++Q+++
Sbjct: 1054 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1113
Query: 1443 ---EYEKRIEDLTYEKE------SELAILRLKMHENANHYETM-QKESEIER--VKLIEE 1490
E E+ +++T+ KE + L L+ ++ + + H ++ Q E++++ KL +
Sbjct: 1114 FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1173
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
LN + E+ L +Q+ EL EE+ K +E+ + L+ + E +L +
Sbjct: 1174 LNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDK 1233
Query: 1551 SSKIQK 1556
S + +K
Sbjct: 1234 SLEFKK 1239
Score = 103 bits (248), Expect = 4e-21
Identities = 232/1170 (19%), Positives = 479/1170 (40%), Gaps = 155/1170 (13%)
Query: 150 TIKEKDNALSVLQVKMKIMETTI------LDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+++EKD +SVLQ ++ +++ + +D+ + + + + E K
Sbjct: 244 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 303
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T QQ K QEN + E + K++ K+ L+E + LE
Sbjct: 304 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 363
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ E +KL +L AK IE + E ++KG +
Sbjct: 364 IKDLHMAEKTKLITQLRD---------------AKNLIE-----QLE-QDKGMVIAETKR 402
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + +E+ E Q+R K++ T G E + S++ + + +TA K
Sbjct: 403 QMHETLEMKEEEIAQLRSRIKQM----TTQGEELREQKEKSERAA-FEELEKALSTAQKT 457
Query: 383 KSPWSQLSSETLNQ-DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+ +L +E Q T +K ++ E L+ + + +++VD SE+
Sbjct: 458 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ--------- 508
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
IA+LQ H++ + E+ K + ++E +++K K
Sbjct: 509 -------IAKLQKLHEKEL-----------ARKEQELTKKLQTREREFQEQMKVALEKSQ 550
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLT 561
E LK ++E+ Q + ++ + + + KL+ +Q+ + + R+
Sbjct: 551 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR---------TRIL 601
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
E L + + E + + +L +HL E++ K E+ + E + L+
Sbjct: 602 ELESSLEKSLQENKNQSKDLAVHL---------EAEKNKHNKEITVMVEKHKTELESLKH 652
Query: 622 QKFDL-VQELHILQQKYDEVEDKLADISQLQSDQVCSE---IKSVHLEEQIDALSASKKE 677
Q+ L ++L +L+Q+Y +KL + + + + + + I H+EE +
Sbjct: 653 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 712
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+E+L + ++ LE + + ++ QE L K+++ ++ +
Sbjct: 713 KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE---LEAKMDEQKNHHQQQVDS 769
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
I E S +T+ + +I + +L ++ + L ++++ + LE I E
Sbjct: 770 IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 829
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
K D SY + Y Q +L +L L ++ KQ+ E+E + K+
Sbjct: 830 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD------- 882
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD---LESNLKRITHEH 914
+ E +I + D+ Q + + +S + Y+++L D + K+I E
Sbjct: 883 VCTELDAHKIQVQDLMQQLEK--QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 940
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDK-KVLNEKY-------EKNIEYVTQLEAQLQE 966
+ +I+Q +E + EIE TQ SA D +LNE+Y EK +E V Q ++QE
Sbjct: 941 ENMILQ-MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 999
Query: 967 --YKNNIENLNMNVEELNKMNLELIDKHVQ---KQQTQSPDYTEQYINEINKLNALLKQK 1021
K ++ +EL LEL K Q K + + + +++L K++
Sbjct: 1000 TLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQ 1059
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE-EMQRVSKQLLDSKQHNEE 1080
E + ++++ N ++S +E KL Q +L+ + E ++Q +++ + KQ +
Sbjct: 1060 IESLTEVHRRELN------DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQ---K 1110
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+ + E+++ KE+ T L K EG+ +T+ + +
Sbjct: 1111 ILLFGCEKEEMNKEI--TWL-------KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1161
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
LK +++ V +S K NT LQE ++++L+ L E ++ ++++L
Sbjct: 1162 KLKAH-----LEKLEVDLNKSLKENTFLQE---QLVELKMLAEE-------DKRKVSELT 1206
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
SKL+ + E +L S+ + +++ + E +L ++ Q + +KTE L +
Sbjct: 1207 SKLKTTDEEFQSLKSS----HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1262
Query: 1261 ----LSAFESKYEQLLDSVQSSTQEETNKI 1286
++ SK +L + S Q T K+
Sbjct: 1263 TNELINISSSKTNAILSRI-SHCQHRTTKV 1291
Score = 101 bits (243), Expect = 2e-20
Identities = 189/982 (19%), Positives = 417/982 (42%), Gaps = 57/982 (5%)
Query: 92 ESLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTH-LSNT 150
E+L L ++ +EKIK K T +R + + + T
Sbjct: 348 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 407
Query: 151 IKEKDNALSVLQVKMKIMETTILDLQEKINEKDQI-IEAKNKATTXXXXXXXXXXXXXXX 209
++ K+ ++ L+ ++K M T +L+E+ + ++ E KA +
Sbjct: 408 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE 467
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIE-SKDVRISSLEEANKLLEAARFEIS 268
E K +E I+++ E KQ ++ ++ S + +I+ L++ ++ E AR E
Sbjct: 468 MDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK-ELARKEQE 526
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
L +E E K S E +E +EE + A +TE K+
Sbjct: 527 LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 586
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
L+ R ELE+ L E+K S K + ++ ++
Sbjct: 587 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 646
Query: 389 LSSETLNQD---TDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
L S QD T+K + + EM + K +KE ++ +K+ K
Sbjct: 647 LESLKHQQDALWTEKLQVLKQQYQTEME-KLREKCEQEKETLLKDKEIIFQAHIEEMNEK 705
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
+ +L ++ Q +E S +++E+ K + +L++EL+ +KD +K+
Sbjct: 706 T--LEKLDVK-QTELESLS--------SELSEVLKARHKLEEELSV------LKDQTDKM 748
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNFSKVSDSNKEIVR-LTEE 563
K +E +++++ + + + + H++ +++ +K + D +++ KE + L E
Sbjct: 749 K--QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 806
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQK 623
H+ A+++ +G LQ D + +S +++ E + ++ L+ +
Sbjct: 807 QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE-------EQLAQLQQKL 859
Query: 624 FDLVQELHILQQKYDEVEDKLADI-SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
DL E +L ++ EVE + D+ ++L + ++ + LE+Q + K L V
Sbjct: 860 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 919
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E+ D + K + +KE+++ +++ ++ +++ +K+SA++ S + +N E
Sbjct: 920 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILT--QKLSAKEDS--IHILNEE 975
Query: 743 EQSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICR-LEESIAVMEDRRYSLERKAD 800
++K + Q K++++ + E ++ +L ++++ + LE + + + K
Sbjct: 976 YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKML 1035
Query: 801 QLGSYLQEK-QKAYSEYTIQEDELVNRLAVL--MDHDRVVEKQLLEIEHENKELQKKNQI 857
++ A S + E + L + + + V+ ++ + +ELQ+ ++I
Sbjct: 1036 EMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEI 1095
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESNLKRITHEHQT 916
L+E + L + E+ N+ + E K T L +L+ LK+ + +
Sbjct: 1096 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1155
Query: 917 LIVQKKK---EIEDLEIEFNTQI-ESAIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNN 970
L + K +E LE++ N + E+ ++++ K E++ V++L ++L+
Sbjct: 1156 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE 1215
Query: 971 IENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ 1030
++L + E+ NK L DK ++ ++ S + Q K ALL+ K E+I ++
Sbjct: 1216 FQSLKSSHEKSNK---SLEDKSLEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISS 1271
Query: 1031 KINNAQVSYMSMVSDYESKLAQ 1052
NA +S +S +K+ +
Sbjct: 1272 SKTNAILSRISHCQHRTTKVKE 1293
>U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein.
Length = 2083
Score = 144 bits (348), Expect = 3e-33
Identities = 186/908 (20%), Positives = 395/908 (43%), Gaps = 63/908 (6%)
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
LQ ++ + + + S KI+EL ++ ++Q+K Q DA ++E+D +I +++
Sbjct: 22 LQREKKKLQGILSQSQDKSLRKIAELREELQMDQQAKKHLQEEFDASLEEKDQHISVLQT 81
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
++S K R+ ++ V++ LE +A+ +E ++ E +++ V L
Sbjct: 82 QVSLLKQRLRNGPMNVDVLKPLP-QLEPQAEVFTK--EENPESDGEPVVEDGASVKTLET 138
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
L + E L + + +++ +L E + LQ L + Q +EK DL
Sbjct: 139 LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQE----LEKIK--DLH 192
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI-EDLEIEFNTQIESAIRDKKVLNE 948
+E TK TQLRD ++ ++++ + +I + K+++ E LE++ + R K++ +
Sbjct: 193 MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ 252
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELID--KHVQKQQTQSPDYTEQ 1006
E + A +E + + E K+ E+ + K ++K + +Q
Sbjct: 253 GEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 312
Query: 1007 YINEI-NKLNALLKQKDEEIIALNQKINNAQVS--YMSMVSDYESKLAQFTTKLENMEEE 1063
++ + ++ ++K+ EE IA QK++ +++ + +++ +F +++ E+
Sbjct: 313 ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEK 372
Query: 1064 MQRVSKQLLDSKQHNEELQI---------LVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
Q ++ K+ E L + ++ E ++++++L++ T+ I + E +
Sbjct: 373 SQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE 432
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL----QE 1170
S E + + + V E+ + S+ +Q A EL Q+
Sbjct: 433 KSLQENENQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWAEELQVLKQQ 492
Query: 1171 CYTKIIQL-----ETLNTELTGHDVVNQEQINQLKSK-LEQLNTENDNLLSTVAELRSSI 1224
T++ +L + T L +++ Q I ++ K LE+L+ L S +EL S +
Sbjct: 493 YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVNQTELESLSSEL-SEV 551
Query: 1225 SSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV--QSSTQEE 1282
A + E++ L Q K + EL ++ ++ ++Q +DS+ + +
Sbjct: 552 LKARHKLEEELSVLKDQ--------TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ 603
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
+ +Q+ L+ L+++++HL+ Q ++ + +I RSE E ++ +
Sbjct: 604 RTEKALKDQINQLELLLKERDKHLKEHQAHVENL--EADIKRSEGELQQAS--AKLDVFQ 659
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
+ + Q+Q Q +L++ E L K ++ + +V
Sbjct: 660 SYQSATHEQTKAYEEQLAQLQ-QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV 718
Query: 1403 LELTHQLELKDSEIYQK----THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+L QLE ++SE+ QK T Y L N E E +Q LVE E I + ++ E
Sbjct: 719 QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 778
Query: 1459 LAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVA 1517
+ IL K+ + + +E E + K E+ K+ + K++ E L K L ++ A
Sbjct: 779 IEILTQKLSAKEDSIHILNEEYE-TKFKNQEKKMEKVKQKA---KEMQETLKKKLLDQEA 834
Query: 1518 KTNEMQTALENQEIEIVTLNDEI-TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTM 1576
K ++ LEN +E+ + + M +A+S+ I VS ++ + E L
Sbjct: 835 K---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH 891
Query: 1577 NKELLDAV 1584
+EL D +
Sbjct: 892 RRELNDVI 899
Score = 137 bits (332), Expect = 3e-31
Identities = 266/1403 (18%), Positives = 596/1403 (42%), Gaps = 119/1403 (8%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
+++ T +++ I +A ++ ++ L+ ++ + SL + AR ++ E S L
Sbjct: 506 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVNQTELESLSSELSEVLKARHKLEEELSVL 565
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIE--EKGSLEIANMTELTKKIELL 331
+ ++ +Q ++ +E + I+ EK + N EL LL
Sbjct: 566 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL-----LL 620
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM-KSPWSQLS 390
+ + +++ +EN A + + S K S +S + +K + +QL
Sbjct: 621 KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 680
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
+ L+ +T++ + ++A++E + + +L + I +D + + +
Sbjct: 681 QKLLDLETERILLTKQVAEVEAQKKDVCTEL--DAHKIQVQDLMQQLEKQNSEMEQKVKS 738
Query: 451 QLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEE 510
Q+ + +G E +I +E + ++ + K ++ L +KL + E+
Sbjct: 739 LTQVYESKLEDG------NKEQEQTKQILVEKENMILQMREGQKK-EIEILTQKLSAKED 791
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
I LN+E + KN K K K K+MQ+T+ K+ D +L +EL + + +
Sbjct: 792 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK--KLLDQE---AKLKKELENTALE 846
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
+++ E++ L + +S + SD ++ E + +++ SL E + +L +
Sbjct: 847 LSQKEKQFNAKMLEMAQANSAGI--SDAVSRL---ETNQKEQIE--SLTEVHRRELNDVI 899
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
I ++K ++ ++L +I ++Q + E+ L+++I K+E+ I LK +
Sbjct: 900 SIWEKKLNQQAEELQEIHEIQLQEKEQEV--AELKQKILLFGCEKEEMNKEITWLKEEGV 957
Query: 691 QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ 750
+ T+ +L+ + + + Q+ L LEK+ + L +EQ
Sbjct: 958 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1017
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ--- 807
+ K + +L +++ +++S E+S +ED+ ++ +++L L
Sbjct: 1018 LAEEDKRKVSEL-TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1076
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
+K +A E + +EL+N + + ++ +H ++ K +L++
Sbjct: 1077 KKTEALLE--AKTNELIN---ISSSKTNAILSRISHCQHRTTKV--KEALLIKT-----C 1124
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
++S+++ L E+ N +++ ++T QL + E+ +K + + ++L+ +K E
Sbjct: 1125 TVSELEAQLRQLTEEQNTLNISFQQATH---QLEEKENQIKSMKADIESLVTEK----EA 1177
Query: 928 LEIEFNTQIESAIRDKKV---LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM 984
L+ E Q ++A + L ++ +NI VT ++ +L+E K I +L+ + +LN
Sbjct: 1178 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1237
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
I + +++ +QY E +L ++ ++ L+++ ++S + V
Sbjct: 1238 LQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKE----KISALEQVD 1291
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL-VREQDDQIKELKETKLTFE 1103
D+ +K +++ K ++ + Q K+L Q EL+ E+D+QI LKE
Sbjct: 1292 DWSNKFSEWKKKAQSRFTQHQNTVKEL----QIQLELKSKEAYEKDEQINLLKEELDQQN 1347
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK 1163
+G + + M +N++ ++ E E+ I ++++ E
Sbjct: 1348 KRFDCLKGEMEDDKSK-MEKKESNLETELKSQTA-----RIMELEDHITQKTIEIES--- 1398
Query: 1164 LNTELQEC-YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
LN L+ K I+ + L +L + +E+ N++K E++ T + + S AEL +
Sbjct: 1399 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1458
Query: 1223 S------ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
++ +V + E+ L + ++ A + + + +++A + +QLL ++
Sbjct: 1459 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK---KQLLSQME 1515
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV-INQIEILRSEIEDEKV-AF 1334
+EE K T ++ L KLQ++E + L+EK V +Q E L + V A+
Sbjct: 1516 E--KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1573
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL-NINEENAQLKKSSXXXXXXXXXXXX 1393
+ + +++ +L + +E + S
Sbjct: 1574 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI 1633
Query: 1394 RVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE----------------FENV 1437
++ AEAK E + E+ +K +Y++ + Q ++ F++V
Sbjct: 1634 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDV 1693
Query: 1438 RQQLVE-------YEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
++ L E E++I++L + + R++M E + YE +Q +++ E
Sbjct: 1694 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1753
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L + TE S + V K L A+ N+++ L E E L EI LQ +R
Sbjct: 1754 LLEENTEEKSKSHLVQP--KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1811
Query: 1551 SSKIQKHVS-FASDTKQGRDEQL 1572
+ Q+ + + Q R+E++
Sbjct: 1812 RKEHQQELEILKKEYDQEREEKI 1834
Score = 133 bits (321), Expect = 6e-30
Identities = 306/1526 (20%), Positives = 619/1526 (40%), Gaps = 184/1526 (12%)
Query: 150 TIKEKDNALSVLQVKMKIMETTI------LDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+++EKD +SVLQ ++ +++ + +D+ + + + + E K
Sbjct: 68 SLEEKDQHISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 127
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T QQ K QEN + E + K++ K+ L+E + LE
Sbjct: 128 EDGASVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ E +KL +L AK IE + E ++KG +
Sbjct: 188 IKDLHMAEKTKLITQLRD---------------AKNLIE-----QLE-QDKGMVIAETKR 226
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + +E+ E Q+R K++ T G E + S++ + + +TA K
Sbjct: 227 QMHETLEMKEEEIAQLRSRIKQM----TTQGEELREQKEKSERAA-FEELEKALSTAQKT 281
Query: 383 KSPWSQLSSETLNQ-DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+ +L +E Q T +K ++ E L+ + + +++VD SE+
Sbjct: 282 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ--------- 332
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
IA+LQ H++ + E+ K + ++E +++K K
Sbjct: 333 -------IAKLQKLHEKEL-----------ARKEQELTKKLQTREREFQEQMKVALEKSQ 374
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLT 561
E LK ++E+ Q + ++ + + + KL+ +Q+ + + R+
Sbjct: 375 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR---------TRIL 425
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
E L + + E E + +L +HL E++ K E+ + E + L+
Sbjct: 426 ELESSLEKSLQENENQSKDLAVHL---------EAEKNKHNKEITVMVEKHKTELESLKH 476
Query: 622 QKFDL-VQELHILQQKYDEVEDKLADISQLQSDQVCSE---IKSVHLEEQIDALSASKKE 677
Q+ L +EL +L+Q+Y +KL + + + + + + I H+EE +
Sbjct: 477 QQDALWAEELQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 536
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+E+L + ++ LE + + ++ QE L K+++ ++ +
Sbjct: 537 NQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE---LEAKMDEQKNHHQQQVDS 593
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
I E S +T+ + +I + +L ++ + L ++++ + LE I E
Sbjct: 594 IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 653
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
K D SY + Y Q +L +L L ++ KQ+ E+E + K+
Sbjct: 654 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD------- 706
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD---LESNLKRITHEH 914
+ E +I + D+ Q + + +S + Y+++L D + K+I E
Sbjct: 707 VCTELDAHKIQVQDLMQQLEK--QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 764
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDK-KVLNEKY-------EKNIEYVTQLEAQLQE 966
+ +I+Q +E + EIE TQ SA D +LNE+Y EK +E V Q ++QE
Sbjct: 765 ENMILQ-MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 823
Query: 967 --YKNNIENLNMNVEELNKMNLELIDKHVQ---KQQTQSPDYTEQYINEINKLNALLKQK 1021
K ++ +EL LEL K Q K + + + +++L K++
Sbjct: 824 TLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQ 883
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQ--FTTKLENMEEEMQRVSKQLL----DSK 1075
E + ++++ N +S + +++ Q +L+ E+E+ + +++L + +
Sbjct: 884 IESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKE 943
Query: 1076 QHNEELQILVRE---QDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ N+E+ L E QD + EL+E + + +N + + + +E + D N
Sbjct: 944 EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1003
Query: 1131 XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV 1190
LK+ EE+ +R V E ++KL T +E + E N L +
Sbjct: 1004 ENTFLQEQLVELKMLAEED---KRKV-SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL 1059
Query: 1191 VNQEQINQLKSKLEQLNTENDNLL-STVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
++ +L +L+ + + LL + EL + SS + I+ + +EA
Sbjct: 1060 EFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEAL 1119
Query: 1250 FQK--TEHELRVQLSAFESKYEQLLDSVQSST---QEETNKIVTME-QVTSL-------- 1295
K T EL QL + L S Q +T +E+ N+I +M+ + SL
Sbjct: 1120 LIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQ 1179
Query: 1296 ------QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX----------- 1338
Q +KE + L+++ ++ IN + +++ E++++KV
Sbjct: 1180 KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1239
Query: 1339 -XXXXXXXXXXXXDLRTENQSYK-----QMQEQS--ILNINEEN----AQLKKSSXXXXX 1386
LR + K Q+Q+ S + +++E Q+ S
Sbjct: 1240 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1299
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI---TLTQRNDEFENVRQQLVE 1443
R + V EL QLELK E Y+K + + L Q+N F+ ++ ++ +
Sbjct: 1300 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1359
Query: 1444 YEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNK 1503
+ ++E E+EL ++ E +H QK EIE + + + N + + +
Sbjct: 1360 DKSKMEKKESNLETELKSQTARIMELEDH--ITQKTIEIESLNEVLK-NYNQQKDIEHKE 1416
Query: 1504 QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
V +L E K N ++ A E +I+TL +++ +++ + +++ HV+ +
Sbjct: 1417 LVQKLQHFQELGEEKDNRVKEA----EEKILTLENQVYSMKAELETKKKELE-HVNLSVK 1471
Query: 1564 TKQGRDEQLDNTMNKELLDAVPRAEL 1589
+K+ + L++ + E A AEL
Sbjct: 1472 SKEEELKALEDRLESE--SAAKLAEL 1495
Score = 130 bits (314), Expect = 4e-29
Identities = 211/1055 (20%), Positives = 447/1055 (42%), Gaps = 82/1055 (7%)
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR 612
S ++I L EEL Q L+EE + S + + K+ + +
Sbjct: 40 SLRKIAELREELQMDQQAKKHLQEEFDASLEEKDQHISVLQTQVSLLKQRLRNGPMNVDV 99
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
LK + LE Q +E + VED A + L++ Q + + L+ + +
Sbjct: 100 LKPLPQLEPQAEVFTKEENPESDGEPVVEDG-ASVKTLETLQQRVKRQENLLKRCKETIQ 158
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTDKLEKMSA 729
+ K++ L+ + +EQL +++LE K+ M KL +++ +L ++LE+
Sbjct: 159 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 218
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK-YKSRICRLEESIAVM 788
I+E +++ + K + + ++I++ E + + K ++ LE++++
Sbjct: 219 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 278
Query: 789 EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEKQLLEIE- 845
+ + + ++ ++ +K E I + ++R+ V+ + E+Q+ +++
Sbjct: 279 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 338
Query: 846 -HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
HE KEL +K Q E + LQ + Q+ +EK+ L S+ + Q L
Sbjct: 339 LHE-KELARKEQ---ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA--- 391
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
L+ + + + ++ + + ++ DL+ E T + + L + ++N L L
Sbjct: 392 --LEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENENQSKDLAVHL 449
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQ--QTQSPDYTEQYINEINKLNALLKQKD 1022
+ KN + E +K LE + KH Q + +QY E+ KL +Q+
Sbjct: 450 EAEKNKHNKEITVMVEKHKTELESL-KHQQDALWAEELQVLKQQYQTEMEKLREKCEQEK 508
Query: 1023 EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
E ++ + I A + M+ KL T+LE++ E+ V K + EEL
Sbjct: 509 ETLLKDKEIIFQAHIEEMN--EKTLEKLDVNQTELESLSSELSEVLKA---RHKLEEELS 563
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
+L ++Q D++K+ E K+ + N + + + S I+ + L
Sbjct: 564 VL-KDQTDKMKQELEAKMDEQKNHHQQQ---VDSIIKEHEVSIQRTEKALKDQINQLELL 619
Query: 1143 KVQEEEEFIQERSV----LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
++E ++ ++E L+ + ELQ+ K+ ++ + +EQ+ Q
Sbjct: 620 -LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 678
Query: 1199 LKSKLEQLNTENDNLLSTVAEL---RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
L+ KL L TE L VAE+ + + + +D ++ +L +Q +K
Sbjct: 679 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--------LEKQNS 730
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
E+ ++ + YE L+ + QE+T +I+ ++ LQ + K+E + L +K +
Sbjct: 731 EMEQKVKSLTQVYESKLED-GNKEQEQTKQILVEKENMILQMREGQKKE-IEILTQKLSA 788
Query: 1316 VINQIEILRSEIE----DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN 1371
+ I IL E E +++ L + K+ E + L ++
Sbjct: 789 KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELS 848
Query: 1372 EE----NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE-LT--HQLELKD------SEIYQ 1418
++ NA++ + + R+ + + +E LT H+ EL D ++ Q
Sbjct: 849 QKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQ 908
Query: 1419 KTHE----YTITLTQRNDEFENVRQQLV----EYEKRIEDLTYEKE------SELAILRL 1464
+ E + I L ++ E ++Q+++ E E+ +++T+ KE + L L+
Sbjct: 909 QAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 968
Query: 1465 KMHENANHYETM-QKESEIER--VKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNE 1521
++ + + H ++ Q E++++ KL +LN + E+ L +Q+ EL EE+ K +E
Sbjct: 969 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1028
Query: 1522 MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+ + L+ + E +L + S + +K
Sbjct: 1029 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1063
Score = 113 bits (271), Expect = 7e-24
Identities = 172/874 (19%), Positives = 392/874 (44%), Gaps = 76/874 (8%)
Query: 246 KDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCE 305
K +S LE + L + +++ + +LE+ L + E +
Sbjct: 1122 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK-EALQK 1180
Query: 306 EKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK 365
E ++ S + + +T+L K EL E++N + +EL+ K + + SK ++ + +
Sbjct: 1181 EGGNQQQAASEKESCITQLKK--ELSENINA-VTLMKEELKEKKVEISSLSKQLTDLNVQ 1237
Query: 366 GSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKE 425
IS S ++ + + E L+Q D + ++K E + D +
Sbjct: 1238 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK-EKISALEQVDDWSNK 1296
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+ +K K+ I QL+L+ ++ E I++ E++++ K + L
Sbjct: 1297 FSEWKKKAQSRFTQHQNTVKELQI-QLELKSKEAYEKDEQINL--LKEELDQQNKRFDCL 1353
Query: 486 KQELNDEIKDVNVKD--LIEKLKSA-------EEQITQLNDEIDAANKNMIKVKSNHKLK 536
K E+ D+ + K+ L +LKS E+ ITQ EI++ N+ + ++
Sbjct: 1354 KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1413
Query: 537 LKQMQKTIDNFSKVSDSNKEIVRLTEE-LHHLSQKV----AELEEEKGNLQLHLVDYDSG 591
K++ + + +F ++ + V+ EE + L +V AELE +K L+ H+
Sbjct: 1414 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE-HVNLSVKS 1472
Query: 592 RMIESDVYKKMIEMEN---LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ E + +E E+ LAE + KA + + K L+ ++ +++Y + + + +S
Sbjct: 1473 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE--SHLS 1530
Query: 649 QLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+L + ++ + VH LEE++ ++ +S+ E +V + K E ++ D
Sbjct: 1531 ELNT-KLQEREREVHILEEKLKSVESSQSETLIVPRSAK-------NVAAYTEQEEADSQ 1582
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+Q +E + + L++ EK +LL ++ E++ + + F + + QER + +E+
Sbjct: 1583 GCVQKTYEEKISV---LQRNLTEK-EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1638
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E++ + +S I L+E + ++++YSL Q +K + IQ + N
Sbjct: 1639 EAKQHEDQSMIGHLQEELE-EKNKKYSL--------IVAQHVEKEGGKNNIQAKQ--NLE 1687
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
V D + ++++ L + +++++ + L+ + + ++ + ++ Y L
Sbjct: 1688 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL------QA 1741
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + + T+L + + K +H Q ++ E + ++EF ++ A R+K+ L
Sbjct: 1742 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLL-SNMEAQHNDLEF--KLAGAEREKQKLG 1798
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
++ + L +E++ +E L ++ E +K Q+Q+ +
Sbjct: 1799 KEI---VRLQKDLRMLRKEHQQELEILKKEYDQ------EREEKIKQEQEDLELKHNSTL 1849
Query: 1008 INEINKLNALLKQKDEEI-IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ + N L QK++E+ + + + IN AQ ++ ++ + Q K+ +++++R
Sbjct: 1850 KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR 1909
Query: 1067 VSK---QLLDSKQHNEELQILVREQDDQIKELKE 1097
+K ++LD+++ EE+ VR+ Q++EL++
Sbjct: 1910 TAKRYEEILDARE--EEMTAKVRDLQTQLEELQK 1941
Score = 73.3 bits (172), Expect = 6e-12
Identities = 145/682 (21%), Positives = 292/682 (42%), Gaps = 100/682 (14%)
Query: 931 EFNTQIESAIRDKK----VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
E T + R+KK +L++ +K++ + +L +LQ + ++L EE + +L
Sbjct: 14 ELVTAYQMLQREKKKLQGILSQSQDKSLRKIAELREELQMDQQAKKHLQ---EEFDA-SL 69
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
E D+H+ QTQ +LLKQ+ N +N V + +
Sbjct: 70 EEKDQHISVLQTQV---------------SLLKQR-----LRNGPMN---VDVLKPLPQL 106
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI 1106
E + A+ TK EN E + + V + K E LQ V+ Q++ +K KET +
Sbjct: 107 EPQ-AEVFTKEENPESDGEPVVEDGASVKT-LETLQQRVKRQENLLKRCKET-----IQS 159
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT 1166
K + +++S E + + + ++QE E+ + + + KL T
Sbjct: 160 HKEQCTLLTSEKEALQEQLDE---------------RLQELEKI---KDLHMAEKTKLIT 201
Query: 1167 ELQECYTKIIQLE------TLNTELTGHDV--VNQEQINQLKSKLEQLNTENDNL----- 1213
+L++ I QLE T+ H+ + +E+I QL+S+++Q+ T+ + L
Sbjct: 202 QLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE 261
Query: 1214 ---LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
+ EL ++S+A Q+ E K + ++ +KT E R+ L S+ +Q
Sbjct: 262 KSERAAFEELEKALSTA--QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQ 319
Query: 1271 -LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL-RNLQEKYADVINQIEILRSEIE 1328
++D ++ S++E+ K+ + + +L KE+ L + LQ + + Q+++ +E
Sbjct: 320 EVVDVMKKSSEEQIAKLQKLH-----EKELARKEQELTKKLQTREREFQEQMKV---ALE 371
Query: 1329 DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
+ + +L + ++ E + ++ +E A+ ++
Sbjct: 372 KSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQE-AETYRTRILELESS 430
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVR-QQLVEYEKR 1447
+ N+ ++K +L LE +E + E T+ + + E E+++ QQ + +
Sbjct: 431 LEKSLQENENQSK--DLAVHLE---AEKNKHNKEITVMVEKHKTELESLKHQQDALWAEE 485
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
++ L + ++E+ LR K + ET+ K+ EI IEE+N K E + +N+
Sbjct: 486 LQVLKQQYQTEMEKLREKCEQEK---ETLLKDKEIIFQAHIEEMNEKTLEKLDVNQ---- 538
Query: 1508 LNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQG 1567
LE ++ +E+ A E E+ L D+ ++ + A + + H D+
Sbjct: 539 --TELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK 596
Query: 1568 RDEQLDNTMNKELLDAVPRAEL 1589
E K L D + + EL
Sbjct: 597 EHEVSIQRTEKALKDQINQLEL 618
Score = 46.0 bits (104), Expect = 0.001
Identities = 109/596 (18%), Positives = 243/596 (40%), Gaps = 65/596 (10%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
H +EKDN + + K+ +E + ++ ++ K + +E N +
Sbjct: 1423 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1482
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRI-----SSLEEANKLL 260
++ + E IA K++LL +E K+ + S L E N L
Sbjct: 1483 RLESESAAKLAELKRKAEQKIAA------IKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1536
Query: 261 EAARFEISLEHSKL----AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSL 316
+ E+ + KL + + E +++ C +KT EEK S+
Sbjct: 1537 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT-YEEKISV 1595
Query: 317 EIANMTELTKKIE---------LLEH--LNCQIRQTNKELENKLA-------TMGTESKA 358
N+TE K ++ + H + CQ ++ +LE+ A +G +
Sbjct: 1596 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1655
Query: 359 VSSPSKKGSPLIS----RKSGRN---TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLE 411
+ +KK S +++ ++ G+N +++ + + ++ +I + +I +L+
Sbjct: 1656 LEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD 1715
Query: 412 -MVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH--QQHMEGPSLI-H 467
+++ V+ E + S+ + K T + + E + H+ P L+ +
Sbjct: 1716 SCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN 1775
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ D+ E+ KQ+L EI + KDL K ++++ L E D + I
Sbjct: 1776 MEAQHNDLEFKLAGAEREKQKLGKEIVRLQ-KDLRMLRKEHQQELEILKKEYDQEREEKI 1834
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH-HLSQKVAELEEEKGNLQLHLV 586
K + L+LK T+ + + N ++ + +EL + + + + +E + L
Sbjct: 1835 K-QEQEDLELKH-NSTLKQLMR--EFNTQLAQKEQELEMTIKETINKAQEVEAEL----- 1885
Query: 587 DYDSGRMIESDVYKKMIEM-ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+S + + + KK+ E ++L T + +L++++ ++ ++ LQ + +E++ K
Sbjct: 1886 -LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 1944
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + + + + L+ Q+ A K L I + KL +++ I +LE+
Sbjct: 1945 QKLEQEENPGNDNVTIMELQTQL----AQKTTL---ISDSKLKEQEFREQIHNLED 1993
>AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein.
Length = 1870
Score = 135 bits (326), Expect = 1e-30
Identities = 225/1095 (20%), Positives = 447/1095 (40%), Gaps = 74/1095 (6%)
Query: 475 VNEIAKVQEQLKQELND-EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
V+++ + K+ L+D E V++L E + E T L D+++ K+
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
K L+ K D + K+I L EE L + +E +L L
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 594 IESDVYKKM-IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
+ K + E+ L +RL LE + L + + L+ D VE + I +++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLK---LEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
+ K LE +I S + + ++L +K QL TI+ L + E + L+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE- 557
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKI--QTQFGIDAKIQERDLYIENIES 769
QEN L + + A++ E+++KI ++ +K+ + + I+
Sbjct: 558 --QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 770 ELSKYKS---RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL YK R LE + +E L++K L EK +A + + + +
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQENSELERENRK 674
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
L +D + + QL +E EN +L ++N L ++L+ + M Q ++ N+
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-----LQLENKE 729
Query: 887 DLAESESTKYQTQLRDLE-SNLKRITHEHQTLIVQKKKEIEDLEIEFNT--QIESAIRDK 943
+E E K +L +R+ +Q L ++ ++ + LE Q+ES ++D
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ-KQQTQSPD 1002
++ N+ +KN+E + +L++ + ++L +L K +L ++ + +QQ + D
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 1003 YTEQY----INEINKLNALLKQK----DEEIIALNQK-------INNAQVSYMSMVSDYE 1047
T + I + K N L ++ E + L + + A + ++V+ E
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK---ETKLTFEM 1104
+++ K + M ++++++ +L + E L + DD+ K L+ E+ L +
Sbjct: 910 DLVSE-KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV-QEEEEFIQERSVLQEQSAK 1163
I + + + + +E ++ + LK Q+EE +Q + + K
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
E QE ++++++ E+ ++ Q + LK++L+QL T+N+NL + + L+
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET 1283
S +Q L + A Q L Q ++ ++ QLL S E
Sbjct: 1089 TVSLQEQ---------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1139
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXX 1343
+ I E + SL + L E L L E+ A ++ E L S+ K A
Sbjct: 1140 SVIKEREDLKSLYDSLIKDHEKLELLHERQA---SEYESLISKHGTLKSAHKNLEVEHRD 1196
Query: 1344 XXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
L+ + Q + +++ +L + +E L+ + ND L
Sbjct: 1197 LEDRYNQLLKQKGQ-LEDLEK--MLKVEQEKMLLENKNHETVAAEYKKLCGENDR----L 1249
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
T+ LK++E+ Q H+ +L N + E R + E+ K E+ +L I
Sbjct: 1250 NHTYSQLLKETEVLQTDHKNLKSLL-NNSKLEQTRLE-AEFSK-----LKEQYQQLDITS 1302
Query: 1464 LKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE----VAKT 1519
K++ ++ E E L++++ + ++ +L +Q E E + K
Sbjct: 1303 TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
Query: 1520 NEMQTALENQEIEIV 1534
NE++ E E +I+
Sbjct: 1363 NELRRQKEKLEEKIM 1377
Score = 113 bits (271), Expect = 7e-24
Identities = 233/1149 (20%), Positives = 490/1149 (42%), Gaps = 119/1149 (10%)
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
AK++ +L+QEL + K + D ++L+ E ++ +L E N N++ + ++
Sbjct: 258 AKIR-RLRQELEE--KTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRD 310
Query: 539 QMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL------HLVDYDSGR 592
++ + +V E+ R E LH + A +EE K + Q+ L D G
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 593 MIESDVYKKMIEMENL-AETRLKAISL---LESQKF-DLVQELHILQ----QKYDEVEDK 643
SD + +E ENL + +L + + ++ +K +L++E L+ Q DE
Sbjct: 371 RARSDKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 644 LADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK--EQLYGTIKDLEN 701
++ Q+ SE L +++ L++S+ L L +EN L K E+L T+ +E
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS------KIQTQFGIDA 755
+ I+ K++ +EN L+ K+E + E + E + N + S K Q + I+
Sbjct: 489 NASKIL-KME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY-SLERKADQLGSYLQEKQKAYS 814
+ + I+ +E E + L + + + R +E++ L ++E S
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
+ ++ ++ L +H + ++ E+E+E L+K+N++L ++ NL+I+
Sbjct: 605 KIEFEKRQIKKEL----EHYKEKGERAEELENELHHLEKENELLQKKITNLKIT------ 654
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
EK + SE + +L+ + K +T + ++L +KE L+ E N
Sbjct: 655 -----CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL----EKENSQLD-EENL 704
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
++ + K + K + +LE++ ++ K +E L + ++ ++ + ++
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS--YMSMVSDYESKLAQ 1052
Q+ Q E +I +L + L+ + E L + + ++S + + L Q
Sbjct: 765 NQRLQKT--LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
T++LE ++++++ +K+L +Q E + E + +I L++ T I G+
Sbjct: 823 ETSQLEKDKKQLEKENKRL---RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GI 875
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
S + + N + + ++ E+ + E+ Q+ +N +L++
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLR--EDLVSEKLKTQQ----MNNDLEK-L 928
Query: 1173 TKIIQLETLNTELTGHDVVN-QEQINQLKSKLE-----QLNTENDNLLSTVAELRSSISS 1226
T ++ LN E HD + ++ L+SKLE L + + + + A L S ++
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES-TN 987
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
Q E+ + K + A ++ ++ + +S ++K+E+ + +++
Sbjct: 988 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047
Query: 1287 VTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ +E+ +LQ + Q + L+ L+ + ++ Q +IL ++ + V+
Sbjct: 1048 IEVERNNATLQAEKQALKTQLKQLETQNNNL--QAQIL--ALQRQTVSLQEQNTTLQTQN 1103
Query: 1346 XXXXXDLRTEN-QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
+ T N QS M + + L I + + + + S + + LE
Sbjct: 1104 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1163
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDE-----FENVRQQLVEYEKRIEDLTYEKESEL 1459
L H+ + + E H T+ +N E E+ QL++ + ++EDL E L
Sbjct: 1164 LLHERQASEYESLISKHG-TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL----EKML 1218
Query: 1460 AILRLKM-HENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAK 1518
+ + KM EN NH ET+ E + KL E+ LN ++L K E
Sbjct: 1219 KVEQEKMLLENKNH-ETVAAEYK----KL-------CGENDRLNHTYSQLLKETEVLQTD 1266
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQNMVR---ASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+++ L N ++E L E + L+ + +S+K+ S K +E+
Sbjct: 1267 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE---- 1322
Query: 1576 MNKELLDAV 1584
N+ LLD +
Sbjct: 1323 -NRHLLDQI 1330
Score = 106 bits (254), Expect = 8e-22
Identities = 181/867 (20%), Positives = 386/867 (44%), Gaps = 71/867 (8%)
Query: 295 LAKQSIEPSCEE-KTEIE--EKGSLEIANMTE----LTKKIELLEHLNCQIRQT------ 341
+ QS+ + EE +T ++ E + +I M + L+KK+E+LE+ Q +Q+
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 342 -NKELENKLATMGTESKAVSSPSKKGSPLISRKSG--RNTASKMKSPWSQLSSETLNQDT 398
+K+L + A + + + S++ ++ +++ T S ++ SQ+S+E +D
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR-SQISAEARVKDI 585
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
+K+ NK ++ L+K +K + E + ++ L LE +
Sbjct: 586 EKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL---HHLEKEN 641
Query: 459 HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLN 516
+ + ++ E + + + +L++E N ++K + K+L +L+S E++ +QL+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQ---KTIDNFSKVSDSNKEIVRLT-EELHHLSQKVA 572
+E +N+ +K +K+ Q+Q K +++ + E+++ + ++ L
Sbjct: 701 EENLELRRNVESLKC-ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 573 ELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMEN-LAETRLKAISLLESQKFDLVQEL 630
L+ E LQ L + + + +ES++ + +EMEN + L+ + + + L +E
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESEL--QDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 631 HILQQKYDEVE-DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L+Q+ ++E DK + + + +EIK LEE + +KE + + + + K
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL--EKMSAEKISELLAKINHEEQSKI 747
E +K+LE + ++++ + I+ + L + L EK+ ++++ L K+ HE +
Sbjct: 878 ESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 748 QTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+ + Q D + +ES+L S K + EE IA +E R QL L
Sbjct: 937 LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
Query: 807 QEKQKAYSEYTIQEDE--LVNRLAVLMDHDRVVE-------KQLLEIEHENKELQKKNQI 857
+ +K Y ++DE +V + D E ++LL+++ E+++ N
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 858 LLEENQNLQISLSDMQQHYNAL----VEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
L E Q L+ L ++ N L + +T + ++T QTQ L+ + +
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL-NS 1115
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL----EAQLQEYKN 969
T ++ + ++ + + ES I++++ L Y+ I+ +L E Q EY++
Sbjct: 1116 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1175
Query: 970 NIE---NLNMNVEELNKMNLELIDKHVQ--KQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
I L + L + +L D++ Q KQ+ Q D + E K+ LL+ K+ E
Sbjct: 1176 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM--LLENKNHE 1233
Query: 1025 IIAL--------NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+A N ++N+ + ++ + L N + E R+ + K+
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Query: 1077 HNEELQILVREQDDQIKELKETKLTFE 1103
++L I + ++Q + L + K E
Sbjct: 1294 QYQQLDITSTKLNNQCELLSQLKGNLE 1320
Score = 105 bits (253), Expect = 1e-21
Identities = 193/909 (21%), Positives = 386/909 (42%), Gaps = 84/909 (9%)
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSK 746
++ L + D + + +L+ ++ +D +LE+M E ++ + + + +S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+ +DA ++E+ + ++ +ESE+S+YK R+ +E A +E E K D L
Sbjct: 306 RMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVE------ELKEDN--QVL 356
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
E + + ++L L + ++ +L ++E E +KK + L+EEN L+
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 867 ISLS---DMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESN-LKRITHEHQTLI--V 919
++ D H +E+ +RT +L+E+ ++ +L S+ L ++ E+Q+L V
Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 920 QKKKEIEDLEIEFN-TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN--------- 969
++ + D +E N ++I ++ + L++K E + Q + LQ +N
Sbjct: 477 EELRTTVD-SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 970 -----NIENLNMNVEELNKMNLELIDKH----VQKQQTQSPDYTEQYINEINKLNALLKQ 1020
IE L N E K+ LE ++H V + +S E + +I K N +L +
Sbjct: 536 AQLEKTIETLRENSERQIKI-LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE 594
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
+E + KI + + Y+ K + +L ++E+E + + K++ + K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E+++ L +E + +E ++ K T + + + S E D N++
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLD-SFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ---- 1193
+K+ + + E L+ + +L L+ + E L G D+ NQ
Sbjct: 714 KCASMKMAQLQ---LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 1194 ------EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
++I QL+S+L+ L EN L + EL+ S S ++Q E L +Q +Q E
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL-EQETSQLE 828
Query: 1248 ADFQKTEHE---LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN--KLQDK 1302
D ++ E E LR Q ++ E+ ++V+ E+ NK ++ E ++ +L++
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEE--NNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXX-DLRTENQSYKQ 1361
E+ + L ++ I + LR ++ EK+ L E + +
Sbjct: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
Query: 1362 MQEQSILNINEENAQ--LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
+ E + LKKS R+ ++ +L +L+ +K
Sbjct: 947 QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT-----VKK 1001
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRI--EDLTYEKESELAILRL-KMHENANHYETM 1476
+E L QR DE +++V+ I ED +E+ES+ L K+ + E
Sbjct: 1002 NYE---ALKQRQDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1053
Query: 1477 QKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
+ E+ L +L T++ +L Q+ L + + +QT ++E TL
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1113
Query: 1537 NDEITNLQN 1545
N + T+L N
Sbjct: 1114 NSQSTSLMN 1122
Score = 98.3 bits (234), Expect = 2e-19
Identities = 158/809 (19%), Positives = 336/809 (41%), Gaps = 68/809 (8%)
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+Q I+ ++ L+++ + E ++ I L E + ++ GS +
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ ++ +++ + ++ L +QLL+ + E ++++ + + L +EN NL
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 869 LSDMQQH---YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ + +AL EKA R D ESE ++Y+ +L D+E R V++ KE
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR---------VEELKED 352
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN 985
+ +E T +E + + ++K + + QL+A+L + + + +EEL + N
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 986 LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD 1045
+ L + QKQ + + +I++ + L + + +L ++N S + +
Sbjct: 413 MTL--EMAQKQSMDESLHLGWELEQISRTSELSEAPQK---SLGHEVNELTSSRLLKLEM 467
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN 1105
L + +L + ++ + ++L ++ N+ L V +++I + K++ L N
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS-LQNCQN 526
Query: 1106 IPK---TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA 1162
+ K E + TIE + +++ + QE E Q S L+++S
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSER-----------QIKILEQENEHLNQTVSSLRQRS- 574
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
+++ E ++ +E N L E I + SKL ++ E + + +
Sbjct: 575 QISAE-----ARVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
+R E+ E HL + QK L++ E+ L+ S + E
Sbjct: 623 K-----GERAEEL-ENELHHLEKENELLQKKITNLKITCEKIEA-----LEQENSELERE 671
Query: 1283 TNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR-SEIEDEKVAFXXXXXX 1340
K+ T++ +L +L+ E+ L E+ ++ +E L+ + ++ ++
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
+L + + E S ++ EN +L+K+ + D E
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 1401 KVLELTHQL-ELK-DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ L L ELK S+ ++ + +L Q + E ++QL + KR+ K++
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 1459 LAILRLKMHENANHYETMQKESEI-----ERVKLIEELNVKITESVSLN-KQVAELNKAL 1512
L +K+ +T+ KE I R+K +E+ N ++ + +++ K + L + L
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 1513 EEEVAKTNEMQTALE--NQEIEIVTLNDE 1539
E KT +M LE E+E + LN E
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 91.9 bits (218), Expect = 2e-17
Identities = 173/864 (20%), Positives = 368/864 (42%), Gaps = 79/864 (9%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIE--SKDVRISSLEEANKLLEAARFEISLE 270
+T ++ ++ Q + E E ++ L+ S + R+ +E+ NK+L + E S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
SK+ E E+ + +E + E +I N+ +KIE
Sbjct: 603 LSKI--EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR--KSGRNTAS----KMKS 384
LE N ++ + N++L+ L + + + S K+ S L + RN S MK
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 385 PWSQLSSETLNQDTD-------------KKINKNEIA--KLEMVIQSLNKDLVDKEYVIS 429
QL ++ L + + KK + E++ L++ Q L K L + I
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 430 EKDTXXXXXXXXXXGKDTLIAQLQLE----HQQHMEGPSLIHVGTNTE-DVNEIAKVQEQ 484
+ ++ + +L++ Q E SL + E D ++ K ++
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK-T 543
L+Q+ EIKD +++ K+ + E++ L+ EI ++ +++K K + +++ T
Sbjct: 841 LRQQA--EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Query: 544 IDNFSKVS---DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY----DSGRMIES 596
ID + V+ D E ++ + + L + ELE+ N + L D D +++ES
Sbjct: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
Query: 597 DVYKKMIEMENLAETRLKAIS--LLESQKFD--LVQELHILQQKYDEVEDKLADISQLQS 652
+ + + + E ++ A+ L ES ++ L QEL +++ Y+ ++ + + +QS
Sbjct: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018
Query: 653 D-QVCSEIKSVHLEEQIDALSASK-KELALVIE----NLKLDKEQLYGTIKDLENDKEDI 706
+ E E Q K K+ + +E L+ +K+ L +K LE ++
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
++ ++ + L ++ + + + QS IQ+ L EN
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL--EN 1136
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSL-ERKADQLGSYLQEK---QKAYSEYTIQEDE 822
+ K + + L +S+ ++ L ER+A + S + + + A+ ++ +
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1196
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
L +R L+ KQ ++E K L+ + + +L EN+N + ++ Y L +
Sbjct: 1197 LEDRYNQLL-------KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE----YKKLCGE 1245
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
+R + S+ K L+ NLK +L+ K E LE EF ++++ +
Sbjct: 1246 NDRLNHTYSQLLKETEVLQTDHKNLK-------SLLNNSKLEQTRLEAEF-SKLKEQYQQ 1297
Query: 943 KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPD 1002
+ + K E ++QL+ L+E ++ + ++ L N L++++++ + +
Sbjct: 1298 LDITSTKLNNQCELLSQLKGNLEEENRHLLD---QIQTLMLQNRTLLEQNMESKDLFHVE 1354
Query: 1003 YTEQYINEINKLNALLKQKDEEII 1026
QYI+++N+L ++ +E+I+
Sbjct: 1355 -QRQYIDKLNELRRQKEKLEEKIM 1377
>BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein.
Length = 1843
Score = 134 bits (325), Expect = 2e-30
Identities = 227/1096 (20%), Positives = 448/1096 (40%), Gaps = 75/1096 (6%)
Query: 475 VNEIAKVQEQLKQELND-EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
V+++ + K+ L+D E V++L E + E T L D+++ K+
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
K L+ K D + K+I L EE L + +E +L L
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 594 IESDVYKKM-IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
+ K + E+ L +RL LE + L + + L+ D VE + I +++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLK---LEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
+ K LE +I S + + ++L +K QL TI+ L + E + L+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE- 557
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKI--QTQFGIDAKIQERDLYIENIES 769
QEN L + + A++ E+++KI ++ +K+ + + I+
Sbjct: 558 --QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 770 ELSKYKS---RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL YK R LE + +E L++K L EK +A + + + +
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQENSELERENRK 674
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
L +D + + QL +E EN +L ++N L ++L+ + M Q ++ N+
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-----LQLENKE 729
Query: 887 DLAESESTKYQTQLRDLE-SNLKRITHEHQTLIVQKKKEIEDLEIEFNT--QIESAIRDK 943
+E E K +L +R+ +Q L ++ ++ + LE Q+ES ++D
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ-KQQTQSPD 1002
++ N+ +KN+E + +L++ + ++L +L K +L ++ + +QQ + D
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 1003 YTEQY----INEINKLNALLKQK----DEEIIALNQK-------INNAQVSYMSMVSDYE 1047
T + I + K N L ++ E + L + + A + ++V+ E
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKL--TFEMN 1105
+++ K + M ++++++ +L + E L + DD +L E+KL T + +
Sbjct: 910 DLVSE-KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 1106 IPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKV-QEEEEFIQERSVLQEQSA 1162
+ E I + + +E ++ + LK Q+EE +Q + +
Sbjct: 969 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
K E QE ++++++ E+ ++ Q + LK++L+QL T+N+NL + + L+
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1088
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
S +Q L + A Q L Q ++ ++ QLL S E
Sbjct: 1089 QTVSLQEQ---------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
+ I E + SL + L E L L E+ A ++ E L S+ K A
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHERQA---SEYESLISKHGTLKSAHKNLEVEHR 1196
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
L+ + Q + +++ +L + +E L+ + ND
Sbjct: 1197 DLEDRYNQLLKQKGQ-LEDLEK--MLKVEQEKMLLENKNHETVAAEYKKLCGENDR---- 1249
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
L T+ LK++E+ Q H+ +L N + E R + E+ K E+ +L I
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLL-NNSKLEQTRLE-AEFSK-----LKEQYQQLDIT 1302
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE----VAK 1518
K++ ++ E E L++++ + ++ +L +Q E E + K
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 1519 TNEMQTALENQEIEIV 1534
NE++ E E +I+
Sbjct: 1363 LNELRRQKEKLEEKIM 1378
Score = 112 bits (269), Expect = 1e-23
Identities = 226/1099 (20%), Positives = 472/1099 (42%), Gaps = 95/1099 (8%)
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
AK++ +L+QEL + K + D ++L+ E ++ +L E N N++ + ++
Sbjct: 258 AKIR-RLRQELEE--KTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRD 310
Query: 539 QMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL------HLVDYDSGR 592
++ + +V E+ R E LH + A +EE K + Q+ L D G
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 593 MIESDVYKKMIEMENL-AETRLKAISL---LESQKF-DLVQELHILQ----QKYDEVEDK 643
SD + +E ENL + +L + + ++ +K +L++E L+ Q DE
Sbjct: 371 RARSDKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 644 LADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK--EQLYGTIKDLEN 701
++ Q+ SE L +++ L++S+ L L +EN L K E+L T+ +E
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS------KIQTQFGIDA 755
+ I+ K++ +EN L+ K+E + E + E + N + S K Q + I+
Sbjct: 489 NASKIL-KME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY-SLERKADQLGSYLQEKQKAYS 814
+ + I+ +E E + L + + + R +E++ L ++E S
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ- 873
+ ++ ++ L +H + ++ E+E+E L+K+N++L ++ NL+I+ ++
Sbjct: 605 KIEFEKRQIKKEL----EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 874 -QHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTL--IVQKKK----EI 925
+ N+ +E+ NR +S K T QL LE ++ E+ L V+ K ++
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 926 EDLEIEFNTQIESAIRDKK----VLNEKYEK--NIEYVTQ-LEAQLQEYKNNIENLNMNV 978
L++E N ++ES K +L ++K +E Q L+ + Q + +EN N +
Sbjct: 721 AQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
Query: 979 EELNK--MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
++L +LE+ ++ +QK + + + + ++ K N L+Q+ ++ +++
Sbjct: 780 QQLESELQDLEMENQTLQK-NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
++ L + K+ N+E+E + +SK++ K+ L+ L +E + + K
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV---K 895
Query: 1097 ETKLTFEMNIPKTEGMIISS-TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
+ + + E ++ + M++D + L E+
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK 955
Query: 1156 VLQ---EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+L+ E + K + E++E KI LE E T ++ ++++ +K E L D
Sbjct: 956 LLESKLESTLKKSLEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADFQKTEHELRVQLSAFESKYEQ 1270
+ + IS ++ E E ++ L R + ++ L+ + A +++ +Q
Sbjct: 1014 --ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
Query: 1271 L---LDSVQSSTQEETNKIVTM-EQVTSLQN---KLQDKEEHLRNLQEKYADVINQIEIL 1323
L +++Q+ + V++ EQ T+LQ KLQ + L + + Q+ I
Sbjct: 1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131
Query: 1324 RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXX 1383
+S +E+E + D + + + Q ++ ++ LK +
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQASEYESLISKHGTLKSAHKN 1190
Query: 1384 XXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVE 1443
R N ++L+ QLE D E K + + L +N E + +
Sbjct: 1191 LEVEHRDLEDRYN----QLLKQKGQLE--DLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244
Query: 1444 YEKRIEDLTYE---KESELAIL---RLKMHENANHYETMQKESEIERVK-LIEELNVKIT 1496
E + TY KE+E+ LK N + E + E+E ++K ++L++ T
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
Query: 1497 ESVSLNKQVAELNKALEEE 1515
+ + + +++L LEEE
Sbjct: 1305 KLNNQCELLSQLKGNLEEE 1323
Score = 106 bits (255), Expect = 6e-22
Identities = 181/868 (20%), Positives = 388/868 (44%), Gaps = 72/868 (8%)
Query: 295 LAKQSIEPSCEE-KTEIE--EKGSLEIANMTE----LTKKIELLEHLNCQIRQT------ 341
+ QS+ + EE +T ++ E + +I M + L+KK+E+LE+ Q +Q+
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 342 -NKELENKLATMGTESKAVSSPSKKGSPLISRKSG--RNTASKMKSPWSQLSSETLNQDT 398
+K+L + A + + + S++ ++ +++ T S ++ SQ+S+E +D
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR-SQISAEARVKDI 585
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
+K+ NK ++ L+K +K + E + ++ L LE +
Sbjct: 586 EKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL---HHLEKEN 641
Query: 459 HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLN 516
+ + ++ E + + + +L++E N ++K + K+L +L+S E++ +QL+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQ---KTIDNFSKVSDSNKEIVRLT-EELHHLSQKVA 572
+E +N+ +K +K+ Q+Q K +++ + E+++ + ++ L
Sbjct: 701 EENLELRRNVESLKC-ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 573 ELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMEN-LAETRLKAISLLESQKFDLVQEL 630
L+ E LQ L + + + +ES++ + +EMEN + L+ + + + L +E
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESEL--QDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 631 HILQQKYDEVE-DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L+Q+ ++E DK + + + +EIK LEE + +KE + + + + K
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL--EKMSAEKISELLAKINHE-EQSK 746
E +K+LE + ++++ + I+ + L + L EK+ ++++ L K+ HE E+
Sbjct: 878 ESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 747 IQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
+ + + + D + +ES+L S K + EE IA +E R QL
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
Query: 806 LQEKQKAYSEYTIQEDE--LVNRLAVLMDHDRVVE-------KQLLEIEHENKELQKKNQ 856
L+ +K Y ++DE +V + D E ++LL+++ E+++ N
Sbjct: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
Query: 857 ILLEENQNLQISLSDMQQHYNAL----VEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
L E Q L+ L ++ N L + +T + ++T QTQ L+ + +
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL-N 1115
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL----EAQLQEYK 968
T ++ + ++ + + ES I++++ L Y+ I+ +L E Q EY+
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 969 NNIE---NLNMNVEELNKMNLELIDKHVQ--KQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+ I L + L + +L D++ Q KQ+ Q D + E K+ LL+ K+
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM--LLENKNH 1233
Query: 1024 EIIAL--------NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
E +A N ++N+ + ++ + L N + E R+ + K
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFE 1103
+ ++L I + ++Q + L + K E
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLE 1321
Score = 105 bits (253), Expect = 1e-21
Identities = 193/906 (21%), Positives = 386/906 (42%), Gaps = 77/906 (8%)
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSK 746
++ L + D + + +L+ ++ +D +LE+M E ++ + + + +S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+ +DA ++E+ + ++ +ESE+S+YK R+ +E A +E E K D L
Sbjct: 306 RMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVE------ELKEDN--QVL 356
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
E + + ++L L + ++ +L ++E E +KK + L+EEN L+
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 867 ISLS---DMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESN-LKRITHEHQTLI--V 919
++ D H +E+ +RT +L+E+ ++ +L S+ L ++ E+Q+L V
Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 920 QKKKEIEDLEIEFN-TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN--------- 969
++ + D +E N ++I ++ + L++K E + Q + LQ +N
Sbjct: 477 EELRTTVD-SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 970 -----NIENLNMNVEELNKMNLELIDKH----VQKQQTQSPDYTEQYINEINKLNALLKQ 1020
IE L N E K+ LE ++H V + +S E + +I K N +L +
Sbjct: 536 AQLEKTIETLRENSERQIKI-LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE 594
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
+E + KI + + Y+ K + +L ++E+E + + K++ + K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E+++ L +E + +E ++ K T + + + S E D N++
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLD-SFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ---- 1193
+K+ + + E L+ + +L L+ + E L G D+ NQ
Sbjct: 714 KCASMKMAQLQ---LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 1194 ------EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
++I QL+S+L+ L EN L + EL+ S S ++Q E L +Q +Q E
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL-EQETSQLE 828
Query: 1248 ADFQKTEHE---LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN--KLQDK 1302
D ++ E E LR Q ++ E+ ++V+ E+ NK ++ E ++ +L++
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEE--NNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
E+ + L ++ I + LR ++ EK+ + N+
Sbjct: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLK--TQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
EQS + + + K S ++ EA++ E T+ + E+
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEE-KIAALEARLEESTNYNQQLRQELKTVKKN 1003
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRI--EDLTYEKESELAILRL-KMHENANHYETMQKE 1479
Y L QR DE +++V+ I ED +E+ES+ L K+ + E
Sbjct: 1004 YE-ALKQRQDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ E+ L +L T++ +L Q+ L + + +QT ++E TLN +
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 1540 ITNLQN 1545
T+L N
Sbjct: 1118 STSLMN 1123
Score = 98.3 bits (234), Expect = 2e-19
Identities = 158/809 (19%), Positives = 336/809 (41%), Gaps = 68/809 (8%)
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+Q I+ ++ L+++ + E ++ I L E + ++ GS +
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ ++ +++ + ++ L +QLL+ + E ++++ + + L +EN NL
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 869 LSDMQQH---YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ + +AL EKA R D ESE ++Y+ +L D+E R V++ KE
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR---------VEELKED 352
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN 985
+ +E T +E + + ++K + + QL+A+L + + + +EEL + N
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 986 LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD 1045
+ L + QKQ + + +I++ + L + + +L ++N S + +
Sbjct: 413 MTL--EMAQKQSMDESLHLGWELEQISRTSELSEAPQK---SLGHEVNELTSSRLLKLEM 467
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN 1105
L + +L + ++ + ++L ++ N+ L V +++I + K++ L N
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS-LQNCQN 526
Query: 1106 IPK---TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA 1162
+ K E + TIE + +++ + QE E Q S L+++S
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSER-----------QIKILEQENEHLNQTVSSLRQRS- 574
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
+++ E ++ +E N L E I + SKL ++ E + + +
Sbjct: 575 QISAE-----ARVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
+R E+ E HL + QK L++ E+ L+ S + E
Sbjct: 623 K-----GERAEEL-ENELHHLEKENELLQKKITNLKITCEKIEA-----LEQENSELERE 671
Query: 1283 TNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR-SEIEDEKVAFXXXXXX 1340
K+ T++ +L +L+ E+ L E+ ++ +E L+ + ++ ++
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
+L + + E S ++ EN +L+K+ + D E
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 1401 KVLELTHQL-ELK-DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ L L ELK S+ ++ + +L Q + E ++QL + KR+ K++
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 1459 LAILRLKMHENANHYETMQKESEI-----ERVKLIEELNVKITESVSLN-KQVAELNKAL 1512
L +K+ +T+ KE I R+K +E+ N ++ + +++ K + L + L
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 1513 EEEVAKTNEMQTALE--NQEIEIVTLNDE 1539
E KT +M LE E+E + LN E
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 93.5 bits (222), Expect = 6e-18
Identities = 178/885 (20%), Positives = 369/885 (41%), Gaps = 72/885 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIE--SKDVRISSLEEANKLLEAARFEISLE 270
+T ++ ++ Q + E E ++ L+ S + R+ +E+ NK+L + E S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
SK+ E E+ + +E + E +I N+ +KIE
Sbjct: 603 LSKI--EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK-SGRNTASKMKSPWSQL 389
LE N ++ + N++L+ L + + + S K+ S L R +K ++
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 390 SSETLNQDTDKKINKNEIAK-LEMVIQSLNK-DLVDKEYVISEKDTXXXXXXXXXXGKDT 447
+ L ++ + + K ++ K LE++ S K + ++ Y D +
Sbjct: 721 AQLQL-ENKELESEKEQLKKGLELLKASFKKTERLEVSY--QGLDIENQRLQKTLENSNK 777
Query: 448 LIAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK 506
I QL+ E Q ME +L N E++ +K EQL++E K
Sbjct: 778 KIQQLESELQDLEMENQTL---QKNLEELKISSKRLEQLEKE----------------NK 818
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
S E++ +QL + K +++ ++K ++ +N K+ + KE L++E+
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE---ENNVKIGNLEKENKTLSKEIGI 875
Query: 567 LSQKVAELEE-EKGNLQL---HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
+ L+E EK N +L +D + + D+ + ++ + + K LE
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS-EIKSVHLEEQIDALSASKKELALV 681
+ + LH +Q D+ KL + S+L+S S EIK EE+I AL A +E
Sbjct: 936 GLNKERLLHD-EQSTDDSRYKLLE-SKLESTLKKSLEIK----EEKIAALEARLEESTNY 989
Query: 682 IENLKLDKEQL---YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ L+ + + + Y +K ++++ + + ++N K E+ S E ELL K
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN-----KWERESQETTRELL-K 1043
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ + + A+ Q ++ +E++ + +++I L+ ++++ +L+ +
Sbjct: 1044 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1103
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+L Q S Q L+N+ A L+ +E + + E ++L+ L
Sbjct: 1104 NAKL-------QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+++++ L++ Y +L+ K A L D + L + + + L
Sbjct: 1157 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1216
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ--LQEYKNNIENLNM 976
K E E + +E A KK+ E N Y L+ LQ N+++L +
Sbjct: 1217 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL-L 1275
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE----INKLNALLKQKDEEIIALNQ-- 1030
N +L + LE + K+Q Q D T +N +++L L++++ ++ Q
Sbjct: 1276 NNSKLEQTRLE-AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334
Query: 1031 KINNAQVSYMSMVSD--YESKLAQFTTKLENMEEEMQRVSKQLLD 1073
+ N + +M S + + Q+ KL + + +++ ++++D
Sbjct: 1335 MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
>AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein
protein.
Length = 1843
Score = 134 bits (325), Expect = 2e-30
Identities = 227/1096 (20%), Positives = 448/1096 (40%), Gaps = 75/1096 (6%)
Query: 475 VNEIAKVQEQLKQELND-EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
V+++ + K+ L+D E V++L E + E T L D+++ K+
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
K L+ K D + K+I L EE L + +E +L L
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 594 IESDVYKKM-IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
+ K + E+ L +RL LE + L + + L+ D VE + I +++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLK---LEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
+ K LE +I S + + ++L +K QL TI+ L + E + L+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE- 557
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKI--QTQFGIDAKIQERDLYIENIES 769
QEN L + + A++ E+++KI ++ +K+ + + I+
Sbjct: 558 --QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 770 ELSKYKS---RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL YK R LE + +E L++K L EK +A + + + +
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQENSELERENRK 674
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
L +D + + QL +E EN +L ++N L ++L+ + M Q ++ N+
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-----LQLENKE 729
Query: 887 DLAESESTKYQTQLRDLE-SNLKRITHEHQTLIVQKKKEIEDLEIEFNT--QIESAIRDK 943
+E E K +L +R+ +Q L ++ ++ + LE Q+ES ++D
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ-KQQTQSPD 1002
++ N+ +KN+E + +L++ + ++L +L K +L ++ + +QQ + D
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 1003 YTEQY----INEINKLNALLKQK----DEEIIALNQK-------INNAQVSYMSMVSDYE 1047
T + I + K N L ++ E + L + + A + ++V+ E
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKL--TFEMN 1105
+++ K + M ++++++ +L + E L + DD +L E+KL T + +
Sbjct: 910 DLVSE-KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 1106 IPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKV-QEEEEFIQERSVLQEQSA 1162
+ E I + + +E ++ + LK Q+EE +Q + +
Sbjct: 969 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
K E QE ++++++ E+ ++ Q + LK++L+QL T+N+NL + + L+
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1088
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
S +Q L + A Q L Q ++ ++ QLL S E
Sbjct: 1089 QTVSLQEQ---------NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
+ I E + SL + L E L L E+ A ++ E L S+ K A
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHERQA---SEYESLISKHGTLKSAHKNLEVEHR 1196
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
L+ + Q + +++ +L + +E L+ + ND
Sbjct: 1197 DLEDRYNQLLKQKGQ-LEDLEK--MLKVEQEKMLLENKNHETVAAEYKKLCGENDR---- 1249
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
L T+ LK++E+ Q H+ +L N + E R + E+ K E+ +L I
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLL-NNSKLEQTRLE-AEFSK-----LKEQYQQLDIT 1302
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE----VAK 1518
K++ ++ E E L++++ + ++ +L +Q E E + K
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 1519 TNEMQTALENQEIEIV 1534
NE++ E E +I+
Sbjct: 1363 LNELRRQKEKLEEKIM 1378
Score = 112 bits (269), Expect = 1e-23
Identities = 226/1099 (20%), Positives = 472/1099 (42%), Gaps = 95/1099 (8%)
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
AK++ +L+QEL + K + D ++L+ E ++ +L E N N++ + ++
Sbjct: 258 AKIR-RLRQELEE--KTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRD 310
Query: 539 QMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL------HLVDYDSGR 592
++ + +V E+ R E LH + A +EE K + Q+ L D G
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 593 MIESDVYKKMIEMENL-AETRLKAISL---LESQKF-DLVQELHILQ----QKYDEVEDK 643
SD + +E ENL + +L + + ++ +K +L++E L+ Q DE
Sbjct: 371 RARSDKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 644 LADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK--EQLYGTIKDLEN 701
++ Q+ SE L +++ L++S+ L L +EN L K E+L T+ +E
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS------KIQTQFGIDA 755
+ I+ K++ +EN L+ K+E + E + E + N + S K Q + I+
Sbjct: 489 NASKIL-KME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY-SLERKADQLGSYLQEKQKAYS 814
+ + I+ +E E + L + + + R +E++ L ++E S
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ- 873
+ ++ ++ L +H + ++ E+E+E L+K+N++L ++ NL+I+ ++
Sbjct: 605 KIEFEKRQIKKEL----EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 874 -QHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTL--IVQKKK----EI 925
+ N+ +E+ NR +S K T QL LE ++ E+ L V+ K ++
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 926 EDLEIEFNTQIESAIRDKK----VLNEKYEK--NIEYVTQ-LEAQLQEYKNNIENLNMNV 978
L++E N ++ES K +L ++K +E Q L+ + Q + +EN N +
Sbjct: 721 AQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
Query: 979 EELNK--MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
++L +LE+ ++ +QK + + + + ++ K N L+Q+ ++ +++
Sbjct: 780 QQLESELQDLEMENQTLQK-NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
++ L + K+ N+E+E + +SK++ K+ L+ L +E + + K
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV---K 895
Query: 1097 ETKLTFEMNIPKTEGMIISS-TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
+ + + E ++ + M++D + L E+
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK 955
Query: 1156 VLQ---EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+L+ E + K + E++E KI LE E T ++ ++++ +K E L D
Sbjct: 956 LLESKLESTLKKSLEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADFQKTEHELRVQLSAFESKYEQ 1270
+ + IS ++ E E ++ L R + ++ L+ + A +++ +Q
Sbjct: 1014 --ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
Query: 1271 L---LDSVQSSTQEETNKIVTM-EQVTSLQN---KLQDKEEHLRNLQEKYADVINQIEIL 1323
L +++Q+ + V++ EQ T+LQ KLQ + L + + Q+ I
Sbjct: 1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131
Query: 1324 RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXX 1383
+S +E+E + D + + + Q ++ ++ LK +
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQASEYESLISKHGTLKSAHKN 1190
Query: 1384 XXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVE 1443
R N ++L+ QLE D E K + + L +N E + +
Sbjct: 1191 LEVEHRDLEDRYN----QLLKQKGQLE--DLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244
Query: 1444 YEKRIEDLTYE---KESELAIL---RLKMHENANHYETMQKESEIERVK-LIEELNVKIT 1496
E + TY KE+E+ LK N + E + E+E ++K ++L++ T
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
Query: 1497 ESVSLNKQVAELNKALEEE 1515
+ + + +++L LEEE
Sbjct: 1305 KLNNQCELLSQLKGNLEEE 1323
Score = 106 bits (255), Expect = 6e-22
Identities = 181/868 (20%), Positives = 388/868 (44%), Gaps = 72/868 (8%)
Query: 295 LAKQSIEPSCEE-KTEIE--EKGSLEIANMTE----LTKKIELLEHLNCQIRQT------ 341
+ QS+ + EE +T ++ E + +I M + L+KK+E+LE+ Q +Q+
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 342 -NKELENKLATMGTESKAVSSPSKKGSPLISRKSG--RNTASKMKSPWSQLSSETLNQDT 398
+K+L + A + + + S++ ++ +++ T S ++ SQ+S+E +D
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR-SQISAEARVKDI 585
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
+K+ NK ++ L+K +K + E + ++ L LE +
Sbjct: 586 EKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL---HHLEKEN 641
Query: 459 HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLN 516
+ + ++ E + + + +L++E N ++K + K+L +L+S E++ +QL+
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQ---KTIDNFSKVSDSNKEIVRLT-EELHHLSQKVA 572
+E +N+ +K +K+ Q+Q K +++ + E+++ + ++ L
Sbjct: 701 EENLELRRNVESLKC-ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 573 ELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMEN-LAETRLKAISLLESQKFDLVQEL 630
L+ E LQ L + + + +ES++ + +EMEN + L+ + + + L +E
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESEL--QDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 631 HILQQKYDEVE-DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L+Q+ ++E DK + + + +EIK LEE + +KE + + + + K
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL--EKMSAEKISELLAKINHE-EQSK 746
E +K+LE + ++++ + I+ + L + L EK+ ++++ L K+ HE E+
Sbjct: 878 ESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 747 IQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
+ + + + D + +ES+L S K + EE IA +E R QL
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
Query: 806 LQEKQKAYSEYTIQEDE--LVNRLAVLMDHDRVVE-------KQLLEIEHENKELQKKNQ 856
L+ +K Y ++DE +V + D E ++LL+++ E+++ N
Sbjct: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
Query: 857 ILLEENQNLQISLSDMQQHYNAL----VEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
L E Q L+ L ++ N L + +T + ++T QTQ L+ + +
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL-N 1115
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL----EAQLQEYK 968
T ++ + ++ + + ES I++++ L Y+ I+ +L E Q EY+
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 969 NNIE---NLNMNVEELNKMNLELIDKHVQ--KQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+ I L + L + +L D++ Q KQ+ Q D + E K+ LL+ K+
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM--LLENKNH 1233
Query: 1024 EIIAL--------NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
E +A N ++N+ + ++ + L N + E R+ + K
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFE 1103
+ ++L I + ++Q + L + K E
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLE 1321
Score = 105 bits (253), Expect = 1e-21
Identities = 193/906 (21%), Positives = 386/906 (42%), Gaps = 77/906 (8%)
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSK 746
++ L + D + + +L+ ++ +D +LE+M E ++ + + + +S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+ +DA ++E+ + ++ +ESE+S+YK R+ +E A +E E K D L
Sbjct: 306 RMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVE------ELKEDN--QVL 356
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
E + + ++L L + ++ +L ++E E +KK + L+EEN L+
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 867 ISLS---DMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESN-LKRITHEHQTLI--V 919
++ D H +E+ +RT +L+E+ ++ +L S+ L ++ E+Q+L V
Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 920 QKKKEIEDLEIEFN-TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN--------- 969
++ + D +E N ++I ++ + L++K E + Q + LQ +N
Sbjct: 477 EELRTTVD-SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 970 -----NIENLNMNVEELNKMNLELIDKH----VQKQQTQSPDYTEQYINEINKLNALLKQ 1020
IE L N E K+ LE ++H V + +S E + +I K N +L +
Sbjct: 536 AQLEKTIETLRENSERQIKI-LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE 594
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
+E + KI + + Y+ K + +L ++E+E + + K++ + K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E+++ L +E + +E ++ K T + + + S E D N++
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLD-SFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ---- 1193
+K+ + + E L+ + +L L+ + E L G D+ NQ
Sbjct: 714 KCASMKMAQLQ---LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 1194 ------EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
++I QL+S+L+ L EN L + EL+ S S ++Q E L +Q +Q E
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSL-EQETSQLE 828
Query: 1248 ADFQKTEHE---LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN--KLQDK 1302
D ++ E E LR Q ++ E+ ++V+ E+ NK ++ E ++ +L++
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEE--NNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
E+ + L ++ I + LR ++ EK+ + N+
Sbjct: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLK--TQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
EQS + + + K S ++ EA++ E T+ + E+
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEE-KIAALEARLEESTNYNQQLRQELKTVKKN 1003
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRI--EDLTYEKESELAILRL-KMHENANHYETMQKE 1479
Y L QR DE +++V+ I ED +E+ES+ L K+ + E
Sbjct: 1004 YE-ALKQRQDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ E+ L +L T++ +L Q+ L + + +QT ++E TLN +
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 1540 ITNLQN 1545
T+L N
Sbjct: 1118 STSLMN 1123
Score = 98.3 bits (234), Expect = 2e-19
Identities = 158/809 (19%), Positives = 336/809 (41%), Gaps = 68/809 (8%)
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+Q I+ ++ L+++ + E ++ I L E + ++ GS +
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ ++ +++ + ++ L +QLL+ + E ++++ + + L +EN NL
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 869 LSDMQQH---YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ + +AL EKA R D ESE ++Y+ +L D+E R V++ KE
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR---------VEELKED 352
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN 985
+ +E T +E + + ++K + + QL+A+L + + + +EEL + N
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 986 LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD 1045
+ L + QKQ + + +I++ + L + + +L ++N S + +
Sbjct: 413 MTL--EMAQKQSMDESLHLGWELEQISRTSELSEAPQK---SLGHEVNELTSSRLLKLEM 467
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN 1105
L + +L + ++ + ++L ++ N+ L V +++I + K++ L N
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS-LQNCQN 526
Query: 1106 IPK---TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA 1162
+ K E + TIE + +++ + QE E Q S L+++S
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSER-----------QIKILEQENEHLNQTVSSLRQRS- 574
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
+++ E ++ +E N L E I + SKL ++ E + + +
Sbjct: 575 QISAE-----ARVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
+R E+ E HL + QK L++ E+ L+ S + E
Sbjct: 623 K-----GERAEEL-ENELHHLEKENELLQKKITNLKITCEKIEA-----LEQENSELERE 671
Query: 1283 TNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR-SEIEDEKVAFXXXXXX 1340
K+ T++ +L +L+ E+ L E+ ++ +E L+ + ++ ++
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
+L + + E S ++ EN +L+K+ + D E
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 1401 KVLELTHQL-ELK-DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ L L ELK S+ ++ + +L Q + E ++QL + KR+ K++
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 1459 LAILRLKMHENANHYETMQKESEI-----ERVKLIEELNVKITESVSLN-KQVAELNKAL 1512
L +K+ +T+ KE I R+K +E+ N ++ + +++ K + L + L
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 1513 EEEVAKTNEMQTALE--NQEIEIVTLNDE 1539
E KT +M LE E+E + LN E
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 93.5 bits (222), Expect = 6e-18
Identities = 178/885 (20%), Positives = 369/885 (41%), Gaps = 72/885 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIE--SKDVRISSLEEANKLLEAARFEISLE 270
+T ++ ++ Q + E E ++ L+ S + R+ +E+ NK+L + E S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
SK+ E E+ + +E + E +I N+ +KIE
Sbjct: 603 LSKI--EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK-SGRNTASKMKSPWSQL 389
LE N ++ + N++L+ L + + + S K+ S L R +K ++
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 390 SSETLNQDTDKKINKNEIAK-LEMVIQSLNK-DLVDKEYVISEKDTXXXXXXXXXXGKDT 447
+ L ++ + + K ++ K LE++ S K + ++ Y D +
Sbjct: 721 AQLQL-ENKELESEKEQLKKGLELLKASFKKTERLEVSY--QGLDIENQRLQKTLENSNK 777
Query: 448 LIAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK 506
I QL+ E Q ME +L N E++ +K EQL++E K
Sbjct: 778 KIQQLESELQDLEMENQTL---QKNLEELKISSKRLEQLEKE----------------NK 818
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
S E++ +QL + K +++ ++K ++ +N K+ + KE L++E+
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE---ENNVKIGNLEKENKTLSKEIGI 875
Query: 567 LSQKVAELEE-EKGNLQL---HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
+ L+E EK N +L +D + + D+ + ++ + + K LE
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS-EIKSVHLEEQIDALSASKKELALV 681
+ + LH +Q D+ KL + S+L+S S EIK EE+I AL A +E
Sbjct: 936 GLNKERLLHD-EQSTDDSRYKLLE-SKLESTLKKSLEIK----EEKIAALEARLEESTNY 989
Query: 682 IENLKLDKEQL---YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ L+ + + + Y +K ++++ + + ++N K E+ S E ELL K
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN-----KWERESQETTRELL-K 1043
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ + + A+ Q ++ +E++ + +++I L+ ++++ +L+ +
Sbjct: 1044 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1103
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+L Q S Q L+N+ A L+ +E + + E ++L+ L
Sbjct: 1104 NAKL-------QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+++++ L++ Y +L+ K A L D + L + + + L
Sbjct: 1157 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1216
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ--LQEYKNNIENLNM 976
K E E + +E A KK+ E N Y L+ LQ N+++L +
Sbjct: 1217 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL-L 1275
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE----INKLNALLKQKDEEIIALNQ-- 1030
N +L + LE + K+Q Q D T +N +++L L++++ ++ Q
Sbjct: 1276 NNSKLEQTRLE-AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334
Query: 1031 KINNAQVSYMSMVSD--YESKLAQFTTKLENMEEEMQRVSKQLLD 1073
+ N + +M S + + Q+ KL + + +++ ++++D
Sbjct: 1335 MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
>AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb
protein.
Length = 1939
Score = 133 bits (321), Expect = 6e-30
Identities = 227/1132 (20%), Positives = 469/1132 (41%), Gaps = 90/1132 (7%)
Query: 471 NTEDVNEIAKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+ E E+A ++E+ ++ + K + K+L EK+ + ++ L ++ A +
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905
Query: 530 KS--NHKLKLK-QMQKTIDNFSKVSDSNKEI-VRLTEELHHLSQKVAELEEEKGNLQLHL 585
+ + +K K Q++ I ++ ++ +EI LT + L + +EL+++ +L+L L
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 586 VDYDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + + K + E M L ET I+ L +K L QE H QQ D++
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDET----IAKLTKEKKAL-QEAH--QQTLDDL---- 1014
Query: 645 ADISQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK 703
Q++ D+V + K+ LE+Q+D L S ++ + +L+ K +L G +K +
Sbjct: 1015 ----QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
D N Q L +KL+K E +S L KI E+ +Q Q KI+E
Sbjct: 1071 MDTENDKQQ-------LNEKLKKKEFE-MSNLQGKIEDEQALAMQLQ----KKIKELQAR 1118
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG----SYLQEKQKAYSEYTIQ 819
IE +E E+ ++ + E+ + + + + ++ G + ++ +K +E+
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEFQKM 1178
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
+L + H+ + EL K+ L Q L+ S+++ N L
Sbjct: 1179 RRDLEEST---LQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDL 1235
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQI 936
A++ K L D S +K E Q LI + +K + EF+ Q+
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQL 1295
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
+ L+ + + + +L+ QL+E + ++ + + + + +L+ + +++
Sbjct: 1296 DEKDAMVSQLSRGKQAFTQQIEELKRQLEE-ETKAKSTLAHALQSARHDCDLLREQYEEE 1354
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
Q + ++ +++ N A + K E + I +++ A+ + D E + +
Sbjct: 1355 QEAKAEL-QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413
Query: 1056 KLENMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
K ++E+ QR+ + ++D ++ N L ++Q + K L E K +E + E
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEA 1473
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
S +S + V LK +E + QE S L EQ A+ + E
Sbjct: 1474 SQKES--RSLSTELFKVKNAYEESLDHLETLK-RENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
QL+ +EL Q + + ++ LE + + + +++S I + ++
Sbjct: 1531 EKVKKQLDHEKSEL-------QTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEK 1583
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYEQLLDSVQSSTQEETNKIV-T 1288
E+ +L + HL E+ + E+R + A + K E L+ ++ +
Sbjct: 1584 DEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEA 1643
Query: 1289 MEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIEDEKVAFXXX---- 1337
+ + + Q L+D + HL +L+E+ A V + ++++E+E+ + +
Sbjct: 1644 LRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGR 1703
Query: 1338 --XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
L T+N S +++ +I++ +++ +
Sbjct: 1704 KMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAI 1763
Query: 1396 NDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRI 1448
DA EL + + E +K E T+ L R E E + ++Q+ + E R+
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLGEAEQLALKGGKKQIQKLEARV 1823
Query: 1449 EDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKI-TESVSLN 1502
+L E ESE A+ L+ HE T Q E + + + +++L K+ T+ +
Sbjct: 1824 RELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYK 1883
Query: 1503 KQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+Q E + +AK ++Q LE E ++ L+ R +K+
Sbjct: 1884 RQAEEAEEQSNVNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1935
Score = 101 bits (242), Expect = 2e-20
Identities = 204/1106 (18%), Positives = 443/1106 (40%), Gaps = 71/1106 (6%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ E ++ E K LE + E + L +++
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 907 ERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRN-TASKMKSPWSQLSSETLNQDTDKKINKNEIA 408
A + E A + K L +G + T +K+ L D ++ ++++
Sbjct: 966 AKVEKEKHATENKVKN---LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN 1022
Query: 409 KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
L L + + D E + ++ D A+ +LE + S +
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLC---------MDLERAKRKLEGDLKLAQESTMDT 1073
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVN--VKDLIEKLKSAEEQITQLNDEIDAANKNM 526
+ + +NE K +E L +I+D L +K+K + +I +L +EI+A +
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K + +++++ + + + + L ++ QK+ + E+ LQ H
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEFQKMRR-DLEESTLQ-HEA 1191
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ R +D + E+ ++ + LE +K +L E++ L + V A+
Sbjct: 1192 TAAALRKKHAD---SVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKAN 1248
Query: 647 ISQL---QSDQVCSEIKSVHLEEQ--IDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
++ DQ+ SEIK+ E+Q I+ LSA K L ++ + L
Sbjct: 1249 FEKMCRTLEDQL-SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 702 DKEDI---MNKLQNYIQENMDLTDKLEK--MSAEKISELLAKINHEEQ-SKIQTQFGIDA 755
K+ + +L+ ++E L SA +LL + EEQ +K + Q G+
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAV-MEDRRYSLERKADQLGSYLQEKQKAYS 814
E + E++ + + ++ +A ++D +E + S + KQ+ +
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Query: 815 EY--TIQEDELVNRLAVLMD-HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
E + + E N + +D R +K L E + + +E Q + + +E+++L L
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
++ NA E + + + E+ Q ++ DL + +H + + KK+++ + E
Sbjct: 1488 VK---NAYEESLDHLETLKRENKNLQQEISDLTEQIAE-GGKHIHELEKVKKQLDHEKSE 1543
Query: 932 FNTQIESA-----IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
T +E A + K+L + E N + ++++ ++ E ++ L N + +
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELN-QVKSEIDRKIAEKDEELDQLKRNHLRVVESMQ 1602
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+D + + + + ++ ++N++ L + + + + N Q ++ D
Sbjct: 1603 STLDAEI-RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQ----GILKDT 1657
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKL---TFE 1103
+ L ++++E++ V ++ + EEL+ + E+ ++ +++ E +L +
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL-ERTERGRKMAEQELLDASER 1716
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK 1163
+ + T+ + +T + + D + + VQE ++ +A
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDI--------VQEARNAEEKAKKAITDAAM 1768
Query: 1164 LNTELQECYTKIIQLETL--NTELTGHDV-VNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
+ EL++ LE + N E T D+ + + QL L+ + L + V EL
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLGEAEQL--ALKGGKKQIQKLEARVREL 1826
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV-QLSAFESKYEQLLDSVQSST 1279
S + S + L K +E +Q E + +L K + + + +
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQA 1886
Query: 1280 QE-ETNKIVTMEQVTSLQNKLQDKEE 1304
+E E V + + LQ++L++ EE
Sbjct: 1887 EEAEEQSNVNLAKFRKLQHELEEAEE 1912
Score = 97.9 bits (233), Expect = 3e-19
Identities = 157/788 (19%), Positives = 327/788 (41%), Gaps = 61/788 (7%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + +++L + E + KEL++K L++E +LQ+ +Q +
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEAD 900
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
AL + R D + + +++++ + E + KK+++ED E I+
Sbjct: 901 ALADAEERCDQLIKTKIQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDID 959
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEED 1019
Query: 995 KQQTQSPDYT--EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T + T EQ ++++ K+ ++ +K+ D E+ Q
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ 1079
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KL+ E EM + ++ D + +LQ ++E +I+EL+E + K E
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 1113 --IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ L + E EF + R L+E + L E
Sbjct: 1140 RSDLSRELEEISERLEE----AGGATSAQIELNKKREAEFQKMRRDLEEST--LQHEATA 1193
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
+ +++ EL G + + + ++K KLE+ +E ++ +A ++S A +
Sbjct: 1194 AALRKKHADSV-AEL-GKQI---DSLQRVKQKLEKEKSELKMEINDLASNMETVSKA--K 1246
Query: 1231 RGFE-IAELWKQHLAQ---READFQKTEHELRVQ---LSAFESKYEQLLDSVQSS-TQEE 1282
FE + + L++ +E + Q+ +EL Q L ++ + LD + +Q
Sbjct: 1247 ANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLS 1306
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
K +Q+ L+ +L+++ + L + ++LR + E+E+ A
Sbjct: 1307 RGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEA--------K 1358
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
+E ++ E + EE + KK VN A +
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418
Query: 1403 LELTHQL--ELKDSEI-YQKTHEYTITLTQRNDEFENV----RQQLVEYEKRIEDLTYEK 1455
+ +L E++D I ++++ I L ++ F+ V +Q+ E + +E E
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKES 1478
Query: 1456 ES---ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
S EL ++ E+ +H ET+++E++ + I +L +I E K + EL K
Sbjct: 1479 RSLSTELFKVKNAYEESLDHLETLKRENK-NLQQEISDLTEQIAEG---GKHIHELEKVK 1534
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
++ + +E+QT+LE E + +I +Q + S+I + ++ +DE+L
Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIA-------EKDEEL 1587
Query: 1573 DNTMNKEL 1580
D L
Sbjct: 1588 DQLKRNHL 1595
Score = 96.3 bits (229), Expect = 8e-19
Identities = 196/1001 (19%), Positives = 425/1001 (42%), Gaps = 82/1001 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D++ ++ ++++L +A LE E SLE
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLE 1043
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++S + +K ++ EK + M+ L KIE
Sbjct: 1044 QEKKLCMDLERAKRKLEGDLK----LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE 1099
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q+++ KEL+ ++ + E +A ++ S + K + + +++ +L
Sbjct: 1100 DEQALAMQLQKKIKELQARIEELEEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1154
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
E T +I N+ K E Q + +DL +E + + T +
Sbjct: 1155 --EEAGGATSAQIELNK--KREAEFQKMRRDL--EESTLQHEATAAALRKKHADS----V 1204
Query: 450 AQL--QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL-KQELNDEIKDVNVKDLIEKLK 506
A+L Q++ Q ++ ++N++A E + K + N E ++D + ++K
Sbjct: 1205 AELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIK 1264
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
+ EE+ +L +E+ A + +L + + S+ + T+++
Sbjct: 1265 TKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQA------FTQQIEE 1318
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAISLLESQ--K 623
L +++ E + K L L S R + D+ ++ E E A+ L + +S S+ +
Sbjct: 1319 LKRQLEEETKAKSTLAHAL---QSARH-DCDLLREQYEEEQEAKAELQRGMSKANSEVAQ 1374
Query: 624 FDLVQELHILQ--QKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ E +Q ++ +E + KLA Q + V K LE+ L ++L +
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMI 1434
Query: 681 VIEN-----LKLDKEQ--LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM--SAEK 731
+E + LDK+Q + + + E+ +L+ +E+ L+ +L K+ + E+
Sbjct: 1435 DVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE 1494
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYI---ENIESELSKYKSRI-CRLEESIAV 787
+ L + E ++ Q + +I E +I E ++ +L KS + LEE+ A
Sbjct: 1495 SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
+E + R +L E + +E +DE +++L +H RVVE ++
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAE----KDEELDQLK--RNHLRVVESMQSTLD-- 1606
Query: 848 NKELQKKNQILLEENQNLQISLSDMQ---QHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E++ +N L + ++ L++M+ H N +A R +L ++ TQL +
Sbjct: 1607 -AEIRSRND-ALRIKKKMEGDLNEMEIQLNHANRQAAEALR-NLRNTQGILKDTQLHLDD 1663
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ 963
+ + + Q +V+++ + E+ E +E R +K+ ++ E V L Q
Sbjct: 1664 AIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQ 1723
Query: 964 LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
N + L ++ ++ E+ D + ++ + + ++ I + + LK++ +
Sbjct: 1724 NTSLINTKKKLETDISQIQG---EMED--IVQEARNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 1024 EIIALNQKINNAQVSYMSM---VSDYES-KLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
L + N + + + + + E L +++ +E ++ + ++ ++HN
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLGEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNV 1838
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +R+ + ++KEL NI + + ++ + + +
Sbjct: 1839 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLA 1898
Query: 1140 XXLKVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLE 1179
K+Q E E +ER+ + + Q KL + +E +TK+I E
Sbjct: 1899 KFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 78.2 bits (184), Expect = 2e-13
Identities = 181/913 (19%), Positives = 383/913 (41%), Gaps = 80/913 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L+ +K+K+ +S LQ K++ + + LQ+KI E IE +
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A A+ + K+R + E + +R LEE+ EA
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIELNKKR---EAEFQKMR-RDLEESTLQHEA 1191
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEEKGS-LEIAN 320
+ +H+ EL + KQ +E E K EI + S +E +
Sbjct: 1192 TAAALRKKHADSVAELGKQIDSLQR--------VKQKLEKEKSELKMEINDLASNMETVS 1243
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR-N 377
+ K LE +I+ +E + + + + + + S + S + K +
Sbjct: 1244 KAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVS 1303
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXX 435
S+ K ++Q E Q ++ K+ +A +QS DL+ ++Y E+
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEETKAKSTLAH---ALQSARHDCDLLREQY--EEEQEAK 1358
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
++ +AQ + +++ TE++ E K Q Q+ + ++
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 496 VNVK-DLIEKLKS-AEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + ++ L +++ +N I K ++ K+ + QK + ++
Sbjct: 1411 VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAE 1470
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL + EE +L+ + + + SD+ +++ E
Sbjct: 1471 LEASQKESRSLSTELFKVKN---AYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHI 1527
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI--KSVHLEEQ 667
K L+ +K +L L + + E K+ I QL+ +QV SEI K +E+
Sbjct: 1528 HELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI-QLELNQVKSEIDRKIAEKDEE 1586
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+D L K+ V+E++ + L I+ ND I K++ + E M++ +L
Sbjct: 1587 LDQL---KRNHLRVVESM---QSTLDAEIRS-RNDALRIKKKMEGDLNE-MEI--QLNHA 1636
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+ + +E L + + + TQ +D I+ +D +++ +L+ + R ++ A
Sbjct: 1637 N-RQAAEALRNLRNTQGILKDTQLHLDDAIRGQD----DLKEQLAMVERRANLMQ---AE 1688
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
+E+ R SLER + G + E++ + +Q L + L++ + +E + +I+ E
Sbjct: 1689 VEELRASLER--TERGRKMAEQELLDASERVQ--LLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
+++ ++ + + + +++D L ++ + + E + ++DL+
Sbjct: 1745 MEDIVQEAR---NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ--- 1798
Query: 908 KRITHEHQTLIVQKKKEIEDLEI---EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
R+ Q + KK+I+ LE E +++ES + + K+ V +L Q
Sbjct: 1799 LRLGEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQT 1858
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+E + NI L V++ L+ K ++Q ++ + + + + KL L++ +E
Sbjct: 1859 EEDRKNILRLQDLVDK-----LQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAEER 1913
Query: 1025 IIALNQKINNAQV 1037
++N +V
Sbjct: 1914 ADIAESQVNKLRV 1926
>X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein.
Length = 1411
Score = 131 bits (317), Expect = 2e-29
Identities = 244/1161 (21%), Positives = 496/1161 (42%), Gaps = 126/1161 (10%)
Query: 477 EIAKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
E+ K E+ + E K D V D +L+S E+Q+ +E N N+ ++K +
Sbjct: 108 ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL----EEAQTENFNIKQMKDLFEQ 163
Query: 536 KLKQMQKTIDNFSKVSDSNK--------EIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
K Q+ I + D + ++ RLTEEL+ + + +L+ E L
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL----LQRPG 219
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
+ +++ ++ + M+N+ R + ES+K L E LQ +Y E A I
Sbjct: 220 IEDVAVLKKELVQVQTLMDNMTLERER-----ESEK--LKDECKKLQSQYASSE---ATI 269
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELA----LVIENLKLDKEQLYGTIKDLENDK 703
SQL+S+ + +++ L +S EL + ENL L KEQ Y +++ N++
Sbjct: 270 SQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL-LKKEQDYTKLEEKHNEE 328
Query: 704 EDIMNKLQNYI-QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDL 762
+Q + Q+++D ++SA + S L +I+ E K + K++E
Sbjct: 329 SVSKKNIQATLHQKDLDCQQLQSRLSASETS--LHRIHVELSEKGEAT----QKLKEE-- 380
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY--TIQE 820
+ +E++ K+ +L++ E L+ + +QL S L E ++ E ++E
Sbjct: 381 -LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE 439
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++ LMD ++ V L++ ++L++K + + LQ L +Q +
Sbjct: 440 QRQLSS-EKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQHQLDKTKQQHQ--- 491
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL-----IVQKKKE----IEDLEIE 931
+ L +S + K + DLE L++I + Q + ++QK KE +E +
Sbjct: 492 ---EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
Query: 932 FNTQIESAIRDKKVLNEKYEKNI---EYVTQLEAQL----QEYKNNIENLNMNVEELNKM 984
+I++ + VLN+ EKN E VTQL +L + +K ENL+ V+E K
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE-QKA 607
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
+L V +T + Q +N+ + Q D +I A + + +A+ + + +
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQ----LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
D ++ L L++ ++E+ +++ QL ++ Q + + +KE KE L+ E
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723
Query: 1105 NIPKTEGMI---------ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ---EEEEFIQ 1152
+ EG I + ++ E D L Q E+E
Sbjct: 724 KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS 783
Query: 1153 ERSVLQEQSAKLNT-----ELQECYTKIIQ--LETLNTEL-TGHDVVNQEQINQLKSKLE 1204
R LQ++S L + QE +I++ ETL+ E H+ +N +I ++L+
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN-NRIQTTVTELQ 842
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA--DFQKT----EHELR 1258
++ E + L++ ++ ++ +S D +E K++ + A D +KT +H+L+
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902
Query: 1259 VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
VQ+ + ++L S++ ++E + + +E + S+Q +L + L+ +++ +
Sbjct: 903 VQMENTLKEQKELKKSLEK--EKEASHQLKLE-LNSMQEQLIQAQNTLKQNEKEEQQLQG 959
Query: 1319 QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLK 1378
I L+ E +K +L + Q Q + E+ + L+
Sbjct: 960 NINELKQSSEQKKKQI-EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVR 1438
+ E+++L L K+ E ++L Q D N R
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDL---------KSVEEKLSLAQ-EDLISN-R 1067
Query: 1439 QQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKI 1495
Q+ K I++L K E + A ++ E + +QKE ++ +L+ E + K+
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS-KL 1126
Query: 1496 TESVSL----NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASS 1551
E + K++ +LN+ L+ ++ + T L++ + ++ E+ + ++A+
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 1552 SKIQKHVSFASDTKQGRDEQL 1572
+ +++ D + +E+L
Sbjct: 1187 EQEKRNQQILKDQVKKEEEEL 1207
Score = 131 bits (317), Expect = 2e-29
Identities = 235/1203 (19%), Positives = 501/1203 (41%), Gaps = 95/1203 (7%)
Query: 388 QLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKD- 446
+ +E N K + + + A+L I + K D+E + E K+
Sbjct: 146 EAQTENFNIKQMKDLFEQKAAQLATEIADI-KSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDLIE 503
T+I L+ E Q P + V +++ ++ + + + ++ ++++KD K L
Sbjct: 205 TVIQDLKTELLQR---PGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD-ECKKLQS 260
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
+ S+E I+QL E+ A + V KLK + ++ N +++ ++
Sbjct: 261 QYASSEATISQLRSEL-AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN--LLKKEQD 317
Query: 564 LHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM------IESDVYKKMIEMENLAETRLKA 615
L +K E K N+Q LH D D ++ E+ +++ +E+ E K
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 616 ---ISLLESQKFDLVQELHILQQKYDEVEDK----LADISQLQSDQVCSE--IKSVH--L 664
+S +E++ L E LQQ+ +E E ++I+QL S + +E + H L
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+EQ S + + +L+L +L +K+ + ++ ++L Q++ + L
Sbjct: 438 KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE-QQAL 496
Query: 725 EKMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL 781
++ + K+ E L ++ + K Q ++A +Q+ I +E E ++I
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 556
Query: 782 EESIAVM---EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E AV+ +++ ++L+ + QL L+ + +++ + ++ L +++ H R +
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ---AQENLHDQVQEQKAHLRAAQ 613
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISL-SDMQQHYNALVEK-ANRTDLAESESTKY 896
++L +E EL + E+ L I + + + +A K A R DL T
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA- 672
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV----LNEKYEK 952
Q L+D + L +IT T + Q +++D + E +Q+ES +++ K L +K E+
Sbjct: 673 QNALQDKQQELNKIT----TQLDQVTAKLQDKQ-EHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 953 NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
+ +LEA E K + E ++++ ++N +L + + T+ E ++
Sbjct: 728 LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL-----ELRATELSKQLEMEKEIVS 782
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
L++K E + ++ QK+ + + D+E+ + + E + +Q +L
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 1073 DSKQHNEELQILVREQDDQIKE----LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV 1128
K E L + D++ + LK +K FE K + I+ +E + +
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD--LEKTCKELKH- 899
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
LK Q+E + E+ +E S +L EL ++IQ + +
Sbjct: 900 ----QLQVQMENTLKEQKELKKSLEKE--KEASHQLKLELNSMQEQLIQAQNTLKQ---- 949
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N+++ QL+ + +L ++ + L+ + AV Q+ E+ +Q L Q
Sbjct: 950 ---NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT-ELENKLQQQLTQAAQ 1005
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
+ + ++ V + +E E E+ + T + + S++ KL +E L +
Sbjct: 1006 ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
+ + NQ ++++ E++ K L+ + Q K ++E+ ++
Sbjct: 1066 NRNQIG---NQNKLIQ-ELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKEKSLKEKELV 1120
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK-VLELTHQLELKDSEIYQKTH-EYTIT 1426
N + A++++ + + + + E+T+ + K I QK +
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 1427 LTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVK 1486
+ E E QQ+++ + + E+ E + E K+H E K+ E K
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEE--EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
Query: 1487 LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
L ++IT +LN+ + + K + + +E++ ++ EI L + N Q+
Sbjct: 1239 ----LTMQIT---ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291
Query: 1547 VRA 1549
RA
Sbjct: 1292 RRA 1294
Score = 120 bits (290), Expect = 3e-26
Identities = 222/1145 (19%), Positives = 477/1145 (41%), Gaps = 110/1145 (9%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRI--SSLEEANKLLEAARFEISL 269
E +Q++T++ E +D K LL+ +DV + L + L++ E
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
E KL E ++ L + + E ++E L+ +++ ELT+K +
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK-SSVNELTQKNQ 305
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
L + Q +LE K K + + + + R +AS+ +
Sbjct: 306 TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+ T K K E++++E Q L + + EK+
Sbjct: 366 ELSEKGEATQKL--KEELSEVETKYQHLKAEFKQLQQQREEKEQHG-------------- 409
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE-LNDEIKDVNVKDLIEKLKSA 508
LQL+ + + L+ + + K Q QL E L D K+ V DL KL
Sbjct: 410 --LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD--KEQQVADLQLKLSRL 465
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS 568
EEQ+ + + K K H+ + Q T +K+ ++ ++ ++ ++
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT---AKLREAQNDLEQVLRQIGDKD 522
Query: 569 QKVAELEE--EKGNLQLHLVDYDSGRMIESDVYKKMI--EMENLAETRLKAIS-LLESQK 623
QK+ LE +K + L++ + D+Y K+ E E +L+ + L+ Q
Sbjct: 523 QKIQNLEALLQKSKENISLLEKE-----REDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSA----SKKEL 678
L ++L + + + ++ L D Q Q + ++ + + LE ++ L++ SK+++
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 679 ALVIENLKLDKEQLYGTIK-------DLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-- 729
+ + +K E L DL+N + N LQ+ QE +T +L++++A
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+ E +++ + + ++ K +E + I+ +E++ + K+ + + +
Sbjct: 698 QDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQR 757
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH--DRVVEKQLLEIEHE 847
LE +A +L L+ +++ S + + L + + EKQ+L+ + E
Sbjct: 758 QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817
Query: 848 NKELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLA--ESESTKYQTQLRDLE 904
L ++ +I EE N +Q +++++Q+ + ++A T+L+ + + +K L++ +
Sbjct: 818 T--LSQETKIQHEELNNRIQTTVTELQKV--KMEKEALMTELSTVKDKLSKVSDSLKNSK 873
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
S ++ + + I+ +K ++L+ + Q+E+ ++++K L + EK E QL+
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL-- 931
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
ELN M +LI +Q + + +Q IN+L +QK ++
Sbjct: 932 ---------------ELNSMQEQLIQAQNTLKQNEKEE--QQLQGNINELKQSSEQKKKQ 974
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
I AL ++ A + + + + +L Q +L +E++ + S++ ++LQ
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
++ ++ ++ + E + + +IS+ N +
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNR--------NQIGNQNKLI--------- 1077
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
+E ++ L++ SAK +LQE + L+ + E + + +E +N+ KSKL
Sbjct: 1078 ---QELKTAKATLEQDSAKKEQQLQE---RCKALQDIQKEKS---LKEKELVNE-KSKLA 1127
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELW--KQHLAQREADFQKTEHELRVQLS 1262
++ + +L + S + EI L KQ L Q++ + Q L+ +
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
E + +Q+L Q +EE K +E+ L +++++KE ++ +E A + QI
Sbjct: 1188 Q-EKRNQQILKD-QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245
Query: 1323 LRSEI 1327
L +
Sbjct: 1246 LNENL 1250
Score = 110 bits (265), Expect = 4e-23
Identities = 205/933 (21%), Positives = 384/933 (41%), Gaps = 72/933 (7%)
Query: 162 QVKMKIMETTILDLQ-EKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQ--- 217
Q+K K+ +T L Q +K ++ Q +A ++TT D Q+
Sbjct: 468 QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 218 ----MTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLE------AARFEI 267
+ K +EN +E E +D ++ E + ++ L+E N L+ + +
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAG-EGETAVLNQLQEKNHTLQEQVTQLTEKLKN 586
Query: 268 SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT-ELTK 326
E K AQE S+E S E + +++ + ++
Sbjct: 587 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
K ELL +L+N L T + K + + + + + +
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK--LQDKQEHC 704
Query: 387 SQLSSETLNQDTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
SQL S L + +K ++ + + +LE I+ L D + E S++
Sbjct: 705 SQLESH-LKEYKEKYLSLEQKTEELEGQIKKLEADSL--EVKASKEQALQDLQQQRQLNT 761
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELN--DEIKDVNVKDLIE 503
D + +L Q ME V + D+ + ++ E +KQ+L +E K + +D
Sbjct: 762 DLELRATELSKQLEMEKEI---VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
+ + Q +LN+ I + KVK + + ++ D SKVSDS K E+
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 564 LHHLSQK-VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
+ + + +LE+ L+ L + E KK +E E A +LK L S
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE--LNSM 936
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQ--SDQVCSEIKSVHLEEQIDALSASKKELAL 680
+ L+Q + L+Q E + +I++L+ S+Q +I+++ E +I L K EL
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ--KTEL-- 992
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
EN KL ++QL ++L +KE I + LQN +++ + +L+ + SELLA
Sbjct: 993 --EN-KL-QQQLTQAAQELAAEKEKI-SVLQNNYEKSQETFKQLQSDFYGRESELLA--T 1045
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
++ ++ + + + DL I N +++ I L+ + A +E E++
Sbjct: 1046 RQDLKSVEEKLSL----AQEDL-ISN-RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+ LQ+ QK E +++E ELVN + L + + + +Q EI N+EL+ ++
Sbjct: 1100 ERCKALQDIQK---EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
E NL+ + + Q L KA+ A + + Q L+D ++ E + L
Sbjct: 1157 EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD------QVKKEEEEL--- 1207
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN----IEYVTQLEAQLQEYKNNIENLNM 976
KKE IE ++ S I++K+V +K+E+N +T L L K ++
Sbjct: 1208 -KKEF----IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262
Query: 977 NVEELNKMNLELIDKHVQKQQT--QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
V EL K +L + + T + D + K +++ +++ L +K++N
Sbjct: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + + +S + T L E V
Sbjct: 1323 TTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355
Score = 104 bits (249), Expect = 3e-21
Identities = 201/1026 (19%), Positives = 439/1026 (42%), Gaps = 102/1026 (9%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
++ T+ +KD LQ ++ ET++ + +++EK EA K
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG---EATQK-LKEELSEVETKYQ 389
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----ANKLL 260
+ +QQ + +++ + +++E +LL+ L+E + KL+
Sbjct: 390 HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 261 EAAR--FEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEI----EEKG 314
+ + ++ L+ S+L ++L++ +Q E +++ E +
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
Query: 315 SLE--IANMTELTKKIELLEHL------NCQIRQTNKE-LENKLATMGTESKAVSSPSKK 365
LE + + + +KI+ LE L N + + +E L K+ E+ ++ +K
Sbjct: 510 DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
Query: 366 GSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKD 420
L + + +N + K L + Q + ++ + LE + LN
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 421 LVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK 480
L + + +S+ D + + + Q H++ + + +++N+I
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD-TAQNALQDKQQELNKITT 688
Query: 481 VQEQLKQELNDEIK-----DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
+Q+ +L D+ + + ++K+ EK S E++ +L +I + ++VK++ +
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 536 KLKQMQK----------TIDNFSKVSDSNKEIVRLT--------EELHHLSQKVAELEEE 577
L+ +Q+ SK + KEIV T E L + QK+ + EEE
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
K Q+ D+++ + + + E+ N +T + + ++ +K L+ EL ++ K
Sbjct: 809 K---QILKQDFET---LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 638 DEVEDKLADI-SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
+V D L + S+ + + + + LE+ L K +L + +EN ++++L
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQMENTLKEQKELK--- 916
Query: 697 KDLENDKE-DIMNKLQ-NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
K LE +KE KL+ N +QE + K + ++ +L IN +QS Q + I+
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS 814
A E + + +K + ++ + + +A +++ L+ ++ ++ Q S
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ---S 1033
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
++ +E EL LA D V EK L + E+ + +NQI NQN L +
Sbjct: 1034 DFYGRESEL---LATRQDLKSVEEK--LSLAQEDL-ISNRNQI---GNQN---KLIQELK 1081
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK--EIEDLEIEF 932
A +E+ D A+ E + Q + + L+ K + + + L+ +K K EIE+++
Sbjct: 1082 TAKATLEQ----DSAKKEQ-QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 933 N---TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLEL 988
T++ ++ K+ + K N++ QL Q + E + ++L VE+ K N ++
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ-EKRNQQI 1195
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ V+K++ + +++I + KL++ +K+K E+ + N A+++ ++
Sbjct: 1196 LKDQVKKEE---EELKKEFIEKEAKLHSEIKEK--EVGMKKHEENEAKLT--MQITALNE 1248
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
L + ++ + + + KQ D + L+ V+ D+ + L E L E I K
Sbjct: 1249 NLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK 1308
Query: 1109 TEGMII 1114
+ ++
Sbjct: 1309 LQTKVL 1314
Score = 89.8 bits (213), Expect = 7e-17
Identities = 148/785 (18%), Positives = 332/785 (42%), Gaps = 64/785 (8%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
+L + ++E+ L Q ++ +ET++ +L ++NE + + +
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
D + + Q A++ + + E ++ ++ ++ +E LE+
Sbjct: 657 AKTAQRADLQNHLDTAQN---ALQ-DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 266 EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELT 325
E ++ L Q+ E+ + K S E + ++ + + + TEL+
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEV-KASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
K++E+ + + + T +L+ K S+A+ S +K L ++ + +K
Sbjct: 772 KQLEMEKEI---VSSTRLDLQKK-------SEALESIKQK---LTKQEEEKQI---LKQD 815
Query: 386 WSQLSSETLNQDTDKKINKNEI-AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXG 444
+ LS ET KI E+ +++ + L K ++KE +++E T
Sbjct: 816 FETLSQET-------KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868
Query: 445 KDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK-VQEQLKQELNDEIKDVNVKDLIE 503
++ + E+Q +G + I D+ + K ++ QL+ ++ + +K+ K+L +
Sbjct: 869 LKNSKSEFEKENQ---KGKAAI------LDLEKTCKELKHQLQVQMENTLKE--QKELKK 917
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
L+ +E QL E+++ + +I+ ++ K K+ Q+ N +++ S+++ + E
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 564 LH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
L L V + E + LQ L E + K+ ++N E + L+S
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE---KISVLQNNYEKSQETFKQLQSD 1034
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQ---LQSDQVCSEIKSVHLEEQIDAL---SASKK 676
+ EL +Q VE+KL+ + +Q+ ++ K + + A ++KK
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094
Query: 677 ELALVIENLKLDKEQLYGTIKDLE--NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
E L L Q ++K+ E N+K + + ++ ++T E++ + K+
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 735 L--LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
+ + + +Q IQ + + K +E + K ++ + EE + ++
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL-----KK 1209
Query: 793 YSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
+E++A +L S ++EK+ ++ E +L ++ L ++ V+K+ + EL+
Sbjct: 1210 EFIEKEA-KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268
Query: 853 KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
K+ L E L+ ++ + Q AL+E+ + E E K QT++ +L+ L T
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLK---GEGEIEKLQTKVLELQRKLDNTTA 1325
Query: 913 EHQTL 917
Q L
Sbjct: 1326 AVQEL 1330
Score = 52.4 bits (120), Expect = 1e-05
Identities = 102/550 (18%), Positives = 220/550 (40%), Gaps = 50/550 (9%)
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL-QILVREQDDQIKELKETKLTFEMN 1105
ES LA + + +E+Q + L + K ++EEL + L + Q Q +E K L + +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 1106 --IPKTEGMIISSTIEPMS----DDANNVDXXXXXXXXXXXXLKVQEE----EEFIQERS 1155
+ E + + E + D K EE E Q+ +
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 1156 VLQEQSAKLNTELQECYTKIIQ-------------LETLNTELTGHDVVNQEQINQLKSK 1202
L E+ K T +Q+ T+++Q L + T + + + + +LK +
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLS 1262
++L ++ + +T+++LRS ++ + + EL Q L + + L L
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL--QKLKSSVNELTQKNQTLTENLL 312
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQ----VTSLQNKLQDKEEHLRNLQEKYADVIN 1318
E Y +L + + + N T+ Q LQ++L E L + + ++
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 1319 QIEILRSEIEDEKVAFXXXXX------XXXXXXXXXXXDLRTE-NQSYKQMQEQSILNIN 1371
+ L+ E+ + + + L++E NQ + ++ E +
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE-RQLG 431
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN 1431
E + +LK+ +V D + K+ L QL+ K + + H+ T Q
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491
Query: 1432 DE---FENVRQQLVEYEKRIEDLTY---EKESELAILRLKMHENANHYETMQKESEIERV 1485
++ ++ +L E + +E + +K+ ++ L + ++ + ++KE E
Sbjct: 492 EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE---- 547
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAK-TNEMQTALENQEIEIVTLNDEITNLQ 1544
L ++ E+ LN Q+ E N L+E+V + T +++ E+ + L+D++ +
Sbjct: 548 DLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
Query: 1545 NMVRASSSKI 1554
+RA+ ++
Sbjct: 607 AHLRAAQDRV 616
>BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6,
cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
protein.
Length = 1939
Score = 131 bits (316), Expect = 2e-29
Identities = 229/1140 (20%), Positives = 477/1140 (41%), Gaps = 100/1140 (8%)
Query: 471 NTEDVNEIAKVQEQ---LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ E E+A ++E+ +K+ L E + K+L EK+ S ++ L ++ A N+
Sbjct: 844 SAETEKEMATMKEEFGRIKETL--EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
+ +K I +KV + N+ + E L+ K +LE+E L+ D
Sbjct: 902 DAEERCDQLIKNK---IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK---D 955
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL--- 1012
Query: 648 SQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-------DL 699
Q++ D+V S KS V LE+Q+D L S ++ V +L+ K +L G +K DL
Sbjct: 1013 -QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL-LAKINHEEQSKI-QTQFGIDAKI 757
ENDK + KL+ ++ D+ + K+ E++ L L K E Q++I + + ++A+
Sbjct: 1072 ENDKLQLEEKLK---KKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
R +E + S+LS+ I E + + +K + + Q+ ++ E T
Sbjct: 1129 TAR-AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEAT 1184
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+Q + A+ H + E+ + LQ+ Q L +E ++ L D+ +
Sbjct: 1185 LQHE--ATAAALRKKH----ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238
Query: 878 ALVE-KANRTDLA---ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+++ KAN ++ E ++ +Y+ +L + + +L T + L + + LE E
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE-EKE 1297
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
I R K ++ E L+ QL+E + +N + + + + +L+ +
Sbjct: 1298 ALISQLTRGKLSYTQQME-------DLKRQLEE-EGKAKNALAHALQSARHDCDLL-REQ 1348
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+++T++ ++ +++ N A + K E + I +++ A+ + D E +
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 1053 FTTKLENMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
K ++E+ R+ + ++D ++ N L ++Q + K L E K +E +
Sbjct: 1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES--- 1465
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
S +E +A ++ ++ E F +E LQE+ + L +L
Sbjct: 1466 ------QSELESSQKEARSLSTELFKLKNAYEE-SLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
E + +LE + +L + Q + + ++ LE + ++++ I +
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1578
Query: 1229 DQRGFEIAELWKQHLAQREADFQKT----EHELRVQLSAFESKYEQLLDSVQSSTQEETN 1284
++ E+ + + H QR D +T E R ++ + K E L+ ++
Sbjct: 1579 AEKDEEMEQAKRNH--QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636
Query: 1285 KIV-TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
+QV SLQ+ L+D + L +L+E A V + +L++E+E+ +
Sbjct: 1637 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696
Query: 1337 XXXXXXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXX 1390
L ++N S +++ ++ + ++++++
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756
Query: 1391 XXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVE 1443
+ DA EL + + E +K E TI L R DE E + ++QL +
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Query: 1444 YEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITES 1498
E R+ +L E E+E ++ ++ E T Q E + + + +++L K+
Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
Query: 1499 V-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH 1557
V + +Q E + ++K ++Q L+ E ++ L+ R +K + H
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMH 1936
Score = 91.9 bits (218), Expect = 2e-17
Identities = 182/917 (19%), Positives = 396/917 (43%), Gaps = 81/917 (8%)
Query: 233 KDEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLEHSK-LAQELEQXXXXXXXXX 289
++ Q+ L D++ ++ +++SL ++ LE E SLE K + +LE+
Sbjct: 1002 QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1061
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L ++SI +K ++EEK + ++ + KIE + L Q+++ KE + ++
Sbjct: 1062 K----LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARI 1117
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
+ E +A + K L S S ++ + T Q K + E K
Sbjct: 1118 EELEEELEAERTARAKVEKLRSDLS--RELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
+ ++ + +K + Q +LE ++ L V
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ-KLEKEKSEFKLELDDVT 1234
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVK---------DLI---EKLKSAEEQITQLND 517
+N E + + E++ + L D+ + VK D KL++ ++ + +
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELEE 576
E +A + + K ++ +++ +++ ++ K ++ ++ + L ++ E E
Sbjct: 1295 EKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETE 1354
Query: 577 EKGNLQLHLVDYDS-----GRMIESDVYKKMIEMENL----------AETRLKAI----S 617
K LQ L +S E+D ++ E+E AE ++A+ S
Sbjct: 1355 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLA--DISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE K L E+ L + A D Q D++ +E K + E Q + S+ K
Sbjct: 1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
+ +L E KL K +++ LE K + NK N +E DLT++L + + + EL
Sbjct: 1475 EARSLSTELFKL-KNAYEESLEHLETFKRE--NK--NLQEEISDLTEQLGE-GGKNVHEL 1528
Query: 736 LAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDR 791
E K++ Q + +A ++ + I + E ++ K+ I R L E ME
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA 1588
Query: 792 RYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDH-DRV---VEKQLLEI 844
+ + +R D L + L + ++ +E + ++ +N + + + H +R+ +KQ+ +
Sbjct: 1589 KRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESESTKYQTQLRD 902
+ K+ Q + + N +L+ +++ +++ N L + R + ++E ++ +
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL 1708
Query: 903 LESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
+E++ + ++ H T ++ +KK++E + +++E A+++ + EK +K I +
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQ 1020
+L++ ++ +L E K N+E K +Q + ++ + ++ KL A +++
Sbjct: 1769 EELKKEQDTSAHL-----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
+ E+ A QK N V M E ++ + T + E ++ + R+ + L+D +
Sbjct: 1824 LEGELEA-EQKRNAESVKGM---RKSERRIKELTYQTEEDKKNLLRL-QDLVD------K 1872
Query: 1081 LQILVREQDDQIKELKE 1097
LQ+ V+ Q +E +E
Sbjct: 1873 LQLKVKAYKRQAEEAEE 1889
Score = 87.8 bits (208), Expect = 3e-16
Identities = 144/766 (18%), Positives = 326/766 (42%), Gaps = 52/766 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + +++ L + E KEL++K LL+E +LQ+ + Q + N
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D + + +++++ L+ E + KK+++ED E I+
Sbjct: 902 ---DAEERCDQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKKDID 957
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ D V+
Sbjct: 958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD--DLQVE 1015
Query: 995 KQQTQSPDYTEQYI-NEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKL 1050
+ + S ++ + +++ L L+Q+ + ++ +K+ + D E+
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
Q KL+ E ++ + + ++ D + +LQ ++E +I+EL+E +L E
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEE-ELEAERTARAKV 1134
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ S + + + ++ K + E EF + R L+E A L E
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNK-KREAEFQKMRRDLEE--ATLQHEATA 1191
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ +++ EL G + N +++ Q L+ + + E D++ S + ++ + + ++
Sbjct: 1192 AALRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA-KANLE 1248
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS----TQEETNK 1285
+ + + ++ + E + Q++ ++ Q + +++ +L ++ +Q K
Sbjct: 1249 KVSRTLEDQANEYRVKLE-EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGK 1307
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ +Q+ L+ +L+++ + L + ++LR + E+E A
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA--------KAEL 1359
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN-AKCSSLEK 1418
Query: 1406 T-HQL--ELKDSEI-YQKTHEYTITLTQRNDEFENV----RQQLVEYEKRIEDLTYEKES 1457
T H+L E++D + ++++ L ++ F+ + +Q+ E + +E E S
Sbjct: 1419 TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS 1478
Query: 1458 ---ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL-NKQVAELNKALE 1513
EL L+ E+ H ET ++E++ L EE++ +TE + K V EL K +
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENK----NLQEEIS-DLTEQLGEGGKNVHELEKVRK 1533
Query: 1514 EEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ + E+Q+ALE E + +I Q ++I++ ++
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1579
Score = 83.8 bits (198), Expect = 5e-15
Identities = 177/908 (19%), Positives = 372/908 (40%), Gaps = 71/908 (7%)
Query: 222 QENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQX 281
QE+ + +E + +++L K + + S +E+ L + ++ +++ +ELE+
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARI-EELEEE 1123
Query: 282 XXXXXXXXXXXXXLAKQSIEPSCEEKTE-IEEKGSLEIANMTELTKKIELLEHLNCQIRQ 340
L + + EE +E +EE G + E+ KK E + ++
Sbjct: 1124 LEAERTARAKVEKL-RSDLSRELEEISERLEEAGGATSVQI-EMNKKRE------AEFQK 1175
Query: 341 TNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK 400
++LE AT+ E+ A + K + + ++K + SE + D
Sbjct: 1176 MRRDLEE--ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Query: 401 KINKNEIAKLEMVIQSLNKDLVDK--EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
N +I K + ++ +++ L D+ EY + ++ T A+LQ E+ +
Sbjct: 1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT-----TQRAKLQTENGE 1288
Query: 459 ---HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT-- 513
+E + + T + E LK++L +E K N L L+SA
Sbjct: 1289 LARQLEEKEAL-ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNA--LAHALQSARHDCDLL 1345
Query: 514 --QLNDEIDA-ANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVR----LTEE 563
Q +E +A A + K+N ++ + K I ++ ++ K++ + E
Sbjct: 1346 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405
Query: 564 LHHLSQKVAELEEEKGNLQLHL----VDYDSGRMIESDVYKKMIEMEN-LAETRLK---A 615
+ ++ K + LE+ K LQ + VD + + + KK + LAE + K +
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 616 ISLLESQKFD---LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
S LES + + L EL L+ Y+E + L + ++ + EI L EQ+
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR-ENKNLQEEISD--LTEQLGEGG 1522
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKI 732
+ EL V + L+++K +L +++ E E K+ E + ++E+ AEK
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582
Query: 733 SEL-LAKINHEE-QSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICRLEESIAVME 789
E+ AK NH+ +QT + + + L + + +E +L++ + ++ A
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAA--- 1639
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE----IE 845
+++ L S L++ Q + D+L +A++ + +++ +L E +E
Sbjct: 1640 ----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+ + Q L+E ++ +Q+ S N + + +SE + + R+ E
Sbjct: 1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEE 1755
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ-LEAQL 964
K+ + + + KKE +D ++ + K L + ++ + + + QL
Sbjct: 1756 KAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQL 1814
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
Q+ + + L +E K N E + K ++K + + + T Y E +K N L Q +
Sbjct: 1815 QKLEARVRELEGELEAEQKRNAESV-KGMRKSERRIKELT--YQTEEDKKNLLRLQDLVD 1871
Query: 1025 IIALNQKINNAQVSYMSMVSDYE-SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
+ L K Q ++ SK + +L+ EE Q+ + + ++
Sbjct: 1872 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGA 1931
Query: 1084 LVREQDDQ 1091
+ D++
Sbjct: 1932 KQKMHDEE 1939
Score = 79.8 bits (188), Expect = 7e-14
Identities = 183/1114 (16%), Positives = 464/1114 (41%), Gaps = 93/1114 (8%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXXXXXX 205
+ T+++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 861 IKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----ANKLL 260
+ + +M A + + +DE L KDI+ ++ ++ +E+ NK+
Sbjct: 921 VKEM--NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978
Query: 261 EAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEI 318
L+ +KL +E ++ + + + + K ++E++ ++
Sbjct: 979 NLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD-DL 1036
Query: 319 ANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR- 376
E KK+ + LE ++ K + + + + + KK I++++ +
Sbjct: 1037 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKI 1096
Query: 377 ----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKD 432
A +++ + + + + + + AK+E + L+++L + + E
Sbjct: 1097 EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1156
Query: 433 TXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL------K 486
++ +++ + ++ + + +A++ EQ+ K
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1216
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
Q+L E + ++ ++ + S EQI + ++ ++ + + +++KL++ Q+++++
Sbjct: 1217 QKLEKEKSEFKLE--LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLND 1274
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
F+ + +L E L++++ E E L + Y + + K+ +E E
Sbjct: 1275 FT------TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ----QMEDLKRQLEEE 1324
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
A+ L L+S + D +L+++Y+E + A++ ++ S + SE+ +
Sbjct: 1325 GKAKNAL--AHALQSARHD----CDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKY 1377
Query: 667 QIDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ DA L +KK+LA +++ + E + LE K ++LQN I++ M
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK----HRLQNEIEDLMVD 1433
Query: 721 TDKLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
++ +A +K KI E + K + ++++ ++ +EL K K+
Sbjct: 1434 VERSNAAAAALDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTELFKLKNAY 1490
Query: 779 CRLEESIAVMEDRRYSLERKADQL-------GSYLQEKQKAYSEYTIQEDELVNRL---- 827
E + + +L+ + L G + E +K + +++ EL + L
Sbjct: 1491 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A L + + + LE E+++K L E+++ ++ + + Q+ ++L +
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 888 LAESESTKYQTQLR-DLESNLKRITHEHQTLIVQKKKEIEDLE-IEFNTQIESAIRDKKV 945
+ +E + + ++ DL +++H ++ + + +K+++ L+ + +TQI+ + D
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANR-MAAEAQKQVKSLQSLLKDTQIQ--LDDAVR 1664
Query: 946 LNEKYEKNIEYVTQ----LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
N+ ++NI V + L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1722
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K+ + L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1723 ---TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1778
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+++ E + + Q+N+L++K + +
Sbjct: 1899 RKVQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
>Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 129 bits (312), Expect = 7e-29
Identities = 229/1140 (20%), Positives = 476/1140 (41%), Gaps = 100/1140 (8%)
Query: 471 NTEDVNEIAKVQEQ---LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ E E+A ++E+ +K+ L E + K+L EK+ S ++ L ++ A N+
Sbjct: 844 SAETEKEMATMKEEFGRIKETL--EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
+ +K I +KV + N+ + E L+ K +LE+E L+ D
Sbjct: 902 DAEERCDQLIKNK---IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK---D 955
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL--- 1012
Query: 648 SQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-------DL 699
Q++ D+V S KS V LE+Q+D L S ++ V +L+ K +L G +K DL
Sbjct: 1013 -QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL-LAKINHEEQSKI-QTQFGIDAKI 757
ENDK + KL+ ++ D+ + K+ E+ L L K E Q++I + + ++A+
Sbjct: 1072 ENDKLQLEEKLK---KKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAER 1128
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
R +E + S+LS+ I E + + +K + + Q+ ++ E T
Sbjct: 1129 TAR-AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEAT 1184
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+Q + A+ H + E+ + LQ+ Q L +E ++ L D+ +
Sbjct: 1185 LQHE--ATAAALRKKH----ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238
Query: 878 ALVE-KANRTDLA---ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+++ KAN ++ E ++ +Y+ +L + + +L T + L + + LE E
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE-EKE 1297
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
I R K ++ E L+ QL+E + +N + + + + +L+ +
Sbjct: 1298 ALISQLTRGKLSYTQQME-------DLKRQLEE-EGKAKNALAHALQSARHDCDLL-REQ 1348
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+++T++ ++ +++ N A + K E + I +++ A+ + D E +
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 1053 FTTKLENMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
K ++E+ R+ + ++D ++ N L ++Q + K L E K +E +
Sbjct: 1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES--- 1465
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
S +E +A ++ ++ E F +E LQE+ + L +L
Sbjct: 1466 ------QSELESSQKEARSLSTELFKLKNAYEE-SLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
E + +LE + +L + Q + + ++ LE + ++++ I +
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1578
Query: 1229 DQRGFEIAELWKQHLAQREADFQKT----EHELRVQLSAFESKYEQLLDSVQSSTQEETN 1284
++ E+ + + H QR D +T E R ++ + K E L+ ++
Sbjct: 1579 AEKDEEMEQAKRNH--QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636
Query: 1285 KIV-TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
+QV SLQ+ L+D + L +L+E A V + +L++E+E+ +
Sbjct: 1637 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696
Query: 1337 XXXXXXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXX 1390
L ++N S +++ ++ + ++++++
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756
Query: 1391 XXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVE 1443
+ DA EL + + E +K E TI L R DE E + ++QL +
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Query: 1444 YEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITES 1498
E R+ +L E E+E ++ ++ E T Q E + + + +++L K+
Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
Query: 1499 V-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH 1557
V + +Q E + ++K ++Q L+ E ++ L+ R +K + H
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMH 1936
Score = 92.3 bits (219), Expect = 1e-17
Identities = 182/917 (19%), Positives = 396/917 (43%), Gaps = 81/917 (8%)
Query: 233 KDEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLEHSK-LAQELEQXXXXXXXXX 289
++ Q+ L D++ ++ +++SL ++ LE E SLE K + +LE+
Sbjct: 1002 QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1061
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L ++SI +K ++EEK + ++ + KIE + L Q+++ KE + ++
Sbjct: 1062 K----LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARI 1117
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
+ E +A + K L S S ++ + T Q K + E K
Sbjct: 1118 EELEEELEAERTARAKVEKLRSDLS--RELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
+ ++ + +K + Q +LE ++ L V
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ-KLEKEKSEFKLELDDVT 1234
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVK---------DLI---EKLKSAEEQITQLND 517
+N E + + E++ + L D+ + VK D KL++ ++ + +
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELEE 576
E +A + + K ++ +++ +++ ++ K ++ ++ + L ++ E E
Sbjct: 1295 EKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETE 1354
Query: 577 EKGNLQLHLVDYDS-----GRMIESDVYKKMIEMENL----------AETRLKAI----S 617
K LQ L +S E+D ++ E+E AE ++A+ S
Sbjct: 1355 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLA--DISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE K L E+ L + A D Q D++ +E K + E Q + S+ K
Sbjct: 1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
+ +L E KL K +++ LE K + NK N +E DLT++L + + + EL
Sbjct: 1475 EARSLSTELFKL-KNAYEESLEHLETFKRE--NK--NLQEEISDLTEQLGE-GGKNVHEL 1528
Query: 736 LAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDR 791
E K++ Q + +A ++ + I + E ++ K+ I R L E ME
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA 1588
Query: 792 RYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDH-DRV---VEKQLLEI 844
+ + +R D L + L + ++ +E + ++ +N + + + H +R+ +KQ+ +
Sbjct: 1589 KRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESESTKYQTQLRD 902
+ K+ Q + + N +L+ +++ +++ N L + R + ++E ++ +
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL 1708
Query: 903 LESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
+E++ + ++ H T ++ +KK++E + +++E A+++ + EK +K I +
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQ 1020
+L++ ++ +L E K N+E K +Q + ++ + ++ KL A +++
Sbjct: 1769 EELKKEQDTSAHL-----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
+ E+ A QK N V M E ++ + T + E ++ + R+ + L+D +
Sbjct: 1824 LEGELEA-EQKRNAESVKGM---RKSERRIKELTYQTEEDKKNLLRL-QDLVD------K 1872
Query: 1081 LQILVREQDDQIKELKE 1097
LQ+ V+ Q +E +E
Sbjct: 1873 LQLKVKAYKRQAEEAEE 1889
Score = 88.2 bits (209), Expect = 2e-16
Identities = 144/766 (18%), Positives = 326/766 (42%), Gaps = 52/766 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + +++ L + E KEL++K LL+E +LQ+ + Q + N
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D + + +++++ L+ E + KK+++ED E I+
Sbjct: 902 ---DAEERCDQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKKDID 957
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ D V+
Sbjct: 958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD--DLQVE 1015
Query: 995 KQQTQSPDYTEQYI-NEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKL 1050
+ + S ++ + +++ L L+Q+ + ++ +K+ + D E+
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
Q KL+ E ++ + + ++ D + +LQ ++E +I+EL+E +L E
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEE-ELEAERTARAKV 1134
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ S + + + ++ K + E EF + R L+E A L E
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNK-KREAEFQKMRRDLEE--ATLQHEATA 1191
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ +++ EL G + N +++ Q L+ + + E D++ S + ++ + + ++
Sbjct: 1192 AALRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA-KANLE 1248
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS----TQEETNK 1285
+ + + ++ + E + Q++ ++ Q + +++ +L ++ +Q K
Sbjct: 1249 KVSRTLEDQANEYRVKLE-EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGK 1307
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ +Q+ L+ +L+++ + L + ++LR + E+E A
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA--------KAEL 1359
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN-AKCSSLEK 1418
Query: 1406 T-HQL--ELKDSEI-YQKTHEYTITLTQRNDEFENV----RQQLVEYEKRIEDLTYEKES 1457
T H+L E++D + ++++ L ++ F+ + +Q+ E + +E E S
Sbjct: 1419 TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS 1478
Query: 1458 ---ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL-NKQVAELNKALE 1513
EL L+ E+ H ET ++E++ L EE++ +TE + K V EL K +
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENK----NLQEEIS-DLTEQLGEGGKNVHELEKVRK 1533
Query: 1514 EEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ + E+Q+ALE E + +I Q ++I++ ++
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1579
Score = 84.2 bits (199), Expect = 3e-15
Identities = 177/908 (19%), Positives = 372/908 (40%), Gaps = 71/908 (7%)
Query: 222 QENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQX 281
QE+ + +E + +++L K + + S +E+ L + ++ +++ +ELE+
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARI-EELEEE 1123
Query: 282 XXXXXXXXXXXXXLAKQSIEPSCEEKTE-IEEKGSLEIANMTELTKKIELLEHLNCQIRQ 340
L + + EE +E +EE G + E+ KK E + ++
Sbjct: 1124 LEAERTARAKVEKL-RSDLSRELEEISERLEEAGGATSVQI-EMNKKRE------AEFQK 1175
Query: 341 TNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK 400
++LE AT+ E+ A + K + + ++K + SE + D
Sbjct: 1176 MRRDLEE--ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Query: 401 KINKNEIAKLEMVIQSLNKDLVDK--EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
N +I K + ++ +++ L D+ EY + ++ T A+LQ E+ +
Sbjct: 1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT-----TQRAKLQTENGE 1288
Query: 459 ---HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT-- 513
+E + + T + E LK++L +E K N L L+SA
Sbjct: 1289 LARQLEEKEAL-ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNA--LAHALQSARHDCDLL 1345
Query: 514 --QLNDEIDA-ANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVR----LTEE 563
Q +E +A A + K+N ++ + K I ++ ++ K++ + E
Sbjct: 1346 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405
Query: 564 LHHLSQKVAELEEEKGNLQLHL----VDYDSGRMIESDVYKKMIEMEN-LAETRLK---A 615
+ ++ K + LE+ K LQ + VD + + + KK + LAE + K +
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 616 ISLLESQKFD---LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
S LES + + L EL L+ Y+E + L + ++ + EI L EQ+
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR-ENKNLQEEISD--LTEQLGEGG 1522
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKI 732
+ EL V + L+++K +L +++ E E K+ E + ++E+ AEK
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582
Query: 733 SEL-LAKINHEE-QSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICRLEESIAVME 789
E+ AK NH+ +QT + + + L + + +E +L++ + ++ A
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAA--- 1639
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE----IE 845
+++ L S L++ Q + D+L +A++ + +++ +L E +E
Sbjct: 1640 ----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+ + Q L+E ++ +Q+ S N + + +SE + + R+ E
Sbjct: 1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEE 1755
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ-LEAQL 964
K+ + + + KKE +D ++ + K L + ++ + + + QL
Sbjct: 1756 KAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQL 1814
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
Q+ + + L +E K N E + K ++K + + + T Y E +K N L Q +
Sbjct: 1815 QKLEARVRELEGELEAEQKRNAESV-KGMRKSERRIKELT--YQTEEDKKNLLRLQDLVD 1871
Query: 1025 IIALNQKINNAQVSYMSMVSDYE-SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
+ L K Q ++ SK + +L+ EE Q+ + + ++
Sbjct: 1872 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGA 1931
Query: 1084 LVREQDDQ 1091
+ D++
Sbjct: 1932 KQKMHDEE 1939
Score = 80.2 bits (189), Expect = 6e-14
Identities = 183/1114 (16%), Positives = 464/1114 (41%), Gaps = 93/1114 (8%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXXXXXX 205
+ T+++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 861 IKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----ANKLL 260
+ + +M A + + +DE L KDI+ ++ ++ +E+ NK+
Sbjct: 921 VKEM--NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978
Query: 261 EAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEI 318
L+ +KL +E ++ + + + + K ++E++ ++
Sbjct: 979 NLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD-DL 1036
Query: 319 ANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR- 376
E KK+ + LE ++ K + + + + + KK I++++ +
Sbjct: 1037 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKI 1096
Query: 377 ----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKD 432
A +++ + + + + + + AK+E + L+++L + + E
Sbjct: 1097 EDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1156
Query: 433 TXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL------K 486
++ +++ + ++ + + +A++ EQ+ K
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1216
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
Q+L E + ++ ++ + S EQI + ++ ++ + + +++KL++ Q+++++
Sbjct: 1217 QKLEKEKSEFKLE--LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLND 1274
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
F+ + +L E L++++ E E L + Y + + K+ +E E
Sbjct: 1275 FT------TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ----QMEDLKRQLEEE 1324
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
A+ L L+S + D +L+++Y+E + A++ ++ S + SE+ +
Sbjct: 1325 GKAKNAL--AHALQSARHD----CDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKY 1377
Query: 667 QIDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ DA L +KK+LA +++ + E + LE K ++LQN I++ M
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK----HRLQNEIEDLMVD 1433
Query: 721 TDKLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
++ +A +K KI E + K + ++++ ++ +EL K K+
Sbjct: 1434 VERSNAAAAALDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTELFKLKNAY 1490
Query: 779 CRLEESIAVMEDRRYSLERKADQL-------GSYLQEKQKAYSEYTIQEDELVNRL---- 827
E + + +L+ + L G + E +K + +++ EL + L
Sbjct: 1491 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A L + + + LE E+++K L E+++ ++ + + Q+ ++L +
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 888 LAESESTKYQTQLR-DLESNLKRITHEHQTLIVQKKKEIEDLE-IEFNTQIESAIRDKKV 945
+ +E + + ++ DL +++H ++ + + +K+++ L+ + +TQI+ + D
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANR-MAAEAQKQVKSLQSLLKDTQIQ--LDDAVR 1664
Query: 946 LNEKYEKNIEYVTQ----LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
N+ ++NI V + L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1722
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K+ + L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1723 ---TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1778
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+++ E + + Q+N+L++K + +
Sbjct: 1899 RKVQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
>L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated protein
protein.
Length = 1410
Score = 129 bits (311), Expect = 9e-29
Identities = 234/1202 (19%), Positives = 500/1202 (41%), Gaps = 93/1202 (7%)
Query: 388 QLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKD- 446
+ +E N K + + + A+L I + K D+E + E K+
Sbjct: 146 EAQTENFNIKQMKDLFEQKAAQLATEIADI-KSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDLIE 503
T+I L+ E Q P + V +++ ++ + + + ++ ++++KD + K
Sbjct: 205 TVIQDLKTELLQR---PGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDES-KKFES 260
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
+ S+E I+QL E+ + ++V KLK + ++ N +++ ++
Sbjct: 261 QYASSEATISQLRSELSKGPQE-VRVYVQELQKLKSSVNELTQKNQTLTEN--LLKKEQD 317
Query: 564 LHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM------IESDVYKKMIEMENLAETRLKA 615
L +K E K N+Q LH D D ++ E+ +++ +E+ E K
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 616 ---ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
+S +E++ L E LQQ+ +E E QLQS+ K + E Q+
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGL---QLQSEINQLHSKLLETERQLGEAH 434
Query: 673 ASKKELALVIENLKLDKEQLYGTIK-DLENDKEDIMNKLQNY--IQENMDLTDKLEKMSA 729
KE + +DKEQ ++ L +E + K+ N +Q +D T + +
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
AK+ E Q+ ++ + +I E+D I+N+E+ L K K I LE+ +
Sbjct: 495 ALQQSTTAKLR-EAQNDLEQ---VLRQIGEKDQKIQNLEALLQKSKENISLLEKEREDLY 550
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
+ + E + L LQEK +T+Q++ V +L + + KQ E H+
Sbjct: 551 AKIQAGEGETAVLNQ-LQEKN-----HTLQDE--VTQLTENVKNQSESHKQAQENLHDQV 602
Query: 850 ELQKKNQILLEENQ-NLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLK 908
+ QK + ++ +L+ S++++ N EK ++ D+ T+ ++ +
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 909 RITHEH----QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
H Q + K +E+ + + + Q+ + ++DK+ E+ +QLE+ L
Sbjct: 663 ADLQNHLDTAQNALQDKHQELNKITTQLD-QVTAKLQDKQ----------EHCSQLESHL 711
Query: 965 QEYKNNIENLNMNVEELN----KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA--LL 1018
+EYK +L EEL K+ + ++ K+Q ++ +N +L A L
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 1019 KQKD-EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQ 1076
KQ + E+ I + +++ + S + + KL + + + ++++ + +S++ + ++
Sbjct: 772 KQLEMEKEIVSSTRLDLQKKS--EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE 829
Query: 1077 HNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE-PMSDDANNVDXXXXXX 1135
N +Q V E ++K KE +T E++ K + +S +++ S+
Sbjct: 830 LNNRIQTTVTELQ-KVKMEKEALMT-ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSA---KLNTELQECYTKIIQLETLNTELTGHDVV- 1191
K + + +Q + L+EQ L E + + ++L ++ +L
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 1192 --NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
N+++ QL+ + +L ++ + L+ + AV Q+ E+ +Q L Q +
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT-ELENKLQQQLTQAAQE 1006
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
+ ++ V + +E E E+ + T + + S++ KL +E L +
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
Query: 1310 QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN 1369
+ + NQ ++++ E++ K L+ + Q K ++E+ ++N
Sbjct: 1067 RNQIG---NQNKLIQ-ELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKEKSLKEKELVN 1121
Query: 1370 INEENAQLKKSSXXXXXXXXXXXXRVNDAEAK-VLELTHQLELKDSEIYQKTH-EYTITL 1427
+ A++++ + + + + E+T+ + K I QK +
Sbjct: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADS 1181
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
+ E E QQ+++ + + E+ E + E K+H E K+ E K
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEE--EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK- 1238
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L ++IT +LN+ + + K + + +E++ ++ EI L + N Q+
Sbjct: 1239 ---LTMQIT---ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDER 1292
Query: 1548 RA 1549
RA
Sbjct: 1293 RA 1294
Score = 124 bits (299), Expect = 3e-27
Identities = 244/1163 (20%), Positives = 500/1163 (42%), Gaps = 130/1163 (11%)
Query: 477 EIAKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
E+ K E+ + E K D V D +L+S E+Q+ +E N N+ ++K +
Sbjct: 108 ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL----EEAQTENFNIKQMKDLFEQ 163
Query: 536 KLKQMQKTIDNFSKVSDSNK--------EIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
K Q+ I + D + ++ RLTEEL+ + + +L+ E L
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL----LQRPG 219
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
+ +++ ++ + M+N+ R + ES+K L E + +Y E A I
Sbjct: 220 IEDVAVLKKELVQVQTLMDNMTLERER-----ESEK--LKDESKKFESQYASSE---ATI 269
Query: 648 SQLQSD--QVCSEIKSVHLEEQIDALSASKKELA----LVIENLKLDKEQLYGTIKDLEN 701
SQL+S+ + E++ V+++E + L +S EL + ENL L KEQ Y +++ N
Sbjct: 270 SQLRSELSKGPQEVR-VYVQE-LQKLKSSVNELTQKNQTLTENL-LKKEQDYTKLEEKHN 326
Query: 702 DKEDIMNKLQNYI-QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
++ +Q + Q+++D ++SA + S L +I+ E K + K++E
Sbjct: 327 EESVSKKNIQATLHQKDLDCQQLQSRLSASETS--LHRIHVELSEKGEAT----QKLKEE 380
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY--TI 818
+ +E++ K+ +L++ E L+ + +QL S L E ++ E +
Sbjct: 381 ---LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+E ++ LMD ++ V L++ ++L++K + + LQ L +Q +
Sbjct: 438 KEQRQLSS-EKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQHQLDKTKQQHQ- 491
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL-----IVQKKKE----IEDLE 929
+ L +S + K + DLE L++I + Q + ++QK KE +E
Sbjct: 492 -----EQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQNLEALLQKSKENISLLEKER 546
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNI---EYVTQL----EAQLQEYKNNIENLNMNVEELN 982
+ +I++ + VLN+ EKN + VTQL + Q + +K ENL+ V+E
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLTENVKNQSESHKQAQENLHDQVQE-Q 605
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
K +L V +T + Q +N+ + Q D +I A + + +A+ + +
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQ----LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+D ++ L L++ +E+ +++ QL ++ Q + + +KE KE L+
Sbjct: 662 RADLQNHLDTAQNALQDKHQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 1103 EMNIPKTEGMI---------ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ---EEEEF 1150
E + EG I + ++ E D L Q E+E
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 1151 IQERSVLQEQSAKLNT-----ELQECYTKIIQ--LETLNTEL-TGHDVVNQEQINQLKSK 1202
R LQ++S L + QE +I++ ETL+ E H+ +N +I ++
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN-NRIQTTVTE 840
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA--DFQKT----EHE 1256
L+++ E + L++ ++ ++ +S D +E K++ + A D +KT +H+
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
Query: 1257 LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
L+VQ+ + ++L S++ ++E + + +E + S+Q +L + L+ +++ +
Sbjct: 901 LQVQMENTLKEQKELKKSLEK--EKEASHQLKLE-LNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
I L+ E +K +L + Q Q + E+ +
Sbjct: 958 QGNINELKQSSEQKKKQI-EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1016
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
L+ + E+++L L K+ E ++L Q D N
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDL---------KSVEEKLSLAQ-EDLISN 1066
Query: 1437 VRQQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
R Q+ K I++L K E + A ++ E + +QKE ++ +L+ E +
Sbjct: 1067 -RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS- 1124
Query: 1494 KITESVSL----NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
K+ E + K++ +LN+ L+ ++ + T L++ + ++ E+ + ++A
Sbjct: 1125 KLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKA 1184
Query: 1550 SSSKIQKHVSFASDTKQGRDEQL 1572
+ + +++ D + +E+L
Sbjct: 1185 AVEQEKRNQQILKDQVKKEEEEL 1207
Score = 123 bits (296), Expect = 6e-27
Identities = 225/1140 (19%), Positives = 464/1140 (40%), Gaps = 100/1140 (8%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRI--SSLEEANKLLEAARFEISL 269
E +Q++T++ E +D K LL+ +DV + L + L++ E
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
E KL E ++ L + + E + ++E L+ +++ ELT+K +
Sbjct: 247 ESEKLKDESKKFESQYASSEATISQLRSELSKGPQEVRVYVQELQKLK-SSVNELTQKNQ 305
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
L + Q +LE K K + + + + R +AS+ +
Sbjct: 306 TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+ T K K E++++E Q L + + EK+
Sbjct: 366 ELSEKGEATQKL--KEELSEVETKYQHLKAEFKQLQQQREEKEQHG-------------- 409
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE-LNDEIKDVNVKDLIEKLKSA 508
LQL+ + + L+ + + K Q QL E L D K+ V DL KL
Sbjct: 410 --LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD--KEQQVADLQLKLSRL 465
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS 568
EEQ+ + + K K H+ + Q T +K+ ++ ++ ++ ++
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT---AKLREAQNDLEQVLRQIGEKD 522
Query: 569 QKVAELEE--EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
QK+ LE +K + L++ + D+Y K+ E ++ L+ + L
Sbjct: 523 QKIQNLEALLQKSKENISLLEKE-----REDLYAKI----QAGEGETAVLNQLQEKNHTL 573
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
E+ L + + + DQV + + HL D + + + + + L
Sbjct: 574 QDEVTQLTENVKNQSESHKQAQENLHDQV--QEQKAHLRAAQDRVLSLETSVNELNSQLN 631
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
KE++ ++ E +++ + DL + L+ ++ + H+E +K
Sbjct: 632 ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT------AQNALQDKHQELNK 685
Query: 747 IQTQFG-IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR-----RYSLERKA- 799
I TQ + AK+Q++ + +ES L +YK + LE+ +E + SLE KA
Sbjct: 686 ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745
Query: 800 -DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+Q LQ++++ ++ ++ EL +L + +V L+++ +++ L+ Q L
Sbjct: 746 KEQALQDLQQQRQLNTDLELRATELSKQLEM---EKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 859 LEENQNLQISLSDMQ---QHYNALVEKAN-RTDLAESESTKYQTQLRDLESNLKRITHEH 914
++ + QI D + Q E+ N R +E K + + L + L + +
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ K + E E N + ++AI D + ++ + ++ Q+E L+E K ++L
Sbjct: 863 SKVSDSLKNSKSEFEKE-NQKGKAAILDLEKTCKELKHQLQ--VQMENTLKEQKELKKSL 919
Query: 975 NMNVEELNKMNLELI---DKHVQKQQT--QSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
E +++ LEL ++ +Q Q T Q+ +Q IN+L +QK ++I AL
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
++ A + + + + +L Q +L +E++ + S++ ++LQ ++
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
++ ++ + E + + +IS+ N + +E
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNR--------NQIGNQNKLI------------QE 1079
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
++ L++ SAK +LQE + L+ + E + + +E +N+ KSKL ++
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQE---RCKALQDIQKEKS---LKEKELVNE-KSKLAEIEEI 1132
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELW--KQHLAQREADFQKTEHELRVQLSAFESK 1267
+ +L + S + EI L KQ L Q++ + Q L+ + E +
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ-EKR 1191
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
+Q+L Q +EE K +E+ L +++++KE ++ +E A + QI L +
Sbjct: 1192 NQQILKD-QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250
Score = 105 bits (252), Expect = 1e-21
Identities = 202/1026 (19%), Positives = 439/1026 (42%), Gaps = 102/1026 (9%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
++ T+ +KD LQ ++ ET++ + +++EK EA K
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG---EATQK-LKEELSEVETKYQ 389
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----ANKLL 260
+ +QQ + +++ + +++E +LL+ L+E + KL+
Sbjct: 390 HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 261 EAAR--FEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEI----EEKG 314
+ + ++ L+ S+L ++L++ +Q E +++ E +
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
Query: 315 SLE--IANMTELTKKIELLEHL------NCQIRQTNKE-LENKLATMGTESKAVSSPSKK 365
LE + + E +KI+ LE L N + + +E L K+ E+ ++ +K
Sbjct: 510 DLEQVLRQIGEKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
Query: 366 GSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKD 420
L ++ +N + K L + Q + ++ + LE + LN
Sbjct: 570 NHTLQDEVTQLTENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 421 LVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK 480
L + + +S+ D + + + Q H++ + + +++N+I
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD-TAQNALQDKHQELNKITT 688
Query: 481 VQEQLKQELNDEIK-----DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
+Q+ +L D+ + + ++K+ EK S E++ +L +I + ++VK++ +
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 536 KLKQMQK----------TIDNFSKVSDSNKEIVRLT--------EELHHLSQKVAELEEE 577
L+ +Q+ SK + KEIV T E L + QK+ + EEE
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
K Q+ D+++ + + + E+ N +T + + ++ +K L+ EL ++ K
Sbjct: 809 K---QILKQDFET---LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 638 DEVEDKLADI-SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
+V D L + S+ + + + + LE+ L K +L + +EN ++++L
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQMENTLKEQKELK--- 916
Query: 697 KDLENDKE-DIMNKLQ-NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
K LE +KE KL+ N +QE + K + ++ +L IN +QS Q + I+
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS 814
A E + + +K + ++ + + +A +++ L+ ++ ++ Q S
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ---S 1033
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
++ +E EL LA D V EK L + E+ + +NQI NQN L +
Sbjct: 1034 DFYGRESEL---LATRQDLKSVEEK--LSLAQEDL-ISNRNQI---GNQN---KLIQELK 1081
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK--EIEDLEIEF 932
A +E+ D A+ E + Q + + L+ K + + + L+ +K K EIE+++
Sbjct: 1082 TAKATLEQ----DSAKKEQ-QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 933 N---TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLEL 988
T++ ++ K+ + K N++ QL Q + E + ++L VE+ K N ++
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ-EKRNQQI 1195
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ V+K++ + +++I + KL++ +K+K E+ + N A+++ ++
Sbjct: 1196 LKDQVKKEE---EELKKEFIEKEAKLHSEIKEK--EVGMKKHEENEAKLT--MQITALNE 1248
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
L + ++ + + + KQ D + L+ V+ D+ + L E L E I K
Sbjct: 1249 NLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK 1308
Query: 1109 TEGMII 1114
+ ++
Sbjct: 1309 LQTKVL 1314
Score = 105 bits (252), Expect = 1e-21
Identities = 199/900 (22%), Positives = 375/900 (41%), Gaps = 72/900 (8%)
Query: 162 QVKMKIMETTILDLQ-EKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQ--- 217
Q+K K+ +T L Q +K ++ Q +A ++TT + Q+
Sbjct: 468 QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQN 527
Query: 218 ----MTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS----- 268
+ K +EN +E E +D ++ E + ++ L+E N L+ +++
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAG-EGETAVLNQLQEKNHTLQDEVTQLTENVKN 586
Query: 269 -LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT-ELTK 326
E K AQE S+E S E + +++ + ++
Sbjct: 587 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
K ELL +L+N L T + K + + + + + +
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKHQELNKITTQLDQVTAK--LQDKQEHC 704
Query: 387 SQLSSETLNQDTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
SQL S L + +K ++ + + +LE I+ L D + E S++
Sbjct: 705 SQLESH-LKEYKEKYLSLEQKTEELEGQIKKLEADSL--EVKASKEQALQDLQQQRQLNT 761
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELN--DEIKDVNVKDLIE 503
D + +L Q ME V + D+ + ++ E +KQ+L +E K + +D
Sbjct: 762 DLELRATELSKQLEMEKEI---VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
+ + Q +LN+ I + KVK + + ++ D SKVSDS K E+
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 564 LHHLSQK-VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
+ + + +LE+ L+ L + E KK +E E A +LK L S
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE--LNSM 936
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQ--SDQVCSEIKSVHLEEQIDALSASKKELAL 680
+ L+Q + L+Q E + +I++L+ S+Q +I+++ E +I L K EL
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ--KTEL-- 992
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
EN KL ++QL ++L +KE I + LQN +++ + +L+ + SELLA
Sbjct: 993 --EN-KL-QQQLTQAAQELAAEKEKI-SVLQNNYEKSQETFKQLQSDFYGRESELLA--T 1045
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
++ ++ + + + DL I N +++ I L+ + A +E E++
Sbjct: 1046 RQDLKSVEEKLSL----AQEDL-ISN-RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+ LQ+ QK E +++E ELVN + L + + + +Q EI N+EL+ ++
Sbjct: 1100 ERCKALQDIQK---EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
E NL+ + + Q L KA+ A + + Q L+D ++ E + L
Sbjct: 1157 EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD------QVKKEEEEL--- 1207
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN----IEYVTQLEAQLQEYKNNIENLNM 976
KKE IE ++ S I++K+V +K+E+N +T L L K ++
Sbjct: 1208 -KKEF----IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262
Query: 977 NVEELNKMNLELIDKHVQKQQT--QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
V EL K +L + + T + D + K +++ +++ L +K++N
Sbjct: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
Score = 88.2 bits (209), Expect = 2e-16
Identities = 146/779 (18%), Positives = 329/779 (42%), Gaps = 64/779 (8%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
+L + ++E+ L Q ++ +ET++ +L ++NE + + +
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
D + + Q A++ + E ++ ++ ++ +E LE+
Sbjct: 657 AKTAQRADLQNHLDTAQN---ALQ-DKHQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 266 EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELT 325
E ++ L Q+ E+ + K S E + ++ + + + TEL+
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEV-KASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
K++E+ + + + T +L+ K S+A+ S +K L ++ + +K
Sbjct: 772 KQLEMEKEI---VSSTRLDLQKK-------SEALESIKQK---LTKQEEEKQI---LKQD 815
Query: 386 WSQLSSETLNQDTDKKINKNEI-AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXG 444
+ LS ET KI E+ +++ + L K ++KE +++E T
Sbjct: 816 FETLSQET-------KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868
Query: 445 KDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK-VQEQLKQELNDEIKDVNVKDLIE 503
++ + E+Q +G + I D+ + K ++ QL+ ++ + +K+ K+L +
Sbjct: 869 LKNSKSEFEKENQ---KGKAAI------LDLEKTCKELKHQLQVQMENTLKE--QKELKK 917
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
L+ +E QL E+++ + +I+ ++ K K+ Q+ N +++ S+++ + E
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 564 LH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
L L V + E + LQ L E + K+ ++N E + L+S
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE---KISVLQNNYEKSQETFKQLQSD 1034
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQ---LQSDQVCSEIKSVHLEEQIDAL---SASKK 676
+ EL +Q VE+KL+ + +Q+ ++ K + + A ++KK
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094
Query: 677 ELALVIENLKLDKEQLYGTIKDLE--NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
E L L Q ++K+ E N+K + + ++ ++T E++ + K+
Sbjct: 1095 EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 735 L--LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
+ + + +Q IQ + + K +E + K ++ + EE + ++
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL-----KK 1209
Query: 793 YSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
+E++A +L S ++EK+ ++ E +L ++ L ++ V+K+ + EL+
Sbjct: 1210 EFIEKEA-KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268
Query: 853 KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRIT 911
K+ L E L+ ++ + Q AL+E+ + E E K QT++ +L+ L T
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLK---GEGEIEKLQTKVLELQRKLDNTT 1324
Score = 59.3 bits (137), Expect = 1e-07
Identities = 103/529 (19%), Positives = 214/529 (40%), Gaps = 39/529 (7%)
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL-QILVREQDDQIKELKETKLTFEMN 1105
ES LA + + +E+Q + L + K ++EEL + L + Q Q +E K L + +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 1106 IPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ---EEEEFIQERSVLQEQSA 1162
E + +E + N+ L + + ++ +ERS+ +
Sbjct: 135 ---AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
K+ +E + ++ L TEL + E + LK +L Q+ T DN+ T+ R
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGI--EDVAVLKKELVQVQTLMDNM--TLERERE 247
Query: 1223 SISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
S + + FE + ++Q ++ K E+RV + + K + ++ + Q
Sbjct: 248 SEKLKDESKKFESQYASSEATISQLRSELSKGPQEVRVYVQELQ-KLKSSVNELTQKNQT 306
Query: 1282 ETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF------ 1334
T ++ EQ T L+ K ++ +N+Q + L+S + + +
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQ----SYKQMQEQSILNINEENAQLKKSSXXXXXXXXX 1390
++ T+ Q +KQ+Q+Q + QL+
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR-EEKEQHGLQLQSEINQLHSKLLE 425
Query: 1391 XXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIED 1450
++ +A ++ E K + Q+ + + L++ ++ + E + +++
Sbjct: 426 TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 485
Query: 1451 LTYEKESELAILR---LKMHENANHYETMQKE--SEIERVKLIEELNVKITESVSLNKQV 1505
+ + + A+ + K+ E N E + ++ + ++++ +E L K E++SL
Sbjct: 486 TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQNLEALLQKSKENISL---- 541
Query: 1506 AELNKALEEEVAK--TNEMQTALENQ-EIEIVTLNDEITNLQNMVRASS 1551
L K E+ AK E +TA+ NQ + + TL DE+T L V+ S
Sbjct: 542 --LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLTENVKNQS 588
>BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein
protein.
Length = 1694
Score = 128 bits (310), Expect = 1e-28
Identities = 244/1173 (20%), Positives = 516/1173 (43%), Gaps = 101/1173 (8%)
Query: 464 SLIHVGTNTEDVNEIAKVQEQLKQE-LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
S I+ T V +I KV+ K E L D+IKD+N K + ++ + + + ++++
Sbjct: 29 SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKK--LSSAENDRDILRREQEQLNVE 86
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLT---EELHHLSQKVAELEEEKG 579
+ +++ N KL+ ++Q + S + I+ + EE+ L Q +++ E E
Sbjct: 87 KRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENE-- 144
Query: 580 NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
++L ++ + ++ + K E E + T + IS L+S+ DL L +Q+ ++
Sbjct: 145 IMRLSSLNQEE---LQMSLLKLNNEYEVIKSTATRDIS-LDSELHDLRLNLEAKEQELNQ 200
Query: 640 -VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
+ +K I++++ ++ + H+ D LS + E +I LK D +
Sbjct: 201 SISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 260
Query: 699 LENDKEDIMNKL----QNYIQENMDLTD-KLEKMSAE-KISELLAKINHEEQSKIQTQFG 752
LE+DK DI +L + IQ + L D L K E K+ L+ ++N ++S + Q
Sbjct: 261 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQ-K 319
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRL--EESIAVMEDRRYSLERKADQLGSYLQEKQ 810
+ +++E +I E ELS+ ++ + + ++S + +D ER+A+ ++ +
Sbjct: 320 ENLELKE---HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK-EREAE-----VRNLK 370
Query: 811 KAYSEYTIQEDELVNRLA--VLMDHDRVVEKQLLEIEHENKE-LQKKNQILLEEN---QN 864
+ SE Q +E + ++A V M+++++V ++ H+ +E L NQ+ LE+N +
Sbjct: 371 QNLSELE-QLNENLKKVAFDVKMENEKLV-LACEDVRHQLEECLAGNNQLSLEKNTIVET 428
Query: 865 LQISLSDMQQHY----NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L++ +++ L+E+AN+ + ++ + + R+L ++ ++ HEH + Q
Sbjct: 429 LKMEKGEIEAELCWAKKRLLEEANKYE----KTIEELSNARNLNTSALQLEHEHLIKLNQ 484
Query: 921 KKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN-- 977
KK D+EI E IE D K + ++E QL + + + IE L
Sbjct: 485 KK----DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSS 540
Query: 978 --VEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
EEL+K + L + +Q + D + + E N N L ++ + ++ A
Sbjct: 541 KLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN--NHLQEELERLREEQSRTAPVA 598
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ V++ S+++Q T E++EEE++ K + D Q+ ++Q+L + +Q KE+
Sbjct: 599 DPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIED--QNQSKMQLL-QSLQEQKKEM 655
Query: 1096 KETKLTFE-MNIPKTEGMI--------ISSTIEPMSDDANNV-DXXXXXXXXXXXXLKVQ 1145
E + E MN T+ + + TIE + + KVQ
Sbjct: 656 DEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQ 715
Query: 1146 --EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQEQINQLKSK 1202
E ++ + + ++ +L ++E +I L N LT D ++++++ +L
Sbjct: 716 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 775
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL------AQREADFQKTE-H 1255
++Q + E L + ++ + Q+ + + ++ + RE KTE H
Sbjct: 776 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 835
Query: 1256 ELRVQLSAFESKYEQLLDSVQ--SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKY 1313
++ ++A E+ +L D + S+ E + + + E + +L +++K+ + L +K
Sbjct: 836 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 895
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
++ ++ S +E + + +KQ ++ N+ E
Sbjct: 896 QTLLAVLQ--TSSTGNEAGGVNSNQFEELLQERDTLKQQVKKMEEWKQQVMTTVQNMQHE 953
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN-D 1432
+AQL++ + + L E ++++ K + Q +
Sbjct: 954 SAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKL--KNFGQELAQVQHSIG 1011
Query: 1433 EFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE--NANHYETMQKESEIERVKLIEE 1490
+ N + L+ D+ + S ++L + E A+ E + + SE+ + +L EE
Sbjct: 1012 QLCNTKDLLLGK----LDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL-EE 1066
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ-EIEIVTLNDEITNLQNMVRA 1549
L + E + + + E N L + +A T+E++ Q + EI L ++ LQ +++
Sbjct: 1067 LRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKE 1126
Query: 1550 SSSKIQKHVSFASDTKQGRDEQLDNTMNK-ELL 1581
I+ SD +E N +N+ ELL
Sbjct: 1127 KDLLIKA----KSDQLLSSNENFTNKVNENELL 1155
Score = 124 bits (298), Expect = 4e-27
Identities = 259/1285 (20%), Positives = 513/1285 (39%), Gaps = 105/1285 (8%)
Query: 328 IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS 387
+E E+L + + + TM TE + + + S + + + A S
Sbjct: 91 MEECENLKLECSKLQPSAVKQSDTM-TEKERILAQSASVEEVFRLQQALSDAENEIMRLS 149
Query: 388 QLSSETLNQDTDKKINKNEIAKLEMVIQ-SLNKDLVDKEYVISEKDTXXXXXXXXXXGKD 446
L+ E L K N+ E+ K SL+ +L D + K+ K+
Sbjct: 150 SLNQEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE---KE 206
Query: 447 TLIAQLQLEHQQHMEGPS--LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV-----K 499
TLIA+++ +Q+ E ++ ++ NE + +LKQ+LNDE K V+
Sbjct: 207 TLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM 266
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
D+ ++L +E++ Q E+ + ++ K K K+ + +D +K +SN I +
Sbjct: 267 DITKELDVQKEKLIQ--SEVALNDLHLTKQKLEDKV-----ENLVDQLNKSQESNVSIQK 319
Query: 560 LTEEL-HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
EL H+ Q EL + L L + ++ + ++ E+ NL + + L
Sbjct: 320 ENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQL 379
Query: 619 LESQK---FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
E+ K FD+ E L ++V +L + L + S K+ +E +
Sbjct: 380 NENLKKVAFDVKMENEKLVLACEDVRHQLEEC--LAGNNQLSLEKNTIVETLKMEKGEIE 437
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
EL + L + + TI++L N + + LQ + + L K + AE +
Sbjct: 438 AELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNI 497
Query: 736 -LAKINHEE-----QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+H+E S ++ Q + I +++++IE ++ SK + + + +++ E
Sbjct: 498 EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE 557
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH---DRVVE-----KQL 841
R ++E K LGS +E E +E +R A + D D V E QL
Sbjct: 558 ILRQTIEEKDRSLGSMKEENNHLQEELERLREE-QSRTAPVADPKTLDSVTELASEVSQL 616
Query: 842 LEI-EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
I EH +E++ +I+ ++NQ+ L +Q+ + E R + +T Q L
Sbjct: 617 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE--FRYQHEQMNATHTQLFL 674
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ + +K + Q I Q K ++ + + T ++ KV + E E
Sbjct: 675 -EKDEEIKSL----QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS 729
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
+A+ + I+ + ++ LN+ N+ L T+ D + +E+ KL +++Q
Sbjct: 730 KAETERLVKGIKERELEIKLLNEKNISL---------TKQIDQLSK--DEVGKLTQIIQQ 778
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
KD EI AL+ +I++ S+ V + +L + + E + + +++ K +
Sbjct: 779 KDLEIQALHARISS--TSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 836
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS----DDANNVDXXXXXXX 1136
+ +V ++ + +L++ + + TI+ +S + +D
Sbjct: 837 MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQ 896
Query: 1137 XXXXXLKV------------QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTE 1184
L+ + EE +QER L++Q K+ Q+ T + ++ + +
Sbjct: 897 TLLAVLQTSSTGNEAGGVNSNQFEELLQERDTLKQQVKKMEEWKQQVMTTVQNMQHESAQ 956
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
L QE+++QL++ Q+ ++DN + I S +Q ++ + Q LA
Sbjct: 957 L-------QEELHQLQA---QVLVDSDNNSKLQVDYTGLIQS-YEQNETKLKN-FGQELA 1004
Query: 1245 QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKL--QDK 1302
Q + + + + L + QL + + Q + +V S ++L Q+
Sbjct: 1005 QVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL 1064
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
EE ++LQEK A I ++ + D A L+ + +++
Sbjct: 1065 EELRKSLQEKDA-TIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1123
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
++ L I ++ QL SS + A + E LE+ ++ K
Sbjct: 1124 LKEKDLLIKAKSDQL-LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKL--KGEN 1180
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
I T R E E Q L E + + EKE E M E A +E + KE E
Sbjct: 1181 EKIVETYRGKETE--YQALQETNMKFSMMLREKEFECH----SMKEKALAFEQLLKEKEQ 1234
Query: 1483 ----ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLND 1538
E +L+ + ++V ++ ++ AL+++ + +Q ++ + N
Sbjct: 1235 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNVVQRLRDKEFRSNQ 1294
Query: 1539 EITNLQNMVRASSSKIQKHVSFASD 1563
E+ L+N + S + A D
Sbjct: 1295 ELERLRNHLLESEDSYTREALAAED 1319
Score = 101 bits (243), Expect = 2e-20
Identities = 218/1143 (19%), Positives = 467/1143 (40%), Gaps = 95/1143 (8%)
Query: 236 KQRLLKDIESK----DVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXX 291
K LLK+ E++ +S LE+ N+ L+ F++ +E+ KL E
Sbjct: 355 KDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 414
Query: 292 XXXLAKQS---IEPSCEEKTEIE------EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
L+ + +E EK EIE +K LE AN E T + EL N
Sbjct: 415 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE-ELSNARNLNTSALQ 473
Query: 343 KELENKLATMGTESKAVSSPSKKGSPL-ISRKSGRNTASKMKSPWSQLSSETLNQDTDKK 401
E E+ + + ++ K + K ++ S QL+ ++ +
Sbjct: 474 LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIE 533
Query: 402 INKNEIAKLEMVIQSLNKDLVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
K +KL+ + ++ L E + I EKD + +L+ E +
Sbjct: 534 KLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSR 593
Query: 459 H---MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDE---IKDVNVK--DLIEKLKSAEE 510
+ +L V +V+++ ++E L++E+ I+D N L++ L+ ++
Sbjct: 594 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK 653
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
++ + + + N ++ ++K +QKTI+ ++ ++ K
Sbjct: 654 EMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETK 713
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
V L E G+ + L ++ R+++ + ++ +E++ L E + ++ D V +L
Sbjct: 714 VQSLNIENGSEKHDLSKAETERLVKG-IKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 772
Query: 631 -HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
I+QQK E++ A IS Q V+L++Q+ A + ++++ V+ +
Sbjct: 773 TQIIQQKDLEIQALHARISSTSHTQ-----DVVYLQQQLQAYAMEREKVFAVLNEKTREN 827
Query: 690 EQL---YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
L Y + D+ KE + KLQ+ EN L+ + E + E + ++ + K
Sbjct: 828 SHLKTEYHKMMDIVAAKEAALIKLQD---ENKKLSTRFESSGQDMFRETIQNLSRIIREK 884
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
IDA Q+ + +++ + ++ + ++++R +L+++ ++ +
Sbjct: 885 ---DIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERD-TLKQQVKKMEEWK 940
Query: 807 QE-----KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQL----LEIEHENKELQKKNQI 857
Q+ + + +QE+ + VL+D D + Q+ L +E E + KN
Sbjct: 941 QQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKN-- 998
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQT 916
+E +Q S+ + + L+ K + S ++ Q + L ++ + E
Sbjct: 999 FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSE 1058
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN-IENLN 975
L+ Q E+E+L + ++ IR + N + +I ++LE + E ++ I+ L
Sbjct: 1059 LLQQ---ELEELRKSLQEK-DATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1114
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK----DEEIIALNQK 1031
+ L K+ L+ D ++ + Q E + N++N+ N LL+Q E I+ L
Sbjct: 1115 EKQDVLQKL-LKEKDLLIKAKSDQLLSSNENFTNKVNE-NELLRQAVTNLKERILILEMD 1172
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLE-NMEEEMQRVSKQL--LDSKQHNEELQILVREQ 1088
I + +V Y K ++ E NM+ M K+ K+ + L++E+
Sbjct: 1173 IGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK 1232
Query: 1089 D-----------DQIKELKETKLTFEMN-----IPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ + +K ++E + F+ + + + ++ ++ + + +
Sbjct: 1233 EQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNVVQRLRDKEFRS 1292
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
++ E+ + +E +++ AKL ++ +++ + +++ + +
Sbjct: 1293 NQELERLRNHLLESEDSYTREALAAEDREAKLRKKV-----TVLEEKLVSSSNAMENASH 1347
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQREADF 1250
Q + Q++S EQLN + T +L S V Q +A L +H Q E
Sbjct: 1348 QASV-QVESLQEQLNVVSKQRDETALQLSVS-QEQVKQYALSLANLQMVLEHFQQEEKAM 1405
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNL 1309
E E + QL A K + L+ S QE ++ ++ + L +L KEE + L
Sbjct: 1406 YSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEEL 1465
Query: 1310 QEK 1312
+ +
Sbjct: 1466 KRQ 1468
Score = 94.3 bits (224), Expect = 3e-18
Identities = 163/825 (19%), Positives = 346/825 (41%), Gaps = 85/825 (10%)
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
ELS Y+ RI LE + + +E S + E QK I++ E ++
Sbjct: 1 ELSDYEERIEELENLL--QQGGSGVIETDL----SKIYEMQKTIQVLQIEKVESTKKMEQ 54
Query: 830 LMDHDRVVEKQLLEIEH-------ENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
L D + + K+L E+ E ++L + + ++EE +NL++ S +Q +A+ +
Sbjct: 55 LEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQP--SAVKQS 112
Query: 883 ANRTD----LAESEST----KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
T+ LA+S S + Q L D E+ + R++ +Q + + + L E+
Sbjct: 113 DTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQE---ELQMSLLKLNNEYEV 169
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI---ENLNMNVEELNKMNLE---- 987
+A RD + +E ++ + LEA+ QE +I E L +EEL++ N E
Sbjct: 170 IKSTATRDISLDSELHDLRLN----LEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 225
Query: 988 --LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM--- 1042
LI + KQQ + + ++N + Q +++ + + ++++ + +
Sbjct: 226 MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVA 285
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
++D + K+EN+ +++ + + + ++ N EL+ +R+ ++++ ++ +L
Sbjct: 286 LNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN-ELMQ 344
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA 1162
+N + E ++ N KV + + E+ VL +
Sbjct: 345 SLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV 404
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE-QLNTENDNLLSTVAELR 1221
+ +L+EC QL L + +V E + K ++E +L LL +
Sbjct: 405 R--HQLEECLAGNNQLS-----LEKNTIV--ETLKMEKGEIEAELCWAKKRLLEEANKYE 455
Query: 1222 SSISSAVDQRGFEIA--ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSST 1279
+I + R + +L +HL + EL+ + ++ +++ D + SS
Sbjct: 456 KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL 515
Query: 1280 QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXX 1339
+E+ + + KL+++ L+ +KY+ + + EILR IE EK
Sbjct: 516 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE-EKDRSLGSMK 574
Query: 1340 XXXXXXXXXXXDLRTENQSYKQMQE----QSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
LR E + + S+ + E +QL +
Sbjct: 575 EENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKII 634
Query: 1396 NDAEAKVLELTHQL--ELKDSEIYQKTHE-----YTITLTQRNDE-------FENVRQQL 1441
D ++L L + K+ + ++ HE +T ++++E E ++ QL
Sbjct: 635 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 694
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIE--ELNVKI--TE 1497
E + I+ + E + L + + ++ + E+E VK I+ EL +K+ +
Sbjct: 695 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETE-RLVKGIKERELEIKLLNEK 753
Query: 1498 SVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
++SL KQ+ +L+K +EV K ++ ++ +++EI L+ I++
Sbjct: 754 NISLTKQIDQLSK---DEVGKLTQI---IQQKDLEIQALHARISS 792
Score = 91.9 bits (218), Expect = 2e-17
Identities = 219/1094 (20%), Positives = 452/1094 (41%), Gaps = 94/1094 (8%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
++T + KM++ I E W K+RLL++ + I L A L +A ++ EH
Sbjct: 422 KNTIVETLKMEKGEIEAELCWA--KKRLLEEANKYEKTIEELSNARNLNTSA-LQLEHEH 478
Query: 272 S-KLAQELEQXXXXXXXXXXXXXXLAKQS---IEPSCEEK---TEIEEKGSLEIANMTEL 324
KL Q+ + K++ + S EE+ T++ K + I + E
Sbjct: 479 LIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKER 538
Query: 325 TKKI--ELLEHL-----NCQIRQTNKELENKLATMGTES-------KAVSSPSKKGSPLI 370
+ K+ EL ++ N +RQT +E + L +M E+ + + + +P+
Sbjct: 539 SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVA 598
Query: 371 SRKSGRNTASKMKSPWSQLSS--ETLNQDTD--KKINKNEIAKLEMVIQSLNKDLVDKEY 426
K+ ++ +++ S SQL++ E L ++ +KI +++ ++QSL + + +
Sbjct: 599 DPKT-LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 657
Query: 427 VISEKDTXXXXXXXXXXGKDTLIAQLQ-----LEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
+ + KD I LQ ++ Q H E + T+ D+ + KV
Sbjct: 658 FRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD---IQTDNSDIFQETKV 714
Query: 482 QEQLKQELNDEIKDVNVKD---LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
Q L E E D++ + L++ +K E +I LN++ + K + ++ + KL
Sbjct: 715 QS-LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLT 773
Query: 539 QM--QKTIDN---FSKVSDSN--KEIVRLTEELHHLS---QKVAELEEEKGNLQLHLVDY 588
Q+ QK ++ +++S ++ +++V L ++L + +KV + EK HL
Sbjct: 774 QIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKT- 832
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL-----HILQQKYDEVEDK 643
+ +M++ V K + L + K + ES D+ +E I+++K E+ D
Sbjct: 833 EYHKMMDI-VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEI-DA 890
Query: 644 LADISQ-----LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ Q LQ+ +E V+ Q + L + L ++ ++ K+Q+ T+++
Sbjct: 891 LSQKCQTLLAVLQTSSTGNEAGGVN-SNQFEELLQERDTLKQQVKKMEEWKQQVMTTVQN 949
Query: 699 LENDKEDI---MNKLQNYIQENMDLTDKLEKMSA---EKISELLAKINHEEQSKIQTQFG 752
++++ + +++LQ + + D KL+ + + K+ + Q Q Q
Sbjct: 950 MQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS 1009
Query: 753 IDAKIQERDLYIENIE--------SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
I +DL + ++ + L +S C V+ + L+++ ++L
Sbjct: 1010 IGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK 1069
Query: 805 YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
LQEK L + +A + +R +Q + KE Q Q LL+E
Sbjct: 1070 SLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDL 1129
Query: 865 LQISLSDMQQHYNA-LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI-VQKK 922
L + SD N K N +L T + ++ LE ++ ++ E++ ++ +
Sbjct: 1130 LIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRG 1189
Query: 923 KEIEDLEI-EFNTQIESAIRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
KE E + E N + +R+K+ + EK + + L+ + Q + L V+
Sbjct: 1190 KETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKS 1249
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYI--NEINKLNALLKQKDEEIIALNQKINNAQVS 1038
+ + + + Q E N + +L + ++E+ L + ++ S
Sbjct: 1250 MQEKTVVFQQERDQVMLALKQKQMENTALQNVVQRLRDKEFRSNQELERLRNHLLESEDS 1309
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI-LVREQDDQI-KELK 1096
Y E + A+ K+ +EE++ S +++ H +Q+ ++EQ + + K+
Sbjct: 1310 YTREALAAEDREAKLRKKVTVLEEKLVS-SSNAMENASHQASVQVESLQEQLNVVSKQRD 1368
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
ET L ++ + + +S M V +++++++ I E
Sbjct: 1369 ETALQLSVSQEQVKQYALSLANLQM------VLEHFQQEEKAMYSAELEKQKQLIAEWKK 1422
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E LQEC + + LT V +EQI +LK + E D++
Sbjct: 1423 NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1482
Query: 1217 VAELRSSISSAVDQ 1230
+ L +S VD+
Sbjct: 1483 LMSLANSSEGKVDK 1496
>AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 protein.
Length = 1357
Score = 128 bits (310), Expect = 1e-28
Identities = 238/1175 (20%), Positives = 499/1175 (42%), Gaps = 109/1175 (9%)
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL--- 448
+ L D + I K+ KL+ N ++ K++++S K T D L
Sbjct: 253 DLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLK-TMMFSEDEALCVVDLLKEK 311
Query: 449 --IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK 506
+ Q L+ E +LIH + + +A V+E D K + + + EK +
Sbjct: 312 SGVIQDALKKSSKGELTTLIHQLQEKDKL--LAAVKEDAAAT-KDRCKQLTQEMMTEKER 368
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK-EIVRLTEELH 565
S IT++ D I K ++ + ++ Q+ F +V + + EI L +E
Sbjct: 369 S-NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427
Query: 566 HLSQKVAELE---EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
L V+ E K + +L+ + D R++ +++ +K +++ + A E
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLV-NELTEKTGKLQQEEVQKKNA----EQA 482
Query: 623 KFDLVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
L +L +++++EV+ + ++ ++ Q + K V E ++ +L + + +
Sbjct: 483 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS 542
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH 741
+ L+ QL + + N +E + ++Q+ +++N L ++++ ++ ++ A +
Sbjct: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
Query: 742 EEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ 801
EE K+ I E+D I+ E L+ + R+ EE + +++ + L+ + +
Sbjct: 603 EELHKV---------IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQK 653
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL-EIEHENKE---LQKKNQI 857
L + E+ A E +++ + V D R++E+QL EI ++ +E L +N+
Sbjct: 654 LQALANEQAAAAHEL----EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKA 709
Query: 858 LLEENQNLQISLSD------MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRIT 911
L E Q LQ +S+ ++Q + EK + E Q+ E L I
Sbjct: 710 LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
Query: 912 HEHQTLIVQKKKEIEDLEIEFNTQIE--SAIRD-KKVLNEKYEKNIEYVTQLEAQLQEYK 968
E+ +L KE++DL+ + N Q+ S + + KKV++EK K LEA+L +
Sbjct: 770 TENSSLT----KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
N + + +E+ + E+ + ++K Q S +++ +L LLK K+E++ +
Sbjct: 826 NKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS------ITSKVQELQNLLKGKEEQMNTM 879
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+++ + E LA L++++EE + + + + QHN +
Sbjct: 880 K-----------AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN----LKEASS 924
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE 1148
Q +EL+ E + + E M+ + D ++ K Q E+
Sbjct: 925 ASQFEELEIVLKEKENELKRLEAML-----KERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
Query: 1149 EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+++++ Q S + EL K+I E++G +++ LK +E
Sbjct: 980 --LKQQNYQQASSFPPHEEL----LKVISER--EKEISGL----WNELDSLKDAVEHQRK 1027
Query: 1209 ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA---DFQKTEHELRVQLSAFE 1265
+N++L E +++S ++ + K+ Q EA + ++ +L ++S
Sbjct: 1028 KNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPS 1087
Query: 1266 S-KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ---EKYADVINQIE 1321
+ Y + L + +E E+V L++KL++ +E LQ EKY V+ + E
Sbjct: 1088 NLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETE 1147
Query: 1322 ----ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS--ILNINEENA 1375
L+ +E E+ + + Q ++++ ++ I N+ E
Sbjct: 1148 GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE 1207
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
L+ V + + + EL +L+ SE ++ E + Q N+
Sbjct: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
Query: 1436 NVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKI 1495
+R + E +K DL ++ + L +++ K+ + A T+ + S++ E + K
Sbjct: 1268 KLRTEQNERQKVAGDL-HKAQQSLELIQSKIVKAAGD-TTVIENSDVSPET---ESSEKE 1322
Query: 1496 TESVSLNKQVAELN---KALEEEVAKTNEMQTALE 1527
T SVSLN+ V +L +A+ +++ K E LE
Sbjct: 1323 TMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
Score = 96.3 bits (229), Expect = 8e-19
Identities = 193/1020 (18%), Positives = 441/1020 (43%), Gaps = 91/1020 (8%)
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAV-SSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
+ + + +Q +++E ++A + E+ + + S + L S++S +K++ +++L
Sbjct: 402 QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE--LNKLRQDYARLV 459
Query: 391 SET------LNQDTDKKINKNEIA-KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+E L Q+ +K N + A +L++ +Q + + + I ++
Sbjct: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K +A+ H + + V + + ++ + K+ +E + V+D++E
Sbjct: 520 SK--FVAKENEVQSLHSKLTDTL-VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE 576
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVRL 560
+ ++ + QI Q + +I A + + HK+ K KQ+++T D+ + D +
Sbjct: 577 QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD---RLTSK 633
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI-SLL 619
EEL + L+ E LQ L + + E +KM + + + +++ + L
Sbjct: 634 EEELKDIQNMNFLLKAEVQKLQA-LANEQAAAAHE---LEKMQQSVYVKDDKIRLLEEQL 689
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + ++E IL + ++ ++ + L S+Q ++ EQ++ K E
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-----VEQMEKCIQEKDEKL 744
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+E L L+ G I+ KE+ +N ++ EN LT +++ + A++ ++
Sbjct: 745 KTVEEL-LET----GLIQ--VATKEEELNAIRT---ENSSLTKEVQDLKAKQNDQVSFAS 794
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
EE K+ I E+D I+++E L ++ E+++ +D + ++
Sbjct: 795 LVEELKKV---------IHEKDGKIKSVEELLEAELLKVANKEKTV---QDLKQEIKALK 842
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
+++G+ EK + S T + EL N L + ++ L E E + K Q L
Sbjct: 843 EEIGNVQLEKAQQLS-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
EEN++L+ + ++ QH A++ + E + + +L+ LE+ LK E ++ +
Sbjct: 902 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK----ERESDLS 957
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEK-------YEKNIEYVTQLEAQLQEYKNNIE 972
K + ++D++ E N +S I K N + +E+ ++ +++ E ++ N ++
Sbjct: 958 SKTQLLQDVQDE-NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 1016
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+L VE K N +L +K+ + + + TE+ + + K+N K++ +++ A+ +
Sbjct: 1017 SLKDAVEHQRKKNNDLREKNWEAMEALAS--TEKMLQD--KVNKTSKERQQQVEAVELEA 1072
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
VS S L+ + L E++ +K+ + +EE+++L + ++
Sbjct: 1073 KEVLKKLFPKVS-VPSNLS-YGEWLHGFEKK----AKECMAGTSGSEEVKVL----EHKL 1122
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
KE E ++ K + +++ T + +V+ +KV E + I+
Sbjct: 1123 KEADEMHTLLQLECEKYKS-VLAETEGILQKLQRSVE-----QEENKWKVKVDESHKTIK 1176
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+ +Q EL+ ++ +E L E ++ ++ + + + ++ D
Sbjct: 1177 Q---MQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDL 1233
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
L +L S S AV Q E L K L + +TE R +++ K +Q L
Sbjct: 1234 LTELQKKLDDSYSEAVRQN--EELNLLKAQLNETLTKL-RTEQNERQKVAGDLHKAQQSL 1290
Query: 1273 DSVQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ +QS + +E S + + +KE +L + + ++ + ++ EK
Sbjct: 1291 ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1350
Score = 84.2 bits (199), Expect = 3e-15
Identities = 167/897 (18%), Positives = 374/897 (41%), Gaps = 77/897 (8%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN- 532
D + K + + K+ N + + + + + K ++ + +D++ N+++ S+
Sbjct: 53 DKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE-DDQVAPVPLNVVETSSSV 111
Query: 533 -HKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
+ K ++ QK + + K SD++K + E + Q E +
Sbjct: 112 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 171
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQ 649
+G SD K +E + R +A+ L + K + K + E+ D
Sbjct: 172 NG----SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPL 227
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-DLENDKEDIMN 708
+ + + + +D K+E+ +++ +++ Q GT K E DKE+
Sbjct: 228 IHATTYIPLMDNADSSPVVD-----KREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 282
Query: 709 KLQNYI----------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K ++++ E + + D L++ S I + L K + E + + Q +Q
Sbjct: 283 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGV-IQDALKKSSKGELTTLIHQ------LQ 335
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYT 817
E+D + ++ + + K R +L + + ++R + R D++G+ +E ++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-----NQILLEENQNLQISLSDM 872
+ E +E ++ ++ EN L+ NQ+ +++ L D
Sbjct: 396 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 455
Query: 873 QQHYNALVEKANRTDLAESESTKYQ---TQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ N L EK + E + + TQL+ +R E Q+ I ++ E E +
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 515
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIENLNMNVEELN 982
+ ++ + + + L+ K + QLE +L Q+ N E+L M V+++
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ N E + +Q+ +Q T + +L+ ++ +KD++I + + + S
Sbjct: 576 EQN-EALKAQIQQFHSQIAAQTSASVLA-EELHKVIAEKDKQIKQTEDSLASERDRLTSK 633
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ + + L+ +++Q ++ + + E++Q V +DD+I+ L+E +L
Sbjct: 634 EEELKD-IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE-QLQH 691
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE-RSVLQEQS 1161
E++ E I++ + + + + + Q ++ +++ +QE+
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTL----------VSEQPNKDVVEQMEKCIQEKD 741
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
KL T + T +IQ+ T EL N +++ L+ + + S V EL+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD-LKAKQNDQVSFASLVEELK 800
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES--------KYEQLLD 1273
I D + + EL + L + A+ +KT +L+ ++ A + K +QL
Sbjct: 801 KVIHEK-DGKIKSVEELLEAELL-KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL-- 856
Query: 1274 SVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
S+ S QE N + E Q+ +++ L++KE+ L N + D+ + E L++ +++
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 913
Score = 69.3 bits (162), Expect = 1e-10
Identities = 113/589 (19%), Positives = 246/589 (41%), Gaps = 52/589 (8%)
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
I+++ + + LL E+ A + M+ + + ++ +E+E
Sbjct: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
Query: 1068 SKQLLDSKQHNEELQIL---VREQ-DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
++ S Q +++Q+ VREQ + +I LK+ + T + S S
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESK----QSA 446
Query: 1124 DANNV--DXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N + D K+Q+EE +Q+++ ++ + +L +LQE + ++++
Sbjct: 447 ELNKLRQDYARLVNELTEKTGKLQQEE--VQKKNA-EQAATQLKVQLQEAERRWEEVQSY 503
Query: 1182 NTELTG-HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
+ T H+ Q+ ++ +K ++ + + L T+ + ++QR ++ E +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ-----LEQRLMQLMES-E 557
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTME--QVT 1293
Q +E Q ++ Q A +++ +Q + + T EE +K++ + Q+
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
Query: 1294 SLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR 1353
++ L + + L + +E+ D+ N +L++E++ + +L
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL--------ANEQAAAAHELE 669
Query: 1354 TENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
QS ++ + + EE Q + S+ + +E + L+ T E +
Sbjct: 670 KMQQSVYVKDDK--IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ-TLVSEQPN 726
Query: 1414 SEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY 1473
++ ++ + Q DE ++L+E I+ T KE EL +R +
Sbjct: 727 KDVVEQMEK----CIQEKDEKLKTVEELLE-TGLIQVAT--KEEELNAIRTENSSLTKEV 779
Query: 1474 ETMQ--KESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
+ ++ + ++ L+EEL I E K V EL LE E+ K + +++ +
Sbjct: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL---LEAELLKVANKEKTVQDLKQ 836
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
EI L +EI N+Q + +A I V + +G++EQ+ NTM L
Sbjct: 837 EIKALKEEIGNVQ-LEKAQQLSITSKVQELQNLLKGKEEQM-NTMKAVL 883
Score = 66.9 bits (156), Expect = 6e-10
Identities = 150/812 (18%), Positives = 331/812 (40%), Gaps = 43/812 (5%)
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
R ++ I D++ + ++K + ++ SE ++ +L + LAV D V
Sbjct: 43 REQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL 102
Query: 840 QLLEIE---HENKELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTK 895
++E E K+ +KK + +LEE + S + + + T +E+ ++K
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + ++ + +TL+V K++ E L + T+ ES KK ++K +
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQ-EALPLHQETKQESGSGKKKASSKKQKTENV 221
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+V + Y ++N + + + ++L+ K Q + Q T++ E +K N
Sbjct: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL-KPDQVEGIQKSG-TKKLKTETDKEN 279
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A +K KD + + + + + +S + Q K ++ + E+ + QL
Sbjct: 280 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQL---- 334
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L V+E K+ + +LT EM K ++ + ++
Sbjct: 335 QEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNT-ELTGHDV 1190
Q + +F Q R ++ + A L E L++ + QLE+ + EL
Sbjct: 394 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ 453
Query: 1191 VNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+N+L K L+Q + N +L+ + A ++R E+ ++ A+ E
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA-ERRWEEVQSYIRKRTAEHE 512
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
A Q + + + + +S + +L D++ S Q E + ME NK + + ++
Sbjct: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM----- 1362
++ E+ + QI+ S+I + A +TE+ +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+E+ + +I N LK ++ E ++ + +KD +I +
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQ 688
Query: 1423 YTITLTQRNDEFENVRQQ---LVEYEKRIEDLTYEKESELAILRLK--MHENANHYETMQ 1477
++ + +EF+ + Q L ++++ L E+ ++ + +++ + E +T++
Sbjct: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 1478 KESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
+ E +++ EELN TE+ SL K+V +L ++V+ + +E + I
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS----FASLVEELKKVIH 804
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
+ +I +++ ++ A K+ D KQ
Sbjct: 805 EKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Score = 54.4 bits (125), Expect = 3e-06
Identities = 138/734 (18%), Positives = 300/734 (40%), Gaps = 69/734 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXX 199
+L D+ +++ +K + L L + + +Q+ + KD I +
Sbjct: 636 ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
Query: 200 XXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE--AN 257
+ K ++ K+Q + E KD +++ K I+ KD ++ ++EE
Sbjct: 696 KMEEFKILNDQNKALKSEVQKLQT--LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
Query: 258 KLLEAARFE-----ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE 312
L++ A E I E+S L +E+ Q L ++ + E+ +I+
Sbjct: 754 GLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
Query: 313 KGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR 372
L A + ++ K + ++ L +I+ +E+ N + S + + L +
Sbjct: 813 VEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK 872
Query: 373 KSGRNTASKM----------KSPW---SQLSSETLNQDTDKKINKN--------EIAKLE 411
+ NT + W Q +E+L + N + +LE
Sbjct: 873 EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELE 932
Query: 412 MVIQSLNKDLVDKEYVISEKDTXXXXXX---XXXXGKDTLI-AQL-QLEHQQHMEGPSLI 466
+V++ +L E ++ E+++ ++ L +Q+ QL+ Q + + S
Sbjct: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDV------NVKDLIEKLKSAEEQIT----QLN 516
+ ++E K L EL D +KD DL EK A E + L
Sbjct: 993 PHEELLKVISEREKEISGLWNEL-DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQ 1051
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAE-LE 575
D+++ +K + +L+ K++ K + F KVS + + E LH +K E +
Sbjct: 1052 DKVNKTSKERQQQVEAVELEAKEVLKKL--FPKVSVPSN--LSYGEWLHGFEKKAKECMA 1107
Query: 576 EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
G+ ++ ++++ ++ E+D ++++E E ++ E L + + +
Sbjct: 1108 GTSGSEEVKVLEH---KLKEADEMHTLLQLE--CEKYKSVLAETEGILQKLQRSVEQEEN 1162
Query: 636 KYD-EVEDKLADISQLQSDQVCSEIKSVHLEEQ---IDALSASKKELALVIENLKLDKEQ 691
K+ +V++ I Q+QS SE + L + I+ L ++ L + +E ++++
Sbjct: 1163 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERST 1222
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
+++L++ ++ KL + E + ++L + A+ ++E L K+ EQ++ Q
Sbjct: 1223 YVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQ-LNETLTKL-RTEQNERQKVA 1280
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME---DRRYSLERKADQLGSYLQE 808
G K Q+ +E I+S++ K +E S E + ++ +Q + LQ+
Sbjct: 1281 GDLHKAQQS---LELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQ 1337
Query: 809 KQKAYSEYTIQEDE 822
+A ++ +E E
Sbjct: 1338 LLQAVNQQLTKEKE 1351
>Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein.
Length = 1937
Score = 128 bits (308), Expect = 2e-28
Identities = 216/1129 (19%), Positives = 461/1129 (40%), Gaps = 86/1129 (7%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
K++ LK E + +K+ +K K + E++ ++K K++ +L Q
Sbjct: 838 KIKPLLKSA-ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL---Q 893
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV------------- 586
+Q D+ + + +++++ +L ++V E EE+ + L
Sbjct: 894 VQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 587 --DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
D D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 954 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 645 ADISQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK 703
Q + D+V K+ LE+Q+D L S ++ + +L+ K +L G +K +
Sbjct: 1014 ----QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
D+ N + L +KLEK E IS L++KI E+ +IQ Q KI+E
Sbjct: 1070 MDMEN-------DKQQLDEKLEKKEFE-ISNLISKIEDEQAVEIQLQ----KKIKELQAR 1117
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
IE + E+ ++ + E+ + + + + ++ G + + + + +L
Sbjct: 1118 IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKL 1177
Query: 824 VNRL-AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
L + H+ +V + EL ++ L Q L+ S+++ + L
Sbjct: 1178 RRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSN 1237
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESA 939
A A+ K L D S LK E Q LI ++ ++ E++ Q++
Sbjct: 1238 AEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK 1297
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
L+ + + + + +L+ QL+E + +N + + ++ + +L+ + +++Q
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEE-ETKAKNALAHALQSSRHDCDLLREQYEEEQEG 1356
Query: 1000 SPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++ +++ N A + K E + I +++ A+ + + E + K
Sbjct: 1357 KAE-LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 1059 NMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
++E+ QR+ + +LD ++ N L ++Q + K L E K +E +T+ +
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE----ETQAELE 1471
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+S E S + + E +E LQ++ + L ++ E +
Sbjct: 1472 ASQKESRSLSTE------LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQ 1525
Query: 1175 IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
I +LE + ++ Q + + ++ LE + + + +++S + + ++ E
Sbjct: 1526 IHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1585
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-EETNKIV--TMEQ 1291
I +L + H E + E+R + A K + D + Q N++ ++
Sbjct: 1586 IDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRN 1645
Query: 1292 VTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIED-----EKVAFXXXXX 1339
+ Q L++ + HL +L+E+ A V + +L++EIE+ E+
Sbjct: 1646 YRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705
Query: 1340 XXXXXXXXXXXD-LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
L T+N S +++ ++++ +++++ + DA
Sbjct: 1706 EQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 1399 EAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDL 1451
EL + + E +K E T+ L R DE E + ++Q+ + E R+ +L
Sbjct: 1766 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1825
Query: 1452 TYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV-SLNKQV 1505
E E+E A+ L+ HE T Q E + + V +++L K+ V S +Q
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQA 1885
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
E + ++K ++Q LE E ++ L+ R +KI
Sbjct: 1886 EEAEEQSNANLSKFRKLQHELEEAEERAHIAESQVNKLRVKSREVHTKI 1934
Score = 109 bits (263), Expect = 6e-23
Identities = 213/1072 (19%), Positives = 444/1072 (41%), Gaps = 82/1072 (7%)
Query: 474 DVNEIAKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
+ + +A +E+ +Q + ++I+ + +K++ E+ + EE +N E+ A + + S
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEE----INAELTAKKRKLEDECSE 952
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELEEEKGNLQ-LHLVDYDS 590
K + ++ T+ K + + V+ LTEE+ L + +A+L +EK LQ H D
Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 591 GRMIESDV----------YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQ------ 634
+ E V +++ ++E E K LE K L +L + Q
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 635 ----QKYDE-VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
Q+ DE +E K +IS L S + + L+++I L A +EL IE + +
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELL--AKINHEEQS 745
+ DL + E+I +L+ + +K AE K+ L A + HE
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 746 KIQTQFGID--AKIQERDLYIENIESELSKYKSRICR----LEESIAVMEDRRYSLERKA 799
+ D A++ E+ ++ ++ +L K KS + L + + + +LE+
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
L + E + E ++L + A L +QL E + +L + Q
Sbjct: 1253 RSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST 1312
Query: 860 EENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
++ + L+ L + + NAL +++R D + +Y+ + ++ ++ L+R + +
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHD-CDLLREQYEEE-QEGKAELQRALSKANSE 1370
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV----TQLEAQLQEYKNNIEN 973
+ Q + + E I+ ++E A + ++ E+++E V LE Q +N +E+
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L ++VE N L K+Q ++ + + A L+ +E +L+ ++
Sbjct: 1431 LMLDVERSNAACAAL-----DKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ Y + E+ + +N+++E+ +++Q+ + + EL+ + ++ + +
Sbjct: 1486 KVKNVYEESLDQLET----LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKC 1541
Query: 1094 ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
E++ E ++ EG I+ +E ++ + VD LK
Sbjct: 1542 EIQAALEEAEASLEHEEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETM 1600
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK---LEQLNTEN 1210
+S L + N L+ L + +L + + E + ++ L++
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHL 1660
Query: 1211 DNLLSTVAELRSSISSAVDQRG----FEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
D+ L +L+ + + V++R EI ELW L Q E + E EL L A S
Sbjct: 1661 DDALRGQEDLKEQL-AIVERRANLLQAEIEELWAT-LEQTERSRKIAEQEL---LDA--S 1713
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE 1326
+ QLL + +S K+ V+ LQ+++++ + RN +EK I ++ E
Sbjct: 1714 ERVQLLHTQNTSLINTKKKL--ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEE 1771
Query: 1327 IEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
++ E+ DL Q EQ L ++ Q K +
Sbjct: 1772 LKKEQDT-SAHLERMKKNLEQTVKDL----QHRLDEAEQLALKGGKKQIQ-KLEARVREL 1825
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ +AEA H+ +K E+ +T E + + D + ++ ++ Y++
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHERRVK--ELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKR 1883
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQ-KESEIERVKL-IEELNVKIT 1496
+ E+ + + L+ R HE E ES++ ++++ E++ KI+
Sbjct: 1884 QAEEAEEQSNANLSKFRKLQHELEEAEERAHIAESQVNKLRVKSREVHTKIS 1935
Score = 107 bits (257), Expect = 3e-22
Identities = 221/1071 (20%), Positives = 448/1071 (41%), Gaps = 106/1071 (9%)
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS----QLQSDQVCSEIKS 661
+ LA++ K L E + L++E + LQ + D LAD QL +++ E K
Sbjct: 864 DELAKSEAKRKEL-EEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKI 922
Query: 662 VHL------EEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
+ EE+I+A L+A K++L LK D + L T+ +E +K NK++N
Sbjct: 923 KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 982
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ---FGIDAKIQER-DLYIENIESE 770
+E L + + K+S EK + L + + + +Q + I K + + + ++++E
Sbjct: 983 EEMAGLDETIAKLSKEK--KALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGS 1040
Query: 771 LSKYKSRICRLEESIAVME-DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
L + K LE + +E D + + E D +KQ+ + +E E+ N ++
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDM----ENDKQQLDEKLEKKEFEISNLISK 1096
Query: 830 LMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL---VEKA 883
+ D V ++K++ E++ +EL ++ + + SD+ + + +E+A
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1156
Query: 884 NRTDLAESE-STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
A+ E + K + + + L +L+ T +H+ ++ +K+ D E QI++ R
Sbjct: 1157 GGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRV 1216
Query: 943 K-KVLNEKYE---------KNIEYVTQ----LEAQLQEYKNNIENLNMNVEELNKMNLEL 988
K K+ EK E N E +++ LE + ++ + L EE ++ +L
Sbjct: 1217 KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDL 1276
Query: 989 IDKHVQKQQTQSPDYTEQYINE---INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD 1045
+ + QT++ +Y+ Q + +++L+ + ++I L ++ + ++
Sbjct: 1277 TAQRA-RLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHA 1335
Query: 1046 YESKLAQFTTKLENMEEEMQ-RVSKQLLDSKQHNEELQILVREQDDQI---KELKETKLT 1101
+S E EEE + + Q SK ++E Q + + D I +EL+E K
Sbjct: 1336 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1395
Query: 1102 FEMNIPKTEGMIISSTIEPMSDD------ANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
+ + E + + + S + N V+ ++++ ++
Sbjct: 1396 LAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDK- 1454
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
VL E K E + +L+TEL V +E ++Q LE L EN NL
Sbjct: 1455 VLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQ----LETLRRENKNLQQ 1510
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ--------KTEHE----LRVQLSA 1263
+++L I+ Q E+ ++ KQ + Q + + Q EHE LR+QL
Sbjct: 1511 EISDLTEQIAEGGKQI-HELEKIKKQ-VEQEKCEIQAALEEAEASLEHEEGKILRIQLEL 1568
Query: 1264 FESKYE---QLLDSVQSSTQEETNKIVTMEQVTS-LQNKLQDKEEHLRNLQEKYADVINQ 1319
+ K E ++ + + Q + N +E + S L +++ + + LR +++K +N+
Sbjct: 1569 NQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR-VKKKMEGDLNE 1627
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
+EI + ++A L ++ Q + L I E A L +
Sbjct: 1628 MEIQLNHA--NRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685
Query: 1380 SSXXXXXXXXXXXXRVND-AEAKVLELTHQLEL---KDSEIYQKTHEYTITLTQRNDEFE 1435
+ R AE ++L+ + +++L +++ + + ++Q E E
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE 1745
Query: 1436 NVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE------IERVKLIE 1489
V Q+ E++ + + L+ K + + H E M+K E R+ E
Sbjct: 1746 EVIQESRNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804
Query: 1490 ELNVK--ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE--IEIVTLNDE-----I 1540
+L +K + L +V EL +E E + E L E ++ +T E +
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1864
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD--NTMNKELLDAVPRAEL 1589
LQ++V +K++ + A + ++ + L + EL +A RA +
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERAHI 1915
Score = 103 bits (247), Expect = 5e-21
Identities = 174/961 (18%), Positives = 417/961 (43%), Gaps = 75/961 (7%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ +++ L +A LE E SLE
Sbjct: 983 EEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLE 1042
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++S +K +++EK + ++ L KIE
Sbjct: 1043 QEKKLRMDLERAKRKLEGDLK----LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIE 1098
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ + Q+++ KEL+ ++ +G E +A ++ S + K + + +++ +L
Sbjct: 1099 DEQAVEIQLQKKIKELQARIEELGEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1153
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS--EKDTXXXXXXXXXXGKDT 447
++NK A+ + + + L + + E +++ K +
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD-----LI 502
+ +LE ++ + +N E +++ E++ + L D++ ++ K+ LI
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273
Query: 503 E-------KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+L++ + ++ DE DA + + K ++++++ ++ +K ++
Sbjct: 1274 NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALA 1333
Query: 556 EIVRLT-EELHHLSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMIEME--- 606
++ + + L ++ E +E K LQ L +S E+D ++ E+E
Sbjct: 1334 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1393
Query: 607 -NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
LA+ +A +E+ Q+ +EVED + D+ + + + K + +
Sbjct: 1394 KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFD 1453
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
+ + +E +E + + L + ++N E+ +++L+ +EN +L ++
Sbjct: 1454 KVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEIS 1513
Query: 726 KMSAEKISE------LLAKINHE-EQSKIQTQFGI---DAKIQERDLYIENIESELSKYK 775
++ E+I+E L KI + EQ K + Q + +A ++ + I I+ EL++ K
Sbjct: 1514 DLT-EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVK 1572
Query: 776 SRICRL-----EESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
S + R EE + + +E L + ++ + A E +L N + +
Sbjct: 1573 SEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDL-NEMEIQ 1631
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEE----NQNLQISLSDMQQHYNALVEKANR- 885
++H + + L + + K+ Q+ L++ ++L+ L+ +++ N L +
Sbjct: 1632 LNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691
Query: 886 -TDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
L ++E ++ + L+++ + ++ H T ++ KK++E+ + +++E I++
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES 1751
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDY 1003
+ EK +K I + +L++ ++ +L E K NLE K +Q + ++
Sbjct: 1752 RNAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQL 1806
Query: 1004 T-EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
+ +I KL A +++ + E+ N++ NA+ + + +E ++ + T + E +
Sbjct: 1807 ALKGGKKQIQKLEARVRELEGEV--ENEQKRNAEA--VKGLRKHERRVKELTYQTEEDRK 1862
Query: 1063 EMQRVSKQL--LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
+ R+ + L +K + + Q E+ K KL E+ + I S +
Sbjct: 1863 NVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERAHIAESQVNK 1922
Query: 1121 M 1121
+
Sbjct: 1923 L 1923
Score = 98.3 bits (234), Expect = 2e-19
Identities = 150/765 (19%), Positives = 316/765 (41%), Gaps = 50/765 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + + + +L + E + KEL++K LL+E +LQ+ +Q +
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQSEAD 899
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+L + R + + + +++++ + E + KK+++ED E I+
Sbjct: 900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEE-EEEINAELTAKKRKLEDECSELKKDID 958
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 959 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEED 1018
Query: 995 KQQ--TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T++ EQ ++++ K+ ++ +K+ D E+ Q
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KLE E E+ + ++ D + +LQ ++E +I+EL E + K E
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 1113 --IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ L + E EF + R L+E A L E
Sbjct: 1139 RSDLSRELEEISERLEE----AGGATSAQVELNKKREAEFQKLRRDLEE--ATLQHEAMV 1192
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS---TVAELRSSISS 1226
+ +++ EL G + N +++ Q L+ + +L E D+L S +++ + ++
Sbjct: 1193 AALRKKHADSM-AEL-GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEK 1250
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQS-STQEETNK 1285
+++EL + Q+ T R+Q A E Y + LD + +Q +K
Sbjct: 1251 MCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGE--YSRQLDEKDALVSQLSRSK 1308
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ +Q+ L+++L+++ + L + ++LR + E+E+
Sbjct: 1309 QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ--------EGKAEL 1360
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN-AKCASLEK 1419
Query: 1406 THQL---ELKDSEI-YQKTHEYTITLTQRNDEFENV----RQQLVEYEKRIEDLTYEKES 1457
T Q E++D + ++++ L ++ F+ V +Q+ E + +E E S
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS 1479
Query: 1458 ---ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
EL ++ E+ + ET+++E++ + I +L +I E KQ+ EL K ++
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENK-NLQQEISDLTEQIAEG---GKQIHELEKIKKQ 1535
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1536 VEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1580
Score = 95.5 bits (227), Expect = 1e-18
Identities = 214/1126 (19%), Positives = 470/1126 (41%), Gaps = 111/1126 (9%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 906 ERCEQLIKNKIQLEAKIK-EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 350 ATMGTESKAVSSPSKK-GSPLISRKSGRNTASKMKSPWSQLSSETLN--QDTDKKIN--K 404
A + E A + K + SK K + +TL+ Q + K+N
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILT 1024
Query: 405 NEIAKLEMVIQSLNKDLVDKEYV-----ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQH 459
KLE + L L ++ + +++ D + QL+ +
Sbjct: 1025 KAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLE 1084
Query: 460 MEGPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIKDVNV-KDLIEKLKS---- 507
+ + ++ + ED + ++Q+++K +EL +EI+ + EK +S
Sbjct: 1085 KKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR 1144
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK-----TIDNFSKVSDSNKE----IV 558
E+I++ +E A +++ + + +++++ T+ + + V+ K+ +
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
L E++ +L + +LE+EK L++ D S S + +M E ++ +
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 619 LESQKFDLVQELHI----LQQKYDE----VEDKLADISQLQSDQVCSEIKSVHLEEQIDA 670
E ++ L+ +L LQ + E +++K A +SQL + S + L+ Q++
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEE 1324
Query: 671 LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
+ +K LA +++ + D + L ++ + K ++ L E K E + +
Sbjct: 1325 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ 1384
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
+ EL EE K Q ++QE + ++E + ++ + + RL+ + ED
Sbjct: 1385 RTEEL------EEAKKKLAQ-----RLQEAEEHVEAVNAKCASLEKTKQRLQNEV---ED 1430
Query: 791 RRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
+ER ++ + L +KQ K SE+ + +E L R + +L ++++
Sbjct: 1431 LMLDVER-SNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN 1489
Query: 847 ENKELQKKNQILLEENQNLQISLSDMQQHY----NALVEKANRTDLAESESTKYQTQLRD 902
+E + + L EN+NLQ +SD+ + + E E E + Q L +
Sbjct: 1490 VYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEE 1549
Query: 903 LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-TQLE 961
E++L+ HE + I++ + E+ ++ E + +I + L + + +E + + L+
Sbjct: 1550 AEASLE---HE-EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605
Query: 962 AQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
A+++ +N+ + +E +LN+M ++L H + +S Y N L
Sbjct: 1606 AEIRS-RNDALRVKKKMEGDLNEMEIQL--NHANRLAAES---LRNYRNTQGILKETQLH 1659
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSD-YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
D+ + Q+ Q++ + ++ ++++ + LE E + ++LLD+ +E
Sbjct: 1660 LDDAL--RGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDA---SE 1714
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
+Q+L Q L TK E ++ + + S +E + ++ N +
Sbjct: 1715 RVQLL----HTQNTSLINTKKKLENDVSQ-----LQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 1140 XXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
+ + ++E Q+ S L+ L +++ ++ + E L L G ++QI +
Sbjct: 1766 AMMAEELKKE--QDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKG----GKKQIQK 1817
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR 1258
L++++ +L E +N AE AV +G E + L + + +K L+
Sbjct: 1818 LEARVRELEGEVENEQKRNAE-------AV--KGLRKHERRVKELTYQTEEDRKNVLRLQ 1868
Query: 1259 VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ ++K + + + +E++N + + LQ++L++ EE
Sbjct: 1869 DLVDKLQAKVKSYKRQAEEA-EEQSN--ANLSKFRKLQHELEEAEE 1911
>AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein.
Length = 1635
Score = 127 bits (307), Expect = 3e-28
Identities = 244/1171 (20%), Positives = 499/1171 (42%), Gaps = 127/1171 (10%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA-EEQITQLNDEIDAAN-------- 523
E +N ++ EQLK + N E +++ IEK++ EEQI L ++DA
Sbjct: 109 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 168
Query: 524 --KNMIKVKSNHKLK-LKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
+N+I+ S H K + +Q+ + + +E+ L ++ S K E E K N
Sbjct: 169 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQ--EEVKELMCQIE-ASAKEHEAEINKLN 225
Query: 581 -LQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKA-----ISLLESQKFDLVQELHIL 633
L+ +LV E ++ KK E+ENL + A I + Q+ V++ ++
Sbjct: 226 ELKENLVKQCEAS--EKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQ--VV 281
Query: 634 QQKYDEVEDKLADISQLQS---DQVCSEIKSVHLEEQIDALSAS------KKELALVIEN 684
+K +ED L ++ S D+V + + ++ L+ ++DA +++L I
Sbjct: 282 NEKVKHLEDTLKELESQHSILKDEV-TYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE 340
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK-INHEE 743
L L KE+ I+ L+++ + + ++++ L++ ++ISEL ++ E
Sbjct: 341 LLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSE 400
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
+ K+ F I ++E+ EN++ E + I E +ME + L A G
Sbjct: 401 KEKLTLMFEIQG-LKEQ---CENLQQEKQE---AILNYESLREIMEILQTELGESA---G 450
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQ 863
QE + + EL +L + + + ++ EN++L + +++ E
Sbjct: 451 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE--- 507
Query: 864 NLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
L+ ++ ++Q+ + ++ D T L++LE + +T E I + K
Sbjct: 508 -LENTIKNLQEKNGVYLLSLSQRD----------TMLKELEGKINSLTEEKDDFINKLKN 556
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL----NMNVE 979
E+++ F+ + E R L +K E+ I+Y ++LE ++ E +E + N +
Sbjct: 557 SHEEMD-NFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ 615
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI-IALNQKINNAQVS 1038
+L K+ +++ K + + + + E NKL++ KQ ++ + L+QK V
Sbjct: 616 KLEKLMVQM--KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK---EDVI 670
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
++ E KL + +N+ + ++ Q L K +L ++E ++ E E
Sbjct: 671 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT---QLYGFLKEMGSEVSEDSEE 727
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
K +N+ + G ++ E + A D L++++E + +QE SV+Q
Sbjct: 728 KDV--VNVLQAVGESLAKINEEKCNLAFQRDEKV---------LELEKEIKCLQEESVVQ 776
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
+ +L + L++ + + L E+ Q + ++K+ E+ EN NLL V
Sbjct: 777 CE--ELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 834
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
E+ + S + E + K+H + QK + R +L + + SV++
Sbjct: 835 EVSQTCSKSEIHNEKEKCFI-KEHENLKPLLEQKELRDRRAELILLKDSLAKS-PSVKND 892
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
++ E++ +L+ + ++KEE + ++ +++ R E + K
Sbjct: 893 PLSSVKELE--EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLR 950
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DL +SYK + +L +++ QL R N+
Sbjct: 951 SEKDQLSASMR-DLIQGAESYKNL----LLEYEKQSEQLDVEKE-----------RANNF 994
Query: 1399 EAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
E ++ +LT QL L+ I + + + + Q++E ++ + E
Sbjct: 995 EHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKEL 1054
Query: 1456 ESELAILRLKMHENA---NHYETMQKESEIERVKL---IEELNV---KITESVSLNKQVA 1506
E+E K+ E+A N E +Q + + E+ +L ++EL + ++ +N ++A
Sbjct: 1055 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1114
Query: 1507 ELNKALEEEVAKTNEMQTALEN--QEIEIV-----TLNDEITNLQNMVRASSSKIQKHVS 1559
+ + ++E K +E+ QEI+I TL +EIT+LQ+ V+ K K
Sbjct: 1115 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1174
Query: 1560 FASDTKQGRDEQLDNTMNKELLDAVPRAELD 1590
TK+ + + +L A + EL+
Sbjct: 1175 LLVKTKKELADSKQAETDHLILQASLKGELE 1205
Score = 97.9 bits (233), Expect = 3e-19
Identities = 191/963 (19%), Positives = 380/963 (39%), Gaps = 81/963 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN----EKDQII-EAKNKATTXXXX 198
V L NTIK V + + +T + +L+ KIN EKD I + KN
Sbjct: 505 VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNF 564
Query: 199 XXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA-EWKDEKQRLLKDIESKDVRISSLEEAN 257
K + T + + + E + LK+ + D ++ L
Sbjct: 565 HKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQM 624
Query: 258 KLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK-TEIEEKGSL 316
K+L + +S E L +E + Q + +E T++E+K L
Sbjct: 625 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 684
Query: 317 EIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL-ISRKSG 375
+ L K LLE+ Q +L L MG+E VS S++ + + + G
Sbjct: 685 MVEEQDNLNK---LLENEQVQKLFVKTQLYGFLKEMGSE---VSEDSEEKDVVNVLQAVG 738
Query: 376 RNTASKMKSPWS---QLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKD 432
+ A + + Q + L + + K + E ++SL +D ++E V+ K+
Sbjct: 739 ESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRD-YEQEKVLLRKE 797
Query: 433 TXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDE 492
D L+ + +E +L+ E+V++ E ++
Sbjct: 798 LEEIQSEKEALQSD-LLEMKNANEKTRLENQNLL---IQVEEVSQTCSKSEIHNEKEKCF 853
Query: 493 IKD-VNVKDLIE--KLKSAEEQITQLNDEI----DAANKNMIKVK------SNHKLKLKQ 539
IK+ N+K L+E +L+ ++ L D + N + VK N + + K+
Sbjct: 854 IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 913
Query: 540 MQKTIDNFSKVS-DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV 598
++ I+ V+ + KE+ +E + +++ L EK L + D G ++
Sbjct: 914 KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNL 973
Query: 599 YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEV----EDKLADISQLQSDQ 654
+ + + + + E + DL ++L + + + ED LA I LQS+
Sbjct: 974 LLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1033
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
E++ + ++ A + KEL E KL KEQ N+ E++ +LQ
Sbjct: 1034 KLLEVQILEVQR---AKAMVDKEL----EAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1086
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
++ +LE + + L + + ++ + ++ K+ ++ IE++E E+
Sbjct: 1087 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE--LNQKLTNKNNKIEDLEQEIKIQ 1144
Query: 775 KSR-------ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
K + I L+ S+ E++ +++ + L + ++A +++ I + L L
Sbjct: 1145 KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGEL 1204
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
V + QL EI E ++ + + E++Q +LS QQ AL E+
Sbjct: 1205 EASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR---TLSAYQQRVTALQEECR--- 1258
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ----IESAIRDK 943
A++E T + ES R+ H L QK K + E E Q +E I
Sbjct: 1259 AAKAEQA---TVTSEFESYKVRV---HNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL 1312
Query: 944 KVLNEKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQS 1000
K+ + + N++ V++L+ E+ +E N ++E EL +K +Q +
Sbjct: 1313 KIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1372
Query: 1001 PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
Q ++++ N +L+ + ++ + Q + V + +L++ +L +
Sbjct: 1373 KSEHTQTVSQLTSQNEVLRN------SFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL 1426
Query: 1061 EEE 1063
+ E
Sbjct: 1427 KNE 1429
Score = 78.2 bits (184), Expect = 2e-13
Identities = 155/754 (20%), Positives = 318/754 (42%), Gaps = 99/754 (13%)
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
E+E E +EL+ K + E ++ +L++ L+EKA S + ++
Sbjct: 1 ELEKEIEELRSKP--VTEGTGDIIKALTERLDAL--LLEKAETEQQCLSLKKENIKMKQE 56
Query: 903 LESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+E ++ ++ H+ L + KEIE+L+ E DK L ++ E+ + +
Sbjct: 57 VEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLE 116
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
L QL+ N+ +N+ EE+ K+ P + EQ + +L+A
Sbjct: 117 LSEQLKFQNNSEDNVKKLQEEIEKIR---------------PGFEEQILYLQKQLDATTD 161
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
+K E + L I Y ++ + +L Q K + EE + + + +K+H
Sbjct: 162 EKKETVTQLQNIIEANSQHYQKNINSLQEELLQL--KAIHQEEVKELMCQIEASAKEHEA 219
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E+ L +++ +K+ + + E NI K + + + + +AN +
Sbjct: 220 EINKLNELKENLVKQCEAS----EKNIQKKYECELEN-LRKATSNANQDNQICSI----- 269
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+ +E F+++ V+ E+ L L+E + Q L E+T +N L
Sbjct: 270 ----LLQENTFVEQ--VVNEKVKHLEDTLKELES---QHSILKDEVT--------YMNNL 312
Query: 1200 KSKLE-QLNTENDNLLSTVAELRSSISS---AVDQRGFEIAELWKQHLAQREADFQKTEH 1255
K KLE D +L I+ A +++G I +L K LA F T
Sbjct: 313 KLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKL-KSELAGLNKQFCYTVE 371
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ ++ + + ++++ + + + ++ K E++T L ++Q +E NLQ++ +
Sbjct: 372 QHNREVQSLKEQHQKEISELNETFLSDSEK----EKLT-LMFEIQGLKEQCENLQQEKQE 426
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
I E LR +E + +Q ++ M++Q +++E
Sbjct: 427 AILNYESLREIMEILQTELGESAGKI--------------SQEFESMKQQQASDVHELQQ 472
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVL---ELTHQLELKDSEIYQKTHEYTITLTQRND 1432
+L +++ R+ K+L EL +LE + +K Y ++L+QR+
Sbjct: 473 KL-RTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD- 530
Query: 1433 EFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN 1492
L E E +I LT EK+ + L+ E N ++ ++E +LI EL
Sbjct: 531 ------TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE-----RLILELG 579
Query: 1493 VKITESVSLN----KQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
K+ +++ N ++V EL LEE + + ++ LE +++ L+++ L V+
Sbjct: 580 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVK 639
Query: 1549 ASSSKIQKHVSFASDTKQ-GRDEQLDNTMNKELL 1581
S +++ +S+ KQ RD ++ + ++++
Sbjct: 640 ---SLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 670
Score = 76.6 bits (180), Expect = 7e-13
Identities = 152/707 (21%), Positives = 290/707 (41%), Gaps = 72/707 (10%)
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
VE + ++ +KEL++ + ++E +NL+ L ++ Y+ +KAN L +
Sbjct: 57 VEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSE--DKAN---LQKQLEEAM 111
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
TQL +L LK + + + + ++EIE + F QI + +K L+ ++ E
Sbjct: 112 NTQL-ELSEQLK-FQNNSEDNVKKLQEEIEKIRPGFEEQI---LYLQKQLDATTDEKKET 166
Query: 957 VTQL----EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
VTQL EA Q Y+ NI +L + +L ++ E V++ Q +++ EIN
Sbjct: 167 VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE----EVKELMCQIEASAKEHEAEIN 222
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
KLN L + + + S ++ YE +L N ++ Q S L
Sbjct: 223 KLNELKE----------NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 272
Query: 1073 DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
++ + + V+ +D +KEL+ + + + + ++
Sbjct: 273 ENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE 332
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L +EE+ + E+ L+ + A LN Q CYT +E N E+ +
Sbjct: 333 DLEFKINELLLAKEEQGCVIEK--LKSELAGLNK--QFCYT----VEQHNREVQSLKEQH 384
Query: 1193 QEQINQL-KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
Q++I++L ++ L E L+ + L+ + ++ + A L + L + Q
Sbjct: 385 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEK--QEAILNYESLREIMEILQ 442
Query: 1252 KTEHELRVQLS-AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
E ++S FES +Q V Q+ + + N+LQ + E L + Q
Sbjct: 443 TELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ 502
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
E ++ N I+ L+ + L + K++ E I ++
Sbjct: 503 ELVPELENTIKNLQEK------------------NGVYLLSLSQRDTMLKEL-EGKINSL 543
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK---DSEIYQKTHEYTITL 1427
EE + E +LEL ++E +SE+ QK +E T L
Sbjct: 544 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 603
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
+ E + Q+L + +++ L+ +KE A E + YE K S E+ +L
Sbjct: 604 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA-------EVKSLYEENNKLSS-EKKQL 655
Query: 1488 IEELNVKIT--ESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
+L V ++ E V L + + +L K L+ V + + + LEN++++
Sbjct: 656 SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQ 702
>D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 127 bits (306), Expect = 4e-28
Identities = 227/1140 (19%), Positives = 476/1140 (41%), Gaps = 100/1140 (8%)
Query: 471 NTEDVNEIAKVQEQ---LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ E E+A ++E+ +K+ L E + K+L EK+ S ++ L ++ A N+
Sbjct: 844 SAETEKEMATMKEEFGRIKETL--EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
+ +K I +KV + N+ + E L+ K +LE+E L+ D
Sbjct: 902 DAEERCDQLIKNK---IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK---D 955
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL--- 1012
Query: 648 SQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-------DL 699
Q + D+V + KS V LE+Q+D L S ++ V +L+ K +L G +K DL
Sbjct: 1013 -QAEEDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL-LAKINHEEQSKI-QTQFGIDAKI 757
ENDK + KL+ ++ D+ + K+ E++ L L K E Q++I + + ++A+
Sbjct: 1072 ENDKLQLEEKLK---KKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
R +E + S+LS+ I E + + +K + + Q+ ++ E T
Sbjct: 1129 TAR-AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEAT 1184
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+Q + A+ H + E+ + LQ+ Q L +E ++ L D+ +
Sbjct: 1185 LQHE--ATAAALRKKH----ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238
Query: 878 ALVE-KANRTDLA---ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+++ KAN ++ E ++ +Y+ +L + + +L T + L + + LE E
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQLE-EKE 1297
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
I R K ++ E L+ QL+E + +N + + + + +L+ +
Sbjct: 1298 ALISQLTRGKLSYTQQME-------DLKRQLEE-EGKAKNALAHALQSARHDCDLL-REQ 1348
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+++T++ ++ +++ N A + K E + I +++ A+ + D E +
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 1053 FTTKLENMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
K ++E+ R+ + ++D ++ N L ++Q + K L E K +E +
Sbjct: 1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES--- 1465
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
S +E +A ++ ++ E F +E LQE+ + L +L
Sbjct: 1466 ------QSELESSQKEARSLSTELFKLKNAYEE-SLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
E + +LE + +L + Q + + ++ LE + ++++ I +
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1578
Query: 1229 DQRGFEIAELWKQHLAQREADFQKT----EHELRVQLSAFESKYEQLLDSVQSSTQEETN 1284
++ E+ + + H QR D +T E R ++ + K E L+ ++
Sbjct: 1579 AEKDEEMEQAKRNH--QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636
Query: 1285 KIV-TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
+QV SLQ+ L+D + L +L+E A V + +L++E+E+ +
Sbjct: 1637 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696
Query: 1337 XXXXXXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXX 1390
L ++N S +++ ++++ ++++++
Sbjct: 1697 TERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEK 1756
Query: 1391 XXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVE 1443
+ A EL + + E +K E TI L R DE E + ++QL +
Sbjct: 1757 AKKAITHAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Query: 1444 YEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITES 1498
E R+ +L E E+E ++ ++ E T Q E + + + +++L K+
Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
Query: 1499 V-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH 1557
V + +Q E + ++K ++Q L+ E ++ L+ R +K + H
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMH 1936
Score = 93.1 bits (221), Expect = 8e-18
Identities = 186/919 (20%), Positives = 398/919 (43%), Gaps = 85/919 (9%)
Query: 233 KDEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLEHSK-LAQELEQXXXXXXXXX 289
++ Q+ L D+++++ ++++L ++ LE E SLE K + +LE+
Sbjct: 1002 QEAHQQALDDLQAEEDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1061
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L ++SI +K ++EEK + ++ + KIE + L Q+++ KE + ++
Sbjct: 1062 K----LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARI 1117
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
+ E +A + K L S S ++ + T Q K + E K
Sbjct: 1118 EELEEELEAERTARAKVEKLRSDLS--RELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
+ ++ + +K + Q +LE ++ L V
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ-KLEKEKSEFKLELDDVT 1234
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVK---------DLI---EKLKSAEEQITQLND 517
+N E + + E++ + L D+ + VK D KL++ ++++ +
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQLE 1294
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELEE 576
E +A + + K ++ +++ +++ ++ K ++ ++ + L ++ E E
Sbjct: 1295 EKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETE 1354
Query: 577 EKGNLQLHLVDYDS-----GRMIESDVYKKMIEMENL----------AETRLKAI----S 617
K LQ L +S E+D ++ E+E AE ++A+ S
Sbjct: 1355 AKAELQRVLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLA--DISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE K L E+ L + A D Q D++ +E K + E Q + S+ K
Sbjct: 1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
+ +L E KL K +++ LE K + NK N +E DLT++L + + + EL
Sbjct: 1475 EARSLSTELFKL-KNAYEESLEHLETFKRE--NK--NLQEEISDLTEQLGE-GGKNVHEL 1528
Query: 736 LAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDR 791
E K++ Q + +A ++ + I + E ++ K+ I R L E ME
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA 1588
Query: 792 RYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDH-DRV---VEKQLLEI 844
+ + +R D L + L + ++ +E + ++ +N + + + H +R+ +KQ+ +
Sbjct: 1589 KRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL-AESESTKYQTQLRDL 903
+ K+ Q + + N +L+ +++ +++ N L +A +L A E T+ +L D
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL--QAELEELRAVVEQTERSRKLADR 1706
Query: 904 E----SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
E S ++ H T ++ +KK+++ + +++E A+++ + EK +K I +
Sbjct: 1707 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITHAAM 1766
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALL 1018
+ +L++ ++ +L E K N+E K +Q + ++ + ++ KL A +
Sbjct: 1767 MAEELKKEQDTSAHL-----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1821
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++ + E+ A QK N V M E ++ + T + E ++ + R+ + L+D
Sbjct: 1822 RELEGELEA-EQKRNAESVKGM---RKSERRIKELTYQTEEDKKNLLRL-QDLVD----- 1871
Query: 1079 EELQILVREQDDQIKELKE 1097
+LQ+ V+ Q +E +E
Sbjct: 1872 -KLQLKVKAYKRQAEEAEE 1889
Score = 87.0 bits (206), Expect = 5e-16
Identities = 144/764 (18%), Positives = 319/764 (41%), Gaps = 48/764 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + +++ L + E KEL++K LL+E +LQ+ + Q + N
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D + + +++++ L+ E + KK+++ED E I+
Sbjct: 902 ---DAEERCDQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKKDID 957
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1017
Query: 995 KQQTQSPDYT--EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T S EQ ++++ K+ ++ +K+ + D E+ Q
Sbjct: 1018 KVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQ 1077
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KL+ E ++ + + ++ D + +LQ ++E +I+EL+E +L E
Sbjct: 1078 LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEE-ELEAERTARAKVEK 1136
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
+ S + + + ++ K + E EF + R L+E A L E
Sbjct: 1137 LRSDLSRELEEISERLEEAGGATSVQIEMNK-KREAEFQKMRRDLEE--ATLQHEATAAA 1193
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ +++ EL G + N +++ Q L+ + + E D++ S + ++ + + +++
Sbjct: 1194 LRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA-KANLEKV 1250
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS----TQEETNKIV 1287
+ + ++ + E + Q++ ++ Q + +++ +L ++ +Q K+
Sbjct: 1251 SRTLEDQANEYRVKLE-EAQRSLNDFTTQRAKLQTENGELSRQLEEKEALISQLTRGKLS 1309
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
+Q+ L+ +L+++ + L + ++LR + E+E A
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA--------KAELQR 1361
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT- 1406
+E + E + EE + KK VN A+ LE T
Sbjct: 1362 VLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN-AKCSSLEKTK 1420
Query: 1407 HQL--ELKDSEI-YQKTHEYTITLTQRNDEFENV----RQQLVEYEKRIEDLTYEKES-- 1457
H+L E++D + ++++ L ++ F+ + +Q+ E + +E E S
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1480
Query: 1458 -ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEE 1515
EL L+ E+ H ET ++E++ L EE++ +TE + K V EL K ++
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENK----NLQEEIS-DLTEQLGEGGKNVHELEKVRKQL 1535
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ E+Q+ALE E + +I Q ++I++ ++
Sbjct: 1536 EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1579
Score = 83.8 bits (198), Expect = 5e-15
Identities = 184/1112 (16%), Positives = 461/1112 (41%), Gaps = 89/1112 (8%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXXXXXX 205
+ T+++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 861 IKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----ANKLL 260
+ + +M A + + +DE L KDI+ ++ ++ +E+ NK+
Sbjct: 921 VKEM--NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978
Query: 261 EAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEI 318
L+ +KL +E ++ + + + K ++E++ ++
Sbjct: 979 NLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLSKSKVKLEQQVD-DL 1036
Query: 319 ANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR- 376
E KK+ + LE ++ K + + + + + KK I++++ +
Sbjct: 1037 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKI 1096
Query: 377 ----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKD 432
A +++ + + + + + + AK+E + L+++L + + E
Sbjct: 1097 EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1156
Query: 433 TXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL------K 486
++ +++ + ++ + + +A++ EQ+ K
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1216
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
Q+L E + ++ ++ + S EQI + ++ ++ + + +++KL++ Q+++++
Sbjct: 1217 QKLEKEKSEFKLE--LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLND 1274
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
F+ + +L E LS+++ E E L + Y + + K+ +E E
Sbjct: 1275 FT------TQRAKLQTENGELSRQLEEKEALISQLTRGKLSYTQ----QMEDLKRQLEEE 1324
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
A+ L L+S + D +L+++Y+E + A++ ++ S + SE+ +
Sbjct: 1325 GKAKNAL--AHALQSARHD----CDLLREQYEEETEAKAELQRVLS-KANSEVAQCRTKY 1377
Query: 667 QIDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ DA L +KK+LA +++ + E + LE K ++LQN I++ M
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK----HRLQNEIEDLMVD 1433
Query: 721 TDKLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
++ +A +K KI E + K + ++++ ++ +EL K K+
Sbjct: 1434 VERSNAAAAALDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTELFKLKNAY 1490
Query: 779 CRLEESIAVMEDRRYSLERKADQL-------GSYLQEKQKAYSEYTIQEDELVNRL---- 827
E + + +L+ + L G + E +K + +++ EL + L
Sbjct: 1491 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A L + + + LE E+++K L E+++ ++ + + Q+ ++L +
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 888 LAESESTKYQTQLR-DLESNLKRITHEHQTLIVQKKKEIEDLE-IEFNTQIESAIRDKKV 945
+ +E + + ++ DL +++H ++ + + +K+++ L+ + +TQI+ + D
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANR-MAAEAQKQVKSLQSLLKDTQIQ--LDDAVR 1664
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM-NLELIDKHVQKQQTQSPDYT 1004
N+ ++NI V + LQ + + E K+ + ELI+ + Q S +
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQN-- 1722
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQ------VSYMSMVSDYESKLAQFTTKLE 1058
IN+ K++A L Q E+ Q+ NA+ +++ +M+++ K + LE
Sbjct: 1723 TSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITHAAMMAEELKKEQDTSAHLE 1782
Query: 1059 NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTI 1118
M++ M++ K L + +E QI ++ Q+++L+ E + + S
Sbjct: 1783 RMKKNMEQTIKDL--QHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVK 1840
Query: 1119 EPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQ 1177
+ + L++Q+ + +Q + + Q+ + + +K +
Sbjct: 1841 GMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1900
Query: 1178 LETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
++ E + + Q+N+L++K + +
Sbjct: 1901 VQHELDEAEERADIAESQVNKLRAKSRDIGAK 1932
Score = 83.8 bits (198), Expect = 5e-15
Identities = 180/909 (19%), Positives = 374/909 (41%), Gaps = 73/909 (8%)
Query: 222 QENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQX 281
QE+ + +E + +++L K + + S +E+ L + ++ +++ +ELE+
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARI-EELEEE 1123
Query: 282 XXXXXXXXXXXXXLAKQSIEPSCEEKTE-IEEKGSLEIANMTELTKKIELLEHLNCQIRQ 340
L + + EE +E +EE G + E+ KK E + ++
Sbjct: 1124 LEAERTARAKVEKL-RSDLSRELEEISERLEEAGGATSVQI-EMNKKRE------AEFQK 1175
Query: 341 TNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK 400
++LE AT+ E+ A + K + + ++K + SE + D
Sbjct: 1176 MRRDLEE--ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Query: 401 KINKNEIAKLEMVIQSLNKDLVDK--EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH-- 456
N +I K + ++ +++ L D+ EY + ++ T A+LQ E+
Sbjct: 1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT-----TQRAKLQTENGE 1288
Query: 457 -QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT-- 513
+ +E + + T + E LK++L +E K N L L+SA
Sbjct: 1289 LSRQLEEKEAL-ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNA--LAHALQSARHDCDLL 1345
Query: 514 --QLNDEIDA-ANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVR----LTEE 563
Q +E +A A + K+N ++ + K I ++ ++ K++ + E
Sbjct: 1346 REQYEEETEAKAELQRVLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405
Query: 564 LHHLSQKVAELEEEKGNLQLHL----VDYDSGRMIESDVYKKMIEMEN-LAETRLK---A 615
+ ++ K + LE+ K LQ + VD + + + KK + LAE + K +
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 616 ISLLESQKFD---LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
S LES + + L EL L+ Y+E + L + ++ + EI L EQ+
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR-ENKNLQEEISD--LTEQLGEGG 1522
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKI 732
+ EL V + L+++K +L +++ E E K+ E + ++E+ AEK
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582
Query: 733 SEL-LAKINHEE-QSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICRLEESIAVME 789
E+ AK NH+ +QT + + + L + + +E +L++ + ++ A
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAA--- 1639
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE----IE 845
+++ L S L++ Q + D+L +A++ + +++ +L E +E
Sbjct: 1640 ----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+ + ++ L+E ++ +Q+ S N + +SE + + R+ E
Sbjct: 1696 QTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEE 1755
Query: 906 NLKR-ITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ 963
K+ ITH KK++ +E +E I+D + ++ E+ + + Q
Sbjct: 1756 KAKKAITHAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA--LKGGKKQ 1813
Query: 964 LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
LQ+ + + L +E K N E + K ++K + + + T Y E +K N L Q
Sbjct: 1814 LQKLEARVRELEGELEAEQKRNAESV-KGMRKSERRIKELT--YQTEEDKKNLLRLQDLV 1870
Query: 1024 EIIALNQKINNAQVSYMSMVSDYE-SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
+ + L K Q ++ SK + +L+ EE Q+ + + ++
Sbjct: 1871 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1930
Query: 1083 ILVREQDDQ 1091
+ D++
Sbjct: 1931 AKQKMHDEE 1939
Score = 74.5 bits (175), Expect = 3e-12
Identities = 191/923 (20%), Positives = 382/923 (41%), Gaps = 86/923 (9%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+K+ ++ K++ + L LQ+K+ E IE +
Sbjct: 1074 DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAK 1133
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1134 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1189
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEE-KGSLE--I 318
+ +H+ EL + KQ +E E K E+++ ++E I
Sbjct: 1190 TAAALRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEFKLELDDVTSNMEQII 1241
Query: 319 ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR-N 377
L K LE + R +E + L T+ + + + + S + K +
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQLEEKEALIS 1301
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXX 435
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEEGKAKNALAH---ALQSARHDCDLLREQY---EEETEA 1355
Query: 436 XXXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIK 494
K ++ +AQ + +++ TE++ E K Q Q+ + ++
Sbjct: 1356 KAELQRVLSKANSEVAQCRTKYE--------TDAIQRTEELEEAKKKLAQRLQDAEEAVE 1407
Query: 495 DVNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFS 548
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S
Sbjct: 1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1467
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ S KE L+ EL L EE +L+ + + + SD+ +++ E
Sbjct: 1468 ELESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
K LE +K +L L + + E K+ +QL+ +Q+ +EI+ L E+
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKD 1582
Query: 669 DALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
+ + +K+ V+++L+ LD E N+ + K++ + E +
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAE------TRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636
Query: 727 MSAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
M+AE ++ + QS ++ TQ +D ++ D ENI + LEE
Sbjct: 1637 MAAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1691
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
AV+E S + +L + Q +S+ T ++ A L VE+ + E
Sbjct: 1692 AVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECR 1751
Query: 846 HENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQ 897
+ ++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1752 NAEEKAKKAITHAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK 1811
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI--- 954
QL+ LE+ ++ + E L ++K+ E ++ + E I++ E+ +KN+
Sbjct: 1812 KQLQKLEARVRELEGE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDKKNLLRL 1866
Query: 955 -EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NK
Sbjct: 1867 QDLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNK 1921
Query: 1014 LNALLKQKDEEIIALNQKINNAQ 1036
L A K +D I QK+++ +
Sbjct: 1922 LRA--KSRD---IGAKQKMHDEE 1939
>AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein.
Length = 1583
Score = 126 bits (304), Expect = 7e-28
Identities = 243/1171 (20%), Positives = 499/1171 (42%), Gaps = 127/1171 (10%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA-EEQITQLNDEIDAAN-------- 523
E +N ++ EQLK + N E +++ IEK++ EEQI L ++DA
Sbjct: 57 EAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVT 116
Query: 524 --KNMIKVKSNHKLK-LKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
+N+I+ S H K + +Q+ + + +E+ L ++ S K E E K N
Sbjct: 117 QLQNIIEANSQHYQKNINSLQEELLQLKAIHQ--EEVKELMCQIE-ASAKEHEAEINKLN 173
Query: 581 -LQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKA-----ISLLESQKFDLVQELHIL 633
L+ +LV E ++ KK E+ENL + A I + Q+ V++ ++
Sbjct: 174 ELKENLVKQCEAS--EKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQ--VV 229
Query: 634 QQKYDEVEDKLADISQLQS---DQVCSEIKSVHLEEQIDALSAS------KKELALVIEN 684
+K +ED L ++ S D+V + + ++ L+ ++DA +++L I
Sbjct: 230 NEKVKHLEDTLKELESQHSILKDEV-TYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE 288
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK-INHEE 743
L L KE+ I+ L+++ + + ++++ L++ ++ISEL ++ E
Sbjct: 289 LLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSE 348
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
+ K+ F I ++E+ EN++ E + I E +ME + L A G
Sbjct: 349 KEKLTLMFEIQG-LKEQ---CENLQQEKQE---AILNYESLREIMEILQTELGESA---G 398
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQ 863
QE + + EL +L + + + ++ EN++L + +++ E
Sbjct: 399 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE--- 455
Query: 864 NLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
L+ ++ ++Q+ + ++ D T L++LE + +T E I + K
Sbjct: 456 -LENTIKNLQEKNGVYLLSLSQRD----------TMLKELEGKINSLTEEKDDFINKLKN 504
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL----NMNVE 979
E+++ F+ + E R L +K E+ I+Y ++LE ++ E +E + N +
Sbjct: 505 SHEEMD-NFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ 563
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI-IALNQKINNAQVS 1038
+L K+ +++ K + + + + E NKL++ KQ ++ + L+QK V
Sbjct: 564 KLEKLMVQM--KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQK---EDVI 618
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
++ E KL + +N+ + ++ Q L K +L ++E ++ E E
Sbjct: 619 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT---QLYGFLKEMGSEVSEDSEE 675
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
K +N+ + G ++ E + A D L++++E + +QE SV+Q
Sbjct: 676 KDV--VNVLQAVGESLAKINEEKCNLAFQRDEKV---------LELEKEIKCLQEESVVQ 724
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
+ +L + L++ + + L E+ Q + ++K+ E+ EN NLL V
Sbjct: 725 CE--ELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 782
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
E+ + S + E + K+H + QK + R +L + + SV++
Sbjct: 783 EVSQTCSKSEIHNEKEKCFI-KEHENLKPLLEQKELRDRRAELILLKDSLAKS-PSVKND 840
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
++ E++ +L+ + ++KEE + ++ +++ R E + K
Sbjct: 841 PLSSVKELE--EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLR 898
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DL +SYK + +L +++ QL R N+
Sbjct: 899 SEKDQLSASMR-DLIQGAESYKNL----LLEYEKQSEQLDVEKE-----------RANNF 942
Query: 1399 EAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
E ++ +LT QL L+ I + + + + Q++E ++ + E
Sbjct: 943 EHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKEL 1002
Query: 1456 ESELAILRLKMHENA---NHYETMQKESEIERVKL---IEELNV---KITESVSLNKQVA 1506
E+E K+ E+A N E +Q + + ++ +L ++EL + ++ +N ++A
Sbjct: 1003 EAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELELVKKDAQQTTLMNMEIA 1062
Query: 1507 ELNKALEEEVAKTNEMQTALEN--QEIEIV-----TLNDEITNLQNMVRASSSKIQKHVS 1559
+ + ++E K +E+ QEI+I TL +EIT+LQ+ V+ K K
Sbjct: 1063 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1122
Query: 1560 FASDTKQGRDEQLDNTMNKELLDAVPRAELD 1590
TK+ + + +L A + EL+
Sbjct: 1123 LLVKTKKELADSKQAETDHLILQASLKGELE 1153
Score = 98.3 bits (234), Expect = 2e-19
Identities = 191/963 (19%), Positives = 380/963 (39%), Gaps = 81/963 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN----EKDQII-EAKNKATTXXXX 198
V L NTIK V + + +T + +L+ KIN EKD I + KN
Sbjct: 453 VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNF 512
Query: 199 XXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA-EWKDEKQRLLKDIESKDVRISSLEEAN 257
K + T + + + E + LK+ + D ++ L
Sbjct: 513 HKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQM 572
Query: 258 KLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK-TEIEEKGSL 316
K+L + +S E L +E + Q + +E T++E+K L
Sbjct: 573 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 632
Query: 317 EIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL-ISRKSG 375
+ L K LLE+ Q +L L MG+E VS S++ + + + G
Sbjct: 633 MVEEQDNLNK---LLENEQVQKLFVKTQLYGFLKEMGSE---VSEDSEEKDVVNVLQAVG 686
Query: 376 RNTASKMKSPWS---QLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKD 432
+ A + + Q + L + + K + E ++SL +D ++E V+ K+
Sbjct: 687 ESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRD-YEQEKVLLRKE 745
Query: 433 TXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDE 492
D L+ + +E +L+ E+V++ E ++
Sbjct: 746 LEEIQSEKEALQSD-LLEMKNANEKTRLENQNLL---IQVEEVSQTCSKSEIHNEKEKCF 801
Query: 493 IKD-VNVKDLIE--KLKSAEEQITQLNDEI----DAANKNMIKVK------SNHKLKLKQ 539
IK+ N+K L+E +L+ ++ L D + N + VK N + + K+
Sbjct: 802 IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 861
Query: 540 MQKTIDNFSKVS-DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV 598
++ I+ V+ + KE+ +E + +++ L EK L + D G ++
Sbjct: 862 KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNL 921
Query: 599 YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEV----EDKLADISQLQSDQ 654
+ + + + + E + DL ++L + + + ED LA I LQS+
Sbjct: 922 LLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 981
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
E++ + ++ A + KEL E KL KEQ N+ E++ +LQ
Sbjct: 982 KLLEVQILEVQR---AKAMVDKEL----EAEKLQKEQKIKEHATTVNELEELQVQLQKQK 1034
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
++ +LE + + L + + ++ + ++ K+ ++ IE++E E+
Sbjct: 1035 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE--LNQKLTNKNNKIEDLEQEIKIQ 1092
Query: 775 KSR-------ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
K + I L+ S+ E++ +++ + L + ++A +++ I + L L
Sbjct: 1093 KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGEL 1152
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
V + QL EI E ++ + + E++Q +LS QQ AL E+
Sbjct: 1153 EASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR---TLSAYQQRVTALQEECR--- 1206
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ----IESAIRDK 943
A++E T + ES R+ H L QK K + E E Q +E I
Sbjct: 1207 AAKAEQA---TVTSEFESYKVRV---HNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL 1260
Query: 944 KVLNEKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQS 1000
K+ + + N++ V++L+ E+ +E N ++E EL +K +Q +
Sbjct: 1261 KIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1320
Query: 1001 PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
Q ++++ N +L+ + ++ + Q + V + +L++ +L +
Sbjct: 1321 KSEHTQTVSQLTSQNEVLRN------SFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL 1374
Query: 1061 EEE 1063
+ E
Sbjct: 1375 KNE 1377
Score = 80.2 bits (189), Expect = 6e-14
Identities = 141/689 (20%), Positives = 293/689 (42%), Gaps = 85/689 (12%)
Query: 907 LKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
+K+ + T + KE+E I + +IE+ + + KY E L+ QL+E
Sbjct: 1 MKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS---EDKANLQKQLEE 57
Query: 967 YKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
N L+ ++ N N++ + + ++K + P + EQ + +L+A +K E
Sbjct: 58 AMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIR---PGFEEQILYLQKQLDATTDEKKET 114
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L I Y ++ + +L Q K + EE + + + +K+H E+ L
Sbjct: 115 VTQLQNIIEANSQHYQKNINSLQEELLQL--KAIHQEEVKELMCQIEASAKEHEAEINKL 172
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
+++ +K+ + + E NI K + + + + +AN + +
Sbjct: 173 NELKENLVKQCEAS----EKNIQKKYECELEN-LRKATSNANQDNQICSI---------L 218
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
+E F+++ V+ E+ L L+E + Q L E+T +N LK KLE
Sbjct: 219 LQENTFVEQ--VVNEKVKHLEDTLKELES---QHSILKDEVT--------YMNNLKLKLE 265
Query: 1205 -QLNTENDNLLSTVAELRSSISS---AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
D +L I+ A +++G I +L K LA F T + +
Sbjct: 266 MDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKL-KSELAGLNKQFCYTVEQHNRE 324
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ + + ++++ + + + ++ K E++T L ++Q +E NLQ++ + I
Sbjct: 325 VQSLKEQHQKEISELNETFLSDSEK----EKLT-LMFEIQGLKEQCENLQQEKQEAILNY 379
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
E LR +E + +Q ++ M++Q +++E +L ++
Sbjct: 380 ESLREIMEILQTELGESAGKI--------------SQEFESMKQQQASDVHELQQKL-RT 424
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVL---ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENV 1437
+ R+ K+L EL +LE + +K Y ++L+QR+
Sbjct: 425 AFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD------ 478
Query: 1438 RQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITE 1497
L E E +I LT EK+ + L+ E N ++ ++E +LI EL K+ +
Sbjct: 479 -TMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE-----RLILELGKKVEQ 532
Query: 1498 SVSLN----KQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ N ++V EL LEE + + ++ LE +++ L+++ L V+ S
Sbjct: 533 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVK---SL 589
Query: 1554 IQKHVSFASDTKQ-GRDEQLDNTMNKELL 1581
+++ +S+ KQ RD ++ + ++++
Sbjct: 590 YEENNKLSSEKKQLSRDLEVFLSQKEDVI 618
Score = 76.6 bits (180), Expect = 7e-13
Identities = 152/707 (21%), Positives = 290/707 (41%), Gaps = 72/707 (10%)
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
VE + ++ +KEL++ + ++E +NL+ L ++ Y+ +KAN L +
Sbjct: 5 VEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSE--DKAN---LQKQLEEAM 59
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
TQL +L LK + + + + ++EIE + F QI + +K L+ ++ E
Sbjct: 60 NTQL-ELSEQLK-FQNNSEDNVKKLQEEIEKIRPGFEEQI---LYLQKQLDATTDEKKET 114
Query: 957 VTQL----EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
VTQL EA Q Y+ NI +L + +L ++ E V++ Q +++ EIN
Sbjct: 115 VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE----EVKELMCQIEASAKEHEAEIN 170
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
KLN L + + + S ++ YE +L N ++ Q S L
Sbjct: 171 KLNELKE----------NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 220
Query: 1073 DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
++ + + V+ +D +KEL+ + + + + ++
Sbjct: 221 ENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE 280
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L +EE+ + E+ L+ + A LN Q CYT +E N E+ +
Sbjct: 281 DLEFKINELLLAKEEQGCVIEK--LKSELAGLNK--QFCYT----VEQHNREVQSLKEQH 332
Query: 1193 QEQINQL-KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
Q++I++L ++ L E L+ + L+ + ++ + A L + L + Q
Sbjct: 333 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEK--QEAILNYESLREIMEILQ 390
Query: 1252 KTEHELRVQLS-AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
E ++S FES +Q V Q+ + + N+LQ + E L + Q
Sbjct: 391 TELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ 450
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
E ++ N I+ L+ + L + K++ E I ++
Sbjct: 451 ELVPELENTIKNLQEK------------------NGVYLLSLSQRDTMLKEL-EGKINSL 491
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK---DSEIYQKTHEYTITL 1427
EE + E +LEL ++E +SE+ QK +E T L
Sbjct: 492 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 551
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
+ E + Q+L + +++ L+ +KE A E + YE K S E+ +L
Sbjct: 552 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA-------EVKSLYEENNKLSS-EKKQL 603
Query: 1488 IEELNVKIT--ESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
+L V ++ E V L + + +L K L+ V + + + LEN++++
Sbjct: 604 SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQ 650
>X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein.
Length = 3259
Score = 125 bits (302), Expect = 1e-27
Identities = 259/1372 (18%), Positives = 579/1372 (42%), Gaps = 118/1372 (8%)
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQRL--LKDIESK-DVRISSLEEANKLLEAARFEIS-L 269
T ++TK E ++ + + + LK + + +V SL++ LE+++ +I+ L
Sbjct: 1328 TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK---LESSQLQIAGL 1384
Query: 270 EHSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSC---EEKTEIEEKGSLEIANMTELT 325
EH + L +L++ L+ Q E + +TEI E+ L A T+L
Sbjct: 1385 EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK-GSPLISRKSGRNTASKMKS 384
+ + + Q++ E++ K +G ES+A +K + LISRK + KS
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA---LKENKS 1501
Query: 385 PWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXG 444
+LS L + T +++ K+ +A +E + + NK EKDT
Sbjct: 1502 LQEELS---LARGTIERLTKS-LADVESQVSAQNK----------EKDTVLGRLALLQEE 1547
Query: 445 KDTLIAQLQ---LEHQQHMEGPSLIHVGTN--TEDVNEIAKVQEQLKQELNDEIKDVNVK 499
+D LI ++ LE+Q + + TED ++ K E LK E + K
Sbjct: 1548 RDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK 1607
Query: 500 DLIEKLKSAEEQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++L+ E + Q + + + A + V++ + K + K + ++ K++
Sbjct: 1608 H--KELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQ 1665
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
+E+ + +K+ + + K L L + E+D + E+ +T + +
Sbjct: 1666 EAEQEMEEMKEKMRKFAKSKQQKILELEE-------END--RLRAEVHPAGDTAKECMET 1716
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
L S + +EL ++ +Y+ + K + + D + E++ + + + + + E
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMS-EKDSLSEEVQDLKHQIEDNVSKQANLEA 1775
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+N E+ +I +++ + + E++ ++ S
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835
Query: 739 INHEEQ-SKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
N+ +Q +++ + G++ + Q+ + + +E+E + S+I + + ++++ +
Sbjct: 1836 NNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMN 1895
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
Q+ L K ++D+L RL M+ + + + + Q KN+
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERL---MNQLAELNGSIGNYCQDVTDAQIKNE 1952
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+L E +NL+ +S++++ LV++ + + + + Q E K E Q
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLN--EKYEKNIEYVTQLEAQLQEYKNNIENL 974
L+ +K++E++ L+ + IR ++ ++ E+ K +E+V Q E+Q ++ + ENL
Sbjct: 2013 LLKEKQQEVKQLQ-------KDCIRYQEKISALERTVKALEFV-QTESQ-KDLEITKENL 2063
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
VE K EL V TQS + + + KL L+ E + ++
Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSE--AARVLADNLKLKKELQSNKESV---KSQMKQ 2118
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ E K + +NM+E++ + ++ + ++ E+Q+ + ++D ++++
Sbjct: 2119 KDEDLERRLEQAEEK---HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Query: 1095 LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV-DXXXXXXXXXXXXLKVQEEEEFIQE 1153
L+E ++ T+ + ++ + DD + V D ++ +EEE ++E
Sbjct: 2176 LQE-----NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230
Query: 1154 R--SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
SVL++Q +++ ++E I +LE + ++ + Q+ Q + L EN
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEH-DKQIWESKAQTEVQLQQ--KVCDTLQGENK 2287
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHE-------LRVQLS 1262
LLS + E R S+ ++ +EL K L +K + + +R Q +
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 1263 AFES---KYEQLLDSVQSSTQEETNKI---VTMEQ---VTSLQNKLQDKEEHLRNLQEKY 1313
++ YEQL +Q+S +E T+++ + M++ ++ L K + + + L++++
Sbjct: 2348 DIQNSKFSYEQLETDLQAS-RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
I ++E L S+ E+E + L+T + Q Q+ + + +
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ-QKAQLDSFVKS 2465
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
+ L+ R + +L + +++++ ++ + N E
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
Query: 1434 FENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN 1492
+ +L++Y + + +T + + +L +++ +N KE E + KL E
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN--------KELENKYAKLEE--- 2574
Query: 1493 VKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
K+ ES N+ + AL+EE ++ +E+ ++ I L ++T LQ
Sbjct: 2575 -KLKESEEANEDLRRSFNALQEE---KQDLSKEIESLKVSISQLTRQVTALQ 2622
Score = 120 bits (289), Expect = 4e-26
Identities = 291/1528 (19%), Positives = 634/1528 (41%), Gaps = 142/1528 (9%)
Query: 93 SLANTLKQKEILMEKIKQYKE---LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSN 149
SL+ K K++ +E ++ + L +T++R V H+S+
Sbjct: 800 SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 859
Query: 150 TIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXX 209
++E ALS ++++ M+ +L+ + + Q IE K++ T
Sbjct: 860 KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 919
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISL 269
++ ++E + + +K+++ +D E + +E + + ++ E+
Sbjct: 920 EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH 979
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
E L +E EQ L Q + EE ++++ EI ++E T++ E
Sbjct: 980 EFDLLKKENEQRKRKLQAALINRKELL-QRVSRLEEELANLKDESKKEIP-LSE-TERGE 1036
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ E + NKE K T + + + + R + + Q
Sbjct: 1037 VEED------KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
Query: 390 SS--ETLNQDTDKKIN-----KNEIAKLEMVIQSL---NKDLVDKEYVISEKDTXXXX-- 437
+ + +NQ K N + EI++ + +IQ L N D D + V K+T
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 438 -XXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K L + L LE ++ L T+ + + + K QE+ ++ L +E+K
Sbjct: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI--LKKAQEK-ERHLREELK- 1206
Query: 496 VNVKDLIEKLKSAEEQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
KD +L+ ++ ++ N+ I D + I+V+ + KL + ++ S
Sbjct: 1207 -QQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ-ESCSSTPGLE 1264
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS--GRMIESDVYKKMIEME-NLAET 611
+ + + TE+ HH +Q V E + H D + G + + ++ E+E E
Sbjct: 1265 EPLFKATEQ-HH-TQPVLE-SNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1321
Query: 612 RLKAISLLESQKFDLVQELHILQQKYD----EVED--KLADISQLQSDQVCSEIKSVHLE 665
LK +S S+ +E+ LQ++ + E+E ++ +++ ++ + +++S L+
Sbjct: 1322 ELK-VSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ 1380
Query: 666 ----EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT 721
E + L EL +I + D L G + ++KE + K+Q I E DL
Sbjct: 1381 IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL----SEKEAALTKIQTEIIEQEDLI 1436
Query: 722 DKLE---KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
L +M A++ E + ++ E Q I + + + +++ L K
Sbjct: 1437 KALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKE-- 1494
Query: 779 CRLEESIAVMEDRRYSLER-KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
L+E+ ++ E+ SL R ++L L + + S ++D ++ RLA+L +
Sbjct: 1495 -ALKENKSLQEE--LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE----- 1546
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE-SESTKY 896
E+ L E + L+ NQ L ++L+++L + + LV++ ++ +EST++
Sbjct: 1547 ERDKLITEMDRSLLE--NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1604
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
Q + ++L+ + +++Q + + + +E+ ++K+ L K
Sbjct: 1605 QEKHKELQKEYE--------ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMN----LELIDKHVQKQQTQSP--DYTEQYINE 1010
+ E QLQE + +E + + + K LEL +++ + + P D ++ +
Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1716
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE-NMEEEMQRVSK 1069
+ NA +K++ E + + ++ S MS ++ ++E N+ ++ +
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEAT 1776
Query: 1070 QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIP--KTEGMIISSTIEPMSDDA 1125
+ D++ + E Q + E ++Q T+ T ++P K+ +S D+
Sbjct: 1777 EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFS-SHDEI 1835
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
NN L EEE + + Q + NT L + TK +L+ L E+
Sbjct: 1836 NNYLQQIDQLKERIAGL----EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1891
Query: 1186 TGHDVVNQE------QINQLKSKLEQLNTE-NDNLLSTVAELRSSISSAVD-----QRGF 1233
T +++NQ+ ++ +LK E+ + + L++ +AEL SI + Q
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN 1951
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKY-EQLLDSVQSSTQEETNKIVTMEQV 1292
E+ E ++L + ++ ++ + +L + + ES+ ++ L+ +Q + +E NK
Sbjct: 1952 ELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK----SHA 2007
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL 1352
LQ L++K++ ++ LQ+ +I L + + + F +
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTV--KALEF-----------------V 2048
Query: 1353 RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK 1412
+TE+Q ++ ++++ E KK+ ++A A+V L L+LK
Sbjct: 2049 QTESQKDLEITKENLAQAVEHR---KKAQAELASFKVLLDDTQSEA-ARV--LADNLKLK 2102
Query: 1413 DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANH 1472
E+ + Q++++ E +Q E + + EK L ++ + E
Sbjct: 2103 -KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE 2161
Query: 1473 YETMQKESEIERVKLIEELNVKITESVSLNKQVAEL----NKALEEEVAKTNEMQTALEN 1528
+ + + E +L E L+ +T+ + K ++ L ++ ++E + A+++
Sbjct: 2162 IQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS 2221
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+E EI D + L++ +R S +++
Sbjct: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEE 2249
Score = 116 bits (278), Expect = 9e-25
Identities = 285/1536 (18%), Positives = 618/1536 (40%), Gaps = 141/1536 (9%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKA--TTXXXXXXXX 202
T L KE D + LQV++ M+ ++ E+ K QI A +
Sbjct: 1441 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1500
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDI----ESKDVRISSLEEANK 258
T +++TK + + + EK +L + E +D I+ ++ +
Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS-- 1558
Query: 259 LLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCE--EK-TEIEEKGS 315
LLE S E KLA LE L I S E EK E++++
Sbjct: 1559 LLENQSLSSSCESLKLA--LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE 1616
Query: 316 LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR--- 372
+ + + ++ + E ++H+ +RQ +EL KL + K ++ +
Sbjct: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676
Query: 373 ------KSGRNTASKMKSPWSQLSSE------TLNQDTDKKINKNEIAKLEMVIQSLNKD 420
KS + +++ +L +E T + + ++ N K E+ + +
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1736
Query: 421 LVDKEY--VISEKDTXXXXXXXXXXG-KDTLIAQLQLEH-QQHMEGPSLIHVGTN----- 471
+ K++ ++SEKD+ +D + Q LE ++H ++ GT
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS 531
TE+ + ++ E K N + K S+ ++I +ID K I
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSAN--PAVSKDFSSHDEINNYLQQIDQL-KERIAGLE 1853
Query: 532 NHKLKLKQMQKTIDN-----FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL-QLHL 585
K K K+ +T++N S++S + E+ L EE+ ++ +++EE + +L
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ +E + ++ E+ + ++ + + L E+ L++ E+E++
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLEND-- 702
+ + + +V SEI+ +LE+ Q K A ++ L +K+Q +K L+ D
Sbjct: 1974 QLVK-EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKDCI 2029
Query: 703 -KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK-INHEEQSKIQ-TQFGI---DAK 756
++ ++ L+ ++ ++ + E E LA+ + H ++++ + F + D +
Sbjct: 2030 RYQEKISALERTVKA-LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQ 2088
Query: 757 IQERDLYIENIE--SELSKYKSRI-CRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
+ + +N++ EL K + ++++ +E R E K + +QEK A
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL 2148
Query: 814 SEYTIQEDELVNRLAVLMDH-DRVVEK----------QLLEIEHENKELQKKNQILLEEN 862
+ +E + + V ++ D+ V++ QL LQ +++E
Sbjct: 2149 RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEA 2208
Query: 863 QNLQISLSD-MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ------ 915
+ + SD +Q + K + + + + + + +L+ N+ R+ H+ Q
Sbjct: 2209 KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKA 2268
Query: 916 -TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
T + ++K + L+ E N ++ S + + + L Y + + +LE++L+ K+ + +L
Sbjct: 2269 QTEVQLQQKVCDTLQGE-NKELLSQLEETRHL---YHSSQNELAKLESELKSLKDQLTDL 2324
Query: 975 NMNVEELN--KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+ ++E+ K NLE I + + S EQ ++ L + EEI QKI
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENM-EEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+S++S E + +L ++E++ + L ++ N L+ ++ D+
Sbjct: 2385 -------ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
Query: 1092 IKELKETKLTFEMNIPKTEGMIIS--STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+L ET T + + + + S ++ + +D + + + + E+++
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSI-ILEKDQ 2496
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL--------KS 1201
IQE + ++ KL E++ + + L + N +L + +E +NQ+ K
Sbjct: 2497 LIQEAAA---ENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553
Query: 1202 KLE---QLNTENDNLLSTVAE-LRSSISSAVD-QRGFEIAELWKQHLAQREADFQKTEHE 1256
LE Q N E +N + + E L+ S + D +R F + KQ L++ + + +
Sbjct: 2554 LLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
Query: 1257 LRVQLSAFESKYEQLLDSVQSST-QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L Q++A + + L Q +EE +++ + +S Q ++ + EE L +Q++ A
Sbjct: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL--FSSSQKRIAELEEELVCVQKEAAK 2671
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
+ +IE +++ E + + +M EQ +L + +EN
Sbjct: 2672 KVGEIE---DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEM-EQKLLMVTKENK 2727
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK------THEYTITLTQ 1429
L + A ++ EL + + E+ Q E L++
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE 2787
Query: 1430 RNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE---------- 1479
+ + + + +++ K+ +L L ++ ++ N ++ K
Sbjct: 2788 TAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDH 2847
Query: 1480 --SEIERVKLIEELNVKITESVSLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
+E+E+ + EE + S + +V L KA+ + + L+N + + + +
Sbjct: 2848 LWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQI 2907
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
N EIT L + K +F ++ R E L
Sbjct: 2908 NQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943
Score = 113 bits (272), Expect = 5e-24
Identities = 277/1471 (18%), Positives = 595/1471 (40%), Gaps = 141/1471 (9%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDV---RISSLEEANKLLEAARFEI 267
E+ K + K+ +EA+ + E R + +I D+ R SS EE+ + +
Sbjct: 495 EELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ--DVLENTF 552
Query: 268 SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
S +H +L+ L + L + E + E + +E +E + + K
Sbjct: 553 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMK 612
Query: 328 IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS 387
+ LE E E+ L + E + S+ + +G S +
Sbjct: 613 V-FLEDTGQDFPLMPNE-ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670
Query: 388 QLSSET----LNQDTDKKINKNEIAKLEMVIQSLN----KDLVDKEYVISEKDTXXXXXX 439
LS+ +QD +++ K++I +LE+ K+L +K IS +
Sbjct: 671 SLSAVPDIGQCHQDELERL-KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFK 729
Query: 440 XXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
+ L E Q + + + TE ++ +++ L + D +
Sbjct: 730 KNADNNSSAFTALSEERDQLLS--QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQ 787
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNM-IKVKSNH----KLKLKQMQKTIDNF-SKVSDS 553
+ L + EQI L+ I+A +K++ I+V N +L+ + I + S++ +
Sbjct: 788 TAHDNLLT--EQIHSLS--IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNK 843
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM--------IESDVYKKMIEM 605
E++ E + H+S KV EL + +L + D + ++ + +K ++
Sbjct: 844 ESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV 903
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED-KLADISQLQSDQVCSEIKSVHL 664
++ + + + L +KF L E+ L+++ + + + A Q++ D S +
Sbjct: 904 TEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 963
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+E A SK+EL + LK + EQ ++ ++++++ ++ +E +L D+
Sbjct: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEE 783
+K +E ++ ++++K ++ + +K QE ++Y++ SE I + LEE
Sbjct: 1024 KKEIPLSETER-GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1082
Query: 784 SIA-------VMEDRRYSLERKADQ---LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
+A +++ +L+ K +Q L + + E Q + + + +V +
Sbjct: 1083 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
Query: 834 DRVVEKQLL--EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN------R 885
+ VV EH EL++K L +E + LQ L + A+++KA R
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202
Query: 886 TDLAESES--TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
+L + + + Q Q + + I + + L +Q ++ I D ++ Q ES
Sbjct: 1203 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI-DGKLPSTDQQESCSSTP 1261
Query: 944 KVLNEKYEKNIEYVTQ--LEAQL-QEYKNNIENLN--------------MNVEELNKMNL 986
+ ++ ++ TQ LE+ L ++ ++ E+ + + E K+ L
Sbjct: 1262 GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1321
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINK-------LNALLKQKDEEIIALNQKINNAQVSY 1039
EL + T+ + Q +INK L + + + +L QK+ ++Q+
Sbjct: 1322 ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI 1381
Query: 1040 MSM--VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ + + + KL + + EE++ +S QL + + ++Q + EQ+D IK L
Sbjct: 1382 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL-H 1440
Query: 1098 TKLTFEMNIPKTEGMIISSTIE--PMSDDANNVDXXXXXXXXXXXXLKVQ--EEEEFIQE 1153
T+L EM + + I +E M + L+ +E ++E
Sbjct: 1441 TQL--EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETL----NTE---LTGHDVVNQEQINQLKSKLEQL 1206
LQE+ + ++ + +E+ N E + G + QE+ ++L +++++
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELR----VQ 1260
EN +L S+ L+ ++ + + + E+ K ++Q+ EL+ +
Sbjct: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1618
Query: 1261 LSAFES------KYEQLLDSVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKY 1313
L ++E+ + + ++++V+ QE K+ + E + +LQ+ E+ + ++EK
Sbjct: 1619 LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKM 1678
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ E+E+E L + N S K+ E+ + E
Sbjct: 1679 RKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELER----VKME 1734
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE-LTHQLELKDSEIYQKTHEYTITLTQRND 1432
L K V D + ++ + ++ Q L+ +E + T TQ +
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTNVTEEGTQ-SI 1793
Query: 1433 EFENVRQQLVEYEKR---IEDLTYEKESELAILR-LKMHENANHYETMQKESEIERVKLI 1488
E Q + R E + K + A+ + H+ N+Y ++++ +
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY--------LQQIDQL 1845
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT--NLQN- 1545
+E + E NK E ++ LE E N + + + ++ E+ L +E+T NL N
Sbjct: 1846 KERIAGLEEEKQKNK---EFSQTLENE---KNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
Query: 1546 MVRASSSKIQKHVSFASDTKQGRDEQLDNTM 1576
++ S++ K A + K +E+L N +
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMNQL 1930
Score = 108 bits (259), Expect = 2e-22
Identities = 252/1173 (21%), Positives = 471/1173 (40%), Gaps = 135/1173 (11%)
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLND----------- 517
G + D N A + +L QE + E + +D+ E+L AE+ + +L D
Sbjct: 18 GDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQ 77
Query: 518 -------EIDAANKNMIKVKSNHKLKLKQMQKTIDNF---------------SKVSDSNK 555
E AA+ + K+K + K KL + K I+ ++S +K
Sbjct: 78 KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK 137
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMIEMENLAETRLK 614
E+ + K+ E EE LQ L + + +S ++ + M+ + + +
Sbjct: 138 SSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEE 197
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
IS L++Q Q QQ E + + +L D++ + L Q D +
Sbjct: 198 FISTLQAQ-LSQTQAEQAAQQVVREKDARFETQVRLHEDEL------LQLVTQADVETEM 250
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+++L ++ L+ +E L G + ++ + +L Q N L+ +L++M AE +
Sbjct: 251 QQKLRVLQRKLEEHEESLVGRAQVVDL----LQQELTAAEQRNQILSQQLQQMEAEHNTL 306
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
E+SKI + ++ ++ ER L N++ E+ + + ++ A +E R +
Sbjct: 307 RNTVETEREESKILLE-KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSA 365
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
LE+K + ++EK EL + L D + +K LQ K
Sbjct: 366 LEQKHK---AEMEEKTSHILSLQKTGQELQSACDALKDQN-------------SKLLQDK 409
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKRITHE 913
N+ ++ Q +Q +QQ + + NR L + E T QT D+ + +T E
Sbjct: 410 NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE-TASQTSFPDVYNEGTQAVTEE 468
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ I +K + +LE E + S+I + + L + EK +T LEAQ N
Sbjct: 469 N---IASLQKRVVELENEKGALLLSSI-ELEELKAENEKLSSQITLLEAQ-----NRTGE 519
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK-LNALL---KQKDEEIIALN 1029
+ V E++ +++ +K + D E ++ +K L+ LL K+ EEI L
Sbjct: 520 ADREVSEIS--IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK 577
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
++ + +D+E L Q +++ ME E K + + ++ ++ E+
Sbjct: 578 LQLQGKRAE----EADHE-VLDQ--KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEES 630
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
KE T + E + + +E S + + ++E
Sbjct: 631 SLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDG-----DKSLSAVPDIGQCHQDE 685
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE---QINQLKSKLEQL 1206
+ +S + E + + QE Y K L+ E++ + + +E + S L
Sbjct: 686 LERLKSQILELELNFH-KAQEIYEK--NLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742
Query: 1207 NTENDNLLSTVAELR--SSISSAVDQRGFEIAELWKQ----HLAQREADFQKTE--HELR 1258
+ E D LLS V EL + + + V Q +AE +Q + +Q D TE H L
Sbjct: 743 SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLS 802
Query: 1259 VQLSAFESKYEQL---LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
++ + + K E L LD VQ E++ I SLQ++LQ+KE + E+
Sbjct: 803 IEAKSKDVKIEVLQNELDDVQLQFSEQSTLI------RSLQSQLQNKESEVLEGAERVRH 856
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
+ +++E L + +++ +T + +Q+ E S ++ E+
Sbjct: 857 ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEIS-FSMTEKMV 915
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
QL + ++N L + E E ++ +E + L Q DE
Sbjct: 916 QLNEEKFSLGVEIKTLKEQLN--------LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967
Query: 1436 NVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIER--VKLIEELNV 1493
Q E + DL +KE+E +L+ N E +Q+ S +E L +E
Sbjct: 968 PAGQISKEELQHEFDL-LKKENEQRKRKLQA-ALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV---TLNDEITNLQNMVRAS 1550
+I S + +V E ++E + +E + QEIEI T++++ LQ++ +
Sbjct: 1026 EIPLSETERGEVEE-----DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
Query: 1551 SSKIQKHVSFASDTKQGRDEQLDNTMNKELLDA 1583
K+ F + KQ D T +LL A
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQA 1113
Score = 102 bits (244), Expect = 1e-20
Identities = 245/1311 (18%), Positives = 531/1311 (40%), Gaps = 132/1311 (10%)
Query: 319 ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
A +T L K IE ++ + T + E +L+ S +K + K
Sbjct: 102 AKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKE--EL 159
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
S +++ +Q +E Q E ++ +Q + + + +S+
Sbjct: 160 ISTLQAQLTQAQAE---QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
Q++L + ++ + TE ++ +Q +L++ + V
Sbjct: 217 QVVREKDARFETQVRLHEDELLQ--LVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 499 KDLIEKLKSAEEQITQ-LNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS-KVSDSNKE 556
DL+++ +A EQ Q L+ ++ +++ + + ++ + ++ +V++
Sbjct: 275 VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS 334
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
L EE+HHL ++ E+ G Q L S +E ++ AE K
Sbjct: 335 FHNLQEEMHHLLEQF----EQAGQAQAELESRYSA-----------LEQKHKAEMEEKTS 379
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
+L QK QEL Q D ++D+ + + Q +++Q +++ E D L K
Sbjct: 380 HILSLQKTG--QEL---QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE--DQLQQKSK 432
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNK-LQNYIQENM-DLTDKLEKMSAEKISE 734
E++ + L L + + + D+ N+ Q +EN+ L ++ ++ EK +
Sbjct: 433 EISQFLNRLPLQQHETAS-----QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGAL 487
Query: 735 LLAKINHEE----QSKIQTQFGIDAKIQERDLYIENIESELSKY---KSRICRLEESIAV 787
LL+ I EE K+ +Q + + Q R + SE+S R EES
Sbjct: 488 LLSSIELEELKAENEKLSSQITL-LEAQNRTGEADREVSEISIVDIANKRSSSAEESGQD 546
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
+ + +S + K +L L E ++A E + +L + A DH+ + +K++ ++E E
Sbjct: 547 VLENTFSQKHK--ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 848 NKELQKKNQILLEENQ------NLQISLSDMQ------QHYNALVEKANRTDLA-ESEST 894
K L + Q N + SL ++ +H + E+ + D E +ST
Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKST 664
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKV------- 945
K Q + L S + I HQ + + K +I +LE+ F+ +I D+K
Sbjct: 665 K-QDGDKSL-SAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN 722
Query: 946 -LNEKYEKNIEY----VTQLEAQLQEYKNNIENLNMNVE---ELNKMNLELIDKHVQKQ- 996
L E+++KN + T L + + + ++ L+M E ++ ++ + L + Q++
Sbjct: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRL 782
Query: 997 QTQSPDYTEQYINE-INKLNALLKQKDEEIIALNQKINNAQVSY---MSMVSDYESKLAQ 1052
+S + + E I+ L+ K KD +I L ++++ Q+ + +++ +S+L
Sbjct: 783 DYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQN 842
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+++ E ++ +S ++ + Q + ++ + + D + E K T + I + +
Sbjct: 843 KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE--EEFIQERSVLQEQSAKLNTELQE 1170
+ + M++ ++ LK Q + + E+ ++++ L++
Sbjct: 903 VTEISFS-MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961
Query: 1171 CYTKIIQLETLNTELTGH--DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
Y ++ ++ E H D++ +E Q K KL+ LL V+ L +++
Sbjct: 962 NYDEMSPAGQISKEELQHEFDLLKKEN-EQRKRKLQAALINRKELLQRVSRLEEELANLK 1020
Query: 1229 DQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT 1288
D+ EI L + + E D + E+ + SK +++ ++ + E K V
Sbjct: 1021 DESKKEI-PLSETERGEVEEDKENKEYSEK----CVTSKCQEIEIYLKQTISE---KEVE 1072
Query: 1289 MEQV-TSLQNKLQDKEEH---LRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
++ + L+ KL +E+ ++ + + D NQI++L++EI + +
Sbjct: 1073 LQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDA 1132
Query: 1345 XXXXXXDLRTE-----------NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXX 1393
L E ++ +K E+ IL + +E QL+K
Sbjct: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
Query: 1394 RVNDAEAKVLELTHQLELK-DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
+ + E + E ELK + Y + E +++ E EN+ QL + + ++ + +
Sbjct: 1193 KAQEKERHLRE-----ELKQQKDDYNRLQE---QFDEQSKENENIGDQLRQLQIQVRE-S 1243
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV-----KITESVSL---NKQ 1504
+ + + E + K +E + + E N+ +E S
Sbjct: 1244 IDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTS 1303
Query: 1505 VAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ 1555
VA++ L+E A+ E++ + + E+ ++E+ LQ + +I+
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354
Score = 89.8 bits (213), Expect = 7e-17
Identities = 161/840 (19%), Positives = 342/840 (40%), Gaps = 63/840 (7%)
Query: 320 NMTELTKKIELLEHLNCQI----RQTNKELENKLA-TMGTESKAVSSPSKKGSPLISRKS 374
+M EL I LEH + QI QT +L+ K+ T+ E+K + S ++ L S
Sbjct: 2246 HMEELKINISRLEH-DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYH--S 2302
Query: 375 GRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTX 434
+N +K++S L + + + K + LE +I+ D+ + ++ + +T
Sbjct: 2303 SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2362
Query: 435 XXXXXXXXXGKDTLIAQLQLEHQQHMEGPS-LIHVGT---NTEDVNEIAKVQEQLKQELN 490
I + + + G I V + EI +++ L QE
Sbjct: 2363 LQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2422
Query: 491 DEI--KDVNVK------DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH--------K 534
+ I ++ N K L+E LK+ +++ Q ++D+ K+M ++++ +
Sbjct: 2423 ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ 2482
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
L+ + + ++ + ++ E +L EE+ L + +L E L L+ Y +
Sbjct: 2483 LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED--L 2540
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
+ K + + L E +L+ LE++ L ++L ++ +++ + + + D
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD- 2599
Query: 655 VCSEIKSV-----HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK 709
+ EI+S+ L Q+ AL + L L LK+ +E+++ + ++ I
Sbjct: 2600 LSKEIESLKVSISQLTRQVTALQ-EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2658
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+ + + K+ ++ +K+ + L ++H+ + ++ E + +E
Sbjct: 2659 EEELVCVQKEAAKKVGEIE-DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT-----IQEDELV 824
+L L I SL+ D L E ++ Y ++E L+
Sbjct: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 825 NRL--AVLMDH----DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
NR A+L + + E L +E N++L K++ LL + L+ S + +Q A
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2837
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
+ N D +E K+ R E +R + T + + ++ +
Sbjct: 2838 MASLQNERDHLWNELEKF----RKSEEGKQRSAAQPSTSPAEVQS-LKKAMSSLQNDRDR 2892
Query: 939 AIRDKKVLNEKYEKNIEYVTQL---EAQLQEYKNNIENLNMNVEELNKMNL----ELIDK 991
+++ K L ++Y + + +T+L +AQLQEY++ + + EEL + NL EL
Sbjct: 2893 LLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQL 2952
Query: 992 HVQKQQTQSPD--YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++K + + EQY+ I+ + L I L + Q + +
Sbjct: 2953 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ +N+ E + + QL DS + + ++ +++ + +L E K T + + T
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDT 3072
Score = 83.8 bits (198), Expect = 5e-15
Identities = 261/1481 (17%), Positives = 594/1481 (40%), Gaps = 119/1481 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
++ + + ++EK+ +S LQ ++ + + E ++ + K +
Sbjct: 145 EIEKIKHKLQEKEELISTLQAQLTQAQAE--QPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 203 XXXXXXXXXEDTKQQMTKMQE-NFIAMEAEWKDEKQRLLK--DIESK---DVRI--SSLE 254
E QQ+ + ++ F +DE +L+ D+E++ +R+ LE
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE 262
Query: 255 EANKLLEAARFEISLEHSKL--AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE 312
E + L + L +L A++ Q + ++E EE + E
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE 322
Query: 313 KGSLEIANMTELTKKI-ELLEHLNCQIRQTNK---ELENKLATMGTESKAVSSPSKKGSP 368
K LE+A + E + HL Q Q + ELE++ + + E K + +K S
Sbjct: 323 KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSAL--EQKHKAEMEEKTSH 380
Query: 369 LIS-RKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE-IAKLEMVIQSLNKDLVD--K 424
++S +K+G+ S + Q +S+ L ++ + + I +LE +Q +K++
Sbjct: 381 ILSLQKTGQELQSACDALKDQ-NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLN 439
Query: 425 EYVISEKDTXXXXXXXXXXGKDTL------IAQLQ-----LEHQQHMEGPSLIHV----G 469
+ + +T + T IA LQ LE+++ S I +
Sbjct: 440 RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499
Query: 470 TNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
N + ++I ++ Q + E + E+ ++++ D+ K S+ E+ Q D ++ K
Sbjct: 500 ENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ--DVLENTFSQKHK 557
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY 588
S L++K+ Q+ I F K+ K E+ L QK + E +G + + +
Sbjct: 558 ELSVLLLEMKEAQEEIA-FLKLQLQGKRAEEADHEV--LDQKEMKQMEGEGIAPIKMKVF 614
Query: 589 --DSGR----MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
D+G+ M + +E E A T ++ + E D EL +Q D+
Sbjct: 615 LEDTGQDFPLMPNEESSLPAVEKEQ-ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
+ DI Q D++ +KS LE +++ A + + E K + L I++ + +
Sbjct: 674 AVPDIGQCHQDEL-ERLKSQILELELNFHKAQEIYEKNLDEKAK-EISNLNQLIEEFKKN 731
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE----QSKIQTQFGIDAKIQ 758
++ + +E L +++++S ++EL A++ E +++ Q + +++
Sbjct: 732 ADNNSSAFTALSEERDQLLSQVKELSM--VTELRAQVKQLEMNLAEAERQRRLDYESQTA 789
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+L E I S + KS+ ++E ++D + ++ + S + Q SE +
Sbjct: 790 HDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE-VL 848
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+ E V ++ VE+ + + E+ K +Q+LLE+ ++++ +QQ
Sbjct: 849 EGAERVRHIS------SKVEELSQALSQKELEITKMDQLLLEKKRDVET----LQQ---T 895
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNL--KRITHEHQTLIVQKKKEIEDLEIEFNTQI 936
+ EK + T+ QL + + +L + T + Q ++ + +E + ++E + ++
Sbjct: 896 IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEV 955
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM-NVEELNKMNLELIDKHVQK 995
S ++ + Y+ E + +E ++ + L N + K+ LI++
Sbjct: 956 SSGLK------QNYD---EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL 1006
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
Q+ + E+ N ++ + + E + + N + S + S +
Sbjct: 1007 QRVSRLE--EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQ 1064
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI-- 1113
+ E E+Q + K L + E+ Q LV++ + +++ + I + + +I
Sbjct: 1065 TISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQK 1124
Query: 1114 -ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
I+S + D+ + + E ++ L+++ +L +LQE
Sbjct: 1125 LITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEAL 1184
Query: 1173 T--KIIQLETLNTELTGHDVVNQEQ--INQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
T K I + E + + Q++ N+L+ + ++ + EN+N+ + +L+ + ++
Sbjct: 1185 TSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI 1244
Query: 1229 DQR--GFEIAELWKQHLAQREADFQKTEHE-----LRVQLSAFESKYEQLLDSVQSSTQE 1281
D + + E E F+ TE L L + + ++Q T
Sbjct: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSV 1304
Query: 1282 ETNKIVTME---QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
K E + L+ K+ L E+ + QI EIE K
Sbjct: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTV----- 1359
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+ E+ + + + + + +L+K ++++
Sbjct: 1360 -SHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE-FENVRQQLVEYEKRIEDLTYEKES 1457
EA + ++ ++ ++ ++ + H + +DE + ++ +L E +++ E++ E +
Sbjct: 1419 EAALTKIQTEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
Query: 1458 ELAILRLKMHENANHYETMQKESEI-ERVKLIEELNVKITESVS-LNKQVAELNKALEEE 1515
+ I R + E +++ + E + L ++T+S++ + QV+ NK +
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+ + L+ + +++T D + L+N +SS + K
Sbjct: 1538 LGRL----ALLQEERDKLITEMDR-SLLENQSLSSSCESLK 1573
Score = 83.8 bits (198), Expect = 5e-15
Identities = 201/1164 (17%), Positives = 465/1164 (39%), Gaps = 88/1164 (7%)
Query: 473 EDVNEIAKVQEQLKQELNDEI--KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVK 530
+D NE A Q Q+L D++ K + + +L + + D N+ V
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 466
Query: 531 SNHKLKLKQMQKTIDNFS-KVSDSNKEIVRLTEELHHLSQKVAELEEEKGN-------LQ 582
+ L++ ++N + S+ E+ L E LS ++ LE + +
Sbjct: 467 EENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSE 526
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL-----ESQKFDLVQELHILQQKY 637
+ +VD + R ++ + + +EN + K +S+L E+Q+ +L + ++
Sbjct: 527 ISIVDIANKRSSSAEESGQDV-LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRA 585
Query: 638 DEVEDKLAD---ISQLQSDQVCSEIKSVHLEE--QIDALSASKKELALVIENLKLDKEQL 692
+E + ++ D + Q++ + + V LE+ Q L +++ +E + E
Sbjct: 586 EEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ 645
Query: 693 YGTIKDLE-NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
T +++ ND + + +++ + + +++ L ++I E + + Q
Sbjct: 646 SRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQE 705
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK-Q 810
+ + E+ I N+ + ++K + + + R L + +L + + Q
Sbjct: 706 IYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQ 765
Query: 811 KAYSEYTIQEDELVNRLAVLMD--HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
E + E E RL HD ++ +Q+ + E K K ++L E ++Q+
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQ 825
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
S+ +L + ESE + ++R + S ++ ++ + QK+ EI +
Sbjct: 826 FSEQSTLIRSLQSQLQNK---ESEVLEGAERVRHISSKVEELSQA----LSQKELEITKM 878
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE--YKNNIENLNMNVE-ELNKMN 985
+ +E RD + L + E+ + VT++ + E + N E ++ VE + K
Sbjct: 879 D---QLLLEKK-RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQ 934
Query: 986 LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ-KINNAQVSYMSMVS 1044
L L+ + + ++ Q + E N++++ LKQ +E+ Q Q + +
Sbjct: 935 LNLLSRAEEAKKEQ--------VEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSK---QLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
+ E + + L N +E +QRVS+ +L + K +++ L + +++E KE K
Sbjct: 987 ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 1102 FEMNIPKTEGMI---ISSTIEPMSDDANNV--DXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
E + I + TI + ++ D V++ + +Q+++
Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKT- 1105
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV----------------NQEQINQLK 1200
Q L E+ E I +L T NT+ + D V ++ +L+
Sbjct: 1106 --NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELE 1163
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
K+ L E + L + E +S A+ ++ E ++ L Q++ D+ + + + Q
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTS-RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
E+ +QL + K+ + +Q S + +E + ++ + + +
Sbjct: 1223 SKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES 1282
Query: 1321 EILR---SEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQL 1377
+ S ED + E + + +EE QL
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342
Query: 1378 KKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENV 1437
++ ++AE L +LE S++ E+ L + DE + +
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLE--SSQLQIAGLEHLRELQPKLDELQKL 1400
Query: 1438 RQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI---ERVKLIEELNVK 1494
+ E + EKE+ L ++ ++ E + + + + E+ E + I++L V+
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVE 1460
Query: 1495 ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ E +++ E ++A ++++ + ++Q AL +++ E + N + ++ R + ++
Sbjct: 1461 LCEMKQKPEEIGEESRA-KQQIQR--KLQAALISRK-EALKENKSLQEELSLARGTIERL 1516
Query: 1555 QKHVSFASDTKQGRDEQLDNTMNK 1578
K ++ ++++ D + +
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGR 1540
Score = 53.6 bits (123), Expect = 6e-06
Identities = 103/559 (18%), Positives = 233/559 (41%), Gaps = 41/559 (7%)
Query: 168 METTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIA 227
++ ++ +E +N+ I +++ K E+ ++ + E+
Sbjct: 2529 LDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRR 2588
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++EKQ L K+IES V IS L L+ + L H++L + E+
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ-EEGTLGLYHAQLKVKEEEVHRLSAL 2647
Query: 288 XXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELEN 347
+A+ E C +K ++ G +E +L K+++ L H +R + E
Sbjct: 2648 FSSSQKRIAELEEELVCVQKEAAKKVGEIE----DKLKKELKHLHHDAGIMRNETETAEE 2703
Query: 348 KLATMG-----TESKAVS-SPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKK 401
++A + E K + + KG + GR+ +S Q S + N++ D+
Sbjct: 2704 RVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS------LQNSRDHANEELDEL 2757
Query: 402 INKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM- 460
K + A L+ + Q + L+++E +T ++ ++ L+ +QQ +
Sbjct: 2758 KRKYD-ASLKELAQLKEQGLLNRERDALLSETAFSMNST----EENSLSHLEKLNQQLLS 2812
Query: 461 EGPSLIHVGTNTED-VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEI 519
+ L+H+ + ED N++ + + N+ +D ++ + +EK + +EE +
Sbjct: 2813 KDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE--RD-HLWNELEKFRKSEE-----GKQR 2864
Query: 520 DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEK 578
AA S +++ ++K + + D KE+ L ++ ++Q++ EL K
Sbjct: 2865 SAAQ------PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLK 2918
Query: 579 GNLQLHLVDYDSGRMIESDVYKKMIEMEN-LAETRLKAISLLESQKFDLVQELHILQQKY 637
LQ + + ++++ ++ ++ + ++ L + R++ S ++ Q L + K
Sbjct: 2919 AQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKD 2978
Query: 638 DEVEDKLADISQLQSDQVCSEIKSVHLEEQID-ALSASKKELALVIENLKLDKEQLYGTI 696
++ I +L+S ++ V + Q SAS ++ +L + QL ++
Sbjct: 2979 QQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSL 3038
Query: 697 KDLENDKEDIMNKLQNYIQ 715
K++ + I N+ Q
Sbjct: 3039 KEIHQKELRIQQLNSNFSQ 3057
Score = 44.0 bits (99), Expect = 0.005
Identities = 91/497 (18%), Positives = 208/497 (41%), Gaps = 38/497 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW---KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS 268
E ++++ ++ + + ME + E + L I+S +SSL+ + E+
Sbjct: 2699 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
++ +EL Q L++ + + E+ + LE N L+K
Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSH---LEKLNQQLLSKDE 2815
Query: 329 ELLEHLNCQIRQTNKELEN---KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+LL HL+ Q+ + ++++ +A++ E + + +K K R+ A SP
Sbjct: 2816 QLL-HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQ-RSAAQPSTSP 2873
Query: 386 WSQLSSE----TLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
S + +L D D+ + E+ L+ +N+++ + + ++
Sbjct: 2874 AEVQSLKKAMSSLQNDRDRLLK--ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF 2931
Query: 442 XXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN-VK 499
++ L + L +H+ H + + ++ +++E +++EQ ++D+ + ++ ++
Sbjct: 2932 QIMQEELRQENLSWQHELHQ-----LRMEKSSWEIHE-RRMKEQYLMAISDKDQQLSHLQ 2985
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
+LI +L+S+ Q L + + L + + ++++DS KEI +
Sbjct: 2986 NLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLR--TQLNDSLKEIHQ 3043
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAI 616
+ L+ ++L EEK L + L D Y ++ + E + L+A
Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAG 3103
Query: 617 SLLESQKFDLVQELHILQQKYD--EVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
L QE + + +K D E+ + S+ Q Q+C+ + V+ LEE+ D
Sbjct: 3104 PLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQ-QQLCNTRQEVNELRKLLEEERD 3162
Query: 670 ALSASKKELALVIENLK 686
A++ L++ E ++
Sbjct: 3163 QRVAAENALSVAEEQIR 3179
>Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein.
Length = 1356
Score = 125 bits (301), Expect = 2e-27
Identities = 223/1163 (19%), Positives = 494/1163 (42%), Gaps = 85/1163 (7%)
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL--- 448
+ L D + I K+ KL+ N ++ K++++S K T D L
Sbjct: 252 DLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLK-TMMFSEDEALCVVDLLKEK 310
Query: 449 --IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK 506
+ Q L+ E +LIH + + +A V+E D K + + + EK +
Sbjct: 311 SGVIQDALKKSSKGELTTLIHQLQEKDKL--LAAVKEDAAAT-KDRCKQLTQEMMTEKER 367
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK-EIVRLTEELH 565
S +T++ D I K ++ + ++ Q+ F +V + + EI L +E
Sbjct: 368 S-NVVMTRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 426
Query: 566 HLSQKVAELE---EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
L V+ E K + +L+ + D R++ +++ +K +++ + A E
Sbjct: 427 ILRDAVSNTTNQLESKQSAELNKLRQDYARLV-NELTEKTGKLQQEEVQKKNA----EQA 481
Query: 623 KFDLVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
L +L +++++EV+ + ++ ++ Q + K V E ++ +L + + +
Sbjct: 482 ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS 541
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH 741
+ L+ QL + + N +E + ++Q+ +++N L ++++ ++ ++ A +
Sbjct: 542 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 601
Query: 742 EEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ 801
EE K+ I E+D I+ E L+ + R+ EE + +++ + L+ + +
Sbjct: 602 EELHKV---------IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQK 652
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L + E+ A E +++ + V D R++E+QL +HE ++ +IL ++
Sbjct: 653 LQALANEQAAAAHEL----EKMQQSVYVKDDKIRLLEEQL---QHEISNKMEEFKILNDQ 705
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK 921
N+ L+ S++Q+ + E+ N+ + + E +++ + LK + +T ++Q
Sbjct: 706 NKALK---SEVQKLQTLVSEQPNKDVVEQMEKC-----IQEKDEKLKTVEELLETGLIQV 757
Query: 922 KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
+ E+L T+ S ++ + L K + + + +E +L++ + + +VEEL
Sbjct: 758 ATKEEELNA-IRTENSSLTKEVQDLKAKQNDQVSFASLVE-ELKKVIHEKDGKIKSVEEL 815
Query: 982 NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
+ EL+ K K++T +Q I + + ++ + + +++ K+ Q +
Sbjct: 816 --LEAELL-KVANKEKTVQD--LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQ----N 866
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVRE-QDDQIKELKETKL 1100
++ E ++ LE E+++ K L D ++ NE L+ V+E +KE
Sbjct: 867 LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ 926
Query: 1101 TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ 1160
E+ I E +E M + + VQ+E + + + EQ
Sbjct: 927 FEELEIVLKEKGNELKRLEAMLKERES-----DLSSKTQLLQDVQDENKLFKSQI---EQ 978
Query: 1161 SAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
+ N + + +L + +E +++ LK +E +N++L E
Sbjct: 979 LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1038
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREA---DFQKTEHELRVQLSAFES-KYEQLLDSVQ 1276
+++S ++ + K+ Q EA + ++ +L ++S + Y + L +
Sbjct: 1039 MEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE 1098
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ---EKYADVINQIE----ILRSEIED 1329
+E E+V L++KL++ +E LQ EKY V+ + E L+ +E
Sbjct: 1099 KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQ 1158
Query: 1330 EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS--ILNINEENAQLKKSSXXXXXX 1387
E+ + + Q ++++ ++ I N+ E L+
Sbjct: 1159 EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME 1218
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKR 1447
V + + + EL +L+ SE ++ E + Q N+ +R + E +K
Sbjct: 1219 RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKV 1278
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
DL ++ + L +++ K+ + A T+ + S++ E + K T SVSLN+ V +
Sbjct: 1279 AGDL-HKAQQSLELIQSKIVKAAGD-TTVIENSDVSPET---ESSEKETMSVSLNQTVTQ 1333
Query: 1508 LN---KALEEEVAKTNEMQTALE 1527
L +A+ +++ K E LE
Sbjct: 1334 LQQLLQAVNQQLTKEKEHYQVLE 1356
Score = 94.7 bits (225), Expect = 2e-18
Identities = 193/1020 (18%), Positives = 440/1020 (43%), Gaps = 91/1020 (8%)
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAV-SSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
+ + + +Q +++E ++A + E+ + + S + L S++S +K++ +++L
Sbjct: 401 QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE--LNKLRQDYARLV 458
Query: 391 SET------LNQDTDKKINKNEIA-KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+E L Q+ +K N + A +L++ +Q + + + I ++
Sbjct: 459 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 518
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K +A+ H + + V + + ++ + K+ +E + V+D++E
Sbjct: 519 SK--FVAKENEVQSLHSKLTDTL-VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE 575
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVRL 560
+ ++ + QI Q + +I A + + HK+ K KQ+++T D+ + D +
Sbjct: 576 QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD---RLTSK 632
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI-SLL 619
EEL + L+ E LQ L + + E +KM + + + +++ + L
Sbjct: 633 EEELKDIQNMNFLLKAEVQKLQA-LANEQAAAAHE---LEKMQQSVYVKDDKIRLLEEQL 688
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + ++E IL + ++ ++ + L S+Q ++ EQ++ K E
Sbjct: 689 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-----VEQMEKCIQEKDEKL 743
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+E L L+ G I+ KE+ +N ++ EN LT +++ + A++ ++
Sbjct: 744 KTVEEL-LET----GLIQ--VATKEEELNAIRT---ENSSLTKEVQDLKAKQNDQVSFAS 793
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
EE K+ I E+D I+++E L ++ E+++ +D + ++
Sbjct: 794 LVEELKKV---------IHEKDGKIKSVEELLEAELLKVANKEKTV---QDLKQEIKALK 841
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
+++G+ EK + S T + EL N L + ++ L E E + K Q L
Sbjct: 842 EEIGNVQLEKAQQLS-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 900
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
EEN++L+ + ++ QH A++ + E + +L+ LE+ LK E ++ +
Sbjct: 901 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKGNELKRLEAMLK----ERESDLS 956
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEK-------YEKNIEYVTQLEAQLQEYKNNIE 972
K + ++D++ E N +S I K N + +E+ ++ +++ E ++ N ++
Sbjct: 957 SKTQLLQDVQDE-NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 1015
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+L VE K N +L +K+ + + + TE+ + + K+N K++ +++ A+ +
Sbjct: 1016 SLKDAVEHQRKKNNDLREKNWEAMEALAS--TEKMLQD--KVNKTSKERQQQVEAVELEA 1071
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
VS S L+ + L E++ +K+ + +EE+++L + ++
Sbjct: 1072 KEVLKKLFPKVS-VPSNLS-YGEWLHGFEKK----AKECMAGTSGSEEVKVL----EHKL 1121
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
KE E ++ K + +++ T + +V+ +KV E + I+
Sbjct: 1122 KEADEMHTLLQLECEKYKS-VLAETEGILQKLQRSVE-----QEENKWKVKVDESHKTIK 1175
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+ +Q EL+ ++ +E L E ++ ++ + + + ++ D
Sbjct: 1176 Q---MQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDL 1232
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
L +L S S AV Q E L K L + +TE R +++ K +Q L
Sbjct: 1233 LTELQKKLDDSYSEAVRQN--EELNLLKAQLNETLTKL-RTEQNERQKVAGDLHKAQQSL 1289
Query: 1273 DSVQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ +QS + +E S + + +KE +L + + ++ + ++ EK
Sbjct: 1290 ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1349
Score = 69.3 bits (162), Expect = 1e-10
Identities = 113/589 (19%), Positives = 246/589 (41%), Gaps = 52/589 (8%)
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
I+++ + + LL E+ A + M+ + + ++ +E+E
Sbjct: 330 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVMTRMKDRIGTLEKEHNVF 389
Query: 1068 SKQLLDSKQHNEELQIL---VREQ-DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
++ S Q +++Q+ VREQ + +I LK+ + T + S S
Sbjct: 390 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESK----QSA 445
Query: 1124 DANNV--DXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N + D K+Q+EE +Q+++ ++ + +L +LQE + ++++
Sbjct: 446 ELNKLRQDYARLVNELTEKTGKLQQEE--VQKKNA-EQAATQLKVQLQEAERRWEEVQSY 502
Query: 1182 NTELTG-HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
+ T H+ Q+ ++ +K ++ + + L T+ + ++QR ++ E +
Sbjct: 503 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ-----LEQRLMQLMES-E 556
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTME--QVT 1293
Q +E Q ++ Q A +++ +Q + + T EE +K++ + Q+
Sbjct: 557 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 616
Query: 1294 SLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR 1353
++ L + + L + +E+ D+ N +L++E++ + +L
Sbjct: 617 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL--------ANEQAAAAHELE 668
Query: 1354 TENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
QS ++ + + EE Q + S+ + +E + L+ T E +
Sbjct: 669 KMQQSVYVKDDK--IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ-TLVSEQPN 725
Query: 1414 SEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY 1473
++ ++ + Q DE ++L+E I+ T KE EL +R +
Sbjct: 726 KDVVEQMEK----CIQEKDEKLKTVEELLE-TGLIQVAT--KEEELNAIRTENSSLTKEV 778
Query: 1474 ETMQ--KESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
+ ++ + ++ L+EEL I E K V EL LE E+ K + +++ +
Sbjct: 779 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL---LEAELLKVANKEKTVQDLKQ 835
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
EI L +EI N+Q + +A I V + +G++EQ+ NTM L
Sbjct: 836 EIKALKEEIGNVQ-LEKAQQLSITSKVQELQNLLKGKEEQM-NTMKAVL 882
Score = 64.1 bits (149), Expect = 4e-09
Identities = 150/812 (18%), Positives = 331/812 (40%), Gaps = 44/812 (5%)
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
R ++ I D++ + ++K + ++ SE ++ +L + LAV D V
Sbjct: 43 REQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL 102
Query: 840 QLLEIE---HENKELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTK 895
++E E K+ +KK + +LEE + S + + + T +E+ ++K
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + ++ + +TL+V K++ E L + T+ ES KK ++K +
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQ-EALPLHQETKQESG-SGKKASSKKQKTENV 220
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+V + Y ++N + + + ++L+ K Q + Q T++ E +K N
Sbjct: 221 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL-KPDQVEGIQKSG-TKKLKTETDKEN 278
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A +K KD + + + + + +S + Q K ++ + E+ + QL
Sbjct: 279 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQL---- 333
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L V+E K+ + +LT EM K ++ + ++
Sbjct: 334 QEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVMTRMKDRIGTLEKEHNVFQNK 392
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNT-ELTGHDV 1190
Q + +F Q R ++ + A L E L++ + QLE+ + EL
Sbjct: 393 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ 452
Query: 1191 VNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+N+L K L+Q + N +L+ + A ++R E+ ++ A+ E
Sbjct: 453 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA-ERRWEEVQSYIRKRTAEHE 511
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
A Q + + + + +S + +L D++ S Q E + ME NK + + ++
Sbjct: 512 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 571
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM----- 1362
++ E+ + QI+ S+I + A +TE+ +
Sbjct: 572 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 631
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+E+ + +I N LK ++ E ++ + +KD +I +
Sbjct: 632 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQ 687
Query: 1423 YTITLTQRNDEFENVRQQ---LVEYEKRIEDLTYEKESELAILRLK--MHENANHYETMQ 1477
++ + +EF+ + Q L ++++ L E+ ++ + +++ + E +T++
Sbjct: 688 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 747
Query: 1478 KESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
+ E +++ EELN TE+ SL K+V +L ++V+ + +E + I
Sbjct: 748 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS----FASLVEELKKVIH 803
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
+ +I +++ ++ A K+ D KQ
Sbjct: 804 EKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 835
Score = 54.4 bits (125), Expect = 3e-06
Identities = 138/734 (18%), Positives = 300/734 (40%), Gaps = 69/734 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXX 199
+L D+ +++ +K + L L + + +Q+ + KD I +
Sbjct: 635 ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 694
Query: 200 XXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE--AN 257
+ K ++ K+Q + E KD +++ K I+ KD ++ ++EE
Sbjct: 695 KMEEFKILNDQNKALKSEVQKLQT--LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 752
Query: 258 KLLEAARFE-----ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE 312
L++ A E I E+S L +E+ Q L ++ + E+ +I+
Sbjct: 753 GLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 811
Query: 313 KGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR 372
L A + ++ K + ++ L +I+ +E+ N + S + + L +
Sbjct: 812 VEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK 871
Query: 373 KSGRNTASKM----------KSPW---SQLSSETLNQDTDKKINKN--------EIAKLE 411
+ NT + W Q +E+L + N + +LE
Sbjct: 872 EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELE 931
Query: 412 MVIQSLNKDLVDKEYVISEKDTXXXXXX---XXXXGKDTLI-AQL-QLEHQQHMEGPSLI 466
+V++ +L E ++ E+++ ++ L +Q+ QL+ Q + + S
Sbjct: 932 IVLKEKGNELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 991
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDV------NVKDLIEKLKSAEEQIT----QLN 516
+ ++E K L EL D +KD DL EK A E + L
Sbjct: 992 PHEELLKVISEREKEISGLWNEL-DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQ 1050
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAE-LE 575
D+++ +K + +L+ K++ K + F KVS + + E LH +K E +
Sbjct: 1051 DKVNKTSKERQQQVEAVELEAKEVLKKL--FPKVSVPSN--LSYGEWLHGFEKKAKECMA 1106
Query: 576 EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
G+ ++ ++++ ++ E+D ++++E E ++ E L + + +
Sbjct: 1107 GTSGSEEVKVLEH---KLKEADEMHTLLQLE--CEKYKSVLAETEGILQKLQRSVEQEEN 1161
Query: 636 KYD-EVEDKLADISQLQSDQVCSEIKSVHLEEQ---IDALSASKKELALVIENLKLDKEQ 691
K+ +V++ I Q+QS SE + L + I+ L ++ L + +E ++++
Sbjct: 1162 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERST 1221
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
+++L++ ++ KL + E + ++L + A+ ++E L K+ EQ++ Q
Sbjct: 1222 YVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQ-LNETLTKL-RTEQNERQKVA 1279
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME---DRRYSLERKADQLGSYLQE 808
G K Q+ +E I+S++ K +E S E + ++ +Q + LQ+
Sbjct: 1280 GDLHKAQQS---LELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQ 1336
Query: 809 KQKAYSEYTIQEDE 822
+A ++ +E E
Sbjct: 1337 LLQAVNQQLTKEKE 1350
>U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protein
protein.
Length = 3210
Score = 125 bits (301), Expect = 2e-27
Identities = 273/1350 (20%), Positives = 579/1350 (42%), Gaps = 118/1350 (8%)
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE-QXXXXXXXXXXXXXXLAKQSIEP 302
E+ +EE L E R SLE KL +++E Q L+ + E
Sbjct: 1636 ETPSAPAKGVEELESLCEVYRQ--SLE--KLEEKMESQGIMKNKEIQELEQLLSSERQEL 1691
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK-ELENKLATMGTESKAVSS 361
C K + E + +T +T +E+ L + +QT + LE ++A + + +SS
Sbjct: 1692 DCLRKQYLSENEQWQ-QKLTSVT--LEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1748
Query: 362 PSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKD 420
S G GRN + + K S+ + T D + +K+ L + I+ + +
Sbjct: 1749 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1808
Query: 421 LVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK 480
K + G+D + + GP+ + + +I
Sbjct: 1809 GAVKPTGECSGEQSPDTNYEPP-GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1867
Query: 481 VQEQLKQELNDEIKDVNV-KDLIEKLKSAEEQITQLNDEIDAANKN-MIKVKSNHKLKLK 538
+Q ++K+ N+ ++ ++V +D K++S ++ +L+ ++ M K+++
Sbjct: 1868 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA-----CI 1922
Query: 539 QMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+++K + K SD ++++ + + L Q+V E +L++H D S I +
Sbjct: 1923 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMH-ADKSSREDIGDN 1981
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
V K + +S + S+K + E L+ + V+ +KL L+ D
Sbjct: 1982 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC----LEKDNEN 2037
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLK-----LDK--EQLYGTIKDLENDKEDIMNK 709
+ V LEE++ +++ + +L ++ + LD+ E++ ++LE+ + + ++
Sbjct: 2038 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2097
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+Q E + T+ L+ +S++ +SELL H Q K+Q+ + +EN +
Sbjct: 2098 IQVAEAEVKEKTELLQTLSSD-VSELLKDKTHL-QEKLQSLEKDSQALSLTKCELENQIA 2155
Query: 770 ELSKYKSRICRLEESI-AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL----- 823
+L+K K + + ES+ A + + Y + L + L EK + + ++E+
Sbjct: 2156 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2215
Query: 824 -VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ +L V ++ D EK+ L I + KE +++N L ++ +NL+ L +++ ++
Sbjct: 2216 GIEKLRVRIEAD---EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILD 2272
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
A + AE E+ K TQ+ ++ +LK + TL +K+ + ++ E Q+ D
Sbjct: 2273 AENSK-AEVETLK--TQIEEMARSLKVFELDLVTLRSEKENLTKQIQ-EKQGQLSEL--D 2326
Query: 943 KKVLNEKYEKNIEYVTQLEAQL-QEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQS 1000
K L ++ +E Q E Q+ +E K +E L ++ELN+ L D+ + K QS
Sbjct: 2327 K--LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2384
Query: 1001 PD----YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D Q N I KL A L+ +++ + + Q++ S++ + L + +
Sbjct: 2385 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE---------SEHHADLLK--GR 2433
Query: 1057 LENMEEEMQ--RVSKQ--LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+EN+E E++ R +++ L+++ E++ L + + + L+ +L ++ ++E
Sbjct: 2434 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL--DVVTIRSEKE 2491
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
+++ ++ + + ++ + ++E+E +Q + L T+L+E
Sbjct: 2492 DLTNELQKEQERISELEIINSSFEN----ILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2547
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG 1232
++ L + Q+ L+ + QL D + L+SS++ + +
Sbjct: 2548 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE-- 2605
Query: 1233 FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
E KQ L +++ + + +++++ Q EQL+ + +Q E + EQ
Sbjct: 2606 ---VEDGKQKLEKKDEEISRLKNQIQDQ--------EQLVSKL---SQVEGEHQLWKEQN 2651
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRS---EIEDE-------KVAFXXXXXXXX 1342
L+N + E+ ++ LQ K A + + +E+L+S +E+E K++F
Sbjct: 2652 LELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMT 2711
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
++ Q ++QE+ N QL N
Sbjct: 2712 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 2771
Query: 1401 KVLELTHQLEL-KDSEIYQKTHEYTITLTQRNDEFENV-----RQQLVEYEKRIEDLTYE 1454
K L+ H+ ++ K+ ++ ++ EY + L + + + + +Q VE + E LT
Sbjct: 2772 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT-S 2830
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
KE L+ +L++ + E + + +++EEL K T+ +L K V +L K E
Sbjct: 2831 KEECLSSQKLEIDLLKSSKEELNNSLK-ATTQILEEL--KKTKMDNL-KYVNQLKKENER 2886
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
K + + + E E L E++ LQ
Sbjct: 2887 AQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2916
Score = 119 bits (287), Expect = 8e-26
Identities = 207/951 (21%), Positives = 423/951 (44%), Gaps = 82/951 (8%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE---HSKLAQELEQXXXXXXXXXXX 291
EK L KD E+K I LEE ++ + R ++ E SK L+Q
Sbjct: 2027 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 2086
Query: 292 XXXLAKQSI------EPSCEEKTEIEEKGSLEIANM----TELTKKIELLEHLNCQIRQT 341
+ + E +EKTE+ + S +++ + T L +K++ LE + + T
Sbjct: 2087 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2146
Query: 342 NKELENKLATMGTESKAVSSPSKKGSPLISRKSGR--NTASKMKSPWSQLSSETLN-QDT 398
ELEN++A + E + + S+ +S N + +++ + L T
Sbjct: 2147 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST 2206
Query: 399 DKKIN--KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
++++ + I KL + I++ K K+ I+EK K + L+ E
Sbjct: 2207 QEEVHQLRRGIEKLRVRIEADEK----KQLHIAEKLKERERENDSLKDK---VENLEREL 2259
Query: 457 QQHMEGPSLIHVGT-NTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKL-KSAEEQI 512
Q E L+ + N++ E K Q E++ + L E+ V ++ E L K +E+
Sbjct: 2260 QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2319
Query: 513 TQLN--DEIDAANKNMIKVKSNHKLKLKQMQKTIDNF--SKVSDSNKEIVRLT--EELHH 566
QL+ D++ ++ K++++ K ++++K+ KT +++ + N+ + L +E+
Sbjct: 2320 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2379
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
+++ + E+ + + ++ R+ E+D K++ ++ L E+ A LL+ + +L
Sbjct: 2380 ATEQSLDPPIEEEHQLRNSIEKLRARL-EADEKKQLCVLQQLKESEHHA-DLLKGRVENL 2437
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
+EL I + + + L+++ E+++ L+ +I+ ++ S + L L + ++
Sbjct: 2438 ERELEIARTNQEH--------AALEAENSKGEVET--LKAKIEGMTQSLRGLELDVVTIR 2487
Query: 687 LDKEQLYGTI-KDLENDKE-DIMNK-LQNYIQEN-MDLTDKLEKMSA--EKISELLAKIN 740
+KE L + K+ E E +I+N +N +QE + EK S E + L ++N
Sbjct: 2488 SEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2547
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+ Q AK Q +E +E E ++ + + + V++ L ++ +
Sbjct: 2548 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2607
Query: 801 QLGSYLQEKQKAYSEYTIQ---EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
L++K + S Q +++LV++L+ + ++ ++Q LE+ + EL++K Q+
Sbjct: 2608 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2667
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
L +N +LQ +L +Q Y L + T + + + ++ E+ L+R HE
Sbjct: 2668 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2727
Query: 918 IVQKKKEIED----LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ ++E+ L E +E K L E +N E L+ +K+ +E
Sbjct: 2728 TAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM---HKDQVEK 2784
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-------EII 1026
EE+ + L L + +K Q D +QY EI L K+E EI
Sbjct: 2785 EGKVREEIAEYQLRLHEAE-KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2843
Query: 1027 AL---NQKINNAQVSYMSMVSDY-ESKL--AQFTTKLENMEEEMQRVSKQLLDS-KQHNE 1079
L +++NN+ + ++ + ++K+ ++ +L+ E Q K L+ S KQ E
Sbjct: 2844 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2903
Query: 1080 ELQILVRE----QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
E +IL +E Q Q K+ T + +++ TE + T+E + +A+
Sbjct: 2904 EKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 2954
Score = 99.5 bits (237), Expect = 9e-20
Identities = 216/1150 (18%), Positives = 476/1150 (41%), Gaps = 117/1150 (10%)
Query: 463 PSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
PS + G+ ED+ E + + ++ L E+K + K + L A +N
Sbjct: 155 PSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA-----TMN------ 203
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
++++ + +++ + Q +KT + S S+S + +R + S ++ E+ + LQ
Sbjct: 204 HRDIARHQASSSVFSWQQEKTPSHLS--SNSQRTPIRRDFSASYFSGEL-EVTPSRSTLQ 260
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ D +S S + +++ + I+ LE + +E+ K+ E++
Sbjct: 261 IGKRDANSSFFGNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL 320
Query: 643 KL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+L A + ++ ++V ++ + + AS K AL + LK E L ++ E
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAE 379
Query: 701 NDKEDIMNKL---QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
+ + + K+ + QE + + + ++ ++ A++ E Q + A++
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQ--EKQKA 812
+ + +E+ L ++K ++CR E++ + + L R +++ + L+ +QKA
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA 499
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
E E EL N L E+ ++ ++ ++E ++ L+E N Q + +
Sbjct: 500 -REVCHLEAELKNIKQCLNQSQNFAEE--MKAKNTSQETMLRD---LQEKINQQENSLTL 553
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLE 929
++ A+ + + D ++ K + + L L + E + L+ KKKE E+L+
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+K + + +N + +TQ+E++ + ++ I +L + + I
Sbjct: 614 -----------EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE------TCLKTQQI 656
Query: 990 DKHVQKQQTQSPDYTEQYIN-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMS 1041
H ++ ++ + + ++ EI L+ +L K E+ + L QK + +
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
+ + K +Q T ++E++E ++Q +S +++D + ++L D +K K+ L
Sbjct: 717 EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS-KDASLV 775
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER-- 1154
N ++ M N+ +++ ++ +Q R
Sbjct: 776 --TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
Query: 1155 --SVLQEQSAKLNTELQECYTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
E ++N++LQ+ +++Q++ + L + ++Q + + ++ +L +
Sbjct: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
Query: 1212 NLLSTVAELRSS----------ISSAVDQRGFEIAELWK-QHLAQREADFQKTEHELRVQ 1260
+ VAE S+ ++ V+ EI EL K HL + D K L
Sbjct: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSET 950
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
LS + + ++ + +E T + T++++ + L ++ +L E +A+ I++
Sbjct: 951 LSLEKKEMSSIISLNKREIEELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDER 1007
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS-----ILNINEENA 1375
E SE+ D+ DL +Q YK QE++ +LN
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDL---SQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
+ +K+ + + E +Q + + E Q+ +T Q N + E
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 1436 --NVRQQLV-------EYEKRIEDLTYEKESELAILRLKMHENAN-HYETMQ---KESEI 1482
++Q+++ + +K + DL E E + +++ K HE N E ++ KE E
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRNSVKERES 1183
Query: 1483 ER----VKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLND 1538
ER K +L VK S N Q+ +L L + K E + E + E+ T+
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 1539 --EITNLQNM 1546
E +NLQ+M
Sbjct: 1244 DLETSNLQDM 1253
Score = 89.8 bits (213), Expect = 7e-17
Identities = 204/1121 (18%), Positives = 463/1121 (41%), Gaps = 106/1121 (9%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
E LK++ N E+++ K L ++K+ + ++ +Q + ++++ + +++ + Q +
Sbjct: 165 EDLKEKYNKEVEER--KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
KT + S S+S + +R + S ++ E+ + LQ+ D +S S
Sbjct: 223 KTPSHLS--SNSQRTPIRRDFSASYFSGEL-EVTPSRSTLQIGKRDANSSFFGNSSSPHL 279
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEI 659
+ +++ + I+ LE + +E+ K+ E++ +L A + ++ ++V ++
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL---QNYIQE 716
+ + AS K AL + LK E L ++ E+ + + K+ + QE
Sbjct: 340 RDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398
Query: 717 NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
+ + + ++ ++ A++ E Q + A++ + + +E+ L ++K
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 777 RICRLEESIAVMEDRRYSLERKADQL---GSYLQE--KQKAYSEYTIQEDELVNRLAVLM 831
++CR E++ + + L R +++ + L+ +QKA E E EL N L
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA-REVCHLEAELKNIKQCLN 517
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
E+ ++ ++ ++E ++ L+E N Q + +++ A+ + + D ++
Sbjct: 518 QSQNFAEE--MKAKNTSQETMLRD---LQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQIESAIRDKKVLNE 948
K + + L L + E + L+ KKKE E+L+ E K + +
Sbjct: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE-----------KTLFSC 621
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+N + +TQ+E++ + ++ I +L + + I H ++ ++ + + +
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLE------TCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 1009 N-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
+ EI L+ +L K E+ + L QK + + + + K +Q T ++E++
Sbjct: 676 SVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDL 735
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
E ++Q +S +++D + ++L D +K + +T N ++
Sbjct: 736 EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT---NEDHQRSLLAFDQQPA 792
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER----SVLQEQSAKLNTELQEC 1171
M N+ +++ ++ +Q R E ++N++LQ+
Sbjct: 793 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852
Query: 1172 YTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA--- 1227
+++Q++ + L + ++Q + + ++ +L + + VAE S++ +
Sbjct: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE 912
Query: 1228 -------VDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSST 1279
V+ EI EL K HL + D K L LS + + ++ +
Sbjct: 913 LQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 1280 QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXX 1339
+E T + T++++ + L ++ +L E +A+ I++ E SE+ D+
Sbjct: 970 EELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 1340 XXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE 1399
DL +Q YK QE+ N + L ++ +A
Sbjct: 1027 QRCEETGNAYEDL---SQKYKAAQEK-----NSKLECLLNECTSLCENRKNELEQLKEAF 1078
Query: 1400 AKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
AK HQ E + + + L E E V+Q L + D +SE
Sbjct: 1079 AK----EHQ-EFLTKLAFAEERNQNLML-----ELETVQQAL---RSEMTDNQNNSKSEA 1125
Query: 1460 AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
L+ ++ MQKE + + + V T+ N + + +++E ++
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Query: 1520 NEM----QTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
N+ Q LE +EI + + N ++ L+ M+R K+Q+
Sbjct: 1186 NQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE 1226
Score = 87.4 bits (207), Expect = 4e-16
Identities = 184/929 (19%), Positives = 377/929 (40%), Gaps = 74/929 (7%)
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+++ LK ++L I +LE + +++ + + +L +LEK E I E +N
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI-EKEKVLN 337
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKA 799
++T A+ + +E +L K + C+ + + E R SLE+K
Sbjct: 338 KCRDELVRT----TAQYDQASTKYTALEQKLKKLTEDLSCQRQNA----ESARCSLEQK- 388
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
++EK+K + E EL + D+ + + E ++ + + +L
Sbjct: 389 ------IKEKEKEFQE------ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
E L ++ + +K R + A S + +LR +K+ + ++
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
QK +E+ LE E + + + E KN T L LQE N EN ++ +E
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR-DLQEKINQQEN-SLTLE 554
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
K+ L + D ++KQ+ S D ++ + I +LN L + ++E AL + + Y
Sbjct: 555 ---KLKLAVAD--LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 1040 MSMVSD---YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ + + ++ L ME E + + ++ + + QI E +++++ L+
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + I ++ S ++E + ++ K E E + S
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK--EIENMCLKTSQ 727
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
L Q L +LQ +I+ + +L + + LKSK L T D+ S
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE---YESLRDLLKSKDASLVTNEDHQRSL 784
Query: 1217 VA-----ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+A + S ++ + ++G +E + L EAD Q ++ + +++ + L
Sbjct: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRL---EAD-QSPKNS-----AILQNRVDSL 835
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
S++S Q ++ E++ ++ ++ EE+L ++ + + + S+++++
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEI---EENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYK----QMQEQSILN--INEENAQLKKSSXXXX 1385
A +L+ N + ++QE N + + +L+ S
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYE 1445
++ + ++ ELT + EI ++ + L Q+++ F N + E E
Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQKSESFAN---YIDERE 1008
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQV 1505
K I +L+ + + E IL + E N YE + ++ + + K +L + E SL +
Sbjct: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK-NSKLECLLNECTSLCENR 1067
Query: 1506 AELNKALEEEVAKTN-EMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH-VSFASD 1563
+ L+E AK + E T L E L E+ +Q +R+ + Q + S A
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
Query: 1564 TKQG----RDEQLDNTMNKELLDAVPRAE 1588
KQ ++EQ N M KE+ D + E
Sbjct: 1128 LKQEIMTLKEEQ--NKMQKEVNDLLQENE 1154
Score = 83.0 bits (196), Expect = 8e-15
Identities = 168/797 (21%), Positives = 350/797 (43%), Gaps = 80/797 (10%)
Query: 233 KDEKQRLLKDIESKDVRISSLEE-----ANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++E +L + IE VRI + E+ A KL E R SL+ + LE+
Sbjct: 2207 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK--VENLERELQMSEE 2264
Query: 288 XXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
A+ S KT+IEE SL++ + +T + E E+L QI++ +L
Sbjct: 2265 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK-ENLTKQIQEKQGQL- 2322
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
++L + + K++ ++ I +S + +++ +L+ D++I K
Sbjct: 2323 SELDKLLSSFKSLLEEKEQAEIQIKEES-KTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2381
Query: 407 IAKLEMVIQSLN--KDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQL------QLEHQQ 458
L+ I+ + ++ ++K E D + A L LE +
Sbjct: 2382 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2441
Query: 459 HMEGPSLIHVGTNTE----DVNEIAKVQEQLKQELND-EIKDVNVK----DLIEKLKSAE 509
+ + H E +V + E + Q L E+ V ++ DL +L+ +
Sbjct: 2442 EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQ 2501
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
E+I++L + I+++ +N+++ K K+++K+ T + KE+ LH+ Q
Sbjct: 2502 ERISEL-EIINSSFENILQEKEQEKVQMKEKSSTA--MEMLQTQLKELNERVAALHN-DQ 2557
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+ + +E+ + Q+ ++ + ++++ L E + I +L+S L+QE
Sbjct: 2558 EACKAKEQNLSSQVECLELEKAQLLQG-----------LDEAKNNYI-VLQSSVNGLIQE 2605
Query: 630 LHILQQKYDEVEDKLADI-SQLQS-DQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
+ +QK ++ +++++ + +Q+Q +Q+ S++ V E Q+ KE L + NL +
Sbjct: 2606 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL------WKEQNLELRNLTV 2659
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNY---IQENMDLTDKLEKMS-AEKISELLAKINHEE 743
+ EQ ++ +D + LQ+ ++ ++LT K++KMS EK++++ AK E
Sbjct: 2660 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT-KMDKMSFVEKVNKMTAK-ETEL 2717
Query: 744 QSKIQTQFGIDAKIQERDLYIEN-IESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
Q ++ A++QE +N + EL I ++ + + L++ D +
Sbjct: 2718 QREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM 2777
Query: 803 GSYLQEKQ----KAYSEYTIQEDELVNR-LAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
EK+ + +EY ++ E + A+L+D ++ E +EI+ ++L K +
Sbjct: 2778 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE---VEIQTYREKLTSKEEC 2834
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT--QLRDLESNLKRITHEHQ 915
L + + + S ++ N+L KA L E + TK + L+ +R + +
Sbjct: 2835 LSSQKLEIDLLKSSKEELNNSL--KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2892
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
LI K+ E+ EI ++ + + EK + T ++ ++ E I+ L
Sbjct: 2893 LLIKSCKQLEEEKEI-----LQKELSQLQAAQEKQKTG----TVMDTKVDELTTEIKELK 2943
Query: 976 MNVEELNKMNLELIDKH 992
+EE K E +DK+
Sbjct: 2944 ETLEEKTKEADEYLDKY 2960
Score = 81.4 bits (192), Expect = 2e-14
Identities = 226/1233 (18%), Positives = 519/1233 (42%), Gaps = 133/1233 (10%)
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
++++ ++L + + K N+ +L++ ++ +L++KE V+++
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ---ELNDEIKDVN 497
T L+ + ++ E S + + K++E+ K+ EL+ + +
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
Query: 498 VKD---------LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS 548
D L ++L+ A+ L E+D ++++N + +++ + F
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
E+ R EE+ + + E+K HL ++ + + + +N
Sbjct: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL------EAELKNIKQCLNQSQNF 522
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI----KSVHL 664
AE + E+ DL ++++ + + KLA ++ L+ + CS+ + H+
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA-VADLEKQRDCSQDLLKKREHHI 581
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
E+ D LS ++KE ++ L+L K K+ E KE+ + EN L L
Sbjct: 582 EQLNDKLSKTEKESKALLSALELKK-------KEYEELKEE-KTLFSCWKSENEKL---L 630
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQ----FGIDAKIQERDLYIENIESELSKYKSRICR 780
+M +EK L +KINH E ++TQ + +++ ++ EN+ E+ + +
Sbjct: 631 TQMESEK-ENLQSKINHLETC-LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY----SEYTIQEDELVNRLAVL----MD 832
+ + L++KA+ Q++ + S+ T Q ++L ++L +L MD
Sbjct: 689 KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
Query: 833 HDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQ----HY---NALVEKAN 884
DR + L E+E+ ++L K L N++ Q SL Q H+ N + E+ +
Sbjct: 749 KDRCYQD--LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS 806
Query: 885 ----RTD--LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
R++ L +S K L++ +L+ + + +K+ E+L ++ +IE
Sbjct: 807 MPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEEL-VQIKGEIEE 865
Query: 939 AIRDKKVLNEKY-EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
+ + +++ + + + +++L+ ++N + +E K L+L++ V+ +Q
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK-ELQLLNDKVETEQ 924
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ I E+ K N LL+ +E+ L++ ++ + S++S + ++ + T +
Sbjct: 925 AE--------IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL----KETKLTFEMNIPKTEGMI 1113
++E ++++ ++ Q +E + E++ I EL K+ KL +T
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 1114 I------------SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS 1161
+S +E + ++ ++ +E +EF+ + + +E++
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERN 1096
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAEL 1220
L EL+ + T N + + +++I LK + ++ E ++LL +L
Sbjct: 1097 QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQ----KTEHELRVQLSAFESKYEQLLDSVQ 1276
+ + + + E +E + + +RE++ K + +L V+ + +S QL+
Sbjct: 1157 MKVMKTKHECQNLE-SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA 1215
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLR--NLQEKYADVINQIEILRSEIEDEKVAF 1334
+E + ++ LQ++LQ L NLQ+ + I+ ++ + E++ ++
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS- 1274
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
+L T +Q +N+ N +L+K
Sbjct: 1275 -------------GPHELSTSQNDNAHLQCSLQTTMNKLN-ELEKICEILQAEKYELVTE 1320
Query: 1395 VNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
+ND+ ++ + T ++ E+ + +E I ND+ + +LVE E E
Sbjct: 1321 LNDSRSECITATRKMA---EEVGKLLNEVKIL----NDDSGLLHGELVEDIPGGE--FGE 1371
Query: 1455 KESELAILRLKMHENANHYETM---QKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
+ +E + L + +N YE + KE ++ +L E+ +E L+ Q +++
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS-- 1429
Query: 1512 LEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+K +E+QT +++ + E + L+ + N Q
Sbjct: 1430 -----SKMSELQTYVDSLKAENLVLSTNLRNFQ 1457
Score = 77.8 bits (183), Expect = 3e-13
Identities = 164/839 (19%), Positives = 363/839 (43%), Gaps = 101/839 (12%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
I N++ + + + RL + V+EDR +RK + L L E ++ S+ +QE +L
Sbjct: 1865 IHNLQLRVKETSNENLRL---LHVIEDR----DRKVESL---LNEMKELDSKLHLQEVQL 1914
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSD-MQQHYNALV 880
+ ++ ++ +++V E++ EN +L +K + ++Q L ++ S+ +
Sbjct: 1915 MTKIEACIELEKIVG----ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA 1970
Query: 881 EKANRTDLAESEST---KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+K++R D+ ++ + ++ + D+E+ L RI E K IE + +E
Sbjct: 1971 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--------KASIEHEALYLEADLE 2022
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN--LELIDKHVQK 995
+K L + E + + LE +L + L ++ ++K L+ + + +++
Sbjct: 2023 VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKE 2082
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + ++ I A +K+K E + L+ S VS+
Sbjct: 2083 KTQELESHQSECLHCIQVAEAEVKEKTELLQTLS-----------SDVSELLKDKTHLQE 2131
Query: 1056 KLENMEEEMQRVS--KQLLDSK--QHNEELQILVREQDDQIKELKETKLTFEMNIPKT-E 1110
KL+++E++ Q +S K L+++ Q N+E ++LV+E + L E+ ++N+ K E
Sbjct: 2132 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYE-KLNVSKALE 2190
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE---FIQERSVLQEQSAKLNTE 1167
++ + + + ++++ +E+ I E+ +E+ +
Sbjct: 2191 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD 2250
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQE-QINQLKSKLEQLNTENDNLLSTVAELRS---S 1223
E + +Q+ N EL D N + ++ LK+++E++ + LRS +
Sbjct: 2251 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2310
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET 1283
++ + ++ +++EL K + + +K + E++++ ESK ++ +Q+ +E
Sbjct: 2311 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE---ESK--TAVEMLQNQLKELN 2365
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE-DEKVAFXXXXXXXX 1342
+ + Q ++ E+ L E+ + N IE LR+ +E DEK
Sbjct: 2366 EAVAAL---CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2422
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
R EN +E I N+E+A L+ + V +AK+
Sbjct: 2423 SEHHADLLKGRVENLE----RELEIARTNQEHAALEAENSKG---------EVETLKAKI 2469
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
+T L + ++ +T R+++ E++ +L + ++RI +L S IL
Sbjct: 2470 EGMTQSLRGLELDV----------VTIRSEK-EDLTNELQKEQERISELEIINSSFENIL 2518
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+ K E + KE +++++ T+ LN++VA L+ E AK +
Sbjct: 2519 QEKEQE-----KVQMKEKSSTAMEMLQ------TQLKELNERVAALHNDQEACKAKEQNL 2567
Query: 1523 QTALENQEIEIVTL---NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ +E E+E L DE N ++++S + + + V + +DE++ N+
Sbjct: 2568 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2626
Score = 72.1 bits (169), Expect = 2e-11
Identities = 141/730 (19%), Positives = 306/730 (41%), Gaps = 55/730 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
+V L I+E +L V ++ + + + +L ++I EK + +K +
Sbjct: 2279 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2338
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKD--EKQRLLKDIE-SKDVRISSLEEANKL 259
E++K + +Q + Q ++K E S D I +
Sbjct: 2339 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2398
Query: 260 LEAARFEISLEHSK---LAQELEQXXXXXXXXXXXXXXLAKQ-SIEPSCEEKTEIE---E 312
+E R + + K + Q+L++ L ++ I + +E +E
Sbjct: 2399 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2458
Query: 313 KGSLEI--ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLI 370
KG +E A + +T+ + LE IR ++L N+L + + ++
Sbjct: 2459 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENIL 2518
Query: 371 SRKSGRNTASKMKSPWSQLSSETLNQDTDKKI----NKNEIAKL-EMVIQSLNKDL-VDK 424
K K KS + +T ++ ++++ N E K E + S + L ++K
Sbjct: 2519 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2578
Query: 425 EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ-HMEGPSLIHVGTNTED----VNEIA 479
++ D + LI +++ Q+ + + + +D V++++
Sbjct: 2579 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2638
Query: 480 KVQ--EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKL 537
+V+ QL +E N E++++ V +L +K++ + + L D ++ + +++ +L+L
Sbjct: 2639 QVEGEHQLWKEQNLELRNLTV-ELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN--ELEL 2695
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+M K + KV+ + L E+H ++QK AEL+EE + L + E
Sbjct: 2696 TKMDK-MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK 2754
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
K ++ L + LK L+ D V++ ++++ E + +L + + +
Sbjct: 2755 SSKDQLKELTLENSELK--KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2812
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
K +E Q + KE L + L++D L++ KE++ N L+ Q
Sbjct: 2813 TNKQYEVEIQTYREKLTSKEECLSSQKLEIDL---------LKSSKEELNNSLKATTQIL 2863
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
+L K KM K L K N Q K++ +++E E ++ ELS+ ++
Sbjct: 2864 EEL--KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEK---EILQKELSQLQAA 2918
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR-LAVLMDHDRV 836
+ +++ VM+ K D+L + ++E ++ E T + DE +++ ++L+ H+++
Sbjct: 2919 QEK-QKTGTVMDT-------KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2970
Query: 837 VE-KQLLEIE 845
+ K++LE +
Sbjct: 2971 EKAKEMLETQ 2980
Score = 71.3 bits (167), Expect = 3e-11
Identities = 200/1146 (17%), Positives = 446/1146 (38%), Gaps = 124/1146 (10%)
Query: 58 QKCLENAALVSKRIKE----HRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE 113
Q+C++ A +++ +++ H AEL V E+ KQK E+ Q +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 114 LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIK-------EKDNALSVLQVKMK 166
+ + + + +V HL +K + N ++ K
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 167 IMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFI 226
ET + DLQEKIN+++ N T +D ++ E
Sbjct: 532 SQETMLRDLQEKINQQE------NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 227 AMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXX 286
++ + E + LL +E K L+E L + E+ KL ++E
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK----SENEKLLTQMES------ 635
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL-LEHLNCQIRQTNKEL 345
K++++ + ++ E + +E+ E+L+ +IR + L
Sbjct: 636 ---------EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
++K + T+ A +K S + + M SQL+ + + + ++ N
Sbjct: 687 DSKSVEVETQKLAYMELQQKAE--FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSN 744
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
EI + Q L+ + ++ KD +D + L + Q M
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKD------ASLVTNEDHQRSLLAFDQQPAMHHSFA 798
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+G +E ++ + + Q + +++ ++ L+ + E Q+N ++ +
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKN---SAILQNRVDSLEFSLESQKQMNSDLQKQCEE 855
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL 585
++++K + L + ++ +F V+++++ I +L E+ VAE N + L
Sbjct: 856 LVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+++ V + E++ L K+ LLE D ++EL +L + + +++
Sbjct: 914 ------QLLNDKVETEQAEIQELK----KSNHLLE----DSLKELQLLSETLSLEKKEMS 959
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
I L ++ E++ + + KE+ + K++ Q + + +++E
Sbjct: 960 SIISLNKREI----------EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREK 1009
Query: 706 IMNKLQN-YIQENMDLTDKLEKM--SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDL 762
+++L + Y QE + L + E+ + E +S+ K E+ SK ++ + E
Sbjct: 1010 SISELSDQYKQEKLILLQRCEETGNAYEDLSQKY-KAAQEKNSK------LECLLNECTS 1062
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
EN ++EL + K + E + ++ ER + + +Q SE T ++
Sbjct: 1063 LCENRKNELEQLKEAFAK--EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ L +++++ ++ E ++QK+ LL+EN+ L + + N
Sbjct: 1121 SKSEAGGL-------KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL---- 1169
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
ES + +++ ES + + Q + K+ ++ + Q+E+ +R+
Sbjct: 1170 ---------ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL-VQLEAMLRN 1219
Query: 943 KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM-NVEELNKMNLELIDKHVQKQQTQSP 1001
K++ ++ EK E L+ +LQ + ++E N+ +++ L+ + +++ P
Sbjct: 1220 KELKLQESEKEKEC---LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
N+ L L+ ++ L + Q +V++ ++ T M
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
EE V K L + K N++ +L EL E E E +S + P+
Sbjct: 1337 EE---VGKLLNEVKILNDDSGLL-------HGELVEDIPGGEFGEQPNEQHPVS--LAPL 1384
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLET 1180
+ + ++QE+ +Q E +L +Q ++++++ E T + L+
Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444
Query: 1181 LNTELT 1186
N L+
Sbjct: 1445 ENLVLS 1450
Score = 35.9 bits (79), Expect = 1.2
Identities = 27/119 (22%), Positives = 57/119 (47%), Gaps = 2/119 (1%)
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
T+ ++QE + ++ L ++ + L+ ++ QKQ TQ + + + + N
Sbjct: 14 TRTLQKIQELEGQLDKLKKEKQQ-RQFQLDSLEAAPQKQ-TQKVENEKTEGTNLKRENQR 71
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
L + E + QKI++ S V+ E +L ++E +E+E++R +L S+Q
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
>AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 125 bits (301), Expect = 2e-27
Identities = 273/1350 (20%), Positives = 579/1350 (42%), Gaps = 118/1350 (8%)
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE-QXXXXXXXXXXXXXXLAKQSIEP 302
E+ +EE L E R SLE KL +++E Q L+ + E
Sbjct: 1540 ETPSAPAKGVEELESLCEVYRQ--SLE--KLEEKMESQGIMKNKEIQELEQLLSSERQEL 1595
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK-ELENKLATMGTESKAVSS 361
C K + E + +T +T +E+ L + +QT + LE ++A + + +SS
Sbjct: 1596 DCLRKQYLSENEQWQ-QKLTSVT--LEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1652
Query: 362 PSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKD 420
S G GRN + + K S+ + T D + +K+ L + I+ + +
Sbjct: 1653 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712
Query: 421 LVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK 480
K + G+D + + GP+ + + +I
Sbjct: 1713 GAVKPTGECSGEQSPDTNYEPP-GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1771
Query: 481 VQEQLKQELNDEIKDVNV-KDLIEKLKSAEEQITQLNDEIDAANKN-MIKVKSNHKLKLK 538
+Q ++K+ N+ ++ ++V +D K++S ++ +L+ ++ M K+++
Sbjct: 1772 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA-----CI 1826
Query: 539 QMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+++K + K SD ++++ + + L Q+V E +L++H D S I +
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMH-ADKSSREDIGDN 1885
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
V K + +S + S+K + E L+ + V+ +KL L+ D
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC----LEKDNEN 1941
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLK-----LDK--EQLYGTIKDLENDKEDIMNK 709
+ V LEE++ +++ + +L ++ + LD+ E++ ++LE+ + + ++
Sbjct: 1942 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2001
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+Q E + T+ L+ +S++ +SELL H Q K+Q+ + +EN +
Sbjct: 2002 IQVAEAEVKEKTELLQTLSSD-VSELLKDKTHL-QEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 770 ELSKYKSRICRLEESI-AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL----- 823
+L+K K + + ES+ A + + Y + L + L EK + + ++E+
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 824 -VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ +L V ++ D EK+ L I + KE +++N L ++ +NL+ L +++ ++
Sbjct: 2120 GIEKLRVRIEAD---EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILD 2176
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
A + AE E+ K TQ+ ++ +LK + TL +K+ + ++ E Q+ D
Sbjct: 2177 AENSK-AEVETLK--TQIEEMARSLKVFELDLVTLRSEKENLTKQIQ-EKQGQLSEL--D 2230
Query: 943 KKVLNEKYEKNIEYVTQLEAQL-QEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQS 1000
K L ++ +E Q E Q+ +E K +E L ++ELN+ L D+ + K QS
Sbjct: 2231 K--LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2288
Query: 1001 PD----YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D Q N I KL A L+ +++ + + Q++ S++ + L + +
Sbjct: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE---------SEHHADLLK--GR 2337
Query: 1057 LENMEEEMQ--RVSKQ--LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+EN+E E++ R +++ L+++ E++ L + + + L+ +L ++ ++E
Sbjct: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL--DVVTIRSEKE 2395
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
+++ ++ + + ++ + ++E+E +Q + L T+L+E
Sbjct: 2396 NLTNELQKEQERISELEIINSSFEN----ILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG 1232
++ L + Q+ L+ + QL D + L+SS++ + +
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE-- 2509
Query: 1233 FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
E KQ L +++ + + +++++ Q EQL+ + +Q E + EQ
Sbjct: 2510 ---VEDGKQKLEKKDEEISRLKNQIQDQ--------EQLVSKL---SQVEGEHQLWKEQN 2555
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRS---EIEDE-------KVAFXXXXXXXX 1342
L+N + E+ ++ LQ K A + + +E+L+S +E+E K++F
Sbjct: 2556 LELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMT 2615
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
++ Q ++QE+ N QL N
Sbjct: 2616 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 2675
Query: 1401 KVLELTHQLEL-KDSEIYQKTHEYTITLTQRNDEFENV-----RQQLVEYEKRIEDLTYE 1454
K L+ H+ ++ K+ ++ ++ EY + L + + + + +Q VE + E LT
Sbjct: 2676 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT-S 2734
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
KE L+ +L++ + E + + +++EEL K T+ +L K V +L K E
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLK-ATTQILEEL--KKTKMDNL-KYVNQLKKENER 2790
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
K + + + E E L E++ LQ
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820
Score = 119 bits (287), Expect = 8e-26
Identities = 207/951 (21%), Positives = 423/951 (44%), Gaps = 82/951 (8%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE---HSKLAQELEQXXXXXXXXXXX 291
EK L KD E+K I LEE ++ + R ++ E SK L+Q
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
Query: 292 XXXLAKQSI------EPSCEEKTEIEEKGSLEIANM----TELTKKIELLEHLNCQIRQT 341
+ + E +EKTE+ + S +++ + T L +K++ LE + + T
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 342 NKELENKLATMGTESKAVSSPSKKGSPLISRKSGR--NTASKMKSPWSQLSSETLN-QDT 398
ELEN++A + E + + S+ +S N + +++ + L T
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST 2110
Query: 399 DKKIN--KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
++++ + I KL + I++ K K+ I+EK K + L+ E
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEK----KQLHIAEKLKERERENDSLKDK---VENLEREL 2163
Query: 457 QQHMEGPSLIHVGT-NTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKL-KSAEEQI 512
Q E L+ + N++ E K Q E++ + L E+ V ++ E L K +E+
Sbjct: 2164 QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 513 TQLN--DEIDAANKNMIKVKSNHKLKLKQMQKTIDNF--SKVSDSNKEIVRLT--EELHH 566
QL+ D++ ++ K++++ K ++++K+ KT +++ + N+ + L +E+
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
+++ + E+ + + ++ R+ E+D K++ ++ L E+ A LL+ + +L
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSIEKLRARL-EADEKKQLCVLQQLKESEHHA-DLLKGRVENL 2341
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
+EL I + + + L+++ E+++ L+ +I+ ++ S + L L + ++
Sbjct: 2342 ERELEIARTNQEH--------AALEAENSKGEVET--LKAKIEGMTQSLRGLELDVVTIR 2391
Query: 687 LDKEQLYGTI-KDLENDKE-DIMNK-LQNYIQEN-MDLTDKLEKMSA--EKISELLAKIN 740
+KE L + K+ E E +I+N +N +QE + EK S E + L ++N
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+ Q AK Q +E +E E ++ + + + V++ L ++ +
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2511
Query: 801 QLGSYLQEKQKAYSEYTIQ---EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
L++K + S Q +++LV++L+ + ++ ++Q LE+ + EL++K Q+
Sbjct: 2512 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2571
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
L +N +LQ +L +Q Y L + T + + + ++ E+ L+R HE
Sbjct: 2572 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2631
Query: 918 IVQKKKEIED----LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ ++E+ L E +E K L E +N E L+ +K+ +E
Sbjct: 2632 TAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM---HKDQVEK 2688
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-------EII 1026
EE+ + L L + +K Q D +QY EI L K+E EI
Sbjct: 2689 EGKVREEIAEYQLRLHEAE-KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747
Query: 1027 AL---NQKINNAQVSYMSMVSDY-ESKL--AQFTTKLENMEEEMQRVSKQLLDS-KQHNE 1079
L +++NN+ + ++ + ++K+ ++ +L+ E Q K L+ S KQ E
Sbjct: 2748 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
Query: 1080 ELQILVRE----QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
E +IL +E Q Q K+ T + +++ TE + T+E + +A+
Sbjct: 2808 EKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 2858
Score = 99.1 bits (236), Expect = 1e-19
Identities = 216/1150 (18%), Positives = 475/1150 (41%), Gaps = 117/1150 (10%)
Query: 463 PSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
PS + G+ ED+ E + + ++ L E+K + K + L A +N
Sbjct: 155 PSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA-----TMN------ 203
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
++++ + +++ + Q +KT + S S+S + +R + S + E+ + LQ
Sbjct: 204 HRDIARHQASSSVFSWQQEKTPSHLS--SNSQRTPIRRDFSASYFSGE-QEVTPSRSTLQ 260
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ D +S S + +++ + I+ LE + +E+ K+ E++
Sbjct: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL 320
Query: 643 KL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+L A + ++ ++V ++ + + AS K AL + LK E L ++ E
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAE 379
Query: 701 NDKEDIMNKL---QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
+ + + K+ + QE + + + ++ ++ A++ E Q + A++
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQ--EKQKA 812
+ + +E+ L ++K ++CR E++ + + L R +++ + L+ +QKA
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA 499
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
E E EL N L E+ ++ ++ ++E ++ L+E N Q + +
Sbjct: 500 -REVCHLEAELKNIKQCLNQSQNFAEE--MKAKNTSQETMLRD---LQEKINQQENSLTL 553
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLE 929
++ A+ + + D ++ K + + L L + E + L+ KKKE E+L+
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+K + + +N + +TQ+E++ + ++ I +L + + I
Sbjct: 614 -----------EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE------TCLKTQQI 656
Query: 990 DKHVQKQQTQSPDYTEQYIN-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMS 1041
H ++ ++ + + ++ EI L+ +L K E+ + L QK + +
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
+ + K +Q T ++E++E ++Q +S +++D + ++L D +K K+ L
Sbjct: 717 EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS-KDASLV 775
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER-- 1154
N ++ M N+ +++ ++ +Q R
Sbjct: 776 --TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
Query: 1155 --SVLQEQSAKLNTELQECYTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
E ++N++LQ+ +++Q++ + L + ++Q + + ++ +L +
Sbjct: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
Query: 1212 NLLSTVAELRSS----------ISSAVDQRGFEIAELWK-QHLAQREADFQKTEHELRVQ 1260
+ VAE S+ ++ V+ EI EL K HL + D K L
Sbjct: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSET 950
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
LS + + ++ + +E T + T++++ + L ++ +L E +A+ I++
Sbjct: 951 LSLEKKEMSSIISLNKREIEELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDER 1007
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS-----ILNINEENA 1375
E SE+ D+ DL +Q YK QE++ +LN
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDL---SQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
+ +K+ + + E +Q + + E Q+ +T Q N + E
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 1436 --NVRQQLV-------EYEKRIEDLTYEKESELAILRLKMHENAN-HYETMQ---KESEI 1482
++Q+++ + +K + DL E E + +++ K HE N E ++ KE E
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRNSVKERES 1183
Query: 1483 ER----VKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLND 1538
ER K +L VK S N Q+ +L L + K E + E + E+ T+
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 1539 --EITNLQNM 1546
E +NLQ+M
Sbjct: 1244 DLETSNLQDM 1253
Score = 89.4 bits (212), Expect = 9e-17
Identities = 204/1121 (18%), Positives = 462/1121 (41%), Gaps = 106/1121 (9%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
E LK++ N E+++ K L ++K+ + ++ +Q + ++++ + +++ + Q +
Sbjct: 165 EDLKEKYNKEVEER--KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
KT + S S+S + +R + S + E+ + LQ+ D +S S
Sbjct: 223 KTPSHLS--SNSQRTPIRRDFSASYFSGE-QEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEI 659
+ +++ + I+ LE + +E+ K+ E++ +L A + ++ ++V ++
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL---QNYIQE 716
+ + AS K AL + LK E L ++ E+ + + K+ + QE
Sbjct: 340 RDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398
Query: 717 NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
+ + + ++ ++ A++ E Q + A++ + + +E+ L ++K
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 777 RICRLEESIAVMEDRRYSLERKADQL---GSYLQE--KQKAYSEYTIQEDELVNRLAVLM 831
++CR E++ + + L R +++ + L+ +QKA E E EL N L
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA-REVCHLEAELKNIKQCLN 517
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
E+ ++ ++ ++E ++ L+E N Q + +++ A+ + + D ++
Sbjct: 518 QSQNFAEE--MKAKNTSQETMLRD---LQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQIESAIRDKKVLNE 948
K + + L L + E + L+ KKKE E+L+ E K + +
Sbjct: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE-----------KTLFSC 621
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+N + +TQ+E++ + ++ I +L + + I H ++ ++ + + +
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLE------TCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 1009 N-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
+ EI L+ +L K E+ + L QK + + + + K +Q T ++E++
Sbjct: 676 SVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDL 735
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
E ++Q +S +++D + ++L D +K + +T N ++
Sbjct: 736 EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT---NEDHQRSLLAFDQQPA 792
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER----SVLQEQSAKLNTELQEC 1171
M N+ +++ ++ +Q R E ++N++LQ+
Sbjct: 793 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852
Query: 1172 YTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA--- 1227
+++Q++ + L + ++Q + + ++ +L + + VAE S++ +
Sbjct: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE 912
Query: 1228 -------VDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSST 1279
V+ EI EL K HL + D K L LS + + ++ +
Sbjct: 913 LQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 1280 QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXX 1339
+E T + T++++ + L ++ +L E +A+ I++ E SE+ D+
Sbjct: 970 EELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 1340 XXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE 1399
DL +Q YK QE+ N + L ++ +A
Sbjct: 1027 QRCEETGNAYEDL---SQKYKAAQEK-----NSKLECLLNECTSLCENRKNELEQLKEAF 1078
Query: 1400 AKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
AK HQ E + + + L E E V+Q L + D +SE
Sbjct: 1079 AK----EHQ-EFLTKLAFAEERNQNLML-----ELETVQQAL---RSEMTDNQNNSKSEA 1125
Query: 1460 AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
L+ ++ MQKE + + + V T+ N + + +++E ++
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Query: 1520 NEM----QTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
N+ Q LE +EI + + N ++ L+ M+R K+Q+
Sbjct: 1186 NQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE 1226
Score = 87.4 bits (207), Expect = 4e-16
Identities = 184/929 (19%), Positives = 377/929 (40%), Gaps = 74/929 (7%)
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+++ LK ++L I +LE + +++ + + +L +LEK E I E +N
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI-EKEKVLN 337
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKA 799
++T A+ + +E +L K + C+ + + E R SLE+K
Sbjct: 338 KCRDELVRT----TAQYDQASTKYTALEQKLKKLTEDLSCQRQNA----ESARCSLEQK- 388
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
++EK+K + E EL + D+ + + E ++ + + +L
Sbjct: 389 ------IKEKEKEFQE------ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
E L ++ + +K R + A S + +LR +K+ + ++
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
QK +E+ LE E + + + E KN T L LQE N EN ++ +E
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR-DLQEKINQQEN-SLTLE 554
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
K+ L + D ++KQ+ S D ++ + I +LN L + ++E AL + + Y
Sbjct: 555 ---KLKLAVAD--LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 1040 MSMVSD---YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ + + ++ L ME E + + ++ + + QI E +++++ L+
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + I ++ S ++E + ++ K E E + S
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK--EIENMCLKTSQ 727
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
L Q L +LQ +I+ + +L + + LKSK L T D+ S
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE---YESLRDLLKSKDASLVTNEDHQRSL 784
Query: 1217 VA-----ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+A + S ++ + ++G +E + L EAD Q ++ + +++ + L
Sbjct: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRL---EAD-QSPKNS-----AILQNRVDSL 835
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
S++S Q ++ E++ ++ ++ EE+L ++ + + + S+++++
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEI---EENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYK----QMQEQSILN--INEENAQLKKSSXXXX 1385
A +L+ N + ++QE N + + +L+ S
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYE 1445
++ + ++ ELT + EI ++ + L Q+++ F N + E E
Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQKSESFAN---YIDERE 1008
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQV 1505
K I +L+ + + E IL + E N YE + ++ + + K +L + E SL +
Sbjct: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK-NSKLECLLNECTSLCENR 1067
Query: 1506 AELNKALEEEVAKTN-EMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH-VSFASD 1563
+ L+E AK + E T L E L E+ +Q +R+ + Q + S A
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
Query: 1564 TKQG----RDEQLDNTMNKELLDAVPRAE 1588
KQ ++EQ N M KE+ D + E
Sbjct: 1128 LKQEIMTLKEEQ--NKMQKEVNDLLQENE 1154
Score = 81.4 bits (192), Expect = 2e-14
Identities = 226/1233 (18%), Positives = 519/1233 (42%), Gaps = 133/1233 (10%)
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
++++ ++L + + K N+ +L++ ++ +L++KE V+++
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ---ELNDEIKDVN 497
T L+ + ++ E S + + K++E+ K+ EL+ + +
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
Query: 498 VKD---------LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS 548
D L ++L+ A+ L E+D ++++N + +++ + F
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
E+ R EE+ + + E+K HL ++ + + + +N
Sbjct: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL------EAELKNIKQCLNQSQNF 522
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI----KSVHL 664
AE + E+ DL ++++ + + KLA ++ L+ + CS+ + H+
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA-VADLEKQRDCSQDLLKKREHHI 581
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
E+ D LS ++KE ++ L+L K K+ E KE+ + EN L L
Sbjct: 582 EQLNDKLSKTEKESKALLSALELKK-------KEYEELKEE-KTLFSCWKSENEKL---L 630
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQ----FGIDAKIQERDLYIENIESELSKYKSRICR 780
+M +EK L +KINH E ++TQ + +++ ++ EN+ E+ + +
Sbjct: 631 TQMESEK-ENLQSKINHLETC-LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY----SEYTIQEDELVNRLAVL----MD 832
+ + L++KA+ Q++ + S+ T Q ++L ++L +L MD
Sbjct: 689 KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
Query: 833 HDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQ----HY---NALVEKAN 884
DR + L E+E+ ++L K L N++ Q SL Q H+ N + E+ +
Sbjct: 749 KDRCYQD--LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS 806
Query: 885 ----RTD--LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
R++ L +S K L++ +L+ + + +K+ E+L ++ +IE
Sbjct: 807 MPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEEL-VQIKGEIEE 865
Query: 939 AIRDKKVLNEKY-EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
+ + +++ + + + +++L+ ++N + +E K L+L++ V+ +Q
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK-ELQLLNDKVETEQ 924
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ I E+ K N LL+ +E+ L++ ++ + S++S + ++ + T +
Sbjct: 925 AE--------IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL----KETKLTFEMNIPKTEGMI 1113
++E ++++ ++ Q +E + E++ I EL K+ KL +T
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 1114 I------------SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS 1161
+S +E + ++ ++ +E +EF+ + + +E++
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERN 1096
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAEL 1220
L EL+ + T N + + +++I LK + ++ E ++LL +L
Sbjct: 1097 QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQ----KTEHELRVQLSAFESKYEQLLDSVQ 1276
+ + + + E +E + + +RE++ K + +L V+ + +S QL+
Sbjct: 1157 MKVMKTKHECQNLE-SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA 1215
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLR--NLQEKYADVINQIEILRSEIEDEKVAF 1334
+E + ++ LQ++LQ L NLQ+ + I+ ++ + E++ ++
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS- 1274
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
+L T +Q +N+ N +L+K
Sbjct: 1275 -------------GPHELSTSQNDNAHLQCSLQTTMNKLN-ELEKICEILQAEKYELVTE 1320
Query: 1395 VNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
+ND+ ++ + T ++ E+ + +E I ND+ + +LVE E E
Sbjct: 1321 LNDSRSECITATRKMA---EEVGKLLNEVKIL----NDDSGLLHGELVEDIPGGE--FGE 1371
Query: 1455 KESELAILRLKMHENANHYETM---QKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
+ +E + L + +N YE + KE ++ +L E+ +E L+ Q +++
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS-- 1429
Query: 1512 LEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+K +E+QT +++ + E + L+ + N Q
Sbjct: 1430 -----SKMSELQTYVDSLKAENLVLSTNLRNFQ 1457
Score = 81.0 bits (191), Expect = 3e-14
Identities = 167/797 (20%), Positives = 350/797 (43%), Gaps = 80/797 (10%)
Query: 233 KDEKQRLLKDIESKDVRISSLEE-----ANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++E +L + IE VRI + E+ A KL E R SL+ + LE+
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK--VENLERELQMSEE 2168
Query: 288 XXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
A+ S KT+IEE SL++ + +T + E E+L QI++ +L
Sbjct: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK-ENLTKQIQEKQGQL- 2226
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
++L + + K++ ++ I +S + +++ +L+ D++I K
Sbjct: 2227 SELDKLLSSFKSLLEEKEQAEIQIKEES-KTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 407 IAKLEMVIQSLN--KDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQL------QLEHQQ 458
L+ I+ + ++ ++K E D + A L LE +
Sbjct: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
Query: 459 HMEGPSLIHVGTNTE----DVNEIAKVQEQLKQELND-EIKDVNVK----DLIEKLKSAE 509
+ + H E +V + E + Q L E+ V ++ +L +L+ +
Sbjct: 2346 EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ 2405
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
E+I++L + I+++ +N+++ K K+++K+ T + KE+ LH+ Q
Sbjct: 2406 ERISEL-EIINSSFENILQEKEQEKVQMKEKSSTA--MEMLQTQLKELNERVAALHN-DQ 2461
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+ + +E+ + Q+ ++ + ++++ L E + I +L+S L+QE
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQG-----------LDEAKNNYI-VLQSSVNGLIQE 2509
Query: 630 LHILQQKYDEVEDKLADI-SQLQS-DQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
+ +QK ++ +++++ + +Q+Q +Q+ S++ V E Q+ KE L + NL +
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL------WKEQNLELRNLTV 2563
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNY---IQENMDLTDKLEKMS-AEKISELLAKINHEE 743
+ EQ ++ +D + LQ+ ++ ++LT K++KMS EK++++ AK E
Sbjct: 2564 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT-KMDKMSFVEKVNKMTAK-ETEL 2621
Query: 744 QSKIQTQFGIDAKIQERDLYIEN-IESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
Q ++ A++QE +N + EL I ++ + + L++ D +
Sbjct: 2622 QREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM 2681
Query: 803 GSYLQEKQ----KAYSEYTIQEDELVNR-LAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
EK+ + +EY ++ E + A+L+D ++ E +EI+ ++L K +
Sbjct: 2682 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE---VEIQTYREKLTSKEEC 2738
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT--QLRDLESNLKRITHEHQ 915
L + + + S ++ N+L KA L E + TK + L+ +R + +
Sbjct: 2739 LSSQKLEIDLLKSSKEELNNSL--KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
LI K+ E+ EI ++ + + EK + T ++ ++ E I+ L
Sbjct: 2797 LLIKSCKQLEEEKEI-----LQKELSQLQAAQEKQKTG----TVMDTKVDELTTEIKELK 2847
Query: 976 MNVEELNKMNLELIDKH 992
+EE K E +DK+
Sbjct: 2848 ETLEEKTKEADEYLDKY 2864
Score = 79.8 bits (188), Expect = 7e-14
Identities = 165/839 (19%), Positives = 363/839 (43%), Gaps = 101/839 (12%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
I N++ + + + RL + V+EDR +RK + L L E ++ S+ +QE +L
Sbjct: 1769 IHNLQLRVKETSNENLRL---LHVIEDR----DRKVESL---LNEMKELDSKLHLQEVQL 1818
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSD-MQQHYNALV 880
+ ++ ++ +++V E++ EN +L +K + ++Q L ++ S+ +
Sbjct: 1819 MTKIEACIELEKIVG----ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA 1874
Query: 881 EKANRTDLAESEST---KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+K++R D+ ++ + ++ + D+E+ L RI E K IE + +E
Sbjct: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--------KASIEHEALYLEADLE 1926
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN--LELIDKHVQK 995
+K L + E + + LE +L + L ++ ++K L+ + + +++
Sbjct: 1927 VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKE 1986
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + ++ I A +K+K E + L+ S VS+
Sbjct: 1987 KTQELESHQSECLHCIQVAEAEVKEKTELLQTLS-----------SDVSELLKDKTHLQE 2035
Query: 1056 KLENMEEEMQRVS--KQLLDSK--QHNEELQILVREQDDQIKELKETKLTFEMNIPKT-E 1110
KL+++E++ Q +S K L+++ Q N+E ++LV+E + L E+ ++N+ K E
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYE-KLNVSKALE 2094
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE---FIQERSVLQEQSAKLNTE 1167
++ + + + ++++ +E+ I E+ +E+ +
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD 2154
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQE-QINQLKSKLEQLNTENDNLLSTVAELRS---S 1223
E + +Q+ N EL D N + ++ LK+++E++ + LRS +
Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET 1283
++ + ++ +++EL K + + +K + E++++ ESK ++ +Q+ +E
Sbjct: 2215 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE---ESK--TAVEMLQNQLKELN 2269
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE-DEKVAFXXXXXXXX 1342
+ + Q ++ E+ L E+ + N IE LR+ +E DEK
Sbjct: 2270 EAVAAL---CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
R EN +E I N+E+A L+ + V +AK+
Sbjct: 2327 SEHHADLLKGRVENLE----RELEIARTNQEHAALEAENSKG---------EVETLKAKI 2373
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
+T L + ++ +T R+++ EN+ +L + ++RI +L S IL
Sbjct: 2374 EGMTQSLRGLELDV----------VTIRSEK-ENLTNELQKEQERISELEIINSSFENIL 2422
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+ K E + KE +++++ T+ LN++VA L+ E AK +
Sbjct: 2423 QEKEQE-----KVQMKEKSSTAMEMLQ------TQLKELNERVAALHNDQEACKAKEQNL 2471
Query: 1523 QTALENQEIEIVTL---NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ +E E+E L DE N ++++S + + + V + +DE++ N+
Sbjct: 2472 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Score = 74.1 bits (174), Expect = 4e-12
Identities = 260/1535 (16%), Positives = 588/1535 (38%), Gaps = 159/1535 (10%)
Query: 58 QKCLENAALVSKRIKE----HRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE 113
Q+C++ A +++ +++ H AEL V E+ KQK E+ Q +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 114 LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIK-------EKDNALSVLQVKMK 166
+ + + + +V HL +K + N ++ K
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 167 IMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFI 226
ET + DLQEKIN+++ N T +D ++ E
Sbjct: 532 SQETMLRDLQEKINQQE------NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 227 AMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXX 286
++ + E + LL +E K L+E L + E+ KL ++E
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK----SENEKLLTQMES------ 635
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL-LEHLNCQIRQTNKEL 345
K++++ + ++ E + +E+ E+L+ +IR + L
Sbjct: 636 ---------EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
++K + T+ A +K S + + M SQL+ + + + ++ N
Sbjct: 687 DSKSVEVETQKLAYMELQQKAE--FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSN 744
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
EI + Q L+ + ++ KD +D + L + Q M
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKD------ASLVTNEDHQRSLLAFDQQPAMHHSFA 798
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+G +E ++ + + Q + +++ ++ L+ + E Q+N ++ +
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKN---SAILQNRVDSLEFSLESQKQMNSDLQKQCEE 855
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL 585
++++K + L + ++ +F V+++++ I +L E+ VAE N + L
Sbjct: 856 LVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+++ V + E++ L K+ LLE D ++EL +L + + +++
Sbjct: 914 ------QLLNDKVETEQAEIQELK----KSNHLLE----DSLKELQLLSETLSLEKKEMS 959
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
I L ++ E++ + + KE+ + K++ Q + + +++E
Sbjct: 960 SIISLNKREI----------EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREK 1009
Query: 706 IMNKLQN-YIQENMDLTDKLEKM--SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDL 762
+++L + Y QE + L + E+ + E +S+ K E+ SK ++ + E
Sbjct: 1010 SISELSDQYKQEKLILLQRCEETGNAYEDLSQKY-KAAQEKNSK------LECLLNECTS 1062
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
EN ++EL + K + E + ++ ER + + +Q SE T ++
Sbjct: 1063 LCENRKNELEQLKEAFAK--EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ L +++++ ++ E ++QK+ LL+EN+ L + + N
Sbjct: 1121 SKSEAGGL-------KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL---- 1169
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
ES + +++ ES + + Q + K+ ++ + Q+E+ +R+
Sbjct: 1170 ---------ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL-VQLEAMLRN 1219
Query: 943 KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM-NVEELNKMNLELIDKHVQKQQTQSP 1001
K++ ++ EK E L+ +LQ + ++E N+ +++ L+ + +++ P
Sbjct: 1220 KELKLQESEKEKEC---LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
N+ L L+ ++ L + Q +V++ ++ T M
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
EE V K L + K N++ +L EL E E E +S + P+
Sbjct: 1337 EE---VGKLLNEVKILNDDSGLL-------HGELVEDIPGGEFGEQPNEQHPVS--LAPL 1384
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLET 1180
+ + ++QE+ +Q E +L +Q ++++++ E T + L+
Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444
Query: 1181 LNTELTGH------DVVNQEQINQLKSKLEQLNTE---NDNLLSTVAE------------ 1219
N L+ + D+V + Q+ + + L++ + + LS++ +
Sbjct: 1445 ENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTG 1504
Query: 1220 ---LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
L S++ AV + E++ L + ++T + ES E S++
Sbjct: 1505 DMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLE 1564
Query: 1277 SSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFX 1335
++ E+ I+ +++ L+ L + + L L+++Y Q + + + E +
Sbjct: 1565 KLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKL 1624
Query: 1336 XXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
R + Q + +S+L I+ E+A ++
Sbjct: 1625 AAEKKQTEQLSLELEVARLQLQGL-DLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLT---QRNDEFENVRQQLVEYEKRIEDLT 1452
+ V HQ+ KD++ IT T + E + YE ED T
Sbjct: 1684 RTPKHDV----HQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
++ L + + + +I ++L + E++ L + + ++ +
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQL--RVKETSNENLRLLHVIEDRDRKV 1797
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
E + + E+ + L QE++++T + L+ +V
Sbjct: 1798 ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832
Score = 71.3 bits (167), Expect = 3e-11
Identities = 141/730 (19%), Positives = 305/730 (41%), Gaps = 55/730 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
+V L I+E +L V ++ + + + +L ++I EK + +K +
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKD--EKQRLLKDIE-SKDVRISSLEEANKL 259
E++K + +Q + Q ++K E S D I +
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302
Query: 260 LEAARFEISLEHSK---LAQELEQXXXXXXXXXXXXXXLAKQ-SIEPSCEEKTEIE---E 312
+E R + + K + Q+L++ L ++ I + +E +E
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2362
Query: 313 KGSLEI--ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLI 370
KG +E A + +T+ + LE IR + L N+L + + ++
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 371 SRKSGRNTASKMKSPWSQLSSETLNQDTDKKI----NKNEIAKL-EMVIQSLNKDL-VDK 424
K K KS + +T ++ ++++ N E K E + S + L ++K
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 425 EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ-HMEGPSLIHVGTNTED----VNEIA 479
++ D + LI +++ Q+ + + + +D V++++
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542
Query: 480 KVQ--EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKL 537
+V+ QL +E N E++++ V +L +K++ + + L D ++ + +++ +L+L
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTV-ELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN--ELEL 2599
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+M K + KV+ + L E+H ++QK AEL+EE + L + E
Sbjct: 2600 TKMDK-MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK 2658
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
K ++ L + LK L+ D V++ ++++ E + +L + + +
Sbjct: 2659 SSKDQLKELTLENSELK--KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2716
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
K +E Q + KE L + L++D L++ KE++ N L+ Q
Sbjct: 2717 TNKQYEVEIQTYREKLTSKEECLSSQKLEIDL---------LKSSKEELNNSLKATTQIL 2767
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
+L K KM K L K N Q K++ +++E E ++ ELS+ ++
Sbjct: 2768 EEL--KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEK---EILQKELSQLQAA 2822
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR-LAVLMDHDRV 836
+ +++ VM+ K D+L + ++E ++ E T + DE +++ ++L+ H+++
Sbjct: 2823 QEK-QKTGTVMDT-------KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
Query: 837 VE-KQLLEIE 845
+ K++LE +
Sbjct: 2875 EKAKEMLETQ 2884
Score = 37.9 bits (84), Expect = 0.30
Identities = 90/601 (14%), Positives = 229/601 (38%), Gaps = 14/601 (2%)
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
T+ ++QE + ++ L ++ + L+ ++ +QKQ+ + + + N + + N
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQ-RQFQLDSLEAALQKQKQKVENEKTEGTN-LKRENQR 71
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L + E + QKI++ S V+ E +L ++E +E+E++R +L S+Q
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
+ + + + +++ T LT ++ + ++ ++
Sbjct: 132 AQSADVSLNPCNTP-QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI---IQLETLNTELTGHDVVNQE 1194
+ + ++ + Q S+ + + ++ + + Q + + + ++
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQ 250
Query: 1195 QINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
++ +S L Q+ + N S+ + SS +DQ + EL + + + E Q E
Sbjct: 251 EVTPSRSTL-QIGKRDAN--SSFFD-NSSSPHLLDQLKAQNQEL-RNKINELELRLQGHE 305
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYA 1314
E++ Q++ F+ QL + ++E +++ + L++K
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365
Query: 1315 DVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
+ + R E + + + Q+ Q Q + +E
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL 425
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEF 1434
Q K E + E +L + + +Q + L + +E
Sbjct: 426 QQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL-CRAEQAFQASQIKENELRRSMEEM 484
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVK 1494
+ L + ++ E+EL ++ ++++ N E M K + ++ +L K
Sbjct: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM-KAKNTSQETMLRDLQEK 543
Query: 1495 ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
I + + + + +L A+ + + + Q L+ +E I LND+++ + +A S +
Sbjct: 544 INQQEN-SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602
Query: 1555 Q 1555
+
Sbjct: 603 E 603
>AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 125 bits (301), Expect = 2e-27
Identities = 273/1350 (20%), Positives = 579/1350 (42%), Gaps = 118/1350 (8%)
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE-QXXXXXXXXXXXXXXLAKQSIEP 302
E+ +EE L E R SLE KL +++E Q L+ + E
Sbjct: 1540 ETPSAPAKGVEELESLCEVYRQ--SLE--KLEEKMESQGIMKNKEIQELEQLLSSERQEL 1595
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK-ELENKLATMGTESKAVSS 361
C K + E + +T +T +E+ L + +QT + LE ++A + + +SS
Sbjct: 1596 DCLRKQYLSENEQWQ-QKLTSVT--LEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1652
Query: 362 PSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKD 420
S G GRN + + K S+ + T D + +K+ L + I+ + +
Sbjct: 1653 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712
Query: 421 LVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK 480
K + G+D + + GP+ + + +I
Sbjct: 1713 GAVKPTGECSGEQSPDTNYEPP-GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1771
Query: 481 VQEQLKQELNDEIKDVNV-KDLIEKLKSAEEQITQLNDEIDAANKN-MIKVKSNHKLKLK 538
+Q ++K+ N+ ++ ++V +D K++S ++ +L+ ++ M K+++
Sbjct: 1772 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA-----CI 1826
Query: 539 QMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+++K + K SD ++++ + + L Q+V E +L++H D S I +
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMH-ADKSSREDIGDN 1885
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
V K + +S + S+K + E L+ + V+ +KL L+ D
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC----LEKDNEN 1941
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLK-----LDK--EQLYGTIKDLENDKEDIMNK 709
+ V LEE++ +++ + +L ++ + LD+ E++ ++LE+ + + ++
Sbjct: 1942 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2001
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+Q E + T+ L+ +S++ +SELL H Q K+Q+ + +EN +
Sbjct: 2002 IQVAEAEVKEKTELLQTLSSD-VSELLKDKTHL-QEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 770 ELSKYKSRICRLEESI-AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL----- 823
+L+K K + + ES+ A + + Y + L + L EK + + ++E+
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 824 -VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ +L V ++ D EK+ L I + KE +++N L ++ +NL+ L +++ ++
Sbjct: 2120 GIEKLRVRIEAD---EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILD 2176
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
A + AE E+ K TQ+ ++ +LK + TL +K+ + ++ E Q+ D
Sbjct: 2177 AENSK-AEVETLK--TQIEEMARSLKVFELDLVTLRSEKENLTKQIQ-EKQGQLSEL--D 2230
Query: 943 KKVLNEKYEKNIEYVTQLEAQL-QEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQS 1000
K L ++ +E Q E Q+ +E K +E L ++ELN+ L D+ + K QS
Sbjct: 2231 K--LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2288
Query: 1001 PD----YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D Q N I KL A L+ +++ + + Q++ S++ + L + +
Sbjct: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE---------SEHHADLLK--GR 2337
Query: 1057 LENMEEEMQ--RVSKQ--LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+EN+E E++ R +++ L+++ E++ L + + + L+ +L ++ ++E
Sbjct: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL--DVVTIRSEKE 2395
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
+++ ++ + + ++ + ++E+E +Q + L T+L+E
Sbjct: 2396 NLTNELQKEQERISELEIINSSFEN----ILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG 1232
++ L + Q+ L+ + QL D + L+SS++ + +
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE-- 2509
Query: 1233 FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
E KQ L +++ + + +++++ Q EQL+ + +Q E + EQ
Sbjct: 2510 ---VEDGKQKLEKKDEEISRLKNQIQDQ--------EQLVSKL---SQVEGEHQLWKEQN 2555
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRS---EIEDE-------KVAFXXXXXXXX 1342
L+N + E+ ++ LQ K A + + +E+L+S +E+E K++F
Sbjct: 2556 LELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMT 2615
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
++ Q ++QE+ N QL N
Sbjct: 2616 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 2675
Query: 1401 KVLELTHQLEL-KDSEIYQKTHEYTITLTQRNDEFENV-----RQQLVEYEKRIEDLTYE 1454
K L+ H+ ++ K+ ++ ++ EY + L + + + + +Q VE + E LT
Sbjct: 2676 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT-S 2734
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
KE L+ +L++ + E + + +++EEL K T+ +L K V +L K E
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLK-ATTQILEEL--KKTKMDNL-KYVNQLKKENER 2790
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
K + + + E E L E++ LQ
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820
Score = 119 bits (287), Expect = 8e-26
Identities = 207/951 (21%), Positives = 423/951 (44%), Gaps = 82/951 (8%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE---HSKLAQELEQXXXXXXXXXXX 291
EK L KD E+K I LEE ++ + R ++ E SK L+Q
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
Query: 292 XXXLAKQSI------EPSCEEKTEIEEKGSLEIANM----TELTKKIELLEHLNCQIRQT 341
+ + E +EKTE+ + S +++ + T L +K++ LE + + T
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 342 NKELENKLATMGTESKAVSSPSKKGSPLISRKSGR--NTASKMKSPWSQLSSETLN-QDT 398
ELEN++A + E + + S+ +S N + +++ + L T
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST 2110
Query: 399 DKKIN--KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
++++ + I KL + I++ K K+ I+EK K + L+ E
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEK----KQLHIAEKLKERERENDSLKDK---VENLEREL 2163
Query: 457 QQHMEGPSLIHVGT-NTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKL-KSAEEQI 512
Q E L+ + N++ E K Q E++ + L E+ V ++ E L K +E+
Sbjct: 2164 QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 513 TQLN--DEIDAANKNMIKVKSNHKLKLKQMQKTIDNF--SKVSDSNKEIVRLT--EELHH 566
QL+ D++ ++ K++++ K ++++K+ KT +++ + N+ + L +E+
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
+++ + E+ + + ++ R+ E+D K++ ++ L E+ A LL+ + +L
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSIEKLRARL-EADEKKQLCVLQQLKESEHHA-DLLKGRVENL 2341
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
+EL I + + + L+++ E+++ L+ +I+ ++ S + L L + ++
Sbjct: 2342 ERELEIARTNQEH--------AALEAENSKGEVET--LKAKIEGMTQSLRGLELDVVTIR 2391
Query: 687 LDKEQLYGTI-KDLENDKE-DIMNK-LQNYIQEN-MDLTDKLEKMSA--EKISELLAKIN 740
+KE L + K+ E E +I+N +N +QE + EK S E + L ++N
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2451
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+ Q AK Q +E +E E ++ + + + V++ L ++ +
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2511
Query: 801 QLGSYLQEKQKAYSEYTIQ---EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
L++K + S Q +++LV++L+ + ++ ++Q LE+ + EL++K Q+
Sbjct: 2512 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2571
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
L +N +LQ +L +Q Y L + T + + + ++ E+ L+R HE
Sbjct: 2572 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2631
Query: 918 IVQKKKEIED----LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ ++E+ L E +E K L E +N E L+ +K+ +E
Sbjct: 2632 TAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM---HKDQVEK 2688
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-------EII 1026
EE+ + L L + +K Q D +QY EI L K+E EI
Sbjct: 2689 EGKVREEIAEYQLRLHEAE-KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747
Query: 1027 AL---NQKINNAQVSYMSMVSDY-ESKL--AQFTTKLENMEEEMQRVSKQLLDS-KQHNE 1079
L +++NN+ + ++ + ++K+ ++ +L+ E Q K L+ S KQ E
Sbjct: 2748 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
Query: 1080 ELQILVRE----QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
E +IL +E Q Q K+ T + +++ TE + T+E + +A+
Sbjct: 2808 EKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 2858
Score = 99.1 bits (236), Expect = 1e-19
Identities = 216/1150 (18%), Positives = 475/1150 (41%), Gaps = 117/1150 (10%)
Query: 463 PSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
PS + G+ ED+ E + + ++ L E+K + K + L A +N
Sbjct: 155 PSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA-----TMN------ 203
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
++++ + +++ + Q +KT + S S+S + +R + S + E+ + LQ
Sbjct: 204 HRDIARHQASSSVFSWQQEKTPSHLS--SNSQRTPIRRDFSASYFSGE-QEVTPSRSTLQ 260
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ D +S S + +++ + I+ LE + +E+ K+ E++
Sbjct: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL 320
Query: 643 KL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+L A + ++ ++V ++ + + AS K AL + LK E L ++ E
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAE 379
Query: 701 NDKEDIMNKL---QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
+ + + K+ + QE + + + ++ ++ A++ E Q + A++
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQ--EKQKA 812
+ + +E+ L ++K ++CR E++ + + L R +++ + L+ +QKA
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA 499
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
E E EL N L E+ ++ ++ ++E ++ L+E N Q + +
Sbjct: 500 -REVCHLEAELKNIKQCLNQSQNFAEE--MKAKNTSQETMLRD---LQEKINQQENSLTL 553
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLE 929
++ A+ + + D ++ K + + L L + E + L+ KKKE E+L+
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+K + + +N + +TQ+E++ + ++ I +L + + I
Sbjct: 614 -----------EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE------TCLKTQQI 656
Query: 990 DKHVQKQQTQSPDYTEQYIN-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMS 1041
H ++ ++ + + ++ EI L+ +L K E+ + L QK + +
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
+ + K +Q T ++E++E ++Q +S +++D + ++L D +K K+ L
Sbjct: 717 EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS-KDASLV 775
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER-- 1154
N ++ M N+ +++ ++ +Q R
Sbjct: 776 --TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
Query: 1155 --SVLQEQSAKLNTELQECYTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
E ++N++LQ+ +++Q++ + L + ++Q + + ++ +L +
Sbjct: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
Query: 1212 NLLSTVAELRSS----------ISSAVDQRGFEIAELWK-QHLAQREADFQKTEHELRVQ 1260
+ VAE S+ ++ V+ EI EL K HL + D K L
Sbjct: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSET 950
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
LS + + ++ + +E T + T++++ + L ++ +L E +A+ I++
Sbjct: 951 LSLEKKEMSSIISLNKREIEELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDER 1007
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS-----ILNINEENA 1375
E SE+ D+ DL +Q YK QE++ +LN
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDL---SQKYKAAQEKNSKLECLLNECTSLC 1064
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
+ +K+ + + E +Q + + E Q+ +T Q N + E
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 1436 --NVRQQLV-------EYEKRIEDLTYEKESELAILRLKMHENAN-HYETMQ---KESEI 1482
++Q+++ + +K + DL E E + +++ K HE N E ++ KE E
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRNSVKERES 1183
Query: 1483 ER----VKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLND 1538
ER K +L VK S N Q+ +L L + K E + E + E+ T+
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 1539 --EITNLQNM 1546
E +NLQ+M
Sbjct: 1244 DLETSNLQDM 1253
Score = 89.4 bits (212), Expect = 9e-17
Identities = 204/1121 (18%), Positives = 462/1121 (41%), Gaps = 106/1121 (9%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
E LK++ N E+++ K L ++K+ + ++ +Q + ++++ + +++ + Q +
Sbjct: 165 EDLKEKYNKEVEER--KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
KT + S S+S + +R + S + E+ + LQ+ D +S S
Sbjct: 223 KTPSHLS--SNSQRTPIRRDFSASYFSGE-QEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEI 659
+ +++ + I+ LE + +E+ K+ E++ +L A + ++ ++V ++
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL---QNYIQE 716
+ + AS K AL + LK E L ++ E+ + + K+ + QE
Sbjct: 340 RDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398
Query: 717 NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
+ + + ++ ++ A++ E Q + A++ + + +E+ L ++K
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 777 RICRLEESIAVMEDRRYSLERKADQL---GSYLQE--KQKAYSEYTIQEDELVNRLAVLM 831
++CR E++ + + L R +++ + L+ +QKA E E EL N L
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA-REVCHLEAELKNIKQCLN 517
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
E+ ++ ++ ++E ++ L+E N Q + +++ A+ + + D ++
Sbjct: 518 QSQNFAEE--MKAKNTSQETMLRD---LQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQIESAIRDKKVLNE 948
K + + L L + E + L+ KKKE E+L+ E K + +
Sbjct: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE-----------KTLFSC 621
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+N + +TQ+E++ + ++ I +L + + I H ++ ++ + + +
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLE------TCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 1009 N-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
+ EI L+ +L K E+ + L QK + + + + K +Q T ++E++
Sbjct: 676 SVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDL 735
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
E ++Q +S +++D + ++L D +K + +T N ++
Sbjct: 736 EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT---NEDHQRSLLAFDQQPA 792
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER----SVLQEQSAKLNTELQEC 1171
M N+ +++ ++ +Q R E ++N++LQ+
Sbjct: 793 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852
Query: 1172 YTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA--- 1227
+++Q++ + L + ++Q + + ++ +L + + VAE S++ +
Sbjct: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE 912
Query: 1228 -------VDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSST 1279
V+ EI EL K HL + D K L LS + + ++ +
Sbjct: 913 LQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 1280 QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXX 1339
+E T + T++++ + L ++ +L E +A+ I++ E SE+ D+
Sbjct: 970 EELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 1340 XXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE 1399
DL +Q YK QE+ N + L ++ +A
Sbjct: 1027 QRCEETGNAYEDL---SQKYKAAQEK-----NSKLECLLNECTSLCENRKNELEQLKEAF 1078
Query: 1400 AKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
AK HQ E + + + L E E V+Q L + D +SE
Sbjct: 1079 AK----EHQ-EFLTKLAFAEERNQNLML-----ELETVQQAL---RSEMTDNQNNSKSEA 1125
Query: 1460 AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
L+ ++ MQKE + + + V T+ N + + +++E ++
Sbjct: 1126 GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Query: 1520 NEM----QTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
N+ Q LE +EI + + N ++ L+ M+R K+Q+
Sbjct: 1186 NQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE 1226
Score = 87.4 bits (207), Expect = 4e-16
Identities = 184/929 (19%), Positives = 377/929 (40%), Gaps = 74/929 (7%)
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+++ LK ++L I +LE + +++ + + +L +LEK E I E +N
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI-EKEKVLN 337
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKA 799
++T A+ + +E +L K + C+ + + E R SLE+K
Sbjct: 338 KCRDELVRT----TAQYDQASTKYTALEQKLKKLTEDLSCQRQNA----ESARCSLEQK- 388
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
++EK+K + E EL + D+ + + E ++ + + +L
Sbjct: 389 ------IKEKEKEFQE------ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
E L ++ + +K R + A S + +LR +K+ + ++
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
QK +E+ LE E + + + E KN T L LQE N EN ++ +E
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR-DLQEKINQQEN-SLTLE 554
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
K+ L + D ++KQ+ S D ++ + I +LN L + ++E AL + + Y
Sbjct: 555 ---KLKLAVAD--LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 1040 MSMVSD---YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ + + ++ L ME E + + ++ + + QI E +++++ L+
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + I ++ S ++E + ++ K E E + S
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK--EIENMCLKTSQ 727
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
L Q L +LQ +I+ + +L + + LKSK L T D+ S
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE---YESLRDLLKSKDASLVTNEDHQRSL 784
Query: 1217 VA-----ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+A + S ++ + ++G +E + L EAD Q ++ + +++ + L
Sbjct: 785 LAFDQQPAMHHSFANIIGEQGSMPSERSECRL---EAD-QSPKNS-----AILQNRVDSL 835
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
S++S Q ++ E++ ++ ++ EE+L ++ + + + S+++++
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEI---EENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYK----QMQEQSILN--INEENAQLKKSSXXXX 1385
A +L+ N + ++QE N + + +L+ S
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYE 1445
++ + ++ ELT + EI ++ + L Q+++ F N + E E
Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQKSESFAN---YIDERE 1008
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQV 1505
K I +L+ + + E IL + E N YE + ++ + + K +L + E SL +
Sbjct: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK-NSKLECLLNECTSLCENR 1067
Query: 1506 AELNKALEEEVAKTN-EMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH-VSFASD 1563
+ L+E AK + E T L E L E+ +Q +R+ + Q + S A
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
Query: 1564 TKQG----RDEQLDNTMNKELLDAVPRAE 1588
KQ ++EQ N M KE+ D + E
Sbjct: 1128 LKQEIMTLKEEQ--NKMQKEVNDLLQENE 1154
Score = 81.4 bits (192), Expect = 2e-14
Identities = 226/1233 (18%), Positives = 519/1233 (42%), Gaps = 133/1233 (10%)
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
++++ ++L + + K N+ +L++ ++ +L++KE V+++
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ---ELNDEIKDVN 497
T L+ + ++ E S + + K++E+ K+ EL+ + +
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
Query: 498 VKD---------LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS 548
D L ++L+ A+ L E+D ++++N + +++ + F
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
E+ R EE+ + + E+K HL ++ + + + +N
Sbjct: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL------EAELKNIKQCLNQSQNF 522
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI----KSVHL 664
AE + E+ DL ++++ + + KLA ++ L+ + CS+ + H+
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA-VADLEKQRDCSQDLLKKREHHI 581
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
E+ D LS ++KE ++ L+L K K+ E KE+ + EN L L
Sbjct: 582 EQLNDKLSKTEKESKALLSALELKK-------KEYEELKEE-KTLFSCWKSENEKL---L 630
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQ----FGIDAKIQERDLYIENIESELSKYKSRICR 780
+M +EK L +KINH E ++TQ + +++ ++ EN+ E+ + +
Sbjct: 631 TQMESEK-ENLQSKINHLETC-LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY----SEYTIQEDELVNRLAVL----MD 832
+ + L++KA+ Q++ + S+ T Q ++L ++L +L MD
Sbjct: 689 KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
Query: 833 HDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQ----HY---NALVEKAN 884
DR + L E+E+ ++L K L N++ Q SL Q H+ N + E+ +
Sbjct: 749 KDRCYQD--LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS 806
Query: 885 ----RTD--LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
R++ L +S K L++ +L+ + + +K+ E+L ++ +IE
Sbjct: 807 MPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEEL-VQIKGEIEE 865
Query: 939 AIRDKKVLNEKY-EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
+ + +++ + + + +++L+ ++N + +E K L+L++ V+ +Q
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK-ELQLLNDKVETEQ 924
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ I E+ K N LL+ +E+ L++ ++ + S++S + ++ + T +
Sbjct: 925 AE--------IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL----KETKLTFEMNIPKTEGMI 1113
++E ++++ ++ Q +E + E++ I EL K+ KL +T
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 1114 I------------SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS 1161
+S +E + ++ ++ +E +EF+ + + +E++
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERN 1096
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAEL 1220
L EL+ + T N + + +++I LK + ++ E ++LL +L
Sbjct: 1097 QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQ----KTEHELRVQLSAFESKYEQLLDSVQ 1276
+ + + + E +E + + +RE++ K + +L V+ + +S QL+
Sbjct: 1157 MKVMKTKHECQNLE-SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA 1215
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLR--NLQEKYADVINQIEILRSEIEDEKVAF 1334
+E + ++ LQ++LQ L NLQ+ + I+ ++ + E++ ++
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS- 1274
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
+L T +Q +N+ N +L+K
Sbjct: 1275 -------------GPHELSTSQNDNAHLQCSLQTTMNKLN-ELEKICEILQAEKYELVTE 1320
Query: 1395 VNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
+ND+ ++ + T ++ E+ + +E I ND+ + +LVE E E
Sbjct: 1321 LNDSRSECITATRKMA---EEVGKLLNEVKIL----NDDSGLLHGELVEDIPGGE--FGE 1371
Query: 1455 KESELAILRLKMHENANHYETM---QKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
+ +E + L + +N YE + KE ++ +L E+ +E L+ Q +++
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS-- 1429
Query: 1512 LEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+K +E+QT +++ + E + L+ + N Q
Sbjct: 1430 -----SKMSELQTYVDSLKAENLVLSTNLRNFQ 1457
Score = 81.0 bits (191), Expect = 3e-14
Identities = 167/797 (20%), Positives = 350/797 (43%), Gaps = 80/797 (10%)
Query: 233 KDEKQRLLKDIESKDVRISSLEE-----ANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++E +L + IE VRI + E+ A KL E R SL+ + LE+
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK--VENLERELQMSEE 2168
Query: 288 XXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
A+ S KT+IEE SL++ + +T + E E+L QI++ +L
Sbjct: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK-ENLTKQIQEKQGQL- 2226
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
++L + + K++ ++ I +S + +++ +L+ D++I K
Sbjct: 2227 SELDKLLSSFKSLLEEKEQAEIQIKEES-KTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 407 IAKLEMVIQSLN--KDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQL------QLEHQQ 458
L+ I+ + ++ ++K E D + A L LE +
Sbjct: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
Query: 459 HMEGPSLIHVGTNTE----DVNEIAKVQEQLKQELND-EIKDVNVK----DLIEKLKSAE 509
+ + H E +V + E + Q L E+ V ++ +L +L+ +
Sbjct: 2346 EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ 2405
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
E+I++L + I+++ +N+++ K K+++K+ T + KE+ LH+ Q
Sbjct: 2406 ERISEL-EIINSSFENILQEKEQEKVQMKEKSSTA--MEMLQTQLKELNERVAALHN-DQ 2461
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+ + +E+ + Q+ ++ + ++++ L E + I +L+S L+QE
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQG-----------LDEAKNNYI-VLQSSVNGLIQE 2509
Query: 630 LHILQQKYDEVEDKLADI-SQLQS-DQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
+ +QK ++ +++++ + +Q+Q +Q+ S++ V E Q+ KE L + NL +
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL------WKEQNLELRNLTV 2563
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNY---IQENMDLTDKLEKMS-AEKISELLAKINHEE 743
+ EQ ++ +D + LQ+ ++ ++LT K++KMS EK++++ AK E
Sbjct: 2564 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT-KMDKMSFVEKVNKMTAK-ETEL 2621
Query: 744 QSKIQTQFGIDAKIQERDLYIEN-IESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
Q ++ A++QE +N + EL I ++ + + L++ D +
Sbjct: 2622 QREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM 2681
Query: 803 GSYLQEKQ----KAYSEYTIQEDELVNR-LAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
EK+ + +EY ++ E + A+L+D ++ E +EI+ ++L K +
Sbjct: 2682 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE---VEIQTYREKLTSKEEC 2738
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT--QLRDLESNLKRITHEHQ 915
L + + + S ++ N+L KA L E + TK + L+ +R + +
Sbjct: 2739 LSSQKLEIDLLKSSKEELNNSL--KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
LI K+ E+ EI ++ + + EK + T ++ ++ E I+ L
Sbjct: 2797 LLIKSCKQLEEEKEI-----LQKELSQLQAAQEKQKTG----TVMDTKVDELTTEIKELK 2847
Query: 976 MNVEELNKMNLELIDKH 992
+EE K E +DK+
Sbjct: 2848 ETLEEKTKEADEYLDKY 2864
Score = 79.8 bits (188), Expect = 7e-14
Identities = 165/839 (19%), Positives = 363/839 (43%), Gaps = 101/839 (12%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
I N++ + + + RL + V+EDR +RK + L L E ++ S+ +QE +L
Sbjct: 1769 IHNLQLRVKETSNENLRL---LHVIEDR----DRKVESL---LNEMKELDSKLHLQEVQL 1818
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSD-MQQHYNALV 880
+ ++ ++ +++V E++ EN +L +K + ++Q L ++ S+ +
Sbjct: 1819 MTKIEACIELEKIVG----ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA 1874
Query: 881 EKANRTDLAESEST---KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+K++R D+ ++ + ++ + D+E+ L RI E K IE + +E
Sbjct: 1875 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--------KASIEHEALYLEADLE 1926
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN--LELIDKHVQK 995
+K L + E + + LE +L + L ++ ++K L+ + + +++
Sbjct: 1927 VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKE 1986
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + ++ I A +K+K E + L+ S VS+
Sbjct: 1987 KTQELESHQSECLHCIQVAEAEVKEKTELLQTLS-----------SDVSELLKDKTHLQE 2035
Query: 1056 KLENMEEEMQRVS--KQLLDSK--QHNEELQILVREQDDQIKELKETKLTFEMNIPKT-E 1110
KL+++E++ Q +S K L+++ Q N+E ++LV+E + L E+ ++N+ K E
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYE-KLNVSKALE 2094
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE---FIQERSVLQEQSAKLNTE 1167
++ + + + ++++ +E+ I E+ +E+ +
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD 2154
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQE-QINQLKSKLEQLNTENDNLLSTVAELRS---S 1223
E + +Q+ N EL D N + ++ LK+++E++ + LRS +
Sbjct: 2155 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET 1283
++ + ++ +++EL K + + +K + E++++ ESK ++ +Q+ +E
Sbjct: 2215 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE---ESK--TAVEMLQNQLKELN 2269
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE-DEKVAFXXXXXXXX 1342
+ + Q ++ E+ L E+ + N IE LR+ +E DEK
Sbjct: 2270 EAVAAL---CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
R EN +E I N+E+A L+ + V +AK+
Sbjct: 2327 SEHHADLLKGRVENLE----RELEIARTNQEHAALEAENSKG---------EVETLKAKI 2373
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
+T L + ++ +T R+++ EN+ +L + ++RI +L S IL
Sbjct: 2374 EGMTQSLRGLELDV----------VTIRSEK-ENLTNELQKEQERISELEIINSSFENIL 2422
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+ K E + KE +++++ T+ LN++VA L+ E AK +
Sbjct: 2423 QEKEQE-----KVQMKEKSSTAMEMLQ------TQLKELNERVAALHNDQEACKAKEQNL 2471
Query: 1523 QTALENQEIEIVTL---NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ +E E+E L DE N ++++S + + + V + +DE++ N+
Sbjct: 2472 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Score = 74.1 bits (174), Expect = 4e-12
Identities = 260/1535 (16%), Positives = 588/1535 (38%), Gaps = 159/1535 (10%)
Query: 58 QKCLENAALVSKRIKE----HRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE 113
Q+C++ A +++ +++ H AEL V E+ KQK E+ Q +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 114 LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIK-------EKDNALSVLQVKMK 166
+ + + + +V HL +K + N ++ K
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 167 IMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFI 226
ET + DLQEKIN+++ N T +D ++ E
Sbjct: 532 SQETMLRDLQEKINQQE------NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 227 AMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXX 286
++ + E + LL +E K L+E L + E+ KL ++E
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK----SENEKLLTQMES------ 635
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL-LEHLNCQIRQTNKEL 345
K++++ + ++ E + +E+ E+L+ +IR + L
Sbjct: 636 ---------EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
++K + T+ A +K S + + M SQL+ + + + ++ N
Sbjct: 687 DSKSVEVETQKLAYMELQQKAE--FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSN 744
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
EI + Q L+ + ++ KD +D + L + Q M
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKD------ASLVTNEDHQRSLLAFDQQPAMHHSFA 798
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+G +E ++ + + Q + +++ ++ L+ + E Q+N ++ +
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKN---SAILQNRVDSLEFSLESQKQMNSDLQKQCEE 855
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL 585
++++K + L + ++ +F V+++++ I +L E+ VAE N + L
Sbjct: 856 LVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+++ V + E++ L K+ LLE D ++EL +L + + +++
Sbjct: 914 ------QLLNDKVETEQAEIQELK----KSNHLLE----DSLKELQLLSETLSLEKKEMS 959
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
I L ++ E++ + + KE+ + K++ Q + + +++E
Sbjct: 960 SIISLNKREI----------EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREK 1009
Query: 706 IMNKLQN-YIQENMDLTDKLEKM--SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDL 762
+++L + Y QE + L + E+ + E +S+ K E+ SK ++ + E
Sbjct: 1010 SISELSDQYKQEKLILLQRCEETGNAYEDLSQKY-KAAQEKNSK------LECLLNECTS 1062
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
EN ++EL + K + E + ++ ER + + +Q SE T ++
Sbjct: 1063 LCENRKNELEQLKEAFAK--EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ L +++++ ++ E ++QK+ LL+EN+ L + + N
Sbjct: 1121 SKSEAGGL-------KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL---- 1169
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
ES + +++ ES + + Q + K+ ++ + Q+E+ +R+
Sbjct: 1170 ---------ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL-VQLEAMLRN 1219
Query: 943 KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM-NVEELNKMNLELIDKHVQKQQTQSP 1001
K++ ++ EK E L+ +LQ + ++E N+ +++ L+ + +++ P
Sbjct: 1220 KELKLQESEKEKEC---LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
N+ L L+ ++ L + Q +V++ ++ T M
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
EE V K L + K N++ +L EL E E E +S + P+
Sbjct: 1337 EE---VGKLLNEVKILNDDSGLL-------HGELVEDIPGGEFGEQPNEQHPVS--LAPL 1384
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLET 1180
+ + ++QE+ +Q E +L +Q ++++++ E T + L+
Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444
Query: 1181 LNTELTGH------DVVNQEQINQLKSKLEQLNTE---NDNLLSTVAE------------ 1219
N L+ + D+V + Q+ + + L++ + + LS++ +
Sbjct: 1445 ENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTG 1504
Query: 1220 ---LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
L S++ AV + E++ L + ++T + ES E S++
Sbjct: 1505 DMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLE 1564
Query: 1277 SSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFX 1335
++ E+ I+ +++ L+ L + + L L+++Y Q + + + E +
Sbjct: 1565 KLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKL 1624
Query: 1336 XXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
R + Q + +S+L I+ E+A ++
Sbjct: 1625 AAEKKQTEQLSLELEVARLQLQGL-DLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLT---QRNDEFENVRQQLVEYEKRIEDLT 1452
+ V HQ+ KD++ IT T + E + YE ED T
Sbjct: 1684 RTPKHDV----HQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
++ L + + + +I ++L + E++ L + + ++ +
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQL--RVKETSNENLRLLHVIEDRDRKV 1797
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
E + + E+ + L QE++++T + L+ +V
Sbjct: 1798 ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832
Score = 71.3 bits (167), Expect = 3e-11
Identities = 141/730 (19%), Positives = 305/730 (41%), Gaps = 55/730 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
+V L I+E +L V ++ + + + +L ++I EK + +K +
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKD--EKQRLLKDIE-SKDVRISSLEEANKL 259
E++K + +Q + Q ++K E S D I +
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302
Query: 260 LEAARFEISLEHSK---LAQELEQXXXXXXXXXXXXXXLAKQ-SIEPSCEEKTEIE---E 312
+E R + + K + Q+L++ L ++ I + +E +E
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2362
Query: 313 KGSLEI--ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLI 370
KG +E A + +T+ + LE IR + L N+L + + ++
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 371 SRKSGRNTASKMKSPWSQLSSETLNQDTDKKI----NKNEIAKL-EMVIQSLNKDL-VDK 424
K K KS + +T ++ ++++ N E K E + S + L ++K
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 425 EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ-HMEGPSLIHVGTNTED----VNEIA 479
++ D + LI +++ Q+ + + + +D V++++
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542
Query: 480 KVQ--EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKL 537
+V+ QL +E N E++++ V +L +K++ + + L D ++ + +++ +L+L
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTV-ELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN--ELEL 2599
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+M K + KV+ + L E+H ++QK AEL+EE + L + E
Sbjct: 2600 TKMDK-MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK 2658
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
K ++ L + LK L+ D V++ ++++ E + +L + + +
Sbjct: 2659 SSKDQLKELTLENSELK--KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2716
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
K +E Q + KE L + L++D L++ KE++ N L+ Q
Sbjct: 2717 TNKQYEVEIQTYREKLTSKEECLSSQKLEIDL---------LKSSKEELNNSLKATTQIL 2767
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
+L K KM K L K N Q K++ +++E E ++ ELS+ ++
Sbjct: 2768 EEL--KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEK---EILQKELSQLQAA 2822
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR-LAVLMDHDRV 836
+ +++ VM+ K D+L + ++E ++ E T + DE +++ ++L+ H+++
Sbjct: 2823 QEK-QKTGTVMDT-------KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
Query: 837 VE-KQLLEIE 845
+ K++LE +
Sbjct: 2875 EKAKEMLETQ 2884
Score = 37.9 bits (84), Expect = 0.30
Identities = 90/601 (14%), Positives = 229/601 (38%), Gaps = 14/601 (2%)
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
T+ ++QE + ++ L ++ + L+ ++ +QKQ+ + + + N + + N
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQ-RQFQLDSLEAALQKQKQKVENEKTEGTN-LKRENQR 71
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L + E + QKI++ S V+ E +L ++E +E+E++R +L S+Q
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
+ + + + +++ T LT ++ + ++ ++
Sbjct: 132 AQSADVSLNPCNTP-QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI---IQLETLNTELTGHDVVNQE 1194
+ + ++ + Q S+ + + ++ + + Q + + + ++
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQ 250
Query: 1195 QINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
++ +S L Q+ + N S+ + SS +DQ + EL + + + E Q E
Sbjct: 251 EVTPSRSTL-QIGKRDAN--SSFFD-NSSSPHLLDQLKAQNQEL-RNKINELELRLQGHE 305
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYA 1314
E++ Q++ F+ QL + ++E +++ + L++K
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365
Query: 1315 DVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
+ + R E + + + Q+ Q Q + +E
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL 425
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEF 1434
Q K E + E +L + + +Q + L + +E
Sbjct: 426 QQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL-CRAEQAFQASQIKENELRRSMEEM 484
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVK 1494
+ L + ++ E+EL ++ ++++ N E M K + ++ +L K
Sbjct: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM-KAKNTSQETMLRDLQEK 543
Query: 1495 ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
I + + + + +L A+ + + + Q L+ +E I LND+++ + +A S +
Sbjct: 544 INQQEN-SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602
Query: 1555 Q 1555
+
Sbjct: 603 E 603
>U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein.
Length = 3113
Score = 124 bits (300), Expect = 2e-27
Identities = 273/1350 (20%), Positives = 579/1350 (42%), Gaps = 118/1350 (8%)
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE-QXXXXXXXXXXXXXXLAKQSIEP 302
E+ +EE L E R SLE KL +++E Q L+ + E
Sbjct: 1539 ETPSAPAKGVEELESLCEVYRQ--SLE--KLEEKMESQGIMKNKEIQELEQLLSSERQEL 1594
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK-ELENKLATMGTESKAVSS 361
C K + E + +T +T +E+ L + +QT + LE ++A + + +SS
Sbjct: 1595 DCLRKQYLSENEQWQ-QKLTSVT--LEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1651
Query: 362 PSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKD 420
S G GRN + + K S+ + T D + +K+ L + I+ + +
Sbjct: 1652 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1711
Query: 421 LVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAK 480
K + G+D + + GP+ + + +I
Sbjct: 1712 GALKPTGECSGEQSPDTNYEPP-GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1770
Query: 481 VQEQLKQELNDEIKDVNV-KDLIEKLKSAEEQITQLNDEIDAANKN-MIKVKSNHKLKLK 538
+Q ++K+ N+ ++ ++V +D K++S ++ +L+ ++ M K+++
Sbjct: 1771 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA-----CI 1825
Query: 539 QMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+++K + K SD ++++ + + L Q+V E +L++H D S I +
Sbjct: 1826 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMH-ADKSSREDIGDN 1884
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
V K + +S + S+K + E L+ + V+ +KL L+ D
Sbjct: 1885 VAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC----LEKDNEN 1940
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLK-----LDK--EQLYGTIKDLENDKEDIMNK 709
+ V LEE++ +++ + +L ++ + LD+ E++ ++LE+ + + ++
Sbjct: 1941 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2000
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+Q E + T+ L+ +S++ +SELL H Q K+Q+ + +EN +
Sbjct: 2001 IQVAEAEVKEKTELLQTLSSD-VSELLKDKTHL-QEKLQSLEKDSQALSLTKCELENQIA 2058
Query: 770 ELSKYKSRICRLEESI-AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL----- 823
+L+K K + + ES+ A + + Y + L + L EK + + ++E+
Sbjct: 2059 QLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2118
Query: 824 -VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ +L V ++ D EK+ L I + KE +++N L ++ +NL+ L +++ ++
Sbjct: 2119 GIEKLRVRIEAD---EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILD 2175
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
A + AE E+ K TQ+ ++ +LK + TL +K+ + ++ E Q+ D
Sbjct: 2176 AENSK-AEVETLK--TQIEEMARSLKVFELDLVTLRSEKENLTKQIQ-EKQGQLSEL--D 2229
Query: 943 KKVLNEKYEKNIEYVTQLEAQL-QEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQS 1000
K L ++ +E Q E Q+ +E K +E L ++ELN+ L D+ + K QS
Sbjct: 2230 K--LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2287
Query: 1001 PD----YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D Q N I KL A L+ +++ + + Q++ S++ + L + +
Sbjct: 2288 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE---------SEHHADLLK--GR 2336
Query: 1057 LENMEEEMQ--RVSKQ--LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+EN+E E++ R +++ L+++ E++ L + + + L+ +L ++ ++E
Sbjct: 2337 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL--DVVTIRSEKE 2394
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
+++ ++ + + ++ + ++E+E +Q + L T+L+E
Sbjct: 2395 NLTNELQKEQERISELEIINSSFEN----ILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2450
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG 1232
++ L + Q+ L+ + QL D + L+SS++ + +
Sbjct: 2451 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE-- 2508
Query: 1233 FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
E KQ L +++ + + +++++ Q EQL+ + +Q E + EQ
Sbjct: 2509 ---VEDGKQKLEKKDEEISRLKNQIQDQ--------EQLVSKL---SQVEGEHQLWKEQN 2554
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRS---EIEDE-------KVAFXXXXXXXX 1342
L+N + E+ ++ LQ K A + + +E+L+S +E+E K++F
Sbjct: 2555 LELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMT 2614
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
++ Q ++QE+ N QL N
Sbjct: 2615 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 2674
Query: 1401 KVLELTHQLEL-KDSEIYQKTHEYTITLTQRNDEFENV-----RQQLVEYEKRIEDLTYE 1454
K L+ H+ ++ K+ ++ ++ EY + L + + + + +Q VE + E LT
Sbjct: 2675 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT-S 2733
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
KE L+ +L++ + E + + +++EEL K T+ +L K V +L K E
Sbjct: 2734 KEECLSSQKLEIDLLKSSKEELNNSLK-ATTQILEEL--KKTKMDNL-KYVNQLKKENER 2789
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
K + + + E E L E++ LQ
Sbjct: 2790 AQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2819
Score = 119 bits (287), Expect = 8e-26
Identities = 207/951 (21%), Positives = 423/951 (44%), Gaps = 82/951 (8%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE---HSKLAQELEQXXXXXXXXXXX 291
EK L KD E+K I LEE ++ + R ++ E SK L+Q
Sbjct: 1930 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1989
Query: 292 XXXLAKQSI------EPSCEEKTEIEEKGSLEIANM----TELTKKIELLEHLNCQIRQT 341
+ + E +EKTE+ + S +++ + T L +K++ LE + + T
Sbjct: 1990 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2049
Query: 342 NKELENKLATMGTESKAVSSPSKKGSPLISRKSGR--NTASKMKSPWSQLSSETLN-QDT 398
ELEN++A + E + + S+ +S N + +++ + L T
Sbjct: 2050 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST 2109
Query: 399 DKKIN--KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
++++ + I KL + I++ K K+ I+EK K + L+ E
Sbjct: 2110 QEEVHQLRRGIEKLRVRIEADEK----KQLHIAEKLKERERENDSLKDK---VENLEREL 2162
Query: 457 QQHMEGPSLIHVGT-NTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKL-KSAEEQI 512
Q E L+ + N++ E K Q E++ + L E+ V ++ E L K +E+
Sbjct: 2163 QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2222
Query: 513 TQLN--DEIDAANKNMIKVKSNHKLKLKQMQKTIDNF--SKVSDSNKEIVRLT--EELHH 566
QL+ D++ ++ K++++ K ++++K+ KT +++ + N+ + L +E+
Sbjct: 2223 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2282
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
+++ + E+ + + ++ R+ E+D K++ ++ L E+ A LL+ + +L
Sbjct: 2283 ATEQSLDPPIEEEHQLRNSIEKLRARL-EADEKKQLCVLQQLKESEHHA-DLLKGRVENL 2340
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
+EL I + + + L+++ E+++ L+ +I+ ++ S + L L + ++
Sbjct: 2341 ERELEIARTNQEH--------AALEAENSKGEVET--LKAKIEGMTQSLRGLELDVVTIR 2390
Query: 687 LDKEQLYGTI-KDLENDKE-DIMNK-LQNYIQEN-MDLTDKLEKMSA--EKISELLAKIN 740
+KE L + K+ E E +I+N +N +QE + EK S E + L ++N
Sbjct: 2391 SEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN 2450
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+ Q AK Q +E +E E ++ + + + V++ L ++ +
Sbjct: 2451 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2510
Query: 801 QLGSYLQEKQKAYSEYTIQ---EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
L++K + S Q +++LV++L+ + ++ ++Q LE+ + EL++K Q+
Sbjct: 2511 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2570
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
L +N +LQ +L +Q Y L + T + + + ++ E+ L+R HE
Sbjct: 2571 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2630
Query: 918 IVQKKKEIED----LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ ++E+ L E +E K L E +N E L+ +K+ +E
Sbjct: 2631 TAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM---HKDQVEK 2687
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-------EII 1026
EE+ + L L + +K Q D +QY EI L K+E EI
Sbjct: 2688 EGKVREEIAEYQLRLHEAE-KKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2746
Query: 1027 AL---NQKINNAQVSYMSMVSDY-ESKL--AQFTTKLENMEEEMQRVSKQLLDS-KQHNE 1079
L +++NN+ + ++ + ++K+ ++ +L+ E Q K L+ S KQ E
Sbjct: 2747 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2806
Query: 1080 ELQILVRE----QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
E +IL +E Q Q K+ T + +++ TE + T+E + +A+
Sbjct: 2807 EKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 2857
Score = 97.9 bits (233), Expect = 3e-19
Identities = 219/1145 (19%), Positives = 473/1145 (41%), Gaps = 108/1145 (9%)
Query: 463 PSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
PS + G+ ED+ E + + ++ L E+K + K + L A +N
Sbjct: 155 PSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA-----TMN------ 203
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
++++ + +++ + Q +KT + S S+S + +R + S + E+ + LQ
Sbjct: 204 HRDIARHQASSSVFSWQQEKTPSHLS--SNSQRTPIRRDFSASYFSGE-QEVTPSRSTLQ 260
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ D +S S + +++ + I+ LE + +E+ K+ E++
Sbjct: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL 320
Query: 643 KL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+L A + ++ ++V ++ + + AS K AL + LK E L ++ E
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAE 379
Query: 701 NDKEDIMNKL---QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
+ + + K+ + QE + + + ++ ++ A++ E Q + A++
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
+ + +E+ L ++K ++CR E++ + + L R +++ K++SE
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE-NNLLKSHSEQK 498
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+E V L + + +++ L + ++ +E++ KN ++LQ ++ QQ +
Sbjct: 499 ARE---VCHLEAELKN---IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN--QQENS 550
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+EK LA ++ K + +DL LK+ H I Q ++ E E +
Sbjct: 551 LTLEKLK---LAVADLEKQRDCSQDL---LKKREHH----IEQLNDKLSKTEKESKALLS 600
Query: 938 SAIRDKKVLNEKYEKNIE--YVTQLEAQLQEYKNNIENLNMNVEELNK-MNLELIDKHVQ 994
+ KK K EK + + ++ E L + ++ ENL + L + + I H
Sbjct: 601 ALELKKKEYELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEY 660
Query: 995 KQQTQSPDYTEQYIN-EINKLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDY 1046
++ ++ + + ++ EI L+ +L K E+ + L QK + + + +
Sbjct: 661 NERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENM 720
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI 1106
K +Q T ++E++E ++Q +S +++D + ++L D +K K+ L N
Sbjct: 721 CLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS-KDASLV--TNE 777
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE-----FIQER----SVL 1157
++ M N+ +++ ++ +Q R
Sbjct: 778 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 837
Query: 1158 QEQSAKLNTELQECYTKIIQLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E ++N++LQ+ +++Q++ + L + ++Q + + ++ +L + +
Sbjct: 838 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 897
Query: 1217 VAELRSS----------ISSAVDQRGFEIAELWK-QHLAQREADFQKTEHELRVQLSAFE 1265
VAE S+ ++ V+ EI EL K HL + D K L LS +
Sbjct: 898 VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE---DSLKELQLLSETLSLEK 954
Query: 1266 SKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
+ ++ + +E T + T++++ + L ++ +L E +A+ I++ E S
Sbjct: 955 KEMSSIISLNKREIEELTQENGTLKEINA---SLNQEKMNLIQKSESFANYIDEREKSIS 1011
Query: 1326 EIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS-----ILNINEENAQLKKS 1380
E+ D+ DL +Q YK QE++ +LN + +K+
Sbjct: 1012 ELSDQYKQEKLILLQRCEETGNAYEDL---SQKYKAAQEKNSKLECLLNECTSLCENRKN 1068
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE--NVR 1438
+ + E +Q + + E Q+ +T Q N + E ++
Sbjct: 1069 ELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLK 1128
Query: 1439 QQLV-------EYEKRIEDLTYEKESELAILRLKMHENAN-HYETMQ---KESEIER--- 1484
Q+++ + +K + DL E E + +++ K HE N E ++ KE E ER
Sbjct: 1129 QEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRNSVKERESERNQC 1187
Query: 1485 -VKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLND--EIT 1541
K +L VK S N Q+ +L L + K E + E + E+ T+ E +
Sbjct: 1188 NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETS 1247
Query: 1542 NLQNM 1546
NLQ+M
Sbjct: 1248 NLQDM 1252
Score = 95.1 bits (226), Expect = 2e-18
Identities = 180/906 (19%), Positives = 393/906 (43%), Gaps = 96/906 (10%)
Query: 492 EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVK-SNHKLKLKQMQKTIDNFSKV 550
+IK+ ++ +E++K E + + + E A ++ + N K L Q Q +
Sbjct: 471 QIKENELRRSMEEMKK-ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAK 529
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAE 610
+ S + ++R +E ++Q+ L EK L+L + D + R D+ KK E+ E
Sbjct: 530 NTSQETMLRDLQE--KINQQENSLTLEK--LKLAVADLEKQRDCSQDLLKKR---EHHIE 582
Query: 611 TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD----------ISQLQSDQVCSEIK 660
+S E + L+ L + +++Y+ E+K ++Q++S++ + K
Sbjct: 583 QLNDKLSKTEKESKALLSALELKKKEYELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 642
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN--DKEDIMNKLQNY----I 714
HLE + E + L++D+E L I++L N D + + + Q +
Sbjct: 643 INHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMEL 702
Query: 715 QENMDLTDKLEKMSAE----KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESE 770
Q+ + +D+ + E K S+L ++ E K+Q + +I ++D +++ +E
Sbjct: 703 QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEH-KLQL---LSNEIMDKDRCYQDLHAE 758
Query: 771 LSKYKSRICRLEESIAVMEDRRYSL----ERKA--DQLGSYLQEK---QKAYSEYTIQED 821
+ + + S+ ED + SL ++ A + + E+ SE ++ D
Sbjct: 759 YESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD 818
Query: 822 ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ-HYNALV 880
+ A+L + +E L + N +LQK+ + L++ ++ +L +Q H + +
Sbjct: 819 QSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVA 878
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQIE 937
E + R + +++ +Q + + S L+ E Q L + ++ EI++L+ + N +E
Sbjct: 879 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK-KSNHLLE 937
Query: 938 SAIRDKKVLNEKY---EKNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKMNL---- 986
++++ ++L+E +K + + L +L + ++ +N ++ + KMNL
Sbjct: 938 DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQ-EKMNLIQKS 996
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
E ++ +++ + ++QY E KL +L Q+ EE + ++ + S
Sbjct: 997 ESFANYIDEREKSISELSDQYKQE--KL--ILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1052
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV----REQD-----DQIKELKE 1097
E L + T+ EN + E++++ + +K+H E L L R Q+ + +++
Sbjct: 1053 ECLLNECTSLCENRKNELEQLKEAF--AKEHQEFLTKLAFAEERNQNLMLELETVQQALR 1110
Query: 1098 TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL-KVQEEEEFIQ--ER 1154
+++T N K+E + I + ++ N + L KV + + Q E
Sbjct: 1111 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1170
Query: 1155 SVLQEQSAKLNTELQEC-YTKIIQLETLNTELTGHD---VVNQEQINQLKSKLEQLNTEN 1210
++ + +E +C + + LE L ++ V + + + KL++ E
Sbjct: 1171 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1230
Query: 1211 DNLLSTVAELRSSI--SSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKY 1268
+ L + +R + S+ D + EI+ L K E + HE LS ++
Sbjct: 1231 ECLQHELQTIRGDLETSNLQDMQSQEISGL-KDCEIDAEEKYISGPHE----LSTSQNDN 1285
Query: 1269 EQLLDSVQSSTQE--ETNKIVTM------EQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
L S+Q++ + E KI + E VT L + + R + E+ ++N++
Sbjct: 1286 AHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEV 1345
Query: 1321 EILRSE 1326
+IL +
Sbjct: 1346 KILNDD 1351
Score = 88.2 bits (209), Expect = 2e-16
Identities = 206/1116 (18%), Positives = 460/1116 (41%), Gaps = 97/1116 (8%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
E LK++ N E+++ K L ++K+ + ++ +Q + ++++ + +++ + Q +
Sbjct: 165 EDLKEKYNKEVEER--KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
KT + S S+S + +R + S + E+ + LQ+ D +S S
Sbjct: 223 KTPSHLS--SNSQRTPIRRDFSASYFSGE-QEVTPSRSTLQIGKRDANSSFFDNSSSPHL 279
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEI 659
+ +++ + I+ LE + +E+ K+ E++ +L A + ++ ++V ++
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL---QNYIQE 716
+ + AS K AL + LK E L ++ E+ + + K+ + QE
Sbjct: 340 RDELVRTTAQYDQASTKYTALE-QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398
Query: 717 NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
+ + + ++ ++ A++ E Q + A++ + + +E+ L ++K
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 777 RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV 836
++CR E++ + + L R +++ K++SE +E V L + +
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKE-NNLLKSHSEQKARE---VCHLEAELKN--- 511
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
+++ L + ++ +E++ KN ++LQ ++ QQ + +EK LA ++ K
Sbjct: 512 IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN--QQENSLTLEKLK---LAVADLEKQ 566
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE- 955
+ +DL LK+ H I Q ++ E E + + KK K EK +
Sbjct: 567 RDCSQDL---LKKREHH----IEQLNDKLSKTEKESKALLSALELKKKEYELKEEKTLFS 619
Query: 956 -YVTQLEAQLQEYKNNIENLNMNVEELNK-MNLELIDKHVQKQQTQSPDYTEQYIN-EIN 1012
+ ++ E L + ++ ENL + L + + I H ++ ++ + + ++ EI
Sbjct: 620 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 679
Query: 1013 KLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
L+ +L K E+ + L QK + + + + K +Q T ++E++E ++Q
Sbjct: 680 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 739
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
+S +++D + ++L D +K + +T N ++ M
Sbjct: 740 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT---NEDHQRSLLAFDQQPAMHHSF 796
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEE-----FIQER----SVLQEQSAKLNTELQECYTKII 1176
N+ +++ ++ +Q R E ++N++LQ+ +++
Sbjct: 797 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 856
Query: 1177 QLE-TLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA-------- 1227
Q++ + L + ++Q + + ++ +L + + VAE S++ +
Sbjct: 857 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN 916
Query: 1228 --VDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN 1284
V+ EI EL K HL + D K L LS + + ++ + +E T
Sbjct: 917 DKVETEQAEIQELKKSNHLLE---DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 973
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
+ T++++ + L ++ +L E +A+ I++ E SE+ D+
Sbjct: 974 ENGTLKEINA---SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEE 1030
Query: 1345 XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
DL +Q YK QE+ N + L ++ +A AK
Sbjct: 1031 TGNAYEDL---SQKYKAAQEK-----NSKLECLLNECTSLCENRKNELEQLKEAFAK--- 1079
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRL 1464
HQ E + + + L E E V+Q L + D +SE L+
Sbjct: 1080 -EHQ-EFLTKLAFAEERNQNLML-----ELETVQQAL---RSEMTDNQNNSKSEAGGLKQ 1129
Query: 1465 KMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM-- 1522
++ MQKE + + + V T+ N + + +++E ++ N+
Sbjct: 1130 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1189
Query: 1523 --QTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
Q LE +EI + + N ++ L+ M+R K+Q+
Sbjct: 1190 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE 1225
Score = 87.8 bits (208), Expect = 3e-16
Identities = 187/931 (20%), Positives = 382/931 (41%), Gaps = 79/931 (8%)
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+++ LK ++L I +LE + +++ + + +L +LEK E I E +N
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI-EKEKVLN 337
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKA 799
++T A+ + +E +L K + C+ + + E R SLE+K
Sbjct: 338 KCRDELVRT----TAQYDQASTKYTALEQKLKKLTEDLSCQRQNA----ESARCSLEQK- 388
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
++EK+K + E EL + D+ + + E ++ + + +L
Sbjct: 389 ------IKEKEKEFQE------ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
E L ++ + +K R + A S + +LR +K+ + ++
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
QK +E+ LE E + + + E KN T L LQE N EN ++ +E
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR-DLQEKINQQEN-SLTLE 554
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
K+ L + D ++KQ+ S D ++ + I +LN L + ++E AL + + Y
Sbjct: 555 ---KLKLAVAD--LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 1040 -----MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
++ S ++S+ + T++E+ +E +Q L + + QI E +++++
Sbjct: 610 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL---ETCLKTQQIKSHEYNERVRT 666
Query: 1095 LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
L+ + + I ++ S ++E + ++ K E E +
Sbjct: 667 LEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK--EIENMCLKT 724
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
S L Q L +LQ +I+ + +L + + LKSK L T D+
Sbjct: 725 SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE---YESLRDLLKSKDASLVTNEDHQR 781
Query: 1215 STVA-----ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
S +A + S ++ + ++G +E + L EAD Q ++ + +++ +
Sbjct: 782 SLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL---EAD-QSPKNS-----AILQNRVD 832
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
L S++S Q ++ E++ ++ ++ EE+L ++ + + + S++++
Sbjct: 833 SLEFSLESQKQMNSDLQKQCEELVQIKGEI---EENLMKAEQMHQSFVAETSQRISKLQE 889
Query: 1330 EKVAFXXXXXXXXXXXXXXXXDLRTENQSYK----QMQEQSILN--INEENAQLKKSSXX 1383
+ A +L+ N + ++QE N + + +L+ S
Sbjct: 890 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSET 949
Query: 1384 XXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVE 1443
++ + ++ ELT + EI ++ + L Q+++ F N + E
Sbjct: 950 LSLEKKEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQKSESFAN---YIDE 1005
Query: 1444 YEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNK 1503
EK I +L+ + + E IL + E N YE + ++ + + K +L + E SL +
Sbjct: 1006 REKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK-NSKLECLLNECTSLCE 1064
Query: 1504 QVAELNKALEEEVAKTN-EMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKH-VSFA 1561
+ L+E AK + E T L E L E+ +Q +R+ + Q + S A
Sbjct: 1065 NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEA 1124
Query: 1562 SDTKQG----RDEQLDNTMNKELLDAVPRAE 1588
KQ ++EQ N M KE+ D + E
Sbjct: 1125 GGLKQEIMTLKEEQ--NKMQKEVNDLLQENE 1153
Score = 82.6 bits (195), Expect = 1e-14
Identities = 196/1123 (17%), Positives = 464/1123 (41%), Gaps = 82/1123 (7%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELN-DEIKDVNVKDLIEKLKS 507
I + + E Q+ + + E + A++ ++L+Q N + + L +
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
Query: 508 AEEQITQLNDEIDAANK--NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK--EIVRLTEE 563
E + + ++ A + ++K N + + K +N K K E+ L E
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN-LAETRLK-AISLLES 621
L ++ Q + + + ++ ++ M+ D+ +K+ + EN L +LK A++ LE
Sbjct: 509 LKNIKQCLNQSQNFAEEMKAKNTSQET--MLR-DLQEKINQQENSLTLEKLKLAVADLEK 565
Query: 622 QKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVCSEI----KSVHLEEQIDALSASKK 676
Q+ D Q+L ++ + +++ DKL+ ++ +S + S + K L+E+ S K
Sbjct: 566 QR-DCSQDLLKKREHHIEQLNDKLSK-TEKESKALLSALELKKKEYELKEEKTLFSCWKS 623
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
E ++ ++ +KE L I LE + K Y + L E +S E + L
Sbjct: 624 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN--L 681
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
+ + +++TQ ++Q++ + + + + ++ + + +ED + L+
Sbjct: 682 HNVLDSKSVEVETQKLAYMELQQKAEFSD--QKHQKEIENMCLKTSQLTGQVEDLEHKLQ 739
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM---DHDR--VVEKQLLEIEHENKEL 851
++++ + Q ++EY D L ++ A L+ DH R + Q + H +
Sbjct: 740 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 799
Query: 852 QKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRIT 911
+ + E ++ ++ L + + + + + + L+ L +I
Sbjct: 800 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIK 859
Query: 912 HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI 971
E + +++ ++ + E + +I D + + + E +LQ + +
Sbjct: 860 GEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKV 919
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
E ++EL K N L++ +++ Q S + + E++ + +L K++ EE+ N
Sbjct: 920 ETEQAEIQELKKSN-HLLEDSLKELQLLSETLSLEK-KEMSSIISLNKREIEELTQENGT 977
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ S ++ + L Q + N +E ++ +L D Q+ +E IL++ ++
Sbjct: 978 LKEINAS----LNQEKMNLIQKSESFANYIDEREKSISELSD--QYKQEKLILLQRCEET 1031
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
++ ++ K +S +E + ++ ++ +E +EF+
Sbjct: 1032 GNAYEDLSQKYKAAQEK------NSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1085
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTEN 1210
+ + +E++ L EL+ + T N + + +++I LK + ++ E
Sbjct: 1086 TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV 1145
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ----KTEHELRVQLSAFES 1266
++LL +L + + + + E +E + + +RE++ K + +L V+ + +S
Sbjct: 1146 NDLLQENEQLMKVMKTKHECQNLE-SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1204
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR--NLQEKYADVINQIEILR 1324
QL+ +E + ++ LQ++LQ L NLQ+ + I+ ++
Sbjct: 1205 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1264
Query: 1325 SEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXX 1384
+ E++ ++ +L T +Q +N+ N +L+K
Sbjct: 1265 IDAEEKYIS--------------GPHELSTSQNDNAHLQCSLQTTMNKLN-ELEKICEIL 1309
Query: 1385 XXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEY 1444
+ND+ ++ + T ++ E+ + +E I ND+ + +LVE
Sbjct: 1310 QAEKYELVTELNDSRSECITATRKMA---EEVGKLLNEVKIL----NDDSGLLHGELVED 1362
Query: 1445 EKRIEDLTYEKESELAILRLKMHENANHYETM---QKESEIERVKLIEELNVKITESVSL 1501
E E+ +E + L + +N YE + KE ++ +L E+ +E L
Sbjct: 1363 IPGGE--FGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKIL 1420
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+ Q +++ +K +E+QT +++ + E + L+ + N Q
Sbjct: 1421 HDQHCQMS-------SKMSELQTYVDSLKAENLVLSTNLRNFQ 1456
Score = 81.0 bits (191), Expect = 3e-14
Identities = 167/797 (20%), Positives = 350/797 (43%), Gaps = 80/797 (10%)
Query: 233 KDEKQRLLKDIESKDVRISSLEE-----ANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++E +L + IE VRI + E+ A KL E R SL+ + LE+
Sbjct: 2110 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK--VENLERELQMSEE 2167
Query: 288 XXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
A+ S KT+IEE SL++ + +T + E E+L QI++ +L
Sbjct: 2168 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEK-ENLTKQIQEKQGQL- 2225
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
++L + + K++ ++ I +S + +++ +L+ D++I K
Sbjct: 2226 SELDKLLSSFKSLLEEKEQAEIQIKEES-KTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2284
Query: 407 IAKLEMVIQSLN--KDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQL------QLEHQQ 458
L+ I+ + ++ ++K E D + A L LE +
Sbjct: 2285 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2344
Query: 459 HMEGPSLIHVGTNTE----DVNEIAKVQEQLKQELND-EIKDVNVK----DLIEKLKSAE 509
+ + H E +V + E + Q L E+ V ++ +L +L+ +
Sbjct: 2345 EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ 2404
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
E+I++L + I+++ +N+++ K K+++K+ T + KE+ LH+ Q
Sbjct: 2405 ERISEL-EIINSSFENILQEKEQEKVQMKEKSSTA--MEMLQTQLKELNERVAALHN-DQ 2460
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+ + +E+ + Q+ ++ + ++++ L E + I +L+S L+QE
Sbjct: 2461 EACKAKEQNLSSQVECLELEKAQLLQG-----------LDEAKNNYI-VLQSSVNGLIQE 2508
Query: 630 LHILQQKYDEVEDKLADI-SQLQS-DQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
+ +QK ++ +++++ + +Q+Q +Q+ S++ V E Q+ KE L + NL +
Sbjct: 2509 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL------WKEQNLELRNLTV 2562
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNY---IQENMDLTDKLEKMS-AEKISELLAKINHEE 743
+ EQ ++ +D + LQ+ ++ ++LT K++KMS EK++++ AK E
Sbjct: 2563 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT-KMDKMSFVEKVNKMTAK-ETEL 2620
Query: 744 QSKIQTQFGIDAKIQERDLYIEN-IESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
Q ++ A++QE +N + EL I ++ + + L++ D +
Sbjct: 2621 QREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM 2680
Query: 803 GSYLQEKQ----KAYSEYTIQEDELVNR-LAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
EK+ + +EY ++ E + A+L+D ++ E +EI+ ++L K +
Sbjct: 2681 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE---VEIQTYREKLTSKEEC 2737
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT--QLRDLESNLKRITHEHQ 915
L + + + S ++ N+L KA L E + TK + L+ +R + +
Sbjct: 2738 LSSQKLEIDLLKSSKEELNNSL--KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2795
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
LI K+ E+ EI ++ + + EK + T ++ ++ E I+ L
Sbjct: 2796 LLIKSCKQLEEEKEI-----LQKELSQLQAAQEKQKTG----TVMDTKVDELTTEIKELK 2846
Query: 976 MNVEELNKMNLELIDKH 992
+EE K E +DK+
Sbjct: 2847 ETLEEKTKEADEYLDKY 2863
Score = 79.8 bits (188), Expect = 7e-14
Identities = 165/839 (19%), Positives = 363/839 (43%), Gaps = 101/839 (12%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
I N++ + + + RL + V+EDR +RK + L L E ++ S+ +QE +L
Sbjct: 1768 IHNLQLRVKETSNENLRL---LHVIEDR----DRKVESL---LNEMKELDSKLHLQEVQL 1817
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSD-MQQHYNALV 880
+ ++ ++ +++V E++ EN +L +K + ++Q L ++ S+ +
Sbjct: 1818 MTKIEACIELEKIVG----ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA 1873
Query: 881 EKANRTDLAESEST---KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+K++R D+ ++ + ++ + D+E+ L RI E K IE + +E
Sbjct: 1874 DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE--------KASIEHEALYLEADLE 1925
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN--LELIDKHVQK 995
+K L + E + + LE +L + L ++ ++K L+ + + +++
Sbjct: 1926 VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKE 1985
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + ++ I A +K+K E + L+ S VS+
Sbjct: 1986 KTQELESHQSECLHCIQVAEAEVKEKTELLQTLS-----------SDVSELLKDKTHLQE 2034
Query: 1056 KLENMEEEMQRVS--KQLLDSK--QHNEELQILVREQDDQIKELKETKLTFEMNIPKT-E 1110
KL+++E++ Q +S K L+++ Q N+E ++LV+E + L E+ ++N+ K E
Sbjct: 2035 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYE-KLNVSKALE 2093
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE---FIQERSVLQEQSAKLNTE 1167
++ + + + ++++ +E+ I E+ +E+ +
Sbjct: 2094 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD 2153
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQE-QINQLKSKLEQLNTENDNLLSTVAELRS---S 1223
E + +Q+ N EL D N + ++ LK+++E++ + LRS +
Sbjct: 2154 KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2213
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET 1283
++ + ++ +++EL K + + +K + E++++ ESK ++ +Q+ +E
Sbjct: 2214 LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE---ESK--TAVEMLQNQLKELN 2268
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE-DEKVAFXXXXXXXX 1342
+ + Q ++ E+ L E+ + N IE LR+ +E DEK
Sbjct: 2269 EAVAAL---CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2325
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
R EN +E I N+E+A L+ + V +AK+
Sbjct: 2326 SEHHADLLKGRVENLE----RELEIARTNQEHAALEAENSKG---------EVETLKAKI 2372
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
+T L + ++ +T R+++ EN+ +L + ++RI +L S IL
Sbjct: 2373 EGMTQSLRGLELDV----------VTIRSEK-ENLTNELQKEQERISELEIINSSFENIL 2421
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+ K E + KE +++++ T+ LN++VA L+ E AK +
Sbjct: 2422 QEKEQE-----KVQMKEKSSTAMEMLQ------TQLKELNERVAALHNDQEACKAKEQNL 2470
Query: 1523 QTALENQEIEIVTL---NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ +E E+E L DE N ++++S + + + V + +DE++ N+
Sbjct: 2471 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2529
Score = 77.4 bits (182), Expect = 4e-13
Identities = 231/1148 (20%), Positives = 457/1148 (39%), Gaps = 93/1148 (8%)
Query: 470 TNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDLIEKLKSAEE------QITQLNDEID 520
T +NE+ K+ E L K EL E+ D + + K AEE ++ LND+
Sbjct: 1294 TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSG 1353
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
+ +++ + + ++ + + + +SN LT + AEL+E+ +
Sbjct: 1354 LLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESN-SYEHLTLSDKEVQMHFAELQEKFLS 1412
Query: 581 LQL-HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI-LQQ-KY 637
LQ H + +D + S + + +++L L + L + + DLV+E+ + L++
Sbjct: 1413 LQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLV 1472
Query: 638 DEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK 697
+ S S S LE+ D S E A+ +D E +++
Sbjct: 1473 PSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVD-EVFCSSLQ 1531
Query: 698 DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ-TQFGIDAK 756
+ +++ + ++E L + + + S EK+ E + + +IQ + + ++
Sbjct: 1532 EENLTRKETPSAPAKGVEELESLCE-VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE 1590
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY 816
QE D + SE +++ +L ME + + +++ +QL L+ +
Sbjct: 1591 RQELDCLRKQYLSENEQWQQ---KLTSVTLEMESKLAAEKKQTEQLSLELE-----VARL 1642
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
+Q +L +R + +D + ++ + E +KE + ++ QI D QQ
Sbjct: 1643 QLQGLDLSSRSLLGIDTEDAIQGR-NESCDISKEHTSETTERTPKHDVHQICDKDAQQDL 1701
Query: 877 NALVEKANRTDL---------AESESTKYQTQLRDLESN----LKRITHEHQTLIVQ--- 920
N +EK T +S T Y+ D + ++ +V
Sbjct: 1702 NLDIEKITETGALKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDF 1761
Query: 921 --KKKEIEDLEIEF------NTQIESAI--RDKKV---LNEKYEKNIEYVTQLEAQLQEY 967
+++I +L++ N ++ I RD+KV LNE E + + Q E QL
Sbjct: 1762 LGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ-EVQLMTK 1820
Query: 968 KNNIENLNMNVEELNKMNLELIDK----HVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
L V EL K N +L +K Q+ T + +N +++A K E
Sbjct: 1821 IEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA-DKSSRE 1879
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE---------EMQRVSKQLLDS 1074
+I K+N+ S+ D E++L++ ++ ++E E+ + K L+
Sbjct: 1880 DIGDNVAKVND---SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEK 1936
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX- 1133
N++ I+ E++ + + +L E++ + + E M + ++
Sbjct: 1937 DNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1996
Query: 1134 -XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
+V+E+ E +Q S + K T LQE K+ LE + L+
Sbjct: 1997 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE---KLQSLEKDSQALSLTKCEL 2053
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ QI QL + E L E+++L + ++E S + E A + K A R + Q+
Sbjct: 2054 ENQIAQLNKEKELLVKESESLQARLSE--SDYEKLNVSKALEAALVEKGEFALRLSSTQE 2111
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
H+LR + + E D + E K E SL++K+++ E L+ +E
Sbjct: 2112 EVHQLRRGIEKLRVRIE--ADEKKQLHIAEKLKEREREN-DSLKDKVENLERELQMSEEN 2168
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY-KQMQEQSILNIN 1371
VI E ++E+E K LR+E ++ KQ+QE+ ++
Sbjct: 2169 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQ-GQLS 2226
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL-ELKDSEIYQKTHEYTITLTQR 1430
E + L +++ V L +QL EL ++ + + T++
Sbjct: 2227 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2286
Query: 1431 --NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLI 1488
+ E Q EK L +++ +L +L+ ++ E+ +H + ++ E L
Sbjct: 2287 SLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ-QLKESEHHADLLKGRVE----NLE 2341
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
EL + T + +E AK M +L E+++VT+ E NL N ++
Sbjct: 2342 RELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQ 2401
Query: 1549 ASSSKIQK 1556
+I +
Sbjct: 2402 KEQERISE 2409
Score = 71.3 bits (167), Expect = 3e-11
Identities = 141/730 (19%), Positives = 305/730 (41%), Gaps = 55/730 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
+V L I+E +L V ++ + + + +L ++I EK + +K +
Sbjct: 2182 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2241
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKD--EKQRLLKDIE-SKDVRISSLEEANKL 259
E++K + +Q + Q ++K E S D I +
Sbjct: 2242 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2301
Query: 260 LEAARFEISLEHSK---LAQELEQXXXXXXXXXXXXXXLAKQ-SIEPSCEEKTEIE---E 312
+E R + + K + Q+L++ L ++ I + +E +E
Sbjct: 2302 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2361
Query: 313 KGSLEI--ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLI 370
KG +E A + +T+ + LE IR + L N+L + + ++
Sbjct: 2362 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2421
Query: 371 SRKSGRNTASKMKSPWSQLSSETLNQDTDKKI----NKNEIAKL-EMVIQSLNKDL-VDK 424
K K KS + +T ++ ++++ N E K E + S + L ++K
Sbjct: 2422 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2481
Query: 425 EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ-HMEGPSLIHVGTNTED----VNEIA 479
++ D + LI +++ Q+ + + + +D V++++
Sbjct: 2482 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2541
Query: 480 KVQ--EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKL 537
+V+ QL +E N E++++ V +L +K++ + + L D ++ + +++ +L+L
Sbjct: 2542 QVEGEHQLWKEQNLELRNLTV-ELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN--ELEL 2598
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+M K + KV+ + L E+H ++QK AEL+EE + L + E
Sbjct: 2599 TKMDK-MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK 2657
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
K ++ L + LK L+ D V++ ++++ E + +L + + +
Sbjct: 2658 SSKDQLKELTLENSELK--KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2715
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
K +E Q + KE L + L++D L++ KE++ N L+ Q
Sbjct: 2716 TNKQYEVEIQTYREKLTSKEECLSSQKLEIDL---------LKSSKEELNNSLKATTQIL 2766
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
+L K KM K L K N Q K++ +++E E ++ ELS+ ++
Sbjct: 2767 EEL--KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEK---EILQKELSQLQAA 2821
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR-LAVLMDHDRV 836
+ +++ VM+ K D+L + ++E ++ E T + DE +++ ++L+ H+++
Sbjct: 2822 QEK-QKTGTVMDT-------KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2873
Query: 837 VE-KQLLEIE 845
+ K++LE +
Sbjct: 2874 EKAKEMLETQ 2883
Score = 37.5 bits (83), Expect = 0.40
Identities = 91/601 (15%), Positives = 227/601 (37%), Gaps = 14/601 (2%)
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
T+ ++QE + ++ L ++ + L+ ++ QKQ TQ + + + + N
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQ-RQFQLDSLEAAPQKQ-TQKVENEKTEGTNLKRENQR 71
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L + E + QKI++ S V+ E +L ++E +E+E++R +L S+Q
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
+ + + + +++ T LT ++ + ++ ++
Sbjct: 132 AQSADVSLNPCNTP-QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI---IQLETLNTELTGHDVVNQE 1194
+ + ++ + Q S+ + + ++ + + Q + + + ++
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQ 250
Query: 1195 QINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
++ +S L Q+ + N S+ + SS +DQ + EL + + + E Q E
Sbjct: 251 EVTPSRSTL-QIGKRDAN--SSFFD-NSSSPHLLDQLKAQNQEL-RNKINELELRLQGHE 305
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYA 1314
E++ Q++ F+ QL + ++E +++ + L++K
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365
Query: 1315 DVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
+ + R E + + + Q+ Q Q + +E
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL 425
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEF 1434
Q K E + E +L + + +Q + L + +E
Sbjct: 426 QQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL-CRAEQAFQASQIKENELRRSMEEM 484
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVK 1494
+ L + ++ E+EL ++ ++++ N E M K + ++ +L K
Sbjct: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM-KAKNTSQETMLRDLQEK 543
Query: 1495 ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
I + + + + +L A+ + + + Q L+ +E I LND+++ + +A S +
Sbjct: 544 INQQEN-SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602
Query: 1555 Q 1555
+
Sbjct: 603 E 603
>M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein.
Length = 1976
Score = 124 bits (299), Expect = 3e-27
Identities = 221/1105 (20%), Positives = 467/1105 (42%), Gaps = 98/1105 (8%)
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+++ KD E+L +E+ T++ E++ + ++ + +Q+Q + F++ +
Sbjct: 852 EELQAKD--EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 554 NKEIV----RLTEELHHLSQKVAELEE-------EKGNLQLHLVDYDSGRMIESDVYKKM 602
+ L E LH L +V E EE EK +Q H+ D + ++ E + ++
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE-QLDEEEGARQK 968
Query: 603 IEMENL-AETRLK----AISLLESQKFDLVQELHILQQKYDEVEDKLAD----ISQLQSD 653
+++E + AE ++K I LLE Q ++E +++ + E +LA+ L
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI---MNKL 710
+ E+ LEE++ +++EL L + L I +L+ +++ + K
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 711 QNYIQENMDLTD--KLEKMSAEK-ISELLAKINH-EEQSKIQTQFGIDAKIQERDLYIEN 766
+ +Q + D L K +A K + EL A+I +E + + A+ Q+RDL
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL---- 1144
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL K+ + ++ A ++ R E++ +L L+E+ K + Q ++ R
Sbjct: 1145 -SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK---NHEAQIQDMRQR 1200
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
A ++ + +QL + + L+K Q L +N+ L + +QQ K +
Sbjct: 1201 HATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 887 D-------LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
D SE + + +L + S L+ TL+ + +K+ + +ES
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD-AASLESQ 1316
Query: 940 IRD-KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
++D +++L E+ + + +++ QL+E KN+++ EE K NLE +Q Q
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIR-QLEEEKNSLQEQQEEEEEARK-NLEKQVLALQSQLA 1374
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + I L K+ ++ AL+Q++ ++Y + +++L Q L
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-DKLEKTKNRLQQELDDL- 1432
Query: 1059 NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISST 1117
++ + QR L+ KQ + Q+L E+ + +E + E +T+ + ++
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEE------EFIQERSVLQEQSAKLNTELQEC 1171
+E + + L +++ E + + L++Q ++ T+L+E
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
++ E L + + Q + L+++ EQ + L+ V EL + + Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 1231 RGFEIAELWKQHL------AQREA------DFQKTEHELRVQLSAFESKYEQL---LDSV 1275
R +A K + AQ EA + K +L+ Q+ ++ + E+ D +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 1276 QSSTQEETNKIVTME-QVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ ++E K+ ++E ++ LQ +L E H +++ AD I +S + DEK
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
++ N +++ Q + +N E A + ++
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-VDTLNAELAAERSAAQKSDNARQQL 1790
Query: 1392 XXRVNDAEAKVLELTHQLELK----DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKR 1447
+ + +AK+ EL ++ K S + K + L Q E + + EK+
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQK-ESEIERVK-LIEELNVKITE-SVSLNKQ 1504
++++ + E E + H + + E M+K + ++++K +EE + T + S K
Sbjct: 1851 LKEIFMQVEDE------RRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 1505 VAELNKALEEEVAKTNEMQTALENQ 1529
EL+ A E + E+ T L+N+
Sbjct: 1904 QRELDDATEANEGLSREVST-LKNR 1927
Score = 124 bits (298), Expect = 4e-27
Identities = 181/985 (18%), Positives = 421/985 (42%), Gaps = 69/985 (7%)
Query: 595 ESDVYKKMIEMENLAETRLKA---ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQ 651
E ++ K E+ + E + K + +E + L++E +IL ++ + A+ +++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
+ K LEE + L + +E + L+ +K+++ I+DLE ++ Q
Sbjct: 911 ARLAA---KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 712 NYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
E + K++KM E + + +K E++ +++ E + +N+
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK 1027
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
+K + I LEE + E R LE+ +L + Q +E Q DEL +LA
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA- 1086
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ E Q +++ L K N L+ + LQ ++++Q+ + + EKA+R A
Sbjct: 1087 ----KKEEELQGALARGDDETLHKNNA--LKVVRELQAQIAELQEDFES--EKASRNK-A 1137
Query: 890 ESESTKYQTQLRDLESNLKRI---THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
E + +L L++ L+ T Q L ++++E+ +L+ + ++ + +
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+++ +E +++ Q + +K N+E +E NK L K +Q+ + +S ++
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKK 1256
Query: 1007 YINEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
++ +L+A + + D E+ K+ N + +++ + E K +F ++E +
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +R+ +++ L+E + E E +++ + ++D
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ-LAD 1375
Query: 1124 DANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETL 1181
VD K + ++ E + +R E+ A +L++ ++ Q L+ L
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTKNRLQQELDDL 1432
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV---DQRGFEIAEL 1238
+L H + + + K +QL E ++ + AE R + + + +A
Sbjct: 1433 TVDLD-HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
++ L +E +F++ +LR + S + + +V + E +K +QV ++ +
Sbjct: 1492 LEEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH---ELEKSKRALEQQVEEMRTQ 1547
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
L++ E+ L+ ++ + ++ ++++ E + +L E +
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1359 YKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
++ + ++ + + LK N A +V++ +L+ + + YQ
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAA--------NKARDEVIKQLRKLQAQMKD-YQ 1658
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
+ L + + + Q E EK+++ L E+E+ L++ E E ++
Sbjct: 1659 RE------LEEARASRDEIFAQSKESEKKLKSL----EAEI----LQLQEELASSERARR 1704
Query: 1479 ESEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
+E ER +L +E+ + + E L ++A+L + LEEE + + +
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQK 1556
++ TLN E+ ++ + S + Q+
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQ 1789
Score = 120 bits (288), Expect = 6e-26
Identities = 186/1039 (17%), Positives = 440/1039 (42%), Gaps = 73/1039 (7%)
Query: 445 KDTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K+ L QLQ E + E + + +++ EI E +E +E ++ +++ +
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKK 946
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
K+++ + + + DE + A + + K + K+K+M++ I + D N + ++
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI---LLLEDQNSKFIKEKKL 1003
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
+ + + S ++AE EE+ NL + ++ SD+ +++ + E + KA L
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIR---NKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKEL 678
+ + DL ++ LQ + DE++ +LA + LQ + +++H + + + ++
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT---DKLEKMSAEKISEL 735
A + E+ + +K K + D + + L+ +++ +D T +L ++++EL
Sbjct: 1121 AELQEDFESEKASRNKAEKQ-KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 736 LAKI-----NHEEQSKIQTQFGIDA------KIQERDLYIENIESELSKYKSRICRLEES 784
+ NHE Q + Q A ++++ + N+E ++ L
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ V++ + E K +L + +QE SE EL + + L + V L E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E + + K L + Q+ Q L + + L + + + ++ + Q + +
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA----IRDKKVLNEKYEKNIEYVTQL 960
NL++ Q+ + KK+++D ++ +E A ++D + L+++ E+ +L
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDD-DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 961 EAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
E + +++L ++++ ++ NLE K + + + +Y E ++ A
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK---QLLDSK 1075
++K+ + ++L + + A + ++E + Q +E++ V K +L SK
Sbjct: 1479 REKETKALSLARALEEA----LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 1076 ----QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
Q EE++ + E +D+++ ++ KL E+N+ + M + + D N +
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM---QAMKAQFERDLQTRDEQN-EEK 1590
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
L+ + E+E ++R++ K+ +L++ +I E+
Sbjct: 1591 KRLLIKQVRELEAELEDE-RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
Q Q+ + +LE+ D + + E + S EI +L ++ LA E +
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL----EAEILQL-QEELASSERARR 1704
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
E E R +L+ +++ +S + K ++ L+ +L++++ ++ L +
Sbjct: 1705 HAEQE-RDELA------DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 1312 KYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ----SYKQMQEQSI 1367
++ Q++ L +E+ E+ A +L+ + Q + K + +I
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSA-AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ + QL++ V E K+ E+ Q+E + + +Y +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE----DERRHADQYKEQM 1872
Query: 1428 TQRNDEFENVRQQLVEYEK 1446
+ N + +++QL E E+
Sbjct: 1873 EKANARMKQLKRQLEEAEE 1891
Score = 119 bits (287), Expect = 8e-26
Identities = 211/1064 (19%), Positives = 447/1064 (42%), Gaps = 86/1064 (8%)
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
Q+T+ +E+ A ++ ++KVK + K++ + ++ + K I L E+L ++
Sbjct: 846 QVTRQEEELQAKDEELLKVKEK-QTKVEGELEEMERKHQQLLEEKNI--LAEQLQAETEL 902
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
AE EE + L + ++ + + ++E+ E + +L+++K + +
Sbjct: 903 FAEAEEMRARLAAK----------KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
L+++ DE E +LQ ++V +E K +EE+I L + I+ KL ++
Sbjct: 953 QDLEEQLDEEEGAR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKF---IKEKKLMED 1006
Query: 691 QLYGTIKDLENDKEDIMN--KLQNYIQENM--DLTDKLEKMSAEKISELLAKINHE---E 743
++ L ++E N K++N QE M DL ++L+K EK + L K + E
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNK-QEVMISDLEERLKK--EEKTRQELEKAKRKLDGE 1063
Query: 744 QSKIQTQFG-IDAKIQERDLYI----ENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q + A+I E L + E ++ L++ ++ V+ + + +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEKQLLEIEHENKELQKKNQI 857
+ S + KA + +EL L D D +Q L + E +E+ + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-QEVAELKKA 1182
Query: 858 LLEENQNLQISLSDM-QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
L EE +N + + DM Q+H AL E + + + A+ + + LE++ K + E +
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L Q K E E + + Q++ L+ K + +L + + +N ++N++
Sbjct: 1243 L-QQVKAESEHKRKKLDAQVQE-------LHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+EE K ++ K ++Q D T++ + E + L + ++ + Q
Sbjct: 1295 LLEEAEKKGIKFA-KDAASLESQLQD-TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ E ++ ++L + + ++V L + E + L+++ + + L+
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTK---KKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
E L ++ + KT+ + + D + ++ EE+ I R
Sbjct: 1410 EKALAYD-KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR-- 1466
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E+ + E +E TK + L E + Q QL++ +E L + D++
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH---ELRVQLSAFESKYEQLLD 1273
V EL S A++Q+ E + L + E + Q TE L V + A ++++E+ D
Sbjct: 1527 VHELEKS-KRALEQQ----VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--D 1579
Query: 1274 SVQSSTQEETNKIVTMEQVTSLQNKLQD--KEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
Q E K + ++QV L+ +L+D K+ L +K ++ ++ L ++IE
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI--DLKDLEAQIEAAN 1637
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
A L+ + + Y++ E++ + +E AQ K+S
Sbjct: 1638 KA--------RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
+ + H + +D E+ + + DE + ++ + E+ +E
Sbjct: 1690 LQLQEELASSERARRHAEQERD-ELADEITNSASGKSALLDEKRRLEARIAQLEEELE-- 1746
Query: 1452 TYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
E++S + +L + + +T+ E ER + N + L +Q EL
Sbjct: 1747 --EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR----QQLERQNKELKAK 1800
Query: 1512 LEE-EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
L+E E A ++ + + E +I L +++ + RA+++K+
Sbjct: 1801 LQELEGAVKSKFKATISALEAKIGQLEEQLEQ-EAKERAAANKL 1843
Score = 115 bits (276), Expect = 2e-24
Identities = 163/851 (19%), Positives = 349/851 (41%), Gaps = 67/851 (7%)
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQEKQKAYSEYTI 818
L + E EL + +++E +E +ERK QL + L E+ +A +E
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+ +E+ RLA +E+ L ++E +E +++NQIL E + +Q + D+++ +
Sbjct: 905 EAEEMRARLAAKKQE---LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
E+ R L + E + +++ +E + + + + +++KK +ED E ++Q+
Sbjct: 962 --EEGARQKL-QLEKVTAEAKIKKMEEEIL-LLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
K L + K ++ LE +L++ + + L +L+ +L D+ + + Q
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ-IAELQA 1076
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQK---INNAQVSYMSMVSDYESKLA---Q 1052
Q + Q + +L L + D+E + N + Q + D+ES+ A +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK-----ETKLTFEMNIP 1107
+ ++ EE++ + +L D+ Q L +++ ++ ELK ETK E I
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-NHEAQIQ 1195
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA----- 1162
++ +E +S+ L+ + +E E VLQ+ A
Sbjct: 1196 DMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLET-DNKELACEVKVLQQVKAESEHK 1253
Query: 1163 --KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
KL+ ++QE + K+ + + L EL Q +++ + + LE+ + A L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
S + + E + K +L+ R ++ ++ L+ Q E + L
Sbjct: 1314 ESQLQDTQELLQEETRQ--KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL--------- 1362
Query: 1281 EETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
E + Q+ + K+ D + +L+E ++ E L +E++ +A+
Sbjct: 1363 -EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQ---EQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
DL + +Q+ E+ ++ A+ K S +
Sbjct: 1422 KNRLQQELD-DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 1398 AEAKVLELTHQLE--LKDSEIYQKTHEYTIT-----LTQRNDEFENVRQQLVEYEKRIED 1450
E K L L LE L+ E +++ ++ ++ ++D +NV + L + ++ +E
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQ 1539
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS----LNKQVA 1506
E ++L L ++ + ++ + + + +L + ++ L KQV
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 1507 ELNKALEEE-------VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
EL LE+E VA +M+ L++ E +I N + +R ++++ +
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1560 FASDTKQGRDE 1570
+ + RDE
Sbjct: 1660 ELEEARASRDE 1670
Score = 109 bits (261), Expect = 1e-22
Identities = 197/1012 (19%), Positives = 433/1012 (42%), Gaps = 102/1012 (10%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H L + ++E++ +LQ + K M+ I DL+E+++E++ K +
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG-ARQKLQLEKVTAE 977
Query: 199 XXXXXXXXXXXXXEDTKQQM---TKMQENFIA----MEAEWKDEKQRLLKDIESKDVRIS 251
ED + K+ E+ IA AE +++ + L K ++V IS
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LEE K E R E+ KL E L Q K E E
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL------AKKEEE 1091
Query: 312 EKGSLEIANMTELTKK--IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL 369
+G+L + L K ++++ L QI + ++ E++ A+ K S++
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE---- 1147
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS 429
+K+ T Q + + E+A+L+ ++L ++ + E I
Sbjct: 1148 ---------LEALKTELEDTLDTTAAQQELRTKREQEVAELK---KALEEETKNHEAQIQ 1195
Query: 430 EKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL 489
+ + + + +++ +G + T+ +++ KV +Q+K E
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQG-----LETDNKELACEVKVLQQVKAES 1250
Query: 490 NDEIK--DVNVKDLIEKLKSAE-------EQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
+ K D V++L K+ + E+ ++L +E+D + +++ +K +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS-TLLEEAEKKGIKFAKD 1309
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDV- 598
+++ S++ D+ + + T + +LS ++ +LEEEK +LQ + + R +E V
Sbjct: 1310 AASLE--SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 599 --YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE---VEDKLADI-SQLQS 652
++ + + + L I LE K L+++ L Q+ +E DKL ++LQ
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 653 D------------QVCSEIKSVHLEEQIDALSASKKELA--LVIENLKLDKEQLYGTIK- 697
+ QV S ++ +++ D L A +K ++ E + + E K
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEK--KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 698 -DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK 756
L E+ + + + ++N L +E + + K ++ ++ E+SK ++ +
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSK-DDVGKNVHELEKSK----RALEQQ 1540
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVME---DRRYSLERKADQLGSYLQEKQKAY 813
++E +E +E EL + RLE ++ M+ +R + ++ L KQ
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E ++++ LAV + +E L ++E + + K ++++ + LQ + D Q
Sbjct: 1601 LEAELEDERKQRALAVA--SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ +A+R ++ ++S + + +L+ LE+ + ++ E + ++ E E
Sbjct: 1659 RELEE--ARASRDEIF-AQSKESEKKLKSLEAEILQL-QEELASSERARRHAEQERDELA 1714
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN----MNVEELNKMNLELI 989
+I ++ K L ++ + + QLE +L+E ++N+E LN +++ +N EL
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 990 DKHVQKQQTQSPDYTEQYINEINK-LNALLKQKDEEIIA-LNQKIN--NAQVSYMSMVSD 1045
++ Q D Q + NK L A L++ + + + I+ A++ + +
Sbjct: 1775 ---AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 1046 YESKLAQFTTKL-ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
E+K KL E++++ + Q+ D ++H ++ + + + + ++K+LK
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Score = 100 bits (240), Expect = 4e-20
Identities = 200/1006 (19%), Positives = 424/1006 (42%), Gaps = 76/1006 (7%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKN-KATTXXXXXXXX 202
VT ++ KD L ++ K +E +L+E + Q++E KN A
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEG---ELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESK-DVRISSLEEANKLLE 261
K+Q + + + E ++E+ ++L++ + K I LEE E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 262 AARFEISLE----HSKLAQELEQ--XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS 315
AR ++ LE +K+ + E+ L + I + E EEK
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 316 --LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
+I N E+ I LE + +T +ELE + E+ + + I
Sbjct: 1024 NLAKIRNKQEV--MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID-- 1079
Query: 374 SGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDT 433
++ +L L + D+ ++KN K+ +Q+ +L +E SEK +
Sbjct: 1080 ---ELKLQLAKKEEELQG-ALARGDDETLHKNNALKVVRELQAQIAEL--QEDFESEKAS 1133
Query: 434 XXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI 493
+ L A L+ E + ++ + T+ E+A++++ L++E +
Sbjct: 1134 RNKAEKQKRDLSEELEA-LKTELEDTLD-TTAAQQELRTKREQEVAELKKALEEETKNH- 1190
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SD 552
+ ++D+ ++ +A E++++ ++ N+ K K + K++ + +V ++
Sbjct: 1191 -EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI-EMENLAET 611
S + +L ++ L KV+E + L++ L + S E D ++ E E
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGD----RLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
K + LESQ D QEL LQ++ + + + I QL+ ++ + ++ EE+
Sbjct: 1306 FAKDAASLESQLQD-TQEL--LQEETRQKLNLSSRIRQLEEEK--NSLQEQQEEEEEARK 1360
Query: 672 SASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTDKLEK 726
+ K+ LAL + + K + GTI+ LE K+ ++ L ++E DKLEK
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ ++ + L + + + Q ++ K ++ D + +S ++Y R E
Sbjct: 1421 -TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVLMDHDRVVEK 839
E + SL R ++ +E ++ + ++L++ + L R +E+
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
Q+ E+ + +EL+ + Q + L++++ M+ + + R + E + Q
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--DLQTRDEQNEEKKRLLIKQ 1597
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R+LE+ L+ + + KKK DL+ + QIE+A N+ ++ I+ + +
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLK-DLEAQIEAA-------NKARDEVIKQLRK 1649
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
L+AQ+++Y+ +E + +E+ + E +K ++ + + E+ + +
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKE-SEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLE----NMEEEMQRVSKQLL 1072
++DE L +I N+ +++ + E+++AQ +LE NME R K L
Sbjct: 1709 ERDE----LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 1073 DSKQHNEEL---QILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
N EL + ++ D+ ++L+ + + + EG + S
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Score = 97.1 bits (231), Expect = 5e-19
Identities = 173/795 (21%), Positives = 333/795 (41%), Gaps = 94/795 (11%)
Query: 839 KQLLEIEHENKELQKKNQILL---EENQNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
K LL++ + +ELQ K++ LL E+ ++ L +M++ + L+E+ N LAE
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI--LAE----- 894
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
QL+ E+ L E + + KK+E+E++ + +++E ++L + +K
Sbjct: 895 ---QLQ-AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 956 YVTQLEAQLQEYKNNIENLNMN----VEELNKMNLELI------DKHVQKQQTQSPDYTE 1005
++ LE QL E + + L + ++ KM E++ K +++++ E
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 1006 ---QYINEINKLN--ALLKQKDEEIIA-LNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
Q E K A ++ K E +I+ L +++ + + + + KL TT L++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQD 1069
Query: 1060 MEEEMQ-RVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
E+Q ++ + L + EELQ L R D+ + + K+ E+ E +
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE---LQED 1126
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
E N + LK E E+ + + QE K E+ E K ++
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKT-ELEDTLDTTAAQQELRTKREQEVAE-LKKALE 1184
Query: 1178 LETLNTELTGHDVVNQ------------EQINQLKSKLEQ----LNTENDNLLSTVAELR 1221
ET N E D+ + EQ + K+ LE+ L T+N L V L+
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+ + +R A++ + H E D LRV+L+ SK + LD+V + +E
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGD------RLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 1282 ETNK-IVTMEQVTSLQNKLQDKEEHLR-------NLQEKYADVINQIEILRSEIEDEKVA 1333
K I + SL+++LQD +E L+ NL + + + L+ + E+E+ A
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 1334 -------FXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
DL T +S ++ +++ + + + +L++ +
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ + ++L HQ ++ S + +K ++ L E +++ + E
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVA-SNLEKKQKKFDQLLA----EEKSISARYAEERD 1472
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVA 1506
R E EKE++ L + E E +++++ R + E+L ++ + K V
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM-EDL---MSSKDDVGKNVH 1528
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
EL K+ + EM+T LE E E+ D L+ ++A ++ ++ + Q
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-------Q 1581
Query: 1567 GRDEQLDNTMNKELL 1581
RDEQ N K LL
Sbjct: 1582 TRDEQ--NEEKKRLL 1594
Score = 51.2 bits (117), Expect = 3e-05
Identities = 105/596 (17%), Positives = 253/596 (42%), Gaps = 39/596 (6%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E++ A L+ ++ +++ + D ++K+++ IE+ +A
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---- 1408
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
E+ K+++ ++ E D L D++ + S+LE+ K + E
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDD----LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL-TKKIEL 330
++ A+E ++ LA+ ++E + E K E E + A+M +L + K ++
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
++++ ++ ++ + LE ++ M T+ + + + R A K + +
Sbjct: 1524 GKNVH-ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLV-----DKEYVISEKDTXXXXXXXXXXGK 445
+ N++ + + K ++ +LE ++ K K+ I KD +
Sbjct: 1583 RDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA-R 1640
Query: 446 DTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
D +I QL+ L+ Q L + +++ +K E+ + L EI + ++L
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ-EELASS 1699
Query: 505 LKS---AEEQITQLNDEI--DAANKN-MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++ AE++ +L DEI A+ K+ ++ K + ++ Q+++ ++ SN E++
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE----EQSNMELL 1755
Query: 559 --RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA- 615
R + + AEL E+ Q ++ K+ E+E +++ KA
Sbjct: 1756 NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDA 670
IS LE++ L ++L + K +KL ++ + ++ +++ +EQ++
Sbjct: 1816 ISALEAKIGQLEEQLE-QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 671 LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
+A K+L +E + + + + + L+ + +D + +E L ++L +
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 45.2 bits (102), Expect = 0.002
Identities = 62/312 (19%), Positives = 132/312 (42%), Gaps = 19/312 (6%)
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED--EKVAFXXXXXXXX 1342
K+ + QVT + +LQ K+E L ++EK V ++E + + + E+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
++R + KQ E+ + ++ + ++ + + D E ++
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 1403 LE-----LTHQLELKDSEI-YQKTHEYTITLTQRNDEF----ENVRQQLVEYEKRIEDLT 1452
E QLE +E +K E + L +N +F + + ++ E ++ +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE-E 1018
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
EK LA +R K + E K+ E R +L + E+ L Q+AEL +
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 1513 EE---EVA-KTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+E ++A K E+Q AL + E + N+ + ++ + +A +++Q+ + + +
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAELQEDFE-SEKASRNK 1136
Query: 1569 DEQLDNTMNKEL 1580
E+ +++EL
Sbjct: 1137 AEKQKRDLSEEL 1148
>M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy chain
protein.
Length = 1937
Score = 124 bits (299), Expect = 3e-27
Identities = 214/1129 (18%), Positives = 460/1129 (40%), Gaps = 86/1129 (7%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
K++ LK E + +K+ +K K + E++ ++K K++ +L Q
Sbjct: 838 KIKPLLKSA-ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL---Q 893
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV------------- 586
+Q D+ + + +++++ +L ++V E EE+ + L
Sbjct: 894 VQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 587 --DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
D D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 954 KKDIDDLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 645 ADISQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK 703
Q + D+V K+ LE+Q+D L S ++ + +L+ K +L G +K +
Sbjct: 1014 ----QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
D+ N + L +KLEK E IS L++KI E+ +IQ Q KI+E
Sbjct: 1070 MDMEN-------DKQQLDEKLEKKEFE-ISNLISKIEDEQAVEIQLQ----KKIKELQAR 1117
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
IE + E+ ++ + E+ + + + + ++ G + + + + +L
Sbjct: 1118 IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKL 1177
Query: 824 VNRL-AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
L + H+ +V + EL ++ L Q L+ S+++ + L
Sbjct: 1178 RRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSN 1237
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESA 939
A A+ K L D S LK E Q LI ++ ++ E++ Q++
Sbjct: 1238 AEAISKAKGHLEKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEQ 1297
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
L+ + + + + +L+ QL+E + +N + + ++ + +L+ + +++Q
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEE-ETKAKNALAHALQSSRHDCDLLREQYEEEQEG 1356
Query: 1000 SPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++ +++ N A + K E + I +++ A+ + + E + K
Sbjct: 1357 KAE-LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 1059 NMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
++E+ QR+ + +LD ++ N L ++Q + K L E K +E +T+ +
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE----ETQAELE 1471
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+S E S + + E + LQ++ + L ++ E +
Sbjct: 1472 ASQKESRSLSTE------LFKVKNVYEESLDQLETLRRAHKNLQQEISDLTEQIAEGGKQ 1525
Query: 1175 IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
I +LE + ++ Q + + ++ LE + + + +++S + + ++ E
Sbjct: 1526 IHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1585
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-EETNKIV--TMEQ 1291
I +L + H E + E+R + A K + D + Q N++ ++
Sbjct: 1586 IDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRN 1645
Query: 1292 VTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIED-----EKVAFXXXXX 1339
+ Q L++ + HL +L+E+ A V + +L++EIE+ E+
Sbjct: 1646 YRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705
Query: 1340 XXXXXXXXXXXD-LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
L T+N S +++ ++++ +++++ + DA
Sbjct: 1706 EQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 1399 EAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDL 1451
EL + + E +K E T+ L R DE E + ++Q+ + E R+ +L
Sbjct: 1766 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1825
Query: 1452 TYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV-SLNKQV 1505
E E+E A+ L+ H+ T Q E + + V +++L K+ V S +Q
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHDRRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQA 1885
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
E + ++K ++Q LE E ++ L+ R +KI
Sbjct: 1886 EEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 105 bits (253), Expect = 1e-21
Identities = 210/1072 (19%), Positives = 443/1072 (41%), Gaps = 82/1072 (7%)
Query: 474 DVNEIAKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
+ + +A +E+ +Q + ++I+ + +K++ E+ + EE +N E+ A + + S
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEE----INAELTAKKRKLEDECSE 952
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELEEEKGNLQ-LHLVDYDS 590
K + ++ T+ K + + V+ LTEE+ L + +A+L +EK LQ H D
Sbjct: 953 LKKDIDDLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 591 GRMIESDV----------YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQ------ 634
+ E V +++ ++E E K LE K L +L + Q
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 635 ----QKYDE-VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
Q+ DE +E K +IS L S + + L+++I L A +EL IE + +
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELL--AKINHEEQS 745
+ DL + E+I +L+ + +K AE K+ L A + HE
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 746 KIQTQFGID--AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
+ D A++ E+ ++ ++ +L K KS + + ++ + + +++
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGHLEKMC 1252
Query: 804 SYLQEKQKAYSEYTIQEDELVNRL----AVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
L+++ ++ L+N L A L +QL E + +L + Q
Sbjct: 1253 RSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEQDALVSQLSRSKQAST 1312
Query: 860 EENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
++ + L+ L + + NAL +++R D + +Y+ + ++ ++ L+R + +
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHD-CDLLREQYEEE-QEGKAELQRALSKANSE 1370
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV----TQLEAQLQEYKNNIEN 973
+ Q + + E I+ ++E A + ++ E+++E V LE Q +N +E+
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L ++VE N L K+Q ++ + + A L+ +E +L+ ++
Sbjct: 1431 LMLDVERSNAACAAL-----DKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ Y + E+ +N+++E+ +++Q+ + + EL+ + ++ + +
Sbjct: 1486 KVKNVYEESLDQLET----LRRAHKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKC 1541
Query: 1094 ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
E++ E ++ EG I+ +E ++ + VD LK
Sbjct: 1542 EIQAALEEAEASLEHEEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETM 1600
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK---LEQLNTEN 1210
+S L + N L+ L + +L + + E + ++ L++
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHL 1660
Query: 1211 DNLLSTVAELRSSISSAVDQRG----FEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
D+ L +L+ + + V++R EI ELW L Q E + E EL L A S
Sbjct: 1661 DDALRGQEDLKEQL-AIVERRANLLQAEIEELWAT-LEQTERSRKIAEQEL---LDA--S 1713
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE 1326
+ QLL + +S K+ V+ LQ+++++ + RN +EK I ++ E
Sbjct: 1714 ERVQLLHTQNTSLINTKKKL--ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEE 1771
Query: 1327 IEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
++ E+ DL Q EQ L ++ Q K +
Sbjct: 1772 LKKEQDT-SAHLERMKKNLEQTVKDL----QHRLDEAEQLALKGGKKQIQ-KLEARVREL 1825
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ +AEA H +K E+ +T E + + D + ++ ++ Y++
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHDRRVK--ELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKR 1883
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQ-KESEIERVKL-IEELNVKIT 1496
+ E+ + + L+ R HE E ES++ ++++ E++ KI+
Sbjct: 1884 QAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935
Score = 105 bits (251), Expect = 2e-21
Identities = 201/998 (20%), Positives = 429/998 (42%), Gaps = 91/998 (9%)
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS----QLQSDQVCSEIKS 661
+ LA++ K L E + L++E + LQ + D LAD QL +++ E K
Sbjct: 864 DELAKSEAKRKEL-EEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKI 922
Query: 662 VHL------EEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
+ EE+I+A L+A K++L LK D + L T+ +E K NK++N
Sbjct: 923 KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKQKHATENKVKNLT 982
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ---FGIDAKIQER-DLYIENIESE 770
+E L + + K+S EK + L + + + +Q + I K + + + ++++E
Sbjct: 983 EEMAGLDETIAKLSKEK--KALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGS 1040
Query: 771 LSKYKSRICRLEESIAVME-DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
L + K LE + +E D + + E D +KQ+ + +E E+ N ++
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDM----ENDKQQLDEKLEKKEFEISNLISK 1096
Query: 830 LMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL---VEKA 883
+ D V ++K++ E++ +EL ++ + + SD+ + + +E+A
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1156
Query: 884 NRTDLAESE-STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRD 942
A+ E + K + + + L +L+ T +H+ ++ +K+ D E QI++ R
Sbjct: 1157 GGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRV 1216
Query: 943 KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPD 1002
K +K EK ++L+ + + +N E ++ L KM L D+ V +T+ +
Sbjct: 1217 K----QKLEKE---KSELKMETDDLSSNAEAISKAKGHLEKMCRSLEDQ-VSGLKTKEEE 1268
Query: 1003 YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
++ IN++ A L+ + E +++++ Q + +S +S + Q +L++ E
Sbjct: 1269 -QQRLINDLTAQRARLQTEAGE---YSRQLDE-QDALVSQLSRSKQASTQQIEELKHQLE 1323
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
E + L + Q + L+RE Q +E +E K + + K + + +
Sbjct: 1324 EETKAKNALAHALQSSRHDCDLLRE---QYEEEQEGKAELQRALSKANSEVAQWRTKYET 1380
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEE-EFIQER-SVLQEQSAKLNTELQECYTKI----I 1176
D + L+ EE E + + + L++ +L E+++ +
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA 1440
Query: 1177 QLETLNTELTGHDVVNQE---QINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ--- 1230
L+ + D V E + + +++LE E+ +L + + ++++ ++DQ
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLET 1500
Query: 1231 --RGFEIAELWKQHLAQREADFQKTEHEL---RVQLSAFESKYEQLLDSVQSSTQEETNK 1285
R + + L ++ A+ K HEL + Q+ + + + L+ ++S + E K
Sbjct: 1501 LRRAHKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGK 1560
Query: 1286 IVTME----QVTS-LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
I+ ++ QV S + K+ +K+E + L+ + V +E ++S + D ++
Sbjct: 1561 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRV---VETMQSTL-DAEIRSRNDALR 1616
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
++ + ++ +S+ N LK++ D +
Sbjct: 1617 VKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ----EDLKE 1672
Query: 1401 KVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELA 1460
++ + + L +EI E TL Q + Q+L++ +R++ L + + + L
Sbjct: 1673 QLAIVERRANLLQAEI----EELWATLEQTERSRKIAEQELLDASERVQ-LLHTQNTSLI 1727
Query: 1461 ILRLKMHENANHYETMQKESEIERVKLIEELNV--KITESVSLNKQVAELNKALEEEVAK 1518
+ K+ EN + Q +SE+E V + E N K ++++ +AE K ++ A
Sbjct: 1728 NTKKKL-EN----DVSQLQSEVEEV-IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
M+ LE ++ DE L ++ +IQK
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQK 1817
Score = 101 bits (243), Expect = 2e-20
Identities = 198/992 (19%), Positives = 414/992 (41%), Gaps = 72/992 (7%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ +++ L +A LE E SLE
Sbjct: 983 EEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLE 1042
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++S +K +++EK + ++ L KIE
Sbjct: 1043 QEKKLRMDLERAKRKLEGDLK----LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIE 1098
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ + Q+++ KEL+ ++ +G E +A ++ S + K + + +++ +L
Sbjct: 1099 DEQAVEIQLQKKIKELQARIEELGEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1153
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
++NK A+ + + + L + + E +++ G+ I
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL-RKKHADSMAELGEQ--I 1210
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE 509
LQ Q+ + S + + T+D++ A+ + K L + +++D + LK+ E
Sbjct: 1211 DNLQRVKQKLEKEKSELKM--ETDDLSSNAEAISKAKGHLEKMCR--SLEDQVSGLKTKE 1266
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
E+ +L +++ A + + +L + + S++S S + + EEL H
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEQDALV---SQLSRSKQASTQQIEELKH--- 1320
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAISLLESQ--KFDL 626
+LEEE S R + D+ ++ E E + L +A+S S+ ++
Sbjct: 1321 ---QLEEETKAKNALAHALQSSRH-DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1376
Query: 627 VQELHILQ--QKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELALVIE 683
E +Q ++ +E + KLA Q + V K LE+ L ++L L +E
Sbjct: 1377 KYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436
Query: 684 N-----LKLDKEQ--LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS--AEKISE 734
LDK+Q + + + E+ +L+ +E+ L+ +L K+ E+ +
Sbjct: 1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L + ++ Q + +I E I +E + + C ++ A +E+ S
Sbjct: 1497 QLETLRRAHKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQ---AALEEAEAS 1553
Query: 795 LERKADQLGSYLQEKQKAYSEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL 851
LE + ++ E + SE ++DE +++L +H RVVE ++ E+
Sbjct: 1554 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHTRVVETMQSTLD---AEI 1608
Query: 852 QKKNQILLEENQNLQISLSDMQ---QHYNALVEKANRTDLAESESTKYQTQLRDLESNLK 908
+ +N L + ++ L++M+ H N L ++ R + ++ +TQL ++
Sbjct: 1609 RSRND-ALRVKKKMEGDLNEMEIQLNHANRLAAESLR-NYRNTQGILKETQLHLDDALRG 1666
Query: 909 RITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + Q IV+++ + EI E +E R +K+ ++ E V L Q
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
N + L +V +L E+I + ++ T+ + L K++D
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAM----MAEELKKEQDTSAHL 1782
Query: 1028 LNQKINNAQ-VSYMSMVSDYESKLAQFTTK--LENMEEEMQRVSKQLLDSKQHNEELQIL 1084
K N Q V + D +LA K ++ +E ++ + ++ + ++ N E
Sbjct: 1783 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG 1842
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
+R+ D ++KEL N+ + + ++ + S + K+
Sbjct: 1843 LRKHDRRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKL 1902
Query: 1145 QEEEEFIQERS-VLQEQSAKLNTELQECYTKI 1175
Q E E +ER+ + + Q KL + +E +TKI
Sbjct: 1903 QHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 92.7 bits (220), Expect = 1e-17
Identities = 151/764 (19%), Positives = 318/764 (41%), Gaps = 48/764 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + + + +L + E + KEL++K LL+E +LQ+ +Q +
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQSEAD 899
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+L + R + + + +++++ + E + KK+++ED E I+
Sbjct: 900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEE-EEEINAELTAKKRKLEDECSELKKDID 958
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV +K+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 959 DLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEED 1018
Query: 995 KQQ--TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T++ EQ ++++ K+ ++ +K+ D E+ Q
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KLE E E+ + ++ D + +LQ ++E +I+EL E + K E
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Query: 1113 --IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ L + E EF + R L+E A L E
Sbjct: 1139 RSDLSRELEEISERLEE----AGGATSAQVELNKKREAEFQKLRRDLEE--ATLQHEAMV 1192
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ +++ EL G + N +++ Q L+ + +L E D+ LS+ AE S ++
Sbjct: 1193 AALRKKHADSM-AEL-GEQIDNLQRVKQKLEKEKSELKMETDD-LSSNAEAISKAKGHLE 1249
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHEL---RVQLSAFESKYEQLLDSVQS-STQEETNK 1285
+ + E L +E + Q+ ++L R +L +Y + LD + +Q +K
Sbjct: 1250 KMCRSL-EDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEQDALVSQLSRSK 1308
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ +Q+ L+++L+++ + L + ++LR + E+E+
Sbjct: 1309 QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ--------EGKAEL 1360
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN-AKCASLEK 1419
Query: 1406 THQL---ELKDSEI-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES---E 1458
T Q E++D + ++++ L ++ F+ V L E++++ E+ E E+ E
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKV---LSEWKQKYEETQAELEASQKE 1476
Query: 1459 LAILRLKMHENANHYETMQKESEIER--VKLIEELNVKITESVSL-NKQVAELNKALEEE 1515
L ++ + N YE + E R K +++ +TE ++ KQ+ EL K ++
Sbjct: 1477 SRSLSTELFKVKNVYEESLDQLETLRRAHKNLQQEISDLTEQIAEGGKQIHELEKIKKQV 1536
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1537 EQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1580
Score = 89.8 bits (213), Expect = 7e-17
Identities = 197/1125 (17%), Positives = 457/1125 (40%), Gaps = 87/1125 (7%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 906 ERCEQLIKNKIQLEAKIK-EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK-KINKNEIA 408
A + + A + K L +G + S + ET Q D + ++++
Sbjct: 965 AKVEKQKHATENKVKN---LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN 1021
Query: 409 KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
L L + + D E + ++ D A+ +LE + S + +
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLR---------MDLERAKRKLEGDLKLAQESTMDM 1072
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD--LIEKLKSAEEQITQLNDEIDAANKNM 526
+ + ++E + +E L +I+D + L +K+K + +I +L +EI+A +
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K + +++++ + + + V L ++ QK+ + E+ LQ H
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR-DLEEATLQ-HEA 1190
Query: 587 DYDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ R +D ++ E ++NL + K LE +K +L E L + +
Sbjct: 1191 MVAALRKKHADSMAELGEQIDNLQRVKQK----LEKEKSELKMETDDLSSNAEAISKAKG 1246
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
+ +++C LE+Q+ L ++E +I +L + +L + ++
Sbjct: 1247 HL-----EKMCRS-----LEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE 1296
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q+ + + + ++ S ++I EL ++ E ++K + + + DL E
Sbjct: 1297 -----QDALVSQL---SRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE 1348
Query: 766 NIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
E E + K+ + R L ++ + + R E A Q L+E +K ++ + +E V
Sbjct: 1349 QYEEE-QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHV 1407
Query: 825 NRL-AVLMDHDRVVEKQLLEIEHENKELQKKN---QILLEENQNLQISLSDMQQHYNALV 880
+ A ++ ++ E+E ++++ N L ++ +N LS+ +Q Y
Sbjct: 1408 EAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE--- 1464
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAI 940
E + ++ ES T+L +++ + + +TL ++ ++L+ E + E
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL----RRAHKNLQQEISDLTEQIA 1520
Query: 941 RDKKVLN--EKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
K ++ EK +K +E +++A L+E + ++E+ + + ++ L + V ++
Sbjct: 1521 EGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKI 1579
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ + +Q LK+ ++ Q +A++ + + K+ L
Sbjct: 1580 AEKDEEIDQ-----------LKRNHTRVVETMQSTLDAEIRSRNDALRVKKKM---EGDL 1625
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQ----DDQIK---ELKETKLTFE--MNIPK 1108
ME ++ ++ +S ++ Q +++E DD ++ +LKE E N+ +
Sbjct: 1626 NEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
E + +T+E ++ + + L + I + L+ ++L +E+
Sbjct: 1686 AEIEELWATLE-QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV 1744
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+E + E + + E++ + + L NL TV +L+ + A
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA- 1803
Query: 1229 DQRGFEIAELWKQHLAQREADFQ-KTEHELRVQLSAFES--KYEQLLDSVQSSTQEETNK 1285
+Q + + Q L R + + + E+E + A + K+++ + + T+E+
Sbjct: 1804 EQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHDRRVKELTYQTEEDRKN 1863
Query: 1286 IVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
++ ++ V LQ K++ + +E+ +++ L+ E+E+
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEE 1908
>BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 124 bits (299), Expect = 3e-27
Identities = 221/1105 (20%), Positives = 467/1105 (42%), Gaps = 98/1105 (8%)
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+++ KD E+L +E+ T++ E++ + ++ + +Q+Q + F++ +
Sbjct: 852 EELQAKD--EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 554 NKEIV----RLTEELHHLSQKVAELEE-------EKGNLQLHLVDYDSGRMIESDVYKKM 602
+ L E LH L +V E EE EK +Q H+ D + ++ E + ++
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE-QLDEEEGARQK 968
Query: 603 IEMENL-AETRLK----AISLLESQKFDLVQELHILQQKYDEVEDKLAD----ISQLQSD 653
+++E + AE ++K I LLE Q ++E +++ + E +LA+ L
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI---MNKL 710
+ E+ LEE++ +++EL L + L I +L+ +++ + K
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 711 QNYIQENMDLTD--KLEKMSAEK-ISELLAKINH-EEQSKIQTQFGIDAKIQERDLYIEN 766
+ +Q + D L K +A K + EL A+I +E + + A+ Q+RDL
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL---- 1144
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL K+ + ++ A ++ R E++ +L L+E+ K + Q ++ R
Sbjct: 1145 -SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK---NHEAQIQDMRQR 1200
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
A ++ + +QL + + L+K Q L +N+ L + +QQ K +
Sbjct: 1201 HATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 887 D-------LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
D SE + + +L + S L+ TL+ + +K+ + +ES
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD-AASLESQ 1316
Query: 940 IRD-KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
++D +++L E+ + + +++ QL+E KN+++ EE K NLE +Q Q
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIR-QLEEEKNSLQEQQEEEEEARK-NLEKQVLALQSQLA 1374
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + I L K+ ++ AL+Q++ ++Y + +++L Q L
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-DKLEKTKNRLQQELDDL- 1432
Query: 1059 NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISST 1117
++ + QR L+ KQ + Q+L E+ + +E + E +T+ + ++
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEE------EFIQERSVLQEQSAKLNTELQEC 1171
+E + + L +++ E + + L++Q ++ T+L+E
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
++ E L + + Q + L+++ EQ + L+ V EL + + Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 1231 RGFEIAELWKQHL------AQREA------DFQKTEHELRVQLSAFESKYEQL---LDSV 1275
R +A K + AQ EA + K +L+ Q+ ++ + E+ D +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 1276 QSSTQEETNKIVTME-QVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ ++E K+ ++E ++ LQ +L E H +++ AD I +S + DEK
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
++ N +++ Q + +N E A + ++
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-VDTLNAELAAERSAAQKSDNARQQL 1790
Query: 1392 XXRVNDAEAKVLELTHQLELK----DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKR 1447
+ + +AK+ EL ++ K S + K + L Q E + + EK+
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQK-ESEIERVK-LIEELNVKITE-SVSLNKQ 1504
++++ + E E + H + + E M+K + ++++K +EE + T + S K
Sbjct: 1851 LKEIFMQVEDE------RRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 1505 VAELNKALEEEVAKTNEMQTALENQ 1529
EL+ A E + E+ T L+N+
Sbjct: 1904 QRELDDATEANEGLSREVST-LKNR 1927
Score = 124 bits (298), Expect = 4e-27
Identities = 181/985 (18%), Positives = 421/985 (42%), Gaps = 69/985 (7%)
Query: 595 ESDVYKKMIEMENLAETRLKA---ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQ 651
E ++ K E+ + E + K + +E + L++E +IL ++ + A+ +++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
+ K LEE + L + +E + L+ +K+++ I+DLE ++ Q
Sbjct: 911 ARLAA---KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 712 NYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
E + K++KM E + + +K E++ +++ E + +N+
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK 1027
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
+K + I LEE + E R LE+ +L + Q +E Q DEL +LA
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA- 1086
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ E Q +++ L K N L+ + LQ ++++Q+ + + EKA+R A
Sbjct: 1087 ----KKEEELQGALARGDDETLHKNNA--LKVVRELQAQIAELQEDFES--EKASRNK-A 1137
Query: 890 ESESTKYQTQLRDLESNLKRI---THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
E + +L L++ L+ T Q L ++++E+ +L+ + ++ + +
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+++ +E +++ Q + +K N+E +E NK L K +Q+ + +S ++
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKK 1256
Query: 1007 YINEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
++ +L+A + + D E+ K+ N + +++ + E K +F ++E +
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +R+ +++ L+E + E E +++ + ++D
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ-LAD 1375
Query: 1124 DANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETL 1181
VD K + ++ E + +R E+ A +L++ ++ Q L+ L
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTKNRLQQELDDL 1432
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV---DQRGFEIAEL 1238
+L H + + + K +QL E ++ + AE R + + + +A
Sbjct: 1433 TVDLD-HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
++ L +E +F++ +LR + S + + +V + E +K +QV ++ +
Sbjct: 1492 LEEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH---ELEKSKRALEQQVEEMRTQ 1547
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
L++ E+ L+ ++ + ++ ++++ E + +L E +
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1359 YKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
++ + ++ + + LK N A +V++ +L+ + + YQ
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAA--------NKARDEVIKQLRKLQAQMKD-YQ 1658
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
+ L + + + Q E EK+++ L E+E+ L++ E E ++
Sbjct: 1659 RE------LEEARASRDEIFAQSKESEKKLKSL----EAEI----LQLQEELASSERARR 1704
Query: 1479 ESEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
+E ER +L +E+ + + E L ++A+L + LEEE + + +
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQK 1556
++ TLN E+ ++ + S + Q+
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQ 1789
Score = 120 bits (288), Expect = 6e-26
Identities = 186/1039 (17%), Positives = 440/1039 (42%), Gaps = 73/1039 (7%)
Query: 445 KDTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K+ L QLQ E + E + + +++ EI E +E +E ++ +++ +
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKK 946
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
K+++ + + + DE + A + + K + K+K+M++ I + D N + ++
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI---LLLEDQNSKFIKEKKL 1003
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
+ + + S ++AE EE+ NL + ++ SD+ +++ + E + KA L
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIR---NKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKEL 678
+ + DL ++ LQ + DE++ +LA + LQ + +++H + + + ++
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT---DKLEKMSAEKISEL 735
A + E+ + +K K + D + + L+ +++ +D T +L ++++EL
Sbjct: 1121 AELQEDFESEKASRNKAEKQ-KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 736 LAKI-----NHEEQSKIQTQFGIDA------KIQERDLYIENIESELSKYKSRICRLEES 784
+ NHE Q + Q A ++++ + N+E ++ L
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ V++ + E K +L + +QE SE EL + + L + V L E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E + + K L + Q+ Q L + + L + + + ++ + Q + +
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA----IRDKKVLNEKYEKNIEYVTQL 960
NL++ Q+ + KK+++D ++ +E A ++D + L+++ E+ +L
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDD-DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 961 EAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
E + +++L ++++ ++ NLE K + + + +Y E ++ A
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK---QLLDSK 1075
++K+ + ++L + + A + ++E + Q +E++ V K +L SK
Sbjct: 1479 REKETKALSLARALEEA----LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 1076 ----QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
Q EE++ + E +D+++ ++ KL E+N+ + M + + D N +
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM---QAMKAQFERDLQTRDEQN-EEK 1590
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
L+ + E+E ++R++ K+ +L++ +I E+
Sbjct: 1591 KRLLIKQVRELEAELEDE-RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
Q Q+ + +LE+ D + + E + S EI +L ++ LA E +
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL----EAEILQL-QEELASSERARR 1704
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
E E R +L+ +++ +S + K ++ L+ +L++++ ++ L +
Sbjct: 1705 HAEQE-RDELA------DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 1312 KYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ----SYKQMQEQSI 1367
++ Q++ L +E+ E+ A +L+ + Q + K + +I
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSA-AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ + QL++ V E K+ E+ Q+E + + +Y +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE----DERRHADQYKEQM 1872
Query: 1428 TQRNDEFENVRQQLVEYEK 1446
+ N + +++QL E E+
Sbjct: 1873 EKANARMKQLKRQLEEAEE 1891
Score = 119 bits (287), Expect = 8e-26
Identities = 211/1064 (19%), Positives = 447/1064 (42%), Gaps = 86/1064 (8%)
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
Q+T+ +E+ A ++ ++KVK + K++ + ++ + K I L E+L ++
Sbjct: 846 QVTRQEEELQAKDEELLKVKEK-QTKVEGELEEMERKHQQLLEEKNI--LAEQLQAETEL 902
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
AE EE + L + ++ + + ++E+ E + +L+++K + +
Sbjct: 903 FAEAEEMRARLAAK----------KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
L+++ DE E +LQ ++V +E K +EE+I L + I+ KL ++
Sbjct: 953 QDLEEQLDEEEGAR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKF---IKEKKLMED 1006
Query: 691 QLYGTIKDLENDKEDIMN--KLQNYIQENM--DLTDKLEKMSAEKISELLAKINHE---E 743
++ L ++E N K++N QE M DL ++L+K EK + L K + E
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNK-QEVMISDLEERLKK--EEKTRQELEKAKRKLDGE 1063
Query: 744 QSKIQTQFG-IDAKIQERDLYI----ENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q + A+I E L + E ++ L++ ++ V+ + + +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEKQLLEIEHENKELQKKNQI 857
+ S + KA + +EL L D D +Q L + E +E+ + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-QEVAELKKA 1182
Query: 858 LLEENQNLQISLSDM-QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
L EE +N + + DM Q+H AL E + + + A+ + + LE++ K + E +
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L Q K E E + + Q++ L+ K + +L + + +N ++N++
Sbjct: 1243 L-QQVKAESEHKRKKLDAQVQE-------LHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+EE K ++ K ++Q D T++ + E + L + ++ + Q
Sbjct: 1295 LLEEAEKKGIKFA-KDAASLESQLQD-TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ E ++ ++L + + ++V L + E + L+++ + + L+
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTK---KKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
E L ++ + KT+ + + D + ++ EE+ I R
Sbjct: 1410 EKALAYD-KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR-- 1466
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E+ + E +E TK + L E + Q QL++ +E L + D++
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH---ELRVQLSAFESKYEQLLD 1273
V EL S A++Q+ E + L + E + Q TE L V + A ++++E+ D
Sbjct: 1527 VHELEKS-KRALEQQ----VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--D 1579
Query: 1274 SVQSSTQEETNKIVTMEQVTSLQNKLQD--KEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
Q E K + ++QV L+ +L+D K+ L +K ++ ++ L ++IE
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI--DLKDLEAQIEAAN 1637
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
A L+ + + Y++ E++ + +E AQ K+S
Sbjct: 1638 KA--------RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
+ + H + +D E+ + + DE + ++ + E+ +E
Sbjct: 1690 LQLQEELASSERARRHAEQERD-ELADEITNSASGKSALLDEKRRLEARIAQLEEELE-- 1746
Query: 1452 TYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
E++S + +L + + +T+ E ER + N + L +Q EL
Sbjct: 1747 --EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR----QQLERQNKELKAK 1800
Query: 1512 LEE-EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
L+E E A ++ + + E +I L +++ + RA+++K+
Sbjct: 1801 LQELEGAVKSKFKATISALEAKIGQLEEQLEQ-EAKERAAANKL 1843
Score = 115 bits (276), Expect = 2e-24
Identities = 163/851 (19%), Positives = 349/851 (41%), Gaps = 67/851 (7%)
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQEKQKAYSEYTI 818
L + E EL + +++E +E +ERK QL + L E+ +A +E
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+ +E+ RLA +E+ L ++E +E +++NQIL E + +Q + D+++ +
Sbjct: 905 EAEEMRARLAAKKQE---LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
E+ R L + E + +++ +E + + + + +++KK +ED E ++Q+
Sbjct: 962 --EEGARQKL-QLEKVTAEAKIKKMEEEIL-LLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
K L + K ++ LE +L++ + + L +L+ +L D+ + + Q
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ-IAELQA 1076
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQK---INNAQVSYMSMVSDYESKLA---Q 1052
Q + Q + +L L + D+E + N + Q + D+ES+ A +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK-----ETKLTFEMNIP 1107
+ ++ EE++ + +L D+ Q L +++ ++ ELK ETK E I
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-NHEAQIQ 1195
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA----- 1162
++ +E +S+ L+ + +E E VLQ+ A
Sbjct: 1196 DMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLET-DNKELACEVKVLQQVKAESEHK 1253
Query: 1163 --KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
KL+ ++QE + K+ + + L EL Q +++ + + LE+ + A L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
S + + E + K +L+ R ++ ++ L+ Q E + L
Sbjct: 1314 ESQLQDTQELLQEETRQ--KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL--------- 1362
Query: 1281 EETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
E + Q+ + K+ D + +L+E ++ E L +E++ +A+
Sbjct: 1363 -EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQ---EQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
DL + +Q+ E+ ++ A+ K S +
Sbjct: 1422 KNRLQQELD-DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 1398 AEAKVLELTHQLE--LKDSEIYQKTHEYTIT-----LTQRNDEFENVRQQLVEYEKRIED 1450
E K L L LE L+ E +++ ++ ++ ++D +NV + L + ++ +E
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQ 1539
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS----LNKQVA 1506
E ++L L ++ + ++ + + + +L + ++ L KQV
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 1507 ELNKALEEE-------VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
EL LE+E VA +M+ L++ E +I N + +R ++++ +
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1560 FASDTKQGRDE 1570
+ + RDE
Sbjct: 1660 ELEEARASRDE 1670
Score = 109 bits (261), Expect = 1e-22
Identities = 197/1012 (19%), Positives = 433/1012 (42%), Gaps = 102/1012 (10%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H L + ++E++ +LQ + K M+ I DL+E+++E++ K +
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG-ARQKLQLEKVTAE 977
Query: 199 XXXXXXXXXXXXXEDTKQQM---TKMQENFIA----MEAEWKDEKQRLLKDIESKDVRIS 251
ED + K+ E+ IA AE +++ + L K ++V IS
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LEE K E R E+ KL E L Q K E E
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL------AKKEEE 1091
Query: 312 EKGSLEIANMTELTKK--IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL 369
+G+L + L K ++++ L QI + ++ E++ A+ K S++
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE---- 1147
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS 429
+K+ T Q + + E+A+L+ ++L ++ + E I
Sbjct: 1148 ---------LEALKTELEDTLDTTAAQQELRTKREQEVAELK---KALEEETKNHEAQIQ 1195
Query: 430 EKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL 489
+ + + + +++ +G + T+ +++ KV +Q+K E
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQG-----LETDNKELACEVKVLQQVKAES 1250
Query: 490 NDEIK--DVNVKDLIEKLKSAE-------EQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
+ K D V++L K+ + E+ ++L +E+D + +++ +K +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS-TLLEEAEKKGIKFAKD 1309
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDV- 598
+++ S++ D+ + + T + +LS ++ +LEEEK +LQ + + R +E V
Sbjct: 1310 AASLE--SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 599 --YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE---VEDKLADI-SQLQS 652
++ + + + L I LE K L+++ L Q+ +E DKL ++LQ
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 653 D------------QVCSEIKSVHLEEQIDALSASKKELA--LVIENLKLDKEQLYGTIK- 697
+ QV S ++ +++ D L A +K ++ E + + E K
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEK--KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 698 -DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK 756
L E+ + + + ++N L +E + + K ++ ++ E+SK ++ +
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSK-DDVGKNVHELEKSK----RALEQQ 1540
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVME---DRRYSLERKADQLGSYLQEKQKAY 813
++E +E +E EL + RLE ++ M+ +R + ++ L KQ
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E ++++ LAV + +E L ++E + + K ++++ + LQ + D Q
Sbjct: 1601 LEAELEDERKQRALAVA--SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ +A+R ++ ++S + + +L+ LE+ + ++ E + ++ E E
Sbjct: 1659 RELEE--ARASRDEIF-AQSKESEKKLKSLEAEILQL-QEELASSERARRHAEQERDELA 1714
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN----MNVEELNKMNLELI 989
+I ++ K L ++ + + QLE +L+E ++N+E LN +++ +N EL
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 990 DKHVQKQQTQSPDYTEQYINEINK-LNALLKQKDEEIIA-LNQKIN--NAQVSYMSMVSD 1045
++ Q D Q + NK L A L++ + + + I+ A++ + +
Sbjct: 1775 ---AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 1046 YESKLAQFTTKL-ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
E+K KL E++++ + Q+ D ++H ++ + + + + ++K+LK
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Score = 100 bits (240), Expect = 4e-20
Identities = 200/1006 (19%), Positives = 424/1006 (42%), Gaps = 76/1006 (7%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKN-KATTXXXXXXXX 202
VT ++ KD L ++ K +E +L+E + Q++E KN A
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEG---ELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESK-DVRISSLEEANKLLE 261
K+Q + + + E ++E+ ++L++ + K I LEE E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 262 AARFEISLE----HSKLAQELEQ--XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS 315
AR ++ LE +K+ + E+ L + I + E EEK
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 316 --LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
+I N E+ I LE + +T +ELE + E+ + + I
Sbjct: 1024 NLAKIRNKQEV--MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID-- 1079
Query: 374 SGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDT 433
++ +L L + D+ ++KN K+ +Q+ +L +E SEK +
Sbjct: 1080 ---ELKLQLAKKEEELQG-ALARGDDETLHKNNALKVVRELQAQIAEL--QEDFESEKAS 1133
Query: 434 XXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI 493
+ L A L+ E + ++ + T+ E+A++++ L++E +
Sbjct: 1134 RNKAEKQKRDLSEELEA-LKTELEDTLD-TTAAQQELRTKREQEVAELKKALEEETKNH- 1190
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SD 552
+ ++D+ ++ +A E++++ ++ N+ K K + K++ + +V ++
Sbjct: 1191 -EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI-EMENLAET 611
S + +L ++ L KV+E + L++ L + S E D ++ E E
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGD----RLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
K + LESQ D QEL LQ++ + + + I QL+ ++ + ++ EE+
Sbjct: 1306 FAKDAASLESQLQD-TQEL--LQEETRQKLNLSSRIRQLEEEK--NSLQEQQEEEEEARK 1360
Query: 672 SASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTDKLEK 726
+ K+ LAL + + K + GTI+ LE K+ ++ L ++E DKLEK
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ ++ + L + + + Q ++ K ++ D + +S ++Y R E
Sbjct: 1421 -TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVLMDHDRVVEK 839
E + SL R ++ +E ++ + ++L++ + L R +E+
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
Q+ E+ + +EL+ + Q + L++++ M+ + + R + E + Q
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--DLQTRDEQNEEKKRLLIKQ 1597
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R+LE+ L+ + + KKK DL+ + QIE+A N+ ++ I+ + +
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLK-DLEAQIEAA-------NKARDEVIKQLRK 1649
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
L+AQ+++Y+ +E + +E+ + E +K ++ + + E+ + +
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKE-SEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLE----NMEEEMQRVSKQLL 1072
++DE L +I N+ +++ + E+++AQ +LE NME R K L
Sbjct: 1709 ERDE----LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 1073 DSKQHNEEL---QILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
N EL + ++ D+ ++L+ + + + EG + S
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Score = 97.1 bits (231), Expect = 5e-19
Identities = 173/795 (21%), Positives = 333/795 (41%), Gaps = 94/795 (11%)
Query: 839 KQLLEIEHENKELQKKNQILL---EENQNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
K LL++ + +ELQ K++ LL E+ ++ L +M++ + L+E+ N LAE
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI--LAE----- 894
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
QL+ E+ L E + + KK+E+E++ + +++E ++L + +K
Sbjct: 895 ---QLQ-AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 956 YVTQLEAQLQEYKNNIENLNMN----VEELNKMNLELI------DKHVQKQQTQSPDYTE 1005
++ LE QL E + + L + ++ KM E++ K +++++ E
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 1006 ---QYINEINKLN--ALLKQKDEEIIA-LNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
Q E K A ++ K E +I+ L +++ + + + + KL TT L++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQD 1069
Query: 1060 MEEEMQ-RVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
E+Q ++ + L + EELQ L R D+ + + K+ E+ E +
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE---LQED 1126
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
E N + LK E E+ + + QE K E+ E K ++
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKT-ELEDTLDTTAAQQELRTKREQEVAE-LKKALE 1184
Query: 1178 LETLNTELTGHDVVNQ------------EQINQLKSKLEQ----LNTENDNLLSTVAELR 1221
ET N E D+ + EQ + K+ LE+ L T+N L V L+
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+ + +R A++ + H E D LRV+L+ SK + LD+V + +E
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGD------RLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 1282 ETNK-IVTMEQVTSLQNKLQDKEEHLR-------NLQEKYADVINQIEILRSEIEDEKVA 1333
K I + SL+++LQD +E L+ NL + + + L+ + E+E+ A
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 1334 -------FXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
DL T +S ++ +++ + + + +L++ +
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ + ++L HQ ++ S + +K ++ L E +++ + E
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVA-SNLEKKQKKFDQLLA----EEKSISARYAEERD 1472
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVA 1506
R E EKE++ L + E E +++++ R + E+L ++ + K V
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM-EDL---MSSKDDVGKNVH 1528
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
EL K+ + EM+T LE E E+ D L+ ++A ++ ++ + Q
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-------Q 1581
Query: 1567 GRDEQLDNTMNKELL 1581
RDEQ N K LL
Sbjct: 1582 TRDEQ--NEEKKRLL 1594
Score = 51.2 bits (117), Expect = 3e-05
Identities = 105/596 (17%), Positives = 253/596 (42%), Gaps = 39/596 (6%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E++ A L+ ++ +++ + D ++K+++ IE+ +A
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---- 1408
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
E+ K+++ ++ E D L D++ + S+LE+ K + E
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDD----LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL-TKKIEL 330
++ A+E ++ LA+ ++E + E K E E + A+M +L + K ++
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
++++ ++ ++ + LE ++ M T+ + + + R A K + +
Sbjct: 1524 GKNVH-ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLV-----DKEYVISEKDTXXXXXXXXXXGK 445
+ N++ + + K ++ +LE ++ K K+ I KD +
Sbjct: 1583 RDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA-R 1640
Query: 446 DTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
D +I QL+ L+ Q L + +++ +K E+ + L EI + ++L
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ-EELASS 1699
Query: 505 LKS---AEEQITQLNDEI--DAANKN-MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++ AE++ +L DEI A+ K+ ++ K + ++ Q+++ ++ SN E++
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE----EQSNMELL 1755
Query: 559 --RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA- 615
R + + AEL E+ Q ++ K+ E+E +++ KA
Sbjct: 1756 NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDA 670
IS LE++ L ++L + K +KL ++ + ++ +++ +EQ++
Sbjct: 1816 ISALEAKIGQLEEQLE-QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 671 LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
+A K+L +E + + + + + L+ + +D + +E L ++L +
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 45.2 bits (102), Expect = 0.002
Identities = 62/312 (19%), Positives = 132/312 (42%), Gaps = 19/312 (6%)
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED--EKVAFXXXXXXXX 1342
K+ + QVT + +LQ K+E L ++EK V ++E + + + E+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
++R + KQ E+ + ++ + ++ + + D E ++
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 1403 LE-----LTHQLELKDSEI-YQKTHEYTITLTQRNDEF----ENVRQQLVEYEKRIEDLT 1452
E QLE +E +K E + L +N +F + + ++ E ++ +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE-E 1018
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
EK LA +R K + E K+ E R +L + E+ L Q+AEL +
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 1513 EE---EVA-KTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+E ++A K E+Q AL + E + N+ + ++ + +A +++Q+ + + +
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAELQEDFE-SEKASRNK 1136
Query: 1569 DEQLDNTMNKEL 1580
E+ +++EL
Sbjct: 1137 AEKQKRDLSEEL 1148
>BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 124 bits (299), Expect = 3e-27
Identities = 221/1105 (20%), Positives = 467/1105 (42%), Gaps = 98/1105 (8%)
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+++ KD E+L +E+ T++ E++ + ++ + +Q+Q + F++ +
Sbjct: 852 EELQAKD--EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 554 NKEIV----RLTEELHHLSQKVAELEE-------EKGNLQLHLVDYDSGRMIESDVYKKM 602
+ L E LH L +V E EE EK +Q H+ D + ++ E + ++
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE-QLDEEEGARQK 968
Query: 603 IEMENL-AETRLK----AISLLESQKFDLVQELHILQQKYDEVEDKLAD----ISQLQSD 653
+++E + AE ++K I LLE Q ++E +++ + E +LA+ L
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI---MNKL 710
+ E+ LEE++ +++EL L + L I +L+ +++ + K
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 711 QNYIQENMDLTD--KLEKMSAEK-ISELLAKINH-EEQSKIQTQFGIDAKIQERDLYIEN 766
+ +Q + D L K +A K + EL A+I +E + + A+ Q+RDL
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL---- 1144
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL K+ + ++ A ++ R E++ +L L+E+ K + Q ++ R
Sbjct: 1145 -SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK---NHEAQIQDMRQR 1200
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
A ++ + +QL + + L+K Q L +N+ L + +QQ K +
Sbjct: 1201 HATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 887 D-------LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
D SE + + +L + S L+ TL+ + +K+ + +ES
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD-AASLESQ 1316
Query: 940 IRD-KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
++D +++L E+ + + +++ QL+E KN+++ EE K NLE +Q Q
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIR-QLEEEKNSLQEQQEEEEEARK-NLEKQVLALQSQLA 1374
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + I L K+ ++ AL+Q++ ++Y + +++L Q L
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-DKLEKTKNRLQQEPDDL- 1432
Query: 1059 NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISST 1117
++ + QR L+ KQ + Q+L E+ + +E + E +T+ + ++
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEE------EFIQERSVLQEQSAKLNTELQEC 1171
+E + + L +++ E + + L++Q ++ T+L+E
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
++ E L + + Q + L+++ EQ + L+ V EL + + Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 1231 RGFEIAELWKQHL------AQREA------DFQKTEHELRVQLSAFESKYEQL---LDSV 1275
R +A K + AQ EA + K +L+ Q+ ++ + E+ D +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 1276 QSSTQEETNKIVTME-QVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ ++E K+ ++E ++ LQ +L E H +++ AD I +S + DEK
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
++ N +++ Q + +N E A + ++
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-VDTLNAELAAERSAAQKSDNARQQL 1790
Query: 1392 XXRVNDAEAKVLELTHQLELK----DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKR 1447
+ + +AK+ EL ++ K S + K + L Q E + + EK+
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQK-ESEIERVK-LIEELNVKITE-SVSLNKQ 1504
++++ + E E + H + + E M+K + ++++K +EE + T + S K
Sbjct: 1851 LKEIFMQVEDE------RRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 1505 VAELNKALEEEVAKTNEMQTALENQ 1529
EL+ A E + E+ T L+N+
Sbjct: 1904 QRELDDATEANEGLSREVST-LKNR 1927
Score = 121 bits (291), Expect = 2e-26
Identities = 179/984 (18%), Positives = 417/984 (42%), Gaps = 67/984 (6%)
Query: 595 ESDVYKKMIEMENLAETRLKA---ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQ 651
E ++ K E+ + E + K + +E + L++E +IL ++ + A+ +++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
+ K LEE + L + +E + L+ +K+++ I+DLE ++ Q
Sbjct: 911 ARLAA---KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 712 NYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
E + K++KM E + + +K E++ +++ E + +N+
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK 1027
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
+K + I LEE + E R LE+ +L + Q +E Q DEL +LA
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA- 1086
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ E Q +++ L K N L+ + LQ ++++Q+ + + EKA+R A
Sbjct: 1087 ----KKEEELQGALARGDDETLHKNNA--LKVVRELQAQIAELQEDFES--EKASRNK-A 1137
Query: 890 ESESTKYQTQLRDLESNLKRI---THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
E + +L L++ L+ T Q L ++++E+ +L+ + ++ + +
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+++ +E +++ Q + +K N+E +E NK L K +Q+ + +S ++
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKK 1256
Query: 1007 YINEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
++ +L+A + + D E+ K+ N + +++ + E K +F ++E +
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +R+ +++ L+E + E E +++ + ++D
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ-LAD 1375
Query: 1124 DANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLN 1182
VD K + ++ E + +R E+ A +L++ ++ Q
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTKNRLQQEPDDL 1432
Query: 1183 TELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV---DQRGFEIAELW 1239
T H + + + K +QL E ++ + AE R + + + +A
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 1240 KQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKL 1299
++ L +E +F++ +LR + S + + +V + E +K +QV ++ +L
Sbjct: 1493 EEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH---ELEKSKRALEQQVEEMRTQL 1548
Query: 1300 QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
++ E+ L+ ++ + ++ ++++ E + +L E +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
++ + ++ + + LK N A +V++ +L+ + + YQ+
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAA--------NKARDEVIKQLRKLQAQMKD-YQR 1659
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
L + + + Q E EK+++ L E+E+ L++ E E ++
Sbjct: 1660 E------LEEARASRDEIFAQSKESEKKLKSL----EAEI----LQLQEELASSERARRH 1705
Query: 1480 SEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
+E ER +L +E+ + + E L ++A+L + LEEE + + ++
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 1533 IVTLNDEITNLQNMVRASSSKIQK 1556
+ TLN E+ ++ + S + Q+
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQ 1789
Score = 120 bits (288), Expect = 6e-26
Identities = 219/1076 (20%), Positives = 454/1076 (42%), Gaps = 110/1076 (10%)
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
Q+T+ +E+ A ++ ++KVK + K++ + ++ + K I L E+L ++
Sbjct: 846 QVTRQEEELQAKDEELLKVKEK-QTKVEGELEEMERKHQQLLEEKNI--LAEQLQAETEL 902
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
AE EE + L + ++ + + ++E+ E + +L+++K + +
Sbjct: 903 FAEAEEMRARLAAK----------KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
L+++ DE E +LQ ++V +E K +EE+I L + I+ KL ++
Sbjct: 953 QDLEEQLDEEEGAR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKF---IKEKKLMED 1006
Query: 691 QLYGTIKDLENDKEDIMN--KLQNYIQENM--DLTDKLEKMSAEKISELLAKINHE---E 743
++ L ++E N K++N QE M DL ++L+K EK + L K + E
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNK-QEVMISDLEERLKK--EEKTRQELEKAKRKLDGE 1063
Query: 744 QSKIQTQFG-IDAKIQERDLYI----ENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q + A+I E L + E ++ L++ ++ V+ + + +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEKQLLEIEHENKELQKKNQI 857
+ S + KA + +EL L D D +Q L + E +E+ + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-QEVAELKKA 1182
Query: 858 LLEENQNLQISLSDM-QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
L EE +N + + DM Q+H AL E + + + A+ + + LE++ K + E +
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L Q K E E + + Q++ L+ K + +L + + +N ++N++
Sbjct: 1243 L-QQVKAESEHKRKKLDAQVQE-------LHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 977 NVEELNKMNLEL------IDKHVQKQQTQSPDYTEQYINEINKLNAL------LKQKDEE 1024
+EE K ++ ++ +Q Q + T Q +N +++ L L+++ EE
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ + ++ S ++D + K+ +E++EE +++ K Q EE
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE---- 1410
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
K L KL N + E ++ ++ A+N++ ++
Sbjct: 1411 --------KALAYDKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFD------QL 1456
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
EE+ I R E+ + E +E TK + L E + Q QL++ +E
Sbjct: 1457 LAEEKSISAR--YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH---ELRVQL 1261
L + D++ V EL S A++Q+ E + L + E + Q TE L V +
Sbjct: 1515 DLMSSKDDVGKNVHELEKS-KRALEQQ----VEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 1262 SAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD--KEEHLRNLQEKYADVINQ 1319
A ++++E+ D Q E K + ++QV L+ +L+D K+ L +K ++
Sbjct: 1570 QAMKAQFER--DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI--D 1625
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
++ L ++IE A L+ + + Y++ E++ + +E AQ K+
Sbjct: 1626 LKDLEAQIEAANKA--------RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 1380 SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQ 1439
S + + H + +D E+ + + DE +
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERD-ELADEITNSASGKSALLDEKRRLEA 1736
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
++ + E+ +E E++S + +L + + +T+ E ER + N +
Sbjct: 1737 RIAQLEEELE----EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR----Q 1788
Query: 1500 SLNKQVAELNKALEE-EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
L +Q EL L+E E A ++ + + E +I L +++ + RA+++K+
Sbjct: 1789 QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ-EAKERAAANKL 1843
Score = 118 bits (283), Expect = 2e-25
Identities = 186/1039 (17%), Positives = 439/1039 (42%), Gaps = 73/1039 (7%)
Query: 445 KDTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K+ L QLQ E + E + + +++ EI E +E +E ++ +++ +
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKK 946
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
K+++ + + + DE + A + + K + K+K+M++ I + D N + ++
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI---LLLEDQNSKFIKEKKL 1003
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
+ + + S ++AE EE+ NL + ++ SD+ +++ + E + KA L
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIR---NKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKEL 678
+ + DL ++ LQ + DE++ +LA + LQ + +++H + + + ++
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT---DKLEKMSAEKISEL 735
A + E+ + +K K + D + + L+ +++ +D T +L ++++EL
Sbjct: 1121 AELQEDFESEKASRNKAEKQ-KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 736 LAKI-----NHEEQSKIQTQFGIDA------KIQERDLYIENIESELSKYKSRICRLEES 784
+ NHE Q + Q A ++++ + N+E ++ L
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ V++ + E K +L + +QE SE EL + + L + V L E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E + + K L + Q+ Q L + + L + + + ++ + Q + +
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA----IRDKKVLNEKYEKNIEYVTQL 960
NL++ Q+ + KK+++D ++ +E A ++D + L+++ E+ +L
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDD-DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 961 EAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
E + ++L ++++ ++ NLE K + + + +Y E ++ A
Sbjct: 1419 EKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK---QLLDSK 1075
++K+ + ++L + + A + ++E + Q +E++ V K +L SK
Sbjct: 1479 REKETKALSLARALEEA----LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 1076 ----QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
Q EE++ + E +D+++ ++ KL E+N+ + M + + D N +
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM---QAMKAQFERDLQTRDEQN-EEK 1590
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
L+ + E+E ++R++ K+ +L++ +I E+
Sbjct: 1591 KRLLIKQVRELEAELEDE-RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
Q Q+ + +LE+ D + + E + S EI +L ++ LA E +
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL----EAEILQL-QEELASSERARR 1704
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
E E R +L+ +++ +S + K ++ L+ +L++++ ++ L +
Sbjct: 1705 HAEQE-RDELA------DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 1312 KYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ----SYKQMQEQSI 1367
++ Q++ L +E+ E+ A +L+ + Q + K + +I
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSA-AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ + QL++ V E K+ E+ Q+E + + +Y +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE----DERRHADQYKEQM 1872
Query: 1428 TQRNDEFENVRQQLVEYEK 1446
+ N + +++QL E E+
Sbjct: 1873 EKANARMKQLKRQLEEAEE 1891
Score = 114 bits (275), Expect = 2e-24
Identities = 163/851 (19%), Positives = 349/851 (41%), Gaps = 67/851 (7%)
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQEKQKAYSEYTI 818
L + E EL + +++E +E +ERK QL + L E+ +A +E
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+ +E+ RLA +E+ L ++E +E +++NQIL E + +Q + D+++ +
Sbjct: 905 EAEEMRARLAAKKQE---LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
E+ R L + E + +++ +E + + + + +++KK +ED E ++Q+
Sbjct: 962 --EEGARQKL-QLEKVTAEAKIKKMEEEIL-LLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
K L + K ++ LE +L++ + + L +L+ +L D+ + + Q
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ-IAELQA 1076
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQK---INNAQVSYMSMVSDYESKLA---Q 1052
Q + Q + +L L + D+E + N + Q + D+ES+ A +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK-----ETKLTFEMNIP 1107
+ ++ EE++ + +L D+ Q L +++ ++ ELK ETK E I
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-NHEAQIQ 1195
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA----- 1162
++ +E +S+ L+ + +E E VLQ+ A
Sbjct: 1196 DMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLET-DNKELACEVKVLQQVKAESEHK 1253
Query: 1163 --KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
KL+ ++QE + K+ + + L EL Q +++ + + LE+ + A L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
S + + E + K +L+ R ++ ++ L+ Q E + L
Sbjct: 1314 ESQLQDTQELLQEETRQ--KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL--------- 1362
Query: 1281 EETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
E + Q+ + K+ D + +L+E ++ E L +E++ +A+
Sbjct: 1363 -EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQ---EQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
DL + +Q+ E+ ++ A+ K S +
Sbjct: 1422 KNRLQQEPD-DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 1398 AEAKVLELTHQLE--LKDSEIYQKTHEYTIT-----LTQRNDEFENVRQQLVEYEKRIED 1450
E K L L LE L+ E +++ ++ ++ ++D +NV + L + ++ +E
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQ 1539
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS----LNKQVA 1506
E ++L L ++ + ++ + + + +L + ++ L KQV
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 1507 ELNKALEEE-------VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
EL LE+E VA +M+ L++ E +I N + +R ++++ +
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1560 FASDTKQGRDE 1570
+ + RDE
Sbjct: 1660 ELEEARASRDE 1670
Score = 109 bits (262), Expect = 8e-23
Identities = 196/1012 (19%), Positives = 431/1012 (42%), Gaps = 102/1012 (10%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H L + ++E++ +LQ + K M+ I DL+E+++E++ K +
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG-ARQKLQLEKVTAE 977
Query: 199 XXXXXXXXXXXXXEDTKQQM---TKMQENFIA----MEAEWKDEKQRLLKDIESKDVRIS 251
ED + K+ E+ IA AE +++ + L K ++V IS
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LEE K E R E+ KL E L Q K E E
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL------AKKEEE 1091
Query: 312 EKGSLEIANMTELTKK--IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL 369
+G+L + L K ++++ L QI + ++ E++ A+ K S++
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE---- 1147
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS 429
+K+ T Q + + E+A+L+ ++L ++ + E I
Sbjct: 1148 ---------LEALKTELEDTLDTTAAQQELRTKREQEVAELK---KALEEETKNHEAQIQ 1195
Query: 430 EKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL 489
+ + + + +++ +G + T+ +++ KV +Q+K E
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQG-----LETDNKELACEVKVLQQVKAES 1250
Query: 490 NDEIK--DVNVKDLIEKLKSAE-------EQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
+ K D V++L K+ + E+ ++L +E+D + +++ +K +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS-TLLEEAEKKGIKFAKD 1309
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDV- 598
+++ S++ D+ + + T + +LS ++ +LEEEK +LQ + + R +E V
Sbjct: 1310 AASLE--SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 599 --YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQK-------YDEVEDKLADISQ 649
++ + + + L I LE K L+++ L Q+ YD++E + Q
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 650 LQSD---------QVCSEIKSVHLEEQIDALSASKKELA--LVIENLKLDKEQLYGTIK- 697
D QV S ++ +++ D L A +K ++ E + + E K
Sbjct: 1428 EPDDLTVDLDHQRQVASNLEK--KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 698 -DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK 756
L E+ + + + ++N L +E + + K ++ ++ E+SK ++ +
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSK-DDVGKNVHELEKSK----RALEQQ 1540
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVME---DRRYSLERKADQLGSYLQEKQKAY 813
++E +E +E EL + RLE ++ M+ +R + ++ L KQ
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E ++++ LAV + +E L ++E + + K ++++ + LQ + D Q
Sbjct: 1601 LEAELEDERKQRALAVA--SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ +A+R ++ ++S + + +L+ LE+ + ++ E + ++ E E
Sbjct: 1659 RELEE--ARASRDEIF-AQSKESEKKLKSLEAEILQL-QEELASSERARRHAEQERDELA 1714
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN----MNVEELNKMNLELI 989
+I ++ K L ++ + + QLE +L+E ++N+E LN +++ +N EL
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 990 DKHVQKQQTQSPDYTEQYINEINK-LNALLKQKDEEIIA-LNQKIN--NAQVSYMSMVSD 1045
++ Q D Q + NK L A L++ + + + I+ A++ + +
Sbjct: 1775 ---AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 1046 YESKLAQFTTKL-ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
E+K KL E++++ + Q+ D ++H ++ + + + + ++K+LK
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Score = 98.7 bits (235), Expect = 2e-19
Identities = 201/1009 (19%), Positives = 424/1009 (42%), Gaps = 82/1009 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKN-KATTXXXXXXXX 202
VT ++ KD L ++ K +E +L+E + Q++E KN A
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEG---ELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESK-DVRISSLEEANKLLE 261
K+Q + + + E ++E+ ++L++ + K I LEE E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 262 AARFEISLE----HSKLAQELEQ--XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS 315
AR ++ LE +K+ + E+ L + I + E EEK
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 316 --LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
+I N E+ I LE + +T +ELE + E+ + + I
Sbjct: 1024 NLAKIRNKQEV--MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID-- 1079
Query: 374 SGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDT 433
++ +L L + D+ ++KN K+ +Q+ +L +E SEK +
Sbjct: 1080 ---ELKLQLAKKEEELQG-ALARGDDETLHKNNALKVVRELQAQIAEL--QEDFESEKAS 1133
Query: 434 XXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI 493
+ L A L+ E + ++ + T+ E+A++++ L++E +
Sbjct: 1134 RNKAEKQKRDLSEELEA-LKTELEDTLD-TTAAQQELRTKREQEVAELKKALEEETKNH- 1190
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SD 552
+ ++D+ ++ +A E++++ ++ N+ K K + K++ + +V ++
Sbjct: 1191 -EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI-EMENLAET 611
S + +L ++ L KV+E + L++ L + S E D ++ E E
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGD----RLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
K + LESQ D QEL LQ++ + + + I QL+ ++ + ++ EE+
Sbjct: 1306 FAKDAASLESQLQD-TQEL--LQEETRQKLNLSSRIRQLEEEK--NSLQEQQEEEEEARK 1360
Query: 672 SASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTDKLEK 726
+ K+ LAL + + K + GTI+ LE K+ ++ L ++E DKLEK
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420
Query: 727 MS---AEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE 783
++ +L ++H+ Q ++ K ++ D + +S ++Y R E
Sbjct: 1421 TKNRLQQEPDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVLMDHDRV 836
E + SL R ++ +E ++ + ++L++ + L R
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
+E+Q+ E+ + +EL+ + Q + L++++ M+ + + R + E +
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--DLQTRDEQNEEKKRLL 1594
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
Q+R+LE+ L+ + + KKK DL+ + QIE+A N+ ++ I+
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLK-DLEAQIEAA-------NKARDEVIKQ 1646
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ +L+AQ+++Y+ +E + +E+ + E +K ++ + + E+ +
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKE-SEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLE----NMEEEMQRVSK 1069
+++DE L +I N+ +++ + E+++AQ +LE NME R K
Sbjct: 1706 AEQERDE----LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761
Query: 1070 QLLDSKQHNEEL---QILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
L N EL + ++ D+ ++L+ + + + EG + S
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Score = 97.1 bits (231), Expect = 5e-19
Identities = 173/795 (21%), Positives = 333/795 (41%), Gaps = 94/795 (11%)
Query: 839 KQLLEIEHENKELQKKNQILL---EENQNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
K LL++ + +ELQ K++ LL E+ ++ L +M++ + L+E+ N LAE
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI--LAE----- 894
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
QL+ E+ L E + + KK+E+E++ + +++E ++L + +K
Sbjct: 895 ---QLQ-AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 956 YVTQLEAQLQEYKNNIENLNMN----VEELNKMNLELI------DKHVQKQQTQSPDYTE 1005
++ LE QL E + + L + ++ KM E++ K +++++ E
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 1006 ---QYINEINKLN--ALLKQKDEEIIA-LNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
Q E K A ++ K E +I+ L +++ + + + + KL TT L++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQD 1069
Query: 1060 MEEEMQ-RVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
E+Q ++ + L + EELQ L R D+ + + K+ E+ E +
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE---LQED 1126
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
E N + LK E E+ + + QE K E+ E K ++
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKT-ELEDTLDTTAAQQELRTKREQEVAE-LKKALE 1184
Query: 1178 LETLNTELTGHDVVNQ------------EQINQLKSKLEQ----LNTENDNLLSTVAELR 1221
ET N E D+ + EQ + K+ LE+ L T+N L V L+
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+ + +R A++ + H E D LRV+L+ SK + LD+V + +E
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGD------RLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 1282 ETNK-IVTMEQVTSLQNKLQDKEEHLR-------NLQEKYADVINQIEILRSEIEDEKVA 1333
K I + SL+++LQD +E L+ NL + + + L+ + E+E+ A
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 1334 -------FXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
DL T +S ++ +++ + + + +L++ +
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ + ++L HQ ++ S + +K ++ L E +++ + E
Sbjct: 1418 LEKTKNRLQQEPDDLTVDLDHQRQVA-SNLEKKQKKFDQLLA----EEKSISARYAEERD 1472
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVA 1506
R E EKE++ L + E E +++++ R + E+L ++ + K V
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM-EDL---MSSKDDVGKNVH 1528
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
EL K+ + EM+T LE E E+ D L+ ++A ++ ++ + Q
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-------Q 1581
Query: 1567 GRDEQLDNTMNKELL 1581
RDEQ N K LL
Sbjct: 1582 TRDEQ--NEEKKRLL 1594
Score = 50.4 bits (115), Expect = 5e-05
Identities = 105/596 (17%), Positives = 253/596 (42%), Gaps = 39/596 (6%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E++ A L+ ++ +++ + D ++K+++ IE+ +A
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---- 1408
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
E+ K+++ ++ E D L D++ + S+LE+ K + E
Sbjct: 1409 EEKALAYDKLEKTKNRLQQEPDD----LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL-TKKIEL 330
++ A+E ++ LA+ ++E + E K E E + A+M +L + K ++
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
++++ ++ ++ + LE ++ M T+ + + + R A K + +
Sbjct: 1524 GKNVH-ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLV-----DKEYVISEKDTXXXXXXXXXXGK 445
+ N++ + + K ++ +LE ++ K K+ I KD +
Sbjct: 1583 RDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA-R 1640
Query: 446 DTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
D +I QL+ L+ Q L + +++ +K E+ + L EI + ++L
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ-EELASS 1699
Query: 505 LKS---AEEQITQLNDEI--DAANKN-MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++ AE++ +L DEI A+ K+ ++ K + ++ Q+++ ++ SN E++
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE----EQSNMELL 1755
Query: 559 --RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA- 615
R + + AEL E+ Q ++ K+ E+E +++ KA
Sbjct: 1756 NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDA 670
IS LE++ L ++L + K +KL ++ + ++ +++ +EQ++
Sbjct: 1816 ISALEAKIGQLEEQLE-QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 671 LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
+A K+L +E + + + + + L+ + +D + +E L ++L +
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 45.2 bits (102), Expect = 0.002
Identities = 62/312 (19%), Positives = 132/312 (42%), Gaps = 19/312 (6%)
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED--EKVAFXXXXXXXX 1342
K+ + QVT + +LQ K+E L ++EK V ++E + + + E+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
++R + KQ E+ + ++ + ++ + + D E ++
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 1403 LE-----LTHQLELKDSEI-YQKTHEYTITLTQRNDEF----ENVRQQLVEYEKRIEDLT 1452
E QLE +E +K E + L +N +F + + ++ E ++ +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE-E 1018
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
EK LA +R K + E K+ E R +L + E+ L Q+AEL +
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 1513 EE---EVA-KTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+E ++A K E+Q AL + E + N+ + ++ + +A +++Q+ + + +
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAELQEDFE-SEKASRNK 1136
Query: 1569 DEQLDNTMNKEL 1580
E+ +++EL
Sbjct: 1137 AEKQKRDLSEEL 1148
>AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein
protein.
Length = 2018
Score = 124 bits (299), Expect = 3e-27
Identities = 221/1105 (20%), Positives = 467/1105 (42%), Gaps = 98/1105 (8%)
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+++ KD E+L +E+ T++ E++ + ++ + +Q+Q + F++ +
Sbjct: 894 EELQAKD--EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 951
Query: 554 NKEIV----RLTEELHHLSQKVAELEE-------EKGNLQLHLVDYDSGRMIESDVYKKM 602
+ L E LH L +V E EE EK +Q H+ D + ++ E + ++
Sbjct: 952 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE-QLDEEEGARQK 1010
Query: 603 IEMENL-AETRLK----AISLLESQKFDLVQELHILQQKYDEVEDKLAD----ISQLQSD 653
+++E + AE ++K I LLE Q ++E +++ + E +LA+ L
Sbjct: 1011 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1070
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI---MNKL 710
+ E+ LEE++ +++EL L + L I +L+ +++ + K
Sbjct: 1071 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1130
Query: 711 QNYIQENMDLTD--KLEKMSAEK-ISELLAKINH-EEQSKIQTQFGIDAKIQERDLYIEN 766
+ +Q + D L K +A K + EL A+I +E + + A+ Q+RDL
Sbjct: 1131 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL---- 1186
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
EL K+ + ++ A ++ R E++ +L L+E+ K + Q ++ R
Sbjct: 1187 -SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK---NHEAQIQDMRQR 1242
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
A ++ + +QL + + L+K Q L +N+ L + +QQ K +
Sbjct: 1243 HATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1299
Query: 887 D-------LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
D SE + + +L + S L+ TL+ + +K+ + +ES
Sbjct: 1300 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD-AASLESQ 1358
Query: 940 IRD-KKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
++D +++L E+ + + +++ QL+E KN+++ EE K NLE +Q Q
Sbjct: 1359 LQDTQELLQEETRQKLNLSSRIR-QLEEEKNSLQEQQEEEEEARK-NLEKQVLALQSQLA 1416
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + I L K+ ++ AL+Q++ ++Y + +++L Q L
Sbjct: 1417 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-DKLEKTKNRLQQELDDL- 1474
Query: 1059 NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISST 1117
++ + QR L+ KQ + Q+L E+ + +E + E +T+ + ++
Sbjct: 1475 TVDLDHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1533
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEE------EFIQERSVLQEQSAKLNTELQEC 1171
+E + + L +++ E + + L++Q ++ T+L+E
Sbjct: 1534 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1593
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
++ E L + + Q + L+++ EQ + L+ V EL + + Q
Sbjct: 1594 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1653
Query: 1231 RGFEIAELWKQHL------AQREA------DFQKTEHELRVQLSAFESKYEQL---LDSV 1275
R +A K + AQ EA + K +L+ Q+ ++ + E+ D +
Sbjct: 1654 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1713
Query: 1276 QSSTQEETNKIVTME-QVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ ++E K+ ++E ++ LQ +L E H +++ AD I +S + DEK
Sbjct: 1714 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1773
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
++ N +++ Q + +N E A + ++
Sbjct: 1774 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-VDTLNAELAAERSAAQKSDNARQQL 1832
Query: 1392 XXRVNDAEAKVLELTHQLELK----DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKR 1447
+ + +AK+ EL ++ K S + K + L Q E + + EK+
Sbjct: 1833 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1892
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQK-ESEIERVK-LIEELNVKITE-SVSLNKQ 1504
++++ + E E + H + + E M+K + ++++K +EE + T + S K
Sbjct: 1893 LKEIFMQVEDE------RRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1945
Query: 1505 VAELNKALEEEVAKTNEMQTALENQ 1529
EL+ A E + E+ T L+N+
Sbjct: 1946 QRELDDATEANEGLSREVST-LKNR 1969
Score = 124 bits (298), Expect = 4e-27
Identities = 181/985 (18%), Positives = 421/985 (42%), Gaps = 69/985 (7%)
Query: 595 ESDVYKKMIEMENLAETRLKA---ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQ 651
E ++ K E+ + E + K + +E + L++E +IL ++ + A+ +++
Sbjct: 893 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 952
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
+ K LEE + L + +E + L+ +K+++ I+DLE ++ Q
Sbjct: 953 ARLAA---KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 1009
Query: 712 NYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
E + K++KM E + + +K E++ +++ E + +N+
Sbjct: 1010 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK 1069
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
+K + I LEE + E R LE+ +L + Q +E Q DEL +LA
Sbjct: 1070 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA- 1128
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ E Q +++ L K N L+ + LQ ++++Q+ + + EKA+R A
Sbjct: 1129 ----KKEEELQGALARGDDETLHKNNA--LKVVRELQAQIAELQEDFES--EKASRNK-A 1179
Query: 890 ESESTKYQTQLRDLESNLKRI---THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
E + +L L++ L+ T Q L ++++E+ +L+ + ++ + +
Sbjct: 1180 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1239
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+++ +E +++ Q + +K N+E +E NK L K +Q+ + +S ++
Sbjct: 1240 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKK 1298
Query: 1007 YINEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
++ +L+A + + D E+ K+ N + +++ + E K +F ++E +
Sbjct: 1299 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1358
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +R+ +++ L+E + E E +++ + ++D
Sbjct: 1359 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ-LAD 1417
Query: 1124 DANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETL 1181
VD K + ++ E + +R E+ A +L++ ++ Q L+ L
Sbjct: 1418 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTKNRLQQELDDL 1474
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV---DQRGFEIAEL 1238
+L H + + + K +QL E ++ + AE R + + + +A
Sbjct: 1475 TVDLD-HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1533
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
++ L +E +F++ +LR + S + + +V + E +K +QV ++ +
Sbjct: 1534 LEEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH---ELEKSKRALEQQVEEMRTQ 1589
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
L++ E+ L+ ++ + ++ ++++ E + +L E +
Sbjct: 1590 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1649
Query: 1359 YKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
++ + ++ + + LK N A +V++ +L+ + + YQ
Sbjct: 1650 ERKQRALAVASKKKMEIDLKDLEAQIEAA--------NKARDEVIKQLRKLQAQMKD-YQ 1700
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
+ L + + + Q E EK+++ L E+E+ L++ E E ++
Sbjct: 1701 RE------LEEARASRDEIFAQSKESEKKLKSL----EAEI----LQLQEELASSERARR 1746
Query: 1479 ESEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
+E ER +L +E+ + + E L ++A+L + LEEE + + +
Sbjct: 1747 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1806
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQK 1556
++ TLN E+ ++ + S + Q+
Sbjct: 1807 QVDTLNAELAAERSAAQKSDNARQQ 1831
Score = 120 bits (288), Expect = 6e-26
Identities = 186/1039 (17%), Positives = 440/1039 (42%), Gaps = 73/1039 (7%)
Query: 445 KDTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K+ L QLQ E + E + + +++ EI E +E +E ++ +++ +
Sbjct: 931 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKK 988
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
K+++ + + + DE + A + + K + K+K+M++ I + D N + ++
Sbjct: 989 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI---LLLEDQNSKFIKEKKL 1045
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
+ + + S ++AE EE+ NL + ++ SD+ +++ + E + KA L
Sbjct: 1046 MEDRIAECSSQLAEEEEKAKNLAKIR---NKQEVMISDLEERLKKEEKTRQELEKAKRKL 1102
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKEL 678
+ + DL ++ LQ + DE++ +LA + LQ + +++H + + + ++
Sbjct: 1103 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1162
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT---DKLEKMSAEKISEL 735
A + E+ + +K K + D + + L+ +++ +D T +L ++++EL
Sbjct: 1163 AELQEDFESEKASRNKAEKQ-KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1221
Query: 736 LAKI-----NHEEQSKIQTQFGIDA------KIQERDLYIENIESELSKYKSRICRLEES 784
+ NHE Q + Q A ++++ + N+E ++ L
Sbjct: 1222 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1281
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ V++ + E K +L + +QE SE EL + + L + V L E
Sbjct: 1282 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1341
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E + + K L + Q+ Q L + + L + + + ++ + Q + +
Sbjct: 1342 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1401
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA----IRDKKVLNEKYEKNIEYVTQL 960
NL++ Q+ + KK+++D ++ +E A ++D + L+++ E+ +L
Sbjct: 1402 KNLEKQVLALQSQLADTKKKVDD-DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1460
Query: 961 EAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
E + +++L ++++ ++ NLE K + + + +Y E ++ A
Sbjct: 1461 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1520
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK---QLLDSK 1075
++K+ + ++L + + A + ++E + Q +E++ V K +L SK
Sbjct: 1521 REKETKALSLARALEEA----LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1576
Query: 1076 ----QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
Q EE++ + E +D+++ ++ KL E+N+ + M + + D N +
Sbjct: 1577 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM---QAMKAQFERDLQTRDEQN-EEK 1632
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
L+ + E+E ++R++ K+ +L++ +I E+
Sbjct: 1633 KRLLIKQVRELEAELEDE-RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1691
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
Q Q+ + +LE+ D + + E + S EI +L ++ LA E +
Sbjct: 1692 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL----EAEILQL-QEELASSERARR 1746
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
E E R +L+ +++ +S + K ++ L+ +L++++ ++ L +
Sbjct: 1747 HAEQE-RDELA------DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1799
Query: 1312 KYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ----SYKQMQEQSI 1367
++ Q++ L +E+ E+ A +L+ + Q + K + +I
Sbjct: 1800 RFRKTTLQVDTLNAELAAERSA-AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1858
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ + QL++ V E K+ E+ Q+E + + +Y +
Sbjct: 1859 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE----DERRHADQYKEQM 1914
Query: 1428 TQRNDEFENVRQQLVEYEK 1446
+ N + +++QL E E+
Sbjct: 1915 EKANARMKQLKRQLEEAEE 1933
Score = 119 bits (287), Expect = 8e-26
Identities = 211/1064 (19%), Positives = 447/1064 (42%), Gaps = 86/1064 (8%)
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
Q+T+ +E+ A ++ ++KVK + K++ + ++ + K I L E+L ++
Sbjct: 888 QVTRQEEELQAKDEELLKVKEK-QTKVEGELEEMERKHQQLLEEKNI--LAEQLQAETEL 944
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
AE EE + L + ++ + + ++E+ E + +L+++K + +
Sbjct: 945 FAEAEEMRARLAAK----------KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 994
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
L+++ DE E +LQ ++V +E K +EE+I L + I+ KL ++
Sbjct: 995 QDLEEQLDEEEGAR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKF---IKEKKLMED 1048
Query: 691 QLYGTIKDLENDKEDIMN--KLQNYIQENM--DLTDKLEKMSAEKISELLAKINHE---E 743
++ L ++E N K++N QE M DL ++L+K EK + L K + E
Sbjct: 1049 RIAECSSQLAEEEEKAKNLAKIRNK-QEVMISDLEERLKK--EEKTRQELEKAKRKLDGE 1105
Query: 744 QSKIQTQFG-IDAKIQERDLYI----ENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q + A+I E L + E ++ L++ ++ V+ + + +
Sbjct: 1106 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1165
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEKQLLEIEHENKELQKKNQI 857
+ S + KA + +EL L D D +Q L + E +E+ + +
Sbjct: 1166 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-QEVAELKKA 1224
Query: 858 LLEENQNLQISLSDM-QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
L EE +N + + DM Q+H AL E + + + A+ + + LE++ K + E +
Sbjct: 1225 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1284
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L Q K E E + + Q++ L+ K + +L + + +N ++N++
Sbjct: 1285 L-QQVKAESEHKRKKLDAQVQE-------LHAKVSEGDRLRVELAEKASKLQNELDNVST 1336
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+EE K ++ K ++Q D T++ + E + L + ++ + Q
Sbjct: 1337 LLEEAEKKGIKFA-KDAASLESQLQD-TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1394
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ E ++ ++L + + ++V L + E + L+++ + + L+
Sbjct: 1395 EEEEEARKNLEKQVLALQSQLADTK---KKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1451
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
E L ++ + KT+ + + D + ++ EE+ I R
Sbjct: 1452 EKALAYD-KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR-- 1508
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E+ + E +E TK + L E + Q QL++ +E L + D++
Sbjct: 1509 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1568
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH---ELRVQLSAFESKYEQLLD 1273
V EL S A++Q+ E + L + E + Q TE L V + A ++++E+ D
Sbjct: 1569 VHELEKS-KRALEQQ----VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--D 1621
Query: 1274 SVQSSTQEETNKIVTMEQVTSLQNKLQD--KEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
Q E K + ++QV L+ +L+D K+ L +K ++ ++ L ++IE
Sbjct: 1622 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI--DLKDLEAQIEAAN 1679
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
A L+ + + Y++ E++ + +E AQ K+S
Sbjct: 1680 KA--------RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1731
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
+ + H + +D E+ + + DE + ++ + E+ +E
Sbjct: 1732 LQLQEELASSERARRHAEQERD-ELADEITNSASGKSALLDEKRRLEARIAQLEEELE-- 1788
Query: 1452 TYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
E++S + +L + + +T+ E ER + N + L +Q EL
Sbjct: 1789 --EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR----QQLERQNKELKAK 1842
Query: 1512 LEE-EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
L+E E A ++ + + E +I L +++ + RA+++K+
Sbjct: 1843 LQELEGAVKSKFKATISALEAKIGQLEEQLEQ-EAKERAAANKL 1885
Score = 115 bits (276), Expect = 2e-24
Identities = 163/851 (19%), Positives = 349/851 (41%), Gaps = 67/851 (7%)
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL---GSYLQEKQKAYSEYTI 818
L + E EL + +++E +E +ERK QL + L E+ +A +E
Sbjct: 887 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 946
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+ +E+ RLA +E+ L ++E +E +++NQIL E + +Q + D+++ +
Sbjct: 947 EAEEMRARLAAKKQE---LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 1003
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
E+ R L + E + +++ +E + + + + +++KK +ED E ++Q+
Sbjct: 1004 --EEGARQKL-QLEKVTAEAKIKKMEEEIL-LLEDQNSKFIKEKKLMEDRIAECSSQLAE 1059
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
K L + K ++ LE +L++ + + L +L+ +L D+ + + Q
Sbjct: 1060 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ-IAELQA 1118
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQK---INNAQVSYMSMVSDYESKLA---Q 1052
Q + Q + +L L + D+E + N + Q + D+ES+ A +
Sbjct: 1119 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1178
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK-----ETKLTFEMNIP 1107
+ ++ EE++ + +L D+ Q L +++ ++ ELK ETK E I
Sbjct: 1179 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-NHEAQIQ 1237
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA----- 1162
++ +E +S+ L+ + +E E VLQ+ A
Sbjct: 1238 DMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLET-DNKELACEVKVLQQVKAESEHK 1295
Query: 1163 --KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
KL+ ++QE + K+ + + L EL Q +++ + + LE+ + A L
Sbjct: 1296 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1355
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
S + + E + K +L+ R ++ ++ L+ Q E + L
Sbjct: 1356 ESQLQDTQELLQEETRQ--KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL--------- 1404
Query: 1281 EETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
E + Q+ + K+ D + +L+E ++ E L +E++ +A+
Sbjct: 1405 -EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1463
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQ---EQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
DL + +Q+ E+ ++ A+ K S +
Sbjct: 1464 KNRLQQELD-DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1522
Query: 1398 AEAKVLELTHQLE--LKDSEIYQKTHEYTIT-----LTQRNDEFENVRQQLVEYEKRIED 1450
E K L L LE L+ E +++ ++ ++ ++D +NV + L + ++ +E
Sbjct: 1523 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQ 1581
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS----LNKQVA 1506
E ++L L ++ + ++ + + + +L + ++ L KQV
Sbjct: 1582 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1641
Query: 1507 ELNKALEEE-------VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
EL LE+E VA +M+ L++ E +I N + +R ++++ +
Sbjct: 1642 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1701
Query: 1560 FASDTKQGRDE 1570
+ + RDE
Sbjct: 1702 ELEEARASRDE 1712
Score = 109 bits (261), Expect = 1e-22
Identities = 197/1012 (19%), Positives = 433/1012 (42%), Gaps = 102/1012 (10%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H L + ++E++ +LQ + K M+ I DL+E+++E++ K +
Sbjct: 961 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG-ARQKLQLEKVTAE 1019
Query: 199 XXXXXXXXXXXXXEDTKQQM---TKMQENFIA----MEAEWKDEKQRLLKDIESKDVRIS 251
ED + K+ E+ IA AE +++ + L K ++V IS
Sbjct: 1020 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1079
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LEE K E R E+ KL E L Q K E E
Sbjct: 1080 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL------AKKEEE 1133
Query: 312 EKGSLEIANMTELTKK--IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPL 369
+G+L + L K ++++ L QI + ++ E++ A+ K S++
Sbjct: 1134 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE---- 1189
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS 429
+K+ T Q + + E+A+L+ ++L ++ + E I
Sbjct: 1190 ---------LEALKTELEDTLDTTAAQQELRTKREQEVAELK---KALEEETKNHEAQIQ 1237
Query: 430 EKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL 489
+ + + + +++ +G + T+ +++ KV +Q+K E
Sbjct: 1238 DMRQRHATALEELSEQLEQAKRFKANLEKNKQG-----LETDNKELACEVKVLQQVKAES 1292
Query: 490 NDEIK--DVNVKDLIEKLKSAE-------EQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
+ K D V++L K+ + E+ ++L +E+D + +++ +K +
Sbjct: 1293 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS-TLLEEAEKKGIKFAKD 1351
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDV- 598
+++ S++ D+ + + T + +LS ++ +LEEEK +LQ + + R +E V
Sbjct: 1352 AASLE--SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1409
Query: 599 --YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE---VEDKLADI-SQLQS 652
++ + + + L I LE K L+++ L Q+ +E DKL ++LQ
Sbjct: 1410 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1469
Query: 653 D------------QVCSEIKSVHLEEQIDALSASKKELA--LVIENLKLDKEQLYGTIK- 697
+ QV S ++ +++ D L A +K ++ E + + E K
Sbjct: 1470 ELDDLTVDLDHQRQVASNLEK--KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1527
Query: 698 -DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK 756
L E+ + + + ++N L +E + + K ++ ++ E+SK ++ +
Sbjct: 1528 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSK-DDVGKNVHELEKSK----RALEQQ 1582
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVME---DRRYSLERKADQLGSYLQEKQKAY 813
++E +E +E EL + RLE ++ M+ +R + ++ L KQ
Sbjct: 1583 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1642
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E ++++ LAV + +E L ++E + + K ++++ + LQ + D Q
Sbjct: 1643 LEAELEDERKQRALAVA--SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1700
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ +A+R ++ ++S + + +L+ LE+ + ++ E + ++ E E
Sbjct: 1701 RELEE--ARASRDEIF-AQSKESEKKLKSLEAEILQL-QEELASSERARRHAEQERDELA 1756
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN----MNVEELNKMNLELI 989
+I ++ K L ++ + + QLE +L+E ++N+E LN +++ +N EL
Sbjct: 1757 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1816
Query: 990 DKHVQKQQTQSPDYTEQYINEINK-LNALLKQKDEEIIA-LNQKIN--NAQVSYMSMVSD 1045
++ Q D Q + NK L A L++ + + + I+ A++ + +
Sbjct: 1817 ---AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1873
Query: 1046 YESKLAQFTTKL-ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
E+K KL E++++ + Q+ D ++H ++ + + + + ++K+LK
Sbjct: 1874 QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1925
Score = 100 bits (240), Expect = 4e-20
Identities = 200/1006 (19%), Positives = 424/1006 (42%), Gaps = 76/1006 (7%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKN-KATTXXXXXXXX 202
VT ++ KD L ++ K +E +L+E + Q++E KN A
Sbjct: 889 VTRQEEELQAKDEELLKVKEKQTKVEG---ELEEMERKHQQLLEEKNILAEQLQAETELF 945
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESK-DVRISSLEEANKLLE 261
K+Q + + + E ++E+ ++L++ + K I LEE E
Sbjct: 946 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 1005
Query: 262 AARFEISLE----HSKLAQELEQ--XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS 315
AR ++ LE +K+ + E+ L + I + E EEK
Sbjct: 1006 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1065
Query: 316 --LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
+I N E+ I LE + +T +ELE + E+ + + I
Sbjct: 1066 NLAKIRNKQEV--MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID-- 1121
Query: 374 SGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDT 433
++ +L L + D+ ++KN K+ +Q+ +L +E SEK +
Sbjct: 1122 ---ELKLQLAKKEEELQG-ALARGDDETLHKNNALKVVRELQAQIAEL--QEDFESEKAS 1175
Query: 434 XXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI 493
+ L A L+ E + ++ + T+ E+A++++ L++E +
Sbjct: 1176 RNKAEKQKRDLSEELEA-LKTELEDTLD-TTAAQQELRTKREQEVAELKKALEEETKNH- 1232
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SD 552
+ ++D+ ++ +A E++++ ++ N+ K K + K++ + +V ++
Sbjct: 1233 -EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1291
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI-EMENLAET 611
S + +L ++ L KV+E + L++ L + S E D ++ E E
Sbjct: 1292 SEHKRKKLDAQVQELHAKVSEGD----RLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1347
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
K + LESQ D QEL LQ++ + + + I QL+ ++ + ++ EE+
Sbjct: 1348 FAKDAASLESQLQD-TQEL--LQEETRQKLNLSSRIRQLEEEK--NSLQEQQEEEEEARK 1402
Query: 672 SASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIM---NKLQNYIQENMDLTDKLEK 726
+ K+ LAL + + K + GTI+ LE K+ ++ L ++E DKLEK
Sbjct: 1403 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1462
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ ++ + L + + + Q ++ K ++ D + +S ++Y R E
Sbjct: 1463 -TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1521
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVLMDHDRVVEK 839
E + SL R ++ +E ++ + ++L++ + L R +E+
Sbjct: 1522 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1581
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
Q+ E+ + +EL+ + Q + L++++ M+ + + R + E + Q
Sbjct: 1582 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER--DLQTRDEQNEEKKRLLIKQ 1639
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R+LE+ L+ + + KKK DL+ + QIE+A N+ ++ I+ + +
Sbjct: 1640 VRELEAELEDERKQRALAVASKKKMEIDLK-DLEAQIEAA-------NKARDEVIKQLRK 1691
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
L+AQ+++Y+ +E + +E+ + E +K ++ + + E+ + +
Sbjct: 1692 LQAQMKDYQRELEEARASRDEIFAQSKE-SEKKLKSLEAEILQLQEELASSERARRHAEQ 1750
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLE----NMEEEMQRVSKQLL 1072
++DE L +I N+ +++ + E+++AQ +LE NME R K L
Sbjct: 1751 ERDE----LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1806
Query: 1073 DSKQHNEEL---QILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
N EL + ++ D+ ++L+ + + + EG + S
Sbjct: 1807 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1852
Score = 97.1 bits (231), Expect = 5e-19
Identities = 173/795 (21%), Positives = 333/795 (41%), Gaps = 94/795 (11%)
Query: 839 KQLLEIEHENKELQKKNQILL---EENQNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
K LL++ + +ELQ K++ LL E+ ++ L +M++ + L+E+ N LAE
Sbjct: 884 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI--LAE----- 936
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
QL+ E+ L E + + KK+E+E++ + +++E ++L + +K
Sbjct: 937 ---QLQ-AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 992
Query: 956 YVTQLEAQLQEYKNNIENLNMN----VEELNKMNLELI------DKHVQKQQTQSPDYTE 1005
++ LE QL E + + L + ++ KM E++ K +++++ E
Sbjct: 993 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1052
Query: 1006 ---QYINEINKLN--ALLKQKDEEIIA-LNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
Q E K A ++ K E +I+ L +++ + + + + KL TT L++
Sbjct: 1053 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQD 1111
Query: 1060 MEEEMQ-RVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
E+Q ++ + L + EELQ L R D+ + + K+ E+ E +
Sbjct: 1112 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE---LQED 1168
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
E N + LK E E+ + + QE K E+ E K ++
Sbjct: 1169 FESEKASRNKAEKQKRDLSEELEALKT-ELEDTLDTTAAQQELRTKREQEVAE-LKKALE 1226
Query: 1178 LETLNTELTGHDVVNQ------------EQINQLKSKLEQ----LNTENDNLLSTVAELR 1221
ET N E D+ + EQ + K+ LE+ L T+N L V L+
Sbjct: 1227 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1286
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+ + +R A++ + H E D LRV+L+ SK + LD+V + +E
Sbjct: 1287 QVKAESEHKRKKLDAQVQELHAKVSEGD------RLRVELAEKASKLQNELDNVSTLLEE 1340
Query: 1282 ETNK-IVTMEQVTSLQNKLQDKEEHLR-------NLQEKYADVINQIEILRSEIEDEKVA 1333
K I + SL+++LQD +E L+ NL + + + L+ + E+E+ A
Sbjct: 1341 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1400
Query: 1334 -------FXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
DL T +S ++ +++ + + + +L++ +
Sbjct: 1401 RKNLEKQVLALQSQLADTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDK 1459
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ + ++L HQ ++ S + +K ++ L E +++ + E
Sbjct: 1460 LEKTKNRLQQELDDLTVDLDHQRQVA-SNLEKKQKKFDQLLA----EEKSISARYAEERD 1514
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVA 1506
R E EKE++ L + E E +++++ R + E+L ++ + K V
Sbjct: 1515 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM-EDL---MSSKDDVGKNVH 1570
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
EL K+ + EM+T LE E E+ D L+ ++A ++ ++ + Q
Sbjct: 1571 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-------Q 1623
Query: 1567 GRDEQLDNTMNKELL 1581
RDEQ N K LL
Sbjct: 1624 TRDEQ--NEEKKRLL 1636
Score = 51.2 bits (117), Expect = 3e-05
Identities = 105/596 (17%), Positives = 253/596 (42%), Gaps = 39/596 (6%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E++ A L+ ++ +++ + D ++K+++ IE+ +A
Sbjct: 1395 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL---- 1450
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
E+ K+++ ++ E D L D++ + S+LE+ K + E
Sbjct: 1451 EEKALAYDKLEKTKNRLQQELDD----LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1506
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL-TKKIEL 330
++ A+E ++ LA+ ++E + E K E E + A+M +L + K ++
Sbjct: 1507 ARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1565
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
++++ ++ ++ + LE ++ M T+ + + + R A K + +
Sbjct: 1566 GKNVH-ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1624
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLV-----DKEYVISEKDTXXXXXXXXXXGK 445
+ N++ + + K ++ +LE ++ K K+ I KD +
Sbjct: 1625 RDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA-R 1682
Query: 446 DTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
D +I QL+ L+ Q L + +++ +K E+ + L EI + ++L
Sbjct: 1683 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ-EELASS 1741
Query: 505 LKS---AEEQITQLNDEI--DAANKN-MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++ AE++ +L DEI A+ K+ ++ K + ++ Q+++ ++ SN E++
Sbjct: 1742 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE----EQSNMELL 1797
Query: 559 --RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA- 615
R + + AEL E+ Q ++ K+ E+E +++ KA
Sbjct: 1798 NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1857
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDA 670
IS LE++ L ++L + K +KL ++ + ++ +++ +EQ++
Sbjct: 1858 ISALEAKIGQLEEQLE-QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1916
Query: 671 LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
+A K+L +E + + + + + L+ + +D + +E L ++L +
Sbjct: 1917 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1972
Score = 45.2 bits (102), Expect = 0.002
Identities = 62/312 (19%), Positives = 132/312 (42%), Gaps = 19/312 (6%)
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED--EKVAFXXXXXXXX 1342
K+ + QVT + +LQ K+E L ++EK V ++E + + + E+
Sbjct: 882 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 941
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
++R + KQ E+ + ++ + ++ + + D E ++
Sbjct: 942 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 1001
Query: 1403 LE-----LTHQLELKDSEI-YQKTHEYTITLTQRNDEF----ENVRQQLVEYEKRIEDLT 1452
E QLE +E +K E + L +N +F + + ++ E ++ +
Sbjct: 1002 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE-E 1060
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
EK LA +R K + E K+ E R +L + E+ L Q+AEL +
Sbjct: 1061 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1120
Query: 1513 EE---EVA-KTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+E ++A K E+Q AL + E + N+ + ++ + +A +++Q+ + + +
Sbjct: 1121 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAELQEDFE-SEKASRNK 1178
Query: 1569 DEQLDNTMNKEL 1580
E+ +++EL
Sbjct: 1179 AEKQKRDLSEEL 1190
>X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (1151
AA) protein.
Length = 1151
Score = 122 bits (293), Expect = 1e-26
Identities = 229/1133 (20%), Positives = 465/1133 (41%), Gaps = 96/1133 (8%)
Query: 471 NTEDVNEIAKVQEQ---LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ E E+A ++E+ LK+ L E + K+L EK+ S ++ L ++ A N+
Sbjct: 58 SAEREKEMASMKEEFTRLKEAL--EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 115
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
+ +K I +KV + N+ + E L+ K +LE+E L+ D
Sbjct: 116 DAEERCDQLIKNK---IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKR---D 169
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 170 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL--- 226
Query: 648 SQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-------DL 699
Q + D+V + K+ V LE+Q+D L S ++ V +L+ K +L G +K DL
Sbjct: 227 -QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 285
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI-QTQFGIDAKIQ 758
ENDK+ + +L+ E L ++E A + L K E Q++I + + ++A+
Sbjct: 286 ENDKQQLEERLKKKDFELNALNARIEDEQA--LGSQLQKKLKELQARIEELEEELEAERT 343
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
R +E + S+LS+ I E + + +K + + Q+ ++ E T+
Sbjct: 344 AR-AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEATL 399
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
Q + A+ H + E+ + LQ+ Q L +E ++ L D+ +
Sbjct: 400 QHE--ATAAALRKKH----ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 453
Query: 879 LVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+++ KAN E + Q+ + S + L Q+ K L+ E N ++
Sbjct: 454 IIKAKAN----LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK----LQTE-NGELS 504
Query: 938 SAIRDKKVLNEKYEK-NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL-IDKHVQK 995
+ +K+ L + + + Y QLE ++ + ++ N L + + + +
Sbjct: 505 RQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYE 564
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFT 1054
++T++ ++ +++ N A + K E + I +++ A+ + + E +
Sbjct: 565 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 624
Query: 1055 TKLENMEEEMQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
K ++E+ R+ + ++D ++ N L ++Q + K L E K +E +
Sbjct: 625 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES----- 679
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
S +E +A ++ ++ E F +E LQE+ + L +L
Sbjct: 680 ----QSELESSQKEARSLSTELFKLKNAYEE-SLEHLETFKRENKNLQEEISDLTEQLGS 734
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
I +LE + +L + Q + + ++ LE + ++++ I + +
Sbjct: 735 SGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 794
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-EETNKIV-- 1287
+ E+ + + HL ++ + E R + A K + D + Q N++
Sbjct: 795 KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE 854
Query: 1288 TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
+QV SLQ+ L+D + L +L+E A V + +L++E+E+ +
Sbjct: 855 AQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 914
Query: 1341 XXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
L ++N S +++ ++++ +++++
Sbjct: 915 RKLADEELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA 974
Query: 1395 VNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKR 1447
+ DA EL + + E +K E TI L R DE E + ++QL + E R
Sbjct: 975 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1034
Query: 1448 IEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLN 1502
+ +L E E+E ++ ++ E T Q E + + + +++L K+ V
Sbjct: 1035 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAY 1094
Query: 1503 KQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ-NMVRASSSKI 1554
K+ AE EE A TN + E++ +I Q N +RA S I
Sbjct: 1095 KRQAE----EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1143
Score = 109 bits (263), Expect = 6e-23
Identities = 211/1077 (19%), Positives = 444/1077 (41%), Gaps = 97/1077 (9%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEELH-------HLSQKVAELEEEKGNLQL----- 583
K+K + K+ + +++ +E RL E L L +K+ L +EK +LQL
Sbjct: 51 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 110
Query: 584 --HLVDYDS--GRMIESDVY--KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
+L D + ++I++ + K+ EM E + + L ++K L E L++
Sbjct: 111 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 170
Query: 638 DEVEDKLADISQLQSDQVCSEIKSV-----HLEEQIDALSASKKEL----ALVIENLKLD 688
D++E LA + + + +++K++ L+E I L+ KK L +++L+ +
Sbjct: 171 DDLELTLAKVEK-EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 229
Query: 689 KEQLYGTIK---DLENDKEDIMNKLQNYIQENMDL---TDKLE---KMSAEKISELLAKI 739
++++ K LE +D+ L+ + MDL KLE K++ E I +L
Sbjct: 230 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 289
Query: 740 NHEEQSKIQTQF---GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
E+ + F ++A+I++ ++ +L + ++RI LEE + R +E
Sbjct: 290 QQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 349
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
+ L L+E SE ++E + + M+ R E Q + + E LQ +
Sbjct: 350 KLRSDLSRELEE----ISE-RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 404
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
++ S++++ + + L + E E ++++ +L D+ SN+++I
Sbjct: 405 AAALRKKHAD-SVAELGEQIDNLQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKAN 460
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L + + +ED E ++ E R L + K +L QL E + I L
Sbjct: 461 L-EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTR 519
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ LE + + ++++ + + + L +Q +EE A+
Sbjct: 520 G-KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE--------TEAK 570
Query: 1037 VSYMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
++S S++AQ+ TK E EE++ K+L Q EE V + +
Sbjct: 571 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKC 627
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
L++TK + I E +++ +E + A +D K Q+ EE
Sbjct: 628 SSLEKTKHRLQNEI---EDLMVD--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQS 681
Query: 1153 ERSVLQEQSAKLNTE---LQECYTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQ 1205
E Q+++ L+TE L+ Y + ++ LET E + ++ EQ+ + +
Sbjct: 682 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 741
Query: 1206 LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSA 1263
L L + EL+S++ A E ++ + L Q +A+ ++ E ++
Sbjct: 742 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 801
Query: 1264 FESKYEQLLDSVQSSTQEET-NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
+ + +++DS+Q+S ET ++ + ++ L + E L + A+ Q++
Sbjct: 802 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 861
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSX 1382
L+S ++D ++ R N +++E + Q ++S
Sbjct: 862 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE-----LRAVVEQTERSRK 916
Query: 1383 XXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
RV ++ L +Q + D+++ Q E + + + E ++ +
Sbjct: 917 LADEELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 976
Query: 1443 EYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERV------KLIEELNVKI- 1495
+ E+L E+++ + R+K + + + E E++ K +++L ++
Sbjct: 977 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1036
Query: 1496 ---TESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
E + K+ AE K + + + E+ E ++ L D + LQ V+A
Sbjct: 1037 ELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1093
Score = 106 bits (255), Expect = 6e-22
Identities = 204/966 (21%), Positives = 395/966 (40%), Gaps = 72/966 (7%)
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMN 708
Q QS V + ++ L E+ D+L + + + +LY IK L E
Sbjct: 5 QAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAER-EK 63
Query: 709 KLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE 768
++ + +E L + LEK A + EL K+ Q K Q + A E+D + E
Sbjct: 64 EMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDLQLQVQA---EQDNLADAEE 119
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
K++I +LE + M +R E +L + ++ + SE D+L LA
Sbjct: 120 RCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA 178
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
+ E ++ + E L + L +E + LQ + QQ + L + ++ +
Sbjct: 179 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA---HQQALDDLQAEEDKVNT 235
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
K + Q+ DLE +L++ L K+K DL++ I DK+ L E
Sbjct: 236 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT-QESIMDLENDKQQLEE 294
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+ +K + L A++++ + L ++EL + +E +++ ++ ++T
Sbjct: 295 RLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEELEEELEAERTARA------- 346
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
++ KL + L ++ EEI ++ A + M E++ + LE E +Q +
Sbjct: 347 -KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE--EATLQHEA 403
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV 1128
K+H + + L EQ D ++ +K+ KL E + K E ++S +E + N+
Sbjct: 404 TAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKLELDDVTSNMEQIIKAKANL 461
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTELQECYTKIIQLETLNTELT 1186
+ + + EE +RSV L Q AKL TE E ++ + E L ++LT
Sbjct: 462 EKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 518
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
+ +Q+ LK +LE+ + L + R +Q E +
Sbjct: 519 RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE---------TEA 569
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+A+ Q+ + +++ + +KYE D++Q + + E E L +LQ+ EE +
Sbjct: 570 KAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE-------EAKKKLAQRLQEAEEAV 620
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS 1366
+ K + + L++EIED V L + +++ ++ +
Sbjct: 621 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA--------LDKKQRNFDKILAEW 672
Query: 1367 ILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTIT 1426
E ++L +SS ++ +A + LE + ++ + ++ + T
Sbjct: 673 KQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 731
Query: 1427 LTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYE---- 1474
L E E VR+QL + ++ E E+ L ILR ++ N E
Sbjct: 732 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 791
Query: 1475 TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
+K+ E+E+ K L V + SL+ + N+AL + +M+ L EI++
Sbjct: 792 LAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK----KKMEGDLNEMEIQLS 846
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMY 1594
N Q V++ S ++ D + D+ +N E + + +AEL+
Sbjct: 847 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 906
Query: 1595 MLHQRD 1600
++ Q +
Sbjct: 907 VVEQTE 912
Score = 96.3 bits (229), Expect = 8e-19
Identities = 213/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 66 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 125
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 126 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 184
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 185 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 241
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QLE + +
Sbjct: 242 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLEERLKKK 299
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 300 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 359
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 360 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 419
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 420 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 479
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 480 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 536
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 537 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 596
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 597 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 642
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 643 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 701
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 702 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 761
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 762 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 821
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 822 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 879
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 880 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQNTSL 939
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 940 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 997
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 998 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1055
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1056 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1111
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1112 -FRKVQHEL 1119
Score = 89.8 bits (213), Expect = 7e-17
Identities = 194/1115 (17%), Positives = 461/1115 (41%), Gaps = 81/1115 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 71 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 130
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 131 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 188
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 189 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 247
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 248 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLEERLKKKDFELNAL 306
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 307 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 366
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 367 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 418
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 419 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 476
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 477 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 533
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 534 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 592
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT 721
DA L +KK+LA ++ + E + LE K ++LQN I++ M
Sbjct: 593 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK----HRLQNEIEDLMVDV 648
Query: 722 DKLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
++ +A +K KI E + K + ++++ ++ +EL K K+
Sbjct: 649 ERSNAAAAALDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTELFKLKN--- 702
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVV 837
EES+ +E + + +++ + Q S TI E E V + A M+ +
Sbjct: 703 AYEESLEHLETFKRENKNLQEEISDLTE--QLGSSGKTIHELEKVRKQLEAEKMELQSAL 760
Query: 838 EKQLLEIEHENKELQKK----NQILLEENQNLQISLSDMQQ---HYNALVEKANRTDLAE 890
E+ +EHE ++ + NQI E + L +M+Q ++ +V+ + AE
Sbjct: 761 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAE 820
Query: 891 SESTKYQTQLR-----DLESNLKRITHEHQTLIVQKKKEIEDLE-IEFNTQIESAIRDKK 944
+ S +++ DL +++H ++ + + +K+++ L+ + +TQI+ + D
Sbjct: 821 TRSRNEALRVKKKMEGDLNEMEIQLSHANR-MAAEAQKQVKSLQSLLKDTQIQ--LDDAV 877
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM-NLELIDKHVQKQQTQSPDY 1003
N+ ++NI V + LQ + + E K+ + ELI+ + Q S +
Sbjct: 878 RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQN- 936
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 937 -TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAH 994
Query: 1064 MQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTI 1118
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 995 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1054
Query: 1119 EPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQ 1177
+ + L++Q+ + +Q + + Q+ + + +K +
Sbjct: 1055 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1114
Query: 1178 LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
++ E + + Q+N+L++K + T+ N
Sbjct: 1115 VQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1149
Score = 81.8 bits (193), Expect = 2e-14
Identities = 189/917 (20%), Positives = 385/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 288 DKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 347
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 348 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 403
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 404 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 462
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 463 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 516
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 517 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 570
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 571 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 622
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 623 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 682
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 683 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 739
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 740 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 797
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 798 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 851
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 852 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 906
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + ++L + Q +S+ T ++ A L VE+ + E +
Sbjct: 907 VVEQTERSRKLADEELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 966
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 967 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1026
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1027 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1081
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1082 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1136
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1137 RA--KSRDIGTKGLNEE 1151
>Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9,
non-muscle protein.
Length = 1960
Score = 120 bits (290), Expect = 3e-26
Identities = 192/970 (19%), Positives = 411/970 (42%), Gaps = 92/970 (9%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++++ EK +L + ++++ + EE L A + E+ L +E+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 288 XXXXXXXLAK--QSIEPSCEEKTEIEEKGSLEIANMTELTKKIE----LLEHLNCQIRQT 341
+ + Q +E EE+ +K LE KK+E +LE NC++ +
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 342 NKELENKLATMGT-------ESKAVSSPSKKGSPLIS------------RKSGRNTASKM 382
K LE+++A T +SK+++ K +I+ R+ T K+
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS----LNKDLVDKEYVISE-KDTXXXX 437
+ + LS + K ++AK E +Q+ + ++ K + + ++
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
+ ++ + E Q+ G L + T ED + Q++L+ + E+ ++
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV-NIL 1172
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNM---IKVKSNHKLKLKQMQKTIDN-FSKVSDS 553
K L E+ K+ E QI ++ + A + + ++ K L++ ++T++N ++++
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 554 NKEIVRLTEELHHLSQKV-AELEE------EKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K +++ + H +KV A+L+E E ++ L D + +E D ++
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 607 NLAETRL-KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ ++L K S LESQ D QEL LQ +E KL+ ++L+ + LE
Sbjct: 1293 DSKSSKLTKDFSALESQLQD-TQEL--LQ---EENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 666 EQIDALSASKKELALV---IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ---ENMD 719
E+ +A +K++A + + ++K E G ++ E K + L+ Q E +
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
Query: 720 LTDKLEKMSA---EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
DKLEK +++ +LL ++H+ QS ++ K ++ D + ++ +KY
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSAC----NLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 777 RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAV 829
R E E + SL R ++ E ++ ++ + ++L++ +
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
L R +E+Q+ E++ + +EL+ + Q + L+++L M+ + + R + +
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER--DLQGRDEQS 1580
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEF---NTQIESAIRDK 943
E + + Q+R++E+ L+ + + +KK +++DLE N + AI+
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEY----KNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ L + + + + A +E K N + L E+ ++ EL K+Q Q
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700
Query: 1000 S--PDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESK----L 1050
+ ++ N K L++K + I L +++ Q +++D K +
Sbjct: 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ-GNTELINDRLKKANLQI 1759
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT-FEMNIPKT 1109
Q T L Q+ ++ N+EL++ ++E + +K + +T E I +
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 1110 EGMIISSTIE 1119
E + + T E
Sbjct: 1820 EEQLDNETKE 1829
Score = 113 bits (271), Expect = 7e-24
Identities = 191/967 (19%), Positives = 400/967 (41%), Gaps = 72/967 (7%)
Query: 148 SNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXXXXXXXXXX 204
+N +E++ + S+ ++K K E I DL+E++ ++ Q +E +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNK-HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSLEEANKLLE 261
+ K Q+ K +E A A ++E K LK I + +IS L+E +
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 262 AARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM 321
A+R + + L +ELE A+Q + E++ I +K E A
Sbjct: 1125 ASRNKAEKQKRDLGEELE--ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK- 1181
Query: 322 TELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK 381
T + ++ E +RQ + + +LA ++K V + +K + + G
Sbjct: 1182 ---THEAQIQE-----MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG------ 1227
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+L++E K ++++ K+E +Q L + E V +E
Sbjct: 1228 ------ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
L++Q + + + S + + +D E+ +QE+ +Q+L+ K V+D
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALE--SQLQDTQEL--LQEENRQKLSLSTKLKQVED- 1336
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-L 560
EK S EQ+ +E + A N+ K + ++ M+K +++ ++ +E+ R L
Sbjct: 1337 -EK-NSFREQL----EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 561 TEELHHLSQ----KVA---ELEEEKGNLQLH----LVDYDSGRMIESDVYKKMIEMENLA 609
++L LSQ KVA +LE+ K LQ LVD D R ++ KK + + L
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K IS +++ D + ++K + + + + E + +++
Sbjct: 1451 AEE-KTISAKYAEERDRAEA--EAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
L +SK ++ + L+ K L +++++ E++ ++LQ + L L+ M A
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+ +L + E+ K Q + +++E + +E+ + S + +LE + +E
Sbjct: 1568 QFERDLQGRDEQSEEKKKQ----LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
S + D+ L++ Q + + D+ ++ + EK+L +E E
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+LQ+ ++ E Q + + + + + + + LA E + + ++ LE L+
Sbjct: 1684 QLQE--ELAAAERAKRQ-AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE- 1739
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
E Q + I D + N QI+ D + +KN QLE Q +E K
Sbjct: 1740 ---EEQ----GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792
Query: 970 NIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
++ + V+ K ++ ++ + + + Q + T++ ++ K+ + ++ ++
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
+ NA+ Y ++L Q +LE EEE QR + ++ E+ +
Sbjct: 1853 DERRNAE-QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 1090 DQIKELK 1096
++ LK
Sbjct: 1912 REVSSLK 1918
Score = 108 bits (259), Expect = 2e-22
Identities = 189/1020 (18%), Positives = 421/1020 (41%), Gaps = 79/1020 (7%)
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA-- 670
L +S E + +EL +++K E++L ++ LQS Q+ +E + L+EQ+ A
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQS-QLMAE--KLQLQEQLQAET 893
Query: 671 ------------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENM 718
L+A K+EL + +L+ E+ + L+ +K+ + +Q ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 719 DLTDKLEKMSAEKI-SELLAKINHEEQSKIQTQ---FGIDAKIQERDL--YIENIESELS 772
+ +K+ EK+ +E K EEQ ++ Q + K+ E + + N+ E
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 773 KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
K KS + A++ D L R+ Q + ++K + T D++ A + +
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 833 HDRVVEKQLLEIE----HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
+ K+ E++ +E +KN + L++ + L+ +S++Q+ + E+A+R +
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKN-MALKKIRELESQISELQEDLES--ERASR-NK 1129
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
AE + +L L++ L+ + K +++ I T E A + + E
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQY 1007
+K+ + V +L QL++ K NL + L EL ++ V Q ++ +
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 1008 IN-EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEE 1063
+ ++ +L + + L K+ QV + ++S +SK ++ T +E +
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +++ +D+ +E E E I + +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLN 1182
D K+Q++ E + +R E+ +L++ T++ Q L+ L
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQR---HEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 1183 TELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH 1242
+L H + + + + K +QL E + + AE R + ++ + L +
Sbjct: 1427 VDL-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR-- 1483
Query: 1243 LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
A EA QK E E R+ F ++ E L+ S++++ K V +
Sbjct: 1484 -ALEEAMEQKAELE-RLN-KQFRTEMEDLM-----SSKDDVGKSV------------HEL 1523
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
E+ R L+++ ++ Q+E L E++ + A DL+ ++ ++
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 1363 QEQSILNINEENAQL---KKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
++Q + + E A+L +K + D EA + + ++ +K
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL-RK 1642
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
+ D+ R++++ K E E+E+ +++ E E +++
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM----IQLQEELAAAERAKRQ 1698
Query: 1480 SEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ ER +L +E+ + + E L ++A+L + LEEE T + L+ ++
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
I +N ++ NL+ + ++ + + + + ++++ T+ + ++ E +A
Sbjct: 1759 IDQINTDL-NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Score = 107 bits (258), Expect = 2e-22
Identities = 219/1115 (19%), Positives = 467/1115 (41%), Gaps = 113/1115 (10%)
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
+TL +QL E Q E + TE E +++ +L + E++++ DL ++
Sbjct: 872 ETLQSQLMAEKLQLQE-----QLQAETELCAEAEELRARLTAK-KQELEEI-CHDLEARV 924
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
+ EE+ L E +N+ +++ + + QK KV+ K + +L EE
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL--QLEKVTTEAK-LKKLEEEQI 981
Query: 566 HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFD 625
L + +L +EK L+ + ++ + E + K + +++N E + + ++
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 626 LVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
QEL ++K + L+D I++LQ+ +++ EE++ A A +E A +N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ-KN 1100
Query: 685 LKLDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
+ L K +L I +L+ D E ++ DL ++LE + E L + +E
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 744 -QSKIQTQFGI------------DAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+SK + + I +A+IQE +E + +L + K LE++
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 787 VMEDRRYSL--------------ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
+E+ R L E K ++ + LQE Q ++E EL +++ L
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
V L + + ++ +L K L + Q+ Q L + + +L K + E E
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV---EDE 1337
Query: 893 STKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLE--IEFNTQIESAI-RDKKVL 946
++ QL + E + + TL + KK++ED +E +++ + +D + L
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
++++E+ + +LE + +++L +++ + + NLE K + + +
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+Y E ++ A ++K+ + ++L + + A M ++ E QF T++E++
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEA----MEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDD 1124
V K + + ++ L+ V E Q++EL++ + TE + +
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELED-------ELQATEDAKLRLEV------ 1560
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII---QLETL 1181
N+ Q EE+ Q ++E A+L E ++ + +LE
Sbjct: 1561 --NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 1182 NTELTGH-DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
+L H D N+ + +K +L +L + + + + + R+S + Q A+ +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIK-QLRKLQAQMKDCMRELDDTRASREEILAQ-----AKENE 1672
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK-IVTMEQVTSLQNKL 1299
+ L EA+ + + EL A + + +Q D + + K + +E+ L+ ++
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERA-KRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 1300 QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
EE L ++ ++IN + ++ ++ +++ DL E +S+
Sbjct: 1732 AQLEEELEE-EQGNTELIND-RLKKANLQIDQI----------------NTDLNLE-RSH 1772
Query: 1360 KQMQEQSILNINEENAQLK-KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
Q E + + +N +LK K + EAK+ +L QL+ + E
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK-MHENANHYETMQ 1477
+ + T++ + ++V Q+ + + E Y+ +++ A RLK + E
Sbjct: 1833 ACKQ--VRRTEK--KLKDVLLQVDDERRNAEQ--YKDQADKASTRLKQLKRQLEEAEEEA 1886
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
+ + R KL EL + ++N++V+ L L
Sbjct: 1887 QRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 101 bits (241), Expect = 3e-20
Identities = 208/1123 (18%), Positives = 475/1123 (42%), Gaps = 94/1123 (8%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKS------NHKLKLK-QMQKTIDNFSKVSDSNK 555
E++ + EE++ ++ ++ AA + ++++ KL+L+ Q+Q + ++ +
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA 904
Query: 556 EIVRLTEELHHLSQKV-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ +EL + + A +EEE+ Q HL ++ +E E A +L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQ-HLQAEKKKMQQNIQELEEQLEEEESARQKLQ 963
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
+ K ++E I+ ++ KLA +L D++ ++ EE+ S S
Sbjct: 964 LEKVTTEAKLKKLEEEQII---LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE---KSKS 1017
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+L E + D E+ + + E KL+ ++ DL+D++ ++ A+ I+E
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG---DSTDLSDQIAELQAQ-IAE 1073
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L ++ +E+ ++ + ++++ ++ I + +S+I L+E + R
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIR----ELESQISELQEDLESERASRNK 1129
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
E++ LG L E K E T+ L + + + K+ LE E + E Q +
Sbjct: 1130 AEKQKRDLGEEL-EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 855 NQILLEENQNLQISLSDMQQ--HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
++ + +Q ++ ++Q A +EKA +T E+E + +++ L H
Sbjct: 1189 -EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT--LENERGELANEVKVLLQGKGDSEH 1245
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + + Q +++L+++FN ++ + + DK K + ++ VT L +Q +
Sbjct: 1246 KRKKVEAQ----LQELQVKFNEGERVRTELADKVT---KLQVELDNVTGLLSQSDSKSSK 1298
Query: 971 IENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ 1030
+ +E + EL+ + +Q+ +Q +E N L++++E L +
Sbjct: 1299 LTKDFSALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD-SKQHNEELQI------ 1083
+I + + V+D + K+ LE EE +++ K L S++H E++
Sbjct: 1358 QI----ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 1084 ----LVREQDDQIKEL---KETKLTFEMNIPKTEGMIISS-TIEPM-SDDANNVDXXXXX 1134
L +E DD + +L +++ E K + ++ TI +++ + +
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE 1194
L + EE +++++ L+ + + TE+++ + + EL ++
Sbjct: 1474 KETKALSL-ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 1195 QINQLKSKLEQLNTENDNLLSTV-AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ ++K++LE+L D L +T A+LR ++ + FE +L + Q E ++
Sbjct: 1533 QVEEMKTQLEELE---DELQATEDAKLRLEVNLQAMKAQFE-RDLQGRD-EQSEEKKKQL 1587
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEK 1312
++R + E + +Q +V + + E + + +E NK +D+ + LR LQ +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMD-LKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINE 1372
D + +++ R+ E E +A L+ E + ++ + Q+ +
Sbjct: 1647 MKDCMRELDDTRASRE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA----QQ 1701
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE---IYQKTHEYTITLTQ 1429
E +L EA++ +L +LE + I + + + + Q
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761
Query: 1430 RNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES----EIERV 1485
N + R + E + L + + L++K+ E ++ K S E +
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKE----LKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
+L E+L+ + E + KQV K L++ + + ++ + E + + + + L+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 1546 MV----------RASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ AS K+Q+ + A++T + ++ + NK
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy
chain protein.
Length = 1934
Score = 120 bits (290), Expect = 3e-26
Identities = 232/1107 (20%), Positives = 458/1107 (41%), Gaps = 100/1107 (9%)
Query: 471 NTEDVNEIAKVQEQ---LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ E E+A ++E+ LK+ L E + K+L EK+ S ++ L ++ A N+
Sbjct: 842 SAEREKEMASMKEEFTALKEAL--EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
+ +K I +KV + N+ + E L+ K +E+E L+ D
Sbjct: 900 DAEERCDQLIKNK---IQLEAKVKEMNERLEDEEEMNAELTAKKRNVEDECSELKR---D 953
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D + + V K+ EN + + ++ L+ L +E LQ+ + + D L
Sbjct: 954 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL--- 1010
Query: 648 SQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI 706
Q + D+V + K+ V LE+Q+D L S ++ V +L+ K +L G DL+ +E I
Sbjct: 1011 -QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG---DLKLTQESI 1066
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
M+ L+N + L ++L+K E ++ L A+I E+ Q Q K++E IE
Sbjct: 1067 MD-LEN---DKQQLDERLKKKDFE-LNALNARIEDEQALGSQLQ----KKLKELQARIEE 1117
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
+E EL R R A +E R L R+ +++ L+E A S Q + R
Sbjct: 1118 LEEELEA--ERTAR-----AKVEKLRSDLSRELEEISERLEEAGGATS---CQIEMNKKR 1167
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
A R +E+ L+ E L+KK+ + E L + ++Q+ L
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE---LGEQIDNLQRVKQKL------- 1217
Query: 887 DLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
E E ++++ +L D+ SN+++I L + + +ED E ++ E R L
Sbjct: 1218 ---EKEKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVNDL 1273
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+ K +L QL E + I L + LE + + ++++
Sbjct: 1274 TSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ-LEDLKRQLEEEVKAKNALAHA 1332
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN----MEE 1062
+ + + L +Q +EE A+ ++S S++AQ+ TK E E
Sbjct: 1333 LQSARHDCDLLREQYEEE--------TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1384
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
E++ K+L Q EE V + + L++TK + I E +++ +E +
Sbjct: 1385 ELEEAKKKLAQRLQEAEEA---VEAVNAKCSSLEKTKHRLQNEI---EDLMVD--VERSN 1436
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL---QECYTKIIQ-L 1178
A +D K Q+ EE E Q+++ L+TEL + Y + ++ L
Sbjct: 1437 AAAAALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL 1495
Query: 1179 ETLNTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
ET E + ++ EQ+ + +L L + EL+S++ A E
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 1236 AELWKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-NKIVTMEQV 1292
++ + L Q +A+ ++ E ++ + + +++DS+Q+S ET ++ +
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL 1352
++ L + E L + A+ Q++ L+S ++D ++
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1675
Query: 1353 RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK 1412
R N + + ++++ Q ++S RV ++ L +Q +
Sbjct: 1676 RRNNLQAELEELRAVVE------QTERSRKLADRELIETSERVQLLHSQNTSLINQKKKM 1729
Query: 1413 DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANH 1472
D+++ Q E + + + E ++ + + E+L E+++ + R+K +
Sbjct: 1730 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI 1789
Query: 1473 YETMQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEEEVAKTNEM 1522
+ + E E++ K +++L ++ E + K+ AE K + + + E+
Sbjct: 1790 KDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL 1849
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRA 1549
E ++ L D + LQ V+A
Sbjct: 1850 TYQTEEDRKNLLRLQDLVDKLQLKVKA 1876
Score = 108 bits (260), Expect = 1e-22
Identities = 201/954 (21%), Positives = 393/954 (41%), Gaps = 71/954 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTALKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + +
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRNV 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--- 1512
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
++ NEM+ L + ++ +LQ++++ + ++ V D K+
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE 1669
Score = 94.3 bits (224), Expect = 3e-18
Identities = 187/916 (20%), Positives = 390/916 (42%), Gaps = 80/916 (8%)
Query: 233 KDEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLEHSK-LAQELEQXXXXXXXXX 289
++ Q+ L D+++++ ++++L +A LE E SLE K + +LE+
Sbjct: 1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1059
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L ++SI +K +++E+ + + L +IE + L Q+++ KEL+ ++
Sbjct: 1060 K----LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
+ E +A + K L S S ++ + T Q K + E K
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLS--RELEEISERLEEAGGATSCQIEMNKKREAEFQK 1173
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
+ ++ + +K + Q +LE ++ L V
Sbjct: 1174 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ-KLEKEKSEFKLELDDVT 1232
Query: 470 TNTEDV----NEIAKVQEQLKQELND-----EIKDVNVKDLIE---KLKSAEEQITQLND 517
+N E + + K+ L+ ++N+ E +V DL KL++ ++++ D
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD 1292
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELEE 576
E +A + + K + +L+ +++ ++ K ++ ++ + L ++ E E
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 577 EKGNLQLHLVDYDS-----GRMIESDVYKKMIEMENL----------AETRLKAI----S 617
K LQ L +S E+D ++ E+E AE ++A+ S
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLA--DISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE K L E+ L + A D Q D++ +E K + E Q + S+ K
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
+ +L E KL K +++ LE K + NK N +E DLT++L S + I EL
Sbjct: 1473 EARSLSTELFKL-KNAYEESLEHLETFKRE--NK--NLQEEISDLTEQLGS-SGKTIHEL 1526
Query: 736 LAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDR 791
E K++ Q + +A ++ + I + E ++ K+ I R L E ME
Sbjct: 1527 EKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA 1586
Query: 792 RYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDH-DRV---VEKQLLEI 844
+ + R D L + L + ++ +E + ++ +N + + + H +R+ +KQ+ +
Sbjct: 1587 KRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1646
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
+ K+ Q + + N +L+ +++ +++ N E + E + R+L
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLQAELEELRAVVEQTERSRKLADRELI 1706
Query: 905 SNLKRI--THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
+R+ H T ++ +KK+++ + T++E A+++ + EK +K I +
Sbjct: 1707 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1766
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQK 1021
+L++ ++ +L E K N+E K +Q + ++ + ++ KL A +++
Sbjct: 1767 ELKKEQDTSAHL-----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1821
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
+ E+ A QK N V M E ++ + T + E + + R+ + L+D +L
Sbjct: 1822 ENELEA-EQKRNAESVKGM---RKSERRIKELTYQTEEDRKNLLRL-QDLVD------KL 1870
Query: 1082 QILVREQDDQIKELKE 1097
Q+ V+ Q +E +E
Sbjct: 1871 QLKVKAYKRQAEEAEE 1886
Score = 80.2 bits (189), Expect = 6e-14
Identities = 180/918 (19%), Positives = 391/918 (42%), Gaps = 84/918 (9%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK--IQERDLYIE---NIESELSKYKSRICRLE 782
+AE ++ + + + ++IQ + A ++E +E N+++EL + ++ + + E
Sbjct: 1636 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLQAELEELRAVVEQTE 1695
Query: 783 ESIAVMEDRRYSLERKA----DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
S + + + Q S + +K+K ++ + + E+ + + + +
Sbjct: 1696 RSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAK 1755
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTK-YQ 897
K + + +EL+K+ + + +L+ +M+Q + + +R D AE + K +
Sbjct: 1756 KAITDAAMMAEELKKEQ----DTSAHLERMKKNMEQ---TIKDLQHRLDEAEQIALKGGK 1808
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI--- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1809 KQLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRL 1863
Query: 955 -EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NK
Sbjct: 1864 QDLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNK 1918
Query: 1014 LNALLKQKDEEIIALNQK 1031
L A K +D LN++
Sbjct: 1919 LRA--KSRDIGTKGLNEE 1934
Score = 51.6 bits (118), Expect = 2e-05
Identities = 77/363 (21%), Positives = 161/363 (44%), Gaps = 31/363 (8%)
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM 1289
+ E +E ++ L ++ + +++L++Q+ A + + L D+ + Q NKI
Sbjct: 860 KEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA---EQDNLADAEERCDQLIKNKIQLE 916
Query: 1290 EQVTSLQNKLQDKEE-------HLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXX 1339
+V + +L+D+EE RN++++ +++ I+ +E+ +++E EK A
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRNVEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 1340 XXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE 1399
+ + K +QE +++ A+ K + +V+D E
Sbjct: 977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN-TLTKAKVKLEQQVDDLE 1035
Query: 1400 AKVLELTHQLELKDSEIYQKTHEYTITLTQRN-DEFENVRQQLVEYEKR----IEDLTYE 1454
LE ++ + D E ++ E + LTQ + + EN +QQL E K+ + L
Sbjct: 1036 GS-LEQEKKVRM-DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 1093
Query: 1455 KESELAI---LRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKA 1511
E E A+ L+ K+ E E +++E E ER V+ S L++++ E+++
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERT---ARAKVEKLRS-DLSRELEEISER 1149
Query: 1512 LEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQ 1571
LEE T+ + +E E + ++ A+++ ++K +D+ EQ
Sbjct: 1150 LEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK---HADSVAELGEQ 1206
Query: 1572 LDN 1574
+DN
Sbjct: 1207 IDN 1209
>X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain (1437
AA) protein.
Length = 1437
Score = 120 bits (290), Expect = 3e-26
Identities = 210/1122 (18%), Positives = 460/1122 (40%), Gaps = 71/1122 (6%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
K++ LK E + +K+ +K K + E++ ++K K++ +L Q
Sbjct: 337 KIKPLLKSA-ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL---Q 392
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY 599
+Q D+ + + +++++ +L ++V E EE+ + L E
Sbjct: 393 VQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSEL 452
Query: 600 KKMIEMENLAETRL-KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSE 658
KK I+ L ++ K E++ +L +E+ L + ++ + + + Q +
Sbjct: 453 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH-QQTLDD 511
Query: 659 IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENM 718
+++ E++++ L+ +K +L +++L+ EQ DLE K + L+ + M
Sbjct: 512 LQAE--EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 569
Query: 719 D-------LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
D L +KLEK E IS L++KI E+ +IQ Q KI+E IE + E+
Sbjct: 570 DNENDKQQLDEKLEKKEFE-ISNLISKIEDEQAVEIQLQ----KKIKELQARIEELGEEI 624
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL-AVL 830
++ + E+ + + + + ++ G + + + + +L L
Sbjct: 625 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEAT 684
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+ H+ +V + EL ++ L Q L+ S+++ + L A A+
Sbjct: 685 LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK 744
Query: 891 SESTK-YQTQLRDLESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVL 946
K L D S LK E Q LI ++ ++ E++ Q++ L
Sbjct: 745 GNLEKDGGRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQL 804
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+ + + + + +L+ QL+E + +N + + ++ + +L+ + +++Q + ++
Sbjct: 805 SRSKQASTQQIEELKHQLEE-ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE-LQR 862
Query: 1007 YINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
+++ N A + E + I +++ A+ + + E + K ++E+ Q
Sbjct: 863 ALSKANSEVAQWRTNTETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQ 922
Query: 1066 RVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
R+ + +LD ++ N L ++Q + K L E K +E +T+ + +S E
Sbjct: 923 RLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE----ETQAELEASQKESR 978
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
S + + E +E LQ++ + L ++ E +I +LE +
Sbjct: 979 SLSTE------LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI 1032
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
++ Q + + ++ LE + + + +++S + + ++ EI +L +
Sbjct: 1033 KKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1092
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-EETNKIV--TMEQVTSLQNK 1298
H E + E+R + A K + D + Q N++ ++ + Q
Sbjct: 1093 HTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGI 1152
Query: 1299 LQDKEEHL-------RNLQEKYADVINQIEILRSEIED-----EKVAFXXXXXXXXXXXX 1346
L++ + HL +L+E+ A V + +L++EIE+ E+
Sbjct: 1153 LKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDA 1212
Query: 1347 XXXXD-LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
L T+N S +++ ++++ +++++ + DA EL
Sbjct: 1213 SERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL 1272
Query: 1406 THQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESE 1458
+ + E +K E T+ L R DE E + ++Q+ + E R+ +L E E+E
Sbjct: 1273 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1332
Query: 1459 L-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV-SLNKQVAELNKAL 1512
A+ L+ HE T Q E + + V +++L K+ V S +Q E +
Sbjct: 1333 QKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQS 1392
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
++K ++Q LE E ++ L+ R +KI
Sbjct: 1393 NANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1434
Score = 103 bits (247), Expect = 5e-21
Identities = 198/992 (19%), Positives = 417/992 (42%), Gaps = 71/992 (7%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ +++ L +A LE E SLE
Sbjct: 482 EEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLE 541
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++S + +K +++EK + ++ L KIE
Sbjct: 542 QEKKLRMDLERAKRKLEGDLK----LAQESTMDNENDKQQLDEKLEKKEFEISNLISKIE 597
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ + Q+++ KEL+ ++ +G E +A ++ S + K + + +++ +L
Sbjct: 598 DEQAVEIQLQKKIKELQARIEELGEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 652
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
++NK A+ + + + L + + E +++ G+ I
Sbjct: 653 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL-RKKHADSMAELGEQ--I 709
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE 509
LQ Q+ + S + + T+D++ A+ + K L + +++D + +LK+ E
Sbjct: 710 DNLQRVKQKLEKEKSELKM--ETDDLSSNAEAISKAKGNLEKD-GGRSLEDQVSELKTKE 766
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
E+ +L +++ A + + +L + + S++S S + + EEL H
Sbjct: 767 EEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV---SQLSRSKQASTQQIEELKH--- 820
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAISLLESQ--KFDL 626
+LEEE S R + D+ ++ E E + L +A+S S+ ++
Sbjct: 821 ---QLEEETKAKNALAHALQSSRH-DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 876
Query: 627 VQELHILQ--QKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELALVIE 683
E +Q ++ +E + KLA Q + V K LE+ L ++L L +E
Sbjct: 877 NTETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 936
Query: 684 N-----LKLDKEQ--LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS--AEKISE 734
LDK+Q + + + E+ +L+ +E+ L+ +L K+ E+ +
Sbjct: 937 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 996
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L + E ++ Q + +I E I +E + + C ++ A +E+ S
Sbjct: 997 QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQ---AALEEAEAS 1053
Query: 795 LERKADQLGSYLQEKQKAYSEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL 851
LE + ++ E + SE ++DE +++L +H RVVE ++ E+
Sbjct: 1054 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHTRVVETMQSTLD---AEI 1108
Query: 852 QKKNQILLEENQNLQISLSDMQ---QHYNALVEKANRTDLAESESTKYQTQLRDLESNLK 908
+ +N L + ++ L++M+ H N L ++ R + ++ +TQL ++
Sbjct: 1109 RSRND-ALRVKKKMEGDLNEMEIQLNHANRLAAESLR-NYRNTQGILKETQLHLDDALRG 1166
Query: 909 RITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + Q IV+++ + EI E +E R +K+ ++ E V L Q
Sbjct: 1167 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1226
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
N + L +V +L E+I + ++ T+ + L K++D
Sbjct: 1227 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAM----MAEELKKEQDTSAHL 1282
Query: 1028 LNQKINNAQ-VSYMSMVSDYESKLAQFTTK--LENMEEEMQRVSKQLLDSKQHNEELQIL 1084
K N Q V + D +LA K ++ +E ++ + ++ + ++ N E
Sbjct: 1283 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG 1342
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
+R+ + ++KEL N+ + + ++ + S + K+
Sbjct: 1343 LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKL 1402
Query: 1145 QEEEEFIQERS-VLQEQSAKLNTELQECYTKI 1175
Q E E +ER+ + + Q KL + +E +TKI
Sbjct: 1403 QHELEEAEERADIAESQVNKLRVKSREVHTKI 1434
Score = 101 bits (241), Expect = 3e-20
Identities = 153/765 (20%), Positives = 318/765 (41%), Gaps = 49/765 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + + + +L + E + KEL++K LL+E +LQ+ +Q +
Sbjct: 342 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQSEAD 398
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+L + R + + + +++++ + E + KK+++ED E I+
Sbjct: 399 SLADAEERCEQLIKNKIQLEAKIKEVTERAEE-EEEINAELTAKKRKLEDECSELKKDID 457
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 458 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEED 517
Query: 995 KQQ--TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T++ EQ ++++ K+ ++ +K+ D E+ Q
Sbjct: 518 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDNENDKQQ 577
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KLE E E+ + ++ D + +LQ ++E +I+EL E + K E
Sbjct: 578 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 637
Query: 1113 --IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ L + E EF + R L+E A L E
Sbjct: 638 RSDLSRELEEISERLEE----AGGATSAQVELNKKREAEFQKLRRDLEE--ATLQHEAMV 691
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ +++ EL G + N +++ Q L+ + +L E D+ LS+ AE S ++
Sbjct: 692 AALRKKHADSM-AEL-GEQIDNLQRVKQKLEKEKSELKMETDD-LSSNAEAISKAKGNLE 748
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHEL---RVQLSAFESKYEQLLDSVQS-STQEETNK 1285
+ G E L +E + Q+ ++L R +L +Y + LD + +Q +K
Sbjct: 749 KDGGRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK 808
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ +Q+ L+++L+++ + L + ++LR + E+E+
Sbjct: 809 QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ--------EGKAEL 860
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 861 QRALSKANSEVAQWRTNTETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN-AKCASLEK 919
Query: 1406 THQL---ELKDSEI-YQKTHEYTITLTQRNDEFENV----RQQLVEYEKRIEDLTYEKES 1457
T Q E++D + ++++ L ++ F+ V +Q+ E + +E E S
Sbjct: 920 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS 979
Query: 1458 ---ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
EL ++ E+ + ET+++E++ + I +L +I E KQ+ EL K ++
Sbjct: 980 LSTELFKVKNVYEESLDQLETLRRENK-NLQQEISDLTEQIAEG---GKQIHELEKIKKQ 1035
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1036 VEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1080
Score = 94.3 bits (224), Expect = 3e-18
Identities = 201/1130 (17%), Positives = 464/1130 (41%), Gaps = 96/1130 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 345 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 404
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 405 ERCEQLIKNKIQLEAKIK-EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 463
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK-KINKNEIA 408
A + E A + K L +G + S + ET Q D + ++++
Sbjct: 464 AKVEKEKHATENKVKN---LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN 520
Query: 409 KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
L L + + D E + ++ K L L+L + M+
Sbjct: 521 ILTKAKTKLEQQVDDLEGSLEQE---KKLRMDLERAKRKLEGDLKLAQESTMD------- 570
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE-----KLKSAEEQITQLNDEIDAAN 523
N D ++ + E+ + E+++ I + + +E K+K + +I +L +EI+A
Sbjct: 571 --NENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAER 628
Query: 524 KNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL 583
+ K + +++++ + + + V L + ++ AE ++ + +L+
Sbjct: 629 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK------KREAEFQKLRRDLEE 682
Query: 584 HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
+ +++ M+ + K M L E I L+ K L +E L+ + D++
Sbjct: 683 ATLQHEA--MVAALRKKHADSMAELGE----QIDNLQRVKQKLEKEKSELKMETDDLSSN 736
Query: 644 LADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLE 700
IS+ + + +S LE+Q+ L ++E +I +L + +L G
Sbjct: 737 AEAISKAKGNLEKDGGRS--LEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL 794
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
++K+ ++++L + ++ S ++I EL ++ E ++K + + +
Sbjct: 795 DEKDALVSQL-----------SRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDC 843
Query: 761 DLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
DL E E E + K+ + R L ++ + + R + E A Q L+E +K ++ +
Sbjct: 844 DLLREQYEEE-QEGKAELQRALSKANSEVAQWRTNTETDAIQRTEELEEAKKKLAQRLQE 902
Query: 820 EDELVNRL-AVLMDHDRVVEKQLLEIEHENKELQKKN---QILLEENQNLQISLSDMQQH 875
+E V + A ++ ++ E+E ++++ N L ++ +N LS+ +Q
Sbjct: 903 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQK 962
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
Y E + ++ ES T+L +++ + + +TL ++E ++L+ E +
Sbjct: 963 YE---ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL----RRENKNLQQEISDL 1015
Query: 936 IESAIRDKKVLN--EKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
E K ++ EK +K +E +++A L+E + ++E+ + + ++ L +
Sbjct: 1016 TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRI-QLELNQVKSE 1074
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
V ++ + + +Q LK+ ++ Q +A++ + + K+
Sbjct: 1075 VDRKIAEKDEEIDQ-----------LKRNHTRVVETMQSTLDAEIRSRNDALRVKKKM-- 1121
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ----DDQIK---ELKETKLTFE-- 1103
L ME ++ ++ +S ++ Q +++E DD ++ +LKE E
Sbjct: 1122 -EGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERR 1180
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK 1163
N+ + E + +T+E ++ + + L + I + L+ ++
Sbjct: 1181 ANLLQAEIEELWATLE-QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ 1239
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
L +E++E + E + + E++ + + L NL TV +L+
Sbjct: 1240 LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1299
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQ-KTEHELRVQLSAFES--KYEQLLDSVQSSTQ 1280
+ A +Q + + Q L R + + + E+E + A + K+E+ + + T+
Sbjct: 1300 LDEA-EQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTE 1358
Query: 1281 EETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
E+ ++ ++ V LQ K++ + +E+ +++ L+ E+E+
Sbjct: 1359 EDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEE 1408
Score = 88.6 bits (210), Expect = 2e-16
Identities = 208/1102 (18%), Positives = 449/1102 (40%), Gaps = 132/1102 (11%)
Query: 216 QQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLA 275
++ ++ A + + +DE L KDI+ ++ ++ +E+ E ++ E + L
Sbjct: 429 EEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 488
Query: 276 QELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLN 335
+ +AK S +EK ++E + ++ K+ +L
Sbjct: 489 E-----------------TIAKLS-----KEKKALQETHQQTLDDLQAEEDKVNILTKAK 526
Query: 336 CQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLN 395
++ Q +LE L KK + R + + S + +E
Sbjct: 527 TKLEQQVDDLEGSL-----------EQEKKLRMDLERAKRKLEGDLKLAQESTMDNENDK 575
Query: 396 QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
Q D+K+ K E ++ + ++ V+ + K+ + ++ + E
Sbjct: 576 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 635
Query: 456 HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQL 515
Q+ L + E+ Q +L ++ E +KL+ E+ T
Sbjct: 636 KQRSDLSRELEEISERLEEAGGATSAQVELNKKREAE---------FQKLRRDLEEATLQ 686
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAEL 574
++ + AA ++ H + ++ + IDN +V KE L E LS +
Sbjct: 687 HEAMVAA------LRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 740
Query: 575 EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQ 634
+ KGNL + D GR +E V E++ E + + I+ L +Q+ L E
Sbjct: 741 SKAKGNL-----EKDGGRSLEDQV----SELKTKEEEQQRLINDLTAQRARLQTEAGEYS 791
Query: 635 QKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG 694
++ DE K A +SQL + S + L+ Q++ + +K LA +++ + D + L
Sbjct: 792 RQLDE---KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE 848
Query: 695 TIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
++ + K ++ L E E + ++ EL EE K Q
Sbjct: 849 QYEEEQEGKAELQRALSKANSEVAQWRTNTETDAIQRTEEL------EEAKKKLAQ---- 898
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQ---- 810
++QE + ++E + ++ + + RL+ + ED +ER ++ + L +KQ
Sbjct: 899 -RLQEAEEHVEAVNAKCASLEKTKQRLQNEV---EDLMLDVER-SNAACAALDKKQRNFD 953
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLS 870
K SE+ + +E L R + +L ++++ +E + + L EN+NLQ +S
Sbjct: 954 KVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEIS 1013
Query: 871 DMQQHY----NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE 926
D+ + + E E E + Q L + E++L+ HE + I++ + E+
Sbjct: 1014 DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE---HE-EGKILRIQLELN 1069
Query: 927 DLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-TQLEAQLQEYKNNIENLNMNVE-ELNKM 984
++ E + +I + L + + +E + + L+A+++ +N+ + +E +LN+M
Sbjct: 1070 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS-RNDALRVKKKMEGDLNEM 1128
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
++L H + +S Y N L D+ + Q+ Q++ + +
Sbjct: 1129 EIQL--NHANRLAAES---LRNYRNTQGILKETQLHLDDAL--RGQEDLKEQLAIVERRA 1181
Query: 1045 D-YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFE 1103
+ ++++ + LE E + ++LLD+ +E +Q+L Q L TK E
Sbjct: 1182 NLLQAEIEELWATLEQTERSRKIAEQELLDA---SERVQLL----HTQNTSLINTKKKLE 1234
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV-LQEQSA 1162
++ + + S +E + ++ N + + + ++E Q+ S L+
Sbjct: 1235 NDVSQ-----LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE--QDTSAHLERMKK 1287
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
L +++ ++ + E L L G ++QI +L++++ +L E +N AE
Sbjct: 1288 NLEQTVKDLQHRLDEAEQL--ALKG----GKKQIQKLEARVRELEGEVENEQKRNAE--- 1338
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
AV +G E + L + + +K L+ + ++K + + + +E+
Sbjct: 1339 ----AV--KGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEA-EEQ 1391
Query: 1283 TNKIVTMEQVTSLQNKLQDKEE 1304
+N + + LQ++L++ EE
Sbjct: 1392 SN--ANLSKFRKLQHELEEAEE 1411
>CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein.
Length = 1960
Score = 120 bits (290), Expect = 3e-26
Identities = 192/970 (19%), Positives = 411/970 (42%), Gaps = 92/970 (9%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++++ EK +L + ++++ + EE L A + E+ L +E+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 288 XXXXXXXLAK--QSIEPSCEEKTEIEEKGSLEIANMTELTKKIE----LLEHLNCQIRQT 341
+ + Q +E EE+ +K LE KK+E +LE NC++ +
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 342 NKELENKLATMGT-------ESKAVSSPSKKGSPLIS------------RKSGRNTASKM 382
K LE+++A T +SK+++ K +I+ R+ T K+
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS----LNKDLVDKEYVISE-KDTXXXX 437
+ + LS + K ++AK E +Q+ + ++ K + + ++
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
+ ++ + E Q+ G L + T ED + Q++L+ + E+ ++
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV-NIL 1172
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNM---IKVKSNHKLKLKQMQKTIDN-FSKVSDS 553
K L E+ K+ E QI ++ + A + + ++ K L++ ++T++N ++++
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 554 NKEIVRLTEELHHLSQKV-AELEE------EKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K +++ + H +KV A+L+E E ++ L D + +E D ++
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 607 NLAETRL-KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ ++L K S LESQ D QEL LQ +E KL+ ++L+ + LE
Sbjct: 1293 DSKSSKLTKDFSALESQLQD-TQEL--LQ---EENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 666 EQIDALSASKKELALV---IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ---ENMD 719
E+ +A +K++A + + ++K E G ++ E K + L+ Q E +
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
Query: 720 LTDKLEKMSA---EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
DKLEK +++ +LL ++H+ QS ++ K ++ D + ++ +KY
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSAC----NLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 777 RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAV 829
R E E + SL R ++ E ++ ++ + ++L++ +
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
L R +E+Q+ E++ + +EL+ + Q + L+++L M+ + + R + +
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER--DLQGRDEQS 1580
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEF---NTQIESAIRDK 943
E + + Q+R++E+ L+ + + +KK +++DLE N + AI+
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEY----KNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ L + + + + A +E K N + L E+ ++ EL K+Q Q
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700
Query: 1000 S--PDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESK----L 1050
+ ++ N K L++K + I L +++ Q +++D K +
Sbjct: 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ-GNTELINDRLKKANLQI 1759
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT-FEMNIPKT 1109
Q T L Q+ ++ N+EL++ ++E + +K + +T E I +
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 1110 EGMIISSTIE 1119
E + + T E
Sbjct: 1820 EEQLDNETKE 1829
Score = 113 bits (271), Expect = 7e-24
Identities = 191/967 (19%), Positives = 400/967 (41%), Gaps = 72/967 (7%)
Query: 148 SNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXXXXXXXXXX 204
+N +E++ + S+ ++K K E I DL+E++ ++ Q +E +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNK-HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSLEEANKLLE 261
+ K Q+ K +E A A ++E K LK I + +IS L+E +
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 262 AARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM 321
A+R + + L +ELE A+Q + E++ I +K E A
Sbjct: 1125 ASRNKAEKQKRDLGEELE--ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK- 1181
Query: 322 TELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK 381
T + ++ E +RQ + + +LA ++K V + +K + + G
Sbjct: 1182 ---THEAQIQE-----MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG------ 1227
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+L++E K ++++ K+E +Q L + E V +E
Sbjct: 1228 ------ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
L++Q + + + S + + +D E+ +QE+ +Q+L+ K V+D
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALE--SQLQDTQEL--LQEENRQKLSLSTKLKQVED- 1336
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-L 560
EK S EQ+ +E + A N+ K + ++ M+K +++ ++ +E+ R L
Sbjct: 1337 -EK-NSFREQL----EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 561 TEELHHLSQ----KVA---ELEEEKGNLQLH----LVDYDSGRMIESDVYKKMIEMENLA 609
++L LSQ KVA +LE+ K LQ LVD D R ++ KK + + L
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K IS +++ D + ++K + + + + E + +++
Sbjct: 1451 AEE-KTISAKYAEERDRAEA--EAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
L +SK ++ + L+ K L +++++ E++ ++LQ + L L+ M A
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+ +L + E+ K Q + +++E + +E+ + S + +LE + +E
Sbjct: 1568 QFERDLQGRDEQSEEKKKQ----LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
S + D+ L++ Q + + D+ ++ + EK+L +E E
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+LQ+ ++ E Q + + + + + + + LA E + + ++ LE L+
Sbjct: 1684 QLQE--ELAAAERAKRQ-AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE- 1739
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
E Q + I D + N QI+ D + +KN QLE Q +E K
Sbjct: 1740 ---EEQ----GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792
Query: 970 NIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
++ + V+ K ++ ++ + + + Q + T++ ++ K+ + ++ ++
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
+ NA+ Y ++L Q +LE EEE QR + ++ E+ +
Sbjct: 1853 DERRNAE-QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 1090 DQIKELK 1096
++ LK
Sbjct: 1912 REVSSLK 1918
Score = 108 bits (259), Expect = 2e-22
Identities = 189/1020 (18%), Positives = 421/1020 (41%), Gaps = 79/1020 (7%)
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA-- 670
L +S E + +EL +++K E++L ++ LQS Q+ +E + L+EQ+ A
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQS-QLMAE--KLQLQEQLQAET 893
Query: 671 ------------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENM 718
L+A K+EL + +L+ E+ + L+ +K+ + +Q ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 719 DLTDKLEKMSAEKI-SELLAKINHEEQSKIQTQ---FGIDAKIQERDL--YIENIESELS 772
+ +K+ EK+ +E K EEQ ++ Q + K+ E + + N+ E
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 773 KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
K KS + A++ D L R+ Q + ++K + T D++ A + +
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 833 HDRVVEKQLLEIE----HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
+ K+ E++ +E +KN + L++ + L+ +S++Q+ + E+A+R +
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKN-MALKKIRELESQISELQEDLES--ERASR-NK 1129
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
AE + +L L++ L+ + K +++ I T E A + + E
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQY 1007
+K+ + V +L QL++ K NL + L EL ++ V Q ++ +
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 1008 IN-EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEE 1063
+ ++ +L + + L K+ QV + ++S +SK ++ T +E +
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +++ +D+ +E E E I + +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLN 1182
D K+Q++ E + +R E+ +L++ T++ Q L+ L
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQR---HEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 1183 TELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH 1242
+L H + + + + K +QL E + + AE R + ++ + L +
Sbjct: 1427 VDL-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR-- 1483
Query: 1243 LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
A EA QK E E R+ F ++ E L+ S++++ K V +
Sbjct: 1484 -ALEEAMEQKAELE-RLN-KQFRTEMEDLM-----SSKDDVGKSV------------HEL 1523
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
E+ R L+++ ++ Q+E L E++ + A DL+ ++ ++
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 1363 QEQSILNINEENAQL---KKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
++Q + + E A+L +K + D EA + + ++ +K
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL-RK 1642
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
+ D+ R++++ K E E+E+ +++ E E +++
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM----IQLQEELAAAERAKRQ 1698
Query: 1480 SEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ ER +L +E+ + + E L ++A+L + LEEE T + L+ ++
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
I +N ++ NL+ + ++ + + + + ++++ T+ + ++ E +A
Sbjct: 1759 IDQINTDL-NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Score = 107 bits (258), Expect = 2e-22
Identities = 219/1115 (19%), Positives = 467/1115 (41%), Gaps = 113/1115 (10%)
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
+TL +QL E Q E + TE E +++ +L + E++++ DL ++
Sbjct: 872 ETLQSQLMAEKLQLQE-----QLQAETELCAEAEELRARLTAK-KQELEEI-CHDLEARV 924
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
+ EE+ L E +N+ +++ + + QK KV+ K + +L EE
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL--QLEKVTTEAK-LKKLEEEQI 981
Query: 566 HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFD 625
L + +L +EK L+ + ++ + E + K + +++N E + + ++
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 626 LVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
QEL ++K + L+D I++LQ+ +++ EE++ A A +E A +N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ-KN 1100
Query: 685 LKLDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
+ L K +L I +L+ D E ++ DL ++LE + E L + +E
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 744 -QSKIQTQFGI------------DAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+SK + + I +A+IQE +E + +L + K LE++
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 787 VMEDRRYSL--------------ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
+E+ R L E K ++ + LQE Q ++E EL +++ L
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
V L + + ++ +L K L + Q+ Q L + + +L K + E E
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV---EDE 1337
Query: 893 STKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLE--IEFNTQIESAI-RDKKVL 946
++ QL + E + + TL + KK++ED +E +++ + +D + L
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
++++E+ + +LE + +++L +++ + + NLE K + + +
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+Y E ++ A ++K+ + ++L + + A M ++ E QF T++E++
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEA----MEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDD 1124
V K + + ++ L+ V E Q++EL++ + TE + +
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELED-------ELQATEDAKLRLEV------ 1560
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII---QLETL 1181
N+ Q EE+ Q ++E A+L E ++ + +LE
Sbjct: 1561 --NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 1182 NTELTGH-DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
+L H D N+ + +K +L +L + + + + + R+S + Q A+ +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIK-QLRKLQAQMKDCMRELDDTRASREEILAQ-----AKENE 1672
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK-IVTMEQVTSLQNKL 1299
+ L EA+ + + EL A + + +Q D + + K + +E+ L+ ++
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERA-KRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 1300 QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
EE L ++ ++IN + ++ ++ +++ DL E +S+
Sbjct: 1732 AQLEEELEE-EQGNTELIND-RLKKANLQIDQI----------------NTDLNLE-RSH 1772
Query: 1360 KQMQEQSILNINEENAQLK-KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
Q E + + +N +LK K + EAK+ +L QL+ + E
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK-MHENANHYETMQ 1477
+ + T++ + ++V Q+ + + E Y+ +++ A RLK + E
Sbjct: 1833 ACKQ--VRRTEK--KLKDVLLQVDDERRNAEQ--YKDQADKASTRLKQLKRQLEEAEEEA 1886
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
+ + R KL EL + ++N++V+ L L
Sbjct: 1887 QRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 101 bits (241), Expect = 3e-20
Identities = 208/1123 (18%), Positives = 475/1123 (42%), Gaps = 94/1123 (8%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKS------NHKLKLK-QMQKTIDNFSKVSDSNK 555
E++ + EE++ ++ ++ AA + ++++ KL+L+ Q+Q + ++ +
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA 904
Query: 556 EIVRLTEELHHLSQKV-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ +EL + + A +EEE+ Q HL ++ +E E A +L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQ-HLQAEKKKMQQNIQELEEQLEEEESARQKLQ 963
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
+ K ++E I+ ++ KLA +L D++ ++ EE+ S S
Sbjct: 964 LEKVTTEAKLKKLEEEQII---LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE---KSKS 1017
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+L E + D E+ + + E KL+ ++ DL+D++ ++ A+ I+E
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG---DSTDLSDQIAELQAQ-IAE 1073
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L ++ +E+ ++ + ++++ ++ I + +S+I L+E + R
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIR----ELESQISELQEDLESERASRNK 1129
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
E++ LG L E K E T+ L + + + K+ LE E + E Q +
Sbjct: 1130 AEKQKRDLGEEL-EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 855 NQILLEENQNLQISLSDMQQ--HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
++ + +Q ++ ++Q A +EKA +T E+E + +++ L H
Sbjct: 1189 -EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT--LENERGELANEVKVLLQGKGDSEH 1245
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + + Q +++L+++FN ++ + + DK K + ++ VT L +Q +
Sbjct: 1246 KRKKVEAQ----LQELQVKFNEGERVRTELADKVT---KLQVELDNVTGLLSQSDSKSSK 1298
Query: 971 IENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ 1030
+ +E + EL+ + +Q+ +Q +E N L++++E L +
Sbjct: 1299 LTKDFSALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD-SKQHNEELQI------ 1083
+I + + V+D + K+ LE EE +++ K L S++H E++
Sbjct: 1358 QI----ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 1084 ----LVREQDDQIKEL---KETKLTFEMNIPKTEGMIISS-TIEPM-SDDANNVDXXXXX 1134
L +E DD + +L +++ E K + ++ TI +++ + +
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE 1194
L + EE +++++ L+ + + TE+++ + + EL ++
Sbjct: 1474 KETKALSL-ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 1195 QINQLKSKLEQLNTENDNLLSTV-AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ ++K++LE+L D L +T A+LR ++ + FE +L + Q E ++
Sbjct: 1533 QVEEMKTQLEELE---DELQATEDAKLRLEVNLQAMKAQFE-RDLQGRD-EQSEEKKKQL 1587
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEK 1312
++R + E + +Q +V + + E + + +E NK +D+ + LR LQ +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMD-LKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINE 1372
D + +++ R+ E E +A L+ E + ++ + Q+ +
Sbjct: 1647 MKDCMRELDDTRASRE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA----QQ 1701
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE---IYQKTHEYTITLTQ 1429
E +L EA++ +L +LE + I + + + + Q
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761
Query: 1430 RNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES----EIERV 1485
N + R + E + L + + L++K+ E ++ K S E +
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKE----LKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
+L E+L+ + E + KQV K L++ + + ++ + E + + + + L+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 1546 MV----------RASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ AS K+Q+ + A++T + ++ + NK
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy
polypeptide 9 protein.
Length = 1960
Score = 120 bits (290), Expect = 3e-26
Identities = 192/970 (19%), Positives = 411/970 (42%), Gaps = 92/970 (9%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++++ EK +L + ++++ + EE L A + E+ L +E+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 288 XXXXXXXLAK--QSIEPSCEEKTEIEEKGSLEIANMTELTKKIE----LLEHLNCQIRQT 341
+ + Q +E EE+ +K LE KK+E +LE NC++ +
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 342 NKELENKLATMGT-------ESKAVSSPSKKGSPLIS------------RKSGRNTASKM 382
K LE+++A T +SK+++ K +I+ R+ T K+
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS----LNKDLVDKEYVISE-KDTXXXX 437
+ + LS + K ++AK E +Q+ + ++ K + + ++
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
+ ++ + E Q+ G L + T ED + Q++L+ + E+ ++
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV-NIL 1172
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNM---IKVKSNHKLKLKQMQKTIDN-FSKVSDS 553
K L E+ K+ E QI ++ + A + + ++ K L++ ++T++N ++++
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 554 NKEIVRLTEELHHLSQKV-AELEE------EKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K +++ + H +KV A+L+E E ++ L D + +E D ++
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 607 NLAETRL-KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ ++L K S LESQ D QEL LQ +E KL+ ++L+ + LE
Sbjct: 1293 DSKSSKLTKDFSALESQLQD-TQEL--LQ---EENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 666 EQIDALSASKKELALV---IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ---ENMD 719
E+ +A +K++A + + ++K E G ++ E K + L+ Q E +
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
Query: 720 LTDKLEKMSA---EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
DKLEK +++ +LL ++H+ QS ++ K ++ D + ++ +KY
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSAC----NLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 777 RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAV 829
R E E + SL R ++ E ++ ++ + ++L++ +
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
L R +E+Q+ E++ + +EL+ + Q + L+++L M+ + + R + +
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER--DLQGRDEQS 1580
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEF---NTQIESAIRDK 943
E + + Q+R++E+ L+ + + +KK +++DLE N + AI+
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEY----KNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ L + + + + A +E K N + L E+ ++ EL K+Q Q
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700
Query: 1000 S--PDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESK----L 1050
+ ++ N K L++K + I L +++ Q +++D K +
Sbjct: 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ-GNTELINDRLKKANLQI 1759
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT-FEMNIPKT 1109
Q T L Q+ ++ N+EL++ ++E + +K + +T E I +
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 1110 EGMIISSTIE 1119
E + + T E
Sbjct: 1820 EEQLDNETKE 1829
Score = 113 bits (271), Expect = 7e-24
Identities = 191/967 (19%), Positives = 400/967 (41%), Gaps = 72/967 (7%)
Query: 148 SNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXXXXXXXXXX 204
+N +E++ + S+ ++K K E I DL+E++ ++ Q +E +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNK-HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSLEEANKLLE 261
+ K Q+ K +E A A ++E K LK I + +IS L+E +
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 262 AARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM 321
A+R + + L +ELE A+Q + E++ I +K E A
Sbjct: 1125 ASRNKAEKQKRDLGEELE--ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK- 1181
Query: 322 TELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK 381
T + ++ E +RQ + + +LA ++K V + +K + + G
Sbjct: 1182 ---THEAQIQE-----MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG------ 1227
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+L++E K ++++ K+E +Q L + E V +E
Sbjct: 1228 ------ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
L++Q + + + S + + +D E+ +QE+ +Q+L+ K V+D
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALE--SQLQDTQEL--LQEENRQKLSLSTKLKQVED- 1336
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-L 560
EK S EQ+ +E + A N+ K + ++ M+K +++ ++ +E+ R L
Sbjct: 1337 -EK-NSFREQL----EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 561 TEELHHLSQ----KVA---ELEEEKGNLQLH----LVDYDSGRMIESDVYKKMIEMENLA 609
++L LSQ KVA +LE+ K LQ LVD D R ++ KK + + L
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K IS +++ D + ++K + + + + E + +++
Sbjct: 1451 AEE-KTISAKYAEERDRAEA--EAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
L +SK ++ + L+ K L +++++ E++ ++LQ + L L+ M A
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
+ +L + E+ K Q + +++E + +E+ + S + +LE + +E
Sbjct: 1568 QFERDLQGRDEQSEEKKKQ----LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
S + D+ L++ Q + + D+ ++ + EK+L +E E
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+LQ+ ++ E Q + + + + + + + LA E + + ++ LE L+
Sbjct: 1684 QLQE--ELAAAERAKRQ-AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE- 1739
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
E Q + I D + N QI+ D + +KN QLE Q +E K
Sbjct: 1740 ---EEQ----GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792
Query: 970 NIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
++ + V+ K ++ ++ + + + Q + T++ ++ K+ + ++ ++
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
+ NA+ Y ++L Q +LE EEE QR + ++ E+ +
Sbjct: 1853 DERRNAE-QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 1090 DQIKELK 1096
++ LK
Sbjct: 1912 REVSSLK 1918
Score = 108 bits (259), Expect = 2e-22
Identities = 189/1020 (18%), Positives = 421/1020 (41%), Gaps = 79/1020 (7%)
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA-- 670
L +S E + +EL +++K E++L ++ LQS Q+ +E + L+EQ+ A
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQS-QLMAE--KLQLQEQLQAET 893
Query: 671 ------------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENM 718
L+A K+EL + +L+ E+ + L+ +K+ + +Q ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 719 DLTDKLEKMSAEKI-SELLAKINHEEQSKIQTQ---FGIDAKIQERDL--YIENIESELS 772
+ +K+ EK+ +E K EEQ ++ Q + K+ E + + N+ E
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 773 KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
K KS + A++ D L R+ Q + ++K + T D++ A + +
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 833 HDRVVEKQLLEIE----HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
+ K+ E++ +E +KN + L++ + L+ +S++Q+ + E+A+R +
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKN-MALKKIRELESQISELQEDLES--ERASR-NK 1129
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
AE + +L L++ L+ + K +++ I T E A + + E
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQY 1007
+K+ + V +L QL++ K NL + L EL ++ V Q ++ +
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 1008 IN-EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEE 1063
+ ++ +L + + L K+ QV + ++S +SK ++ T +E +
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +++ +D+ +E E E I + +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLN 1182
D K+Q++ E + +R E+ +L++ T++ Q L+ L
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQR---HEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 1183 TELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH 1242
+L H + + + + K +QL E + + AE R + ++ + L +
Sbjct: 1427 VDL-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR-- 1483
Query: 1243 LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
A EA QK E E R+ F ++ E L+ S++++ K V +
Sbjct: 1484 -ALEEAMEQKAELE-RLN-KQFRTEMEDLM-----SSKDDVGKSV------------HEL 1523
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
E+ R L+++ ++ Q+E L E++ + A DL+ ++ ++
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 1363 QEQSILNINEENAQL---KKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
++Q + + E A+L +K + D EA + + ++ +K
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL-RK 1642
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
+ D+ R++++ K E E+E+ +++ E E +++
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM----IQLQEELAAAERAKRQ 1698
Query: 1480 SEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ ER +L +E+ + + E L ++A+L + LEEE T + L+ ++
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
I +N ++ NL+ + ++ + + + + ++++ T+ + ++ E +A
Sbjct: 1759 IDQINTDL-NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Score = 107 bits (258), Expect = 2e-22
Identities = 219/1115 (19%), Positives = 467/1115 (41%), Gaps = 113/1115 (10%)
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
+TL +QL E Q E + TE E +++ +L + E++++ DL ++
Sbjct: 872 ETLQSQLMAEKLQLQE-----QLQAETELCAEAEELRARLTAK-KQELEEI-CHDLEARV 924
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
+ EE+ L E +N+ +++ + + QK KV+ K + +L EE
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL--QLEKVTTEAK-LKKLEEEQI 981
Query: 566 HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFD 625
L + +L +EK L+ + ++ + E + K + +++N E + + ++
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 626 LVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
QEL ++K + L+D I++LQ+ +++ EE++ A A +E A +N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ-KN 1100
Query: 685 LKLDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
+ L K +L I +L+ D E ++ DL ++LE + E L + +E
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 744 -QSKIQTQFGI------------DAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+SK + + I +A+IQE +E + +L + K LE++
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 787 VMEDRRYSL--------------ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
+E+ R L E K ++ + LQE Q ++E EL +++ L
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
V L + + ++ +L K L + Q+ Q L + + +L K + E E
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV---EDE 1337
Query: 893 STKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLE--IEFNTQIESAI-RDKKVL 946
++ QL + E + + TL + KK++ED +E +++ + +D + L
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
++++E+ + +LE + +++L +++ + + NLE K + + +
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+Y E ++ A ++K+ + ++L + + A M ++ E QF T++E++
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEA----MEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDD 1124
V K + + ++ L+ V E Q++EL++ + TE + +
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELED-------ELQATEDAKLRLEV------ 1560
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII---QLETL 1181
N+ Q EE+ Q ++E A+L E ++ + +LE
Sbjct: 1561 --NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 1182 NTELTGH-DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
+L H D N+ + +K +L +L + + + + + R+S + Q A+ +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIK-QLRKLQAQMKDCMRELDDTRASREEILAQ-----AKENE 1672
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK-IVTMEQVTSLQNKL 1299
+ L EA+ + + EL A + + +Q D + + K + +E+ L+ ++
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERA-KRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 1300 QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
EE L ++ ++IN + ++ ++ +++ DL E +S+
Sbjct: 1732 AQLEEELEE-EQGNTELIND-RLKKANLQIDQI----------------NTDLNLE-RSH 1772
Query: 1360 KQMQEQSILNINEENAQLK-KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
Q E + + +N +LK K + EAK+ +L QL+ + E
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK-MHENANHYETMQ 1477
+ + T++ + ++V Q+ + + E Y+ +++ A RLK + E
Sbjct: 1833 ACKQ--VRRTEK--KLKDVLLQVDDERRNAEQ--YKDQADKASTRLKQLKRQLEEAEEEA 1886
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
+ + R KL EL + ++N++V+ L L
Sbjct: 1887 QRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 101 bits (241), Expect = 3e-20
Identities = 208/1123 (18%), Positives = 475/1123 (42%), Gaps = 94/1123 (8%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKS------NHKLKLK-QMQKTIDNFSKVSDSNK 555
E++ + EE++ ++ ++ AA + ++++ KL+L+ Q+Q + ++ +
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA 904
Query: 556 EIVRLTEELHHLSQKV-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ +EL + + A +EEE+ Q HL ++ +E E A +L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQ-HLQAEKKKMQQNIQELEEQLEEEESARQKLQ 963
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
+ K ++E I+ ++ KLA +L D++ ++ EE+ S S
Sbjct: 964 LEKVTTEAKLKKLEEEQII---LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE---KSKS 1017
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+L E + D E+ + + E KL+ ++ DL+D++ ++ A+ I+E
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG---DSTDLSDQIAELQAQ-IAE 1073
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L ++ +E+ ++ + ++++ ++ I + +S+I L+E + R
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIR----ELESQISELQEDLESERASRNK 1129
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
E++ LG L E K E T+ L + + + K+ LE E + E Q +
Sbjct: 1130 AEKQKRDLGEEL-EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 855 NQILLEENQNLQISLSDMQQ--HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
++ + +Q ++ ++Q A +EKA +T E+E + +++ L H
Sbjct: 1189 -EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT--LENERGELANEVKVLLQGKGDSEH 1245
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + + Q +++L+++FN ++ + + DK K + ++ VT L +Q +
Sbjct: 1246 KRKKVEAQ----LQELQVKFNEGERVRTELADKVT---KLQVELDNVTGLLSQSDSKSSK 1298
Query: 971 IENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ 1030
+ +E + EL+ + +Q+ +Q +E N L++++E L +
Sbjct: 1299 LTKDFSALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD-SKQHNEELQI------ 1083
+I + + V+D + K+ LE EE +++ K L S++H E++
Sbjct: 1358 QI----ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 1084 ----LVREQDDQIKEL---KETKLTFEMNIPKTEGMIISS-TIEPM-SDDANNVDXXXXX 1134
L +E DD + +L +++ E K + ++ TI +++ + +
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE 1194
L + EE +++++ L+ + + TE+++ + + EL ++
Sbjct: 1474 KETKALSL-ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 1195 QINQLKSKLEQLNTENDNLLSTV-AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ ++K++LE+L D L +T A+LR ++ + FE +L + Q E ++
Sbjct: 1533 QVEEMKTQLEELE---DELQATEDAKLRLEVNLQAMKAQFE-RDLQGRD-EQSEEKKKQL 1587
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEK 1312
++R + E + +Q +V + + E + + +E NK +D+ + LR LQ +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMD-LKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINE 1372
D + +++ R+ E E +A L+ E + ++ + Q+ +
Sbjct: 1647 MKDCMRELDDTRASRE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA----QQ 1701
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE---IYQKTHEYTITLTQ 1429
E +L EA++ +L +LE + I + + + + Q
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761
Query: 1430 RNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES----EIERV 1485
N + R + E + L + + L++K+ E ++ K S E +
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKE----LKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
+L E+L+ + E + KQV K L++ + + ++ + E + + + + L+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 1546 MV----------RASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ AS K+Q+ + A++T + ++ + NK
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 protein.
Length = 3225
Score = 120 bits (289), Expect = 4e-26
Identities = 291/1528 (19%), Positives = 634/1528 (41%), Gaps = 142/1528 (9%)
Query: 93 SLANTLKQKEILMEKIKQYKE---LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSN 149
SL+ K K++ +E ++ + L +T++R V H+S+
Sbjct: 766 SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 825
Query: 150 TIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXX 209
++E ALS ++++ M+ +L+ + + Q IE K++ T
Sbjct: 826 KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 885
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISL 269
++ ++E + + +K+++ +D E + +E + + ++ E+
Sbjct: 886 EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH 945
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
E L +E EQ L Q + EE ++++ EI ++E T++ E
Sbjct: 946 EFDLLKKENEQRKRKLQAALINRKELL-QRVSRLEEELANLKDESKKEIP-LSE-TERGE 1002
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ E + NKE K T + + + + R + + Q
Sbjct: 1003 VEED------KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1056
Query: 390 SS--ETLNQDTDKKIN-----KNEIAKLEMVIQSL---NKDLVDKEYVISEKDTXXXX-- 437
+ + +NQ K N + EI++ + +IQ L N D D + V K+T
Sbjct: 1057 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1116
Query: 438 -XXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K L + L LE ++ L T+ + + + K QE+ ++ L +E+K
Sbjct: 1117 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI--LKKAQEK-ERHLREELK- 1172
Query: 496 VNVKDLIEKLKSAEEQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
KD +L+ ++ ++ N+ I D + I+V+ + KL + ++ S
Sbjct: 1173 -QQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ-ESCSSTPGLE 1230
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS--GRMIESDVYKKMIEME-NLAET 611
+ + + TE+ HH +Q V E + H D + G + + ++ E+E E
Sbjct: 1231 EPLFKATEQ-HH-TQPVLE-SNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1287
Query: 612 RLKAISLLESQKFDLVQELHILQQKYD----EVED--KLADISQLQSDQVCSEIKSVHLE 665
LK +S S+ +E+ LQ++ + E+E ++ +++ ++ + +++S L+
Sbjct: 1288 ELK-VSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ 1346
Query: 666 ----EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT 721
E + L EL +I + D L G + ++KE + K+Q I E DL
Sbjct: 1347 IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL----SEKEAALTKIQTEIIEQEDLI 1402
Query: 722 DKLE---KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
L +M A++ E + ++ E Q I + + + +++ L K
Sbjct: 1403 KALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKE-- 1460
Query: 779 CRLEESIAVMEDRRYSLER-KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
L+E+ ++ E+ SL R ++L L + + S ++D ++ RLA+L +
Sbjct: 1461 -ALKENKSLQEE--LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE----- 1512
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE-SESTKY 896
E+ L E + L+ NQ L ++L+++L + + LV++ ++ +EST++
Sbjct: 1513 ERDKLITEMDRSLLE--NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1570
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
Q + ++L+ + +++Q + + + +E+ ++K+ L K
Sbjct: 1571 QEKHKELQKEYE--------ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1622
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMN----LELIDKHVQKQQTQSP--DYTEQYINE 1010
+ E QLQE + +E + + + K LEL +++ + + P D ++ +
Sbjct: 1623 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1682
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE-NMEEEMQRVSK 1069
+ NA +K++ E + + ++ S MS ++ ++E N+ ++ +
Sbjct: 1683 LLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEAT 1742
Query: 1070 QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIP--KTEGMIISSTIEPMSDDA 1125
+ D++ + E Q + E ++Q T+ T ++P K+ +S D+
Sbjct: 1743 EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFS-SHDEI 1801
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
NN L EEE + + Q + NT L + TK +L+ L E+
Sbjct: 1802 NNYLQQIDQLKERIAGL----EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1857
Query: 1186 TGHDVVNQE------QINQLKSKLEQLNTE-NDNLLSTVAELRSSISSAVD-----QRGF 1233
T +++NQ+ ++ +LK E+ + + L++ +AEL SI + Q
Sbjct: 1858 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN 1917
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKY-EQLLDSVQSSTQEETNKIVTMEQV 1292
E+ E ++L + ++ ++ + +L + + ES+ ++ L+ +Q + +E NK
Sbjct: 1918 ELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK----SHA 1973
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL 1352
LQ L++K++ ++ LQ+ +I L + + + F +
Sbjct: 1974 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTV--KALEF-----------------V 2014
Query: 1353 RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK 1412
+TE+Q ++ ++++ E KK+ ++A A+V L L+LK
Sbjct: 2015 QTESQKDLEITKENLAQAVEHR---KKAQAELASFKVLLDDTQSEA-ARV--LADNLKLK 2068
Query: 1413 DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANH 1472
E+ + Q++++ E +Q E + + EK L ++ + E
Sbjct: 2069 -KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE 2127
Query: 1473 YETMQKESEIERVKLIEELNVKITESVSLNKQVAEL----NKALEEEVAKTNEMQTALEN 1528
+ + + E +L E L+ +T+ + K ++ L ++ ++E + A+++
Sbjct: 2128 IQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS 2187
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+E EI D + L++ +R S +++
Sbjct: 2188 KEEEIRLKEDNCSVLKDQLRQMSIHMEE 2215
Score = 119 bits (286), Expect = 1e-25
Identities = 286/1462 (19%), Positives = 592/1462 (40%), Gaps = 120/1462 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKA--TTXXXXXXXX 202
T L KE D + LQV++ M+ ++ E+ K QI A +
Sbjct: 1407 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1466
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDI----ESKDVRISSLEEANK 258
T +++TK + + + EK +L + E +D I+ ++ +
Sbjct: 1467 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS-- 1524
Query: 259 LLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCE--EK-TEIEEKGS 315
LLE S E KLA LE L I S E EK E++++
Sbjct: 1525 LLENQSLSSSCESLKLA--LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE 1582
Query: 316 LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSG 375
+ + + ++ + E ++H+ +RQ +EL KL + K ++ +
Sbjct: 1583 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1642
Query: 376 RNTASKMKSPWSQLSSETLNQDTDKKINK-NEIAK--LEMVIQSLNKDLVDKEYVISEKD 432
+ L E N +++ + AK +E ++ S + E V E +
Sbjct: 1643 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1702
Query: 433 TXXXXXXXXXXGKDTLIAQLQ-LEHQQHMEGPSLIHVGTN-TEDVNEIAKVQEQLKQELN 490
T KD+L ++Q L+HQ +EG TE + V E+ Q +
Sbjct: 1703 TLSKKFQSLMSEKDSLSEEVQDLKHQ--IEGNVSKQANLEATEKHDNQTNVTEEGTQSIP 1760
Query: 491 DEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVK--SNHKLKLKQMQKTIDNFS 548
E ++ + + + + E + A +K+ +N+ ++ Q+++ I
Sbjct: 1761 GETEEQDSLSMSTR-PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1819
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
+ NKE + E + + ++++ + G L++ + ++ + +++ + L
Sbjct: 1820 EEKQKNKEFSQTLE--NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1877
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
ET + LE + + + EL+ Y +V D +Q++++ + SE+K+ L++
Sbjct: 1878 KETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD-----AQIKNELLESEMKN--LKKC 1930
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK-----LQNYIQENMDLTD 722
+ L K++L V E K++ E ++ ++ +++ NK LQ ++E
Sbjct: 1931 VSELEEEKQQL--VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 1988
Query: 723 KLEK---MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
+L+K EKIS L + E +QT+ D +I + EN+ + K
Sbjct: 1989 QLQKDCIRYQEKISALERTVKALEF--VQTESQKDLEITK-----ENLAQAVEHRKKAQA 2041
Query: 780 RLEESIAVMEDRRYSLERK-AD--QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV 836
L +++D + R AD +L LQ +++ Q+DE + R + +
Sbjct: 2042 ELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2101
Query: 837 VEKQLLEIEHENKELQKKNQILLEEN-QNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
EK+ ++ E + ++ ++ LEE +Q++L+ + L E + T + TK
Sbjct: 2102 KEKKNMQ---EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTK 2158
Query: 896 YQTQLRDLESNL----KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ L+D + K+ + I K++EI L+ + + ++ +R + E+ +
Sbjct: 2159 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR-LKEDNCSVLKDQLRQMSIHMEELK 2217
Query: 952 KNIEYVTQLEAQLQEYKNNIE-NLNMNV-EELNKMNLELIDK-------------HVQKQ 996
NI + + Q+ E K E L V + L N EL+ + + K
Sbjct: 2218 INISRLEH-DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2276
Query: 997 QTQSPDYTEQYINEINKLNALLKQKD--EEIIALNQK-INNAQVSYMSMVSDYESKLAQF 1053
+++ +Q + N L +QK E II + I N++ SY + +D ++ +
Sbjct: 2277 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS-REL 2335
Query: 1054 TTKL-ENMEEEMQRVSKQLLDSKQHNEELQIL-VREQDDQIKELKETKLTFEMNIPKTEG 1111
T++L E + + Q++ LL K+ ++ I +R+Q D KE+KE + + E
Sbjct: 2336 TSRLHEEINMKEQKIIS-LLSGKEEAIQVAIAELRQQHD--KEIKELENLLSQE--EEEN 2390
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+++ + D N + K Q + F++ S LQ ++ + Q+
Sbjct: 2391 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS-FVKSMSSLQNDRDRIVGDYQQL 2449
Query: 1172 YTK----IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+ I++ + L E + +E+I L+S ++ LN+EN L + + + R ++
Sbjct: 2450 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2509
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + + +L + L Q+ + + +L +L E E L S ++ QEE +
Sbjct: 2510 ITIKDSQQKQLLEVQL-QQNKELENKYAKLEEKLKESEEANEDLRRSF-NALQEEKQDL- 2566
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
+++ SL+ + + LQE+ + ++ ++++E+V
Sbjct: 2567 -SKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL---KVKEEEV---HRLSALFSSSQK 2619
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
+L E +Q+++ + E +LKK AE +V EL
Sbjct: 2620 RIAELEEE---LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELAR 2676
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
L E+ QK + +T+ N Q +++ EL L+ K
Sbjct: 2677 DL----VEMEQK----LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYD 2728
Query: 1468 ENANHYETMQKESEI--ERVKLIEE--LNVKITESVSLNKQVAELNKALEEEVAKTNEMQ 1523
+ ++++ + ER L+ E ++ TE SL+ + +LN+ L + + +
Sbjct: 2729 ASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLS-HLEKLNQQLLSKDEQLLHLS 2787
Query: 1524 TALENQEIEIVTLNDEITNLQN 1545
+ LE+ ++ + + + +LQN
Sbjct: 2788 SQLEDSYNQVQSFSKAMASLQN 2809
Score = 117 bits (282), Expect = 3e-25
Identities = 257/1153 (22%), Positives = 477/1153 (41%), Gaps = 118/1153 (10%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEI--KDVNV--KD--LIEKLKSAEEQITQL----NDEI 519
T EDV E EQL EL D I KDV + KD L E+ K+A+ +I +L ++
Sbjct: 6 TTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKL 65
Query: 520 DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
+ NK + ++K+ L ++ + SK S+ E E++ H K+ E EE
Sbjct: 66 TSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH---KLQEKEELIS 122
Query: 580 NLQLHLVDYDSGRMIESDV-YKKMIEMENLAETRLKAISLLESQ----KFDLVQELHILQ 634
LQ L + + +S ++ + M+ + + + IS L++Q + + +L +Q
Sbjct: 123 TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQLSSMQ 182
Query: 635 QKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG 694
Q E + + +L D++ + L Q D + +++L ++ L+ +E L G
Sbjct: 183 QVVREKDARFETQVRLHEDEL------LQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 236
Query: 695 TIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
+ ++ + +L Q N L+ +L++M AE + E+SKI + ++
Sbjct: 237 RAQVVDL----LQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE-KME 291
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS 814
++ ER L N++ E+ + + ++ A +E R +LE+K + ++EK
Sbjct: 292 LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHK---AEMEEKTSHIL 348
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
EL + L D + +K LQ KN+ ++ Q +Q +QQ
Sbjct: 349 SLQKTGQELQSACDALKDQN-------------SKLLQDKNEQAVQSAQTIQQLEDQLQQ 395
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ + NR L + E T QT D+ + +T E+ I +K + +LE E
Sbjct: 396 KSKEISQFLNRLPLQQHE-TASQTSFPDVYNEGTQAVTEEN---IASLQKRVVELENEKG 451
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
+ S+I + + L + EK +T LEAQ N + V E++ +++ +K
Sbjct: 452 ALLLSSI-ELEELKAENEKLSSQITLLEAQ-----NRTGEADREVSEIS--IVDIANKRS 503
Query: 994 QKQQTQSPDYTEQYINEINK-LNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ D E ++ +K L+ LL K+ EEI L ++ + +D+E
Sbjct: 504 SSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE----EADHE-V 558
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
L Q +++ ME E K + + ++ ++ E+ KE T +
Sbjct: 559 LDQ--KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSE 616
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQ 1169
E + + +E S + + ++E + +S + E + + Q
Sbjct: 617 EISLNDAGVELKSTKQDG-----DKSLSAVPDIGQCHQDELERLKSQILELELNFH-KAQ 670
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQE---QINQLKSKLEQLNTENDNLLSTVAELR--SSI 1224
E Y K L+ E++ + + +E + S L+ E D LLS V EL + +
Sbjct: 671 EIYEK--NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTEL 728
Query: 1225 SSAVDQRGFEIAELWKQ----HLAQREADFQKTE--HELRVQLSAFESKYEQL---LDSV 1275
+ V Q +AE +Q + +Q D TE H L ++ + + K E L LD V
Sbjct: 729 RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDV 788
Query: 1276 QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFX 1335
Q E++ I SLQ++LQ+KE + E+ + +++E L + +++
Sbjct: 789 QLQFSEQSTLI------RSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEIT 842
Query: 1336 XXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
+T + +Q+ E S ++ E+ QL + ++
Sbjct: 843 KMDQLLLEKKRDVETLQQTIEEKDQQVTEIS-FSMTEKMVQLNEEKFSLGVEIKTLKEQL 901
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
N L + E E ++ +E + L Q DE Q E + DL +K
Sbjct: 902 N--------LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL-LKK 952
Query: 1456 ESELAILRLKMHENANHYETMQKESEIER--VKLIEELNVKITESVSLNKQVAELNKALE 1513
E+E +L+ N E +Q+ S +E L +E +I S + +V E +
Sbjct: 953 ENEQRKRKLQA-ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE-----D 1006
Query: 1514 EEVAKTNEMQTALENQEIEIV---TLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDE 1570
+E + +E + QEIEI T++++ LQ++ + K+ F + KQ
Sbjct: 1007 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1066
Query: 1571 QLDNTMNKELLDA 1583
D T +LL A
Sbjct: 1067 LQDKTNQIDLLQA 1079
Score = 116 bits (279), Expect = 7e-25
Identities = 234/1271 (18%), Positives = 522/1271 (41%), Gaps = 98/1271 (7%)
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
+I ELE K+++ +E S + I+++ + K S +++ +E+L Q
Sbjct: 1279 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQ 1338
Query: 397 DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
+ ++ +IA LE ++ L L + + +IS+K+ K+ + ++Q E
Sbjct: 1339 KLES--SQLQIAGLEH-LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI 1395
Query: 457 QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK-DLIEKLKSAEEQITQL 515
+ + +H + AK ++ ++L E+ ++ K + I + A++QI +
Sbjct: 1396 IEQEDLIKALHTQLEMQ-----AKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1450
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKEIVRLTEELHHLSQKVAEL 574
+ K +K + + +L + TI+ +K ++D ++ +E + ++A L
Sbjct: 1451 LQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALL 1510
Query: 575 EEEKGNLQLHLV-DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHIL 633
+EE+ L + + + S + +E L E + K + +ES K + E
Sbjct: 1511 QEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1570
Query: 634 QQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
Q+K+ E++ + EI L + + +S + + V+E ++ +K++LY
Sbjct: 1571 QEKHKELQKEY-------------EI----LLQSYENVSNEAERIQHVVEAVRQEKQELY 1613
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
G ++ E +K++ +LQ QE ++ +K+ K + K ++L EE +++ + +
Sbjct: 1614 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILEL--EEENDRLRAE--V 1669
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
+E + S + K + R++ + + SL + D L +Q+ K
Sbjct: 1670 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD-LKHQ 1728
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E + + + + V E+ I E +E ++ + + S+ +
Sbjct: 1729 IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE---QDSLSMSTRPTCSESVPSAK 1785
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
A+ + + D E Y Q+ L+ + + E Q + K+ + LE E N
Sbjct: 1786 SANPAVSKDFSSHD----EINNYLQQIDQLKERIAGLEEEKQ----KNKEFSQTLENEKN 1837
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
T + S I K + ++ + + L Q+QE + + L EE K +LE + +
Sbjct: 1838 TLL-SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE-EKDDLE---ERL 1892
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQF 1053
Q + Y ++ + + E+ L + ++ + +V + ++K+
Sbjct: 1893 MNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE-KTKVESE 1951
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
K E++Q K+ +K H +ELQ L++E+ ++K+L++ + ++ I E +
Sbjct: 1952 IRK--EYLEKIQGAQKE-PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTV 2008
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE--EFIQERSVLQEQSAKLNTELQEC 1171
+E + ++ L++ +E + ++ R Q + A L +
Sbjct: 2009 --KALEFVQTESQK-------------DLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2053
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQI-NQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
++ ++ N +L N+E + +Q+K K E L + + + ++ +D
Sbjct: 2054 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2113
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL--LDSVQSSTQEETNKIV- 1287
E L ++ + + + K + E++ +S QL SS Q++ ++++
Sbjct: 2114 LRREKVHL-EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2172
Query: 1288 -TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
+ + +Q KEE +R ++ + + +Q+ + +E+ K+
Sbjct: 2173 EAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWES 2232
Query: 1347 XXXXDLRTENQSYKQMQ--EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
+++ + + +Q + +L+ EE L SS + D ++ +
Sbjct: 2233 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD---QLTD 2289
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAI--- 1461
L++ LE K E QK + I Q D ++ YE+ DL +E +
Sbjct: 2290 LSNSLE-KCKE--QKGNLEGIIRQQEAD----IQNSKFSYEQLETDLQASRELTSRLHEE 2342
Query: 1462 LRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE----VA 1517
+ +K + + ++ ++ +L ++ + +I E +L Q E N LEEE V
Sbjct: 2343 INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2402
Query: 1518 KTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMN 1577
KTN++ L+ + E + + L + V++ SS D +Q + L +
Sbjct: 2403 KTNQLMETLKTIKKENI---QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2459
Query: 1578 KELLDAVPRAE 1588
K+ L AE
Sbjct: 2460 KDQLIQEAAAE 2470
Score = 112 bits (270), Expect = 9e-24
Identities = 277/1471 (18%), Positives = 594/1471 (40%), Gaps = 141/1471 (9%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDV---RISSLEEANKLLEAARFEI 267
E+ K + K+ +EA+ + E R + +I D+ R SS EE+ + +
Sbjct: 461 EELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ--DVLENTF 518
Query: 268 SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
S +H +L+ L + L + E + E + +E +E + + K
Sbjct: 519 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMK 578
Query: 328 IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS 387
+ LE E E+ L + E + S+ + +G S +
Sbjct: 579 V-FLEDTGQDFPLMPNE-ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 636
Query: 388 QLSSET----LNQDTDKKINKNEIAKLEMVIQSLN----KDLVDKEYVISEKDTXXXXXX 439
LS+ +QD +++ K++I +LE+ K+L +K IS +
Sbjct: 637 SLSAVPDIGQCHQDELERL-KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFK 695
Query: 440 XXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
+ L E Q + + + TE ++ +++ L + D +
Sbjct: 696 KNADNNSSAFTALSEERDQLLS--QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQ 753
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNM-IKVKSNH----KLKLKQMQKTIDNF-SKVSDS 553
+ L + EQI L+ I+A +K++ I+V N +L+ + I + S++ +
Sbjct: 754 TAHDNLLT--EQIHSLS--IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNK 809
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM--------IESDVYKKMIEM 605
E++ E + H+S KV EL + +L + D + ++ + +K ++
Sbjct: 810 ESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV 869
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED-KLADISQLQSDQVCSEIKSVHL 664
++ + + + L +KF L E+ L+++ + + + A Q++ D S +
Sbjct: 870 TEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 929
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+E A SK+EL + LK + EQ ++ ++++++ ++ +E +L D+
Sbjct: 930 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 989
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEE 783
+K +E ++ ++++K ++ + +K QE ++Y++ SE I + LEE
Sbjct: 990 KKEIPLSETER-GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1048
Query: 784 SIA-------VMEDRRYSLERKADQ---LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
+A +++ +L+ K +Q L + + E Q + + + +V +
Sbjct: 1049 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1108
Query: 834 DRVVEKQLL--EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN------R 885
+ VV EH EL++K L +E + LQ L + A+++KA R
Sbjct: 1109 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1168
Query: 886 TDLAESES--TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
+L + + + Q Q + + I + + L +Q ++ I D ++ Q ES
Sbjct: 1169 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI-DGKLPSTDQQESCSSTP 1227
Query: 944 KVLNEKYEKNIEYVTQ--LEAQL-QEYKNNIENLN--------------MNVEELNKMNL 986
+ ++ ++ TQ LE+ L ++ ++ E+ + + E K+ L
Sbjct: 1228 GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1287
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINK-------LNALLKQKDEEIIALNQKINNAQVSY 1039
EL + T+ + Q +INK L + + + +L QK+ ++Q+
Sbjct: 1288 ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI 1347
Query: 1040 MSM--VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ + + + KL + + EE++ +S QL + + ++Q + EQ+D IK L
Sbjct: 1348 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL-H 1406
Query: 1098 TKLTFEMNIPKTEGMIISSTIE--PMSDDANNVDXXXXXXXXXXXXLKVQ--EEEEFIQE 1153
T+L EM + + I +E M + L+ +E ++E
Sbjct: 1407 TQL--EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1464
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETL----NTE---LTGHDVVNQEQINQLKSKLEQL 1206
LQE+ + ++ + +E+ N E + G + QE+ ++L +++++
Sbjct: 1465 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1524
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELR----VQ 1260
EN +L S+ L+ ++ + + + E+ K ++Q+ EL+ +
Sbjct: 1525 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1584
Query: 1261 LSAFES------KYEQLLDSVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKY 1313
L ++E+ + + ++++V+ QE K+ + E + +LQ+ E+ + ++EK
Sbjct: 1585 LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKM 1644
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ E+E+E L + N S K+ E+ + E
Sbjct: 1645 RKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELER----VKME 1700
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVL-ELTHQLELKDSEIYQKTHEYTITLTQRND 1432
L K V D + ++ ++ Q L+ +E + T TQ +
Sbjct: 1701 YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ-SI 1759
Query: 1433 EFENVRQQLVEYEKR---IEDLTYEKESELAILR-LKMHENANHYETMQKESEIERVKLI 1488
E Q + R E + K + A+ + H+ N+Y ++++ +
Sbjct: 1760 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY--------LQQIDQL 1811
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT--NLQN- 1545
+E + E NK E ++ LE E N + + + ++ E+ L +E+T NL N
Sbjct: 1812 KERIAGLEEEKQKNK---EFSQTLENE---KNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1865
Query: 1546 MVRASSSKIQKHVSFASDTKQGRDEQLDNTM 1576
++ S++ K A + K +E+L N +
Sbjct: 1866 QIQEELSRVTKLKETAEEEKDDLEERLMNQL 1896
Score = 103 bits (246), Expect = 7e-21
Identities = 252/1309 (19%), Positives = 530/1309 (40%), Gaps = 122/1309 (9%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGT----ESKAVSSPSKKGSPLISRKSGRNTASK 381
KK++L H ++ NK +E A GT E ++ SK +
Sbjct: 55 KKLKL--HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 112
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMV-IQSLNKDLVDKEYVISEKDTXXXXXXX 440
+L S Q T + + + EM + + L +KE IS
Sbjct: 113 KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA 172
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD 500
+ + + Q+ E E +H + V + A V+ +++Q+L + +++
Sbjct: 173 EQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQ-ADVETEMQQKLR--VLQRKLEE 229
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
E L + + L E+ AA + ++ S +++ T+ N + +I+
Sbjct: 230 HEESLVGRAQVVDLLQQELTAAEQRN-QILSQQLQQMEAEHNTLRNTVETEREESKILLE 288
Query: 561 TEELHHLSQKVA--ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
EL +K++ L+EE +L L + E + +E ++ AE K +
Sbjct: 289 KMELEVAERKLSFHNLQEEMHHL-LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 347
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
L QK QEL Q D ++D+ + + Q +++Q +++ E D L KE+
Sbjct: 348 LSLQKTG--QEL---QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE--DQLQQKSKEI 400
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNK-LQNYIQENM-DLTDKLEKMSAEKISELL 736
+ + L L + + + D+ N+ Q +EN+ L ++ ++ EK + LL
Sbjct: 401 SQFLNRLPLQQHETAS-----QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 455
Query: 737 AKINHEE----QSKIQTQFGIDAKIQERDLYIENIESELSKY---KSRICRLEESIAVME 789
+ I EE K+ +Q + + Q R + SE+S R EES +
Sbjct: 456 SSIELEELKAENEKLSSQITL-LEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL 514
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
+ +S + K +L L E ++A E + +L + A DH+ + +K++ ++E E
Sbjct: 515 ENTFSQKHK--ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 572
Query: 850 ELQKKNQILLEENQ------NLQISLSDMQ------QHYNALVEKANRTDLA-ESESTKY 896
K L + Q N + SL ++ +H + E+ + D E +STK
Sbjct: 573 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK- 631
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKV--------L 946
Q + L S + I HQ + + K +I +LE+ F+ +I D+K L
Sbjct: 632 QDGDKSL-SAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 690
Query: 947 NEKYEKNIEY----VTQLEAQLQEYKNNIENLNMNVE---ELNKMNLELIDKHVQKQ-QT 998
E+++KN + T L + + + ++ L+M E ++ ++ + L + Q++
Sbjct: 691 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 750
Query: 999 QSPDYTEQYINE-INKLNALLKQKDEEIIALNQKINNAQVSY---MSMVSDYESKLAQFT 1054
+S + + E I+ L+ K KD +I L ++++ Q+ + +++ +S+L
Sbjct: 751 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 810
Query: 1055 TKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+++ E ++ +S ++ + Q + ++ + + D + E K T + I + + +
Sbjct: 811 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 870
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE--EEFIQERSVLQEQSAKLNTELQECY 1172
+ M++ ++ LK Q + + E+ ++++ L++ Y
Sbjct: 871 EISFS-MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 929
Query: 1173 TKIIQLETLNTELTGH--DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
++ ++ E H D++ +E Q K KL+ LL V+ L +++ D+
Sbjct: 930 DEMSPAGQISKEELQHEFDLLKKEN-EQRKRKLQAALINRKELLQRVSRLEEELANLKDE 988
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME 1290
EI L + + E D + E+ + SK +++ ++ + E K V ++
Sbjct: 989 SKKEI-PLSETERGEVEEDKENKEYSEK----CVTSKCQEIEIYLKQTISE---KEVELQ 1040
Query: 1291 QV-TSLQNKLQDKEEH---LRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
+ L+ KL +E+ ++ + + D NQI++L++EI + +
Sbjct: 1041 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1100
Query: 1347 XXXXDLRTE-----------NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
L E ++ +K E+ IL + +E QL+K +
Sbjct: 1101 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1160
Query: 1396 NDAEAKVLELTHQLELK-DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
+ E + E ELK + Y + E +++ E EN+ QL + + ++ + + +
Sbjct: 1161 QEKERHLRE-----ELKQQKDDYNRLQE---QFDEQSKENENIGDQLRQLQIQVRE-SID 1211
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNV-----KITESVSL---NKQVA 1506
+ + E + K +E + + E N+ +E S VA
Sbjct: 1212 GKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1271
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ 1555
++ L+E A+ E++ + + E+ ++E+ LQ + +I+
Sbjct: 1272 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1320
Score = 89.8 bits (213), Expect = 7e-17
Identities = 161/840 (19%), Positives = 342/840 (40%), Gaps = 63/840 (7%)
Query: 320 NMTELTKKIELLEHLNCQI----RQTNKELENKLA-TMGTESKAVSSPSKKGSPLISRKS 374
+M EL I LEH + QI QT +L+ K+ T+ E+K + S ++ L S
Sbjct: 2212 HMEELKINISRLEH-DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYH--S 2268
Query: 375 GRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTX 434
+N +K++S L + + + K + LE +I+ D+ + ++ + +T
Sbjct: 2269 SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2328
Query: 435 XXXXXXXXXGKDTLIAQLQLEHQQHMEGPS-LIHVGT---NTEDVNEIAKVQEQLKQELN 490
I + + + G I V + EI +++ L QE
Sbjct: 2329 LQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2388
Query: 491 DEI--KDVNVK------DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH--------K 534
+ I ++ N K L+E LK+ +++ Q ++D+ K+M ++++ +
Sbjct: 2389 ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ 2448
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
L+ + + ++ + ++ E +L EE+ L + +L E L L+ Y +
Sbjct: 2449 LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED--L 2506
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
+ K + + L E +L+ LE++ L ++L ++ +++ + + + D
Sbjct: 2507 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD- 2565
Query: 655 VCSEIKSV-----HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK 709
+ EI+S+ L Q+ AL + L L LK+ +E+++ + ++ I
Sbjct: 2566 LSKEIESLKVSISQLTRQVTALQ-EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2624
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+ + + K+ ++ +K+ + L ++H+ + ++ E + +E
Sbjct: 2625 EEELVCVQKEAAKKVGEIE-DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2683
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT-----IQEDELV 824
+L L I SL+ D L E ++ Y ++E L+
Sbjct: 2684 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2743
Query: 825 NRL--AVLMDH----DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
NR A+L + + E L +E N++L K++ LL + L+ S + +Q A
Sbjct: 2744 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2803
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
+ N D +E K+ R E +R + T + + ++ +
Sbjct: 2804 MASLQNERDHLWNELEKF----RKSEEGKQRSAAQPSTSPAEVQS-LKKAMSSLQNDRDR 2858
Query: 939 AIRDKKVLNEKYEKNIEYVTQL---EAQLQEYKNNIENLNMNVEELNKMNL----ELIDK 991
+++ K L ++Y + + +T+L +AQLQEY++ + + EEL + NL EL
Sbjct: 2859 LLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELDQL 2918
Query: 992 HVQKQQTQSPD--YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++K + + EQY+ I+ + L I L + Q + +
Sbjct: 2919 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 2978
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ +N+ E + + QL DS + + ++ +++ + +L E K T + + T
Sbjct: 2979 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDT 3038
Score = 83.8 bits (198), Expect = 5e-15
Identities = 273/1549 (17%), Positives = 623/1549 (40%), Gaps = 136/1549 (8%)
Query: 67 VSKRIKEHRKATAELLGRPFVPGISESLANTLK---QKEILMEKIKQYKELSKRSSTTIV 123
++K I+E + +L P P E L+ K ++E+ +EKIK + + +T+
Sbjct: 68 LNKYIEEMKAQGGTVL--PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 125
Query: 124 RXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD 183
++ + + ++EK+ +S LQ ++ T + +++
Sbjct: 126 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLS---QTQAEQAAQLSSMQ 182
Query: 184 QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDI 243
Q++ K+ A D + T+MQ+ ++ + ++ ++ L+
Sbjct: 183 QVVREKD-ARFETQVRLHEDELLQLVTQADVE---TEMQQKLRVLQRKLEEHEESLVGRA 238
Query: 244 ESKDV---RISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSI 300
+ D+ +++ E+ N++L ++ EH+ L +E L K +
Sbjct: 239 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE------TEREESKILLEKMEL 292
Query: 301 EPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVS 360
E + E K L N+ E + LLE Q Q ELE++ + + E K +
Sbjct: 293 EVA-------ERK--LSFHNLQE--EMHHLLEQFE-QAGQAQAELESRYSAL--EQKHKA 338
Query: 361 SPSKKGSPLIS-RKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE-IAKLEMVIQSLN 418
+K S ++S +K+G+ S + Q +S+ L ++ + + I +LE +Q +
Sbjct: 339 EMEEKTSHILSLQKTGQELQSACDALKDQ-NSKLLQDKNEQAVQSAQTIQQLEDQLQQKS 397
Query: 419 KDLVD--KEYVISEKDTXXXXXXXXXXGKDTL------IAQLQ-----LEHQQHMEGPSL 465
K++ + + +T + T IA LQ LE+++ S
Sbjct: 398 KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSS 457
Query: 466 IHV----GTNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEID 520
I + N + ++I ++ Q + E + E+ ++++ D+ K S+ E+ Q D ++
Sbjct: 458 IELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ--DVLE 515
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
K S L++K+ Q+ I F K+ K E+ L QK + E +G
Sbjct: 516 NTFSQKHKELSVLLLEMKEAQEEIA-FLKLQLQGKRAEEADHEV--LDQKEMKQMEGEGI 572
Query: 581 LQLHLVDY--DSGR----MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQ 634
+ + + D+G+ M + +E E A T ++ + E D EL +
Sbjct: 573 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ-ASTEHQSRTSEEISLNDAGVELKSTK 631
Query: 635 QKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG 694
Q D+ + DI Q D++ +KS LE +++ A + + E K + L
Sbjct: 632 QDGDKSLSAVPDIGQCHQDEL-ERLKSQILELELNFHKAQEIYEKNLDEKAK-EISNLNQ 689
Query: 695 TIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE----QSKIQTQ 750
I++ + + ++ + +E L +++++S ++EL A++ E +++ Q +
Sbjct: 690 LIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM--VTELRAQVKQLEMNLAEAERQRR 747
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQ 810
+++ +L E I S + KS+ ++E ++D + ++ + S + Q
Sbjct: 748 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ 807
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLS 870
SE ++ E V ++ VE+ + + E+ K +Q+LLE+ ++++
Sbjct: 808 NKESE-VLEGAERVRHIS------SKVEELSQALSQKELEITKMDQLLLEKKRDVET--- 857
Query: 871 DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL--KRITHEHQTLIVQKKKEIEDL 928
+QQ + EK + T+ QL + + +L + T + Q ++ + +E +
Sbjct: 858 -LQQ---TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKE 913
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM-NVEELNKMNLE 987
++E + ++ S ++ + Y+ E + +E ++ + L N + K+
Sbjct: 914 QVEEDNEVSSGLK------QNYD---EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 964
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
LI++ Q+ + E+ N ++ + + E + + N + S + S +
Sbjct: 965 LINRKELLQRVSRLE--EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQ 1022
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIP 1107
+ E E+Q + K L + E+ Q LV++ + +++ + I
Sbjct: 1023 EIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1082
Query: 1108 KTEGMI---ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + +I I+S + D+ + + E ++ L+++ +L
Sbjct: 1083 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQL 1142
Query: 1165 NTELQECYT--KIIQLETLNTELTGHDVVNQEQ--INQLKSKLEQLNTENDNLLSTVAEL 1220
+LQE T K I + E + + Q++ N+L+ + ++ + EN+N+ + +L
Sbjct: 1143 QKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1202
Query: 1221 RSSISSAVDQR--GFEIAELWKQHLAQREADFQKTEHE-----LRVQLSAFESKYEQLLD 1273
+ + ++D + + E E F+ TE L L + +
Sbjct: 1203 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1262
Query: 1274 SVQSSTQEETNKIVTME---QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
++Q T K E + L+ K+ L E+ + QI EIE
Sbjct: 1263 ALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESL 1322
Query: 1331 KVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXX 1390
K + E+ + + + + + +L+K
Sbjct: 1323 KTV------SHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSY 1376
Query: 1391 XXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE-FENVRQQLVEYEKRIE 1449
++++ EA + ++ ++ ++ ++ + H + +DE + ++ +L E +++ E
Sbjct: 1377 LSGQLSEKEAALTKIQTEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1435
Query: 1450 DLTYEKESELAILRLKMHENANHYETMQKESEI-ERVKLIEELNVKITESVS-LNKQVAE 1507
++ E ++ I R + E +++ + E + L ++T+S++ + QV+
Sbjct: 1436 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1495
Query: 1508 LNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
NK + + + L+ + +++T D + L+N +SS + K
Sbjct: 1496 QNKEKDTVLGRL----ALLQEERDKLITEMDR-SLLENQSLSSSCESLK 1539
Score = 42.3 bits (95), Expect = 0.014
Identities = 91/496 (18%), Positives = 207/496 (41%), Gaps = 36/496 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW---KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS 268
E ++++ ++ + + ME + E + L I+S +SSL+ + E+
Sbjct: 2665 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2724
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
++ +EL Q L++ + + E+ + LE N L+K
Sbjct: 2725 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSH---LEKLNQQLLSKDE 2781
Query: 329 ELLEHLNCQIRQTNKELEN---KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+LL HL+ Q+ + ++++ +A++ E + + +K K R+ A SP
Sbjct: 2782 QLL-HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQ-RSAAQPSTSP 2839
Query: 386 WSQLSSE----TLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
S + +L D D+ + E+ L+ +N+++ + + ++
Sbjct: 2840 AEVQSLKKAMSSLQNDRDRLLK--ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF 2897
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN-VKD 500
++ L Q L Q ++ + + ++ +++E +++EQ ++D+ + ++ +++
Sbjct: 2898 QIMQEEL-RQENLSWQHELDQ---LRMEKSSWEIHE-RRMKEQYLMAISDKDQQLSHLQN 2952
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
LI +L+S+ Q L + + L + + ++++DS KEI +
Sbjct: 2953 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLR--TQLNDSLKEIHQK 3010
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAIS 617
+ L+ ++L EEK L + L D Y ++ + E + L+A
Sbjct: 3011 ELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGP 3070
Query: 618 LLESQKFDLVQELHILQQKYD--EVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDA 670
L QE + + +K D E+ + S+ Q Q+C+ + V+ LEE+ D
Sbjct: 3071 LNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQ-QQLCNTRQEVNELRKLLEEERDQ 3129
Query: 671 LSASKKELALVIENLK 686
A++ L++ E ++
Sbjct: 3130 RVAAENALSVAEEQIR 3145
Score = 38.7 bits (86), Expect = 0.17
Identities = 32/163 (19%), Positives = 77/163 (47%), Gaps = 7/163 (4%)
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
T+ E E ++ +L E E+ I L + A + + M+++ + E+ +
Sbjct: 101 TEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ-EKEEF 159
Query: 1488 IEELNVKITESVSLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
I L +++++ + Q++ + + + E+ A+ E++ +++VT D T +Q
Sbjct: 160 ISTLQAQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQK 219
Query: 1547 VRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAEL 1589
+R K+++H ++ GR + +D + +EL A R ++
Sbjct: 220 LRVLQRKLEEH----EESLVGRAQVVD-LLQQELTAAEQRNQI 257
>X64838-1|CAA46050.1| 1427|Homo sapiens restin protein.
Length = 1427
Score = 118 bits (285), Expect = 1e-25
Identities = 215/1070 (20%), Positives = 442/1070 (41%), Gaps = 81/1070 (7%)
Query: 116 KRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDL 175
KRS + + G +T S+ K + + LQ +K + I
Sbjct: 308 KRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI--- 364
Query: 176 QEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE 235
++ + E+D KAT+ + + KM + +EA + E
Sbjct: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADR-E 423
Query: 236 KQRLLKDIESKDVRISSL----EEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXX 291
K LL +E + ++ L EE + + LEH+++ +ELEQ
Sbjct: 424 KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI-KELEQSLLFEKTKADK 482
Query: 292 XXXLAKQSIEPSCEEKT---EIEEKGSLEIANMTELTKKIELLE-----HLNCQIRQTNK 343
+ + + EK+ E+E+ +L + + EL +++E + ++ + Q
Sbjct: 483 LQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 542
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS--SETLNQDTD-- 399
L+ KL T+ + + K+ ++ + + + +LS +E+L +
Sbjct: 543 SLQEKLEVTRTDHQREITSLKEHFGA-REETHQKEIKALYTATEKLSKENESLKSKLEHA 601
Query: 400 KKINKNEIA----KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
K N + IA KLE I S + + + + S+ T I +++L+
Sbjct: 602 NKENSDVIALWKSKLETAIASHQQAMEELKVSFSK---GLGTETAEFAELKTQIEKMRLD 658
Query: 456 HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ-ITQ 514
+Q +E E+ ++ +L + + + K+ +++ + KL AE+Q + +
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE--KENSLEAIRSKLDKAEDQHLVE 716
Query: 515 LNDEIDAANKNMIKVKSNHKLKLK--QMQKTIDNF-SKVSDSNKEIVRLT---------- 561
+ D ++ + IKVK L+ K + K IDNF S++ + ++++ L
Sbjct: 717 MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776
Query: 562 EELHHLSQKVAELEEEKGNLQLHL-VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLE 620
E+ L Q++ E++ +L++ + I ++ + +++ NL E +S +
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN----LSEVS 832
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
K L +EL IL++K+ E ++ + + + V K EEQ + LS+ ++L
Sbjct: 833 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN---KLHQKEEQFNMLSSDLEKLR- 888
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
ENL D E + + E KL+N I E M ++ + EL K
Sbjct: 889 --ENLA-DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 945
Query: 741 HEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
E+ +++ T+ +A ++ + +++E S+ ++ + EE +E + LE+K
Sbjct: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKM 1004
Query: 800 DQLGSYLQEKQKAYSEYTIQ-----EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ-- 852
+ + QE + Y T + E+ L N L+D + ++ E +EL+
Sbjct: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064
Query: 853 KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKRIT 911
+K + Q + ++ M+Q E + + + K Q +L L E+NLK +
Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1124
Query: 912 --HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
++ + L+ + +++E+ E T ++A + + L+ E+N++ +L E +
Sbjct: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1184
Query: 970 NIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
+ + L LN LE+ K K + + I+ +ALL +KD E+ L
Sbjct: 1185 H-QKLEEERSVLNNQLLEM-KKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242
Query: 1030 QKI------NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE-ELQ 1082
++ N + S S+V ES + K++N+E +++ +QL S + + +
Sbjct: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQAD 1302
Query: 1083 ILVREQDDQIKELKETKLTFE---MNIPKTEGMIISSTIEPMSDDANNVD 1129
R Q+ QI L + + ++ M+ + + DD NN D
Sbjct: 1303 EDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1352
Score = 112 bits (269), Expect = 1e-23
Identities = 162/888 (18%), Positives = 369/888 (41%), Gaps = 72/888 (8%)
Query: 714 IQENMD-LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELS 772
++ MD L +E EK+ ELL ++ E++ QF +++E + ++E++
Sbjct: 406 LEAKMDQLRTMVEAADREKV-ELLNQLEEEKRKVEDLQF----RVEEESITKGDLETQTK 460
Query: 773 KYKSRICRLEESIAVMEDRRYSLERKA-DQLGSYLQEKQKAYS---EYTIQEDELVNRLA 828
+RI LE+S+ + + L+R+ D + + EK + + ++ E+
Sbjct: 461 LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRR 520
Query: 829 VLMDHDRVVEKQL-LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
L + + + L + E LQ+K ++ ++Q ++ +++H+ A E +
Sbjct: 521 RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR---EITSLKEHFGAREETHQKEI 577
Query: 888 LAESEST-KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA-IRDKKV 945
A +T K + L+S L+ E+ +I K ++E +E + K
Sbjct: 578 KALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG 637
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
L + + E TQ+E +Y++ IENL + + K ++ + + +
Sbjct: 638 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA----KEMEALRAKLMKVIK 693
Query: 1006 QYINEINKLNALL-KQKDEEIIALNQKINNAQVSYMSM--VSDYESKLAQFTTKLENMEE 1062
+ N + + + L K +D+ ++ + +N Q + + + + ++K + T ++N
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
Query: 1063 EMQRVSKQLLD-------SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
+++ ++LLD S + E++ L ++ + K++K L E N ++ I+
Sbjct: 754 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH--LEIEKNAESSKASSIT 811
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTK 1174
++ N+ L ++E + ++E+ + E++ + +QE K
Sbjct: 812 RELQGRELKLTNLQENLSEVSQVKETL--EKELQILKEKFAEASEEAVSVQRSMQETVNK 869
Query: 1175 IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
+ Q E L+ +E + +++K + + + L+ +L + I+ + G
Sbjct: 870 LHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDN 929
Query: 1235 IAELWKQH--LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
++L K + L +E D + EL+++L+ L S++ T V EQ
Sbjct: 930 SSQLTKMNDELRLKERDVE----ELQLKLTKANENASFLQKSIEDMT-------VKAEQ- 977
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL 1352
S Q + EE + L+ K +D+ ++E ++ ++ K + +L
Sbjct: 978 -SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNL 1036
Query: 1353 RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK 1412
Q E + EEN+ L + +A +++ Q+ +
Sbjct: 1037 ----QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQMTKE 1090
Query: 1413 DSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANH 1472
+E + T + +E + +++ + K +E+L KE L + KM E
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNL---KNVEELNKSKEL-LTVENQKMEEFRKE 1146
Query: 1473 YETMQKES--EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
ET+++ + + +++ ++E NVK+ E + ++ ++ LEEE + N ++ +E
Sbjct: 1147 IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1206
Query: 1531 IEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ + DE + +QK +S S +D +L+ N+
Sbjct: 1207 SKFIKDADE----------EKASLQKSISITSALLTEKDAELEKLRNE 1244
Score = 98.3 bits (234), Expect = 2e-19
Identities = 191/1015 (18%), Positives = 429/1015 (42%), Gaps = 91/1015 (8%)
Query: 358 AVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
A +S S K SP S S ++ + S S+ S L +T + + +I+ + ++L
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVS--SRPSRTGLLTETSSRYAR-KISGTTALQEAL 357
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ E +++E+D + +L L H + ++ + + +
Sbjct: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ--HVLELEAKMDQLRT 415
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQ--LNDEIDAANKNMIKVKSN--- 532
+ + ++ K EL +++++ K + + EE IT+ L + + + +++ +
Sbjct: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLF 475
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKE-IVRLTEELHHLSQKVAELEEE-KGNLQLHLVDYDS 590
K K ++Q+ +++ + S K I+ L ++L Q+VAEL + N VD
Sbjct: 476 EKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL 535
Query: 591 GRMIESDVYKKMIEMENL----------------AETRLKAISLLESQKFDLVQELHILQ 634
+ E ++ +E+ ET K I L + L +E L+
Sbjct: 536 SLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK 595
Query: 635 QKYDEVEDKLADI-----SQLQ----SDQVCSEIKSVHLEEQIDALSASKKELALVIENL 685
K + + +D+ S+L+ S Q E V + + +A EL IE +
Sbjct: 596 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM 655
Query: 686 KLDKEQLYGTIKDLENDK--------EDIMNKLQNYIQENMD----LTDKLEKMSAEKIS 733
+LD + +++ ++ + E + KL I+E + + KL+K + +
Sbjct: 656 RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV 715
Query: 734 ELLAKIN--HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE-------ES 784
E+ +N E + K++ + AK E+ I+N S+L + ++ L+ E
Sbjct: 716 EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG 775
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ M+ R LE Q+ EK S+ + EL R L + +++ L E+
Sbjct: 776 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN----LQENLSEV 831
Query: 845 EHENKELQKKNQILLE---ENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ L+K+ QIL E E +S+ MQ+ N L +K + ++ S+ K + L
Sbjct: 832 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 891
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
D+E+ + + LI K+K D+ +++ + K +N++ V +L
Sbjct: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK-MNDELRLKERDVEEL 950
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
+ +L + N L ++E++ + E + K+ + E+ ++++ K
Sbjct: 951 QLKLTKANENASFLQKSIEDMT-VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009
Query: 1021 KDEEIIALNQK-INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
+ +E+ A ++ + + + ++ + + L KL+ EE + ++L + ++ +
Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD 1069
Query: 1080 ELQILVREQDD-QIKE---LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+ + +D QI E ++T+ + K + + ++ + ++ N +
Sbjct: 1070 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN-NLKNVEELNK 1128
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNTELTGHDVV 1191
++ Q+ EEF +E L++ +A+ + + LQE K+ +L E+T H +
Sbjct: 1129 SKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1188
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ 1251
+E+ + L ++L ++ + E ++S+ ++ + L +++A+ +
Sbjct: 1189 EEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSI--------SITSALLTEKDAELE 1239
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
K +E+ V L + + L VQ+ E++K+ +V +L+ +L++ + L
Sbjct: 1240 KLRNEVTV-LRGENASAKSLHSVVQTL---ESDKVKLELKVKNLELQLKENKRQL 1290
Score = 66.9 bits (156), Expect = 6e-10
Identities = 121/612 (19%), Positives = 250/612 (40%), Gaps = 56/612 (9%)
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+Q+ + + EQ + E + A + + + + Q++ A+ + V + E+K+ Q
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK-ETKLTFEMNIPKTEG 1111
T +E + E + QL + K+ E+LQ V E+ +L+ +TKL I + E
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE-HARIKELEQ 471
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF-IQERSVLQE--QSAKLNTEL 1168
++ + D ++++++ +QE + L+ +S K ++
Sbjct: 472 SLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV 531
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLK-----------SKLEQLNTENDNLLSTV 1217
+ + ++ +L +L +Q +I LK +++ L T + L
Sbjct: 532 DMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKEN 591
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQS 1277
L+S + A ++ ++ LWK L A Q+ EL+V S + + + +
Sbjct: 592 ESLKSKLEHA-NKENSDVIALWKSKLETAIASHQQAMEELKVSFS--KGLGTETAEFAEL 648
Query: 1278 STQEETNKIVTMEQVTSLQNKLQDKE-----EHLRNLQEKYADVI----NQIEILRSEI- 1327
TQ E ++ ++ +LQN+ QD E + + L+ K VI N +E +RS++
Sbjct: 649 KTQIEKMRLDYQHEIENLQNQ-QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 707
Query: 1328 --EDEKVAFXXXXXXXXXXXXXXXXDLRTE----NQSYKQMQE-QSILNINEENA----Q 1376
ED+ + +L N+ K + S L EE
Sbjct: 708 KAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 767
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKV--LELTHQLE-LKDSEIYQKTHEYTITLTQRNDE 1433
L+K+S ++ AE ++ LE+ E K S I ++ + LT +
Sbjct: 768 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN 827
Query: 1434 FENVRQQLVEYEKRIEDL--TYEKESELAI-LRLKMHENANHYETMQKE-----SEIERV 1485
V Q EK ++ L + + SE A+ ++ M E N +++ S++E++
Sbjct: 828 LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887
Query: 1486 K-LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+ + ++ K E +Q+ + + LE ++A+ +M + ++ +NDE+ +
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS---GDNSSQLTKMNDELRLKE 944
Query: 1545 NMVRASSSKIQK 1556
V K+ K
Sbjct: 945 RDVEELQLKLTK 956
Score = 58.4 bits (135), Expect = 2e-07
Identities = 132/690 (19%), Positives = 279/690 (40%), Gaps = 75/690 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMK--------IMETTILDLQE-------------KINEKDQI 185
L IKEK+N+L ++ K+ ME T+ LQE K NE+ ++
Sbjct: 688 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 747
Query: 186 IE---AKNKATTXXXXXXXXXXXXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQR- 238
I+ ++ KAT + K QQ+ ++ +E E E +
Sbjct: 748 IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
Query: 239 --LLKDIESKDVRISSLE----EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXX 292
+ ++++ +++++++L+ E +++ E E+ + K A+ E+
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867
Query: 293 XXLAKQ---------SIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK 343
L ++ +E E ++E K + +L K E LE+ +I + +
Sbjct: 868 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 927
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+ ++L M E + + + L K+ N + KS +Q K +
Sbjct: 928 DNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 986
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXXXXXXXGKDTLIAQLQ---LEHQQH 459
+ E +LE + L K + E K + ++ LQ L+ +
Sbjct: 987 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1046
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLK--QELND--EIKDVNVKDLIEKLKSAE---EQI 512
++G + G +++ E+ K ++ K Q D +I + K+ E L S E +
Sbjct: 1047 LKGAREENSGL-LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1105
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
+L +E+D +N +K+ +L + T++N K+ + KEI L + SQ+++
Sbjct: 1106 AKLQNELDTLKEN--NLKNVEELNKSKELLTVEN-QKMEEFRKEIETLKQAAAQKSQQLS 1162
Query: 573 ELEEEKGNLQLHLVDYDSGR-MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
L+EE L L GR E ++K+ E ++ +L + ES+ E
Sbjct: 1163 ALQEENVKLAEEL-----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217
Query: 632 ILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
QK + L + +++ +E+ + E +AS K L V++ L+ DK +
Sbjct: 1218 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------NASAKSLHSVVQTLESDKVK 1271
Query: 692 LYGTIKDLENDKEDIMNKLQN---YIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KI 747
L +K+LE ++ +L + D ++ ++ + ++ ++ + + Q K+
Sbjct: 1272 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1331
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSR 777
+ + +A + + N +S+ + +S+
Sbjct: 1332 KVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1361
Score = 49.2 bits (112), Expect = 1e-04
Identities = 105/582 (18%), Positives = 225/582 (38%), Gaps = 32/582 (5%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+ HL + + S + +++ E + +LQE ++E Q+ E K
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
++ + K+ + + ++L +++ + + +E + L A
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNM-LSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
Query: 264 RFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+ ++ + +++ ++ L ++ +E + T+ E S ++ +
Sbjct: 912 KEKLENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
Query: 324 LTKKIELLEHLNC-QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+T K E + + + KELE KL+ + + + + ++ R + T +K
Sbjct: 971 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS-ETKTKH 1029
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ L L+ + K + E + L ++ L K DK +
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-ADKAKAAQTAEDAMQIMEQMT 1088
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHV--GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD 500
K +A L+ Q + + + + N ++V E+ K +E L E N ++++ +
Sbjct: 1089 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE-NQKMEEFRKE- 1146
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
IE LK A Q +Q + N + + + ++ QK + S +++ +L
Sbjct: 1147 -IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN------QL 1199
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK-------MIEMENLAETRL 613
E S+ + + +EEK +LQ + S + E D + ++ EN + L
Sbjct: 1200 LEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL 1258
Query: 614 -KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
+ LES K L ++ L+ + E + +L+ S Q + ++ E QID L+
Sbjct: 1259 HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA--QESQIDFLN 1316
Query: 673 ASKKELALVIENLKLDKEQ-----LYGTIKDLENDKEDIMNK 709
+ +L ++LK+ E L G DL N D K
Sbjct: 1317 SVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEK 1358
>X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 AA)
protein.
Length = 1167
Score = 118 bits (284), Expect = 2e-25
Identities = 213/1105 (19%), Positives = 457/1105 (41%), Gaps = 77/1105 (6%)
Query: 471 NTEDVNEIAKVQEQLKQELNDEI--KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
+ E E+A ++E+ Q+ DE+ + K+L EKL + ++ L ++ A ++N++
Sbjct: 70 SAETEKEMATMKEEF-QKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 128
Query: 529 VKS--NHKLKLK-QMQKTIDNFSKVSDSNKEI-VRLTEELHHLSQKVAELEEEKGNLQLH 584
+ + +K K Q++ I ++ ++ +EI LT + L + +EL+++ +L+L
Sbjct: 129 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 188
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
L +E + + +++NL E +S L+ L +E LQ+ + + D L
Sbjct: 189 LAK------VEKEKHATENKVKNLTEE----LSGLDETIAKLTREKKALQEAHQQALDDL 238
Query: 645 ADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIK------ 697
Q + D+V S K+ LE+Q++ L +S ++ + +L+ +K +L G +K
Sbjct: 239 ----QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI 294
Query: 698 -DLENDKEDIMNKLQNYIQENMDLTDKLEKMSA------EKISELLAKINHEEQSKIQTQ 750
DLENDK+ + +L+ E L K+E +KI EL A+I E+ +I+ +
Sbjct: 295 LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEE-EIEAE 353
Query: 751 FGIDAKIQ-ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS--LERKADQLGSYLQ 807
AK + +R Y +E ELS+ + + + +R + L+ + D + LQ
Sbjct: 354 RATRAKTEKQRSDYARELE-ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ 412
Query: 808 EKQKAYSEYTIQED---ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
+ + D EL ++ L + +EK+ E + E +L + + + N
Sbjct: 413 HEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKAN 472
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---K 921
L+ ++ + K + SE T +++L+ L R E ++++ Q
Sbjct: 473 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 532
Query: 922 KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
K+ E Q+E + K L + + L Q +E + L L
Sbjct: 533 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ---RAL 589
Query: 982 NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
+K N E+ K +T + TE+ KL L+ +E++ A+N K + + +
Sbjct: 590 SKANSEVAQWRT-KYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQR 648
Query: 1042 MVSDYESKLAQF---TTKLENMEEEMQRVSKQLLDSKQHNEE----LQILVREQDDQIKE 1094
+ + E + + ++++ + K L + K EE L+ ++E E
Sbjct: 649 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE 708
Query: 1095 LKETKLTFEMNIPKTEGMIISS-TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
L + K +E + + E + + +E D + Q E E
Sbjct: 709 LFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADI 768
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ-LNTENDN 1212
+ L+E A L E + ++L + +E+ E+I QLK ++ + T
Sbjct: 769 QLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 828
Query: 1213 LLSTVAELRSSISSAVDQRG-FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
L + V +I G E+ H ++ A+ K ++ QL + +
Sbjct: 829 LDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA 888
Query: 1272 LDSVQSSTQE----ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE- 1326
L + + ++ E + +V L+ L+ E + +++ D ++++L ++
Sbjct: 889 LQTQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 948
Query: 1327 --IEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ------MQEQSILNINEENAQLK 1378
+ K D R + K+ M + + + +A L+
Sbjct: 949 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1008
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVR 1438
+ R+++AE L+ + +++ E + E+ + Q+ + E+V+
Sbjct: 1009 RMKKNLEQTVKDLQHRLDEAEQLALK-GGKKQIQKLETRIRELEFELEGEQKKNT-ESVK 1066
Query: 1439 QQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITES 1498
L +YE+R+++LTY+ E + + L++ + + + K + + + E+ N +T+
Sbjct: 1067 G-LRKYERRVKELTYQSEEDRKNV-LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKF 1124
Query: 1499 VSLNKQVAELNKALEEEVAKTNEMQ 1523
++ E + + ++ N+++
Sbjct: 1125 RKAQHELEEAEERADIAESQVNKLR 1149
Score = 118 bits (283), Expect = 2e-25
Identities = 204/1113 (18%), Positives = 471/1113 (42%), Gaps = 99/1113 (8%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEEL-------HHLSQKVAELEEEKGNLQLHLVDY 588
K+K + K+ + +++ +E + +EL L +K+ L +EK +LQL V
Sbjct: 63 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ-VQA 121
Query: 589 DSGRMIESDV-YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD--------E 639
+S +++++ ++I+ + E ++K ++ + ++ EL ++K + +
Sbjct: 122 ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 181
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL 699
++D +++++ ++ +E K +L E++ L + +L + L+ +Q ++
Sbjct: 182 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ-A 240
Query: 700 ENDKEDIMNKLQNYIQENM-DLTDKLEKMSAEKIS------ELLAKINHEEQSKIQTQFG 752
E DK + +NK ++ +++ + DL LE+ ++ +L + ++S + +
Sbjct: 241 EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 300
Query: 753 ---IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
+D +++++D ++S++ ++ + ++ I ++ R LE + + + +
Sbjct: 301 KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKT 360
Query: 810 QKAYSEYTIQEDELVNRL-------AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+K S+Y + +EL RL + ++ ++ E + L++ + +E +++ ++
Sbjct: 361 EKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV--- 417
Query: 863 QNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESNLKRITHEH------- 914
L+ +D ++ R E E ++++ ++ DL S+++ ++
Sbjct: 418 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 477
Query: 915 QTLIVQ------KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+TL Q K +EI+ E TQ + L+ + E+ V+QL Q +
Sbjct: 478 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 537
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN---KLNALLKQKDEEI 1025
E L +EE NK L +Q + EQY E +L L + + E+
Sbjct: 538 QQTEELKRQLEEENKAKNALAHA-LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 596
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQ----HN 1078
K + + + + KLAQ +L++ EE+++ V+ + L +KQ
Sbjct: 597 AQWRTKYETDAIQRTEELEEAQEKLAQ---RLQDSEEQVEAVNAKCASLEKTKQRLQGEV 653
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIP--KTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
E+L + V + L + + F+ + KT+ + +E ++ ++
Sbjct: 654 EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLK 713
Query: 1137 XXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQI 1196
+ + E +E L+++ A L ++ E I +LE ++ Q +
Sbjct: 714 NAYEE-ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 772
Query: 1197 NQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHE 1256
+ ++ LE + + + +++S I + ++ EI +L + + E + E
Sbjct: 773 EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE 832
Query: 1257 LRVQLSA--FESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQNKLQDKEEHL------- 1306
+R + A + K E L+ ++ + T++ + S+Q +L+D + HL
Sbjct: 833 VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALQTQ 892
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD------LRTENQSYK 1360
+L+E+ A V + +L++E+E+ + L T+N S
Sbjct: 893 EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLI 952
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQK 1419
+++ ++ + ++++ +S + DA EL + + E +K
Sbjct: 953 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1012
Query: 1420 THEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHE 1468
E T+ L R DE E + ++Q+ + E RI +L +E E E ++ L+ +E
Sbjct: 1013 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1072
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALE 1527
T Q E + + V +++L K+ V S +Q E ++ + K + Q LE
Sbjct: 1073 RRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1132
Query: 1528 NQEIEIVTLNDEITNLQNMVR-ASSSKIQKHVS 1559
E ++ L+ R +SS++ H S
Sbjct: 1133 EAEERADIAESQVNKLRAKTRDFTSSRMVVHES 1165
Score = 103 bits (248), Expect = 4e-21
Identities = 184/934 (19%), Positives = 405/934 (43%), Gaps = 78/934 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLE--AARFEISLE 270
++++ + E + E K + Q+ L D+++++ +++SL + LE E SLE
Sbjct: 208 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 267
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++SI +K +++E+ + +L K+E
Sbjct: 268 QEKKLRVDLERNKRKLEGDLK----LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 323
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q ++ KEL+ ++ + E +A + K + K + A +++ +L
Sbjct: 324 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-----TEKQRSDYARELEELSERL 378
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS--EKDTXXXXXXXXXXGKDT 447
T ++NK A+ + + L + + E +++ K +
Sbjct: 379 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNL 438
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKL 505
+ +LE ++ + + ++ E V++ E++ + L D++ + K ++ L
Sbjct: 439 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 498
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQ--MQKTIDNFSKVSDSNKEIVRLT 561
Q ++L E ++ + + +S + + KQ Q+T + ++ + NK L
Sbjct: 499 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 558
Query: 562 EELHH-------LSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMIEMENLA 609
L L ++ E +E K LQ L +S E+D ++ E+E
Sbjct: 559 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQ 618
Query: 610 ETRLKAISLLESQKFDLVQELHIL----QQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
E + + E Q + + L Q+ EVED + D+ + S + K + +
Sbjct: 619 EKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 678
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
+ + +E +E + L + L+N E+ +++L+ +EN +L ++
Sbjct: 679 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 738
Query: 726 KMSAEKISELLAKINHEEQSKIQTQF---GIDAKIQERDLYIEN-------IESELSKYK 775
++ E+I+E I+ E+S+ Q + I ++E + +E+ I+ EL++ K
Sbjct: 739 DLT-EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 797
Query: 776 SRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLM 831
S I R + E +E + + +R + + S L + ++ +E + ++ +N + + +
Sbjct: 798 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 857
Query: 832 DH--DRVVE--KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--R 885
H + E K L ++ + K+ Q L+ ++L+ L+ +++ N L + R
Sbjct: 858 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALQTQEDLKEQLAIVERRANLLQAEVEELR 917
Query: 886 TDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
L ++E + + L+SN + ++ H T ++ KK++E ++ +++E A RD +
Sbjct: 918 ATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 977
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
EK +K I + +L++ ++ +L E K NLE K +Q + ++
Sbjct: 978 NAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQLA 1032
Query: 1005 -EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ +I KL +++ + E+ QK N V + YE ++ + T + E +
Sbjct: 1033 LKGGKKQIQKLETRIRELEFELEG-EQKKNTESVKGL---RKYERRVKELTYQSEEDRKN 1088
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ R+ + L+D +LQ+ V+ Q +E E
Sbjct: 1089 VLRL-QDLVD------KLQVKVKSYKRQAEEADE 1115
Score = 101 bits (243), Expect = 2e-20
Identities = 180/969 (18%), Positives = 400/969 (41%), Gaps = 54/969 (5%)
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+KS ++ T+ ++ K K+E+AK E + L + LV ++
Sbjct: 68 LKSAETEKEMATMKEEFQK--TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESEN 125
Query: 442 XXGKDTLIAQL-QLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQLKQELNDEIKDVNVK 499
+ QL + + Q + + + E++N E+ + +L+ E ++ KD++
Sbjct: 126 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 185
Query: 500 DL----IEKLKSA-EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
+L +EK K A E ++ L +E+ ++ + K+ K + Q+ +D+ D
Sbjct: 186 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED-- 243
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETRL 613
++ L + L Q+V +LE + VD + R +E D+ + +L +
Sbjct: 244 -KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 302
Query: 614 KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA 673
+ L+ + F+ Q LQ K VED+ Q Q + + LEE+I+A A
Sbjct: 303 QLDERLKKKDFEYCQ----LQSK---VEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 355
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
++ + + + E+L +++ + + E + L LE+ + +
Sbjct: 356 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH-E 414
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++A + + + + +I + +E E S++K I L S+ + +
Sbjct: 415 AMVATLRKKHADSVAE---LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 471
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
+LE+ L L E + E EL + + L + +QL E E +L +
Sbjct: 472 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 531
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRIT 911
Q ++ + L+ L + + NAL +++R D + +Y+ + ++ ++ L+R
Sbjct: 532 SKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD-CDLLREQYEEE-QEGKAELQRAL 589
Query: 912 HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV----TQLEAQLQEY 967
+ + + Q + + E I+ ++E A + E+ +E V LE Q
Sbjct: 590 SKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRL 649
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +E+L ++VE N + L K+Q ++ + + A L+ +E +
Sbjct: 650 QGEVEDLMVDVERANSLAAAL-----DKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 704
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVRE 1087
L+ ++ + +Y + E+ + +N+E+E+ +++Q+ ++ + EL+ ++
Sbjct: 705 LSTELFKLKNAYEEALDQLET----VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 760
Query: 1088 QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE 1147
+ + +++ E + E I+ +E ++ + +D LK +
Sbjct: 761 IELEKADIQLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRKIAEKDEEIEQLKRNYQ 819
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS---KLE 1204
+S L + N ++ L + +L+ + E + L+S +L+
Sbjct: 820 RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 879
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE--HELRVQLS 1262
D+ L T +L+ + + V++R A L + + + A ++TE +L Q
Sbjct: 880 DTQLHLDDALQTQEDLKEQL-AIVERR----ANLLQAEVEELRATLEQTERARKLAEQEL 934
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
++ QLL + +S K+ T + LQ++++D RN +EK I +
Sbjct: 935 LDSNERVQLLHTQNTSLIHTKKKLET--DLMQLQSEVEDASRDARNAEEKAKKAITDAAM 992
Query: 1323 LRSEIEDEK 1331
+ E++ E+
Sbjct: 993 MAEELKKEQ 1001
Score = 99 bits (238), Expect = 7e-20
Identities = 198/1034 (19%), Positives = 435/1034 (42%), Gaps = 105/1034 (10%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 71 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 130
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K + + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 131 ERCDQLIKAKFQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 189
Query: 350 ATMGTESKAVSSPSKKGSPLIS------RKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
A + E A + K + +S K R + ++ L +D +N
Sbjct: 190 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 249
Query: 404 KNEIAKLEMVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLI----AQLQLEHQQ 458
K + +KLE ++ L L +K+ + + +++++ + QL+ +
Sbjct: 250 KTK-SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERL 308
Query: 459 HMEGPSLIHVGTNTEDVNEIA-KVQEQLK------QELNDEIK-DVNVKDLIEKLKS-AE 509
+ + + ED + + Q+++K +EL +EI+ + + EK +S
Sbjct: 309 KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYA 368
Query: 510 EQITQLNDEI-DAANKNMIKVKSNHK-----LKLKQ--MQKTIDNFSKVSDSNKE----I 557
++ +L++ + +A +++ N K LKL++ + T+ + + V+ K+ +
Sbjct: 369 RELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSV 428
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM-----ENLAETR 612
L E++ +L + +LE+EK +L + D S S + ++ + L+E R
Sbjct: 429 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR 488
Query: 613 LK------AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
K ++S L +QK L E L + ++E+K + +SQL + ++ L+
Sbjct: 489 GKNEEIQRSLSELTTQKSRLQTEAGELSR---QLEEKESIVSQLSRSKQAFTQQTEELKR 545
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
Q++ + +K LA +++ + D + L ++ + K ++ L E K E
Sbjct: 546 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 605
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ ++ EL E Q K+ ++Q+ + +E + ++ + + RL+ +
Sbjct: 606 DAIQRTEEL-----EEAQEKLA------QRLQDSEEQVEAVNAKCASLEKTKQRLQGEV- 653
Query: 787 VMEDRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
ED +ER A+ L + L +KQ K +E+ + +E L + R + +L
Sbjct: 654 --EDLMVDVER-ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 710
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHY----NALVEKANRTDLAESESTKYQT 898
++++ +E + + + EN+NL+ ++D+ + + E E E Q
Sbjct: 711 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 770
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV- 957
L + E+ L+ HE + I++ + E+ ++ E + +I + + L Y++ +E +
Sbjct: 771 ALEEAEAALE---HE-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 826
Query: 958 TQLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ L+A+++ +N L +E +LN++ ++L H +Q ++ + ++
Sbjct: 827 SALDAEVRS-RNEAIRLKKKMEGDLNEIEIQL--SHANRQAAETLKHLRSVQGQLKDTQL 883
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
L ++ + + + + ++++ + LE E + ++LLDS
Sbjct: 884 HL----DDALQTQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS-- 937
Query: 1077 HNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
NE +Q+L Q L TK E T+ M + S +E S DA N +
Sbjct: 938 -NERVQLL----HTQNTSLIHTKKKLE-----TDLMQLQSEVEDASRDARNAEEKAKKAI 987
Query: 1137 XXXXXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ 1195
+ + ++E Q+ S L+ L +++ ++ + E L L G ++Q
Sbjct: 988 TDAAMMAEELKKE--QDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKG----GKKQ 1039
Query: 1196 INQLKSKLEQLNTE 1209
I +L++++ +L E
Sbjct: 1040 IQKLETRIRELEFE 1053
Score = 87.0 bits (206), Expect = 5e-16
Identities = 161/839 (19%), Positives = 341/839 (40%), Gaps = 88/839 (10%)
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
K E + + ++ E K K + + E +E++ +L ++ + L +Q + + +
Sbjct: 69 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 128
Query: 816 YTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQH 875
+ D+L+ L + V ++ + E N EL K + L +E L+ + D++
Sbjct: 129 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 188
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
A VEK E++ +L L+ + ++T E + L ++ ++DL+ E
Sbjct: 189 L-AKVEKEKHA--TENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE---- 241
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQK 995
E + K E+ +E LE+ L++ K +L N +L +L+L + +
Sbjct: 242 -EDKVNSLNKTKSKLEQQVE---DLESSLEQEKKLRVDLERNKRKLEG-DLKLAQESILD 296
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ N+ +L+ LK+KD E L K+ + Q ++ ++ K+ +
Sbjct: 297 LE-----------NDKQQLDERLKKKDFEYCQLQSKVEDEQ----TLGLQFQKKIKELQA 341
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
++E +EEE++ +++ +K +++ D +EL+E E G + S
Sbjct: 342 RIEELEEEIE--AERATRAKTE--------KQRSDYARELEELSERLE-----EAGGVTS 386
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI 1175
+ IE L+ EE +Q +++ K + E +I
Sbjct: 387 TQIE-----------LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQI 435
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
L+ + +L + +I+ L S +E ++ NL L +S A + E
Sbjct: 436 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN--EE 493
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSL 1295
+ L +++ Q EL QL ES QL S Q+ TQ Q L
Sbjct: 494 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ----------QTEEL 543
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
+ +L+++ + L + ++LR + E+E+ RT+
Sbjct: 544 KRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG-KAELQRALSKANSEVAQWRTK 602
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
++ + + + E+ AQ + S + + ++ Q E++D
Sbjct: 603 YETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRL-----QGEVEDLM 657
Query: 1416 I-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELA---ILRLKMHENAN 1471
+ ++ + L ++ F+ V L E++ + E+ E E+ L L ++ + N
Sbjct: 658 VDVERANSLAAALDKKQRNFDKV---LAEWKTKCEESQAELEASLKESRSLSTELFKLKN 714
Query: 1472 HYETM--QKESEIERVKLIEELNVKITESVSLN-KQVAELNKALEE-EVAKTN------E 1521
YE Q E+ K +E+ +TE ++ N K + EL K+ ++ E+ K + E
Sbjct: 715 AYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEE 774
Query: 1522 MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
+ ALE++E +I+ + E+T +++ + ++ + + Q E + + ++ E+
Sbjct: 775 AEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 833
Score = 77.0 bits (181), Expect = 5e-13
Identities = 185/927 (19%), Positives = 373/927 (40%), Gaps = 94/927 (10%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD LQ K++ +T L Q+KI E IE +
Sbjct: 300 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 359
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E + + K+R + E +R LEEA EA
Sbjct: 360 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLR-RDLEEATLQHEA 415
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEE-KGSLEIAN 320
+ +H+ EL + KQ +E E K EI++ S+E +
Sbjct: 416 MVATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEFKLEIDDLSSSMESVS 467
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKSGRN 377
++ L K LE + R N+E++ L+ + T+ S+ + + L ++S +
Sbjct: 468 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 527
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q + E Q ++ KN +A + + DL+ ++Y ++
Sbjct: 528 QLSRSKQAFTQQTEELKRQLEEENKAKNALAH-ALQSSRHDCDLLREQYEEEQEGKAELQ 586
Query: 438 XXXXXXGK-----------DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
D + +LE Q L E VN E+ K
Sbjct: 587 RALSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTK 646
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
Q L E++D+ V D+ E+ L +D +N KV + K K ++ Q ++
Sbjct: 647 QRLQGEVEDLMV-DV--------ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 697
Query: 547 FSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM 605
K S S + E+ +L ++ ++ E NL+ + D + ++ E+ K + E+
Sbjct: 698 SLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL-TEQIAENG--KTIHEL 754
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI--KSVH 663
E K+ +E +K D+ L + + E K+ I QL+ QV SEI K
Sbjct: 755 E-------KSRKQIELEKADIQLALEEAEAALEHEEAKILRI-QLELTQVKSEIDRKIAE 806
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK 723
+E+I+ L K+ +E + + L ++ N+ + K++ + E
Sbjct: 807 KDEEIEQL---KRNYQRTVETM---QSALDAEVRS-RNEAIRLKKKMEGDLNEIEIQLSH 859
Query: 724 LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE 783
+ +AE + L + + Q K TQ +D +Q + E+++ +L+ + R L+
Sbjct: 860 ANRQAAETLKHLRSV---QGQLK-DTQLHLDDALQTQ----EDLKEQLAIVERRANLLQ- 910
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
A +E+ R +LE+ + L E++ S +Q L + L+ + +E L++
Sbjct: 911 --AEVEELRATLEQ--TERARKLAEQELLDSNERVQ--LLHTQNTSLIHTKKKLETDLMQ 964
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL 903
++ E ++ + + + + +++D L ++ + + E + ++DL
Sbjct: 965 LQSEVEDASRDAR---NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1021
Query: 904 ESNLKRITHEHQTLIVQKKKEIEDL-----EIEFNTQIESAIRDKKVLN-EKYEKNIEYV 957
+ R+ Q + KK+I+ L E+EF + E + V KYE+ ++
Sbjct: 1022 Q---HRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVK-- 1076
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+L Q +E + N+ L V++ L++ K ++Q ++ + ++ + K
Sbjct: 1077 -ELTYQSEEDRKNVLRLQDLVDK-----LQVKVKSYKRQAEEADEQANAHLTKFRKAQHE 1130
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVS 1044
L++ +E ++N + S
Sbjct: 1131 LEEAEERADIAESQVNKLRAKTRDFTS 1157
Score = 74.1 bits (174), Expect = 4e-12
Identities = 96/457 (21%), Positives = 210/457 (45%), Gaps = 43/457 (9%)
Query: 468 VGTNTEDVNEIAKVQEQLKQELND-----EIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
+ N + ++E+ K ++Q++ E D E + ++ K+ + ++TQ+ EID
Sbjct: 744 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID-- 801
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
K K + +LK + Q+T++ D+ VR E L +K +E + ++
Sbjct: 802 RKIAEKDEEIEQLK-RNYQRTVETMQSALDAE---VRSRNEAIRLKKK---MEGDLNEIE 854
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD---- 638
+ L + + + E+ + + ++ + L +T+L L++Q+ DL ++L I++++ +
Sbjct: 855 IQL-SHANRQAAETLKHLRSVQGQ-LKDTQLHLDDALQTQE-DLKEQLAIVERRANLLQA 911
Query: 639 EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
EVE+ A + Q + + +E + + E++ L L + L+ D QL ++D
Sbjct: 912 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 971
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
D + K + I + + ++L+K + A + +++ QT + ++
Sbjct: 972 ASRDARNAEEKAKKAITDAAMMAEELKKEQ-----DTSAHLERMKKNLEQTVKDLQHRLD 1026
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
E + + L K +I +LE I +E ++K + L++ ++ E T
Sbjct: 1027 EAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTY 1080
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
Q +E +R VL D +V+K ++++ ++ ++ +E N ++ QH
Sbjct: 1081 QSEE--DRKNVLRLQD-LVDKLQVKVKSYKRQAEEA-----DEQANAHLTKFRKAQH--E 1130
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
L E R D+AES+ K + + RD S+ + + HE +
Sbjct: 1131 LEEAEERADIAESQVNKLRAKTRDFTSS-RMVVHESE 1166
>X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for
embryonic myosin heavy chain. ).
Length = 1940
Score = 118 bits (283), Expect = 2e-25
Identities = 204/1113 (18%), Positives = 471/1113 (42%), Gaps = 99/1113 (8%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEEL-------HHLSQKVAELEEEKGNLQLHLVDY 588
K+K + K+ + +++ +E + +EL L +K+ L +EK +LQL V
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ-VQA 894
Query: 589 DSGRMIESDV-YKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD--------E 639
+S +++++ ++I+ + E ++K ++ + ++ EL ++K + +
Sbjct: 895 ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 954
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL 699
++D +++++ ++ +E K +L E++ L + +L + L+ +Q ++
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ-A 1013
Query: 700 ENDKEDIMNKLQNYIQENM-DLTDKLEKMSAEKIS------ELLAKINHEEQSKIQTQFG 752
E DK + +NK ++ +++ + DL LE+ ++ +L + ++S + +
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Query: 753 ---IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
+D +++++D ++S++ ++ + ++ I ++ R LE + + + +
Sbjct: 1074 KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKT 1133
Query: 810 QKAYSEYTIQEDELVNRL-------AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+K S+Y + +EL RL + ++ ++ E + L++ + +E +++ ++
Sbjct: 1134 EKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV--- 1190
Query: 863 QNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESNLKRITHEH------- 914
L+ +D ++ R E E ++++ ++ DL S+++ ++
Sbjct: 1191 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 1250
Query: 915 QTLIVQ------KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+TL Q K +EI+ E TQ + L+ + E+ V+QL Q +
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN---KLNALLKQKDEEI 1025
E L +EE NK L +Q + EQY E +L L + + E+
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHA-LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1369
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQ----HN 1078
K + + + + KLAQ +L++ EE+++ V+ + L +KQ
Sbjct: 1370 AQWRTKYETDAIQRTEELEEAQEKLAQ---RLQDSEEQVEAVNAKCASLEKTKQRLQGEV 1426
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIP--KTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
E+L + V + L + + F+ + KT+ + +E ++ ++
Sbjct: 1427 EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLK 1486
Query: 1137 XXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQI 1196
+ + E +E L+++ A L ++ E I +LE ++ Q +
Sbjct: 1487 NAYEE-ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545
Query: 1197 NQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHE 1256
+ ++ LE + + + +++S I + ++ EI +L + + E + E
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE 1605
Query: 1257 LRVQLSA--FESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQNKLQDKEEHL------- 1306
+R + A + K E L+ ++ + T++ + S+Q +L+D + HL
Sbjct: 1606 VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQ 1665
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD------LRTENQSYK 1360
+L+E+ A V + +L++E+E+ + L T+N S
Sbjct: 1666 EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLI 1725
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQK 1419
+++ ++ + ++++ +S + DA EL + + E +K
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Query: 1420 THEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHE 1468
E T+ L R DE E + ++Q+ + E RI +L +E E E ++ L+ +E
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALE 1527
T Q E + + V +++L K+ V S +Q E ++ + K + Q LE
Sbjct: 1846 RRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905
Query: 1528 NQEIEIVTLNDEITNLQNMVR-ASSSKIQKHVS 1559
E ++ L+ R +SS++ H S
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSRMVVHES 1938
Score = 117 bits (281), Expect = 4e-25
Identities = 213/1105 (19%), Positives = 456/1105 (41%), Gaps = 77/1105 (6%)
Query: 471 NTEDVNEIAKVQEQLKQELNDEI--KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
+ E E+A ++E+ Q+ DE+ + K+L EKL + ++ L ++ A ++N++
Sbjct: 843 SAETEKEMATMKEEF-QKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 529 VKS--NHKLKLK-QMQKTIDNFSKVSDSNKEI-VRLTEELHHLSQKVAELEEEKGNLQLH 584
+ + +K K Q++ I ++ ++ +EI LT + L + +EL+++ +L+L
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
L +E + + +++NL E +S L+ L +E LQ+ + + D L
Sbjct: 962 LAK------VEKEKHATENKVKNLTEE----LSGLDETIAKLTREKKALQEAHQQALDDL 1011
Query: 645 ADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIK------ 697
Q + D+V S K+ LE+Q++ L +S ++ + +L+ +K +L G +K
Sbjct: 1012 ----QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI 1067
Query: 698 -DLENDKEDIMNKLQNYIQENMDLTDKLEKMSA------EKISELLAKINHEEQSKIQTQ 750
DLENDK+ + +L+ E L K+E +KI EL A+I E+ +I+ +
Sbjct: 1068 LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEE-EIEAE 1126
Query: 751 FGIDAKIQ-ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS--LERKADQLGSYLQ 807
AK + +R Y +E ELS+ + + + +R + L+ + D + LQ
Sbjct: 1127 RATRAKTEKQRSDYARELE-ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ 1185
Query: 808 EKQKAYSEYTIQED---ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
+ + D EL ++ L + +EK+ E + E +L + + + N
Sbjct: 1186 HEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKAN 1245
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---K 921
L+ ++ + K + SE T +++L+ L R E ++++ Q
Sbjct: 1246 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305
Query: 922 KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
K+ E Q+E + K L + + L Q +E + L L
Sbjct: 1306 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ---RAL 1362
Query: 982 NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
+K N E+ K +T + TE+ KL L+ +E++ A+N K + + +
Sbjct: 1363 SKANSEVAQWRT-KYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQR 1421
Query: 1042 MVSDYESKLAQF---TTKLENMEEEMQRVSKQLLDSKQHNEE----LQILVREQDDQIKE 1094
+ + E + + ++++ + K L + K EE L+ ++E E
Sbjct: 1422 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE 1481
Query: 1095 LKETKLTFEMNIPKTEGMIISS-TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
L + K +E + + E + + +E D + Q E E
Sbjct: 1482 LFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADI 1541
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ-LNTENDN 1212
+ L+E A L E + ++L + +E+ E+I QLK ++ + T
Sbjct: 1542 QLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601
Query: 1213 LLSTVAELRSSISSAVDQRG-FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
L + V +I G E+ H ++ A+ K ++ QL + +
Sbjct: 1602 LDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA 1661
Query: 1272 LDSVQSSTQE----ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE- 1326
L + ++ E + +V L+ L+ E + +++ D ++++L ++
Sbjct: 1662 LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Query: 1327 --IEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ------MQEQSILNINEENAQLK 1378
+ K D R + K+ M + + + +A L+
Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVR 1438
+ R+++AE L+ + +++ E + E+ + Q+ + E+V+
Sbjct: 1782 RMKKNLEQTVKDLQHRLDEAEQLALK-GGKKQIQKLETRIRELEFELEGEQKKNT-ESVK 1839
Query: 1439 QQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITES 1498
L +YE+R+++LTY+ E + + L++ + + + K + + + E+ N +T+
Sbjct: 1840 G-LRKYERRVKELTYQSEEDRKNV-LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKF 1897
Query: 1499 VSLNKQVAELNKALEEEVAKTNEMQ 1523
++ E + + ++ N+++
Sbjct: 1898 RKAQHELEEAEERADIAESQVNKLR 1922
Score = 102 bits (245), Expect = 9e-21
Identities = 184/934 (19%), Positives = 404/934 (43%), Gaps = 78/934 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLE--AARFEISLE 270
++++ + E + E K + Q+ L D+++++ +++SL + LE E SLE
Sbjct: 981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 1040
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++SI +K +++E+ + +L K+E
Sbjct: 1041 QEKKLRVDLERNKRKLEGDLK----LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 1096
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q ++ KEL+ ++ + E +A + K + K + A +++ +L
Sbjct: 1097 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-----TEKQRSDYARELEELSERL 1151
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS--EKDTXXXXXXXXXXGKDT 447
T ++NK A+ + + L + + E +++ K +
Sbjct: 1152 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNL 1211
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKL 505
+ +LE ++ + + ++ E V++ E++ + L D++ + K ++ L
Sbjct: 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 1271
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQ--MQKTIDNFSKVSDSNKEIVRLT 561
Q ++L E ++ + + +S + + KQ Q+T + ++ + NK L
Sbjct: 1272 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331
Query: 562 EELHH-------LSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMIEMENLA 609
L L ++ E +E K LQ L +S E+D ++ E+E
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQ 1391
Query: 610 ETRLKAISLLESQKFDLVQELHIL----QQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
E + + E Q + + L Q+ EVED + D+ + S + K + +
Sbjct: 1392 EKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 1451
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
+ + +E +E + L + L+N E+ +++L+ +EN +L ++
Sbjct: 1452 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 1511
Query: 726 KMSAEKISELLAKINHEEQSKIQTQF---GIDAKIQERDLYIEN-------IESELSKYK 775
++ E+I+E I+ E+S+ Q + I ++E + +E+ I+ EL++ K
Sbjct: 1512 DLT-EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570
Query: 776 SRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLM 831
S I R + E +E + + +R + + S L + ++ +E + ++ +N + + +
Sbjct: 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630
Query: 832 DH--DRVVE--KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--R 885
H + E K L ++ + K+ Q L ++L+ L+ +++ N L + R
Sbjct: 1631 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELR 1690
Query: 886 TDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
L ++E + + L+SN + ++ H T ++ KK++E ++ +++E A RD +
Sbjct: 1691 ATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 1750
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
EK +K I + +L++ ++ +L E K NLE K +Q + ++
Sbjct: 1751 NAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQLA 1805
Query: 1005 -EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ +I KL +++ + E+ QK N V + YE ++ + T + E +
Sbjct: 1806 LKGGKKQIQKLETRIRELEFELEG-EQKKNTESVKGL---RKYERRVKELTYQSEEDRKN 1861
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ R+ + L+D +LQ+ V+ Q +E E
Sbjct: 1862 VLRL-QDLVD------KLQVKVKSYKRQAEEADE 1888
Score = 98.7 bits (235), Expect = 2e-19
Identities = 179/969 (18%), Positives = 399/969 (41%), Gaps = 54/969 (5%)
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+KS ++ T+ ++ K K+E+AK E + L + LV ++
Sbjct: 841 LKSAETEKEMATMKEEFQK--TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESEN 898
Query: 442 XXGKDTLIAQL-QLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQLKQELNDEIKDVNVK 499
+ QL + + Q + + + E++N E+ + +L+ E ++ KD++
Sbjct: 899 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 958
Query: 500 DL----IEKLKSA-EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
+L +EK K A E ++ L +E+ ++ + K+ K + Q+ +D+ D
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED-- 1016
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETRL 613
++ L + L Q+V +LE + VD + R +E D+ + +L +
Sbjct: 1017 -KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
Query: 614 KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA 673
+ L+ + F+ Q LQ K VED+ Q Q + + LEE+I+A A
Sbjct: 1076 QLDERLKKKDFEYCQ----LQSK---VEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
++ + + + E+L +++ + + E + L LE+ + +
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH-E 1187
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++A + + + + +I + +E E S++K I L S+ + +
Sbjct: 1188 AMVATLRKKHADSVAE---LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
+LE+ L L E + E EL + + L + +QL E E +L +
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 1304
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRIT 911
Q ++ + L+ L + + NAL +++R D + +Y+ + ++ ++ L+R
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD-CDLLREQYEEE-QEGKAELQRAL 1362
Query: 912 HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV----TQLEAQLQEY 967
+ + + Q + + E I+ ++E A + E+ +E V LE Q
Sbjct: 1363 SKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRL 1422
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +E+L ++VE N + L K+Q ++ + + A L+ +E +
Sbjct: 1423 QGEVEDLMVDVERANSLAAAL-----DKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 1477
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVRE 1087
L+ ++ + +Y + E+ + +N+E+E+ +++Q+ ++ + EL+ ++
Sbjct: 1478 LSTELFKLKNAYEEALDQLET----VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 1088 QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE 1147
+ + +++ E + E I+ +E ++ + +D LK +
Sbjct: 1534 IELEKADIQLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRKIAEKDEEIEQLKRNYQ 1592
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS---KLE 1204
+S L + N ++ L + +L+ + E + L+S +L+
Sbjct: 1593 RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 1652
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE--HELRVQLS 1262
D+ L +L+ + + V++R A L + + + A ++TE +L Q
Sbjct: 1653 DTQLHLDDALRGQEDLKEQL-AIVERR----ANLLQAEVEELRATLEQTERARKLAEQEL 1707
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
++ QLL + +S K+ T + LQ++++D RN +EK I +
Sbjct: 1708 LDSNERVQLLHTQNTSLIHTKKKLET--DLMQLQSEVEDASRDARNAEEKAKKAITDAAM 1765
Query: 1323 LRSEIEDEK 1331
+ E++ E+
Sbjct: 1766 MAEELKKEQ 1774
Score = 98.7 bits (235), Expect = 2e-19
Identities = 198/1034 (19%), Positives = 435/1034 (42%), Gaps = 105/1034 (10%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K + + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 904 ERCDQLIKAKFQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 350 ATMGTESKAVSSPSKKGSPLIS------RKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
A + E A + K + +S K R + ++ L +D +N
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 404 KNEIAKLEMVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLI----AQLQLEHQQ 458
K + +KLE ++ L L +K+ + + +++++ + QL+ +
Sbjct: 1023 KTK-SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERL 1081
Query: 459 HMEGPSLIHVGTNTEDVNEIA-KVQEQLK------QELNDEIK-DVNVKDLIEKLKS-AE 509
+ + + ED + + Q+++K +EL +EI+ + + EK +S
Sbjct: 1082 KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYA 1141
Query: 510 EQITQLNDEI-DAANKNMIKVKSNHK-----LKLKQ--MQKTIDNFSKVSDSNKE----I 557
++ +L++ + +A +++ N K LKL++ + T+ + + V+ K+ +
Sbjct: 1142 RELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSV 1201
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM-----ENLAETR 612
L E++ +L + +LE+EK +L + D S S + ++ + L+E R
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR 1261
Query: 613 LK------AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
K ++S L +QK L E L + ++E+K + +SQL + ++ L+
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSR---QLEEKESIVSQLSRSKQAFTQQTEELKR 1318
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
Q++ + +K LA +++ + D + L ++ + K ++ L E K E
Sbjct: 1319 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1378
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ ++ EL E Q K+ ++Q+ + +E + ++ + + RL+ +
Sbjct: 1379 DAIQRTEEL-----EEAQEKLA------QRLQDSEEQVEAVNAKCASLEKTKQRLQGEV- 1426
Query: 787 VMEDRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
ED +ER A+ L + L +KQ K +E+ + +E L + R + +L
Sbjct: 1427 --EDLMVDVER-ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 1483
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHY----NALVEKANRTDLAESESTKYQT 898
++++ +E + + + EN+NL+ ++D+ + + E E E Q
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV- 957
L + E+ L+ HE + I++ + E+ ++ E + +I + + L Y++ +E +
Sbjct: 1544 ALEEAEAALE---HE-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 958 TQLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ L+A+++ +N L +E +LN++ ++L H +Q ++ + ++
Sbjct: 1600 SALDAEVRS-RNEAIRLKKKMEGDLNEIEIQL--SHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
L ++ + + + + ++++ + LE E + ++LLDS
Sbjct: 1657 HL----DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS-- 1710
Query: 1077 HNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
NE +Q+L Q L TK E T+ M + S +E S DA N +
Sbjct: 1711 -NERVQLL----HTQNTSLIHTKKKLE-----TDLMQLQSEVEDASRDARNAEEKAKKAI 1760
Query: 1137 XXXXXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ 1195
+ + ++E Q+ S L+ L +++ ++ + E L L G ++Q
Sbjct: 1761 TDAAMMAEELKKE--QDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKG----GKKQ 1812
Query: 1196 INQLKSKLEQLNTE 1209
I +L++++ +L E
Sbjct: 1813 IQKLETRIRELEFE 1826
Score = 87.0 bits (206), Expect = 5e-16
Identities = 161/839 (19%), Positives = 341/839 (40%), Gaps = 88/839 (10%)
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
K E + + ++ E K K + + E +E++ +L ++ + L +Q + + +
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 816 YTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQH 875
+ D+L+ L + V ++ + E N EL K + L +E L+ + D++
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
A VEK E++ +L L+ + ++T E + L ++ ++DL+ E
Sbjct: 962 L-AKVEKEKHA--TENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE---- 1014
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQK 995
E + K E+ +E LE+ L++ K +L N +L +L+L + +
Sbjct: 1015 -EDKVNSLNKTKSKLEQQVE---DLESSLEQEKKLRVDLERNKRKLEG-DLKLAQESILD 1069
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ N+ +L+ LK+KD E L K+ + Q ++ ++ K+ +
Sbjct: 1070 LE-----------NDKQQLDERLKKKDFEYCQLQSKVEDEQ----TLGLQFQKKIKELQA 1114
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
++E +EEE++ +++ +K +++ D +EL+E E G + S
Sbjct: 1115 RIEELEEEIE--AERATRAKTE--------KQRSDYARELEELSERLE-----EAGGVTS 1159
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI 1175
+ IE L+ EE +Q +++ K + E +I
Sbjct: 1160 TQIE-----------LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQI 1208
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
L+ + +L + +I+ L S +E ++ NL L +S A + E
Sbjct: 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN--EE 1266
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSL 1295
+ L +++ Q EL QL ES QL S Q+ TQ Q L
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ----------QTEEL 1316
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
+ +L+++ + L + ++LR + E+E+ RT+
Sbjct: 1317 KRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG-KAELQRALSKANSEVAQWRTK 1375
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
++ + + + E+ AQ + S + + ++ Q E++D
Sbjct: 1376 YETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRL-----QGEVEDLM 1430
Query: 1416 I-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELA---ILRLKMHENAN 1471
+ ++ + L ++ F+ V L E++ + E+ E E+ L L ++ + N
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKV---LAEWKTKCEESQAELEASLKESRSLSTELFKLKN 1487
Query: 1472 HYETM--QKESEIERVKLIEELNVKITESVSLN-KQVAELNKALEE-EVAKTN------E 1521
YE Q E+ K +E+ +TE ++ N K + EL K+ ++ E+ K + E
Sbjct: 1488 AYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEE 1547
Query: 1522 MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
+ ALE++E +I+ + E+T +++ + ++ + + Q E + + ++ E+
Sbjct: 1548 AEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 1606
Score = 76.6 bits (180), Expect = 7e-13
Identities = 166/892 (18%), Positives = 356/892 (39%), Gaps = 65/892 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD LQ K++ +T L Q+KI E IE +
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E + + K+R + E +R LEEA EA
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLR-RDLEEATLQHEA 1188
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEE-KGSLEIAN 320
+ +H+ EL + KQ +E E K EI++ S+E +
Sbjct: 1189 MVATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEFKLEIDDLSSSMESVS 1240
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKSGRN 377
++ L K LE + R N+E++ L+ + T+ S+ + + L ++S +
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q + E Q ++ KN +A + + DL+ ++Y ++
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAH-ALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 438 XXXXXXGK-----------DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
D + +LE Q L E VN E+ K
Sbjct: 1360 RALSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
Q L E++D+ V D+ E+ L +D +N KV + K K ++ Q ++
Sbjct: 1420 QRLQGEVEDLMV-DV--------ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 547 FSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY-----DSGRMI-ESDVY 599
K S S + E+ +L ++ ++ E NL+ + D ++G+ I E +
Sbjct: 1471 SLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKS 1530
Query: 600 KKMIEMENLAETRL---KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC 656
+K IE+E A+ +L +A + LE ++ +++ L Q E++ K+A + D+
Sbjct: 1531 RKQIELEK-ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA-----EKDEEI 1584
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE 716
++K + SA E+ E ++L K+++ G + ++E + ++
Sbjct: 1585 EQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKKMEGDLNEIEIQLSHANRQAAETLKH 1643
Query: 717 NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESELSKY 774
+ +L+ L + + +EQ I + + A+++E +E E
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Query: 775 KSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHD 834
+ + E + ++ + SL +L + L + Q + + + +
Sbjct: 1704 EQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDA 1763
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
++ ++L + + + L++ + L + ++LQ L + +Q L K + + + E T
Sbjct: 1764 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ----LALKGGKKQIQKLE-T 1818
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
+ + +LE K+ T + L + ++ +++L + ++ +R + ++++ K
Sbjct: 1819 RIRELEFELEGEQKKNTESVKGL-RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK 1877
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYT 1004
Y Q E ++ ++ EL + ++ + V K + ++ D+T
Sbjct: 1878 SYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 1929
Score = 72.9 bits (171), Expect = 9e-12
Identities = 96/457 (21%), Positives = 208/457 (45%), Gaps = 43/457 (9%)
Query: 468 VGTNTEDVNEIAKVQEQLKQELND-----EIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
+ N + ++E+ K ++Q++ E D E + ++ K+ + ++TQ+ EID
Sbjct: 1517 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID-- 1574
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
K K + +LK + Q+T++ D+ VR E L +K +E + ++
Sbjct: 1575 RKIAEKDEEIEQLK-RNYQRTVETMQSALDAE---VRSRNEAIRLKKK---MEGDLNEIE 1627
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD---- 638
+ L + + + E+ + + ++ + L +T+L L Q+ DL ++L I++++ +
Sbjct: 1628 IQL-SHANRQAAETLKHLRSVQGQ-LKDTQLHLDDALRGQE-DLKEQLAIVERRANLLQA 1684
Query: 639 EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
EVE+ A + Q + + +E + + E++ L L + L+ D QL ++D
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 1744
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
D + K + I + + ++L+K + A + +++ QT + ++
Sbjct: 1745 ASRDARNAEEKAKKAITDAAMMAEELKKEQ-----DTSAHLERMKKNLEQTVKDLQHRLD 1799
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
E + + L K +I +LE I +E ++K + L++ ++ E T
Sbjct: 1800 EAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTY 1853
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
Q +E +R VL D +V+K ++++ ++ ++ +E N ++ QH
Sbjct: 1854 QSEE--DRKNVLRLQD-LVDKLQVKVKSYKRQAEEA-----DEQANAHLTKFRKAQH--E 1903
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
L E R D+AES+ K + + RD S+ + + HE +
Sbjct: 1904 LEEAEERADIAESQVNKLRAKTRDFTSS-RMVVHESE 1939
>AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin heavy
chain isoform SM1 protein.
Length = 1979
Score = 117 bits (282), Expect = 3e-25
Identities = 225/1168 (19%), Positives = 497/1168 (42%), Gaps = 102/1168 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEK---INEKDQIIEAKNKATTXXXXXX 200
VT ++ K++ L + + + E + +L++K + E+ +++ + +A T
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
++ ++ + +M+ +E E +D Q+L + + ++ LEE +
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEAR---LEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
EAAR ++ LE ++++ L+K E+ +EE+ S N
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTN 1021
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
+ E +K + L L + ELE +L E K S++ + RK AS
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDAS 1072
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ L ++ + ++ K E +L+ + L+ ++ K + +
Sbjct: 1073 DFHEQIADLQAQI--AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 441 XXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKK 1188
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
L E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENA 1241
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLK 614
L EL L Q E+E +K L+ + + S G +++ K+ +++N E+
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
++ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 670 ALSASKKELALVIENLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMD 719
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 1421 AYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMD 832
R E E + SL R ++ +E + KA E + +D++ + L
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEK 1597
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVL 946
+ Q QL + E+ L+ + KKK +++DLE++ ++ I E AI+ + L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 947 N---EKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +++ +E ++ A +E + ++L ++ +L + +L ++ ++ +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLE 1716
Query: 1000 SPDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ E+ + ++ NAL +K + I L +++ Q M +SD K Q +
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQ 1775
Query: 1057 LENMEEEMQRVSKQLLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTE 1110
L N E +R + Q +S ++ N+EL+ + E + +K + K T E I + E
Sbjct: 1776 LSN-ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ E A L+V++E + ++ +EQ+ K N +++
Sbjct: 1835 EQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQ 1888
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV--AELRSSISS-- 1226
++ + E + + + Q ++++ E + E + L S + S + S
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1948
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTE 1254
+ +R E A+ ++ R+ADF T+
Sbjct: 1949 SGGRRVIENADGSEEETDTRDADFNGTK 1976
Score = 113 bits (273), Expect = 4e-24
Identities = 180/980 (18%), Positives = 405/980 (41%), Gaps = 50/980 (5%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 984
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 1105 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 1157
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 1275
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 1336 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 1391
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVE 838
LE ++ ++ + L+ + +Q ++ Q+ EY + EDE R A+ + +E
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLE 1630
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + +
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEK 1687
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 1688 KAKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKE 1803
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 1804 LRSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 1078 NEELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 1858 LKEILLQVEDERKMAEQYKE 1877
Score = 109 bits (263), Expect = 6e-23
Identities = 192/966 (19%), Positives = 413/966 (42%), Gaps = 105/966 (10%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA 508
+AQ L+ ++ +E E V AK+++ L+ E+ + D L ++ K
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK-LEDEIL--VMDDQNNKLSKERKLL 1011
Query: 509 EEQITQLNDEI---DAANKNMIKVKSNHK-------LKLKQMQKTIDNFSKV-------- 550
EE+I+ L + + KN+ K+K+ H+ ++LK+ +K+ K+
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---- 606
SD +++I L ++ L ++A+ EEE LQ L D +++ KK+ E+E
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 607 NLAE---TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKS 661
+L E + A + E QK DL +EL L+ + ++ D A +L++ +Q + +K
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 662 VHLEE------QIDAL----SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
EE Q+ + + + +EL +E K K L + LE + D+ +L+
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
Q ++ K +K+ A+ + EL +K + E+++ + ++ K+ + +E++ L
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1303
Query: 772 SKYKSRICRLEESIAVM----EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
++ + + +L + +A + +D + L+ + Q + + ++ E +D+L +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ +R + +++ K+LQ + L E + Q + ++ Q Y EKA
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAA 1420
Query: 885 RTDLAESESTKYQTQL----------RDLESNLKRITHEHQTLIVQKKK-------EIED 927
D E + Q +L R L SNL++ + L+ ++K E +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 928 LEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKM 984
E E + A+ + L E E + +E + L+A++++ ++ +++ NV EL K
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 985 NLELIDKHVQKQQTQSPDYTEQY-INEINKLN------ALLKQKDEEIIALNQKINNAQV 1037
L + +++ +TQ + ++ E KL AL Q + ++ A +++ +
Sbjct: 1541 KRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI--LVREQDDQIKEL 1095
+ +YE++L E + + +K+ L+ + ELQ ++ +++ IK+L
Sbjct: 1600 QLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 1096 KETKLTF-----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ----- 1145
++ + E+ + I +T + A +++ +
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1146 -EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E+EE +E + L E + +I QLE E G+ +++ + + E
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
QL+ E ST A+ S ++++ E+ + ++ F+ T L +++
Sbjct: 1775 QLSNELATERST-AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E + EQ Q++T+ K ++++ + E + EK + Q++
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 1325 SEIEDE 1330
E E+E
Sbjct: 1894 EEAEEE 1899
Score = 103 bits (246), Expect = 7e-21
Identities = 177/876 (20%), Positives = 364/876 (41%), Gaps = 55/876 (6%)
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENI----ESELSKYKSR--ICRLEE 783
K EL + QSKI + G+ A ++E RDL I ++ ++ Y +R + ++
Sbjct: 759 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQ 818
Query: 784 SIAVME--DRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ M+ R + K + L K K + T QE+E+ + L + E+Q
Sbjct: 819 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ---KTKERQ 875
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E+E KEL++K+ L EE LQ L + Y E R LA ++ + + L
Sbjct: 876 Q-KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--RVRLA-AKKQELEEIL 931
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNTQIESAIRDKKVLNE-KYEKNIEYVT 958
++E+ L+ Q L ++KK + L++E + E A R K L + E I+ +
Sbjct: 932 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 959 QLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNA 1016
+ + N + +EE ++ + L ++ + K T+ + E I+E+
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-K 1075
++ +E+ L +K+ + ++D ++++A+ +L EEE+Q +L D
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111
Query: 1076 QHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
Q N L+ +RE + I +L+E N + + + +E + + +
Sbjct: 1112 QKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED----TL 1166
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVN 1192
L+ + E+E + L E++ ++QE K Q +E L +L +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL---EQFK 1223
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ + N K+K + L EN +L + L V+ + ++ E Q L + +D ++
Sbjct: 1224 RAKANLDKNK-QTLEKENADLAGELRVL-GQAKQEVEHKKKKL-EAQVQELQSKCSDGER 1280
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEHLRNLQE 1311
EL ++ +++ E SV E K + + + V SL ++LQD +E L+
Sbjct: 1281 ARAELNDKVHKLQNEVE----SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 1312 KYADV---INQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QM 1362
+ +V + Q+E R+ ++ DE++ D + + Q + +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
E+ +E L + N + ++ +L L+ ++ +
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLEK 1455
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
Q E +N+ + + R E EKE++ L + E E +++ +++
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 1483 ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
+ ++ E+L ++ + K V EL K+ + EM+T LE E E+ D
Sbjct: 1516 LKAEM-EDL---VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+ ++A + ++ + + + + QL +++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 89.8 bits (213), Expect = 7e-17
Identities = 178/834 (21%), Positives = 337/834 (40%), Gaps = 76/834 (9%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E EL K K R + E + +E + L + + L LQ + + Y+E +E+ RL
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE----AEEMRVRL 920
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + +E+ L E+E +E + + Q L E + + + D+++ E+A R
Sbjct: 921 AA---KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQK 975
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + E + +++ LE + + + + +++K +E+ + T + K L
Sbjct: 976 L-QLEKVTAEAKIKKLEDEI-LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL-NKMNLELIDKHVQ--KQQTQSPDYT 1004
+ K+ +++LE +L++ + + + L E+L K+ + D H Q Q Q +
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 1005 EQYINEINKLNALLKQKDEEIIALN---QKINNAQVSYMSMVSDYESKLA---QFTTKLE 1058
Q + +L A L + D+EI N +KI + + D +S+ A + +
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 1059 NMEEEMQRVSKQL---LDSKQHNEELQILVREQDDQI--KELKETKLTFEMNIPKTEGM- 1112
++ EE++ + +L LDS +EL+ REQ+ + K L E + E + +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELR-AKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 1113 -----IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++ +E N+D L E Q + ++ + KL +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+QE +K E EL +D V++ Q N+++S LN + ++ +S+SS
Sbjct: 1268 VQELQSKCSDGERARAEL--NDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDV-ASLSSQ 1323
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EL ++ Q+ +LR QL + + LD + Q I
Sbjct: 1324 LQ----DTQELLQEETRQK----LNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 1288 TME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
T+ Q++ + KLQD + L+E +IE L + E EK A
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLEKTKNRLQ 1433
Query: 1347 XXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
DL + + +Q+ E+ ++ A+ K S + E K L
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
L LE E + E T E E++ + K + +L K + L
Sbjct: 1494 SLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA----LE 1545
Query: 1464 LKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+M E E ++ E + E KL E+N++ + + +L E+ K ++
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFERDLQARDEQNEEKRRQL 1601
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFASDTK-QGRDEQL 1572
Q L E E L DE + + A+ K++ K + +D+ +GR+E +
Sbjct: 1602 QRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Score = 87.8 bits (208), Expect = 3e-16
Identities = 126/640 (19%), Positives = 264/640 (41%), Gaps = 36/640 (5%)
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +LQ+ K + ++EL + + +L + K++ ++Q Q+ E+ A K
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
Q+ EEI+ + + + K+AQ LE EE + ++Q L ++
Sbjct: 925 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTA 983
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +I E + + + + KL+ E + + +++ + + A N+
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
L+V+ ++E + R L++ KL + + + +I L+ EL +E++
Sbjct: 1044 SELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L+ + +N L + EL IS + +L + A+ +A+ QK +L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGE 1153
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYAD 1315
+L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 1154 ELEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 1365 -QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQE 1329
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESE 1481
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1482 I-ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDE 1539
V+ +EE + + + Q E A +++ KT N +Q L++ +++
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
++NL+ R + + + +S RD KE
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Score = 85.8 bits (203), Expect = 1e-15
Identities = 179/917 (19%), Positives = 371/917 (40%), Gaps = 91/917 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 1014 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 1371 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K K+ ++Q+ +D+ D+ +++V E+ ++ L EEK +
Sbjct: 1426 EKTKN-------RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL--LAEEKNISSKYAD 1476
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ D + K + + E L+A LE L E+ L D+V + +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 647 I--SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ S+ + E+K+ LEE D L A++ + N++ K Q ++ + E
Sbjct: 1537 LEKSKRALETQMEEMKT-QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 705 DIMNKLQNYIQE-NMDLTDK-----LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +LQ + E +L D+ L + +K+ L + + S I+ + +++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ +++ + EL ++ + + E + SLE QL L ++A + +
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 819 QEDELVNRLA-------VLMDHDRVVEKQLLEIEHENKELQ-----------KKNQILLE 860
+++EL LA L D R +E ++ ++E E +E Q K Q +
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 861 ENQNLQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITH 912
+ L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQE 966
+ + +K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 967 YKNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 1896 AEEESQRINANRRKLQR 1912
>AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY11)
(5'partial) protein.
Length = 1857
Score = 117 bits (282), Expect = 3e-25
Identities = 225/1168 (19%), Positives = 497/1168 (42%), Gaps = 102/1168 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEK---INEKDQIIEAKNKATTXXXXXX 200
VT ++ K++ L + + + E + +L++K + E+ +++ + +A T
Sbjct: 732 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 791
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
++ ++ + +M+ +E E +D Q+L + + ++ LEE +
Sbjct: 792 EEMRVRLAAKKQELEEILHEMEAR---LEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 847
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
EAAR ++ LE ++++ L+K E+ +EE+ S N
Sbjct: 848 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTN 899
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
+ E +K + L L + ELE +L E K S++ + RK AS
Sbjct: 900 LAEEEEKAKNLTKLKNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDAS 950
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ L ++ + ++ K E +L+ + L+ ++ K + +
Sbjct: 951 DFHEQIADLQAQI--AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISD 1007
Query: 441 XXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K
Sbjct: 1008 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKK 1066
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
L E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE
Sbjct: 1067 ALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENA 1119
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLK 614
L EL L Q E+E +K L+ + + S G +++ K+ +++N E+
Sbjct: 1120 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1179
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
++ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 1180 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1238
Query: 670 ALSASKKELALVIENLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMD 719
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 1239 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1298
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 1299 AYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1357
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMD 832
R E E + SL R ++ +E + KA E + +D++ + L
Sbjct: 1358 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1417
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 1418 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEK 1475
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVL 946
+ Q QL + E+ L+ + KKK +++DLE++ ++ I E AI+ + L
Sbjct: 1476 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1535
Query: 947 N---EKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +++ +E ++ A +E + ++L ++ +L + +L ++ ++ +
Sbjct: 1536 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLE 1594
Query: 1000 SPDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ E+ + ++ NAL +K + I L +++ Q M +SD K Q +
Sbjct: 1595 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQ 1653
Query: 1057 LENMEEEMQRVSKQLLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTE 1110
L N E +R + Q +S ++ N+EL+ + E + +K + K T E I + E
Sbjct: 1654 LSN-ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1712
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ E A L+V++E + ++ +EQ+ K N +++
Sbjct: 1713 EQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQ 1766
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV--AELRSSISS-- 1226
++ + E + + + Q ++++ E + E + L S + S + S
Sbjct: 1767 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1826
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTE 1254
+ +R E A+ ++ R+ADF T+
Sbjct: 1827 SGGRRVIENADGSEEETDTRDADFNGTK 1854
Score = 113 bits (273), Expect = 4e-24
Identities = 180/980 (18%), Positives = 405/980 (41%), Gaps = 50/980 (5%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 804 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 862
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 863 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 922
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 923 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 982
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 983 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 1035
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 1036 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1095
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 1096 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 1153
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 1154 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1213
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 1214 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 1269
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 1270 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1329
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 1330 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1389
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 1390 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1449
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVE 838
LE ++ ++ + L+ + +Q ++ Q+ EY + EDE R A+ + +E
Sbjct: 1450 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLE 1508
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + +
Sbjct: 1509 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEK 1565
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 1566 KAKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1623
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N
Sbjct: 1624 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKE 1681
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 1682 LRSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1735
Query: 1078 NEELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 1736 LKEILLQVEDERKMAEQYKE 1755
Score = 109 bits (263), Expect = 6e-23
Identities = 192/966 (19%), Positives = 413/966 (42%), Gaps = 105/966 (10%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA 508
+AQ L+ ++ +E E V AK+++ L+ E+ + D L ++ K
Sbjct: 833 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK-LEDEIL--VMDDQNNKLSKERKLL 889
Query: 509 EEQITQLNDEI---DAANKNMIKVKSNHK-------LKLKQMQKTIDNFSKV-------- 550
EE+I+ L + + KN+ K+K+ H+ ++LK+ +K+ K+
Sbjct: 890 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 949
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---- 606
SD +++I L ++ L ++A+ EEE LQ L D +++ KK+ E+E
Sbjct: 950 SDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRELEGHIS 1006
Query: 607 NLAE---TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKS 661
+L E + A + E QK DL +EL L+ + ++ D A +L++ +Q + +K
Sbjct: 1007 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1066
Query: 662 VHLEE------QIDAL----SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
EE Q+ + + + +EL +E K K L + LE + D+ +L+
Sbjct: 1067 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1126
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
Q ++ K +K+ A+ + EL +K + E+++ + ++ K+ + +E++ L
Sbjct: 1127 VLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1181
Query: 772 SKYKSRICRLEESIAVM----EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
++ + + +L + +A + +D + L+ + Q + + ++ E +D+L +
Sbjct: 1182 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1241
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ +R + +++ K+LQ + L E + Q + ++ Q Y EKA
Sbjct: 1242 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAA 1298
Query: 885 RTDLAESESTKYQTQL----------RDLESNLKRITHEHQTLIVQKKK-------EIED 927
D E + Q +L R L SNL++ + L+ ++K E +
Sbjct: 1299 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1358
Query: 928 LEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKM 984
E E + A+ + L E E + +E + L+A++++ ++ +++ NV EL K
Sbjct: 1359 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1418
Query: 985 NLELIDKHVQKQQTQSPDYTEQY-INEINKLN------ALLKQKDEEIIALNQKINNAQV 1037
L + +++ +TQ + ++ E KL AL Q + ++ A +++ +
Sbjct: 1419 KRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1477
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI--LVREQDDQIKEL 1095
+ +YE++L E + + +K+ L+ + ELQ ++ +++ IK+L
Sbjct: 1478 QLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1532
Query: 1096 KETKLTF-----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ----- 1145
++ + E+ + I +T + A +++ +
Sbjct: 1533 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1592
Query: 1146 -EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E+EE +E + L E + +I QLE E G+ +++ + + E
Sbjct: 1593 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1652
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
QL+ E ST A+ S ++++ E+ + ++ F+ T L +++
Sbjct: 1653 QLSNELATERST-AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1711
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E + EQ Q++T+ K ++++ + E + EK + Q++
Sbjct: 1712 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1771
Query: 1325 SEIEDE 1330
E E+E
Sbjct: 1772 EEAEEE 1777
Score = 103 bits (246), Expect = 7e-21
Identities = 177/876 (20%), Positives = 364/876 (41%), Gaps = 55/876 (6%)
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENI----ESELSKYKSR--ICRLEE 783
K EL + QSKI + G+ A ++E RDL I ++ ++ Y +R + ++
Sbjct: 637 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQ 696
Query: 784 SIAVME--DRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ M+ R + K + L K K + T QE+E+ + L + E+Q
Sbjct: 697 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ---KTKERQ 753
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E+E KEL++K+ L EE LQ L + Y E R LA ++ + + L
Sbjct: 754 Q-KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--RVRLA-AKKQELEEIL 809
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNTQIESAIRDKKVLNE-KYEKNIEYVT 958
++E+ L+ Q L ++KK + L++E + E A R K L + E I+ +
Sbjct: 810 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 869
Query: 959 QLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNA 1016
+ + N + +EE ++ + L ++ + K T+ + E I+E+
Sbjct: 870 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 929
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-K 1075
++ +E+ L +K+ + ++D ++++A+ +L EEE+Q +L D
Sbjct: 930 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 989
Query: 1076 QHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
Q N L+ +RE + I +L+E N + + + +E + + +
Sbjct: 990 QKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED----TL 1044
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVN 1192
L+ + E+E + L E++ ++QE K Q +E L +L +
Sbjct: 1045 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL---EQFK 1101
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ + N K+K + L EN +L + L V+ + ++ E Q L + +D ++
Sbjct: 1102 RAKANLDKNK-QTLEKENADLAGELRVL-GQAKQEVEHKKKKL-EAQVQELQSKCSDGER 1158
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEHLRNLQE 1311
EL ++ +++ E SV E K + + + V SL ++LQD +E L+
Sbjct: 1159 ARAELNDKVHKLQNEVE----SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1214
Query: 1312 KYADV---INQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QM 1362
+ +V + Q+E R+ ++ DE++ D + + Q + +
Sbjct: 1215 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1274
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
E+ +E L + N + ++ +L L+ ++ +
Sbjct: 1275 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLEK 1333
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
Q E +N+ + + R E EKE++ L + E E +++ +++
Sbjct: 1334 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1393
Query: 1483 ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
+ ++ E+L ++ + K V EL K+ + EM+T LE E E+ D
Sbjct: 1394 LKAEM-EDL---VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1449
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+ ++A + ++ + + + + QL +++
Sbjct: 1450 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1485
Score = 89.8 bits (213), Expect = 7e-17
Identities = 178/834 (21%), Positives = 337/834 (40%), Gaps = 76/834 (9%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E EL K K R + E + +E + L + + L LQ + + Y+E +E+ RL
Sbjct: 743 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE----AEEMRVRL 798
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + +E+ L E+E +E + + Q L E + + + D+++ E+A R
Sbjct: 799 AA---KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQK 853
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + E + +++ LE + + + + +++K +E+ + T + K L
Sbjct: 854 L-QLEKVTAEAKIKKLEDEI-LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 911
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL-NKMNLELIDKHVQ--KQQTQSPDYT 1004
+ K+ +++LE +L++ + + + L E+L K+ + D H Q Q Q +
Sbjct: 912 KLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQAQIAELK 967
Query: 1005 EQYINEINKLNALLKQKDEEIIALN---QKINNAQVSYMSMVSDYESKLA---QFTTKLE 1058
Q + +L A L + D+EI N +KI + + D +S+ A + +
Sbjct: 968 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1027
Query: 1059 NMEEEMQRVSKQL---LDSKQHNEELQILVREQDDQI--KELKETKLTFEMNIPKTEGM- 1112
++ EE++ + +L LDS +EL+ REQ+ + K L E + E + +
Sbjct: 1028 DLGEELEALKTELEDTLDSTATQQELR-AKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1086
Query: 1113 -----IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++ +E N+D L E Q + ++ + KL +
Sbjct: 1087 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAKQEVEHKKKKLEAQ 1145
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+QE +K E EL +D V++ Q N+++S LN + ++ +S+SS
Sbjct: 1146 VQELQSKCSDGERARAEL--NDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDV-ASLSSQ 1201
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EL ++ Q+ +LR QL + + LD + Q I
Sbjct: 1202 LQ----DTQELLQEETRQK----LNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHIS 1252
Query: 1288 TME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
T+ Q++ + KLQD + L+E +IE L + E EK A
Sbjct: 1253 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLEKTKNRLQ 1311
Query: 1347 XXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
DL + + +Q+ E+ ++ A+ K S + E K L
Sbjct: 1312 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1371
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
L LE E + E T E E++ + K + +L K + L
Sbjct: 1372 SLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA----LE 1423
Query: 1464 LKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+M E E ++ E + E KL E+N++ + + +L E+ K ++
Sbjct: 1424 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFERDLQARDEQNEEKRRQL 1479
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFASDTK-QGRDEQL 1572
Q L E E L DE + + A+ K++ K + +D+ +GR+E +
Sbjct: 1480 QRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1529
Score = 87.8 bits (208), Expect = 3e-16
Identities = 126/640 (19%), Positives = 264/640 (41%), Gaps = 36/640 (5%)
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +LQ+ K + ++EL + + +L + K++ ++Q Q+ E+ A K
Sbjct: 743 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 802
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
Q+ EEI+ + + + K+AQ LE EE + ++Q L ++
Sbjct: 803 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTA 861
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +I E + + + + KL+ E + + +++ + + A N+
Sbjct: 862 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 921
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
L+V+ ++E + R L++ KL + + + +I L+ EL +E++
Sbjct: 922 SELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 980
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L+ + +N L + EL IS + +L + A+ +A+ QK +L
Sbjct: 981 LARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGE 1031
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYAD 1315
+L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 1032 ELEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1088
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 1089 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1148
Query: 1365 -QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 1149 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQE 1207
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESE 1481
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 1208 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1267
Query: 1482 I-ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDE 1539
V+ +EE + + + Q E A +++ KT N +Q L++ +++
Sbjct: 1268 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1327
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
++NL+ R + + + +S RD KE
Sbjct: 1328 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1367
Score = 85.8 bits (203), Expect = 1e-15
Identities = 179/917 (19%), Positives = 371/917 (40%), Gaps = 91/917 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 892 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 948
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 949 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1008
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 1009 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1068
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 1069 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1128
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 1129 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1188
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 1189 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1248
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 1249 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1303
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K K+ ++Q+ +D+ D+ +++V E+ ++ L EEK +
Sbjct: 1304 EKTKN-------RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL--LAEEKNISSKYAD 1354
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ D + K + + E L+A LE L E+ L D+V + +
Sbjct: 1355 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1414
Query: 647 I--SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ S+ + E+K+ LEE D L A++ + N++ K Q ++ + E
Sbjct: 1415 LEKSKRALETQMEEMKT-QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1473
Query: 705 DIMNKLQNYIQE-NMDLTDK-----LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +LQ + E +L D+ L + +K+ L + + S I+ + +++
Sbjct: 1474 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1533
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ +++ + EL ++ + + E + SLE QL L ++A + +
Sbjct: 1534 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1593
Query: 819 QEDELVNRLA-------VLMDHDRVVEKQLLEIEHENKELQ-----------KKNQILLE 860
+++EL LA L D R +E ++ ++E E +E Q K Q +
Sbjct: 1594 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1653
Query: 861 ENQNLQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITH 912
+ L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++
Sbjct: 1654 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1713
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQE 966
+ + +K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E
Sbjct: 1714 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1773
Query: 967 YKNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 1774 AEEESQRINANRRKLQR 1790
>AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein.
Length = 1956
Score = 117 bits (282), Expect = 3e-25
Identities = 242/1159 (20%), Positives = 485/1159 (41%), Gaps = 134/1159 (11%)
Query: 480 KVQEQLKQ-ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
K++ +K E+ +E+ +K+ +L+ A E+ +E+ A ++ + K++ L+L+
Sbjct: 857 KIKPLVKSSEVGEEV--AGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQ 914
Query: 539 QMQKTIDNFSKVSD-SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
Q+T+ N + + K ++L + LS++V E EE L GR +E +
Sbjct: 915 AEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTAR------GRKLEDE 968
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
++ E+++L ET L ++S+K E H ++ +EVE DIS+L ++
Sbjct: 969 CFELKKEIDDL-ETML-----VKSEKEKRTTE-HKVKNLTEEVEFLNEDISKL--NRAAK 1019
Query: 658 EIKSVHLEEQIDALSASKKELALVIE-NLKLDKE--QLYGTIKDLENDK---EDIMNKLQ 711
++ H ++ +D L +++L+ + + NLKL+++ +L G ++ + E ++KL+
Sbjct: 1020 VVQEAH-QQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLE 1078
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQ--SKIQTQFGIDAKIQERDLYIENIES 769
++ N + + LE EL K Q SK++ + G+ A++Q+ ++ +++
Sbjct: 1079 GNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKT---VKELQT 1135
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE---KQKAYSEYTIQEDELVNR 826
++ K ++ + A ME R L + L L+E A E T +++ + +
Sbjct: 1136 QIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKIQK 1195
Query: 827 LAVLMDHDRV--------VEKQ----LLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
L M+ + ++K+ L E+E + + LQ+ Q L ++ +LQ+ + D+
Sbjct: 1196 LHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLT 1255
Query: 875 HYNALVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK---------- 923
+ KAN AE T Y+ +L + + L ++T L QK K
Sbjct: 1256 RVEQMTRAKAN----AEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLR 1311
Query: 924 ---EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
E E L + + + + R + L + EK + + L LQ+ + + + L EE
Sbjct: 1312 RLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEE 1371
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII-------------- 1026
++ EL + + K + + +Y N + + L+ +E+
Sbjct: 1372 EQEVKAEL-HRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVAN 1430
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVR 1086
A N + A+ + D S L + + ++++ + K L D KQ +EE Q L+
Sbjct: 1431 ARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLD 1490
Query: 1087 EQDDQIK----ELKETKLTFEMNIPKTEGMIISSTI--EPMSDDANNVDXXXXXXXXXXX 1140
+++ EL + K T+E +I E + + E +S+ N V
Sbjct: 1491 ASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEK 1550
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
K+ EEE+ + + L+E L E E QLE L + E +L
Sbjct: 1551 VKKLIEEEK-TEVQVTLEETEGAL--ERNESKILHFQLELLEAKA--------ELERKLS 1599
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
K E++ T+ L+SS+ S R E+ L K+ E D +E+ +Q
Sbjct: 1600 EKDEEIENFRRKQQCTIDSLQSSLDSEAKSR-IEVTRLKKK----MEEDL----NEMELQ 1650
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
LS Q+ ++ +S Q + Q+ LQ +L D + +L+E+ A +
Sbjct: 1651 LSCAN---RQVSEATKSLGQLQI-------QIKDLQMQLDDSTQLNSDLKEQVAVAERRN 1700
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
+L+SE+ED + N Y Q S+L+ + +L+
Sbjct: 1701 SLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQ--NTSLLS---QKKKLEAD 1755
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
+AE K + + E+ +K + TI +R E N+ Q
Sbjct: 1756 VARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKK--QDTIAHLERTRE--NMEQT 1811
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIE-RVKLIEELNVKITESV 1499
+ + +KR+ + ++A++ + + E E+E ++ E +
Sbjct: 1812 ITDLQKRLAEA-----EQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQ---RGAR 1863
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
L + + EL EE+ + MQT ++ ++++ ++ + SK +K
Sbjct: 1864 RLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQH 1923
Query: 1560 FASDTKQGRDEQLDNTMNK 1578
++ K+ R E ++ +NK
Sbjct: 1924 ELNEVKE-RAEVAESQVNK 1941
Score = 100 bits (240), Expect = 4e-20
Identities = 224/1060 (21%), Positives = 437/1060 (41%), Gaps = 107/1060 (10%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
V LS ++E++ S L + + +E +L+++I++ + ++ K
Sbjct: 941 VKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNL 1000
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
ED + + + EA Q+ L D+ ++ ++SSL +AN LE
Sbjct: 1001 TEEVEFLNEDISKLNRAAK---VVQEAH-----QQTLDDLHMEEEKLSSLSKANLKLEQQ 1052
Query: 264 RFEI--SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM 321
E+ +LE + A+ + + +++E S E K LE++ M
Sbjct: 1053 VDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQM 1112
Query: 322 TELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK---------------- 365
K+E + L Q+++T KEL+ ++ + + +A + K
Sbjct: 1113 NS---KVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLN 1169
Query: 366 -------GSPLISRKSGRNTASKMKSPWSQLSSETLNQDTD----KKINKNEIAKLE--- 411
GS L + + +K++ + TL+ +T KK + + +A+LE
Sbjct: 1170 ERLEEVGGSSLAQLEITKKQETKIQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQV 1229
Query: 412 ----MVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
V Q L KD D + + + T + L E + H L
Sbjct: 1230 ENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCT--LYEERLHEATAKLDK 1287
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD-LIEKLKSAEEQITQLNDEIDAANKNM 526
V T+ N++A + +L E + ++ + K+ LI +L + T+ +++ +
Sbjct: 1288 V---TQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKE 1344
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKV-AELEEEKGNLQLHL 585
K +S L++ Q+ D + + +E+ ELH KV AE+ + + + ++
Sbjct: 1345 TKSQSALAHALQKAQRDCDLLREQYEEEQEV---KAELHRTLSKVNAEMVQWRMKYENNV 1401
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKA---ISLLESQKFDLVQELHILQQKYDEVED 642
+ +E + I ++ AE A + LE + L EL +V
Sbjct: 1402 IQRTED--LEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRS 1459
Query: 643 KLA--DISQLQSDQVCSEIKSVHLEEQIDALSASKKEL-ALVIENLKLD---KEQLYGTI 696
A D QLQS + ++ K H E Q L AS+KE+ AL E LKL +E + G
Sbjct: 1460 AAARLDQKQLQSGKALADWKQKHEESQA-LLDASQKEVQALSTELLKLKNTYEESIVGQ- 1517
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ-TQFGIDA 755
+ L + +++ ++ N + + T L +M EK+ +L+ EE++++Q T +
Sbjct: 1518 ETLRRENKNLQEEISNLTNQVREGTKNLTEM--EKVKKLI----EEEKTEVQVTLEETEG 1571
Query: 756 KIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS 814
++ + I + + EL + K+ + R L E +E+ R + D L S L + K+
Sbjct: 1572 ALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRI 1631
Query: 815 EYTIQEDELVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E V RL M+ D +E QL + E K L + ++LQ+ L D
Sbjct: 1632 E--------VTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDST 1683
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
Q + L E + +AE ++ Q++L DL S L+ T + L ++ E + F
Sbjct: 1684 QLNSDLKE---QVAVAERRNSLLQSELEDLRS-LQEQTERGRRLSEEELLEATERINLFY 1739
Query: 934 TQIESAIRDKKVLN---EKYEKNIEYVTQ--LEAQLQEYKNNIENLNMNVEELNKMNLEL 988
TQ S + KK L + +K E V Q A+ + K IE N++ EEL K +
Sbjct: 1740 TQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLS-EELKKKQDTI 1798
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
H+++ + + EQ I ++ K L + + ++ ++I + + + E
Sbjct: 1799 --AHLERTR----ENMEQTITDLQK--RLAEAEQMALMGSRKQIQKLESRVRELEGELEG 1850
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
++ + + + + ++R K+L + +++ ++ Q D++ +LK ++ + +
Sbjct: 1851 EIRR-SAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKL-QLKVQNYKQQVEVAE 1908
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE 1148
T+ S + + N V LK++ E
Sbjct: 1909 TQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKARE 1948
Score = 99.1 bits (236), Expect = 1e-19
Identities = 250/1208 (20%), Positives = 496/1208 (41%), Gaps = 145/1208 (12%)
Query: 385 PWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXG 444
PW +L + ++ + E+A L+ L K L E+ +++
Sbjct: 850 PWMRLFFKIKPLVKSSEVGE-EVAGLKEECAQLQKALEKSEF---QREELKAKQVSLTQE 905
Query: 445 KDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLK-QELNDEIKDVNV--KDL 501
K+ LI QLQ E + +L +V E + + +K+Q + + +EL++ +++ +L
Sbjct: 906 KNDLILQLQAEQE------TLANVEEQCEWLIK-SKIQLEARVKELSERVEEEEEINSEL 958
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIV 558
+ + E++ +L EID ++K + + K+K + + ++ ++
Sbjct: 959 TARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAA 1018
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
++ +E H + +EEEK S + +++ E+E E KA
Sbjct: 1019 KVVQEAHQQTLDDLHMEEEK---------LSSLSKANLKLEQQVDELEGALEQERKARMN 1069
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQV-CSEIKS-VHLEEQIDA-LSAS 674
E + L L + ++ + +E ++ +L+ ++ S++ S V E+ + A L +
Sbjct: 1070 CERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKT 1129
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
KEL I++LK E T +E ++ D+ Q+ DL ++LE++ +++
Sbjct: 1130 VKELQTQIKDLKEKLEAERTTRAKMERERADL-------TQDLADLNERLEEVGGSSLAQ 1182
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L +I ++++KIQ + ++E L+ E + L K R +S+A
Sbjct: 1183 L--EITKKQETKIQK---LHRDMEEATLHFETTSASLKK------RHADSLA-------E 1224
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
LE + + L Q+ +K S+ ++ D+L+ R+ + EK E E K
Sbjct: 1225 LEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAK 1284
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
L + Q N L A +T L SES ++ +L + E+ + +++ E
Sbjct: 1285 --------------LDKVTQLANDLA--AQKTKL-WSESGEFLRRLEEKEALINQLSREK 1327
Query: 915 QTLIVQKKKEIEDL--EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
++IEDL ++E T+ +SA+ +K +++ + + + + QE K +
Sbjct: 1328 SNF----TRQIEDLRGQLEKETKSQSALAHAL---QKAQRDCDLLREQYEEEQEVKAELH 1380
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI---IALN 1029
L+K+N E++ + K + TE + +L L++ E + A N
Sbjct: 1381 ------RTLSKVNAEMVQWRM-KYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARN 1433
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
+ A+ + D S L + + ++++ + K L D KQ +EE Q L+
Sbjct: 1434 ASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQ 1493
Query: 1090 DQIK----ELKETKLTFEMNIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLK 1143
+++ EL + K T+E +I E + + E +S+ N V K
Sbjct: 1494 KEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKK 1553
Query: 1144 VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
+ EEE+ + + L+E L E E QLE L + E +L K
Sbjct: 1554 LIEEEK-TEVQVTLEETEGAL--ERNESKILHFQLELLEAK--------AELERKLSEKD 1602
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA 1263
E++ T+ L+SS+ S R E+ L K + E D +E+ +QLS
Sbjct: 1603 EEIENFRRKQQCTIDSLQSSLDSEAKSR-IEVTRLKK----KMEEDL----NEMELQLSC 1653
Query: 1264 FESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEIL 1323
Q+ ++ +S Q + Q+ LQ +L D + +L+E+ A + +L
Sbjct: 1654 AN---RQVSEATKSLGQLQI-------QIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLL 1703
Query: 1324 RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN----INEENAQLKK 1379
+SE+ED + TE + Q S+L+ + + A+++K
Sbjct: 1704 QSELEDLRSLQEQTERGRRLSEEELLE--ATERINLFYTQNTSLLSQKKKLEADVARMQK 1761
Query: 1380 SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI--YQKTH---EYTIT-LTQRNDE 1433
+ + A + L+ +L+ K I ++T E TIT L +R E
Sbjct: 1762 EAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAE 1821
Query: 1434 FENV-----RQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLI 1488
E + R+Q+ + E R+ +L E E E+ + A E KE + +
Sbjct: 1822 AEQMALMGSRKQIQKLESRVRELEGELEGEIR-RSAEAQRGARRLERCIKELTYQAEEDK 1880
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
+ L+ T+ L +V + +E + N+ + + Q+ E+ + + ++ V
Sbjct: 1881 KNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVN 1940
Query: 1549 ASSSKIQK 1556
K ++
Sbjct: 1941 KLKIKARE 1948
Score = 89.4 bits (212), Expect = 9e-17
Identities = 206/1051 (19%), Positives = 443/1051 (42%), Gaps = 102/1051 (9%)
Query: 568 SQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK--MIEMENLAETRL-KAISLLESQKF 624
S+K AE E G+L++ Y G I +K + ++E + + RL K +L +++
Sbjct: 760 SRKAAE--ELLGSLEIDHTQYRFG--ITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQ 815
Query: 625 DLVQELHILQQKYDEVEDKLADIS-QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
+ + QK E D L I +++ + L +I L S E+ +
Sbjct: 816 GKLMRIKF--QKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSS-EVGEEVA 872
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
LK + QL ++ E +E++ K + QE DL +L+ AE+ E LA + +
Sbjct: 873 GLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQ---AEQ--ETLANVEEQC 927
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
+ I+++ ++A+++E +E E S+ +R +LE D + L+++ D L
Sbjct: 928 EWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLE-------DECFELKKEIDDLE 980
Query: 804 SYL--QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
+ L EK+K +E+ ++ L + + + + ++ K +Q+ +Q L++
Sbjct: 981 TMLVKSEKEKRTTEHKVKN---------LTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1031
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY----QTQLRDLESNLKRITHEHQTL 917
+ LS + + L ++ + + A + K + +L LE NLK + L
Sbjct: 1032 LHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENL 1091
Query: 918 IVQKKKEIEDL---EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
++ E+L E+E + Q+ S + ++K L + +K ++ +L+ Q+++ K +E
Sbjct: 1092 ESSQRHLAEELRKKELELS-QMNSKVENEKGLVAQLQKTVK---ELQTQIKDLKEKLE-- 1145
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
E + +E + + + E+ + K+++ +I L++ +
Sbjct: 1146 ---AERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKIQKLHRDMEE 1202
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
A + + + + + + A +LE E +Q+V ++L K +LQ+ V + ++++
Sbjct: 1203 ATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKS---DLQLEVDDLLTRVEQ 1259
Query: 1095 LKETKLTFEMNIPKTEGMIISST--IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
+ K E E + +T ++ ++ AN++ E EF++
Sbjct: 1260 MTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWS--------ESGEFLR 1311
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL---TGHDVVNQEQINQLKSKLEQLNTE 1209
L+E+ A +N +E Q+E L +L T + + + + L +
Sbjct: 1312 R---LEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQ 1368
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ AEL ++S V+ + ++ ++ QR D + + EL ++L E+
Sbjct: 1369 YEEEQEVKAELHRTLSK-VNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQ--EAAEA 1425
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
+ + ++++ E + +E +L + + + R L +K + + + E+
Sbjct: 1426 MGVANARNASLERARHQLQLELGDALSDLGKVRSAAAR-LDQKQLQSGKALADWKQKHEE 1484
Query: 1330 EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN---INEENAQLKKSSXXXXX 1386
+ L TE K E+SI+ + EN L++
Sbjct: 1485 SQALLDASQKEVQA--------LSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTN 1536
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRND-EFENVRQQLVEYE 1445
+ + E KV +L +E + +E+ Q T E T +RN+ + + + +L+E +
Sbjct: 1537 QVREGTKNLTEME-KVKKL---IEEEKTEV-QVTLEETEGALERNESKILHFQLELLEAK 1591
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYETM---QKESEIE----RVKLIEELNVKITES 1498
+E EK+ E+ R K + ++ + +S IE + K+ E+LN +
Sbjct: 1592 AELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQL 1651
Query: 1499 VSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
N+QV+E K+L + + ++Q L++ L +++ + S+++
Sbjct: 1652 SCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLR 1711
Query: 1559 SFASDTKQGRDEQLDNTMNKELLDAVPRAEL 1589
S T++GR +ELL+A R L
Sbjct: 1712 SLQEQTERGR-----RLSEEELLEATERINL 1737
>AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein.
Length = 1984
Score = 117 bits (282), Expect = 3e-25
Identities = 225/1168 (19%), Positives = 497/1168 (42%), Gaps = 102/1168 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEK---INEKDQIIEAKNKATTXXXXXX 200
VT ++ K++ L + + + E + +L++K + E+ +++ + +A T
Sbjct: 859 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 918
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
++ ++ + +M+ +E E +D Q+L + + ++ LEE +
Sbjct: 919 EEMRVRLAAKKQELEEILHEMEAR---LEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 974
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
EAAR ++ LE ++++ L+K E+ +EE+ S N
Sbjct: 975 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTN 1026
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
+ E +K + L L + ELE +L E K S++ + RK AS
Sbjct: 1027 LAEEEEKAKNLTKLKNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDAS 1077
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ L ++ + ++ K E +L+ + L+ ++ K + +
Sbjct: 1078 DFHEQIADLQAQI--AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISD 1134
Query: 441 XXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K
Sbjct: 1135 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKK 1193
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
L E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE
Sbjct: 1194 ALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENA 1246
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLK 614
L EL L Q E+E +K L+ + + S G +++ K+ +++N E+
Sbjct: 1247 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1306
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
++ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 1307 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1365
Query: 670 ALSASKKELALVIENLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMD 719
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 1366 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1425
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 1426 AYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1484
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMD 832
R E E + SL R ++ +E + KA E + +D++ + L
Sbjct: 1485 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1544
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 1545 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEK 1602
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVL 946
+ Q QL + E+ L+ + KKK +++DLE++ ++ I E AI+ + L
Sbjct: 1603 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1662
Query: 947 N---EKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +++ +E ++ A +E + ++L ++ +L + +L ++ ++ +
Sbjct: 1663 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLE 1721
Query: 1000 SPDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ E+ + ++ NAL +K + I L +++ Q M +SD K Q +
Sbjct: 1722 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQ 1780
Query: 1057 LENMEEEMQRVSKQLLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTE 1110
L N E +R + Q +S ++ N+EL+ + E + +K + K T E I + E
Sbjct: 1781 LSN-ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1839
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ E A L+V++E + ++ +EQ+ K N +++
Sbjct: 1840 EQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQ 1893
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV--AELRSSISS-- 1226
++ + E + + + Q ++++ E + E + L S + S + S
Sbjct: 1894 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1953
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTE 1254
+ +R E A+ ++ R+ADF T+
Sbjct: 1954 SGGRRVIENADGSEEETDTRDADFNGTK 1981
Score = 113 bits (273), Expect = 4e-24
Identities = 180/980 (18%), Positives = 405/980 (41%), Gaps = 50/980 (5%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 931 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 989
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 990 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1049
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 1050 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1109
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 1110 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 1162
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 1163 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1222
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 1223 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 1280
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 1281 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1340
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 1341 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 1396
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 1397 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1456
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 1457 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1516
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 1517 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1576
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVE 838
LE ++ ++ + L+ + +Q ++ Q+ EY + EDE R A+ + +E
Sbjct: 1577 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLE 1635
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + +
Sbjct: 1636 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEK 1692
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 1693 KAKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1750
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N
Sbjct: 1751 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKE 1808
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 1809 LRSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1862
Query: 1078 NEELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 1863 LKEILLQVEDERKMAEQYKE 1882
Score = 109 bits (263), Expect = 6e-23
Identities = 192/966 (19%), Positives = 413/966 (42%), Gaps = 105/966 (10%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA 508
+AQ L+ ++ +E E V AK+++ L+ E+ + D L ++ K
Sbjct: 960 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK-LEDEIL--VMDDQNNKLSKERKLL 1016
Query: 509 EEQITQLNDEI---DAANKNMIKVKSNHK-------LKLKQMQKTIDNFSKV-------- 550
EE+I+ L + + KN+ K+K+ H+ ++LK+ +K+ K+
Sbjct: 1017 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1076
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---- 606
SD +++I L ++ L ++A+ EEE LQ L D +++ KK+ E+E
Sbjct: 1077 SDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRELEGHIS 1133
Query: 607 NLAE---TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKS 661
+L E + A + E QK DL +EL L+ + ++ D A +L++ +Q + +K
Sbjct: 1134 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1193
Query: 662 VHLEE------QIDAL----SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
EE Q+ + + + +EL +E K K L + LE + D+ +L+
Sbjct: 1194 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1253
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
Q ++ K +K+ A+ + EL +K + E+++ + ++ K+ + +E++ L
Sbjct: 1254 VLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1308
Query: 772 SKYKSRICRLEESIAVM----EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
++ + + +L + +A + +D + L+ + Q + + ++ E +D+L +
Sbjct: 1309 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1368
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ +R + +++ K+LQ + L E + Q + ++ Q Y EKA
Sbjct: 1369 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAA 1425
Query: 885 RTDLAESESTKYQTQL----------RDLESNLKRITHEHQTLIVQKKK-------EIED 927
D E + Q +L R L SNL++ + L+ ++K E +
Sbjct: 1426 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1485
Query: 928 LEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKM 984
E E + A+ + L E E + +E + L+A++++ ++ +++ NV EL K
Sbjct: 1486 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1545
Query: 985 NLELIDKHVQKQQTQSPDYTEQY-INEINKLN------ALLKQKDEEIIALNQKINNAQV 1037
L + +++ +TQ + ++ E KL AL Q + ++ A +++ +
Sbjct: 1546 KRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1604
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI--LVREQDDQIKEL 1095
+ +YE++L E + + +K+ L+ + ELQ ++ +++ IK+L
Sbjct: 1605 QLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1659
Query: 1096 KETKLTF-----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ----- 1145
++ + E+ + I +T + A +++ +
Sbjct: 1660 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1719
Query: 1146 -EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E+EE +E + L E + +I QLE E G+ +++ + + E
Sbjct: 1720 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1779
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
QL+ E ST A+ S ++++ E+ + ++ F+ T L +++
Sbjct: 1780 QLSNELATERST-AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1838
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E + EQ Q++T+ K ++++ + E + EK + Q++
Sbjct: 1839 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1898
Query: 1325 SEIEDE 1330
E E+E
Sbjct: 1899 EEAEEE 1904
Score = 103 bits (246), Expect = 7e-21
Identities = 177/876 (20%), Positives = 364/876 (41%), Gaps = 55/876 (6%)
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENI----ESELSKYKSR--ICRLEE 783
K EL + QSKI + G+ A ++E RDL I ++ ++ Y +R + ++
Sbjct: 764 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQ 823
Query: 784 SIAVME--DRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ M+ R + K + L K K + T QE+E+ + L + E+Q
Sbjct: 824 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ---KTKERQ 880
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E+E KEL++K+ L EE LQ L + Y E R LA ++ + + L
Sbjct: 881 Q-KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--RVRLA-AKKQELEEIL 936
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNTQIESAIRDKKVLNE-KYEKNIEYVT 958
++E+ L+ Q L ++KK + L++E + E A R K L + E I+ +
Sbjct: 937 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 996
Query: 959 QLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNA 1016
+ + N + +EE ++ + L ++ + K T+ + E I+E+
Sbjct: 997 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1056
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-K 1075
++ +E+ L +K+ + ++D ++++A+ +L EEE+Q +L D
Sbjct: 1057 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1116
Query: 1076 QHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
Q N L+ +RE + I +L+E N + + + +E + + +
Sbjct: 1117 QKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED----TL 1171
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVN 1192
L+ + E+E + L E++ ++QE K Q +E L +L +
Sbjct: 1172 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL---EQFK 1228
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ + N K+K + L EN +L + L V+ + ++ E Q L + +D ++
Sbjct: 1229 RAKANLDKNK-QTLEKENADLAGELRVL-GQAKQEVEHKKKKL-EAQVQELQSKCSDGER 1285
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEHLRNLQE 1311
EL ++ +++ E SV E K + + + V SL ++LQD +E L+
Sbjct: 1286 ARAELNDKVHKLQNEVE----SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1341
Query: 1312 KYADV---INQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QM 1362
+ +V + Q+E R+ ++ DE++ D + + Q + +
Sbjct: 1342 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1401
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
E+ +E L + N + ++ +L L+ ++ +
Sbjct: 1402 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLEK 1460
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
Q E +N+ + + R E EKE++ L + E E +++ +++
Sbjct: 1461 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1520
Query: 1483 ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
+ ++ E+L ++ + K V EL K+ + EM+T LE E E+ D
Sbjct: 1521 LKAEM-EDL---VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1576
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+ ++A + ++ + + + + QL +++
Sbjct: 1577 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1612
Score = 89.8 bits (213), Expect = 7e-17
Identities = 178/834 (21%), Positives = 337/834 (40%), Gaps = 76/834 (9%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E EL K K R + E + +E + L + + L LQ + + Y+E +E+ RL
Sbjct: 870 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE----AEEMRVRL 925
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + +E+ L E+E +E + + Q L E + + + D+++ E+A R
Sbjct: 926 AA---KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQK 980
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + E + +++ LE + + + + +++K +E+ + T + K L
Sbjct: 981 L-QLEKVTAEAKIKKLEDEI-LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1038
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL-NKMNLELIDKHVQ--KQQTQSPDYT 1004
+ K+ +++LE +L++ + + + L E+L K+ + D H Q Q Q +
Sbjct: 1039 KLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQAQIAELK 1094
Query: 1005 EQYINEINKLNALLKQKDEEIIALN---QKINNAQVSYMSMVSDYESKLA---QFTTKLE 1058
Q + +L A L + D+EI N +KI + + D +S+ A + +
Sbjct: 1095 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1154
Query: 1059 NMEEEMQRVSKQL---LDSKQHNEELQILVREQDDQI--KELKETKLTFEMNIPKTEGM- 1112
++ EE++ + +L LDS +EL+ REQ+ + K L E + E + +
Sbjct: 1155 DLGEELEALKTELEDTLDSTATQQELR-AKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1213
Query: 1113 -----IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++ +E N+D L E Q + ++ + KL +
Sbjct: 1214 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAKQEVEHKKKKLEAQ 1272
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+QE +K E EL +D V++ Q N+++S LN + ++ +S+SS
Sbjct: 1273 VQELQSKCSDGERARAEL--NDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDV-ASLSSQ 1328
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EL ++ Q+ +LR QL + + LD + Q I
Sbjct: 1329 LQ----DTQELLQEETRQK----LNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHIS 1379
Query: 1288 TME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
T+ Q++ + KLQD + L+E +IE L + E EK A
Sbjct: 1380 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLEKTKNRLQ 1438
Query: 1347 XXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
DL + + +Q+ E+ ++ A+ K S + E K L
Sbjct: 1439 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1498
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
L LE E + E T E E++ + K + +L K + L
Sbjct: 1499 SLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA----LE 1550
Query: 1464 LKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+M E E ++ E + E KL E+N++ + + +L E+ K ++
Sbjct: 1551 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFERDLQARDEQNEEKRRQL 1606
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFASDTK-QGRDEQL 1572
Q L E E L DE + + A+ K++ K + +D+ +GR+E +
Sbjct: 1607 QRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1656
Score = 87.8 bits (208), Expect = 3e-16
Identities = 126/640 (19%), Positives = 264/640 (41%), Gaps = 36/640 (5%)
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +LQ+ K + ++EL + + +L + K++ ++Q Q+ E+ A K
Sbjct: 870 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 929
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
Q+ EEI+ + + + K+AQ LE EE + ++Q L ++
Sbjct: 930 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTA 988
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +I E + + + + KL+ E + + +++ + + A N+
Sbjct: 989 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1048
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
L+V+ ++E + R L++ KL + + + +I L+ EL +E++
Sbjct: 1049 SELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1107
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L+ + +N L + EL IS + +L + A+ +A+ QK +L
Sbjct: 1108 LARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGE 1158
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYAD 1315
+L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 1159 ELEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1215
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 1216 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1275
Query: 1365 -QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 1276 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQE 1334
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESE 1481
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 1335 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1394
Query: 1482 I-ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDE 1539
V+ +EE + + + Q E A +++ KT N +Q L++ +++
Sbjct: 1395 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1454
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
++NL+ R + + + +S RD KE
Sbjct: 1455 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1494
Score = 85.8 bits (203), Expect = 1e-15
Identities = 179/917 (19%), Positives = 371/917 (40%), Gaps = 91/917 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 1019 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 1075
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 1076 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1135
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 1136 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1195
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 1196 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1255
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 1256 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1315
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 1316 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1375
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 1376 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1430
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K K+ ++Q+ +D+ D+ +++V E+ ++ L EEK +
Sbjct: 1431 EKTKN-------RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL--LAEEKNISSKYAD 1481
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ D + K + + E L+A LE L E+ L D+V + +
Sbjct: 1482 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1541
Query: 647 I--SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ S+ + E+K+ LEE D L A++ + N++ K Q ++ + E
Sbjct: 1542 LEKSKRALETQMEEMKT-QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1600
Query: 705 DIMNKLQNYIQE-NMDLTDK-----LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +LQ + E +L D+ L + +K+ L + + S I+ + +++
Sbjct: 1601 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1660
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ +++ + EL ++ + + E + SLE QL L ++A + +
Sbjct: 1661 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1720
Query: 819 QEDELVNRLA-------VLMDHDRVVEKQLLEIEHENKELQ-----------KKNQILLE 860
+++EL LA L D R +E ++ ++E E +E Q K Q +
Sbjct: 1721 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1780
Query: 861 ENQNLQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITH 912
+ L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++
Sbjct: 1781 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1840
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQE 966
+ + +K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E
Sbjct: 1841 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1900
Query: 967 YKNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 1901 AEEESQRINANRRKLQR 1917
>Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated
microtubule-binding protein protein.
Length = 1979
Score = 117 bits (281), Expect = 4e-25
Identities = 227/1060 (21%), Positives = 459/1060 (43%), Gaps = 116/1060 (10%)
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
+I+ +E++ LS +V+ LE E G+ + H+ + ++ ++ +++N+ +K
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWR-HIAQTSKAQGTDNSDQSEICKLQNI----IKE 220
Query: 616 ISLLESQKFDLVQ-ELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
+ SQ+ D Q E+ +LQ + + KL +IS+ +++ EE+I+ L
Sbjct: 221 LKQNRSQEIDDHQHEMSVLQNAHQQ---KLTEISRRHREELSD------YEERIEELENL 271
Query: 675 KKELALVIENLKLDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
++ + L K ++ TI+ L+ +K + K++ + D+ KL SAE
Sbjct: 272 LQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLS--SAENDR 329
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++L + +EQ ++ + +I E EN++ E SK L+ S D
Sbjct: 330 DILRR--EQEQLNVEKR-----QIMEE---CENLKLECSK-------LQPSAVKQSDTMT 372
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
ER Q S ++E + + E+E++ RL+ L + D + + L+++ + L+K
Sbjct: 373 EKERILAQSAS-VEEVFRLQQALSDAENEIM-RLSSL-NQDNSLAEDNLKLKMRIEVLEK 429
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ +L +E + LQ+SL + Y + A R +SE + L E L + E
Sbjct: 430 EKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE 489
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+TLI EIE+L+ + + I K L+++ + +++L+ L + K +
Sbjct: 490 KETLIA----EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L + ++ K + VQK++ +E +N+++ L+ K E ++ ++N
Sbjct: 546 LEDDKMDITK------ELDVQKEKLIQ---SEVALNDLHLTKQKLEDKVENLV---DQLN 593
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS--KQHNEELQ-ILVREQDD 1090
+Q S +S+ + + + + EEE+ R+ +L+ S + N + L++E++
Sbjct: 594 KSQESNVSI----QKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LK+ E + + +E D ++ E+
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT 709
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNT-ELTGHDVVNQEQINQLKSKLEQLNTE 1209
I E L+ + ++ EL C+ K LE N E T ++ N +N L E
Sbjct: 710 IVE--TLKMEKGEIEAEL--CWAKKRLLEEANKYEKTIEELSNARNLN-----TSALQLE 760
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH------ELRVQLSA 1263
+++L+ ++ EIAEL K+++ Q + D ++T+ E + QL+
Sbjct: 761 HEHLI-----------KLNQKKDMEIAEL-KKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 808
Query: 1264 FESKYEQLLDSVQ---SSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+K E ++ ++ S QEE +K + + L+ +++K+ L +++E+ + +
Sbjct: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRT--ENQSYKQMQEQSIL-NINEENAQ 1376
+E LR E L T E+ + Q I+ + N+ Q
Sbjct: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI--YQKTHEYTIT-LTQRNDE 1433
L +S + A +L LE KD EI QKT E T L + +
Sbjct: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLF--LE-KDEEIKSLQKTIEQIKTQLHEERQD 985
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
+ + + E +++ L E SE L E + + KE E+E +KL+ E N+
Sbjct: 986 IQTDNSDIFQ-ETKVQSLNIENGSEKH--DLSKAETERLVKGI-KERELE-IKLLNEKNI 1040
Query: 1494 KITESV-SLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASS 1551
+T+ + L+K +V +L + +++ K E+Q + I + ++ LQ ++A +
Sbjct: 1041 SLTKQIDQLSKDEVGKLTQIIQQ---KDLEIQAL--HARISSTSHTQDVVYLQQQLQAYA 1095
Query: 1552 SKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDL 1591
+ +K FA ++ R+ T +++D V E L
Sbjct: 1096 MEREK--VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL 1133
Score = 116 bits (279), Expect = 7e-25
Identities = 239/1121 (21%), Positives = 474/1121 (42%), Gaps = 118/1121 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ---EQLKQELNDEIKDVNVKDLI------- 502
++ H +H+ S GT+ D +EI K+Q ++LKQ + EI D + +
Sbjct: 187 EVGHWRHIAQTSKAQ-GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQ 245
Query: 503 ----------EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID--NFSKV 550
E+L EE+I +L + + +I+ + K+ +MQKTI KV
Sbjct: 246 KLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLS---KIYEMQKTIQVLQIEKV 302
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENLA 609
+S K++ +L +++ +++K++ E ++ L+ + R I + +E L
Sbjct: 303 -ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQ 361
Query: 610 ETRLKAISLLESQKFDL-----VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
+ +K + ++ L V+E+ LQQ + E+++ +S L D +E ++ L
Sbjct: 362 PSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAE-DNLKL 420
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+ +I+ L +KE +L L +KE+L ++ L N+ E I + I + +L D
Sbjct: 421 KMRIEVL---EKEKSL----LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEES 784
+ A K EL I+ E+++ I +D + QE ++ I+ +LSK ++ E
Sbjct: 474 LNLEA-KEQELNQSIS-EKETLIAEIEELDRQNQEATKHMILIKDQLSKQQN------EG 525
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+++ + L + ++ +K E +Q+++L+ L +D + KQ LE
Sbjct: 526 DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVAL--NDLHLTKQKLED 583
Query: 845 EHENKELQ-KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL 903
+ EN Q K+Q E N ++Q ++++H + N +L+ + Q+ +D
Sbjct: 584 KVENLVDQLNKSQ---ESNVSIQKENLELKEHI-----RQNEEELSRIRNELMQSLNQDS 635
Query: 904 ESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT-QLE 961
SN K + E + + K+ + +LE + N ++ D K+ NEK E V QLE
Sbjct: 636 NSNFKDTLLKEREAEVRNLKQNLSELE-QLNENLKKVAFDVKMENEKLVLACEDVRHQLE 694
Query: 962 A------QLQEYKNNI-ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
QL KN I E L M E+ + L K + ++ + E+ N N
Sbjct: 695 ECLAGNNQLSLEKNTIVETLKMEKGEI-EAELCWAKKRLLEEANKYEKTIEELSNARNLN 753
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
+ L+ + E +I LNQK D E +A+ +E M+ + + L S
Sbjct: 754 TSALQLEHEHLIKLNQK------------KDME--IAELKKNIEQMDTDHKETKDVLSSS 799
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ ++L L+ +++ I++LKE + + K + + I + D
Sbjct: 800 LEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLGS 857
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT--ELQECYTKIIQLET----LNTELTGH 1188
L QEE E ++E A T + E +++ QL T L E+ H
Sbjct: 858 MKEENNHL--QEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHH 915
Query: 1189 DVVNQEQIN---QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ ++Q QL L++ E D ++ ++ + ++ EI L K + Q
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKT-IEQ 974
Query: 1246 READFQKTEHELRVQLS-AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ + +++ S F+ Q L+ S + + +K T V ++++E
Sbjct: 975 IKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKG----IKEREL 1030
Query: 1305 HLRNLQEKYADVINQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ 1363
++ L EK + QI+ L + E+ T++ Y Q Q
Sbjct: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
Query: 1364 EQSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
Q+ E+ A L + + ++ AK L ++L+D T
Sbjct: 1091 LQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL---IKLQDENKKLSTRF 1147
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKM--HE----NANHYETM 1476
+ + +N+ + + E + I+ L+ + ++ LA+L+ +E N++ +E +
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQFEEL 1207
Query: 1477 QKESE--IERVKLIEELNVKITESV-SLNKQVAELNKALEE 1514
+E + ++VK +EE ++ +V ++ + A+L + L +
Sbjct: 1208 LQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248
Score = 112 bits (270), Expect = 9e-24
Identities = 301/1479 (20%), Positives = 582/1479 (39%), Gaps = 163/1479 (11%)
Query: 148 SNTIKEKDNALSVLQV--KMKIMETT------ILDLQEKINEKDQIIEAKNKATTXXXXX 199
S I + + +SVLQ + K+ E + + D +E+I E + +++
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLS 285
Query: 200 XXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEAN-- 257
+ K + TK E +E + KD ++L +D+ E+ N
Sbjct: 286 KIYEMQKTIQVLQIEKVESTKKMEQ---LEDKIKDINKKLSSAENDRDILRREQEQLNVE 342
Query: 258 --KLLEAARFEISLEHSKLAQE-LEQXXXXXXXXXXXXXXLAKQSI----EPSCEEKTEI 310
+++E + LE SKL ++Q + + + + + + EI
Sbjct: 343 KRQIMEECE-NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
Query: 311 EEKGSLEIANMT-----ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK 365
SL N +L +IE+LE + Q +EL+ L + E + + S
Sbjct: 402 MRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKS---- 457
Query: 366 GSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKE 425
TA++ S S+L LN LE Q LN+ + +KE
Sbjct: 458 ------------TATRDISLDSELHDLRLN--------------LEAKEQELNQSISEKE 491
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+I+E + K ++ + QL QQ+ EG S+I +D+N+ K QL
Sbjct: 492 TLIAEIEELDRQNQEAT--KHMILIKDQLSKQQN-EGDSII--SKLKQDLNDEKKRVHQL 546
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
+ + D K+++V+ EKL +E LND ++ K K K ++ +D
Sbjct: 547 EDDKMDITKELDVQK--EKLIQSE---VALND------LHLTKQKLEDK-----VENLVD 590
Query: 546 NFSKVSDSNKEIVRLTEEL-HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
+K +SN I + EL H+ Q EL + L L + ++ + ++ E
Sbjct: 591 QLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAE 650
Query: 605 MENLAETRLKAISLLESQK---FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
+ NL + + L E+ K FD+ E L ++V +L + L + S K+
Sbjct: 651 VRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEEC--LAGNNQLSLEKN 708
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT 721
+E + EL + L + + TI++L N + + LQ + + L
Sbjct: 709 TIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLN 768
Query: 722 DKLEKMSAE-KISELLAKINHEE-----QSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
K + AE K + +H+E S ++ Q + I +++++IE ++ SK +
Sbjct: 769 QKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQ 828
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-- 833
+ + +++ E R ++E K LGS +E E +E +R A + D
Sbjct: 829 EELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREE-QSRTAPVADPKT 887
Query: 834 -DRVVE-----KQLLEI-EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
D V E QL I EH +E++ +I+ ++NQ+ L +Q+ + E R
Sbjct: 888 LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE--FRY 945
Query: 887 DLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+ +T Q L + + +K + Q I Q K ++ + + T ++ KV
Sbjct: 946 QHEQMNATHTQLFL-EKDEEIKSL----QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQ 1000
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+ E E +A+ + I+ + ++ LN+ N+ L T+ D +
Sbjct: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISL---------TKQIDQLSK 1051
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+E+ KL +++QKD EI AL+ +I++ S+ V + +L + + E + +
Sbjct: 1052 --DEVGKLTQIIQQKDLEIQALHARISS--TSHTQDVVYLQQQLQAYAMEREKVFAVLNE 1107
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS---- 1122
+++ K ++ +V ++ + +L++ + + TI+ +S
Sbjct: 1108 KTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167
Query: 1123 DDANNVDXXXXXXXXXXXXLKV------------QEEEEFIQERSVLQEQSAKLNTELQE 1170
+ +D L+ + EE +QER L++Q K+ Q+
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQFEELLQERDKLKQQVKKMEEWKQQ 1227
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
T + ++ + +L QE+++QL++ Q+ ++DN + I S +Q
Sbjct: 1228 VMTTVQNMQHESAQL-------QEELHQLQA---QVLVDSDNNSKLQVDYTGLIQS-YEQ 1276
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME 1290
++ + Q LAQ + + + + L + QL + + Q +
Sbjct: 1277 NETKLKN-FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKS 1335
Query: 1291 QVTSLQNKL--QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXX 1348
+V S ++L Q+ EE ++LQEK A I ++ + D A
Sbjct: 1336 EVLSESSELLQQELEELRKSLQEKDA-TIRTLQENNHRLSDSIAATSELERKEHEQTDSE 1394
Query: 1349 XXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQ 1408
L+ + +++ ++ L I ++ QL SS + A + E
Sbjct: 1395 IKQLKEKQDVLQKLLKEKDLLIKAKSDQL-LSSNENFTNKVNENELLRQAVTNLKERILI 1453
Query: 1409 LELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
LE+ ++ K I T R E E Q L E + + EKE E M E
Sbjct: 1454 LEMDIGKL--KGENEKIVETYRGKETE--YQALQETNMKFSMMLREKEFECH----SMKE 1505
Query: 1469 NANHYETMQKESEI----ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQT 1524
A +E + KE E E +L+ + ++V ++ ++ AL+++ + +Q
Sbjct: 1506 KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
Query: 1525 ALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
++ + N E+ L+N + S + A D
Sbjct: 1566 EVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED 1604
Score = 102 bits (244), Expect = 1e-20
Identities = 224/1143 (19%), Positives = 465/1143 (40%), Gaps = 95/1143 (8%)
Query: 236 KQRLLKDIESK----DVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXX 291
K LLK+ E++ +S LE+ N+ L+ F++ +E+ KL E
Sbjct: 640 KDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 699
Query: 292 XXXLAKQS---IEPSCEEKTEIE------EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
L+ + +E EK EIE +K LE AN E T + EL N
Sbjct: 700 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE-ELSNARNLNTSALQ 758
Query: 343 KELENKLATMGTESKAVSSPSKKGSPL-ISRKSGRNTASKMKSPWSQLSSETLNQDTDKK 401
E E+ + + ++ K + K ++ S QL+ ++ +
Sbjct: 759 LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIE 818
Query: 402 INKNEIAKLEMVIQSLNKDLVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
K +KL+ + ++ L E + I EKD + +L+ E +
Sbjct: 819 KLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSR 878
Query: 459 H---MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDE---IKDVNVK--DLIEKLKSAEE 510
+ +L V +V+++ ++E L++E+ I+D N L++ L+ ++
Sbjct: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK 938
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
++ + + + N ++ ++K +QKTI+ ++ ++ K
Sbjct: 939 EMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETK 998
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
V L E G+ + L ++ R+++ + ++ +E++ L E + ++ D V +L
Sbjct: 999 VQSLNIENGSEKHDLSKAETERLVKG-IKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 1057
Query: 631 -HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
I+QQK E++ A IS Q V+L++Q+ A + ++++ V+ +
Sbjct: 1058 TQIIQQKDLEIQALHARISSTSHTQ-----DVVYLQQQLQAYAMEREKVFAVLNEKTREN 1112
Query: 690 EQL---YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
L Y + D+ KE + KLQ+ EN L+ + E + E + ++ + K
Sbjct: 1113 SHLKTEYHKMMDIVAAKEAALIKLQD---ENKKLSTRFESSGQDMFRETIQNLSRIIREK 1169
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
IDA Q+ + +++ + ++ + ++++R L+++ ++ +
Sbjct: 1170 ---DIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQFEELLQERD-KLKQQVKKMEEWK 1225
Query: 807 QE-----KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQL----LEIEHENKELQKKNQI 857
Q+ + + +QE+ + VL+D D + Q+ L +E E + KN
Sbjct: 1226 QQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKN-- 1283
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQT 916
+E +Q S+ + + L+ K + S ++ Q + L ++ + E
Sbjct: 1284 FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSE 1343
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN-IENLN 975
L+ Q E+E+L + ++ IR + N + +I ++LE + E ++ I+ L
Sbjct: 1344 LLQQ---ELEELRKSLQEK-DATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK----DEEIIALNQK 1031
+ L K+ L+ D ++ + Q E + N++N+ N LL+Q E I+ L
Sbjct: 1400 EKQDVLQKL-LKEKDLLIKAKSDQLLSSNENFTNKVNE-NELLRQAVTNLKERILILEMD 1457
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLE-NMEEEMQRVSKQLLDSKQHNEEL---QILVRE 1087
I + +V Y K ++ E NM+ M K+ + L Q+L +
Sbjct: 1458 IGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK 1517
Query: 1088 QDDQIKELKETKLTFEMNIPKT-------EGMIISSTIEPMSDDA--NNVDXXXXXXXXX 1138
+ + EL + + KT + ++++ + M + A N V
Sbjct: 1518 EQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRS 1577
Query: 1139 XXXLK------VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L+ ++ E+ + +E +++ AKL ++ +++ + +++ + +
Sbjct: 1578 NQELERLRNHLLESEDSYTREALAAEDREAKLRKKV-----TVLEEKLVSSSNAMENASH 1632
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQREADF 1250
Q + Q++S EQLN + T +L S V Q +A L +H Q E
Sbjct: 1633 QASV-QVESLQEQLNVVSKQRDETALQLSVS-QEQVKQYALSLANLQMVLEHFQQEEKAM 1690
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNL 1309
E E + QL A K + L+ S QE ++ ++ + L +L KEE + L
Sbjct: 1691 YSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEEL 1750
Query: 1310 QEK 1312
+ +
Sbjct: 1751 KRQ 1753
Score = 95.5 bits (227), Expect = 1e-18
Identities = 220/1094 (20%), Positives = 454/1094 (41%), Gaps = 94/1094 (8%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
++T + KM++ I E W K+RLL++ + I L A L +A ++ EH
Sbjct: 707 KNTIVETLKMEKGEIEAELCWA--KKRLLEEANKYEKTIEELSNARNLNTSA-LQLEHEH 763
Query: 272 S-KLAQELEQXXXXXXXXXXXXXXLAKQS---IEPSCEEK---TEIEEKGSLEIANMTEL 324
KL Q+ + K++ + S EE+ T++ K + I + E
Sbjct: 764 LIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKER 823
Query: 325 TKKI--ELLEHL-----NCQIRQTNKELENKLATMGTES-------KAVSSPSKKGSPLI 370
+ K+ EL ++ N +RQT +E + L +M E+ + + + +P+
Sbjct: 824 SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVA 883
Query: 371 SRKSGRNTASKMKSPWSQLSS--ETLNQDTD--KKINKNEIAKLEMVIQSLNKDLVDKEY 426
K+ ++ +++ S SQL++ E L ++ +KI +++ ++QSL + + +
Sbjct: 884 DPKT-LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
Query: 427 VISEKDTXXXXXXXXXXGKDTLIAQLQ-----LEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
+ + KD I LQ ++ Q H E + T+ D+ + KV
Sbjct: 943 FRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD---IQTDNSDIFQETKV 999
Query: 482 QEQLKQELNDEIKDVNVKD---LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
Q L E E D++ + L++ +K E +I LN++ + K + ++ + KL
Sbjct: 1000 QS-LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLT 1058
Query: 539 QM--QKTIDN---FSKVSDSN--KEIVRLTEELHHLS---QKVAELEEEKGNLQLHLVDY 588
Q+ QK ++ +++S ++ +++V L ++L + +KV + EK HL
Sbjct: 1059 QIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKT- 1117
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL-----HILQQKYDEVEDK 643
+ +M++ V K + L + K + ES D+ +E I+++K E+ D
Sbjct: 1118 EYHKMMDI-VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEI-DA 1175
Query: 644 LADISQ-----LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ Q LQ+ +E V+ Q + L + +L ++ ++ K+Q+ T+++
Sbjct: 1176 LSQKCQTLLAVLQTSSTGNEAGGVN-SHQFEELLQERDKLKQQVKKMEEWKQQVMTTVQN 1234
Query: 699 LENDKEDI---MNKLQNYIQENMDLTDKLEKMSA---EKISELLAKINHEEQSKIQTQFG 752
++++ + +++LQ + + D KL+ + + K+ + Q Q Q
Sbjct: 1235 MQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS 1294
Query: 753 IDAKIQERDLYIENIE--------SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
I +DL + ++ + L +S C V+ + L+++ ++L
Sbjct: 1295 IGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK 1354
Query: 805 YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
LQEK L + +A + +R +Q + KE Q Q LL+E
Sbjct: 1355 SLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDL 1414
Query: 865 LQISLSDMQQHYNA-LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI-VQKK 922
L + SD N K N +L T + ++ LE ++ ++ E++ ++ +
Sbjct: 1415 LIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRG 1474
Query: 923 KEIEDLEI-EFNTQIESAIRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
KE E + E N + +R+K+ + EK + + L+ + Q + L V+
Sbjct: 1475 KETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKS 1534
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYI--NEINKLNALLKQKDEEIIALNQKINNAQVS 1038
+ + + + Q E NE+ +L + ++E+ L + ++ S
Sbjct: 1535 MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDS 1594
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI-LVREQDDQI-KELK 1096
Y E + A+ K+ +EE++ S +++ H +Q+ ++EQ + + K+
Sbjct: 1595 YTREALAAEDREAKLRKKVTVLEEKLVS-SSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
ET L ++ + + +S M V +++++++ I E
Sbjct: 1654 ETALQLSVSQEQVKQYALSLANLQM------VLEHFQQEEKAMYSAELEKQKQLIAEWKK 1707
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E LQEC + + LT V +EQI +LK + E D++
Sbjct: 1708 NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Query: 1217 VAELRSSISSAVDQ 1230
+ L +S VD+
Sbjct: 1768 LMSLANSSEGKVDK 1781
>BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 117 bits (281), Expect = 4e-25
Identities = 195/954 (20%), Positives = 414/954 (43%), Gaps = 80/954 (8%)
Query: 234 DEKQRLLKD----IESKDVRISSLEEANKLLE-AARFEISLEHSKLAQELEQXXXXXXXX 288
+E++R ++D +E + + LE+ +++ E + LEH+++ +ELEQ
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARI-KELEQSLLFEKTK 490
Query: 289 XXXXXXLAKQSIEPSCEEKT---EIEEKGSLEIANMTELTKKIELLE-----HLNCQIRQ 340
+ + + EK+ E+E+ +L + + EL +++E + ++ + Q
Sbjct: 491 ADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ 550
Query: 341 TNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS--SETLNQDT 398
L+ KL T+ + + K+ ++ + + + +LS +E+L
Sbjct: 551 EISSLQEKLEVTRTDHQREITSLKEHFGA-REETHQKEIKALYTATEKLSKENESLKSKL 609
Query: 399 D--KKINKNEIA----KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQL 452
+ K N + IA KLE I S + + + + S+ T I ++
Sbjct: 610 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK---GLGTETAEFAELKTQIEKM 666
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ- 511
+L++Q +E E+ ++ +L + + + K+ +++ + KL AE+Q
Sbjct: 667 RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE--KENSLEAIRSKLDKAEDQH 724
Query: 512 ITQLNDEIDAANKNMIKVKSNHKLKLK--QMQKTIDNF-SKVSDSNKEIVRLT------- 561
+ ++ D ++ + IKVK L+ K + K IDNF S++ + ++++ L
Sbjct: 725 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 784
Query: 562 ---EELHHLSQKVAELEEEKGNLQLHL-VDYDSGRMIESDVYKKMIEMENLAETRLKAIS 617
E+ L Q++ E++ +L++ + I ++ + +++ NL E +S
Sbjct: 785 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN----LS 840
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
+ K L +EL IL++K+ E ++ + + + V K EEQ + LS+ ++
Sbjct: 841 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN---KLHQKEEQFNMLSSDLEK 897
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
L ENL D E + + E KL+N I E M ++ + EL
Sbjct: 898 LR---ENLA-DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNPSQLTKMNDELRL 953
Query: 738 KINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
K E+ +++ T+ +A ++ + +++E S+ ++ + EE +E + LE
Sbjct: 954 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLE 1012
Query: 797 RKADQLGSYLQEKQKAYSEYTIQ-----EDELVNRLAVLMD-HDRV--VEKQLLEIEHEN 848
+K + + QE + Y T + E+ L N L+D D++ ++ + E
Sbjct: 1013 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1072
Query: 849 KELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNL 907
+EL+K+ + + Q + ++ M+Q E + + + K Q +L L E+NL
Sbjct: 1073 EELRKQAE-KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1131
Query: 908 KRIT--HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
K + ++ + L+ + +++E+ E T ++A + + L+ E+N++ +L
Sbjct: 1132 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1191
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI 1025
E ++ + L LN LE+ K K + + I+ +ALL +KD E+
Sbjct: 1192 EVTSH-QKLEEERSVLNNQLLEM-KKRESKFIKDADEEKASLQKSISITSALLTEKDAEL 1249
Query: 1026 IALNQKI------NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
L ++ N + S S+V ES + K++N+E +++ +QL S + +
Sbjct: 1250 EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1309
Query: 1080 -ELQILVREQDDQIKELKETKLTFE---MNIPKTEGMIISSTIEPMSDDANNVD 1129
+ R Q+ QI L + + ++ M+ + + DD NN D
Sbjct: 1310 TQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1363
Score = 110 bits (264), Expect = 5e-23
Identities = 183/964 (18%), Positives = 401/964 (41%), Gaps = 83/964 (8%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L++K +E LA+ L+ +V V EQ AL+ + ++ K+D QL
Sbjct: 357 LKEKQQHIEQLLAE-RDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD--QL 413
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS-ELLAKINHEEQSKIQTQF 751
++ + +K +++N+L+ ++ DL ++E+ S K E ++I+ E+ QT+
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQIS-EDPENTQTKL 472
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
A+I+E +E L K++ +L+ + ED R + + S + E +K
Sbjct: 473 E-HARIKE-------LEQSLLFEKTKADKLQREL---EDTRVATVSEK----SRIMELEK 517
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
+ + EL RL V L + E LQ+K ++ ++Q ++
Sbjct: 518 DLALRVQEVAELRRRLESNKPAGDV--DMSLSLLQEISSLQEKLEVTRTDHQR---EITS 572
Query: 872 MQQHYNALVEKANRTDLAESEST-KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
+++H+ A E + A +T K + L+S L+ E+ +I K ++E
Sbjct: 573 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 632
Query: 931 EFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+E + K L + + E TQ+E +Y++ IENL + +
Sbjct: 633 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA--- 689
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALL-KQKDEEIIALNQKINNAQVSYMSM--VSDY 1046
K ++ + + ++ N + + + L K +D+ ++ + +N Q + + + +
Sbjct: 690 -KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 748
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLD-------SKQHNEELQILVREQDDQIKELKETK 1099
++K + T ++N +++ ++LLD S + E++ L ++ + K++K
Sbjct: 749 QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH-- 806
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQ 1158
L E N ++ I+ ++ N+ L ++E + ++E+ +
Sbjct: 807 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL--EKELQILKEKFAEAS 864
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
E++ + +QE K+ Q E L+ +E + +++K + + + L+
Sbjct: 865 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 924
Query: 1219 ELRSSISSAVDQRGFEIAELWKQH--LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
+L + I+ + G ++L K + L +E D + EL+++L+ L S++
Sbjct: 925 KLENDIAEIMKMSGDNPSQLTKMNDELRLKERDVE----ELQLKLTKANENASFLQKSIE 980
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
T V EQ S Q + EE + L+ K +D+ ++E ++ ++ K +
Sbjct: 981 DMT-------VKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1031
Query: 1337 XXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+L Q E + EEN+ L +
Sbjct: 1032 ATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQT 1087
Query: 1397 DAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE 1456
+A +++ Q+ + +E + T + +E + +++ + K +E+L KE
Sbjct: 1088 AEDA--MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL---KNVEELNKSKE 1142
Query: 1457 SELAILRLKMHENANHYETMQKES--EIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
L + KM E ET+++ + + +++ ++E NVK+ E + ++ ++ LEE
Sbjct: 1143 L-LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1201
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
E + N ++ +E + + DE + +QK +S S +D +L+
Sbjct: 1202 ERSVLNNQLLEMKKRESKFIKDADE----------EKASLQKSISITSALLTEKDAELEK 1251
Query: 1575 TMNK 1578
N+
Sbjct: 1252 LRNE 1255
Score = 97.5 bits (232), Expect = 3e-19
Identities = 197/1021 (19%), Positives = 433/1021 (42%), Gaps = 94/1021 (9%)
Query: 347 NKLATMGTESKAVSS-PSKKG-----SPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK 400
+ L++M + + +VSS PS+ G S +RK TA + Q E L + D
Sbjct: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERD- 372
Query: 401 KINKNEIAKLEMVIQSLNKDLV-----DKEYVI---SEKDTXXXXXXXXXXGKDTLIAQL 452
+ + E+AK + + ++L ++V+ ++ D K L+ QL
Sbjct: 373 -LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQL 431
Query: 453 QLEHQQHMEGPSLIHVGTNTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ 511
+ E ++ + + + T+ D+ + +++ E + +++ +K+L + L + +
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLEQKSQISED-PENTQTKLEHARIKELEQSLLFEKTK 490
Query: 512 ITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVS---DSNKEIVRLTEELHHLS 568
+L E++ + KS K + + +++ +SNK + L L
Sbjct: 491 ADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS-LL 549
Query: 569 QKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
Q+++ L+E+ L + D R I S K+ ET K I L + L +
Sbjct: 550 QEISSLQEK-----LEVTRTDHQREITS--LKEHFGARE--ETHQKEIKALYTATEKLSK 600
Query: 629 ELHILQQKYDEVEDKLADI-----SQLQ----SDQVCSEIKSVHLEEQIDALSASKKELA 679
E L+ K + + +D+ S+L+ S Q E V + + +A EL
Sbjct: 601 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK 660
Query: 680 LVIENLKLDKEQLYGTIKDLENDK--------EDIMNKLQNYIQENMD----LTDKLEKM 727
IE ++LD + +++ ++ + E + KL I+E + + KL+K
Sbjct: 661 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA 720
Query: 728 SAEKISELLAKIN--HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE--- 782
+ + E+ +N E + K++ + AK E+ I+N S+L + ++ L+
Sbjct: 721 EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 780
Query: 783 ----ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E + M+ R LE Q+ EK S+ + EL R L + ++
Sbjct: 781 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN----LQ 836
Query: 839 KQLLEIEHENKELQKKNQILLE---ENQNLQISLS-DMQQHYNALVEKANRTDLAESEST 894
+ L E+ + L+K+ QIL E E +S+ MQ+ N L +K + ++ S+
Sbjct: 837 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 896
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
K + L D+E+ + + LI K+K D+ ++ + K +N++
Sbjct: 897 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNPSQLTK-MNDELRLKE 955
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
V +L+ +L + N L ++E++ + E + K+ + E+ ++++ K
Sbjct: 956 RDVEELQLKLTKANENASFLQKSIEDMT-VKAEQSQQEAAKKHEEEKKELERKLSDLEKK 1014
Query: 1015 NALLKQKDEEIIALNQK-INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
+ +E+ A ++ + + + ++ + + L KL+ EE + ++L +
Sbjct: 1015 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1074
Query: 1074 SKQHNEELQILVREQDD-QIKE---LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
++ E+ + +D QI E ++T+ + K + + ++ + ++ N +
Sbjct: 1075 LRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN-NLKN 1133
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNTEL 1185
++ Q+ EEF +E L++ +A+ + + LQE K+ +L E+
Sbjct: 1134 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1193
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
T H + +E+ + L ++L ++ + E ++S+ ++ + L +
Sbjct: 1194 TSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSI--------SITSALLTE 1244
Query: 1246 READFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEH 1305
++A+ +K +E+ V L + + L VQ+ E++K+ +V +L+ +L++ +
Sbjct: 1245 KDAELEKLRNEVTV-LRGENASAKSLHSVVQTL---ESDKVKLELKVKNLELQLKENKRQ 1300
Query: 1306 L 1306
L
Sbjct: 1301 L 1301
Score = 61.7 bits (143), Expect = 2e-08
Identities = 116/623 (18%), Positives = 255/623 (40%), Gaps = 61/623 (9%)
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+Q+ + + EQ + E + A + + + + Q++ A+ + V + E+K+ Q
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
T +E + E + QL + K+ E+LQ V E+ +L++ K++
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQ----------KSQ-- 460
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEFIQERSVLQEQSAKLNTELQEC 1171
+S+D N +++E E+ + E++ ++ KL EL++
Sbjct: 461 --------ISEDPENTQTKLEHA-------RIKELEQSLLFEKT----KADKLQRELEDT 501
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND-----NLLSTVAELRSSISS 1226
+ ++ EL + +++ +L+ +LE D +LL ++ L+ +
Sbjct: 502 RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 561
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
EI L K+H RE QK L + E L ++ + +E ++ I
Sbjct: 562 TRTDHQREITSL-KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 620
Query: 1287 VTMEQ--VTSLQNKLQDKEE-------HLRNLQEKYADVINQIEILRSEIEDEKVAFXXX 1337
+ T++ + Q EE L ++A++ QIE +R + + E
Sbjct: 621 ALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ 680
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
LR + + +E S+ I ++L K+ ++ +
Sbjct: 681 QDSERAAHAKEMEALRAKLMKVIKEKENSLEAI---RSKLDKAEDQHLVEMEDTLNKLQE 737
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTITLTQRND---EFENVRQQLVEYEKRIEDLTYE 1454
AE KV EL L+ K +E + +T L + + + +R+ E + ++ L +
Sbjct: 738 AEIKVKEL-EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ 796
Query: 1455 KE-SELAILRLKMHENANHYETMQKESEIERVKL-IEELNVKITESVSLNKQVAELNKAL 1512
E +E I L++ +NA + E++ +L + L ++E + + + + + L
Sbjct: 797 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL 856
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
+E+ A+ +E +++ E V + NM+ + K++++++ + +DE+
Sbjct: 857 KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER- 915
Query: 1573 DNTMNKELLDAVPRAELDLAMYM 1595
++L+ A + E D+A M
Sbjct: 916 ----EEQLIKAKEKLENDIAEIM 934
Score = 59.3 bits (137), Expect = 1e-07
Identities = 133/690 (19%), Positives = 279/690 (40%), Gaps = 75/690 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMK--------IMETTILDLQE-------------KINEKDQI 185
L IKEK+N+L ++ K+ ME T+ LQE K NE+ ++
Sbjct: 699 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 758
Query: 186 IE---AKNKATTXXXXXXXXXXXXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQR- 238
I+ ++ KAT + K QQ+ ++ +E E E +
Sbjct: 759 IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 818
Query: 239 --LLKDIESKDVRISSLE----EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXX 292
+ ++++ +++++++L+ E +++ E E+ + K A+ E+
Sbjct: 819 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 878
Query: 293 XXLAKQ---------SIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK 343
L ++ +E E ++E K + +L K E LE+ +I + +
Sbjct: 879 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 938
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+ ++L M E + + + L K+ N + KS +Q K +
Sbjct: 939 DNPSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 997
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXXXXXXXGKDTLIAQLQ---LEHQQH 459
+ E +LE + L K + E K + ++ LQ L+ +
Sbjct: 998 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1057
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLK--QELND--EIKDVNVKDLIEKLKSAE---EQI 512
++G + G +++ E+ K E+ K Q D +I + K+ E L S E +
Sbjct: 1058 LKGAREENSGL-LQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1116
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
+L +E+D +N +K+ +L + T++N K+ + KEI L + SQ+++
Sbjct: 1117 AKLQNELDTLKEN--NLKNVEELNKSKELLTVEN-QKMEEFRKEIETLKQAAAQKSQQLS 1173
Query: 573 ELEEEKGNLQLHLVDYDSGR-MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
L+EE L L GR E ++K+ E ++ +L + ES+ E
Sbjct: 1174 ALQEENVKLAEEL-----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1228
Query: 632 ILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
QK + L + +++ +E+ + E +AS K L V++ L+ DK +
Sbjct: 1229 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------NASAKSLHSVVQTLESDKVK 1282
Query: 692 LYGTIKDLENDKEDIMNKLQN---YIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KI 747
L +K+LE ++ +L + D ++ ++ + ++ ++ + + Q K+
Sbjct: 1283 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1342
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSR 777
+ + +A + + N +S+ + +S+
Sbjct: 1343 KVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1372
Score = 52.0 bits (119), Expect = 2e-05
Identities = 124/648 (19%), Positives = 249/648 (38%), Gaps = 63/648 (9%)
Query: 4 TKNIDH-PSEMELSEETTARLPSSEVSSVAGXXXXXXXXXXXXXXXERQIKFERAQKCLE 62
TK ID+ S+++ +EE L + +S G E+QIK +K E
Sbjct: 756 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLEIEKNAE 814
Query: 63 NAALVSKRIKEHRKATAELLGRPF-VPGISESLANTLKQKEILMEKIKQYKELSKRSSTT 121
++ S T EL GR + + E+L+ + KE L ++++ KE +S
Sbjct: 815 SSKASS--------ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 866
Query: 122 IVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINE 181
V + N + +K+ ++L ++ + + D++ K E
Sbjct: 867 AVSVQRS---------------MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 911
Query: 182 KD----QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQ 237
KD Q+I+AK K D Q+TKM + E + ++ +
Sbjct: 912 KDEREEQLIKAKEKLENDIAEIMKMSG--------DNPSQLTKMNDELRLKERDVEELQL 963
Query: 238 RLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAK 297
+L K E+ S+E+ E ++ E + +H + +ELE+ +
Sbjct: 964 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD-----------LE 1012
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESK 357
+ +E S + E+ K E A TK E+L++L ++T + E+KL E+
Sbjct: 1013 KKMETSHNQCQEL--KARYERATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENS 1066
Query: 358 AVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ ++ + TA Q++ E + K AKL+ + +L
Sbjct: 1067 GLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1126
Query: 418 NK-DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN 476
+ +L + E + K+ + + Q Q+ + +L N +
Sbjct: 1127 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAE 1184
Query: 477 EIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
E+ + ++++ Q+L +E +N L+E K + I ++E + K++ +
Sbjct: 1185 ELGRSRDEVTSHQKLEEERSVLN-NQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1243
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K +++K + + + N L + L +LE + NL+L L ++ R +
Sbjct: 1244 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL--KENKRQL 1301
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
S + + + I L S DL ++ L+ K + + +
Sbjct: 1302 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1349
Score = 48.4 bits (110), Expect = 2e-04
Identities = 106/587 (18%), Positives = 240/587 (40%), Gaps = 44/587 (7%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+ HL + + S + +++ E + +LQE ++E Q+ E K
Sbjct: 804 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 863
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
++ + K+ + + ++L +++ + + +E + L A
Sbjct: 864 SEEAVSVQRSMQETVNKLHQKEEQFNM-LSSDLEKLRENLADMEAKFREKDEREEQLIKA 922
Query: 264 RFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+ ++ + +++ ++ L ++ +E + T+ E S ++ +
Sbjct: 923 KEKLENDIAEI-MKMSGDNPSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 981
Query: 324 LTKKIELLEHLNC-QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+T K E + + + KELE KL+ + E K +S N ++
Sbjct: 982 MTVKAEQSQQEAAKKHEEEKKELERKLSDL--EKKMETS--------------HNQCQEL 1025
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
K+ + + +SET + ++I +N + K + + K ++ + ++
Sbjct: 1026 KARYERATSET--KTKHEEILQN-LQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKA 1082
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
T +Q+ Q E + +T+ N AK+Q +L D +K+ N+K+ +
Sbjct: 1083 KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN--AKLQNEL-----DTLKENNLKN-V 1134
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
E+L ++E +T N +++ K + +K K +Q+ + K+++ E+ R +
Sbjct: 1135 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE---ELGRSRD 1191
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
E+ QK+ E N L + +S + ++D K ++ + L E +
Sbjct: 1192 EVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1250
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
K L E+ +L+ + + + + L+SD+V E+K +LE Q L +K++L+
Sbjct: 1251 K--LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQ---LKENKRQLSSSS 1305
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ-ENMDLTDKLEKMS 728
N ++ + + + D +N + +Q +N DL K+E MS
Sbjct: 1306 GNTDTQADE----DERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1348
>X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mRNA
for embryonic myosin heavy chain (SMHCE). ).
Length = 1085
Score = 116 bits (280), Expect = 5e-25
Identities = 202/1095 (18%), Positives = 462/1095 (42%), Gaps = 95/1095 (8%)
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMIEM 605
F K D E+ + + L +K+ L +EK +LQL V +S +++++ ++I+
Sbjct: 2 FQKTKD---ELAKSEAKRKELEEKLVTLVQEKNDLQLQ-VQAESENLLDAEERCDQLIKA 57
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYD--------EVEDKLADISQLQSDQVCS 657
+ E ++K ++ + ++ EL ++K + +++D +++++ ++ +
Sbjct: 58 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 117
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
E K +L E++ L + +L + L+ +Q ++ E DK + +NK ++ +++
Sbjct: 118 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ-AEEDKVNSLNKTKSKLEQQ 176
Query: 718 M-DLTDKLEKMSAEKIS------ELLAKINHEEQSKIQTQFG---IDAKIQERDLYIENI 767
+ DL LE+ ++ +L + ++S + + +D +++++D +
Sbjct: 177 VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQL 236
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+S++ ++ + ++ I ++ R LE + + + + +K S+Y + +EL RL
Sbjct: 237 QSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 296
Query: 828 -------AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
+ ++ ++ E + L++ + +E +++ ++ L+ +D +
Sbjct: 297 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV---ATLRKKHADSVAELGEQI 353
Query: 881 EKANRT-DLAESESTKYQTQLRDLESNLKRITHEH-------QTLIVQ------KKKEIE 926
+ R E E ++++ ++ DL S+++ ++ +TL Q K +EI+
Sbjct: 354 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 413
Query: 927 DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
E TQ + L+ + E+ V+QL Q + E L +EE NK
Sbjct: 414 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 473
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEIN---KLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
L +Q + EQY E +L L + + E+ K + +
Sbjct: 474 ALAHA-LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 532
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQ----HNEELQILVREQDDQIKELK 1096
+ + KLAQ +L++ EE+++ V+ + L +KQ E+L + V + L
Sbjct: 533 EEAKKKLAQ---RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 589
Query: 1097 ETKLTFEMNIP--KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
+ + F+ + KT+ + +E ++ ++ + + E +E
Sbjct: 590 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE-ALDQLETVKREN 648
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
L+++ A L ++ E I +LE ++ Q + + ++ LE + +
Sbjct: 649 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 708
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYEQLL 1272
+ +++S I + ++ EI +L + + E + E+R + A + K E L
Sbjct: 709 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 768
Query: 1273 DSVQSSTQEETNKIV-TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILR 1324
+ ++ + T++ + S+Q +L+D + HL +L+E+ A V + +L+
Sbjct: 769 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ 828
Query: 1325 SEIEDEKVAFXXXXXXXXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLK 1378
+E+E+ + L T+N S +++ ++ + ++++
Sbjct: 829 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVE 888
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFEN 1436
+S + DA EL + + E +K E T+ L R DE E
Sbjct: 889 DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 948
Query: 1437 V-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVK 1486
+ ++Q+ + E RI +L +E E E ++ L+ +E T Q E + + V
Sbjct: 949 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1008
Query: 1487 LIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
+++L K+ V S +Q E ++ + K + Q LE E ++ L+
Sbjct: 1009 RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1068
Query: 1546 MVR-ASSSKIQKHVS 1559
R +SS++ H S
Sbjct: 1069 KTRDFTSSRMVVHES 1083
Score = 101 bits (241), Expect = 3e-20
Identities = 183/934 (19%), Positives = 403/934 (43%), Gaps = 78/934 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLE--AARFEISLE 270
++++ + E + E K + Q+ L D+++++ +++SL + LE E SLE
Sbjct: 126 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 185
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++SI +K +++E+ + +L K+E
Sbjct: 186 QEKKLRVDLERNKRKLEGDLK----LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 241
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q ++ KEL+ ++ + E +A + K + K + A +++ +L
Sbjct: 242 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-----TEKQRSDYARELEELSERL 296
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS--EKDTXXXXXXXXXXGKDT 447
T ++NK A+ + + L + + E +++ K +
Sbjct: 297 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNL 356
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKL 505
+ +LE ++ + + ++ E V++ E++ + L D++ + K ++ L
Sbjct: 357 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 416
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQ--MQKTIDNFSKVSDSNKEIVRLT 561
Q ++L E ++ + + +S + + KQ Q+T + ++ + NK L
Sbjct: 417 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 476
Query: 562 EELHH-------LSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMIEME--- 606
L L ++ E +E K LQ L +S E+D ++ E+E
Sbjct: 477 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 536
Query: 607 -NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
LA+ + +E+ Q+ EVED + D+ + S + K + +
Sbjct: 537 KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 596
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
+ + +E +E + L + L+N E+ +++L+ +EN +L ++
Sbjct: 597 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 656
Query: 726 KMSAEKISELLAKINHEEQSKIQTQF---GIDAKIQERDLYIEN-------IESELSKYK 775
++ E+I+E I+ E+S+ Q + I ++E + +E+ I+ EL++ K
Sbjct: 657 DLT-EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 715
Query: 776 SRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLM 831
S I R + E +E + + +R + + S L + ++ +E + ++ +N + + +
Sbjct: 716 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 775
Query: 832 DH--DRVVE--KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--R 885
H + E K L ++ + K+ Q L ++L+ L+ +++ N L + R
Sbjct: 776 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELR 835
Query: 886 TDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
L ++E + + L+SN + ++ H T ++ KK++E ++ +++E A RD +
Sbjct: 836 ATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 895
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
EK +K I + +L++ ++ +L E K NLE K +Q + ++
Sbjct: 896 NAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQLA 950
Query: 1005 -EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ +I KL +++ + E+ QK N V + YE ++ + T + E +
Sbjct: 951 LKGGKKQIQKLETRIRELEFELEG-EQKKNTESVKGL---RKYERRVKELTYQSEEDRKN 1006
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ R+ + L+D +LQ+ V+ Q +E E
Sbjct: 1007 VLRL-QDLVD------KLQVKVKSYKRQAEEADE 1033
Score = 97.1 bits (231), Expect = 5e-19
Identities = 164/877 (18%), Positives = 367/877 (41%), Gaps = 51/877 (5%)
Query: 473 EDVN-EIAKVQEQLKQELNDEIKDVNVKDL----IEKLKSA-EEQITQLNDEIDAANKNM 526
E++N E+ + +L+ E ++ KD++ +L +EK K A E ++ L +E+ ++ +
Sbjct: 76 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI 135
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K+ K + Q+ +D+ D ++ L + L Q+V +LE + V
Sbjct: 136 AKLTREKKALQEAHQQALDDLQAEED---KVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 192
Query: 587 DYDSG-RMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
D + R +E D+ + +L + + L+ + F+ Q LQ K VED+
Sbjct: 193 DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ----LQSK---VEDEQT 245
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q Q + + LEE+I+A A++ + + + E+L +++
Sbjct: 246 LGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST 305
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
+ + E + L LE+ + + ++A + + + + +I +
Sbjct: 306 QIELNKKREAEFLKLRRDLEEATLQH-EAMVATLRKKHADSVAE---LGEQIDNLQRVKQ 361
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+E E S++K I L S+ + + +LE+ L L E + E EL
Sbjct: 362 KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTT 421
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE--KA 883
+ + L + +QL E E +L + Q ++ + L+ L + + NAL ++
Sbjct: 422 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQS 481
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
+R D + +Y+ + ++ ++ L+R + + + Q + + E I+ ++E A +
Sbjct: 482 SRHD-CDLLREQYEEE-QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 539
Query: 944 KVLNEKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ E+ +E V LE Q + +E+L ++VE N + L K+Q
Sbjct: 540 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL-----DKKQRN 594
Query: 1000 SPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
++ + + A L+ +E +L+ ++ + +Y + E+ + +N
Sbjct: 595 FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET----VKRENKN 650
Query: 1060 MEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE 1119
+E+E+ +++Q+ ++ + EL+ ++ + + +++ E + E I+ +E
Sbjct: 651 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 710
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLE 1179
++ + +D LK + +S L + N ++ L
Sbjct: 711 -LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 769
Query: 1180 TLNTELTGHDVVNQEQINQLKS---KLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+ +L+ + E + L+S +L+ D+ L +L+ + + V++R A
Sbjct: 770 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL-AIVERR----A 824
Query: 1237 ELWKQHLAQREADFQKTE--HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTS 1294
L + + + A ++TE +L Q ++ QLL + +S K+ T +
Sbjct: 825 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET--DLMQ 882
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
LQ++++D RN +EK I ++ E++ E+
Sbjct: 883 LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 919
Score = 95.9 bits (228), Expect = 1e-18
Identities = 198/1020 (19%), Positives = 431/1020 (42%), Gaps = 106/1020 (10%)
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPS 303
++KD ++ E K LE + E + L +++ L K +
Sbjct: 4 KTKD-ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLE 62
Query: 304 CEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPS 363
+ K E+ E+ E ELT K LE ++++ +LE LA + E A +
Sbjct: 63 AKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 121
Query: 364 KKGSPLIS------RKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
K + +S K R + ++ L +D +NK + +KLE ++ L
Sbjct: 122 KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK-SKLEQQVEDL 180
Query: 418 NKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLI----AQLQLEHQQHMEGPSLIHVGTNT 472
L +K+ + + +++++ + QL+ + + + +
Sbjct: 181 ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 240
Query: 473 EDVNEIA-KVQEQLK------QELNDEIK-DVNVKDLIEKLKS-AEEQITQLNDEI-DAA 522
ED + + Q+++K +EL +EI+ + + EK +S ++ +L++ + +A
Sbjct: 241 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 300
Query: 523 NKNMIKVKSNHK-----LKLKQ--MQKTIDNFSKVSDSNKE----IVRLTEELHHLSQKV 571
+++ N K LKL++ + T+ + + V+ K+ + L E++ +L +
Sbjct: 301 GVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK 360
Query: 572 AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM-----ENLAETRLK------AISLLE 620
+LE+EK +L + D S S + ++ + L+E R K ++S L
Sbjct: 361 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 420
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
+QK L E L + ++E+K + +SQL + ++ L+ Q++ + +K LA
Sbjct: 421 TQKSRLQTEAGELSR---QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 477
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+++ + D + L ++ + K ++ L E K E + ++ EL
Sbjct: 478 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL----- 532
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
EE K Q ++Q+ + +E + ++ + + RL+ + ED +ER A+
Sbjct: 533 -EEAKKKLAQ-----RLQDSEEQVEAVNAKCASLEKTKQRLQGEV---EDLMVDVER-AN 582
Query: 801 QLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
L + L +KQ K +E+ + +E L + R + +L ++++ +E + +
Sbjct: 583 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE 642
Query: 857 ILLEENQNLQISLSDMQQHY----NALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
+ EN+NL+ ++D+ + + E E E Q L + E+ L+ H
Sbjct: 643 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE---H 699
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-TQLEAQLQEYKNNI 971
E + I++ + E+ ++ E + +I + + L Y++ +E + + L+A+++ +N
Sbjct: 700 E-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRS-RNEA 757
Query: 972 ENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ 1030
L +E +LN++ ++L H +Q ++ + ++ L ++ + +
Sbjct: 758 IRLKKKMEGDLNEIEIQL--SHANRQAAETLKHLRSVQGQLKDTQLHL----DDALRGQE 811
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ + ++++ + LE E + ++LLDS NE +Q+L
Sbjct: 812 DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS---NERVQLL----HT 864
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
Q L TK E T+ M + S +E S DA N + + + ++E
Sbjct: 865 QNTSLIHTKKKLE-----TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE- 918
Query: 1151 IQERSV-LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
Q+ S L+ L +++ ++ + E L L G ++QI +L++++ +L E
Sbjct: 919 -QDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKG----GKKQIQKLETRIRELEFE 971
Score = 87.4 bits (207), Expect = 4e-16
Identities = 165/828 (19%), Positives = 335/828 (40%), Gaps = 94/828 (11%)
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
E K K + + E +E++ +L ++ + L +Q + + + + D+L+
Sbjct: 1 EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 60
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
L + V ++ + E N EL K + L +E L+ + D++ A VEK
Sbjct: 61 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL-AKVEKEKHA--T 117
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
E++ +L L+ + ++T E + L ++ ++DL+ E E + K
Sbjct: 118 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE-----EDKVNSLNKTKSK 172
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
E+ +E LE+ L++ K +L N +L +L+L + + + N
Sbjct: 173 LEQQVE---DLESSLEQEKKLRVDLERNKRKLEG-DLKLAQESILDLE-----------N 217
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
+ +L+ LK+KD E L K+ + Q ++ ++ K+ + ++E +EEE++ ++
Sbjct: 218 DKQQLDERLKKKDFEYCQLQSKVEDEQ----TLGLQFQKKIKELQARIEELEEEIE--AE 271
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +K +++ D +EL+E E G + S+ IE
Sbjct: 272 RATRAKTE--------KQRSDYARELEELSERLE-----EAGGVTSTQIE---------- 308
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L+ EE +Q +++ K + E +I L+ + +L
Sbjct: 309 -LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 367
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ +I+ L S +E ++ NL L +S A + E + L +++
Sbjct: 368 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN--EEIQRSLSELTTQKSR 425
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
Q EL QL ES QL S Q+ TQ Q L+ +L+++ + L
Sbjct: 426 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQ----------QTEELKRQLEEENKAKNAL 475
Query: 1310 QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN 1369
+ ++LR + E+E+ +E ++ E +
Sbjct: 476 AHALQSSRHDCDLLREQYEEEQEG--------KAELQRALSKANSEVAQWRTKYETDAIQ 527
Query: 1370 INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL---ELKDSEI-YQKTHEYTI 1425
EE + KK VN A+ LE T Q E++D + ++ +
Sbjct: 528 RTEELEEAKKKLAQRLQDSEEQVEAVN-AKCASLEKTKQRLQGEVEDLMVDVERANSLAA 586
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELA---ILRLKMHENANHYETM--QKES 1480
L ++ F+ V L E++ + E+ E E+ L L ++ + N YE Q E+
Sbjct: 587 ALDKKQRNFDKV---LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET 643
Query: 1481 EIERVKLIEELNVKITESVSLN-KQVAELNKALEE-EVAKTN------EMQTALENQEIE 1532
K +E+ +TE ++ N K + EL K+ ++ E+ K + E + ALE++E +
Sbjct: 644 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 703
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
I+ + E+T +++ + ++ + + Q E + + ++ E+
Sbjct: 704 ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 751
Score = 77.4 bits (182), Expect = 4e-13
Identities = 165/893 (18%), Positives = 366/893 (40%), Gaps = 67/893 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD LQ K++ +T L Q+KI E IE +
Sbjct: 218 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 277
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E + + K+R + E +R LEEA EA
Sbjct: 278 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLR-RDLEEATLQHEA 333
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEE-KGSLEIAN 320
+ +H+ EL + KQ +E E K EI++ S+E +
Sbjct: 334 MVATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEFKLEIDDLSSSMESVS 385
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKSGRN 377
++ L K LE + R N+E++ L+ + T+ S+ + + L ++S +
Sbjct: 386 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 445
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q + E Q ++ KN +A + + DL+ ++Y E+
Sbjct: 446 QLSRSKQAFTQQTEELKRQLEEENKAKNALAH-ALQSSRHDCDLLREQY--EEEQEGKAE 502
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
++ +AQ + +++ TE++ E K Q Q+ ++++ VN
Sbjct: 503 LQRALSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN 554
Query: 498 VK-DLIEKLKS-AEEQITQLNDEIDAAN----------KNMIKVKSNHKLKLKQMQKTID 545
K +EK K + ++ L +++ AN +N KV + K K ++ Q ++
Sbjct: 555 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELE 614
Query: 546 NFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY-----DSGRMI-ESDV 598
K S S + E+ +L ++ ++ E NL+ + D ++G+ I E +
Sbjct: 615 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK 674
Query: 599 YKKMIEMENLAETRL---KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV 655
+K IE+E A+ +L +A + LE ++ +++ L Q E++ K+A + D+
Sbjct: 675 SRKQIELEK-ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA-----EKDEE 728
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
++K + SA E+ E ++L K+++ G + ++E + ++
Sbjct: 729 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKKMEGDLNEIEIQLSHANRQAAETLK 787
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESELSK 773
+ +L+ L + + +EQ I + + A+++E +E E
Sbjct: 788 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 847
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
+ + E + ++ + SL +L + L + Q + + + +
Sbjct: 848 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 907
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
++ ++L + + + L++ + L + ++LQ L + +Q L K + + + E
Sbjct: 908 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ----LALKGGKKQIQKLE- 962
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
T+ + +LE K+ T + L + ++ +++L + ++ +R + ++++ K
Sbjct: 963 TRIRELEFELEGEQKKNTESVKGL-RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1021
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYT 1004
Y Q E ++ ++ EL + ++ + V K + ++ D+T
Sbjct: 1022 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 1074
Score = 72.9 bits (171), Expect = 9e-12
Identities = 96/457 (21%), Positives = 208/457 (45%), Gaps = 43/457 (9%)
Query: 468 VGTNTEDVNEIAKVQEQLKQELND-----EIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
+ N + ++E+ K ++Q++ E D E + ++ K+ + ++TQ+ EID
Sbjct: 662 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID-- 719
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
K K + +LK + Q+T++ D+ VR E L +K +E + ++
Sbjct: 720 RKIAEKDEEIEQLK-RNYQRTVETMQSALDAE---VRSRNEAIRLKKK---MEGDLNEIE 772
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD---- 638
+ L + + + E+ + + ++ + L +T+L L Q+ DL ++L I++++ +
Sbjct: 773 IQL-SHANRQAAETLKHLRSVQGQ-LKDTQLHLDDALRGQE-DLKEQLAIVERRANLLQA 829
Query: 639 EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
EVE+ A + Q + + +E + + E++ L L + L+ D QL ++D
Sbjct: 830 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 889
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
D + K + I + + ++L+K + A + +++ QT + ++
Sbjct: 890 ASRDARNAEEKAKKAITDAAMMAEELKKEQ-----DTSAHLERMKKNLEQTVKDLQHRLD 944
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
E + + L K +I +LE I +E ++K + L++ ++ E T
Sbjct: 945 EAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTY 998
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
Q +E +R VL D +V+K ++++ ++ ++ +E N ++ QH
Sbjct: 999 QSEE--DRKNVLRLQD-LVDKLQVKVKSYKRQAEEA-----DEQANAHLTKFRKAQH--E 1048
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
L E R D+AES+ K + + RD S+ + + HE +
Sbjct: 1049 LEEAEERADIAESQVNKLRAKTRDFTSS-RMVVHESE 1084
Score = 37.5 bits (83), Expect = 0.40
Identities = 67/352 (19%), Positives = 134/352 (38%), Gaps = 27/352 (7%)
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
+FQKT+ EL + + E+L+ VQ + E + + + +
Sbjct: 1 EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 60
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR---TENQSYKQMQEQ 1365
L+ K +V + E EI E A DL + + K E
Sbjct: 61 LEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 119
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ-KTHEYT 1424
+ N+ EE + L ++ E K L+ HQ L D + + K +
Sbjct: 120 KVKNLTEELSGLDETIAKLT------------REKKALQEAHQQALDDLQAEEDKVNSLN 167
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILR---LKMHENANHYETMQK 1478
T ++ + E++ L + +K DL K E +L + + L + + + K
Sbjct: 168 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 227
Query: 1479 ESEIERVKLIEELNVKITESVSLNKQVAELN---KALEEEVAKTNEMQTALENQEIEIVT 1535
+ + E +L ++ + T + K++ EL + LEEE+ + E Q +
Sbjct: 228 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 287
Query: 1536 LNDEIT-NLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPR 1586
+E++ L+ +S++I+ + ++ + R + + T+ E + A R
Sbjct: 288 ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR 339
>BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 116 bits (280), Expect = 5e-25
Identities = 194/953 (20%), Positives = 410/953 (43%), Gaps = 78/953 (8%)
Query: 234 DEKQRLLKD----IESKDVRISSLEEANKLLE-AARFEISLEHSKLAQELEQXXXXXXXX 288
+E++R ++D +E + + LE+ +++ E + LEH+++ +ELEQ
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARI-KELEQSLLFEKTK 490
Query: 289 XXXXXXLAKQSIEPSCEEKT---EIEEKGSLEIANMTELTKKIELLE-----HLNCQIRQ 340
+ + + EK+ E+E+ +L + + EL +++E + ++ + Q
Sbjct: 491 ADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ 550
Query: 341 TNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS--SETLNQDT 398
L+ KL T+ + + K+ ++ + + + +LS +E+L
Sbjct: 551 EISSLQEKLEVTRTDHQREITSLKEHFGA-REETHQKEIKALYTATEKLSKENESLKSKL 609
Query: 399 D--KKINKNEIA----KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQL 452
+ K N + IA KLE I S + + + + S+ T I ++
Sbjct: 610 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK---GLGTETAEFAELKTQIEKM 666
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ- 511
+L++Q +E E+ ++ +L + + + K+ +++ + KL AE+Q
Sbjct: 667 RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE--KENSLEAIRSKLDKAEDQH 724
Query: 512 ITQLNDEIDAANKNMIKVKSNHKLKLK--QMQKTIDNF-SKVSDSNKEIVRLT------- 561
+ ++ D ++ + IKVK L+ K + K IDNF S++ + ++++ L
Sbjct: 725 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 784
Query: 562 ---EELHHLSQKVAELEEEKGNLQLHL-VDYDSGRMIESDVYKKMIEMENLAETRLKAIS 617
E+ L Q++ E++ +L++ + I ++ + +++ NL E +S
Sbjct: 785 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN----LS 840
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
+ K L +EL IL++K+ E ++ + + + V K EEQ + LS+ ++
Sbjct: 841 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN---KLHQKEEQFNMLSSDLEK 897
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
L ENL D E + + E KL+N I E M ++ + EL
Sbjct: 898 LR---ENLA-DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 953
Query: 738 KINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
K E+ +++ T+ +A ++ + +++E S+ ++ + EE +E + LE
Sbjct: 954 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLE 1012
Query: 797 RKADQLGSYLQEKQKAYSEYTIQ-----EDELVNRLAVLMDHDRVVEKQLLEIEHENKEL 851
+K + + QE + Y T + E+ L N L+D + ++ E +EL
Sbjct: 1013 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1072
Query: 852 Q--KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLK 908
+ +K + Q + ++ M+Q E + + + K Q +L L E+NLK
Sbjct: 1073 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1132
Query: 909 RIT--HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
+ ++ + L+ + +++E+ E T ++A + + L+ E+N++ +L E
Sbjct: 1133 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE 1192
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
++ + L LN LE+ K K + + I+ +ALL +KD E+
Sbjct: 1193 VTSH-QKLEEERSVLNNQLLEM-KKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1250
Query: 1027 ALNQKI------NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE- 1079
L ++ N + S S+V ES + K++N+E +++ +QL S + +
Sbjct: 1251 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1310
Query: 1080 ELQILVREQDDQIKELKETKLTFE---MNIPKTEGMIISSTIEPMSDDANNVD 1129
+ R Q+ QI L + + ++ M+ + + DD NN D
Sbjct: 1311 QADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1363
Score = 110 bits (265), Expect = 4e-23
Identities = 183/964 (18%), Positives = 401/964 (41%), Gaps = 83/964 (8%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L++K +E LA+ L+ +V V EQ AL+ + ++ K+D QL
Sbjct: 357 LKEKQQHIEQLLAE-RDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD--QL 413
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS-ELLAKINHEEQSKIQTQF 751
++ + +K +++N+L+ ++ DL ++E+ S K E ++I+ E+ QT+
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQIS-EDPENTQTKL 472
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
A+I+E +E L K++ +L+ + ED R + + S + E +K
Sbjct: 473 E-HARIKE-------LEQSLLFEKTKADKLQREL---EDTRVATVSEK----SRIMELEK 517
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
+ + EL RL V L + E LQ+K ++ ++Q ++
Sbjct: 518 DLALRVQEVAELRRRLESNKPAGDV--DMSLSLLQEISSLQEKLEVTRTDHQR---EITS 572
Query: 872 MQQHYNALVEKANRTDLAESEST-KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
+++H+ A E + A +T K + L+S L+ E+ +I K ++E
Sbjct: 573 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 632
Query: 931 EFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+E + K L + + E TQ+E +Y++ IENL + +
Sbjct: 633 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA--- 689
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALL-KQKDEEIIALNQKINNAQVSYMSM--VSDY 1046
K ++ + + ++ N + + + L K +D+ ++ + +N Q + + + +
Sbjct: 690 -KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 748
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLD-------SKQHNEELQILVREQDDQIKELKETK 1099
++K + T ++N +++ ++LLD S + E++ L ++ + K++K
Sbjct: 749 QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH-- 806
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQ 1158
L E N ++ I+ ++ N+ L ++E + ++E+ +
Sbjct: 807 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL--EKELQILKEKFAEAS 864
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
E++ + +QE K+ Q E L+ +E + +++K + + + L+
Sbjct: 865 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 924
Query: 1219 ELRSSISSAVDQRGFEIAELWKQH--LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
+L + I+ + G ++L K + L +E D + EL+++L+ L S++
Sbjct: 925 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE----ELQLKLTKANENASFLQKSIE 980
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
T V EQ S Q + EE + L+ K +D+ ++E ++ ++ K +
Sbjct: 981 DMT-------VKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1031
Query: 1337 XXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+L Q E + EEN+ L +
Sbjct: 1032 ATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQT 1087
Query: 1397 DAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE 1456
+A +++ Q+ + +E + T + +E + +++ + K +E+L KE
Sbjct: 1088 AEDA--MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL---KNVEELNKSKE 1142
Query: 1457 SELAILRLKMHENANHYETMQKES--EIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
L + KM E ET+++ + + +++ ++E NVK+ E + ++ ++ LEE
Sbjct: 1143 L-LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1201
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
E + N ++ +E + + DE + +QK +S S +D +L+
Sbjct: 1202 ERSVLNNQLLEMKKRESKFIKDADE----------EKASLQKSISITSALLTEKDAELEK 1251
Query: 1575 TMNK 1578
N+
Sbjct: 1252 LRNE 1255
Score = 97.1 bits (231), Expect = 5e-19
Identities = 196/1021 (19%), Positives = 434/1021 (42%), Gaps = 94/1021 (9%)
Query: 347 NKLATMGTESKAVSS-PSKKG-----SPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK 400
+ L++M + + +VSS PS+ G S +RK TA + Q E L + D
Sbjct: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERD- 372
Query: 401 KINKNEIAKLEMVIQSLNKDLV-----DKEYVI---SEKDTXXXXXXXXXXGKDTLIAQL 452
+ + E+AK + + ++L ++V+ ++ D K L+ QL
Sbjct: 373 -LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQL 431
Query: 453 QLEHQQHMEGPSLIHVGTNTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ 511
+ E ++ + + + T+ D+ + +++ E + +++ +K+L + L + +
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLEQKSQISED-PENTQTKLEHARIKELEQSLLFEKTK 490
Query: 512 ITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVS---DSNKEIVRLTEELHHLS 568
+L E++ + KS K + + +++ +SNK + L L
Sbjct: 491 ADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS-LL 549
Query: 569 QKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
Q+++ L+E+ L + D R I S K+ ET K I L + L +
Sbjct: 550 QEISSLQEK-----LEVTRTDHQREITS--LKEHFGARE--ETHQKEIKALYTATEKLSK 600
Query: 629 ELHILQQKYDEVEDKLADI-----SQLQ----SDQVCSEIKSVHLEEQIDALSASKKELA 679
E L+ K + + +D+ S+L+ S Q E V + + +A EL
Sbjct: 601 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK 660
Query: 680 LVIENLKLDKEQLYGTIKDLENDK--------EDIMNKLQNYIQENMD----LTDKLEKM 727
IE ++LD + +++ ++ + E + KL I+E + + KL+K
Sbjct: 661 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA 720
Query: 728 SAEKISELLAKIN--HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE--- 782
+ + E+ +N E + K++ + AK E+ I+N S+L + ++ L+
Sbjct: 721 EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 780
Query: 783 ----ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E + M+ R LE Q+ EK S+ + EL R L + ++
Sbjct: 781 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN----LQ 836
Query: 839 KQLLEIEHENKELQKKNQILLE---ENQNLQISLS-DMQQHYNALVEKANRTDLAESEST 894
+ L E+ + L+K+ QIL E E +S+ MQ+ N L +K + ++ S+
Sbjct: 837 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 896
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
K + L D+E+ + + LI K+K D+ +++ + K +N++
Sbjct: 897 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK-MNDELRLKE 955
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
V +L+ +L + N L ++E++ + E + K+ + E+ ++++ K
Sbjct: 956 RDVEELQLKLTKANENASFLQKSIEDMT-VKAEQSQQEAAKKHEEEKKELERKLSDLEKK 1014
Query: 1015 NALLKQKDEEIIALNQK-INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
+ +E+ A ++ + + + ++ + + L KL+ EE + ++L +
Sbjct: 1015 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1074
Query: 1074 SKQHNEELQILVREQDD-QIKE---LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
++ ++ + +D QI E ++T+ + K + + ++ + ++ N +
Sbjct: 1075 LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN-NLKN 1133
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNTEL 1185
++ Q+ EEF +E L++ +A+ + + LQE K+ +L E+
Sbjct: 1134 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1193
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
T H + +E+ + L ++L ++ + E ++S+ ++ + L +
Sbjct: 1194 TSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSI--------SITSALLTE 1244
Query: 1246 READFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEH 1305
++A+ +K +E+ V L + + L VQ+ E++K+ +V +L+ +L++ +
Sbjct: 1245 KDAELEKLRNEVTV-LRGENASAKSLHSVVQTL---ESDKVKLELKVKNLELQLKENKRQ 1300
Query: 1306 L 1306
L
Sbjct: 1301 L 1301
Score = 61.7 bits (143), Expect = 2e-08
Identities = 116/623 (18%), Positives = 255/623 (40%), Gaps = 61/623 (9%)
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+Q+ + + EQ + E + A + + + + Q++ A+ + V + E+K+ Q
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
T +E + E + QL + K+ E+LQ V E+ +L++ K++
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQ----------KSQ-- 460
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEFIQERSVLQEQSAKLNTELQEC 1171
+S+D N +++E E+ + E++ ++ KL EL++
Sbjct: 461 --------ISEDPENTQTKLEHA-------RIKELEQSLLFEKT----KADKLQRELEDT 501
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND-----NLLSTVAELRSSISS 1226
+ ++ EL + +++ +L+ +LE D +LL ++ L+ +
Sbjct: 502 RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 561
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
EI L K+H RE QK L + E L ++ + +E ++ I
Sbjct: 562 TRTDHQREITSL-KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 620
Query: 1287 VTMEQ--VTSLQNKLQDKEE-------HLRNLQEKYADVINQIEILRSEIEDEKVAFXXX 1337
+ T++ + Q EE L ++A++ QIE +R + + E
Sbjct: 621 ALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ 680
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
LR + + +E S+ I ++L K+ ++ +
Sbjct: 681 QDSERAAHAKEMEALRAKLMKVIKEKENSLEAI---RSKLDKAEDQHLVEMEDTLNKLQE 737
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTITLTQRND---EFENVRQQLVEYEKRIEDLTYE 1454
AE KV EL L+ K +E + +T L + + + +R+ E + ++ L +
Sbjct: 738 AEIKVKEL-EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ 796
Query: 1455 KE-SELAILRLKMHENANHYETMQKESEIERVKL-IEELNVKITESVSLNKQVAELNKAL 1512
E +E I L++ +NA + E++ +L + L ++E + + + + + L
Sbjct: 797 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL 856
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
+E+ A+ +E +++ E V + NM+ + K++++++ + +DE+
Sbjct: 857 KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER- 915
Query: 1573 DNTMNKELLDAVPRAELDLAMYM 1595
++L+ A + E D+A M
Sbjct: 916 ----EEQLIKAKEKLENDIAEIM 934
Score = 58.4 bits (135), Expect = 2e-07
Identities = 132/690 (19%), Positives = 279/690 (40%), Gaps = 75/690 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMK--------IMETTILDLQE-------------KINEKDQI 185
L IKEK+N+L ++ K+ ME T+ LQE K NE+ ++
Sbjct: 699 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 758
Query: 186 IE---AKNKATTXXXXXXXXXXXXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQR- 238
I+ ++ KAT + K QQ+ ++ +E E E +
Sbjct: 759 IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 818
Query: 239 --LLKDIESKDVRISSLE----EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXX 292
+ ++++ +++++++L+ E +++ E E+ + K A+ E+
Sbjct: 819 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 878
Query: 293 XXLAKQ---------SIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK 343
L ++ +E E ++E K + +L K E LE+ +I + +
Sbjct: 879 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 938
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+ ++L M E + + + L K+ N + KS +Q K +
Sbjct: 939 DNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 997
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXXXXXXXGKDTLIAQLQ---LEHQQH 459
+ E +LE + L K + E K + ++ LQ L+ +
Sbjct: 998 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1057
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLK--QELND--EIKDVNVKDLIEKLKSAE---EQI 512
++G + G +++ E+ K ++ K Q D +I + K+ E L S E +
Sbjct: 1058 LKGAREENSGL-LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1116
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
+L +E+D +N +K+ +L + T++N K+ + KEI L + SQ+++
Sbjct: 1117 AKLQNELDTLKEN--NLKNVEELNKSKELLTVEN-QKMEEFRKEIETLKQAAAQKSQQLS 1173
Query: 573 ELEEEKGNLQLHLVDYDSGR-MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
L+EE L L GR E ++K+ E ++ +L + ES+ E
Sbjct: 1174 ALQEENVKLAEEL-----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1228
Query: 632 ILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
QK + L + +++ +E+ + E +AS K L V++ L+ DK +
Sbjct: 1229 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------NASAKSLHSVVQTLESDKVK 1282
Query: 692 LYGTIKDLENDKEDIMNKLQN---YIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KI 747
L +K+LE ++ +L + D ++ ++ + ++ ++ + + Q K+
Sbjct: 1283 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1342
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSR 777
+ + +A + + N +S+ + +S+
Sbjct: 1343 KVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1372
Score = 52.4 bits (120), Expect = 1e-05
Identities = 124/648 (19%), Positives = 249/648 (38%), Gaps = 63/648 (9%)
Query: 4 TKNIDH-PSEMELSEETTARLPSSEVSSVAGXXXXXXXXXXXXXXXERQIKFERAQKCLE 62
TK ID+ S+++ +EE L + +S G E+QIK +K E
Sbjct: 756 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLEIEKNAE 814
Query: 63 NAALVSKRIKEHRKATAELLGRPF-VPGISESLANTLKQKEILMEKIKQYKELSKRSSTT 121
++ S T EL GR + + E+L+ + KE L ++++ KE +S
Sbjct: 815 SSKASS--------ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 866
Query: 122 IVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINE 181
V + N + +K+ ++L ++ + + D++ K E
Sbjct: 867 AVSVQRS---------------MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 911
Query: 182 KD----QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQ 237
KD Q+I+AK K D Q+TKM + E + ++ +
Sbjct: 912 KDEREEQLIKAKEKLENDIAEIMKMSG--------DNSSQLTKMNDELRLKERDVEELQL 963
Query: 238 RLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAK 297
+L K E+ S+E+ E ++ E + +H + +ELE+ +
Sbjct: 964 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD-----------LE 1012
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESK 357
+ +E S + E+ K E A TK E+L++L ++T + E+KL E+
Sbjct: 1013 KKMETSHNQCQEL--KARYERATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENS 1066
Query: 358 AVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ ++ + TA Q++ E + K AKL+ + +L
Sbjct: 1067 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1126
Query: 418 NK-DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN 476
+ +L + E + K+ + + Q Q+ + +L N +
Sbjct: 1127 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAE 1184
Query: 477 EIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
E+ + ++++ Q+L +E +N L+E K + I ++E + K++ +
Sbjct: 1185 ELGRSRDEVTSHQKLEEERSVLN-NQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1243
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K +++K + + + N L + L +LE + NL+L L ++ R +
Sbjct: 1244 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL--KENKRQL 1301
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
S + + + I L S DL ++ L+ K + + +
Sbjct: 1302 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1349
Score = 49.2 bits (112), Expect = 1e-04
Identities = 105/582 (18%), Positives = 225/582 (38%), Gaps = 32/582 (5%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+ HL + + S + +++ E + +LQE ++E Q+ E K
Sbjct: 804 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 863
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
++ + K+ + + ++L +++ + + +E + L A
Sbjct: 864 SEEAVSVQRSMQETVNKLHQKEEQFNM-LSSDLEKLRENLADMEAKFREKDEREEQLIKA 922
Query: 264 RFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+ ++ + +++ ++ L ++ +E + T+ E S ++ +
Sbjct: 923 KEKLENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 981
Query: 324 LTKKIELLEHLNC-QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+T K E + + + KELE KL+ + + + + ++ R + T +K
Sbjct: 982 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS-ETKTKH 1040
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ L L+ + K + E + L ++ L K DK +
Sbjct: 1041 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-ADKAKAAQTAEDAMQIMEQMT 1099
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHV--GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD 500
K +A L+ Q + + + + N ++V E+ K +E L E N ++++ +
Sbjct: 1100 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE-NQKMEEFRKE- 1157
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
IE LK A Q +Q + N + + + ++ QK + S +++ +L
Sbjct: 1158 -IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN------QL 1210
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK-------MIEMENLAETRL 613
E S+ + + +EEK +LQ + S + E D + ++ EN + L
Sbjct: 1211 LEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL 1269
Query: 614 -KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
+ LES K L ++ L+ + E + +L+ S Q + ++ E QID L+
Sbjct: 1270 HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA--QESQIDFLN 1327
Query: 673 ASKKELALVIENLKLDKEQ-----LYGTIKDLENDKEDIMNK 709
+ +L ++LK+ E L G DL N D K
Sbjct: 1328 SVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEK 1369
>AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical
rhabdomyosarcoma antigen MU-RMS-40.3 protein.
Length = 941
Score = 116 bits (280), Expect = 5e-25
Identities = 203/973 (20%), Positives = 418/973 (42%), Gaps = 88/973 (9%)
Query: 639 EVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIK 697
E + D Q + D+V S K+ LE+Q++ L +S ++ + +L+ +K +L G +K
Sbjct: 3 EAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 62
Query: 698 -------DLENDKEDIMNKLQNYIQENMDLTDKLEKMSA------EKISELLAKINHEEQ 744
DLENDK+ + +L+ E L K+E +KI EL A+I E +
Sbjct: 63 LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI-EELE 121
Query: 745 SKIQTQFGIDAKIQ-ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
+I+ + AK + +R Y +E ELS+ RLEE+ V + L +K +
Sbjct: 122 EEIEAERATRAKTEKQRSDYARELE-ELSE------RLEEAGGV-TSTQIELNKKRE--A 171
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE--KQLLEIEHENKELQKKNQILLEE 861
+L + ++ E T+Q + +V L D V E +Q+ ++ ++L+K+ E
Sbjct: 172 EFL-KLRRDLEEATLQHEAMVATLR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 229
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK 921
+L S+ + + A +EK RT E + ++ + + +++ +L +T + L +
Sbjct: 230 IDDLSSSMESVSKS-KANLEKICRT--LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEA 286
Query: 922 KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
+ LE E + + R K+ ++ E +L+ QL+E +N +N + +
Sbjct: 287 GELSRQLE-EKESIVSQLSRSKQAFTQQTE-------ELKRQLEE-ENKAKNALAHALQS 337
Query: 982 NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYM 1040
++ + +L+ + +++Q + ++ +++ N A + K E + I +++ A+
Sbjct: 338 SRHDCDLLREQYEEEQEGKAE-LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 396
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQR----VSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ D E ++ K ++E+ QR V ++D ++ N L ++Q + K L
Sbjct: 397 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 456
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
E K E + + E + S +S + + +K +E + QE +
Sbjct: 457 EWKTKCEESQAELEASLKES--RSLSTELFKLKNAYEEALDQLETVK-RENKNLEQEIAD 513
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
L EQ A+ + E Q+E ++ Q + + ++ LE + +
Sbjct: 514 LTEQIAENGKTIHELEKSRKQIELEKADI-------QLALEEAEAALEHEEAKILRIQLE 566
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYEQLLDS 1274
+ +++S I + ++ EI +L + + E + E+R + A + K E L+
Sbjct: 567 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNE 626
Query: 1275 VQSSTQEETNKIV-TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILRSE 1326
++ + T++ + S+Q +L+D + HL +L+E+ A V + +L++E
Sbjct: 627 IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAE 686
Query: 1327 IEDEKVAFXXXXXXXXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLKKS 1380
+E+ + L T+N S +++ ++ + ++++ +
Sbjct: 687 VEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDA 746
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV- 1437
S + DA EL + + E +K E T+ L R DE E +
Sbjct: 747 SRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 806
Query: 1438 ----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLI 1488
++Q+ + E RI +L +E E E ++ L+ +E T Q E + + V +
Sbjct: 807 LKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRL 866
Query: 1489 EELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
++L K+ V S +Q E ++ + K + Q LE E ++ L+
Sbjct: 867 QDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKT 926
Query: 1548 R-ASSSKIQKHVS 1559
R +SS++ H S
Sbjct: 927 RDFTSSRMVVHES 939
Score = 100 bits (240), Expect = 4e-20
Identities = 180/914 (19%), Positives = 395/914 (43%), Gaps = 75/914 (8%)
Query: 233 KDEKQRLLKDIESKDVRISSLEEANKLLE--AARFEISLEHSK-LAQELEQXXXXXXXXX 289
++ Q+ L D+++++ +++SL + LE E SLE K L +LE+
Sbjct: 2 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 61
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
LA++SI +K +++E+ + +L K+E + L Q ++ KEL+ ++
Sbjct: 62 K----LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 117
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
+ E +A + K + K + A +++ +L T ++NK A+
Sbjct: 118 EELEEEIEAERATRAK-----TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 172
Query: 410 LEMVIQSLNKDLVDKEYVIS--EKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
+ + L + + E +++ K + + +LE ++ +
Sbjct: 173 FLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD 232
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKLKSAEEQITQLNDEIDAANKN 525
+ ++ E V++ E++ + L D++ + K ++ L Q ++L E ++
Sbjct: 233 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 292
Query: 526 MIKVKS--NHKLKLKQ--MQKTIDNFSKVSDSNKEIVRLTEELHH-------LSQKVAEL 574
+ + +S + + KQ Q+T + ++ + NK L L L ++ E
Sbjct: 293 LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEE 352
Query: 575 EEEKGNLQLHLVDYDS-----GRMIESDVYKKMIEME----NLAETRLKAISLLESQKFD 625
+E K LQ L +S E+D ++ E+E LA+ + +E+
Sbjct: 353 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAK 412
Query: 626 LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENL 685
Q+ EVED + D+ + S + K + ++ + +E +E
Sbjct: 413 CASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAS 472
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
+ L + L+N E+ +++L+ +EN +L ++ ++ E+I+E I+ E+S
Sbjct: 473 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLT-EQIAENGKTIHELEKS 531
Query: 746 KIQTQF---GIDAKIQERDLYIEN-------IESELSKYKSRICR-LEESIAVMEDRRYS 794
+ Q + I ++E + +E+ I+ EL++ KS I R + E +E + +
Sbjct: 532 RKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRN 591
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDH--DRVVE--KQLLEIEHE 847
+R + + S L + ++ +E + ++ +N + + + H + E K L ++ +
Sbjct: 592 YQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ 651
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESESTKYQTQLRDLES 905
K+ Q L ++L+ L+ +++ N L + R L ++E + + L+S
Sbjct: 652 LKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS 711
Query: 906 NLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
N + ++ H T ++ KK++E ++ +++E A RD + EK +K I + +L
Sbjct: 712 NERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL 771
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQKDE 1023
++ ++ +L E K NLE K +Q + ++ + +I KL +++ +
Sbjct: 772 KKEQDTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 826
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
E+ QK N V + YE ++ + T + E + + R+ + L+D +LQ+
Sbjct: 827 ELEG-EQKKNTESVKGL---RKYERRVKELTYQSEEDRKNVLRL-QDLVD------KLQV 875
Query: 1084 LVREQDDQIKELKE 1097
V+ Q +E E
Sbjct: 876 KVKSYKRQAEEADE 889
Score = 84.6 bits (200), Expect = 3e-15
Identities = 143/789 (18%), Positives = 329/789 (41%), Gaps = 42/789 (5%)
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSG----RMIESDVYKKMIEMENLAETRLKAIS 617
++L KV L + K L+ + D +S + + D+ + ++E + ++I
Sbjct: 10 DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 69
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQL--QSDQVCSEIKS--VHLEEQIDALSA 673
LE+ K L + L +Y +++ K+ D L Q + E+++ LEE+I+A A
Sbjct: 70 DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 129
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
++ + + + E+L +++ + + E + L LE+ + +
Sbjct: 130 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH-E 188
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++A + + + + +I + +E E S++K I L S+ + +
Sbjct: 189 AMVATLRKKHADSVAE---LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 245
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
+LE+ L L E + E EL + + L + +QL E E +L +
Sbjct: 246 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 305
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRIT 911
Q ++ + L+ L + + NAL +++R D + +Y+ + ++ ++ L+R
Sbjct: 306 SKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD-CDLLREQYEEE-QEGKAELQRAL 363
Query: 912 HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV----TQLEAQLQEY 967
+ + + Q + + E I+ ++E A + + E+ +E V LE Q
Sbjct: 364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRL 423
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +E+L ++VE N + L K+Q ++ + + A L+ +E +
Sbjct: 424 QGEVEDLMVDVERANSLAAAL-----DKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 478
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVRE 1087
L+ ++ + +Y + E+ + +N+E+E+ +++Q+ ++ + EL+ ++
Sbjct: 479 LSTELFKLKNAYEEALDQLET----VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 534
Query: 1088 QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE 1147
+ + +++ E + E I+ +E ++ + +D LK +
Sbjct: 535 IELEKADIQLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRKIAEKDEEIEQLKRNYQ 593
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS---KLE 1204
+S L + N ++ L + +L+ + E + L+S +L+
Sbjct: 594 RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 653
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE--HELRVQLS 1262
D+ L +L+ + + V++R A L + + + A ++TE +L Q
Sbjct: 654 DTQLHLDDALRGQEDLKEQL-AIVERR----ANLLQAEVEELRATLEQTERARKLAEQEL 708
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
++ QLL + +S K+ T + LQ++++D RN +EK I +
Sbjct: 709 LDSNERVQLLHTQNTSLIHTKKKLET--DLMQLQSEVEDASRDARNAEEKAKKAITDAAM 766
Query: 1323 LRSEIEDEK 1331
+ E++ E+
Sbjct: 767 MAEELKKEQ 775
Score = 77.4 bits (182), Expect = 4e-13
Identities = 165/893 (18%), Positives = 366/893 (40%), Gaps = 67/893 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD LQ K++ +T L Q+KI E IE +
Sbjct: 74 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 133
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E + + K+R + E +R LEEA EA
Sbjct: 134 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLR-RDLEEATLQHEA 189
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEE-KGSLEIAN 320
+ +H+ EL + KQ +E E K EI++ S+E +
Sbjct: 190 MVATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEFKLEIDDLSSSMESVS 241
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKSGRN 377
++ L K LE + R N+E++ L+ + T+ S+ + + L ++S +
Sbjct: 242 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 301
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q + E Q ++ KN +A + + DL+ ++Y E+
Sbjct: 302 QLSRSKQAFTQQTEELKRQLEEENKAKNALAH-ALQSSRHDCDLLREQY--EEEQEGKAE 358
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
++ +AQ + +++ TE++ E K Q Q+ ++++ VN
Sbjct: 359 LQRALSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN 410
Query: 498 VK-DLIEKLKS-AEEQITQLNDEIDAAN----------KNMIKVKSNHKLKLKQMQKTID 545
K +EK K + ++ L +++ AN +N KV + K K ++ Q ++
Sbjct: 411 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELE 470
Query: 546 NFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY-----DSGRMI-ESDV 598
K S S + E+ +L ++ ++ E NL+ + D ++G+ I E +
Sbjct: 471 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK 530
Query: 599 YKKMIEMENLAETRL---KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV 655
+K IE+E A+ +L +A + LE ++ +++ L Q E++ K+A + D+
Sbjct: 531 SRKQIELEK-ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA-----EKDEE 584
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
++K + SA E+ E ++L K+++ G + ++E + ++
Sbjct: 585 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKKMEGDLNEIEIQLSHANRQAAETLK 643
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESELSK 773
+ +L+ L + + +EQ I + + A+++E +E E
Sbjct: 644 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 703
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
+ + E + ++ + SL +L + L + Q + + + +
Sbjct: 704 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 763
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
++ ++L + + + L++ + L + ++LQ L + +Q L K + + + E
Sbjct: 764 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ----LALKGGKKQIQKLE- 818
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
T+ + +LE K+ T + L + ++ +++L + ++ +R + ++++ K
Sbjct: 819 TRIRELEFELEGEQKKNTESVKGL-RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 877
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYT 1004
Y Q E ++ ++ EL + ++ + V K + ++ D+T
Sbjct: 878 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 930
Score = 66.1 bits (154), Expect = 1e-09
Identities = 127/644 (19%), Positives = 261/644 (40%), Gaps = 75/644 (11%)
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINK 1013
V L + + +E+L ++E+ K+ ++L +++ +K + E + N+ +
Sbjct: 19 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL-ERNKRKLEGDLKLAQESILDLENDKQQ 77
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
L+ LK+KD E L K+ + Q ++ ++ K+ + ++E +EEE++ +++
Sbjct: 78 LDERLKKKDFEYCQLQSKVEDEQ----TLGLQFQKKIKELQARIEELEEEIE--AERATR 131
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
+K +++ D +EL+E E G + S+ IE
Sbjct: 132 AKTE--------KQRSDYARELEELSERLE-----EAGGVTSTQIE-----------LNK 167
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
L+ EE +Q +++ K + E +I L+ + +L +
Sbjct: 168 KREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 227
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
+I+ L S +E ++ NL L +S A + E + L +++ Q
Sbjct: 228 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN--EEIQRSLSELTTQKSRLQTE 285
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKY 1313
EL QL ES QL S Q+ TQ Q L+ +L+++ + L
Sbjct: 286 AGELSRQLEEKESIVSQLSRSKQAFTQ----------QTEELKRQLEEENKAKNALAHAL 335
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ ++LR + E+E+ +E ++ E + EE
Sbjct: 336 QSSRHDCDLLREQYEEEQEG--------KAELQRALSKANSEVAQWRTKYETDAIQRTEE 387
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL---ELKDSEI-YQKTHEYTITLTQ 1429
+ KK VN A+ LE T Q E++D + ++ + L +
Sbjct: 388 LEEAKKKLAQRLQDSEEQVEAVN-AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 446
Query: 1430 RNDEFENVRQQLVEYEKRIEDLTYEKESELA---ILRLKMHENANHYETM--QKESEIER 1484
+ F+ V L E++ + E+ E E+ L L ++ + N YE Q E+
Sbjct: 447 KQRNFDKV---LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 503
Query: 1485 VKLIEELNVKITESVSLN-KQVAELNKALEE-EVAKTN------EMQTALENQEIEIVTL 1536
K +E+ +TE ++ N K + EL K+ ++ E+ K + E + ALE++E +I+ +
Sbjct: 504 NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 563
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
E+T +++ + ++ + + Q E + + ++ E+
Sbjct: 564 QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 607
>BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2,
skeletal muscle, adult protein.
Length = 1941
Score = 116 bits (279), Expect = 7e-25
Identities = 211/1093 (19%), Positives = 437/1093 (39%), Gaps = 84/1093 (7%)
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
K+M + F K+ D E+ + + L +K+ L +EK +LQL + G +
Sbjct: 853 KEMATMKEEFQKIKD---ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVC 656
++I+ + E ++K ++ + ++ EL ++K DE + DI L+
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL----YGTIKDL--ENDKEDIMNKL 710
E + E ++ L+ L I L +K+ L T+ DL E DK + + K
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 711 QNYIQENM-DLTDKLE-----KMSAEKISELL---AKINHEEQSKIQTQ-FGIDAKIQER 760
+ +++ + DL LE +M E+ L K+ E I+ + +D K++++
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQE 820
+ I N++S++ ++ +L++ I ++ R LE + + + + +K S+ + +
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM-QQHYNAL 879
+E+ RL + Q+ + E QK + L E + + + + ++H +++
Sbjct: 1150 EEISERLE---EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 880 VEKANRTD-------LAESESTKYQTQLRDLESNLKRI------------THEHQTLIVQ 920
E + D E E ++ + ++ DL SN++ + T E Q ++
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 921 KKKEIEDLEIEFNTQIESAIR-DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
K+E + I T ++ + + + ++ V+QL Q + IE L +E
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN---KLNALLKQKDEEIIALNQKINNAQ 1036
E K L +Q + EQY E +L L + + E+ K
Sbjct: 1327 EEIKAKNALAHA-LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ----HNEELQILVREQDDQI 1092
+ + + + KLAQ E E + L +KQ E+L + V +
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 1093 KELKETKLTFEMNIP--KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
L + + F+ + K + + +E +A ++ + + E
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE-SLDQLETL 1504
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEN 1210
+E LQ++ + L ++ E +I +LE + ++ Q + + ++ LE +
Sbjct: 1505 KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKI 1564
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
+ + +++S + + ++ EI +L + H+ E+ + E+R + A K +
Sbjct: 1565 LRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Query: 1271 LLDSVQSSTQ-EETNKIV--TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQI 1320
D + Q N++ + + Q L+D + HL +L+E+ A V +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
+L++EIE+ + L T+N S +++ +I++
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRND 1432
+++ + DA EL + + E +K E T+ L R D
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1804
Query: 1433 EFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEI 1482
E E + ++Q+ + E R+ +L E ESE A+ L+ HE T Q E +
Sbjct: 1805 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1864
Query: 1483 ERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT 1541
+ + +++L K+ V S +Q E + +AK ++Q LE E ++
Sbjct: 1865 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Query: 1542 NLQNMVRASSSKI 1554
L+ R +K+
Sbjct: 1925 KLRVKSREVHTKV 1937
Score = 106 bits (254), Expect = 8e-22
Identities = 220/1099 (20%), Positives = 466/1099 (42%), Gaps = 106/1099 (9%)
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K AE E+E ++ + + I+ ++ K + + L E K ++LL+ +K DL +
Sbjct: 847 KSAETEKEMATMK------EEFQKIKDELAKSEAKRKELEE---KMVTLLK-EKNDLQLQ 896
Query: 630 LHILQQKYDEVEDKLADI--SQLQSDQVCSEI-KSVHLEEQIDA-LSASKKELALVIENL 685
+ + + E++ + +++Q + E+ + EE+I+A L+A K++L L
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK--ISELLAKINHE- 742
K D + L T+ +E +K NK++N +E L + + K++ EK + E + +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 743 --EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E+ K+ T K++++ ++++E L + K LE + +E L+ +
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQ---VDDLEGSLEQEKKLRMDLERAKRKLEG---DLKLAQE 1070
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQI 857
+ EKQ+ + +E E+ N + + D + ++K++ E++ +EL+++ +
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 858 LLEENQNLQISLSDMQQHYNAL---VEKANRTDLAESE-STKYQTQLRDLESNLKRITHE 913
+ SD+ + + +E+A A+ E + K + + + + +L+ T +
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDK-KVLNEKYE---------KNIEYVTQLEAQ 963
H+ +K+ D E QI++ R K K+ EK E N+E V++ +
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN 1250
Query: 964 LQEYKNNIENLNMNVEELNKMNLELI-DKHVQ--KQQTQSPDYTEQYINEINKLNALLKQ 1020
L++ +E+ ++ + LI D Q + QT+S +++ Q + ++ L +
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRG 1310
Query: 1021 KD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ-RVSKQLLDSKQ 1076
K ++I L +++ + ++ +S E EEE + + Q SK
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370
Query: 1077 HNEELQILVREQDDQI---KELKETKLTFEMNIPKTEGMIISSTIEPMSDD------ANN 1127
+ E Q + + D I +EL+E K + E + + + S + N
Sbjct: 1371 NTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V+ ++++ ++ +L E K E + +L TEL
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRNFDK-ILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+E ++Q LE L EN NL +++L I+ +R E+ ++ KQ + Q +
Sbjct: 1490 IKNAYEESLDQ----LETLKRENKNLQQEISDLTEQIAEG-GKRIHELEKIKKQ-VEQEK 1543
Query: 1248 ADFQ--------KTEHE----LRVQLSAFESKYE---QLLDSVQSSTQEETNKIVTMEQV 1292
+ Q EHE LR+QL + K E ++ + + Q + N I +E +
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603
Query: 1293 TS-LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
S L +++ + + +R L++K +N++EI +
Sbjct: 1604 QSTLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLE 1410
L +S + ++EQ L + E A L ++ R AE ++L+ + +++
Sbjct: 1663 LDDALRSQEDLKEQ--LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 1411 L---KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
L +++ + + ++Q E E++ Q+ E++ + + L+ K
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK-KEQ 1779
Query: 1468 ENANHYETMQK--ESEIERVKL----IEELNVK--ITESVSLNKQVAELNKALEEEVAKT 1519
+ + H E M+K E ++ ++L E+L +K + L +V EL +E E +
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 1520 NEMQTALENQE--IEIVTLNDE-----ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
E L E ++ +T E I LQ++V +K++ + A + ++ + L
Sbjct: 1840 AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 1573 D--NTMNKELLDAVPRAEL 1589
+ EL +A RA++
Sbjct: 1900 AKFRKLQHELEEAEERADI 1918
Score = 99.1 bits (236), Expect = 1e-19
Identities = 196/998 (19%), Positives = 426/998 (42%), Gaps = 76/998 (7%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ ++++L +A LE E SLE
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++SI EK +++EK + ++ L KIE
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLK----LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE 1101
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q+++ KEL+ ++ + E +A ++ S + K + + +++ +L
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1156
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
E T +I N+ K E Q + +DL +E + + T +
Sbjct: 1157 --EEAGGATSAQIEMNK--KREAEFQKMRRDL--EEATLQHEATAATLRKKHADS----V 1206
Query: 450 AQL--QLEHQQHMEGPSLIHVGTNTEDVNEIA-KVQEQLKQELNDEIKDVNVKDLIEKLK 506
A+L Q+++ Q ++ +++++A V+ K + N E ++D + +LK
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
S EE+ +L +++ A + +L + + + S+ + T+++
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA------FTQQIEE 1320
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAISLLESQ--K 623
L +++ E E + N H + S R + D+ ++ E E ++ L +A+S ++ +
Sbjct: 1321 LKRQLEE-EIKAKNALAHAL--QSSRH-DCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 624 FDLVQELHILQ--QKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ E +Q ++ +E + KLA Q + V K LE+ L ++L L
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 681 VIENLK-----LDKEQ--LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM--SAEK 731
+E LDK+Q + + + E+ +L+ +E L +L K+ + E+
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR 791
+ L + E ++ Q + +I E I +E + + C L+ A +E+
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ---AALEEA 1553
Query: 792 RYSLERKADQLGSYLQEKQKAYSEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
SLE + ++ E + SE ++DE +++L +H R+VE ++ E
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHIRIVESMQSTLDAEI 1611
Query: 849 KELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
+ + + I L++ ++ ++Q H N + +A R + ++ TQ+ ++
Sbjct: 1612 R--SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALR-NYRNTQGILKDTQIHLDDALR 1668
Query: 908 KRITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
+ + Q +V+++ + EI E +E R +K+ ++ E V L Q
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
N + L ++++M E+ D + ++ + + ++ I + + LK++ +
Sbjct: 1729 LINTKKKLE---TDISQMQGEMED--ILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 1027 ALNQKINNAQ--VSYMSMVSDYESKLAQFTTK--LENMEEEMQRVSKQLLDSKQHNEELQ 1082
L + N + V + + D +LA K ++ +E ++ + ++ ++ N E
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
+R+ + ++KEL NI + + ++ + S +
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR 1903
Query: 1143 KVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLE 1179
K+Q E E +ER+ + + Q KL + +E +TK+I E
Sbjct: 1904 KLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 95.9 bits (228), Expect = 1e-18
Identities = 149/764 (19%), Positives = 315/764 (41%), Gaps = 48/764 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + + ++ +L + E + KEL++K LL+E +LQ+ +Q
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAE 902
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
L + R D + + +++++ + E + KK+++ED E I+
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDID 961
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 995 KQQ--TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T++ EQ ++++ K+ ++ +K+ + D E++ Q
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KL+ E E+ + ++ D + +LQ ++E +I+EL+E + K E
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 1113 --IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ + + E EF + R L+E A L E
Sbjct: 1142 RSDLSRELEEISERLEE----AGGATSAQIEMNKKREAEFQKMRRDLEE--ATLQHEATA 1195
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS---TVAELRSSISS 1226
+ +++ EL G + N +++ Q L+ + ++ E D+L S TV++ + ++
Sbjct: 1196 ATLRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK 1253
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
+++EL + Q+ T R+Q + E QL + +Q K
Sbjct: 1254 MCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFS-RQLDEKEALVSQLSRGKQ 1312
Query: 1287 VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
+Q+ L+ +L+++ + L + ++LR + E+E+
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQ--------ESKAELQ 1364
Query: 1347 XXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
TE ++ E + EE + KK VN A+ LE T
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN-AKCASLEKT 1423
Query: 1407 HQL---ELKDSEI-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES---EL 1459
Q E++D + ++T+ L ++ F+ + L E++++ E+ E E+ E
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI---LAEWKQKCEETHAELEASQKEA 1480
Query: 1460 AILRLKMHENANHYETMQKESEI---ERVKLIEELNVKITESVSL-NKQVAELNKALEEE 1515
L ++ + N YE + E E L +E++ +TE ++ K++ EL K ++
Sbjct: 1481 RSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS-DLTEQIAEGGKRIHELEKIKKQV 1539
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Score = 92.3 bits (219), Expect = 1e-17
Identities = 203/1122 (18%), Positives = 444/1122 (39%), Gaps = 81/1122 (7%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 909 ERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
A + E A + K L +G + + + E Q D ++
Sbjct: 968 AKVEKEKHATENKVKN---LTEEMAGLDETIAKLTKEKKALQEAHQQTLD------DLQA 1018
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
E + +L K + E + D D A+ +LE + S++ +
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVD--DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE 1076
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ ++E K +E L +I+D L +K+K + +I +L +EI+A +
Sbjct: 1077 NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
K + +++++ + + + + + ++ QK+ + E+ LQ H
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR-DLEEATLQ-HEAT 1194
Query: 588 YDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ R +D ++ E ++NL + K LE +K ++ E+ L + V +
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQK----LEKEKSEMKMEIDDLASNVETVSKAKGN 1250
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLENDK 703
+ +++C LE+Q+ L + ++E +I +L + +L G ++K
Sbjct: 1251 L-----EKMCRT-----LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
E ++++L + ++ ++I EL ++ E ++K + + + DL
Sbjct: 1301 EALVSQL-----------SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 764 IENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E E E + K+ + R L ++ + R E A Q L+E +K +
Sbjct: 1350 REQYEEE-QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK----------K 1398
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-NQILLE-ENQNLQISLSDMQQHY--NA 878
L RL +H V + +E + LQ + ++L+ E N + D +Q
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQ 935
L E + + +E Q + R L + L +I + ++ + Q K+E ++L+ E +
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 936 IESAIRDKKVLN--EKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
E K ++ EK +K +E +L+A L+E + ++E+ + + ++ L +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI-QLELNQVKSE 1577
Query: 993 VQKQQTQSPDYTEQY-INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
V ++ + + +Q N I + ++ D EI + N I + +++ E +L
Sbjct: 1578 VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLN 1636
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
+ L D++ H L +R Q+D ++L + N+ + E
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIH---LDDALRSQEDLKEQL--AMVERRANLLQAEI 1691
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ +T+E ++ + + L + I + L+ +++ E+++
Sbjct: 1692 EELRATLE-QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ E + + E++ + + L N+ TV +L+ + A +Q
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA-EQL 1809
Query: 1232 GFEIAELWKQHLAQREADFQ-KTEHELRVQLSAFES--KYEQLLDSVQSSTQEETNKIVT 1288
+ + Q L R + + + E E + A + K+E+ + + T+E+ I+
Sbjct: 1810 ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILR 1869
Query: 1289 MEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
++ V LQ K++ + +E+ + + L+ E+E+
Sbjct: 1870 LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Score = 77.4 bits (182), Expect = 4e-13
Identities = 186/902 (20%), Positives = 371/902 (41%), Gaps = 94/902 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
L +K+K+ +S LQ K++ + + LQ+KI E IE +
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 207 XXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFE 266
+ ++ +++E A A+ + K+R + E + +R LEEA EA
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMR-RDLEEATLQHEATAAT 1197
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIE-PSCEEKTEIEEKGS-LEIANMTE- 323
+ +H+ EL + KQ +E E K EI++ S +E + +
Sbjct: 1198 LRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 324 -LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR-NTASK 381
L K LE +++ +E + + + + + + S + S + K + S+
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
K ++Q E Q ++ KN +A + + DL+ ++Y E+
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAH-ALQSSRHDCDLLREQY--EEEQESKAELQRA 1366
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK-D 500
+T +AQ + +++ TE++ E K Q Q + ++ VN K
Sbjct: 1367 LSKANTEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418
Query: 501 LIEKLKS-AEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+EK K + ++ L +++ N K ++ K+ + QK + +++ S K
Sbjct: 1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1478
Query: 556 EIVRLTEELHHLSQKVAE-------LEEEKGNLQLHLVDY-----DSGRMI-ESDVYKKM 602
E L EL + E L+ E NLQ + D + G+ I E + KK
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538
Query: 603 IEME--NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA----DISQLQSD--Q 654
+E E L +A + LE ++ +++ L Q EV+ K+A +I QL+ + +
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 655 VCSEIKS---VHLEEQIDALSASKK------ELALVIENL-KLDKEQL------YGTIKD 698
+ ++S + + DA+ KK E+ + + + ++ E L G +KD
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKD 1658
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KIQTQFGIDAKI 757
+ +D + + Q ++E + + ++ + +I EL A + E+S KI Q +DA
Sbjct: 1659 TQIHLDDAL-RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
+ + L+ +N +K K LE I+ M+ + ++A ++ +KA ++
Sbjct: 1718 RVQLLHTQNTSLINTKKK-----LETDISQMQGEMEDILQEARNAE---EKAKKAITDAA 1769
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ-QHY 876
+ +EL D +E+ +E K+L Q+ L+E + L + Q Q
Sbjct: 1770 MMAEELKKE----QDTSAHLERMKKNMEQTVKDL----QLRLDEAEQLALKGGKKQIQKL 1821
Query: 877 NALV-EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK-KEIEDLEIEFNT 934
A V E + + + + LR E +K +T +QT +K ++DL +
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT--YQTEEDRKNILRLQDLVDKLQA 1879
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+++S R + E+ N+ +L+ +L+E + + V +L + E+ K +
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Query: 995 KQ 996
++
Sbjct: 1940 EE 1941
>AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa
protein.
Length = 1941
Score = 116 bits (279), Expect = 7e-25
Identities = 211/1093 (19%), Positives = 437/1093 (39%), Gaps = 84/1093 (7%)
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
K+M + F K+ D E+ + + L +K+ L +EK +LQL + G +
Sbjct: 853 KEMATMKEEFQKIKD---ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVC 656
++I+ + E ++K ++ + ++ EL ++K DE + DI L+
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL----YGTIKDL--ENDKEDIMNKL 710
E + E ++ L+ L I L +K+ L T+ DL E DK + + K
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 711 QNYIQENM-DLTDKLE-----KMSAEKISELL---AKINHEEQSKIQTQ-FGIDAKIQER 760
+ +++ + DL LE +M E+ L K+ E I+ + +D K++++
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQE 820
+ I N++S++ ++ +L++ I ++ R LE + + + + +K S+ + +
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM-QQHYNAL 879
+E+ RL + Q+ + E QK + L E + + + + ++H +++
Sbjct: 1150 EEISERLE---EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 880 VEKANRTD-------LAESESTKYQTQLRDLESNLKRI------------THEHQTLIVQ 920
E + D E E ++ + ++ DL SN++ + T E Q ++
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 921 KKKEIEDLEIEFNTQIESAIR-DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
K+E + I T ++ + + + ++ V+QL Q + IE L +E
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN---KLNALLKQKDEEIIALNQKINNAQ 1036
E K L +Q + EQY E +L L + + E+ K
Sbjct: 1327 EEIKAKNALAHA-LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ----HNEELQILVREQDDQI 1092
+ + + + KLAQ E E + L +KQ E+L + V +
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 1093 KELKETKLTFEMNIP--KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
L + + F+ + K + + +E +A ++ + + E
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE-SLDQLETL 1504
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEN 1210
+E LQ++ + L ++ E +I +LE + ++ Q + + ++ LE +
Sbjct: 1505 KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKI 1564
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
+ + +++S + + ++ EI +L + H+ E+ + E+R + A K +
Sbjct: 1565 LRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Query: 1271 LLDSVQSSTQ-EETNKIV--TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQI 1320
D + Q N++ + + Q L+D + HL +L+E+ A V +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
+L++EIE+ + L T+N S +++ +I++
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRND 1432
+++ + DA EL + + E +K E T+ L R D
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1804
Query: 1433 EFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEI 1482
E E + ++Q+ + E R+ +L E ESE A+ L+ HE T Q E +
Sbjct: 1805 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1864
Query: 1483 ERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT 1541
+ + +++L K+ V S +Q E + +AK ++Q LE E ++
Sbjct: 1865 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Query: 1542 NLQNMVRASSSKI 1554
L+ R +K+
Sbjct: 1925 KLRVKSREVHTKV 1937
Score = 106 bits (254), Expect = 8e-22
Identities = 220/1099 (20%), Positives = 466/1099 (42%), Gaps = 106/1099 (9%)
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K AE E+E ++ + + I+ ++ K + + L E K ++LL+ +K DL +
Sbjct: 847 KSAETEKEMATMK------EEFQKIKDELAKSEAKRKELEE---KMVTLLK-EKNDLQLQ 896
Query: 630 LHILQQKYDEVEDKLADI--SQLQSDQVCSEI-KSVHLEEQIDA-LSASKKELALVIENL 685
+ + + E++ + +++Q + E+ + EE+I+A L+A K++L L
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK--ISELLAKINHE- 742
K D + L T+ +E +K NK++N +E L + + K++ EK + E + +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 743 --EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E+ K+ T K++++ ++++E L + K LE + +E L+ +
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQ---VDDLEGSLEQEKKLRMDLERAKRKLEG---DLKLAQE 1070
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQI 857
+ EKQ+ + +E E+ N + + D + ++K++ E++ +EL+++ +
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 858 LLEENQNLQISLSDMQQHYNAL---VEKANRTDLAESE-STKYQTQLRDLESNLKRITHE 913
+ SD+ + + +E+A A+ E + K + + + + +L+ T +
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDK-KVLNEKYE---------KNIEYVTQLEAQ 963
H+ +K+ D E QI++ R K K+ EK E N+E V++ +
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN 1250
Query: 964 LQEYKNNIENLNMNVEELNKMNLELI-DKHVQ--KQQTQSPDYTEQYINEINKLNALLKQ 1020
L++ +E+ ++ + LI D Q + QT+S +++ Q + ++ L +
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRG 1310
Query: 1021 KD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ-RVSKQLLDSKQ 1076
K ++I L +++ + ++ +S E EEE + + Q SK
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370
Query: 1077 HNEELQILVREQDDQI---KELKETKLTFEMNIPKTEGMIISSTIEPMSDD------ANN 1127
+ E Q + + D I +EL+E K + E + + + S + N
Sbjct: 1371 NTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V+ ++++ ++ +L E K E + +L TEL
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRNFDK-ILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+E ++Q LE L EN NL +++L I+ +R E+ ++ KQ + Q +
Sbjct: 1490 IKNAYEESLDQ----LETLKRENKNLQQEISDLTEQIAEG-GKRIHELEKIKKQ-VEQEK 1543
Query: 1248 ADFQ--------KTEHE----LRVQLSAFESKYE---QLLDSVQSSTQEETNKIVTMEQV 1292
+ Q EHE LR+QL + K E ++ + + Q + N I +E +
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603
Query: 1293 TS-LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
S L +++ + + +R L++K +N++EI +
Sbjct: 1604 QSTLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLE 1410
L +S + ++EQ L + E A L ++ R AE ++L+ + +++
Sbjct: 1663 LDDALRSQEDLKEQ--LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 1411 L---KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
L +++ + + ++Q E E++ Q+ E++ + + L+ K
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK-KEQ 1779
Query: 1468 ENANHYETMQK--ESEIERVKL----IEELNVK--ITESVSLNKQVAELNKALEEEVAKT 1519
+ + H E M+K E ++ ++L E+L +K + L +V EL +E E +
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 1520 NEMQTALENQE--IEIVTLNDE-----ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
E L E ++ +T E I LQ++V +K++ + A + ++ + L
Sbjct: 1840 AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 1573 D--NTMNKELLDAVPRAEL 1589
+ EL +A RA++
Sbjct: 1900 AKFRKLQHELEEAEERADI 1918
Score = 99.1 bits (236), Expect = 1e-19
Identities = 196/998 (19%), Positives = 426/998 (42%), Gaps = 76/998 (7%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ ++++L +A LE E SLE
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++SI EK +++EK + ++ L KIE
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLK----LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE 1101
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q+++ KEL+ ++ + E +A ++ S + K + + +++ +L
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1156
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
E T +I N+ K E Q + +DL +E + + T +
Sbjct: 1157 --EEAGGATSAQIEMNK--KREAEFQKMRRDL--EEATLQHEATAATLRKKHADS----V 1206
Query: 450 AQL--QLEHQQHMEGPSLIHVGTNTEDVNEIA-KVQEQLKQELNDEIKDVNVKDLIEKLK 506
A+L Q+++ Q ++ +++++A V+ K + N E ++D + +LK
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 507 SAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
S EE+ +L +++ A + +L + + + S+ + T+++
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA------FTQQIEE 1320
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAISLLESQ--K 623
L +++ E E + N H + S R + D+ ++ E E ++ L +A+S ++ +
Sbjct: 1321 LKRQLEE-EIKAKNALAHAL--QSSRH-DCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 624 FDLVQELHILQ--QKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ E +Q ++ +E + KLA Q + V K LE+ L ++L L
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 681 VIENLK-----LDKEQ--LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM--SAEK 731
+E LDK+Q + + + E+ +L+ +E L +L K+ + E+
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR 791
+ L + E ++ Q + +I E I +E + + C L+ A +E+
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ---AALEEA 1553
Query: 792 RYSLERKADQLGSYLQEKQKAYSEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
SLE + ++ E + SE ++DE +++L +H R+VE ++ E
Sbjct: 1554 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHIRIVESMQSTLDAEI 1611
Query: 849 KELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
+ + + I L++ ++ ++Q H N + +A R + ++ TQ+ ++
Sbjct: 1612 R--SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALR-NYRNTQGILKDTQIHLDDALR 1668
Query: 908 KRITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
+ + Q +V+++ + EI E +E R +K+ ++ E V L Q
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
N + L ++++M E+ D + ++ + + ++ I + + LK++ +
Sbjct: 1729 LINTKKKLE---TDISQMQGEMED--ILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 1027 ALNQKINNAQ--VSYMSMVSDYESKLAQFTTK--LENMEEEMQRVSKQLLDSKQHNEELQ 1082
L + N + V + + D +LA K ++ +E ++ + ++ ++ N E
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
+R+ + ++KEL NI + + ++ + S +
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR 1903
Query: 1143 KVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLE 1179
K+Q E E +ER+ + + Q KL + +E +TK+I E
Sbjct: 1904 KLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 95.9 bits (228), Expect = 1e-18
Identities = 149/764 (19%), Positives = 315/764 (41%), Gaps = 48/764 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + + ++ +L + E + KEL++K LL+E +LQ+ +Q
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAE 902
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
L + R D + + +++++ + E + KK+++ED E I+
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDID 961
Query: 938 S-AIRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 995 KQQ--TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T++ EQ ++++ K+ ++ +K+ + D E++ Q
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KL+ E E+ + ++ D + +LQ ++E +I+EL+E + K E
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 1113 --IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ + + E EF + R L+E A L E
Sbjct: 1142 RSDLSRELEEISERLEE----AGGATSAQIEMNKKREAEFQKMRRDLEE--ATLQHEATA 1195
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS---TVAELRSSISS 1226
+ +++ EL G + N +++ Q L+ + ++ E D+L S TV++ + ++
Sbjct: 1196 ATLRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK 1253
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
+++EL + Q+ T R+Q + E QL + +Q K
Sbjct: 1254 MCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFS-RQLDEKEALVSQLSRGKQ 1312
Query: 1287 VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
+Q+ L+ +L+++ + L + ++LR + E+E+
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQ--------ESKAELQ 1364
Query: 1347 XXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
TE ++ E + EE + KK VN A+ LE T
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN-AKCASLEKT 1423
Query: 1407 HQL---ELKDSEI-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES---EL 1459
Q E++D + ++T+ L ++ F+ + L E++++ E+ E E+ E
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI---LAEWKQKCEETHAELEASQKEA 1480
Query: 1460 AILRLKMHENANHYETMQKESEI---ERVKLIEELNVKITESVSL-NKQVAELNKALEEE 1515
L ++ + N YE + E E L +E++ +TE ++ K++ EL K ++
Sbjct: 1481 RSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS-DLTEQIAEGGKRIHELEKIKKQV 1539
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Score = 92.3 bits (219), Expect = 1e-17
Identities = 203/1122 (18%), Positives = 444/1122 (39%), Gaps = 81/1122 (7%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ + ++ E K LE + E + L +++
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 909 ERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
A + E A + K L +G + + + E Q D ++
Sbjct: 968 AKVEKEKHATENKVKN---LTEEMAGLDETIAKLTKEKKALQEAHQQTLD------DLQA 1018
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
E + +L K + E + D D A+ +LE + S++ +
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVD--DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE 1076
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ ++E K +E L +I+D L +K+K + +I +L +EI+A +
Sbjct: 1077 NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
K + +++++ + + + + + ++ QK+ + E+ LQ H
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR-DLEEATLQ-HEAT 1194
Query: 588 YDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ R +D ++ E ++NL + K LE +K ++ E+ L + V +
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQK----LEKEKSEMKMEIDDLASNVETVSKAKGN 1250
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLENDK 703
+ +++C LE+Q+ L + ++E +I +L + +L G ++K
Sbjct: 1251 L-----EKMCRT-----LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
E ++++L + ++ ++I EL ++ E ++K + + + DL
Sbjct: 1301 EALVSQL-----------SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 764 IENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E E E + K+ + R L ++ + R E A Q L+E +K +
Sbjct: 1350 REQYEEE-QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK----------K 1398
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-NQILLE-ENQNLQISLSDMQQHY--NA 878
L RL +H V + +E + LQ + ++L+ E N + D +Q
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI 1458
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQ 935
L E + + +E Q + R L + L +I + ++ + Q K+E ++L+ E +
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 936 IESAIRDKKVLN--EKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
E K ++ EK +K +E +L+A L+E + ++E+ + + ++ L +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI-QLELNQVKSE 1577
Query: 993 VQKQQTQSPDYTEQY-INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
V ++ + + +Q N I + ++ D EI + N I + +++ E +L
Sbjct: 1578 VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLN 1636
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
+ L D++ H L +R Q+D ++L + N+ + E
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIH---LDDALRSQEDLKEQL--AMVERRANLLQAEI 1691
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ +T+E ++ + + L + I + L+ +++ E+++
Sbjct: 1692 EELRATLE-QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ E + + E++ + + L N+ TV +L+ + A +Q
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA-EQL 1809
Query: 1232 GFEIAELWKQHLAQREADFQ-KTEHELRVQLSAFES--KYEQLLDSVQSSTQEETNKIVT 1288
+ + Q L R + + + E E + A + K+E+ + + T+E+ I+
Sbjct: 1810 ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILR 1869
Query: 1289 MEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
++ V LQ K++ + +E+ + + L+ E+E+
Sbjct: 1870 LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Score = 77.4 bits (182), Expect = 4e-13
Identities = 186/902 (20%), Positives = 371/902 (41%), Gaps = 94/902 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
L +K+K+ +S LQ K++ + + LQ+KI E IE +
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 207 XXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFE 266
+ ++ +++E A A+ + K+R + E + +R LEEA EA
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMR-RDLEEATLQHEATAAT 1197
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIE-PSCEEKTEIEEKGS-LEIANMTE- 323
+ +H+ EL + KQ +E E K EI++ S +E + +
Sbjct: 1198 LRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 324 -LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR-NTASK 381
L K LE +++ +E + + + + + + S + S + K + S+
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 382 MKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
K ++Q E Q ++ KN +A + + DL+ ++Y E+
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAH-ALQSSRHDCDLLREQY--EEEQESKAELQRA 1366
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK-D 500
+T +AQ + +++ TE++ E K Q Q + ++ VN K
Sbjct: 1367 LSKANTEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418
Query: 501 LIEKLKS-AEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+EK K + ++ L +++ N K ++ K+ + QK + +++ S K
Sbjct: 1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1478
Query: 556 EIVRLTEELHHLSQKVAE-------LEEEKGNLQLHLVDY-----DSGRMI-ESDVYKKM 602
E L EL + E L+ E NLQ + D + G+ I E + KK
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538
Query: 603 IEME--NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA----DISQLQSD--Q 654
+E E L +A + LE ++ +++ L Q EV+ K+A +I QL+ + +
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598
Query: 655 VCSEIKS---VHLEEQIDALSASKK------ELALVIENL-KLDKEQL------YGTIKD 698
+ ++S + + DA+ KK E+ + + + ++ E L G +KD
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKD 1658
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KIQTQFGIDAKI 757
+ +D + + Q ++E + + ++ + +I EL A + E+S KI Q +DA
Sbjct: 1659 TQIHLDDAL-RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
+ + L+ +N +K K LE I+ M+ + ++A ++ +KA ++
Sbjct: 1718 RVQLLHTQNTSLINTKKK-----LETDISQMQGEMEDILQEARNAE---EKAKKAITDAA 1769
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ-QHY 876
+ +EL D +E+ +E K+L Q+ L+E + L + Q Q
Sbjct: 1770 MMAEELKKE----QDTSAHLERMKKNMEQTVKDL----QLRLDEAEQLALKGGKKQIQKL 1821
Query: 877 NALV-EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK-KEIEDLEIEFNT 934
A V E + + + + LR E +K +T +QT +K ++DL +
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT--YQTEEDRKNILRLQDLVDKLQA 1879
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+++S R + E+ N+ +L+ +L+E + + V +L + E+ K +
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Query: 995 KQ 996
++
Sbjct: 1940 EE 1941
>AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein.
Length = 1978
Score = 116 bits (279), Expect = 7e-25
Identities = 229/1060 (21%), Positives = 459/1060 (43%), Gaps = 116/1060 (10%)
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
+I+ +E++ LS +V+ LE E G+ + H+ + ++ ++ +++N+ +K
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWR-HIAQTSKAQGTDNSDQSEICKLQNI----IKE 220
Query: 616 ISLLESQKFDLVQ-ELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
+ SQ+ D Q E+ +LQ + + KL +IS+ +++ EE+I+ L
Sbjct: 221 LKQNRSQEIDDHQHEMSVLQNAHQQ---KLTEISRRHREELSD------YEERIEELENL 271
Query: 675 KKELALVIENLKLDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
++ + L K ++ TI+ L+ +K + K++ + D+ KL SAE
Sbjct: 272 LQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLS--SAENDR 329
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++L + +EQ ++ + +I E EN++ E SK L+ S D
Sbjct: 330 DILRR--EQEQLNVEKR-----QIMEE---CENLKLECSK-------LQPSAVKQSDTMT 372
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
ER Q GS ++E + + E+E++ RL+ L + D + + L+++ + L+K
Sbjct: 373 EKERILAQSGS-VEEVFRLRQALSDAENEIM-RLSSL-NQDNSLAEDNLKLKMRIEVLEK 429
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ +L +E + LQ+SL + Y + A R +SE + L E L + E
Sbjct: 430 EKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE 489
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+TLI EIE+L+ + + I K L+++ + +++L+ L + K +
Sbjct: 490 KETLIA----EIEELDRQNQEATKHMILIKAQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L + ++ K EL + V Q +E +N+++ L+ K E ++ ++N
Sbjct: 546 LEDDKMDITK---ELDVQFVLLIQ------SEVALNDLHLTKQKLEDKVENLV---DQLN 593
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS--KQHNEELQ-ILVREQDD 1090
+Q S +S+ + + + + EEE+ R+ +L+ S + N + L++E++
Sbjct: 594 KSQESNVSI----QKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LK+ E + + +E D ++ E+
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT 709
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNT-ELTGHDVVNQEQINQLKSKLEQLNTE 1209
I E L+ + ++ EL C+ K LE N E T ++ N +N L E
Sbjct: 710 IVE--TLKMEKGEIEAEL--CWAKKRLLEEANKYEKTIEELSNARNLN-----TSALQLE 760
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH------ELRVQLSA 1263
+++L+ ++ EIAEL K+++ Q + D ++T+ E + QL+
Sbjct: 761 HEHLI-----------KLNQKKDMEIAEL-KKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 808
Query: 1264 FESKYEQLLDSVQ---SSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+K E ++ ++ S QEE +K + + L+ +++K+ L +++E+ + +
Sbjct: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRT--ENQSYKQMQEQSIL-NINEENAQ 1376
+E LR E L T E+ + Q I+ + N+ Q
Sbjct: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI--YQKTHEYTIT-LTQRNDE 1433
L +S + A +L LE KD EI QKT E T L + +
Sbjct: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLF--LE-KDEEIKSLQKTIEQIKTQLHEERQD 985
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
+ + + E +++ L E SE L E + + KE E+E +KL+ E N+
Sbjct: 986 IQTDNSDIFQ-ETKVQSLNIENGSEKH--DLSKAETERLVKGI-KERELE-IKLLNEKNI 1040
Query: 1494 KITESV-SLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASS 1551
+T+ + L+K +V +L + +++ K E+Q + I + ++ LQ ++A +
Sbjct: 1041 SLTKQIDQLSKDEVGKLTQIIQQ---KDLEIQAL--HARISSTSHTQDVVYLQQQLQAYA 1095
Query: 1552 SKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDL 1591
+ +K FA ++ R+ T +++D V E L
Sbjct: 1096 MEREK--VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL 1133
Score = 111 bits (268), Expect = 2e-23
Identities = 239/1121 (21%), Positives = 474/1121 (42%), Gaps = 118/1121 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ---EQLKQELNDEIKDVNVKDLI------- 502
++ H +H+ S GT+ D +EI K+Q ++LKQ + EI D + +
Sbjct: 187 EVGHWRHIAQTSKAQ-GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQ 245
Query: 503 ----------EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID--NFSKV 550
E+L EE+I +L + + +I+ + K+ +MQKTI KV
Sbjct: 246 KLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLS---KIYEMQKTIQVLQIEKV 302
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENLA 609
+S K++ +L +++ +++K++ E ++ L+ + R I + +E L
Sbjct: 303 -ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQ 361
Query: 610 ETRLK-AISLLESQKF----DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
+ +K + ++ E ++ V+E+ L+Q + E+++ +S L D +E ++ L
Sbjct: 362 PSAVKQSDTMTEKERILAQSGSVEEVFRLRQALSDAENEIMRLSSLNQDNSLAE-DNLKL 420
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+ +I+ L +KE +L L +KE+L ++ L N+ E I + I + +L D
Sbjct: 421 KMRIEVL---EKEKSL----LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEES 784
+ A K EL I+ E+++ I +D + QE ++ I+++LSK ++ E
Sbjct: 474 LNLEA-KEQELNQSIS-EKETLIAEIEELDRQNQEATKHMILIKAQLSKQQN------EG 525
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+++ + L + ++ +K E +Q L+ L +D + KQ LE
Sbjct: 526 DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQFVLLIQSEVAL--NDLHLTKQKLED 583
Query: 845 EHENKELQ-KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL 903
+ EN Q K+Q E N ++Q ++++H + N +L+ + Q+ +D
Sbjct: 584 KVENLVDQLNKSQ---ESNVSIQKENLELKEHI-----RQNEEELSRIRNELMQSLNQDS 635
Query: 904 ESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT-QLE 961
SN K + E + + K+ + +LE + N ++ D K+ NEK E V QLE
Sbjct: 636 NSNFKDTLLKEREAEVRNLKQNLSELE-QLNENLKKVAFDVKMENEKLVLACEDVRHQLE 694
Query: 962 A------QLQEYKNNI-ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
QL KN I E L M E+ + L K + ++ + E+ N N
Sbjct: 695 ECLAGNNQLSLEKNTIVETLKMEKGEI-EAELCWAKKRLLEEANKYEKTIEELSNARNLN 753
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
+ L+ + E +I LNQK D E +A+ +E M+ + + L S
Sbjct: 754 TSALQLEHEHLIKLNQK------------KDME--IAELKKNIEQMDTDHKETKDVLSSS 799
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ ++L L+ +++ I++LKE + + K + + I + D
Sbjct: 800 LEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLGS 857
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT--ELQECYTKIIQLET----LNTELTGH 1188
L QEE E ++E A T + E +++ QL T L E+ H
Sbjct: 858 MKEENNHL--QEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHH 915
Query: 1189 DVVNQEQIN---QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ ++Q QL L++ E D ++ ++ + ++ EI L K + Q
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKT-IEQ 974
Query: 1246 READFQKTEHELRVQLS-AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ + +++ S F+ Q L+ S + + +K T V ++++E
Sbjct: 975 IKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKG----IKEREL 1030
Query: 1305 HLRNLQEKYADVINQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ 1363
++ L EK + QI+ L + E+ T++ Y Q Q
Sbjct: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
Query: 1364 EQSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
Q+ E+ A L + + ++ AK L ++L+D T
Sbjct: 1091 LQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL---IKLQDENKKLSTRF 1147
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKM--HE----NANHYETM 1476
+ + +N+ + + E + I+ L+ + ++ LA+L+ +E N+N +E +
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEEL 1207
Query: 1477 QKESE--IERVKLIEELNVKITESV-SLNKQVAELNKALEE 1514
+E + ++VK +EE ++ +V ++ + A+L + L +
Sbjct: 1208 LQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248
Score = 109 bits (263), Expect = 6e-23
Identities = 267/1300 (20%), Positives = 518/1300 (39%), Gaps = 144/1300 (11%)
Query: 308 TEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS 367
+ + + SL N+ +L +IE+LE + Q +EL+ L + E + + S
Sbjct: 405 SSLNQDNSLAEDNL-KLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKS------ 457
Query: 368 PLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYV 427
TA++ S S+L LN LE Q LN+ + +KE +
Sbjct: 458 ----------TATRDISLDSELHDLRLN--------------LEAKEQELNQSISEKETL 493
Query: 428 ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ 487
I+E + K ++ + QL QQ+ EG S+I +LKQ
Sbjct: 494 IAEIEELDRQNQEAT--KHMILIKAQLSKQQN-EGDSII----------------SKLKQ 534
Query: 488 ELNDEIKDVN--VKDLIEKLKSAEEQ-ITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI 544
+LNDE K V+ D ++ K + Q + + E+ + ++ K K K ++ +
Sbjct: 535 DLNDEKKRVHQLEDDKMDITKELDVQFVLLIQSEVALNDLHLTKQKLEDK-----VENLV 589
Query: 545 DNFSKVSDSNKEIVRLTEEL-HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
D +K +SN I + EL H+ Q EL + L L + ++ + ++
Sbjct: 590 DQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
Query: 604 EMENLAETRLKAISLLESQK---FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E+ NL + + L E+ K FD+ E L ++V +L + L + S K
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEEC--LAGNNQLSLEK 707
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ +E + EL + L + + TI++L N + + LQ + + L
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Query: 721 TDKLEKMSAE-KISELLAKINHEE-----QSKIQTQFGIDAKIQERDLYIENIESELSKY 774
K + AE K + +H+E S ++ Q + I +++++IE ++ SK
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
Query: 775 KSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH- 833
+ + + +++ E R ++E K LGS +E E +E +R A + D
Sbjct: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREE-QSRTAPVADPK 886
Query: 834 --DRVVE-----KQLLEI-EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
D V E QL I EH +E++ +I+ ++NQ+ L +Q+ + E R
Sbjct: 887 TLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE--FR 944
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
+ +T Q L + + +K + Q I Q K ++ + + T ++ KV
Sbjct: 945 YQHEQMNATHTQLFL-EKDEEIKSL----QKTIEQIKTQLHEERQDIQTDNSDIFQETKV 999
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+ E E +A+ + I+ + ++ LN+ N+ L T+ D
Sbjct: 1000 QSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISL---------TKQIDQLS 1050
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
+ +E+ KL +++QKD EI AL+ +I++ S+ V + +L + + E + +
Sbjct: 1051 K--DEVGKLTQIIQQKDLEIQALHARISS--TSHTQDVVYLQQQLQAYAMEREKVFAVLN 1106
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS--- 1122
+++ K ++ +V ++ + +L++ + + TI+ +S
Sbjct: 1107 EKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRII 1166
Query: 1123 -DDANNVDXXXXXXXXXXXXLKV------------QEEEEFIQERSVLQEQSAKLNTELQ 1169
+ +D L+ + EE +QER L++Q K+ Q
Sbjct: 1167 REKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQ 1226
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ T + ++ + +L QE+++QL++ Q+ ++DN + I S +
Sbjct: 1227 QVMTTVQNMQHESAQL-------QEELHQLQA---QVLVDSDNNSKLQVDYTGLIQS-YE 1275
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM 1289
Q ++ + Q LAQ + + + + L + QL + + Q +
Sbjct: 1276 QNETKLKN-FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASK 1334
Query: 1290 EQVTSLQNKL--QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
+V S ++L Q+ EE ++LQEK A I ++ + D A
Sbjct: 1335 SEVLSESSELLQQELEELRKSLQEKDA-TIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L+ + +++ ++ L I ++ QL SS + A + E
Sbjct: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQL-LSSNENFTNKVNENELLRQAVTNLKERIL 1452
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
LE+ ++ K I T R E E Q L E + + EKE E M
Sbjct: 1453 ILEMDIGKL--KGENEKIVETYRGKETE--YQALQETNMKFSMMLREKEFECH----SMK 1504
Query: 1468 ENANHYETMQKESEI----ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQ 1523
E A +E + KE E E +L+ + ++V ++ ++ AL+++ + +Q
Sbjct: 1505 EKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQ 1564
Query: 1524 TALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
++ + N E+ L+N + S + A D
Sbjct: 1565 NEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED 1604
Score = 102 bits (244), Expect = 1e-20
Identities = 226/1137 (19%), Positives = 455/1137 (40%), Gaps = 84/1137 (7%)
Query: 236 KQRLLKDIESK----DVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXX 291
K LLK+ E++ +S LE+ N+ L+ F++ +E+ KL E
Sbjct: 640 KDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 699
Query: 292 XXXLAKQS---IEPSCEEKTEIE------EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
L+ + +E EK EIE +K LE AN E T + EL N
Sbjct: 700 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE-ELSNARNLNTSALQ 758
Query: 343 KELENKLATMGTESKAVSSPSKKGSPL-ISRKSGRNTASKMKSPWSQLSSETLNQDTDKK 401
E E+ + + ++ K + K ++ S QL+ ++ +
Sbjct: 759 LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIE 818
Query: 402 INKNEIAKLEMVIQSLNKDLVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
K +KL+ + ++ L E + I EKD + +L+ E +
Sbjct: 819 KLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSR 878
Query: 459 H---MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDE---IKDVNVK--DLIEKLKSAEE 510
+ +L V +V+++ ++E L++E+ I+D N L++ L+ ++
Sbjct: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK 938
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK 570
++ + + + N ++ ++K +QKTI+ ++ ++ K
Sbjct: 939 EMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETK 998
Query: 571 VAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL 630
V L E G+ + L ++ R+++ + ++ +E++ L E + ++ D V +L
Sbjct: 999 VQSLNIENGSEKHDLSKAETERLVKG-IKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 1057
Query: 631 -HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
I+QQK E++ A IS Q V+L++Q+ A + ++++ V+ +
Sbjct: 1058 TQIIQQKDLEIQALHARISSTSHTQ-----DVVYLQQQLQAYAMEREKVFAVLNEKTREN 1112
Query: 690 EQL---YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
L Y + D+ KE + KLQ+ EN L+ + E + E + ++ + K
Sbjct: 1113 SHLKTEYHKMMDIVAAKEAALIKLQD---ENKKLSTRFESSGQDMFRETIQNLSRIIREK 1169
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
IDA Q+ + +++ + ++ + ++++R L+++ ++ +
Sbjct: 1170 ---DIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERD-KLKQQVKKMEEWK 1225
Query: 807 QE-----KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQL----LEIEHENKELQKKNQI 857
Q+ + + +QE+ + VL+D D + Q+ L +E E + KN
Sbjct: 1226 QQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKN-- 1283
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQT 916
+E +Q S+ + + L+ K + S ++ Q + L ++ + E
Sbjct: 1284 FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSE 1343
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN-IENLN 975
L+ Q E+E+L + ++ IR + N + +I ++LE + E ++ I+ L
Sbjct: 1344 LLQQ---ELEELRKSLQEK-DATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK----DEEIIALNQK 1031
+ L K+ L+ D ++ + Q E + N++N+ N LL+Q E I+ L
Sbjct: 1400 EKQDVLQKL-LKEKDLLIKAKSDQLLSSNENFTNKVNE-NELLRQAVTNLKERILILEMD 1457
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLE-NMEEEMQRVSKQLLDSKQHNEEL---QILVRE 1087
I + +V Y K ++ E NM+ M K+ + L Q+L +
Sbjct: 1458 IGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK 1517
Query: 1088 QDDQIKELKETKLTFEMNIPKT-------EGMIISSTIEPMSDDA--NNVDXXXXXXXXX 1138
+ + EL + + KT + ++++ + M + A N V
Sbjct: 1518 EQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRS 1577
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
L+ E S +E A + E + + E L + + + + Q
Sbjct: 1578 NQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQ 1637
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQREADFQKTEHE 1256
++S EQLN + T LR +S V Q +A L +H Q E E E
Sbjct: 1638 VESLQEQLNVVSKQRDETA--LRFCLSGTVKQYRLSLANLQMVLEHFQQEEKAMYSAELE 1695
Query: 1257 LRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEK 1312
+ QL A K + L+ S QE ++ ++ + L +L KEE + L+ +
Sbjct: 1696 KQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ 1752
Score = 96.3 bits (229), Expect = 8e-19
Identities = 218/1094 (19%), Positives = 457/1094 (41%), Gaps = 95/1094 (8%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
++T + KM++ I E W K+RLL++ + I L A L +A ++ EH
Sbjct: 707 KNTIVETLKMEKGEIEAELCWA--KKRLLEEANKYEKTIEELSNARNLNTSA-LQLEHEH 763
Query: 272 S-KLAQELEQXXXXXXXXXXXXXXLAKQS---IEPSCEEK---TEIEEKGSLEIANMTEL 324
KL Q+ + K++ + S EE+ T++ K + I + E
Sbjct: 764 LIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKER 823
Query: 325 TKKI--ELLEHL-----NCQIRQTNKELENKLATMGTES-------KAVSSPSKKGSPLI 370
+ K+ EL ++ N +RQT +E + L +M E+ + + + +P+
Sbjct: 824 SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVA 883
Query: 371 SRKSGRNTASKMKSPWSQLSS--ETLNQDTD--KKINKNEIAKLEMVIQSLNKDLVDKEY 426
K+ ++ +++ S SQL++ E L ++ +KI +++ ++QSL + + +
Sbjct: 884 DPKT-LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
Query: 427 VISEKDTXXXXXXXXXXGKDTLIAQLQ-----LEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
+ + KD I LQ ++ Q H E + T+ D+ + KV
Sbjct: 943 FRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD---IQTDNSDIFQETKV 999
Query: 482 QEQLKQELNDEIKDVNVKD---LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
Q L E E D++ + L++ +K E +I LN++ + K + ++ + KL
Sbjct: 1000 QS-LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLT 1058
Query: 539 QM--QKTIDN---FSKVSDSN--KEIVRLTEELHHLS---QKVAELEEEKGNLQLHLVDY 588
Q+ QK ++ +++S ++ +++V L ++L + +KV + EK HL
Sbjct: 1059 QIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKT- 1117
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL-----HILQQKYDEVEDK 643
+ +M++ V K + L + K + ES D+ +E I+++K E+ D
Sbjct: 1118 EYHKMMDI-VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEI-DA 1175
Query: 644 LADISQ-----LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ Q LQ+ +E V+ Q + L + +L ++ ++ K+Q+ T+++
Sbjct: 1176 LSQKCQTLLAVLQTSSTGNEAGGVN-SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQN 1234
Query: 699 LENDKEDI---MNKLQNYIQENMDLTDKLEKMSA---EKISELLAKINHEEQSKIQTQFG 752
++++ + +++LQ + + D KL+ + + K+ + Q Q Q
Sbjct: 1235 MQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS 1294
Query: 753 IDAKIQERDLYIENIE--------SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
I +DL + ++ + L +S C V+ + L+++ ++L
Sbjct: 1295 IGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK 1354
Query: 805 YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
LQEK L + +A + +R +Q + KE Q Q LL+E
Sbjct: 1355 SLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDL 1414
Query: 865 LQISLSDMQQHYNA-LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI-VQKK 922
L + SD N K N +L T + ++ LE ++ ++ E++ ++ +
Sbjct: 1415 LIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRG 1474
Query: 923 KEIEDLEI-EFNTQIESAIRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
KE E + E N + +R+K+ + EK + + L+ + Q + L V+
Sbjct: 1475 KETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKS 1534
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYI--NEINKLNALLKQKDEEIIALNQKINNAQVS 1038
+ + + + Q E NE+ +L + ++E+ L + ++ S
Sbjct: 1535 MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDS 1594
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI-LVREQDDQI-KELK 1096
Y E + A+ K+ +EE++ S +++ H +Q+ ++EQ + + K+
Sbjct: 1595 YTREALAAEDREAKLRKKVTVLEEKLVS-SSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
ET L F ++ + + + ++ + + + +++++++ I E
Sbjct: 1654 ETALRFCLSGTVKQYRLSLANLQMVLEHFQQEEKAMYSA-------ELEKQKQLIAEWKK 1706
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E LQEC + + LT V +EQI +LK + E D++
Sbjct: 1707 NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1766
Query: 1217 VAELRSSISSAVDQ 1230
+ L +S VD+
Sbjct: 1767 LMSLANSSEGKVDK 1780
Score = 89.0 bits (211), Expect = 1e-16
Identities = 198/1110 (17%), Positives = 452/1110 (40%), Gaps = 93/1110 (8%)
Query: 484 QLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
+L+Q L+D ++ + + S E +L I+ K + S K +L+
Sbjct: 389 RLRQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEK-SLLSQEKEELQMSLLK 447
Query: 544 IDN-FSKVSDSNKEIVRLTEELH----HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV 598
++N + + + + L ELH +L K EL + + + + + +
Sbjct: 448 LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507
Query: 599 YKKMIEME-NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
K MI ++ L++ + + S++ K DL E +++ ++ED DI++ Q
Sbjct: 508 TKHMILIKAQLSKQQNEGDSIISKLKQDLNDE----KKRVHQLEDDKMDITKELDVQFVL 563
Query: 658 EIKSVHLEEQIDALSASKKELALVIENL--KLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
I+S E ++ L +K++L +ENL +L+K Q ++ KE++ +L+ +I+
Sbjct: 564 LIQS---EVALNDLHLTKQKLEDKVENLVDQLNKSQ----ESNVSIQKENL--ELKEHIR 614
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
+N + ++ +EL+ +N + S + D ++ER+ + N++ LS+ +
Sbjct: 615 QNEEELSRIR-------NELMQSLNQDSNSNFK-----DTLLKEREAEVRNLKQNLSELE 662
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR 835
L++ ++ L + + L+E ++ +++++ +V L +
Sbjct: 663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKM---EKG 719
Query: 836 VVEKQLLEIEHENKELQKKNQILLEENQNLQ-ISLSDMQQHYNALVEKANRTDLAESEST 894
+E +L + E K + +EE N + ++ S +Q + L++ + D+ +E
Sbjct: 720 EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELK 779
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
K + ++++ K T + + ++++K++ L + IE L E+ +K
Sbjct: 780 K---NIEQMDTDHKE-TKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYS 835
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT------QSPDYTEQYI 1008
+ + + E Q + +L EE N + EL ++ +T ++ D +
Sbjct: 836 QALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELA 895
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
+E+++LN + + +EEI + I + S M ++ + + + + E+M
Sbjct: 896 SEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEM-DEFRYQHEQMNATH 954
Query: 1069 KQL-LDSKQHNEELQILVREQDDQIKELKETKLTFEMNI---PKTEGMIISSTIEPMSDD 1124
QL L+ + + LQ + + Q+ E ++ T +I K + + I + E
Sbjct: 955 TQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS 1014
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTE 1184
+ +K+ E+ + + Q ++ Q K ++++ L+
Sbjct: 1015 KAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHAR 1074
Query: 1185 L--TGH--DVVNQEQ---------------INQLKSKLEQLNTENDNLLSTVAELRSSIS 1225
+ T H DVV +Q +N+ + L TE ++ VA +++
Sbjct: 1075 ISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
Query: 1226 SAVDQR---GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ-SSTQE 1281
D+ + + + + E +++ A K + LL +Q SST
Sbjct: 1135 KLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGN 1194
Query: 1282 ETNKIVT--MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXX 1339
E + + E++ ++KL+ + + + +++ + ++ +++++E
Sbjct: 1195 EAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVL 1254
Query: 1340 XXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE 1399
D QSY+Q E + N +E AQ++ S ++ D
Sbjct: 1255 VDSDNNSKLQVDYTGLIQSYEQ-NETKLKNFGQELAQVQHSIGQLCNTKDLLLGKL-DII 1312
Query: 1400 AKVLELTHQLELKDSEIYQKTHEYTITLTQR--NDEFENVRQQLVEYEKRIEDLTYEKES 1457
+ L L + +E + + ++ + E E +R+ L E + I T ++ +
Sbjct: 1313 SPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIR--TLQENN 1370
Query: 1458 ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
+ E Q +SEI+++K +++ K+ + L L KA +++
Sbjct: 1371 HRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDL------LIKAKSDQLL 1424
Query: 1518 KTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
+NE T N+ E L +TNL+ +
Sbjct: 1425 SSNENFT---NKVNENELLRQAVTNLKERI 1451
>BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 116 bits (278), Expect = 9e-25
Identities = 195/1081 (18%), Positives = 451/1081 (41%), Gaps = 93/1081 (8%)
Query: 212 EDTKQQMTKMQENFIAME---AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS 268
+ TK++ K + +E ++ +EK L + ++++ + EE L A + E+
Sbjct: 862 QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 921
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQ--SIEPSCEEKTEIEEKGSLEIANMTELTK 326
++ LE+ +A+Q +E EE+ +K LE K
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 327 KIE----LLEHLNCQIRQTNKELENKLATMGT-------ESKAVSSPSKKGSPLISR--- 372
K+E +++ N ++ + K LE +++ + T ++K ++ K +IS
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 373 -----KSGRNTASKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQS----LNK 419
+ R K+K +S+ Q D + K ++AK E +Q+ L+
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 420 DLVDKEYVISEKDTXXXXXXXXXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEI 478
++ K + + D+ A+ + E Q+ G L + T ED +
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
Q++L+ + E+ V K L E+ +S E Q+ ++ + A + + + +L+
Sbjct: 1162 TATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLE 1213
Query: 539 QMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRM 593
Q ++ N K + KE L EL L Q E+E +K L+ + + S G
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
+++ K+ +++N E+ ++ E + L +++ L + + ++ L + ++ Q
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKL 1332
Query: 654 QVCSEIKSVH-----LEEQIDALSASKKELALVIENLKLD----KEQLY---GTIKDLEN 701
V ++++ + L++Q+D +K+ L I L + K++L T++ LE
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 702 DKEDIMNKLQNYIQ---ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K+ +++N Q E DKLEK + ++ + L + + ++ Q ++ K +
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ D + ++ SKY R E E + SL R ++ +E ++
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1511
Query: 819 QEDELVN-------RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
+ ++LV+ + L R +E Q+ E++ + +EL+ + Q + L++++
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
++ + ++ R + E + + Q QL + E+ L+ + KKK DL+ +
Sbjct: 1572 LKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-D 1628
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
Q +SAI+ + E+ I+ + +L+AQ+++++ +E+ + +E+ +
Sbjct: 1629 LELQADSAIKGR-------EEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAKE 1677
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YES 1048
+ +K ++ D Q ++ KQ D E L +++ ++ ++ + E+
Sbjct: 1678 NEKKAKSLEADLM-QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
++AQ +LE + M+ +S ++ + Q E+L + + ++ + + E
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER---- 1792
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+ + S + M + ++ E+ +E+ + + + +L
Sbjct: 1793 -QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+E ++ + + ++ QLK +LE+ E+ + + +L+ + A
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 1229 D 1229
+
Sbjct: 1912 E 1912
Score = 115 bits (277), Expect = 1e-24
Identities = 215/1125 (19%), Positives = 478/1125 (42%), Gaps = 98/1125 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEK---INEKDQIIEAKNKATTXXXXXX 200
VT ++ K++ L + + + E + +L++K + E+ +++ + +A T
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
++ ++ + +M+ +E E +D Q+L + + ++ LEE +
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR---LEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
EAAR ++ LE ++++ L+K E+ +EE+ S N
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTN 1014
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
+ E +K + L L + ELE +L E K S++ + RK AS
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDAS 1065
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ L ++ + ++ K E +L+ + L+ ++ K + +
Sbjct: 1066 DFHEQIADLQAQI--AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 441 XXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKK 1181
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
L E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENA 1234
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLK 614
L EL L Q E+E +K L+ + + S G +++ K+ +++N E+
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
++ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 670 ALSASKKELALVIENLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMD 719
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 1414 AYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMD 832
R E E + SL R ++ +E + KA E + +D++ + L
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEK 1590
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVL 946
+ Q QL + E+ L+ + KKK +++DLE++ ++ I E AI+ + L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 947 N---EKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +++ +E ++ A +E + ++L ++ +L + +L ++ ++ +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLE 1709
Query: 1000 SPDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ E+ + ++ NAL +K + I L +++ Q M +SD K Q +
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQ 1768
Query: 1057 LENMEEEMQRVSKQLLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTE 1110
L N E +R + Q +S ++ N+EL+ + E + +K + K T E I + E
Sbjct: 1769 LSN-ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ E A L+V++E + ++ +EQ+ K N +++
Sbjct: 1828 EQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQ 1881
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
++ + E + + + Q ++++ E + E + L S
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 113 bits (273), Expect = 4e-24
Identities = 180/980 (18%), Positives = 405/980 (41%), Gaps = 50/980 (5%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 977
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 1098 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 1150
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 1268
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 1329 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 1384
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVE 838
LE ++ ++ + L+ + +Q ++ Q+ EY + EDE R A+ + +E
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLE 1623
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + +
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEK 1680
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 1681 KAKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKE 1796
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 1797 LRSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 1078 NEELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 1851 LKEILLQVEDERKMAEQYKE 1870
Score = 109 bits (263), Expect = 6e-23
Identities = 192/966 (19%), Positives = 413/966 (42%), Gaps = 105/966 (10%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA 508
+AQ L+ ++ +E E V AK+++ L+ E+ + D L ++ K
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK-LEDEIL--VMDDQNNKLSKERKLL 1004
Query: 509 EEQITQLNDEI---DAANKNMIKVKSNHK-------LKLKQMQKTIDNFSKV-------- 550
EE+I+ L + + KN+ K+K+ H+ ++LK+ +K+ K+
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---- 606
SD +++I L ++ L ++A+ EEE LQ L D +++ KK+ E+E
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 607 NLAE---TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKS 661
+L E + A + E QK DL +EL L+ + ++ D A +L++ +Q + +K
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 662 VHLEE------QIDAL----SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
EE Q+ + + + +EL +E K K L + LE + D+ +L+
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
Q ++ K +K+ A+ + EL +K + E+++ + ++ K+ + +E++ L
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1296
Query: 772 SKYKSRICRLEESIAVM----EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
++ + + +L + +A + +D + L+ + Q + + ++ E +D+L +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ +R + +++ K+LQ + L E + Q + ++ Q Y EKA
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAA 1413
Query: 885 RTDLAESESTKYQTQL----------RDLESNLKRITHEHQTLIVQKKK-------EIED 927
D E + Q +L R L SNL++ + L+ ++K E +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 928 LEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKM 984
E E + A+ + L E E + +E + L+A++++ ++ +++ NV EL K
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 985 NLELIDKHVQKQQTQSPDYTEQY-INEINKLN------ALLKQKDEEIIALNQKINNAQV 1037
L + +++ +TQ + ++ E KL AL Q + ++ A +++ +
Sbjct: 1534 KRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI--LVREQDDQIKEL 1095
+ +YE++L E + + +K+ L+ + ELQ ++ +++ IK+L
Sbjct: 1593 QLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 1096 KETKLTF-----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ----- 1145
++ + E+ + I +T + A +++ +
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1146 -EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E+EE +E + L E + +I QLE E G+ +++ + + E
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
QL+ E ST A+ S ++++ E+ + ++ F+ T L +++
Sbjct: 1768 QLSNELATERST-AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E + EQ Q++T+ K ++++ + E + EK + Q++
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 1325 SEIEDE 1330
E E+E
Sbjct: 1887 EEAEEE 1892
Score = 103 bits (246), Expect = 7e-21
Identities = 177/876 (20%), Positives = 364/876 (41%), Gaps = 55/876 (6%)
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENI----ESELSKYKSR--ICRLEE 783
K EL + QSKI + G+ A ++E RDL I ++ ++ Y +R + ++
Sbjct: 752 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQ 811
Query: 784 SIAVME--DRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ M+ R + K + L K K + T QE+E+ + L + E+Q
Sbjct: 812 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ---KTKERQ 868
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E+E KEL++K+ L EE LQ L + Y E R LA ++ + + L
Sbjct: 869 Q-KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--RVRLA-AKKQELEEIL 924
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNTQIESAIRDKKVLNE-KYEKNIEYVT 958
++E+ L+ Q L ++KK + L++E + E A R K L + E I+ +
Sbjct: 925 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 959 QLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNA 1016
+ + N + +EE ++ + L ++ + K T+ + E I+E+
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-K 1075
++ +E+ L +K+ + ++D ++++A+ +L EEE+Q +L D
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104
Query: 1076 QHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
Q N L+ +RE + I +L+E N + + + +E + + +
Sbjct: 1105 QKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED----TL 1159
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVN 1192
L+ + E+E + L E++ ++QE K Q +E L +L +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL---EQFK 1216
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ + N K+K + L EN +L + L V+ + ++ E Q L + +D ++
Sbjct: 1217 RAKANLDKNK-QTLEKENADLAGELRVL-GQAKQEVEHKKKKL-EAQVQELQSKCSDGER 1273
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEHLRNLQE 1311
EL ++ +++ E SV E K + + + V SL ++LQD +E L+
Sbjct: 1274 ARAELNDKVHKLQNEVE----SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 1312 KYADV---INQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QM 1362
+ +V + Q+E R+ ++ DE++ D + + Q + +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
E+ +E L + N + ++ +L L+ ++ +
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLEK 1448
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
Q E +N+ + + R E EKE++ L + E E +++ +++
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 1483 ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
+ ++ E+L ++ + K V EL K+ + EM+T LE E E+ D
Sbjct: 1509 LKAEM-EDL---VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+ ++A + ++ + + + + QL +++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 89.8 bits (213), Expect = 7e-17
Identities = 178/834 (21%), Positives = 337/834 (40%), Gaps = 76/834 (9%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E EL K K R + E + +E + L + + L LQ + + Y+E +E+ RL
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE----AEEMRVRL 913
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + +E+ L E+E +E + + Q L E + + + D+++ E+A R
Sbjct: 914 AA---KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQK 968
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + E + +++ LE + + + + +++K +E+ + T + K L
Sbjct: 969 L-QLEKVTAEAKIKKLEDEI-LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL-NKMNLELIDKHVQ--KQQTQSPDYT 1004
+ K+ +++LE +L++ + + + L E+L K+ + D H Q Q Q +
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 1005 EQYINEINKLNALLKQKDEEIIALN---QKINNAQVSYMSMVSDYESKLA---QFTTKLE 1058
Q + +L A L + D+EI N +KI + + D +S+ A + +
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 1059 NMEEEMQRVSKQL---LDSKQHNEELQILVREQDDQI--KELKETKLTFEMNIPKTEGM- 1112
++ EE++ + +L LDS +EL+ REQ+ + K L E + E + +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELR-AKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 1113 -----IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++ +E N+D L E Q + ++ + KL +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+QE +K E EL +D V++ Q N+++S LN + ++ +S+SS
Sbjct: 1261 VQELQSKCSDGERARAEL--NDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDV-ASLSSQ 1316
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EL ++ Q+ +LR QL + + LD + Q I
Sbjct: 1317 LQ----DTQELLQEETRQK----LNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 1288 TME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
T+ Q++ + KLQD + L+E +IE L + E EK A
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLEKTKNRLQ 1426
Query: 1347 XXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
DL + + +Q+ E+ ++ A+ K S + E K L
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
L LE E + E T E E++ + K + +L K + L
Sbjct: 1487 SLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA----LE 1538
Query: 1464 LKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+M E E ++ E + E KL E+N++ + + +L E+ K ++
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFERDLQARDEQNEEKRRQL 1594
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFASDTK-QGRDEQL 1572
Q L E E L DE + + A+ K++ K + +D+ +GR+E +
Sbjct: 1595 QRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Score = 87.8 bits (208), Expect = 3e-16
Identities = 126/640 (19%), Positives = 264/640 (41%), Gaps = 36/640 (5%)
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +LQ+ K + ++EL + + +L + K++ ++Q Q+ E+ A K
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
Q+ EEI+ + + + K+AQ LE EE + ++Q L ++
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTA 976
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +I E + + + + KL+ E + + +++ + + A N+
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
L+V+ ++E + R L++ KL + + + +I L+ EL +E++
Sbjct: 1037 SELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L+ + +N L + EL IS + +L + A+ +A+ QK +L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGE 1146
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYAD 1315
+L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 1147 ELEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 1365 -QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQE 1322
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESE 1481
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1482 I-ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDE 1539
V+ +EE + + + Q E A +++ KT N +Q L++ +++
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
++NL+ R + + + +S RD KE
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Score = 85.8 bits (203), Expect = 1e-15
Identities = 179/917 (19%), Positives = 371/917 (40%), Gaps = 91/917 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 1007 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 1364 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K K+ ++Q+ +D+ D+ +++V E+ ++ L EEK +
Sbjct: 1419 EKTKN-------RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL--LAEEKNISSKYAD 1469
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ D + K + + E L+A LE L E+ L D+V + +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 647 I--SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ S+ + E+K+ LEE D L A++ + N++ K Q ++ + E
Sbjct: 1530 LEKSKRALETQMEEMKT-QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 705 DIMNKLQNYIQE-NMDLTDK-----LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +LQ + E +L D+ L + +K+ L + + S I+ + +++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ +++ + EL ++ + + E + SLE QL L ++A + +
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 819 QEDELVNRLA-------VLMDHDRVVEKQLLEIEHENKELQ-----------KKNQILLE 860
+++EL LA L D R +E ++ ++E E +E Q K Q +
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 861 ENQNLQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITH 912
+ L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQE 966
+ + +K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 967 YKNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 1889 AEEESQRINANRRKLQR 1905
Score = 78.2 bits (184), Expect = 2e-13
Identities = 128/640 (20%), Positives = 270/640 (42%), Gaps = 47/640 (7%)
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLE 332
KLA+++ +Q + S + + EE+ SL+ E+ K L
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 333 H---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMKSPWSQ 388
H LN Q+ + K+L++ +T+ + K+ L + + A K++ ++
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
L E + D + ++ LE + ++ L +++ + S+ K+T
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVNVKD-----LI 502
L ++ +E + E N++ K + E L +D K+V+ + L
Sbjct: 1485 ALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
+++ + Q+ +L DE+ A ++++ N + Q ++ + + ++ + +L
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQR 1596
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLL 619
+LH ELE+E+ L + + +E D+ ++ ++ + R +K + L
Sbjct: 1597 QLHEYE---TELEDERKQRALAAA---AKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
++Q D +EL + DE+ A + + E + L+E + A ++K+
Sbjct: 1651 QAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTDKLEKMS--AE 730
L E L + L+++K + + +L+ ++E NM+ ++D++ K + AE
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVME 789
++S LA Q + ++ + +E + +E + SK+KS I LE IA +E
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HDRV--VEKQLL 842
++ R+ L++K K E +Q EDE + + + + RV +++QL
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
E E E++ + + L E S M + NAL K
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
>BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 116 bits (278), Expect = 9e-25
Identities = 195/1081 (18%), Positives = 451/1081 (41%), Gaps = 93/1081 (8%)
Query: 212 EDTKQQMTKMQENFIAME---AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS 268
+ TK++ K + +E ++ +EK L + ++++ + EE L A + E+
Sbjct: 862 QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 921
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQ--SIEPSCEEKTEIEEKGSLEIANMTELTK 326
++ LE+ +A+Q +E EE+ +K LE K
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 327 KIE----LLEHLNCQIRQTNKELENKLATMGT-------ESKAVSSPSKKGSPLISR--- 372
K+E +++ N ++ + K LE +++ + T ++K ++ K +IS
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 373 -----KSGRNTASKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQS----LNK 419
+ R K+K +S+ Q D + K ++AK E +Q+ L+
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 420 DLVDKEYVISEKDTXXXXXXXXXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEI 478
++ K + + D+ A+ + E Q+ G L + T ED +
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
Q++L+ + E+ V K L E+ +S E Q+ ++ + A + + + +L+
Sbjct: 1162 TATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLE 1213
Query: 539 QMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRM 593
Q ++ N K + KE L EL L Q E+E +K L+ + + S G
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
+++ K+ +++N E+ ++ E + L +++ L + + ++ L + ++ Q
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKL 1332
Query: 654 QVCSEIKSVH-----LEEQIDALSASKKELALVIENLKLD----KEQLY---GTIKDLEN 701
V ++++ + L++Q+D +K+ L I L + K++L T++ LE
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 702 DKEDIMNKLQNYIQ---ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K+ +++N Q E DKLEK + ++ + L + + ++ Q ++ K +
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ D + ++ SKY R E E + SL R ++ +E ++
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1511
Query: 819 QEDELVN-------RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
+ ++LV+ + L R +E Q+ E++ + +EL+ + Q + L++++
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
++ + ++ R + E + + Q QL + E+ L+ + KKK DL+ +
Sbjct: 1572 LKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-D 1628
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
Q +SAI+ + E+ I+ + +L+AQ+++++ +E+ + +E+ +
Sbjct: 1629 LELQADSAIKGR-------EEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAKE 1677
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YES 1048
+ +K ++ D Q ++ KQ D E L +++ ++ ++ + E+
Sbjct: 1678 NEKKAKSLEADLM-QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
++AQ +LE + M+ +S ++ + Q E+L + + ++ + + E
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER---- 1792
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+ + S + M + ++ E+ +E+ + + + +L
Sbjct: 1793 -QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+E ++ + + ++ QLK +LE+ E+ + + +L+ + A
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 1229 D 1229
+
Sbjct: 1912 E 1912
Score = 115 bits (277), Expect = 1e-24
Identities = 215/1125 (19%), Positives = 478/1125 (42%), Gaps = 98/1125 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEK---INEKDQIIEAKNKATTXXXXXX 200
VT ++ K++ L + + + E + +L++K + E+ +++ + +A T
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
++ ++ + +M+ +E E +D Q+L + + ++ LEE +
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR---LEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
EAAR ++ LE ++++ L+K E+ +EE+ S N
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTN 1014
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
+ E +K + L L + ELE +L E K S++ + RK AS
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDAS 1065
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ L ++ + ++ K E +L+ + L+ ++ K + +
Sbjct: 1066 DFHEQIADLQAQI--AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 441 XXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKK 1181
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
L E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENA 1234
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLK 614
L EL L Q E+E +K L+ + + S G +++ K+ +++N E+
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
++ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 670 ALSASKKELALVIENLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMD 719
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 1414 AYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMD 832
R E E + SL R ++ +E + KA E + +D++ + L
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEK 1590
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVL 946
+ Q QL + E+ L+ + KKK +++DLE++ ++ I E AI+ + L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 947 N---EKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +++ +E ++ A +E + ++L ++ +L + +L ++ ++ +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLE 1709
Query: 1000 SPDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ E+ + ++ NAL +K + I L +++ Q M +SD K Q +
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQ 1768
Query: 1057 LENMEEEMQRVSKQLLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTE 1110
L N E +R + Q +S ++ N+EL+ + E + +K + K T E I + E
Sbjct: 1769 LSN-ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ E A L+V++E + ++ +EQ+ K N +++
Sbjct: 1828 EQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQ 1881
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
++ + E + + + Q ++++ E + E + L S
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 113 bits (273), Expect = 4e-24
Identities = 180/980 (18%), Positives = 405/980 (41%), Gaps = 50/980 (5%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 977
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 1098 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 1150
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 1268
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 1329 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 1384
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVE 838
LE ++ ++ + L+ + +Q ++ Q+ EY + EDE R A+ + +E
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLE 1623
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + +
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEK 1680
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 1681 KAKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKE 1796
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 1797 LRSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 1078 NEELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 1851 LKEILLQVEDERKMAEQYKE 1870
Score = 109 bits (263), Expect = 6e-23
Identities = 192/966 (19%), Positives = 413/966 (42%), Gaps = 105/966 (10%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA 508
+AQ L+ ++ +E E V AK+++ L+ E+ + D L ++ K
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK-LEDEIL--VMDDQNNKLSKERKLL 1004
Query: 509 EEQITQLNDEI---DAANKNMIKVKSNHK-------LKLKQMQKTIDNFSKV-------- 550
EE+I+ L + + KN+ K+K+ H+ ++LK+ +K+ K+
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---- 606
SD +++I L ++ L ++A+ EEE LQ L D +++ KK+ E+E
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 607 NLAE---TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKS 661
+L E + A + E QK DL +EL L+ + ++ D A +L++ +Q + +K
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 662 VHLEE------QIDAL----SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
EE Q+ + + + +EL +E K K L + LE + D+ +L+
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
Q ++ K +K+ A+ + EL +K + E+++ + ++ K+ + +E++ L
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1296
Query: 772 SKYKSRICRLEESIAVM----EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
++ + + +L + +A + +D + L+ + Q + + ++ E +D+L +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ +R + +++ K+LQ + L E + Q + ++ Q Y EKA
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAA 1413
Query: 885 RTDLAESESTKYQTQL----------RDLESNLKRITHEHQTLIVQKKK-------EIED 927
D E + Q +L R L SNL++ + L+ ++K E +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 928 LEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKM 984
E E + A+ + L E E + +E + L+A++++ ++ +++ NV EL K
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 985 NLELIDKHVQKQQTQSPDYTEQY-INEINKLN------ALLKQKDEEIIALNQKINNAQV 1037
L + +++ +TQ + ++ E KL AL Q + ++ A +++ +
Sbjct: 1534 KRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI--LVREQDDQIKEL 1095
+ +YE++L E + + +K+ L+ + ELQ ++ +++ IK+L
Sbjct: 1593 QLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 1096 KETKLTF-----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ----- 1145
++ + E+ + I +T + A +++ +
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1146 -EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E+EE +E + L E + +I QLE E G+ +++ + + E
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
QL+ E ST A+ S ++++ E+ + ++ F+ T L +++
Sbjct: 1768 QLSNELATERST-AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E + EQ Q++T+ K ++++ + E + EK + Q++
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 1325 SEIEDE 1330
E E+E
Sbjct: 1887 EEAEEE 1892
Score = 103 bits (246), Expect = 7e-21
Identities = 177/876 (20%), Positives = 364/876 (41%), Gaps = 55/876 (6%)
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENI----ESELSKYKSR--ICRLEE 783
K EL + QSKI + G+ A ++E RDL I ++ ++ Y +R + ++
Sbjct: 752 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQ 811
Query: 784 SIAVME--DRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ M+ R + K + L K K + T QE+E+ + L + E+Q
Sbjct: 812 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ---KTKERQ 868
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E+E KEL++K+ L EE LQ L + Y E R LA ++ + + L
Sbjct: 869 Q-KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--RVRLA-AKKQELEEIL 924
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNTQIESAIRDKKVLNE-KYEKNIEYVT 958
++E+ L+ Q L ++KK + L++E + E A R K L + E I+ +
Sbjct: 925 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 959 QLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNA 1016
+ + N + +EE ++ + L ++ + K T+ + E I+E+
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-K 1075
++ +E+ L +K+ + ++D ++++A+ +L EEE+Q +L D
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104
Query: 1076 QHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
Q N L+ +RE + I +L+E N + + + +E + + +
Sbjct: 1105 QKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED----TL 1159
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVN 1192
L+ + E+E + L E++ ++QE K Q +E L +L +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL---EQFK 1216
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ + N K+K + L EN +L + L V+ + ++ E Q L + +D ++
Sbjct: 1217 RAKANLDKNK-QTLEKENADLAGELRVL-GQAKQEVEHKKKKL-EAQVQELQSKCSDGER 1273
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEHLRNLQE 1311
EL ++ +++ E SV E K + + + V SL ++LQD +E L+
Sbjct: 1274 ARAELNDKVHKLQNEVE----SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 1312 KYADV---INQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QM 1362
+ +V + Q+E R+ ++ DE++ D + + Q + +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
E+ +E L + N + ++ +L L+ ++ +
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLEK 1448
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
Q E +N+ + + R E EKE++ L + E E +++ +++
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 1483 ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
+ ++ E+L ++ + K V EL K+ + EM+T LE E E+ D
Sbjct: 1509 LKAEM-EDL---VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+ ++A + ++ + + + + QL +++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 89.8 bits (213), Expect = 7e-17
Identities = 178/834 (21%), Positives = 337/834 (40%), Gaps = 76/834 (9%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E EL K K R + E + +E + L + + L LQ + + Y+E +E+ RL
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE----AEEMRVRL 913
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + +E+ L E+E +E + + Q L E + + + D+++ E+A R
Sbjct: 914 AA---KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQK 968
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + E + +++ LE + + + + +++K +E+ + T + K L
Sbjct: 969 L-QLEKVTAEAKIKKLEDEI-LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL-NKMNLELIDKHVQ--KQQTQSPDYT 1004
+ K+ +++LE +L++ + + + L E+L K+ + D H Q Q Q +
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 1005 EQYINEINKLNALLKQKDEEIIALN---QKINNAQVSYMSMVSDYESKLA---QFTTKLE 1058
Q + +L A L + D+EI N +KI + + D +S+ A + +
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 1059 NMEEEMQRVSKQL---LDSKQHNEELQILVREQDDQI--KELKETKLTFEMNIPKTEGM- 1112
++ EE++ + +L LDS +EL+ REQ+ + K L E + E + +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELR-AKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 1113 -----IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++ +E N+D L E Q + ++ + KL +
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+QE +K E EL +D V++ Q N+++S LN + ++ +S+SS
Sbjct: 1261 VQELQSKCSDGERARAEL--NDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDV-ASLSSQ 1316
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EL ++ Q+ +LR QL + + LD + Q I
Sbjct: 1317 LQ----DTQELLQEETRQK----LNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 1288 TME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
T+ Q++ + KLQD + L+E +IE L + E EK A
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLEKTKNRLQ 1426
Query: 1347 XXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
DL + + +Q+ E+ ++ A+ K S + E K L
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
L LE E + E T E E++ + K + +L K + L
Sbjct: 1487 SLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA----LE 1538
Query: 1464 LKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+M E E ++ E + E KL E+N++ + + +L E+ K ++
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFERDLQARDEQNEEKRRQL 1594
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFASDTK-QGRDEQL 1572
Q L E E L DE + + A+ K++ K + +D+ +GR+E +
Sbjct: 1595 QRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Score = 87.8 bits (208), Expect = 3e-16
Identities = 126/640 (19%), Positives = 264/640 (41%), Gaps = 36/640 (5%)
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +LQ+ K + ++EL + + +L + K++ ++Q Q+ E+ A K
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
Q+ EEI+ + + + K+AQ LE EE + ++Q L ++
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTA 976
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +I E + + + + KL+ E + + +++ + + A N+
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
L+V+ ++E + R L++ KL + + + +I L+ EL +E++
Sbjct: 1037 SELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L+ + +N L + EL IS + +L + A+ +A+ QK +L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGE 1146
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYAD 1315
+L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 1147 ELEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 1365 -QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQE 1322
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESE 1481
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1482 I-ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDE 1539
V+ +EE + + + Q E A +++ KT N +Q L++ +++
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
++NL+ R + + + +S RD KE
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Score = 85.8 bits (203), Expect = 1e-15
Identities = 179/917 (19%), Positives = 371/917 (40%), Gaps = 91/917 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 1007 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 1364 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K K+ ++Q+ +D+ D+ +++V E+ ++ L EEK +
Sbjct: 1419 EKTKN-------RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL--LAEEKNISSKYAD 1469
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ D + K + + E L+A LE L E+ L D+V + +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 647 I--SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ S+ + E+K+ LEE D L A++ + N++ K Q ++ + E
Sbjct: 1530 LEKSKRALETQMEEMKT-QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 705 DIMNKLQNYIQE-NMDLTDK-----LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +LQ + E +L D+ L + +K+ L + + S I+ + +++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ +++ + EL ++ + + E + SLE QL L ++A + +
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 819 QEDELVNRLA-------VLMDHDRVVEKQLLEIEHENKELQ-----------KKNQILLE 860
+++EL LA L D R +E ++ ++E E +E Q K Q +
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 861 ENQNLQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITH 912
+ L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQE 966
+ + +K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 967 YKNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 1889 AEEESQRINANRRKLQR 1905
Score = 78.2 bits (184), Expect = 2e-13
Identities = 128/640 (20%), Positives = 270/640 (42%), Gaps = 47/640 (7%)
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLE 332
KLA+++ +Q + S + + EE+ SL+ E+ K L
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 333 H---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMKSPWSQ 388
H LN Q+ + K+L++ +T+ + K+ L + + A K++ ++
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
L E + D + ++ LE + ++ L +++ + S+ K+T
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVNVKD-----LI 502
L ++ +E + E N++ K + E L +D K+V+ + L
Sbjct: 1485 ALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
+++ + Q+ +L DE+ A ++++ N + Q ++ + + ++ + +L
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQR 1596
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLL 619
+LH ELE+E+ L + + +E D+ ++ ++ + R +K + L
Sbjct: 1597 QLHEYE---TELEDERKQRALAAA---AKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
++Q D +EL + DE+ A + + E + L+E + A ++K+
Sbjct: 1651 QAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTDKLEKMS--AE 730
L E L + L+++K + + +L+ ++E NM+ ++D++ K + AE
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVME 789
++S LA Q + ++ + +E + +E + SK+KS I LE IA +E
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HDRV--VEKQLL 842
++ R+ L++K K E +Q EDE + + + + RV +++QL
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
E E E++ + + L E S M + NAL K
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
>AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin heavy
chain isoform SM2 protein.
Length = 1945
Score = 116 bits (278), Expect = 9e-25
Identities = 195/1081 (18%), Positives = 451/1081 (41%), Gaps = 93/1081 (8%)
Query: 212 EDTKQQMTKMQENFIAME---AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEIS 268
+ TK++ K + +E ++ +EK L + ++++ + EE L A + E+
Sbjct: 869 QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 928
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQ--SIEPSCEEKTEIEEKGSLEIANMTELTK 326
++ LE+ +A+Q +E EE+ +K LE K
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 327 KIE----LLEHLNCQIRQTNKELENKLATMGT-------ESKAVSSPSKKGSPLISR--- 372
K+E +++ N ++ + K LE +++ + T ++K ++ K +IS
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 373 -----KSGRNTASKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQS----LNK 419
+ R K+K +S+ Q D + K ++AK E +Q+ L+
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 420 DLVDKEYVISEKDTXXXXXXXXXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEI 478
++ K + + D+ A+ + E Q+ G L + T ED +
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
Q++L+ + E+ V K L E+ +S E Q+ ++ + A + + + +L+
Sbjct: 1169 TATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLE 1220
Query: 539 QMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRM 593
Q ++ N K + KE L EL L Q E+E +K L+ + + S G
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
+++ K+ +++N E+ ++ E + L +++ L + + ++ L + ++ Q
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKL 1339
Query: 654 QVCSEIKSVH-----LEEQIDALSASKKELALVIENLKLD----KEQLY---GTIKDLEN 701
V ++++ + L++Q+D +K+ L I L + K++L T++ LE
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 702 DKEDIMNKLQNYIQ---ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K+ +++N Q E DKLEK + ++ + L + + ++ Q ++ K +
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ D + ++ SKY R E E + SL R ++ +E ++
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1518
Query: 819 QEDELVN-------RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
+ ++LV+ + L R +E Q+ E++ + +EL+ + Q + L++++
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
++ + ++ R + E + + Q QL + E+ L+ + KKK DL+ +
Sbjct: 1579 LKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-D 1635
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
Q +SAI+ + E+ I+ + +L+AQ+++++ +E+ + +E+ +
Sbjct: 1636 LELQADSAIKGR-------EEAIKQLRKLQAQMKDFQRELEDARASRDEI----FATAKE 1684
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YES 1048
+ +K ++ D Q ++ KQ D E L +++ ++ ++ + E+
Sbjct: 1685 NEKKAKSLEADLM-QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
++AQ +LE + M+ +S ++ + Q E+L + + ++ + + E
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER---- 1799
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+ + S + M + ++ E+ +E+ + + + +L
Sbjct: 1800 -QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+E ++ + + ++ QLK +LE+ E+ + + +L+ + A
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 1229 D 1229
+
Sbjct: 1919 E 1919
Score = 115 bits (277), Expect = 1e-24
Identities = 215/1125 (19%), Positives = 478/1125 (42%), Gaps = 98/1125 (8%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEK---INEKDQIIEAKNKATTXXXXXX 200
VT ++ K++ L + + + E + +L++K + E+ +++ + +A T
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
++ ++ + +M+ +E E +D Q+L + + ++ LEE +
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEAR---LEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
EAAR ++ LE ++++ L+K E+ +EE+ S N
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTN 1021
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
+ E +K + L L + ELE +L E K S++ + RK AS
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDAS 1072
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ L ++ + ++ K E +L+ + L+ ++ K + +
Sbjct: 1073 DFHEQIADLQAQI--AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 441 XXXGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKK 1188
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
L E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENA 1241
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLK 614
L EL L Q E+E +K L+ + + S G +++ K+ +++N E+
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQID 669
++ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 670 ALSASKKELALVIENLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMD 719
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 1421 AYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMD 832
R E E + SL R ++ +E + KA E + +D++ + L
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEK 1597
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVL 946
+ Q QL + E+ L+ + KKK +++DLE++ ++ I E AI+ + L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 947 N---EKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +++ +E ++ A +E + ++L ++ +L + +L ++ ++ +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLE 1716
Query: 1000 SPDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ E+ + ++ NAL +K + I L +++ Q M +SD K Q +
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQ 1775
Query: 1057 LENMEEEMQRVSKQLLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTE 1110
L N E +R + Q +S ++ N+EL+ + E + +K + K T E I + E
Sbjct: 1776 LSN-ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+ E A L+V++E + ++ +EQ+ K N +++
Sbjct: 1835 EQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQ 1888
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
++ + E + + + Q ++++ E + E + L S
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 113 bits (273), Expect = 4e-24
Identities = 180/980 (18%), Positives = 405/980 (41%), Gaps = 50/980 (5%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 984
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 1105 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 1157
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 1275
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 1336 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 1391
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVE 838
LE ++ ++ + L+ + +Q ++ Q+ EY + EDE R A+ + +E
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR-ALAAAAKKKLE 1630
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + +
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEK 1687
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 1688 KAKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKE 1803
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 1804 LRSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 1078 NEELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 1858 LKEILLQVEDERKMAEQYKE 1877
Score = 109 bits (263), Expect = 6e-23
Identities = 192/966 (19%), Positives = 413/966 (42%), Gaps = 105/966 (10%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA 508
+AQ L+ ++ +E E V AK+++ L+ E+ + D L ++ K
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK-LEDEIL--VMDDQNNKLSKERKLL 1011
Query: 509 EEQITQLNDEI---DAANKNMIKVKSNHK-------LKLKQMQKTIDNFSKV-------- 550
EE+I+ L + + KN+ K+K+ H+ ++LK+ +K+ K+
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---- 606
SD +++I L ++ L ++A+ EEE LQ L D +++ KK+ E+E
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 607 NLAE---TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKS 661
+L E + A + E QK DL +EL L+ + ++ D A +L++ +Q + +K
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 662 VHLEE------QIDAL----SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
EE Q+ + + + +EL +E K K L + LE + D+ +L+
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 712 NYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
Q ++ K +K+ A+ + EL +K + E+++ + ++ K+ + +E++ L
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGML 1303
Query: 772 SKYKSRICRLEESIAVM----EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
++ + + +L + +A + +D + L+ + Q + + ++ E +D+L +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ +R + +++ K+LQ + L E + Q + ++ Q Y EKA
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAA 1420
Query: 885 RTDLAESESTKYQTQL----------RDLESNLKRITHEHQTLIVQKKK-------EIED 927
D E + Q +L R L SNL++ + L+ ++K E +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 928 LEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKM 984
E E + A+ + L E E + +E + L+A++++ ++ +++ NV EL K
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 985 NLELIDKHVQKQQTQSPDYTEQY-INEINKLN------ALLKQKDEEIIALNQKINNAQV 1037
L + +++ +TQ + ++ E KL AL Q + ++ A +++ +
Sbjct: 1541 KRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI--LVREQDDQIKEL 1095
+ +YE++L E + + +K+ L+ + ELQ ++ +++ IK+L
Sbjct: 1600 QLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 1096 KETKLTF-----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ----- 1145
++ + E+ + I +T + A +++ +
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1146 -EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E+EE +E + L E + +I QLE E G+ +++ + + E
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
QL+ E ST A+ S ++++ E+ + ++ F+ T L +++
Sbjct: 1775 QLSNELATERST-AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E + EQ Q++T+ K ++++ + E + EK + Q++
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 1325 SEIEDE 1330
E E+E
Sbjct: 1894 EEAEEE 1899
Score = 103 bits (246), Expect = 7e-21
Identities = 177/876 (20%), Positives = 364/876 (41%), Gaps = 55/876 (6%)
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENI----ESELSKYKSR--ICRLEE 783
K EL + QSKI + G+ A ++E RDL I ++ ++ Y +R + ++
Sbjct: 759 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQ 818
Query: 784 SIAVME--DRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ M+ R + K + L K K + T QE+E+ + L + E+Q
Sbjct: 819 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ---KTKERQ 875
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E+E KEL++K+ L EE LQ L + Y E R LA ++ + + L
Sbjct: 876 Q-KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--RVRLA-AKKQELEEIL 931
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNTQIESAIRDKKVLNE-KYEKNIEYVT 958
++E+ L+ Q L ++KK + L++E + E A R K L + E I+ +
Sbjct: 932 HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 959 QLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNA 1016
+ + N + +EE ++ + L ++ + K T+ + E I+E+
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-K 1075
++ +E+ L +K+ + ++D ++++A+ +L EEE+Q +L D
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111
Query: 1076 QHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
Q N L+ +RE + I +L+E N + + + +E + + +
Sbjct: 1112 QKNNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED----TL 1166
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVN 1192
L+ + E+E + L E++ ++QE K Q +E L +L +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL---EQFK 1223
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ + N K+K + L EN +L + L V+ + ++ E Q L + +D ++
Sbjct: 1224 RAKANLDKNK-QTLEKENADLAGELRVL-GQAKQEVEHKKKKL-EAQVQELQSKCSDGER 1280
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEHLRNLQE 1311
EL ++ +++ E SV E K + + + V SL ++LQD +E L+
Sbjct: 1281 ARAELNDKVHKLQNEVE----SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 1312 KYADV---INQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QM 1362
+ +V + Q+E R+ ++ DE++ D + + Q + +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
E+ +E L + N + ++ +L L+ ++ +
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD-NQRQLVSNLEK 1455
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI 1482
Q E +N+ + + R E EKE++ L + E E +++ +++
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 1483 ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
+ ++ E+L ++ + K V EL K+ + EM+T LE E E+ D
Sbjct: 1516 LKAEM-EDL---VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+ ++A + ++ + + + + QL +++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 89.8 bits (213), Expect = 7e-17
Identities = 178/834 (21%), Positives = 337/834 (40%), Gaps = 76/834 (9%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E EL K K R + E + +E + L + + L LQ + + Y+E +E+ RL
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE----AEEMRVRL 920
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + +E+ L E+E +E + + Q L E + + + D+++ E+A R
Sbjct: 921 AA---KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQK 975
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
L + E + +++ LE + + + + +++K +E+ + T + K L
Sbjct: 976 L-QLEKVTAEAKIKKLEDEI-LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL-NKMNLELIDKHVQ--KQQTQSPDYT 1004
+ K+ +++LE +L++ + + + L E+L K+ + D H Q Q Q +
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 1005 EQYINEINKLNALLKQKDEEIIALN---QKINNAQVSYMSMVSDYESKLA---QFTTKLE 1058
Q + +L A L + D+EI N +KI + + D +S+ A + +
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 1059 NMEEEMQRVSKQL---LDSKQHNEELQILVREQDDQI--KELKETKLTFEMNIPKTEGM- 1112
++ EE++ + +L LDS +EL+ REQ+ + K L E + E + +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELR-AKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 1113 -----IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++ +E N+D L E Q + ++ + KL +
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-AGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+QE +K E EL +D V++ Q N+++S LN + ++ +S+SS
Sbjct: 1268 VQELQSKCSDGERARAEL--NDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDV-ASLSSQ 1323
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EL ++ Q+ +LR QL + + LD + Q I
Sbjct: 1324 LQ----DTQELLQEETRQK----LNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 1288 TME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
T+ Q++ + KLQD + L+E +IE L + E EK A
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLEKTKNRLQ 1433
Query: 1347 XXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
DL + + +Q+ E+ ++ A+ K S + E K L
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
L LE E + E T E E++ + K + +L K + L
Sbjct: 1494 SLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA----LE 1545
Query: 1464 LKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
+M E E ++ E + E KL E+N++ + + +L E+ K ++
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFERDLQARDEQNEEKRRQL 1601
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFASDTK-QGRDEQL 1572
Q L E E L DE + + A+ K++ K + +D+ +GR+E +
Sbjct: 1602 QRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Score = 87.8 bits (208), Expect = 3e-16
Identities = 126/640 (19%), Positives = 264/640 (41%), Gaps = 36/640 (5%)
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEINKLNALLK 1019
E +LQ+ K + ++EL + + +L + K++ ++Q Q+ E+ A K
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
Q+ EEI+ + + + K+AQ LE EE + ++Q L ++
Sbjct: 925 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTA 983
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
E +I E + + + + KL+ E + + +++ + + A N+
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
L+V+ ++E + R L++ KL + + + +I L+ EL +E++
Sbjct: 1044 SELEVRLKKEE-KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L+ + +N L + EL IS + +L + A+ +A+ QK +L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGE 1153
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYAD 1315
+L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 1154 ELEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 1365 -QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQE 1329
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESE 1481
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1482 I-ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDE 1539
V+ +EE + + + Q E A +++ KT N +Q L++ +++
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
++NL+ R + + + +S RD KE
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Score = 85.8 bits (203), Expect = 1e-15
Identities = 179/917 (19%), Positives = 371/917 (40%), Gaps = 91/917 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 1014 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 1371 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K K+ ++Q+ +D+ D+ +++V E+ ++ L EEK +
Sbjct: 1426 EKTKN-------RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL--LAEEKNISSKYAD 1476
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ D + K + + E L+A LE L E+ L D+V + +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 647 I--SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ S+ + E+K+ LEE D L A++ + N++ K Q ++ + E
Sbjct: 1537 LEKSKRALETQMEEMKT-QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 705 DIMNKLQNYIQE-NMDLTDK-----LEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +LQ + E +L D+ L + +K+ L + + S I+ + +++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ +++ + EL ++ + + E + SLE QL L ++A + +
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 819 QEDELVNRLA-------VLMDHDRVVEKQLLEIEHENKELQ-----------KKNQILLE 860
+++EL LA L D R +E ++ ++E E +E Q K Q +
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 861 ENQNLQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITH 912
+ L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQE 966
+ + +K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 967 YKNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 1896 AEEESQRINANRRKLQR 1912
Score = 78.2 bits (184), Expect = 2e-13
Identities = 128/640 (20%), Positives = 270/640 (42%), Gaps = 47/640 (7%)
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLE 332
KLA+++ +Q + S + + EE+ SL+ E+ K L
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 333 H---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMKSPWSQ 388
H LN Q+ + K+L++ +T+ + K+ L + + A K++ ++
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
L E + D + ++ LE + ++ L +++ + S+ K+T
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVNVKD-----LI 502
L ++ +E + E N++ K + E L +D K+V+ + L
Sbjct: 1492 ALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
+++ + Q+ +L DE+ A ++++ N + Q ++ + + ++ + +L
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQR 1603
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLL 619
+LH ELE+E+ L + + +E D+ ++ ++ + R +K + L
Sbjct: 1604 QLHEYE---TELEDERKQRALAAA---AKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
++Q D +EL + DE+ A + + E + L+E + A ++K+
Sbjct: 1658 QAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTDKLEKMS--AE 730
L E L + L+++K + + +L+ ++E NM+ ++D++ K + AE
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVME 789
++S LA Q + ++ + +E + +E + SK+KS I LE IA +E
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HDRV--VEKQLL 842
++ R+ L++K K E +Q EDE + + + + RV +++QL
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
E E E++ + + L E S M + NAL K
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
>X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy chain
(1085 AA) protein.
Length = 1085
Score = 115 bits (277), Expect = 1e-24
Identities = 201/1095 (18%), Positives = 461/1095 (42%), Gaps = 95/1095 (8%)
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMIEM 605
F K D E+ + + L +K+ L +EK +LQL V +S +++++ ++I+
Sbjct: 2 FQKTKD---ELAKSEAKRKELEEKLVTLVQEKNDLQLQ-VQAESENLLDAEERCDQLIKA 57
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYD--------EVEDKLADISQLQSDQVCS 657
+ E ++K ++ + ++ EL ++K + +++D +++++ ++ +
Sbjct: 58 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 117
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
E K +L E++ L + +L + L+ +Q ++ E DK + +NK ++ +++
Sbjct: 118 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ-AEEDKVNSLNKTKSKLEQQ 176
Query: 718 M-DLTDKLEKMSAEKIS------ELLAKINHEEQSKIQTQFG---IDAKIQERDLYIENI 767
+ DL LE+ ++ +L + ++S + + +D +++++D +
Sbjct: 177 VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQL 236
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+S++ ++ + ++ I ++ R LE + + + + +K S+Y + +EL RL
Sbjct: 237 QSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 296
Query: 828 -------AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
+ ++ ++ E + L++ + +E +++ ++ L+ +D +
Sbjct: 297 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV---ATLRKKHADSVAELGEQI 353
Query: 881 EKANRT-DLAESESTKYQTQLRDLESNLKRITHEH-------QTLIVQ------KKKEIE 926
+ R E E ++++ ++ DL S+++ ++ +TL Q K +EI+
Sbjct: 354 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 413
Query: 927 DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
E TQ + L+ + E+ V+QL Q + E L +EE NK
Sbjct: 414 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK- 472
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEIN---KLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+ +Q + EQY E +L L + + E+ K + +
Sbjct: 473 NALGHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 532
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQ----HNEELQILVREQDDQIKELK 1096
+ + KLAQ +L++ EE+++ V+ + L +KQ E+L + V + L
Sbjct: 533 EEAKKKLAQ---RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 589
Query: 1097 ETKLTFEMNIP--KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
+ + F+ + KT+ + +E ++ ++ + + E +E
Sbjct: 590 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE-ALDQLETVKREN 648
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
L+++ A L ++ E I +LE ++ Q + + ++ LE + +
Sbjct: 649 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 708
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYEQLL 1272
+ +++S I + ++ EI +L + + E + E+R A + K E L
Sbjct: 709 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDL 768
Query: 1273 DSVQSSTQEETNKIV-TMEQVTSLQNKLQDKEEHL-------RNLQEKYADVINQIEILR 1324
+ ++ + T++ + S+Q +L+D + HL +L+E+ A V + +L+
Sbjct: 769 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ 828
Query: 1325 SEIEDEKVAFXXXXXXXXXXXXXXXXD------LRTENQSYKQMQEQSILNINEENAQLK 1378
+E+E+ + L T+N S +++ ++ + ++++
Sbjct: 829 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVE 888
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFEN 1436
+S + DA EL + + E +K E T+ L R DE E
Sbjct: 889 DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 948
Query: 1437 V-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVK 1486
+ ++Q+ + E RI +L +E E E ++ L+ +E T Q E + + V
Sbjct: 949 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1008
Query: 1487 LIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
+++L K+ V S +Q E ++ + K + Q LE E ++ L+
Sbjct: 1009 RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1068
Query: 1546 MVR-ASSSKIQKHVS 1559
R +SS++ H S
Sbjct: 1069 KTRDFTSSRMVVHES 1083
Score = 99.5 bits (237), Expect = 9e-20
Identities = 183/934 (19%), Positives = 402/934 (43%), Gaps = 78/934 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLE--AARFEISLE 270
++++ + E + E K + Q+ L D+++++ +++SL + LE E SLE
Sbjct: 126 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 185
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K L +LE+ LA++SI +K +++E+ + +L K+E
Sbjct: 186 QEKKLRVDLERNKRKLEGDLK----LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 241
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q ++ KEL+ ++ + E +A + K + K + A +++ +L
Sbjct: 242 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-----TEKQRSDYARELEELSERL 296
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS--EKDTXXXXXXXXXXGKDT 447
T ++NK A+ + + L + + E +++ K +
Sbjct: 297 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNL 356
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK--DLIEKL 505
+ +LE ++ + + ++ E V++ E++ + L D++ + K ++ L
Sbjct: 357 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 416
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQ--MQKTIDNFSKVSDSNKEIVRLT 561
Q ++L E ++ + + +S + + KQ Q+T + ++ + NK L
Sbjct: 417 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALG 476
Query: 562 EELHH-------LSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMIEME--- 606
L L ++ E +E K LQ L +S E+D ++ E+E
Sbjct: 477 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 536
Query: 607 -NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
LA+ + +E+ Q+ EVED + D+ + S + K + +
Sbjct: 537 KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 596
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
+ + +E +E + L + L+N E+ +++L+ +EN +L ++
Sbjct: 597 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 656
Query: 726 KMSAEKISELLAKINHEEQSKIQTQF---GIDAKIQERDLYIEN-------IESELSKYK 775
++ E+I+E I+ E+S+ Q + I ++E + +E+ I+ EL++ K
Sbjct: 657 DLT-EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 715
Query: 776 SRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLM 831
S I R + E +E + + +R + + S L + + +E + ++ +N + + +
Sbjct: 716 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDLNEIEIQL 775
Query: 832 DH--DRVVE--KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--R 885
H + E K L ++ + K+ Q L ++L+ L+ +++ N L + R
Sbjct: 776 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELR 835
Query: 886 TDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
L ++E + + L+SN + ++ H T ++ KK++E ++ +++E A RD +
Sbjct: 836 ATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 895
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
EK +K I + +L++ ++ +L E K NLE K +Q + ++
Sbjct: 896 NAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQLA 950
Query: 1005 -EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ +I KL +++ + E+ QK N V + YE ++ + T + E +
Sbjct: 951 LKGGKKQIQKLETRIRELEFELEG-EQKKNTESVKGL---RKYERRVKELTYQSEEDRKN 1006
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ R+ + L+D +LQ+ V+ Q +E E
Sbjct: 1007 VLRL-QDLVD------KLQVKVKSYKRQAEEADE 1033
Score = 97.1 bits (231), Expect = 5e-19
Identities = 164/877 (18%), Positives = 368/877 (41%), Gaps = 51/877 (5%)
Query: 473 EDVN-EIAKVQEQLKQELNDEIKDVNVKDL----IEKLKSA-EEQITQLNDEIDAANKNM 526
E++N E+ + +L+ E ++ KD++ +L +EK K A E ++ L +E+ ++ +
Sbjct: 76 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI 135
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K+ K + Q+ +D+ D ++ L + L Q+V +LE + V
Sbjct: 136 AKLTREKKALQEAHQQALDDLQAEED---KVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 192
Query: 587 DYDSG-RMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
D + R +E D+ + +L + + L+ + F+ Q LQ K VED+
Sbjct: 193 DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ----LQSK---VEDEQT 245
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q Q + + LEE+I+A A++ + + + E+L +++
Sbjct: 246 LGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST 305
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
+ + E + L LE+ + + ++A + + + + +I +
Sbjct: 306 QIELNKKREAEFLKLRRDLEEATLQH-EAMVATLRKKHADSVAE---LGEQIDNLQRVKQ 361
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+E E S++K I L S+ + + +LE+ L L E + E EL
Sbjct: 362 KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTT 421
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL--VEKA 883
+ + L + +QL E E +L + Q ++ + L+ L + + NAL ++
Sbjct: 422 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALGHALQS 481
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
+R D + +Y+ + ++ ++ L+R + + + Q + + E I+ ++E A +
Sbjct: 482 SRHD-CDLLREQYEEE-QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 539
Query: 944 KVLNEKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ E+ +E V LE Q + +E+L ++VE N + L K+Q
Sbjct: 540 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL-----DKKQRN 594
Query: 1000 SPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
++ + + A L+ +E +L+ ++ + +Y + E+ + +N
Sbjct: 595 FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET----VKRENKN 650
Query: 1060 MEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE 1119
+E+E+ +++Q+ ++ + EL+ ++ + + +++ E + E I+ +E
Sbjct: 651 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 710
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLE 1179
++ + +D LK + +S L + + N ++ L
Sbjct: 711 -LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDLN 769
Query: 1180 TLNTELTGHDVVNQEQINQLKS---KLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+ +L+ + E + L+S +L+ D+ L +L+ + + V++R A
Sbjct: 770 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL-AIVERR----A 824
Query: 1237 ELWKQHLAQREADFQKTE--HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTS 1294
L + + + A ++TE +L Q ++ QLL + +S K+ T +
Sbjct: 825 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET--DLMQ 882
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
LQ++++D RN +EK I ++ E++ E+
Sbjct: 883 LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 919
Score = 93.1 bits (221), Expect = 8e-18
Identities = 195/1019 (19%), Positives = 426/1019 (41%), Gaps = 104/1019 (10%)
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPS 303
++KD ++ E K LE + E + L +++ L K +
Sbjct: 4 KTKD-ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLE 62
Query: 304 CEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPS 363
+ K E+ E+ E ELT K LE ++++ +LE LA + E A +
Sbjct: 63 AKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 121
Query: 364 KKGSPLIS------RKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
K + +S K R + ++ L +D +NK + +KLE ++ L
Sbjct: 122 KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK-SKLEQQVEDL 180
Query: 418 NKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLI----AQLQLEHQQHMEGPSLIHVGTNT 472
L +K+ + + +++++ + QL+ + + + +
Sbjct: 181 ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 240
Query: 473 EDVNEIA-KVQEQLK------QELNDEIK-DVNVKDLIEKLKS-AEEQITQLNDEI-DAA 522
ED + + Q+++K +EL +EI+ + + EK +S ++ +L++ + +A
Sbjct: 241 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 300
Query: 523 NKNMIKVKSNHK-----LKLKQ--MQKTIDNFSKVSDSNKE----IVRLTEELHHLSQKV 571
+++ N K LKL++ + T+ + + V+ K+ + L E++ +L +
Sbjct: 301 GVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVK 360
Query: 572 AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM-----ENLAETRLK------AISLLE 620
+LE+EK +L + D S S + ++ + L+E R K ++S L
Sbjct: 361 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 420
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
+QK L E L + ++E+K + +SQL + ++ L+ Q++ + +K L
Sbjct: 421 TQKSRLQTEAGELSR---QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALGH 477
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+++ + D + L ++ + K ++ L E K E + ++ EL
Sbjct: 478 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL----- 532
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
EE K Q ++Q+ + +E + ++ + + RL+ + ED +ER A+
Sbjct: 533 -EEAKKKLAQ-----RLQDSEEQVEAVNAKCASLEKTKQRLQGEV---EDLMVDVER-AN 582
Query: 801 QLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
L + L +KQ K +E+ + +E L + R + +L ++++ +E + +
Sbjct: 583 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE 642
Query: 857 ILLEENQNLQISLSDMQQHY----NALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
+ EN+NL+ ++D+ + + E E E Q L + E+ L+ H
Sbjct: 643 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE---H 699
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-TQLEAQLQEYKNNI 971
E + I++ + E+ ++ E + +I + + L Y++ +E + + L+A+++ I
Sbjct: 700 E-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAI 758
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+LN++ ++L H +Q ++ + ++ L ++ + +
Sbjct: 759 RLKKKMEGDLNEIEIQL--SHANRQAAETLKHLRSVQGQLKDTQLHL----DDALRGQED 812
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ + ++++ + LE E + ++LLDS NE +Q+L Q
Sbjct: 813 LKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS---NERVQLL----HTQ 865
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
L TK E T+ M + S +E S DA N + + + ++E
Sbjct: 866 NTSLIHTKKKLE-----TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE-- 918
Query: 1152 QERSV-LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
Q+ S L+ L +++ ++ + E L L G ++QI +L++++ +L E
Sbjct: 919 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--ALKG----GKKQIQKLETRIRELEFE 971
Score = 87.0 bits (206), Expect = 5e-16
Identities = 165/828 (19%), Positives = 335/828 (40%), Gaps = 94/828 (11%)
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
E K K + + E +E++ +L ++ + L +Q + + + + D+L+
Sbjct: 1 EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 60
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
L + V ++ + E N EL K + L +E L+ + D++ A VEK
Sbjct: 61 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL-AKVEKEKHA--T 117
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
E++ +L L+ + ++T E + L ++ ++DL+ E E + K
Sbjct: 118 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE-----EDKVNSLNKTKSK 172
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
E+ +E LE+ L++ K +L N +L +L+L + + + N
Sbjct: 173 LEQQVE---DLESSLEQEKKLRVDLERNKRKLEG-DLKLAQESILDLE-----------N 217
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
+ +L+ LK+KD E L K+ + Q ++ ++ K+ + ++E +EEE++ ++
Sbjct: 218 DKQQLDERLKKKDFEYCQLQSKVEDEQ----TLGLQFQKKIKELQARIEELEEEIE--AE 271
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +K +++ D +EL+E E G + S+ IE
Sbjct: 272 RATRAKTE--------KQRSDYARELEELSERLE-----EAGGVTSTQIE---------- 308
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L+ EE +Q +++ K + E +I L+ + +L
Sbjct: 309 -LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 367
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ +I+ L S +E ++ NL L +S A + E + L +++
Sbjct: 368 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN--EEIQRSLSELTTQKSR 425
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
Q EL QL ES QL S Q+ TQ Q L+ +L+++ + L
Sbjct: 426 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQ----------QTEELKRQLEEENKAKNAL 475
Query: 1310 QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN 1369
+ ++LR + E+E+ +E ++ E +
Sbjct: 476 GHALQSSRHDCDLLREQYEEEQEG--------KAELQRALSKANSEVAQWRTKYETDAIQ 527
Query: 1370 INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL---ELKDSEI-YQKTHEYTI 1425
EE + KK VN A+ LE T Q E++D + ++ +
Sbjct: 528 RTEELEEAKKKLAQRLQDSEEQVEAVN-AKCASLEKTKQRLQGEVEDLMVDVERANSLAA 586
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELA---ILRLKMHENANHYETM--QKES 1480
L ++ F+ V L E++ + E+ E E+ L L ++ + N YE Q E+
Sbjct: 587 ALDKKQRNFDKV---LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET 643
Query: 1481 EIERVKLIEELNVKITESVSLN-KQVAELNKALEE-EVAKTN------EMQTALENQEIE 1532
K +E+ +TE ++ N K + EL K+ ++ E+ K + E + ALE++E +
Sbjct: 644 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 703
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
I+ + E+T +++ + ++ + + Q E + + ++ E+
Sbjct: 704 ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 751
Score = 77.0 bits (181), Expect = 5e-13
Identities = 164/893 (18%), Positives = 365/893 (40%), Gaps = 67/893 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD LQ K++ +T L Q+KI E IE +
Sbjct: 218 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 277
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E + + K+R + E +R LEEA EA
Sbjct: 278 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLR-RDLEEATLQHEA 333
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEE-KGSLEIAN 320
+ +H+ EL + KQ +E E K EI++ S+E +
Sbjct: 334 MVATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEFKLEIDDLSSSMESVS 385
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKSGRN 377
++ L K LE + R N+E++ L+ + T+ S+ + + L ++S +
Sbjct: 386 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 445
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q + E Q ++ KN + + + DL+ ++Y E+
Sbjct: 446 QLSRSKQAFTQQTEELKRQLEEENKAKNALGH-ALQSSRHDCDLLREQY--EEEQEGKAE 502
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
++ +AQ + +++ TE++ E K Q Q+ ++++ VN
Sbjct: 503 LQRALSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN 554
Query: 498 VK-DLIEKLKS-AEEQITQLNDEIDAAN----------KNMIKVKSNHKLKLKQMQKTID 545
K +EK K + ++ L +++ AN +N KV + K K ++ Q ++
Sbjct: 555 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELE 614
Query: 546 NFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY-----DSGRMI-ESDV 598
K S S + E+ +L ++ ++ E NL+ + D ++G+ I E +
Sbjct: 615 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK 674
Query: 599 YKKMIEMENLAETRL---KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV 655
+K IE+E A+ +L +A + LE ++ +++ L Q E++ K+A + D+
Sbjct: 675 SRKQIELEK-ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA-----EKDEE 728
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
++K + SA E+ E ++L K+++ G + ++E + ++
Sbjct: 729 IEQLKRNYQRTVETMQSALDAEVRRANEAIRL-KKKMEGDLNEIEIQLSHANRQAAETLK 787
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESELSK 773
+ +L+ L + + +EQ I + + A+++E +E E
Sbjct: 788 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 847
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
+ + E + ++ + SL +L + L + Q + + + +
Sbjct: 848 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 907
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
++ ++L + + + L++ + L + ++LQ L + +Q L K + + + E
Sbjct: 908 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ----LALKGGKKQIQKLE- 962
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
T+ + +LE K+ T + L + ++ +++L + ++ +R + ++++ K
Sbjct: 963 TRIRELEFELEGEQKKNTESVKGL-RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1021
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYT 1004
Y Q E ++ ++ EL + ++ + V K + ++ D+T
Sbjct: 1022 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 1074
Score = 73.3 bits (172), Expect = 6e-12
Identities = 96/457 (21%), Positives = 208/457 (45%), Gaps = 43/457 (9%)
Query: 468 VGTNTEDVNEIAKVQEQLKQELND-----EIKDVNVKDLIEKLKSAEEQITQLNDEIDAA 522
+ N + ++E+ K ++Q++ E D E + ++ K+ + ++TQ+ EID
Sbjct: 662 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID-- 719
Query: 523 NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
K K + +LK + Q+T++ D+ VR E L +K +E + ++
Sbjct: 720 RKIAEKDEEIEQLK-RNYQRTVETMQSALDAE---VRRANEAIRLKKK---MEGDLNEIE 772
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD---- 638
+ L + + + E+ + + ++ + L +T+L L Q+ DL ++L I++++ +
Sbjct: 773 IQL-SHANRQAAETLKHLRSVQGQ-LKDTQLHLDDALRGQE-DLKEQLAIVERRANLLQA 829
Query: 639 EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
EVE+ A + Q + + +E + + E++ L L + L+ D QL ++D
Sbjct: 830 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 889
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
D + K + I + + ++L+K + A + +++ QT + ++
Sbjct: 890 ASRDARNAEEKAKKAITDAAMMAEELKKEQ-----DTSAHLERMKKNLEQTVKDLQHRLD 944
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
E + + L K +I +LE I +E ++K + L++ ++ E T
Sbjct: 945 EAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTY 998
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
Q +E +R VL D +V+K ++++ ++ ++ +E N ++ QH
Sbjct: 999 QSEE--DRKNVLRLQD-LVDKLQVKVKSYKRQAEEA-----DEQANAHLTKFRKAQH--E 1048
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
L E R D+AES+ K + + RD S+ + + HE +
Sbjct: 1049 LEEAEERADIAESQVNKLRAKTRDFTSS-RMVVHESE 1084
Score = 37.5 bits (83), Expect = 0.40
Identities = 67/352 (19%), Positives = 134/352 (38%), Gaps = 27/352 (7%)
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
+FQKT+ EL + + E+L+ VQ + E + + + +
Sbjct: 1 EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 60
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR---TENQSYKQMQEQ 1365
L+ K +V + E EI E A DL + + K E
Sbjct: 61 LEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 119
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ-KTHEYT 1424
+ N+ EE + L ++ E K L+ HQ L D + + K +
Sbjct: 120 KVKNLTEELSGLDETIAKLT------------REKKALQEAHQQALDDLQAEEDKVNSLN 167
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILR---LKMHENANHYETMQK 1478
T ++ + E++ L + +K DL K E +L + + L + + + K
Sbjct: 168 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 227
Query: 1479 ESEIERVKLIEELNVKITESVSLNKQVAELN---KALEEEVAKTNEMQTALENQEIEIVT 1535
+ + E +L ++ + T + K++ EL + LEEE+ + E Q +
Sbjct: 228 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 287
Query: 1536 LNDEIT-NLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPR 1586
+E++ L+ +S++I+ + ++ + R + + T+ E + A R
Sbjct: 288 ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR 339
>D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heavy
chain protein.
Length = 1052
Score = 115 bits (277), Expect = 1e-24
Identities = 177/979 (18%), Positives = 404/979 (41%), Gaps = 48/979 (4%)
Query: 140 QLGDVTH-LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+L ++ H + ++E+++ LQ + K M +LDL+E++ E+++ K +
Sbjct: 33 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-EEEEAARQKLQLEKVTAE 91
Query: 199 XXXXXXXXXXXXXEDTKQQMTK----MQENF--IAMEAEWKDEKQRLLKDIESK-DVRIS 251
+D +++K ++E + ++EK + L +++K + IS
Sbjct: 92 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 151
Query: 252 SLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
LE K E +R E+ KL + L Q + E + +
Sbjct: 152 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 211
Query: 312 EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS 371
EIA KKI LE I ++L+++ A +KA G L +
Sbjct: 212 RLDD-EIAQKNNALKKIRELEG---HISDLQEDLDSERAA---RNKAEKQKRDLGEELEA 264
Query: 372 RKSGRNTASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLN-KDLVDKEYVIS 429
K+ + +L ++ + T KK E E +Q + K E +
Sbjct: 265 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 324
Query: 430 EKDTXXXXXXXXXXGKDTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ + K TL + L + + G + V + + A+VQE +
Sbjct: 325 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--AQVQELQSKC 382
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DN 546
+ E + D + KL++ E +T + +E + + K ++ +L+ Q+ + +
Sbjct: 383 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 442
Query: 547 FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME 606
K++ S K + +L EE + L ++ E E K NL+ H+ + + SD KK+ +
Sbjct: 443 RQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFA 498
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E + + + +L Q+ YD++E + Q D V L
Sbjct: 499 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 558
Query: 667 QIDALSASKKELALVIENLKL----DKEQLYGTIKDLENDKEDIMNKLQNYIQ--ENMDL 720
++ +L +N+ ++++ ++ E + L+ ++ E ++
Sbjct: 559 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 618
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T+K+ K E + + +++ ++ +++E +E +E EL + R
Sbjct: 619 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQASEDAKLR 678
Query: 781 LEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
LE ++ ++ + L+ + +Q ++ Q+ EY + ++ N A+ + +E
Sbjct: 679 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERNERALAAAAKKKLEG 738
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
L ++E + K + +++ + LQ + D Q+ +A+R ++ + + + + +
Sbjct: 739 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA--RASRDEIFAT-AKENEKK 795
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ LE++L ++ + ++ ++ DLE E ++ S++ + L ++ + +
Sbjct: 796 AKSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 853
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
QLE +L+E + N+E ++ V + + +L ++ ++ T + E ++ + N L
Sbjct: 854 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN--ESARQQLERQNKEL 911
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+ K L++ + + S ++ E+K+AQ ++E E Q +K L +
Sbjct: 912 RSK------LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 965
Query: 1079 EELQILVREQDDQIKELKE 1097
+E+ + V ++ ++ KE
Sbjct: 966 KEILLQVEDERKMAEQYKE 984
Score = 115 bits (276), Expect = 2e-24
Identities = 192/1058 (18%), Positives = 443/1058 (41%), Gaps = 78/1058 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
++ Q T++ M +KQ L + + + R+ E+ + L+A R +++ +
Sbjct: 7 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 66
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELL 331
L ++LE+ L K + E ++ +E++ + +L+K+ +LL
Sbjct: 67 LDLEEQLEEEEAARQKLQ-----LEKVTAEAKIKK---LEDEILVMDDQNNKLSKERKLL 118
Query: 332 EHLNCQIRQTNKELENKLATMGT-ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
E + E E K + ++K S S+ L + R K+K +
Sbjct: 119 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 178
Query: 391 SETLNQDTDKKIN----KNEIAKLEMVIQS----LNKDLVDKEYVISEKDTXXXXXXXXX 442
S+ Q D + K ++AK E +Q+ L+ ++ K + +
Sbjct: 179 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 238
Query: 443 XGKDT-LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDL 501
D+ A+ + E Q+ G L + T ED + Q++L+ + E+ V K L
Sbjct: 239 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT-VLKKAL 297
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRL 560
E+ +S E Q+ ++ + A + + + +L+Q ++ N K + KE L
Sbjct: 298 DEETRSHEAQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENADL 350
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLKAI 616
EL L Q E+E +K L+ + + S G +++ K+ +++N E+ +
Sbjct: 351 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 410
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDAL 671
+ E + L +++ L + + ++ L + ++ Q V ++++ + L++Q+D
Sbjct: 411 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEE 469
Query: 672 SASKKELALVIENLKLD----KEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMDLT 721
+K+ L I L + K++L T++ LE K+ +++N Q E
Sbjct: 470 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 529
Query: 722 DKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL 781
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY R
Sbjct: 530 DKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 588
Query: 782 EESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVLMDHD 834
E E + SL R ++ +E ++ + ++LV+ + L
Sbjct: 589 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 648
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E +
Sbjct: 649 RALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEKRR 706
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
+ Q QL + E+ L+ +E KKK DL+ + Q +SAI+ + E+ I
Sbjct: 707 QLQRQLHEYETELEDERNERALAAAAKKKLEGDLK-DLELQADSAIKGR-------EEAI 758
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + +L+AQ+++++ +E+ + +E+ ++ +K ++ D Q ++
Sbjct: 759 KQLRKLQAQMKDFQRELEDARASRDEI----FATAKENEKKAKSLEADLM-QLQEDLAAA 813
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRVSKQL 1071
KQ D E L +++ ++ ++ + E+++AQ +LE + M+ +S ++
Sbjct: 814 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 873
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+ Q E+L + + ++ + + E + + S + M +
Sbjct: 874 RKATQQAEQLSNELATERSTAQKNESARQQLER-----QNKELRSKLHEMEGAVKSKFKS 928
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
++ E+ +E+ + + + +L+E ++ + +
Sbjct: 929 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 988
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ QLK +LE+ E+ + + +L+ + A +
Sbjct: 989 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1026
Score = 114 bits (275), Expect = 2e-24
Identities = 197/976 (20%), Positives = 418/976 (42%), Gaps = 91/976 (9%)
Query: 626 LVQELHILQQKYDEVEDKLADIS--QLQSDQVCSEIKSVHLEEQIDA---LSASKKELAL 680
L ++L + Y E E+ ++ + + +++ E+++ LEE+ D L A +K++A
Sbjct: 6 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA-RLEEEEDRGQQLQAERKKMAQ 64
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
+ +L+ E+ + L+ +K K++ E + + D+ K+S E+ K+
Sbjct: 65 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER------KLL 118
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E S + T + E + +N+ +K++S I LE + E R LE+
Sbjct: 119 EERISDLTTN------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 172
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+L + + ++ Q EL +LA + E+ + + E+ +KN L +
Sbjct: 173 KLEGDASDFHEQIADLQAQIAELKMQLA------KKEEELQAALARLDDEIAQKNNAL-K 225
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRI---THEHQTL 917
+ + L+ +SD+Q+ ++ E+A R AE + +L L++ L+ T Q L
Sbjct: 226 KIRELEGHISDLQEDLDS--ERAARNK-AEKQKRDLGEELEALKTELEDTLDSTATQQEL 282
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
++++E+ L+ + + S + + +K+ + +E +T+ QL+++K NL+ N
Sbjct: 283 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE---QLEQFKRAKANLDKN 339
Query: 978 VEELNKMNLELI-DKHVQKQQTQSPDYTEQYIN-EINKLNALLKQKDEEIIALNQKINNA 1035
+ L K N +L + V Q Q ++ ++ + ++ +L + + LN K++
Sbjct: 340 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 399
Query: 1036 Q---VSYMSMVSDYESK-------LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
Q S M+++ E K +A +++L++ +E +Q ++Q L+ +L+
Sbjct: 400 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 459
Query: 1086 REQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ 1145
DQ+ E E K E +I T + +S + + + D A+ V+ +++
Sbjct: 460 NSLQDQLDEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEEGKKRFQK--EIE 516
Query: 1146 EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ 1205
+ +E++ ++ K LQ+ +L+ L VV+ + QL S LE+
Sbjct: 517 NLTQQYEEKAAAYDKLEKTKNRLQQ------ELDDL--------VVDLDNQRQLVSNLEK 562
Query: 1206 LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFE 1265
+ D LL AE ++ S D+R AE RE + K R A E
Sbjct: 563 KQRKFDQLL---AEEKNISSKYADERDRAEAE-------AREKE-TKALSLARALEEALE 611
Query: 1266 SKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
+K E L+ + E +V+ + + + + E+ R L+ + ++ Q+E L
Sbjct: 612 AKEE--LERTNKMLKAEMEDLVSSKD--DVGKNVHELEKSKRALETQMEEMKTQLEELED 667
Query: 1326 EIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXX 1385
E++ + A DL+ ++ ++ + Q ++E +L+
Sbjct: 668 ELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE--DERNE 725
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKD-SEIYQKTHEYTITLTQRNDEFENVRQQLVEY 1444
+ + + K LEL +K E ++ + + E E+ R E
Sbjct: 726 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 785
Query: 1445 EKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQ 1504
++ +K L +++ E+ E +K++++E+ +L EEL S+S
Sbjct: 786 FATAKE-NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL----ASSLSGRNA 840
Query: 1505 VAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDT 1564
+ + + LE +A +++ LE ++ + ++D + S+++ S A
Sbjct: 841 LQDEKRRLEARIA---QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 897
Query: 1565 KQGRDEQLDNTMNKEL 1580
+ R +QL+ NKEL
Sbjct: 898 ESAR-QQLER-QNKEL 911
Score = 114 bits (274), Expect = 3e-24
Identities = 207/1051 (19%), Positives = 448/1051 (42%), Gaps = 91/1051 (8%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
KQ++ ++ A E +D Q+L + + ++ LEE + EAAR ++ LE
Sbjct: 31 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 90
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHL 334
++++ L+K E+ +EE+ S N+ E +K + L L
Sbjct: 91 EAKIKKLEDEILVMDDQNNKLSK--------ERKLLEERISDLTTNLAEEEEKAKNLTKL 142
Query: 335 NCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETL 394
+ ELE +L E K S++ + RK AS + L ++
Sbjct: 143 KNKHESMISELEVRLK---KEEK-----SRQELEKLKRKL-EGDASDFHEQIADLQAQI- 192
Query: 395 NQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDT-LIAQLQ 453
+ ++ K E +L+ + L+ ++ K + + D+ A+ +
Sbjct: 193 -AELKMQLAKKE-EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 250
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT 513
E Q+ G L + T ED + Q++L+ + E+ V K L E+ +S E Q+
Sbjct: 251 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV-TVLKKALDEETRSHEAQVQ 309
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVA 572
++ + A + + + +L+Q ++ N K + KE L EL L Q
Sbjct: 310 EMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 362
Query: 573 ELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
E+E +K L+ + + S G +++ K+ +++N E+ ++ E + L +
Sbjct: 363 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 422
Query: 629 ELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDALSASKKELALVIE 683
++ L + + ++ L + ++ Q V ++++ + L++Q+D +K+ L I
Sbjct: 423 DVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 481
Query: 684 NLKL----DKEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMDLTDKLEKMSAEKIS 733
L + K++L T++ LE K+ +++N Q E DKLEK + ++
Sbjct: 482 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK-TKNRLQ 540
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+ L + + ++ Q ++ K ++ D + ++ SKY R E E +
Sbjct: 541 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 600
Query: 794 SLERKADQLGSYLQEKQ------KAYSEYTI-QEDELVNRLAVLMDHDRVVEKQLLEIEH 846
SL R ++ +E + KA E + +D++ + L R +E Q+ E++
Sbjct: 601 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 660
Query: 847 ENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN 906
+ +EL+ + Q + L++++ ++ + ++ R + E + + Q QL + E+
Sbjct: 661 QLEELEDELQASEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEKRRQLQRQLHEYETE 718
Query: 907 LKRITHEHQTLIVQKKK---EIEDLEIEFNTQI---ESAIRDKKVLN---EKYEKNIEYV 957
L+ +E KKK +++DLE++ ++ I E AI+ + L + +++ +E
Sbjct: 719 LEDERNERALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 778
Query: 958 ----TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
++ A +E + ++L ++ +L + +L ++ ++ + + E+ + ++
Sbjct: 779 RASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERARKQADLEKEELAEELASSLSG 837
Query: 1014 LNALLKQK---DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
NAL +K + I L +++ Q M +SD K Q +L N E +R + Q
Sbjct: 838 RNALQDEKRRLEARIAQLEEELEEEQ-GNMEAMSDRVRKATQQAEQLSN-ELATERSTAQ 895
Query: 1071 LLDS-----KQHNEELQILVREQDDQIK-ELKETKLTFEMNIPKTEGMIISSTIEPMSDD 1124
+S ++ N+EL+ + E + +K + K T E I + E + E
Sbjct: 896 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ---EAREKQ 952
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTE 1184
A L+V++E + ++ +EQ+ K N +++ ++ + E +
Sbjct: 953 AATKSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQLKRQLEEAEEESQR 1009
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+ + Q ++++ E + E + L S
Sbjct: 1010 INANRRKLQRELDEATESNEAMGREVNALKS 1040
Score = 87.8 bits (208), Expect = 3e-16
Identities = 176/913 (19%), Positives = 375/913 (41%), Gaps = 83/913 (9%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXX 196
++ D+T +N +E++ A ++ ++K K E+ I +L+ ++ +++ Q +E +
Sbjct: 121 RISDLT--TNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEGD 177
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSL 253
+ K Q+ K +E A A DE K LK I + IS L
Sbjct: 178 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 237
Query: 254 EEANKLLEAARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQS-----IEPSC 304
+E AAR + + L +ELE + AK+ ++ +
Sbjct: 238 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 297
Query: 305 EEKT-----EIEEKGSLEIANMTELTKKIELLEHLNCQI---RQT----NKELENKLATM 352
+E+T +++E + ELT+++E + + +QT N +L +L +
Sbjct: 298 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 357
Query: 353 GTESKAVSSPSKKGSPLISR-----KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
G + V KK + G +++ +L +E + + +
Sbjct: 358 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 417
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
KL + SL+ L D + ++ E+ + LQ + + ME +
Sbjct: 418 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 477
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNM 526
+T ++ K++L D V + +K E E +TQ +E AA +
Sbjct: 478 RHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 532
Query: 527 IKVKSNHKLKLKQMQKTIDN----FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
K K+ + +L + +DN S + ++ +L E ++S K A+ E+ +
Sbjct: 533 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD---ERDRAE 589
Query: 583 LHLVDYDSGRMIESDVYKKMIEM-ENLAETR--LKA-ISLLESQKFDLVQELHILQQKYD 638
+ ++ + + ++ +E E L T LKA + L S K D+ + +H L++
Sbjct: 590 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 649
Query: 639 EVEDKLAD----ISQLQSDQVCSEIKSVHLEEQIDALSAS-KKELALVIENLKLDKEQLY 693
+E ++ + + +L+ + SE + LE + AL +++L E + + QL
Sbjct: 650 ALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 709
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ-SKIQTQFG 752
+ + E + ED N+ L L+ + + S + + +Q K+Q Q
Sbjct: 710 RQLHEYETELEDERNERALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 769
Query: 753 I------DAKIQERDLYIENIESE--LSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
DA+ +++ E+E ++ + +L+E +A E R + + ++L
Sbjct: 770 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 829
Query: 805 YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
L + ++ L R+A L + +E++ +E + ++K Q + +
Sbjct: 830 ELASSLSGRNALQDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNE 886
Query: 865 LQISLSDMQQHYNAL--VEKAN---RTDLAESES---TKYQTQLRDLESNLKRITHEHQT 916
L S Q++ +A +E+ N R+ L E E +K+++ + LE+ + ++ + +
Sbjct: 887 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 946
Query: 917 LIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQEYKNN 970
+K+ + L+ + +I + D++ + E+Y++ E V QL+ QL+E +
Sbjct: 947 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1006
Query: 971 IENLNMNVEELNK 983
+ +N N +L +
Sbjct: 1007 SQRINANRRKLQR 1019
Score = 79.4 bits (187), Expect = 1e-13
Identities = 128/640 (20%), Positives = 271/640 (42%), Gaps = 47/640 (7%)
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLE 332
KLA+++ +Q + S + + EE+ SL+ E+ K L
Sbjct: 419 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 478
Query: 333 H---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMKSPWSQ 388
H LN Q+ + K+L++ +T+ + K+ L + + A K++ ++
Sbjct: 479 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 538
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
L E + D + ++ LE + ++ L +++ + S+ K+T
Sbjct: 539 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 598
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVNVKD-----LI 502
L ++ +E + E N++ K + E L +D K+V+ + L
Sbjct: 599 ALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 652
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
+++ + Q+ +L DE+ A+ ++++ N + Q ++ + + ++ + +L
Sbjct: 653 TQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQR 710
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLL 619
+LH ELE+E+ L + + +E D+ ++ ++ + R +K + L
Sbjct: 711 QLHEYE---TELEDERNERALAAA---AKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 764
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
++Q D +EL + DE+ A + + E + L+E + A ++K+
Sbjct: 765 QAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 821
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTDKLEKMS--AE 730
L E L + L+++K + + +L+ ++E NM+ ++D++ K + AE
Sbjct: 822 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 881
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVME 789
++S LA Q + ++ + +E + +E + SK+KS I LE IA +E
Sbjct: 882 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 941
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HDRV--VEKQLL 842
++ R+ L++K K E +Q EDE + + + + RV +++QL
Sbjct: 942 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1001
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
E E E++ + + L E S M + NAL K
Sbjct: 1002 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1041
>AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain protein.
Length = 1938
Score = 114 bits (275), Expect = 2e-24
Identities = 223/1107 (20%), Positives = 467/1107 (42%), Gaps = 102/1107 (9%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEEL-------HHLSQKVAELEEEKGNLQLHLVDY 588
K+K + K+ + +++ ++ R EEL L +K+ L +EK +LQL +
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAIS--LLESQKF--DLVQELHILQQKYD----EV 640
M + + +I+ + L E ++K ++ L E ++ +LV + L+ K ++
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 641 EDKLADISQLQSDQVCSE--IKSVH-----LEEQIDALSASKKEL----ALVIENLKLDK 689
+D +++++ ++ +E +K++ LEE I L+ KK L +++L++++
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 690 EQLYGTIK---DLENDKEDIMNKLQNYIQENMDL---TDKLE---KMSAEKISELLAKIN 740
+++ G IK LE +D+ L+ + DL KLE KMS E I +L +
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQ 1078
Query: 741 HEEQSKIQTQF---GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
E+ + +F + A+I + ++ + ++ + ++RI LEE I R +E+
Sbjct: 1079 QIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Query: 798 KADQLGSYLQE----KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
+ L L+E ++A + Q + R A R +E+ L+ E L+K
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 854 KN----QILLEENQNLQISLSDMQQHYNALVEK-----ANRTDLAESESTKYQT--QLRD 902
K L E+ NLQ +++ + L + +N L++S+S +T + D
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 903 LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ--- 959
S +K + LI + L+ + N ++ + +K+ L + K+ + +TQ
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQ-NGELSHRVEEKESLISQLTKSKQALTQQLE 1317
Query: 960 -LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L+ Q++E + +N + + ++ + +L+ + +++Q + ++ +++ N A
Sbjct: 1318 ELKRQMEE-ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE-LQRALSKANSEVAQW 1375
Query: 1019 KQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
K K E + I +++ A+ + + E K +K ++E+ QR+ ++ D +
Sbjct: 1376 KTKYETDAIQRTEELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E D + + + ++ + +++ + ++ E S
Sbjct: 1436 LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 1138 XXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQI 1196
++ E + +QE S L EQ A+ LQE +E ++L Q +
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDL-------QVAL 1548
Query: 1197 NQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHE 1256
+++ LE ++ + +++++S + V ++ EI +L + EA + E
Sbjct: 1549 EEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAE 1608
Query: 1257 LRVQLSA--FESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQNKLQDKEEHL------- 1306
+R + A + K E L+ ++ ++ T + ++Q +L+D + HL
Sbjct: 1609 IRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALRSN 1668
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAF--XXXXXXXXXXXXXXXXD----LRTENQSYK 1360
+L+E+ A V + +L E+E+ KVA D L ++N S
Sbjct: 1669 EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLI 1728
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQK 1419
+++ +I + A+++ S + DA EL + + E +K
Sbjct: 1729 NTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 1420 THEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYE-----KESELAILRLKMHE 1468
E T+ L R DE E + ++Q+ + E R+ +L E K A+ +E
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYE 1848
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
T Q E + + + +++L K+ V K+ AE EE A T +
Sbjct: 1849 RKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAE----EAEEQANTQLSRCRRVQ 1904
Query: 1529 QEIEIVTLNDEITNLQ-NMVRASSSKI 1554
E+E +I Q N +RA S +
Sbjct: 1905 HELEEAAERADIAESQVNKLRAKSRDV 1931
Score = 109 bits (262), Expect = 8e-23
Identities = 207/1117 (18%), Positives = 448/1117 (40%), Gaps = 71/1117 (6%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + +D E ++ E K LE + E + L +++
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I + K E+ E+ E +EL K LE +++ +LE L
Sbjct: 907 ERCEGLIKSKILLEAKVK-ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 350 ATMGTESKAVSSPSKKGSP-LISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIA 408
+ E A + K S + + + + +K K + +TL+ D ++ ++++
Sbjct: 966 TKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLD---DLQVEEDKVN 1022
Query: 409 KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
L + L + D E + ++ D A+ +LE M S++ +
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLRA---------DLERAKRKLEGDLKMSQESIMDL 1073
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI--EKLKSAEEQITQLNDEIDAANKNM 526
+ + E K +E +L I D V L +K+K + +I +L +EI+A +
Sbjct: 1074 ENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
K++ +++++ + + S + + + ++ QK+ + E+ LQ H
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRR-DLEEATLQ-HEA 1191
Query: 587 DYDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ R ++D ++ E ++NL + K LE +K +L E ++D +
Sbjct: 1192 TAATLRKKQADSVAELGEQIDNLQRVKQK----LEKEKSELKME----------IDDMAS 1237
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
+I L + E +E+Q + A ++ +I +L + K +L +L + E+
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
+ + + LT +LE EL ++ E ++K + + + DL E
Sbjct: 1298 KESLISQLTKSKQALTQQLE--------ELKRQMEEETKAKNAMAHALQSSRHDCDLLRE 1349
Query: 766 NIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
E E + K+ + R L ++ + + + E A Q L+E +K ++ +QE E
Sbjct: 1350 QYEEE-QEAKAELQRALSKANSEVAQWKTKYETDAIQRTEELEEAKKKLAQ-RLQEAE-- 1405
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN-ALVEKA 883
+ +EK ++ E ++L + LE + +L Q++++ L E
Sbjct: 1406 EKTETANSKCASLEKTKQRLQGEVEDLMRD----LERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQIESAI 940
+ D +++E Q + R L + L ++ + ++ ++ Q ++E ++L+ E + E
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 941 RDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE-NLNMNVEELNKMNLEL--IDKHVQKQQ 997
K L E EK + V Q ++ LQ +E +L ++ ++ LEL + + ++
Sbjct: 1522 ETGKNLQEA-EKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV 1580
Query: 998 TQSPDYTEQY-INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+ + EQ N AL D EI + N + + +++ E +L +
Sbjct: 1581 IEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL-RLKKKMEGDLNEMEIQLGHSNRQ 1639
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
+ + ++ V QL DS+ H L +R +D ++L + + + + E M ++
Sbjct: 1640 MAETQRHLRTVQGQLKDSQLH---LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVA- 1695
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+E ++ + L + I + L+ A+ E++ +
Sbjct: 1696 -LE-QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
E + + E++ + + L NL TV +L+ + A +Q +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-EQLALKGG 1812
Query: 1237 ELWKQHLAQREADFQK---TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-V 1292
+ Q L R + + E + + KYE+ + + +E+ I+ ++ V
Sbjct: 1813 KKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDRKNILRLQDLV 1872
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
LQ K++ + +E+ +++ ++ E+E+
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEE 1909
Score = 105 bits (252), Expect = 1e-21
Identities = 167/777 (21%), Positives = 340/777 (43%), Gaps = 76/777 (9%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI-------SLS 870
++ E +A + + +++L E KEL++K LL+E +LQ+ +L
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 871 DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
D ++ L++ + E T+ + ++ S L + K++I+DLE+
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 931 EFNTQIES---AIRDK-KVLNEK---YEKNIEYVTQLEAQLQE-YKNNIENLNMNVEELN 982
T++E A +K K L+E+ E+NI +T+ + LQE ++ +++L + +++N
Sbjct: 964 TL-TKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 983 ---KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
K+N +L +QQT D E + + KL A L++ + L + +Q S
Sbjct: 1023 GLIKINAKL------EQQT---DDLEGSLEQEKKLRADLERAKRK---LEGDLKMSQESI 1070
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK--- 1096
M D E++ Q KL+ E E+ ++ ++ D + H+ + Q ++E +I+EL+
Sbjct: 1071 M----DLENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEI 1126
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
E + T I K + ++ +E +S+ + + E EF + R
Sbjct: 1127 EAEHTLRAKIEK-QRSDLARELEEISERLEE----ASGATSAQIEMNKKREAEFQKMRRD 1181
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS 1215
L+E A L E + Q +++ EL G + N +++ Q L+ + +L E D++ S
Sbjct: 1182 LEE--ATLQHEATAATLRKKQADSV-AEL-GEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+ L S S +++ + + + + A+ E Q H+L +Q + +++ +L V
Sbjct: 1238 NIEALSKS-KSNIERTCRTVEDQFSEIKAKDEQQTQLI-HDLNMQKARLQTQNGELSHRV 1295
Query: 1276 QSS----TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ +Q +K +Q+ L+ +++++ + + + ++LR + E+E+
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQ 1355
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
A +E +K E + EE + KK
Sbjct: 1356 EA--------KAELQRALSKANSEVAQWKTKYETDAIQRTEELEEAKKKLAQRLQEAEEK 1407
Query: 1392 XXRVNDAEAKVLELTHQL--ELKD-SEIYQKTHEYTITLTQRNDEFENV----RQQLVEY 1444
N A + + +L E++D +++H TL ++ F+ V +Q+L E
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467
Query: 1445 EKRIEDLTYEKES---ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
+ +E E S EL +R E + ET+++E++ + I +L +I E+
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENK-NLQEEISDLTEQIAET-GK 1525
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
N Q AE K L E+ + +++Q ALE E + +I +Q + S++ + V
Sbjct: 1526 NLQEAEKTKKLVEQ--EKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV 1580
Score = 77.8 bits (183), Expect = 3e-13
Identities = 153/781 (19%), Positives = 326/781 (41%), Gaps = 71/781 (9%)
Query: 148 SNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXX 207
++++ E + LQ + +E +L+ +I++ IEA +K+ +
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
+QQ T++ + +A + + L +E K+ IS L ++ + L E+
Sbjct: 1261 SEIKAKDEQQ-TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL 1319
Query: 268 SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE---KGSLEIANM--- 321
+ + + + L ++ E E K E++ K + E+A
Sbjct: 1320 KRQMEE-ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWKTK 1378
Query: 322 --TELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA 379
T+ ++ E LE ++ Q +E E K T SK S K R G
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEEKTET--ANSKCASLEKTK-----QRLQGEVED 1431
Query: 380 SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
S + TL DKK +N L Q L++ + E E +
Sbjct: 1432 LMRDLERSHTACATL----DKK-QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELF 1486
Query: 440 XXXXGKDTLIAQLQL---EHQQHMEGPS-----LIHVGTNTEDVNEIAKVQEQLKQELND 491
+ ++ QL+ E++ E S + G N ++ + K+ EQ K +L
Sbjct: 1487 KMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQV 1546
Query: 492 EIKDV--NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK 549
+++V +++ K+ + +++Q+ E+D K + K + +LK + Q+ +
Sbjct: 1547 ALEEVEGSLEHEESKILRVQLELSQVKSELD--RKVIEKDEEIEQLK-RNSQRAAEALQS 1603
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
V D+ +R + L +K +E + +++ L + + +M E+ + + ++ + L
Sbjct: 1604 VLDAE---IRSRNDALRLKKK---MEGDLNEMEIQL-GHSNRQMAETQRHLRTVQGQ-LK 1655
Query: 610 ETRLKAISLLESQKFDLVQELHILQQK----YDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+++L L S + DL ++L I++++ +E+E+ + Q + + SE + +
Sbjct: 1656 DSQLHLDDALRSNE-DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDAS 1714
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
+++ L + L + L+ D Q +++ + + K + I + + ++L+
Sbjct: 1715 DRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELK 1774
Query: 726 KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
K + + L + EQ+ Q +D + L ++ + ++ K ++R+ LE +
Sbjct: 1775 K-EQDTSAHLERMKKNLEQTVKDLQHRLD---EAEQLALKGGKKQIQKLENRVRELENEL 1830
Query: 786 AVMEDRRYSLERKADQL-GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
V + +R A+ L G++ E++ Y +ED R +L D +V+K ++
Sbjct: 1831 DVEQ------KRGAEALKGAHKYERKVKEMTYQAEED----RKNILRLQD-LVDKLQAKV 1879
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
+ ++ ++ EE N Q+S QH L E A R D+AES+ K + + RD+
Sbjct: 1880 KSYKRQAEEA-----EEQANTQLSRCRRVQH--ELEEAAERADIAESQVNKLRAKSRDVG 1932
Query: 905 S 905
S
Sbjct: 1933 S 1933
Score = 72.5 bits (170), Expect = 1e-11
Identities = 180/899 (20%), Positives = 363/899 (40%), Gaps = 81/899 (9%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ +K+K+ LS LQ ++ + L Q+KI E IE +
Sbjct: 1080 IEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139
Query: 207 XXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFE 266
+ ++ +++E A A+ + K+R + E + +R LEEA EA
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKR---EAEFQKMR-RDLEEATLQHEATAAT 1195
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
+ + + EL + K ++ ++ E S +N+ +
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEK-EKSELKMEIDDMASNIEALSKSKSNIERTCR 1254
Query: 327 KIE----LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR--KSGRNTAS 380
+E ++ + Q Q +L + A + T++ +S ++ LIS+ KS +
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ 1314
Query: 381 KMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYV--ISEKDTXXXXX 438
+++ Q+ ET ++ ++ +++ + ++ K + K
Sbjct: 1315 QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQ 1374
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
D + +LE + L TE N E+ KQ L E++D+ +
Sbjct: 1375 WKTKYETDAIQRTEELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQGEVEDL-M 1433
Query: 499 KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEI 557
+DL E+ +D +N KV + K KL + Q ++ K S S + E+
Sbjct: 1434 RDL--------ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL 1485
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM-ENLAETRLKAI 616
++ + ++ L E NLQ + SD+ +++ E +NL E K
Sbjct: 1486 FKMRNAYEEVVDQLETLRRENKNLQEEI----------SDLTEQIAETGKNLQEAE-KTK 1534
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI--KSVHLEEQIDALSAS 674
L+E +K DL L ++ + E K+ + QL+ QV SE+ K + +E+I+ L +
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKILRV-QLELSQVKSELDRKVIEKDEEIEQLKRN 1593
Query: 675 KKELALVIENLKLDKE-----QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+ A ++++ LD E K +E D ++ +L + ++ + L +
Sbjct: 1594 SQRAAEALQSV-LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQG 1652
Query: 730 E-KISELLAKINHEEQSKIQTQFGIDAKIQERD-LYIENIE--SELSKYKSRICRLEESI 785
+ K S+L ++ Q I ++ R+ L +E +E + R RL E
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAI---VERRNGLLLEELEEMKVALEQTERTRRLSEQE 1709
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
+ R L Q S + K+K ++ + E+ N + + + +K + +
Sbjct: 1710 LLDASDRVQLLH--SQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAA 1767
Query: 846 HENKELQKKNQI---LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTK-YQTQLR 901
+EL+K+ L +NL+ ++ D+Q +R D AE + K + Q++
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQ----------HRLDEAEQLALKGGKKQIQ 1817
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI----EYV 957
LE+ ++ + +E L V++K+ E L+ + E +++ E+ KNI + V
Sbjct: 1818 KLENRVRELENE---LDVEQKRGAEALKGAH--KYERKVKEMTYQAEEDRKNILRLQDLV 1872
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+L+A+++ YK E EE L + VQ + ++ + + +++NKL A
Sbjct: 1873 DKLQAKVKSYKRQAE----EAEEQANTQLSRC-RRVQHELEEAAERADIAESQVNKLRA 1926
>M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle
myosin heavy chain (NMHC) mRNA, 3' end. ).
Length = 1247
Score = 113 bits (273), Expect = 4e-24
Identities = 198/1027 (19%), Positives = 432/1027 (42%), Gaps = 65/1027 (6%)
Query: 100 QKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTH-LSNTIKEKDNAL 158
Q +++ EK++ ++L + T + +L ++ H L ++E++
Sbjct: 161 QSQLMAEKLQLQEQLQ---AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERY 217
Query: 159 SVLQVKMKIMETTILDLQEKINEKDQIIEAKN--KATTXXXXXXXXXXXXXXXXXEDTKQ 216
LQ + K M+ I +L+E++ E++ + K TT
Sbjct: 218 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 277
Query: 217 QMTKMQENFIA---MEAEWKDEKQRLLKDIESK-DVRISSLEEANKLLEAARFEISLEHS 272
+ K+ E+ IA ++EK + L +++K + I+ LEE + E R E+
Sbjct: 278 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 337
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLE 332
KL + L K + EE + E A KKI LE
Sbjct: 338 KLEGDSTDLSDQIAELQAQIAEL-KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 396
Query: 333 HLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSE 392
QI + ++LE++ A+ +KA G L + K+ + +L S+
Sbjct: 397 S---QISELQEDLESERAS---RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 450
Query: 393 TLNQDTDKKINKNEIAKL-EMVIQSLN-KDLVDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
+ K E AK E IQ + K E + + + K TL
Sbjct: 451 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 510
Query: 451 QLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKLKSA 508
+ + E L+ G ++E + + Q ++L+ + N+ E + D + KL+
Sbjct: 511 E---RGELANEVKVLLQGGRDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 567
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHH 566
+ +T L + D+ + + K S + +L+ Q+ + +N K+S S K + ++ +E +
Sbjct: 568 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK-LKQVEDEKNS 626
Query: 567 LSQKVAELEEE-KGNLQ-----LHLVDYDSGRMIESDV--YKKMIEMENLAETRLKAISL 618
+++ E EEE K NL+ LH D + +E V + E++ + L+ +S
Sbjct: 627 FREQLEEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 686
Query: 619 LESQKFDLVQELHILQQKYD-EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
+K +L + + E++D L D+ Q C+ K +++ D L A +K
Sbjct: 687 RHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH-QRQSACNLEKK---QKKFDQLLAEEKT 742
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
++ ++++ ++ E + L+ +++ +L ++L K ++ +L++
Sbjct: 743 ISAKYAE---ERDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMS 798
Query: 738 K---INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR-RY 793
+ +++ ++ +++E +E +E EL + RLE ++ M+ +
Sbjct: 799 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 858
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
L+ + +Q ++ + E + EDE R + ++ E L ++E
Sbjct: 859 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSAN 917
Query: 853 KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
K +++ + LQ + D + + +A+R ++ +++ + + +L+ +E+ + ++
Sbjct: 918 KNRDEAIKQLRKLQAQMKDCMRELDDT--RASREEIL-AQAKENEKKLKSMEAEMIQL-Q 973
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
E + K++ + E +I ++ + E+ + + QLE +L+E + N E
Sbjct: 974 EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1033
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+N + L K NL+ ID+ + + ++ NE N L +Q E + L +
Sbjct: 1034 LIN---DRLKKANLQ-IDQ-INADLNLERGHAQK--NE-NARQQLERQNKELKVKLQEME 1085
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
+ Y + ++ E+K+AQ +L+N +E Q KQ+ ++ ++L+ ++ + DD+
Sbjct: 1086 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV---RRTEKKLKDVLLQVDDER 1142
Query: 1093 KELKETK 1099
+ ++ K
Sbjct: 1143 RNAEQYK 1149
Score = 106 bits (255), Expect = 6e-22
Identities = 189/1021 (18%), Positives = 425/1021 (41%), Gaps = 80/1021 (7%)
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA-- 670
L +S E + +EL +++K E++L ++ LQS Q+ +E + L+EQ+ A
Sbjct: 123 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLMEMETLQS-QLMAE--KLQLQEQLQAET 179
Query: 671 ------------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENM 718
L+A K+EL + +L+ E+ + L+ +K+ + +Q ++
Sbjct: 180 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQLE 239
Query: 719 DLTDKLEKMSAEKI-SELLAKINHEEQSKIQTQ---FGIDAKIQERDL--YIENIESELS 772
+ +K+ EK+ +E K EEQ ++ Q + K+ E + + N+ E
Sbjct: 240 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 299
Query: 773 KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
K KS + A++ D L R+ Q + ++K + T D++ A + +
Sbjct: 300 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 359
Query: 833 HDRVVEKQLLEIE----HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
+ K+ E++ +E +KN + L++ + L+ +S++Q+ + E+A+R +
Sbjct: 360 LKMQLAKKEEELQAALARVEEEAAQKN-MALKKIRELESQISELQEDLES--ERASR-NK 415
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
AE + +L L++ L+ + K +++ I T E A + + E
Sbjct: 416 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 475
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQY 1007
+K+ + V +L QL++ K NL + L EL ++ V Q + ++ +
Sbjct: 476 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGGRDSEHKRKK 535
Query: 1008 IN-EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEE 1063
+ ++ +L + + L K+ QV + ++S +SK ++ T +E +
Sbjct: 536 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 595
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+Q + L + + L +++ +D+ +E E I++ ++D
Sbjct: 596 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEEAKHNLEKQIATLHAQVAD 655
Query: 1124 DANNV-DXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ-LETL 1181
+ D K+Q++ E + +R E+ +L++ T++ Q L+ L
Sbjct: 656 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR---HEEKVAAYDKLEKTKTRLQQELDDL 712
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+L H + + + + K +QL E + + AE R + ++ + L +
Sbjct: 713 LVDL-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR- 770
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
A EA QK E E R+ F ++ E L+ S++++ K V +
Sbjct: 771 --ALEEAMEQKAELE-RLN-KQFRTEMEDLM-----SSKDDVGKSV------------HE 809
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
E+ R L+++ ++ Q+E L E++ + A DL+ ++ ++
Sbjct: 810 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 869
Query: 1362 MQEQSILNINEENAQL---KKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
++Q + + E A+L +K + D EA + + ++ +
Sbjct: 870 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL-R 928
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
K + D+ R++++ K E E+E+ +++ E E ++
Sbjct: 929 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM----IQLQEELAAAERAKR 984
Query: 1479 ESEIERVKLIEEL-------NVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
+++ ER +L +E+ + + E L ++A+L + LEEE T + L+ +
Sbjct: 985 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1044
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDL 1591
+I +N ++ NL+ + ++ + + + + ++++ T+ + ++ E +
Sbjct: 1045 QIDQINADL-NLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI 1103
Query: 1592 A 1592
A
Sbjct: 1104 A 1104
Score = 104 bits (249), Expect = 3e-21
Identities = 218/1119 (19%), Positives = 472/1119 (42%), Gaps = 120/1119 (10%)
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
+TL +QL E Q E + TE E +++ +L + E++++ DL ++
Sbjct: 158 ETLQSQLMAEKLQLQE-----QLQAETELCAEAEELRARLTAK-KQELEEI-CHDLEARV 210
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
+ EE+ L E +N+ +++ + + QK KV+ K + +L EE
Sbjct: 211 EEEEERYQHLQAEKKKMQQNIQELEEQLEEEESARQKL--QLEKVTTEAK-LKKLEEEQI 267
Query: 566 HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFD 625
L + +L +EK L+ + ++ + E + K + +++N E + + ++
Sbjct: 268 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 327
Query: 626 LVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
QEL ++K + L+D I++LQ+ +++ EE++ A A +E A +N
Sbjct: 328 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ-KN 386
Query: 685 LKLDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
+ L K +L I +L+ D E ++ DL ++LE + E L + +E
Sbjct: 387 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 446
Query: 744 -QSKIQTQFGI------------DAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+SK + + I +A+IQE +E + +L + K LE++
Sbjct: 447 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 506
Query: 787 VMEDRRYSL--------------ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
+E+ R L E K ++ + LQE Q ++E EL +++ L
Sbjct: 507 TLENERGELANEVKVLLQGGRDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 566
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
V L + + ++ +L K L + Q+ Q L + + +L K + E E
Sbjct: 567 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV---EDE 623
Query: 893 STKYQTQLRDLESNLKR-ITHEHQTL---IVQKKKEIEDLE--IEFNTQIESAI-RDKKV 945
++ QL + E K + + TL + KK++ED +E +++ + +D +
Sbjct: 624 KNSFREQLEEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 683
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDY 1003
L++++E+ + +LE + +++L ++++ + NLE K + +
Sbjct: 684 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 743
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ +Y E ++ A ++K+ + ++L + + A M ++ E QF T++E++
Sbjct: 744 SAKYAEERDRAEAEAREKETKALSLARALEEA----MEQKAELERLNKQFRTEMEDLMSS 799
Query: 1064 MQRVSK---QLLDSK----QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
V K +L SK Q EE++ + E +D+++ ++ KL E+N+ +
Sbjct: 800 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ-FER 858
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
++ + + + ++ + E+E ++RS+ KL +L++ I
Sbjct: 859 DLQGRDEQS---EEKKKQLVRQVREMEAELEDE-RKQRSMAVAARKKLEMDLKDLEAHI- 913
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
D N+ + +K +L +L + + + + + R+S + Q A
Sbjct: 914 ------------DSANKNRDEAIK-QLRKLQAQMKDCMRELDDTRASREEILAQ-----A 955
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK-IVTMEQVTSL 1295
+ ++ L EA+ + + EL A + + +Q D + + K + +E+ L
Sbjct: 956 KENEKKLKSMEAEMIQLQEELAAAERA-KRQAQQERDELADEIANSSGKGALALEEKRRL 1014
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
+ ++ EE L ++ ++IN + ++ ++ +++ DL E
Sbjct: 1015 EARIAQLEEELEE-EQGNTELIND-RLKKANLQIDQI----------------NADLNLE 1056
Query: 1356 NQSYKQMQEQSILNINEENAQLK-KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDS 1414
+ + Q E + + +N +LK K + EAK+ +L QL+ +
Sbjct: 1057 -RGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1115
Query: 1415 EIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK-MHENANHY 1473
E + + T++ + ++V Q+ + + E Y+ +++ A RLK +
Sbjct: 1116 ERQAACKQ--VRRTEK--KLKDVLLQVDDERRNAEQ--YKDQADKASTRLKQLKRQLEEA 1169
Query: 1474 ETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
E + + R KL EL + ++N++V+ L L
Sbjct: 1170 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1208
Score = 103 bits (246), Expect = 7e-21
Identities = 212/1137 (18%), Positives = 476/1137 (41%), Gaps = 121/1137 (10%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
E++ + EE++ ++ ++ AA ++++++ L+ + M + + + + E+ E
Sbjct: 131 EEMMAKEEELVKVREKQLAAENRLMEMET---LQSQLMAEKLQ-LQEQLQAETELCAEAE 186
Query: 563 ELH-HLSQKVAELEEEKGNLQLHLVD----YDSGRMIESDVYKKMIEMENLAETRLKAIS 617
EL L+ K ELEE +L+ + + Y + + + + + E+E E A
Sbjct: 187 ELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQLEEEESARQ 246
Query: 618 LLESQKFDLVQELHILQQKYDEVED---KLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
L+ +K +L L+++ +ED KLA +L D++ ++ EE+ S S
Sbjct: 247 KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE---KSKS 303
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+L E + D E+ + + E KL+ ++ DL+D++ ++ A+ I+E
Sbjct: 304 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG---DSTDLSDQIAELQAQ-IAE 359
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
L ++ +E+ ++ + ++++ ++ I + +S+I L+E + R
Sbjct: 360 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIR----ELESQISELQEDLESERASRNK 415
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
E++ LG L E K E T+ L + + + K+ LE E + E Q +
Sbjct: 416 AEKQKRDLGEEL-EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 474
Query: 855 NQILLEENQNLQISLSDMQQ--HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
++ + +Q ++ ++Q A +EKA +T E+E + +++ L + H
Sbjct: 475 -EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT--LENERGELANEVKVLLQGGRDSEH 531
Query: 913 EHQTLIVQKKKEIEDLEIEFNT--QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + + Q +++L+++FN ++ + + DK K + ++ VT L +Q +
Sbjct: 532 KRKKVEAQ----LQELQVKFNEGERVRTELADKVT---KLQVELDNVTGLLSQSDSKSSK 584
Query: 971 IENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQ 1030
+ +E + EL+ + +Q+ +Q +E N L++++EE
Sbjct: 585 LTKDFSALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEEA---KH 640
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ + + V+D + K+ LE EE +++ K L Q +EE V D
Sbjct: 641 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEK---VAAYD- 696
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+L++TK + + + +++ ++ A N++ ++ EE+
Sbjct: 697 ---KLEKTKTRLQQEL---DDLLVD--LDHQRQSACNLEKKQKKFD------QLLAEEKT 742
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEN 1210
I + E+ + E +E TK + L E + Q ++++E L +
Sbjct: 743 ISAKYA--EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 800
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH---ELRVQLSAFESK 1267
D++ +V EL S A++Q+ E K L + E + Q TE L V L A +++
Sbjct: 801 DDVGKSVHELEKS-KRALEQQ----VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 855
Query: 1268 YEQLLDSVQSSTQEETNKIVTM--EQVTSLQNK-----------------LQDKEEHLRN 1308
+E+ L ++E+ ++V E L+++ L+D E H+ +
Sbjct: 856 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDS 915
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
+ + I Q+ L+++++D EN+ + E ++
Sbjct: 916 ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK-----ENEKKLKSMEAEMI 970
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK---VLELTHQLELKDSEIYQKTHEYTI 1425
+ EE A +++ + ++ K LE +LE + +++ ++ E
Sbjct: 971 QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1030
Query: 1426 TLTQRNDEFENVRQQLVE----------YEKRIEDLTYEKESELAILRLKMHENANHYET 1475
ND + Q+ + + ++ E+ + E + L++K+ E ++
Sbjct: 1031 NTELINDRLKKANLQIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1090
Query: 1476 MQKES----EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
K S E + +L E+L+ + E + KQV K L++ + + ++ + E +
Sbjct: 1091 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1150
Query: 1532 EIVTLNDEITNLQNMV----------RASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ + + L+ + AS K+Q+ + A++T + ++ + NK
Sbjct: 1151 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1207
Score = 69.3 bits (162), Expect = 1e-10
Identities = 124/708 (17%), Positives = 296/708 (41%), Gaps = 45/708 (6%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRIS-SLEEANKLL---EAARFEIS 268
D++ + K++ ++ ++ +E +R+ ++ K ++ L+ LL ++ +++
Sbjct: 528 DSEHKRKKVEAQLQELQVKF-NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 586
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
+ S L +L+ L+ + + E+ + E+ E L K+I
Sbjct: 587 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEEAKHNLEKQI 646
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMKSPWS 387
L + Q+ K++E+ + + T + K L R + A K++ +
Sbjct: 647 ATL---HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKT 703
Query: 388 QLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDT 447
+L E + D + LE + ++ L +++ + ++ K+T
Sbjct: 704 RLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 763
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV--NVKDLIEKL 505
L ++ ME + + N + E+ + K ++ + ++ + + L +++
Sbjct: 764 KALSLARALEEAMEQKAELE-RLNKQFRTEMEDLMSS-KDDVGKSVHELEKSKRALEQQV 821
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK-EIVRLTEEL 564
+ + Q+ +L DE+ A ++++ N + Q ++ + + S+ K ++VR E+
Sbjct: 822 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 881
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
AELE+E+ + + M D+ + + +K + L++Q
Sbjct: 882 E------AELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK 935
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
D ++EL + +E+ LA + + E + + L+E++ A +K++ +
Sbjct: 936 DCMRELDDTRASREEI---LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 992
Query: 685 L--KLDKEQLYGTIKDLENDK-EDIMNKLQNYIQE---NMDL-TDKLEKMSAEKISELLA 737
L ++ G + E + E + +L+ ++E N +L D+L+K + + I ++ A
Sbjct: 993 LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ-IDQINA 1051
Query: 738 KINHEE---QSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVMEDRRY 793
+N E Q + ++ + +E + ++ +E + SKYK+ I LE IA +E+
Sbjct: 1052 DLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEE--- 1108
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
QL + +E+Q A + E +L + L + D R E+ + + + L++
Sbjct: 1109 -------QLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1161
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
+ L E + Q + + ++ L + D E + + +LR
Sbjct: 1162 LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1209
Score = 59.7 bits (138), Expect = 9e-08
Identities = 120/668 (17%), Positives = 269/668 (40%), Gaps = 43/668 (6%)
Query: 164 KMKIMETTILDLQEKINEKDQI-IEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQ 222
K K +E + +LQ K NE +++ E +K T D+K +K+
Sbjct: 532 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS---DSKS--SKLT 586
Query: 223 ENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXX 282
++F A+E++ +D ++ L ++ K + L++ + R ++ E + LE+
Sbjct: 587 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEEAKHNLEKQI 646
Query: 283 XXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL-TKKIELLEHLNCQIRQT 341
+ S+ E E++ K ++ +++ +K+ + L +
Sbjct: 647 ATLHAQVADMKKKMEDSVG-CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 705
Query: 342 NKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS-KMKSPWSQLSSETLNQDTDK 400
+EL++ L + + ++ + KK + T S K + +E ++T K
Sbjct: 706 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET-K 764
Query: 401 KINK----NEIAKLEMVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
++ E + + ++ LNK + E ++S KD K L Q++
Sbjct: 765 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 824
Query: 456 HQQHMEGPSLIHVGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSAEEQITQ 514
Q E + TED +V Q +K + +++ + + EK K Q+ +
Sbjct: 825 KTQLEELEDELQA---TEDAKLRLEVNLQAMKAQFERDLQGRDEQSE-EKKKQLVRQVRE 880
Query: 515 LNDEI-DAANKNMIKVKSNHKLK--LKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKV 571
+ E+ D + + V + KL+ LK ++ ID+ +K D + I +L + + +
Sbjct: 881 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQLRKLQAQMKDCM 938
Query: 572 AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
EL++ + + + L + +MI+++ L A + Q
Sbjct: 939 RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE----ELAAAERAKRQA-------- 986
Query: 632 ILQQKYDEVEDKLADISQLQS----DQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
QQ+ DE+ D++A+ S + ++ E + LEE+++ + + + ++ L
Sbjct: 987 --QQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1044
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
+Q+ + + N Q ++N +L KL++M S+ A I E
Sbjct: 1045 QIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1104
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
Q + +D + +ER + + K K + ++++ E + ++ + +L +
Sbjct: 1105 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1164
Query: 808 EKQKAYSE 815
+ ++A E
Sbjct: 1165 QLEEAEEE 1172
>BC117132-1|AAI17133.1| 1306|Homo sapiens kinectin 1 (kinesin
receptor) protein.
Length = 1306
Score = 113 bits (273), Expect = 4e-24
Identities = 204/978 (20%), Positives = 433/978 (44%), Gaps = 117/978 (11%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+++++ ++K+ +S ++ Q+ ++K + EQ++A A K+ EN L ++ +
Sbjct: 383 LEKEHNVFQNKI-HVSYQETQQM--QMKFQQVREQMEAEIAHLKQ-----ENGIL-RDAV 433
Query: 693 YGTIKDLENDKEDIMNKL-QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
T LE+ + +NKL Q+Y + +LT+K K+ E++ + + EQ+ Q
Sbjct: 434 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK-----KNAEQAATQ--- 485
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ ++QE + E ++S + K R E A +D + K +++ S L K
Sbjct: 486 -LKVQLQEAERRWEEVQSYIRK------RTAEHEAAQQDLQSKFVAKENEVQS-LHSK-- 535
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
++ + + +L RL LM+ + +K++ ++ + LQ + Q +LE+N+ L+ +
Sbjct: 536 -LTDTLVSKQQLEQRLMQLMESE---QKRV----NKEESLQMQVQDILEQNEALK---AQ 584
Query: 872 MQQHYNALVEKANRTDLAE------SESTKYQTQLRD-LESNLKRITHEHQTLI-VQK-- 921
+QQ ++ + + + + LAE +E K Q D L S R+T + + L +Q
Sbjct: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMN 644
Query: 922 ---KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ-EYKNNIENLNMN 977
K E++ L+ N Q +A +K+ Y K+ + + LE QLQ E N +E +
Sbjct: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD-DKIRLLEEQLQHEISNKMEEFKI- 702
Query: 978 VEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQV 1037
LN N + + VQK QT + + + + ++ +++KDE++ + + + +
Sbjct: 703 ---LNDQN-KALKSEVQKLQTLVSEQPNKDV--VEQMEKCIQEKDEKLKTVEELLETGLI 756
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN---EELQILVREQDDQIK- 1093
V+ E +L T+ ++ +E+Q + + D EEL+ ++ E+D +IK
Sbjct: 757 Q----VATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
Query: 1094 --ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE--- 1148
EL E +L N KT + I+S ++ + N + L+ +E++
Sbjct: 813 VEELLEAELLKVANKEKTVQLSITSKVQELQ---NLLKGKEEQMNTMKAVLEEKEKDLAN 869
Query: 1149 --EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+++Q+ LQE++ L +QE ++ + ++ ++V +E+ N+LK +LE +
Sbjct: 870 TGKWLQD---LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK-RLEAM 925
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV------Q 1260
E ++ LS+ +L + +I +L KQ Q+ + F E L+V +
Sbjct: 926 LKERESDLSSKTQLLQDVQDENKLFKSQIEQL-KQQNYQQASSFPPHEELLKVISEREKE 984
Query: 1261 LSAFESKYEQLLDSVQSSTQEETN----KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+S ++ + L D+V+ ++ + ME + S + LQDK +++ +
Sbjct: 985 ISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEA 1044
Query: 1317 I--NQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQMQEQSILNINE 1372
+ E+L+ V + T ++ E + +E
Sbjct: 1045 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1104
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRND 1432
+ L+ + + V + ++ ++K E ++ + + T
Sbjct: 1105 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164
Query: 1433 EFENVRQQLVEYEKRIEDLTYEKES-ELAILRLKMHENANHYETMQKESEIER--VKLIE 1489
E E +R + K IE+L E+E E+ + + +M + E + ++++ KL
Sbjct: 1165 ELERLRSE----NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRT 1220
Query: 1490 ELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE-----------IVTLND 1538
E N + + L+K L + ++ ++ K T +EN ++ V+LN
Sbjct: 1221 EQNERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ 1279
Query: 1539 EITNLQNMVRASSSKIQK 1556
+T LQ +++A + ++ K
Sbjct: 1280 TVTQLQQLLQAVNQQLTK 1297
Score = 90.2 bits (214), Expect = 5e-17
Identities = 172/879 (19%), Positives = 387/879 (44%), Gaps = 62/879 (7%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
++N++ + +L EL ++ + ++ ++K K+AE+ TQL ++ A + +V+S
Sbjct: 447 ELNKLRQDYARLVNELTEKTGKLQQEE-VQK-KNAEQAATQLKVQLQEAERRWEEVQSYI 504
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ---LHLVDYDS 590
+ ++T ++ + D + V E+ L K+ + K L+ + L++ +
Sbjct: 505 R------KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ 558
Query: 591 GRMIESDVYKKMIEMENLAETRLKA-ISLLESQ------KFDLVQELH-ILQQKYDEV-- 640
R+ + + + ++ LKA I SQ L +ELH ++ +K ++
Sbjct: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
Query: 641 -EDKLA-DISQLQS-DQVCSEIKSVH--LEEQIDALSASKKELALVIENLKLDKEQLYGT 695
ED LA + +L S ++ +I++++ L+ ++ L A E A L+ ++ +Y
Sbjct: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
Query: 696 IKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDA 755
+ +E + +++ N ++E L D+ + + +E + +L ++ + + Q ++
Sbjct: 679 DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSE-VQKLQTLVSEQPNKDVVEQ--MEK 735
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
IQE+D ++ +E L ++ EE + + SL ++ L + Q Q +++
Sbjct: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSFAS 794
Query: 816 YTIQEDELVNRL-AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
+ ++++ + + ++E +LL++ ++ K +Q ++E QNL +
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMN 854
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE---HQTLIVQKKKEIEDLEIE 931
A++E+ + DLA + K+ L++ +LK E H + E+LEI
Sbjct: 855 TMKAVLEEKEK-DLANTG--KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 911
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE----YKNNIENLNM-NVEELNKM-- 984
+ R + +L E+ E ++ TQL +Q+ +K+ IE L N ++ +
Sbjct: 912 LKEKENELKRLEAMLKER-ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 970
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
+ EL+ ++++ S + E ++ + ++K+ ++ N + A S M+
Sbjct: 971 HEELLKVISEREKEISGLWNE--LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQ 1028
Query: 1045 DYESKLA-QFTTKLENMEEEMQRVSKQLLD--SKQHNEELQILVREQDDQIKE-LKETKL 1100
D +K + + ++E +E E + V K+L S N + + + KE + T
Sbjct: 1029 DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1088
Query: 1101 TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ 1160
+ E+ + + + + + L+ E+E + V ++
Sbjct: 1089 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE-NKWKVKVDE 1147
Query: 1161 SAKLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE 1219
S K ++Q +T Q LE L +E + + +E+ L+ +LE+ E ++ V E
Sbjct: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER-EHLEMELEKAEMERSTYVTEVRE 1206
Query: 1220 LRSSISSAVDQRGFEIAELWKQ----HLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L++ ++ + + E E K H AQ+ + +++ V+ + + E S
Sbjct: 1207 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI---VKAAGDTTVIENSDVSP 1263
Query: 1276 QSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKY 1313
++ + E+ V++ Q VT LQ LQ + L +E Y
Sbjct: 1264 ETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHY 1302
Score = 84.2 bits (199), Expect = 3e-15
Identities = 190/1003 (18%), Positives = 423/1003 (42%), Gaps = 80/1003 (7%)
Query: 142 GDVTHLSNTIKEKDNALSVLQVKMKIMETTILDL-QEKINEKDQ----IIEAKNKATTXX 196
G++T L + ++EKD L+ ++ + L QE + EK++ I K++ T
Sbjct: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQR--LLKDIESKDVRISSLE 254
E T+Q K Q+ MEAE KQ +L+D S + LE
Sbjct: 385 KEHNVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT--NQLE 441
Query: 255 EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
A ++ ++++L EL + L ++ ++ E+ + K
Sbjct: 442 SKQS---AELNKLRQDYARLVNELTEKTGK----------LQQEEVQKKNAEQAATQLKV 488
Query: 315 SLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKS 374
L+ A + + + ++L++K + E++ S SK L+S++
Sbjct: 489 QLQEAER-RWEEVQSYIRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQ 545
Query: 375 -GRNTASKMKSPWSQLSSE-TLNQDTDKKINKNEIAKLEM------VIQSLNKDLVDKEY 426
+ M+S +++ E +L + +NE K ++ + + ++ +E
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
Query: 427 --VISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ 484
VI+EKD + + + E + ++ + + + + + +A Q
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKE-EELKDIQNMNFL-LKAEVQKLQALANEQAA 663
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI 544
EL + V VKD +K++ EEQ L EI + + +K ++QK
Sbjct: 664 AAHELEKMQQSVYVKD--DKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQ 718
Query: 545 DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
S+ NK++V E+ + +K +L+ + L+ L+ ++ + I
Sbjct: 719 TLVSE--QPNKDVVEQMEKC--IQEKDEKLKTVEELLETGLI-----QVATKEEELNAIR 769
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
EN + T K + L++++ D V ++++ + +K I ++ + + +E+ V
Sbjct: 770 TENSSLT--KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE-ELLEAELLKVAN 826
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+E+ LS + K L +NL KE+ T+K + +KE + ++Q DL ++
Sbjct: 827 KEKTVQLSITSKVQEL--QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ---DLQEEN 881
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEES 784
E + A + E+ A+ N +E S ++ ++E++ ++ +E+ L + +S + +
Sbjct: 882 ESLKAH-VQEV-AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL 939
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ ++D + + +QL ++ ++ + +EL+ ++ + +L +
Sbjct: 940 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPH----EELLKVISEREKEISGLWNELDSL 995
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
+ + +KKN L E+N +L+ ++ V K ++ + E+ + + + L+
Sbjct: 996 KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK-EVLK 1054
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+++ + E E S + KVL K ++ E T L+ +
Sbjct: 1055 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT-SGSEEVKVLEHKLKEADEMHTLLQLEC 1113
Query: 965 QEYKNNI-------ENLNMNVE-ELNKMNLELIDKHVQKQQTQSP-DYTEQYINEINKLN 1015
++YK+ + + L +VE E NK +++ + H +Q QS +EQ + + N
Sbjct: 1114 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1173
Query: 1016 ALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
++ E L ++ A++ +Y++ V + +++L + TKL + E Q+V+ L
Sbjct: 1174 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1233
Query: 1073 DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
++Q E +Q + + ++ + ++ E + E M +S
Sbjct: 1234 KAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 1276
Score = 82.2 bits (194), Expect = 1e-14
Identities = 163/890 (18%), Positives = 372/890 (41%), Gaps = 86/890 (9%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN- 532
D + K + + K+ N + + + + + K ++ + +D++ N+++ S+
Sbjct: 53 DKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE-DDQVAPVPLNVVETSSSV 111
Query: 533 -HKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
+ K ++ QK + + K SD++K + E + Q E +
Sbjct: 112 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 171
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQ 649
+G SD K +E + R +A+ L + K + K + E+ D
Sbjct: 172 NG----SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPL 227
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-DLENDKEDIMN 708
+ + + + +D K+E+ +++ +++ Q GT K E DKE+
Sbjct: 228 IHATTYIPLMDNADSSPVVD-----KREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 282
Query: 709 KLQNYI----------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K ++++ E + + D L++ S I + L K + E + + Q +Q
Sbjct: 283 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGV-IQDALKKSSKGELTTLIHQ------LQ 335
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYT 817
E+D + ++ + + K R +L + + ++R + R D++G+ +E ++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-----NQILLEENQNLQISLSDM 872
+ E +E ++ ++ EN L+ NQ+ +++ L D
Sbjct: 396 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 455
Query: 873 QQHYNALVEKANRTDLAESESTKYQ---TQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ N L EK + E + + TQL+ +R E Q+ I ++ E E +
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 515
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIENLNMNVEELN 982
+ ++ + + + L+ K + QLE +L Q+ N E+L M V+++
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ N E + +Q+ +Q T + +L+ ++ +KD++I + + + S
Sbjct: 576 EQN-EALKAQIQQFHSQIAAQTSASVLA-EELHKVIAEKDKQIKQTEDSLASERDRLTSK 633
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ + + L+ +++Q ++ + + E++Q V +DD+I+ L+E +L
Sbjct: 634 EEELKD-IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE-QLQH 691
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE-RSVLQEQS 1161
E++ E I++ + + + + + Q ++ +++ +QE+
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTL----------VSEQPNKDVVEQMEKCIQEKD 741
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
KL T + T +IQ+ T +E++N ++ TEN +L V +L+
Sbjct: 742 EKLKTVEELLETGLIQVAT-----------KEEELNAIR-------TENSSLTKEVQDLK 783
Query: 1222 SSISSAVDQRGF-EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
+ + DQ F + E K+ + +++ + E L +L +K + + S+ S Q
Sbjct: 784 AKQN---DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQ 840
Query: 1281 EETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
E N + E Q+ +++ L++KE+ L N + D+ + E L++ +++
Sbjct: 841 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 890
Score = 70.5 bits (165), Expect = 5e-11
Identities = 155/833 (18%), Positives = 342/833 (41%), Gaps = 47/833 (5%)
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
R ++ I D++ + ++K + ++ SE ++ +L + LAV D V
Sbjct: 43 REQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL 102
Query: 840 QLLEIE---HENKELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTK 895
++E E K+ +KK + +LEE + S + + + T +E+ ++K
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + ++ + +TL+V K++ E L + T+ ES KK ++K +
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQ-EALPLHQETKQESGSGKKKASSKKQKTENV 221
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+V + Y ++N + + + ++L+ K Q + Q T++ E +K N
Sbjct: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL-KPDQVEGIQKSG-TKKLKTETDKEN 279
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A +K KD + + + + + +S + Q K ++ + E+ + QL
Sbjct: 280 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQL---- 334
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L V+E K+ + +LT EM K ++ + ++
Sbjct: 335 QEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNT-ELTGHDV 1190
Q + +F Q R ++ + A L E L++ + QLE+ + EL
Sbjct: 394 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ 453
Query: 1191 VNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+N+L K L+Q + N +L+ + A ++R E+ ++ A+ E
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA-ERRWEEVQSYIRKRTAEHE 512
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
A Q + + + + +S + +L D++ S Q E + ME NK + + ++
Sbjct: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM----- 1362
++ E+ + QI+ S+I + A +TE+ +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+E+ + +I N LK ++ E ++ + +KD +I +
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQ 688
Query: 1423 YTITLTQRNDEFENVRQQ---LVEYEKRIEDLTYEKESELAILRLK--MHENANHYETMQ 1477
++ + +EF+ + Q L ++++ L E+ ++ + +++ + E +T++
Sbjct: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 1478 KESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEV---AKTNEMQTALENQEI 1531
+ E +++ EELN TE+ SL K+V +L ++V + E++ + ++
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 1532 EIVTLND----EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
+I ++ + E+ + N + I V + +G++EQ+ NTM L
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQM-NTMKAVL 860
>BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 113 bits (273), Expect = 4e-24
Identities = 188/891 (21%), Positives = 396/891 (44%), Gaps = 90/891 (10%)
Query: 476 NEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
+E A +L +EL D++KD+ V K + A ++ +L ++I N+ +++ +
Sbjct: 529 SEAASGNHRLTEELKDQLKDLKV-----KYEGASAEVGKLRNQI-KQNEMIVEEFKRDEG 582
Query: 536 KL----KQMQKTIDNFSKVSD-SNKEIVRLTEELHHLSQKVA-ELEEEK-GNLQLHLVDY 588
KL K++QK + + +++ + + LS K+A + EK N++ L
Sbjct: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSL--- 639
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL--HILQQKYDEVEDKLAD 646
S + E KK++EME E L I L+ + ++ +L H+ +++++V+ +L
Sbjct: 640 -SNEVNEK--AKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Query: 647 ISQLQSDQVCS-EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
S ++ +K+ L+++I+ + K L NL ++ + Y +K E+ K+
Sbjct: 697 KSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 756
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLY- 763
+ + ++ +D+T K + E LL + ++ S+++T F + + E+++
Sbjct: 757 HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF-VPPEKHEKEIIA 815
Query: 764 ----IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
I ++ +LS+ K + +E I + +L++ Y+ K + T+
Sbjct: 816 LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS--NQYVPVKTHEEVKMTL- 872
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
D L L+D V+K+ +I E +++ KN+IL +NL+ + + ++ Y +L
Sbjct: 873 NDTLAKTNRELLD----VKKKFEDINQEFVKIKDKNEIL---KRNLENTQNQIKAEYISL 925
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQI 936
E + K Q ++ +N ++ E TL I +KKE++ ++ +
Sbjct: 926 AEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY 985
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
+ ++ + E QL Q Q+Y + E + N +E +K+ E+ +QK
Sbjct: 986 APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKD 1043
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D T I + +++ L +K +E LN+++ + Y + V + + KL +
Sbjct: 1044 LR---DKT-VLIEKSHEMERALSRKTDE---LNKQLKDLSQKY-TEVKNVKEKLVE---- 1091
Query: 1057 LENMEEEMQRVSKQLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI- 1113
EN ++ + ++ Q L KQH E+++ L + + I+ LKE + + K + +
Sbjct: 1092 -ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
Query: 1114 -ISSTIE-------PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN 1165
+ +E P+++ + L+ +EEE Q + E+ +KL
Sbjct: 1151 KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES--QNK---MEEVSKLQ 1205
Query: 1166 TELQECYTKIIQLETLN-TELTGHDVVNQE---QINQLKSKLEQLNTENDNLLSTVAELR 1221
+E+Q + +LET +L+ + + QI+ L KL LN + + + V +
Sbjct: 1206 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQRE---------ADFQKTEHELRVQLSAFESKYEQLL 1272
SA D++ + ++ Q+E + Q+ E Q+ A ++K +LL
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
Query: 1273 DSVQSSTQE---ETNKIVTMEQVTSLQNKLQDKEEH-LRNLQEKYADVINQ 1319
+ V+ Q + T T Q++L D +H +++L+++ AD Q
Sbjct: 1326 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
Score = 98.3 bits (234), Expect = 2e-19
Identities = 182/937 (19%), Positives = 395/937 (42%), Gaps = 76/937 (8%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E + L L+VK + + L+ +I + + I+E +
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR--FEISL 269
+ +++ K+ E ME + K+ +L I ++ +N++ E A+ E+
Sbjct: 600 MEREKKGRKVTE----MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
EH K E+ Q K E + K+ +E+K +TELT K +
Sbjct: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKP--EEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
L+ ++ NK L+ + + E K P K + + + + ++
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDM------KKSHDAIIDDLNRK 767
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+ + T+KK+ E+ KL + SL+KD+ E V + L
Sbjct: 768 LLDVTQKYTEKKL---EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELK 824
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSA 508
QL ++ E IH T +E+ N + Q + + ++E+K + + D + K
Sbjct: 825 KQLSELKKKCGEDQEKIHALT-SENTNLKKMMSNQYVPVKTHEEVK-MTLNDTLAK---T 879
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS 568
++ + + + N+ +K+K +++ + ++ T +++ + ++ LS
Sbjct: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT---QNQIKAEYISLAEHEAKMSSLS 936
Query: 569 QKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
Q + ++++ + L +Y G+ ++ ++ + +T + I + K+ +
Sbjct: 937 QSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV----KYAPIV 989
Query: 629 ELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
++K+ E +L D +S+ SE + +++ D L KKE+ + ++L+
Sbjct: 990 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL---KKEIFTLQKDLR- 1045
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
DK L ++E + K ++ DL+ K ++ + + E L + N ++ S+I
Sbjct: 1046 DKTVLIEKSHEME---RALSRKTDELNKQLKDLSQKYTEV--KNVKEKLVEENAKQTSEI 1100
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+ +Q++ + +E +E+ I L+E + M+ R Y E++ L
Sbjct: 1101 ---LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ-RCYEKEQQTVTKLHQLL 1156
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
E QK S LA + EK++ I+ +E ++++Q +EE LQ
Sbjct: 1157 ENQKNSSV----------PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1206
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTLIVQ----K 921
+ + +Q L E DL++ ++TK +TQ+ L L + +++ + + K
Sbjct: 1207 EVQNTKQALKKL-ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 922 KKEI--EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
KKEI +D + + IE I+D+K E+ +K++ +T+L+ ++QE IE + +
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
EL L +++ Q S T N + + L+ ++ +L Q++ +A +
Sbjct: 1323 EL----LNDVERLKQALNGLS-QLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQH 1377
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+++ Y + L + +M+E++Q Q++ +Q
Sbjct: 1378 QEVIAIYRTHL--LSAAQGHMDEDVQEALLQIIQMRQ 1412
Score = 93.1 bits (221), Expect = 8e-18
Identities = 209/1128 (18%), Positives = 482/1128 (42%), Gaps = 98/1128 (8%)
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH---KLKLKQMQKTIDNFSKVSDSNKE 556
D++ LK+A E T E+ ++ + H ++ +K Q+ N + N++
Sbjct: 247 DILTLLKTASEN-TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENED 305
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHL---VDYDSGRMIESDVYKKMIEM-ENLAETR 612
L E L + Q+ L ++ LQL L V E + K ++ E E
Sbjct: 306 ---LKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEES 362
Query: 613 LKAISLLESQKFDLVQELHILQQKY--DEVEDKLADISQL-QSDQVCSEIK-SVHLEEQ- 667
L+ I L++ +F + H+ + + ED L Q+ +D C+ H++ +
Sbjct: 363 LRTIEALKN-RFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 668 -IDALSASKKELALVIEN--LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+ L S EN LK + E + + + D+ + N+L + + E L +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALEC 481
Query: 725 EKM---SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICR 780
E++ S E+I +L + + Q ++ G ++Q L + E++ SE + R+
Sbjct: 482 ERVKEDSDEQIKQLEDALK-DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE 540
Query: 781 -LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE- 838
L++ + ++ + + +L + +++ + E+ E +L+ L + E
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
Query: 839 ------KQLLEIEHENKELQKKNQILL--EENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+++ E+E + KEL K + + E+ +N++ SLS N + EKA + E
Sbjct: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS------NEVNEKAKKLVEME 654
Query: 891 SESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
E K +++R L+ L+ + + Q + ++ ++++ + + ++ I + + N+
Sbjct: 655 REHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQT 714
Query: 950 YEKNIEYVTQLEAQLQEYKNN--IENLNMNV-----EELNKMNLELIDKHVQKQQTQSPD 1002
+K IE V L+E +N IE N V E++ K + +ID +K +
Sbjct: 715 LQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK 774
Query: 1003 YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
YTE+ + E+ KL +++ L + +++ +S + + +L +++
Sbjct: 775 YTEKKL-EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIA-LKSNIVELKKQLSELKK 832
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT--EGMIISSTIEP 1120
+ +++ N L+ ++ Q +K +E K+T + KT E + + E
Sbjct: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 892
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET 1180
++ + + + Q + E+I L E AK+++ L + K+ +
Sbjct: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYIS----LAEHEAKMSS-LSQSMRKV---QD 944
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAEL- 1238
N E+ + QE+I L ++++ E D + + + I S + +R F+ E
Sbjct: 945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE 1004
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQN 1297
K L+++ + +E E++ K ++ + ++Q +++T I + E +L
Sbjct: 1005 LKDQLSEQTQKYSVSEEEVKKNKQE-NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSR 1063
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
K + + L++L +KY +V N ++ ++ +E L + +
Sbjct: 1064 KTDELNKQLKDLSQKYTEVKN----VKEKLVEENAKQTSEILAVQNLLQKQHVPLE-QVE 1118
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
+ K+ +I N+ EE +++ + + + + L L++K++
Sbjct: 1119 ALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA-FE 1177
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
++ +L ++ +E +N +++ + + +++ ++ A+ +L+ E + +
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQN------TKQALKKLETREVVDLSKYKA 1231
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALE---EEV--AKTNEMQTALENQEIE 1532
+S++E T+ SLN+++A LN+ E EEV AK E+ +A + +E+
Sbjct: 1232 TKSDLE------------TQISSLNEKLANLNRKYEEVCEEVLHAKKKEI-SAKDEKELL 1278
Query: 1533 IVTLNDEITNLQNMVRAS---SSKIQKHVSFASDTKQGRDEQLDNTMN 1577
++ EI + + S +++Q+ + ++ + +D ++ +N
Sbjct: 1279 HFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN 1326
Score = 58.4 bits (135), Expect = 2e-07
Identities = 139/705 (19%), Positives = 279/705 (39%), Gaps = 53/705 (7%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEY 956
T ++D E N+K EHQ I + E EDL+ Q E I KV + + N E
Sbjct: 278 THMQD-EVNVKSHQREHQN-IQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 335
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ + L+ + +++L E+ ++ +L I+ + + D+ + N+
Sbjct: 336 M--VADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKED 393
Query: 1017 LLKQKDEEIIALNQKINNAQVSYM---SMVSDYESKLAQFTTKLEN--MEEEMQRVSKQL 1071
+L ++ + +A +Q + ++M SM+ E L T+ EN +++E++ +
Sbjct: 394 MLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 453
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+KQ +LQ E ++ E K L E K + I+ + D +V
Sbjct: 454 ESAKQDRLKLQ---NELAHKVAECKA--LALECERVKEDS---DEQIKQLEDALKDVQKR 505
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
Q + F+ + L ++A N L E QL+ L + G
Sbjct: 506 MYESEGKVK----QMQTHFLALKEHLTSEAASGNHRLTEELKD--QLKDLKVKYEGASAE 559
Query: 1192 NQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
+ NQ+K +E+ + L+ L+ +S +R K+ E
Sbjct: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE-------KKGRKVTEM 612
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ-NKLQDKEEHLR 1307
+ Q E ++ LS K+E + S+ + E+ K+V ME+ ++++ + L
Sbjct: 613 EGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE 672
Query: 1308 NLQEKYADVI--NQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR---TENQSYKQM 1362
N++ K A + + E ++S +E + ++ +N+ K+
Sbjct: 673 NVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 732
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+ + LK S ++D K+L++T + K E+ +K
Sbjct: 733 AHNLTIEMKNHYVPLKVSEDMKKSHDAI----IDDLNRKLLDVTQKYTEKKLEM-EKLLL 787
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDL---TYEKESELAILRLKMHENANHYETMQKE 1479
+L++ E V ++EK I L E + +L+ L+ K E+ + E
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 1480 -SEIERVKLIEELNVKITESV--SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
+ ++++ + + VK E V +LN +A+ N+ L + K ++ + + L
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL 907
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
+ N QN ++A + +H + S Q + D+ N E+L
Sbjct: 908 KRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS--NAEIL 950
>BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 113 bits (273), Expect = 4e-24
Identities = 188/891 (21%), Positives = 396/891 (44%), Gaps = 90/891 (10%)
Query: 476 NEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
+E A +L +EL D++KD+ V K + A ++ +L ++I N+ +++ +
Sbjct: 529 SEAASGNHRLTEELKDQLKDLKV-----KYEGASAEVGKLRNQI-KQNEMIVEEFKRDEG 582
Query: 536 KL----KQMQKTIDNFSKVSD-SNKEIVRLTEELHHLSQKVA-ELEEEK-GNLQLHLVDY 588
KL K++QK + + +++ + + LS K+A + EK N++ L
Sbjct: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSL--- 639
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL--HILQQKYDEVEDKLAD 646
S + E KK++EME E L I L+ + ++ +L H+ +++++V+ +L
Sbjct: 640 -SNEVNEK--AKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Query: 647 ISQLQSDQVCS-EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
S ++ +K+ L+++I+ + K L NL ++ + Y +K E+ K+
Sbjct: 697 KSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 756
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLY- 763
+ + ++ +D+T K + E LL + ++ S+++T F + + E+++
Sbjct: 757 HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF-VPPEKHEKEIIA 815
Query: 764 ----IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
I ++ +LS+ K + +E I + +L++ Y+ K + T+
Sbjct: 816 LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS--NQYVPVKTHEEVKMTL- 872
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
D L L+D V+K+ +I E +++ KN+IL +NL+ + + ++ Y +L
Sbjct: 873 NDTLAKTNRELLD----VKKKFEDINQEFVKIKDKNEIL---KRNLENTQNQIKAEYISL 925
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQI 936
E + K Q ++ +N ++ E TL I +KKE++ ++ +
Sbjct: 926 AEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY 985
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
+ ++ + E QL Q Q+Y + E + N +E +K+ E+ +QK
Sbjct: 986 APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKD 1043
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D T I + +++ L +K +E LN+++ + Y + V + + KL +
Sbjct: 1044 LR---DKT-VLIEKSHEMERALSRKTDE---LNKQLKDLSQKY-TEVKNVKEKLVE---- 1091
Query: 1057 LENMEEEMQRVSKQLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI- 1113
EN ++ + ++ Q L KQH E+++ L + + I+ LKE + + K + +
Sbjct: 1092 -ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
Query: 1114 -ISSTIE-------PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN 1165
+ +E P+++ + L+ +EEE Q + E+ +KL
Sbjct: 1151 KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES--QNK---MEEVSKLQ 1205
Query: 1166 TELQECYTKIIQLETLN-TELTGHDVVNQE---QINQLKSKLEQLNTENDNLLSTVAELR 1221
+E+Q + +LET +L+ + + QI+ L KL LN + + + V +
Sbjct: 1206 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQRE---------ADFQKTEHELRVQLSAFESKYEQLL 1272
SA D++ + ++ Q+E + Q+ E Q+ A ++K +LL
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
Query: 1273 DSVQSSTQE---ETNKIVTMEQVTSLQNKLQDKEEH-LRNLQEKYADVINQ 1319
+ V+ Q + T T Q++L D +H +++L+++ AD Q
Sbjct: 1326 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
Score = 98.3 bits (234), Expect = 2e-19
Identities = 182/937 (19%), Positives = 395/937 (42%), Gaps = 76/937 (8%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E + L L+VK + + L+ +I + + I+E +
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR--FEISL 269
+ +++ K+ E ME + K+ +L I ++ +N++ E A+ E+
Sbjct: 600 MEREKKGRKVTE----MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
EH K E+ Q K E + K+ +E+K +TELT K +
Sbjct: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKP--EEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
L+ ++ NK L+ + + E K P K + + + + ++
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDM------KKSHDAIIDDLNRK 767
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+ + T+KK+ E+ KL + SL+KD+ E V + L
Sbjct: 768 LLDVTQKYTEKKL---EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELK 824
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSA 508
QL ++ E IH T +E+ N + Q + + ++E+K + + D + K
Sbjct: 825 KQLSELKKKCGEDQEKIHALT-SENTNLKKMMSNQYVPVKTHEEVK-MTLNDTLAK---T 879
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS 568
++ + + + N+ +K+K +++ + ++ T +++ + ++ LS
Sbjct: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT---QNQIKAEYISLAEHEAKMSSLS 936
Query: 569 QKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
Q + ++++ + L +Y G+ ++ ++ + +T + I + K+ +
Sbjct: 937 QSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV----KYAPIV 989
Query: 629 ELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
++K+ E +L D +S+ SE + +++ D L KKE+ + ++L+
Sbjct: 990 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL---KKEIFTLQKDLR- 1045
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
DK L ++E + K ++ DL+ K ++ + + E L + N ++ S+I
Sbjct: 1046 DKTVLIEKSHEME---RALSRKTDELNKQLKDLSQKYTEV--KNVKEKLVEENAKQTSEI 1100
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+ +Q++ + +E +E+ I L+E + M+ R Y E++ L
Sbjct: 1101 ---LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ-RCYEKEQQTVTKLHQLL 1156
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
E QK S LA + EK++ I+ +E ++++Q +EE LQ
Sbjct: 1157 ENQKNSSV----------PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1206
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTLIVQ----K 921
+ + +Q L E DL++ ++TK +TQ+ L L + +++ + + K
Sbjct: 1207 EVQNTKQALKKL-ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 922 KKEI--EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
KKEI +D + + IE I+D+K E+ +K++ +T+L+ ++QE IE + +
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
EL L +++ Q S T N + + L+ ++ +L Q++ +A +
Sbjct: 1323 EL----LNDVERLKQALNGLS-QLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQH 1377
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+++ Y + L + +M+E++Q Q++ +Q
Sbjct: 1378 QEVIAIYRTHL--LSAAQGHMDEDVQEALLQIIQMRQ 1412
Score = 93.1 bits (221), Expect = 8e-18
Identities = 209/1128 (18%), Positives = 482/1128 (42%), Gaps = 98/1128 (8%)
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH---KLKLKQMQKTIDNFSKVSDSNKE 556
D++ LK+A E T E+ ++ + H ++ +K Q+ N + N++
Sbjct: 247 DILTLLKTASEN-TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENED 305
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHL---VDYDSGRMIESDVYKKMIEM-ENLAETR 612
L E L + Q+ L ++ LQL L V E + K ++ E E
Sbjct: 306 ---LKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEES 362
Query: 613 LKAISLLESQKFDLVQELHILQQKY--DEVEDKLADISQL-QSDQVCSEIK-SVHLEEQ- 667
L+ I L++ +F + H+ + + ED L Q+ +D C+ H++ +
Sbjct: 363 LRTIEALKN-RFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 668 -IDALSASKKELALVIEN--LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+ L S EN LK + E + + + D+ + N+L + + E L +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALEC 481
Query: 725 EKM---SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICR 780
E++ S E+I +L + + Q ++ G ++Q L + E++ SE + R+
Sbjct: 482 ERVKEDSDEQIKQLEDALK-DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE 540
Query: 781 -LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE- 838
L++ + ++ + + +L + +++ + E+ E +L+ L + E
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
Query: 839 ------KQLLEIEHENKELQKKNQILL--EENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+++ E+E + KEL K + + E+ +N++ SLS N + EKA + E
Sbjct: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS------NEVNEKAKKLVEME 654
Query: 891 SESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
E K +++R L+ L+ + + Q + ++ ++++ + + ++ I + + N+
Sbjct: 655 REHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQT 714
Query: 950 YEKNIEYVTQLEAQLQEYKNN--IENLNMNV-----EELNKMNLELIDKHVQKQQTQSPD 1002
+K IE V L+E +N IE N V E++ K + +ID +K +
Sbjct: 715 LQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK 774
Query: 1003 YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
YTE+ + E+ KL +++ L + +++ +S + + +L +++
Sbjct: 775 YTEKKL-EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIA-LKSNIVELKKQLSELKK 832
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT--EGMIISSTIEP 1120
+ +++ N L+ ++ Q +K +E K+T + KT E + + E
Sbjct: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 892
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET 1180
++ + + + Q + E+I L E AK+++ L + K+ +
Sbjct: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYIS----LAEHEAKMSS-LSQSMRKV---QD 944
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAEL- 1238
N E+ + QE+I L ++++ E D + + + I S + +R F+ E
Sbjct: 945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE 1004
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQN 1297
K L+++ + +E E++ K ++ + ++Q +++T I + E +L
Sbjct: 1005 LKDQLSEQTQKYSVSEEEVKKNKQE-NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSR 1063
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
K + + L++L +KY +V N ++ ++ +E L + +
Sbjct: 1064 KTDELNKQLKDLSQKYTEVKN----VKEKLVEENAKQTSEILAVQNLLQKQHVPLE-QVE 1118
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
+ K+ +I N+ EE +++ + + + + L L++K++
Sbjct: 1119 ALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA-FE 1177
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
++ +L ++ +E +N +++ + + +++ ++ A+ +L+ E + +
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQN------TKQALKKLETREVVDLSKYKA 1231
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALE---EEV--AKTNEMQTALENQEIE 1532
+S++E T+ SLN+++A LN+ E EEV AK E+ +A + +E+
Sbjct: 1232 TKSDLE------------TQISSLNEKLANLNRKYEEVCEEVLHAKKKEI-SAKDEKELL 1278
Query: 1533 IVTLNDEITNLQNMVRAS---SSKIQKHVSFASDTKQGRDEQLDNTMN 1577
++ EI + + S +++Q+ + ++ + +D ++ +N
Sbjct: 1279 HFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN 1326
Score = 58.4 bits (135), Expect = 2e-07
Identities = 139/705 (19%), Positives = 279/705 (39%), Gaps = 53/705 (7%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEY 956
T ++D E N+K EHQ I + E EDL+ Q E I KV + + N E
Sbjct: 278 THMQD-EVNVKSHQREHQN-IQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 335
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ + L+ + +++L E+ ++ +L I+ + + D+ + N+
Sbjct: 336 M--VADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKED 393
Query: 1017 LLKQKDEEIIALNQKINNAQVSYM---SMVSDYESKLAQFTTKLEN--MEEEMQRVSKQL 1071
+L ++ + +A +Q + ++M SM+ E L T+ EN +++E++ +
Sbjct: 394 MLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 453
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+KQ +LQ E ++ E K L E K + I+ + D +V
Sbjct: 454 ESAKQDRLKLQ---NELAHKVAECKA--LALECERVKEDS---DEQIKQLEDALKDVQKR 505
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
Q + F+ + L ++A N L E QL+ L + G
Sbjct: 506 MYESEGKVK----QMQTHFLALKEHLTSEAASGNHRLTEELKD--QLKDLKVKYEGASAE 559
Query: 1192 NQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
+ NQ+K +E+ + L+ L+ +S +R K+ E
Sbjct: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE-------KKGRKVTEM 612
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ-NKLQDKEEHLR 1307
+ Q E ++ LS K+E + S+ + E+ K+V ME+ ++++ + L
Sbjct: 613 EGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE 672
Query: 1308 NLQEKYADVI--NQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR---TENQSYKQM 1362
N++ K A + + E ++S +E + ++ +N+ K+
Sbjct: 673 NVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 732
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+ + LK S ++D K+L++T + K E+ +K
Sbjct: 733 AHNLTIEMKNHYVPLKVSEDMKKSHDAI----IDDLNRKLLDVTQKYTEKKLEM-EKLLL 787
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDL---TYEKESELAILRLKMHENANHYETMQKE 1479
+L++ E V ++EK I L E + +L+ L+ K E+ + E
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 1480 -SEIERVKLIEELNVKITESV--SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
+ ++++ + + VK E V +LN +A+ N+ L + K ++ + + L
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL 907
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
+ N QN ++A + +H + S Q + D+ N E+L
Sbjct: 908 KRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS--NAEIL 950
>BC112337-1|AAI12338.1| 1306|Homo sapiens kinectin 1 (kinesin
receptor) protein.
Length = 1306
Score = 113 bits (273), Expect = 4e-24
Identities = 204/978 (20%), Positives = 433/978 (44%), Gaps = 117/978 (11%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+++++ ++K+ +S ++ Q+ ++K + EQ++A A K+ EN L ++ +
Sbjct: 383 LEKEHNVFQNKI-HVSYQETQQM--QMKFQQVREQMEAEIAHLKQ-----ENGIL-RDAV 433
Query: 693 YGTIKDLENDKEDIMNKL-QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
T LE+ + +NKL Q+Y + +LT+K K+ E++ + + EQ+ Q
Sbjct: 434 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK-----KNAEQAATQ--- 485
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ ++QE + E ++S + K R E A +D + K +++ S L K
Sbjct: 486 -LKVQLQEAERRWEEVQSYIRK------RTAEHEAAQQDLQSKFVAKENEVQS-LHSK-- 535
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
++ + + +L RL LM+ + +K++ ++ + LQ + Q +LE+N+ L+ +
Sbjct: 536 -LTDTLVSKQQLEQRLMQLMESE---QKRV----NKEESLQMQVQDILEQNEALK---AQ 584
Query: 872 MQQHYNALVEKANRTDLAE------SESTKYQTQLRD-LESNLKRITHEHQTLI-VQK-- 921
+QQ ++ + + + + LAE +E K Q D L S R+T + + L +Q
Sbjct: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMN 644
Query: 922 ---KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ-EYKNNIENLNMN 977
K E++ L+ N Q +A +K+ Y K+ + + LE QLQ E N +E +
Sbjct: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD-DKIRLLEEQLQHEISNKMEEFKI- 702
Query: 978 VEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQV 1037
LN N + + VQK QT + + + + ++ +++KDE++ + + + +
Sbjct: 703 ---LNDQN-KALKSEVQKLQTLVSEQPNKDV--VEQMEKCIQEKDEKLKTVEELLETGLI 756
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN---EELQILVREQDDQIK- 1093
V+ E +L T+ ++ +E+Q + + D EEL+ ++ E+D +IK
Sbjct: 757 Q----VATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
Query: 1094 --ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE--- 1148
EL E +L N KT + I+S ++ + N + L+ +E++
Sbjct: 813 VEELLEAELLKVANKEKTVQLSITSKVQELQ---NLLKGKEEQMNTMKAVLEEKEKDLAN 869
Query: 1149 --EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+++Q+ LQE++ L +QE ++ + ++ ++V +E+ N+LK +LE +
Sbjct: 870 TGKWLQD---LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK-RLEAM 925
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV------Q 1260
E ++ LS+ +L + +I +L KQ Q+ + F E L+V +
Sbjct: 926 LKERESDLSSKTQLLQDVQDENKLFKSQIEQL-KQQNYQQASSFPPHEELLKVISEREKE 984
Query: 1261 LSAFESKYEQLLDSVQSSTQEETN----KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+S ++ + L D+V+ ++ + ME + S + LQDK +++ +
Sbjct: 985 ISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEA 1044
Query: 1317 I--NQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQMQEQSILNINE 1372
+ E+L+ V + T ++ E + +E
Sbjct: 1045 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1104
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRND 1432
+ L+ + + V + ++ ++K E ++ + + T
Sbjct: 1105 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164
Query: 1433 EFENVRQQLVEYEKRIEDLTYEKES-ELAILRLKMHENANHYETMQKESEIER--VKLIE 1489
E E +R + K IE+L E+E E+ + + +M + E + ++++ KL
Sbjct: 1165 ELERLRSE----NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRT 1220
Query: 1490 ELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE-----------IVTLND 1538
E N + + L+K L + ++ ++ K T +EN ++ V+LN
Sbjct: 1221 EQNERQKVAGDLHKAQQSL-ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ 1279
Query: 1539 EITNLQNMVRASSSKIQK 1556
+T LQ +++A + ++ K
Sbjct: 1280 TVTQLQQLLQAVNQQLTK 1297
Score = 90.2 bits (214), Expect = 5e-17
Identities = 172/879 (19%), Positives = 387/879 (44%), Gaps = 62/879 (7%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
++N++ + +L EL ++ + ++ ++K K+AE+ TQL ++ A + +V+S
Sbjct: 447 ELNKLRQDYARLVNELTEKTGKLQQEE-VQK-KNAEQAATQLKVQLQEAERRWEEVQSYI 504
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ---LHLVDYDS 590
+ ++T ++ + D + V E+ L K+ + K L+ + L++ +
Sbjct: 505 R------KRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ 558
Query: 591 GRMIESDVYKKMIEMENLAETRLKA-ISLLESQ------KFDLVQELH-ILQQKYDEV-- 640
R+ + + + ++ LKA I SQ L +ELH ++ +K ++
Sbjct: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
Query: 641 -EDKLA-DISQLQS-DQVCSEIKSVH--LEEQIDALSASKKELALVIENLKLDKEQLYGT 695
ED LA + +L S ++ +I++++ L+ ++ L A E A L+ ++ +Y
Sbjct: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
Query: 696 IKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDA 755
+ +E + +++ N ++E L D+ + + +E + +L ++ + + Q ++
Sbjct: 679 DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSE-VQKLQTLVSEQPNKDVVEQ--MEK 735
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
IQE+D ++ +E L ++ EE + + SL ++ L + Q Q +++
Sbjct: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSFAS 794
Query: 816 YTIQEDELVNRL-AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ 874
+ ++++ + + ++E +LL++ ++ K +Q ++E QNL +
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMN 854
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE---HQTLIVQKKKEIEDLEIE 931
A++E+ + DLA + K+ L++ +LK E H + E+LEI
Sbjct: 855 TMKAVLEEKEK-DLANTG--KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 911
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE----YKNNIENLNM-NVEELNKM-- 984
+ R + +L E+ E ++ TQL +Q+ +K+ IE L N ++ +
Sbjct: 912 LKEKENELKRLEAMLKER-ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 970
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
+ EL+ ++++ S + E ++ + ++K+ ++ N + A S M+
Sbjct: 971 HEELLKVISEREKEISGLWNE--LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQ 1028
Query: 1045 DYESKLA-QFTTKLENMEEEMQRVSKQLLD--SKQHNEELQILVREQDDQIKE-LKETKL 1100
D +K + + ++E +E E + V K+L S N + + + KE + T
Sbjct: 1029 DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1088
Query: 1101 TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ 1160
+ E+ + + + + + L+ E+E + V ++
Sbjct: 1089 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE-NKWKVKVDE 1147
Query: 1161 SAKLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE 1219
S K ++Q +T Q LE L +E + + +E+ L+ +LE+ E ++ V E
Sbjct: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER-EHLEMELEKAEMERSTYVTEVRE 1206
Query: 1220 LRSSISSAVDQRGFEIAELWKQ----HLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L++ ++ + + E E K H AQ+ + +++ V+ + + E S
Sbjct: 1207 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI---VKAAGDTTVIENSDVSP 1263
Query: 1276 QSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKY 1313
++ + E+ V++ Q VT LQ LQ + L +E Y
Sbjct: 1264 ETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHY 1302
Score = 84.2 bits (199), Expect = 3e-15
Identities = 190/1003 (18%), Positives = 423/1003 (42%), Gaps = 80/1003 (7%)
Query: 142 GDVTHLSNTIKEKDNALSVLQVKMKIMETTILDL-QEKINEKDQ----IIEAKNKATTXX 196
G++T L + ++EKD L+ ++ + L QE + EK++ I K++ T
Sbjct: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQR--LLKDIESKDVRISSLE 254
E T+Q K Q+ MEAE KQ +L+D S + LE
Sbjct: 385 KEHNVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT--NQLE 441
Query: 255 EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
A ++ ++++L EL + L ++ ++ E+ + K
Sbjct: 442 SKQS---AELNKLRQDYARLVNELTEKTGK----------LQQEEVQKKNAEQAATQLKV 488
Query: 315 SLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKS 374
L+ A + + + ++L++K + E++ S SK L+S++
Sbjct: 489 QLQEAER-RWEEVQSYIRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQ 545
Query: 375 -GRNTASKMKSPWSQLSSE-TLNQDTDKKINKNEIAKLEM------VIQSLNKDLVDKEY 426
+ M+S +++ E +L + +NE K ++ + + ++ +E
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
Query: 427 --VISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ 484
VI+EKD + + + E + ++ + + + + + +A Q
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKE-EELKDIQNMNFL-LKAEVQKLQALANEQAA 663
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI 544
EL + V VKD +K++ EEQ L EI + + +K ++QK
Sbjct: 664 AAHELEKMQQSVYVKD--DKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQ 718
Query: 545 DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
S+ NK++V E+ + +K +L+ + L+ L+ ++ + I
Sbjct: 719 TLVSE--QPNKDVVEQMEKC--IQEKDEKLKTVEELLETGLI-----QVATKEEELNAIR 769
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
EN + T K + L++++ D V ++++ + +K I ++ + + +E+ V
Sbjct: 770 TENSSLT--KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE-ELLEAELLKVAN 826
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+E+ LS + K L +NL KE+ T+K + +KE + ++Q DL ++
Sbjct: 827 KEKTVQLSITSKVQEL--QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ---DLQEEN 881
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEES 784
E + A + E+ A+ N +E S ++ ++E++ ++ +E+ L + +S + +
Sbjct: 882 ESLKAH-VQEV-AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL 939
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ ++D + + +QL ++ ++ + +EL+ ++ + +L +
Sbjct: 940 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPH----EELLKVISEREKEISGLWNELDSL 995
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
+ + +KKN L E+N +L+ ++ V K ++ + E+ + + + L+
Sbjct: 996 KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK-EVLK 1054
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+++ + E E S + KVL K ++ E T L+ +
Sbjct: 1055 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT-SGSEEVKVLEHKLKEADEMHTLLQLEC 1113
Query: 965 QEYKNNI-------ENLNMNVE-ELNKMNLELIDKHVQKQQTQSP-DYTEQYINEINKLN 1015
++YK+ + + L +VE E NK +++ + H +Q QS +EQ + + N
Sbjct: 1114 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1173
Query: 1016 ALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
++ E L ++ A++ +Y++ V + +++L + TKL + E Q+V+ L
Sbjct: 1174 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1233
Query: 1073 DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
++Q E +Q + + ++ + ++ E + E M +S
Sbjct: 1234 KAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 1276
Score = 82.2 bits (194), Expect = 1e-14
Identities = 163/890 (18%), Positives = 372/890 (41%), Gaps = 86/890 (9%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN- 532
D + K + + K+ N + + + + + K ++ + +D++ N+++ S+
Sbjct: 53 DKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE-DDQVAPVPLNVVETSSSV 111
Query: 533 -HKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
+ K ++ QK + + K SD++K + E + Q E +
Sbjct: 112 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 171
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQ 649
+G SD K +E + R +A+ L + K + K + E+ D
Sbjct: 172 NG----SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPL 227
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-DLENDKEDIMN 708
+ + + + +D K+E+ +++ +++ Q GT K E DKE+
Sbjct: 228 IHATTYIPLMDNADSSPVVD-----KREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 282
Query: 709 KLQNYI----------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K ++++ E + + D L++ S I + L K + E + + Q +Q
Sbjct: 283 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGV-IQDALKKSSKGELTTLIHQ------LQ 335
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYT 817
E+D + ++ + + K R +L + + ++R + R D++G+ +E ++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-----NQILLEENQNLQISLSDM 872
+ E +E ++ ++ EN L+ NQ+ +++ L D
Sbjct: 396 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 455
Query: 873 QQHYNALVEKANRTDLAESESTKYQ---TQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ N L EK + E + + TQL+ +R E Q+ I ++ E E +
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 515
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIENLNMNVEELN 982
+ ++ + + + L+ K + QLE +L Q+ N E+L M V+++
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ N E + +Q+ +Q T + +L+ ++ +KD++I + + + S
Sbjct: 576 EQN-EALKAQIQQFHSQIAAQTSASVLA-EELHKVIAEKDKQIKQTEDSLASERDRLTSK 633
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ + + L+ +++Q ++ + + E++Q V +DD+I+ L+E +L
Sbjct: 634 EEELKD-IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE-QLQH 691
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE-RSVLQEQS 1161
E++ E I++ + + + + + Q ++ +++ +QE+
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTL----------VSEQPNKDVVEQMEKCIQEKD 741
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
KL T + T +IQ+ T +E++N ++ TEN +L V +L+
Sbjct: 742 EKLKTVEELLETGLIQVAT-----------KEEELNAIR-------TENSSLTKEVQDLK 783
Query: 1222 SSISSAVDQRGF-EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
+ + DQ F + E K+ + +++ + E L +L +K + + S+ S Q
Sbjct: 784 AKQN---DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQ 840
Query: 1281 EETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
E N + E Q+ +++ L++KE+ L N + D+ + E L++ +++
Sbjct: 841 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 890
Score = 70.5 bits (165), Expect = 5e-11
Identities = 155/833 (18%), Positives = 342/833 (41%), Gaps = 47/833 (5%)
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
R ++ I D++ + ++K + ++ SE ++ +L + LAV D V
Sbjct: 43 REQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL 102
Query: 840 QLLEIE---HENKELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTK 895
++E E K+ +KK + +LEE + S + + + T +E+ ++K
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + ++ + +TL+V K++ E L + T+ ES KK ++K +
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQ-EALPLHQETKQESGSGKKKASSKKQKTENV 221
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+V + Y ++N + + + ++L+ K Q + Q T++ E +K N
Sbjct: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL-KPDQVEGIQKSG-TKKLKTETDKEN 279
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A +K KD + + + + + +S + Q K ++ + E+ + QL
Sbjct: 280 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQL---- 334
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L V+E K+ + +LT EM K ++ + ++
Sbjct: 335 QEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNT-ELTGHDV 1190
Q + +F Q R ++ + A L E L++ + QLE+ + EL
Sbjct: 394 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ 453
Query: 1191 VNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+N+L K L+Q + N +L+ + A ++R E+ ++ A+ E
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA-ERRWEEVQSYIRKRTAEHE 512
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
A Q + + + + +S + +L D++ S Q E + ME NK + + ++
Sbjct: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM----- 1362
++ E+ + QI+ S+I + A +TE+ +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+E+ + +I N LK ++ E ++ + +KD +I +
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQ 688
Query: 1423 YTITLTQRNDEFENVRQQ---LVEYEKRIEDLTYEKESELAILRLK--MHENANHYETMQ 1477
++ + +EF+ + Q L ++++ L E+ ++ + +++ + E +T++
Sbjct: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 1478 KESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEV---AKTNEMQTALENQEI 1531
+ E +++ EELN TE+ SL K+V +L ++V + E++ + ++
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 1532 EIVTLND----EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
+I ++ + E+ + N + I V + +G++EQ+ NTM L
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQM-NTMKAVL 860
>AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein.
Length = 1416
Score = 113 bits (273), Expect = 4e-24
Identities = 188/891 (21%), Positives = 396/891 (44%), Gaps = 90/891 (10%)
Query: 476 NEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
+E A +L +EL D++KD+ V K + A ++ +L ++I N+ +++ +
Sbjct: 529 SEAASGNHRLTEELKDQLKDLKV-----KYEGASAEVGKLRNQI-KQNEMIVEEFKRDEG 582
Query: 536 KL----KQMQKTIDNFSKVSD-SNKEIVRLTEELHHLSQKVA-ELEEEK-GNLQLHLVDY 588
KL K++QK + + +++ + + LS K+A + EK N++ L
Sbjct: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSL--- 639
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL--HILQQKYDEVEDKLAD 646
S + E KK++EME E L I L+ + ++ +L H+ +++++V+ +L
Sbjct: 640 -SNEVNEK--AKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Query: 647 ISQLQSDQVCS-EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
S ++ +K+ L+++I+ + K L NL ++ + Y +K E+ K+
Sbjct: 697 KSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 756
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLY- 763
+ + ++ +D+T K + E LL + ++ S+++T F + + E+++
Sbjct: 757 HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF-VPPEKHEKEIIA 815
Query: 764 ----IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
I ++ +LS+ K + +E I + +L++ Y+ K + T+
Sbjct: 816 LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS--NQYVPVKTHEEVKMTL- 872
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
D L L+D V+K+ +I E +++ KN+IL +NL+ + + ++ Y +L
Sbjct: 873 NDTLAKTNRELLD----VKKKFEDINQEFVKIKDKNEIL---KRNLENTQNQIKAEYISL 925
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQI 936
E + K Q ++ +N ++ E TL I +KKE++ ++ +
Sbjct: 926 AEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY 985
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
+ ++ + E QL Q Q+Y + E + N +E +K+ E+ +QK
Sbjct: 986 APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKD 1043
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D T I + +++ L +K +E LN+++ + Y + V + + KL +
Sbjct: 1044 LR---DKT-VLIEKSHEMERALSRKTDE---LNKQLKDLSQKY-TEVKNVKEKLVE---- 1091
Query: 1057 LENMEEEMQRVSKQLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI- 1113
EN ++ + ++ Q L KQH E+++ L + + I+ LKE + + K + +
Sbjct: 1092 -ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
Query: 1114 -ISSTIE-------PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN 1165
+ +E P+++ + L+ +EEE Q + E+ +KL
Sbjct: 1151 KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES--QNK---MEEVSKLQ 1205
Query: 1166 TELQECYTKIIQLETLN-TELTGHDVVNQE---QINQLKSKLEQLNTENDNLLSTVAELR 1221
+E+Q + +LET +L+ + + QI+ L KL LN + + + V +
Sbjct: 1206 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQRE---------ADFQKTEHELRVQLSAFESKYEQLL 1272
SA D++ + ++ Q+E + Q+ E Q+ A ++K +LL
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
Query: 1273 DSVQSSTQE---ETNKIVTMEQVTSLQNKLQDKEEH-LRNLQEKYADVINQ 1319
+ V+ Q + T T Q++L D +H +++L+++ AD Q
Sbjct: 1326 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
Score = 98.3 bits (234), Expect = 2e-19
Identities = 182/937 (19%), Positives = 395/937 (42%), Gaps = 76/937 (8%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E + L L+VK + + L+ +I + + I+E +
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR--FEISL 269
+ +++ K+ E ME + K+ +L I ++ +N++ E A+ E+
Sbjct: 600 MEREKKGRKVTE----MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
EH K E+ Q K E + K+ +E+K +TELT K +
Sbjct: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKP--EEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
L+ ++ NK L+ + + E K P K + + + + ++
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDM------KKSHDAIIDDLNRK 767
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+ + T+KK+ E+ KL + SL+KD+ E V + L
Sbjct: 768 LLDVTQKYTEKKL---EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELK 824
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSA 508
QL ++ E IH T +E+ N + Q + + ++E+K + + D + K
Sbjct: 825 KQLSELKKKCGEDQEKIHALT-SENTNLKKMMSNQYVPVKTHEEVK-MTLNDTLAK---T 879
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS 568
++ + + + N+ +K+K +++ + ++ T +++ + ++ LS
Sbjct: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT---QNQIKAEYISLAEHEAKMSSLS 936
Query: 569 QKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
Q + ++++ + L +Y G+ ++ ++ + +T + I + K+ +
Sbjct: 937 QSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV----KYAPIV 989
Query: 629 ELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
++K+ E +L D +S+ SE + +++ D L KKE+ + ++L+
Sbjct: 990 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL---KKEIFTLQKDLR- 1045
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
DK L ++E + K ++ DL+ K ++ + + E L + N ++ S+I
Sbjct: 1046 DKTVLIEKSHEME---RALSRKTDELNKQLKDLSQKYTEV--KNVKEKLVEENAKQTSEI 1100
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+ +Q++ + +E +E+ I L+E + M+ R Y E++ L
Sbjct: 1101 ---LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ-RCYEKEQQTVTKLHQLL 1156
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
E QK S LA + EK++ I+ +E ++++Q +EE LQ
Sbjct: 1157 ENQKNSSV----------PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1206
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTLIVQ----K 921
+ + +Q L E DL++ ++TK +TQ+ L L + +++ + + K
Sbjct: 1207 EVQNTKQALKKL-ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 922 KKEI--EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
KKEI +D + + IE I+D+K E+ +K++ +T+L+ ++QE IE + +
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
EL L +++ Q S T N + + L+ ++ +L Q++ +A +
Sbjct: 1323 EL----LNDVERLKQALNGLS-QLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQH 1377
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+++ Y + L + +M+E++Q Q++ +Q
Sbjct: 1378 QEVIAIYRTHL--LSAAQGHMDEDVQEALLQIIQMRQ 1412
Score = 93.1 bits (221), Expect = 8e-18
Identities = 209/1128 (18%), Positives = 482/1128 (42%), Gaps = 98/1128 (8%)
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH---KLKLKQMQKTIDNFSKVSDSNKE 556
D++ LK+A E T E+ ++ + H ++ +K Q+ N + N++
Sbjct: 247 DILTLLKTASEN-TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENED 305
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHL---VDYDSGRMIESDVYKKMIEM-ENLAETR 612
L E L + Q+ L ++ LQL L V E + K ++ E E
Sbjct: 306 ---LKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEES 362
Query: 613 LKAISLLESQKFDLVQELHILQQKY--DEVEDKLADISQL-QSDQVCSEIK-SVHLEEQ- 667
L+ I L++ +F + H+ + + ED L Q+ +D C+ H++ +
Sbjct: 363 LRTIEALKN-RFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 668 -IDALSASKKELALVIEN--LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+ L S EN LK + E + + + D+ + N+L + + E L +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALEC 481
Query: 725 EKM---SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICR 780
E++ S E+I +L + + Q ++ G ++Q L + E++ SE + R+
Sbjct: 482 ERVKEDSDEQIKQLEDALK-DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE 540
Query: 781 -LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE- 838
L++ + ++ + + +L + +++ + E+ E +L+ L + E
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
Query: 839 ------KQLLEIEHENKELQKKNQILL--EENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+++ E+E + KEL K + + E+ +N++ SLS N + EKA + E
Sbjct: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS------NEVNEKAKKLVEME 654
Query: 891 SESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
E K +++R L+ L+ + + Q + ++ ++++ + + ++ I + + N+
Sbjct: 655 REHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQT 714
Query: 950 YEKNIEYVTQLEAQLQEYKNN--IENLNMNV-----EELNKMNLELIDKHVQKQQTQSPD 1002
+K IE V L+E +N IE N V E++ K + +ID +K +
Sbjct: 715 LQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK 774
Query: 1003 YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
YTE+ + E+ KL +++ L + +++ +S + + +L +++
Sbjct: 775 YTEKKL-EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIA-LKSNIVELKKQLSELKK 832
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT--EGMIISSTIEP 1120
+ +++ N L+ ++ Q +K +E K+T + KT E + + E
Sbjct: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 892
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET 1180
++ + + + Q + E+I L E AK+++ L + K+ +
Sbjct: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYIS----LAEHEAKMSS-LSQSMRKV---QD 944
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAEL- 1238
N E+ + QE+I L ++++ E D + + + I S + +R F+ E
Sbjct: 945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE 1004
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQN 1297
K L+++ + +E E++ K ++ + ++Q +++T I + E +L
Sbjct: 1005 LKDQLSEQTQKYSVSEEEVKKNKQE-NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSR 1063
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
K + + L++L +KY +V N ++ ++ +E L + +
Sbjct: 1064 KTDELNKQLKDLSQKYTEVKN----VKEKLVEENAKQTSEILAVQNLLQKQHVPLE-QVE 1118
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
+ K+ +I N+ EE +++ + + + + L L++K++
Sbjct: 1119 ALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA-FE 1177
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
++ +L ++ +E +N +++ + + +++ ++ A+ +L+ E + +
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQN------TKQALKKLETREVVDLSKYKA 1231
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALE---EEV--AKTNEMQTALENQEIE 1532
+S++E T+ SLN+++A LN+ E EEV AK E+ +A + +E+
Sbjct: 1232 TKSDLE------------TQISSLNEKLANLNRKYEEVCEEVLHAKKKEI-SAKDEKELL 1278
Query: 1533 IVTLNDEITNLQNMVRAS---SSKIQKHVSFASDTKQGRDEQLDNTMN 1577
++ EI + + S +++Q+ + ++ + +D ++ +N
Sbjct: 1279 HFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN 1326
Score = 58.4 bits (135), Expect = 2e-07
Identities = 139/705 (19%), Positives = 279/705 (39%), Gaps = 53/705 (7%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEY 956
T ++D E N+K EHQ I + E EDL+ Q E I KV + + N E
Sbjct: 278 THMQD-EVNVKSHQREHQN-IQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 335
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ + L+ + +++L E+ ++ +L I+ + + D+ + N+
Sbjct: 336 M--VADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKED 393
Query: 1017 LLKQKDEEIIALNQKINNAQVSYM---SMVSDYESKLAQFTTKLEN--MEEEMQRVSKQL 1071
+L ++ + +A +Q + ++M SM+ E L T+ EN +++E++ +
Sbjct: 394 MLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 453
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+KQ +LQ E ++ E K L E K + I+ + D +V
Sbjct: 454 ESAKQDRLKLQ---NELAHKVAECKA--LALECERVKEDS---DEQIKQLEDALKDVQKR 505
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
Q + F+ + L ++A N L E QL+ L + G
Sbjct: 506 MYESEGKVK----QMQTHFLALKEHLTSEAASGNHRLTEELKD--QLKDLKVKYEGASAE 559
Query: 1192 NQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
+ NQ+K +E+ + L+ L+ +S +R K+ E
Sbjct: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE-------KKGRKVTEM 612
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ-NKLQDKEEHLR 1307
+ Q E ++ LS K+E + S+ + E+ K+V ME+ ++++ + L
Sbjct: 613 EGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE 672
Query: 1308 NLQEKYADVI--NQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR---TENQSYKQM 1362
N++ K A + + E ++S +E + ++ +N+ K+
Sbjct: 673 NVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 732
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+ + LK S ++D K+L++T + K E+ +K
Sbjct: 733 AHNLTIEMKNHYVPLKVSEDMKKSHDAI----IDDLNRKLLDVTQKYTEKKLEM-EKLLL 787
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDL---TYEKESELAILRLKMHENANHYETMQKE 1479
+L++ E V ++EK I L E + +L+ L+ K E+ + E
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 1480 -SEIERVKLIEELNVKITESV--SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
+ ++++ + + VK E V +LN +A+ N+ L + K ++ + + L
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL 907
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
+ N QN ++A + +H + S Q + D+ N E+L
Sbjct: 908 KRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS--NAEIL 950
>AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein.
Length = 1416
Score = 113 bits (273), Expect = 4e-24
Identities = 188/891 (21%), Positives = 396/891 (44%), Gaps = 90/891 (10%)
Query: 476 NEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
+E A +L +EL D++KD+ V K + A ++ +L ++I N+ +++ +
Sbjct: 529 SEAASGNHRLTEELKDQLKDLKV-----KYEGASAEVGKLRNQI-KQNEMIVEEFKRDEG 582
Query: 536 KL----KQMQKTIDNFSKVSD-SNKEIVRLTEELHHLSQKVA-ELEEEK-GNLQLHLVDY 588
KL K++QK + + +++ + + LS K+A + EK N++ L
Sbjct: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSL--- 639
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL--HILQQKYDEVEDKLAD 646
S + E KK++EME E L I L+ + ++ +L H+ +++++V+ +L
Sbjct: 640 -SNEVNEK--AKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Query: 647 ISQLQSDQVCS-EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
S ++ +K+ L+++I+ + K L NL ++ + Y +K E+ K+
Sbjct: 697 KSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 756
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLY- 763
+ + ++ +D+T K + E LL + ++ S+++T F + + E+++
Sbjct: 757 HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF-VPPEKHEKEIIA 815
Query: 764 ----IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
I ++ +LS+ K + +E I + +L++ Y+ K + T+
Sbjct: 816 LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS--NQYVPVKTHEEVKMTL- 872
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
D L L+D V+K+ +I E +++ KN+IL +NL+ + + ++ Y +L
Sbjct: 873 NDTLAKTNRELLD----VKKKFEDINQEFVKIKDKNEIL---KRNLENTQNQIKAEYISL 925
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQI 936
E + K Q ++ +N ++ E TL I +KKE++ ++ +
Sbjct: 926 AEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY 985
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
+ ++ + E QL Q Q+Y + E + N +E +K+ E+ +QK
Sbjct: 986 APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKD 1043
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
D T I + +++ L +K +E LN+++ + Y + V + + KL +
Sbjct: 1044 LR---DKT-VLIEKSHEMERALSRKTDE---LNKQLKDLSQKY-TEVKNVKEKLVE---- 1091
Query: 1057 LENMEEEMQRVSKQLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI- 1113
EN ++ + ++ Q L KQH E+++ L + + I+ LKE + + K + +
Sbjct: 1092 -ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
Query: 1114 -ISSTIE-------PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN 1165
+ +E P+++ + L+ +EEE Q + E+ +KL
Sbjct: 1151 KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES--QNK---MEEVSKLQ 1205
Query: 1166 TELQECYTKIIQLETLN-TELTGHDVVNQE---QINQLKSKLEQLNTENDNLLSTVAELR 1221
+E+Q + +LET +L+ + + QI+ L KL LN + + + V +
Sbjct: 1206 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQRE---------ADFQKTEHELRVQLSAFESKYEQLL 1272
SA D++ + ++ Q+E + Q+ E Q+ A ++K +LL
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
Query: 1273 DSVQSSTQE---ETNKIVTMEQVTSLQNKLQDKEEH-LRNLQEKYADVINQ 1319
+ V+ Q + T T Q++L D +H +++L+++ AD Q
Sbjct: 1326 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
Score = 98.3 bits (234), Expect = 2e-19
Identities = 182/937 (19%), Positives = 395/937 (42%), Gaps = 76/937 (8%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+E + L L+VK + + L+ +I + + I+E +
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR--FEISL 269
+ +++ K+ E ME + K+ +L I ++ +N++ E A+ E+
Sbjct: 600 MEREKKGRKVTE----MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
Query: 270 EHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
EH K E+ Q K E + K+ +E+K +TELT K +
Sbjct: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKP--EEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
L+ ++ NK L+ + + E K P K + + + + ++
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDM------KKSHDAIIDDLNRK 767
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+ + T+KK+ E+ KL + SL+KD+ E V + L
Sbjct: 768 LLDVTQKYTEKKL---EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELK 824
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSA 508
QL ++ E IH T +E+ N + Q + + ++E+K + + D + K
Sbjct: 825 KQLSELKKKCGEDQEKIHALT-SENTNLKKMMSNQYVPVKTHEEVK-MTLNDTLAK---T 879
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLS 568
++ + + + N+ +K+K +++ + ++ T +++ + ++ LS
Sbjct: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT---QNQIKAEYISLAEHEAKMSSLS 936
Query: 569 QKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
Q + ++++ + L +Y G+ ++ ++ + +T + I + K+ +
Sbjct: 937 QSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV----KYAPIV 989
Query: 629 ELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKL 687
++K+ E +L D +S+ SE + +++ D L KKE+ + ++L+
Sbjct: 990 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL---KKEIFTLQKDLR- 1045
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
DK L ++E + K ++ DL+ K ++ + + E L + N ++ S+I
Sbjct: 1046 DKTVLIEKSHEME---RALSRKTDELNKQLKDLSQKYTEV--KNVKEKLVEENAKQTSEI 1100
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+ +Q++ + +E +E+ I L+E + M+ R Y E++ L
Sbjct: 1101 ---LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ-RCYEKEQQTVTKLHQLL 1156
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
E QK S LA + EK++ I+ +E ++++Q +EE LQ
Sbjct: 1157 ENQKNSSV----------PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1206
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTLIVQ----K 921
+ + +Q L E DL++ ++TK +TQ+ L L + +++ + + K
Sbjct: 1207 EVQNTKQALKKL-ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 922 KKEI--EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
KKEI +D + + IE I+D+K E+ +K++ +T+L+ ++QE IE + +
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
EL L +++ Q S T N + + L+ ++ +L Q++ +A +
Sbjct: 1323 EL----LNDVERLKQALNGLS-QLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQH 1377
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
+++ Y + L + +M+E++Q Q++ +Q
Sbjct: 1378 QEVIAIYRTHL--LSAAQGHMDEDVQEALLQIIQMRQ 1412
Score = 93.1 bits (221), Expect = 8e-18
Identities = 209/1128 (18%), Positives = 482/1128 (42%), Gaps = 98/1128 (8%)
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH---KLKLKQMQKTIDNFSKVSDSNKE 556
D++ LK+A E T E+ ++ + H ++ +K Q+ N + N++
Sbjct: 247 DILTLLKTASEN-TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENED 305
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHL---VDYDSGRMIESDVYKKMIEM-ENLAETR 612
L E L + Q+ L ++ LQL L V E + K ++ E E
Sbjct: 306 ---LKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEES 362
Query: 613 LKAISLLESQKFDLVQELHILQQKY--DEVEDKLADISQL-QSDQVCSEIK-SVHLEEQ- 667
L+ I L++ +F + H+ + + ED L Q+ +D C+ H++ +
Sbjct: 363 LRTIEALKN-RFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 668 -IDALSASKKELALVIEN--LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+ L S EN LK + E + + + D+ + N+L + + E L +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALEC 481
Query: 725 EKM---SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI-ENIESELSKYKSRICR 780
E++ S E+I +L + + Q ++ G ++Q L + E++ SE + R+
Sbjct: 482 ERVKEDSDEQIKQLEDALK-DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE 540
Query: 781 -LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE- 838
L++ + ++ + + +L + +++ + E+ E +L+ L + E
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
Query: 839 ------KQLLEIEHENKELQKKNQILL--EENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+++ E+E + KEL K + + E+ +N++ SLS N + EKA + E
Sbjct: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS------NEVNEKAKKLVEME 654
Query: 891 SESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
E K +++R L+ L+ + + Q + ++ ++++ + + ++ I + + N+
Sbjct: 655 REHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQT 714
Query: 950 YEKNIEYVTQLEAQLQEYKNN--IENLNMNV-----EELNKMNLELIDKHVQKQQTQSPD 1002
+K IE V L+E +N IE N V E++ K + +ID +K +
Sbjct: 715 LQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK 774
Query: 1003 YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
YTE+ + E+ KL +++ L + +++ +S + + +L +++
Sbjct: 775 YTEKKL-EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIA-LKSNIVELKKQLSELKK 832
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT--EGMIISSTIEP 1120
+ +++ N L+ ++ Q +K +E K+T + KT E + + E
Sbjct: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 892
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET 1180
++ + + + Q + E+I L E AK+++ L + K+ +
Sbjct: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYIS----LAEHEAKMSS-LSQSMRKV---QD 944
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAEL- 1238
N E+ + QE+I L ++++ E D + + + I S + +R F+ E
Sbjct: 945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE 1004
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV-TMEQVTSLQN 1297
K L+++ + +E E++ K ++ + ++Q +++T I + E +L
Sbjct: 1005 LKDQLSEQTQKYSVSEEEVKKNKQE-NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSR 1063
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
K + + L++L +KY +V N ++ ++ +E L + +
Sbjct: 1064 KTDELNKQLKDLSQKYTEVKN----VKEKLVEENAKQTSEILAVQNLLQKQHVPLE-QVE 1118
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
+ K+ +I N+ EE +++ + + + + L L++K++
Sbjct: 1119 ALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA-FE 1177
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
++ +L ++ +E +N +++ + + +++ ++ A+ +L+ E + +
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQN------TKQALKKLETREVVDLSKYKA 1231
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALE---EEV--AKTNEMQTALENQEIE 1532
+S++E T+ SLN+++A LN+ E EEV AK E+ +A + +E+
Sbjct: 1232 TKSDLE------------TQISSLNEKLANLNRKYEEVCEEVLHAKKKEI-SAKDEKELL 1278
Query: 1533 IVTLNDEITNLQNMVRAS---SSKIQKHVSFASDTKQGRDEQLDNTMN 1577
++ EI + + S +++Q+ + ++ + +D ++ +N
Sbjct: 1279 HFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN 1326
Score = 58.4 bits (135), Expect = 2e-07
Identities = 139/705 (19%), Positives = 279/705 (39%), Gaps = 53/705 (7%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEY 956
T ++D E N+K EHQ I + E EDL+ Q E I KV + + N E
Sbjct: 278 THMQD-EVNVKSHQREHQN-IQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 335
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ + L+ + +++L E+ ++ +L I+ + + D+ + N+
Sbjct: 336 M--VADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKED 393
Query: 1017 LLKQKDEEIIALNQKINNAQVSYM---SMVSDYESKLAQFTTKLEN--MEEEMQRVSKQL 1071
+L ++ + +A +Q + ++M SM+ E L T+ EN +++E++ +
Sbjct: 394 MLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 453
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+KQ +LQ E ++ E K L E K + I+ + D +V
Sbjct: 454 ESAKQDRLKLQ---NELAHKVAECKA--LALECERVKEDS---DEQIKQLEDALKDVQKR 505
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
Q + F+ + L ++A N L E QL+ L + G
Sbjct: 506 MYESEGKVK----QMQTHFLALKEHLTSEAASGNHRLTEELKD--QLKDLKVKYEGASAE 559
Query: 1192 NQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
+ NQ+K +E+ + L+ L+ +S +R K+ E
Sbjct: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE-------KKGRKVTEM 612
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ-NKLQDKEEHLR 1307
+ Q E ++ LS K+E + S+ + E+ K+V ME+ ++++ + L
Sbjct: 613 EGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE 672
Query: 1308 NLQEKYADVI--NQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR---TENQSYKQM 1362
N++ K A + + E ++S +E + ++ +N+ K+
Sbjct: 673 NVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 732
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+ + LK S ++D K+L++T + K E+ +K
Sbjct: 733 AHNLTIEMKNHYVPLKVSEDMKKSHDAI----IDDLNRKLLDVTQKYTEKKLEM-EKLLL 787
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDL---TYEKESELAILRLKMHENANHYETMQKE 1479
+L++ E V ++EK I L E + +L+ L+ K E+ + E
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 1480 -SEIERVKLIEELNVKITESV--SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
+ ++++ + + VK E V +LN +A+ N+ L + K ++ + + L
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL 907
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
+ N QN ++A + +H + S Q + D+ N E+L
Sbjct: 908 KRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS--NAEIL 950
>M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 113 bits (272), Expect = 5e-24
Identities = 220/1164 (18%), Positives = 478/1164 (41%), Gaps = 85/1164 (7%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 741 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 800
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 801 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 856
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAE 610
RL E L L +K+ L +EK +LQL + + ++I+ + E
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 611 TRLKAISLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
++K ++ + ++ EL ++K DE + DI L+ E + E ++
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 670 ALSASKKELALVIENLKLDKEQL----YGTIKDL--ENDKEDIMNKLQNYIQENM-DLTD 722
L+ L +I L +K+ L + DL E DK + + K + +++ + DL
Sbjct: 977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK--IQERDLYIENIESELSKYKSRICR 780
LE+ ++ AK E K+ + +D + Q+ D ++ + EL+ +RI
Sbjct: 1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED 1096
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEK 839
+ + ++ + L+ + ++L L+ ++ A ++ +L L + + +
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Query: 840 QLLEIEHENK---ELQKKNQILLEEN-QNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
++IE K E QK + L E Q+ + + ++H +++ E + D + K
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + + + L +T + +I K +LE T +E + + + E+ ++++
Sbjct: 1217 LEKEKSEFKLELDDVTSNMEQIIKAK----ANLEKMCRT-LEDQMNEHRSKAEETQRSVN 1271
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+T A+LQ L+ ++E + +L + Q Q D Q E+ N
Sbjct: 1272 DLTSQRAKLQTENG---ELSRQLDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKN 1327
Query: 1016 AL---LKQKDEEIIALNQKI---NNAQVSYMSMVSDYESKLAQFTTKLE----NMEEEMQ 1065
AL L+ + L ++ A+ ++S S++AQ+ TK E EE++
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
K+L Q EE V + + L++TK + I E +++ +E + A
Sbjct: 1388 EAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMVD--VERSNAAA 1439
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKIIQ-LETL 1181
+D K Q+ EE E Q+++ L+TE L+ Y + ++ LET
Sbjct: 1440 AALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Query: 1182 NTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
E + ++ EQ+ + +L L + EL+S++ A E ++
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
Query: 1239 WKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-NKIVTMEQVTSL 1295
+ L Q +A+ ++ E ++ + + +++DS+Q+S ET ++ + +
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
+ L + E L + A+ Q++ L+S ++D ++ R
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1678
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
N +++E + Q ++S RV ++ L +Q + D++
Sbjct: 1679 NLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAD 1733
Query: 1416 IYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYET 1475
+ Q E + + + E ++ + + E+L E+++ + R+K + +
Sbjct: 1734 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
Query: 1476 MQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTA 1525
+ E E++ K +++L ++ E + K+ AE K + + + E+
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1526 LENQEIEIVTLNDEITNLQNMVRA 1549
E ++ L D + LQ V+A
Sbjct: 1854 TEEDRKNLLRLQDLVDKLQLKVKA 1877
Score = 111 bits (268), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELESERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1616 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTE 1696
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 968
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDLSREL 1143
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1381 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1426
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1427 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1663
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1781
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1840 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1895
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1896 -FRKVQHEL 1903
Score = 89.8 bits (213), Expect = 7e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 915 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 1032 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDLSRELEEISERL 1150
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 1151 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 1202
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 1203 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 1317
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1376
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1616 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1662
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1720
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1721 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1776
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1636 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1811 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1866 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1920
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1921 RA--KSRDIGTKGLNEE 1935
>M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 113 bits (272), Expect = 5e-24
Identities = 220/1164 (18%), Positives = 478/1164 (41%), Gaps = 85/1164 (7%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 741 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 800
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 801 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 856
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAE 610
RL E L L +K+ L +EK +LQL + + ++I+ + E
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 611 TRLKAISLLESQKFDLVQELHILQQKY-DEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
++K ++ + ++ EL ++K DE + DI L+ E + E ++
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 670 ALSASKKELALVIENLKLDKEQL----YGTIKDL--ENDKEDIMNKLQNYIQENM-DLTD 722
L+ L +I L +K+ L + DL E DK + + K + +++ + DL
Sbjct: 977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK--IQERDLYIENIESELSKYKSRICR 780
LE+ ++ AK E K+ + +D + Q+ D ++ + EL+ +RI
Sbjct: 1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED 1096
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEK 839
+ + ++ + L+ + ++L L+ ++ A ++ +L L + + +
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Query: 840 QLLEIEHENK---ELQKKNQILLEEN-QNLQISLSDMQQHYNALVEKANRTDLAESESTK 895
++IE K E QK + L E Q+ + + ++H +++ E + D + K
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + + + L +T + +I K +LE T +E + + + E+ ++++
Sbjct: 1217 LEKEKSEFKLELDDVTSNMEQIIKAK----ANLEKMCRT-LEDQMNEHRSKAEETQRSVN 1271
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+T A+LQ L+ ++E + +L + Q Q D Q E+ N
Sbjct: 1272 DLTSQRAKLQTENG---ELSRQLDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKN 1327
Query: 1016 AL---LKQKDEEIIALNQKI---NNAQVSYMSMVSDYESKLAQFTTKLE----NMEEEMQ 1065
AL L+ + L ++ A+ ++S S++AQ+ TK E EE++
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
K+L Q EE V + + L++TK + I E +++ +E + A
Sbjct: 1388 EAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMVD--VERSNAAA 1439
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKIIQ-LETL 1181
+D K Q+ EE E Q+++ L+TE L+ Y + ++ LET
Sbjct: 1440 AALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Query: 1182 NTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
E + ++ EQ+ + +L L + EL+S++ A E ++
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
Query: 1239 WKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-NKIVTMEQVTSL 1295
+ L Q +A+ ++ E ++ + + +++DS+Q+S ET ++ + +
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
+ L + E L + A+ Q++ L+S ++D ++ R
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1678
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
N +++E + Q ++S RV ++ L +Q + D++
Sbjct: 1679 NLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAD 1733
Query: 1416 IYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYET 1475
+ Q E + + + E ++ + + E+L E+++ + R+K + +
Sbjct: 1734 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
Query: 1476 MQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTA 1525
+ E E++ K +++L ++ E + K+ AE K + + + E+
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1526 LENQEIEIVTLNDEITNLQNMVRA 1549
E ++ L D + LQ V+A
Sbjct: 1854 TEEDRKNLLRLQDLVDKLQLKVKA 1877
Score = 111 bits (268), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELESERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1616 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTE 1696
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 968
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDLSREL 1143
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1381 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1426
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1427 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1663
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1781
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1840 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1895
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1896 -FRKVQHEL 1903
Score = 89.8 bits (213), Expect = 7e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 915 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 1032 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDLSRELEEISERL 1150
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 1151 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 1202
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 1203 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 1317
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1376
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1616 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1662
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1720
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1721 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1776
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1636 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1811 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1866 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1920
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1921 RA--KSRDIGTKGLNEE 1935
>EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 113 bits (272), Expect = 5e-24
Identities = 228/1175 (19%), Positives = 487/1175 (41%), Gaps = 107/1175 (9%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 741 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 800
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 801 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 856
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQL-------HLVDYDS--GRMIESDVY-- 599
RL E L L +K+ L +EK +LQL +L D + ++I++ +
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
K+ EM E + + L ++K L E L++ D++E LA + + + +++
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK-EKHATENKV 975
Query: 660 KSV-----HLEEQIDALSASKKEL----ALVIENLKLDKEQLYGTIK---DLENDKEDIM 707
K++ L+E I L+ KK L +++L+ +++++ K LE +D+
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 708 NKLQNYIQENMDL---TDKLE---KMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQ 758
L+ + MDL KLE K++ E I +L +++ + K ++A+I+
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ ++ +L + ++RI LEE + R +E+ L L+E SE +
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE----ISE-RL 1150
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+E + + M+ R E Q + + E LQ + ++ S++++ + +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDN 1209
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
L + E E ++++ +L D+ SN+++I L + + +ED E ++ E
Sbjct: 1210 LQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEE 1265
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
R L + K +L QL E + I L + LE + + ++++
Sbjct: 1266 TQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG-KLTYTQQLEDLKRQLEEEVK 1324
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + L +Q +EE A+ ++S S++AQ+ TK E
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEE--------TEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 1059 ----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
EE++ K+L Q EE V + + L++TK + I E +++
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMV 1430
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQEC 1171
+E + A +D K Q+ EE E Q+++ L+TE L+
Sbjct: 1431 D--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 1172 YTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y + ++ LET E + ++ EQ+ + +L L + EL+S++ A
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1547
Query: 1228 VDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-N 1284
E ++ + L Q +A+ ++ E ++ + + +++DS+Q+S ET +
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
+ + ++ L + E L + A+ Q++ L+S ++D ++
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 1345 XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
R N +++E + Q ++S RV ++
Sbjct: 1668 KENIAIVERRNNLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRL 1464
L +Q + D+++ Q E + + + E ++ + + E+L E+++ + R+
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782
Query: 1465 KMHENANHYETMQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEE 1514
K + + + E E++ K +++L ++ E + K+ AE K + +
Sbjct: 1783 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
+ E+ E ++ L D + LQ V+A
Sbjct: 1843 SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1877
Score = 111 bits (267), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1616 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTE 1696
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 968
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1381 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1426
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1427 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1663
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1781
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1840 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1895
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1896 -FRKVQHEL 1903
Score = 90.2 bits (214), Expect = 5e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 915 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 1032 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 1151 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 1202
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 1203 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 1317
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1376
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1616 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1662
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1720
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1721 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1776
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1636 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1811 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1866 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1920
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1921 RA--KSRDIGTKGLNEE 1935
>BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 113 bits (272), Expect = 5e-24
Identities = 228/1175 (19%), Positives = 487/1175 (41%), Gaps = 107/1175 (9%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 741 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 800
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 801 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 856
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQL-------HLVDYDS--GRMIESDVY-- 599
RL E L L +K+ L +EK +LQL +L D + ++I++ +
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
K+ EM E + + L ++K L E L++ D++E LA + + + +++
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK-EKHATENKV 975
Query: 660 KSV-----HLEEQIDALSASKKEL----ALVIENLKLDKEQLYGTIK---DLENDKEDIM 707
K++ L+E I L+ KK L +++L+ +++++ K LE +D+
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 708 NKLQNYIQENMDL---TDKLE---KMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQ 758
L+ + MDL KLE K++ E I +L +++ + K ++A+I+
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ ++ +L + ++RI LEE + R +E+ L L+E SE +
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE----ISE-RL 1150
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+E + + M+ R E Q + + E LQ + ++ S++++ + +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDN 1209
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
L + E E ++++ +L D+ SN+++I L + + +ED E ++ E
Sbjct: 1210 LQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEE 1265
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
R L + K +L QL E + I L + LE + + ++++
Sbjct: 1266 TQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG-KLTYTQQLEDLKRQLEEEVK 1324
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + L +Q +EE A+ ++S S++AQ+ TK E
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEE--------TEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 1059 ----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
EE++ K+L Q EE V + + L++TK + I E +++
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMV 1430
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQEC 1171
+E + A +D K Q+ EE E Q+++ L+TE L+
Sbjct: 1431 D--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 1172 YTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y + ++ LET E + ++ EQ+ + +L L + EL+S++ A
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1547
Query: 1228 VDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-N 1284
E ++ + L Q +A+ ++ E ++ + + +++DS+Q+S ET +
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
+ + ++ L + E L + A+ Q++ L+S ++D ++
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 1345 XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
R N +++E + Q ++S RV ++
Sbjct: 1668 KENIAIVERRNNLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRL 1464
L +Q + D+++ Q E + + + E ++ + + E+L E+++ + R+
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782
Query: 1465 KMHENANHYETMQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEE 1514
K + + + E E++ K +++L ++ E + K+ AE K + +
Sbjct: 1783 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
+ E+ E ++ L D + LQ V+A
Sbjct: 1843 SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1877
Score = 111 bits (267), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1616 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTE 1696
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 968
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1381 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1426
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1427 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1663
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1781
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1840 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1895
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1896 -FRKVQHEL 1903
Score = 90.2 bits (214), Expect = 5e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 915 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 1032 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 1151 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 1202
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 1203 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 1317
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1376
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1616 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1662
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1720
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1721 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1776
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1636 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1811 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1866 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1920
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1921 RA--KSRDIGTKGLNEE 1935
>BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 113 bits (272), Expect = 5e-24
Identities = 228/1175 (19%), Positives = 487/1175 (41%), Gaps = 107/1175 (9%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 741 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 800
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 801 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 856
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQL-------HLVDYDS--GRMIESDVY-- 599
RL E L L +K+ L +EK +LQL +L D + ++I++ +
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
K+ EM E + + L ++K L E L++ D++E LA + + + +++
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK-EKHATENKV 975
Query: 660 KSV-----HLEEQIDALSASKKEL----ALVIENLKLDKEQLYGTIK---DLENDKEDIM 707
K++ L+E I L+ KK L +++L+ +++++ K LE +D+
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 708 NKLQNYIQENMDL---TDKLE---KMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQ 758
L+ + MDL KLE K++ E I +L +++ + K ++A+I+
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ ++ +L + ++RI LEE + R +E+ L L+E SE +
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE----ISE-RL 1150
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+E + + M+ R E Q + + E LQ + ++ S++++ + +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDN 1209
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
L + E E ++++ +L D+ SN+++I L + + +ED E ++ E
Sbjct: 1210 LQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEE 1265
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
R L + K +L QL E + I L + LE + + ++++
Sbjct: 1266 TQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG-KLTYTQQLEDLKRQLEEEVK 1324
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + L +Q +EE A+ ++S S++AQ+ TK E
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEE--------TEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 1059 ----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
EE++ K+L Q EE V + + L++TK + I E +++
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMV 1430
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQEC 1171
+E + A +D K Q+ EE E Q+++ L+TE L+
Sbjct: 1431 D--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 1172 YTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y + ++ LET E + ++ EQ+ + +L L + EL+S++ A
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1547
Query: 1228 VDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-N 1284
E ++ + L Q +A+ ++ E ++ + + +++DS+Q+S ET +
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
+ + ++ L + E L + A+ Q++ L+S ++D ++
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 1345 XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
R N +++E + Q ++S RV ++
Sbjct: 1668 KENIAIVERRNNLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRL 1464
L +Q + D+++ Q E + + + E ++ + + E+L E+++ + R+
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782
Query: 1465 KMHENANHYETMQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEE 1514
K + + + E E++ K +++L ++ E + K+ AE K + +
Sbjct: 1783 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
+ E+ E ++ L D + LQ V+A
Sbjct: 1843 SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1877
Score = 111 bits (267), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1616 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTE 1696
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 968
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1381 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1426
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1427 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1663
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1781
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1840 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1895
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1896 -FRKVQHEL 1903
Score = 90.2 bits (214), Expect = 5e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 915 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 1032 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 1151 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 1202
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 1203 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 1317
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1376
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1616 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1662
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1720
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1721 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1776
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1636 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1811 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1866 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1920
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1921 RA--KSRDIGTKGLNEE 1935
>AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypeptide 7,
cardiac muscle, beta variant protein.
Length = 1574
Score = 113 bits (272), Expect = 5e-24
Identities = 228/1175 (19%), Positives = 487/1175 (41%), Gaps = 107/1175 (9%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 380 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 439
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 440 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 495
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQL-------HLVDYDS--GRMIESDVY-- 599
RL E L L +K+ L +EK +LQL +L D + ++I++ +
Sbjct: 496 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 555
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
K+ EM E + + L ++K L E L++ D++E LA + + + +++
Sbjct: 556 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK-EKHATENKV 614
Query: 660 KSV-----HLEEQIDALSASKKEL----ALVIENLKLDKEQLYGTIK---DLENDKEDIM 707
K++ L+E I L+ KK L +++L+ +++++ K LE +D+
Sbjct: 615 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 674
Query: 708 NKLQNYIQENMDL---TDKLE---KMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQ 758
L+ + MDL KLE K++ E I +L +++ + K ++A+I+
Sbjct: 675 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 734
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ ++ +L + ++RI LEE + R +E+ L L+E SE +
Sbjct: 735 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE----ISE-RL 789
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+E + + M+ R E Q + + E LQ + ++ S++++ + +
Sbjct: 790 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDN 848
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
L + E E ++++ +L D+ SN+++I L + + +ED E ++ E
Sbjct: 849 LQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEE 904
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
R L + K +L QL E + I L + LE + + ++++
Sbjct: 905 TQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG-KLTYTQQLEDLKRQLEEEVK 963
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + L +Q +EE A+ ++S S++AQ+ TK E
Sbjct: 964 AKNALAHALQSARHDCDLLREQYEEE--------TEAKAELQRVLSKANSEVAQWRTKYE 1015
Query: 1059 ----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
EE++ K+L Q EE V + + L++TK + I E +++
Sbjct: 1016 TDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMV 1069
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQEC 1171
+E + A +D K Q+ EE E Q+++ L+TE L+
Sbjct: 1070 D--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNA 1126
Query: 1172 YTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y + ++ LET E + ++ EQ+ + +L L + EL+S++ A
Sbjct: 1127 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1186
Query: 1228 VDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-N 1284
E ++ + L Q +A+ ++ E ++ + + +++DS+Q+S ET +
Sbjct: 1187 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1246
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
+ + ++ L + E L + A+ Q++ L+S ++D ++
Sbjct: 1247 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1306
Query: 1345 XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
R N +++E + Q ++S RV ++
Sbjct: 1307 KENIAIVERRNNLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1361
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRL 1464
L +Q + D+++ Q E + + + E ++ + + E+L E+++ + R+
Sbjct: 1362 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1421
Query: 1465 KMHENANHYETMQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEE 1514
K + + + E E++ K +++L ++ E + K+ AE K + +
Sbjct: 1422 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1481
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
+ E+ E ++ L D + LQ V+A
Sbjct: 1482 SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1516
Score = 111 bits (267), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 409 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 468
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 469 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 526
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 527 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 582
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 583 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 641
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 642 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 699
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 700 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 757
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 758 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 809
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 810 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 865
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 866 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 922
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 923 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 982
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 983 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1026
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1027 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1080
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1081 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1135
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1136 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1195
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1196 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1254
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1255 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1310
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1311 AIVERRNNLLQAELEELRAVVEQTE 1335
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 489 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 548
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 549 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 607
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 608 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 664
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 665 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 722
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 723 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 782
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 783 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 842
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 843 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 902
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 903 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 959
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 960 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1019
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1020 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1065
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1066 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1124
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1125 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1184
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1185 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1244
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1245 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1302
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1303 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1362
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1363 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1420
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1421 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1478
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1479 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1534
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1535 -FRKVQHEL 1542
Score = 90.2 bits (214), Expect = 5e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 494 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 553
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 554 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 611
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 612 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 670
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 671 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 729
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 730 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 789
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 790 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 841
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 842 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 899
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 900 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 956
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 957 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1015
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1016 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1075
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1076 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1135
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1136 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1195
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1196 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1254
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1255 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1301
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1302 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1359
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1360 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1415
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1416 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1475
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1476 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1535
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1536 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1572
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 711 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 770
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 771 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 826
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 827 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 885
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 886 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 939
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 940 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 993
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 994 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1045
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1046 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1105
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1106 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1162
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1163 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1220
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1221 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1274
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1275 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1329
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1330 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1389
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1390 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1449
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1450 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1504
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1505 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1559
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1560 RA--KSRDIGTKGLNEE 1574
>AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 112 bits (270), Expect = 9e-24
Identities = 228/1175 (19%), Positives = 486/1175 (41%), Gaps = 107/1175 (9%)
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIH-----VGTNTEDVNE-IAKVQEQLKQELNDEIKDVN 497
G + L++ L ++H Q+ G + + +G E +E ++++ +++ + + +
Sbjct: 741 GAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARME 800
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
K L+E+ S + Q N KN +K K+K + K+ + +++ +E
Sbjct: 801 YKKLLERRDSL--LVIQWNIRAFMGVKNWPWMKLY--FKIKPLLKSAEREKEMASMKEEF 856
Query: 558 VRLTEELH-------HLSQKVAELEEEKGNLQL-------HLVDYDS--GRMIESDVY-- 599
RL E L L +K+ L +EK +LQL +L D + ++I++ +
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
K+ EM E + + L ++K L E L++ D++E LA + + + +++
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK-EKHATENKV 975
Query: 660 KSV-----HLEEQIDALSASKKEL----ALVIENLKLDKEQLYGTIK---DLENDKEDIM 707
K++ L+E I L+ KK L +++L+ +++++ K LE +D+
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 708 NKLQNYIQENMDL---TDKLE---KMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQ 758
L+ + MDL KLE K++ E I +L +++ + K ++A+I+
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+ ++ +L + ++RI LEE + R +E+ L L+E SE +
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE----ISE-RL 1150
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+E + M+ R E Q + + E LQ + ++ S++++ + +
Sbjct: 1151 EEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDN 1209
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
L + E E ++++ +L D+ SN+++I L + + +ED E ++ E
Sbjct: 1210 LQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEE 1265
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
R L + K +L QL E + I L + LE + + ++++
Sbjct: 1266 TQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG-KLTYTQQLEDLKRQLEEEVK 1324
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ + + L +Q +EE A+ ++S S++AQ+ TK E
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEE--------TEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 1059 ----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
EE++ K+L Q EE V + + L++TK + I E +++
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKCSSLEKTKHRLQNEI---EDLMV 1430
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQEC 1171
+E + A +D K Q+ EE E Q+++ L+TE L+
Sbjct: 1431 D--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 1172 YTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y + ++ LET E + ++ EQ+ + +L L + EL+S++ A
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1547
Query: 1228 VDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET-N 1284
E ++ + L Q +A+ ++ E ++ + + +++DS+Q+S ET +
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX 1344
+ + ++ L + E L + A+ Q++ L+S ++D ++
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 1345 XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
R N +++E + Q ++S RV ++
Sbjct: 1668 KENIAIVERRNNLLQAELEE-----LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 1405 LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRL 1464
L +Q + D+++ Q E + + + E ++ + + E+L E+++ + R+
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782
Query: 1465 KMHENANHYETMQKESEIERV------KLIEELNVKI----TESVSLNKQVAELNKALEE 1514
K + + + E E++ K +++L ++ E + K+ AE K + +
Sbjct: 1783 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
+ E+ E ++ L D + LQ V+A
Sbjct: 1843 SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1877
Score = 111 bits (268), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 770 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 830 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 887
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 888 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 1002
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 1003 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 1061 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 1118
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 1119 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAE 1170
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 1171 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 1226
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTE 1283
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 1344 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 1387
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 1388 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 1441
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 1442 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 1616 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTE 1696
Score = 95.1 bits (226), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 968
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 1144 EEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 1381 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 1426
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 1427 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 1663
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1781
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1840 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1895
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1896 -FRKVQHEL 1903
Score = 89.8 bits (213), Expect = 7e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 915 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 1032 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 1151 EEAGGATSCQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 1202
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 1203 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 1317
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 1376
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 1616 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 1662
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 1720
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 1721 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1776
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 1132 VEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1187
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ------ 1300
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 1354
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 1467 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 1581
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 1635
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 1636 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1811 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1866 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1920
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1921 RA--KSRDIGTKGLNEE 1935
>AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.7B protein.
Length = 1179
Score = 111 bits (268), Expect = 2e-23
Identities = 208/985 (21%), Positives = 405/985 (41%), Gaps = 72/985 (7%)
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
L +L++ DE ++ Q QS V + ++ L E+ D+L + + +
Sbjct: 14 LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 73
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+LY IK L E ++ + +E L + LEK A + EL K+ Q K
Sbjct: 74 MKLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDL 131
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
Q + A E+D + E K++I +LE + M +R E +L + ++
Sbjct: 132 QLQVQA---EQDNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEEEMNAELTAKKRKL 187
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ SE D+L LA + E ++ + E L + L +E + LQ +
Sbjct: 188 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA- 246
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
QQ + L + ++ + K + Q+ DLE +L++ L K+K DL+
Sbjct: 247 --HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 304
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ I DK+ L+E+ +K + L A++++ + L ++EL + +E +
Sbjct: 305 LT-QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-QARIEEL 362
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
++ ++ ++T ++ KL + L ++ EEI ++ A + M E++
Sbjct: 363 EEELEAERTARA--------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 414
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
+ LE E +Q + K+H + + L EQ D ++ +K+ KL E + K
Sbjct: 415 FQKMRRDLE--EATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQ-KLEKEKSEFKL 470
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTE 1167
E ++S +E + N++ + + EE +RSV L Q AKL TE
Sbjct: 471 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQQAKLQTE 527
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
E ++ + E L ++LT + +Q+ LK +LE+ + L + R
Sbjct: 528 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 587
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+Q E + +A+ Q+ + +++ + +KYE D++Q + + E
Sbjct: 588 REQYEEE---------TEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELE----- 631
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
E L +LQ+ EE + + K + + L++EIED V
Sbjct: 632 --EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA---- 685
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
L + +++ ++ + E ++L +SS ++ +A + LE
Sbjct: 686 ----LDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLE 740
Query: 1408 QLELKDSEIYQKTHEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESEL----- 1459
+ ++ + ++ + T L E E VR+QL + ++ E E+ L
Sbjct: 741 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 800
Query: 1460 AILRLKMHENANHYE----TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ILR ++ N E +K+ E+E+ K L V + SL+ + N+AL +
Sbjct: 801 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKR-NHLRVVDSLQTSLDAETRSRNEALRVK 859
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNT 1575
+M+ L EI++ N Q V++ S ++ D + D+ +N
Sbjct: 860 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 915
Query: 1576 MNKELLDAVPRAELDLAMYMLHQRD 1600
E + + +AEL+ ++ Q +
Sbjct: 916 AIVERRNNLLQAELEELRAVVEQTE 940
Score = 109 bits (261), Expect = 1e-22
Identities = 210/1077 (19%), Positives = 445/1077 (41%), Gaps = 97/1077 (9%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEELH-------HLSQKVAELEEEKGNLQL----- 583
K+K + K+ + +++ +E RL E L L +K+ L +EK +LQL
Sbjct: 79 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 138
Query: 584 --HLVDYDS--GRMIESDVY--KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
+L D + ++I++ + K+ EM E + + L ++K L E L++
Sbjct: 139 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 198
Query: 638 DEVEDKLADISQLQSDQVCSEIKSV-----HLEEQIDALSASKKEL----ALVIENLKLD 688
D++E LA + + + +++K++ L+E I L+ KK L +++L+ +
Sbjct: 199 DDLELTLAKVEK-EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 257
Query: 689 KEQLYGTIK---DLENDKEDIMNKLQNYIQENMDL---TDKLE---KMSAEKISEL---L 736
++++ K LE +D+ L+ + MDL KLE K++ E I +L
Sbjct: 258 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 317
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
+++ + K ++A+I++ ++ +L + ++RI LEE + R +E
Sbjct: 318 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 377
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
+ L L+E SE ++E + + M+ R E Q + + E LQ +
Sbjct: 378 KLRSDLSRELEE----ISE-RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 432
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
++ S++++ + + L + E E ++++ +L D+ SN+++I
Sbjct: 433 AAALRKKHAD-SVAELGEQIDNLQRVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKAN 488
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L + + +ED E ++ E R L + K +L QL E + I L
Sbjct: 489 L-EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQTENGELSRQLDEKEALISQLTR 547
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ LE + + ++++ + + + L +Q +EE A+
Sbjct: 548 G-KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE--------TEAK 598
Query: 1037 VSYMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
++S S++AQ+ TK E EE++ K+L Q EE V + +
Sbjct: 599 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE---AVEAVNAKC 655
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
L++TK + I E +++ +E + A +D K Q+ EE
Sbjct: 656 SSLEKTKHRLQNEI---EDLMVD--VERSNAAAAALDKKQRNFDKILAEWK-QKYEESQS 709
Query: 1153 ERSVLQEQSAKLNTE---LQECYTKIIQ-LETLNTELTG-HDVVNQ--EQINQLKSKLEQ 1205
E Q+++ L+TE L+ Y + ++ LET E + ++ EQ+ + +
Sbjct: 710 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 769
Query: 1206 LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA--QREADFQKTEHELRVQLSA 1263
L L + EL+S++ A E ++ + L Q +A+ ++ E ++
Sbjct: 770 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 829
Query: 1264 FESKYEQLLDSVQSSTQEET-NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
+ + +++DS+Q+S ET ++ + ++ L + E L + A+ Q++
Sbjct: 830 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 889
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSX 1382
L+S ++D ++ R N +++E + Q ++S
Sbjct: 890 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE-----LRAVVEQTERSRK 944
Query: 1383 XXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
RV ++ L +Q + D+++ Q E + + + E ++ +
Sbjct: 945 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1004
Query: 1443 EYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERV------KLIEELNVKI- 1495
+ E+L E+++ + R+K + + + E E++ K +++L ++
Sbjct: 1005 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1064
Query: 1496 ---TESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRA 1549
E + K+ AE K + + + E+ E ++ L D + LQ V+A
Sbjct: 1065 ELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1121
Score = 96.3 bits (229), Expect = 8e-19
Identities = 175/896 (19%), Positives = 387/896 (43%), Gaps = 82/896 (9%)
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV-KSNHKL-- 535
AKV+E + + L DE +++N +L K + E++ ++L +ID + KV K H
Sbjct: 161 AKVKE-MNERLEDE-EEMNA-ELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 217
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN--------LQLHLVD 587
K+K + + + ++ + + +E H + + EE+K N L+ + D
Sbjct: 218 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD 277
Query: 588 YDSG----RMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL----HILQQKYDE 639
+ + + D+ + ++E + ++I LE+ K L + L L
Sbjct: 278 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 337
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL 699
+ED+ A SQLQ + + LEE+++A ++ + +E L+ D L ++++
Sbjct: 338 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK----VEKLRSD---LSRELEEI 390
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID--AKI 757
E+ I+ N + +KM + + E A + HE + + D A++
Sbjct: 391 SERLEEAGGATSVQIEMNKKREAEFQKMRRD-LEE--ATLQHEATAAALRKKHADSVAEL 447
Query: 758 QERDLYIENIESELSKYKSRI-CRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAY 813
E+ ++ ++ +L K KS L++ + ME + +LE+ L + E +
Sbjct: 448 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 507
Query: 814 SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ 873
E ++L ++ A L + + +QL E E +L + ++ ++L+ L +
Sbjct: 508 EETQRSVNDLTSQQAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 567
Query: 874 QHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
+ NAL ++ R D + +Y+ + + ++ L+R+ + + + Q + + E I+
Sbjct: 568 KAKNALAHALQSARHD-CDLLREQYEEE-TEAKAELQRVLSKANSEVAQWRTKYETDAIQ 625
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYV----TQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
++E A + ++ E+ +E V + LE +N IE+L ++VE N
Sbjct: 626 RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 685
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
L K+Q ++ + + + L+ +E +L+ ++ + +Y + E
Sbjct: 686 L-----DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 740
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIP 1107
+ F + +N++EE+ +++QL S + EL+ + ++ + + EL+ E ++
Sbjct: 741 T----FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 796
Query: 1108 KTEGMIISSTIE----------PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVL 1157
EG I+ + +E +++ ++ L+ + E L
Sbjct: 797 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 856
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
+ + K+ +L E ++ + E Q+Q+ L+S L+ + D+ +
Sbjct: 857 RVKK-KMEGDLNEMEIQLSHANRMAAEA-------QKQVKSLQSLLKDTQIQLDDAVRAN 908
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE--HELRVQLSAFESKYEQLLDSV 1275
+L+ +I + V++R L + L + A ++TE +L Q S+ QLL S
Sbjct: 909 DDLKENI-AIVERRN----NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 963
Query: 1276 QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+S + K+ ++ LQ ++++ + RN +EK I ++ E++ E+
Sbjct: 964 NTSLINQKKKMDA--DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1017
Score = 94.7 bits (225), Expect = 2e-18
Identities = 212/1089 (19%), Positives = 449/1089 (41%), Gaps = 96/1089 (8%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEAN-KLLEA---ARFEISLEHSKLAQELEQXXXXX 285
A K+E RL + +E + R LEE LL+ + ++ E LA E+
Sbjct: 94 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 153
Query: 286 XXXXXXXXXLAKQSIEPSCEEKTEIE---EKGSLEIANMTELTKKIELLEHLNCQIRQTN 342
+ + + EE+ E +K LE +EL + I+ LE ++ +
Sbjct: 154 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEK 212
Query: 343 KELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKI 402
ENK+ + E + K L K A + Q + +N T K+
Sbjct: 213 HATENKVKNLTEEMAGLDEIIAK---LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 269
Query: 403 N-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHME 461
+ ++ LE ++ K +D E +++ D + QL+ + +
Sbjct: 270 KLEQQVDDLEGSLEQEKKVRMDLER--AKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 327
Query: 462 GPSLIHVGTNTEDVNEI-AKVQEQLK------QELNDEIK-DVNVKDLIEKLKS----AE 509
L + ED + +++Q++LK +EL +E++ + + +EKL+S
Sbjct: 328 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 387
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---------L 560
E+I++ +E A I++ + + ++M++ ++ + ++ +R L
Sbjct: 388 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 447
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSG--RMIES---------DVYKKMIEMENLA 609
E++ +L + +LE+EK +L L D S ++I++ + +M E + A
Sbjct: 448 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 507
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E ++++ L SQ+ L E L ++ DE E A ISQL ++ + L+ Q++
Sbjct: 508 EETQRSVNDLTSQQAKLQTENGELSRQLDEKE---ALISQLTRGKLTYTQQLEDLKRQLE 564
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+K LA +++ + D + L ++ K ++ L E K E +
Sbjct: 565 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 624
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ EL EE K Q ++QE + +E + ++ S + RL+ I E
Sbjct: 625 QRTEEL------EEAKKKLAQ-----RLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---E 670
Query: 790 DRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
D +ER ++ + L +KQ K +E+ + +E + L R + +L +++
Sbjct: 671 DLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 729
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLR 901
+ +E + + EN+NLQ +SD+ + + + + + E+E + Q+ L
Sbjct: 730 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 789
Query: 902 DLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ E++L+ + Q Q K EIE E + ++E A R+ + + + +++ T
Sbjct: 790 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 849
Query: 959 QLEAQLQEYKNNIE----NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ + K +E + + + N+M E K V+ Q+ D T+ +++ +
Sbjct: 850 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE-AQKQVKSLQSLLKD-TQIQLDDAVRA 907
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---- 1070
N LK+ + N + ++V E +L E +Q + Q
Sbjct: 908 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 967
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ K+ + +L L E ++ ++E + + + I T+ +++ ++ D + +++
Sbjct: 968 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI--TDAAMMAEELKKEQDTSAHLER 1025
Query: 1131 XXXXXXXXXXXL--KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L ++ E E+ + ++Q KL ++E ++ + N E
Sbjct: 1026 MKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELENELEAEQKRNAESVKG 1083
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
++ +I +L + E+ L V +L+ + A ++ E E +L++
Sbjct: 1084 MRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSK--- 1139
Query: 1249 DFQKTEHEL 1257
F+K +HEL
Sbjct: 1140 -FRKVQHEL 1147
Score = 90.2 bits (214), Expect = 5e-17
Identities = 192/1117 (17%), Positives = 443/1117 (39%), Gaps = 85/1117 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEAKNKATTXXXXXXX 201
+ T L +++ + L+ KM + DLQ ++ E+D + +A+ +
Sbjct: 99 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 158
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEE-----A 256
+ + +M A + + +DE L +DI+ ++ ++ +E+
Sbjct: 159 LEAKVKEM--NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 216
Query: 257 NKLLEAARFEISLEH--SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
NK+ L+ +KL +E ++ + + + K ++E++
Sbjct: 217 NKVKNLTEEMAGLDEIIAKLTKE-KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 275
Query: 315 SLEIANMTELTKKIEL-LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
++ E KK+ + LE ++ K + + + + + + KK ++
Sbjct: 276 D-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 334
Query: 374 SGR-----NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+ R S+++ +L + + + + + AK+E + L+++L + +
Sbjct: 335 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 394
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
E ++ A+ Q + ++ +E +L H T + K E
Sbjct: 395 EEAGGATSVQIEMNKKRE---AEFQ-KMRRDLEEATLQHEAT----AAALRKKHADSVAE 446
Query: 489 LNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI-DNF 547
L ++I N++ + +KL+ + + D++ + + +IK K+N + + ++ + ++
Sbjct: 447 LGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 504
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
SK ++ + + LT + L + EL + + + G++ + +++ +++
Sbjct: 505 SKAEETQRSVNDLTSQQAKLQTENGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKR 561
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E +KA + L + +L+++Y+E + A++ ++ S + SE+ + +
Sbjct: 562 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYE 620
Query: 668 IDA------LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI------- 714
DA L +KK+LA ++ + E + LE K + N++++ +
Sbjct: 621 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 680
Query: 715 ---------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
Q N D K E+ L E +S F + +E ++E
Sbjct: 681 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 740
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDELV 824
+ E + I L E + + LE+ QL + E Q A E E E
Sbjct: 741 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 800
Query: 825 NRLAVLMDHDRV---VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L ++ +++ +E++L E + E E K+N + + ++ + ++ V+
Sbjct: 801 KILRAQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 859
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
K DL E E QL S+ R+ E Q + + ++D +I Q++ A+R
Sbjct: 860 KKMEGDLNEME-----IQL----SHANRMAAEAQKQVKSLQSLLKDTQI----QLDDAVR 906
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
L E L+A+L+E + +E + +L + L + VQ +Q+
Sbjct: 907 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLHSQN- 964
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
IN+ K++A L Q E+ Q+ NA+ ++D + +A+ K ++
Sbjct: 965 ---TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTS 1020
Query: 1062 EEMQRVSK---QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
++R+ K Q + QH +E QI ++ Q+++L+ E + + S
Sbjct: 1021 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES 1080
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKI 1175
+ + L++Q+ + +Q + + Q+ + + +K
Sbjct: 1081 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1140
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+++ E + + Q+N+L++K + T+ N
Sbjct: 1141 RKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1177
Score = 81.4 bits (192), Expect = 2e-14
Identities = 189/917 (20%), Positives = 384/917 (41%), Gaps = 81/917 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+KD L+ L +++ + LQ+K+ E IE +
Sbjct: 316 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 375
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 376 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 431
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ +H+ EL + K + ++ T E+ AN+
Sbjct: 432 TAAALRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEFKLELDDVTSNMEQIIKAKANLE 490
Query: 323 ELTKKIE--LLEHLNC--QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
++ + +E + EH + + +++ +L ++ A + TE+ +S + LIS+
Sbjct: 491 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQTENGELSRQLDEKEALISQ------ 544
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXX 436
++ K ++Q + Q ++ KN +A +QS DL+ ++Y E++T
Sbjct: 545 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQY---EEETEAK 598
Query: 437 XXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K ++ +AQ + +++ TE++ E K Q QE + ++
Sbjct: 599 AELQRVLSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEEAVEA 650
Query: 496 VNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSK 549
VN K +EK K + +I L +++ +N K ++ K+ + QK ++ S+
Sbjct: 651 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 710
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+ S KE L+ EL L EE +L+ + + + SD+ +++
Sbjct: 711 LESSQKEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 767
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
K LE++K +L L + + E K+ +QL+ +Q+ +EI+ L E+ +
Sbjct: 768 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR-AQLEFNQIKAEIER-KLAEKDE 825
Query: 670 ALSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+ +K+ V+++L+ LD E N+ + K++ + E +M
Sbjct: 826 EMEQAKRNHLRVVDSLQTSLDAE------TRSRNEALRVKKKMEGDLNEMEIQLSHANRM 879
Query: 728 SAEKISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+AE ++ + QS ++ TQ +D ++ D ENI + LEE A
Sbjct: 880 AAEAQKQVKSL-----QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 934
Query: 787 VMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
V+E S + +L + Q +S+ T ++ A L VE+ + E +
Sbjct: 935 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 994
Query: 847 ENKELQK---KNQILLEE---NQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQT 898
++ +K ++ EE Q+ L M+++ + + +R D AE + K +
Sbjct: 995 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1054
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---- 954
QL+ LE+ ++ + +E L ++K+ E ++ + E I++ E+ KN+
Sbjct: 1055 QLQKLEARVRELENE---LEAEQKRNAE--SVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1109
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ V +L+ +++ YK E EE NL K VQ + ++ + + +++NKL
Sbjct: 1110 DLVDKLQLKVKAYKRQAE----EAEEQANTNLSKFRK-VQHELDEAEERADIAESQVNKL 1164
Query: 1015 NALLKQKDEEIIALNQK 1031
A K +D LN++
Sbjct: 1165 RA--KSRDIGTKGLNEE 1179
>M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protein-170
alpha-2 protein.
Length = 1392
Score = 111 bits (267), Expect = 2e-23
Identities = 153/720 (21%), Positives = 319/720 (44%), Gaps = 54/720 (7%)
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK 506
T I +++L++Q +E E+ ++ +L + + + K+ +++ + KL
Sbjct: 615 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE--KENSLEAIRSKLD 672
Query: 507 SAEEQ-ITQLNDEIDAANKNMIKVKSNHKLKLK--QMQKTIDNF-SKVSDSNKEIVRLT- 561
AE+Q + ++ D ++ + IKVK L+ K + K IDNF S++ + ++++ L
Sbjct: 673 KAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 732
Query: 562 ---------EELHHLSQKVAELEEEKGNLQLHL-VDYDSGRMIESDVYKKMIEMENLAET 611
E+ L Q++ E++ +L++ + I ++ + +++ NL E
Sbjct: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN 792
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
+S + K L +EL IL++K+ E ++ + + + V K EEQ + L
Sbjct: 793 ----LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN---KLHQKEEQFNML 845
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
S+ ++L ENL D E + + E KL+N I E M ++ +
Sbjct: 846 SSDLEKLR---ENLA-DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 901
Query: 732 ISELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
EL K E+ +++ T+ +A ++ + +++E S+ ++ + EE +E
Sbjct: 902 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELER 960
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQ-----EDELVNRLAVLMD-HDRV--VEKQLL 842
+ LE+K + + QE + Y T + E+ L N L+D D++ ++
Sbjct: 961 KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
+ E +EL+K+ + + Q + ++ M+Q E + + + K Q +L
Sbjct: 1021 GLLQELEELRKQAE-KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1079
Query: 903 L-ESNLKRIT--HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L E+NLK + ++ + L+ + +++E+ E T ++A + + L+ E+N++ +
Sbjct: 1080 LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1139
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
L E ++ + L LN LE+ K K + + I+ +ALL
Sbjct: 1140 LGRSRDEVTSH-QKLEEERSVLNNQLLEM-KKRESKFIKDADEEKASLQKSISITSALLT 1197
Query: 1020 QKDEEIIALNQKI------NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
+KD E+ L ++ N + S S+V ES + K++N+E +++ +QL
Sbjct: 1198 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSS 1257
Query: 1074 SKQHNE-ELQILVREQDDQIKELKETKLTFE---MNIPKTEGMIISSTIEPMSDDANNVD 1129
S + + + R Q+ QI L + + ++ M+ + + DD NN D
Sbjct: 1258 SSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1317
Score = 103 bits (248), Expect = 4e-21
Identities = 162/904 (17%), Positives = 368/904 (40%), Gaps = 77/904 (8%)
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE----EQSKIQTQFGIDAKIQE 759
++ + + Q +I++ + D LE+ K + + +I E Q ++AK+ +
Sbjct: 354 QEALKEKQQHIEQLLAERD-LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
+E + E + ++ LEE +ED ++ +E ++ G S
Sbjct: 413 LRTMVEAADREKVELLNQ---LEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMEL 469
Query: 820 EDELVNRLAVLMDHDRVVEKQL--------LEIEHENKELQKKNQILLEENQNLQISLSD 871
E +L R+ + + R +E L + E LQ+K ++ ++Q ++
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR---EITS 526
Query: 872 MQQHYNALVEKANRTDLAESEST-KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
+++H+ A E + A +T K + L+S L+ E+ +I K ++E
Sbjct: 527 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 586
Query: 931 EFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+E + K L + + E TQ+E +Y++ IENL + +
Sbjct: 587 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA--- 643
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALL-KQKDEEIIALNQKINNAQVSYMSM--VSDY 1046
K ++ + + ++ N + + + L K +D+ ++ + +N Q + + + +
Sbjct: 644 -KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 702
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLD-------SKQHNEELQILVREQDDQIKELKETK 1099
++K + T ++N +++ ++LLD S + E++ L ++ + K++K
Sbjct: 703 QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH-- 760
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQ 1158
L E N ++ I+ ++ N+ L ++E + ++E+ +
Sbjct: 761 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL--EKELQILKEKFAEAS 818
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
E++ + +QE K+ Q E L+ +E + +++K + + + L+
Sbjct: 819 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
Query: 1219 ELRSSISSAVDQRGFEIAELWKQH--LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
+L + I+ + G ++L K + L +E D + EL+++L+ L S++
Sbjct: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE----ELQLKLTKANENASFLQKSIE 934
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
T V EQ S Q + EE + L+ K +D+ ++E ++ ++ K +
Sbjct: 935 DMT-------VKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 1337 XXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+L Q E + EEN+ L +
Sbjct: 986 ATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQT 1041
Query: 1397 DAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE 1456
+A +++ Q+ + +E + T + +E + +++ + K +E+L KE
Sbjct: 1042 AEDA--MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL---KNVEELNKSKE 1096
Query: 1457 SELAILRLKMHENANHYETMQKES--EIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
L + KM E ET+++ + + +++ ++E NVK+ E + ++ ++ LEE
Sbjct: 1097 L-LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1155
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
E + N ++ +E + + DE + +QK +S S +D +L+
Sbjct: 1156 ERSVLNNQLLEMKKRESKFIKDADE----------EKASLQKSISITSALLTEKDAELEK 1205
Query: 1575 TMNK 1578
N+
Sbjct: 1206 LRNE 1209
Score = 102 bits (244), Expect = 1e-20
Identities = 190/992 (19%), Positives = 422/992 (42%), Gaps = 80/992 (8%)
Query: 358 AVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
A +S S K SP S S ++ + S S+ S L +T + + +I+ + ++L
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVS--SRPSRTGLLTETSSRYAR-KISGTTALQEAL 357
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ E +++E+D + +L L H + ++ + + +
Sbjct: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ--HVLELEAKMDQLRT 415
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKL 537
+ + ++ K EL +++++ K + + EE IT+ + E+ ++ ++ L L
Sbjct: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLAL 475
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+ + + + +SNK + L L Q+++ L+E+ L + D R I S
Sbjct: 476 RVQE--VAELRRRLESNKPAGDVDMSLS-LLQEISSLQEK-----LEVTRTDHQREITS- 526
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI-----SQLQ- 651
K+ ET K I L + L +E L+ K + + +D+ S+L+
Sbjct: 527 -LKEHFGARE--ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 652 ---SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK----- 703
S Q E V + + +A EL IE ++LD + +++ ++ +
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
Query: 704 ---EDIMNKLQNYIQENMD----LTDKLEKMSAEKISELLAKIN--HEEQSKIQTQFGID 754
E + KL I+E + + KL+K + + E+ +N E + K++ +
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 755 AKIQERDLYIENIESELSKYKSRICRLE-------ESIAVMEDRRYSLERKADQLGSYLQ 807
AK E+ I+N S+L + ++ L+ E + M+ R LE Q+
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE---ENQN 864
EK S+ + EL R L + +++ L E+ + L+K+ QIL E E
Sbjct: 764 EKNAESSKASSITRELQGRELKLTN----LQENLSEVSQVKETLEKELQILKEKFAEASE 819
Query: 865 LQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
+S+ MQ+ N L +K + ++ S+ K + L D+E+ + + LI K+K
Sbjct: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEK 879
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
D+ +++ + K +N++ V +L+ +L + N L ++E++
Sbjct: 880 LENDIAEIMKMSGDNSSQLTK-MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT- 937
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK-INNAQVSYMSM 1042
+ E + K+ + E+ ++++ K + +E+ A ++ + + + +
Sbjct: 938 VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI 997
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD-QIKE---LKET 1098
+ + + L KL+ EE + ++L + ++ E+ + +D QI E ++T
Sbjct: 998 LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKT 1057
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
+ + K + + ++ + ++ N + ++ Q+ EEF +E L+
Sbjct: 1058 ETLASLEDTKQTNAKLQNELDTLKEN-NLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1116
Query: 1159 EQSAKLNTE---LQECYTKII-QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
+ +A+ + + LQE K+ +L E+T H + +E+ + L ++L ++ +
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFI 1175
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDS 1274
E ++S+ ++ + L +++A+ +K +E+ V L + + L
Sbjct: 1176 KDADEEKASLQKSI--------SITSALLTEKDAELEKLRNEVTV-LRGENASAKSLHSV 1226
Query: 1275 VQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
VQ+ E++K+ +V +L+ +L++ + L
Sbjct: 1227 VQTL---ESDKVKLELKVKNLELQLKENKRQL 1255
Score = 72.5 bits (170), Expect = 1e-11
Identities = 120/597 (20%), Positives = 248/597 (41%), Gaps = 61/597 (10%)
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+Q+ + + EQ + E + A + + + + Q++ A+ + V + E+K+ Q
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
T +E + E + QL + K+ E+LQ V E+ +L+ ++ + I + E
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE-K 471
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
++ ++ +++ ++ V +QE S LQE+ T+ Q
Sbjct: 472 DLALRVQEVAELRRRLESNKPAG-------DVDMSLSLLQEISSLQEKLEVTRTDHQR-- 522
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG 1232
++ +L + +Q++I L + E+L+ EN++ L+S + A ++
Sbjct: 523 ----EITSLKEHFGAREETHQKEIKALYTATEKLSKENES-------LKSKLEHA-NKEN 570
Query: 1233 FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
++ LWK L A Q+ EL+V S + + + + TQ E ++ ++
Sbjct: 571 SDVIALWKSKLETAIASHQQAMEELKVSFS--KGLGTETAEFAELKTQIEKMRLDYQHEI 628
Query: 1293 TSLQNKLQDKE-----EHLRNLQEKYADVI----NQIEILRSEI---EDEKVAFXXXXXX 1340
+LQN+ QD E + + L+ K VI N +E +RS++ ED+ +
Sbjct: 629 ENLQNQ-QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 687
Query: 1341 XXXXXXXXXXDLRTE----NQSYKQMQE-QSILNINEENA----QLKKSSXXXXXXXXXX 1391
+L N+ K + S L EE L+K+S
Sbjct: 688 KLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 747
Query: 1392 XXRVNDAEAKV--LELTHQLE-LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
++ AE ++ LE+ E K S I ++ + LT + V Q EK +
Sbjct: 748 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 807
Query: 1449 EDL--TYEKESELAI-LRLKMHENANHYETMQKE-----SEIERVK-LIEELNVKITESV 1499
+ L + + SE A+ ++ M E N +++ S++E+++ + ++ K E
Sbjct: 808 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 867
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+Q+ + + LE ++A+ +M + ++ +NDE+ + V K+ K
Sbjct: 868 EREEQLIKAKEKLENDIAEIMKMS---GDNSSQLTKMNDELRLKERDVEELQLKLTK 921
Score = 59.7 bits (138), Expect = 9e-08
Identities = 133/690 (19%), Positives = 279/690 (40%), Gaps = 75/690 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMK--------IMETTILDLQE-------------KINEKDQI 185
L IKEK+N+L ++ K+ ME T+ LQE K NE+ ++
Sbjct: 653 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 712
Query: 186 IE---AKNKATTXXXXXXXXXXXXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQR- 238
I+ ++ KAT + K QQ+ ++ +E E E +
Sbjct: 713 IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 772
Query: 239 --LLKDIESKDVRISSLE----EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXX 292
+ ++++ +++++++L+ E +++ E E+ + K A+ E+
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 832
Query: 293 XXLAKQ---------SIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK 343
L ++ +E E ++E K + +L K E LE+ +I + +
Sbjct: 833 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 892
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+ ++L M E + + + L K+ N + KS +Q K +
Sbjct: 893 DNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXXXXXXXGKDTLIAQLQ---LEHQQH 459
+ E +LE + L K + E K + ++ LQ L+ +
Sbjct: 952 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1011
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLK--QELND--EIKDVNVKDLIEKLKSAE---EQI 512
++G + G +++ E+ K E+ K Q D +I + K+ E L S E +
Sbjct: 1012 LKGAREENSGL-LQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1070
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
+L +E+D +N +K+ +L + T++N K+ + KEI L + SQ+++
Sbjct: 1071 AKLQNELDTLKEN--NLKNVEELNKSKELLTVEN-QKMEEFRKEIETLKQAAAQKSQQLS 1127
Query: 573 ELEEEKGNLQLHLVDYDSGR-MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
L+EE L L GR E ++K+ E ++ +L + ES+ E
Sbjct: 1128 ALQEENVKLAEEL-----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
Query: 632 ILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
QK + L + +++ +E+ + E +AS K L V++ L+ DK +
Sbjct: 1183 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------NASAKSLHSVVQTLESDKVK 1236
Query: 692 LYGTIKDLENDKEDIMNKLQN---YIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KI 747
L +K+LE ++ +L + D ++ ++ + ++ ++ + + Q K+
Sbjct: 1237 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1296
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSR 777
+ + +A + + N +S+ + +S+
Sbjct: 1297 KVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1326
Score = 52.4 bits (120), Expect = 1e-05
Identities = 124/648 (19%), Positives = 249/648 (38%), Gaps = 63/648 (9%)
Query: 4 TKNIDH-PSEMELSEETTARLPSSEVSSVAGXXXXXXXXXXXXXXXERQIKFERAQKCLE 62
TK ID+ S+++ +EE L + +S G E+QIK +K E
Sbjct: 710 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLEIEKNAE 768
Query: 63 NAALVSKRIKEHRKATAELLGRPF-VPGISESLANTLKQKEILMEKIKQYKELSKRSSTT 121
++ S T EL GR + + E+L+ + KE L ++++ KE +S
Sbjct: 769 SSKASS--------ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 820
Query: 122 IVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINE 181
V + N + +K+ ++L ++ + + D++ K E
Sbjct: 821 AVSVQRS---------------MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 865
Query: 182 KD----QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQ 237
KD Q+I+AK K D Q+TKM + E + ++ +
Sbjct: 866 KDEREEQLIKAKEKLENDIAEIMKMSG--------DNSSQLTKMNDELRLKERDVEELQL 917
Query: 238 RLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAK 297
+L K E+ S+E+ E ++ E + +H + +ELE+ +
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD-----------LE 966
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESK 357
+ +E S + E+ K E A TK E+L++L ++T + E+KL E+
Sbjct: 967 KKMETSHNQCQEL--KARYERATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENS 1020
Query: 358 AVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ ++ + TA Q++ E + K AKL+ + +L
Sbjct: 1021 GLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Query: 418 NK-DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN 476
+ +L + E + K+ + + Q Q+ + +L N +
Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAE 1138
Query: 477 EIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
E+ + ++++ Q+L +E +N L+E K + I ++E + K++ +
Sbjct: 1139 ELGRSRDEVTSHQKLEEERSVLN-NQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1197
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K +++K + + + N L + L +LE + NL+L L ++ R +
Sbjct: 1198 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL--KENKRQL 1255
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
S + + + I L S DL ++ L+ K + + +
Sbjct: 1256 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
Score = 49.2 bits (112), Expect = 1e-04
Identities = 106/587 (18%), Positives = 240/587 (40%), Gaps = 44/587 (7%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+ HL + + S + +++ E + +LQE ++E Q+ E K
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 817
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
++ + K+ + + ++L +++ + + +E + L A
Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNM-LSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 264 RFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+ ++ + +++ ++ L ++ +E + T+ E S ++ +
Sbjct: 877 KEKLENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 935
Query: 324 LTKKIELLEHLNC-QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+T K E + + + KELE KL+ + E K +S N ++
Sbjct: 936 MTVKAEQSQQEAAKKHEEEKKELERKLSDL--EKKMETS--------------HNQCQEL 979
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
K+ + + +SET + ++I +N + K + + K ++ + ++
Sbjct: 980 KARYERATSET--KTKHEEILQN-LQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKA 1036
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
T +Q+ Q E + +T+ N AK+Q +L D +K+ N+K+ +
Sbjct: 1037 KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN--AKLQNEL-----DTLKENNLKN-V 1088
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
E+L ++E +T N +++ K + +K K +Q+ + K+++ E+ R +
Sbjct: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE---ELGRSRD 1145
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
E+ QK+ E N L + +S + ++D K ++ + L E +
Sbjct: 1146 EVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1204
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
K L E+ +L+ + + + + L+SD+V E+K +LE Q L +K++L+
Sbjct: 1205 K--LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQ---LKENKRQLSSSS 1259
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ-ENMDLTDKLEKMS 728
N ++ + + + D +N + +Q +N DL K+E MS
Sbjct: 1260 GNTDTQADE----DERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1302
>BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containing
linker protein 1 protein.
Length = 1392
Score = 110 bits (264), Expect = 5e-23
Identities = 157/717 (21%), Positives = 314/717 (43%), Gaps = 48/717 (6%)
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV--NVKDLIEK 504
T I +++L++Q +E + N+E AK E L+ +L IK+ +++ + K
Sbjct: 615 TQIEKMRLDYQHEIEN---LQNQQNSERAAH-AKEMEALRAKLMKVIKEKENSLEAIRSK 670
Query: 505 LKSAEEQ-ITQLNDEIDAANKNMIKVKSNHKLKLK--QMQKTIDNFSKVSDSNKEIVRLT 561
L AE+Q + ++ D ++ + IKVK L+ K + K IDNF+ + +E +
Sbjct: 671 LDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQPKATEEKLLDL 730
Query: 562 EELHHLSQK-VAELEEEKGNLQL------HLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ L S + +E+++ + L+ HL + ++ + ++ L T L+
Sbjct: 731 DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ 790
Query: 615 A-ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA 673
+S + K L +EL IL++K+ E ++ + + + V K EEQ + LS+
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN---KLHQKEEQFNMLSS 847
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
++L ENL D E + + E KL+N I E M ++ +
Sbjct: 848 DLEKLR---ENLA-DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 903
Query: 734 ELLAKINHEEQSKIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
EL K E+ +++ T+ +A ++ + +++E S+ ++ + EE +E +
Sbjct: 904 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKL 962
Query: 793 YSLERKADQLGSYLQEKQKAYSEYTIQ-----EDELVNRLAVLMDHDRVVEKQLLEIEHE 847
LE+K + + QE + Y T + E+ L N L+D + ++ E
Sbjct: 963 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
Query: 848 NKELQ--KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-E 904
+EL+ +K + Q + ++ M+Q E + + + K Q +L L E
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 905 SNLKRIT--HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
+NLK + ++ + L+ + +++E+ E T ++A + + L+ E+N++ +L
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
E ++ + L LN LE+ K K + + I+ +ALL +KD
Sbjct: 1143 SRDEVTSH-QKLEEERSVLNNQLLEM-KKRESKFIKDADEEKASLQKSISITSALLTEKD 1200
Query: 1023 EEIIALNQKI------NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
E+ L ++ N + S S+V ES + K++N+E +++ +QL S
Sbjct: 1201 AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1260
Query: 1077 HNE-ELQILVREQDDQIKELKETKLTFE---MNIPKTEGMIISSTIEPMSDDANNVD 1129
+ + + R Q+ QI L + + ++ M+ + + DD NN D
Sbjct: 1261 NTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1317
Score = 102 bits (245), Expect = 9e-21
Identities = 165/906 (18%), Positives = 369/906 (40%), Gaps = 81/906 (8%)
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE----EQSKIQTQFGIDAKIQE 759
++ + + Q +I++ + D LE+ K + + +I E Q ++AK+ +
Sbjct: 354 QEALKEKQQHIEQLLAERD-LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
+E + E + ++ LEE +ED ++ +E ++ G S
Sbjct: 413 LRTMVEAADREKVELLNQ---LEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMEL 469
Query: 820 EDELVNRLAVLMDHDRVVEKQL--------LEIEHENKELQKKNQILLEENQNLQISLSD 871
E +L R+ + + R +E L + E LQ+K ++ ++Q ++
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR---EITS 526
Query: 872 MQQHYNALVEKANRTDLAESEST-KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
+++H+ A E + A +T K + L+S L+ E+ +I K ++E
Sbjct: 527 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 586
Query: 931 EFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+E + K L + + E TQ+E +Y++ IENL N+ N E
Sbjct: 587 SHQQAMEELKVSFSKGLGAETAEFAELKTQIEKMRLDYQHEIENLQ------NQQNSERA 640
Query: 990 D--KHVQKQQTQSPDYTEQYINEINKLNALL-KQKDEEIIALNQKINNAQVSYMSM--VS 1044
K ++ + + ++ N + + + L K +D+ ++ + +N Q + + + +
Sbjct: 641 AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE 700
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLD-------SKQHNEELQILVREQDDQIKELKE 1097
++K + T ++N + + ++LLD S + E++ L ++ + K++K
Sbjct: 701 VLQAKCNEQTKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH 760
Query: 1098 TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SV 1156
L E N ++ I+ ++ N+ L ++E + ++E+ +
Sbjct: 761 --LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL--EKELQILKEKFAE 816
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
E++ + +QE K+ Q E L+ +E + +++K + + + L+
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQH--LAQREADFQKTEHELRVQLSAFESKYEQLLDS 1274
+L + I+ + G ++L K + L +E D + EL+++L+ L S
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE----ELQLKLTKANENASFLQKS 932
Query: 1275 VQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF 1334
++ T V EQ S Q + EE + L+ K +D+ ++E ++ ++ K +
Sbjct: 933 IEDMT-------VKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARY 983
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
+L Q E + EEN+ L +
Sbjct: 984 ERATSETKTKHEEILQNL----QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1039
Query: 1395 VNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
+A +++ Q+ + +E + T + +E + +++ + K +E+L
Sbjct: 1040 QTAEDA--MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL---KNVEELNKS 1094
Query: 1455 KESELAILRLKMHENANHYETMQKES--EIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
KE L + KM E ET+++ + + +++ ++E NVK+ E + ++ ++ L
Sbjct: 1095 KEL-LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1153
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
EEE + N ++ +E + + DE + +QK +S S +D +L
Sbjct: 1154 EEERSVLNNQLLEMKKRESKFIKDADE----------EKASLQKSISITSALLTEKDAEL 1203
Query: 1573 DNTMNK 1578
+ N+
Sbjct: 1204 EKLRNE 1209
Score = 101 bits (242), Expect = 2e-20
Identities = 190/992 (19%), Positives = 422/992 (42%), Gaps = 80/992 (8%)
Query: 358 AVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
A +S S K SP S S ++ + S S+ S L +T + + +I+ + ++L
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVAPSVS--SRPSRTGLLTETSSRYAR-KISGTTALQEAL 357
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ E +++E+D + +L L H + ++ + + +
Sbjct: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ--HVLELEAKMDQLRT 415
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKL 537
+ + ++ K EL +++++ K + + EE IT+ + E+ ++ ++ L L
Sbjct: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLAL 475
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
+ + + + +SNK + L L Q+++ L+E+ L + D R I S
Sbjct: 476 RVQE--VAELRRRLESNKPAGDVDMSLS-LLQEISSLQEK-----LEVTRTDHQREITS- 526
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI-----SQLQ- 651
K+ ET K I L + L +E L+ K + + +D+ S+L+
Sbjct: 527 -LKEHFGARE--ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 652 ---SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK----- 703
S Q E V + + A +A EL IE ++LD + +++ +N +
Sbjct: 584 AIASHQQAMEELKVSFSKGLGAETAEFAELKTQIEKMRLDYQHEIENLQNQQNSERAAHA 643
Query: 704 ---EDIMNKLQNYIQENMD----LTDKLEKMSAEKISELLAKIN--HEEQSKIQTQFGID 754
E + KL I+E + + KL+K + + E+ +N E + K++ +
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 755 AKIQERDLYIENIESELSKYKSRICRLE-------ESIAVMEDRRYSLERKADQLGSYLQ 807
AK E+ I+N S+ + ++ L+ E + M+ R LE Q+
Sbjct: 704 AKCNEQTKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE---ENQN 864
EK S+ + EL R L + +++ L E+ + L+K+ QIL E E
Sbjct: 764 EKNAESSKASSITRELQGRELKLTN----LQENLSEVSQVKETLEKELQILKEKFAEASE 819
Query: 865 LQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
+S+ MQ+ N L +K + ++ S+ K + L D+E+ + + LI K+K
Sbjct: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEK 879
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
D+ +++ + K +N++ V +L+ +L + N L ++E++
Sbjct: 880 LENDIAEIMKMSGDNSSQLTK-MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT- 937
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK-INNAQVSYMSM 1042
+ E + K+ + E+ ++++ K + +E+ A ++ + + + +
Sbjct: 938 VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI 997
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD-QIKE---LKET 1098
+ + + L KL+ EE + ++L + ++ ++ + +D QI E ++T
Sbjct: 998 LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
+ + K + + ++ + ++ N + ++ Q+ EEF +E L+
Sbjct: 1058 ETLASLEDTKQTNAKLQNELDTLKEN-NLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1116
Query: 1159 EQSAKLNTE---LQECYTKII-QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
+ +A+ + + LQE K+ +L E+T H + +E+ + L ++L ++ +
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFI 1175
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDS 1274
E ++S+ ++ + L +++A+ +K +E+ V L + + L
Sbjct: 1176 KDADEEKASLQKSI--------SITSALLTEKDAELEKLRNEVTV-LRGENASAKSLHSV 1226
Query: 1275 VQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
VQ+ E++K+ +V +L+ +L++ + L
Sbjct: 1227 VQTL---ESDKVKLELKVKNLELQLKENKRQL 1255
Score = 70.5 bits (165), Expect = 5e-11
Identities = 107/585 (18%), Positives = 251/585 (42%), Gaps = 37/585 (6%)
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+Q+ + + EQ + E + A + + + + Q++ A+ + V + E+K+ Q
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
T +E + E + QL + K+ E+LQ V E+ +L+ ++ + I + E
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE-K 471
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECY 1172
++ ++ +++ ++ +QE ++ V + + T L+E +
Sbjct: 472 DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 531
Query: 1173 --TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST-VAELRSSISSAVD 1229
+ + + T + +++E LKSKLE N EN ++++ ++L ++I+S
Sbjct: 532 GAREETHQKEIKALYTATEKLSKEN-ESLKSKLEHANKENSDVIALWKSKLETAIASH-Q 589
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM 1289
Q E+ + + L A+F EL+ Q+ Y+ ++++Q+ Q+ + +
Sbjct: 590 QAMEELKVSFSKGLGAETAEFA----ELKTQIEKMRLDYQHEIENLQN--QQNSERAAHA 643
Query: 1290 EQVTSLQNKL----QDKEEHLRNLQEKYADVINQ--IEILRSEIEDEKVAFXXXXXXXXX 1343
+++ +L+ KL ++KE L ++ K +Q +E+ + + ++
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 1344 XXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV- 1402
+ S + E+ +L+++ L+K+S ++ AE ++
Sbjct: 704 AKCNEQTKVIDNFTSQPKATEEKLLDLD----ALRKASSEGKSEMKKLRQQLEAAEKQIK 759
Query: 1403 -LELTHQLE-LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL--TYEKESE 1458
LE+ E K S I ++ + LT + V Q EK ++ L + + SE
Sbjct: 760 HLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE 819
Query: 1459 LAI-LRLKMHENANHYETMQKE-----SEIERVK-LIEELNVKITESVSLNKQVAELNKA 1511
A+ ++ M E N +++ S++E+++ + ++ K E +Q+ + +
Sbjct: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEK 879
Query: 1512 LEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
LE ++A+ +M + ++ +NDE+ + V K+ K
Sbjct: 880 LENDIAEIMKMS---GDNSSQLTKMNDELRLKERDVEELQLKLTK 921
Score = 58.8 bits (136), Expect = 1e-07
Identities = 132/690 (19%), Positives = 279/690 (40%), Gaps = 75/690 (10%)
Query: 147 LSNTIKEKDNALSVLQVKMK--------IMETTILDLQE-------------KINEKDQI 185
L IKEK+N+L ++ K+ ME T+ LQE K NE+ ++
Sbjct: 653 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 712
Query: 186 IE---AKNKATTXXXXXXXXXXXXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQR- 238
I+ ++ KAT + K QQ+ ++ +E E E +
Sbjct: 713 IDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 772
Query: 239 --LLKDIESKDVRISSLE----EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXX 292
+ ++++ +++++++L+ E +++ E E+ + K A+ E+
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 832
Query: 293 XXLAKQ---------SIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNK 343
L ++ +E E ++E K + +L K E LE+ +I + +
Sbjct: 833 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 892
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+ ++L M E + + + L K+ N + KS +Q K +
Sbjct: 893 DNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXXXXXXXGKDTLIAQLQ---LEHQQH 459
+ E +LE + L K + E K + ++ LQ L+ +
Sbjct: 952 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1011
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLK--QELND--EIKDVNVKDLIEKLKSAE---EQI 512
++G + G +++ E+ K ++ K Q D +I + K+ E L S E +
Sbjct: 1012 LKGAREENSGL-LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN 1070
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
+L +E+D +N +K+ +L + T++N K+ + KEI L + SQ+++
Sbjct: 1071 AKLQNELDTLKEN--NLKNVEELNKSKELLTVEN-QKMEEFRKEIETLKQAAAQKSQQLS 1127
Query: 573 ELEEEKGNLQLHLVDYDSGR-MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
L+EE L L GR E ++K+ E ++ +L + ES+ E
Sbjct: 1128 ALQEENVKLAEEL-----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
Query: 632 ILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
QK + L + +++ +E+ + E +AS K L V++ L+ DK +
Sbjct: 1183 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGE------NASAKSLHSVVQTLESDKVK 1236
Query: 692 LYGTIKDLENDKEDIMNKLQN---YIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KI 747
L +K+LE ++ +L + D ++ ++ + ++ ++ + + Q K+
Sbjct: 1237 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1296
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSR 777
+ + +A + + N +S+ + +S+
Sbjct: 1297 KVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1326
Score = 49.2 bits (112), Expect = 1e-04
Identities = 105/582 (18%), Positives = 225/582 (38%), Gaps = 32/582 (5%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXX 203
+ HL + + S + +++ E + +LQE ++E Q+ E K
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 817
Query: 204 XXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
++ + K+ + + ++L +++ + + +E + L A
Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNM-LSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 264 RFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+ ++ + +++ ++ L ++ +E + T+ E S ++ +
Sbjct: 877 KEKLENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 935
Query: 324 LTKKIELLEHLNC-QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+T K E + + + KELE KL+ + + + + ++ R + T +K
Sbjct: 936 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS-ETKTKH 994
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ L L+ + K + E + L ++ L K DK +
Sbjct: 995 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-ADKAKAAQTAEDAMQIMEQMT 1053
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHV--GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD 500
K +A L+ Q + + + + N ++V E+ K +E L E N ++++ +
Sbjct: 1054 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE-NQKMEEFRKE- 1111
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
IE LK A Q +Q + N + + + ++ QK + S +++ +L
Sbjct: 1112 -IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN------QL 1164
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK-------MIEMENLAETRL 613
E S+ + + +EEK +LQ + S + E D + ++ EN + L
Sbjct: 1165 LEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL 1223
Query: 614 -KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
+ LES K L ++ L+ + E + +L+ S Q + ++ E QID L+
Sbjct: 1224 HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA--QESQIDFLN 1281
Query: 673 ASKKELALVIENLKLDKEQ-----LYGTIKDLENDKEDIMNK 709
+ +L ++LK+ E L G DL N D K
Sbjct: 1282 SVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEK 1323
>AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.19 protein.
Length = 820
Score = 110 bits (264), Expect = 5e-23
Identities = 179/870 (20%), Positives = 373/870 (42%), Gaps = 82/870 (9%)
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
+ K+QL + L ++ +NK ++ + D+ ++ E + A+ I + ++I + +
Sbjct: 4 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ-IQQFHSQIAAQTSAS 62
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+ + + I E+D I+ E L+ + R+ EE + +++ + L+ + +L +
Sbjct: 63 VLAE-ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 121
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL-EIEHENKE---LQKKNQILLEEN 862
E+ A E +++ + V D R++E+QL EI ++ +E L +N+ L E
Sbjct: 122 NEQAAAAHEL----EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV 177
Query: 863 QNLQISLSD------MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
Q LQ +S+ ++Q + EK + E Q+ E L I E+ +
Sbjct: 178 QKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSS 237
Query: 917 LIVQKKKEIEDLEIEFNTQIE--SAIRD-KKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
L KE++DL+ + N Q+ S + + KKV++EK K LEA+L + N +
Sbjct: 238 LT----KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKT 293
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
+ +E+ + E+ + ++K Q S +++ +L LLK K+E++ +
Sbjct: 294 VQDLKQEIKALKEEIGNVQLEKAQQLS------ITSKVQELQNLLKGKEEQMNTMK---- 343
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+++ + E LA L++++EE + + + + QHN + Q +
Sbjct: 344 -------AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN----LKEASSASQFE 392
Query: 1094 ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
EL+ E + + E M+ + D ++ K Q E+ +++
Sbjct: 393 ELEIVLKEKENELKRLEAML-----KERESDLSSKTQLLQDVQDENKLFKSQIEQ--LKQ 445
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNL 1213
++ Q S + EL K+I E++G +++ LK +E +N++L
Sbjct: 446 QNYQQASSFPPHEEL----LKVISER--EKEISGL----WNELDSLKDAVEHQRKKNNDL 495
Query: 1214 LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA---DFQKTEHELRVQLSAFES-KYE 1269
E +++S ++ + K+ Q EA + ++ +L ++S + Y
Sbjct: 496 REKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYG 555
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ---EKYADVINQIE----I 1322
+ L + +E E+V L++KL++ +E LQ EKY V+ + E
Sbjct: 556 EWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK 615
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS--ILNINEENAQLKKS 1380
L+ +E E+ + + Q ++++ ++ I N+ E L+
Sbjct: 616 LQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEME 675
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
V + + + EL +L+ SE ++ E + Q N+ +R +
Sbjct: 676 LEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTE 735
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS 1500
E +K DL ++ + L +++ K+ + A T+ + S++ E + K T SVS
Sbjct: 736 QNERQKVAGDL-HKAQQSLELIQSKIVKAAGD-TTVIENSDVSPET---ESSEKETMSVS 790
Query: 1501 LNKQVAELN---KALEEEVAKTNEMQTALE 1527
LN+ V +L +A+ +++ K E LE
Sbjct: 791 LNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 820
Score = 95.9 bits (228), Expect = 1e-18
Identities = 170/863 (19%), Positives = 377/863 (43%), Gaps = 78/863 (9%)
Query: 481 VQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KL 537
++ + K+ +E + V+D++E+ ++ + QI Q + +I A + + HK+ K
Sbjct: 17 MESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD 76
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESD 597
KQ+++T D+ + D + EEL + L+ E LQ L + + E
Sbjct: 77 KQIKQTEDSLASERD---RLTSKEEELKDIQNMNFLLKAEVQKLQA-LANEQAAAAHE-- 130
Query: 598 VYKKMIEMENLAETRLKAI-SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC 656
+KM + + + +++ + L+ + + ++E IL + ++ ++ + L S+Q
Sbjct: 131 -LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPN 189
Query: 657 SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE 716
++ EQ++ K E +E L L+ G I+ KE+ +N ++ E
Sbjct: 190 KDV-----VEQMEKCIQEKDEKLKTVEEL-LET----GLIQ--VATKEEELNAIRT---E 234
Query: 717 NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
N LT +++ + A++ ++ EE K+ I E+D I+++E L
Sbjct: 235 NSSLTKEVQDLKAKQNDQVSFASLVEELKKV---------IHEKDGKIKSVEELLEAELL 285
Query: 777 RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV 836
++ E+++ +D + ++ +++G+ EK + S T + EL N L +
Sbjct: 286 KVANKEKTV---QDLKQEIKALKEEIGNVQLEKAQQLS-ITSKVQELQNLLKGKEEQMNT 341
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
++ L E E + K Q L EEN++L+ + ++ QH A++ + E +
Sbjct: 342 MKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK 401
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK------- 949
+ +L+ LE+ LK E ++ + K + ++D++ E N +S I K N +
Sbjct: 402 ENELKRLEAMLK----ERESDLSSKTQLLQDVQDE-NKLFKSQIEQLKQQNYQQASSFPP 456
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+E+ ++ +++ E ++ N +++L VE K N +L +K+ + + + TE+ +
Sbjct: 457 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALAS--TEKMLQ 514
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
+ K+N K++ +++ A+ + VS S L+ + L E++ +K
Sbjct: 515 D--KVNKTSKERQQQVEAVELEAKEVLKKLFPKVS-VPSNLS-YGEWLHGFEKK----AK 566
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ + +EE+++L + ++KE E ++ K + +++ T + +V+
Sbjct: 567 ECMAGTSGSEEVKVL----EHKLKEADEMHTLLQLECEKYKS-VLAETEGILQKLQRSVE 621
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
+KV E + I++ +Q EL+ ++ +E L E +
Sbjct: 622 -----QEENKWKVKVDESHKTIKQ---MQSSFTSSEQELERLRSENKDIENLRREREHLE 673
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ ++ + + + ++ D L +L S S AV Q E L K L +
Sbjct: 674 MELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN--EELNLLKAQLNETLTK 731
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRN 1308
+TE R +++ K +Q L+ +QS + +E S + + +KE +
Sbjct: 732 L-RTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 790
Query: 1309 LQEKYADVINQIEILRSEIEDEK 1331
L + + ++ + ++ EK
Sbjct: 791 LNQTVTQLQQLLQAVNQQLTKEK 813
Score = 55.6 bits (128), Expect = 1e-06
Identities = 125/629 (19%), Positives = 267/629 (42%), Gaps = 56/629 (8%)
Query: 216 QQMTKMQE-NFIAMEAEWKDEKQRLLKDIESKDVRISSL-EEANKLLEAARFEISLEHSK 273
Q TK +E N I E ++ + LK ++ V +SL EE K++ +I K
Sbjct: 220 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI-----K 274
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
+EL + KQ I+ EE ++ LE A +T K++ L++
Sbjct: 275 SVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ----LEKAQQLSITSKVQELQN 330
Query: 334 LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
L ++ +++ A + + K +++ K L + + + + +
Sbjct: 331 L---LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 387
Query: 394 LNQDTDKKI----NKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
+Q + +I +NE+ +LE +++ DL K ++ + K +
Sbjct: 388 ASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF------KSQIE 441
Query: 450 AQLQLEHQQHMEGP---SLIHVGTNTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
Q +QQ P L+ V + E +++ + + LK + + K N DL EK
Sbjct: 442 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN--DLREKN 499
Query: 506 KSAEEQIT----QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLT 561
A E + L D+++ +K + +L+ K++ K + F KVS + +
Sbjct: 500 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL--FPKVSVPSN--LSYG 555
Query: 562 EELHHLSQKVAE-LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLE 620
E LH +K E + G+ ++ ++++ ++ E+D ++++E E ++ E
Sbjct: 556 EWLHGFEKKAKECMAGTSGSEEVKVLEH---KLKEADEMHTLLQLE--CEKYKSVLAETE 610
Query: 621 SQKFDLVQELHILQQKYD-EVEDKLADISQLQSDQVCSEIKSVHLEEQ---IDALSASKK 676
L + + + K+ +V++ I Q+QS SE + L + I+ L ++
Sbjct: 611 GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE 670
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
L + +E ++++ +++L++ ++ KL + E + ++L + A+ ++E L
Sbjct: 671 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQ-LNETL 729
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME---DRRY 793
K+ EQ++ Q G K Q+ +E I+S++ K +E S E +
Sbjct: 730 TKL-RTEQNERQKVAGDLHKAQQS---LELIQSKIVKAAGDTTVIENSDVSPETESSEKE 785
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDE 822
++ +Q + LQ+ +A ++ +E E
Sbjct: 786 TMSVSLNQTVTQLQQLLQAVNQQLTKEKE 814
Score = 52.4 bits (120), Expect = 1e-05
Identities = 75/362 (20%), Positives = 153/362 (42%), Gaps = 33/362 (9%)
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ-----EE 1282
++QR ++ E +Q +E Q ++ Q A +++ +Q + + T EE
Sbjct: 9 LEQRLMQLMES-EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEE 67
Query: 1283 TNKIVTME--QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
+K++ + Q+ ++ L + + L + +E+ D+ N +L++E++ +
Sbjct: 68 LHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL------- 120
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
+L QS ++ + + EE Q + S+ + +E
Sbjct: 121 -ANEQAAAAHELEKMQQSVYVKDDK--IRLLEEQLQHEISNKMEEFKILNDQNKALKSEV 177
Query: 1401 KVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELA 1460
+ L+ T E + ++ ++ + Q DE ++L+E I+ T KE EL
Sbjct: 178 QKLQ-TLVSEQPNKDVVEQMEK----CIQEKDEKLKTVEELLE-TGLIQVAT--KEEELN 229
Query: 1461 ILRLKMHENANHYETMQ--KESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAK 1518
+R + + ++ + ++ L+EEL I E K V EL LE E+ K
Sbjct: 230 AIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL---LEAELLK 286
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+ +++ + EI L +EI N+Q + +A I V + +G++EQ+ NTM
Sbjct: 287 VANKEKTVQDLKQEIKALKEEIGNVQ-LEKAQQLSITSKVQELQNLLKGKEEQM-NTMKA 344
Query: 1579 EL 1580
L
Sbjct: 345 VL 346
Score = 35.1 bits (77), Expect = 2.1
Identities = 54/307 (17%), Positives = 125/307 (40%), Gaps = 21/307 (6%)
Query: 1273 DSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
D++ S Q E + ME NK + + ++++ E+ + QI+ S+I +
Sbjct: 1 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 60
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQM-----QEQSILNINEENAQLKKSSXXXXXX 1387
A +TE+ + +E+ + +I N LK
Sbjct: 61 ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 120
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ---LVEY 1444
++ E ++ + +KD +I + ++ + +EF+ + Q L
Sbjct: 121 ANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSE 176
Query: 1445 EKRIEDLTYEKESELAILRLK--MHENANHYETMQKESEIERVKLI---EELNVKITESV 1499
++++ L E+ ++ + +++ + E +T+++ E +++ EELN TE+
Sbjct: 177 VQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENS 236
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
SL K+V +L ++V+ + +E + I + +I +++ ++ A K+
Sbjct: 237 SLTKEVQDLKAKQNDQVS----FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEK 292
Query: 1560 FASDTKQ 1566
D KQ
Sbjct: 293 TVQDLKQ 299
>AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/d
protein.
Length = 1939
Score = 110 bits (264), Expect = 5e-23
Identities = 223/1110 (20%), Positives = 453/1110 (40%), Gaps = 104/1110 (9%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEE-------EKGNLQLHL-VD 587
K+K + K+ + ++++ +E + EEL K ELEE EK +LQL + +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 588 YDS--------GRMIESDVY--KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
DS ++I++ + K+ E+ AE + + L ++K L E L++
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 638 DEVEDKLADISQLQSDQVCSEIKSV-----HLEEQIDALSASKKEL----ALVIENLKLD 688
D++E LA + + + +++K++ L+E I L+ KK L +++L+ +
Sbjct: 959 DDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 689 KEQLYGTIK---DLENDKEDIMNKLQNYIQENMDLTD---------KLEKMSAEKISELL 736
++++ K LE +D+ L+ + MDL KL + SA I
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDK 1077
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
+++ + + K G+ +KI++ ++ ++ + ++RI LEE I R E
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 797 RKADQLGSYLQE----KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
++ L L+E ++A + Q + R A R +E+ L+ E L+
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 853 KKN---------QI--LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
KK+ QI L Q L+ S+M+ + L A+ K L
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257
Query: 902 DLESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
D S +K E Q LI ++ ++ E++ Q++ L+ + + +
Sbjct: 1258 DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIE 1317
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
+L+ QL+E + ++ + + ++ + +L+ + +++Q + ++ +++ N A
Sbjct: 1318 ELKRQLEE-EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE-LQRAMSKANSEVAQW 1375
Query: 1019 KQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ----LLD 1073
+ K E + I +++ A+ + D E + K ++E+ QR+ + ++D
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMID 1435
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
++ N L ++Q + K L E K E + E S +S + +
Sbjct: 1436 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES--RSLSTELFKIKNAYE 1493
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
LK +E + QE S L EQ A+ + E Q+E +EL Q
Sbjct: 1494 ESLDQLETLK-RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSEL-------Q 1545
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
+ + ++ LE + + + +++S + + ++ EI ++ + H+ E+
Sbjct: 1546 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-EETNKIV--TMEQVTSLQNKLQDKEEHL---- 1306
+ E+R + A K + D + Q N++ + + Q L+D + HL
Sbjct: 1606 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 1307 ---RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQ 1357
+L+E+ A V + +L++EIE+ + L T+N
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEI 1416
S +++ +I++ +++ + DA EL + + E
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 1417 YQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLK 1465
+K E T+ L R DE E + ++Q+ + E R+ +L E ESE A+ L+
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 1466 MHENANHYETMQKESEIERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQT 1524
HE T Q E + + + +++L K+ V S +Q E + ++K +Q
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 1525 ALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
LE E ++ L+ R +KI
Sbjct: 1906 ELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 109 bits (262), Expect = 8e-23
Identities = 221/1069 (20%), Positives = 445/1069 (41%), Gaps = 102/1069 (9%)
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC-------SE 658
E LA+T K L E + L+QE + LQ + D LAD + + DQ+ ++
Sbjct: 865 EELAKTEAKRKEL-EEKMVTLMQEKNDLQLQVQAEADSLADAEE-RCDQLIKTKIQLEAK 922
Query: 659 IKSV----HLEEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
IK V EE+I+A L+A K++L LK D + L T+ +E +K NK++N
Sbjct: 923 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 982
Query: 714 IQENMDLTDKLEKMSAEK--ISELLAKINHE---EQSKIQTQFGIDAKIQERDLYIENIE 768
+E L + + K++ EK + E + + E+ K+ T K++++ +E
Sbjct: 983 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1042
Query: 769 SELSKYKSRICR----LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
+ K + + R LE + + ++ +E QL L++K+ E + + ++
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQLDEKLKKKE---FEMSGLQSKIE 1099
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE-ENQNLQISLSDMQQHYNALVEKA 883
+ A+ M + +++ IE +E++ + + E Q +S ++++ L E
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAG 1158
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
T + K + + + + +L+ T +H+ +K+ D E QI++ R K
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1218
Query: 944 -KVLNEKYE---------KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI-DKH 992
K+ EK E N+E V++ + L++ +E+ ++ + LI D
Sbjct: 1219 QKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278
Query: 993 VQKQ--QTQSPDYTEQYINEINKLNALLKQKD---EEIIALNQKINNAQVSYMSMVSDYE 1047
Q+ QT+S +Y+ Q + ++ L + K ++I L +++ + ++ +
Sbjct: 1279 AQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQ 1338
Query: 1048 SKLAQFTTKLENMEEEMQ-RVSKQLLDSKQHNEELQILVREQDDQI---KELKETKLTFE 1103
S E EEE + + Q SK ++E Q + + D I +EL+E K
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 1104 MNIPKTEGMIISSTIEPMSDD------ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVL 1157
+ E + + + S + N V+ ++++ ++ +L
Sbjct: 1399 QRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDK-IL 1457
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
E K E + +L+TEL +E ++Q LE L EN NL +
Sbjct: 1458 AEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ----LETLKRENKNLQQEI 1513
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQ--------KTEHE----LRVQLSAFE 1265
++L I+ +R E+ ++ KQ + Q +++ Q EHE LR+QL +
Sbjct: 1514 SDLTEQIAEG-GKRIHELEKIKKQ-VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 1266 SKYE---QLLDSVQSSTQEETNKIVTMEQVTS-LQNKLQDKEEHLRNLQEKYADVINQIE 1321
K E ++ + + Q + N I +E + S L +++ + + +R L++K +N++E
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEGDLNEME 1630
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
I + L +S + ++EQ L + E A L ++
Sbjct: 1631 IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQ--LAMVERRANLLQAE 1688
Query: 1382 XXXXXXXXXXXXRVND-AEAKVLELTHQLEL---KDSEIYQKTHEYTITLTQRNDEFENV 1437
R AE ++L+ + +++L +++ + + ++Q E E++
Sbjct: 1689 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 1438 RQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE------IERVKLIEEL 1491
Q+ E++ + + L+ K + + H E M+K E R+ E+L
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 1492 NVK--ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL-------NDEITN 1542
+K + L +V EL +E E + E L E ++ L I
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR 1867
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLD--NTMNKELLDAVPRAEL 1589
LQ++V +K++ + A + ++ + L + EL +A RA++
Sbjct: 1868 LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADI 1916
Score = 95.9 bits (228), Expect = 1e-18
Identities = 201/1122 (17%), Positives = 446/1122 (39%), Gaps = 81/1122 (7%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ E ++ E K LE + E + L +++
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 907 ERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
A + E A + K L +G + + + E Q D ++
Sbjct: 966 AKVEKEKHATENKVKN---LTEEMAGLDETIAKLTKEKKALQEAHQQTLD------DLQA 1016
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
E + +L K + E + D D A+ +LE + S + +
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVD--DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIE 1074
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNV--KDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ + ++E K +E L +I+D L +K+K + +I +L +EI+A +
Sbjct: 1075 NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRA 1134
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
K + +++++ + + + + + ++ QK+ + E+ LQ H
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR-DLEEATLQ-HEAT 1192
Query: 588 YDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ R +D ++ E ++NL + K LE +K ++ E+ L + V +
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQK----LEKEKSEMKMEIDDLASNMETVSKAKGN 1248
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLENDK 703
+ +++C LE+Q+ + ++E +I +L + +L G ++K
Sbjct: 1249 L-----EKMCRA-----LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK 1298
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
+ ++++L + ++ ++I EL ++ E ++K + + + DL
Sbjct: 1299 DTLVSQL-----------SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL 1347
Query: 764 IENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E E E + K+ + R + ++ + + R E A Q L+E +K +
Sbjct: 1348 REQYEEE-QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK----------K 1396
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL--EENQNLQISLSDMQQHY--NA 878
L RL +H V + +E + LQ + + L+ E N + D +Q
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQ 935
L E + + +E Q + R L + L +I + ++ + Q K+E ++L+ E +
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516
Query: 936 IESAIRDKKVLN--EKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
E K ++ EK +K +E ++L+A L+E + ++E+ + + ++ L +
Sbjct: 1517 TEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSE 1575
Query: 993 VQKQQTQSPDYTEQY-INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
V ++ + + +Q N I + ++ D EI + N I + +++ E +L
Sbjct: 1576 VDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLN 1634
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
+ L D++ H L +R Q+D ++L + N+ + E
Sbjct: 1635 HANRMAAEALRNYRNTQAILKDTQLH---LDDALRSQEDLKEQL--AMVERRANLLQAEI 1689
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ +T+E ++ + + L + I + L+ +++ E+++
Sbjct: 1690 EELRATLE-QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ E + + E++ + + L NL TV +L+ + A +Q
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-EQL 1807
Query: 1232 GFEIAELWKQHLAQREADFQ-KTEHELRVQLSAFES--KYEQLLDSVQSSTQEETNKIVT 1288
+ + Q L R + + + E E + + A + K+E+ + + T+E+ I+
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR 1867
Query: 1289 MEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
++ V LQ K++ + +E+ +++ ++ E+E+
Sbjct: 1868 LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEE 1909
Score = 95.5 bits (227), Expect = 1e-18
Identities = 150/765 (19%), Positives = 318/765 (41%), Gaps = 50/765 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + +++L + E + KEL++K L++E +LQ+ + Q +
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV---QAEAD 900
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+L + R D + + +++++ + E + KK+++ED E I+
Sbjct: 901 SLADAEERCDQLIKTKIQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDID 959
Query: 938 SA-IRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 995 KQQT--QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T ++ EQ ++++ K+ ++ +K+ D E+ Q
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQ 1079
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KL+ E EM + ++ D + +LQ ++E +I+EL+E + K E
Sbjct: 1080 LDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 1113 I--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ + + E EF + R L+E A L E
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIE----MNKKREAEFQKMRRDLEE--ATLQHEATA 1193
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS---TVAELRSSISS 1226
+ +++ EL G + N +++ Q L+ + ++ E D+L S TV++ + ++
Sbjct: 1194 ATLRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS-TQEETNK 1285
+++E+ + Q+ T R+Q + E Y + LD + +Q K
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE--YSRQLDEKDTLVSQLSRGK 1309
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+Q+ L+ +L+++ + L + ++LR + E+E+ A
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEA--------KAEL 1361
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN-AKCASLEK 1420
Query: 1406 THQL---ELKDSEI-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES---E 1458
T Q E++D I ++T+ L ++ F+ + L E++++ E+ E E+ E
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI---LAEWKQKCEETHAELEASQKE 1477
Query: 1459 LAILRLKMHENANHYETMQKESEI---ERVKLIEELNVKITESVSLN-KQVAELNKALEE 1514
L ++ + N YE + E E L +E++ +TE ++ K++ EL K ++
Sbjct: 1478 SRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS-DLTEQIAEGGKRIHELEKIKKQ 1536
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ +E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1537 VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1581
Score = 94.3 bits (224), Expect = 3e-18
Identities = 182/967 (18%), Positives = 416/967 (43%), Gaps = 87/967 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ ++++L +A LE E SLE
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1043
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K + +LE+ LA++S +K +++EK + M+ L KIE
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLK----LAQESAMDIENDKQQLDEKLKKKEFEMSGLQSKIE 1099
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q+++ KEL+ ++ + E +A ++ S + K + + +++ +L
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1154
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
E T +I N+ K E Q + +DL +E + + T L
Sbjct: 1155 --EEAGGATSAQIEMNK--KREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAELG 1208
Query: 450 AQL--------QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD- 500
Q+ +LE ++ + + +N E V++ E++ + L D++ ++ K+
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 501 ----LIE-------KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK 549
LI +L++ + ++ DE D + + K +++++++ ++ K
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK 1328
Query: 550 VSDSNKEIVRLT-EELHHLSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMI 603
+ ++ + + L ++ E +E K LQ + +S E+D ++
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 604 EME----NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
E+E LA+ A +E+ Q+ +EVED + D+ + + +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
K + ++ + +E +E + + L + ++N E+ +++L+ +EN +
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508
Query: 720 LTDKLEKMSAEKISE------LLAKINHE-EQSKIQTQFGI---DAKIQERDLYIENIES 769
L ++ ++ E+I+E L KI + EQ K + Q + +A ++ + I I+
Sbjct: 1509 LQQEISDLT-EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQL 1567
Query: 770 ELSKYKS----RICRLEESIAVMEDRRYSL-ERKADQLGSYLQEKQKAYSEYTIQEDELV 824
EL++ KS +I +E I M+ + E L + ++ + A E +L
Sbjct: 1568 ELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL- 1626
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE----NQNLQISLSDMQQHYNALV 880
N + + ++H + + L + + K Q+ L++ ++L+ L+ +++ N L
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 881 EKAN--RTDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R L ++E ++ + L+++ + ++ H T ++ KK++E + ++E
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
I++ + EK +K I + +L++ ++ +L E K NLE K +Q +
Sbjct: 1747 DIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRL 1801
Query: 998 TQSPDYT-EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
++ + +I KL A +++ + E+ + QK N V + + +E K+ + T +
Sbjct: 1802 DEAEQLALKGGKKQIQKLEARVRELEGEVES-EQKRN---VEAVKGLRKHERKVKELTYQ 1857
Query: 1057 LENMEEEMQRVSKQL--LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
E + + R+ + L +K + + Q E+ + K ++ E+ + I
Sbjct: 1858 TEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917
Query: 1115 SSTIEPM 1121
S + +
Sbjct: 1918 ESQVNKL 1924
Score = 82.2 bits (194), Expect = 1e-14
Identities = 183/921 (19%), Positives = 380/921 (41%), Gaps = 95/921 (10%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+K+ +S LQ K++ + + LQ+KI E IE +
Sbjct: 1076 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A A+ + K+R + E + +R LEEA EA
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1191
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIE-PSCEEKTEIEEKGS-LEIAN 320
+ +H+ EL + KQ +E E K EI++ S +E +
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR-N 377
+ L K LE +I+ +E + + + + + + S + S + K +
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q E L + +++I + + DL+ ++Y E+
Sbjct: 1304 QLSRGKQAFTQ-QIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY--EEEQEAKAE 1360
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
++ +AQ + +++ TE++ E K Q Q+ + ++ VN
Sbjct: 1361 LQRAMSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 498 VK-DLIEKLKS-AEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSKVS 551
K +EK K + ++ L +++ N K ++ K+ + QK + +++
Sbjct: 1413 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1472
Query: 552 DSNKEIVRLTEELHHLSQKVAE-------LEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
S KE L+ EL + E L+ E NLQ + D + ++ E K++ E
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL-TEQIAEGG--KRIHE 1529
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI--KSV 662
+E + + +E +K +L L + + E K+ I QL+ +QV SE+ K
Sbjct: 1530 LEKIKKQ-------VEQEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIA 1581
Query: 663 HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
+E+ID + K+ ++E++ + L I+ ND + K++ + E +
Sbjct: 1582 EKDEEIDQM---KRNHIRIVESM---QSTLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLN 1634
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
+M+A E L + + TQ +D ++ + E+++ +L+ + R L+
Sbjct: 1635 HANRMAA----EALRNYRNTQAILKDTQLHLDDALRSQ----EDLKEQLAMVERRANLLQ 1686
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
I + ER L + + Q L+N L ++ ++
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 843 EI--EHENKELQKKNQIL--------LEENQNLQISLSDMQQHYNALV-EKANRTDLAES 891
+I E N E + K I L++ Q+ L M+++ V + +R D AE
Sbjct: 1747 DIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806
Query: 892 ESTK-YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ K + Q++ LE+ ++ + E ++ ++K+ +E ++ + E +++ E+
Sbjct: 1807 LALKGGKKQIQKLEARVRELEGEVES---EQKRNVE--AVKGLRKHERKVKELTYQTEED 1861
Query: 951 EKNI----EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
KNI + V +L+A+++ YK E EE + +NL + +Q + ++ + +
Sbjct: 1862 RKNILRLQDLVDKLQAKVKSYKRQAE----EAEEQSNVNLSKF-RRIQHELEEAEERADI 1916
Query: 1007 YINEINKLNALLKQKDEEIIA 1027
+++NKL ++ +II+
Sbjct: 1917 AESQVNKLRVKSREVHTKIIS 1937
>BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1,
skeletal muscle, adult protein.
Length = 1939
Score = 109 bits (262), Expect = 8e-23
Identities = 223/1110 (20%), Positives = 456/1110 (41%), Gaps = 104/1110 (9%)
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEE-------EKGNLQLHL-VD 587
K+K + K+ + ++++ +E + EEL K ELEE EK +LQL + +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 588 YDS--------GRMIESDVY--KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
DS ++I++ + K+ E+ AE + + L ++K L E L++
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 638 DEVEDKLADISQLQSDQVCSEIKSV-----HLEEQIDALSASKKEL----ALVIENLKLD 688
D++E LA + + + +++K++ L+E I L+ KK L +++L+ +
Sbjct: 959 DDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 689 KEQLYGTIK---DLENDKEDIMNKLQNYIQENMDL---TDKLE---KMSAEKISEL---L 736
++++ K LE +D+ L+ + MDL KLE K++ E ++
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDK 1077
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
+++ + + K G+ +KI++ ++ ++ + ++RI LEE I R E
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 797 RKADQLGSYLQE----KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
++ L L+E ++A + Q + R A R +E+ L+ E L+
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 853 KKN---------QI--LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
KK+ QI L Q L+ S+M+ + L A+ K L
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257
Query: 902 DLESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
D S +K E Q LI ++ ++ E++ Q++ L+ + + +
Sbjct: 1258 DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIE 1317
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
+L+ QL+E + ++ + + ++ + +L+ + +++Q + ++ +++ N A
Sbjct: 1318 ELKRQLEE-EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE-LQRAMSKANSEVAQW 1375
Query: 1019 KQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ----LLD 1073
+ K E + I +++ A+ + D E + K ++E+ QR+ + ++D
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMID 1435
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
++ N L ++Q + K L E K E + E S +S + +
Sbjct: 1436 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES--RSLSTELFKIKNAYE 1493
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
LK +E + QE S L EQ A+ + E Q+E +EL Q
Sbjct: 1494 ESLDQLETLK-RENKNLQQEISDLTEQIAEGGKRIHELKKIKKQVEQEKSEL-------Q 1545
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
+ + ++ LE + + + +++S + + ++ EI ++ + H+ E+
Sbjct: 1546 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-EETNKIV--TMEQVTSLQNKLQDKEEHL---- 1306
+ E+R + A K + D + Q N++ + + Q L+D + HL
Sbjct: 1606 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 1307 ---RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQ 1357
+L+E+ A V + +L++EIE+ + L T+N
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEI 1416
S +++ +I++ +++ + DA EL + + E
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 1417 YQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLK 1465
+K E T+ L R DE E + ++Q+ + E R+ +L E ESE A+ L+
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 1466 MHENANHYETMQKESEIERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQT 1524
HE T Q E + + + +++L K+ V S +Q E + ++K +Q
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 1525 ALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
LE E ++ L+ R +KI
Sbjct: 1906 ELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 109 bits (262), Expect = 8e-23
Identities = 221/1069 (20%), Positives = 445/1069 (41%), Gaps = 102/1069 (9%)
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC-------SE 658
E LA+T K L E + L+QE + LQ + D LAD + + DQ+ ++
Sbjct: 865 EELAKTEAKRKEL-EEKMVTLMQEKNDLQLQVQAEADSLADAEE-RCDQLIKTKIQLEAK 922
Query: 659 IKSV----HLEEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
IK V EE+I+A L+A K++L LK D + L T+ +E +K NK++N
Sbjct: 923 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 982
Query: 714 IQENMDLTDKLEKMSAEK--ISELLAKINHE---EQSKIQTQFGIDAKIQERDLYIENIE 768
+E L + + K++ EK + E + + E+ K+ T K++++ +E
Sbjct: 983 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1042
Query: 769 SELSKYKSRICR----LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
+ K + + R LE + + ++ +E QL L++K+ E + + ++
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE---FEMSGLQSKIE 1099
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE-ENQNLQISLSDMQQHYNALVEKA 883
+ A+ M + +++ IE +E++ + + E Q +S ++++ L E
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAG 1158
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
T + K + + + + +L+ T +H+ +K+ D E QI++ R K
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1218
Query: 944 -KVLNEKYE---------KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI-DKH 992
K+ EK E N+E V++ + L++ +E+ ++ + LI D
Sbjct: 1219 QKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278
Query: 993 VQKQ--QTQSPDYTEQYINEINKLNALLKQKD---EEIIALNQKINNAQVSYMSMVSDYE 1047
Q+ QT+S +Y+ Q + ++ L + K ++I L +++ + ++ +
Sbjct: 1279 AQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQ 1338
Query: 1048 SKLAQFTTKLENMEEEMQ-RVSKQLLDSKQHNEELQILVREQDDQI---KELKETKLTFE 1103
S E EEE + + Q SK ++E Q + + D I +EL+E K
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 1104 MNIPKTEGMIISSTIEPMSDD------ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVL 1157
+ E + + + S + N V+ ++++ ++ +L
Sbjct: 1399 QRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDK-IL 1457
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
E K E + +L+TEL +E ++Q LE L EN NL +
Sbjct: 1458 AEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ----LETLKRENKNLQQEI 1513
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQ--------KTEHE----LRVQLSAFE 1265
++L I+ +R E+ ++ KQ + Q +++ Q EHE LR+QL +
Sbjct: 1514 SDLTEQIAEG-GKRIHELKKIKKQ-VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 1266 SKYE---QLLDSVQSSTQEETNKIVTMEQVTS-LQNKLQDKEEHLRNLQEKYADVINQIE 1321
K E ++ + + Q + N I +E + S L +++ + + +R L++K +N++E
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEGDLNEME 1630
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
I + L +S + ++EQ L + E A L ++
Sbjct: 1631 IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQ--LAMVERRANLLQAE 1688
Query: 1382 XXXXXXXXXXXXRVND-AEAKVLELTHQLEL---KDSEIYQKTHEYTITLTQRNDEFENV 1437
R AE ++L+ + +++L +++ + + ++Q E E++
Sbjct: 1689 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 1438 RQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE------IERVKLIEEL 1491
Q+ E++ + + L+ K + + H E M+K E R+ E+L
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 1492 NVK--ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL-------NDEITN 1542
+K + L +V EL +E E + E L E ++ L I
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR 1867
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQGRDEQLD--NTMNKELLDAVPRAEL 1589
LQ++V +K++ + A + ++ + L + EL +A RA++
Sbjct: 1868 LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADI 1916
Score = 95.9 bits (228), Expect = 1e-18
Identities = 201/1122 (17%), Positives = 446/1122 (39%), Gaps = 81/1122 (7%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
AE + E + ++ E ++ E K LE + E + L +++
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L K I+ + K E+ E+ E ELT K LE ++++ +LE L
Sbjct: 907 ERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAK 409
A + E A + K L +G + + + E Q D ++
Sbjct: 966 AKVEKEKHATENKVKN---LTEEMAGLDETIAKLTKEKKALQEAHQQTLD------DLQA 1016
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
E + +L K + E + D D A+ +LE + S + +
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVD--DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNV--KDLIEKLKSAEEQITQLNDEIDAANKNMI 527
+ + ++E K +E L +I+D L +K+K + +I +L +EI+A +
Sbjct: 1075 NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRA 1134
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
K + +++++ + + + + + ++ QK+ + E+ LQ H
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR-DLEEATLQ-HEAT 1192
Query: 588 YDSGRMIESDVYKKMIE-MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ R +D ++ E ++NL + K LE +K ++ E+ L + V +
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQK----LEKEKSEMKMEIDDLASNMETVSKAKGN 1248
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLENDK 703
+ +++C LE+Q+ + ++E +I +L + +L G ++K
Sbjct: 1249 L-----EKMCRA-----LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK 1298
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
+ ++++L + ++ ++I EL ++ E ++K + + + DL
Sbjct: 1299 DTLVSQL-----------SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL 1347
Query: 764 IENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E E E + K+ + R + ++ + + R E A Q L+E +K +
Sbjct: 1348 REQYEEE-QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK----------K 1396
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL--EENQNLQISLSDMQQHY--NA 878
L RL +H V + +E + LQ + + L+ E N + D +Q
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQ 935
L E + + +E Q + R L + L +I + ++ + Q K+E ++L+ E +
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516
Query: 936 IESAIRDKKVLNE--KYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
E K ++E K +K +E ++L+A L+E + ++E+ + + ++ L +
Sbjct: 1517 TEQIAEGGKRIHELKKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSE 1575
Query: 993 VQKQQTQSPDYTEQY-INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
V ++ + + +Q N I + ++ D EI + N I + +++ E +L
Sbjct: 1576 VDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLN 1634
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
+ L D++ H L +R Q+D ++L + N+ + E
Sbjct: 1635 HANRMAAEALRNYRNTQAILKDTQLH---LDDALRSQEDLKEQL--AMVERRANLLQAEI 1689
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ +T+E ++ + + L + I + L+ +++ E+++
Sbjct: 1690 EELRATLE-QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ E + + E++ + + L NL TV +L+ + A +Q
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA-EQL 1807
Query: 1232 GFEIAELWKQHLAQREADFQ-KTEHELRVQLSAFES--KYEQLLDSVQSSTQEETNKIVT 1288
+ + Q L R + + + E E + + A + K+E+ + + T+E+ I+
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR 1867
Query: 1289 MEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
++ V LQ K++ + +E+ +++ ++ E+E+
Sbjct: 1868 LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEE 1909
Score = 95.5 bits (227), Expect = 1e-18
Identities = 150/765 (19%), Positives = 318/765 (41%), Gaps = 50/765 (6%)
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
++ E +A + + +++L + E + KEL++K L++E +LQ+ + Q +
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV---QAEAD 900
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+L + R D + + +++++ + E + KK+++ED E I+
Sbjct: 901 SLADAEERCDQLIKTKIQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDID 959
Query: 938 SA-IRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
+ KV EK+ E ++ +T+ A L E + ++E ++ L+ +
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 995 KQQT--QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
K T ++ EQ ++++ K+ ++ +K+ D E+ Q
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQ 1079
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
KL+ E EM + ++ D + +LQ ++E +I+EL+E + K E
Sbjct: 1080 LDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 1113 I--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
+S +E +S+ + + E EF + R L+E A L E
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIE----MNKKREAEFQKMRRDLEE--ATLQHEATA 1193
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS---TVAELRSSISS 1226
+ +++ EL G + N +++ Q L+ + ++ E D+L S TV++ + ++
Sbjct: 1194 ATLRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS-TQEETNK 1285
+++E+ + Q+ T R+Q + E Y + LD + +Q K
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE--YSRQLDEKDTLVSQLSRGK 1309
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+Q+ L+ +L+++ + L + ++LR + E+E+ A
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEA--------KAEL 1361
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+E ++ E + EE + KK VN A+ LE
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN-AKCASLEK 1420
Query: 1406 THQL---ELKDSEI-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES---E 1458
T Q E++D I ++T+ L ++ F+ + L E++++ E+ E E+ E
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI---LAEWKQKCEETHAELEASQKE 1477
Query: 1459 LAILRLKMHENANHYETMQKESEI---ERVKLIEELNVKITESVSLN-KQVAELNKALEE 1514
L ++ + N YE + E E L +E++ +TE ++ K++ EL K ++
Sbjct: 1478 SRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS-DLTEQIAEGGKRIHELKKIKKQ 1536
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ +E+Q ALE E + +I +Q + S++ + ++
Sbjct: 1537 VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1581
Score = 94.3 bits (224), Expect = 3e-18
Identities = 179/966 (18%), Positives = 412/966 (42%), Gaps = 85/966 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLE 270
++M + E + E K + Q+ L D+++++ ++++L +A LE E SLE
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1043
Query: 271 HSK-LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
K + +LE+ LA++S +K +++EK + M+ L KIE
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLK----LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIE 1099
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQL 389
+ L Q+++ KEL+ ++ + E +A ++ S + K + + +++ +L
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEA-----ERASRAKAEKQRSDLSRELEEISERL 1154
Query: 390 SSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
E T +I N+ K E Q + +DL +E + + T L
Sbjct: 1155 --EEAGGATSAQIEMNK--KREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAELG 1208
Query: 450 AQL--------QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD- 500
Q+ +LE ++ + + +N E V++ E++ + L D++ ++ K+
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 501 ----LIE-------KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK 549
LI +L++ + ++ DE D + + K +++++++ ++ K
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK 1328
Query: 550 VSDSNKEIVRLT-EELHHLSQKVAELEEEKGNLQLHLVDYDS-----GRMIESDVYKKMI 603
+ ++ + + L ++ E +E K LQ + +S E+D ++
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 604 EME----NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
E+E LA+ A +E+ Q+ +EVED + D+ + + +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
K + ++ + +E +E + + L + ++N E+ +++L+ +EN +
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508
Query: 720 LTDKLEKMS------AEKISELLAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESE 770
L ++ ++ ++I EL EQ K + Q + +A ++ + I I+ E
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELKKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 771 LSKYKS----RICRLEESIAVMEDRRYSL-ERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
L++ KS +I +E I M+ + E L + ++ + A E +L N
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL-N 1627
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE----NQNLQISLSDMQQHYNALVE 881
+ + ++H + + L + + K Q+ L++ ++L+ L+ +++ N L
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687
Query: 882 KAN--RTDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
+ R L ++E ++ + L+++ + ++ H T ++ KK++E + ++E
Sbjct: 1688 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED 1747
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
I++ + EK +K I + +L++ ++ +L E K NLE K +Q +
Sbjct: 1748 IIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL-----ERMKKNLEQTVKDLQHRLD 1802
Query: 999 QSPDYT-EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
++ + +I KL A +++ + E+ + QK N V + + +E K+ + T +
Sbjct: 1803 EAEQLALKGGKKQIQKLEARVRELEGEVES-EQKRN---VEAVKGLRKHERKVKELTYQT 1858
Query: 1058 ENMEEEMQRVSKQL--LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
E + + R+ + L +K + + Q E+ + K ++ E+ + I
Sbjct: 1859 EEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAE 1918
Query: 1116 STIEPM 1121
S + +
Sbjct: 1919 SQVNKL 1924
Score = 82.2 bits (194), Expect = 1e-14
Identities = 179/914 (19%), Positives = 374/914 (40%), Gaps = 81/914 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+K+ +S LQ K++ + + LQ+KI E IE +
Sbjct: 1076 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A A+ + K+R + E + +R LEEA EA
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 1191
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIE-PSCEEKTEIEEKGS-LEIAN 320
+ +H+ EL + KQ +E E K EI++ S +E +
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR-N 377
+ L K LE +I+ +E + + + + + + S + S + K +
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q E L + +++I + + DL+ ++Y E+
Sbjct: 1304 QLSRGKQAFTQ-QIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY--EEEQEAKAE 1360
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
++ +AQ + +++ TE++ E K Q Q+ + ++ VN
Sbjct: 1361 LQRAMSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 498 VK-DLIEKLKS-AEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSKVS 551
K +EK K + ++ L +++ N K ++ K+ + QK + +++
Sbjct: 1413 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1472
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAET 611
S KE L+ EL + EE L+ + + + SD+ +++ E
Sbjct: 1473 ASQKESRSLSTELFKIKN---AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1529
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI--KSVHLEEQID 669
K +E +K +L L + + E K+ I QL+ +QV SE+ K +E+ID
Sbjct: 1530 LKKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIAEKDEEID 1588
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+ K+ ++E++ + L I+ ND + K++ + E + +M+A
Sbjct: 1589 QM---KRNHIRIVESM---QSTLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1641
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
E L + + TQ +D ++ + E+++ +L+ + R L+ I +
Sbjct: 1642 ----EALRNYRNTQAILKDTQLHLDDALRSQ----EDLKEQLAMVERRANLLQAEIEELR 1693
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI--EHE 847
ER L + + Q L+N L ++ ++ +I E
Sbjct: 1694 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEAR 1753
Query: 848 NKELQKKNQIL--------LEENQNLQISLSDMQQHYNALV-EKANRTDLAESESTK-YQ 897
N E + K I L++ Q+ L M+++ V + +R D AE + K +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI--- 954
Q++ LE+ ++ + E ++ ++K+ +E ++ + E +++ E+ KNI
Sbjct: 1814 KQIQKLEARVRELEGEVES---EQKRNVE--AVKGLRKHERKVKELTYQTEEDRKNILRL 1868
Query: 955 -EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
+ V +L+A+++ YK E EE + +NL + +Q + ++ + + +++NK
Sbjct: 1869 QDLVDKLQAKVKSYKRQAE----EAEEQSNVNLSKF-RRIQHELEEAEERADIAESQVNK 1923
Query: 1014 LNALLKQKDEEIIA 1027
L ++ +II+
Sbjct: 1924 LRVKSREVHTKIIS 1937
>AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome associated
protein protein.
Length = 2442
Score = 107 bits (258), Expect = 2e-22
Identities = 185/869 (21%), Positives = 380/869 (43%), Gaps = 69/869 (7%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++L ++ +++ QL + D + + L Q QK +++ K+ + +E V
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
Query: 559 RLTEELH-HLSQKVAEL----EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL 613
+ E H L + A L +EEK +LQ + D + E D + +EN E
Sbjct: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGLENSLELES 373
Query: 614 KAISLLESQKFDLVQEL--HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
S + Q D L +L ++ V+D ++ Q + + EE+ AL
Sbjct: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
++L + L L G + L ++E ++ K + +++ +++ ++ E +
Sbjct: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE-LLQKAREELRQQLEVLEQ-EAWRLRR 491
Query: 732 IS-ELLAKINHEEQSKIQTQFGIDAKIQERDLYIE---NIESELSKYKSRICRLEESIAV 787
++ EL + + + K + Q + ++ER+ E +E++ S+ S + L E++
Sbjct: 492 VNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALES 551
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL-------------MDHD 834
+ L ++ ++ + L +++ +E + E+ L +A L + D
Sbjct: 552 IHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD 611
Query: 835 RV-VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+V + +QLL++E EN+ + + + + LQ+ L++ ++ AL EK T L E++
Sbjct: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK--NTHL-EAQL 668
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
K + +L+++L+ I E + I +K E + TQ+E ++ K E +
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEE-IQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS-PDYTEQYINEIN 1012
++ + EA ++E K +E + + E ++ +L Q Q S + E + E
Sbjct: 728 VQ---EKEALVRE-KAALE-VRLQAVERDRQDLA-----AQLQGLSSAKELLESSLFEAQ 777
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
+ N+++ + ++ Q + A+ V + +L T+ E+E ++QL
Sbjct: 778 QQNSVIDEPQGQLEVQIQTVTQAKEVIQGEVRCLKLEL---DTERSQAEQERDAAARQLA 834
Query: 1073 DSKQHNE-ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
++Q + L+ + ++ +L+E K E + + E ++ +E + + ++
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLRE-KWEKERSWHQQE---LAKALESLEREKMELEMR 890
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTGHDV 1190
++ Q EEE Q S L + +L TE + ++ LET L T+ D
Sbjct: 891 LKEQQTEMEAIQAQREEERTQAESALCQM--QLETEKE----RVSLLETLLQTQKELADA 944
Query: 1191 VNQEQINQLKSKLEQL-NTENDNLLST-VAELRSSISSAVDQRGFEIAELWKQ--HLAQR 1246
Q + + K+++L E +L T + E + + A Q ++A L ++ L Q
Sbjct: 945 SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE--ETNKI--VTMEQVTSLQNKLQDK 1302
+ D QK +L+ QL A + + VQ +E E N+I + SL L +K
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 1303 EEHLRNLQEKYADVINQIEI--LRSEIED 1329
E+ L LQE AD I Q E+ LR ++++
Sbjct: 1065 EQRLLVLQE--ADSIRQQELSALRQDMQE 1091
Score = 85.8 bits (203), Expect = 1e-15
Identities = 120/611 (19%), Positives = 270/611 (44%), Gaps = 33/611 (5%)
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIV 558
DL E+ + + Q +Q++D +++ + + + ++K ++ I+ + + +++
Sbjct: 1596 DLEERSQELQAQSSQIHD-LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLV-DYDSGRMIESDVYKKMIEMENLAETRLK-AI 616
R +EL +++ LE+++ L D + ++ + +++ L + R +
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKSVHLEEQIDALSAS 674
++Q+ L IL+ K EVE + I +LQ DQ+ +++ +H + +L S
Sbjct: 1715 GPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKMSAEKIS 733
++E +V+ +L + + G +K+ LQ+ + E L + +++ A +
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKE---------QSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+ A+ EE+ K + + +++ + ++ EL +K + RLEE +AV R
Sbjct: 1826 QQQAQ-GQEERVKEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQ 1883
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
+LE L + +E++KA Q E V R ++ L+ + KE +
Sbjct: 1884 ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV---ETRALQDSWLQAQAVLKERDQ 1940
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ + L E+Q+ + + AL E + A ++ + +L +L+ T
Sbjct: 1941 ELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTAT 2000
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
Q + + LE Q E I+D+ + +Y+++++ + Q AQ E + +
Sbjct: 2001 LQASLDACQAHSRQLEEALRIQ-EGEIQDQDL---RYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI----NEINKLNALLKQKDEEIIALN 1029
+E+ ++ + +Q++Q + E+ I + +L L QK++EI+ L
Sbjct: 2057 REQLLEKSLAQRVQ--ENMIQEKQNLGLEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ- 1088
+ + + S S + + + KL+++E +QR ++L + + E +I RE+
Sbjct: 2115 ETQQRNNLEALPH-SHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKA 2173
Query: 1089 DDQIKELKETK 1099
D L +TK
Sbjct: 2174 QDLALSLAQTK 2184
Score = 80.6 bits (190), Expect = 4e-14
Identities = 235/1185 (19%), Positives = 463/1185 (39%), Gaps = 96/1185 (8%)
Query: 417 LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDV 475
L + + +KE ++ EK + L AQLQ L + + SL +
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAAQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 476 NEIAKVQEQLKQELNDEIKDVNVKDLIEKLK-SAEEQITQLNDEIDAANKNMIKVKSNHK 534
+E + Q +++ + + K+V ++ + LK + + +Q E DAA + + + + K
Sbjct: 784 DE-PQGQLEVQIQTVTQAKEV-IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RM 593
L+Q + + E R + L++ + LE EK L++ L + +
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQ-QELAKALESLEREKMELEMRLKEQQTEMEA 900
Query: 594 IESDVYKKMIEMENLA-----ETRLKAISLLES----QK--FDLVQELHILQQ--KYDEV 640
I++ ++ + E+ ET + +SLLE+ QK D Q+L L+Q K ++
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
Query: 641 -EDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK--EQLYGTIK 697
E + I Q Q + E+K + + D + ++ +L+ + + L K E L +
Sbjct: 961 KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 698 DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
++ + + ++Q ++E + +++ EK S L + +EQ + Q +
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS-LTLSLMEKEQRLLVLQEADSIRQ 1079
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
QE ++++ + K ++E R+ E++AD L Q ++ + +
Sbjct: 1080 QELSALRQDMQEAQGEQKELSAQMELL------RQEVKEKEADFLAQEAQLLEELEASH- 1132
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS--LSDMQQH 875
I E +L L + +L E + + L + Q + Q++ S +QQ
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLHLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE-IEDLEIEFNT 934
++ E +R +L+ + + + N R + L+ E + ++ +
Sbjct: 1193 LGSVCE--SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALLKLHQ 1250
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL----NMNVEELNK------- 983
+ + + VL ++ +K E +T EA+ + +++L + N EE +K
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNS 1310
Query: 984 MNLELIDKHVQKQQTQSP-DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ EL++ H QS E E LL+ E + A + + A V +
Sbjct: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ 1370
Query: 1043 VS-----DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV-REQDDQIKELK 1096
S + + + A+ KL+N E E +R Q L Q EL++ + + + L
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQAL---QEQGELKVAQGKALQENLALLT 1427
Query: 1097 ETKLTFEMNIPKTEGMIISSTIE-PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
+T E + G I + M A + L+ ++ +E + RS
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS 1487
Query: 1156 VL-------QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL----KSKLE 1204
VL QE+ KL + ++ ET L H ++ E+ +Q+ + +++
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIREPEKDRETQRNVLE-HQLLELEKKDQMIESQRGQVQ 1546
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA------DFQKTEHELR 1258
L + L EL + Q+ I EL Q QR A D ++ EL+
Sbjct: 1547 DLKKQLVTLECLALELEENHHKMECQQKL-IKELEGQRETQRVALTHLTLDLEERSQELQ 1605
Query: 1259 VQLSAF---ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
Q S ES L +Q QE ++ EQ+ LQ + + + L ++
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQ---REQIEELQRQKEHLTQDLERRDQELML 1662
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
+I++L + + +L T+ Q ++ E+ +
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
L+ + ++ EL QLE + +++K E ++ L+QR E
Sbjct: 1723 SLEHMKLILRDKEKEVECQQEHIH-ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 1436 NVRQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVK---- 1486
++QQL E ++ E +S+L A+ + A E Q + + ERVK
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 1487 ----LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
+E+ ++ + E + E + LEEE+A ALE
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Score = 79.0 bits (186), Expect = 1e-13
Identities = 191/1090 (17%), Positives = 434/1090 (39%), Gaps = 81/1090 (7%)
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+++L ++L Q L ++ L+ L D ++ + S V+ ++ +++ +
Sbjct: 1245 LLKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEK---SQVHTELQDLQRQLSQNQEEK 1301
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKL--ADISQL--QSDQVCSEIKSVHLEEQIDALS 672
S E ++ L EL L + ++ +L A++ ++ Q ++ + +L Q++ L
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY--IQENMDLTDKLEKMSAE 730
A+ E + +E L L+ E++ ++ + +QE +L K E
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
++ LL + E + +++T G +IQE + E ++ L + + + + + ++
Sbjct: 1422 NLA-LLTQTLAEREEEVETLRG---QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQE 1477
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ LE+ L Q+ + T+Q +++ + DR ++ +LE H+ E
Sbjct: 1478 QIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREP-----EKDRETQRNVLE--HQLLE 1530
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN--LK 908
L+KK+Q++ E+Q Q+ D+++ L A + + Q +++LE +
Sbjct: 1531 LEKKDQMI--ESQRGQVQ--DLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQ 1586
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
R+ H TL ++++ + +L+ + ++QI VL + ++ + V Q++E +
Sbjct: 1587 RVALTHLTLDLEERSQ--ELQAQ-SSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
E+L ++E ++ L L + +Q + Q T+ ++ ++ L+++ E+
Sbjct: 1644 RQKEHLTQDLERRDQ-ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ 1702
Query: 1029 NQ-------------KINNAQVSYMSMV-SDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
Q K + +M ++ D E ++ + ++E ++ +QL
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV--DXXX 1132
+ E +L+ +++ +I L++ ++ + +G + +++ D+A
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQ-----QLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 1133 XXXXXXXXXLKVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
+ Q +EE ++E++ LQ + + L+E + ++ + L V
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL---WKQH---LAQ 1245
++ L+ L L E+ + L+ + + E L W Q L +
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937
Query: 1246 RE-------ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
R+ A+ Q + H+ + E+ E L + + +E + + E SL+
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
+ L Q + + I EI+D+ + + +LR Q
Sbjct: 1998 TATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELR-HQQE 2056
Query: 1359 YKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQ 1418
+Q+ E+S+ +EN +K + + V EL L K+ EI
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQN----LGLEREEEEIRGLHQSVRELQLTLAQKEQEIL- 2111
Query: 1419 KTHEYTITLTQRNDE---FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE-NANHYE 1474
E T + N E + + E +++ L + EL L+ + + A E
Sbjct: 2112 ---ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE 2168
Query: 1475 TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
+K ++ + +V + V++ Q + L + E++ + +E++ E E +
Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ-DELELTRRALEKERL 2227
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVS--FASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+ + R VS A + G ++Q + L AV R E+D +
Sbjct: 2228 HSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287
Query: 1593 MYMLHQRDVR 1602
H +R
Sbjct: 2288 RLQRHNVQLR 2297
Score = 65.3 bits (152), Expect = 2e-09
Identities = 191/997 (19%), Positives = 405/997 (40%), Gaps = 112/997 (11%)
Query: 151 IKEKD--NALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXX 208
I E+D A S L++K + +E+ + + + E+ ++ A+ KA
Sbjct: 1376 ILEEDLRTARSALKLKNEEVESE-RERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 209 XXXEDTK---QQMTKMQE-NFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + Q++ K +E A+E D K+R ++++ + +I LE+ +LE
Sbjct: 1435 EEVETLRGQIQELEKQREMQKAALELLSLDLKKRN-QEVDLQQEQIQELEKCRSVLEHLP 1493
Query: 265 FEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE-----IA 319
+ KL + EQ L Q +E +++ ++G ++ +
Sbjct: 1494 MAVQEREQKLTVQREQIREPEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553
Query: 320 NMTELTKKIELLEH-LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
+ L ++E H + CQ ++ KELE + T ++ ++ S + +S +
Sbjct: 1554 TLECLALELEENHHKMECQ-QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-- 1610
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDL--------VDKEYV--- 427
++S + L+ E +D + K + +I +L+ + L +DL + KE +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 428 ---------ISEKDTXXXXXXXXXXGKD-TLIAQLQLEHQQHMEGPS------LIHVGTN 471
I E+D G++ T QL E + +GPS L H+
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 472 TEDVN-EIAKVQEQLK--QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
D E+ QE + QEL D+++ ++ L K+ ++Q EI + + +
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQ-QLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY 588
+ +LK + +Q +D ++ + + + +EL L Q+ + + ++ ++
Sbjct: 1790 AREQGELKEQSLQSQLD------EAQRALAQRDQELEALQQEQQQAQGQEERVKE----- 1838
Query: 589 DSGRMIESDVYKKMIEMENLA-ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
++D + +E ++ + R + + Q L +EL + ++ +E+ L D+
Sbjct: 1839 ------KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+Q E + L++Q A A + E +E L L E D+E +
Sbjct: 1893 RAESREQ---EKALLALQQQC-AEQAQEHE----VETRALQDSWLQAQAVLKERDQE--L 1942
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
L+ Q + ++ + AE + E L K + Q K Q + + +
Sbjct: 1943 EALRAESQSSRH-QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 768 ESELSKYKSRICRLEESIAVME----DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
++ L ++ +LEE++ + E D+ + QL L ++ + +E L
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
LA + + + EKQ L +E E +E++ +Q + E LQ++L+ +Q L E
Sbjct: 2062 EKSLAQRVQENMIQEKQNLGLEREEEEIRGLHQSVRE----LQLTLAQKEQEILELRETQ 2117
Query: 884 NRTDLA----ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
R +L +++ + Q L+S R+ E + L + + E EIE+ + +
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR-QTEAREIEWREKAQDL 2176
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
E L+A + E + + L +EL EL + ++K++
Sbjct: 2177 ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ---DEL-----ELTRRALEKERLH 2228
Query: 1000 SPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
SP T A L + E+ + L + ++ + + +S + +LE+
Sbjct: 2229 SPGATS---------TAELGSRGEQGVQLGE-VSGVEAEPSPDGMEKQS----WRQRLEH 2274
Query: 1060 MEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+++ + R+ ++HN +L+ + + + + ++LK
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Score = 57.2 bits (132), Expect = 5e-07
Identities = 148/749 (19%), Positives = 291/749 (38%), Gaps = 66/749 (8%)
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM---QQHYNALVEK 882
+L +L+ + +EK+ E E +L+ + + E Q+ LS + Q N EK
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 883 ANRT--DLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE--S 938
+ + E T + T+L + E++L R E + + Q K+I + +E I S
Sbjct: 305 MIKALRETVEILETNH-TELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS 363
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
+ + L +Y + L ++ + V++L + L + V Q
Sbjct: 364 GLENSLELESSIFSQFDY-QDADKALTLVRSVLTRRRQAVQDL-RQQLAGCQEAVNLLQQ 421
Query: 999 QSPDYTEQYINEINKLNALLKQKDE---EIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
Q + E+ +L L ++D + + L ++++ ++ +L Q
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE-RELLQKAREELRQQLE 480
Query: 1056 KLENMEEEMQRVSKQLL---DSKQ-----HNEELQILVREQDDQIKELKETKLTFEMNIP 1107
LE ++RV+ +L DS Q EEL + VRE++ L+E + E
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE----RLQEMLMGLEAK-- 534
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
++E + T+ + + ++ + E+ I E L L TE
Sbjct: 535 QSESLSELITLREALESIH-LEGELLRQEQTEVTAALARAEQSIAE---LSSSENTLKTE 590
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+ + ++L LN L +++ +NQ +LE+ N + + + R+++
Sbjct: 591 VADLRAAAVKLSALNEALA----LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEH---ELRVQLSAFESKYEQLLDSVQSSTQEETN 1284
+ + LW+++ EA QK E EL+ L + + E++ + S ++
Sbjct: 647 LAEAEKRREALWEKN-THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQ--IEILRSEIEDEK---VAFXXXXX 1339
+EQ+ Q + +E R +QEK A V + +E+ +E ++ A
Sbjct: 706 ATTQLEQLH--QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAAQLQGLS 763
Query: 1340 XXXXXXXXXXXDLRTEN------QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXX 1393
+ + +N Q ++Q Q++ E +
Sbjct: 764 SAKELLESSLFEAQQQNSVIDEPQGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 1394 RVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENV--RQQL------VEYE 1445
+ DA A+ L Q E + HE + + E E +Q+L +E E
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 1446 K-RIEDLTYEKESELAILRLKMHENANHYET----MQKESEIERVKLIEELNVKITESVS 1500
K +E E+++E+ ++ + E E+ MQ E+E ERV L+E L E
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 1501 LNKQVAELNKALEEEVAKTNEMQTALENQ 1529
++Q+ L + ++ + K E L+ Q
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQ 972
>AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250kDa
protein.
Length = 2442
Score = 106 bits (254), Expect = 8e-22
Identities = 268/1517 (17%), Positives = 618/1517 (40%), Gaps = 124/1517 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
THL +++ + A + LQ ++ ++ ++Q+K++E EA
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 205 XXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEA---NK 258
++ + ++ ++ A+E + +D ++L +K++ SSL EA N
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 259 LLEAAR--FEISLEHSKLAQELEQXXXX-XXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS 315
++E + E+ ++ A+E+ Q A+Q + + + + E++G
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 316 LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKS 374
+ +K ++ Q ++ E + + E +KA+ S ++ L R
Sbjct: 842 TALEQQKAAHEK---------EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892
Query: 375 GRNT---ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEK 431
+ T A + + + +E+ + K ++ LE ++Q+ K+L D + E+
Sbjct: 893 EQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT-QKELADASQQL-ER 950
Query: 432 DTXXXXXXXXXXGKDTLIAQLQL-EHQQHMEGPSLIH---VGTNTEDVNEIAKVQEQLKQ 487
+ T I Q QL E Q+ ++ + H + E+ + + + + L++
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK 1010
Query: 488 ELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
++ D + +D ++L E ++ + E + K + + K++ L L + ++ +
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 547 FSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM 605
+ S +E+ L +++ + EL + L+ + + ++ + + + +E
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 606 ENLAETRLKA-ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
++ E +L+A + E++ L L + + + + + +Q Q+ + + S L
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA-L 1189
Query: 665 EEQIDALSASKKEL------ALVIENLKLDKEQLYGTIKD---LENDKEDIMNKLQNYIQ 715
++ + ++ S+ EL A + L+ D+ K L + + + +
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 716 ENMDLTDKLEKMSAEKISELLAKIN--HEEQSKIQTQF-GIDAKIQERDLYIENIESELS 772
+++ T + + +++ +L ++ E+S++ T+ + ++ + E + +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
Query: 773 KYKSRICRLEESIAVMEDR--RYSLERKADQ----LGSYLQEKQKAYSEY---TIQEDEL 823
+S + L E++A ++ R R L+R Q L +E A E+ + E
Sbjct: 1310 SLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA 1369
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
A +++ D + L++++E E +++ L+E L+++ Q AL+ +
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQT 1429
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
E E+ + Q Q + + +++ E +L ++K+ + DL+ E ++E
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDY 1003
+ L ++ + +T Q++E + + E NV E + LE D+ ++ Q+ Q D
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRET-QRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENM 1060
+Q + L L + +E + K+ Q + E++ L T LE
Sbjct: 1549 KKQLVT----LECLALELEEN----HHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIK-------ELKETK--LTFEMNIPKTEG 1111
+E+Q S Q+ D + H+ L ++E+D ++K EL+ K LT ++ E
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
M+ I+ + D + E +R ++QE++ + +
Sbjct: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ ++ + + QE I++L+ +QL + L V E S + QR
Sbjct: 1721 RGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE----TSLLLSQR 1776
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFE---SKYEQLLDSVQSSTQE-ETNKIV 1287
EI L +Q L + + E L+ QL + ++ +Q L+++Q Q+ + +
Sbjct: 1777 EQEIVVL-QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 1288 TMEQVTSLQ--------------NKLQDKEEHLRNLQEKYADVINQIEI-------LRSE 1326
E+ +LQ +LQD +E R L+E+ A +++ LR+E
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
Query: 1327 IEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
+++ A + R S+ +Q Q++L ++ + ++
Sbjct: 1896 SREQEKALLALQQQCAEQAQEHEVETRALQDSW--LQAQAVLKERDQELEALRAESQSSR 1953
Query: 1387 XXXXXXXRVNDAEAKVLELTH-QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYE 1445
+A + L H L+ K+ + ++ E + +L + +
Sbjct: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQA-ELSRSLEASTATLQASLDACQAHS 2012
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYE--TMQKESEI----ERVKLIEE-LNVKITES 1498
+++E+ +E E+ L+ E+ + Q++ E+ ER +L+E+ L ++ E+
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 1499 VSLNKQVAELNKALEEEVAK-----TNEMQTALENQEIEIVTLND--EITNLQNMVRASS 1551
+ KQ L + EEE + E+Q L +E EI+ L + + NL+ + +
Sbjct: 2073 MIQEKQ--NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 1552 SKIQKHVSFASDTKQGR 1568
+ + S D+ + R
Sbjct: 2131 TSPMEEQSLKLDSLEPR 2147
Score = 104 bits (249), Expect = 3e-21
Identities = 178/868 (20%), Positives = 377/868 (43%), Gaps = 67/868 (7%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++L ++ +++ QL + D + + L Q QK +++ K+ + +E V
Sbjct: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
Query: 559 RLTEELH-HLSQKVAEL----EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL 613
+ E H L + A L +EEK +LQ + D + E D + EN E
Sbjct: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
Query: 614 KAISLLESQKFDLVQEL--HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDAL 671
S + Q D L +L ++ V+D ++ Q + + EE+ AL
Sbjct: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
++L + L L G + L ++E ++ K + +++ +++ ++ E +
Sbjct: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE-LLQKAREELRQQLEVLEQ-EAWRLRR 491
Query: 732 IS-ELLAKINHEEQSKIQTQFGIDAKIQERDLYIE---NIESELSKYKSRICRLEESIAV 787
++ EL + + + K + Q + ++ER+ E +E++ S+ S + L E++
Sbjct: 492 VNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALES 551
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL-------------MDHD 834
L ++ ++ + L +++ +E + E+ L +A L + D
Sbjct: 552 SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD 611
Query: 835 RV-VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+V + +QLL++E EN+ + + + + LQ+ L++ ++ AL EK T L E++
Sbjct: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK--NTHL-EAQL 668
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
K + +L+++L+ I E K+EI+ E Q E+A + L+++ ++
Sbjct: 669 QKAEEAGAELQADLRDIQEE--------KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
E + + + + L + ++ + + +L ++ + + + + E + E +
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQ--LQGLSSAKELLESSLFEAQQ 778
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
N++++ ++ Q + A+ V + +L T+ E+E ++QL
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL---DTERSQAEQERDAAARQLAQ 835
Query: 1074 SKQHNE-ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
++Q + L+ + ++ +L+E K E + + E ++ +E + + ++
Sbjct: 836 AEQEGKTALEQQKAAHEKEVNQLRE-KWEKERSWHQQE---LAKALESLEREKMELEMRL 891
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTGHDVV 1191
++ Q EEE Q S L + +L TE + ++ LET L T+ D
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQM--QLETEKE----RVSLLETLLQTQKELADAS 945
Query: 1192 NQEQINQLKSKLEQL-NTENDNLLST-VAELRSSISSAVDQRGFEIAELWKQ--HLAQRE 1247
Q + + K+++L E +L T + E + + A Q ++A L ++ L Q +
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE--ETNKI--VTMEQVTSLQNKLQDKE 1303
D QK +L+ QL A + + VQ +E E N+I + SL L +KE
Sbjct: 1006 MDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKE 1065
Query: 1304 EHLRNLQEKYADVINQIEI--LRSEIED 1329
+ L LQE AD I Q E+ LR ++++
Sbjct: 1066 QRLLVLQE--ADSIRQQELSALRQDMQE 1091
Score = 101 bits (241), Expect = 3e-20
Identities = 277/1469 (18%), Positives = 579/1469 (39%), Gaps = 158/1469 (10%)
Query: 212 EDTKQQMTKMQE--NFIAMEAE-WKDE----KQRLLKDIESKDV----------RISSLE 254
+D +QQ+ QE N + + + W++E +QRL K +D + SL
Sbjct: 403 QDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLS 462
Query: 255 EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
+ +LL+ AR E+ + L QE + Q E E + E+
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE 522
Query: 315 SLEIANMTELTKKIELLEHLNCQIRQT--NKELENKLATMGTESKAVSSPSKKGSPLISR 372
L+ M K+ E L L +R+ + LE +L +++ ++ ++ +
Sbjct: 523 RLQEMLMGLEAKQSESLSEL-ITLREALESSHLEGELLRQ-EQTEVTAALARAEQSIAEL 580
Query: 373 KSGRNT----ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
S NT + +++ +LS+ DK ++ +LE QS+ + E
Sbjct: 581 SSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQAR 640
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ L+ + Q+ E + + D+ +I + +E+++++
Sbjct: 641 NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA-----DLRDIQEEKEEIQKK 695
Query: 489 LND-----EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
L++ E ++ L ++ K EE + + E +A + ++ + + Q
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI--------- 594
+ +S S KE+ L L Q+ + +E KG L++ + + +
Sbjct: 756 AEQLQGLS-SAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 595 -ESDVYKKMIEMEN------LAETRLKAISLLESQKFDLVQELHILQQKYDEV----EDK 643
E D + E E LA+ + + LE QK +E++ L++K+++ + +
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE 872
Query: 644 LAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKE------LALVIENLKLDKEQ--LYG 694
LA + L+ +++ E++ + +++A+ A ++E AL L+ +KE+ L
Sbjct: 873 LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLE 932
Query: 695 TIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
T+ + + D +L+ ++++M + KL++ I + + E + Q D
Sbjct: 933 TLLQTQKELADASQQLER-LRQDMKV-QKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 755 -AKIQERDLYIENIESELSKY----KSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
A +QE + + +L K KS++ ++S ++E R+ + +E
Sbjct: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL 1050
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL-------EIEHENKELQKKNQILLEEN 862
++ + T+ E RL VL + D + +++L E + E KEL + ++L +E
Sbjct: 1051 EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV 1110
Query: 863 QNLQISL----SDMQQHYNA--LVEKANRTDL--AESESTKYQTQLRDLESNLKRITHEH 914
+ + + + + A + E+ R L E+++ + Q +LR ES L+ + E
Sbjct: 1111 KEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ 1170
Query: 915 QT-LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
Q Q + ++ L + S + L+ + + V LE +N +
Sbjct: 1171 QPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-SAPSVWGLEPD----QNGARS 1225
Query: 974 LNMNVEELNKMNLELIDKHVQK--QQTQSPDYTEQYI-NEINKLNALLKQKDEEIIALNQ 1030
L L ++ E + + K Q T + +++ KL L + E ++
Sbjct: 1226 LFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL--LDSKQHNEELQILVREQ 1088
++ + Q +S + + +++ K ++E E+ + + + L S+ ELQ + +
Sbjct: 1286 ELQDLQ----RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE 1148
+ ++ + + LT + + + ++ + + + D +V+ E
Sbjct: 1342 ERELLQAAKENLTAQ--VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER 1399
Query: 1149 E---FIQERS--------VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
E +QE+ LQE A L L E ++ L EL + + +
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE 1459
Query: 1198 QLKSKLEQLNTENDNLLSTVAELRSSIS------SAVDQRGFEIAELWKQHLAQREADFQ 1251
L L++ N E D + EL S AV +R ++ + ++ + + E D +
Sbjct: 1460 LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT-VQREQIRELEKDRE 1518
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
+ L QL E K +Q+++S + Q+ ++VT+E L +L++ H Q+
Sbjct: 1519 TQRNVLEHQLLELEKK-DQMIESQRGQVQDLKKQLVTLE---CLALELEENH-HKMECQQ 1573
Query: 1312 KYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN 1371
K I+ L + E ++VA DL +Q Q Q I ++
Sbjct: 1574 KL------IKELEGQRETQRVALTHLTL-----------DLEERSQEL-QAQSSQIHDLE 1615
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN 1431
+ L + ++ + + + LT LE +D E+ + + QR
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 1432 DEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK--ESEIERVKLIE 1489
+ + + + L + + + E+ EL R M E A + K +E +KLI
Sbjct: 1676 RQTKILEEDLEQIKLSLR----ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 1490 ELNVKITESVSLN-KQVAELNKALEEEVA----KTNEMQTALENQEIEIVTLNDEITNLQ 1544
K E + ++ EL LE+++ K E L +E EIV L ++ +
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791
Query: 1545 NMVRASSSKIQKHVSFASDTKQGRDEQLD 1573
+Q + A RD++L+
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELE 1820
Score = 81.8 bits (193), Expect = 2e-14
Identities = 144/785 (18%), Positives = 336/785 (42%), Gaps = 60/785 (7%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E + E+ K +E + L ++ ++ KD + ++S Q+ L ++ ++++ N
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKD--QMIESQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
H K++ QK I ++ + V LT L ++ EL+ + Q+H D +S
Sbjct: 1566 HH-KMECQQKLIKELEGQRETQR--VALTHLTLDLEERSQELQAQSS--QIH--DLESHS 1618
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH------ILQQKYDEV-EDKLA 645
+ + +++ E + +++ + I L+ QK L Q+L +LQ++ +V ED+
Sbjct: 1619 TV---LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE---ND 702
+++ + + +IK + L E+ L+ ++ + E K + G+++ ++ D
Sbjct: 1676 RQTKILEEDL-EQIK-LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSA---EKISELLAKINHEEQSKIQTQFGIDAKIQE 759
KE + Q +I E +L D+LE+ K+ E ++ EQ + Q + ++
Sbjct: 1734 KEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQ 1793
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
+L ++++S+L + + + + ++ + ++ + + + +++ Q A + +
Sbjct: 1794 GELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMT 1853
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL----LEENQNLQISLSDMQQH 875
L R L DH + E+ E + +Q ++L E + + L+ QQ
Sbjct: 1854 ---LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC 1910
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
E T + + Q L++ + L+ + E Q+ Q++ E
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA----- 1965
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQK 995
++ A+ + E+++ +L L+ ++ +++ + + LE + ++
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ-ASLDACQAHSRQLE---EALRI 2021
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
Q+ + D +Y ++ +L L Q+DEE L + Q+ S+ + + Q
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEE---LRHQQEREQLLEKSLAQRVQENMIQ--- 2075
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
+ +N+ +E R +++ Q ELQ+ + +++ +I EL+ET+ + N E + S
Sbjct: 2076 EKQNLGQE--REEEEIRGLHQSVRELQLTLAQKEQEILELRETQ---QRN--NLEALPHS 2128
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI 1175
PM + + +D L+ + +E +E++ L L + +
Sbjct: 2129 HKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE-WREKAQDLALSLAQTKASV 2187
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLE--QLNTENDNLLSTVAELRSSISSAVDQRGF 1233
L+ + L + + +L+ +LE + E + L S A + + S +Q G
Sbjct: 2188 SSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ-GV 2246
Query: 1234 EIAEL 1238
++ E+
Sbjct: 2247 QLGEV 2251
Score = 63.7 bits (148), Expect = 5e-09
Identities = 191/997 (19%), Positives = 404/997 (40%), Gaps = 112/997 (11%)
Query: 151 IKEKD--NALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXX 208
I E+D A S L++K + +E+ + + + E+ ++ A+ KA
Sbjct: 1376 ILEEDLRTARSALKLKNEEVESE-RERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 209 XXXEDTK---QQMTKMQE-NFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + Q++ K +E A+E D K+R ++++ + +I LE+ +LE
Sbjct: 1435 EEVETLRGQIQELEKQREMQKAALELLSLDLKKRN-QEVDLQQEQIQELEKCRSVLEHLP 1493
Query: 265 FEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE-----IA 319
+ KL + EQ L Q +E +++ ++G ++ +
Sbjct: 1494 MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553
Query: 320 NMTELTKKIELLEH-LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
+ L ++E H + CQ ++ KELE + T ++ ++ S + +S +
Sbjct: 1554 TLECLALELEENHHKMECQ-QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-- 1610
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDL--------VDKEYV--- 427
++S + L+ E +D + K + +I +L+ + L +DL + KE +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 428 ---------ISEKDTXXXXXXXXXXGKD-TLIAQLQLEHQQHMEGPS------LIHVGTN 471
I E+D G++ T QL E + +GPS L H+
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 472 TEDVN-EIAKVQEQLK--QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
D E+ QE + QEL D+++ ++ L K+ ++Q EI + + +
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQ-QLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY 588
+ +LK + +Q +D ++ + + + +EL L Q+ + + ++ ++
Sbjct: 1790 AREQGELKEQSLQSQLD------EAQRALAQRDQELEALQQEQQQAQGQEERVKE----- 1838
Query: 589 DSGRMIESDVYKKMIEMENLA-ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
++D + +E ++ + R + + Q L +EL + ++ +E+ L D+
Sbjct: 1839 ------KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+Q E + L++Q A A + E +E L L E D+E +
Sbjct: 1893 RAESREQ---EKALLALQQQC-AEQAQEHE----VETRALQDSWLQAQAVLKERDQE--L 1942
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
L+ Q + ++ + AE + E L K + Q K Q + + +
Sbjct: 1943 EALRAESQSSRH-QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 768 ESELSKYKSRICRLEESIAVME----DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
++ L ++ +LEE++ + E D+ + QL L ++ + +E L
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
LA + + + EKQ L E E +E++ +Q + E LQ++L+ +Q L E
Sbjct: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE----LQLTLAQKEQEILELRETQ 2117
Query: 884 NRTDLA----ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
R +L +++ + Q L+S R+ E + L + + E EIE+ + +
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR-QTEAREIEWREKAQDL 2176
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
E L+A + E + + L +EL EL + ++K++
Sbjct: 2177 ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ---DEL-----ELTRRALEKERLH 2228
Query: 1000 SPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
SP T A L + E+ + L + ++ + + +S + +LE+
Sbjct: 2229 SPGATS---------TAELGSRGEQGVQLGE-VSGVEAEPSPDGMEKQS----WRQRLEH 2274
Query: 1060 MEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+++ + R+ ++HN +L+ + + + + ++LK
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Score = 61.3 bits (142), Expect = 3e-08
Identities = 131/709 (18%), Positives = 275/709 (38%), Gaps = 32/709 (4%)
Query: 834 DRVVEKQLL--EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
DRV E L + + +N++ +K + L E + L+ + +++ +H +L A L+
Sbjct: 283 DRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQ 342
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ K TQ+ E + H+ + + + + + +R VL + +
Sbjct: 343 QVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRS--VLTRRRQ 400
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT---QSPDYTEQYI 1008
++ + Q A QE N ++ + EE K + + K ++ T Q+ D + +
Sbjct: 401 A-VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGE-V 458
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
+ ++K LL++ EE+ + + Q ++ + E +L Q + EE+ + +
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLE--QEAWRLRRVNVELQL-QGDSAQGQKEEQQEELH 515
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV 1128
+ + ++ E L L +Q + + EL + E + EG ++ ++
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESS--HLEGELLRQEQTEVTAALARA 573
Query: 1129 DXXXXXXXXXXXXLK--VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
+ LK V + + S L E A L + +++QLE N +
Sbjct: 574 EQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQ---QLLQLEEENQSVC 630
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI-AELWKQHLAQ 1245
++ N L+ L + + L L + + A ++ G E+ A+L + + +
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA-EEAGAELQADL--RDIQE 687
Query: 1246 READFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEH 1305
+ + QK E R Q A ++ EQL ++ QEE E+ ++ K E
Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQ--EAKRQEEVLARAVQEKEALVREKAA-LEVR 744
Query: 1306 LRNLQEKYADVINQIEILRSEIED-EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQE 1364
L+ ++ D+ Q++ L S E E F +++ + + +
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 1365 QSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
Q + + ++S + E K L Q + E+ Q ++
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA-LEQQKAAHEKEVNQLREKWE 863
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYET----MQKES 1480
+ E + L + +E E+++E+ ++ + E E+ MQ E+
Sbjct: 864 KERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
E ERV L+E L E ++Q+ L + ++ + K E L+ Q
Sbjct: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQ 972
Score = 37.9 bits (84), Expect = 0.30
Identities = 110/620 (17%), Positives = 235/620 (37%), Gaps = 35/620 (5%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVT---QLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
N+Q E+ R ++ + K ++Y + +LE +L+ I NVEE N L L+
Sbjct: 44 NSQ-EAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDEL-LV 101
Query: 990 DKHVQKQQTQS-PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
++Q+ +S + Q + K + + K E++ L + A+ M S ++
Sbjct: 102 RLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQM 161
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
+ F L+ + + ++++ ++H E++ D + ELK + ++
Sbjct: 162 EQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK---SATDRDLMELKAEHVRLSGSLLT 218
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQERS-VLQEQSAKLN 1165
+ T+ S + N L K QE E+ ERS L + ++ +
Sbjct: 219 ---CCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGD 275
Query: 1166 TELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSIS 1225
E E ++ +L L T+ + ++ I L+ +E L T + L+ A L +
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK 1285
I ++ + + + + Q + HE ++L + D+ ++ T +
Sbjct: 336 EEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVL 395
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI-----EDEKVAFXXXXXX 1340
+ V L+ +L +E + LQ+++ + + LR + E + +A
Sbjct: 396 TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 1341 XXXXXXXXXXDL----RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+L R E + ++ EQ + N +L+ ++
Sbjct: 456 GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
Query: 1397 DA---EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTY 1453
A ++ E+ LE K SE + L + E E +RQ+ E +
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAAL----- 570
Query: 1454 EKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALE 1513
+E +I L EN E + ++ + E + V LN+Q+ +L + +
Sbjct: 571 -ARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE--ALALDKVGLNQQLLQLEEENQ 627
Query: 1514 EEVAKTNEMQTALENQEIEI 1533
++ + A ++++
Sbjct: 628 SVCSRMEAAEQARNALQVDL 647
>AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associated
protein 1 protein.
Length = 2442
Score = 106 bits (254), Expect = 8e-22
Identities = 268/1517 (17%), Positives = 618/1517 (40%), Gaps = 124/1517 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
THL +++ + A + LQ ++ ++ ++Q+K++E EA
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 205 XXXXXXXEDTK---QQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEA---NK 258
++ + ++ ++ A+E + +D ++L +K++ SSL EA N
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 259 LLEAAR--FEISLEHSKLAQELEQXXXX-XXXXXXXXXXLAKQSIEPSCEEKTEIEEKGS 315
++E + E+ ++ A+E+ Q A+Q + + + + E++G
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 316 LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTE-SKAVSSPSKKGSPLISRKS 374
+ +K ++ Q ++ E + + E +KA+ S ++ L R
Sbjct: 842 TALEQQKAAHEK---------EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892
Query: 375 GRNT---ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEK 431
+ T A + + + +E+ + K ++ LE ++Q+ K+L D + E+
Sbjct: 893 EQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT-QKELADASQQL-ER 950
Query: 432 DTXXXXXXXXXXGKDTLIAQLQL-EHQQHMEGPSLIH---VGTNTEDVNEIAKVQEQLKQ 487
+ T I Q QL E Q+ ++ + H + E+ + + + + L++
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK 1010
Query: 488 ELNDEIKDVNVKDLIEKLKSAE-EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDN 546
++ D + +D ++L E ++ + E + K + + K++ L L + ++ +
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 547 FSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM 605
+ S +E+ L +++ + EL + L+ + + ++ + + + +E
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 606 ENLAETRLKA-ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
++ E +L+A + E++ L L + + + + + +Q Q+ + + S L
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA-L 1189
Query: 665 EEQIDALSASKKEL------ALVIENLKLDKEQLYGTIKD---LENDKEDIMNKLQNYIQ 715
++ + ++ S+ EL A + L+ D+ K L + + + +
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 716 ENMDLTDKLEKMSAEKISELLAKIN--HEEQSKIQTQF-GIDAKIQERDLYIENIESELS 772
+++ T + + +++ +L ++ E+S++ T+ + ++ + E + +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
Query: 773 KYKSRICRLEESIAVMEDR--RYSLERKADQ----LGSYLQEKQKAYSEY---TIQEDEL 823
+S + L E++A ++ R R L+R Q L +E A E+ + E
Sbjct: 1310 SLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA 1369
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
A +++ D + L++++E E +++ L+E L+++ Q AL+ +
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQT 1429
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
E E+ + Q Q + + +++ E +L ++K+ + DL+ E ++E
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDY 1003
+ L ++ + +T Q++E + + E NV E + LE D+ ++ Q+ Q D
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRET-QRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENM 1060
+Q + L L + +E + K+ Q + E++ L T LE
Sbjct: 1549 KKQLVT----LECLALELEEN----HHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIK-------ELKETK--LTFEMNIPKTEG 1111
+E+Q S Q+ D + H+ L ++E+D ++K EL+ K LT ++ E
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
M+ I+ + D + E +R ++QE++ + +
Sbjct: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ ++ + + QE I++L+ +QL + L V E S + QR
Sbjct: 1721 RGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE----TSLLLSQR 1776
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFE---SKYEQLLDSVQSSTQE-ETNKIV 1287
EI L +Q L + + E L+ QL + ++ +Q L+++Q Q+ + +
Sbjct: 1777 EQEIVVL-QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 1288 TMEQVTSLQ--------------NKLQDKEEHLRNLQEKYADVINQIEI-------LRSE 1326
E+ +LQ +LQD +E R L+E+ A +++ LR+E
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
Query: 1327 IEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXX 1386
+++ A + R S+ +Q Q++L ++ + ++
Sbjct: 1896 SREQEKALLALQQQCAEQAQEHEVETRALQDSW--LQAQAVLKERDQELEALRAESQSSR 1953
Query: 1387 XXXXXXXRVNDAEAKVLELTH-QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYE 1445
+A + L H L+ K+ + ++ E + +L + +
Sbjct: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQA-ELSRSLEASTATLQASLDACQAHS 2012
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYE--TMQKESEI----ERVKLIEE-LNVKITES 1498
+++E+ +E E+ L+ E+ + Q++ E+ ER +L+E+ L ++ E+
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 1499 VSLNKQVAELNKALEEEVAK-----TNEMQTALENQEIEIVTLND--EITNLQNMVRASS 1551
+ KQ L + EEE + E+Q L +E EI+ L + + NL+ + +
Sbjct: 2073 MIQEKQ--NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
Query: 1552 SKIQKHVSFASDTKQGR 1568
+ + S D+ + R
Sbjct: 2131 TSPMEEQSLKLDSLEPR 2147
Score = 103 bits (248), Expect = 4e-21
Identities = 174/895 (19%), Positives = 395/895 (44%), Gaps = 71/895 (7%)
Query: 461 EGPSLIHVGTNTEDVNEIA--KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDE 518
E L+ + T+++ + A + QE ++ + +++ ++D + +L + Q + N++
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
Query: 519 ----IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAE 573
I A + + +++NH ++ N + S +++++ +T+ + +A+
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 574 LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHIL 633
+ +L+L + ++D K + + ++ R +A+ L Q + +++L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDAD--KALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLL 419
Query: 634 QQKYDEVEDKLADISQ----LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
QQ++D+ E++ + Q L ++ ++V L+ ++D+LS ++ L E L+
Sbjct: 420 QQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQL 479
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM--SAEKISELLAKINHEEQSKI 747
E L L ++ + + + D ++L E++ E+L + ++ +
Sbjct: 480 EVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERERLQEMLMGLEAKQSESL 539
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+ ++ L E + E ++ + + R E+SIA + +L+ + L +
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA-- 597
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQ 866
++ L LA+ D+V + +QLL++E EN+ + + + + LQ
Sbjct: 598 ---------AVKLSALNEALAL----DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ 644
Query: 867 ISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE 926
+ L++ ++ AL EK T L E++ K + +L+++L+ I E K+EI+
Sbjct: 645 VDLAEAEKRREALWEK--NTHL-EAQLQKAEEAGAELQADLRDIQEE--------KEEIQ 693
Query: 927 DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
E Q E+A + L+++ ++ E + + + + L + ++ + +
Sbjct: 694 KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+L ++ + + + + E + E + N++++ ++ Q + A+ V
Sbjct: 754 DLAEQ--LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL 811
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE-ELQILVREQDDQIKELKETKLTFEMN 1105
+ +L T+ E+E ++QL ++Q + L+ + ++ +L+E K E +
Sbjct: 812 KLEL---DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE-KWEKERS 867
Query: 1106 IPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN 1165
+ E ++ +E + + ++ ++ Q EEE Q S L + +L
Sbjct: 868 WHQQE---LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM--QLE 922
Query: 1166 TELQECYTKIIQLET-LNTELTGHDVVNQEQINQLKSKLEQL-NTENDNLLST-VAELRS 1222
TE + ++ LET L T+ D Q + + K+++L E +L T + E +
Sbjct: 923 TEKE----RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 1223 SISSAVDQRGFEIAELWKQ--HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
+ A Q ++A L ++ L Q + D QK +L+ QL A + + VQ +
Sbjct: 979 ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLR 1038
Query: 1281 E--ETNKI--VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI--LRSEIED 1329
E E N+I + SL L +KE+ L LQE AD I Q E+ LR ++++
Sbjct: 1039 ETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE--ADSIRQQELSALRQDMQE 1091
Score = 99 bits (238), Expect = 7e-20
Identities = 276/1469 (18%), Positives = 579/1469 (39%), Gaps = 158/1469 (10%)
Query: 212 EDTKQQMTKMQE--NFIAMEAE-WKDE----KQRLLKDIESKDV----------RISSLE 254
+D +QQ+ QE N + + + W++E +QRL K +D + SL
Sbjct: 403 QDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLS 462
Query: 255 EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
+ +LL+ AR E+ + L QE + Q + E + E+
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERE 522
Query: 315 SLEIANMTELTKKIELLEHLNCQIRQT--NKELENKLATMGTESKAVSSPSKKGSPLISR 372
L+ M K+ E L L +R+ + LE +L +++ ++ ++ +
Sbjct: 523 RLQEMLMGLEAKQSESLSEL-ITLREALESSHLEGELLRQ-EQTEVTAALARAEQSIAEL 580
Query: 373 KSGRNT----ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
S NT + +++ +LS+ DK ++ +LE QS+ + E
Sbjct: 581 SSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQAR 640
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
+ L+ + Q+ E + + D+ +I + +E+++++
Sbjct: 641 NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA-----DLRDIQEEKEEIQKK 695
Query: 489 LND-----EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
L++ E ++ L ++ K EE + + E +A + ++ + + Q
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI--------- 594
+ +S S KE+ L L Q+ + +E KG L++ + + +
Sbjct: 756 AEQLQGLS-SAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 595 -ESDVYKKMIEMEN------LAETRLKAISLLESQKFDLVQELHILQQKYDEV----EDK 643
E D + E E LA+ + + LE QK +E++ L++K+++ + +
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE 872
Query: 644 LAD-ISQLQSDQVCSEIKSVHLEEQIDALSASKKE------LALVIENLKLDKEQ--LYG 694
LA + L+ +++ E++ + +++A+ A ++E AL L+ +KE+ L
Sbjct: 873 LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLE 932
Query: 695 TIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
T+ + + D +L+ ++++M + KL++ I + + E + Q D
Sbjct: 933 TLLQTQKELADASQQLER-LRQDMKV-QKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 755 -AKIQERDLYIENIESELSKY----KSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
A +QE + + +L K KS++ ++S ++E R+ + +E
Sbjct: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL 1050
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL-------EIEHENKELQKKNQILLEEN 862
++ + T+ E RL VL + D + +++L E + E KEL + ++L +E
Sbjct: 1051 EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV 1110
Query: 863 QNLQISL----SDMQQHYNA--LVEKANRTDL--AESESTKYQTQLRDLESNLKRITHEH 914
+ + + + + A + E+ R L E+++ + Q +LR ES L+ + E
Sbjct: 1111 KEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ 1170
Query: 915 QT-LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
Q Q + ++ L + S + L+ + + V LE +N +
Sbjct: 1171 QPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-SAPSVWGLEPD----QNGARS 1225
Query: 974 LNMNVEELNKMNLELIDKHVQK--QQTQSPDYTEQYI-NEINKLNALLKQKDEEIIALNQ 1030
L L ++ E + + K Q T + +++ KL L + E ++
Sbjct: 1226 LFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL--LDSKQHNEELQILVREQ 1088
++ + Q +S + + +++ K ++E E+ + + + L S+ ELQ + +
Sbjct: 1286 ELQDLQ----RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE 1148
+ ++ + + LT + + + ++ + + + D +V+ E
Sbjct: 1342 ERELLQAAKENLTAQ--VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER 1399
Query: 1149 E---FIQERS--------VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
E +QE+ LQE A L L E ++ L EL + + +
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE 1459
Query: 1198 QLKSKLEQLNTENDNLLSTVAELRSSIS------SAVDQRGFEIAELWKQHLAQREADFQ 1251
L L++ N E D + EL S AV +R ++ + ++ + + E D +
Sbjct: 1460 LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT-VQREQIRELEKDRE 1518
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
+ L QL E K +Q+++S + Q+ ++VT+E L +L++ H Q+
Sbjct: 1519 TQRNVLEHQLLELEKK-DQMIESQRGQVQDLKKQLVTLE---CLALELEENH-HKMECQQ 1573
Query: 1312 KYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN 1371
K I+ L + E ++VA DL +Q Q Q I ++
Sbjct: 1574 KL------IKELEGQRETQRVALTHLTL-----------DLEERSQEL-QAQSSQIHDLE 1615
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN 1431
+ L + ++ + + + LT LE +D E+ + + QR
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 1432 DEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK--ESEIERVKLIE 1489
+ + + + L + + + E+ EL R M E A + K +E +KLI
Sbjct: 1676 RQTKILEEDLEQIKLSLR----ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 1490 ELNVKITESVSLN-KQVAELNKALEEEVA----KTNEMQTALENQEIEIVTLNDEITNLQ 1544
K E + ++ EL LE+++ K E L +E EIV L ++ +
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791
Query: 1545 NMVRASSSKIQKHVSFASDTKQGRDEQLD 1573
+Q + A RD++L+
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELE 1820
Score = 81.8 bits (193), Expect = 2e-14
Identities = 144/785 (18%), Positives = 336/785 (42%), Gaps = 60/785 (7%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E + E+ K +E + L ++ ++ KD + ++S Q+ L ++ ++++ N
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKD--QMIESQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
H K++ QK I ++ + V LT L ++ EL+ + Q+H D +S
Sbjct: 1566 HH-KMECQQKLIKELEGQRETQR--VALTHLTLDLEERSQELQAQSS--QIH--DLESHS 1618
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH------ILQQKYDEV-EDKLA 645
+ + +++ E + +++ + I L+ QK L Q+L +LQ++ +V ED+
Sbjct: 1619 TV---LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE---ND 702
+++ + + +IK + L E+ L+ ++ + E K + G+++ ++ D
Sbjct: 1676 RQTKILEEDL-EQIK-LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSA---EKISELLAKINHEEQSKIQTQFGIDAKIQE 759
KE + Q +I E +L D+LE+ K+ E ++ EQ + Q + ++
Sbjct: 1734 KEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQ 1793
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
+L ++++S+L + + + + ++ + ++ + + + +++ Q A + +
Sbjct: 1794 GELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMT 1853
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL----LEENQNLQISLSDMQQH 875
L R L DH + E+ E + +Q ++L E + + L+ QQ
Sbjct: 1854 ---LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC 1910
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
E T + + Q L++ + L+ + E Q+ Q++ E
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA----- 1965
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQK 995
++ A+ + E+++ +L L+ ++ +++ + + LE + ++
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ-ASLDACQAHSRQLE---EALRI 2021
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
Q+ + D +Y ++ +L L Q+DEE L + Q+ S+ + + Q
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEE---LRHQQEREQLLEKSLAQRVQENMIQ--- 2075
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
+ +N+ +E R +++ Q ELQ+ + +++ +I EL+ET+ + N E + S
Sbjct: 2076 EKQNLGQE--REEEEIRGLHQSVRELQLTLAQKEQEILELRETQ---QRN--NLEALPHS 2128
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI 1175
PM + + +D L+ + +E +E++ L L + +
Sbjct: 2129 HKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE-WREKAQDLALSLAQTKASV 2187
Query: 1176 IQLETLNTELTGHDVVNQEQINQLKSKLE--QLNTENDNLLSTVAELRSSISSAVDQRGF 1233
L+ + L + + +L+ +LE + E + L S A + + S +Q G
Sbjct: 2188 SSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ-GV 2246
Query: 1234 EIAEL 1238
++ E+
Sbjct: 2247 QLGEV 2251
Score = 63.7 bits (148), Expect = 5e-09
Identities = 191/997 (19%), Positives = 404/997 (40%), Gaps = 112/997 (11%)
Query: 151 IKEKD--NALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXX 208
I E+D A S L++K + +E+ + + + E+ ++ A+ KA
Sbjct: 1376 ILEEDLRTARSALKLKNEEVESE-RERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 209 XXXEDTK---QQMTKMQE-NFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + Q++ K +E A+E D K+R ++++ + +I LE+ +LE
Sbjct: 1435 EEVETLRGQIQELEKQREMQKAALELLSLDLKKRN-QEVDLQQEQIQELEKCRSVLEHLP 1493
Query: 265 FEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE-----IA 319
+ KL + EQ L Q +E +++ ++G ++ +
Sbjct: 1494 MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553
Query: 320 NMTELTKKIELLEH-LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
+ L ++E H + CQ ++ KELE + T ++ ++ S + +S +
Sbjct: 1554 TLECLALELEENHHKMECQ-QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-- 1610
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDL--------VDKEYV--- 427
++S + L+ E +D + K + +I +L+ + L +DL + KE +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 428 ---------ISEKDTXXXXXXXXXXGKD-TLIAQLQLEHQQHMEGPS------LIHVGTN 471
I E+D G++ T QL E + +GPS L H+
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 472 TEDVN-EIAKVQEQLK--QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
D E+ QE + QEL D+++ ++ L K+ ++Q EI + + +
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQ-QLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY 588
+ +LK + +Q +D ++ + + + +EL L Q+ + + ++ ++
Sbjct: 1790 AREQGELKEQSLQSQLD------EAQRALAQRDQELEALQQEQQQAQGQEERVKE----- 1838
Query: 589 DSGRMIESDVYKKMIEMENLA-ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
++D + +E ++ + R + + Q L +EL + ++ +E+ L D+
Sbjct: 1839 ------KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+Q E + L++Q A A + E +E L L E D+E +
Sbjct: 1893 RAESREQ---EKALLALQQQC-AEQAQEHE----VETRALQDSWLQAQAVLKERDQE--L 1942
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
L+ Q + ++ + AE + E L K + Q K Q + + +
Sbjct: 1943 EALRAESQSSRH-QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 768 ESELSKYKSRICRLEESIAVME----DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
++ L ++ +LEE++ + E D+ + QL L ++ + +E L
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
LA + + + EKQ L E E +E++ +Q + E LQ++L+ +Q L E
Sbjct: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE----LQLTLAQKEQEILELRETQ 2117
Query: 884 NRTDLA----ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
R +L +++ + Q L+S R+ E + L + + E EIE+ + +
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR-QTEAREIEWREKAQDL 2176
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
E L+A + E + + L +EL EL + ++K++
Sbjct: 2177 ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ---DEL-----ELTRRALEKERLH 2228
Query: 1000 SPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
SP T A L + E+ + L + ++ + + +S + +LE+
Sbjct: 2229 SPGATS---------TAELGSRGEQGVQLGE-VSGVEAEPSPDGMEKQS----WRQRLEH 2274
Query: 1060 MEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+++ + R+ ++HN +L+ + + + + ++LK
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Score = 60.1 bits (139), Expect = 6e-08
Identities = 130/709 (18%), Positives = 275/709 (38%), Gaps = 32/709 (4%)
Query: 834 DRVVEKQLL--EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
DRV E L + + +N++ +K + L E + L+ + +++ +H +L A L+
Sbjct: 283 DRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQ 342
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ K TQ+ E + H+ + + + + + +R VL + +
Sbjct: 343 QVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRS--VLTRRRQ 400
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT---QSPDYTEQYI 1008
++ + Q A QE N ++ + EE K + + K ++ T Q+ D + +
Sbjct: 401 A-VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGE-V 458
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
+ ++K LL++ EE+ + + Q ++ + E +L Q + E++ + +
Sbjct: 459 DSLSKERELLQKAREELRQQLEVLE--QEAWRLRRVNVELQL-QGDSAQGQKEDQQEELH 515
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV 1128
+ + ++ E L L +Q + + EL + E + EG ++ ++
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESS--HLEGELLRQEQTEVTAALARA 573
Query: 1129 DXXXXXXXXXXXXLK--VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
+ LK V + + S L E A L + +++QLE N +
Sbjct: 574 EQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQ---QLLQLEEENQSVC 630
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI-AELWKQHLAQ 1245
++ N L+ L + + L L + + A ++ G E+ A+L + + +
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA-EEAGAELQADL--RDIQE 687
Query: 1246 READFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEH 1305
+ + QK E R Q A ++ EQL ++ QEE E+ ++ K E
Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQ--EAKRQEEVLARAVQEKEALVREKAA-LEVR 744
Query: 1306 LRNLQEKYADVINQIEILRSEIED-EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQE 1364
L+ ++ D+ Q++ L S E E F +++ + + +
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 1365 QSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
Q + + ++S + E K L Q + E+ Q ++
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA-LEQQKAAHEKEVNQLREKWE 863
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYET----MQKES 1480
+ E + L + +E E+++E+ ++ + E E+ MQ E+
Sbjct: 864 KERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
E ERV L+E L E ++Q+ L + ++ + K E L+ Q
Sbjct: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQ 972
Score = 37.9 bits (84), Expect = 0.30
Identities = 110/620 (17%), Positives = 235/620 (37%), Gaps = 35/620 (5%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVT---QLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
N+Q E+ R ++ + K ++Y + +LE +L+ I NVEE N L L+
Sbjct: 44 NSQ-EAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDEL-LV 101
Query: 990 DKHVQKQQTQS-PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
++Q+ +S + Q + K + + K E++ L + A+ M S ++
Sbjct: 102 RLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQM 161
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
+ F L+ + + ++++ ++H E++ D + ELK + ++
Sbjct: 162 EQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK---SATDRDLMELKAEHVRLSGSLLT 218
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQERS-VLQEQSAKLN 1165
+ T+ S + N L K QE E+ ERS L + ++ +
Sbjct: 219 ---CCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGD 275
Query: 1166 TELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSIS 1225
E E ++ +L L T+ + ++ I L+ +E L T + L+ A L +
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK 1285
I ++ + + + + Q + HE ++L + D+ ++ T +
Sbjct: 336 EEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVL 395
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI-----EDEKVAFXXXXXX 1340
+ V L+ +L +E + LQ+++ + + LR + E + +A
Sbjct: 396 TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 1341 XXXXXXXXXXDL----RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+L R E + ++ EQ + N +L+ ++
Sbjct: 456 GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELH 515
Query: 1397 DA---EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTY 1453
A ++ E+ LE K SE + L + E E +RQ+ E +
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAAL----- 570
Query: 1454 EKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALE 1513
+E +I L EN E + ++ + E + V LN+Q+ +L + +
Sbjct: 571 -ARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE--ALALDKVGLNQQLLQLEEENQ 627
Query: 1514 EEVAKTNEMQTALENQEIEI 1533
++ + A ++++
Sbjct: 628 SVCSRMEAAEQARNALQVDL 647
>X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein.
Length = 2349
Score = 105 bits (252), Expect = 1e-21
Identities = 246/1449 (16%), Positives = 591/1449 (40%), Gaps = 111/1449 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDL---QEKINEKDQIIEAKNK--ATTXXX 197
DV L+ +KE + LQ+K+ ++ + + + ++++ ++ +++ ++N T
Sbjct: 144 DVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT 203
Query: 198 XXXXXXXXXXXXXXE--DTKQQMTKMQENFIAMEAEW---KDEKQRLLKDIESKDVRISS 252
E + K + +E +E + K + L K +E ++
Sbjct: 204 KTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE 263
Query: 253 LEEANKLLEAARFEISLE-HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
+E +E +F L H KL+ L + A + + +E E
Sbjct: 264 AKEQQASME-EKFHNELNAHIKLS-NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEAN 321
Query: 312 ---EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSP 368
+ LE+ + +K E+LE +I + KELEN + + + S++
Sbjct: 322 KAIQDHLLEVEQSKDQMEK-EMLE----KIGRLEKELENANDLLSATKRKGAILSEEELA 376
Query: 369 LISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+S + +K+ P +L +E N + + ++ + KLE + +NK L + +
Sbjct: 377 AMSPTAA--AVAKIVKPGMKL-TELYNAYVETQ-DQLLLEKLEN--KRINKYLDEIVKEV 430
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
K +A L ++ +Q M+ + + +T+ N+ + V E+ +
Sbjct: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMK--EIQRLQEDTDKANKQSSVLERDNRR 488
Query: 489 LNDEIKDVN--VKDLIEKLKSAEEQITQLNDEIDAAN-KNMIKVKSNHKLKLKQMQKTID 545
+ ++KD++ ++ L+ +L+ A ++E+ +A+ + +V S H + + +++
Sbjct: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
Query: 546 NFSKVSDSNKEI--VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
++ + +E+ R EE S K+ EL+ + + L R + + ++
Sbjct: 549 QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH 663
++ +L SQ + LH + S Q+ + + +
Sbjct: 609 RQRDM-------YRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK-EDIMNKLQNYIQENMDLTD 722
E I+A A+ K+L + EN K +K + + ++N++ E + ++ + +N ++
Sbjct: 662 STEAIEA-KAALKQLQEIFENYKKEKAE----NEKIQNEQLEKLQEQVTDLRSQNTKIST 716
Query: 723 KLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+L+ S E + + + E S + + A Q+++ I + +L
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR-------G 769
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E +AV E R +L+++ + L L E + + ++ ++ L L+ + + ++
Sbjct: 770 ANEKLAVAEVRAENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNL--LLTNLQTIQGI 825
Query: 841 LLEIEHENKE-LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
L E E K+ L + + L E +L+ L + + + L + L +T
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTET- 884
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN-EKYEKNIEYVT 958
+L N K + Q I K+ + ++E++ +Q + N E + + +
Sbjct: 885 --NLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E Q+ + K ++ NVE+ M + +++ + K++ + + + + +
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAM-VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
Q +++++ + ++ Q + E +L++ L +++ E+Q ++ + +
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
++ + R+ +Q K E + +E + M+ ++ +E + V
Sbjct: 1062 QQAR---RDCQEQAKIAVEAQNKYEREL-----MLHAADVEALQAAKEQVSKMASVRQHL 1113
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQEQIN 1197
+ + E + ++ ++ +E+ L E+ +C + LE N L + ++ + +
Sbjct: 1114 EETTQ-KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
Query: 1198 QLKSKLE-QLN---TENDNLLSTVAELRSSI--SSAVDQRGFEIAEL----WKQHLAQRE 1247
+K ++ LN +E + E+ I + + FE+A++ ++Q + E
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1248 ADFQKTEHEL-----RVQLSA-FESKYEQLLDSVQS-STQEETNKIVTMEQ------VTS 1294
+ Q+ E L +VQ++A +++E+L+ ++ + ETNK++ E+ +
Sbjct: 1233 RELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSE---IEDEKVAFXXXXXXXXXXXXXXXXD 1351
+Q K++ E + LQE A++ + +L++E +E++ + +
Sbjct: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
+ S K++ + I + EE +LK + + + ++ + E
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
++ K I + ++ V++ Y+ + E+L +++ ++ + +
Sbjct: 1413 IQKDLDAK----IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDK---VMETSAQSSGD 1465
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
H E E++ +K E LN T+S SL QV L K L E+ + +Q +
Sbjct: 1466 HQEQHVSVQEMQELK--ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
Query: 1532 EIVTLNDEI 1540
E+ L ++
Sbjct: 1524 ELSRLRQDL 1532
Score = 102 bits (244), Expect = 1e-20
Identities = 225/1182 (19%), Positives = 491/1182 (41%), Gaps = 87/1182 (7%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNN 970
+ L+++ +E + + ++ SA +V+++ +NIE + Q +L
Sbjct: 501 RVLLME-LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
Query: 971 I-ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
+ E +E + + ++ T+ + +++ ++++++Q+D I L+
Sbjct: 560 LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
Q A + S + D LA + + +++S + E L
Sbjct: 620 QTTGVAIPLHASSLDDV--SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL----- 672
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD-DANNVDXXXXXXXXXXXXLKVQEE- 1147
Q++E+ E + K + + E ++D + N +Q+
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLN 1207
E + +E + L E++ KL Q+ +II T+ +L G + E++ + + E L
Sbjct: 733 EGYRREITSLHERNQKLTATTQK-QEQII--NTMTQDLRGAN----EKLAVAEVRAENLK 785
Query: 1208 TENDNL-LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
E + L LS V + S +QRG L +L + +++E E + +LS+
Sbjct: 786 KEKEMLKLSEVRLSQQRESLLAEQRG---QNLLLTNLQTIQGILERSETETKQRLSSQIE 842
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQ---VTSLQNKLQ-DKEEHLR-NLQEKYADVINQIE 1321
K E + ++ + E + T+ + V L K Q D E +L N +E + +I
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXX-XXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
L+ + + +V D+ +Q +EQ +N+ +LK S
Sbjct: 903 TLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ----VNDLKERLKTS 958
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE-NVRQ 1439
+ V +A V L L K+ ++ ++ + + + EF+ + +
Sbjct: 959 T-----------SNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
+L+E EK ++L +K + + ++ E ++Q E + + ++ + ++
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNEQ 1062
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIE-IVTLNDEITNLQNMVRASSSKIQKHV 1558
+ E K + E E + L ++E + ++++ + ++ + QK
Sbjct: 1063 QARRDCQEQAK-IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
Query: 1559 SFASDTKQGRDEQLDNTMNKELLDAVPRAE-LDLAMYMLHQR 1599
S + K +E+ + + E+ V R E L+ +LH +
Sbjct: 1122 SQLLECKASWEER-ERMLKDEVSKCVCRCEDLEKQNRLLHDQ 1162
Score = 101 bits (241), Expect = 3e-20
Identities = 174/918 (18%), Positives = 395/918 (43%), Gaps = 91/918 (9%)
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEI 519
+E I + + EI + ++ K E N++I++ ++ L E++ Q T+++ ++
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAE-NEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 520 DAANKNMIKVKSN---HKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELE 575
D A+K ++ N ++ ++ + + + + ++I+ +T++L ++K+A E
Sbjct: 719 DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
Query: 576 EEKGNLQ-----LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-LLESQKFDLVQE 629
NL+ L L + + ES + ++ +NL T L+ I +LE + + Q
Sbjct: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQR 836
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLD 688
L ++E +IS L+ ++ +E++ H L +D K NL L+
Sbjct: 837 LS------SQIEKLEHEISHLKK-KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLN 889
Query: 689 -KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
KE L K++ K+ + N ++ T K + + E + +L++++ E+
Sbjct: 890 TKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI----AVMEDRRYSLERKADQLG 803
++ER ++ S + +Y++ + LEES+ V E+ R ++E + +
Sbjct: 950 D--------LKER---LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 804 SYLQEKQKAYSEYTIQEDELVN--RLAVLMDHDRVVE--KQLLEIEHENKE-LQKKNQIL 858
+ + +K E ++ EL + R A+ ++ E K L +++E +E LQ+ + L
Sbjct: 999 EFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
Query: 859 LEENQNLQISLSDMQQHYNALVEKANR---------TDLAESESTKYQ-TQLRDLESNLK 908
E Q + D Q+ VE N+ D+ ++ K Q +++ + +L+
Sbjct: 1059 SNEQQ----ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAI---RDKKVLNEKYEKNIEYVTQLEAQLQ 965
T + ++ +++ K E+ E ++ + D + N IE ++ + +
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS--DKVVA 1172
Query: 966 EYKNNIEN-LNMNVEELNKMNLELID--KHVQKQQTQSPDYTE----QYINEINKLNALL 1018
K ++ LN+++ E K ++++ + +++++ + E + + ++ L
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++ E +LN + QV+ +M E T + +M R K+ L+ Q
Sbjct: 1233 RELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE--QDL 1290
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+++Q VR+ + I L+E + + GM+ + + + +D
Sbjct: 1291 QQMQAKVRKLELDILPLQEANA----ELSEKSGMLQAEK-KLLEEDVKRWKARNQHLVSQ 1345
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
+E + + E+ V ++ +L E+ +I + N LT NQ I
Sbjct: 1346 QKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARS---NASLTN----NQNLIQS 1398
Query: 1199 LKSKLEQLNTEND----NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
LK L ++ TE + +L + + +++ + + + +I +K + +A K
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK--KIGRRYKTQYEELKAQQDKVM 1456
Query: 1255 HELRVQLSAFESKY---EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
+ ++ +++ + ++ Q ET QV +LQ L +KE RNLQE
Sbjct: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
Query: 1312 KYADVINQIEILRSEIED 1329
+ + +++ LR +++D
Sbjct: 1517 QTVQLQSELSRLRQDLQD 1534
Score = 95.5 bits (227), Expect = 1e-18
Identities = 223/1051 (21%), Positives = 450/1051 (42%), Gaps = 144/1051 (13%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLAQELEQXXXXXX 286
++ E ++ Q + D+ S++ +IS+ L+ A+K E + + ++ E+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
+Q I ++ EK ++ L K+ E+L+ ++ Q + L
Sbjct: 752 TTQKQ-----EQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLL 806
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
+ G + + +G I +S T ++ S +L E + KK +NE
Sbjct: 807 AE--QRGQNLLLTNLQTIQG---ILERSETETKQRLSSQIEKLEHEISHL---KKKLENE 858
Query: 407 IAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
+ + + ++L+ L+D + + + IA L+ +H +ME
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLK-QHLSNME----- 912
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
V ++ K Q K++ V DL+ +L+ EEQ+ L + + + N+
Sbjct: 913 -VQVASQSSQRTGKGQPSNKED---------VDDLVSQLRQTEEQVNDLKERLKTSTSNV 962
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEI-VRLTEELH---HLSQKVAELEEEKGNL 581
++ + ++++++ +V++ K I VRL E L +K+ E+E+EK L
Sbjct: 963 ----EQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Query: 582 QLHLVDYDSGRMIES------DVYKKMIEMENLAETRLK----AISLLESQKFDLVQELH 631
Q D R IES ++ K + ++N + L+ A+S + + D ++
Sbjct: 1019 Q-----DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK 1073
Query: 632 IL---QQKYD-EVEDKLADISQLQS--DQVCSEIKSV--HLEEQIDALSASKKELALVIE 683
I Q KY+ E+ AD+ LQ+ +QV S++ SV HLEE + K E L+
Sbjct: 1074 IAVEAQNKYERELMLHAADVEALQAAKEQV-SKMASVRQHLEE-----TTQKAESQLL-- 1125
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
K E+ +KD + + + ++ ++N L D++EK+S +++A +
Sbjct: 1126 ECKASWEERERMLKD---EVSKCVCRCEDLEKQNRLLHDQIEKLS----DKVVASVKEGV 1178
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
Q + + K QE+ L I + + I +A +E RY ++ + L
Sbjct: 1179 QGPLNVSLSEEGKSQEQILEI----LRFIRREKEIAETRFEVAQVESLRY--RQRVELLE 1232
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLM-DHDRVVEK-QLLEIEHE-NKELQKKNQILLE 860
LQE + + + E E V A M H+ +++K + + + E NK L+++ + L +
Sbjct: 1233 RELQELEDSLNA----EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQ 1288
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ Q +Q + ++ L E AN +L+E +S Q + + LE ++KR +Q L+ Q
Sbjct: 1289 DLQQMQAKVRKLELDILPLQE-AN-AELSE-KSGMLQAEKKLLEEDVKRWKARNQHLVSQ 1345
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
+K D E E+ +K+L+EK E + + + QL ++ K I N ++
Sbjct: 1346 QKDP--DTE-EY----------RKLLSEK-EVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYM 1040
N+ ++ + + + K +T+ + K D +II + +K+
Sbjct: 1392 -NQNLIQSLKEDLNKVRTEK--------------ETIQKDLDAKIIDIQEKVKT------ 1430
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKL 1100
++ + ++ T+ E ++ + +V + S ++E + V+E ++ELKET
Sbjct: 1431 --ITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE----MQELKETLN 1484
Query: 1101 TFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
E E + + T+ +A N+ L+ + +Q+R+ +
Sbjct: 1485 QAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLR-----QDLQDRTTQE 1539
Query: 1159 EQSAKLNTELQECYTK-IIQLETLNTELTG-HDVVNQEQINQLKSKLEQLNTENDNLLST 1216
EQ + TE +E K I+ ++ L G D + +E +LK + L+ + D L
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN-EELKQRNGALDQQKDELDVR 1598
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+ L+S + + E+ E ++HL QR+
Sbjct: 1599 ITALKSQYEGRISRLERELREHQERHLEQRD 1629
Score = 95.1 bits (226), Expect = 2e-18
Identities = 169/935 (18%), Positives = 393/935 (42%), Gaps = 80/935 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
T +S + +LQ ++ I L E+ N+K K +
Sbjct: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMTQDLRGA 770
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + + K +E E +++ LL + +++ +++L+ +LE +
Sbjct: 771 NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830
Query: 265 FE----ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
E +S + KL E+ L + + K +++ + +L + N
Sbjct: 831 TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL-N 889
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS--PLISR-----K 373
EL K + + + ++Q +E ++A+ ++ PS K L+S+ +
Sbjct: 890 TKELLKNAQ--KEI-ATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 374 SGRNTASKMKSPWSQLSS---------ETLNQDTD--KKINKNEIAKLEMVIQ---SLNK 419
+ ++K+ S + E+LN++ +++ KN +L+ + L K
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 420 DLVD----KEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS--LIHVGTNTE 473
L++ K+ + +K ++ +Q E Q+ ++ S L +
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR 1066
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQ-------LNDEIDAANKNM 526
D E AK+ + + + E+ ++ D +E L++A+EQ+++ L + A +
Sbjct: 1067 DCQEQAKIAVEAQNKYERELM-LHAAD-VEALQAAKEQVSKMASVRQHLEETTQKAESQL 1124
Query: 527 IKVKSNHKLKLKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQKVAELEEE--KGNLQL 583
++ K++ + + + ++ + + D K+ L +++ LS KV +E +G L +
Sbjct: 1125 LECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
Query: 584 HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
L + + ++ + + + +AETR + ++ +ES ++ Q + +L+++ E+ED
Sbjct: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFE-VAQVESLRYR--QRVELLERELQELEDS 1241
Query: 644 LADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L ++ + QV ++ + H E E ++ + + K L E L+ D +Q+ ++
Sbjct: 1242 LN--AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRK 1299
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAK 756
LE D + LQ + N +L++K + AEK + E + + Q + Q D +
Sbjct: 1300 LELD----ILPLQ---EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 757 -----IQERDLY---IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+ E++++ I+ + E+ + K+ I R S+ ++ SL+ +++ + +
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
QK I E V + + R + Q E++ + ++ + + ++Q +S
Sbjct: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ +MQ+ L + ++ ES+ Q L + E+ + + + QT+ +Q +
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNL--QEQTVQLQSELSRLRQ 1530
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+++ T E +R + + EK EK + + ++++ + L EEL + N
Sbjct: 1531 DLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-GA 1587
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+D+ + + QY I++L L++ E
Sbjct: 1588 LDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 66.1 bits (154), Expect = 1e-09
Identities = 138/767 (17%), Positives = 310/767 (40%), Gaps = 64/767 (8%)
Query: 98 LKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNA 157
L KE+L K+ L + S V+ DV L + +++ +
Sbjct: 888 LNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
Query: 158 LSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQ 217
++ L+ ++K + + Q + ++ + + + T +++
Sbjct: 948 VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKK 1007
Query: 218 MTKMQENFIAMEAEWKDEKQRLLKDIESK----DVRISSLE-EANKLLEAARFEISLEHS 272
+ ++++ + E +D+K+R ++ +E + +SS++ E + L+ A +S E
Sbjct: 1008 LMEVEKE----KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 273 --KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
+ QE + L +E K ++ + S+ ++ E T+K E
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR-QHLEETTQKAES 1122
Query: 331 LEHLNCQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK---MKSP 385
+ L C+ +E L+++++ + + ++ I + S + AS ++ P
Sbjct: 1123 -QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
Query: 386 WS-QLSSETLNQDTDKKI-----NKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+ LS E +Q+ +I + EIA+ + + + + E++
Sbjct: 1182 LNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELEDS 1241
Query: 440 XXXXGKDTLI-AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
+ + A+ +H++ M+ ++V T + + + +E+L+Q+L V
Sbjct: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM--LREEKERLEQDLQQMQAKVRK 1299
Query: 499 KDL-IEKLKSAEEQITQLNDEIDAANKNMIK-VKS----NHKLKLKQMQKTIDNFSKVSD 552
+L I L+ A ++++ + + A K + + VK N L +Q + + K+
Sbjct: 1300 LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLS 1359
Query: 553 SN----KEIVRLTEELHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM------IESDVYK 600
K I +LTEE+ L ++A N Q + + D ++ I+ D+
Sbjct: 1360 EKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDA 1419
Query: 601 KMIEMENLAET--RLKAISL--------LESQKFDLVQELHILQQKYDEVEDKLADISQL 650
K+I+++ +T ++K I L++Q+ +++ + E + ++ +L
Sbjct: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK- 709
+ +E KS LE Q++ L + E NL+ QL + L D +D +
Sbjct: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
Query: 710 --LQNYIQENMDLTDKLEKMSAEKISELLA---KINHEEQSKIQTQFGIDAKIQERDLYI 764
L+ I E + T K + KI+ L ++ E + Q +D + E D+ I
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
++S+ Y+ RI RLE + ++R + + + + E+Q+
Sbjct: 1600 TALKSQ---YEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
Score = 56.4 bits (130), Expect = 8e-07
Identities = 123/647 (19%), Positives = 256/647 (39%), Gaps = 39/647 (6%)
Query: 91 SESLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT 150
S L++K + +EK KQ + KR + + ++ + ++T
Sbjct: 997 SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
Query: 151 -IKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXX 209
+ + A Q + KI ++ Q K E++ ++ A +
Sbjct: 1057 ALSNEQQARRDCQEQAKIA----VEAQNKY-ERELMLHAADVEALQAAKEQVSKMASVRQ 1111
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDV-RISSLEEANKLLEAARFEIS 268
E+T Q K + + +A W +E++R+LKD SK V R LE+ N+LL ++S
Sbjct: 1112 HLEETTQ---KAESQLLECKASW-EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL--TK 326
+ +E Q I + EI E E+A + L +
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET-RFEVAQVESLRYRQ 1226
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
++ELLE + +ELE+ L + + + + L+ + N +
Sbjct: 1227 RVELLE-------RELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 387 SQLSSETLNQDTDKKINKNEIAKLEMV-IQSLNKDLVDKEYVI-SEKDTXXXXXXXXXXG 444
+ E L QD + K +L+++ +Q N +L +K ++ +EK
Sbjct: 1280 RE-EKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
Query: 445 KDTLIAQLQ---LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE----LNDEIKDVN 497
L++Q + E + + +H + EI +++ ++ + N++ +
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 498 VKDLIEKLKSAEEQITQLND----EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+K+ + K+++ +E I + D +I K + +VK + Q ++ KV ++
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETR 612
+ + +E H Q++ EL+E + +S ++ + +K E NL E
Sbjct: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
++ S L + DL +Q ++ +K + + V ++ K HL D L+
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEK---EEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
+EL L K++L I L++ E +++L+ ++E+ +
Sbjct: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
>X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin heavy
chain protein.
Length = 881
Score = 105 bits (251), Expect = 2e-21
Identities = 147/810 (18%), Positives = 349/810 (43%), Gaps = 60/810 (7%)
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE 509
A+ + E Q+ G L + T ED + Q++L+ + E+ V K L E+ +S E
Sbjct: 42 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT-VLKKALDEETRSHE 100
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLS 568
Q+ ++ + A + + + +L+Q ++ N K + KE L EL L
Sbjct: 101 AQVQEMRQKHAQAVEELTE-------QLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 153
Query: 569 QKVAELEEEKGNLQLHLVDYDS----GRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
Q E+E +K L+ + + S G +++ K+ +++N E+ ++ E +
Sbjct: 154 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 213
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-----LEEQIDALSASKKELA 679
L +++ L + + ++ L + ++ Q V ++++ + L++Q+D +K+ L
Sbjct: 214 KLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 272
Query: 680 LVIENLKLD----KEQLY---GTIKDLENDKEDIMNKLQNYIQ---ENMDLTDKLEKMSA 729
I L + K++L T++ LE K+ +++N Q E DKLEK +
Sbjct: 273 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK-TK 331
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
++ + L + + ++ Q ++ K ++ D + ++ SKY R E E
Sbjct: 332 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 391
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVLMDHDRVVEKQLL 842
+ SL R ++ +E ++ + ++LV+ + L R +E Q+
Sbjct: 392 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 451
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
E++ + +EL+ + Q + L++++ ++ + ++ R + E + + Q QL +
Sbjct: 452 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNEEKRRQLQRQLHE 509
Query: 903 LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
E+ L+ + KKK DL+ + Q +SAI+ + E+ I+ + +L+A
Sbjct: 510 YETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGR-------EEAIKQLRKLQA 561
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
Q+++++ +E+ + +E+ ++ +K ++ D Q ++ KQ D
Sbjct: 562 QMKDFQRELEDARASRDEI----FATAKENEKKAKSLEADLM-QLQEDLAAAERARKQAD 616
Query: 1023 EEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
E L +++ ++ ++ + E+++AQ +LE + M+ +S ++ + Q E
Sbjct: 617 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 676
Query: 1080 ELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
+L + + ++ + ++ E + + S + M +
Sbjct: 677 QLSNELATERSTAQKNESSRQQLER-----QNKELRSKLHEMEGAVKSKFKSTIAALEAK 731
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
++ E+ +E+ + + + +L+E ++ + + ++ QL
Sbjct: 732 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 791
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
K +LE+ E+ + + +L+ + A +
Sbjct: 792 KRQLEEAEEESQRINANRRKLQRELDEATE 821
Score = 93.9 bits (223), Expect = 4e-18
Identities = 151/747 (20%), Positives = 319/747 (42%), Gaps = 67/747 (8%)
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
E+ +KN L ++ + L+ +SD+Q+ ++ E+A R AE + +L L++ L+
Sbjct: 11 EIAQKNNAL-KKIRELEGHISDLQEDLDS--ERAARNK-AEKQKRDLGEELEALKTELED 66
Query: 910 I---THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
T Q L ++++E+ L+ + + S + + +K+ + +E +T+ QL++
Sbjct: 67 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE---QLEQ 123
Query: 967 YKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSPDYTEQYIN-EINKLNALLKQKDEE 1024
+K NL+ N + L K N +L + V Q Q ++ ++ + ++ +L + +
Sbjct: 124 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 183
Query: 1025 IIALNQKINNAQ---VSYMSMVSDYESK-------LAQFTTKLENMEEEMQRVSKQLLDS 1074
LN K++ Q S M+++ E K +A +++L++ +E +Q ++Q L+
Sbjct: 184 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 243
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+L+ DQ+ E E K E +I T + +S + + + D A+ V+
Sbjct: 244 STKLRQLEEERNSLQDQLDEEMEAKQNLERHI-STLNIQLSDSKKKLQDFASTVEALEEG 302
Query: 1135 XXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE 1194
+++ + +E++ ++ K LQ+ +L+ L VV+ +
Sbjct: 303 KKRFQK--EIENLTQQYEEKAAAYDKLEKTKNRLQQ------ELDDL--------VVDLD 346
Query: 1195 QINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
QL S LE+ + D LL AE ++ S D+R AE RE + K
Sbjct: 347 NQRQLVSNLEKKQRKFDQLL---AEEKNISSKYADERDRAEAE-------AREKE-TKAL 395
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYA 1314
R A E+K E L+ + E +V+ + + + + E+ R L+ +
Sbjct: 396 SLARALEEALEAKEE--LERTNKMLKAEMEDLVSSKD--DVGKNVHELEKSKRALETQME 451
Query: 1315 DVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
++ Q+E L E++ + A DL+ ++ ++ + Q ++E
Sbjct: 452 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 511
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD-SEIYQKTHEYTITLTQRNDE 1433
+L+ + + + K LEL +K E ++ + + E
Sbjct: 512 TELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 569
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E+ R E ++ +K L +++ E+ E +K++++E+ +L EEL
Sbjct: 570 LEDARASRDEIFATAKE-NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL-- 626
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
S+S + + + LE +A +++ LE ++ + ++D + S++
Sbjct: 627 --ASSLSGRNALQDEKRRLEARIA---QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 681
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKEL 1580
+ S A + R +QL+ NKEL
Sbjct: 682 LATERSTAQKNESSR-QQLER-QNKEL 706
Score = 80.6 bits (190), Expect = 4e-14
Identities = 161/856 (18%), Positives = 350/856 (40%), Gaps = 62/856 (7%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKIN-EKDQIIEA-KNKATTXXXXXXX 201
+ L + I +K+NAL K++ +E I DLQE ++ E+ +A K K
Sbjct: 5 LARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 60
Query: 202 XXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRL--LKDIESKDVRISSLEEANKL 259
T+Q++ +E + + + DE+ R + E + ++EE +
Sbjct: 61 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 120
Query: 260 LEA-ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLE 317
LE R + +L+ +K E E + + E + E++ K S
Sbjct: 121 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 180
Query: 318 IANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRN 377
EL K+ L++ + E E K + + ++SS + L+ ++ +
Sbjct: 181 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 240
Query: 378 TASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
K + +L D+++ + LE I +LN L D + + +
Sbjct: 241 LNVSTKLRQLEEERNSLQDQLDEEMEAKQ--NLERHISTLNIQLSDSKKKLQD---FAST 295
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV- 496
GK +++ QQ+ E + +++ K + +L+QEL+D + D+
Sbjct: 296 VEALEEGKKRFQKEIENLTQQYEEKAAAY---------DKLEKTKNRLQQELDDLVVDLD 346
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
N + L+ L+ + + QL E + + + + ++ + + ++ + E
Sbjct: 347 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 406
Query: 557 IVRLTEELHH-LSQKVAELEEEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENLAETRLK 614
E + L ++ +L K ++ ++ + + S R +E+ + + ++E L E L+
Sbjct: 407 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL-EDELQ 465
Query: 615 AISLLESQKFDLVQELHILQQKYD---EVEDKLADISQLQSDQVCSEIKSVHLEE--QID 669
A E K L + L+ +++ + D+ + + Q + E ++ +E Q
Sbjct: 466 AT---EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 522
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+A+KK+L +++L+L + ++ + +++++ +E D +++ A
Sbjct: 523 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 582
Query: 730 E-KISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKYKSRICRLEESIAV 787
K +E AK + ++Q + +++ DL E + EL+ S L++
Sbjct: 583 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 642
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
+E R LE + ++ ++ + T Q ++L N LA + E ++E +
Sbjct: 643 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESSRQQLERQ 702
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
NKEL+ K L +M+ V+ ++ +A E+ ++ LE +
Sbjct: 703 NKELRSK--------------LHEME----GAVKSKFKSTIAALEA-----KIAQLEEQV 739
Query: 908 KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
++ E Q K++ + L+ E Q+E + + E+ EK V QL+ QL+E
Sbjct: 740 EQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 798
Query: 968 KNNIENLNMNVEELNK 983
+ + +N N +L +
Sbjct: 799 EEESQRINANRRKLQR 814
Score = 80.2 bits (189), Expect = 6e-14
Identities = 129/643 (20%), Positives = 272/643 (42%), Gaps = 47/643 (7%)
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLE 332
KLA+++ +Q + S + + EE+ SL+ E+ K L
Sbjct: 214 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 273
Query: 333 H---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMKSPWSQ 388
H LN Q+ + K+L++ +T+ + K+ L + + A K++ ++
Sbjct: 274 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 333
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
L E + D + ++ LE + ++ L +++ + S+ K+T
Sbjct: 334 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 393
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVNVKD-----LI 502
L ++ +E + E N++ K + E L +D K+V+ + L
Sbjct: 394 ALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 447
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
+++ + Q+ +L DE+ A ++++ N + Q ++ + + ++ + +L
Sbjct: 448 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQR 505
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLL 619
+LH ELE+E+ L + + +E D+ ++ ++ + R +K + L
Sbjct: 506 QLHEYE---TELEDERKQRALAAA---AKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 559
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
++Q D +EL + DE+ A + + E + L+E + A ++K+
Sbjct: 560 QAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 616
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTDKLEKMS--AE 730
L E L + L+++K + + +L+ ++E NM+ ++D++ K + AE
Sbjct: 617 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 676
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVME 789
++S LA Q ++ ++ + +E + +E + SK+KS I LE IA +E
Sbjct: 677 QLSNELATERSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 736
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HDRV--VEKQLL 842
++ R+ L++K K E +Q EDE + + + + RV +++QL
Sbjct: 737 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 796
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
E E E++ + + L E S M + NAL K R
Sbjct: 797 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 839
Score = 51.2 bits (117), Expect = 3e-05
Identities = 80/399 (20%), Positives = 163/399 (40%), Gaps = 33/399 (8%)
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
++L+ + +N L + EL IS + +L + A+ +A+ QK +L +
Sbjct: 6 ARLDDEIAQKNNALKKIRELEGHISDLQE-------DLDSERAARNKAEKQK--RDLGEE 56
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK----EEHLRNLQEKYADV 1316
L A +++ E LDS ++TQ+E + ++VT L+ L ++ E ++ +++K+A
Sbjct: 57 LEALKTELEDTLDS--TATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 113
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-----------QMQE- 1364
+ ++ + + K +LR Q+ + Q+QE
Sbjct: 114 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 173
Query: 1365 QSILNINEE-NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEY 1423
QS + E A+L +N+AE K ++L + S++ Q T E
Sbjct: 174 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQEL 232
Query: 1424 TITLTQRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESEI 1482
T++ +QL E ++D L E E++ + R N ++ +K +
Sbjct: 233 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 292
Query: 1483 -ERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTALENQEIEIVTLNDEI 1540
V+ +EE + + + Q E A +++ KT N +Q L++ +++ +
Sbjct: 293 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 352
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+NL+ R + + + +S RD KE
Sbjct: 353 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 391
>U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein.
Length = 1017
Score = 105 bits (251), Expect = 2e-21
Identities = 159/719 (22%), Positives = 330/719 (45%), Gaps = 57/719 (7%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGT-NTEDVNEIAKVQ-EQLKQELND-EIKDVNVKDLIEKL 505
+ L+ E Q E L+ + N++ E K Q E++ + L E+ V ++ E L
Sbjct: 59 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 118
Query: 506 -KSAEEQITQLN--DEIDAANKNMIKVKSNHKLKLKQMQKTIDNF--SKVSDSNKEIVRL 560
K +E+ QL+ D++ ++ K+ ++ K ++++K+ KT +++ + N+ + L
Sbjct: 119 TKQIQEKQGQLSELDKLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 178
Query: 561 T--EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
+E+ +++ + E+ + + ++ R+ E+D K++ ++ L E+ A L
Sbjct: 179 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARL-EADEKKQLCVLQQLKESEHHA-DL 236
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
L+ + +L +EL I + + + L+++ E+++ L+ +I+ ++ S + L
Sbjct: 237 LKGRVENLERELEIARTNQEH--------AALEAENSKGEVET--LKAKIEGMTQSLRGL 286
Query: 679 ALVIENLKLDKEQLYGTI-KDLENDKE-DIMNK-LQNYIQEN-MDLTDKLEKMSA--EKI 732
L + ++ +KE L + K+ E E +I+N +N +QE + EK S E +
Sbjct: 287 ELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 346
Query: 733 SELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
L E Q I T+ + AK Q +E +E E ++ + + + V++
Sbjct: 347 QTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 406
Query: 793 YSLERKADQLGSYLQEKQKAYSEYTIQ---EDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
L ++ + L++K + S Q +++LV++L+ + ++ ++Q LE+ +
Sbjct: 407 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV 466
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
EL++K Q+L +N +LQ +L +Q Y L + T + + + ++ E+ L+R
Sbjct: 467 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 526
Query: 910 ITHEHQTLIVQKKKEIED----LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
HE + ++E+ L E +E K L E +N E L+
Sbjct: 527 EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM-- 584
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-- 1023
+K+ +E EE+ + L L + +K Q D +QY EI L K+E
Sbjct: 585 -HKDQVEKEGKVREEIAEYQLRLHEAE-KKHQALLLDTNKQYEVEIQTYREKLTSKEECL 642
Query: 1024 -----EIIAL---NQKINNAQVSYMSMVSDY-ESKL--AQFTTKLENMEEEMQRVSKQLL 1072
EI L +++NN+ + ++ + ++K+ ++ +L+ E Q K L+
Sbjct: 643 SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLI 702
Query: 1073 DS-KQHNEELQILVRE----QDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
S KQ EE +IL +E Q Q K+ T + +++ TE + T+E + +A+
Sbjct: 703 KSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 761
Score = 83.4 bits (197), Expect = 6e-15
Identities = 160/738 (21%), Positives = 315/738 (42%), Gaps = 59/738 (7%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L +EV I +L+ E K +H+ E++ L +ENL+ +
Sbjct: 10 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERE---- 65
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE-KISEL-LAKINHEEQSKIQTQ 750
++ E ++E ++ +N E L ++E+M+ K+ EL L + E+++ +
Sbjct: 66 ---LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 122
Query: 751 FGIDAKIQERDLYIENIESEL-SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL--Q 807
++ E D + + +S+L K ++ I EES +E + L+ + + + Q
Sbjct: 123 QEKQGQLSELDKLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 182
Query: 808 EKQKAYSEYTI-----QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
E KA +E ++ +E +L N + L EK+ L + + KE + +L
Sbjct: 183 EIMKA-TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 241
Query: 863 QNLQISLSDMQQHY-NALVEKANRTDLAESESTKYQ--TQ-LRDLESNLKRITHEHQTLI 918
+NL+ L + + +A +E N E+ K + TQ LR LE ++ I E + L
Sbjct: 242 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLT 301
Query: 919 --VQKKKE-IEDLEIEFNTQIESAIRDK---KV-LNEKYEKNIEYV-TQLEAQLQEYKNN 970
+QK++E I +LEI N+ E+ +++K KV + EK +E + TQL++ ++E++
Sbjct: 302 NELQKEQERISELEI-INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPC 360
Query: 971 I----------ENLNMNVE--ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
I +NL+ VE EL K L + I E+ L
Sbjct: 361 IMTKKPVSAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL 420
Query: 1019 KQKDEEIIALNQKINNAQ--VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ 1076
++KDEEI L +I + + VS +S V + +L N+ E+++ Q+L SK
Sbjct: 421 EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQ-KIQVLQSK- 478
Query: 1077 HNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXX 1136
N LQ + K L+ E+ + K + M + M+ +
Sbjct: 479 -NASLQDTLEVLQSSYKNLEN-----ELELTKMDKMSFVEKVNKMTAKETELQREMHEMA 532
Query: 1137 XXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL-TGHDVVNQEQ 1195
L +EE E++ L + L E++ ++ +L N+EL D ++++Q
Sbjct: 533 QKTAEL----QEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 588
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ + E++ L + ++ + Q EI + +++ L +E +
Sbjct: 589 VEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEI-QTYREKLTSKEECLSSQKL 647
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
E+ + S+ E L + Q + + K+ ++ V L+ + + + ++ L +
Sbjct: 648 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 707
Query: 1316 VINQIEILRSEIEDEKVA 1333
+ + EIL+ E+ + A
Sbjct: 708 LEEEKEILQKELSQLQAA 725
Score = 81.4 bits (192), Expect = 2e-14
Identities = 162/746 (21%), Positives = 330/746 (44%), Gaps = 71/746 (9%)
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
+ +L V ++ D EK+ L I + KE +N L ++ +NL+ L +++ ++ A
Sbjct: 24 IEKLRVRIEAD---EKKQLHIAEKLKERDGENDSLKDKVENLERELQMSEENQELVILDA 80
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
+ AE E+ K TQ+ ++ +LK + TL +K+ + ++ E Q+ DK
Sbjct: 81 ENSK-AEVETLK--TQIEEMARSLKVFELDLVTLRSEKENLTKQIQ-EKQGQLSEL--DK 134
Query: 944 KVLNEKYEKNIEYVTQLEAQL-QEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSP 1001
L ++ +E Q E Q+ +E K +E L ++ELN+ L D+ + K QS
Sbjct: 135 --LLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL 192
Query: 1002 D----YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
D Q N I KL A L+ +++ + + Q++ S++ + L + ++
Sbjct: 193 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE---------SEHHADLLK--GRV 241
Query: 1058 ENMEEEMQ--RVSKQ--LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
EN+E E++ R +++ L+++ E++ L + + + L+ +L ++ ++E
Sbjct: 242 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL--DVVTIRSEKED 299
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
+++ ++ + + ++ +QE+E QE+ ++E+S+ E+ +
Sbjct: 300 LTNELQKEQERISELEIINSSFENI-----LQEKE---QEKVQMKEKSSTA-MEMLQTQL 350
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS---ISSAVDQ 1230
K E +T V +EQ L S++E L E LL + E +++ + S+V+
Sbjct: 351 KSSMREWQPCIMTKKPVSAKEQ--NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 408
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ---SSTQEETNKIV 1287
E+ E KQ L +++ + + +++++ Q SK Q+ Q E N V
Sbjct: 409 LIQEV-EDGKQKLEKKDEEISRLKNQIQDQ-EQLVSKLSQVEGEHQLWKEQNLELRNLTV 466
Query: 1288 TMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX 1346
+EQ + LQ+K ++ L LQ Y ++ N++E+ + +K++F
Sbjct: 467 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM----DKMSFVEKVNKMTAKET 522
Query: 1347 XXXXDLRTENQSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLE 1404
++ Q ++QE+ N QL N K L+
Sbjct: 523 ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLD 582
Query: 1405 LTHQLEL-KDSEIYQKTHEYTITLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESE 1458
H+ ++ K+ ++ ++ EY + L + + + + +Q VE + E LT KE
Sbjct: 583 CMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT-SKEEC 641
Query: 1459 LAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAK 1518
L+ +L++ + E + + +++EEL K T+ +L K V +L K E K
Sbjct: 642 LSSQKLEIDLLKSSKEELNNSLK-ATTQILEEL--KKTKMDNL-KYVNQLKKENERAQGK 697
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQ 1544
+ + + E E L E++ LQ
Sbjct: 698 MKLLIKSCKQLEEEKEILQKELSQLQ 723
Score = 73.3 bits (172), Expect = 6e-12
Identities = 138/702 (19%), Positives = 304/702 (43%), Gaps = 53/702 (7%)
Query: 307 KTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKG 366
K+++EEK EI E +E+L++ Q+++ N E A G + ++
Sbjct: 140 KSQLEEKEQAEIQIKEESKTAVEMLQN---QLKELN---EAVAALCGDQEIMKATEQSLD 193
Query: 367 SPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY 426
P+ RN+ K+++ + L K +++ L+ +++L ++L E
Sbjct: 194 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL---EI 250
Query: 427 VISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL--IHVGTNTEDV-NEIAKVQE 483
+ ++ +TL A+++ Q + G L + + + ED+ NE+ K QE
Sbjct: 251 ARTNQEHAALEAENSKGEVETLKAKIE-GMTQSLRGLELDVVTIRSEKEDLTNELQKEQE 309
Query: 484 QLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
++ EL EI + + +++ L+ E++ Q+ ++ A M +++ K +++ Q
Sbjct: 310 RI-SEL--EIINSSFENI---LQEKEQEKVQMKEKSSTA---MEMLQTQLKSSMREWQPC 360
Query: 544 IDNFSKVSDSNKEIVRLTEELH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM 602
I VS + + E L +Q + L+E K N + L +G + E + K+
Sbjct: 361 IMTKKPVSAKEQNLSSQVECLELEKAQLLQGLDEAKNN-YIVLQSSVNGLIQEVEDGKQK 419
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVCSEIKS 661
+E ++ +RLK + Q + ++ Q + E +L +++ +L+ + K+
Sbjct: 420 LEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKN 479
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT 721
L++ ++ L +S K L +E K+DK + + + ++ ++ Q+ +L
Sbjct: 480 ASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ 539
Query: 722 DKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL 781
++L EL + + SK Q + + ++ +L ++++ + ++
Sbjct: 540 EELSGEKNRLAGELQLLLEEIKSSKDQLK---ELTLENSELK-KSLDCMHKDQVEKEGKV 595
Query: 782 EESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQL 841
E IA + R + E+K L L + K Y E E+ L + + Q
Sbjct: 596 REEIAEYQLRLHEAEKKHQAL---LLDTNKQY------EVEIQTYREKLTSKEECLSSQK 646
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
LEI +L K ++ E N +L+ + +++ ++ + + E+ + Q +++
Sbjct: 647 LEI-----DLLKSSK--EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 699
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV--LNEKYEKNIEYVTQ 959
L + K++ E + L +KE+ L+ Q + D KV L + ++ E + +
Sbjct: 700 LLIKSCKQLEEEKEIL----QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 755
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMN--LELIDKHVQKQQTQ 999
+ EY + +L ++ E+L K LE H+ QQ++
Sbjct: 756 KTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 797
Score = 58.8 bits (136), Expect = 1e-07
Identities = 99/528 (18%), Positives = 222/528 (42%), Gaps = 38/528 (7%)
Query: 233 KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXX 292
+ EK+ L +++ + RIS LE N E + QE EQ
Sbjct: 294 RSEKEDLTNELQKEQERISELEIINSSFE-----------NILQEKEQEKVQMKEKSSTA 342
Query: 293 XXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATM 352
+ + ++ S E A L+ ++E LE Q+ Q E +N +
Sbjct: 343 MEMLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 402
Query: 353 GTESKAVSSPSKKGSPLISRKSGRNTASKMK-SPWSQLSSETLNQDTDKKINKNEIAKLE 411
+ + + G + +K + K + QL S+ + + ++ K +
Sbjct: 403 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQ----N 458
Query: 412 MVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK-DTLIAQLQLEHQQHMEGPSLIHVGT 470
+ +++L +L K V+ K+ L +L+L M ++ T
Sbjct: 459 LELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMT 518
Query: 471 NTE-----DVNEIAKVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLNDEIDAAN 523
E +++E+A+ +L++EL+ E + ++ L+E++KS+++Q+ +L E
Sbjct: 519 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 578
Query: 524 KNMIKVKSNHKLKLKQMQKTIDNFS-KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
K++ + + K ++++ I + ++ ++ K+ L + + + + EK +
Sbjct: 579 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 638
Query: 583 LHLVDYDSGRMIESDVYK-KMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE 641
+ S + +E D+ K E+ N + + + L+ K D ++ ++ L+++ + +
Sbjct: 639 EECL---SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQ 695
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
K+ + ++S + E K + +E +A +K+ + + K+D +L IK+L+
Sbjct: 696 GKMKLL--IKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVD--ELTTEIKELKE 751
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL-AKINH--EEQSK 746
E+ + Y+ + L EK+ EK E+L ++ H +QSK
Sbjct: 752 TLEEKTKEADEYLDKYCSLLISHEKL--EKAKEMLETQVAHLCSQQSK 797
>AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20-7
protein.
Length = 623
Score = 105 bits (251), Expect = 2e-21
Identities = 133/596 (22%), Positives = 270/596 (45%), Gaps = 57/596 (9%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKA----DQLGSYLQEKQKAYSEYTIQ 819
+E E E+++ +SRI ++ + +++ ER A ++ S Q+ ++A + +
Sbjct: 40 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE 99
Query: 820 EDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQ-ISLSDMQQHYN 877
DE + + + +R+ ++++L ++ E ++ KK+ E+ LQ + ++ +
Sbjct: 100 MDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE--EQIAKLQKLHEKELARKEQ 157
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN---T 934
L +K + E K L +S +I+ E + Q+ +E+LE++ T
Sbjct: 158 ELTKKLQTREREFQEQMK--VALEKSQSEYLKISQEKEQ---QESLALEELELQKKAILT 212
Query: 935 QIESAIRDKKVLNEKYEKNI-EYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLEL---I 989
+ E+ +RD + E Y I E + LE LQE KN ++L +++E E NK N+E+ +
Sbjct: 213 ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNMEITVMV 272
Query: 990 DKHVQKQQT----QSPDYTE-------QYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
+KH + ++ Q +TE QY E+ KL +Q+ E ++ + I A +
Sbjct: 273 EKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIE 332
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
M+ + KL T+LE++ E+ V K + EEL +L ++Q D++K+ E
Sbjct: 333 EMNEKT--LEKLDVKQTELESLSSELSEVLKA---RHKLEEELSVL-KDQTDKMKQELEA 386
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
K+ + N + + + S I+ + L + ++ + ++ ++
Sbjct: 387 KMDEQKNHHQQQ---VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 443
Query: 1159 EQSAKLNT---ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
A + ELQ+ K+ ++ + +EQ+ QL+ KL L TE L
Sbjct: 444 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK 503
Query: 1216 TVAEL---RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
VAE+ + + + +D ++ +L +Q +K E+ ++ + YE L
Sbjct: 504 QVAEVEAQKKDVCTELDAHKIQVQDLMQQ--------LEKQNSEMEQKVKSLTQVYESKL 555
Query: 1273 DSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+ + QE+T +I+ ++ LQ + K+E + L +K + + I IL E E
Sbjct: 556 ED-GNKEQEQTKQILVEKENMILQMREGQKKE-IEILTQKLSAKEDSIHILNEEYE 609
Score = 90.6 bits (215), Expect = 4e-17
Identities = 120/567 (21%), Positives = 254/567 (44%), Gaps = 60/567 (10%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
+ + +LK E++++IK + K++EE+ L E+ + ++ V K
Sbjct: 91 EARRKLKAEMDEQIKTIE--------KTSEEERISLQQELSRVKQEVVDVMK------KS 136
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY 599
++ I K+ + KE+ R +EL Q +E+ + L + ++ +
Sbjct: 137 SEEQIAKLQKLHE--KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 194
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
++ + +E L + ++ E++ DL QE + + E+E L LQ ++ S+
Sbjct: 195 QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE--KSLQENKNQSKD 252
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
+VHLE + + E+ +++E K + E L L +K ++ Q Y E
Sbjct: 253 LAVHLEAE---KNKHNMEITVMVEKHKTELESLKHQQDALWTEKLQVLK--QQYQTEMEK 307
Query: 720 LTDKLE--KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
L +K E K + K E++ + + EE ++ +T +D K E +E++ SELS+
Sbjct: 308 LREKCEQEKETLLKDKEIIFQAHIEEMNE-KTLEKLDVKQTE----LESLSSELSEVLKA 362
Query: 778 ICRLEESIAVMEDR----RYSLERKADQLGSYLQEKQKAY---SEYTIQEDEL-----VN 825
+LEE ++V++D+ + LE K D+ ++ Q++ + E +IQ E +N
Sbjct: 363 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN 422
Query: 826 RLAVLM-DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+L +L+ + D+ +++ +E+ ++++ L + + L D+ Q Y + +
Sbjct: 423 QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL-----DVFQSYQSATHE-- 475
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK----------EIEDLEIEFNT 934
+T E + + Q +L DLE+ +T + + QKK +++DL +
Sbjct: 476 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEK 535
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q + K L + YE +E + + Q ++ EN+ + + E K +E++ + +
Sbjct: 536 QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS 595
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQK 1021
++ E+Y + K K+K
Sbjct: 596 AKEDSIHILNEEYETKFKKKKKKKKKK 622
Score = 87.0 bits (206), Expect = 5e-16
Identities = 113/613 (18%), Positives = 257/613 (41%), Gaps = 36/613 (5%)
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI-EDLEIEFNTQIESAIRDKKVLNEK 949
+E TK TQLRD ++ ++++ + +I + K+++ E LE++ + R K++ +
Sbjct: 2 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQG 61
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELID--KHVQKQQTQSPDYTEQY 1007
E + A +E + + E K+ E+ + K ++K + +Q
Sbjct: 62 EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 121
Query: 1008 INEINK-LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
++ + + + ++K+ EE IA QK++ +++ K + T KL+ E E Q
Sbjct: 122 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA---------RKEQELTKKLQTREREFQE 172
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
K L+ Q +E L+I ++ + L+E +L + + ++E + E +
Sbjct: 173 QMKVALEKSQ-SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 231
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
++ K Q ++ + + + + ++ +++ T++ L+ L
Sbjct: 232 ILELESSLEKSLQEN-KNQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESLKHQQDALW 290
Query: 1187 GH--DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE---IAELWKQ 1241
V+ Q+ +++ E+ E + LL + + ++++ E + + +
Sbjct: 291 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 350
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
L+ ++ K H+L +LS + + +++ +++ E+ N +QV S+ +++
Sbjct: 351 SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH--HQQQVDSI---IKE 405
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN----- 1356
E ++ ++ D INQ+E+L E + +L+ +
Sbjct: 406 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 465
Query: 1357 -QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
QSY+ + E+ AQL++ +V + EA+ ++ +L+ +
Sbjct: 466 FQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQ 525
Query: 1416 IYQKTHEYTITLTQRNDEFENVRQQLVE-YEKRIEDLTYEKESELAILRLKMHENANHYE 1474
+ + L ++N E E + L + YE ++ED E+E IL K + E
Sbjct: 526 VQDLMQQ----LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE 581
Query: 1475 TMQKESEIERVKL 1487
+KE EI KL
Sbjct: 582 GQKKEIEILTQKL 594
Score = 84.6 bits (200), Expect = 3e-15
Identities = 122/628 (19%), Positives = 281/628 (44%), Gaps = 43/628 (6%)
Query: 445 KDTLIAQLQLEHQ--QHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
K LI QL+ + +E + + ++E +++E+ +L IK + +
Sbjct: 4 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQG-- 61
Query: 503 EKLKSAEEQITQLN-DEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLT 561
E+L+ +E+ + +E++ A K + + +M + I K S+ +E + L
Sbjct: 62 EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE--EERISLQ 119
Query: 562 EELHHLSQKVAEL-----EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+EL + Q+V ++ EE+ LQ L + + R E ++ KK+ E + ++K +
Sbjct: 120 QELSRVKQEVVDVMKKSSEEQIAKLQ-KLHEKELARK-EQELTKKLQTREREFQEQMK-V 176
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC--SEIKSVHLEEQIDALSAS 674
+L +SQ + L I Q+K + L ++ +LQ + SE K L+++ +
Sbjct: 177 ALEKSQS----EYLKISQEKEQQESLALEEL-ELQKKAILTESENKLRDLQQEAETYRTR 231
Query: 675 KKELALVIE-NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
EL +E +L+ +K Q LE +K ++ ++++ + L+ +
Sbjct: 232 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESLKHQQDALWT 291
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
E L + + Q++++ + QE++ +++ E + + E+++ ++ ++
Sbjct: 292 EKLQVLKQQYQTEMEKLR--EKCEQEKETLLKDKEIIFQAHIEEMN--EKTLEKLDVKQT 347
Query: 794 SLERKADQLGSYLQEKQKAYSEYTI---QEDELVNRLAVLMDHDRVVEKQLLE--IEHEN 848
LE + +L L+ + K E ++ Q D++ L MD + +Q ++ I+
Sbjct: 348 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 407
Query: 849 KELQKKNQILLEENQNLQISLSDMQQH---YNALVEKANRTDLAESESTKYQTQLR-DLE 904
+Q+ + L ++ L++ L + +H + A VE D+ SE Q + D+
Sbjct: 408 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLE-ADIKRSEGELQQASAKLDVF 466
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA-- 962
+ + THE ++ +++ ++ T E + K+V + +K + T+L+A
Sbjct: 467 QSYQSATHEQTKAYEEQLAQLQQKLLDLET--ERILLTKQVAEVEAQKK-DVCTELDAHK 523
Query: 963 -QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
Q+Q+ +E N +E+ K ++ + ++ + + + + N + + + +
Sbjct: 524 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 583
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESK 1049
+EI L QK++ + S + +YE+K
Sbjct: 584 KKEIEILTQKLSAKEDSIHILNEEYETK 611
Score = 68.9 bits (161), Expect = 1e-10
Identities = 95/552 (17%), Positives = 233/552 (42%), Gaps = 22/552 (3%)
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
I + D + +E+ G + E ++ E ++E + +L R+ KQ+
Sbjct: 8 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL-----RSRI--KQMTTQ 60
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E +E ++K++ E +S + + ++ + E T + ++ L+
Sbjct: 61 GEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI-SLQ 119
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
L R+ E +++K E + +++ + E A +++++ + + E+ Q++ L
Sbjct: 120 QELSRVKQEVVD-VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL 178
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++ ++ ++ E+ + LE ++ + T+S + E + + +
Sbjct: 179 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESS 238
Query: 1025 II-ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
+ +L + N ++ + + ++ + T +E + E++ + Q E+LQ+
Sbjct: 239 LEKSLQENKNQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESLKHQ--QDALWTEKLQV 296
Query: 1084 LVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA-NNVDXXXXXXXXXXXXL 1142
L ++ ++++L+E + + K + +I + IE M++ +D L
Sbjct: 297 LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 356
Query: 1143 K--VQEEEEFIQERSVLQEQSAKLNTELQECYT--KIIQLETLNTELTGHDVVNQEQINQ 1198
++ + +E SVL++Q+ K+ EL+ K + +++ + H+V Q
Sbjct: 357 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 416
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR 1258
LK ++ QL + E ++ + + + + +E Q + + FQ +
Sbjct: 417 LKDQINQLELLLKERDKHLKEHQAHVENL--EADIKRSEGELQQASAKLDVFQSYQSATH 474
Query: 1259 VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
Q A+E EQL Q ET +I+ +QV ++ + +D L + + D++
Sbjct: 475 EQTKAYE---EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQ 531
Query: 1319 QIEILRSEIEDE 1330
Q+E SE+E +
Sbjct: 532 QLEKQNSEMEQK 543
Score = 68.5 bits (160), Expect = 2e-10
Identities = 95/449 (21%), Positives = 196/449 (43%), Gaps = 44/449 (9%)
Query: 1160 QSAKLNTELQECYTKIIQLET------LNTELTGHDVVN--QEQINQLKSKLEQLNTEND 1211
+ KL T+L++ I QLE T+ H+ + +E+I QL+S+++Q+ T+ +
Sbjct: 3 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 62
Query: 1212 NLL--------STVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA 1263
L + EL ++S+A Q+ E K + ++ +KT E R+ L
Sbjct: 63 ELREQKEKSERAAFEELEKALSTA--QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 120
Query: 1264 FESKYEQ-LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL-RNLQEKYADVINQIE 1321
S+ +Q ++D ++ S++E+ K+ + + +L KE+ L + LQ + + Q++
Sbjct: 121 ELSRVKQEVVDVMKKSSEEQIAKLQKLHE-----KELARKEQELTKKLQTREREFQEQMK 175
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + + E + +L + ++ E + ++ +E A+ ++
Sbjct: 176 VALEKSQSE---YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQE-AETYRTR 231
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVR-QQ 1440
+ N ++K +L LE +E + E T+ + + E E+++ QQ
Sbjct: 232 ILELESSLEKSLQENKNQSK--DLAVHLE---AEKNKHNMEITVMVEKHKTELESLKHQQ 286
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS 1500
+ ++++ L + ++E+ LR K + ET+ K+ EI IEE+N K E +
Sbjct: 287 DALWTEKLQVLKQQYQTEMEKLREKCEQEK---ETLLKDKEIIFQAHIEEMNEKTLEKLD 343
Query: 1501 LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSF 1560
+ KQ LE ++ +E+ A E E+ L D+ ++ + A + + H
Sbjct: 344 V-KQT-----ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 397
Query: 1561 ASDTKQGRDEQLDNTMNKELLDAVPRAEL 1589
D+ E K L D + + EL
Sbjct: 398 QVDSIIKEHEVSIQRTEKALKDQINQLEL 426
Score = 58.4 bits (135), Expect = 2e-07
Identities = 102/573 (17%), Positives = 238/573 (41%), Gaps = 39/573 (6%)
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR----- 1066
N + L + K I ++++ ++ S++ Q TT+ E + E+ ++
Sbjct: 16 NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAA 75
Query: 1067 ---VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+ K L +++ E + L E D+QIK +++T +++ + + ++ M
Sbjct: 76 FEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK 135
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLETLN 1182
+ K QE + +Q R QEQ + Q Y KI Q +
Sbjct: 136 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 195
Query: 1183 TELTGHDVVNQEQ--INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
L ++ Q++ + + ++KL L E + + + EL SS+ ++ + + +L
Sbjct: 196 ESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL-A 254
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQ 1300
HL EA+ K E+ V + +++ E L Q + E +++ + T ++ KL+
Sbjct: 255 VHL---EAEKNKHNMEITVMVEKHKTELESLKHQ-QDALWTEKLQVLKQQYQTEME-KLR 309
Query: 1301 DKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK 1360
+K E + K ++I Q I E+ ++ + ++ +K
Sbjct: 310 EKCEQEKETLLKDKEIIFQAHI--EEMNEKTLEKLDVKQTELESLSSELSEVLKAR--HK 365
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKT 1420
+E S+L ++ ++K+ + D+ K E++ ++ + + +
Sbjct: 366 LEEELSVLK--DQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS--IQRTEKALKDQI 421
Query: 1421 HEYTITLTQRNDEFENVRQQLVEYE---KRIEDLTYEKESELAILRLKM---HENANHYE 1474
++ + L +R+ + + + E KR E + ++L + + HE YE
Sbjct: 422 NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE 481
Query: 1475 TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
++ +++++ KL++ TE + L KQVAE+ ++ + + + +++ ++
Sbjct: 482 --EQLAQLQQ-KLLD----LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 534
Query: 1535 TLNDEI-TNLQNMVRASSSKIQKHVSFASDTKQ 1566
N E+ ++++ + SK++ TKQ
Sbjct: 535 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 567
Score = 35.9 bits (79), Expect = 1.2
Identities = 57/324 (17%), Positives = 132/324 (40%), Gaps = 18/324 (5%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
+++ T +++ I +A ++ ++ L+ ++ K + SL + AR ++ E S L
Sbjct: 314 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 373
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIE--EKGSLEIANMTELTKKIELL 331
+ ++ +Q ++ +E + I+ EK + N EL LL
Sbjct: 374 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL-----LL 428
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM-KSPWSQLS 390
+ + +++ +EN A + + S K S +S + +K + +QL
Sbjct: 429 KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 488
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
+ L+ +T++ + ++A++E + + +L + I +D + + +
Sbjct: 489 QKLLDLETERILLTKQVAEVEAQKKDVCTEL--DAHKIQVQDLMQQLEKQNSEMEQKVKS 546
Query: 451 QLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEE 510
Q+ + +G E +I +E + ++ + K ++ L +KL + E+
Sbjct: 547 LTQVYESKLEDG------NKEQEQTKQILVEKENMILQMREGQKK-EIEILTQKLSAKED 599
Query: 511 QITQLNDEIDAANKNMIKVKSNHK 534
I LN+E + K K K K
Sbjct: 600 SIHILNEEYETKFKKKKKKKKKKK 623
>AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein.
Length = 742
Score = 105 bits (251), Expect = 2e-21
Identities = 145/672 (21%), Positives = 317/672 (47%), Gaps = 70/672 (10%)
Query: 471 NTEDVNEIA--KVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLNDEIDA----- 521
N E+V ++ +V + ++++ +K++ ++K LI++ E I +L++E D
Sbjct: 91 NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 150
Query: 522 -ANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
A+ + + +K + ++ + +++D+ +I RL +EL ++++ + ++E
Sbjct: 151 HASSSAQSPCGSPGMKRTESRQHLS--VELADAKAKIRRLRQELEEKTEQLLDCKQELEQ 208
Query: 581 LQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+++ L M + SD + + L R KA+ + + L E+ +++ +
Sbjct: 209 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK-----LESEVSRYKERLHD 263
Query: 640 VEDKLADISQLQSD-QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
+E A + +L+ D QV E K++ LE+Q++ A +L L+ + QL + D
Sbjct: 264 IEFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKL----HELEKENLQLKAKLHD 318
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL---LAKINHEEQSKIQTQFGIDA 755
+E +++ K++ ++ENM L + +K S ++ L L +I+ + Q +
Sbjct: 319 MEMERDMDRKKIEELMEENMTL-EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 377
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
++ E S L K + L +++ + S+E A ++ +E Q+ +
Sbjct: 378 EVNEL------TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 431
Query: 816 YTIQEDELVNRLAVL-----MDHDRVVEKQLLE--IEHENKELQKKNQILLEENQNLQIS 868
I E+E+V L + D + EK LE IE + +++ +IL +EN++L +
Sbjct: 432 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 491
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL------IVQKK 922
+S ++Q + + +A D+ E E+ +++ S L +I E + + +K
Sbjct: 492 VSSLRQR-SQISAEARVKDI-EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 549
Query: 923 KEIEDLEIEF-NTQIESAIRDKKVLN-----EKYEKNIEYVTQLEAQLQEYKNNIE---N 973
+ E+LE E + + E+ + KK+ N EK E + ++LE + ++ K ++ N
Sbjct: 550 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 609
Query: 974 LNMNVEELNKMNLELIDKHVQ-KQQTQSPDYTEQYINEINKLNALLKQKDEE-------I 1025
L +E L K N +L +++++ ++ +S + ++ N L+ + E+ +
Sbjct: 610 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 669
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
A +K +VSY + D E++ Q T LEN +++Q++ +L D + N+ LQ +
Sbjct: 670 KASFKKTERLEVSYQGL--DIENQRLQKT--LENSNKKIQQLESELQDLEMENQTLQKNL 725
Query: 1086 REQDDQIKELKE 1097
E K L++
Sbjct: 726 EELKISSKRLEQ 737
Score = 80.6 bits (190), Expect = 4e-14
Identities = 119/580 (20%), Positives = 245/580 (42%), Gaps = 44/580 (7%)
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+Q I+ ++ L+++ + E ++ I L E + ++ GS +
Sbjct: 107 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 166
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ ++ +++ + ++ L +QLL+ + E ++++ + + L +EN NL
Sbjct: 167 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 226
Query: 869 LSDMQQH---YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ + +AL EKA R D ESE ++Y+ +L D+E R V++ KE
Sbjct: 227 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR---------VEELKED 277
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL--NK 983
+ +E T +E + + ++K + + QL+A+L + + + +EEL
Sbjct: 278 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 337
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL-NQKINNAQVSYMSM 1042
M LE+ K + EQ A K E+ L + ++ ++ S+
Sbjct: 338 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 397
Query: 1043 VSDYE------SKLAQFTTKLENMEEEMQRVSK--QLLDSK--QHNEELQILVREQDDQI 1092
E + +K+ ME+E QR+SK ++L+++ Q + LQ D +
Sbjct: 398 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 457
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
KE + + T E +E I +E ++ N +V++ E +
Sbjct: 458 KEKAQLEKTIETLRENSERQI--KILEQENEHLNQTVSSLRQRSQISAEARVKDIE---K 512
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E +L E + +++L + + + EL H E+ +L+++L L EN+
Sbjct: 513 ENKILHESIKETSSKLSKIE---FEKRQIKKELE-HYKEKGERAEELENELHHLEKENEL 568
Query: 1213 LLSTVAELRSSIS--SAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
L + L+ + A++Q E+ E + L + F+ L QL + E + Q
Sbjct: 569 LQKKITNLKITCEKIEALEQENSEL-ERENRKLKKTLDSFK----NLTFQLESLEKENSQ 623
Query: 1271 L-LDSVQSSTQEETNKIVTMEQV-TSLQNK-LQDKEEHLR 1307
L ++++ E+ K +M+ L+NK L+ ++E L+
Sbjct: 624 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 663
Score = 80.6 bits (190), Expect = 4e-14
Identities = 126/585 (21%), Positives = 258/585 (44%), Gaps = 57/585 (9%)
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSK 746
++ L + D + + +L+ ++ +D +LE+M E ++ + + + +S
Sbjct: 171 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 230
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+ +DA ++E+ + ++ +ESE+S+YK R+ +E A +E E K D L
Sbjct: 231 RMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVE------ELKEDN--QVL 281
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
E + + ++L L + ++ +L ++E E +KK + L+EEN L+
Sbjct: 282 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 341
Query: 867 ISLS---DMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESN-LKRITHEHQTLI--V 919
++ D H +E+ +RT +L+E+ ++ +L S+ L ++ E+Q+L V
Sbjct: 342 MAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 401
Query: 920 QKKKEIEDLEIEFN-TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN--------- 969
++ + D +E N ++I ++ + L++K E + Q + LQ +N
Sbjct: 402 EELRTTVD-SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 460
Query: 970 -----NIENLNMNVEELNKMNLELIDKH----VQKQQTQSPDYTEQYINEINKLNALLKQ 1020
IE L N E K+ LE ++H V + +S E + +I K N +L +
Sbjct: 461 AQLEKTIETLRENSERQIKI-LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE 519
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
+E + KI + + Y+ K + +L ++E+E + + K++ + K
Sbjct: 520 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 579
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E+++ L +E + +E ++ K T + + + S E D N++
Sbjct: 580 CEKIEALEQENSELERENRKLKKTLD-SFKNLTFQLESLEKENSQLDEENLELRRNVESL 638
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ---- 1193
+K+ + + E L+ + +L L+ + E L G D+ NQ
Sbjct: 639 KCASMKMAQLQ---LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 695
Query: 1194 ------EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG 1232
++I QL+S+L+ L EN L + EL+ S S ++Q G
Sbjct: 696 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLG 739
Score = 66.5 bits (155), Expect = 7e-10
Identities = 128/573 (22%), Positives = 230/573 (40%), Gaps = 70/573 (12%)
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI-LVREQDDQIKELKETKLTFEMNIP 1107
+LA K+ + +E++ ++QLLD KQ E+++I L R Q + + L + +
Sbjct: 177 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR-------- 228
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-----EEEFIQERSVLQEQSA 1162
+ ++ + + A VD L E EE ++ VL E
Sbjct: 229 --SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 286
Query: 1163 KLNTELQECYT---KIIQLETLNTELTG--HDVVNQEQINQLKSKLEQLNTEN------- 1210
L +L+ K+ +LE N +L HD+ + ++ + K+E+L EN
Sbjct: 287 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD--RKKIEELMEENMTLEMAQ 344
Query: 1211 ----DNLLSTVAEL----RSSISSAVDQR--GFEIAELWKQHLAQREADFQ---KTEHEL 1257
D L EL R+S S Q+ G E+ EL L + E + Q KT EL
Sbjct: 345 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 404
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADV 1316
R + + E ++L ++ Q + K+ +E ++ + LQ+ + ++L ++ A +
Sbjct: 405 RTTVDSVEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 463
Query: 1317 INQIEILRSEIEDE-KVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILN--INE 1372
IE LR E + K+ + K ++ E IL+ I E
Sbjct: 464 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 523
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAE-AKVLELT-HQLELKDSEIYQK-------THEY 1423
+++L K E A+ LE H LE K++E+ QK T E
Sbjct: 524 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE-KENELLQKKITNLKITCEK 582
Query: 1424 TITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIE 1483
L Q N E E ++L + ++LT++ ES L+ + E ++ +E
Sbjct: 583 IEALEQENSELERENRKLKKTLDSFKNLTFQLES------LEKENSQLDEENLELRRNVE 636
Query: 1484 RVKLIEELNVKI-TESVSLNKQVAELNKALE---EEVAKTNEMQTALENQEIEIVTLNDE 1539
+K ++ E+ L + +L K LE KT ++ + + +IE L
Sbjct: 637 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 696
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
+ N ++ S++Q + + T Q E+L
Sbjct: 697 LENSNKKIQQLESELQ-DLEMENQTLQKNLEEL 728
Score = 56.8 bits (131), Expect = 6e-07
Identities = 104/511 (20%), Positives = 220/511 (43%), Gaps = 61/511 (11%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
+E+E K+RL DIE R+ L+E N++L LE + LE
Sbjct: 250 LESEVSRYKERL-HDIEFYKARVEELKEDNQVL--------LETKTM---LEDQLEGTRA 297
Query: 288 XXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELEN 347
L K++++ + ++E + ++ + EL ++ LE Q + L
Sbjct: 298 RSDKLHELEKENLQLKAKLH-DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW 356
Query: 348 KLATMGTESKAVSSPSKK-GSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDK-KINKN 405
+L + S+ +P K G + S R +M++ + E L D + N +
Sbjct: 357 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 416
Query: 406 EIAKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGP 463
+I K+E Q L+K ++++ E ++ EK + KD + + QLE
Sbjct: 417 KILKMEKENQRLSKKVEILENE-IVQEKQSLQNCQNLS---KDLMKEKAQLEKT------ 466
Query: 464 SLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE---KLKSAEEQITQLNDEID 520
+ T E+ K+ EQ + LN + + + I ++K E++ L++ I
Sbjct: 467 ----IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 522
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
+ + K++ + +Q++K ++++ + + +E L ELHHL ++ L+++ N
Sbjct: 523 ETSSKLSKIE----FEKRQIKKELEHYKEKGERAEE---LENELHHLEKENELLQKKITN 575
Query: 581 LQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA---ISLLESQKFDLVQELHILQQKY 637
L++ ++ S++ ++ +++ ++ + LE + L +E L++
Sbjct: 576 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 635
Query: 638 DEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL--------ALVIENLKLDK 689
+ ++ ++QLQ + E + L++ ++ L AS K+ L IEN +L K
Sbjct: 636 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 695
Query: 690 ---------EQLYGTIKDLENDKEDIMNKLQ 711
+QL ++DLE + + + L+
Sbjct: 696 TLENSNKKIQQLESELQDLEMENQTLQKNLE 726
Score = 43.2 bits (97), Expect = 0.008
Identities = 109/498 (21%), Positives = 197/498 (39%), Gaps = 53/498 (10%)
Query: 1142 LKVQEEEEFIQERSVLQ-EQSAKLNTELQEC---YTKIIQLETLN-TELTGHDVVNQEQI 1196
++ Q++EEFI+ L + A + +QE + L+ + T+++ D+ + +
Sbjct: 58 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDI--EPLL 115
Query: 1197 NQLKSKLEQLNTENDNLLSTVAELR-------------SSISSAVDQRGFEIAELWKQHL 1243
+ L++L E D T+ EL SS S G + E +QHL
Sbjct: 116 KNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTES-RQHL 174
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN-KIVTMEQVTSLQNKLQDK 1302
+ AD + LR +L E K EQLLD Q Q E K + E + L + +
Sbjct: 175 SVELADAKAKIRRLRQEL---EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 231
Query: 1303 --EEHLRNLQEKYADVIN-QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRT--ENQ 1357
+ L L+EK V + E+ R + + F + +T E+Q
Sbjct: 232 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 291
Query: 1358 -SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA--EAKVLELTHQLELKDS 1414
+ + + + +EN QLK ++ + E LE+ + + +S
Sbjct: 292 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 351
Query: 1415 -------EIYQKTHEYTITLTQR--NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
E +T E + + ++ E +L++ E + LT E EL
Sbjct: 352 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE-ELRTTVDS 410
Query: 1466 MHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNE-MQT 1524
+ NA+ M+KE++ K +E L +I + + L+K L +E A+ + ++T
Sbjct: 411 VEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 469
Query: 1525 ALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAV 1584
EN E +I L E +L V SS + + +S + K E NK L +++
Sbjct: 470 LRENSERQIKILEQENEHLNQTV--SSLRQRSQISAEARVKDIEKE------NKILHESI 521
Query: 1585 PRAELDLAMYMLHQRDVR 1602
L+ +R ++
Sbjct: 522 KETSSKLSKIEFEKRQIK 539
>AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 104 bits (249), Expect = 3e-21
Identities = 245/1449 (16%), Positives = 591/1449 (40%), Gaps = 111/1449 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDL---QEKINEKDQIIEAKNK--ATTXXX 197
DV L+ +KE + LQ+K+ ++ + + + ++++ ++ +++ ++N T
Sbjct: 144 DVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT 203
Query: 198 XXXXXXXXXXXXXXE--DTKQQMTKMQENFIAMEAEW---KDEKQRLLKDIESKDVRISS 252
E + K + +E +E + K + L K +E ++
Sbjct: 204 KTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE 263
Query: 253 LEEANKLLEAARFEISLE-HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
+E +E +F L H KL+ L + A + + +E E
Sbjct: 264 AKEQQASME-EKFHNELNAHIKLS-NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEAN 321
Query: 312 ---EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSP 368
+ LE+ + +K E+LE +I + KELEN + + + S++
Sbjct: 322 KAIQDHLLEVEQSKDQMEK-EMLE----KIGRLEKELENANDLLSATKRKGAILSEEELA 376
Query: 369 LISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+S + +K+ P +L +E N + + ++ + KLE + +NK L + +
Sbjct: 377 AMSPTAA--AVAKIVKPGMKL-TELYNAYVETQ-DQLLLEKLEN--KRINKYLDEIVKEV 430
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
K +A L ++ +Q M+ + + +T+ N+ + V E+ +
Sbjct: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMK--EIQRLQEDTDKANKQSSVLERDNRR 488
Query: 489 LNDEIKDVN--VKDLIEKLKSAEEQITQLNDEIDAAN-KNMIKVKSNHKLKLKQMQKTID 545
+ ++KD++ ++ L+ +L+ A ++E+ +A+ + +V S H + + +++
Sbjct: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
Query: 546 NFSKVSDSNKEI--VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
++ + +E+ R EE S K+ EL+ + + L R + + ++
Sbjct: 549 QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH 663
++ +L SQ + LH + S Q+ + + +
Sbjct: 609 RQRDM-------YRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK-EDIMNKLQNYIQENMDLTD 722
E I+A A+ K+L + EN K +K + + ++N++ E + ++ + +N ++
Sbjct: 662 STEAIEA-KAALKQLQEIFENYKKEKAE----NEKIQNEQLEKLQEQVTDLRSQNTKIST 716
Query: 723 KLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+L+ S E + + + E S + + A Q+++ I + +L
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR-------G 769
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E +AV E R +L+++ + L L E + + ++ ++ L L+ + + ++
Sbjct: 770 ANEKLAVAEVRAENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNL--LLTNLQTIQGI 825
Query: 841 LLEIEHENKE-LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
L E E K+ L + + L E +L+ L + + + L + L +T
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTET- 884
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN-EKYEKNIEYVT 958
+L N K + Q I K+ + ++E++ +Q + N E + + +
Sbjct: 885 --NLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E Q+ + K ++ NVE+ M + +++ + K++ + + + + +
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAM-VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
Q +++++ + ++ Q + E +L++ L +++ E+Q ++ + +
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
++ + R+ +Q K E + +E + M+ ++ +E + V
Sbjct: 1062 QQAR---RDCQEQAKIAVEAQNKYEREL-----MLHAADVEALQAAKEQVSKMASVRQHL 1113
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQEQIN 1197
+ + E + ++ ++ +E+ L E+ +C + LE N L + ++ + +
Sbjct: 1114 EETTQ-KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
Query: 1198 QLKSKLE-QLN---TENDNLLSTVAELRSSI--SSAVDQRGFEIAEL----WKQHLAQRE 1247
+K ++ LN +E + E+ I + + FE+A++ ++Q + E
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1248 ADFQKTEHEL-----RVQLSA-FESKYEQLLDSVQS-STQEETNKIVTMEQ------VTS 1294
+ Q+ + L +VQ++A +++E+L+ ++ + ETNK++ E+ +
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSE---IEDEKVAFXXXXXXXXXXXXXXXXD 1351
+Q K++ E + LQE A++ + +L++E +E++ + +
Sbjct: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
+ S K++ + I + EE +LK + + + ++ + E
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
++ K I + ++ V++ Y+ + E+L +++ ++ + +
Sbjct: 1413 IQKDLDAK----IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDK---VMETSAQSSGD 1465
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
H E E++ +K E LN T+S SL QV L K L E+ + +Q +
Sbjct: 1466 HQEQHVSVQEMQELK--ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
Query: 1532 EIVTLNDEI 1540
E+ L ++
Sbjct: 1524 ELSRLRQDL 1532
Score = 102 bits (244), Expect = 1e-20
Identities = 225/1182 (19%), Positives = 491/1182 (41%), Gaps = 87/1182 (7%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNN 970
+ L+++ +E + + ++ SA +V+++ +NIE + Q +L
Sbjct: 501 RVLLME-LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
Query: 971 I-ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
+ E +E + + ++ T+ + +++ ++++++Q+D I L+
Sbjct: 560 LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
Q A + S + D LA + + +++S + E L
Sbjct: 620 QTTGVAIPLHASSLDDV--SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL----- 672
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD-DANNVDXXXXXXXXXXXXLKVQEE- 1147
Q++E+ E + K + + E ++D + N +Q+
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLN 1207
E + +E + L E++ KL Q+ +II T+ +L G + E++ + + E L
Sbjct: 733 EGYRREITSLHERNQKLTATTQK-QEQII--NTMTQDLRGAN----EKLAVAEVRAENLK 785
Query: 1208 TENDNL-LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
E + L LS V + S +QRG L +L + +++E E + +LS+
Sbjct: 786 KEKEMLKLSEVRLSQQRESLLAEQRG---QNLLLTNLQTIQGILERSETETKQRLSSQIE 842
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQ---VTSLQNKLQ-DKEEHLR-NLQEKYADVINQIE 1321
K E + ++ + E + T+ + V L K Q D E +L N +E + +I
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXX-XXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
L+ + + +V D+ +Q +EQ +N+ +LK S
Sbjct: 903 TLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ----VNDLKERLKTS 958
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE-NVRQ 1439
+ V +A V L L K+ ++ ++ + + + EF+ + +
Sbjct: 959 T-----------SNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
+L+E EK ++L +K + + ++ E ++Q E + + ++ + ++
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNEQ 1062
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIE-IVTLNDEITNLQNMVRASSSKIQKHV 1558
+ E K + E E + L ++E + ++++ + ++ + QK
Sbjct: 1063 QARRDCQEQAK-IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
Query: 1559 SFASDTKQGRDEQLDNTMNKELLDAVPRAE-LDLAMYMLHQR 1599
S + K +E+ + + E+ V R E L+ +LH +
Sbjct: 1122 SQLLECKASWEER-ERMLKDEVSKCVCRCEDLEKQNRLLHDQ 1162
Score = 101 bits (241), Expect = 3e-20
Identities = 174/918 (18%), Positives = 395/918 (43%), Gaps = 91/918 (9%)
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEI 519
+E I + + EI + ++ K E N++I++ ++ L E++ Q T+++ ++
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAE-NEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 520 DAANKNMIKVKSN---HKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELE 575
D A+K ++ N ++ ++ + + + + ++I+ +T++L ++K+A E
Sbjct: 719 DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
Query: 576 EEKGNLQ-----LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-LLESQKFDLVQE 629
NL+ L L + + ES + ++ +NL T L+ I +LE + + Q
Sbjct: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQR 836
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLD 688
L ++E +IS L+ ++ +E++ H L +D K NL L+
Sbjct: 837 LS------SQIEKLEHEISHLKK-KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLN 889
Query: 689 -KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
KE L K++ K+ + N ++ T K + + E + +L++++ E+
Sbjct: 890 TKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI----AVMEDRRYSLERKADQLG 803
++ER ++ S + +Y++ + LEES+ V E+ R ++E + +
Sbjct: 950 D--------LKER---LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 804 SYLQEKQKAYSEYTIQEDELVN--RLAVLMDHDRVVE--KQLLEIEHENKE-LQKKNQIL 858
+ + +K E ++ EL + R A+ ++ E K L +++E +E LQ+ + L
Sbjct: 999 EFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
Query: 859 LEENQNLQISLSDMQQHYNALVEKANR---------TDLAESESTKYQ-TQLRDLESNLK 908
E Q + D Q+ VE N+ D+ ++ K Q +++ + +L+
Sbjct: 1059 SNEQQ----ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAI---RDKKVLNEKYEKNIEYVTQLEAQLQ 965
T + ++ +++ K E+ E ++ + D + N IE ++ + +
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS--DKVVA 1172
Query: 966 EYKNNIEN-LNMNVEELNKMNLELID--KHVQKQQTQSPDYTE----QYINEINKLNALL 1018
K ++ LN+++ E K ++++ + +++++ + E + + ++ L
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++ E +LN + QV+ +M E T + +M R K+ L+ Q
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE--QDL 1290
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+++Q VR+ + I L+E + + GM+ + + + +D
Sbjct: 1291 QQMQAKVRKLELDILPLQEANA----ELSEKSGMLQAEK-KLLEEDVKRWKARNQHLVSQ 1345
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
+E + + E+ V ++ +L E+ +I + N LT NQ I
Sbjct: 1346 QKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARS---NASLTN----NQNLIQS 1398
Query: 1199 LKSKLEQLNTEND----NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
LK L ++ TE + +L + + +++ + + + +I +K + +A K
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK--KIGRRYKTQYEELKAQQDKVM 1456
Query: 1255 HELRVQLSAFESKY---EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
+ ++ +++ + ++ Q ET QV +LQ L +KE RNLQE
Sbjct: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
Query: 1312 KYADVINQIEILRSEIED 1329
+ + +++ LR +++D
Sbjct: 1517 QTVQLQSELSRLRQDLQD 1534
Score = 96.7 bits (230), Expect = 6e-19
Identities = 224/1051 (21%), Positives = 450/1051 (42%), Gaps = 144/1051 (13%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLAQELEQXXXXXX 286
++ E ++ Q + D+ S++ +IS+ L+ A+K E + + ++ E+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
+Q I ++ EK ++ L K+ E+L+ ++ Q + L
Sbjct: 752 TTQKQ-----EQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLL 806
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
+ G + + +G I +S T ++ S +L E + KK +NE
Sbjct: 807 AE--QRGQNLLLTNLQTIQG---ILERSETETKQRLSSQIEKLEHEISHL---KKKLENE 858
Query: 407 IAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
+ + + ++L+ L+D + + + IA L+ +H +ME
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLK-QHLSNME----- 912
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
V ++ K Q K++ V DL+ +L+ EEQ+ L + + + N+
Sbjct: 913 -VQVASQSSQRTGKGQPSNKED---------VDDLVSQLRQTEEQVNDLKERLKTSTSNV 962
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEI-VRLTEELH---HLSQKVAELEEEKGNL 581
++ + ++++++ +V++ K I VRL E L +K+ E+E+EK L
Sbjct: 963 ----EQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Query: 582 QLHLVDYDSGRMIES------DVYKKMIEMENLAETRLK----AISLLESQKFDLVQELH 631
Q D R IES ++ K + ++N + L+ A+S + + D ++
Sbjct: 1019 Q-----DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK 1073
Query: 632 IL---QQKYD-EVEDKLADISQLQS--DQVCSEIKSV--HLEEQIDALSASKKELALVIE 683
I Q KY+ E+ AD+ LQ+ +QV S++ SV HLEE + K E L+
Sbjct: 1074 IAVEAQNKYERELMLHAADVEALQAAKEQV-SKMASVRQHLEE-----TTQKAESQLL-- 1125
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
K E+ +KD + + + ++ ++N L D++EK+S +++A +
Sbjct: 1126 ECKASWEERERMLKD---EVSKCVCRCEDLEKQNRLLHDQIEKLS----DKVVASVKEGV 1178
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
Q + + K QE+ L I + + I +A +E RY ++ + L
Sbjct: 1179 QGPLNVSLSEEGKSQEQILEI----LRFIRREKEIAETRFEVAQVESLRY--RQRVELLE 1232
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLM-DHDRVVEK-QLLEIEHE-NKELQKKNQILLE 860
LQE Q + + E E V A M H+ +++K + + + E NK L+++ + L +
Sbjct: 1233 RELQELQDSLNA----EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQ 1288
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ Q +Q + ++ L E AN +L+E +S Q + + LE ++KR +Q L+ Q
Sbjct: 1289 DLQQMQAKVRKLELDILPLQE-AN-AELSE-KSGMLQAEKKLLEEDVKRWKARNQHLVSQ 1345
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
+K D E E+ +K+L+EK E + + + QL ++ K I N ++
Sbjct: 1346 QKDP--DTE-EY----------RKLLSEK-EVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYM 1040
N+ ++ + + + K +T+ + K D +II + +K+
Sbjct: 1392 -NQNLIQSLKEDLNKVRTEK--------------ETIQKDLDAKIIDIQEKVKT------ 1430
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKL 1100
++ + ++ T+ E ++ + +V + S ++E + V+E ++ELKET
Sbjct: 1431 --ITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE----MQELKETLN 1484
Query: 1101 TFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
E E + + T+ +A N+ L+ + +Q+R+ +
Sbjct: 1485 QAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLR-----QDLQDRTTQE 1539
Query: 1159 EQSAKLNTELQECYTK-IIQLETLNTELTG-HDVVNQEQINQLKSKLEQLNTENDNLLST 1216
EQ + TE +E K I+ ++ L G D + +E +LK + L+ + D L
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN-EELKQRNGALDQQKDELDVR 1598
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+ L+S + + E+ E ++HL QR+
Sbjct: 1599 ITALKSQYEGRISRLERELREHQERHLEQRD 1629
Score = 93.9 bits (223), Expect = 4e-18
Identities = 168/935 (17%), Positives = 393/935 (42%), Gaps = 80/935 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
T +S + +LQ ++ I L E+ N+K K +
Sbjct: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMTQDLRGA 770
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + + K +E E +++ LL + +++ +++L+ +LE +
Sbjct: 771 NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830
Query: 265 FE----ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
E +S + KL E+ L + + K +++ + +L + N
Sbjct: 831 TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL-N 889
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS--PLISR-----K 373
EL K + + + ++Q +E ++A+ ++ PS K L+S+ +
Sbjct: 890 TKELLKNAQ--KEI-ATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 374 SGRNTASKMKSPWSQLSS---------ETLNQDTD--KKINKNEIAKLEMVIQ---SLNK 419
+ ++K+ S + E+LN++ +++ KN +L+ + L K
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 420 DLVD----KEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS--LIHVGTNTE 473
L++ K+ + +K ++ +Q E Q+ ++ S L +
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR 1066
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQ-------LNDEIDAANKNM 526
D E AK+ + + + E+ ++ D +E L++A+EQ+++ L + A +
Sbjct: 1067 DCQEQAKIAVEAQNKYERELM-LHAAD-VEALQAAKEQVSKMASVRQHLEETTQKAESQL 1124
Query: 527 IKVKSNHKLKLKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQKVAELEEE--KGNLQL 583
++ K++ + + + ++ + + D K+ L +++ LS KV +E +G L +
Sbjct: 1125 LECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
Query: 584 HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
L + + ++ + + + +AETR + ++ +ES ++ Q + +L+++ E++D
Sbjct: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFE-VAQVESLRYR--QRVELLERELQELQDS 1241
Query: 644 LADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L ++ + QV ++ + H E E ++ + + K L E L+ D +Q+ ++
Sbjct: 1242 LN--AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRK 1299
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAK 756
LE D + LQ + N +L++K + AEK + E + + Q + Q D +
Sbjct: 1300 LELD----ILPLQ---EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 757 -----IQERDLY---IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+ E++++ I+ + E+ + K+ I R S+ ++ SL+ +++ + +
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
QK I E V + + R + Q E++ + ++ + + ++Q +S
Sbjct: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ +MQ+ L + ++ ES+ Q L + E+ + + + QT+ +Q +
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNL--QEQTVQLQSELSRLRQ 1530
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+++ T E +R + + EK EK + + ++++ + L EEL + N
Sbjct: 1531 DLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-GA 1587
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+D+ + + QY I++L L++ E
Sbjct: 1588 LDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 66.1 bits (154), Expect = 1e-09
Identities = 138/767 (17%), Positives = 310/767 (40%), Gaps = 64/767 (8%)
Query: 98 LKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNA 157
L KE+L K+ L + S V+ DV L + +++ +
Sbjct: 888 LNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
Query: 158 LSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQ 217
++ L+ ++K + + Q + ++ + + + T +++
Sbjct: 948 VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKK 1007
Query: 218 MTKMQENFIAMEAEWKDEKQRLLKDIESK----DVRISSLE-EANKLLEAARFEISLEHS 272
+ ++++ + E +D+K+R ++ +E + +SS++ E + L+ A +S E
Sbjct: 1008 LMEVEKE----KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 273 --KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
+ QE + L +E K ++ + S+ ++ E T+K E
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR-QHLEETTQKAES 1122
Query: 331 LEHLNCQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK---MKSP 385
+ L C+ +E L+++++ + + ++ I + S + AS ++ P
Sbjct: 1123 -QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
Query: 386 WS-QLSSETLNQDTDKKI-----NKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+ LS E +Q+ +I + EIA+ + + + + E++
Sbjct: 1182 LNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDS 1241
Query: 440 XXXXGKDTLI-AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
+ + A+ +H++ M+ ++V T + + + +E+L+Q+L V
Sbjct: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM--LREEKERLEQDLQQMQAKVRK 1299
Query: 499 KDL-IEKLKSAEEQITQLNDEIDAANKNMIK-VKS----NHKLKLKQMQKTIDNFSKVSD 552
+L I L+ A ++++ + + A K + + VK N L +Q + + K+
Sbjct: 1300 LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLS 1359
Query: 553 SN----KEIVRLTEELHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM------IESDVYK 600
K I +LTEE+ L ++A N Q + + D ++ I+ D+
Sbjct: 1360 EKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDA 1419
Query: 601 KMIEMENLAET--RLKAISL--------LESQKFDLVQELHILQQKYDEVEDKLADISQL 650
K+I+++ +T ++K I L++Q+ +++ + E + ++ +L
Sbjct: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK- 709
+ +E KS LE Q++ L + E NL+ QL + L D +D +
Sbjct: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
Query: 710 --LQNYIQENMDLTDKLEKMSAEKISELLA---KINHEEQSKIQTQFGIDAKIQERDLYI 764
L+ I E + T K + KI+ L ++ E + Q +D + E D+ I
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
++S+ Y+ RI RLE + ++R + + + + E+Q+
Sbjct: 1600 TALKSQ---YEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 122/647 (18%), Positives = 256/647 (39%), Gaps = 39/647 (6%)
Query: 91 SESLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT 150
S L++K + +EK KQ + KR + + ++ + ++T
Sbjct: 997 SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
Query: 151 -IKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXX 209
+ + A Q + KI ++ Q K E++ ++ A +
Sbjct: 1057 ALSNEQQARRDCQEQAKIA----VEAQNKY-ERELMLHAADVEALQAAKEQVSKMASVRQ 1111
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDV-RISSLEEANKLLEAARFEIS 268
E+T Q K + + +A W +E++R+LKD SK V R LE+ N+LL ++S
Sbjct: 1112 HLEETTQ---KAESQLLECKASW-EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL--TK 326
+ +E Q I + EI E E+A + L +
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET-RFEVAQVESLRYRQ 1226
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
++ELLE + +EL++ L + + + + L+ + N +
Sbjct: 1227 RVELLE-------RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 387 SQLSSETLNQDTDKKINKNEIAKLEMV-IQSLNKDLVDKEYVI-SEKDTXXXXXXXXXXG 444
+ E L QD + K +L+++ +Q N +L +K ++ +EK
Sbjct: 1280 RE-EKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
Query: 445 KDTLIAQLQ---LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE----LNDEIKDVN 497
L++Q + E + + +H + EI +++ ++ + N++ +
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 498 VKDLIEKLKSAEEQITQLND----EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+K+ + K+++ +E I + D +I K + +VK + Q ++ KV ++
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETR 612
+ + +E H Q++ EL+E + +S ++ + +K E NL E
Sbjct: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
++ S L + DL +Q ++ +K + + V ++ K HL D L+
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEK---EEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
+EL L K++L I L++ E +++L+ ++E+ +
Sbjct: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
>AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 104 bits (249), Expect = 3e-21
Identities = 245/1449 (16%), Positives = 591/1449 (40%), Gaps = 111/1449 (7%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDL---QEKINEKDQIIEAKNK--ATTXXX 197
DV L+ +KE + LQ+K+ ++ + + + ++++ ++ +++ ++N T
Sbjct: 144 DVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT 203
Query: 198 XXXXXXXXXXXXXXE--DTKQQMTKMQENFIAMEAEW---KDEKQRLLKDIESKDVRISS 252
E + K + +E +E + K + L K +E ++
Sbjct: 204 KTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE 263
Query: 253 LEEANKLLEAARFEISLE-HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
+E +E +F L H KL+ L + A + + +E E
Sbjct: 264 AKEQQASME-EKFHNELNAHIKLS-NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEAN 321
Query: 312 ---EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSP 368
+ LE+ + +K E+LE +I + KELEN + + + S++
Sbjct: 322 KAIQDHLLEVEQSKDQMEK-EMLE----KIGRLEKELENANDLLSATKRKGAILSEEELA 376
Query: 369 LISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+S + +K+ P +L +E N + + ++ + KLE + +NK L + +
Sbjct: 377 AMSPTAA--AVAKIVKPGMKL-TELYNAYVETQ-DQLLLEKLEN--KRINKYLDEIVKEV 430
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
K +A L ++ +Q M+ + + +T+ N+ + V E+ +
Sbjct: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMK--EIQRLQEDTDKANKQSSVLERDNRR 488
Query: 489 LNDEIKDVN--VKDLIEKLKSAEEQITQLNDEIDAAN-KNMIKVKSNHKLKLKQMQKTID 545
+ ++KD++ ++ L+ +L+ A ++E+ +A+ + +V S H + + +++
Sbjct: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
Query: 546 NFSKVSDSNKEI--VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
++ + +E+ R EE S K+ EL+ + + L R + + ++
Sbjct: 549 QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH 663
++ +L SQ + LH + S Q+ + + +
Sbjct: 609 RQRDM-------YRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK-EDIMNKLQNYIQENMDLTD 722
E I+A A+ K+L + EN K +K + + ++N++ E + ++ + +N ++
Sbjct: 662 STEAIEA-KAALKQLQEIFENYKKEKAE----NEKIQNEQLEKLQEQVTDLRSQNTKIST 716
Query: 723 KLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+L+ S E + + + E S + + A Q+++ I + +L
Sbjct: 717 QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR-------G 769
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E +AV E R +L+++ + L L E + + ++ ++ L L+ + + ++
Sbjct: 770 ANEKLAVAEVRAENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNL--LLTNLQTIQGI 825
Query: 841 LLEIEHENKE-LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
L E E K+ L + + L E +L+ L + + + L + L +T
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTET- 884
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN-EKYEKNIEYVT 958
+L N K + Q I K+ + ++E++ +Q + N E + + +
Sbjct: 885 --NLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E Q+ + K ++ NVE+ M + +++ + K++ + + + + +
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAM-VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
Q +++++ + ++ Q + E +L++ L +++ E+Q ++ + +
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
++ + R+ +Q K E + +E + M+ ++ +E + V
Sbjct: 1062 QQAR---RDCQEQAKIAVEAQNKYEREL-----MLHAADVEALQAAKEQVSKMASVRQHL 1113
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQEQIN 1197
+ + E + ++ ++ +E+ L E+ +C + LE N L + ++ + +
Sbjct: 1114 EETTQ-KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
Query: 1198 QLKSKLE-QLN---TENDNLLSTVAELRSSI--SSAVDQRGFEIAEL----WKQHLAQRE 1247
+K ++ LN +E + E+ I + + FE+A++ ++Q + E
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1248 ADFQKTEHEL-----RVQLSA-FESKYEQLLDSVQS-STQEETNKIVTMEQ------VTS 1294
+ Q+ + L +VQ++A +++E+L+ ++ + ETNK++ E+ +
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSE---IEDEKVAFXXXXXXXXXXXXXXXXD 1351
+Q K++ E + LQE A++ + +L++E +E++ + +
Sbjct: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
+ S K++ + I + EE +LK + + + ++ + E
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
++ K I + ++ V++ Y+ + E+L +++ ++ + +
Sbjct: 1413 IQKDLDAK----IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDK---VMETSAQSSGD 1465
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
H E E++ +K E LN T+S SL QV L K L E+ + +Q +
Sbjct: 1466 HQEQHVSVQEMQELK--ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
Query: 1532 EIVTLNDEI 1540
E+ L ++
Sbjct: 1524 ELSRLRQDL 1532
Score = 102 bits (244), Expect = 1e-20
Identities = 225/1182 (19%), Positives = 491/1182 (41%), Gaps = 87/1182 (7%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNN 970
+ L+++ +E + + ++ SA +V+++ +NIE + Q +L
Sbjct: 501 RVLLME-LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
Query: 971 I-ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
+ E +E + + ++ T+ + +++ ++++++Q+D I L+
Sbjct: 560 LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
Q A + S + D LA + + +++S + E L
Sbjct: 620 QTTGVAIPLHASSLDDV--SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL----- 672
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD-DANNVDXXXXXXXXXXXXLKVQEE- 1147
Q++E+ E + K + + E ++D + N +Q+
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLN 1207
E + +E + L E++ KL Q+ +II T+ +L G + E++ + + E L
Sbjct: 733 EGYRREITSLHERNQKLTATTQK-QEQII--NTMTQDLRGAN----EKLAVAEVRAENLK 785
Query: 1208 TENDNL-LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
E + L LS V + S +QRG L +L + +++E E + +LS+
Sbjct: 786 KEKEMLKLSEVRLSQQRESLLAEQRG---QNLLLTNLQTIQGILERSETETKQRLSSQIE 842
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQ---VTSLQNKLQ-DKEEHLR-NLQEKYADVINQIE 1321
K E + ++ + E + T+ + V L K Q D E +L N +E + +I
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXX-XXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
L+ + + +V D+ +Q +EQ +N+ +LK S
Sbjct: 903 TLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ----VNDLKERLKTS 958
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE-NVRQ 1439
+ V +A V L L K+ ++ ++ + + + EF+ + +
Sbjct: 959 T-----------SNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
+L+E EK ++L +K + + ++ E ++Q E + + ++ + ++
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNEQ 1062
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIE-IVTLNDEITNLQNMVRASSSKIQKHV 1558
+ E K + E E + L ++E + ++++ + ++ + QK
Sbjct: 1063 QARRDCQEQAK-IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
Query: 1559 SFASDTKQGRDEQLDNTMNKELLDAVPRAE-LDLAMYMLHQR 1599
S + K +E+ + + E+ V R E L+ +LH +
Sbjct: 1122 SQLLECKASWEER-ERMLKDEVSKCVCRCEDLEKQNRLLHDQ 1162
Score = 101 bits (241), Expect = 3e-20
Identities = 174/918 (18%), Positives = 395/918 (43%), Gaps = 91/918 (9%)
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEI 519
+E I + + EI + ++ K E N++I++ ++ L E++ Q T+++ ++
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAE-NEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 520 DAANKNMIKVKSN---HKLKLKQMQKTIDNFSKVSDSNKEIVR-LTEELHHLSQKVAELE 575
D A+K ++ N ++ ++ + + + + ++I+ +T++L ++K+A E
Sbjct: 719 DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
Query: 576 EEKGNLQ-----LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-LLESQKFDLVQE 629
NL+ L L + + ES + ++ +NL T L+ I +LE + + Q
Sbjct: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQR 836
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLD 688
L ++E +IS L+ ++ +E++ H L +D K NL L+
Sbjct: 837 LS------SQIEKLEHEISHLKK-KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLN 889
Query: 689 -KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
KE L K++ K+ + N ++ T K + + E + +L++++ E+
Sbjct: 890 TKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI----AVMEDRRYSLERKADQLG 803
++ER ++ S + +Y++ + LEES+ V E+ R ++E + +
Sbjct: 950 D--------LKER---LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 804 SYLQEKQKAYSEYTIQEDELVN--RLAVLMDHDRVVE--KQLLEIEHENKE-LQKKNQIL 858
+ + +K E ++ EL + R A+ ++ E K L +++E +E LQ+ + L
Sbjct: 999 EFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
Query: 859 LEENQNLQISLSDMQQHYNALVEKANR---------TDLAESESTKYQ-TQLRDLESNLK 908
E Q + D Q+ VE N+ D+ ++ K Q +++ + +L+
Sbjct: 1059 SNEQQ----ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAI---RDKKVLNEKYEKNIEYVTQLEAQLQ 965
T + ++ +++ K E+ E ++ + D + N IE ++ + +
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS--DKVVA 1172
Query: 966 EYKNNIEN-LNMNVEELNKMNLELID--KHVQKQQTQSPDYTE----QYINEINKLNALL 1018
K ++ LN+++ E K ++++ + +++++ + E + + ++ L
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++ E +LN + QV+ +M E T + +M R K+ L+ Q
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE--QDL 1290
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+++Q VR+ + I L+E + + GM+ + + + +D
Sbjct: 1291 QQMQAKVRKLELDILPLQEANA----ELSEKSGMLQAEK-KLLEEDVKRWKARNQHLVSQ 1345
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
+E + + E+ V ++ +L E+ +I + N LT NQ I
Sbjct: 1346 QKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARS---NASLTN----NQNLIQS 1398
Query: 1199 LKSKLEQLNTEND----NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
LK L ++ TE + +L + + +++ + + + +I +K + +A K
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK--KIGRRYKTQYEELKAQQDKVM 1456
Query: 1255 HELRVQLSAFESKY---EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE 1311
+ ++ +++ + ++ Q ET QV +LQ L +KE RNLQE
Sbjct: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
Query: 1312 KYADVINQIEILRSEIED 1329
+ + +++ LR +++D
Sbjct: 1517 QTVQLQSELSRLRQDLQD 1534
Score = 96.7 bits (230), Expect = 6e-19
Identities = 224/1051 (21%), Positives = 450/1051 (42%), Gaps = 144/1051 (13%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLAQELEQXXXXXX 286
++ E ++ Q + D+ S++ +IS+ L+ A+K E + + ++ E+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
+Q I ++ EK ++ L K+ E+L+ ++ Q + L
Sbjct: 752 TTQKQ-----EQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLL 806
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
+ G + + +G I +S T ++ S +L E + KK +NE
Sbjct: 807 AE--QRGQNLLLTNLQTIQG---ILERSETETKQRLSSQIEKLEHEISHL---KKKLENE 858
Query: 407 IAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
+ + + ++L+ L+D + + + IA L+ +H +ME
Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLK-QHLSNME----- 912
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
V ++ K Q K++ V DL+ +L+ EEQ+ L + + + N+
Sbjct: 913 -VQVASQSSQRTGKGQPSNKED---------VDDLVSQLRQTEEQVNDLKERLKTSTSNV 962
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEI-VRLTEELH---HLSQKVAELEEEKGNL 581
++ + ++++++ +V++ K I VRL E L +K+ E+E+EK L
Sbjct: 963 ----EQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Query: 582 QLHLVDYDSGRMIES------DVYKKMIEMENLAETRLK----AISLLESQKFDLVQELH 631
Q D R IES ++ K + ++N + L+ A+S + + D ++
Sbjct: 1019 Q-----DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK 1073
Query: 632 IL---QQKYD-EVEDKLADISQLQS--DQVCSEIKSV--HLEEQIDALSASKKELALVIE 683
I Q KY+ E+ AD+ LQ+ +QV S++ SV HLEE + K E L+
Sbjct: 1074 IAVEAQNKYERELMLHAADVEALQAAKEQV-SKMASVRQHLEE-----TTQKAESQLL-- 1125
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
K E+ +KD + + + ++ ++N L D++EK+S +++A +
Sbjct: 1126 ECKASWEERERMLKD---EVSKCVCRCEDLEKQNRLLHDQIEKLS----DKVVASVKEGV 1178
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
Q + + K QE+ L I + + I +A +E RY ++ + L
Sbjct: 1179 QGPLNVSLSEEGKSQEQILEI----LRFIRREKEIAETRFEVAQVESLRY--RQRVELLE 1232
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLM-DHDRVVEK-QLLEIEHE-NKELQKKNQILLE 860
LQE Q + + E E V A M H+ +++K + + + E NK L+++ + L +
Sbjct: 1233 RELQELQDSLNA----EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQ 1288
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ Q +Q + ++ L E AN +L+E +S Q + + LE ++KR +Q L+ Q
Sbjct: 1289 DLQQMQAKVRKLELDILPLQE-AN-AELSE-KSGMLQAEKKLLEEDVKRWKARNQHLVSQ 1345
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
+K D E E+ +K+L+EK E + + + QL ++ K I N ++
Sbjct: 1346 QKDP--DTE-EY----------RKLLSEK-EVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYM 1040
N+ ++ + + + K +T+ + K D +II + +K+
Sbjct: 1392 -NQNLIQSLKEDLNKVRTEK--------------ETIQKDLDAKIIDIQEKVKT------ 1430
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKL 1100
++ + ++ T+ E ++ + +V + S ++E + V+E ++ELKET
Sbjct: 1431 --ITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE----MQELKETLN 1484
Query: 1101 TFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
E E + + T+ +A N+ L+ + +Q+R+ +
Sbjct: 1485 QAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLR-----QDLQDRTTQE 1539
Query: 1159 EQSAKLNTELQECYTK-IIQLETLNTELTG-HDVVNQEQINQLKSKLEQLNTENDNLLST 1216
EQ + TE +E K I+ ++ L G D + +E +LK + L+ + D L
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN-EELKQRNGALDQQKDELDVR 1598
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+ L+S + + E+ E ++HL QR+
Sbjct: 1599 ITALKSQYEGRISRLERELREHQERHLEQRD 1629
Score = 93.9 bits (223), Expect = 4e-18
Identities = 168/935 (17%), Positives = 393/935 (42%), Gaps = 80/935 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
T +S + +LQ ++ I L E+ N+K K +
Sbjct: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMTQDLRGA 770
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + + K +E E +++ LL + +++ +++L+ +LE +
Sbjct: 771 NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830
Query: 265 FE----ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
E +S + KL E+ L + + K +++ + +L + N
Sbjct: 831 TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL-N 889
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS--PLISR-----K 373
EL K + + + ++Q +E ++A+ ++ PS K L+S+ +
Sbjct: 890 TKELLKNAQ--KEI-ATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 374 SGRNTASKMKSPWSQLSS---------ETLNQDTD--KKINKNEIAKLEMVIQ---SLNK 419
+ ++K+ S + E+LN++ +++ KN +L+ + L K
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 420 DLVD----KEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS--LIHVGTNTE 473
L++ K+ + +K ++ +Q E Q+ ++ S L +
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR 1066
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQ-------LNDEIDAANKNM 526
D E AK+ + + + E+ ++ D +E L++A+EQ+++ L + A +
Sbjct: 1067 DCQEQAKIAVEAQNKYERELM-LHAAD-VEALQAAKEQVSKMASVRQHLEETTQKAESQL 1124
Query: 527 IKVKSNHKLKLKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQKVAELEEE--KGNLQL 583
++ K++ + + + ++ + + D K+ L +++ LS KV +E +G L +
Sbjct: 1125 LECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
Query: 584 HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
L + + ++ + + + +AETR + ++ +ES ++ Q + +L+++ E++D
Sbjct: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFE-VAQVESLRYR--QRVELLERELQELQDS 1241
Query: 644 LADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L ++ + QV ++ + H E E ++ + + K L E L+ D +Q+ ++
Sbjct: 1242 LN--AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRK 1299
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAK 756
LE D + LQ + N +L++K + AEK + E + + Q + Q D +
Sbjct: 1300 LELD----ILPLQ---EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 757 -----IQERDLY---IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+ E++++ I+ + E+ + K+ I R S+ ++ SL+ +++ + +
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
QK I E V + + R + Q E++ + ++ + + ++Q +S
Sbjct: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ +MQ+ L + ++ ES+ Q L + E+ + + + QT+ +Q +
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNL--QEQTVQLQSELSRLRQ 1530
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+++ T E +R + + EK EK + + ++++ + L EEL + N
Sbjct: 1531 DLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-GA 1587
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+D+ + + QY I++L L++ E
Sbjct: 1588 LDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 66.1 bits (154), Expect = 1e-09
Identities = 138/767 (17%), Positives = 310/767 (40%), Gaps = 64/767 (8%)
Query: 98 LKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNA 157
L KE+L K+ L + S V+ DV L + +++ +
Sbjct: 888 LNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
Query: 158 LSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQ 217
++ L+ ++K + + Q + ++ + + + T +++
Sbjct: 948 VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKK 1007
Query: 218 MTKMQENFIAMEAEWKDEKQRLLKDIESK----DVRISSLE-EANKLLEAARFEISLEHS 272
+ ++++ + E +D+K+R ++ +E + +SS++ E + L+ A +S E
Sbjct: 1008 LMEVEKE----KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 273 --KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
+ QE + L +E K ++ + S+ ++ E T+K E
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR-QHLEETTQKAES 1122
Query: 331 LEHLNCQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK---MKSP 385
+ L C+ +E L+++++ + + ++ I + S + AS ++ P
Sbjct: 1123 -QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
Query: 386 WS-QLSSETLNQDTDKKI-----NKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+ LS E +Q+ +I + EIA+ + + + + E++
Sbjct: 1182 LNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDS 1241
Query: 440 XXXXGKDTLI-AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
+ + A+ +H++ M+ ++V T + + + +E+L+Q+L V
Sbjct: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM--LREEKERLEQDLQQMQAKVRK 1299
Query: 499 KDL-IEKLKSAEEQITQLNDEIDAANKNMIK-VKS----NHKLKLKQMQKTIDNFSKVSD 552
+L I L+ A ++++ + + A K + + VK N L +Q + + K+
Sbjct: 1300 LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLS 1359
Query: 553 SN----KEIVRLTEELHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM------IESDVYK 600
K I +LTEE+ L ++A N Q + + D ++ I+ D+
Sbjct: 1360 EKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDA 1419
Query: 601 KMIEMENLAET--RLKAISL--------LESQKFDLVQELHILQQKYDEVEDKLADISQL 650
K+I+++ +T ++K I L++Q+ +++ + E + ++ +L
Sbjct: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK- 709
+ +E KS LE Q++ L + E NL+ QL + L D +D +
Sbjct: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
Query: 710 --LQNYIQENMDLTDKLEKMSAEKISELLA---KINHEEQSKIQTQFGIDAKIQERDLYI 764
L+ I E + T K + KI+ L ++ E + Q +D + E D+ I
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
++S+ Y+ RI RLE + ++R + + + + E+Q+
Sbjct: 1600 TALKSQ---YEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 122/647 (18%), Positives = 256/647 (39%), Gaps = 39/647 (6%)
Query: 91 SESLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT 150
S L++K + +EK KQ + KR + + ++ + ++T
Sbjct: 997 SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
Query: 151 -IKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXX 209
+ + A Q + KI ++ Q K E++ ++ A +
Sbjct: 1057 ALSNEQQARRDCQEQAKIA----VEAQNKY-ERELMLHAADVEALQAAKEQVSKMASVRQ 1111
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDV-RISSLEEANKLLEAARFEIS 268
E+T Q K + + +A W +E++R+LKD SK V R LE+ N+LL ++S
Sbjct: 1112 HLEETTQ---KAESQLLECKASW-EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL--TK 326
+ +E Q I + EI E E+A + L +
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET-RFEVAQVESLRYRQ 1226
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
++ELLE + +EL++ L + + + + L+ + N +
Sbjct: 1227 RVELLE-------RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 387 SQLSSETLNQDTDKKINKNEIAKLEMV-IQSLNKDLVDKEYVI-SEKDTXXXXXXXXXXG 444
+ E L QD + K +L+++ +Q N +L +K ++ +EK
Sbjct: 1280 RE-EKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
Query: 445 KDTLIAQLQ---LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE----LNDEIKDVN 497
L++Q + E + + +H + EI +++ ++ + N++ +
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 498 VKDLIEKLKSAEEQITQLND----EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+K+ + K+++ +E I + D +I K + +VK + Q ++ KV ++
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETR 612
+ + +E H Q++ EL+E + +S ++ + +K E NL E
Sbjct: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
++ S L + DL +Q ++ +K + + V ++ K HL D L+
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEK---EEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
+EL L K++L I L++ E +++L+ ++E+ +
Sbjct: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
>DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein.
Length = 2479
Score = 103 bits (247), Expect = 5e-21
Identities = 264/1370 (19%), Positives = 577/1370 (42%), Gaps = 126/1370 (9%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISS----LEEANKLLEAARFEISLE 270
+ Q + + + +++ + WK E + + ++ + ++ ++E N LL A + + S E
Sbjct: 816 RHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMD-SDE 874
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K+ E + +E + + E E++ + ++ E+ +KI
Sbjct: 875 MKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGC 934
Query: 331 LEHLN----CQIRQTNKELENKLATMGTE--SKAVSSPSKKGSPLISRKSGRNTASKMKS 384
L+ +I K ++N ++ E +K + + K ++ + N + S
Sbjct: 935 LQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKD---NMLVQRTS 991
Query: 385 PWSQLSSETLN-QDTDKKINKN-EIAK--LEMVIQSLNKD--LVDKEYVISEKDTXXXXX 438
L E ++ ++ + INK EI K L + Q+ ++ L ++ + K +
Sbjct: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD 1051
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
K T++ +L +Q E H E + K E+ EL + ++
Sbjct: 1052 IVSISKKITMLEMKELNERQRAE-----HCQKMYEHLRTSLKQMEERNFELETKFAELTK 1106
Query: 499 KDLIEKLKSAEEQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTID-NFSKVSDSNKE 556
+L A++ L DE+ D+ +K + L+L++ + + SK+ + + +
Sbjct: 1107 INL-----DAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREIS-D 1160
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
I R E+ + Q+ + E E +L++ L+DY + +S + K +L + A+
Sbjct: 1161 IARRQVEILNAQQQSRDKEVE--SLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATAL 1218
Query: 617 SLLES--QKFDLVQELHI-LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA 673
LES K ++ ++ L+QK DE E L ++L+ ++ HL + I +L
Sbjct: 1219 GKLESITSKLQKMEAYNLRLEQKLDEKEQALY-YARLEGRN-----RAKHLRQTIQSLRR 1272
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK-LE-KMSAEK 731
+ + K K T+ L+NDK IM +++N QE+ ++ +K LE ++ +
Sbjct: 1273 QFSGALPLAQQEKFSK-----TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKG 1327
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR 791
+ EL++ + ++ Q KI+E L + EL K K I L I+ E
Sbjct: 1328 LEELISTL--KDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERT 1385
Query: 792 RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL 851
SLE + Q + +E+Q A+ + +E +L +L + + + E +
Sbjct: 1386 ISSLEEEIVQQNKFHEERQMAWDQ---REVDLERQLDIFDRQQNEILNAAQKFEEATGSI 1442
Query: 852 QKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL---K 908
+ L NQ L+I+L ++++ ++E E + + ++ LR E N+
Sbjct: 1443 PDPSLPL--PNQ-LEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRD 1499
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
++ +E + L + E E L E + E + L ++ + ++A+L + +
Sbjct: 1500 KVINELR-LRLPATAEREKLIAELGRK-EMEPKSHHTLKIAHQT----IANMQARLNQKE 1553
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA----LLKQKDEE 1024
++ +E+ + E++ KH + Q + +NK L+KQ
Sbjct: 1554 EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTP 1613
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK-QHNEELQI 1083
+ I A++ V++ + L+ KL+ + ++++R +++ + K + E +++
Sbjct: 1614 VPTNKHFIRLAEME--QTVAEQDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKL 1670
Query: 1084 LVRE-QDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX--XXXXXX 1138
++E +D++K++K L + ++ + E + S ++ + +
Sbjct: 1671 QLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERL 1730
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
L ++E+++ R++L E A++ +E +II + + +
Sbjct: 1731 KSQLALKEKQQKALSRALL-ELRAEMTAAAEE---RIISATSQKEAHLNVQQIVDRHTRE 1786
Query: 1199 LKSKLEQLNTEN----DNLLSTVAELRSSISSAVDQRGFEIAELWKQH--LAQREADFQK 1252
LK+++E LN EN L T +S++ ++ E+ + K + + + + + +
Sbjct: 1787 LKTQVEDLN-ENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQ 1845
Query: 1253 TEHELRVQLSAFES--KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
EL+ Q+ S + + L D+ QS +E K+ +E L+ K++ E L+ ++
Sbjct: 1846 ENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE--NQLEGKVE--EVDLKPMK 1901
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
EK A + E++R E E +K + ++ T + +++
Sbjct: 1902 EKNA----KEELIRWE-EGKK--WQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKAD 1954
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL-THQLELKDSEIYQKTHEYTITLTQ 1429
E+ +K R ++E ++ EL L+L++ +Y + H+ +
Sbjct: 1955 KEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV 2014
Query: 1430 RND-EFEN--VRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVK 1486
D +N ++++L EK+ TY K S I E+ +H Q+E E+++
Sbjct: 2015 VEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGI------ESDDH---CQREQELQK-- 2063
Query: 1487 LIEELNVKITESVSLNKQVAELNK---ALEEEVAKTNEMQTALENQEIEI 1533
E L + +E++ L Q+ + NK L+ +V EM L+ ++ E+
Sbjct: 2064 --ENLKLS-SENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEV 2110
Score = 101 bits (241), Expect = 3e-20
Identities = 297/1482 (20%), Positives = 608/1482 (41%), Gaps = 157/1482 (10%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIE-AKNKATTXXXX 198
Q ++T I +KDN L ++ +E + L+E++ ++ +E K K T
Sbjct: 968 QYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQA 1027
Query: 199 XXXXXXXXXXXXXEDTKQQMTK-----MQENFIAMEAEWKDEKQRL---LKDIESKDVRI 250
+ K+ +T + + +E + +E+QR K E +
Sbjct: 1028 WEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSL 1087
Query: 251 SSLEEANKLLE---AARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK 307
+EE N LE A +I+L+ K+ Q L +Q I EK
Sbjct: 1088 KQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD--RQRILEL--EK 1143
Query: 308 TEIEEKGSLEIANMTELTKKIEL-LEHLNCQIRQTNKELEN---KLATMGTESKAVSSPS 363
E+E K +E++ + E++ +E LN Q + +KE+E+ +L +S S +
Sbjct: 1144 NEMELK--VEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIA 1201
Query: 364 KKGSPLISRKSGRNTA-SKMKSPWSQLSS-ETLNQDTDKKINKNEIAKLEMVIQSLNKDL 421
K +S + TA K++S S+L E N ++K+++ E A ++ N+
Sbjct: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
Query: 422 VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
++ + S + L L Q+ ++I + + + + K
Sbjct: 1262 HLRQTIQSLRRQFSGA--------------LPLAQQEKFS-KTMIQLQNDKLKIMQEMKN 1306
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
+Q + + ++ ++ +K LK EE I+ L D K KV + H +K+++++
Sbjct: 1307 SQQEHRNMENKTLEMELK-----LKGLEELISTLKD-----TKGAQKVINWH-MKIEELR 1355
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY-K 600
+ N+E+V+ EE+ +L+ ++E E +L+ +V + + +
Sbjct: 1356 L------QELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ 1409
Query: 601 KMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
+ +++E + + + + Q+ +++ QK++E + D S +Q+ EI
Sbjct: 1410 REVDLE-------RQLDIFDRQQNEILNAA----QKFEEATGSIPDPSLPLPNQL--EIA 1456
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ---EN 717
++E I + ++ + E LK +KE + ++ ++N+L+ + E
Sbjct: 1457 LRKIKENIRIILETRATCKSLEEKLK-EKESALRLAEQNILSRDKVINELRLRLPATAER 1515
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
L +L + E S KI H+ + +Q + ++ ++ Y +E + +
Sbjct: 1516 EKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKK--YQRLLEKAREEQREI 1573
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY-----SEYTIQEDELVNRLA---- 828
+ + EE + ++ R LE +AD S + KQ A+ S + ++ RLA
Sbjct: 1574 VKKHEEDLHILHHR---LELQADS--SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 1628
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQIL---LEENQNLQISLSDMQQHYNALVEKANR 885
+ + D + L++++ +++L+++ +I ++E +N+++ L Q+++ V+K
Sbjct: 1629 TVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQL---QENHEDEVKKVK- 1684
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
AE E KY ES + L QK+ +E ++ +
Sbjct: 1685 ---AEVEDLKYLLDQSQKESQCLK-----SELQAQKEANSRAPTTTMRNLVER-LKSQLA 1735
Query: 946 LNEKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
L EK +K + + +L A++ + +E + +++D+H ++ +TQ D
Sbjct: 1736 LKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLN 1795
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
E + KL LK +L +N+ Y +K+ + +++ +E+
Sbjct: 1796 ENLL----KLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY-NKILREKEEIDQENDEL 1850
Query: 1065 QRVSKQL---LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
+R K+L L K + Q L+ E ++K+L+ + EG + ++PM
Sbjct: 1851 KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLEN----------QLEGKVEEVDLKPM 1900
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLE- 1179
+ N + K++ ++E+ + + +LNT L++ + K + +
Sbjct: 1901 KEK-NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT-LKDLFAKADKEKL 1958
Query: 1180 TLNTEL--TGHDVVNQEQINQLKSK--LEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
TL +L TG V I L+S+ LE+L N +L + + +R+ + D E
Sbjct: 1959 TLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VED 2017
Query: 1236 AELWKQHLAQR----EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ 1291
L ++L ++ E F K + + +S ES D Q + + + +
Sbjct: 2018 LHLQNRYLQEKLHALEKQFSKDTYS-KPSISGIESD-----DHCQREQELQKENLKLSSE 2071
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
L+ +L+ + L L+ + D+ E L+ E +V +
Sbjct: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKE--KAEVQRKLGHVRGSGRSGKTIPE 2129
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA-EAKVLELTHQLE 1410
L K++ E+ + EN QLKK+S + N+ +A++ +L L
Sbjct: 2130 LEKTIGLMKKVVEK----VQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG 2185
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ S Y+ + T + N E +R++L + E L K + L IL KM
Sbjct: 2186 HQLSMHYESKTKGTEKIIAEN---ERLRKELKKETDAAEKLRIAKNN-LEILNEKMTVQL 2241
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
+ +E R +E + K +S+ + + K LE ++AK N+ T L+ Q
Sbjct: 2242 EETGKRLQFAE-SRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLK-QL 2299
Query: 1531 IEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
++ T ++ N N KI KHV ++T+QG +L
Sbjct: 2300 VKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKREL 2341
Score = 97.9 bits (233), Expect = 3e-19
Identities = 303/1524 (19%), Positives = 626/1524 (41%), Gaps = 147/1524 (9%)
Query: 143 DVTHLSNTIKEKDNALSVL--QVKM--KIMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
+V L I+E+D+ + +L QV+ K ME +++ NE ++ A+T
Sbjct: 349 NVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNE----LQRNKGASTLSQQ 404
Query: 199 XXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEAN 257
E TK+ + +A KD E LK ++ + + LE+A
Sbjct: 405 THMKIQSTLDILKEKTKE--AERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAV 462
Query: 258 KLLEAARFEISLEHSK---LAQELEQXXXXXXXXXXXXXXLAKQ-SIEPSCE-EKTEIEE 312
++ + +I + + L +E+ + L ++ +EP + TE
Sbjct: 463 VEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRN 522
Query: 313 KGSLEI----ANMTELTKKIELLEH----LNCQIRQTNKELENKLATMG--TESKAVSSP 362
L+ A L K+IE LE L +IRQ +E + AT G TE ++
Sbjct: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTEN 582
Query: 363 SKKGSPLISRKSGRNTASKMKSPWSQ---LSSETLNQDTDKKINKNEIAKLEMVIQSL-- 417
+G + RK + M S+ LS E + ++ D + ++ IAK + ++ L
Sbjct: 583 ISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVE 642
Query: 418 -NKDLVD--KEYVISEK------DTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
NK L + KE + + K D + L+ ++ ++ + + SL H+
Sbjct: 643 ENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASL-HL 701
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
V+++ E+L+QEL + K+ + +Q+ + N +ID K
Sbjct: 702 KAQ---VDQLTGRNEELRQELRESRKEAI---------NYSQQLAKANLKIDHLEKETSL 749
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE-LHHLSQKVAELEEEKGNLQLHLVD 587
++ + + + K ID ++ S+ I+ E L HL Q++ E++ NL+ L D
Sbjct: 750 LRQSEGSNV--VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLED 807
Query: 588 YDSG----RMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
Y+ R +S +YK+ + + +T K I + + D VQ+ I ++Y+ + +
Sbjct: 808 YNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA 867
Query: 644 LA-DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
L D +++ + K L+ +L L + L+ + E+ + +E +
Sbjct: 868 LQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAE 927
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKIS----ELLAKINHEEQSKIQTQFGIDAKIQ 758
+ + LQ + + + L+K+ +S EL K +E +K + D +
Sbjct: 928 VCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLV 987
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
+R +E++E E K ++ + + + + +++ +++E+ +Q E ++ +I
Sbjct: 988 QRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSI 1047
Query: 819 QEDELVN--RLAVLMDHDRVVEKQLLE-IEHENKELQKKNQILLEENQNLQISLSDMQQ- 874
++V+ + +++ + E+Q E + + L+ + + E N L+ +++ +
Sbjct: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKI 1107
Query: 875 HYNAL-VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL---EI 930
+ +A VE+ R +LA+S S R L++ E + + V K +EI D+ ++
Sbjct: 1108 NLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK-VEVSKLREISDIARRQV 1166
Query: 931 EF-NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN-LEL 988
E N Q +S RDK+V + + + ++Y Q + + K + N+++ + E + LE
Sbjct: 1167 EILNAQQQS--RDKEVESLRMQL-LDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLES 1223
Query: 989 IDKHVQKQQT------QSPDYTEQ--YINEINKLNALLKQKDEEIIALNQKINNAQVSYM 1040
I +QK + Q D EQ Y + N K + I +L ++ + A +
Sbjct: 1224 ITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA-KHLRQTIQSLRRQFSGALP--L 1280
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETK- 1099
+ + + Q + +EM+ ++ + + E+++ ++ ++ I LK+TK
Sbjct: 1281 AQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKG 1340
Query: 1100 ----LTFEMNIPKTEGMIISSTIEPMSDDA-----NNVDXXXXXXXXXXXXLKVQEEEEF 1150
+ + M I + + E + D NN+ ++ ++ +F
Sbjct: 1341 AQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEE-EIVQQNKF 1399
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNT-----ELTGHDVVNQEQI-NQLKSKLE 1204
+ER + +Q +++ E Q Q E LN E TG + NQL+ L
Sbjct: 1400 HEERQMAWDQR-EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALR 1458
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
++ +L T A +S ++ L +Q++ R+ K +ELR++L A
Sbjct: 1459 KIKENIRIILETRATCKSLEEKLKEKES--ALRLAEQNILSRD----KVINELRLRLPAT 1512
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTM--EQVTSLQNKLQDKEEHLRNLQEKYADVIN-QIE 1321
+ + + + + + +++ + + + + ++Q +L KEE L+ Q Q E
Sbjct: 1513 AEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQRE 1572
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
I++ ED + L Q+ + +QS + ++ +
Sbjct: 1573 IVKKHEEDLHILHHRLELQADSS-------LNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 1625
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
++ K+ +++ LE + K E+ Q EN ++
Sbjct: 1626 MEQTVAEQDDS--LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQ---ENHEDEV 1680
Query: 1442 VEYEKRIEDLTY-----EKESELAILRLKMHENAN-HYETMQKESEIERVKLIEELNVKI 1495
+ + +EDL Y +KES+ L+ + AN T + +ER+K +L +K
Sbjct: 1681 KKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLK--SQLALK- 1737
Query: 1496 TESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ 1555
KQ L++AL E A EM A E + I + + N+Q +V + +++
Sbjct: 1738 ------EKQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLNVQQIVDRHTRELK 1788
Query: 1556 KHVSFASDTKQGRDEQLDNTMNKE 1579
V ++ E L + N+E
Sbjct: 1789 TQVEDLNENLLKLKEALKTSKNRE 1812
Score = 96.7 bits (230), Expect = 6e-19
Identities = 279/1415 (19%), Positives = 589/1415 (41%), Gaps = 140/1415 (9%)
Query: 237 QRLLKDIESKDVRISSLEEANKL-LEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXL 295
Q L+K +++++V ++ LEE K E A+FE L+ + E E L
Sbjct: 56 QSLMK-MKAQEVELA-LEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFL 113
Query: 296 AKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTE 355
+ C+ + ++E+K + ++ K++E + +N Q+ N+E EN+ + + E
Sbjct: 114 RNEI----CQLEKQLEQKDR----ELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRE 165
Query: 356 SKAVSSPSKK--------GSPLISRK----SGRNTASKMKSPWSQLSSETLNQDTDKKIN 403
+K + +++ + S+K S R S +S S+ + E + + +
Sbjct: 166 NKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTL 225
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE---HQQHM 460
K+E+ Q + K+L + + + D +I QL+ E +Q +
Sbjct: 226 TEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQV 285
Query: 461 EGPSLIHVGTNTED----VNEIAKVQE--QLKQELNDEIKDVN--VKDLIEKLKSAE--- 509
+ + + N ED V AKV+E + +DEI + + +L EKLK+A+
Sbjct: 286 QELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDA 345
Query: 510 --EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT---IDNFSKVSDSNKEIVRLTEEL 564
+ L I + + + + K+M+K I++ NK L+++
Sbjct: 346 DKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQT 405
Query: 565 HHLSQKVAELEEEK---GNLQLHLVDYDSGRMIES--DVYKKMIEMENLAETRLKAISLL 619
H Q ++ +EK L + D+ + + K++ + E+ A+ +
Sbjct: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
Query: 620 ESQKFDLV---QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
++ K + +E+ IL ++ +++E K++D L ++ E + + ID L+ +
Sbjct: 466 KNCKNQIKIRDREIEILTKEINKLELKISDF--LDENEALRERVGLEPKTMID-LTEFRN 522
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ-------------ENMDLTDK 723
L + + + + L I+ LE ++ D+ K++ Q E+++LT+
Sbjct: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTEN 582
Query: 724 L---EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+ +++S K+ L K E QSK +F + ++ E++ +E + ++K+++++
Sbjct: 583 ISQGDRISERKLDLLSLKNMSEAQSK--NEF-LSRELIEKERDLERSRTVIAKFQNKLKE 639
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
L E +E+ + + ++ K S + LVN A+ + +
Sbjct: 640 LVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN--AIESKNAEGIFDA 697
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN-RTDLAESESTKYQTQ 899
L ++ + +L +N+ E Q L+ S + +Y+ + KAN + D E E+ +
Sbjct: 698 SLHLKAQVDQLTGRNE---ELRQELRESRKE-AINYSQQLAKANLKIDHLEKET----SL 749
Query: 900 LRDLE-SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
LR E SN+ + I I + + E+ + + +K+ + E ++E
Sbjct: 750 LRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYN 809
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
+ A ++ ++ + ++ +E K + I + +K + Q + N LNAL
Sbjct: 810 RKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQ 869
Query: 1019 KQKDE--EIIALN-QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
DE +I+A N +KI QV+ S++ Y T L +E ++++ ++ K
Sbjct: 870 MDSDEMKKILAENSRKITVLQVNEKSLIRQY--------TTLVELERQLRKENE-----K 916
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q NE L + E ++I L+ K EM I K + ++ + D N+V
Sbjct: 917 QKNELLS-MEAEVCEKIGCLQRFK---EMAIFKI------AALQKVVD--NSVSLSELEL 964
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII--QLETLNTELTGHDVVNQ 1193
+ + +Q+ ++L ++++ N E EC + Q+E++N EL + +
Sbjct: 965 ANKQYNELTAKYRDILQKDNMLVQRTS--NLEHLECENISLKEQVESINKELE----ITK 1018
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADFQ 1251
E+++ ++ EQ T+ N S +S +S + +I L + L QR Q
Sbjct: 1019 EKLHTIEQAWEQ-ETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077
Query: 1252 KTEHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTMEQVTSLQNKLQDKE-EH 1305
K LR L E + +L T+ ++ +++ E S+ + D + +
Sbjct: 1078 KMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQR 1137
Query: 1306 LRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-QMQE 1364
+ L++ ++ ++ LR EI D LR + Y+ Q E
Sbjct: 1138 ILELEKNEMELKVEVSKLR-EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDE 1196
Query: 1365 QSIL-NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEY 1423
+S++ +++ N L+ S ++ EA L L +L+ K+ +Y E
Sbjct: 1197 KSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEG 1256
Query: 1424 TITLTQRNDEFENVRQQ------LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
+++R+Q L + EK + + + +L I++ + H
Sbjct: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMEN 1316
Query: 1478 KESEIE-RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL 1536
K E+E ++K +EEL + ++ K V + +EE + ++ L + EI L
Sbjct: 1317 KTLEMELKLKGLEELISTLKDTKGAQK-VINWHMKIEELRLQELKLNRELVKDKEEIKYL 1375
Query: 1537 NDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQ 1571
N+ I+ + + + +I + F + + D++
Sbjct: 1376 NNIISEYERTISSLEEEIVQQNKFHEERQMAWDQR 1410
Score = 95.1 bits (226), Expect = 2e-18
Identities = 183/944 (19%), Positives = 398/944 (42%), Gaps = 63/944 (6%)
Query: 165 MKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQEN 224
+KI TI ++Q ++N+K+++++ + ++ ++
Sbjct: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADS 1594
Query: 225 FIAM--EAEWKDEKQRLLKDIESKD-VRISSLEEANKLLEAARFEISLEHSKLAQELEQX 281
+ + W KQ +K +R++ +E+ + + + ++ K++Q+LE+
Sbjct: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ 1654
Query: 282 XXXXXXXXXXXXXLAKQSIEPSCEE----KTEIEE-KGSLEIANMTELTKKIELLEHLNC 336
+ Q E +E K E+E+ K L+ + K EL
Sbjct: 1655 REITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEA 1714
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
R + N + + ++ K S + TA+ + S S + +
Sbjct: 1715 NSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL 1774
Query: 397 DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
+ + ++++ +L+ ++ LN++L+ + + + + + Q +
Sbjct: 1775 NVQQIVDRHT-RELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY 1833
Query: 457 QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
+ + I N E +I ++ L+ + + K +++L K+K E Q+
Sbjct: 1834 NKILREKEEIDQ-ENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV 1892
Query: 517 DEIDAANKNMIKVKSNHKL----KLKQMQKTIDNF-SKVSDSNKEIVRLTEELHHLSQKV 571
+E+D K M + + +L + K+ Q I+ +K+ + E+ LT++L+ L
Sbjct: 1893 EEVDL--KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLF 1950
Query: 572 AELEEEKGNLQLHL------VDYDSG-RMIESDVYKKMIEMENL-AETRLKAISLLESQK 623
A+ ++EK LQ L VD G R +ES+ + ++ NL E + + ++
Sbjct: 1951 AKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALP 2010
Query: 624 FD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
D +V++LH LQ +Y +++KL + + S S+ +E ++E L
Sbjct: 2011 RDSVVEDLH-LQNRY--LQEKLHALEKQFSKDTYSKPSISGIESD----DHCQREQELQK 2063
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
ENLKL E + + LE +D+ +L+N +++ ++ + L+K AE + L +
Sbjct: 2064 ENLKLSSENIELKFQ-LEQANKDLP-RLKNQVRDLKEMCEFLKKEKAE-VQRKLGHVRGS 2120
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSLERKADQ 801
+S +T ++ I +E ++ E + K L E +A +E L+ + ++
Sbjct: 2121 GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEK 2179
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L ++L + + E + E ++ +++R+ ++ E + K KN + +
Sbjct: 2180 LKAHLGHQLSMHYESKTKGTE-----KIIAENERLRKELKKETDAAEKLRIAKNNLEIL- 2233
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK 921
N+ + + L + + + + + A+S+S K R E+ LK + +T I +K
Sbjct: 2234 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKEL----ETDIAKK 2289
Query: 922 KKEIEDLE--IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
+ I DL+ ++ T+ E + E+ K +++V + Q K ++ L +
Sbjct: 2290 NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANH 2349
Query: 980 ELNKMNLELIDK-HVQKQQTQS----PDYTEQYINEINKLNALLKQKD-------EEIIA 1027
+L+K ELI + K Q+ + PD +Q +I L LK D EEI
Sbjct: 2350 QLDKEKAELIHQIEANKDQSGAESTIPD-ADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
L +++ N S+ + D + + K +EE+++++S+QL
Sbjct: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Score = 86.2 bits (204), Expect = 9e-16
Identities = 227/1289 (17%), Positives = 521/1289 (40%), Gaps = 137/1289 (10%)
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
D + +NEI +LE ++ +++L D E + ++ + ++L+ E+++
Sbjct: 109 DTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKR 168
Query: 459 HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDE 518
+ + +D+ + K + K+ L + + D +L ++ Q DE
Sbjct: 169 LKKKNEQL-----CQDIIDYQKQIDSQKETLLSRRGEDS--DYRSQLSKKNYELIQYLDE 221
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEK 578
I + K++ ++ K +++++ K++D E R+ +H + +L++E
Sbjct: 222 IQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTD---EYNRMKAIVHQTDNVIDQLKKEN 278
Query: 579 GNLQLH---LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ QL L D + E D M+ + E +S + + + Q LH L++
Sbjct: 279 DHYQLQVQELTDLLKSKNEEDDPI--MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
Query: 636 KYDEVE---DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
K + DK +++ LQ + + L EQ++ + ++ +IE+LK + ++
Sbjct: 337 KLKNAQLDADK-SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN 395
Query: 693 YG--TIKDLENDKE----DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
G T+ + K DI+ + + +L + + +++ E L ++ E
Sbjct: 396 KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGV 455
Query: 747 IQTQFGI------DAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKA 799
+ + +I+ RD IE + E++K + +I L+E+ A+ E R LE K
Sbjct: 456 YGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRE--RVGLEPKT 513
Query: 800 D-QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
L + K +Y + L+ + L + ++K++ ++ E + + +
Sbjct: 514 MIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLT 573
Query: 859 LEE-NQNLQISLSD-MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
E+ N IS D + + L+ N ++ A+S++ +L + E +L+R +T
Sbjct: 574 TEDLNLTENISQGDRISERKLDLLSLKNMSE-AQSKNEFLSRELIEKERDLER----SRT 628
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY----VTQLEAQLQEYKNNIE 972
+I + + ++++L +E N Q+E +++ ++ +K+ + + + L+ N IE
Sbjct: 629 VIAKFQNKLKEL-VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIE 687
Query: 973 NLNMN------------VEELNKMNLELIDKHVQKQQTQSPDYTEQY------INEINKL 1014
+ N V++L N EL + +++ + ++ +Y++Q I+ + K
Sbjct: 688 SKNAEGIFDASLHLKAQVDQLTGRNEEL-RQELRESRKEAINYSQQLAKANLKIDHLEKE 746
Query: 1015 NALLKQKDEEIIALN--QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
+LL+Q + + + S S+++ L +LEN E++++ + L
Sbjct: 747 TSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLE 806
Query: 1073 DSKQ------HNEEL---QILVREQD--DQIKELKETKLTFEMNIPKTEGMI--ISSTIE 1119
D + H + L + L ++ + K +KE K E + + + ++ +
Sbjct: 807 DYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLN 866
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLE 1179
+ D++ + L+V E+ I++ + L E +L E ++ +++ +E
Sbjct: 867 ALQMDSDEMKKILAENSRKITVLQVNEKS-LIRQYTTLVELERQLRKENEKQKNELLSME 925
Query: 1180 TLNTELTG----------HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSIS--SA 1227
E G + +++ L +L N A+ R + +
Sbjct: 926 AEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNM 985
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRV---QLSAFESKYEQLLDSVQSSTQEETN 1284
+ QR + L ++++ +E + EL + +L E +EQ S+ ++
Sbjct: 986 LVQRTSNLEHLECENISLKE-QVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAK 1044
Query: 1285 KIVTMEQVTSLQNKL----------QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF 1334
K +T + S+ K+ + + EH + + E + Q+E E+E +
Sbjct: 1045 KSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAEL 1104
Query: 1335 XXXXXXXXXXXXXXXXDLRTE-NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXX 1393
+L +++ Q IL + + +LK
Sbjct: 1105 TKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARR 1164
Query: 1394 RVN---------DAEAKVLE---LTHQLELKDSEIYQKTHEYTITLTQRN----DEFENV 1437
+V D E + L L +Q + + + K H++ ++L + E++
Sbjct: 1165 QVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
Query: 1438 R---QQLVEYEKRIEDLTYEKESELAILRLKMHENANHY-ETMQKESEIERVKLIEELNV 1493
Q++ Y R+E EKE L RL+ A H +T+Q L
Sbjct: 1225 TSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQE 1284
Query: 1494 KITES-VSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSS 1552
K +++ + L ++ + ++ + M+ E+++ L + I+ L++ A
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGA--- 1341
Query: 1553 KIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
QK +++ ++ R ++L +N+EL+
Sbjct: 1342 --QKVINWHMKIEELRLQEL--KLNRELV 1366
Score = 54.8 bits (126), Expect = 2e-06
Identities = 172/901 (19%), Positives = 381/901 (42%), Gaps = 87/901 (9%)
Query: 93 SLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIK 152
SL LK+ +E+ ++ EL + I ++ D+ +L + +
Sbjct: 1639 SLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQ 1698
Query: 153 EKDNAL-SVLQVKMKIME----TTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXX 207
++ L S LQ + + TT+ +L E++ + + E + KA +
Sbjct: 1699 KESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAA 1758
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
E+ T +E + ++ + L +E + + L+EA K + +
Sbjct: 1759 A---EERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSL 1815
Query: 268 SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEEKGS-LEIANMTELT 325
+ + L EL++ K+ I+ +E K +I+ S L+ +T+
Sbjct: 1816 TDNLNDLNNELQKKQKAYNKILRE-----KEEIDQENDELKRQIKRLTSGLQGKPLTD-- 1868
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
K L+E L ++++ +LE K+ + + K + + K LI + G+ +K++
Sbjct: 1869 NKQSLIEELQRKVKKLENQLEGKVEEV--DLKPMKEKNAK-EELIRWEEGKKWQAKIEGI 1925
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
++L K + E+ L + +L KDL K EK T
Sbjct: 1926 RNKL-----------KEKEGEVFTLTKQLNTL-KDLFAK--ADKEKLTLQRKLKTTGMTV 1971
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD--LIE 503
D ++ LE ++ +E N + N+I ++ + ++D+++++ L E
Sbjct: 1972 DQVLGIRALESEKELEELKK----RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE 2027
Query: 504 KLKSAEEQI---TQLNDEIDA--ANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
KL + E+Q T I ++ + + + K LK + I+ ++ +NK++
Sbjct: 2028 KLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLP 2087
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDY-DSGRMIESDVYKKMIEMENLAETRLKAIS 617
RL ++ L + L++EK +Q L SGR K + E+E K +
Sbjct: 2088 RLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-----GKTIPELEKTIGLMKKVVE 2142
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSV--HLEEQIDALSASK 675
++ + L + IL +K+A+I Q +++++ +E++ + HL Q+ SK
Sbjct: 2143 KVQRENEQLKKASGIL------TSEKMANIEQ-ENEKLKAELEKLKAHLGHQLSMHYESK 2195
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
+ E + + E+L K+L+ + D KL+ + N+++ + EKM+ + + E
Sbjct: 2196 TKGT---EKIIAENERLR---KELKKET-DAAEKLR-IAKNNLEILN--EKMTVQ-LEET 2244
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
++ E Q + G D+K + + E++L + ++ I + +SI ++ L
Sbjct: 2245 GKRLQFAESRGPQLE-GADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQ----L 2299
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
++A + ++K Y+E Q+ +++ + + ++ ++++L + N +L K+
Sbjct: 2300 VKEATER----EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEK 2355
Query: 856 QILLE--ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
L+ E Q + L EK DL E++ + + L+ +K++ E
Sbjct: 2356 AELIHQIEANKDQSGAESTIPDADQLKEKIK--DL-ETQLKMSDLEKQHLKEEIKKLKKE 2412
Query: 914 HQTLIVQKKKEIEDLEIEFNTQI-ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
+ +EIEDL+ + ++ ++ + ++KV + +E + + A +E+++ E
Sbjct: 2413 LENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAAS-EEFEDEEE 2471
Query: 973 N 973
+
Sbjct: 2472 S 2472
>BC060769-1|AAH60769.2| 1107|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1107
Score = 103 bits (246), Expect = 7e-21
Identities = 204/1022 (19%), Positives = 432/1022 (42%), Gaps = 103/1022 (10%)
Query: 561 TEELH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
++E+H LS+K+A+L + L +++S D +++ I+ + LAETR K +
Sbjct: 4 SQEMHLKLSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQ-QILAETREKILQYK 62
Query: 620 E--SQKFDLVQELHILQQKY-DEVEDKLADISQLQSD-------QVCSEIKSVH----LE 665
+++ DL +++ +L+ D ++ K +++ ++ Q+C+E + V +
Sbjct: 63 SKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 122
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYG-TIKDLE----NDKEDIMNKLQNY---IQEN 717
+++ + +E L++ E+ ++DL+ + ++++ Q++ + +
Sbjct: 123 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRQEIQELLKSQQDHSASVNKG 182
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---ERDLYIENIESELSKY 774
+ ++L +M E ++++L ++ E + I+ G K Q ER+L S+L
Sbjct: 183 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK-RSQLFTA 241
Query: 775 KSRICRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+S E+ + ++ + L + +L + LQ Q + +L LA+
Sbjct: 242 ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 301
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
++ +V++KQL + + L K++ E L + +QQ + LV KA+ + ++
Sbjct: 302 NNVQVLQKQLDDAKEGEMALLSKHK---EVESELAAARERLQQQASDLVLKASHIGMLQA 358
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ ++DLES R+ L E E + TQ + +++L + +
Sbjct: 359 TQMTQEVTIKDLESEKSRVNERLSQL------EEERAFLRSKTQSLDEEQKQQILELEKK 412
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
N TQ E +E KN L V +LN+ + + +++ K I +
Sbjct: 413 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 472
Query: 1012 NKLNA-LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
KL L +Q +++ + L + N Q ++ E KL ++ ++++ M R S+Q
Sbjct: 473 KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQD-MVRKSEQ 531
Query: 1071 -------LLDSKQHNEE-LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
L+ S Q ++E LQ + D +KE K+ L E + + E TI M
Sbjct: 532 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETIAAMK 590
Query: 1123 DDAN-NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE-LQECYTKIIQLET 1180
++ VD L+++ E QE S L+E+ + E + ++++QL+
Sbjct: 591 EEEKLKVDKMAHD-------LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKD 643
Query: 1181 L--NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
N ++ +NQ+ + L + +++ +L++ + + E+ EL
Sbjct: 644 REKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 703
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
+QH Q+ K H L Q E + EQ ++++ Q++ + ++ SL
Sbjct: 704 EEQH--QQRHKSLKEAHVLAFQTMEEEKEKEQR--ALENHLQQKHSA-----ELQSL--- 751
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
K+ H +++ ++ +++ LR E+EDE A DL N
Sbjct: 752 ---KDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH 808
Query: 1359 YK----QMQEQSILNINEENAQ--------LKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
+ +M+ + ++I+ ++ L++ V + LT
Sbjct: 809 QELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALT 868
Query: 1407 HQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEY-------EKRIEDLTYEKESEL 1459
+LE K EI + E + + ++ ++ EK I + K +EL
Sbjct: 869 KELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNEL 928
Query: 1460 -----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
A L++ + E Y + +ES+ E +++I EL +TE + K++ E NK +
Sbjct: 929 LKEINAALQVSLEEMEEKY--LMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQL 986
Query: 1515 EV 1516
E+
Sbjct: 987 EL 988
Score = 87.4 bits (207), Expect = 4e-16
Identities = 180/897 (20%), Positives = 368/897 (41%), Gaps = 85/897 (9%)
Query: 491 DEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKV 550
D +++++K L +K+ + I LN + D + +K H+ +++Q+ + K+
Sbjct: 2 DYSQEMHLK-LSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQI--LAETREKI 58
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE-MENLA 609
++ TEEL L +K+ LE +L+ H + + E + YK +E M+ A
Sbjct: 59 LQYKSKV---TEELD-LRRKIQVLES---SLEDH-IKMKQQALTEFEAYKHRVEDMQLCA 110
Query: 610 ET----RLKAISL-LESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVCSEIKSVH 663
E R+ +S +E + ++L Q + E DK + LQ+ EI+ +
Sbjct: 111 EAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR-QEIQELL 169
Query: 664 LEEQIDALSASK-----KEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
+Q + S +K +EL + +E+L E+L K L D E +NK Q++ +
Sbjct: 170 KSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERE 229
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK-IQERDLYIENIESELSKYKS 776
+D + + +AE + K + + + Q Q I K I + ++ ++ E
Sbjct: 230 LDTLKRSQLFTAESLQASKEK-EADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLD 288
Query: 777 RICRLEESIAVMEDRRYSLERKADQLG----SYLQEKQKAYSEYTIQEDEL--------- 823
+ +L+ ++A+ E+ L+++ D + L + ++ SE + L
Sbjct: 289 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL 348
Query: 824 -VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
+ + +L E + ++E E + ++ L EE L+ + + + +
Sbjct: 349 KASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILE 408
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES---- 938
+ + E++ T+ + R+L++ R+ E L K +E+L + + IE+
Sbjct: 409 LEKK-VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSN 467
Query: 939 AIRDKKVLN-EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQKQ 996
AIRDKK L + E++ + LE + + +ENL +E+ LN N E+ H+Q
Sbjct: 468 AIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEI--GHLQDM 525
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+S I L ++ E+ + + + +++ + E + Q
Sbjct: 526 VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEET 585
Query: 1057 LENM-EEEMQRVSKQLLD-----SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
+ M EEE +V K D ++ +E L E Q +E K++ ++ + + E
Sbjct: 586 IAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDRE 645
Query: 1111 GMIISSTIEPMSDDA--------NNVDXXXXXXXXXXXXLKVQ---EEEEFIQERSVLQE 1159
+ + +D N++ L+ Q E + QE L+E
Sbjct: 646 KNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEE 705
Query: 1160 QSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE 1219
Q + + L+E + ++ +T+ E + + Q S +L + D ++
Sbjct: 706 QHQQRHKSLKEAH--VLAFQTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHRESMEG 761
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLA--------QREADFQKTEHELRVQLSAFESKYEQL 1271
R + + FE+ + K LA Q A H +L+A + + E+
Sbjct: 762 FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERS 821
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+D + ++E +I T LQ +L+ +E H+ L ++ + I L E+E
Sbjct: 822 IDISRRQSKEHICRI------TDLQEELRHREHHISELDKEVQHLHENISALTKELE 872
Score = 73.7 bits (173), Expect = 5e-12
Identities = 132/758 (17%), Positives = 306/758 (40%), Gaps = 59/758 (7%)
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD-HDRVVEKQLLEIEHENKELQKKNQILL 859
+L + + K + DE + + L D H+ +++ L E + + + K L
Sbjct: 10 KLSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEEL 69
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
+ + +Q+ S ++ H K + L E E+ K++ + L + +H IV
Sbjct: 70 DLRRKIQVLESSLEDHI-----KMKQQALTEFEAYKHRVEDMQLCAEA-----QHVQRIV 119
Query: 920 QKKKEIEDLEIEFNTQIESA-------IRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNI 971
+E+E++ +F ++ S +DK++ L + + + + +L Q++ ++
Sbjct: 120 TMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRQEIQELLKSQQDHSASV 179
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI----IA 1027
EEL++M +E ++K +++ + + E Y ++NK + +++ + + +
Sbjct: 180 NKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLF 239
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQHNEELQIL 1084
+ + ++ + +++ + A + ++ E+Q V + LLD Q + +
Sbjct: 240 TAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAI 299
Query: 1085 ----VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
V+ Q+ + KE ++ + E + ++ E + A+++
Sbjct: 300 AENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR-ERLQQQASDLVLKASHIGMLQA 358
Query: 1141 XLKVQEE--EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
QE ++ E+S + E+ ++L E +K ++L+ E + ++++N+
Sbjct: 359 TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSK---TQSLDEEQKQQILELEKKVNE 415
Query: 1199 LK-SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL 1257
K ++ E E NL S + E + ++ A + E+A WK H+A +
Sbjct: 416 AKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELA--WKHHMAIEAVHSNAIRDKK 473
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
++Q+ E + L+ + Q + E + N + HL+++ K +
Sbjct: 474 KLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL 533
Query: 1318 NQIEILRSEIEDEKVAF---XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEEN 1374
E L + ++D + ++ E + +Q E++I + EE
Sbjct: 534 GSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE 593
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEF 1434
+LK + + +L +L L+ E + L Q D
Sbjct: 594 -KLKVDKMAHDLEIKW----TENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDRE 645
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVK 1494
+N + ++K++EDL + L +++ ++ + +Q + ER +L +EL
Sbjct: 646 KNAARD--SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 703
Query: 1495 ITESVSLNKQVAELN----KALEEEVAKTNEMQTALEN 1528
+ +K + E + + +EEE K Q ALEN
Sbjct: 704 EEQHQQRHKSLKEAHVLAFQTMEEEKEKE---QRALEN 738
Score = 71.3 bits (167), Expect = 3e-11
Identities = 182/930 (19%), Positives = 385/930 (41%), Gaps = 83/930 (8%)
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS 531
TE+++ K+Q L+ L D IK + + + ++ + ++ + +A + I S
Sbjct: 66 TEELDLRRKIQV-LESSLEDHIK--MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 122
Query: 532 NHKLKLKQ-MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
++++ ++ + +F ++ ++ RL E + + E++E + Q H +
Sbjct: 123 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR-QEIQELLKSQQDHSASVNK 181
Query: 591 GRMIESDVYKKMIEMEN--LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK---LA 645
G+ ++++ +E N L E RL+ L+E + L + +++ D ++ A
Sbjct: 182 GQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTA 241
Query: 646 DISQLQSDQVCSEIKSVHLEEQI--DALSASKKELALVIENLK--LDK-EQLYGTIKDLE 700
+ Q ++ K +E I + K EL +V + LDK ++L + E
Sbjct: 242 ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 301
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI--QTQFG-IDAKI 757
N+ + + +L + + M L K +++ +E ++ ++ + + + G + A
Sbjct: 302 NNVQVLQKQLDDAKEGEMALLSKHKEVESE-LAAARERLQQQASDLVLKASHIGMLQATQ 360
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
+++ I+++ESE S+ R+ +LEE A + + SL+ + Q L+ ++K
Sbjct: 361 MTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ--QILELEKKVNEAKR 418
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQHY 876
Q++ L L QL E + +EL K+ + +E + ++ D ++
Sbjct: 419 TQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHS--NAIRDKKKLQ 476
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQI 936
L E+ N+ D E K Q Q ++LE NLK + + Q+ ++D+ + +
Sbjct: 477 MDLEEQHNK-DKLNLEEDKNQLQ-QELE-NLKEVLEDKLNTANQEIGHLQDMVRKSEQGL 533
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI----DKH 992
SA L + E+ + + L+E K+ + N+ +E+ + + E I ++
Sbjct: 534 GSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE 593
Query: 993 VQKQQTQSPD----YTEQYINEINKLNALLKQKDEE--------IIALNQKINN-AQVSY 1039
K + D +TE E +KL L+ + EE ++ L + N A+ S+
Sbjct: 594 KLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSW 653
Query: 1040 MSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKE 1094
V D ++++ LE + +Q++ Q +Q +EL+ L + + K
Sbjct: 654 QKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKS 713
Query: 1095 LKETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
LKE L F+ + E + + + +++ E+E
Sbjct: 714 LKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTL 773
Query: 1154 RSVLQEQS----AKLNTELQECYTKII---------QLETLNTELTGHDVVNQEQ----- 1195
R L+++ A L +EL + I +L EL +++ Q
Sbjct: 774 RFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI 833
Query: 1196 --INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK------QHLAQRE 1247
I L+ +L L V L +IS+ + F+ E+ + Q + E
Sbjct: 834 CRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHE 893
Query: 1248 ADFQK-TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-----VTMEQVTSLQNKLQD 1301
D K E EL V ++A + + ++ + + T E +I V++E++ +
Sbjct: 894 QDLNKRLEKELDV-MTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRES 952
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
K E ++ + E A + + +I++ IED K
Sbjct: 953 KPEDIQMITELKAMLTERDQIIKKLIEDNK 982
>AL365275-1|CAI40383.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 102 bits (244), Expect = 1e-20
Identities = 203/1022 (19%), Positives = 432/1022 (42%), Gaps = 103/1022 (10%)
Query: 561 TEELH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
++E+H +S+K+A+L + L +++S D +++ I+ + LAETR K +
Sbjct: 37 SQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQ-QILAETREKILQYK 95
Query: 620 E--SQKFDLVQELHILQQKY-DEVEDKLADISQLQSD-------QVCSEIKSVH----LE 665
+++ DL +++ +L+ D ++ K +++ ++ Q+C+E + V +
Sbjct: 96 SKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 155
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYG-TIKDLE----NDKEDIMNKLQNY---IQEN 717
+++ + +E L++ E+ ++DL+ + ++++ Q++ + +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 215
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---ERDLYIENIESELSKY 774
+ ++L +M E ++++L ++ E + I+ G K Q ER+L S+L
Sbjct: 216 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK-RSQLFTA 274
Query: 775 KSRICRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+S E+ + ++ + L + +L + LQ Q + +L LA+
Sbjct: 275 ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 334
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
++ +V++KQL + + L K++ E L + +QQ + LV KA+ + ++
Sbjct: 335 NNVQVLQKQLDDAKEGEMALLSKHK---EVESELAAARERLQQQASDLVLKASHIGMLQA 391
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ ++DLES R+ L E E + TQ + +++L + +
Sbjct: 392 TQMTQEVTIKDLESEKSRVNERLSQL------EEERAFLRSKTQSLDEEQKQQILELEKK 445
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
N TQ E +E KN L V +LN+ + + +++ K I +
Sbjct: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
Query: 1012 NKLNA-LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
KL L +Q +++ + L + N Q ++ E KL ++ ++++ M R S+Q
Sbjct: 506 KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQD-MVRKSEQ 564
Query: 1071 -------LLDSKQHNEE-LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
L+ S Q ++E LQ + D +KE K+ L E + + E TI M
Sbjct: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETIAAMK 623
Query: 1123 DDAN-NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE-LQECYTKIIQLET 1180
++ VD L+++ E QE S L+E+ + E + ++++QL+
Sbjct: 624 EEEKLKVDKMAHD-------LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKD 676
Query: 1181 L--NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
N ++ +NQ+ + L + +++ +L++ + + E+ EL
Sbjct: 677 REKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 736
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
+QH Q+ K H L Q E + EQ ++++ Q++ + ++ SL
Sbjct: 737 EEQH--QQRHKSLKEAHVLAFQTMEEEKEKEQR--ALENHLQQKHSA-----ELQSL--- 784
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
K+ H +++ ++ +++ LR E+EDE A DL N
Sbjct: 785 ---KDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH 841
Query: 1359 YK----QMQEQSILNINEENAQ--------LKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
+ +M+ + ++I+ ++ L++ V + LT
Sbjct: 842 QELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALT 901
Query: 1407 HQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEY-------EKRIEDLTYEKESEL 1459
+LE K EI + E + + ++ ++ EK I + K +EL
Sbjct: 902 KELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNEL 961
Query: 1460 -----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
A L++ + E Y + +ES+ E +++I EL +TE + K++ E NK +
Sbjct: 962 LKEINAALQVSLEEMEEKY--LMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQL 1019
Query: 1515 EV 1516
E+
Sbjct: 1020 EL 1021
Score = 87.0 bits (206), Expect = 5e-16
Identities = 181/904 (20%), Positives = 370/904 (40%), Gaps = 85/904 (9%)
Query: 484 QLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
QL D +++++K + +K+ + I LN + D + +K H+ +++Q+
Sbjct: 28 QLAGHSMDYSQEMHLK-MSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQI--L 84
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
+ K+ ++ TEEL L +K+ LE +L+ H + + E + YK +
Sbjct: 85 AETREKILQYKSKV---TEELD-LRRKIQVLES---SLEDH-IKMKQQALTEFEAYKHRV 136
Query: 604 E-MENLAET----RLKAISL-LESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
E M+ AE R+ +S +E + ++L Q + E DK + LQ+
Sbjct: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR- 195
Query: 657 SEIKSVHLEEQIDALSASK-----KEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKL 710
EI+ + +Q + S +K +EL + +E+L E+L K L D E +NK
Sbjct: 196 REIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKA 255
Query: 711 QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK-IQERDLYIENIES 769
Q++ + +D + + +AE + K + + + Q Q I K I + ++ ++
Sbjct: 256 QSFYERELDTLKRSQLFTAESLQASKEK-EADLRKEFQGQEAILRKTIGKLKTELQMVQD 314
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLG----SYLQEKQKAYSEYTIQEDEL-- 823
E + +L+ ++A+ E+ L+++ D + L + ++ SE + L
Sbjct: 315 EAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ 374
Query: 824 --------VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQH 875
+ + +L E + ++E E + ++ L EE L+ + +
Sbjct: 375 QASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEE 434
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
+ + + + E++ T+ + R+L++ R+ E L K +E+L + +
Sbjct: 435 QKQQILELEKK-VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMA 493
Query: 936 IES----AIRDKKVLN-EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE-LNKMNLELI 989
IE+ AIRDKK L + E++ + LE + + +ENL +E+ LN N E+
Sbjct: 494 IEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEI- 552
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
H+Q +S I L ++ E+ + + + +++ + E +
Sbjct: 553 -GHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQE 611
Query: 1050 LAQFTTKLENM-EEEMQRVSKQLLD-----SKQHNEELQILVREQDDQIKELKETKLTFE 1103
Q + M EEE +V K D ++ +E L E Q +E K++ ++
Sbjct: 612 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQL 671
Query: 1104 MNIPKTEGMIISSTIEPMSDDA--------NNVDXXXXXXXXXXXXLKVQ---EEEEFIQ 1152
+ + E + + +D N++ L+ Q E + Q
Sbjct: 672 LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQ 731
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E L+EQ + + L+E + ++ +T+ E + + Q S +L + D
Sbjct: 732 ELEELEEQHQQRHKSLKEAH--VLAFQTMEEEKEKEQRALENHLQQKHSA--ELQSLKDA 787
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLA--------QREADFQKTEHELRVQLSAF 1264
++ R + + FE+ + K LA Q A H +L+A
Sbjct: 788 HRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 847
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
+ + E+ +D + ++E +I T LQ +L+ +E H+ L ++ + I L
Sbjct: 848 KMELERSIDISRRQSKEHICRI------TDLQEELRHREHHISELDKEVQHLHENISALT 901
Query: 1325 SEIE 1328
E+E
Sbjct: 902 KELE 905
Score = 72.1 bits (169), Expect = 2e-11
Identities = 130/740 (17%), Positives = 300/740 (40%), Gaps = 59/740 (7%)
Query: 819 QEDELVNRLAVLMD-HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+ DE + + L D H+ +++ L E + + + K L+ + +Q+ S ++ H
Sbjct: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHI- 119
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
K + L E E+ K++ + L + +H IV +E+E++ +F ++
Sbjct: 120 ----KMKQQALTEFEAYKHRVEDMQLCAEA-----QHVQRIVTMSREVEEIRRKFEEKLR 170
Query: 938 SA-------IRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
S +DK++ L + + + +L Q++ ++ EEL++M +E +
Sbjct: 171 SFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESL 230
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI----IALNQKINNAQVSYMSMVSD 1045
+K +++ + + E Y ++NK + +++ + + + + + ++ + +
Sbjct: 231 NKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKE 290
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQHNEELQIL----VREQDDQIKELKET 1098
++ + A + ++ E+Q V + LLD Q + + V+ Q+ + KE
Sbjct: 291 FQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEG 350
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE--EEFIQERSV 1156
++ + E + ++ E + A+++ QE ++ E+S
Sbjct: 351 EMALLSKHKEVESELAAAR-ERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSR 409
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDNLLS 1215
+ E+ ++L E +K ++L+ E + ++++N+ K ++ E E NL S
Sbjct: 410 VNERLSQLEEERAFLRSK---TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS 466
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+ E + ++ A + E+A WK H+A + ++Q+ E + L+
Sbjct: 467 RLEEEVTQLNEAHSKTLEELA--WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLE 524
Query: 1276 QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF- 1334
+ Q + E + N + HL+++ K + E L + ++D +
Sbjct: 525 EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 584
Query: 1335 --XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
++ E + +Q E++I + EE +LK
Sbjct: 585 NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE-KLKVDKMAHDLEIKW-- 641
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
+ + +L +L L+ E + L Q D +N + ++K++EDL
Sbjct: 642 --TENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARD--SWQKKVEDLL 694
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELN--- 1509
+ L +++ ++ + +Q + ER +L +EL + +K + E +
Sbjct: 695 NQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLA 754
Query: 1510 -KALEEEVAKTNEMQTALEN 1528
+ +EEE K Q ALEN
Sbjct: 755 FQTMEEEKEKE---QRALEN 771
Score = 71.7 bits (168), Expect = 2e-11
Identities = 183/931 (19%), Positives = 387/931 (41%), Gaps = 85/931 (9%)
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS 531
TE+++ K+Q L+ L D IK + + + ++ + ++ + +A + I S
Sbjct: 99 TEELDLRRKIQV-LESSLEDHIK--MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 155
Query: 532 NHKLKLKQ-MQKTIDNFSKVSDSNKEIVRLT-EELHHLSQKVAELEEEKGNLQLHLVDYD 589
++++ ++ + +F ++ ++ RL E+L ++ E++E + Q H +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRR--EIQELLKSQQDHSASVN 213
Query: 590 SGRMIESDVYKKMIEMEN--LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK---L 644
G+ ++++ +E N L E RL+ L+E + L + +++ D ++
Sbjct: 214 KGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFT 273
Query: 645 ADISQLQSDQVCSEIKSVHLEEQI--DALSASKKELALVIENLK--LDK-EQLYGTIKDL 699
A+ Q ++ K +E I + K EL +V + LDK ++L +
Sbjct: 274 AESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 333
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI--QTQFG-IDAK 756
EN+ + + +L + + M L K +++ +E ++ ++ + + + G + A
Sbjct: 334 ENNVQVLQKQLDDAKEGEMALLSKHKEVESE-LAAARERLQQQASDLVLKASHIGMLQAT 392
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY 816
+++ I+++ESE S+ R+ +LEE A + + SL+ + Q L+ ++K
Sbjct: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ--QILELEKKVNEAK 450
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQH 875
Q++ L L QL E + +EL K+ + +E + ++ D ++
Sbjct: 451 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHS--NAIRDKKKL 508
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
L E+ N+ D E K Q Q ++LE NLK + + Q+ ++D+ +
Sbjct: 509 QMDLEEQHNK-DKLNLEEDKNQLQ-QELE-NLKEVLEDKLNTANQEIGHLQDMVRKSEQG 565
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI----DK 991
+ SA L + E+ + + L+E K+ + N+ +E+ + + E I ++
Sbjct: 566 LGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEE 625
Query: 992 HVQKQQTQSPD----YTEQYINEINKLNALLKQKDEE--------IIALNQKINN-AQVS 1038
K + D +TE E +KL L+ + EE ++ L + N A+ S
Sbjct: 626 EKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 685
Query: 1039 YMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIK 1093
+ V D ++++ LE + +Q++ Q +Q +EL+ L + + K
Sbjct: 686 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 745
Query: 1094 ELKETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
LKE L F+ + E + + + +++ E+E
Sbjct: 746 SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 805
Query: 1153 ERSVLQEQS----AKLNTELQECYTKII---------QLETLNTELTGHDVVNQEQ---- 1195
R L+++ A L +EL + I +L EL +++ Q
Sbjct: 806 LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEH 865
Query: 1196 ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK------QHLAQR 1246
I L+ +L L V L +IS+ + F+ E+ + Q +
Sbjct: 866 ICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLH 925
Query: 1247 EADFQK-TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-----VTMEQVTSLQNKLQ 1300
E D K E EL V ++A + + ++ + + T E +I V++E++ +
Sbjct: 926 EQDLNKRLEKELDV-MTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRE 984
Query: 1301 DKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
K E ++ + E A + + +I++ IED K
Sbjct: 985 SKPEDIQMITELKAMLTERDQIIKKLIEDNK 1015
>AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1007
Score = 102 bits (244), Expect = 1e-20
Identities = 164/842 (19%), Positives = 376/842 (44%), Gaps = 68/842 (8%)
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEE-EKGNLQLHLVD 587
++++ + K+M++ N + K + EELH QK + ++ GN++ + +
Sbjct: 14 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 73
Query: 588 YDSGRMIESDVYKKMI-EMENLAETRLKAIS-LLESQKF--DLVQELHILQQKYD-EVED 642
+ + ++ ++ ++ E+E + +T LK S L E+ + + EL ++K V
Sbjct: 74 LEIEKSLKH--HEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKVCLLVVW 131
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE--QLYGTIKDLE 700
++ + + + ++ K L+ + DA ++ + +K D++ L KDLE
Sbjct: 132 GVSSVWTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLE 191
Query: 701 NDK---EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
K E+I+ ++ N I D + EK++E L K+ + + + + +
Sbjct: 192 QHKIKQEEILKEI-NKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVL 250
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSE 815
+E ++ ++ +EL K KS++ ++ +AV+ DR+ +++ L GS +Q K
Sbjct: 251 KESEVLLQAKRAELEKLKSQVTSQQQEMAVL-DRQLGHKKEELHLLQGSMVQAKADLQEA 309
Query: 816 YTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL-----QKKNQILL------EENQN 864
+ E E+ + +H R V+ L E+ + EL ++K Q+ L +E +N
Sbjct: 310 LRLGETEVTEK----CNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEEN 365
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE 924
LQ+ L M +H E N D+ + E+ + Q + + + + Q ++++K E
Sbjct: 366 LQVVLRQMSKH---KTELKNILDMLQLENHELQGLKLQHDQRVSEL-EKTQVAVLEEKLE 421
Query: 925 IEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM 984
+E+L+ + + Q + I +K L E+ ++ IE +T A+ + ++ +E L+ E+L +
Sbjct: 422 LENLQ-QISQQQKGEIEWQKQLLERDKREIERMT---AESRALQSCVECLSKEKEDLQE- 476
Query: 985 NLELIDKHVQKQQ---TQSPDYTEQYINEINKLNALLKQKDEEIIALNQ---KINNAQVS 1038
++ +K + + + + + ++ + + KL +++ +E+ LN+ ++N +
Sbjct: 477 KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISA 536
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
+ + + +L N+++ + + LL + +H + +L+ EQ K++ E
Sbjct: 537 MQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQD---VLLSEQTRLQKDISEW 593
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV-L 1157
FE + E + + N + + + EE ++ V L
Sbjct: 594 ANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL 653
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
+EQ +L EL + +K+ Q+ L+ L +E++ L+ + + L T
Sbjct: 654 KEQQHQLEKELTDQKSKLDQV--LSKVLAA-----EERVRTLQEEERWCESLEKTLSQTK 706
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ- 1276
+L V++ G E+ L K+ + R ADF ++ + E + L ++++
Sbjct: 707 RQLSEREQQLVEKSG-ELLALQKEADSMR-ADFSLLRNQFLTERKKAEKQVASLKEALKI 764
Query: 1277 SSTQEETNKIVTMEQVTSLQNKL-------QDKEEHLRNLQEKYADVINQIEILRSEIED 1329
+Q E N + ++ + +Q ++ QD E R L ++ + + L+ ++ +
Sbjct: 765 QRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN 824
Query: 1330 EK 1331
+K
Sbjct: 825 QK 826
Score = 89.8 bits (213), Expect = 7e-17
Identities = 152/804 (18%), Positives = 335/804 (41%), Gaps = 53/804 (6%)
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYS---LERKADQLGSYLQ-EKQKAYSEYTIQED 821
NI+ L + KS C +EE ++ R+ ++ + L + L+ EK + E + E
Sbjct: 31 NIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI 90
Query: 822 ELVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA-- 878
E + + + + R ++ L E E E ++K +L+ + + + +++ +A
Sbjct: 91 ECIEKTLLKRRSELREADRLLAEAESELSCTKEKVCLLVVWGVSSVWTKNAVEKFTDAKR 150
Query: 879 -LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
L++ + + E + + L + L+ + + + L K K+ E L+ E N +
Sbjct: 151 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK-EINKIVA 209
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
+ D + L++K EK E + +L+ ++ + N ++ +++ L + + L K + ++
Sbjct: 210 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDH---HLQVLKESEVLLQAKRAELEK 266
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+S ++Q E+ L+ L K EE+ L Q S + +D + L T++
Sbjct: 267 LKSQVTSQQ--QEMAVLDRQLGHKKEELHLL-------QGSMVQAKADLQEALRLGETEV 317
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
++ V L + EL + + E+ Q+ +K+ E N+ ++
Sbjct: 318 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL-----QVVLRQ 372
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
+ + N+ LK+Q ++ + + + Q A L +L+ +
Sbjct: 373 MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSE---LEKTQVAVLEEKLE-----LEN 424
Query: 1178 LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
L+ ++ + G ++ + + K ++E++ E+ L S V E S + ++ +
Sbjct: 425 LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV-ECLSKEKEDLQEK----CD 479
Query: 1238 LWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN 1297
+W++ LAQ + E +++ S E + Q Q +K+ ++++Q
Sbjct: 480 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ 539
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEI------EDEKVAFXXXXXXXXXXXXXXXXD 1351
+LQ+K E + +LQE+ A+V + + + + ++ +D ++ D
Sbjct: 540 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 599
Query: 1352 LRTENQSYKQMQEQSILNINEEN----AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
+ E ++ KQ Q Q + N EEN Q + ++ ++ + E H
Sbjct: 600 CQKEEET-KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQH 658
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
QLE K+ + + ++ +E Q+ + + +E + + +L+ ++
Sbjct: 659 QLE-KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLV 717
Query: 1468 ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--EEEVAKTNEMQTA 1525
E + +QKE++ R N +TE KQVA L +AL + + N ++
Sbjct: 718 EKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQK 777
Query: 1526 LENQEIEIVTLNDEITNLQNMVRA 1549
EN I+ E+ N RA
Sbjct: 778 QENSCIQKEMATIELVAQDNHERA 801
Score = 79.8 bits (188), Expect = 7e-14
Identities = 189/975 (19%), Positives = 393/975 (40%), Gaps = 100/975 (10%)
Query: 249 RISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXL-AKQSIEPSCEEK 307
R S L EA++LL A E+S K+ + AK+S+ + +
Sbjct: 100 RRSELREADRLLAEAESELSCTKEKVCLLVVWGVSSVWTKNAVEKFTDAKRSLLQTESDA 159
Query: 308 TEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS 367
E+E + N+ + +++ L+ + Q + E L E + +
Sbjct: 160 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK----EINKIVAAKDSDF 215
Query: 368 PLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVD-KEY 426
+S+K + T K + N+D ++ K E+++Q+ +L K
Sbjct: 216 QCLSKKKEKLTEELQKLQ-KDIEMAERNEDHHLQVLKES----EVLLQAKRAELEKLKSQ 270
Query: 427 VISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTN--TEDVNEIAKVQEQ 484
V S++ K+ L Q + + +G TE N I +V+
Sbjct: 271 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSL 330
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM---IKVKSNHKLKLKQMQ 541
L +EL+ + ++NV+ + + Q+T + EI+ +N+ ++ S HK +LK +
Sbjct: 331 L-EELSFQKGELNVQ-----ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI- 383
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
+ N E+ L +L H Q+V+ELE+ + V ++
Sbjct: 384 -----LDMLQLENHELQGL--KLQH-DQRVSELEKT-----------------QVAVLEE 418
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
+E+ENL + + + QK ++ + +L++ E+E A+ LQS C +
Sbjct: 419 KLELENLQQ-------ISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEK 471
Query: 662 VHLEEQID----ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
L+E+ D L+ +K+ LA EN K+++ L + LE + + +L ++
Sbjct: 472 EDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNL----EKLELNVRKLQQELDQLNRDK 527
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
+ L + + M +++ E +N ++ Q ++ + ++DL L K +
Sbjct: 528 LSLHNDISAMQ-QQLQEKREAVNSLQEELANVQDHLN--LAKQDL--------LHTTKHQ 576
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
L E + +D + A++ +E++ + + ++E+ L+ + +
Sbjct: 577 DVLLSEQTRLQKD----ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 632
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK---ANRTDLAESEST 894
++ E E E +L+ L E+ L+ L+D + + ++ K A E
Sbjct: 633 QRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEE 692
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKN 953
++ L S KR E + +V+K E+ L+ E ++ + + ++ + L E+ +K
Sbjct: 693 RWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER-KKA 751
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
+ V L+ L+ ++ +E N+ E + N I K + + + D E+ + +
Sbjct: 752 EKQVASLKEALKIQRSQLEK---NLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKE 807
Query: 1014 LNALLKQKDE--EIIALNQKINNAQVSYMSMVSDYESKLA-QFTTKLENMEEEMQRVSKQ 1070
LN + + E + +A + + Q+ + +S++ + T L+N+ + + +
Sbjct: 808 LNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPAD 867
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
L + NE L + +++ LKE L F MN E + S + M D+ +
Sbjct: 868 LEAILERNENL-------EGELESLKE-NLPFTMNEGPFEEKLNFSQVHIM-DEHWRGEA 918
Query: 1131 XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV 1190
LK Q ++ VL + + L ++ L L T T D
Sbjct: 919 LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADS 977
Query: 1191 VNQEQINQLKSKLEQ 1205
+ ++QL+S L +
Sbjct: 978 ASSPSLSQLESSLTE 992
Score = 67.7 bits (158), Expect = 3e-10
Identities = 138/696 (19%), Positives = 296/696 (42%), Gaps = 67/696 (9%)
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
+LK E + + K++ +++E E + I+ +++KK L + E+ V + + Q
Sbjct: 3 HLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKD 61
Query: 966 EYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
N+E+L + +E+ K + +++D+ ++T + +E+ + + LL + +
Sbjct: 62 FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL-----KRRSELREADRLLAEAES 116
Query: 1024 EIIALNQKINNAQVSYMSMV---------SDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
E+ +K+ V +S V +D + L Q + E +E Q + L+ +
Sbjct: 117 ELSCTKEKVCLLVVWGVSSVWTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 176
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMN----IPKTEGMIISSTIEPMSDDANNV-- 1128
Q LQ ++ + ++K+ ++ E+N ++ +S E ++++ +
Sbjct: 177 DQQLRSLQADAKDLEQH--KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 234
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL-- 1185
D ++E E +Q +R+ L++ +++ ++ QE QL EL
Sbjct: 235 DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL 294
Query: 1186 -TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
G V + + + E TE N + V L +S + +I+E K L
Sbjct: 295 LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER-KTQLT 353
Query: 1245 QREADFQKTEHELRV---QLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNK-- 1298
+ + +K E L+V Q+S +++ + +LD +Q E + K+ ++V+ L+
Sbjct: 354 LIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQV 413
Query: 1299 --LQDKEEHLRNLQEKYADVINQIEILRSEIEDEK------VAFXXXXXXXXXXXXXXXX 1350
L++K E L NLQ+ +IE + +E +K A
Sbjct: 414 AVLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKE 472
Query: 1351 DLRTENQSY--KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTH 1407
DL+ + + K Q + +L EEN+++++S+ + ++ L L +
Sbjct: 473 DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN 532
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE---SELAILRL 1464
+ ++ +K + +E NV+ L ++ + T ++ SE L+
Sbjct: 533 DISAMQQQLQEKRE----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK 588
Query: 1465 KMHENANHYETMQKESEIERVKL------IEELNVKITESVSLNKQVAELNKALEEEVAK 1518
+ E AN +E QKE E ++ +L IEE +K+ + + ++ L K E E +K
Sbjct: 589 DISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR---LQKERESEESK 645
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ L+ Q+ + L E+T+ ++ + SK+
Sbjct: 646 LETSKVTLKEQQHQ---LEKELTDQKSKLDQVLSKV 678
Score = 66.9 bits (156), Expect = 6e-10
Identities = 150/784 (19%), Positives = 332/784 (42%), Gaps = 71/784 (9%)
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR--TDLAESE 892
R EK++ E+ H +L ++ + L E + L ++ QQ + + T+L +
Sbjct: 19 RQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK 78
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN-TQIESAIRDKKVLNEKYE 951
S K+ + D +++ + ++ + + + + + E E + T+ + + ++ +
Sbjct: 79 SLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKVCLLVVWGVSSVWT 138
Query: 952 KN-IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT------ 1004
KN +E T + L + +++ E L +E +NL D+ ++ Q + D
Sbjct: 139 KNAVEKFTDAKRSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQADAKDLEQHKIKQ 197
Query: 1005 EQYINEINKLNA--------LLKQKD---EEIIALNQKINNAQVS---YMSMVSDYESKL 1050
E+ + EINK+ A L K+K+ EE+ L + I A+ + ++ ++ + E L
Sbjct: 198 EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLL 257
Query: 1051 AQFTTKLENMEEEM--QRVSKQLLDSK--QHNEELQILVREQDDQIKELKETKLTFEMNI 1106
+LE ++ ++ Q+ +LD + EEL +L +L+E E +
Sbjct: 258 QAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEV 317
Query: 1107 PKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEEFIQERSVLQEQSA 1162
+ I + S +E +S ++ +K +++EEE +Q V+ Q +
Sbjct: 318 TEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ---VVLRQMS 374
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRS 1222
K TEL+ ++QLE N EL G + + +++++L+ Q+ + L EL +
Sbjct: 375 KHKTELKNILD-MLQLE--NHELQGLKLQHDQRVSELEKT--QVAVLEEKL-----ELEN 424
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREA-DFQKTEHELRVQLSAFE--SKYEQLLDS---VQ 1276
+ Q+G EI W++ L +R+ + ++ E R S E SK ++ L +
Sbjct: 425 LQQISQQQKG-EIE--WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIW 481
Query: 1277 SSTQEETNKIVTMEQVTSL--QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF 1334
+T +++ + S Q+ L+ E ++R LQ++ D +N+ ++ + ++ A
Sbjct: 482 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL-DQLNRDKL---SLHNDISAM 537
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
+L Q + + +Q +L+ + L R
Sbjct: 538 QQQLQEKREAVNSLQEELANV-QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANR 596
Query: 1395 VNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
D + + QL++ +EI E + L Q+ F+ ++++ E ++E
Sbjct: 597 FEDCQKEEETKQQQLQVLQNEI----EENKLKLVQQEMMFQRLQKERESEESKLETSKVT 652
Query: 1455 KESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
+ + L ++ + + + + + + ERV+ ++E + ES L K +++ + L
Sbjct: 653 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE-EERWCES--LEKTLSQTKRQL 709
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
E + E L + E ++ + + L+N K +K V+ + + + QL
Sbjct: 710 SEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQL 769
Query: 1573 DNTM 1576
+ +
Sbjct: 770 EKNL 773
>AL137009-1|CAI20344.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 102 bits (244), Expect = 1e-20
Identities = 203/1022 (19%), Positives = 432/1022 (42%), Gaps = 103/1022 (10%)
Query: 561 TEELH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
++E+H +S+K+A+L + L +++S D +++ I+ + LAETR K +
Sbjct: 37 SQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQ-QILAETREKILQYK 95
Query: 620 E--SQKFDLVQELHILQQKY-DEVEDKLADISQLQSD-------QVCSEIKSVH----LE 665
+++ DL +++ +L+ D ++ K +++ ++ Q+C+E + V +
Sbjct: 96 SKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 155
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYG-TIKDLE----NDKEDIMNKLQNY---IQEN 717
+++ + +E L++ E+ ++DL+ + ++++ Q++ + +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 215
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---ERDLYIENIESELSKY 774
+ ++L +M E ++++L ++ E + I+ G K Q ER+L S+L
Sbjct: 216 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK-RSQLFTA 274
Query: 775 KSRICRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+S E+ + ++ + L + +L + LQ Q + +L LA+
Sbjct: 275 ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 334
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
++ +V++KQL + + L K++ E L + +QQ + LV KA+ + ++
Sbjct: 335 NNVQVLQKQLDDAKEGEMALLSKHK---EVESELAAARERLQQQASDLVLKASHIGMLQA 391
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ ++DLES R+ L E E + TQ + +++L + +
Sbjct: 392 TQMTQEVTIKDLESEKSRVNERLSQL------EEERAFLRSKTQSLDEEQKQQILELEKK 445
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
N TQ E +E KN L V +LN+ + + +++ K I +
Sbjct: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
Query: 1012 NKLNA-LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
KL L +Q +++ + L + N Q ++ E KL ++ ++++ M R S+Q
Sbjct: 506 KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQD-MVRKSEQ 564
Query: 1071 -------LLDSKQHNEE-LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
L+ S Q ++E LQ + D +KE K+ L E + + E TI M
Sbjct: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETIAAMK 623
Query: 1123 DDAN-NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE-LQECYTKIIQLET 1180
++ VD L+++ E QE S L+E+ + E + ++++QL+
Sbjct: 624 EEEKLKVDKMAHD-------LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKD 676
Query: 1181 L--NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
N ++ +NQ+ + L + +++ +L++ + + E+ EL
Sbjct: 677 REKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 736
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
+QH Q+ K H L Q E + EQ ++++ Q++ + ++ SL
Sbjct: 737 EEQH--QQRHKSLKEAHVLAFQTMEEEKEKEQR--ALENHLQQKHSA-----ELQSL--- 784
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
K+ H +++ ++ +++ LR E+EDE A DL N
Sbjct: 785 ---KDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH 841
Query: 1359 YK----QMQEQSILNINEENAQ--------LKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
+ +M+ + ++I+ ++ L++ V + LT
Sbjct: 842 QELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALT 901
Query: 1407 HQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEY-------EKRIEDLTYEKESEL 1459
+LE K EI + E + + ++ ++ EK I + K +EL
Sbjct: 902 KELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNEL 961
Query: 1460 -----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
A L++ + E Y + +ES+ E +++I EL +TE + K++ E NK +
Sbjct: 962 LKEINAALQVSLEEMEEKY--LMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQL 1019
Query: 1515 EV 1516
E+
Sbjct: 1020 EL 1021
Score = 87.0 bits (206), Expect = 5e-16
Identities = 181/904 (20%), Positives = 370/904 (40%), Gaps = 85/904 (9%)
Query: 484 QLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
QL D +++++K + +K+ + I LN + D + +K H+ +++Q+
Sbjct: 28 QLAGHSMDYSQEMHLK-MSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQI--L 84
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
+ K+ ++ TEEL L +K+ LE +L+ H + + E + YK +
Sbjct: 85 AETREKILQYKSKV---TEELD-LRRKIQVLES---SLEDH-IKMKQQALTEFEAYKHRV 136
Query: 604 E-MENLAET----RLKAISL-LESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
E M+ AE R+ +S +E + ++L Q + E DK + LQ+
Sbjct: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR- 195
Query: 657 SEIKSVHLEEQIDALSASK-----KEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKL 710
EI+ + +Q + S +K +EL + +E+L E+L K L D E +NK
Sbjct: 196 REIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKA 255
Query: 711 QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK-IQERDLYIENIES 769
Q++ + +D + + +AE + K + + + Q Q I K I + ++ ++
Sbjct: 256 QSFYERELDTLKRSQLFTAESLQASKEK-EADLRKEFQGQEAILRKTIGKLKTELQMVQD 314
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLG----SYLQEKQKAYSEYTIQEDEL-- 823
E + +L+ ++A+ E+ L+++ D + L + ++ SE + L
Sbjct: 315 EAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ 374
Query: 824 --------VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQH 875
+ + +L E + ++E E + ++ L EE L+ + +
Sbjct: 375 QASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEE 434
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
+ + + + E++ T+ + R+L++ R+ E L K +E+L + +
Sbjct: 435 QKQQILELEKK-VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMA 493
Query: 936 IES----AIRDKKVLN-EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE-LNKMNLELI 989
IE+ AIRDKK L + E++ + LE + + +ENL +E+ LN N E+
Sbjct: 494 IEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEI- 552
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
H+Q +S I L ++ E+ + + + +++ + E +
Sbjct: 553 -GHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQE 611
Query: 1050 LAQFTTKLENM-EEEMQRVSKQLLD-----SKQHNEELQILVREQDDQIKELKETKLTFE 1103
Q + M EEE +V K D ++ +E L E Q +E K++ ++
Sbjct: 612 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQL 671
Query: 1104 MNIPKTEGMIISSTIEPMSDDA--------NNVDXXXXXXXXXXXXLKVQ---EEEEFIQ 1152
+ + E + + +D N++ L+ Q E + Q
Sbjct: 672 LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQ 731
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E L+EQ + + L+E + ++ +T+ E + + Q S +L + D
Sbjct: 732 ELEELEEQHQQRHKSLKEAH--VLAFQTMEEEKEKEQRALENHLQQKHSA--ELQSLKDA 787
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLA--------QREADFQKTEHELRVQLSAF 1264
++ R + + FE+ + K LA Q A H +L+A
Sbjct: 788 HRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 847
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
+ + E+ +D + ++E +I T LQ +L+ +E H+ L ++ + I L
Sbjct: 848 KMELERSIDISRRQSKEHICRI------TDLQEELRHREHHISELDKEVQHLHENISALT 901
Query: 1325 SEIE 1328
E+E
Sbjct: 902 KELE 905
Score = 72.1 bits (169), Expect = 2e-11
Identities = 130/740 (17%), Positives = 300/740 (40%), Gaps = 59/740 (7%)
Query: 819 QEDELVNRLAVLMD-HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+ DE + + L D H+ +++ L E + + + K L+ + +Q+ S ++ H
Sbjct: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHI- 119
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
K + L E E+ K++ + L + +H IV +E+E++ +F ++
Sbjct: 120 ----KMKQQALTEFEAYKHRVEDMQLCAEA-----QHVQRIVTMSREVEEIRRKFEEKLR 170
Query: 938 SA-------IRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
S +DK++ L + + + +L Q++ ++ EEL++M +E +
Sbjct: 171 SFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESL 230
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI----IALNQKINNAQVSYMSMVSD 1045
+K +++ + + E Y ++NK + +++ + + + + + ++ + +
Sbjct: 231 NKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKE 290
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQHNEELQIL----VREQDDQIKELKET 1098
++ + A + ++ E+Q V + LLD Q + + V+ Q+ + KE
Sbjct: 291 FQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEG 350
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE--EEFIQERSV 1156
++ + E + ++ E + A+++ QE ++ E+S
Sbjct: 351 EMALLSKHKEVESELAAAR-ERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSR 409
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDNLLS 1215
+ E+ ++L E +K ++L+ E + ++++N+ K ++ E E NL S
Sbjct: 410 VNERLSQLEEERAFLRSK---TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS 466
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+ E + ++ A + E+A WK H+A + ++Q+ E + L+
Sbjct: 467 RLEEEVTQLNEAHSKTLEELA--WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLE 524
Query: 1276 QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF- 1334
+ Q + E + N + HL+++ K + E L + ++D +
Sbjct: 525 EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 584
Query: 1335 --XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
++ E + +Q E++I + EE +LK
Sbjct: 585 NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE-KLKVDKMAHDLEIKW-- 641
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
+ + +L +L L+ E + L Q D +N + ++K++EDL
Sbjct: 642 --TENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARD--SWQKKVEDLL 694
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELN--- 1509
+ L +++ ++ + +Q + ER +L +EL + +K + E +
Sbjct: 695 NQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLA 754
Query: 1510 -KALEEEVAKTNEMQTALEN 1528
+ +EEE K Q ALEN
Sbjct: 755 FQTMEEEKEKE---QRALEN 771
Score = 71.7 bits (168), Expect = 2e-11
Identities = 183/931 (19%), Positives = 387/931 (41%), Gaps = 85/931 (9%)
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS 531
TE+++ K+Q L+ L D IK + + + ++ + ++ + +A + I S
Sbjct: 99 TEELDLRRKIQV-LESSLEDHIK--MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 155
Query: 532 NHKLKLKQ-MQKTIDNFSKVSDSNKEIVRLT-EELHHLSQKVAELEEEKGNLQLHLVDYD 589
++++ ++ + +F ++ ++ RL E+L ++ E++E + Q H +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRR--EIQELLKSQQDHSASVN 213
Query: 590 SGRMIESDVYKKMIEMEN--LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK---L 644
G+ ++++ +E N L E RL+ L+E + L + +++ D ++
Sbjct: 214 KGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFT 273
Query: 645 ADISQLQSDQVCSEIKSVHLEEQI--DALSASKKELALVIENLK--LDK-EQLYGTIKDL 699
A+ Q ++ K +E I + K EL +V + LDK ++L +
Sbjct: 274 AESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 333
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI--QTQFG-IDAK 756
EN+ + + +L + + M L K +++ +E ++ ++ + + + G + A
Sbjct: 334 ENNVQVLQKQLDDAKEGEMALLSKHKEVESE-LAAARERLQQQASDLVLKASHIGMLQAT 392
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY 816
+++ I+++ESE S+ R+ +LEE A + + SL+ + Q L+ ++K
Sbjct: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ--QILELEKKVNEAK 450
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQH 875
Q++ L L QL E + +EL K+ + +E + ++ D ++
Sbjct: 451 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHS--NAIRDKKKL 508
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
L E+ N+ D E K Q Q ++LE NLK + + Q+ ++D+ +
Sbjct: 509 QMDLEEQHNK-DKLNLEEDKNQLQ-QELE-NLKEVLEDKLNTANQEIGHLQDMVRKSEQG 565
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI----DK 991
+ SA L + E+ + + L+E K+ + N+ +E+ + + E I ++
Sbjct: 566 LGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEE 625
Query: 992 HVQKQQTQSPD----YTEQYINEINKLNALLKQKDEE--------IIALNQKINN-AQVS 1038
K + D +TE E +KL L+ + EE ++ L + N A+ S
Sbjct: 626 EKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 685
Query: 1039 YMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIK 1093
+ V D ++++ LE + +Q++ Q +Q +EL+ L + + K
Sbjct: 686 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 745
Query: 1094 ELKETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
LKE L F+ + E + + + +++ E+E
Sbjct: 746 SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 805
Query: 1153 ERSVLQEQS----AKLNTELQECYTKII---------QLETLNTELTGHDVVNQEQ---- 1195
R L+++ A L +EL + I +L EL +++ Q
Sbjct: 806 LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEH 865
Query: 1196 ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK------QHLAQR 1246
I L+ +L L V L +IS+ + F+ E+ + Q +
Sbjct: 866 ICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLH 925
Query: 1247 EADFQK-TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-----VTMEQVTSLQNKLQ 1300
E D K E EL V ++A + + ++ + + T E +I V++E++ +
Sbjct: 926 EQDLNKRLEKELDV-MTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRE 984
Query: 1301 DKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
K E ++ + E A + + +I++ IED K
Sbjct: 985 SKPEDIQMITELKAMLTERDQIIKKLIEDNK 1015
>AL132874-2|CAI42604.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 102 bits (244), Expect = 1e-20
Identities = 203/1022 (19%), Positives = 432/1022 (42%), Gaps = 103/1022 (10%)
Query: 561 TEELH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
++E+H +S+K+A+L + L +++S D +++ I+ + LAETR K +
Sbjct: 37 SQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQ-QILAETREKILQYK 95
Query: 620 E--SQKFDLVQELHILQQKY-DEVEDKLADISQLQSD-------QVCSEIKSVH----LE 665
+++ DL +++ +L+ D ++ K +++ ++ Q+C+E + V +
Sbjct: 96 SKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 155
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYG-TIKDLE----NDKEDIMNKLQNY---IQEN 717
+++ + +E L++ E+ ++DL+ + ++++ Q++ + +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 215
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---ERDLYIENIESELSKY 774
+ ++L +M E ++++L ++ E + I+ G K Q ER+L S+L
Sbjct: 216 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK-RSQLFTA 274
Query: 775 KSRICRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+S E+ + ++ + L + +L + LQ Q + +L LA+
Sbjct: 275 ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 334
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
++ +V++KQL + + L K++ E L + +QQ + LV KA+ + ++
Sbjct: 335 NNVQVLQKQLDDAKEGEMALLSKHK---EVESELAAARERLQQQASDLVLKASHIGMLQA 391
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
+ ++DLES R+ L E E + TQ + +++L + +
Sbjct: 392 TQMTQEVTIKDLESEKSRVNERLSQL------EEERAFLRSKTQSLDEEQKQQILELEKK 445
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
N TQ E +E KN L V +LN+ + + +++ K I +
Sbjct: 446 VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 505
Query: 1012 NKLNA-LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
KL L +Q +++ + L + N Q ++ E KL ++ ++++ M R S+Q
Sbjct: 506 KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQD-MVRKSEQ 564
Query: 1071 -------LLDSKQHNEE-LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
L+ S Q ++E LQ + D +KE K+ L E + + E TI M
Sbjct: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETIAAMK 623
Query: 1123 DDAN-NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE-LQECYTKIIQLET 1180
++ VD L+++ E QE S L+E+ + E + ++++QL+
Sbjct: 624 EEEKLKVDKMAHD-------LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKD 676
Query: 1181 L--NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
N ++ +NQ+ + L + +++ +L++ + + E+ EL
Sbjct: 677 REKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 736
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK 1298
+QH Q+ K H L Q E + EQ ++++ Q++ + ++ SL
Sbjct: 737 EEQH--QQRHKSLKEAHVLAFQTMEEEKEKEQR--ALENHLQQKHSA-----ELQSL--- 784
Query: 1299 LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS 1358
K+ H +++ ++ +++ LR E+EDE A DL N
Sbjct: 785 ---KDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH 841
Query: 1359 YK----QMQEQSILNINEENAQ--------LKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
+ +M+ + ++I+ ++ L++ V + LT
Sbjct: 842 QELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALT 901
Query: 1407 HQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEY-------EKRIEDLTYEKESEL 1459
+LE K EI + E + + ++ ++ EK I + K +EL
Sbjct: 902 KELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNEL 961
Query: 1460 -----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
A L++ + E Y + +ES+ E +++I EL +TE + K++ E NK +
Sbjct: 962 LKEINAALQVSLEEMEEKY--LMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQL 1019
Query: 1515 EV 1516
E+
Sbjct: 1020 EL 1021
Score = 87.0 bits (206), Expect = 5e-16
Identities = 181/904 (20%), Positives = 370/904 (40%), Gaps = 85/904 (9%)
Query: 484 QLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT 543
QL D +++++K + +K+ + I LN + D + +K H+ +++Q+
Sbjct: 28 QLAGHSMDYSQEMHLK-MSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQI--L 84
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
+ K+ ++ TEEL L +K+ LE +L+ H + + E + YK +
Sbjct: 85 AETREKILQYKSKV---TEELD-LRRKIQVLES---SLEDH-IKMKQQALTEFEAYKHRV 136
Query: 604 E-MENLAET----RLKAISL-LESQKFDLVQELHILQQKYDEVE-DKLADISQLQSDQVC 656
E M+ AE R+ +S +E + ++L Q + E DK + LQ+
Sbjct: 137 EDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR- 195
Query: 657 SEIKSVHLEEQIDALSASK-----KEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKL 710
EI+ + +Q + S +K +EL + +E+L E+L K L D E +NK
Sbjct: 196 REIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKA 255
Query: 711 QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK-IQERDLYIENIES 769
Q++ + +D + + +AE + K + + + Q Q I K I + ++ ++
Sbjct: 256 QSFYERELDTLKRSQLFTAESLQASKEK-EADLRKEFQGQEAILRKTIGKLKTELQMVQD 314
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLG----SYLQEKQKAYSEYTIQEDEL-- 823
E + +L+ ++A+ E+ L+++ D + L + ++ SE + L
Sbjct: 315 EAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ 374
Query: 824 --------VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQH 875
+ + +L E + ++E E + ++ L EE L+ + +
Sbjct: 375 QASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEE 434
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
+ + + + E++ T+ + R+L++ R+ E L K +E+L + +
Sbjct: 435 QKQQILELEKK-VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMA 493
Query: 936 IES----AIRDKKVLN-EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE-LNKMNLELI 989
IE+ AIRDKK L + E++ + LE + + +ENL +E+ LN N E+
Sbjct: 494 IEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEI- 552
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
H+Q +S I L ++ E+ + + + +++ + E +
Sbjct: 553 -GHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQE 611
Query: 1050 LAQFTTKLENM-EEEMQRVSKQLLD-----SKQHNEELQILVREQDDQIKELKETKLTFE 1103
Q + M EEE +V K D ++ +E L E Q +E K++ ++
Sbjct: 612 RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQL 671
Query: 1104 MNIPKTEGMIISSTIEPMSDDA--------NNVDXXXXXXXXXXXXLKVQ---EEEEFIQ 1152
+ + E + + +D N++ L+ Q E + Q
Sbjct: 672 LQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQ 731
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E L+EQ + + L+E + ++ +T+ E + + Q S +L + D
Sbjct: 732 ELEELEEQHQQRHKSLKEAH--VLAFQTMEEEKEKEQRALENHLQQKHSA--ELQSLKDA 787
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLA--------QREADFQKTEHELRVQLSAF 1264
++ R + + FE+ + K LA Q A H +L+A
Sbjct: 788 HRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 847
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
+ + E+ +D + ++E +I T LQ +L+ +E H+ L ++ + I L
Sbjct: 848 KMELERSIDISRRQSKEHICRI------TDLQEELRHREHHISELDKEVQHLHENISALT 901
Query: 1325 SEIE 1328
E+E
Sbjct: 902 KELE 905
Score = 72.1 bits (169), Expect = 2e-11
Identities = 130/740 (17%), Positives = 300/740 (40%), Gaps = 59/740 (7%)
Query: 819 QEDELVNRLAVLMD-HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
+ DE + + L D H+ +++ L E + + + K L+ + +Q+ S ++ H
Sbjct: 61 KNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHI- 119
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
K + L E E+ K++ + L + +H IV +E+E++ +F ++
Sbjct: 120 ----KMKQQALTEFEAYKHRVEDMQLCAEA-----QHVQRIVTMSREVEEIRRKFEEKLR 170
Query: 938 SA-------IRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
S +DK++ L + + + +L Q++ ++ EEL++M +E +
Sbjct: 171 SFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESL 230
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI----IALNQKINNAQVSYMSMVSD 1045
+K +++ + + E Y ++NK + +++ + + + + + ++ + +
Sbjct: 231 NKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKE 290
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQHNEELQIL----VREQDDQIKELKET 1098
++ + A + ++ E+Q V + LLD Q + + V+ Q+ + KE
Sbjct: 291 FQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEG 350
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE--EEFIQERSV 1156
++ + E + ++ E + A+++ QE ++ E+S
Sbjct: 351 EMALLSKHKEVESELAAAR-ERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSR 409
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDNLLS 1215
+ E+ ++L E +K ++L+ E + ++++N+ K ++ E E NL S
Sbjct: 410 VNERLSQLEEERAFLRSK---TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS 466
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+ E + ++ A + E+A WK H+A + ++Q+ E + L+
Sbjct: 467 RLEEEVTQLNEAHSKTLEELA--WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLE 524
Query: 1276 QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF- 1334
+ Q + E + N + HL+++ K + E L + ++D +
Sbjct: 525 EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 584
Query: 1335 --XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
++ E + +Q E++I + EE +LK
Sbjct: 585 NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE-KLKVDKMAHDLEIKW-- 641
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
+ + +L +L L+ E + L Q D +N + ++K++EDL
Sbjct: 642 --TENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARD--SWQKKVEDLL 694
Query: 1453 YEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELN--- 1509
+ L +++ ++ + +Q + ER +L +EL + +K + E +
Sbjct: 695 NQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLA 754
Query: 1510 -KALEEEVAKTNEMQTALEN 1528
+ +EEE K Q ALEN
Sbjct: 755 FQTMEEEKEKE---QRALEN 771
Score = 71.7 bits (168), Expect = 2e-11
Identities = 183/931 (19%), Positives = 387/931 (41%), Gaps = 85/931 (9%)
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS 531
TE+++ K+Q L+ L D IK + + + ++ + ++ + +A + I S
Sbjct: 99 TEELDLRRKIQV-LESSLEDHIK--MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS 155
Query: 532 NHKLKLKQ-MQKTIDNFSKVSDSNKEIVRLT-EELHHLSQKVAELEEEKGNLQLHLVDYD 589
++++ ++ + +F ++ ++ RL E+L ++ E++E + Q H +
Sbjct: 156 REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRR--EIQELLKSQQDHSASVN 213
Query: 590 SGRMIESDVYKKMIEMEN--LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK---L 644
G+ ++++ +E N L E RL+ L+E + L + +++ D ++
Sbjct: 214 KGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFT 273
Query: 645 ADISQLQSDQVCSEIKSVHLEEQI--DALSASKKELALVIENLK--LDK-EQLYGTIKDL 699
A+ Q ++ K +E I + K EL +V + LDK ++L +
Sbjct: 274 AESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIA 333
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI--QTQFG-IDAK 756
EN+ + + +L + + M L K +++ +E ++ ++ + + + G + A
Sbjct: 334 ENNVQVLQKQLDDAKEGEMALLSKHKEVESE-LAAARERLQQQASDLVLKASHIGMLQAT 392
Query: 757 IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY 816
+++ I+++ESE S+ R+ +LEE A + + SL+ + Q L+ ++K
Sbjct: 393 QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQ--QILELEKKVNEAK 450
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQISLSDMQQH 875
Q++ L L QL E + +EL K+ + +E + ++ D ++
Sbjct: 451 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHS--NAIRDKKKL 508
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
L E+ N+ D E K Q Q ++LE NLK + + Q+ ++D+ +
Sbjct: 509 QMDLEEQHNK-DKLNLEEDKNQLQ-QELE-NLKEVLEDKLNTANQEIGHLQDMVRKSEQG 565
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI----DK 991
+ SA L + E+ + + L+E K+ + N+ +E+ + + E I ++
Sbjct: 566 LGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEE 625
Query: 992 HVQKQQTQSPD----YTEQYINEINKLNALLKQKDEE--------IIALNQKINN-AQVS 1038
K + D +TE E +KL L+ + EE ++ L + N A+ S
Sbjct: 626 EKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 685
Query: 1039 YMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIK 1093
+ V D ++++ LE + +Q++ Q +Q +EL+ L + + K
Sbjct: 686 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 745
Query: 1094 ELKETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
LKE L F+ + E + + + +++ E+E
Sbjct: 746 SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 805
Query: 1153 ERSVLQEQS----AKLNTELQECYTKII---------QLETLNTELTGHDVVNQEQ---- 1195
R L+++ A L +EL + I +L EL +++ Q
Sbjct: 806 LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEH 865
Query: 1196 ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK------QHLAQR 1246
I L+ +L L V L +IS+ + F+ E+ + Q +
Sbjct: 866 ICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLH 925
Query: 1247 EADFQK-TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-----VTMEQVTSLQNKLQ 1300
E D K E EL V ++A + + ++ + + T E +I V++E++ +
Sbjct: 926 EQDLNKRLEKELDV-MTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRE 984
Query: 1301 DKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
K E ++ + E A + + +I++ IED K
Sbjct: 985 SKPEDIQMITELKAMLTERDQIIKKLIEDNK 1015
>U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein.
Length = 2363
Score = 101 bits (243), Expect = 2e-20
Identities = 225/1182 (19%), Positives = 491/1182 (41%), Gaps = 87/1182 (7%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKY--EKNIEYVTQLEAQLQEYKNN 970
+ L+++ +E + + ++ SA +V+++ +NIE + Q +L
Sbjct: 501 RVLLME-LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
Query: 971 I-ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
+ E +E + + ++ T+ + +++ ++++++Q+D I L+
Sbjct: 560 LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
Q A + S + D LA + + +++S + E L
Sbjct: 620 QTTGVAIPLHASSLDDV--SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL----- 672
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD-DANNVDXXXXXXXXXXXXLKVQEE- 1147
Q++E+ E + K + + E ++D + N +Q+
Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLN 1207
E + +E + L E++ KL Q+ +II T+ +L G + E++ + + E L
Sbjct: 733 EGYRREITSLHERNQKLTATTQK-QEQII--NTMTQDLRGAN----EKLAVAEIRAENLK 785
Query: 1208 TENDNL-LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
E + L LS V + S +QRG L +L + +++E E + +LS+
Sbjct: 786 KEKEMLKLSEVRLSQQRESLLAEQRG---QNLLLTNLQTIQGILERSETETKQRLSSQIE 842
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQ---VTSLQNKLQ-DKEEHLR-NLQEKYADVINQIE 1321
K E + ++ + E + T+ + V L K Q D E +L N +E + +I
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXX-XXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
L+ + + +V D+ +Q +EQ +N+ +LK S
Sbjct: 903 TLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ----VNDLKERLKTS 958
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE-NVRQ 1439
+ V +A V L L K+ ++ ++ + + + EF+ + +
Sbjct: 959 T-----------SNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
+L+E EK ++L +K + + ++ E ++Q E + + ++ + ++
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNEQ 1062
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIE-IVTLNDEITNLQNMVRASSSKIQKHV 1558
+ E K + E E + L ++E + ++++ + ++ + QK
Sbjct: 1063 QARRDCQEQAK-IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
Query: 1559 SFASDTKQGRDEQLDNTMNKELLDAVPRAE-LDLAMYMLHQR 1599
S + K +E+ + + E+ V R E L+ +LH +
Sbjct: 1122 SQLLECKASWEER-ERMLKDEVSKCVCRCEDLEKQNRLLHDQ 1162
Score = 100 bits (240), Expect = 4e-20
Identities = 274/1525 (17%), Positives = 612/1525 (40%), Gaps = 138/1525 (9%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDL---QEKINEKDQIIEAKNK--ATTXXX 197
DV L+ +KE + LQ+K+ ++ + + + ++++ ++ +++ ++N T
Sbjct: 144 DVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT 203
Query: 198 XXXXXXXXXXXXXXE--DTKQQMTKMQENFIAMEAEW---KDEKQRLLKDIESKDVRISS 252
E + K + +E +E + K + L K +E ++
Sbjct: 204 KTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE 263
Query: 253 LEEANKLLEAARFEISLE-HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE 311
+E +E +F L H KL+ L + A + + +E E
Sbjct: 264 AKEQQASMEE-KFHNELNAHIKLSN-LYKSAADDSEAKSNELTRAVEELHKLLKEAGEAN 321
Query: 312 ---EKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSP 368
+ LE+ + +K E+LE +I + KELEN + + + S++
Sbjct: 322 KAIQDHLLEVEQSKDQMEK-EMLE----KIGRLEKELENANDLLSATKRKGAILSEEELA 376
Query: 369 LISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVI 428
+S + +K+ P +L+ E N + + ++ + KLE + +NK L + +
Sbjct: 377 AMSPTAA--AVAKIVKPGMKLT-ELYNAYVETQ-DQLLLEKLEN--KRINKYLDEIVKEV 430
Query: 429 SEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE 488
K +A L ++ +Q M+ + + +T+ N+ + V E+ +
Sbjct: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMK--EIQRLQEDTDKANKQSSVLERDNRR 488
Query: 489 LNDEIKDVN--VKDLIEKLKSAEEQITQLNDEIDAAN-KNMIKVKSNHKLKLKQMQKTID 545
+ ++KD++ ++ L+ +L+ A ++E+ +A+ + +V S H + + +++
Sbjct: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
Query: 546 NFSKVSDSNKEI--VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
++ + +E+ R EE S K+ EL+ + + L R + + ++
Sbjct: 549 QNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
Query: 604 EMEN-----LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSE 658
+ L++T AI L S D+ + + A + ++S + E
Sbjct: 609 RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI-E 667
Query: 659 IKSVHLEEQIDALSASKKELAL--VIENLKLDKEQLYGTIKDLENDKE----DIMNKLQN 712
K+ L++ + KKE A I+N +L+K Q T +N K D +K
Sbjct: 668 AKAA-LKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINHEEQ---SKIQTQFGIDAKIQERDLYIENIES 769
+Q+N++ + E+ +L A +EQ + Q G + K+ ++ EN++
Sbjct: 727 MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEIRAENLKK 786
Query: 770 ELSKYKSRICRL-EESIAVMEDRRYS-------------LERKADQLGSYLQEK-QKAYS 814
E K RL ++ +++ ++R LER + L + +K
Sbjct: 787 EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEH 846
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE----------NKEL----QKKNQILLE 860
E + + +L N + R ++ QLL+ + + KEL QK+ L
Sbjct: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKR 906
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT--QLRDLESNLKRIT---HEHQ 915
N+++ ++ + +N+ D+ + S QT Q+ DL+ LK T ++Q
Sbjct: 907 HLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQ 966
Query: 916 TLIVQKKKEI---EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN-I 971
++ ++ + + + E IE +++ + EK + V + + +LQ+ K I
Sbjct: 967 AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
Query: 972 ENLNMNVEELNKMNLELIDKHVQK--QQTQSPDYTEQYINEINKLNALLKQKDEEIIALN 1029
E++ + EL K L + VQ+ Q+ + EQ + A + + +
Sbjct: 1027 ESMEQQLSELKK-TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERE 1085
Query: 1030 QKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQD 1089
++ A V + + SK+A +++EE Q+ QLL+ K EE + +++++
Sbjct: 1086 LMLHAADVEALQAAKEQVSKMASVR---QHLEETTQKAESQLLECKASWEERERMLKDEV 1142
Query: 1090 DQI----KELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN-NVDXXXXXXXXXXXXLK- 1143
+ ++L++ I K +++S E + N ++ L+
Sbjct: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRF 1202
Query: 1144 VQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLE-TLNTELTGHDVV--NQEQINQL 1199
++ E+E + R V Q +S + ++ ++ +L+ +LN E V Q +L
Sbjct: 1203 IRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL 1262
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
K E +N + + E + + + Q ++ +L L +EA+ + +E +
Sbjct: 1263 MKKTETMNVVMETN-KMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGML 1321
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ---VTSLQNKLQDKEEHLRNLQEKYADV 1316
Q ++LL+ + +V+ ++ + L +KE H + +Q+ +
Sbjct: 1322 QAE------KKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQ----L 1371
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
+I L++EI + +RTE ++ ++ + I++I E+
Sbjct: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNK-VRTEKETIQKDLDAKIIDIQEKVKT 1430
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY---QKTHEYTITLTQRNDE 1433
+ + + + KV+E + Q E + Q+ E TL Q +
Sbjct: 1431 ITQVKKIGRRYKTQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETK 1489
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
+++ Q+ +K + EKE+E L+ +T+Q +SE+ R++ ++L
Sbjct: 1490 SKSLESQVENLQKTLS----EKETEARNLQ---------EQTVQLQSELSRLR--QDLQD 1534
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
+ T+ L +Q+ E + + + L + ++ N+E+ + +
Sbjct: 1535 RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDE 1594
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNK 1578
+ ++ +GR +L+ + +
Sbjct: 1595 LDVRITALKSQYEGRISRLERELRE 1619
Score = 95.9 bits (228), Expect = 1e-18
Identities = 178/781 (22%), Positives = 350/781 (44%), Gaps = 114/781 (14%)
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NK 555
+V DL+ +L+ EEQ+ L + + + N+ ++ + ++++++ +V++ K
Sbjct: 933 DVDDLVSQLRQTEEQVNDLKERLKTSTSNV----EQYQAMVTSLEESLNKEKQVTEEVRK 988
Query: 556 EI-VRLTEELH---HLSQKVAELEEEKGNLQLHLVDYDSGRMIES------DVYKKMIEM 605
I VRL E L +K+ E+E+EK LQ D R IES ++ K + +
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQ-----DDKRRAIESMEQQLSELKKTLSSV 1043
Query: 606 ENLAETRLK----AISLLESQKFDLVQELHIL---QQKYD-EVEDKLADISQLQS--DQV 655
+N + L+ A+S + + D ++ I Q KY+ E+ AD+ LQ+ +QV
Sbjct: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQV 1103
Query: 656 CSEIKSV--HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
S++ SV HLEE + K E L+ K E+ +KD + + + ++
Sbjct: 1104 -SKMASVRQHLEE-----TTQKAESQLL--ECKASWEERERMLKD---EVSKCVCRCEDL 1152
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK 773
++N L D++EK+S +++A + Q + + K QE+ L I +
Sbjct: 1153 EKQNRLLHDQIEKLS----DKVVASVKEGVQGPLNVSLSEEGKSQEQILEI----LRFIR 1204
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM-D 832
+ I +A +E RY ++ + L LQE Q + + E E V A M
Sbjct: 1205 REKEIAETRFEVAQVESLRY--RQRVELLERELQELQDSLNA----EREKVQVTAKTMAQ 1258
Query: 833 HDRVVEK-QLLEIEHE-NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
H+ +++K + + + E NK L+++ + L ++ Q +Q + ++ L E AN +L+E
Sbjct: 1259 HEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE-AN-AELSE 1316
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+S Q + + LE ++KR +Q L+ Q+K D E E+ +K+L+EK
Sbjct: 1317 -KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDP--DTE-EY----------RKLLSEK- 1361
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
E + + + QL ++ K I N ++ N+ ++ + + + K +T+
Sbjct: 1362 EVHTKRIQQLTEEIGRLKAEIARSNASLTN-NQNLIQSLKEDLNKVRTEK---------- 1410
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
+ K D +II + +K+ ++ + ++ T+ E ++ + +V +
Sbjct: 1411 ----ETIQKDLDAKIIDIQEKVKT--------ITQVKKIGRRYKTQYEELKAQQDKVMET 1458
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNV 1128
S ++E + V+E ++ELKET E E + + T+ +A N+
Sbjct: 1459 SAQSSGDHQEQHVSVQE----MQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNL 1514
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK-IIQLETLNTELTG 1187
L+ + +Q+R+ +EQ + TE +E K I+ ++ L G
Sbjct: 1515 QEQTVQLQSELSRLR-----QDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 1188 -HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
D + +E +LK + L+ + D L + L+S + + E+ E ++HL QR
Sbjct: 1570 VKDQLTKEN-EELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQR 1628
Query: 1247 E 1247
+
Sbjct: 1629 D 1629
Score = 92.7 bits (220), Expect = 1e-17
Identities = 169/935 (18%), Positives = 392/935 (41%), Gaps = 80/935 (8%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
T +S + +LQ ++ I L E+ N+K K +
Sbjct: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMTQDLRGA 770
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E + + K +E E +++ LL + +++ +++L+ +LE +
Sbjct: 771 NEKLAVAEIRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE 830
Query: 265 FE----ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
E +S + KL E+ L + + K +++ + +L + N
Sbjct: 831 TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL-N 889
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS--PLISR-----K 373
EL K + E + +N E++ +A+ ++ PS K L+S+ +
Sbjct: 890 TKELLKNAQK-EIATLKRHLSNMEVQ--VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 374 SGRNTASKMKSPWSQLSS---------ETLNQDTD--KKINKNEIAKLEMVIQ---SLNK 419
+ ++K+ S + E+LN++ +++ KN +L+ + L K
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 420 DLVD----KEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS--LIHVGTNTE 473
L++ K+ + +K ++ +Q E Q+ ++ S L +
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR 1066
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQ-------LNDEIDAANKNM 526
D E AK+ + + + E+ ++ D +E L++A+EQ+++ L + A +
Sbjct: 1067 DCQEQAKIAVEAQNKYERELM-LHAAD-VEALQAAKEQVSKMASVRQHLEETTQKAESQL 1124
Query: 527 IKVKSNHKLKLKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQKVAELEEE--KGNLQL 583
++ K++ + + + ++ + + D K+ L +++ LS KV +E +G L +
Sbjct: 1125 LECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
Query: 584 HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
L + + ++ + + + +AETR + ++ +ES ++ Q + +L+++ E++D
Sbjct: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFE-VAQVESLRYR--QRVELLERELQELQDS 1241
Query: 644 LADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L ++ + QV ++ + H E E ++ + + K L E L+ D +Q+ ++
Sbjct: 1242 LN--AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRK 1299
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAK 756
LE D + LQ + N +L++K + AEK + E + + Q + Q D +
Sbjct: 1300 LELD----ILPLQ---EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
Query: 757 -----IQERDLY---IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+ E++++ I+ + E+ + K+ I R S+ ++ SL+ +++ + +
Sbjct: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
QK I E V + + R + Q E++ + ++ + + ++Q +S
Sbjct: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ +MQ+ L + ++ ES+ Q L + E+ + + + QT+ +Q +
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNL--QEQTVQLQSELSRLRQ 1530
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+++ T E +R + + EK EK + + ++++ + L EEL + N
Sbjct: 1531 DLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN-GA 1587
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+D+ + + QY I++L L++ E
Sbjct: 1588 LDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Score = 66.5 bits (155), Expect = 7e-10
Identities = 138/767 (17%), Positives = 310/767 (40%), Gaps = 64/767 (8%)
Query: 98 LKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNA 157
L KE+L K+ L + S V+ DV L + +++ +
Sbjct: 888 LNTKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
Query: 158 LSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQ 217
++ L+ ++K + + Q + ++ + + + T +++
Sbjct: 948 VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKK 1007
Query: 218 MTKMQENFIAMEAEWKDEKQRLLKDIESK----DVRISSLE-EANKLLEAARFEISLEHS 272
+ ++++ + E +D+K+R ++ +E + +SS++ E + L+ A +S E
Sbjct: 1008 LMEVEKE----KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 273 --KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
+ QE + L +E K ++ + S+ ++ E T+K E
Sbjct: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR-QHLEETTQKAES 1122
Query: 331 LEHLNCQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK---MKSP 385
+ L C+ +E L+++++ + + ++ I + S + AS ++ P
Sbjct: 1123 -QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
Query: 386 WS-QLSSETLNQDTDKKI-----NKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+ LS E +Q+ +I + EIA+ + + + + E++
Sbjct: 1182 LNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDS 1241
Query: 440 XXXXGKDTLI-AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV 498
+ + A+ +H++ M+ ++V T + + + +E+L+Q+L V
Sbjct: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKM--LREEKERLEQDLQQMQAKVRK 1299
Query: 499 KDL-IEKLKSAEEQITQLNDEIDAANKNMIK-VKS----NHKLKLKQMQKTIDNFSKVSD 552
+L I L+ A ++++ + + A K + + VK N L +Q + + K+
Sbjct: 1300 LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLS 1359
Query: 553 SN----KEIVRLTEELHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM------IESDVYK 600
K I +LTEE+ L ++A N Q + + D ++ I+ D+
Sbjct: 1360 EKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDA 1419
Query: 601 KMIEMENLAET--RLKAISL--------LESQKFDLVQELHILQQKYDEVEDKLADISQL 650
K+I+++ +T ++K I L++Q+ +++ + E + ++ +L
Sbjct: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK- 709
+ +E KS LE Q++ L + E NL+ QL + L D +D +
Sbjct: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
Query: 710 --LQNYIQENMDLTDKLEKMSAEKISELLA---KINHEEQSKIQTQFGIDAKIQERDLYI 764
L+ I E + T K + KI+ L ++ E + Q +D + E D+ I
Sbjct: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
++S+ Y+ RI RLE + ++R + + + + E+Q+
Sbjct: 1600 TALKSQ---YEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 122/647 (18%), Positives = 256/647 (39%), Gaps = 39/647 (6%)
Query: 91 SESLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT 150
S L++K + +EK KQ + KR + + ++ + ++T
Sbjct: 997 SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
Query: 151 -IKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXX 209
+ + A Q + KI ++ Q K E++ ++ A +
Sbjct: 1057 ALSNEQQARRDCQEQAKIA----VEAQNKY-ERELMLHAADVEALQAAKEQVSKMASVRQ 1111
Query: 210 XXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDV-RISSLEEANKLLEAARFEIS 268
E+T Q K + + +A W +E++R+LKD SK V R LE+ N+LL ++S
Sbjct: 1112 HLEETTQ---KAESQLLECKASW-EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTEL--TK 326
+ +E Q I + EI E E+A + L +
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET-RFEVAQVESLRYRQ 1226
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
++ELLE + +EL++ L + + + + L+ + N +
Sbjct: 1227 RVELLE-------RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 387 SQLSSETLNQDTDKKINKNEIAKLEMV-IQSLNKDLVDKEYVI-SEKDTXXXXXXXXXXG 444
+ E L QD + K +L+++ +Q N +L +K ++ +EK
Sbjct: 1280 RE-EKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
Query: 445 KDTLIAQLQ---LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE----LNDEIKDVN 497
L++Q + E + + +H + EI +++ ++ + N++ +
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 498 VKDLIEKLKSAEEQITQLND----EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
+K+ + K+++ +E I + D +I K + +VK + Q ++ KV ++
Sbjct: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETR 612
+ + +E H Q++ EL+E + +S ++ + +K E NL E
Sbjct: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
++ S L + DL +Q ++ +K + + V ++ K HL D L+
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEK---EEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
+EL L K++L I L++ E +++L+ ++E+ +
Sbjct: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
>M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein.
Length = 2871
Score = 101 bits (243), Expect = 2e-20
Identities = 128/592 (21%), Positives = 274/592 (46%), Gaps = 48/592 (8%)
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN-VKDLIEKL 505
T I QL ++ ++ G + T + +++ ++LK L +++ V++ I++
Sbjct: 1375 TTIHQLTMQKEEDTSGYRA-QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 1433
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKEIVRLTEEL 564
K+ +++Q +++ + + ++++ ++ KQ ++D+ +K + D NKEI RL + +
Sbjct: 1434 KATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQ---SLDDAAKTIQDKNKEIERLKQLI 1490
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRL--KAIS---L 618
+ LE+E LQ D ++ K+ ++ + L R+ + +S
Sbjct: 1491 DKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 1550
Query: 619 LESQKFDLVQE-LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
++ Q Q L LQ + +VE++L + + S+ C K LEE+++ + S KE
Sbjct: 1551 VKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK---LEEELEGMRRSLKE 1607
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
A+ I NL EQ K E+D + L +++E ++L ++S+E + L
Sbjct: 1608 QAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSE-VEALRR 1666
Query: 738 KINHEEQSKIQTQF---GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
++ E++S Q I+++ + + E+ + +S L + ++E+ +
Sbjct: 1667 QLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRN 1726
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ----LLEIEHEN-- 848
L + D L + + +A S+ EL ++L + ++R +E Q L+ E EN
Sbjct: 1727 LRLEYDDL---RRGRSEADSDKNATILELRSQLQI--SNNRTLELQGLINDLQRERENLR 1781
Query: 849 KELQKKNQILLEENQNLQIS---LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+E++K + LE + +Q S + + Q +L+ K + ++ + + +L +S
Sbjct: 1782 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 1841
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQI---ESAIRDKKVLNEKYEKNIEYVTQLEA 962
L+ T Q L +K++ DL ++ TQ E AIR K+ +E+ EK+ E
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLN-QWKTQYSRKEEAIR--KIESER-EKS-------ER 1890
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ ++ IE L ++ + + ++ ++ Q+Q +Y EI+KL
Sbjct: 1891 EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1942
Score = 95.5 bits (227), Expect = 1e-18
Identities = 171/890 (19%), Positives = 388/890 (43%), Gaps = 97/890 (10%)
Query: 477 EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLK 536
E+ + + +L ++ N E + N K L + L+ + + +Q ++ ++ ++K +L
Sbjct: 1035 EVLEEELRLARDANSENCNKN-KFLDQNLQKYQAECSQFKAKL----ASLEELKRQAELD 1089
Query: 537 LKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
K ++ +D + ++ + N++I RLT E+ ++ +E+ DYD +
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---FDQQKNDYDQLQKA- 1145
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ---KYDEVEDKLADISQLQS 652
+ E ENL +L++ ++ +++++ + +LQ+ + E E++LA + +
Sbjct: 1146 -----RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
+++ S +++ + E +I+ + KE+++ E+D +++ N+L
Sbjct: 1201 EEM-SNLRNKY-ETEINITKTTIKEISM-----------------QKEDDSKNLRNQLDR 1241
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESE 770
+EN DL D++ +++ + + EE + Q G I K Q ++ ++ + +
Sbjct: 1242 LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQ 1301
Query: 771 LSKYKSRICR-LEESIAVMEDRRYSLER-------KADQLGSYLQEKQKAYSEYTIQEDE 822
S+ +R + LEE+ ++D+ +ER +A + Y E K + Y +
Sbjct: 1302 RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIIS 1361
Query: 823 LVNRLAVLMDHDRVVEKQL-LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L N+ ++ + QL ++ E + + + L EN++L + ++ E
Sbjct: 1362 LKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTE 1421
Query: 882 KANRT--DLAESESTKYQTQLR--DLESNLKRITHEHQTLIVQKKKEIEDL--------- 928
R D+ + ++T + R LE L+++T V+ K+ ++D
Sbjct: 1422 NLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNK 1481
Query: 929 EIEFNTQ-IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
EIE Q I+ D+K L ++ + L+ I L + +EL ++ ++
Sbjct: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID 1541
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
+ V +++T ++ N + +L L KQK EE LN+ A S+
Sbjct: 1542 Y--ERVSQERTVKDQDITRFQNSLKELQ-LQKQKVEE--ELNRLKRTA--------SEDS 1588
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIP 1107
K + +LE M ++ + ++ + Q E+ I+ + +D +++ ++ + ++
Sbjct: 1589 CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD---VLDGHLR 1645
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNT 1166
+ + T E + ++ V+ +K E Q+ ++++S LN
Sbjct: 1646 EKQ-----RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQK--AIEDKSRSLN- 1697
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL---NTEND-NLLSTVAELRS 1222
E +I +L++L LT ++ +E++ L+ + + L +E D + +T+ ELRS
Sbjct: 1698 ---ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRS 1754
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
+ + + R E+ L +RE Q+ E + L A E Q + E
Sbjct: 1755 QLQIS-NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERE 1813
Query: 1283 T--NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+ KI +EQ + +L+D+ ++ E V ++E + +I+++
Sbjct: 1814 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1863
Score = 93.5 bits (222), Expect = 6e-18
Identities = 244/1218 (20%), Positives = 510/1218 (41%), Gaps = 114/1218 (9%)
Query: 447 TLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
TL+ QL Q + + H GT +DVN ++ + + + + ++ + ++
Sbjct: 621 TLVIQLPGYPQHQTVTTTEITHHGT-CQDVNHNKVIETNRENDKQETWMLMELQKIRRQI 679
Query: 506 KSAEEQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV---RLT 561
+ E ++T N + D + + I VK N +LK +Q ++V + K+++ R +
Sbjct: 680 EHCEGRMTLKNLPLADQGSSHHITVKIN---ELKSVQNDSQAIAEVLNQLKDMLANFRGS 736
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA---ETRL--KAI 616
E+ +L +V L ++ N+ Y + + + +++ E++ E RL +
Sbjct: 737 EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796
Query: 617 SLLESQKFDLVQ-ELHILQQKYDEVEDKLADI-SQLQ-SDQVCSEIKSVHLEEQIDALSA 673
L+ K + + L ++ + + LA + ++LQ + Q+ S+ + +D
Sbjct: 797 VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY------IQENMDLTDKLEKM 727
+K L ++DK Q+ + DLE + + N NY + + D LE M
Sbjct: 857 GEKVTQLTDRWQRIDK-QIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDRKRRQDSLESM 915
Query: 728 SAEKISELLAKINHEEQ--SKIQTQFGIDAKIQE-RDLY---IENIESELSKYKSRICRL 781
+ ++ +N ++ S+I + ++Q+ +L I++ E +L+ Y S + L
Sbjct: 916 KFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975
Query: 782 E----ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR-- 835
+ + L+ AD Y++ ++ Y + L + + + + +
Sbjct: 976 LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035
Query: 836 VVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL----AES 891
V+E++L N E KN+ L + Q Q S + +L E + +L A+
Sbjct: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNT--QIESA-------IR 941
K Q+++L + R+T+E + +++K +ED + + N Q++ A +
Sbjct: 1096 NLDKCYGQIKELNEKITRLTYEIEDE-KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG 1154
Query: 942 DKKVLNEKYEKNIEY-VTQLEAQLQE-------YKNNIENL-NMNVEEL----NKMNLEL 988
+K+ +EK K EY + +L LQE Y+N + + N EE+ NK E+
Sbjct: 1155 WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 989 -IDKHVQKQ-QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
I K K+ Q D ++ N++++L+ + +EI+ LN I A +
Sbjct: 1215 NITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA 1274
Query: 1047 ESKLA---QFTTKLENMEEEMQRVSKQLL-DSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ A + K +++E E+++V +Q D+ +H + L+ + D+ KE++ K F
Sbjct: 1275 LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Query: 1103 EMNIPKTE------GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + + ++ E + N + L +Q+EE+ R+
Sbjct: 1335 QEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQ 1394
Query: 1157 ---LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE----QINQLKSKLE-QLNT 1208
L ++ L+ E++ + Q T N D+ Q+ +++Q K +LE +L
Sbjct: 1395 IDNLTRENRSLSEEIKRLKNTLTQT-TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
Query: 1209 ENDNLLSTVAELRSSISSA---VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFE 1265
+ S+ A + + EI L + L +E + +K + +L +
Sbjct: 1454 VTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL--KQLIDKETNDRKCLEDENARLQRVQ 1511
Query: 1266 SKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE----KYADVINQIE 1321
Y+ L SS E NK+ EQ + ++ R +++ ++ + + +++
Sbjct: 1512 --YD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQ 1567
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + ++E+E +L +S K+ Q I N+ + QL+++S
Sbjct: 1568 LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-QAIKITNLTQ---QLEQAS 1623
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
+ + + + E E E+ + + E Q E E+V+Q
Sbjct: 1624 IVKKRSEDDLRQQRDVLDGHLREKQRTQE----ELRRLSSEVEALRRQLLQEQESVKQAH 1679
Query: 1442 VE---YEKRIEDLTYE-KESELAILRLK-MHENANHYETMQKESEIERVKL-IEELNVKI 1495
+ ++K IED + ES++ I RL+ + EN E + E E+ ++L ++L
Sbjct: 1680 LRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTK-EHLMLEEELRNLRLEYDDLRRGR 1738
Query: 1496 TESVS-LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+E+ S N + EL L+ +T E+Q + + + E L EI Q +S++I
Sbjct: 1739 SEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRI 1798
Query: 1555 QKHVSFASDTKQGRDEQL 1572
Q+ + + Q R+ L
Sbjct: 1799 QESKNQCTQVVQERESLL 1816
>J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplakin
mRNA, 3' end. ).
Length = 1752
Score = 101 bits (243), Expect = 2e-20
Identities = 128/592 (21%), Positives = 274/592 (46%), Gaps = 48/592 (8%)
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN-VKDLIEKL 505
T I QL ++ ++ G + T + +++ ++LK L +++ V++ I++
Sbjct: 256 TTIHQLTMQKEEDTSGYRA-QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 314
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKEIVRLTEEL 564
K+ +++Q +++ + + ++++ ++ KQ ++D+ +K + D NKEI RL + +
Sbjct: 315 KATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQ---SLDDAAKTIQDKNKEIERLKQLI 371
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRL--KAIS---L 618
+ LE+E LQ D ++ K+ ++ + L R+ + +S
Sbjct: 372 DKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 431
Query: 619 LESQKFDLVQE-LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
++ Q Q L LQ + +VE++L + + S+ C K LEE+++ + S KE
Sbjct: 432 VKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK---LEEELEGMRRSLKE 488
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
A+ I NL EQ K E+D + L +++E ++L ++S+E + L
Sbjct: 489 QAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSE-VEALRR 547
Query: 738 KINHEEQSKIQTQF---GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
++ E++S Q I+++ + + E+ + +S L + ++E+ +
Sbjct: 548 QLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRN 607
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ----LLEIEHEN-- 848
L + D L + + +A S+ EL ++L + ++R +E Q L+ E EN
Sbjct: 608 LRLEYDDL---RRGRSEADSDKNATILELRSQLQI--SNNRTLELQGLINDLQRERENLR 662
Query: 849 KELQKKNQILLEENQNLQIS---LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+E++K + LE + +Q S + + Q +L+ K + ++ + + +L +S
Sbjct: 663 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 722
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQI---ESAIRDKKVLNEKYEKNIEYVTQLEA 962
L+ T Q L +K++ DL ++ TQ E AIR K+ +E+ EK+ E
Sbjct: 723 TLEAETRVKQRLECEKQQIQNDLN-QWKTQYSRKEEAIR--KIESER-EKS-------ER 771
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ ++ IE L ++ + + ++ ++ Q+Q +Y EI+KL
Sbjct: 772 EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 823
Score = 84.2 bits (199), Expect = 3e-15
Identities = 148/765 (19%), Positives = 331/765 (43%), Gaps = 82/765 (10%)
Query: 601 KMIEMENLAETRLKAISLLESQKFDLVQELHILQQ---KYDEVEDKLADISQLQSDQVCS 657
+ E ENL +L++ ++ +++++ + +LQ+ + E E++LA + ++++ S
Sbjct: 27 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEM-S 85
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
+++ + E +I+ + KE+++ E+D +++ N+L +EN
Sbjct: 86 NLRNKY-ETEINITKTTIKEISM-----------------QKEDDSKNLRNQLDRLSREN 127
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESELSKYK 775
DL D++ +++ + + EE + Q G I K Q ++ ++ + + S+
Sbjct: 128 RDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDN 187
Query: 776 SRICR-LEESIAVMEDRRYSLER-------KADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+R + LEE+ ++D+ +ER +A + Y E K + Y + L N+
Sbjct: 188 ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF 247
Query: 828 AVLMDHDRVVEKQL-LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
++ + QL ++ E + + + L EN++L + ++ E R
Sbjct: 248 ETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRV 307
Query: 887 --DLAESESTKYQTQLR--DLESNLKRITHEHQTLIVQKKKEIEDL---------EIEFN 933
D+ + ++T + R LE L+++T V+ K+ ++D EIE
Sbjct: 308 EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL 367
Query: 934 TQ-IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
Q I+ D+K L ++ + L+ I L + +EL ++ ++ +
Sbjct: 368 KQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDY--ER 425
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
V +++T ++ N + +L L KQK EE LN+ A S+ K +
Sbjct: 426 VSQERTVKDQDITRFQNSLKELQ-LQKQKVEE--ELNRLKRTA--------SEDSCKRKK 474
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+LE M ++ + ++ + Q E+ I+ + +D +++ ++ + ++ + +
Sbjct: 475 LEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD---VLDGHLREKQ-- 529
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNTELQEC 1171
T E + ++ V+ +K E Q+ ++++S LN E
Sbjct: 530 ---RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQK--AIEDKSRSLN----ES 580
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL---NTEND-NLLSTVAELRSSISSA 1227
+I +L++L LT ++ +E++ L+ + + L +E D + +T+ ELRS + +
Sbjct: 581 KIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQIS 640
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET--NK 1285
+ R E+ L +RE Q+ E + L A E Q + E+ K
Sbjct: 641 -NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 699
Query: 1286 IVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
I +EQ + +L+D+ ++ E V ++E + +I+++
Sbjct: 700 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 744
Score = 81.0 bits (191), Expect = 3e-14
Identities = 138/695 (19%), Positives = 301/695 (43%), Gaps = 93/695 (13%)
Query: 476 NEIAKVQEQLKQELNDEIKDVN--VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
N++ ++ + ++L DEI +N + E+ + AEE Q A +++ K +
Sbjct: 118 NQLDRLSRE-NRDLKDEIVRLNDSILQATEQRRRAEENALQQK----ACGSEIMQKKQHL 172
Query: 534 KLKLKQM--QKTIDNF----------SKVSDSNKEIVRLTEELHHLSQKVAELEEE---- 577
+++LKQ+ Q++ DN + D NKEI RL E +++ E E E
Sbjct: 173 EIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 232
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMI----------------EMENLAETRLKAISLLES 621
+ N ++ + E ++ K I +++NL ++
Sbjct: 233 RNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKR 292
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI-----------KSVHLEEQIDA 670
K L Q L++ ++++ + A S++ + E+ +SV ++ +D
Sbjct: 293 LKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDD 352
Query: 671 LSASKKELALVIENLK--LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS 728
+ + ++ IE LK +DKE K LE++ + + + N T+ + K+
Sbjct: 353 AAKTIQDKNKEIERLKQLIDKET--NDRKCLEDENARLQRVQYDLQKANSSATETINKLK 410
Query: 729 AEKISELLAKINHEEQSKIQTQFGIDA-----KIQERDLYIENIESELSKYKSRI----C 779
++ +I++E S+ +T D ++E L + +E EL++ K C
Sbjct: 411 VQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 470
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
+ ++ +E R SL+ +A ++ + Q+ ++A ED+L + VL H R ++
Sbjct: 471 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQR 530
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
E+ + E++ + LL+E ++++ +H+ +E +R+ L ES + +
Sbjct: 531 TQEELRRLSSEVEALRRQLLQEQESVK-QAHLRNEHFQKAIEDKSRS-LNES-----KIE 583
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN---TQIESAIRDKK--VLNEKYEKNI 954
+ L+S + +T EH L ++E+ +L +E++ A DK +L + + I
Sbjct: 584 IERLQSLTENLTKEHLML----EEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 639
Query: 955 EYVTQLEAQ--LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
LE Q + + + ENL +E+ K LE ++ +Q+ + Q ++ + +
Sbjct: 640 SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNR-IQESKNQCTQVVQERESLLV 698
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMV----------SDYESKLAQFTTKLENMEE 1062
K+ +L+Q + L ++N A+ + + ++ L Q+ T+ EE
Sbjct: 699 KIK-VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEE 757
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
++++ + S++ L+ + +IK ++E
Sbjct: 758 AIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE 792
Score = 74.9 bits (176), Expect = 2e-12
Identities = 143/716 (19%), Positives = 294/716 (41%), Gaps = 58/716 (8%)
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+S ++ Q D + K E + L QK + + ++ E +IE R + +L E+
Sbjct: 7 KSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK-EKEYEIE---RLRVLLQEE 62
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+ EY +L Y + NL E E+N + + +QK+ D ++
Sbjct: 63 GTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKE-----DDSKNLR 117
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA---QFTTKLENMEEEMQ 1065
N++++L+ + +EI+ LN I A + + A + K +++E E++
Sbjct: 118 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELK 177
Query: 1066 RVSKQLL-DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE------GMIISSTI 1118
+V +Q D+ +H + L+ + D+ KE++ K F+ + + ++
Sbjct: 178 QVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD 237
Query: 1119 EPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV---LQEQSAKLNTELQECYTKI 1175
E + N + L +Q+EE+ R+ L ++ L+ E++ +
Sbjct: 238 EEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTL 297
Query: 1176 IQLETLNTELTGHDVVNQE----QINQLKSKLE-QLNTENDNLLSTVAELRSSISSA--- 1227
Q T N D+ Q+ +++Q K +LE +L + S+ A
Sbjct: 298 TQT-TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT 356
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ + EI L + L +E + +K + +L + Y+ L SS E NK+
Sbjct: 357 IQDKNKEIERL--KQLIDKETNDRKCLEDENARLQRVQ--YD--LQKANSSATETINKLK 410
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQE----KYADVINQIEILRSEIEDEKVAFXXXXXXXXX 1343
EQ + ++ R +++ ++ + + ++++ + ++E+E
Sbjct: 411 VQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 470
Query: 1344 XXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
+L +S K+ Q I N+ + QL+++S + + + +
Sbjct: 471 KRKKLEEELEGMRRSLKE-QAIKITNLTQ---QLEQASIVKKRSEDDLRQQRDVLDGHLR 526
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVE---YEKRIEDLTYE-KESEL 1459
E E E+ + + E Q E E+V+Q + ++K IED + ES++
Sbjct: 527 EKQRTQE----ELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKI 582
Query: 1460 AILRLK-MHENANHYETMQKESEIERVKL-IEELNVKITESVS-LNKQVAELNKALEEEV 1516
I RL+ + EN E + E E+ ++L ++L +E+ S N + EL L+
Sbjct: 583 EIERLQSLTENLTK-EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISN 641
Query: 1517 AKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
+T E+Q + + + E L EI Q +S++IQ+ + + Q R+ L
Sbjct: 642 NRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLL 697
>AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein.
Length = 2871
Score = 101 bits (243), Expect = 2e-20
Identities = 128/592 (21%), Positives = 274/592 (46%), Gaps = 48/592 (8%)
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN-VKDLIEKL 505
T I QL ++ ++ G + T + +++ ++LK L +++ V++ I++
Sbjct: 1375 TTIHQLTMQKEEDTSGYRA-QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 1433
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKEIVRLTEEL 564
K+ +++Q +++ + + ++++ ++ KQ ++D+ +K + D NKEI RL + +
Sbjct: 1434 KATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQ---SLDDAAKTIQDKNKEIERLKQLI 1490
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRL--KAIS---L 618
+ LE+E LQ D ++ K+ ++ + L R+ + +S
Sbjct: 1491 DKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 1550
Query: 619 LESQKFDLVQE-LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
++ Q Q L LQ + +VE++L + + S+ C K LEE+++ + S KE
Sbjct: 1551 VKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK---LEEELEGMRRSLKE 1607
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
A+ I NL EQ K E+D + L +++E ++L ++S+E + L
Sbjct: 1608 QAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSE-VEALRR 1666
Query: 738 KINHEEQSKIQTQF---GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS 794
++ E++S Q I+++ + + E+ + +S L + ++E+ +
Sbjct: 1667 QLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRN 1726
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ----LLEIEHEN-- 848
L + D L + + +A S+ EL ++L + ++R +E Q L+ E EN
Sbjct: 1727 LRLEYDDL---RRGRSEADSDKNATILELRSQLQI--SNNRTLELQGLINDLQRERENLR 1781
Query: 849 KELQKKNQILLEENQNLQIS---LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+E++K + LE + +Q S + + Q +L+ K + ++ + + +L +S
Sbjct: 1782 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 1841
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQI---ESAIRDKKVLNEKYEKNIEYVTQLEA 962
L+ T Q L +K++ DL ++ TQ E AIR K+ +E+ EK+ E
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLN-QWKTQYSRKEEAIR--KIESER-EKS-------ER 1890
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
+ ++ IE L ++ + + ++ ++ Q+Q +Y EI+KL
Sbjct: 1891 EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1942
Score = 95.5 bits (227), Expect = 1e-18
Identities = 171/890 (19%), Positives = 388/890 (43%), Gaps = 97/890 (10%)
Query: 477 EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLK 536
E+ + + +L ++ N E + N K L + L+ + + +Q ++ ++ ++K +L
Sbjct: 1035 EVLEEELRLARDANSENCNKN-KFLDQNLQKYQAECSQFKAKL----ASLEELKRQAELD 1089
Query: 537 LKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
K ++ +D + ++ + N++I RLT E+ ++ +E+ DYD +
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---FDQQKNDYDQLQKA- 1145
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ---KYDEVEDKLADISQLQS 652
+ E ENL +L++ ++ +++++ + +LQ+ + E E++LA + +
Sbjct: 1146 -----RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
+++ S +++ + E +I+ + KE+++ E+D +++ N+L
Sbjct: 1201 EEM-SNLRNKY-ETEINITKTTIKEISM-----------------QKEDDSKNLRNQLDR 1241
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG--IDAKIQERDLYIENIESE 770
+EN DL D++ +++ + + EE + Q G I K Q ++ ++ + +
Sbjct: 1242 LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQ 1301
Query: 771 LSKYKSRICR-LEESIAVMEDRRYSLER-------KADQLGSYLQEKQKAYSEYTIQEDE 822
S+ +R + LEE+ ++D+ +ER +A + Y E K + Y +
Sbjct: 1302 RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIIS 1361
Query: 823 LVNRLAVLMDHDRVVEKQL-LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
L N+ ++ + QL ++ E + + + L EN++L + ++ E
Sbjct: 1362 LKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTE 1421
Query: 882 KANRT--DLAESESTKYQTQLR--DLESNLKRITHEHQTLIVQKKKEIEDL--------- 928
R D+ + ++T + R LE L+++T V+ K+ ++D
Sbjct: 1422 NLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNK 1481
Query: 929 EIEFNTQ-IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
EIE Q I+ D+K L ++ + L+ I L + +EL ++ ++
Sbjct: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID 1541
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
+ V +++T ++ N + +L L KQK EE LN+ A S+
Sbjct: 1542 Y--ERVSQERTVKDQDITRFQNSLKELQ-LQKQKVEE--ELNRLKRTA--------SEDS 1588
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIP 1107
K + +LE M ++ + ++ + Q E+ I+ + +D +++ ++ + ++
Sbjct: 1589 CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD---VLDGHLR 1645
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLNT 1166
+ + T E + ++ V+ +K E Q+ ++++S LN
Sbjct: 1646 EKQ-----RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQK--AIEDKSRSLN- 1697
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL---NTEND-NLLSTVAELRS 1222
E +I +L++L LT ++ +E++ L+ + + L +E D + +T+ ELRS
Sbjct: 1698 ---ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRS 1754
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
+ + + R E+ L +RE Q+ E + L A E Q + E
Sbjct: 1755 QLQIS-NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERE 1813
Query: 1283 T--NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+ KI +EQ + +L+D+ ++ E V ++E + +I+++
Sbjct: 1814 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1863
Score = 92.7 bits (220), Expect = 1e-17
Identities = 244/1218 (20%), Positives = 510/1218 (41%), Gaps = 114/1218 (9%)
Query: 447 TLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL 505
TL+ QL Q + + H GT +DVN ++ + + + + ++ + ++
Sbjct: 621 TLVIQLPGYPQHQTVTTTEITHHGT-CQDVNHNKVIETNRENDKQETWMLMELQKIRRQI 679
Query: 506 KSAEEQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV---RLT 561
+ E ++T N + D + + I VK N +LK +Q ++V + K+++ R +
Sbjct: 680 EHCEGRMTLKNLPLADQGSSHHITVKIN---ELKSVQNDSQAIAEVLNQLKDMLANFRGS 736
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA---ETRL--KAI 616
E+ +L +V L ++ N+ Y + + + +++ E++ E RL +
Sbjct: 737 EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796
Query: 617 SLLESQKFDLVQ-ELHILQQKYDEVEDKLADI-SQLQ-SDQVCSEIKSVHLEEQIDALSA 673
L+ K + + L ++ + + LA + ++LQ + Q+ S+ + +D
Sbjct: 797 VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY------IQENMDLTDKLEKM 727
+K L ++DK Q+ + DLE + + N NY + + D LE M
Sbjct: 857 GEKVTQLTDRWQRIDK-QIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESM 915
Query: 728 SAEKISELLAKINHEEQ--SKIQTQFGIDAKIQE-RDLY---IENIESELSKYKSRICRL 781
+ ++ +N ++ S+I + ++Q+ +L I++ E +L+ Y S + L
Sbjct: 916 KFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975
Query: 782 E----ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR-- 835
+ + L+ AD Y++ ++ Y + L + + + + +
Sbjct: 976 LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035
Query: 836 VVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL----AES 891
V+E++L N E KN+ L + Q Q S + +L E + +L A+
Sbjct: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED-LEIEFNT--QIESA-------IR 941
K Q+++L + R+T+E + +++K +ED + + N Q++ A +
Sbjct: 1096 NLDKCYGQIKELNEKITRLTYEIEDE-KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG 1154
Query: 942 DKKVLNEKYEKNIEY-VTQLEAQLQE-------YKNNIENL-NMNVEEL----NKMNLEL 988
+K+ +EK K EY + +L LQE Y+N + + N EE+ NK E+
Sbjct: 1155 WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 989 -IDKHVQKQ-QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
I K K+ Q D ++ N++++L+ + +EI+ LN I A +
Sbjct: 1215 NITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA 1274
Query: 1047 ESKLA---QFTTKLENMEEEMQRVSKQLL-DSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ A + K +++E E+++V +Q D+ +H + L+ + D+ KE++ K F
Sbjct: 1275 LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Query: 1103 EMNIPKTE------GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + + ++ E + N + L +Q+EE+ R+
Sbjct: 1335 QEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQ 1394
Query: 1157 ---LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE----QINQLKSKLE-QLNT 1208
L ++ L+ E++ + Q T N D+ Q+ +++Q K +LE +L
Sbjct: 1395 IDNLTRENRSLSEEIKRLKNTLTQT-TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
Query: 1209 ENDNLLSTVAELRSSISSA---VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFE 1265
+ S+ A + + EI L + L +E + +K + +L +
Sbjct: 1454 VTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL--KQLIDKETNDRKCLEDENARLQRVQ 1511
Query: 1266 SKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE----KYADVINQIE 1321
Y+ L SS E NK+ EQ + ++ R +++ ++ + + +++
Sbjct: 1512 --YD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQ 1567
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + ++E+E +L +S K+ Q I N+ + QL+++S
Sbjct: 1568 LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-QAIKITNLTQ---QLEQAS 1623
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
+ + + + E E E+ + + E Q E E+V+Q
Sbjct: 1624 IVKKRSEDDLRQQRDVLDGHLREKQRTQE----ELRRLSSEVEALRRQLLQEQESVKQAH 1679
Query: 1442 VE---YEKRIEDLTYE-KESELAILRLK-MHENANHYETMQKESEIERVKL-IEELNVKI 1495
+ ++K IED + ES++ I RL+ + EN E + E E+ ++L ++L
Sbjct: 1680 LRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTK-EHLMLEEELRNLRLEYDDLRRGR 1738
Query: 1496 TESVS-LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+E+ S N + EL L+ +T E+Q + + + E L EI Q +S++I
Sbjct: 1739 SEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRI 1798
Query: 1555 QKHVSFASDTKQGRDEQL 1572
Q+ + + Q R+ L
Sbjct: 1799 QESKNQCTQVVQERESLL 1816
>BC090932-1|AAH90932.1| 1377|Homo sapiens NIN protein protein.
Length = 1377
Score = 101 bits (242), Expect = 2e-20
Identities = 183/925 (19%), Positives = 381/925 (41%), Gaps = 71/925 (7%)
Query: 663 HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD----LENDKEDIMNKLQNYIQENM 718
HL E++D + K++L ++ + K + + D +E E + KL +E +
Sbjct: 371 HLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERI 430
Query: 719 DLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
+ E+I + K E + +I+ + I++R + E S+ ++ +
Sbjct: 431 AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR---LALSLKENSRLENEL 487
Query: 779 CRLEESIAVMEDRRYSLERKADQ-LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
E +A E+ L+R + L + + +E+ +QE+ L RV+
Sbjct: 488 LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL 547
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
+ Q+ E++ E +E + + ++L +N S S+ + + +E + L E
Sbjct: 548 QDQVDELQSELEEYRAQGRVLRLPLKN---SPSEEVEANSGGIEPEH--GLGSEECNPLN 602
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + E ++++ +H I + E+ED + Q++ + K E ++ E
Sbjct: 603 MSI-EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE 661
Query: 958 TQ-LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
T LE Q+ + KN I L L + + E +H ++++ E+ + KL
Sbjct: 662 THTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRL 721
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-- 1074
Q + E+ A ++ AQ S+ +S A K+ + +E+++ ++ L S
Sbjct: 722 ---QHEMELKA---RLTQAQASFEREREGLQSS-AWTEEKVRGLTQELEQFHQEQLTSLV 774
Query: 1075 KQHNEELQILVREQ-DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
++H E + L +E + +EL+E + +E + E I+ + I ++++ +++
Sbjct: 775 EKHTLEKEELRKELLEKHQRELQEGR--YESEKLQQENSILRNEITTLNEE-DSISNLKL 831
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
Q+ E QE + +Q+ L ++ E K QL+ NTEL+ + NQ
Sbjct: 832 GTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 891
Query: 1194 EQINQL----------------KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
E++ +L S LE+ E NL + + S+ V E++E
Sbjct: 892 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 951
Query: 1238 LWKQ-HLAQREADFQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE-ETNKIVTMEQVT 1293
+ Q H+ Q+E K E E QL S ++Q + SV S ++ K E++
Sbjct: 952 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1011
Query: 1294 SLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEI--EDEKVA-FXXXXXXXXXXXXX 1347
S +KL E + ++++ +Q L+S++ EKV
Sbjct: 1012 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1071
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
DLR Q K+ +Q +++++++ S +L H
Sbjct: 1072 MKSDLRVTQQE-KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH 1130
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
+ + ++Q+ +E T+ Q N + +L +++ L ES L L H
Sbjct: 1131 LMNEEQQLLWQE-NERLQTMVQ------NTKAELTHSREKVRQL----ESNL----LPKH 1175
Query: 1468 ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
+ + +E E++ L E + E N++V+++N +LE+E+ + L+
Sbjct: 1176 QKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQELETIHLENEGLK 1234
Query: 1528 NQEIEIVTLNDEITNLQNMVRASSS 1552
+++++ E+ +L++ S S
Sbjct: 1235 KKQVKLDEQLMEMQHLRSTATPSPS 1259
Score = 87.0 bits (206), Expect = 5e-16
Identities = 136/671 (20%), Positives = 303/671 (45%), Gaps = 50/671 (7%)
Query: 458 QHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK--LKSA---EEQI 512
+H E + V E + K++ Q + EL + E+ L+S+ EE++
Sbjct: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
Query: 513 TQLNDEIDAANKNMI-KVKSNHKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHHLSQ 569
L E++ ++ + + H L+ ++++K + + ++ + E +L +E L
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQENSILRN 815
Query: 570 KVAELEEEKG--NLQLHLVDYDSGRMIESD--VYKKMIEMENLAETRLKAISLLESQKFD 625
++ L EE NL+L ++ M + V ++ ++ + E K IS L+ +
Sbjct: 816 EITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQ 875
Query: 626 LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENL 685
L E L QK + ++KL +++Q ++ +C + K E AL ++E + E L
Sbjct: 876 LDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK----EPGNSALEEREQEKFNLKEEL 931
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYI--QENMDLTDKLEKMSAEKISELLAKINHEE 743
+ K Q + LE + ++ K+Q +I QEN L D+LEKM L+
Sbjct: 932 ERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDELEKMKQLHRCPDLSDF---- 985
Query: 744 QSKIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
Q KI + + K+ +E++ E + S + K ++ LE IA M+ + S E ++ L
Sbjct: 986 QQKISSVLSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASL 1044
Query: 803 GSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
S L Q+ E T+Q L +++ + RV +++ ++ E L K+ Q
Sbjct: 1045 KSQLVASQEKVQNLEDTVQNVNL--QMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG 1102
Query: 861 ENQNLQIS-----LSDMQQH--YNALVEKANRTD-LAESESTKYQTQLRDLESNL----K 908
++ +I+ L + Q+ ++ L N L E+ + QT +++ ++ L +
Sbjct: 1103 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1162
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
++ L+ + +K + T+ E ++ ++++K + +Q+ +
Sbjct: 1163 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC--DQFQKEQSPANRKVSQMNSLE 1220
Query: 969 NNIENLNMNVEELNKMNLELIDK-----HVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
+E +++ E L K ++L ++ H++ T SP + ++ + A E
Sbjct: 1221 QELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS-PHAWDLQLLQQQACPMVPRE 1279
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
+ + L +++ A+ + + E++ ++ T N E+ + + +++++ +Q + ++
Sbjct: 1280 QFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR 1339
Query: 1084 LVREQDDQIKE 1094
L++E+ +Q+KE
Sbjct: 1340 LLQEKVNQLKE 1350
Score = 72.9 bits (171), Expect = 9e-12
Identities = 161/886 (18%), Positives = 384/886 (43%), Gaps = 68/886 (7%)
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
H + + K+ E+ K+ + +K+ K+ + L+ A +Q +L EI+ A
Sbjct: 408 HAAIERRNEYNLRKLDEEYKERIA-ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEE 466
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH-----LSQKVAELE------ 575
++ L LK+ + + + ++ E LT +L L++K +L+
Sbjct: 467 NYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 526
Query: 576 --EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL-AETRLKAISLLESQKFDLVQELHI 632
+E+ Q+ R+++ V + E+E A+ R+ + L S ++
Sbjct: 527 FLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGG 586
Query: 633 LQQKYDEVEDKLADIS-QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
++ ++ ++ ++ ++++ V ++K H I L ++ E +LD E
Sbjct: 587 IEPEHGLGSEECNPLNMSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEK-QLD-ET 643
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ- 750
+ K EN K+ N+ ++ DL +++ ++ + + +L + +HE + + +
Sbjct: 644 VVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQ--AAVLKEAHHEATCRHEEEK 701
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQ 810
+ K++E +++ + L RL ++ A E R L+ A + +EK
Sbjct: 702 KQLQVKLEEEKTHLQE-KLRLQHEMELKARLTQAQASFEREREGLQSSA-----WTEEKV 755
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE----ENQNLQ 866
+ + QE E ++ + +VEK LE E KEL +K+Q L+ E++ LQ
Sbjct: 756 RGLT----QELEQFHQEQL----TSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQ 807
Query: 867 ISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE 926
S ++ L E+ + ++L Q ++ +K+ Q ++ KK+I
Sbjct: 808 QENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQIS 867
Query: 927 DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKMN 985
+L+I+ N Q++ + N + ++ ++ + Q L L + + N + E K N
Sbjct: 868 ELKIK-NQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFN 926
Query: 986 LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD 1045
L+ + + Q + E ++E+ K+ + Q++ ++ ++ Q+ +SD
Sbjct: 927 LKEELERCKVQSSTLVSSLEAELSEV-KIQTHIVQQENHLLK-DELEKMKQLHRCPDLSD 984
Query: 1046 YESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN 1105
++ K++ + E + +E + +S++L + +L + +I +K+ + ++E
Sbjct: 985 FQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLL----EHRIATMKQEQKSWEHQ 1040
Query: 1106 IPKTEGMIISS--TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK 1163
+ +++S ++ + D NV+ L+V + QE+ L+++
Sbjct: 1041 SASLKSQLVASQEKVQNLEDTVQNVN---LQMSRMKSDLRVTQ-----QEKEALKQEVMS 1092
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDV---VNQEQINQLKSKLEQLN-TENDNLLSTVAE 1219
L+ +LQ K E H+ ++ ++++ L ++ +QL EN+ L + V
Sbjct: 1093 LHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQN 1152
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSST 1279
++ ++ + ++ + L +H Q+ + T + + + + + +Q QS
Sbjct: 1153 TKAELTHSREKVRQLESNLLPKH--QKHLNPSGTMNPTEQEKLSLKRECDQ-FQKEQSPA 1209
Query: 1280 QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
+ +++ ++EQ L+ + + E L+ Q K + + +++ LRS
Sbjct: 1210 NRKVSQMNSLEQ--ELET-IHLENEGLKKKQVKLDEQLMEMQHLRS 1252
Score = 42.3 bits (95), Expect = 0.014
Identities = 70/398 (17%), Positives = 154/398 (38%), Gaps = 26/398 (6%)
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N L + ++Q + K+++ L D ++ +LRS + A + +E+
Sbjct: 348 NELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDH 407
Query: 1242 HLA---QREADFQKTEHELRVQLSAFESKY----EQLLDSV---QSSTQEETNKIVTMEQ 1291
H A + E + +K + E + +++A +++ EQ+L + ++E K T E
Sbjct: 408 HAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEEN 467
Query: 1292 ------VTSLQNKLQDKEEHLRNLQE--KYADVINQIEILRSEIEDEKVAFXXXXXXXXX 1343
SL+ + + E L N ++ +Y ++ N+++ + EK
Sbjct: 468 YIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 527
Query: 1344 XXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
+R E + ++ + + + E + + +A + +
Sbjct: 528 LQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI 587
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDE-FENVRQQLVEYEKRIEDLTYEKESELAIL 1462
E H L ++ + E + + Q ++ ++ +E E ++ YEK+ + ++
Sbjct: 588 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH--YEKQLDETVV 645
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
K + E M++ E E L ++++ E L Q A L +A E + E
Sbjct: 646 SCKKAQ-----ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 700
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSF 1560
+ L+ + E T E LQ+ + + Q SF
Sbjct: 701 KKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 738
>AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein.
Length = 1540
Score = 101 bits (242), Expect = 2e-20
Identities = 225/1122 (20%), Positives = 487/1122 (43%), Gaps = 117/1122 (10%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
TN++ V+ K+ +ELN+ + + + + E L+++ +Q+ + N E++ + K+
Sbjct: 109 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKI 168
Query: 530 KSNHKLKLKQM--QKTIDNFSK-VSDSNKE-IVRLTEELHHLSQKVAELEE--------- 576
+ + K++QM + D+ SK VSD++++ I+ L + L +V++L E
Sbjct: 169 NLDAQ-KVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQV 227
Query: 577 ------------EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES--Q 622
E +L++ L+DY + +S + K +L + A+ LES
Sbjct: 228 EILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITS 287
Query: 623 KFDLVQELHI-LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
K ++ ++ L+QK DE E L ++L+ ++ HL + I +L +
Sbjct: 288 KLQKMEAYNLRLEQKLDEKEQALY-YARLEGRN-----RAKHLRQTIQSLRRQFSGALPL 341
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK-LE-KMSAEKISELLAKI 739
+ K K T+ L+NDK IM +++N QE+ ++ +K LE ++ + + EL++ +
Sbjct: 342 AQQEKFSK-----TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTL 396
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
++ Q KI+E L + EL K K I L I+ E SLE +
Sbjct: 397 --KDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEI 454
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
Q + +E+Q A+ + +E +L +L + + + E + + L
Sbjct: 455 VQQNKFHEERQMAWDQ---REVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPL- 510
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL---KRITHEHQT 916
NQ L+I+L ++++ ++E E + + ++ LR E N+ ++ +E +
Sbjct: 511 -PNQ-LEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELR- 567
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
L + E E L E + E + L ++ + ++A+L + + ++
Sbjct: 568 LRLPATAEREKLIAELGRK-EMEPKSHHTLKIAHQT----IANMQARLNQKEEVLKKYQR 622
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA----LLKQKDEEIIALNQKI 1032
+E+ + E++ KH + Q + +NK L+KQ + I
Sbjct: 623 LLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFI 682
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK-QHNEELQILVRE-QDD 1090
A++ V++ + L+ KL+ + ++++R +++ + K + E +++ ++E +D
Sbjct: 683 RLAEME--QTVAEQDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKLQLQENHED 739
Query: 1091 QIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX--XXXXXXXXXLKVQE 1146
++K++K L + ++ + E + S ++ + + L ++E
Sbjct: 740 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 799
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+++ R++L E A++ +E +II + + +LK+++E L
Sbjct: 800 KQQKALSRALL-ELRAEMTAAAEE---RIISATSQKEAHLNVQQIVDRHTRELKTQVEDL 855
Query: 1207 NTEN----DNLLSTVAELRSSISSAVDQRGFEIAELWKQH--LAQREADFQKTEHELRVQ 1260
N EN L T +S++ ++ E+ + K + + + + + + EL+ Q
Sbjct: 856 N-ENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQ 914
Query: 1261 LSAFES--KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
+ S + + L D+ QS +E K+ +E L+ K++ E L+ ++EK A
Sbjct: 915 IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE--NQLEGKVE--EVDLKPMKEKNA---- 966
Query: 1319 QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLK 1378
+ E++R E E +K + ++ T + +++ E+ +
Sbjct: 967 KEELIRWE-EGKK--WQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQR 1023
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLEL-THQLELKDSEIYQKTHEYTITLTQRND-EFEN 1436
K R ++E ++ EL L+L++ +Y + H+ + D +N
Sbjct: 1024 KLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQN 1083
Query: 1437 --VRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVK 1494
++++L EK+ TY K S I E+ +H Q+E E+++ E L +
Sbjct: 1084 RYLQEKLHALEKQFSKDTYSKPSISGI------ESDDH---CQREQELQK----ENLKLS 1130
Query: 1495 ITESVSLNKQVAELNK---ALEEEVAKTNEMQTALENQEIEI 1533
+E++ L Q+ + NK L+ +V EM L+ ++ E+
Sbjct: 1131 -SENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEV 1171
Score = 101 bits (241), Expect = 3e-20
Identities = 297/1482 (20%), Positives = 608/1482 (41%), Gaps = 157/1482 (10%)
Query: 140 QLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIE-AKNKATTXXXX 198
Q ++T I +KDN L ++ +E + L+E++ ++ +E K K T
Sbjct: 29 QYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQA 88
Query: 199 XXXXXXXXXXXXXEDTKQQMTK-----MQENFIAMEAEWKDEKQRL---LKDIESKDVRI 250
+ K+ +T + + +E + +E+QR K E +
Sbjct: 89 WEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSL 148
Query: 251 SSLEEANKLLE---AARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK 307
+EE N LE A +I+L+ K+ Q L +Q I EK
Sbjct: 149 KQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD--RQRILEL--EK 204
Query: 308 TEIEEKGSLEIANMTELTKKIEL-LEHLNCQIRQTNKELEN---KLATMGTESKAVSSPS 363
E+E K +E++ + E++ +E LN Q + +KE+E+ +L +S S +
Sbjct: 205 NEMELK--VEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIA 262
Query: 364 KKGSPLISRKSGRNTA-SKMKSPWSQLSS-ETLNQDTDKKINKNEIAKLEMVIQSLNKDL 421
K +S + TA K++S S+L E N ++K+++ E A ++ N+
Sbjct: 263 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 322
Query: 422 VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
++ + S + L L Q+ ++I + + + + K
Sbjct: 323 HLRQTIQSLRRQFSGA--------------LPLAQQEKFS-KTMIQLQNDKLKIMQEMKN 367
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
+Q + + ++ ++ +K LK EE I+ L D K KV + H +K+++++
Sbjct: 368 SQQEHRNMENKTLEMELK-----LKGLEELISTLKD-----TKGAQKVINWH-MKIEELR 416
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY-K 600
+ N+E+V+ EE+ +L+ ++E E +L+ +V + + +
Sbjct: 417 L------QELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ 470
Query: 601 KMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
+ +++E + + + + Q+ +++ QK++E + D S +Q+ EI
Sbjct: 471 REVDLE-------RQLDIFDRQQNEILNAA----QKFEEATGSIPDPSLPLPNQL--EIA 517
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ---EN 717
++E I + ++ + E LK +KE + ++ ++N+L+ + E
Sbjct: 518 LRKIKENIRIILETRATCKSLEEKLK-EKESALRLAEQNILSRDKVINELRLRLPATAER 576
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
L +L + E S KI H+ + +Q + ++ ++ Y +E + +
Sbjct: 577 EKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKK--YQRLLEKAREEQREI 634
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY-----SEYTIQEDELVNRLA---- 828
+ + EE + ++ R LE +AD S + KQ A+ S + ++ RLA
Sbjct: 635 VKKHEEDLHILHHR---LELQADS--SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 689
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQIL---LEENQNLQISLSDMQQHYNALVEKANR 885
+ + D + L++++ +++L+++ +I ++E +N+++ L Q+++ V+K
Sbjct: 690 TVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQL---QENHEDEVKKVK- 745
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
AE E KY ES + L QK+ +E ++ +
Sbjct: 746 ---AEVEDLKYLLDQSQKESQCLK-----SELQAQKEANSRAPTTTMRNLVER-LKSQLA 796
Query: 946 LNEKYEKNIEY-VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
L EK +K + + +L A++ + +E + +++D+H ++ +TQ D
Sbjct: 797 LKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLN 856
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
E + KL LK +L +N+ Y +K+ + +++ +E+
Sbjct: 857 ENLL----KLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY-NKILREKEEIDQENDEL 911
Query: 1065 QRVSKQL---LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
+R K+L L K + Q L+ E ++K+L+ + EG + ++PM
Sbjct: 912 KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLEN----------QLEGKVEEVDLKPM 961
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS-VLQEQSAKLNTELQECYTKIIQLE- 1179
+ N + K++ ++E+ + + +LNT L++ + K + +
Sbjct: 962 KEK-NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT-LKDLFAKADKEKL 1019
Query: 1180 TLNTEL--TGHDVVNQEQINQLKSK--LEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
TL +L TG V I L+S+ LE+L N +L + + +R+ + D E
Sbjct: 1020 TLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VED 1078
Query: 1236 AELWKQHLAQR----EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ 1291
L ++L ++ E F K + + +S ES D Q + + + +
Sbjct: 1079 LHLQNRYLQEKLHALEKQFSKDTYS-KPSISGIESD-----DHCQREQELQKENLKLSSE 1132
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
L+ +L+ + L L+ + D+ E L+ E +V +
Sbjct: 1133 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKE--KAEVQRKLGHVRGSGRSGKTIPE 1190
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA-EAKVLELTHQLE 1410
L K++ E+ + EN QLKK+S + N+ +A++ +L L
Sbjct: 1191 LEKTIGLMKKVVEK----VQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG 1246
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ S Y+ + T + N E +R++L + E L K + L IL KM
Sbjct: 1247 HQLSMHYESKTKGTEKIIAEN---ERLRKELKKETDAAEKLRIAKNN-LEILNEKMTVQL 1302
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
+ +E R +E + K +S+ + + K LE ++AK N+ T L+ Q
Sbjct: 1303 EETGKRLQFAE-SRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLK-QL 1360
Query: 1531 IEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
++ T ++ N N KI KHV ++T+QG +L
Sbjct: 1361 VKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKREL 1402
Score = 95.1 bits (226), Expect = 2e-18
Identities = 183/944 (19%), Positives = 398/944 (42%), Gaps = 63/944 (6%)
Query: 165 MKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQEN 224
+KI TI ++Q ++N+K+++++ + ++ ++
Sbjct: 596 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADS 655
Query: 225 FIAM--EAEWKDEKQRLLKDIESKD-VRISSLEEANKLLEAARFEISLEHSKLAQELEQX 281
+ + W KQ +K +R++ +E+ + + + ++ K++Q+LE+
Sbjct: 656 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ 715
Query: 282 XXXXXXXXXXXXXLAKQSIEPSCEE----KTEIEE-KGSLEIANMTELTKKIELLEHLNC 336
+ Q E +E K E+E+ K L+ + K EL
Sbjct: 716 REITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEA 775
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
R + N + + ++ K S + TA+ + S S + +
Sbjct: 776 NSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL 835
Query: 397 DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
+ + ++++ +L+ ++ LN++L+ + + + + + Q +
Sbjct: 836 NVQQIVDRHT-RELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY 894
Query: 457 QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
+ + I N E +I ++ L+ + + K +++L K+K E Q+
Sbjct: 895 NKILREKEEIDQ-ENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV 953
Query: 517 DEIDAANKNMIKVKSNHKL----KLKQMQKTIDNF-SKVSDSNKEIVRLTEELHHLSQKV 571
+E+D K M + + +L + K+ Q I+ +K+ + E+ LT++L+ L
Sbjct: 954 EEVDL--KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLF 1011
Query: 572 AELEEEKGNLQLHL------VDYDSG-RMIESDVYKKMIEMENL-AETRLKAISLLESQK 623
A+ ++EK LQ L VD G R +ES+ + ++ NL E + + ++
Sbjct: 1012 AKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALP 1071
Query: 624 FD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
D +V++LH LQ +Y +++KL + + S S+ +E ++E L
Sbjct: 1072 RDSVVEDLH-LQNRY--LQEKLHALEKQFSKDTYSKPSISGIESD----DHCQREQELQK 1124
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
ENLKL E + + LE +D+ +L+N +++ ++ + L+K AE + L +
Sbjct: 1125 ENLKLSSENIELKFQ-LEQANKDLP-RLKNQVRDLKEMCEFLKKEKAE-VQRKLGHVRGS 1181
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSLERKADQ 801
+S +T ++ I +E ++ E + K L E +A +E L+ + ++
Sbjct: 1182 GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEK 1240
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L ++L + + E + E ++ +++R+ ++ E + K KN + +
Sbjct: 1241 LKAHLGHQLSMHYESKTKGTE-----KIIAENERLRKELKKETDAAEKLRIAKNNLEIL- 1294
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK 921
N+ + + L + + + + + A+S+S K R E+ LK + +T I +K
Sbjct: 1295 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKEL----ETDIAKK 1350
Query: 922 KKEIEDLE--IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
+ I DL+ ++ T+ E + E+ K +++V + Q K ++ L +
Sbjct: 1351 NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANH 1410
Query: 980 ELNKMNLELIDK-HVQKQQTQS----PDYTEQYINEINKLNALLKQKD-------EEIIA 1027
+L+K ELI + K Q+ + PD +Q +I L LK D EEI
Sbjct: 1411 QLDKEKAELIHQIEANKDQSGAESTIPD-ADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 1469
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
L +++ N S+ + D + + K +EE+++++S+QL
Sbjct: 1470 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 1513
Score = 83.4 bits (197), Expect = 6e-15
Identities = 203/982 (20%), Positives = 401/982 (40%), Gaps = 87/982 (8%)
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
+ EL + ++Y+E+ K DI Q + V HLE + +L K+++ + + L+
Sbjct: 20 LSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISL---KEQVESINKELE 76
Query: 687 LDKEQLYGTIKDLEND----KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
+ KE+L+ + E + E M+K + I N D+ +K++ ++ EL + E
Sbjct: 77 ITKEKLHTIEQAWEQETKLGNESSMDKAKKSI-TNSDIVSISKKITMLEMKELNERQRAE 135
Query: 743 EQSKIQTQFGIDAK-IQERDLYIENIESELSKYKSRICRLEE----------SIAVME-D 790
K+ K ++ER+ +E +EL+K ++E+ S AV + D
Sbjct: 136 HCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD 195
Query: 791 RRYSLERKADQLGSYLQ-EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
R+ LE + +++ ++ K + S+ ++ E++N A D+ VE +++
Sbjct: 196 RQRILELEKNEMELKVEVSKLREISDIARRQVEILN--AQQQSRDKEVESLRMQLLDYQA 253
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+ +K+ I N+ + LS+ L ++ E+ + + + +L + E L
Sbjct: 254 QSDEKSLIAKLHQHNVSLQLSEATA-LGKLESITSKLQKMEAYNLRLEQKLDEKEQALYY 312
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK--KVLNEKYEKNIEYVTQLEAQLQEY 967
E + ++ I+ L +F+ + A ++K K + + ++ + +++ QE+
Sbjct: 313 ARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEH 372
Query: 968 KNNIENLNMNVEELNKMNLELID-----KHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
+ N+EN + +E K ELI K QK E + E+ KLN L +
Sbjct: 373 R-NMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL-KLNRELVKDK 430
Query: 1023 EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
EEI + +NN Y +S E ++ Q K EE ++ +D ++ +L
Sbjct: 431 EEI----KYLNNIISEYERTISSLEEEIVQ-QNKFH--EERQMAWDQREVDLER---QLD 480
Query: 1083 ILVREQDDQIKELKE----TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
I R+Q++ + ++ T + ++P + I+ + + ++ +
Sbjct: 481 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA--LRKIKENIRIILETRATCKSL 538
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
LK +E + E+++L K+ EL+ + E L EL G + + +
Sbjct: 539 EEKLKEKESALRLAEQNILSRD--KVINELRLRLPATAEREKLIAEL-GRKEMEPKSHHT 595
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR 1258
LK Q L+ E+ +++ E E+ K+H E D H L
Sbjct: 596 LKI-AHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKH----EEDLHILHHRLE 650
Query: 1259 VQLSAFESKYEQLLDSV--QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+Q + +K++Q + QS T TNK ++ ++ + ++++ L +L K V
Sbjct: 651 LQADSSLNKFKQTAWDLMKQSPTPVPTNK--HFIRLAEMEQTVAEQDDSLSSLLVKLKKV 708
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
+E R E + F ++ E + K + +QS +E+
Sbjct: 709 SQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQS----QKESQC 764
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
LK S V L QL LK+ + QK + E
Sbjct: 765 LK--SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQ--QKALSRAL--------LEL 812
Query: 1437 VRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKIT 1496
+ E+RI T +KE+ L + ++ + + +T ++ +KL E L
Sbjct: 813 RAEMTAAAEERIISATSQKEAHLNVQQI-VDRHTRELKTQVEDLNENLLKLKEALKTSKN 871
Query: 1497 ESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
SL + +LN L+++ N++ L +E EI NDE L+ ++ +S +Q
Sbjct: 872 RENSLTDNLNDLNNELQKKQKAYNKI---LREKE-EIDQENDE---LKRQIKRLTSGLQG 924
Query: 1557 HVSFASDTKQGRDEQLDNTMNK 1578
+D KQ E+L + K
Sbjct: 925 KP--LTDNKQSLIEELQRKVKK 944
Score = 60.5 bits (140), Expect = 5e-08
Identities = 172/889 (19%), Positives = 367/889 (41%), Gaps = 82/889 (9%)
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
EL K +E +K + D + +R +E++E E K ++ + + + + +++ +
Sbjct: 24 ELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLH 83
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVN--RLAVLMDHDRVVEKQLLE-IEHENKE 850
++E+ +Q E ++ +I ++V+ + +++ + E+Q E + +
Sbjct: 84 TIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEH 143
Query: 851 LQKKNQILLEENQNLQISLSDMQQ-HYNAL-VEKANRTDLAESESTKYQTQLRDLESNLK 908
L+ + + E N L+ +++ + + +A VE+ R +LA+S S R L+
Sbjct: 144 LRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE 203
Query: 909 RITHEHQTLIVQKKKEIEDL---EIEF-NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ E + + V K +EI D+ ++E N Q +S RDK+V + + + ++Y Q + +
Sbjct: 204 KNEMELK-VEVSKLREISDIARRQVEILNAQQQS--RDKEVESLRMQL-LDYQAQSDEKS 259
Query: 965 QEYKNNIENLNMNVEELNKMN-LELIDKHVQKQQT------QSPDYTEQ--YINEINKLN 1015
K + N+++ + E + LE I +QK + Q D EQ Y + N
Sbjct: 260 LIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRN 319
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
K + I +L ++ + A ++ + + Q + +EM+ ++ + +
Sbjct: 320 RA-KHLRQTIQSLRRQFSGALP--LAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNME 376
Query: 1076 QHNEELQILVREQDDQIKELKETK-----LTFEMNIPKTEGMIISSTIEPMSDDA----- 1125
E+++ ++ ++ I LK+TK + + M I + + E + D
Sbjct: 377 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYL 436
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT-- 1183
NN+ ++ ++ +F +ER + +Q +++ E Q Q E LN
Sbjct: 437 NNIISEYERTISSLEE-EIVQQNKFHEERQMAWDQR-EVDLERQLDIFDRQQNEILNAAQ 494
Query: 1184 ---ELTGHDVVNQEQI-NQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELW 1239
E TG + NQL+ L ++ +L T A +S ++ L
Sbjct: 495 KFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKES--ALRLA 552
Query: 1240 KQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM--EQVTSLQN 1297
+Q++ R+ K +ELR++L A + + + + + + +++ + + + + ++Q
Sbjct: 553 EQNILSRD----KVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQA 608
Query: 1298 KLQDKEEHLRNLQEKYADVIN-QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
+L KEE L+ Q Q EI++ ED + L
Sbjct: 609 RLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSS-------LNKFK 661
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
Q+ + +QS + ++ + ++ K+ +++ LE +
Sbjct: 662 QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDS--LSSLLVKLKKVSQDLERQREIT 719
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTY-----EKESELAILRLKMHENAN 1471
K E+ Q EN ++ + + +EDL Y +KES+ L+ + AN
Sbjct: 720 ELKVKEFENIKLQLQ---ENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN 776
Query: 1472 -HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
T + +ER+K +L +K KQ L++AL E A EM A E +
Sbjct: 777 SRAPTTTMRNLVERLK--SQLALK-------EKQQKALSRALLELRA---EMTAAAEERI 824
Query: 1531 IEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
I + + N+Q +V + +++ V ++ E L + N+E
Sbjct: 825 ISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 873
Score = 54.8 bits (126), Expect = 2e-06
Identities = 172/901 (19%), Positives = 381/901 (42%), Gaps = 87/901 (9%)
Query: 93 SLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIK 152
SL LK+ +E+ ++ EL + I ++ D+ +L + +
Sbjct: 700 SLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQ 759
Query: 153 EKDNAL-SVLQVKMKIME----TTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXX 207
++ L S LQ + + TT+ +L E++ + + E + KA +
Sbjct: 760 KESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAA 819
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
E+ T +E + ++ + L +E + + L+EA K + +
Sbjct: 820 A---EERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSL 876
Query: 268 SLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEE-KTEIEEKGS-LEIANMTELT 325
+ + L EL++ K+ I+ +E K +I+ S L+ +T+
Sbjct: 877 TDNLNDLNNELQKKQKAYNKILRE-----KEEIDQENDELKRQIKRLTSGLQGKPLTD-- 929
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
K L+E L ++++ +LE K+ + + K + + K LI + G+ +K++
Sbjct: 930 NKQSLIEELQRKVKKLENQLEGKVEEV--DLKPMKEKNAK-EELIRWEEGKKWQAKIEGI 986
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
++L K + E+ L + +L KDL K EK T
Sbjct: 987 RNKL-----------KEKEGEVFTLTKQLNTL-KDLFAK--ADKEKLTLQRKLKTTGMTV 1032
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKD--LIE 503
D ++ LE ++ +E N + N+I ++ + ++D+++++ L E
Sbjct: 1033 DQVLGIRALESEKELEELKK----RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE 1088
Query: 504 KLKSAEEQI---TQLNDEIDA--ANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
KL + E+Q T I ++ + + + K LK + I+ ++ +NK++
Sbjct: 1089 KLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLP 1148
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDY-DSGRMIESDVYKKMIEMENLAETRLKAIS 617
RL ++ L + L++EK +Q L SGR K + E+E K +
Sbjct: 1149 RLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-----GKTIPELEKTIGLMKKVVE 1203
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSV--HLEEQIDALSASK 675
++ + L + IL +K+A+I Q +++++ +E++ + HL Q+ SK
Sbjct: 1204 KVQRENEQLKKASGIL------TSEKMANIEQ-ENEKLKAELEKLKAHLGHQLSMHYESK 1256
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
+ E + + E+L K+L+ + D KL+ + N+++ + EKM+ + + E
Sbjct: 1257 TKGT---EKIIAENERLR---KELKKET-DAAEKLR-IAKNNLEILN--EKMTVQ-LEET 1305
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
++ E Q + G D+K + + E++L + ++ I + +SI ++ L
Sbjct: 1306 GKRLQFAESRGPQLE-GADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQ----L 1360
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
++A + ++K Y+E Q+ +++ + + ++ ++++L + N +L K+
Sbjct: 1361 VKEATER----EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEK 1416
Query: 856 QILLE--ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
L+ E Q + L EK DL E++ + + L+ +K++ E
Sbjct: 1417 AELIHQIEANKDQSGAESTIPDADQLKEKIK--DL-ETQLKMSDLEKQHLKEEIKKLKKE 1473
Query: 914 HQTLIVQKKKEIEDLEIEFNTQI-ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
+ +EIEDL+ + ++ ++ + ++KV + +E + + A +E+++ E
Sbjct: 1474 LENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAAS-EEFEDEEE 1532
Query: 973 N 973
+
Sbjct: 1533 S 1533
Score = 35.9 bits (79), Expect = 1.2
Identities = 74/416 (17%), Positives = 160/416 (38%), Gaps = 44/416 (10%)
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV- 1259
S+LE N + + L + ++ + V QR + L ++++ +E + EL +
Sbjct: 21 SELELANKQYNELTAKYRDILQKDNMLV-QRTSNLEHLECENISLKE-QVESINKELEIT 78
Query: 1260 --QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKL----------QDKEEHLR 1307
+L E +EQ S+ ++ K +T + S+ K+ + + EH +
Sbjct: 79 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 138
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE-NQSYKQMQEQS 1366
+ E + Q+E E+E + +L +++ Q
Sbjct: 139 KMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQR 198
Query: 1367 ILNINEENAQLKKSSXXXXXXXXXXXXRVN---------DAEAKVLE---LTHQLELKDS 1414
IL + + +LK +V D E + L L +Q + +
Sbjct: 199 ILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEK 258
Query: 1415 EIYQKTHEYTITLTQRN----DEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMH 1467
+ K H++ ++L + E++ Q++ Y R+E EKE L RL+
Sbjct: 259 SLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGR 318
Query: 1468 ENANHY-ETMQKESEIERVKLIEELNVKITES-VSLNKQVAELNKALEEEVAKTNEMQTA 1525
A H +T+Q L K +++ + L ++ + ++ + M+
Sbjct: 319 NRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENK 378
Query: 1526 LENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
E+++ L + I+ L++ A QK +++ ++ R ++L +N+EL+
Sbjct: 379 TLEMELKLKGLEELISTLKDTKGA-----QKVINWHMKIEELRLQEL--KLNRELV 427
>AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1773
Score = 101 bits (241), Expect = 3e-20
Identities = 171/877 (19%), Positives = 379/877 (43%), Gaps = 86/877 (9%)
Query: 509 EEQITQLND---EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
E ++++L D + + + ++++ + K+M++ N + K + EELH
Sbjct: 770 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 829
Query: 566 HLSQKVAELEEE-KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
QK + ++ GN++ M E ++ K + E++ + I +E
Sbjct: 830 RTVQKRQQQKDFIDGNVE--------SLMTELEIEKSLKHHEDIVDE----IECIEKTLL 877
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQV--CSEIKSVHLEEQIDALSASKKELALVI 682
EL + E E +L+ + + V ++ K L+ + DA ++ +
Sbjct: 878 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 937
Query: 683 ENLKLDKE--QLYGTIKDLENDK---EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+K D++ L KDLE K E+I+ ++ N I D + EK++E L
Sbjct: 938 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEI-NKIVAAKDSDFQCLSKKKEKLTEELQ 996
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K+ + + + + ++E ++ ++ +EL K KS++ ++ +AV+ DR+ ++
Sbjct: 997 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL-DRQLGHKK 1055
Query: 798 KADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL---- 851
+ L GS +Q K + E E+ + +H R V+ L E+ + EL
Sbjct: 1056 EELHLLQGSMVQAKADLQEALRLGETEVTEKC----NHIREVKSLLEELSFQKGELNVQI 1111
Query: 852 -QKKNQILL------EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
++K Q+ L +E +NLQ+ L M +H L N D+ + E+ + Q +
Sbjct: 1112 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL---KNILDMLQLENHELQGLKLQHD 1168
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ + + Q ++++K E+E+L+ + + Q + I +K L E+ ++ IE +T A+
Sbjct: 1169 QRVSEL-EKTQVAVLEEKLELENLQ-QISQQQKGEIEWQKQLLERDKREIERMT---AES 1223
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ---TQSPDYTEQYINEINKLNALLKQK 1021
+ ++ +E L+ E+L + ++ +K + + + + + ++ + + KL +++
Sbjct: 1224 RALQSCVECLSKEKEDLQE-KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKL 1282
Query: 1022 DEEIIALNQ---KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+E+ LN+ ++N + + + + +L N+++ + + LL + +H
Sbjct: 1283 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQ 1342
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+ +L+ EQ K++ E FE + E + + N +
Sbjct: 1343 D---VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQ 1399
Query: 1139 XXXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQL--ETLNTELTGHDVVNQEQ 1195
+ + EE ++ V L+EQ +L EL + +K+ Q+ + L E + +E+
Sbjct: 1400 RLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER 1459
Query: 1196 -INQLKSKLEQ----LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR---E 1247
L+ L Q L+ L+ EL + + D + + L Q L +R E
Sbjct: 1460 WCESLEKTLSQTKRQLSEREQQLVEKSGELLA-LQKEADSMRADFSLLRNQFLTERKKAE 1518
Query: 1248 ADFQKTEHELRVQLSAFESKY-EQLLDSVQSSTQEETNKIVT----------MEQVTSLQ 1296
+ L++Q S E EQ ++ + T ++V M+++ +Q
Sbjct: 1519 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 1578
Query: 1297 NKLQDKEEHLRN---LQEKYADVINQIEILRSEIEDE 1330
+ + ++ + N L+ + ++ + + L+SE++DE
Sbjct: 1579 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDE 1615
Score = 97.9 bits (233), Expect = 3e-19
Identities = 166/860 (19%), Positives = 358/860 (41%), Gaps = 65/860 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
M L + E+ +L +++ ++ E I + L EE+ ++ + +++E N
Sbjct: 756 MGVLHCNVPEHHNLENEVSRL--EDIMQHLKSKKREERWMRASKRQSEKEMEELH---HN 810
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYS---LERKADQLGSYLQ-EKQKAYSEYTIQEDE 822
I+ L + KS C +EE ++ R+ ++ + L + L+ EK + E + E E
Sbjct: 811 IDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIE 870
Query: 823 LVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+ + + + R ++ L E E E ++K + +E+ + + SL + L
Sbjct: 871 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 930
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
+A T + K QLR L+++ K + Q K + E++ E N + +
Sbjct: 931 RAQETAV---NLVKADQQLRSLQADAKDLE--------QHKIKQEEILKEINKIVAAKDS 979
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
D + L++K EK E + +L+ ++ + N ++ +++ L + + L K + ++ +S
Sbjct: 980 DFQCLSKKKEKLTEELQKLQKDIEMAERNEDH---HLQVLKESEVLLQAKRAELEKLKSQ 1036
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
++Q E+ L+ L K EE+ L Q S + +D + L T++
Sbjct: 1037 VTSQQ--QEMAVLDRQLGHKKEELHLL-------QGSMVQAKADLQEALRLGETEVTEKC 1087
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
++ V L + EL + + E+ Q+ +K+ E N+ ++ +
Sbjct: 1088 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL-----QVVLRQMSKH 1142
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+ LK+Q ++ + + + Q A L +L+ + L+ +
Sbjct: 1143 KTELKNILDMLQLENHELQGLKLQHDQRVSE---LEKTQVAVLEEKLE-----LENLQQI 1194
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ + G ++ + + K ++E++ E+ L S V E S + ++ ++W++
Sbjct: 1195 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV-ECLSKEKEDLQEK----CDIWEK 1249
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
LAQ + E +++ S E + Q Q +K+ ++++Q +LQ+
Sbjct: 1250 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1309
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEI------EDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
K E + +LQE+ A+V + + + + ++ +D ++ D + E
Sbjct: 1310 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1369
Query: 1356 NQSYKQMQEQSILNINEEN----AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
++ KQ Q Q + N EEN Q + ++ ++ + E HQLE
Sbjct: 1370 EET-KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE- 1427
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
K+ + + ++ +E Q+ + + +E + + +L+ ++ E +
Sbjct: 1428 KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 1487
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--EEEVAKTNEMQTALENQ 1529
+QKE++ R N +TE KQVA L +AL + + N ++ EN
Sbjct: 1488 ELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENS 1547
Query: 1530 EIEIVTLNDEITNLQNMVRA 1549
I+ E+ N RA
Sbjct: 1548 CIQKEMATIELVAQDNHERA 1567
Score = 80.6 bits (190), Expect = 4e-14
Identities = 201/1015 (19%), Positives = 415/1015 (40%), Gaps = 83/1015 (8%)
Query: 229 EAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
E W + K++ K++E I L + K LE E+ H + + +Q
Sbjct: 789 EERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC---EVEELHRTVQKRQQQKDFIDGN 845
Query: 288 XXXXXXXLA-KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
L ++S++ + EIE + +EL + LL ++ T ++ +
Sbjct: 846 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 905
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
N + T++K ++ + + R++ + +K+ QL S L D K + +++
Sbjct: 906 NAVEKF-TDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRS--LQADA-KDLEQHK 960
Query: 407 IAKLEMVIQSLNKDLV--DKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM--EG 462
I K E +++ +NK + D ++ K KD +A+ +H + E
Sbjct: 961 I-KQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1019
Query: 463 PSLIHV---------GTNTEDVNEIAKVQEQL---KQELND-EIKDVNVK-DLIEKLKSA 508
L+ T E+A + QL K+EL+ + V K DL E L+
Sbjct: 1020 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG 1079
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLK-QMQKTIDNFSKVSDS-NKEIVRLTEELHH 566
E ++T+ + I K++++ S K +L Q+ + + + KE L L
Sbjct: 1080 ETEVTEKCNHIREV-KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ 1138
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA--ETRLKAISLLE---S 621
+S+ EL+ LQL + G ++ D +E +A E +L+ +L +
Sbjct: 1139 MSKHKTELKNILDMLQLENHELQ-GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQ 1197
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID----ALSASKKE 677
QK ++ + +L++ E+E A+ LQS C + L+E+ D L+ +K+
Sbjct: 1198 QKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRV 1257
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
LA EN K+++ L + LE + + +L ++ + L + + M +++ E
Sbjct: 1258 LAAAEENSKMEQSNL----EKLELNVRKLQQELDQLNRDKLSLHNDISAMQ-QQLQEKRE 1312
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
+N ++ Q ++ + ++DL L K + L E + +D +
Sbjct: 1313 AVNSLQEELANVQDHLN--LAKQDL--------LHTTKHQDVLLSEQTRLQKD----ISE 1358
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
A++ +E++ + + ++E+ L+ + + ++ E E E +L+
Sbjct: 1359 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1418
Query: 858 LLEENQNLQISLSDMQQHYNALVEK---ANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
L E+ L+ L+D + + ++ K A E ++ L S KR E
Sbjct: 1419 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 1478
Query: 915 QTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ +V+K E+ L+ E ++ + + ++ + L E+ +K + V L+ L+ ++ +E
Sbjct: 1479 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER-KKAEKQVASLKEALKIQRSQLEK 1537
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE--EIIALNQK 1031
N+ E + N I K + + + D E+ + +LN + + E + +A +
Sbjct: 1538 ---NLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKD 1593
Query: 1032 INNAQVSYMSMVSDYESKLA-QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ Q+ + +S++ + T L+N+ + + + L + NE L +
Sbjct: 1594 LERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL-------EG 1646
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LKE L F MN E + S + M D+ + LK Q
Sbjct: 1647 ELESLKE-NLPFTMNEGPFEEKLNFSQVHIM-DEHWRGEALREKLRHREDRLKAQLRHCM 1704
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ 1205
++ VL + + L ++ L L T T D + ++QL+S L +
Sbjct: 1705 SKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASSPSLSQLESSLTE 1758
Score = 79.8 bits (188), Expect = 7e-14
Identities = 139/695 (20%), Positives = 299/695 (43%), Gaps = 62/695 (8%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
++L D+ +LK E + + K++ +++E E + I+ +++KK L + E+ V
Sbjct: 774 SRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLECEVEELHRTV 832
Query: 958 TQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+ + Q N+E+L + +E+ K + +++D+ ++T + +E+ + +
Sbjct: 833 QKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL-----KRRSELREAD 887
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
LL + + E+ +K NA + +D + L Q + E +E Q + L+ +
Sbjct: 888 RLLAEAESELSCTKEKTKNAVEKF----TDAKRSLLQTESDAEELERRAQETAVNLVKAD 943
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMN----IPKTEGMIISSTIEPMSDDANNV--D 1129
Q LQ ++ + ++K+ ++ E+N ++ +S E ++++ + D
Sbjct: 944 QQLRSLQADAKDLEQH--KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1001
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL--- 1185
++E E +Q +R+ L++ +++ ++ QE QL EL
Sbjct: 1002 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1061
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
G V + + + E TE N + V L +S + +I+E K L
Sbjct: 1062 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER-KTQLTL 1120
Query: 1246 READFQKTEHELRV---QLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNK--- 1298
+ + +K E L+V Q+S +++ + +LD +Q E + K+ ++V+ L+
Sbjct: 1121 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1180
Query: 1299 -LQDKEEHLRNLQEKYADVINQIEILRSEIEDEK------VAFXXXXXXXXXXXXXXXXD 1351
L++K E L NLQ+ +IE + +E +K A D
Sbjct: 1181 VLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1239
Query: 1352 LRTENQSY--KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQ 1408
L+ + + K Q + +L EEN+++++S+ + ++ L L +
Sbjct: 1240 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1299
Query: 1409 LELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE---SELAILRLK 1465
+ ++ +K + +E NV+ L ++ + T ++ SE L+
Sbjct: 1300 ISAMQQQLQEKRE----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1355
Query: 1466 MHENANHYETMQKESEIERVKL------IEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
+ E AN +E QKE E ++ +L IEE +K+ + + ++ L K E E +K
Sbjct: 1356 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR---LQKERESEESKL 1412
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ L+ Q+ + L E+T+ ++ + SK+
Sbjct: 1413 ETSKVTLKEQQHQ---LEKELTDQKSKLDQVLSKV 1444
Score = 73.7 bits (173), Expect = 5e-12
Identities = 133/628 (21%), Positives = 272/628 (43%), Gaps = 77/628 (12%)
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADI-SQLQSD-QVCSEIKSVHLEEQIDALSASKK 676
+++QK Q+L I+ ++Y ++E +L +I S++ + + +++ E QI A A KK
Sbjct: 1 MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKK 60
Query: 677 ELALVIENL-------KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+L VI L K Q + L ++KE ++ +L QE L ++ M A
Sbjct: 61 DLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL--EIVAMDA 118
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
E + + LA++ +S +Q Q ++A +Q+ + +LS Y++ LE + + +
Sbjct: 119 ENMRKELAEL----ESALQEQHEVNASLQQT-------QGDLSAYEAE---LEARLNLRD 164
Query: 790 DRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
L+ + +++ Q +Q A +E + L N L + E E EN
Sbjct: 165 AEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE--------EKEQEN 216
Query: 849 KELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLK 908
EL K + L ++N L+ L D Q H N +V+ R + + + + +L+ L +
Sbjct: 217 SELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK-LGTGEM 275
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
I L K + DL+ +F+ + + K+E++ V + + Q +E
Sbjct: 276 NIHSPSDVL----GKSLADLQKQFS---------EILARSKWERDEAQVRERKLQ-EEMA 321
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
E L EE + ++ + + Q +Q NEI+ L LK EEI
Sbjct: 322 LQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM-EEI--- 377
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
Q + + Q+ + E LAQ + + E + +Q+ + ++L+ V
Sbjct: 378 -QGLTDLQLQEAD--EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATS 434
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL-KVQEE 1147
D +L +LT + K+ + + +++ + L + + E
Sbjct: 435 D----KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 490
Query: 1148 EEFIQERSVLQEQSAKLNTELQE------CYTKIIQLETLNTELTGHDVVNQEQINQLKS 1201
E +Q ++L+++ + E+++ ++++++E LN + + +I +L++
Sbjct: 491 IELLQ--NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMER----QRTEIARLQN 544
Query: 1202 KLEQLNTEN----DNLLSTVAELRSSIS 1225
L+ ++N +N+L +AELR +S
Sbjct: 545 VLDLTGSDNKGGFENVLEEIAELRREVS 572
Score = 72.5 bits (170), Expect = 1e-11
Identities = 153/797 (19%), Positives = 333/797 (41%), Gaps = 75/797 (9%)
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++++ L +R + + E E +EL LL+E ++L+ + ++ + +
Sbjct: 777 EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL---HRTVQ 833
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKR---ITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ + D + T+L ++E +LK I E + + K +L E + +
Sbjct: 834 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELR-EADRLLA 891
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
A + EK + +E T + L + +++ E L +E +NL D+ ++ Q
Sbjct: 892 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQ 950
Query: 998 TQSPDYT------EQYINEINKLNA--------LLKQKD---EEIIALNQKINNAQVS-- 1038
+ D E+ + EINK+ A L K+K+ EE+ L + I A+ +
Sbjct: 951 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1010
Query: 1039 -YMSMVSDYESKLAQFTTKLENMEEEM--QRVSKQLLDSK--QHNEELQILVREQDDQIK 1093
++ ++ + E L +LE ++ ++ Q+ +LD + EEL +L
Sbjct: 1011 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1070
Query: 1094 ELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEE 1149
+L+E E + + I + S +E +S ++ +K +++EEE
Sbjct: 1071 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1130
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q V+ Q +K TEL+ ++QLE N EL G + + +++++L+ Q+
Sbjct: 1131 NLQ---VVLRQMSKHKTELKNILD-MLQLE--NHELQGLKLQHDQRVSELEKT--QVAVL 1182
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA-DFQKTEHELRVQLSAFE--S 1266
+ L EL + + Q+G EI W++ L +R+ + ++ E R S E S
Sbjct: 1183 EEKL-----ELENLQQISQQQKG-EIE--WQKQLLERDKREIERMTAESRALQSCVECLS 1234
Query: 1267 KYEQLLDS---VQSSTQEETNKIVTMEQVTSL--QNKLQDKEEHLRNLQEKYADVINQIE 1321
K ++ L + +T +++ + S Q+ L+ E ++R LQ++ D +N+ +
Sbjct: 1235 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL-DQLNRDK 1293
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + ++ A +L Q + + +Q +L+ + L
Sbjct: 1294 L---SLHNDISAMQQQLQEKREAVNSLQEELANV-QDHLNLAKQDLLHTTKHQDVLLSEQ 1349
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
R D + + QL++ +EI E + L Q+ F+ ++++
Sbjct: 1350 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI----EENKLKLVQQEMMFQRLQKER 1405
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNVKITESV 1499
E ++E + + L ++ + + + + + + ERV+ ++E + ES
Sbjct: 1406 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE-EERWCES- 1463
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
L K +++ + L E + E L + E ++ + + L+N K +K V+
Sbjct: 1464 -LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 1522
Query: 1560 FASDTKQGRDEQLDNTM 1576
+ + + QL+ +
Sbjct: 1523 SLKEALKIQRSQLEKNL 1539
Score = 38.3 bits (85), Expect = 0.23
Identities = 97/558 (17%), Positives = 215/558 (38%), Gaps = 36/558 (6%)
Query: 182 KDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLK 241
K+Q ++ NK E+ K ++ E IA K + + ++
Sbjct: 8 KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVIS 67
Query: 242 DIES-----KDVRISSLEEANKLLEAARFEISLEH-SKLAQELEQXXXXXXXXXXXXXXL 295
++ K + E KL + E L+ +++ QE +Q L
Sbjct: 68 GLQEYLGTIKGQATQAQNECRKLRDEK--ETLLQRLTEVEQERDQLEIVAMDAENMRKEL 125
Query: 296 AKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHL-NCQIRQTNKELENKLATMGT 354
A+ +E + +E+ E+ +++ ++E +L + + Q +ELE
Sbjct: 126 AE--LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 183
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPW-SQLSSETLNQDTDKKINKNEIAKLEMV 413
E A+ + +K + G+ S+ K S+L ++ + D + K ++ +
Sbjct: 184 EQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNH 243
Query: 414 IQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTE 473
+ + LV E V + D ++ + + G SL +
Sbjct: 244 LNHVVDGLVRPEEVAARVDELRRKLKLGT-------GEMNIHSPSDVLGKSLADLQKQFS 296
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
++ +K + Q ++++ EKL + +E+ Q + A N K H
Sbjct: 297 EILARSKWERDEAQVRERKLQEEMALQQ-EKLATGQEEFRQACERALEARMNFDK--RQH 353
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+ +++QM+ I + S +EI LT+ ++ E +EEK + L + + +
Sbjct: 354 EARIQQMENEIHYLQENLKSMEEIQGLTD------LQLQEADEEKERILAQLRELEKKKK 407
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
+E ++ + + +LK ++ S K EL I + + + + I+Q +++
Sbjct: 408 LEDAKSQEQVFGLDKELKKLKK-AVATSDKL-ATAELTIAKDQLKSLHGTVMKINQERAE 465
Query: 654 QVC-SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
++ +E S + L+ ++ E+ L ++NL K + + LE +K + +
Sbjct: 466 ELQEAERFSRKAAQAARDLTRAEAEIEL-LQNLLRQKGEQF----RLEMEKTGVGTGANS 520
Query: 713 YIQENMDLTDKLEKMSAE 730
+ E L + +E+ E
Sbjct: 521 QVLEIEKLNETMERQRTE 538
Score = 35.1 bits (77), Expect = 2.1
Identities = 37/171 (21%), Positives = 79/171 (46%), Gaps = 15/171 (8%)
Query: 1410 ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
E+KD E Q T + E V L EY I+ + ++E LR
Sbjct: 39 EIKDLE-EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR------ 91
Query: 1470 ANHYETM-QKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
+ ET+ Q+ +E+E+ + ++L + ++ ++ K++AEL AL+E+ +E+ +L+
Sbjct: 92 -DEKETLLQRLTEVEQER--DQLEIVAMDAENMRKELAELESALQEQ----HEVNASLQQ 144
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ ++ E+ N+ A ++++++ + + Q L + KE
Sbjct: 145 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 195
>AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110kDa
protein.
Length = 2325
Score = 101 bits (241), Expect = 3e-20
Identities = 171/877 (19%), Positives = 379/877 (43%), Gaps = 86/877 (9%)
Query: 509 EEQITQLND---EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
E ++++L D + + + ++++ + K+M++ N + K + EELH
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
Query: 566 HLSQKVAELEEE-KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
QK + ++ GN++ M E ++ K + E++ + I +E
Sbjct: 1382 RTVQKRQQQKDFIDGNVE--------SLMTELEIEKSLKHHEDIVDE----IECIEKTLL 1429
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQV--CSEIKSVHLEEQIDALSASKKELALVI 682
EL + E E +L+ + + V ++ K L+ + DA ++ +
Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
Query: 683 ENLKLDKE--QLYGTIKDLENDK---EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+K D++ L KDLE K E+I+ ++ N I D + EK++E L
Sbjct: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEI-NKIVAAKDSDFQCLSKKKEKLTEELQ 1548
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K+ + + + + ++E ++ ++ +EL K KS++ ++ +AV+ DR+ ++
Sbjct: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL-DRQLGHKK 1607
Query: 798 KADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL---- 851
+ L GS +Q K + E E+ + +H R V+ L E+ + EL
Sbjct: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKC----NHIREVKSLLEELSFQKGELNVQI 1663
Query: 852 -QKKNQILL------EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
++K Q+ L +E +NLQ+ L M +H L N D+ + E+ + Q +
Sbjct: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL---KNILDMLQLENHELQGLKLQHD 1720
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ + + Q ++++K E+E+L+ + + Q + I +K L E+ ++ IE +T A+
Sbjct: 1721 QRVSEL-EKTQVAVLEEKLELENLQ-QISQQQKGEIEWQKQLLERDKREIERMT---AES 1775
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ---TQSPDYTEQYINEINKLNALLKQK 1021
+ ++ +E L+ E+L + ++ +K + + + + + ++ + + KL +++
Sbjct: 1776 RALQSCVECLSKEKEDLQE-KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKL 1834
Query: 1022 DEEIIALNQ---KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+E+ LN+ ++N + + + + +L N+++ + + LL + +H
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQ 1894
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+ +L+ EQ K++ E FE + E + + N +
Sbjct: 1895 D---VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQ 1951
Query: 1139 XXXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQL--ETLNTELTGHDVVNQEQ 1195
+ + EE ++ V L+EQ +L EL + +K+ Q+ + L E + +E+
Sbjct: 1952 RLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER 2011
Query: 1196 -INQLKSKLEQ----LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR---E 1247
L+ L Q L+ L+ EL + + D + + L Q L +R E
Sbjct: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLA-LQKEADSMRADFSLLRNQFLTERKKAE 2070
Query: 1248 ADFQKTEHELRVQLSAFESKY-EQLLDSVQSSTQEETNKIVT----------MEQVTSLQ 1296
+ L++Q S E EQ ++ + T ++V M+++ +Q
Sbjct: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 2130
Query: 1297 NKLQDKEEHLRN---LQEKYADVINQIEILRSEIEDE 1330
+ + ++ + N L+ + ++ + + L+SE++DE
Sbjct: 2131 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDE 2167
Score = 99.5 bits (237), Expect = 9e-20
Identities = 160/755 (21%), Positives = 342/755 (45%), Gaps = 90/755 (11%)
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
D ++D +K+ +A+ ++++L+DEI+ A + +++ + KQ+++ I K+S++
Sbjct: 436 DTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE----EFKQLEEAIQ-LKKISEAG 490
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD---SGRMIESDVYKKMIEMENLAET 611
K++ L ++L Q V +L +E +L+L + +G+ + ++ I +++L ++
Sbjct: 491 KDL--LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK--QKEIKDLQIAIDSL-DS 545
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI-SQLQSD-QVCSEIKSVHLEEQID 669
+ S +++QK Q+L I+ ++Y ++E +L +I S++ + + +++ E QI
Sbjct: 546 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIA 605
Query: 670 ALSASKKELALVIENL-------KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
A A KK+L VI L K Q + L ++KE ++ +L QE L
Sbjct: 606 ANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL-- 663
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
++ M AE + + LA++ +S +Q Q ++A +Q+ + +LS Y++ LE
Sbjct: 664 EIVAMDAENMRKELAEL----ESALQEQHEVNASLQQT-------QGDLSAYEAE---LE 709
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDELVNRLAVLMDHDRVVEKQL 841
+ + + L+ + +++ Q +Q A +E + L N L +
Sbjct: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE------- 762
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
E E EN EL K + L ++N L+ L D Q H N +V+ R + + + + +L+
Sbjct: 763 -EKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
L + I L K + DL+ +F+ + + K+E++ V + +
Sbjct: 822 -LGTGEMNIHSPSDVL----GKSLADLQKQFS---------EILARSKWERDEAQVRERK 867
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
Q +E E L EE + ++ + + Q +Q NEI+ L LK
Sbjct: 868 LQ-EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM 926
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
EEI Q + + Q+ + E LAQ + + E + +Q+ + ++L
Sbjct: 927 -EEI----QGLTDLQLQEAD--EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKL 979
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V D +L +LT + K+ + + +++ +
Sbjct: 980 KKAVATSD----KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035
Query: 1142 L-KVQEEEEFIQERSVLQEQSAKLNTELQE------CYTKIIQLETLNTELTGHDVVNQE 1194
L + + E E +Q ++L+++ + E+++ ++++++E LN + +
Sbjct: 1036 LTRAEAEIELLQ--NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMER----QRT 1089
Query: 1195 QINQLKSKLEQLNTEN----DNLLSTVAELRSSIS 1225
+I +L++ L+ ++N +N+L +AELR +S
Sbjct: 1090 EIARLQNVLDLTGSDNKGGFENVLEEIAELRREVS 1124
Score = 97.9 bits (233), Expect = 3e-19
Identities = 166/860 (19%), Positives = 358/860 (41%), Gaps = 65/860 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
M L + E+ +L +++ ++ E I + L EE+ ++ + +++E N
Sbjct: 1308 MGVLHCNVPEHHNLENEVSRL--EDIMQHLKSKKREERWMRASKRQSEKEMEELH---HN 1362
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYS---LERKADQLGSYLQ-EKQKAYSEYTIQEDE 822
I+ L + KS C +EE ++ R+ ++ + L + L+ EK + E + E E
Sbjct: 1363 IDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIE 1422
Query: 823 LVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+ + + + R ++ L E E E ++K + +E+ + + SL + L
Sbjct: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
+A T + K QLR L+++ K + Q K + E++ E N + +
Sbjct: 1483 RAQETAV---NLVKADQQLRSLQADAKDLE--------QHKIKQEEILKEINKIVAAKDS 1531
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
D + L++K EK E + +L+ ++ + N ++ +++ L + + L K + ++ +S
Sbjct: 1532 DFQCLSKKKEKLTEELQKLQKDIEMAERNEDH---HLQVLKESEVLLQAKRAELEKLKSQ 1588
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
++Q E+ L+ L K EE+ L Q S + +D + L T++
Sbjct: 1589 VTSQQ--QEMAVLDRQLGHKKEELHLL-------QGSMVQAKADLQEALRLGETEVTEKC 1639
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
++ V L + EL + + E+ Q+ +K+ E N+ ++ +
Sbjct: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL-----QVVLRQMSKH 1694
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+ LK+Q ++ + + + Q A L +L+ + L+ +
Sbjct: 1695 KTELKNILDMLQLENHELQGLKLQHDQRVSE---LEKTQVAVLEEKLE-----LENLQQI 1746
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ + G ++ + + K ++E++ E+ L S V E S + ++ ++W++
Sbjct: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV-ECLSKEKEDLQEK----CDIWEK 1801
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
LAQ + E +++ S E + Q Q +K+ ++++Q +LQ+
Sbjct: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEI------EDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
K E + +LQE+ A+V + + + + ++ +D ++ D + E
Sbjct: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
Query: 1356 NQSYKQMQEQSILNINEEN----AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
++ KQ Q Q + N EEN Q + ++ ++ + E HQLE
Sbjct: 1922 EET-KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE- 1979
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
K+ + + ++ +E Q+ + + +E + + +L+ ++ E +
Sbjct: 1980 KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 2039
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--EEEVAKTNEMQTALENQ 1529
+QKE++ R N +TE KQVA L +AL + + N ++ EN
Sbjct: 2040 ELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENS 2099
Query: 1530 EIEIVTLNDEITNLQNMVRA 1549
I+ E+ N RA
Sbjct: 2100 CIQKEMATIELVAQDNHERA 2119
Score = 80.6 bits (190), Expect = 4e-14
Identities = 201/1015 (19%), Positives = 415/1015 (40%), Gaps = 83/1015 (8%)
Query: 229 EAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
E W + K++ K++E I L + K LE E+ H + + +Q
Sbjct: 1341 EERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC---EVEELHRTVQKRQQQKDFIDGN 1397
Query: 288 XXXXXXXLA-KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
L ++S++ + EIE + +EL + LL ++ T ++ +
Sbjct: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
N + T++K ++ + + R++ + +K+ QL S L D K + +++
Sbjct: 1458 NAVEKF-TDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRS--LQADA-KDLEQHK 1512
Query: 407 IAKLEMVIQSLNKDLV--DKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM--EG 462
I K E +++ +NK + D ++ K KD +A+ +H + E
Sbjct: 1513 I-KQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1571
Query: 463 PSLIHV---------GTNTEDVNEIAKVQEQL---KQELND-EIKDVNVK-DLIEKLKSA 508
L+ T E+A + QL K+EL+ + V K DL E L+
Sbjct: 1572 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG 1631
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLK-QMQKTIDNFSKVSDS-NKEIVRLTEELHH 566
E ++T+ + I K++++ S K +L Q+ + + + KE L L
Sbjct: 1632 ETEVTEKCNHIREV-KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ 1690
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA--ETRLKAISLLE---S 621
+S+ EL+ LQL + G ++ D +E +A E +L+ +L +
Sbjct: 1691 MSKHKTELKNILDMLQLENHELQ-GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQ 1749
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID----ALSASKKE 677
QK ++ + +L++ E+E A+ LQS C + L+E+ D L+ +K+
Sbjct: 1750 QKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRV 1809
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
LA EN K+++ L + LE + + +L ++ + L + + M +++ E
Sbjct: 1810 LAAAEENSKMEQSNL----EKLELNVRKLQQELDQLNRDKLSLHNDISAMQ-QQLQEKRE 1864
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
+N ++ Q ++ + ++DL L K + L E + +D +
Sbjct: 1865 AVNSLQEELANVQDHLN--LAKQDL--------LHTTKHQDVLLSEQTRLQKD----ISE 1910
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
A++ +E++ + + ++E+ L+ + + ++ E E E +L+
Sbjct: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
Query: 858 LLEENQNLQISLSDMQQHYNALVEK---ANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
L E+ L+ L+D + + ++ K A E ++ L S KR E
Sbjct: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
Query: 915 QTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ +V+K E+ L+ E ++ + + ++ + L E+ +K + V L+ L+ ++ +E
Sbjct: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER-KKAEKQVASLKEALKIQRSQLEK 2089
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE--EIIALNQK 1031
N+ E + N I K + + + D E+ + +LN + + E + +A +
Sbjct: 2090 ---NLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKD 2145
Query: 1032 INNAQVSYMSMVSDYESKLA-QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ Q+ + +S++ + T L+N+ + + + L + NE L +
Sbjct: 2146 LERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL-------EG 2198
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LKE L F MN E + S + M D+ + LK Q
Sbjct: 2199 ELESLKE-NLPFTMNEGPFEEKLNFSQVHIM-DEHWRGEALREKLRHREDRLKAQLRHCM 2256
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ 1205
++ VL + + L ++ L L T T D + ++QL+S L +
Sbjct: 2257 SKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASSPSLSQLESSLTE 2310
Score = 79.8 bits (188), Expect = 7e-14
Identities = 139/695 (20%), Positives = 299/695 (43%), Gaps = 62/695 (8%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
++L D+ +LK E + + K++ +++E E + I+ +++KK L + E+ V
Sbjct: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLECEVEELHRTV 1384
Query: 958 TQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+ + Q N+E+L + +E+ K + +++D+ ++T + +E+ + +
Sbjct: 1385 QKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL-----KRRSELREAD 1439
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
LL + + E+ +K NA + +D + L Q + E +E Q + L+ +
Sbjct: 1440 RLLAEAESELSCTKEKTKNAVEKF----TDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMN----IPKTEGMIISSTIEPMSDDANNV--D 1129
Q LQ ++ + ++K+ ++ E+N ++ +S E ++++ + D
Sbjct: 1496 QQLRSLQADAKDLEQH--KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL--- 1185
++E E +Q +R+ L++ +++ ++ QE QL EL
Sbjct: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
G V + + + E TE N + V L +S + +I+E K L
Sbjct: 1614 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER-KTQLTL 1672
Query: 1246 READFQKTEHELRV---QLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNK--- 1298
+ + +K E L+V Q+S +++ + +LD +Q E + K+ ++V+ L+
Sbjct: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
Query: 1299 -LQDKEEHLRNLQEKYADVINQIEILRSEIEDEK------VAFXXXXXXXXXXXXXXXXD 1351
L++K E L NLQ+ +IE + +E +K A D
Sbjct: 1733 VLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
Query: 1352 LRTENQSY--KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQ 1408
L+ + + K Q + +L EEN+++++S+ + ++ L L +
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
Query: 1409 LELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE---SELAILRLK 1465
+ ++ +K + +E NV+ L ++ + T ++ SE L+
Sbjct: 1852 ISAMQQQLQEKRE----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1907
Query: 1466 MHENANHYETMQKESEIERVKL------IEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
+ E AN +E QKE E ++ +L IEE +K+ + + ++ L K E E +K
Sbjct: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR---LQKERESEESKL 1964
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ L+ Q+ + L E+T+ ++ + SK+
Sbjct: 1965 ETSKVTLKEQQHQ---LEKELTDQKSKLDQVLSKV 1996
Score = 72.5 bits (170), Expect = 1e-11
Identities = 153/797 (19%), Positives = 333/797 (41%), Gaps = 75/797 (9%)
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++++ L +R + + E E +EL LL+E ++L+ + ++ + +
Sbjct: 1329 EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL---HRTVQ 1385
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKR---ITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ + D + T+L ++E +LK I E + + K +L E + +
Sbjct: 1386 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELR-EADRLLA 1443
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
A + EK + +E T + L + +++ E L +E +NL D+ ++ Q
Sbjct: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQ 1502
Query: 998 TQSPDYT------EQYINEINKLNA--------LLKQKD---EEIIALNQKINNAQVS-- 1038
+ D E+ + EINK+ A L K+K+ EE+ L + I A+ +
Sbjct: 1503 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
Query: 1039 -YMSMVSDYESKLAQFTTKLENMEEEM--QRVSKQLLDSK--QHNEELQILVREQDDQIK 1093
++ ++ + E L +LE ++ ++ Q+ +LD + EEL +L
Sbjct: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
Query: 1094 ELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEE 1149
+L+E E + + I + S +E +S ++ +K +++EEE
Sbjct: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1682
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q V+ Q +K TEL+ ++QLE N EL G + + +++++L+ Q+
Sbjct: 1683 NLQ---VVLRQMSKHKTELKNILD-MLQLE--NHELQGLKLQHDQRVSELEKT--QVAVL 1734
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA-DFQKTEHELRVQLSAFE--S 1266
+ L EL + + Q+G EI W++ L +R+ + ++ E R S E S
Sbjct: 1735 EEKL-----ELENLQQISQQQKG-EIE--WQKQLLERDKREIERMTAESRALQSCVECLS 1786
Query: 1267 KYEQLLDS---VQSSTQEETNKIVTMEQVTSL--QNKLQDKEEHLRNLQEKYADVINQIE 1321
K ++ L + +T +++ + S Q+ L+ E ++R LQ++ D +N+ +
Sbjct: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL-DQLNRDK 1845
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + ++ A +L Q + + +Q +L+ + L
Sbjct: 1846 L---SLHNDISAMQQQLQEKREAVNSLQEELANV-QDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
R D + + QL++ +EI E + L Q+ F+ ++++
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI----EENKLKLVQQEMMFQRLQKER 1957
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNVKITESV 1499
E ++E + + L ++ + + + + + + ERV+ ++E + ES
Sbjct: 1958 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE-EERWCES- 2015
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
L K +++ + L E + E L + E ++ + + L+N K +K V+
Sbjct: 2016 -LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
Query: 1560 FASDTKQGRDEQLDNTM 1576
+ + + QL+ +
Sbjct: 2075 SLKEALKIQRSQLEKNL 2091
Score = 55.2 bits (127), Expect = 2e-06
Identities = 90/494 (18%), Positives = 220/494 (44%), Gaps = 35/494 (7%)
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ SL ++++ L +K T+ +S+ T++ ++++ + K + E + +K+
Sbjct: 266 RFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEE----AMLQKQSC 321
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN--IENLNMNVEELNK 983
E+L+ + NT+ E + L +K E LE +L YK + E LN E +
Sbjct: 322 EELKSDLNTKNELLKQKTIELTRACQKQYE----LEQELAFYKIDAKFEPLNYYPSEYAE 377
Query: 984 MNLELIDK-HVQKQQTQSPDY-TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
++ + ++ K + + + TE YI + + + K + +E + + +
Sbjct: 378 IDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDT 437
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ--ILVREQDDQIKELKETK 1099
+ D E K++ T+L + +E+++ +Q+L + + ++L+ I +++ + K+L +
Sbjct: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
Query: 1100 LTFEM---NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQER 1154
L+ + N + E + + +E + L K + ++
Sbjct: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 557
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDNL 1213
S ++Q +N + Q+ +++ ++ + + T +EQ+ + + + E L + + +
Sbjct: 558 SGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 617
Query: 1214 LSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+S + E +I Q E +L K+ L QR + ++ +L + E+ ++L
Sbjct: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
Query: 1272 LDSVQSSTQEETNKIVTMEQV--------TSLQNKLQDKEEHLRNLQEKYADV--INQIE 1321
+ ++S+ QE+ +++Q L+ +L ++ L+E+ V + Q+E
Sbjct: 678 AE-LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLE 736
Query: 1322 --ILRSEIEDEKVA 1333
L++E+E E+ A
Sbjct: 737 QSALQAELEKERQA 750
Score = 35.9 bits (79), Expect = 1.2
Identities = 105/652 (16%), Positives = 260/652 (39%), Gaps = 41/652 (6%)
Query: 952 KNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
K +Y+ LE ++ E N NL +E+L+K+ L+L + ++ + + E N
Sbjct: 113 KKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKL-LKLRELNLSYNKISKIEGIENMCN- 170
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQV-----SYMSMVSDYES-KLAQFTTKLENMEEEM 1064
+ KLN + + + L +K+ + +V + +S + D K Q L +E +
Sbjct: 171 LQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPV 230
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN-IPKTEGMIISSTIEPMSD 1123
+ L + H L+ L Q ++ +E F + + + E + IE ++
Sbjct: 231 VTLPHYLQFTIFHLRSLESL-EGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIE--TE 287
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT 1183
+ + L +EE + ++ +E + LNT+ + K I+L
Sbjct: 288 ELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ 347
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNL--LSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ +++ + ++ +K E LN + + I + +R E +
Sbjct: 348 KQ--YELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYII 405
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
AQ +K E + +++ + LD+ +++ + T +++ L ++++
Sbjct: 406 DSAQA-VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQT--RLSELHDEIEK 462
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
E+ + E++ + I++ + + + + L E Q KQ
Sbjct: 463 AEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQ 522
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
QE + ++ Q+ S + + L++ ++ + ++ +
Sbjct: 523 KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK---QYQQLESRLD 579
Query: 1422 EYTITLTQRNDEFENVRQQLVE--------YEKRIEDLTYEKESELAILRLKMHENANHY 1473
E + + +E +++ +QL E +K +E + + L ++ + + N
Sbjct: 580 EILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC 639
Query: 1474 ETMQKESE--IERVKLIEE----LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
++ E E ++R+ +E+ L + ++ ++ K++AEL AL+E+ +E+ +L+
Sbjct: 640 RKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ----HEVNASLQ 695
Query: 1528 NQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ ++ E+ N+ A ++++++ + + Q L + KE
Sbjct: 696 QTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
>AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein.
Length = 1793
Score = 101 bits (241), Expect = 3e-20
Identities = 171/877 (19%), Positives = 379/877 (43%), Gaps = 86/877 (9%)
Query: 509 EEQITQLND---EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
E ++++L D + + + ++++ + K+M++ N + K + EELH
Sbjct: 790 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 849
Query: 566 HLSQKVAELEEE-KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
QK + ++ GN++ M E ++ K + E++ + I +E
Sbjct: 850 RTVQKRQQQKDFIDGNVE--------SLMTELEIEKSLKHHEDIVDE----IECIEKTLL 897
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQV--CSEIKSVHLEEQIDALSASKKELALVI 682
EL + E E +L+ + + V ++ K L+ + DA ++ +
Sbjct: 898 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 957
Query: 683 ENLKLDKE--QLYGTIKDLENDK---EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+K D++ L KDLE K E+I+ ++ N I D + EK++E L
Sbjct: 958 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEI-NKIVAAKDSDFQCLSKKKEKLTEELQ 1016
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K+ + + + + ++E ++ ++ +EL K KS++ ++ +AV+ DR+ ++
Sbjct: 1017 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL-DRQLGHKK 1075
Query: 798 KADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL---- 851
+ L GS +Q K + E E+ + +H R V+ L E+ + EL
Sbjct: 1076 EELHLLQGSMVQAKADLQEALRLGETEVTEKC----NHIREVKSLLEELSFQKGELNVQI 1131
Query: 852 -QKKNQILL------EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
++K Q+ L +E +NLQ+ L M +H L N D+ + E+ + Q +
Sbjct: 1132 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL---KNILDMLQLENHELQGLKLQHD 1188
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ + + Q ++++K E+E+L+ + + Q + I +K L E+ ++ IE +T A+
Sbjct: 1189 QRVSEL-EKTQVAVLEEKLELENLQ-QISQQQKGEIEWQKQLLERDKREIERMT---AES 1243
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ---TQSPDYTEQYINEINKLNALLKQK 1021
+ ++ +E L+ E+L + ++ +K + + + + + ++ + + KL +++
Sbjct: 1244 RALQSCVECLSKEKEDLQE-KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKL 1302
Query: 1022 DEEIIALNQ---KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+E+ LN+ ++N + + + + +L N+++ + + LL + +H
Sbjct: 1303 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQ 1362
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+ +L+ EQ K++ E FE + E + + N +
Sbjct: 1363 D---VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQ 1419
Query: 1139 XXXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQL--ETLNTELTGHDVVNQEQ 1195
+ + EE ++ V L+EQ +L EL + +K+ Q+ + L E + +E+
Sbjct: 1420 RLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER 1479
Query: 1196 -INQLKSKLEQ----LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR---E 1247
L+ L Q L+ L+ EL + + D + + L Q L +R E
Sbjct: 1480 WCESLEKTLSQTKRQLSEREQQLVEKSGELLA-LQKEADSMRADFSLLRNQFLTERKKAE 1538
Query: 1248 ADFQKTEHELRVQLSAFESKY-EQLLDSVQSSTQEETNKIVT----------MEQVTSLQ 1296
+ L++Q S E EQ ++ + T ++V M+++ +Q
Sbjct: 1539 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 1598
Query: 1297 NKLQDKEEHLRN---LQEKYADVINQIEILRSEIEDE 1330
+ + ++ + N L+ + ++ + + L+SE++DE
Sbjct: 1599 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDE 1635
Score = 97.9 bits (233), Expect = 3e-19
Identities = 166/860 (19%), Positives = 358/860 (41%), Gaps = 65/860 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
M L + E+ +L +++ ++ E I + L EE+ ++ + +++E N
Sbjct: 776 MGVLHCNVPEHHNLENEVSRL--EDIMQHLKSKKREERWMRASKRQSEKEMEELH---HN 830
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYS---LERKADQLGSYLQ-EKQKAYSEYTIQEDE 822
I+ L + KS C +EE ++ R+ ++ + L + L+ EK + E + E E
Sbjct: 831 IDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIE 890
Query: 823 LVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+ + + + R ++ L E E E ++K + +E+ + + SL + L
Sbjct: 891 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 950
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
+A T + K QLR L+++ K + Q K + E++ E N + +
Sbjct: 951 RAQETAV---NLVKADQQLRSLQADAKDLE--------QHKIKQEEILKEINKIVAAKDS 999
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
D + L++K EK E + +L+ ++ + N ++ +++ L + + L K + ++ +S
Sbjct: 1000 DFQCLSKKKEKLTEELQKLQKDIEMAERNEDH---HLQVLKESEVLLQAKRAELEKLKSQ 1056
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
++Q E+ L+ L K EE+ L Q S + +D + L T++
Sbjct: 1057 VTSQQ--QEMAVLDRQLGHKKEELHLL-------QGSMVQAKADLQEALRLGETEVTEKC 1107
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
++ V L + EL + + E+ Q+ +K+ E N+ ++ +
Sbjct: 1108 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL-----QVVLRQMSKH 1162
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+ LK+Q ++ + + + Q A L +L+ + L+ +
Sbjct: 1163 KTELKNILDMLQLENHELQGLKLQHDQRVSE---LEKTQVAVLEEKLE-----LENLQQI 1214
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ + G ++ + + K ++E++ E+ L S V E S + ++ ++W++
Sbjct: 1215 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV-ECLSKEKEDLQEK----CDIWEK 1269
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
LAQ + E +++ S E + Q Q +K+ ++++Q +LQ+
Sbjct: 1270 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1329
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEI------EDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
K E + +LQE+ A+V + + + + ++ +D ++ D + E
Sbjct: 1330 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1389
Query: 1356 NQSYKQMQEQSILNINEEN----AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
++ KQ Q Q + N EEN Q + ++ ++ + E HQLE
Sbjct: 1390 EET-KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE- 1447
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
K+ + + ++ +E Q+ + + +E + + +L+ ++ E +
Sbjct: 1448 KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 1507
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--EEEVAKTNEMQTALENQ 1529
+QKE++ R N +TE KQVA L +AL + + N ++ EN
Sbjct: 1508 ELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENS 1567
Query: 1530 EIEIVTLNDEITNLQNMVRA 1549
I+ E+ N RA
Sbjct: 1568 CIQKEMATIELVAQDNHERA 1587
Score = 80.6 bits (190), Expect = 4e-14
Identities = 201/1015 (19%), Positives = 415/1015 (40%), Gaps = 83/1015 (8%)
Query: 229 EAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
E W + K++ K++E I L + K LE E+ H + + +Q
Sbjct: 809 EERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC---EVEELHRTVQKRQQQKDFIDGN 865
Query: 288 XXXXXXXLA-KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
L ++S++ + EIE + +EL + LL ++ T ++ +
Sbjct: 866 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 925
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
N + T++K ++ + + R++ + +K+ QL S L D K + +++
Sbjct: 926 NAVEKF-TDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRS--LQADA-KDLEQHK 980
Query: 407 IAKLEMVIQSLNKDLV--DKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM--EG 462
I K E +++ +NK + D ++ K KD +A+ +H + E
Sbjct: 981 I-KQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1039
Query: 463 PSLIHV---------GTNTEDVNEIAKVQEQL---KQELND-EIKDVNVK-DLIEKLKSA 508
L+ T E+A + QL K+EL+ + V K DL E L+
Sbjct: 1040 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG 1099
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLK-QMQKTIDNFSKVSDS-NKEIVRLTEELHH 566
E ++T+ + I K++++ S K +L Q+ + + + KE L L
Sbjct: 1100 ETEVTEKCNHIREV-KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ 1158
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA--ETRLKAISLLE---S 621
+S+ EL+ LQL + G ++ D +E +A E +L+ +L +
Sbjct: 1159 MSKHKTELKNILDMLQLENHELQ-GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQ 1217
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID----ALSASKKE 677
QK ++ + +L++ E+E A+ LQS C + L+E+ D L+ +K+
Sbjct: 1218 QKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRV 1277
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
LA EN K+++ L + LE + + +L ++ + L + + M +++ E
Sbjct: 1278 LAAAEENSKMEQSNL----EKLELNVRKLQQELDQLNRDKLSLHNDISAMQ-QQLQEKRE 1332
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
+N ++ Q ++ + ++DL L K + L E + +D +
Sbjct: 1333 AVNSLQEELANVQDHLN--LAKQDL--------LHTTKHQDVLLSEQTRLQKD----ISE 1378
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
A++ +E++ + + ++E+ L+ + + ++ E E E +L+
Sbjct: 1379 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1438
Query: 858 LLEENQNLQISLSDMQQHYNALVEK---ANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
L E+ L+ L+D + + ++ K A E ++ L S KR E
Sbjct: 1439 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 1498
Query: 915 QTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ +V+K E+ L+ E ++ + + ++ + L E+ +K + V L+ L+ ++ +E
Sbjct: 1499 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER-KKAEKQVASLKEALKIQRSQLEK 1557
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE--EIIALNQK 1031
N+ E + N I K + + + D E+ + +LN + + E + +A +
Sbjct: 1558 ---NLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKD 1613
Query: 1032 INNAQVSYMSMVSDYESKLA-QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ Q+ + +S++ + T L+N+ + + + L + NE L +
Sbjct: 1614 LERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL-------EG 1666
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LKE L F MN E + S + M D+ + LK Q
Sbjct: 1667 ELESLKE-NLPFTMNEGPFEEKLNFSQVHIM-DEHWRGEALREKLRHREDRLKAQLRHCM 1724
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ 1205
++ VL + + L ++ L L T T D + ++QL+S L +
Sbjct: 1725 SKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASSPSLSQLESSLTE 1778
Score = 79.8 bits (188), Expect = 7e-14
Identities = 139/695 (20%), Positives = 299/695 (43%), Gaps = 62/695 (8%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
++L D+ +LK E + + K++ +++E E + I+ +++KK L + E+ V
Sbjct: 794 SRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLECEVEELHRTV 852
Query: 958 TQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+ + Q N+E+L + +E+ K + +++D+ ++T + +E+ + +
Sbjct: 853 QKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL-----KRRSELREAD 907
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
LL + + E+ +K NA + +D + L Q + E +E Q + L+ +
Sbjct: 908 RLLAEAESELSCTKEKTKNAVEKF----TDAKRSLLQTESDAEELERRAQETAVNLVKAD 963
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMN----IPKTEGMIISSTIEPMSDDANNV--D 1129
Q LQ ++ + ++K+ ++ E+N ++ +S E ++++ + D
Sbjct: 964 QQLRSLQADAKDLEQH--KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1021
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL--- 1185
++E E +Q +R+ L++ +++ ++ QE QL EL
Sbjct: 1022 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1081
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
G V + + + E TE N + V L +S + +I+E K L
Sbjct: 1082 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER-KTQLTL 1140
Query: 1246 READFQKTEHELRV---QLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNK--- 1298
+ + +K E L+V Q+S +++ + +LD +Q E + K+ ++V+ L+
Sbjct: 1141 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1200
Query: 1299 -LQDKEEHLRNLQEKYADVINQIEILRSEIEDEK------VAFXXXXXXXXXXXXXXXXD 1351
L++K E L NLQ+ +IE + +E +K A D
Sbjct: 1201 VLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1259
Query: 1352 LRTENQSY--KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQ 1408
L+ + + K Q + +L EEN+++++S+ + ++ L L +
Sbjct: 1260 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1319
Query: 1409 LELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE---SELAILRLK 1465
+ ++ +K + +E NV+ L ++ + T ++ SE L+
Sbjct: 1320 ISAMQQQLQEKRE----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1375
Query: 1466 MHENANHYETMQKESEIERVKL------IEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
+ E AN +E QKE E ++ +L IEE +K+ + + ++ L K E E +K
Sbjct: 1376 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR---LQKERESEESKL 1432
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ L+ Q+ + L E+T+ ++ + SK+
Sbjct: 1433 ETSKVTLKEQQHQ---LEKELTDQKSKLDQVLSKV 1464
Score = 74.1 bits (174), Expect = 4e-12
Identities = 134/630 (21%), Positives = 273/630 (43%), Gaps = 77/630 (12%)
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADI-SQLQSD-QVCSEIKSVHLEEQIDALSAS 674
S +++QK Q+L I+ ++Y ++E +L +I S++ + + +++ E QI A A
Sbjct: 25 SHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEAL 84
Query: 675 KKELALVIENL-------KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
KK+L VI L K Q + L ++KE ++ +L QE L ++ M
Sbjct: 85 KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL--EIVAM 142
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
AE + + LA++ +S +Q Q ++A +Q+ + +LS Y++ LE + +
Sbjct: 143 DAENMRKELAEL----ESALQEQHEVNASLQQT-------QGDLSAYEAE---LEARLNL 188
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH 846
+ L+ + +++ Q +Q A +E + L N L + E E
Sbjct: 189 RDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE--------EKEQ 240
Query: 847 ENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN 906
EN EL K + L ++N L+ L D Q H N +V+ R + + + + +L+ L +
Sbjct: 241 ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK-LGTG 299
Query: 907 LKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
I L K + DL+ +F+ + + K+E++ V + + Q +E
Sbjct: 300 EMNIHSPSDVL----GKSLADLQKQFS---------EILARSKWERDEAQVRERKLQ-EE 345
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
E L EE + ++ + + Q +Q NEI+ L LK EEI
Sbjct: 346 MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM-EEI- 403
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVR 1086
Q + + Q+ + E LAQ + + E + +Q+ + ++L+ V
Sbjct: 404 ---QGLTDLQLQEAD--EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVA 458
Query: 1087 EQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL-KVQ 1145
D +L +LT + K+ + + +++ + L + +
Sbjct: 459 TSD----KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAE 514
Query: 1146 EEEEFIQERSVLQEQSAKLNTELQE------CYTKIIQLETLNTELTGHDVVNQEQINQL 1199
E E +Q ++L+++ + E+++ ++++++E LN + + +I +L
Sbjct: 515 AEIELLQ--NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMER----QRTEIARL 568
Query: 1200 KSKLEQLNTEN----DNLLSTVAELRSSIS 1225
++ L+ ++N +N+L +AELR +S
Sbjct: 569 QNVLDLTGSDNKGGFENVLEEIAELRREVS 598
Score = 72.5 bits (170), Expect = 1e-11
Identities = 153/797 (19%), Positives = 333/797 (41%), Gaps = 75/797 (9%)
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++++ L +R + + E E +EL LL+E ++L+ + ++ + +
Sbjct: 797 EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL---HRTVQ 853
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKR---ITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ + D + T+L ++E +LK I E + + K +L E + +
Sbjct: 854 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELR-EADRLLA 911
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
A + EK + +E T + L + +++ E L +E +NL D+ ++ Q
Sbjct: 912 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQ 970
Query: 998 TQSPDYT------EQYINEINKLNA--------LLKQKD---EEIIALNQKINNAQVS-- 1038
+ D E+ + EINK+ A L K+K+ EE+ L + I A+ +
Sbjct: 971 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1030
Query: 1039 -YMSMVSDYESKLAQFTTKLENMEEEM--QRVSKQLLDSK--QHNEELQILVREQDDQIK 1093
++ ++ + E L +LE ++ ++ Q+ +LD + EEL +L
Sbjct: 1031 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1090
Query: 1094 ELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEE 1149
+L+E E + + I + S +E +S ++ +K +++EEE
Sbjct: 1091 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1150
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q V+ Q +K TEL+ ++QLE N EL G + + +++++L+ Q+
Sbjct: 1151 NLQ---VVLRQMSKHKTELKNILD-MLQLE--NHELQGLKLQHDQRVSELEKT--QVAVL 1202
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA-DFQKTEHELRVQLSAFE--S 1266
+ L EL + + Q+G EI W++ L +R+ + ++ E R S E S
Sbjct: 1203 EEKL-----ELENLQQISQQQKG-EIE--WQKQLLERDKREIERMTAESRALQSCVECLS 1254
Query: 1267 KYEQLLDS---VQSSTQEETNKIVTMEQVTSL--QNKLQDKEEHLRNLQEKYADVINQIE 1321
K ++ L + +T +++ + S Q+ L+ E ++R LQ++ D +N+ +
Sbjct: 1255 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL-DQLNRDK 1313
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + ++ A +L Q + + +Q +L+ + L
Sbjct: 1314 L---SLHNDISAMQQQLQEKREAVNSLQEELANV-QDHLNLAKQDLLHTTKHQDVLLSEQ 1369
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
R D + + QL++ +EI E + L Q+ F+ ++++
Sbjct: 1370 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI----EENKLKLVQQEMMFQRLQKER 1425
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNVKITESV 1499
E ++E + + L ++ + + + + + + ERV+ ++E + ES
Sbjct: 1426 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE-EERWCES- 1483
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
L K +++ + L E + E L + E ++ + + L+N K +K V+
Sbjct: 1484 -LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 1542
Query: 1560 FASDTKQGRDEQLDNTM 1576
+ + + QL+ +
Sbjct: 1543 SLKEALKIQRSQLEKNL 1559
Score = 52.0 bits (119), Expect = 2e-05
Identities = 88/449 (19%), Positives = 192/449 (42%), Gaps = 43/449 (9%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKE---DIMNKLQNYIQENMD-LTDKLEKMSAEK 731
K+L + I++L K+ + +K ++ KE DIMNK ++ +D + ++ K E+
Sbjct: 8 KDLQIAIDSLD-SKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAK-ETEE 65
Query: 732 ISELLAKINHEEQSKIQT-QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
I +L ++ + + + + ++ I Y+ I+ + ++ ++ +L + +
Sbjct: 66 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQ 125
Query: 791 RRYSLERKADQLGSYLQE-----KQKAYSEYTIQEDELVNRLAV-----LMDHDRVVEKQ 840
R +E++ DQL + K+ A E +QE VN L ++ +E +
Sbjct: 126 RLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEAR 185
Query: 841 L----LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
L E +EL+K ++ E LQ L +Q + KA ++ E E++
Sbjct: 186 LNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENS-- 243
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
+L + LK + ++ L K++++D + N ++ +R ++V E +
Sbjct: 244 -----ELHAKLKHLQDDNNLL----KQQLKDFQNHLNHVVDGLVRPEEVAARVDE--LRR 292
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+L + + L ++ +L K E++ + K + E+ + E L
Sbjct: 293 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR--SKWERDEAQVRERKLQEEMALQQ 350
Query: 1017 -LLKQKDEEII-----ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
L EE AL ++N + + + + E+++ L++MEE Q
Sbjct: 351 EKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQ 410
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETK 1099
L ++ + E + +RE + + K+L++ K
Sbjct: 411 LQEADEEKERILAQLRELEKK-KKLEDAK 438
Score = 38.3 bits (85), Expect = 0.23
Identities = 97/558 (17%), Positives = 215/558 (38%), Gaps = 36/558 (6%)
Query: 182 KDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLK 241
K+Q ++ NK E+ K ++ E IA K + + ++
Sbjct: 34 KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVIS 93
Query: 242 DIES-----KDVRISSLEEANKLLEAARFEISLEH-SKLAQELEQXXXXXXXXXXXXXXL 295
++ K + E KL + E L+ +++ QE +Q L
Sbjct: 94 GLQEYLGTIKGQATQAQNECRKLRDEK--ETLLQRLTEVEQERDQLEIVAMDAENMRKEL 151
Query: 296 AKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHL-NCQIRQTNKELENKLATMGT 354
A+ +E + +E+ E+ +++ ++E +L + + Q +ELE
Sbjct: 152 AE--LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 209
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPW-SQLSSETLNQDTDKKINKNEIAKLEMV 413
E A+ + +K + G+ S+ K S+L ++ + D + K ++ +
Sbjct: 210 EQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNH 269
Query: 414 IQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTE 473
+ + LV E V + D ++ + + G SL +
Sbjct: 270 LNHVVDGLVRPEEVAARVDELRRKLKLGT-------GEMNIHSPSDVLGKSLADLQKQFS 322
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
++ +K + Q ++++ EKL + +E+ Q + A N K H
Sbjct: 323 EILARSKWERDEAQVRERKLQEEMALQQ-EKLATGQEEFRQACERALEARMNFDK--RQH 379
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+ +++QM+ I + S +EI LT+ ++ E +EEK + L + + +
Sbjct: 380 EARIQQMENEIHYLQENLKSMEEIQGLTD------LQLQEADEEKERILAQLRELEKKKK 433
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
+E ++ + + +LK ++ S K EL I + + + + I+Q +++
Sbjct: 434 LEDAKSQEQVFGLDKELKKLKK-AVATSDKL-ATAELTIAKDQLKSLHGTVMKINQERAE 491
Query: 654 QVC-SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
++ +E S + L+ ++ E+ L ++NL K + + LE +K + +
Sbjct: 492 ELQEAERFSRKAAQAARDLTRAEAEIEL-LQNLLRQKGEQF----RLEMEKTGVGTGANS 546
Query: 713 YIQENMDLTDKLEKMSAE 730
+ E L + +E+ E
Sbjct: 547 QVLEIEKLNETMERQRTE 564
Score = 35.1 bits (77), Expect = 2.1
Identities = 37/171 (21%), Positives = 79/171 (46%), Gaps = 15/171 (8%)
Query: 1410 ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
E+KD E Q T + E V L EY I+ + ++E LR
Sbjct: 65 EIKDLE-EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR------ 117
Query: 1470 ANHYETM-QKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
+ ET+ Q+ +E+E+ + ++L + ++ ++ K++AEL AL+E+ +E+ +L+
Sbjct: 118 -DEKETLLQRLTEVEQER--DQLEIVAMDAENMRKELAELESALQEQ----HEVNASLQQ 170
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ ++ E+ N+ A ++++++ + + Q L + KE
Sbjct: 171 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 221
>AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein.
Length = 2325
Score = 101 bits (241), Expect = 3e-20
Identities = 171/877 (19%), Positives = 379/877 (43%), Gaps = 86/877 (9%)
Query: 509 EEQITQLND---EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
E ++++L D + + + ++++ + K+M++ N + K + EELH
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
Query: 566 HLSQKVAELEEE-KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
QK + ++ GN++ M E ++ K + E++ + I +E
Sbjct: 1382 RTVQKRQQQKDFIDGNVE--------SLMTELEIEKSLKHHEDIVDE----IECIEKTLL 1429
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQV--CSEIKSVHLEEQIDALSASKKELALVI 682
EL + E E +L+ + + V ++ K L+ + DA ++ +
Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
Query: 683 ENLKLDKE--QLYGTIKDLENDK---EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+K D++ L KDLE K E+I+ ++ N I D + EK++E L
Sbjct: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEI-NKIVAAKDSDFQCLSKKKEKLTEELQ 1548
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K+ + + + + ++E ++ ++ +EL K KS++ ++ +AV+ DR+ ++
Sbjct: 1549 KLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL-DRQLGHKK 1607
Query: 798 KADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL---- 851
+ L GS +Q K + E E+ + +H R V+ L E+ + EL
Sbjct: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKC----NHIREVKSLLEELSFQKGELNVQI 1663
Query: 852 -QKKNQILL------EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
++K Q+ L +E +NLQ+ L M +H L N D+ + E+ + Q +
Sbjct: 1664 SERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL---KNILDMLQLENHELQGLKLQHD 1720
Query: 905 SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ + + Q ++++K E+E+L+ + + Q + I +K L E+ ++ IE +T A+
Sbjct: 1721 QRVSEL-EKTQVAVLEEKLELENLQ-QISQQQKGEIEWQKQLLERDKREIERMT---AES 1775
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ---TQSPDYTEQYINEINKLNALLKQK 1021
+ ++ +E L+ E+L + ++ +K + + + + + ++ + + KL +++
Sbjct: 1776 RALQSCVECLSKEKEDLQE-KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKL 1834
Query: 1022 DEEIIALNQ---KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
+E+ LN+ ++N + + + + +L N+++ + + LL + +H
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQ 1894
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
+ +L+ EQ K++ E FE + E + + N +
Sbjct: 1895 D---VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQ 1951
Query: 1139 XXXLKVQEEEEFIQERSV-LQEQSAKLNTELQECYTKIIQL--ETLNTELTGHDVVNQEQ 1195
+ + EE ++ V L+EQ +L EL + +K+ Q+ + L E + +E+
Sbjct: 1952 RLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEER 2011
Query: 1196 -INQLKSKLEQ----LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR---E 1247
L+ L Q L+ L+ EL + + D + + L Q L +R E
Sbjct: 2012 WCESLEKTLSQTKRQLSEREQQLVEKSGELLA-LQKEADSMRADFSLLRNQFLTERKKAE 2070
Query: 1248 ADFQKTEHELRVQLSAFESKY-EQLLDSVQSSTQEETNKIVT----------MEQVTSLQ 1296
+ L++Q S E EQ ++ + T ++V M+++ +Q
Sbjct: 2071 KQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQ 2130
Query: 1297 NKLQDKEEHLRN---LQEKYADVINQIEILRSEIEDE 1330
+ + ++ + N L+ + ++ + + L+SE++DE
Sbjct: 2131 YEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDE 2167
Score = 99.5 bits (237), Expect = 9e-20
Identities = 160/755 (21%), Positives = 342/755 (45%), Gaps = 90/755 (11%)
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
D ++D +K+ +A+ ++++L+DEI+ A + +++ + KQ+++ I K+S++
Sbjct: 436 DTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE----EFKQLEEAIQ-LKKISEAG 490
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD---SGRMIESDVYKKMIEMENLAET 611
K++ L ++L Q V +L +E +L+L + +G+ + ++ I +++L ++
Sbjct: 491 KDL--LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK--QKEIKDLQIAIDSL-DS 545
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI-SQLQSD-QVCSEIKSVHLEEQID 669
+ S +++QK Q+L I+ ++Y ++E +L +I S++ + + +++ E QI
Sbjct: 546 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIA 605
Query: 670 ALSASKKELALVIENL-------KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
A A KK+L VI L K Q + L ++KE ++ +L QE L
Sbjct: 606 ANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL-- 663
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
++ M AE + + LA++ +S +Q Q ++A +Q+ + +LS Y++ LE
Sbjct: 664 EIVAMDAENMRKELAEL----ESALQEQHEVNASLQQT-------QGDLSAYEAE---LE 709
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDELVNRLAVLMDHDRVVEKQL 841
+ + + L+ + +++ Q +Q A +E + L N L +
Sbjct: 710 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE------- 762
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
E E EN EL K + L ++N L+ L D Q H N +V+ R + + + + +L+
Sbjct: 763 -EKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
L + I L K + DL+ +F+ + + K+E++ V + +
Sbjct: 822 -LGTGEMNIHSPSDVL----GKSLADLQKQFS---------EILARSKWERDEAQVRERK 867
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
Q +E E L EE + ++ + + Q +Q NEI+ L LK
Sbjct: 868 LQ-EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM 926
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
EEI Q + + Q+ + E LAQ + + E + +Q+ + ++L
Sbjct: 927 -EEI----QGLTDLQLQEAD--EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKL 979
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V D +L +LT + K+ + + +++ +
Sbjct: 980 KKAVATSD----KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035
Query: 1142 L-KVQEEEEFIQERSVLQEQSAKLNTELQE------CYTKIIQLETLNTELTGHDVVNQE 1194
L + + E E +Q ++L+++ + E+++ ++++++E LN + +
Sbjct: 1036 LTRAEAEIELLQ--NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMER----QRT 1089
Query: 1195 QINQLKSKLEQLNTEN----DNLLSTVAELRSSIS 1225
+I +L++ L+ ++N +N+L +AELR +S
Sbjct: 1090 EIARLQNVLDLTGSDNKGGFENVLEEIAELRREVS 1124
Score = 97.9 bits (233), Expect = 3e-19
Identities = 166/860 (19%), Positives = 358/860 (41%), Gaps = 65/860 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
M L + E+ +L +++ ++ E I + L EE+ ++ + +++E N
Sbjct: 1308 MGVLHCNVPEHHNLENEVSRL--EDIMQHLKSKKREERWMRASKRQSEKEMEELH---HN 1362
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYS---LERKADQLGSYLQ-EKQKAYSEYTIQEDE 822
I+ L + KS C +EE ++ R+ ++ + L + L+ EK + E + E E
Sbjct: 1363 IDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIE 1422
Query: 823 LVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+ + + + R ++ L E E E ++K + +E+ + + SL + L
Sbjct: 1423 CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELER 1482
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
+A T + K QLR L+++ K + Q K + E++ E N + +
Sbjct: 1483 RAQETAV---NLVKADQQLRSLQADAKDLE--------QHKIKQEEILKEINKIVAAKDS 1531
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
D + L++K EK E + +L+ ++ + N ++ +++ L + + L K + ++ +S
Sbjct: 1532 DFQCLSKKKEKLTEELQKLQKDIEMAERNEDH---HLQVLKESEVLLQAKRAELEKLKSQ 1588
Query: 1002 DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME 1061
++Q E+ L+ L K EE+ L Q S + +D + L T++
Sbjct: 1589 VTSQQ--QEMAVLDRQLGHKKEELHLL-------QGSMVQAKADLQEALRLGETEVTEKC 1639
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
++ V L + EL + + E+ Q+ +K+ E N+ ++ +
Sbjct: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL-----QVVLRQMSKH 1694
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+ LK+Q ++ + + + Q A L +L+ + L+ +
Sbjct: 1695 KTELKNILDMLQLENHELQGLKLQHDQRVSE---LEKTQVAVLEEKLE-----LENLQQI 1746
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ + G ++ + + K ++E++ E+ L S V E S + ++ ++W++
Sbjct: 1747 SQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV-ECLSKEKEDLQEK----CDIWEK 1801
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
LAQ + E +++ S E + Q Q +K+ ++++Q +LQ+
Sbjct: 1802 KLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE 1861
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEI------EDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
K E + +LQE+ A+V + + + + ++ +D ++ D + E
Sbjct: 1862 KREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKE 1921
Query: 1356 NQSYKQMQEQSILNINEEN----AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
++ KQ Q Q + N EEN Q + ++ ++ + E HQLE
Sbjct: 1922 EET-KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE- 1979
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
K+ + + ++ +E Q+ + + +E + + +L+ ++ E +
Sbjct: 1980 KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 2039
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--EEEVAKTNEMQTALENQ 1529
+QKE++ R N +TE KQVA L +AL + + N ++ EN
Sbjct: 2040 ELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENS 2099
Query: 1530 EIEIVTLNDEITNLQNMVRA 1549
I+ E+ N RA
Sbjct: 2100 CIQKEMATIELVAQDNHERA 2119
Score = 80.6 bits (190), Expect = 4e-14
Identities = 201/1015 (19%), Positives = 415/1015 (40%), Gaps = 83/1015 (8%)
Query: 229 EAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
E W + K++ K++E I L + K LE E+ H + + +Q
Sbjct: 1341 EERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC---EVEELHRTVQKRQQQKDFIDGN 1397
Query: 288 XXXXXXXLA-KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
L ++S++ + EIE + +EL + LL ++ T ++ +
Sbjct: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
N + T++K ++ + + R++ + +K+ QL S L D K + +++
Sbjct: 1458 NAVEKF-TDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRS--LQADA-KDLEQHK 1512
Query: 407 IAKLEMVIQSLNKDLV--DKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM--EG 462
I K E +++ +NK + D ++ K KD +A+ +H + E
Sbjct: 1513 I-KQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1571
Query: 463 PSLIHV---------GTNTEDVNEIAKVQEQL---KQELND-EIKDVNVK-DLIEKLKSA 508
L+ T E+A + QL K+EL+ + V K DL E L+
Sbjct: 1572 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG 1631
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLK-QMQKTIDNFSKVSDS-NKEIVRLTEELHH 566
E ++T+ + I K++++ S K +L Q+ + + + KE L L
Sbjct: 1632 ETEVTEKCNHIREV-KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ 1690
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA--ETRLKAISLLE---S 621
+S+ EL+ LQL + G ++ D +E +A E +L+ +L +
Sbjct: 1691 MSKHKTELKNILDMLQLENHELQ-GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQ 1749
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID----ALSASKKE 677
QK ++ + +L++ E+E A+ LQS C + L+E+ D L+ +K+
Sbjct: 1750 QKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRV 1809
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
LA EN K+++ L + LE + + +L ++ + L + + M +++ E
Sbjct: 1810 LAAAEENSKMEQSNL----EKLELNVRKLQQELDQLNRDKLSLHNDISAMQ-QQLQEKRE 1864
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
+N ++ Q ++ + ++DL L K + L E + +D +
Sbjct: 1865 AVNSLQEELANVQDHLN--LAKQDL--------LHTTKHQDVLLSEQTRLQKD----ISE 1910
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
A++ +E++ + + ++E+ L+ + + ++ E E E +L+
Sbjct: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
Query: 858 LLEENQNLQISLSDMQQHYNALVEK---ANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
L E+ L+ L+D + + ++ K A E ++ L S KR E
Sbjct: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
Query: 915 QTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ +V+K E+ L+ E ++ + + ++ + L E+ +K + V L+ L+ ++ +E
Sbjct: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER-KKAEKQVASLKEALKIQRSQLEK 2089
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE--EIIALNQK 1031
N+ E + N I K + + + D E+ + +LN + + E + +A +
Sbjct: 2090 ---NLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKD 2145
Query: 1032 INNAQVSYMSMVSDYESKLA-QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ Q+ + +S++ + T L+N+ + + + L + NE L +
Sbjct: 2146 LERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL-------EG 2198
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LKE L F MN E + S + M D+ + LK Q
Sbjct: 2199 ELESLKE-NLPFTMNEGPFEEKLNFSQVHIM-DEHWRGEALREKLRHREDRLKAQLRHCM 2256
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ 1205
++ VL + + L ++ L L T T D + ++QL+S L +
Sbjct: 2257 SKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASSPSLSQLESSLTE 2310
Score = 79.8 bits (188), Expect = 7e-14
Identities = 139/695 (20%), Positives = 299/695 (43%), Gaps = 62/695 (8%)
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
++L D+ +LK E + + K++ +++E E + I+ +++KK L + E+ V
Sbjct: 1326 SRLEDIMQHLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLECEVEELHRTV 1384
Query: 958 TQLEAQLQEYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+ + Q N+E+L + +E+ K + +++D+ ++T + +E+ + +
Sbjct: 1385 QKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL-----KRRSELREAD 1439
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
LL + + E+ +K NA + +D + L Q + E +E Q + L+ +
Sbjct: 1440 RLLAEAESELSCTKEKTKNAVEKF----TDAKRSLLQTESDAEELERRAQETAVNLVKAD 1495
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMN----IPKTEGMIISSTIEPMSDDANNV--D 1129
Q LQ ++ + ++K+ ++ E+N ++ +S E ++++ + D
Sbjct: 1496 QQLRSLQADAKDLEQH--KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL--- 1185
++E E +Q +R+ L++ +++ ++ QE QL EL
Sbjct: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
G V + + + E TE N + V L +S + +I+E K L
Sbjct: 1614 QGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER-KTQLTL 1672
Query: 1246 READFQKTEHELRV---QLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNK--- 1298
+ + +K E L+V Q+S +++ + +LD +Q E + K+ ++V+ L+
Sbjct: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
Query: 1299 -LQDKEEHLRNLQEKYADVINQIEILRSEIEDEK------VAFXXXXXXXXXXXXXXXXD 1351
L++K E L NLQ+ +IE + +E +K A D
Sbjct: 1733 VLEEKLE-LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
Query: 1352 LRTENQSY--KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQ 1408
L+ + + K Q + +L EEN+++++S+ + ++ L L +
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
Query: 1409 LELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE---SELAILRLK 1465
+ ++ +K + +E NV+ L ++ + T ++ SE L+
Sbjct: 1852 ISAMQQQLQEKRE----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD 1907
Query: 1466 MHENANHYETMQKESEIERVKL------IEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
+ E AN +E QKE E ++ +L IEE +K+ + + ++ L K E E +K
Sbjct: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR---LQKERESEESKL 1964
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ L+ Q+ + L E+T+ ++ + SK+
Sbjct: 1965 ETSKVTLKEQQHQ---LEKELTDQKSKLDQVLSKV 1996
Score = 72.5 bits (170), Expect = 1e-11
Identities = 153/797 (19%), Positives = 333/797 (41%), Gaps = 75/797 (9%)
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++++ L +R + + E E +EL LL+E ++L+ + ++ + +
Sbjct: 1329 EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL---HRTVQ 1385
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKR---ITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ + D + T+L ++E +LK I E + + K +L E + +
Sbjct: 1386 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELR-EADRLLA 1443
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
A + EK + +E T + L + +++ E L +E +NL D+ ++ Q
Sbjct: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQ 1502
Query: 998 TQSPDYT------EQYINEINKLNA--------LLKQKD---EEIIALNQKINNAQVS-- 1038
+ D E+ + EINK+ A L K+K+ EE+ L + I A+ +
Sbjct: 1503 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED 1562
Query: 1039 -YMSMVSDYESKLAQFTTKLENMEEEM--QRVSKQLLDSK--QHNEELQILVREQDDQIK 1093
++ ++ + E L +LE ++ ++ Q+ +LD + EEL +L
Sbjct: 1563 HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
Query: 1094 ELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEE 1149
+L+E E + + I + S +E +S ++ +K +++EEE
Sbjct: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1682
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q V+ Q +K TEL+ ++QLE N EL G + + +++++L+ Q+
Sbjct: 1683 NLQ---VVLRQMSKHKTELKNILD-MLQLE--NHELQGLKLQHDQRVSELEKT--QVAVL 1734
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA-DFQKTEHELRVQLSAFE--S 1266
+ L EL + + Q+G EI W++ L +R+ + ++ E R S E S
Sbjct: 1735 EEKL-----ELENLQQISQQQKG-EIE--WQKQLLERDKREIERMTAESRALQSCVECLS 1786
Query: 1267 KYEQLLDS---VQSSTQEETNKIVTMEQVTSL--QNKLQDKEEHLRNLQEKYADVINQIE 1321
K ++ L + +T +++ + S Q+ L+ E ++R LQ++ D +N+ +
Sbjct: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQEL-DQLNRDK 1845
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+ + ++ A +L Q + + +Q +L+ + L
Sbjct: 1846 L---SLHNDISAMQQQLQEKREAVNSLQEELANV-QDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
R D + + QL++ +EI E + L Q+ F+ ++++
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI----EENKLKLVQQEMMFQRLQKER 1957
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNVKITESV 1499
E ++E + + L ++ + + + + + + ERV+ ++E + ES
Sbjct: 1958 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQE-EERWCES- 2015
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
L K +++ + L E + E L + E ++ + + L+N K +K V+
Sbjct: 2016 -LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
Query: 1560 FASDTKQGRDEQLDNTM 1576
+ + + QL+ +
Sbjct: 2075 SLKEALKIQRSQLEKNL 2091
Score = 55.2 bits (127), Expect = 2e-06
Identities = 90/494 (18%), Positives = 220/494 (44%), Gaps = 35/494 (7%)
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ SL ++++ L +K T+ +S+ T++ ++++ + K + E + +K+
Sbjct: 266 RFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEE----AMLQKQSC 321
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN--IENLNMNVEELNK 983
E+L+ + NT+ E + L +K E LE +L YK + E LN E +
Sbjct: 322 EELKSDLNTKNELLKQKTIELTRACQKQYE----LEQELAFYKIDAKFEPLNYYPSEYAE 377
Query: 984 MNLELIDK-HVQKQQTQSPDY-TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
++ + ++ K + + + TE YI + + + K + +E + + +
Sbjct: 378 IDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDT 437
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ--ILVREQDDQIKELKETK 1099
+ D E K++ T+L + +E+++ +Q+L + + ++L+ I +++ + K+L +
Sbjct: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
Query: 1100 LTFEM---NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQER 1154
L+ + N + E + + +E + L K + ++
Sbjct: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 557
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDNL 1213
S ++Q +N + Q+ +++ ++ + + T +EQ+ + + + E L + + +
Sbjct: 558 SGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 617
Query: 1214 LSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+S + E +I Q E +L K+ L QR + ++ +L + E+ ++L
Sbjct: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
Query: 1272 LDSVQSSTQEETNKIVTMEQV--------TSLQNKLQDKEEHLRNLQEKYADV--INQIE 1321
+ ++S+ QE+ +++Q L+ +L ++ L+E+ V + Q+E
Sbjct: 678 AE-LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLE 736
Query: 1322 --ILRSEIEDEKVA 1333
L++E+E E+ A
Sbjct: 737 QSALQAELEKERQA 750
Score = 35.9 bits (79), Expect = 1.2
Identities = 105/652 (16%), Positives = 260/652 (39%), Gaps = 41/652 (6%)
Query: 952 KNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
K +Y+ LE ++ E N NL +E+L+K+ L+L + ++ + + E N
Sbjct: 113 KKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKL-LKLRELNLSYNKISKIEGIENMCN- 170
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQV-----SYMSMVSDYES-KLAQFTTKLENMEEEM 1064
+ KLN + + + L +K+ + +V + +S + D K Q L +E +
Sbjct: 171 LQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPV 230
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN-IPKTEGMIISSTIEPMSD 1123
+ L + H L+ L Q ++ +E F + + + E + IE ++
Sbjct: 231 VTLPHYLQFTIFHLRSLESL-EGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIE--TE 287
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT 1183
+ + L +EE + ++ +E + LNT+ + K I+L
Sbjct: 288 ELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ 347
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNL--LSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ +++ + ++ +K E LN + + I + +R E +
Sbjct: 348 KQ--YELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYII 405
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
AQ +K E + +++ + LD+ +++ + T +++ L ++++
Sbjct: 406 DSAQA-VQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQT--RLSELHDEIEK 462
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
E+ + E++ + I++ + + + + L E Q KQ
Sbjct: 463 AEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQ 522
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
QE + ++ Q+ S + + L++ ++ + ++ +
Sbjct: 523 KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK---QYQQLESRLD 579
Query: 1422 EYTITLTQRNDEFENVRQQLVE--------YEKRIEDLTYEKESELAILRLKMHENANHY 1473
E + + +E +++ +QL E +K +E + + L ++ + + N
Sbjct: 580 EILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC 639
Query: 1474 ETMQKESE--IERVKLIEE----LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
++ E E ++R+ +E+ L + ++ ++ K++AEL AL+E+ +E+ +L+
Sbjct: 640 RKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ----HEVNASLQ 695
Query: 1528 NQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ ++ E+ N+ A ++++++ + + Q L + KE
Sbjct: 696 QTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
>AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated protein
CEP110 protein.
Length = 994
Score = 99 bits (238), Expect = 7e-20
Identities = 168/854 (19%), Positives = 369/854 (43%), Gaps = 83/854 (9%)
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE-KGNLQLHLVD 587
++++ + K+M++ N + K + EELH QK ++ GN++
Sbjct: 14 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQRQKDFIDGNVE----- 68
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
M E ++ K + E++ + I +E EL + E E +L+
Sbjct: 69 ---SLMTELEIEKSLKHHEDIVDE----IECIEKTLLKRRSELREADRLLAEAESELSCT 121
Query: 648 SQLQSDQV--CSEIKSVHLEEQIDALSASKKELALVIENLKLDKE--QLYGTIKDLENDK 703
+ + V ++ K L+ + DA ++ + +K D++ L KDLE K
Sbjct: 122 KEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHK 181
Query: 704 ---EDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
E+I+ ++ N I D + EK++E L K+ + + + + ++E
Sbjct: 182 IKQEEILKEI-NKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 240
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTI 818
++ ++ +EL K KS++ ++ +AV+ DR+ +++ L GS +Q K +
Sbjct: 241 EVLLQAKRAELEKLKSQVTSQQQEMAVL-DRQLGHKKEELHLLQGSMVQAKADLQEALRL 299
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKEL-----QKKNQILL------EENQNLQI 867
E E+ + +H R V+ L E+ + EL ++K Q+ L +E +NLQ+
Sbjct: 300 GETEVTEKC----NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQV 355
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
L M +H L N D+ + E+ + Q + + + + Q ++++K E+E+
Sbjct: 356 VLRQMSKHKTEL---QNILDMLQLENHELQGLKLQHDQRVSEL-EKTQVAVLEEKLELEN 411
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
L+ + + Q + I +K L E+ ++ IE +T A+ + ++ +E L+ E+L + +
Sbjct: 412 LQ-QISQQQKGEIEWQKQLLERDKREIERMT---AESRALQSCVECLSKEKEDLQE-KCD 466
Query: 988 LIDKHVQKQQ---TQSPDYTEQYINEINKLNALLKQKDEEIIALNQ---KINNAQVSYMS 1041
+ +K + + + + + ++ + + KL+ +++ +E+ LN+ ++N +
Sbjct: 467 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLDLNVRKLQQELDQLNRDKLSLHNDISAMQQ 526
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
+ + + +L N+++ + + LL + +H + +L+ EQ K++ E
Sbjct: 527 QLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQD---VLLSEQTRLQKDISEWANR 583
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV-LQEQ 1160
FE + E + + N + + + EE ++ V L+EQ
Sbjct: 584 FEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQ 643
Query: 1161 SAKLNTELQECYTKIIQL--ETLNTELTGHDVVNQEQ-INQLKSKLEQ----LNTENDNL 1213
+L EL + +K+ Q+ + L E + +E+ L+ L Q L+ L
Sbjct: 644 QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQL 703
Query: 1214 LSTVAELRSSISSAVDQRGFEIAELWKQHLAQR---EADFQKTEHELRVQLSAFESKY-E 1269
+ EL + + D + + L Q L +R E + L++Q S E E
Sbjct: 704 VEKSGELLA-LQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLE 762
Query: 1270 QLLDSVQSSTQEETNKIVT----------MEQVTSLQNKLQDKEEHLRN---LQEKYADV 1316
Q ++ + T ++V M+++ +Q + + ++ + N L+ + ++
Sbjct: 763 QKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEI 822
Query: 1317 INQIEILRSEIEDE 1330
+ + L+SE++DE
Sbjct: 823 SDAMRTLKSEVKDE 836
Score = 96.3 bits (229), Expect = 8e-19
Identities = 156/801 (19%), Positives = 332/801 (41%), Gaps = 60/801 (7%)
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYS---LERKADQLGSYLQ-EKQKAYSEYTIQED 821
NI+ L + KS C +EE ++ R+ ++ + L + L+ EK + E + E
Sbjct: 31 NIDDLLQEKKSLECEVEELHRTVQKRQRQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI 90
Query: 822 ELVNRLAVLMDHD-RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
E + + + + R ++ L E E E ++K + +E+ + + SL + L
Sbjct: 91 ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE 150
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAI 940
+A T + K QLR L+++ K + Q K + E++ E N + +
Sbjct: 151 RRAQETAV---NLVKADQQLRSLQADAKDLE--------QHKIKQEEILKEINKIVAAKD 199
Query: 941 RDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS 1000
D + L++K EK E + +L+ ++ + N ++ +++ L + + L K + ++ +S
Sbjct: 200 SDFQCLSKKKEKLTEELQKLQKDIEMAERNEDH---HLQVLKESEVLLQAKRAELEKLKS 256
Query: 1001 PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
++Q E+ L+ L K EE+ L Q S + +D + L T++
Sbjct: 257 QVTSQQ--QEMAVLDRQLGHKKEELHLL-------QGSMVQAKADLQEALRLGETEVTEK 307
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
++ V L + EL + + E+ Q+ +K+ E N+ ++ +
Sbjct: 308 CNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL-----QVVLRQMSK 362
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLET 1180
+ N+ LK+Q ++ + + + Q A L +L+ + L+
Sbjct: 363 HKTELQNILDMLQLENHELQGLKLQHDQRVSE---LEKTQVAVLEEKLE-----LENLQQ 414
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
++ + G ++ + + K ++E++ E+ L S V E S + ++ ++W+
Sbjct: 415 ISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCV-ECLSKEKEDLQEK----CDIWE 469
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQ 1300
+ LAQ + E +++ S E + Q Q +K+ ++++Q +LQ
Sbjct: 470 KKLAQTKRVLAAAEENSKMEQSNLEKLDLNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ 529
Query: 1301 DKEEHLRNLQEKYADVINQIEILRSEI------EDEKVAFXXXXXXXXXXXXXXXXDLRT 1354
+K E + +LQE+ A+V + + + + ++ +D ++ D +
Sbjct: 530 EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK 589
Query: 1355 ENQSYKQMQEQSILNINEEN----AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
E ++ KQ Q Q + N EEN Q + ++ ++ + E HQLE
Sbjct: 590 EEET-KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLE 648
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
K+ + + ++ +E Q+ + + +E + + +L+ ++ E +
Sbjct: 649 -KELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 707
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL--EEEVAKTNEMQTALEN 1528
+QKE++ R N +TE KQVA L +AL + + N ++ EN
Sbjct: 708 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 767
Query: 1529 QEIEIVTLNDEITNLQNMVRA 1549
I+ E+ N RA
Sbjct: 768 SCIQKEMATIELVAQDNHERA 788
Score = 79.0 bits (186), Expect = 1e-13
Identities = 200/1015 (19%), Positives = 414/1015 (40%), Gaps = 83/1015 (8%)
Query: 229 EAEW-KDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
E W + K++ K++E I L + K LE E+ H + + Q
Sbjct: 10 EERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC---EVEELHRTVQKRQRQKDFIDGN 66
Query: 288 XXXXXXXLA-KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE 346
L ++S++ + EIE + +EL + LL ++ T ++ +
Sbjct: 67 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 126
Query: 347 NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNE 406
N + T++K ++ + + R++ + +K+ QL S L D K + +++
Sbjct: 127 NAVEKF-TDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRS--LQADA-KDLEQHK 181
Query: 407 IAKLEMVIQSLNKDLV--DKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHM--EG 462
I K E +++ +NK + D ++ K KD +A+ +H + E
Sbjct: 182 I-KQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 240
Query: 463 PSLIHV---------GTNTEDVNEIAKVQEQL---KQELND-EIKDVNVK-DLIEKLKSA 508
L+ T E+A + QL K+EL+ + V K DL E L+
Sbjct: 241 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG 300
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLK-QMQKTIDNFSKVSDS-NKEIVRLTEELHH 566
E ++T+ + I K++++ S K +L Q+ + + + KE L L
Sbjct: 301 ETEVTEKCNHIREV-KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQ 359
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA--ETRLKAISLLE---S 621
+S+ EL+ LQL + G ++ D +E +A E +L+ +L +
Sbjct: 360 MSKHKTELQNILDMLQLENHELQ-GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQ 418
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID----ALSASKKE 677
QK ++ + +L++ E+E A+ LQS C + L+E+ D L+ +K+
Sbjct: 419 QKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRV 478
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
LA EN K+++ L + L+ + + +L ++ + L + + M +++ E
Sbjct: 479 LAAAEENSKMEQSNL----EKLDLNVRKLQQELDQLNRDKLSLHNDISAMQ-QQLQEKRE 533
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
+N ++ Q ++ + ++DL L K + L E + +D +
Sbjct: 534 AVNSLQEELANVQDHLN--LAKQDL--------LHTTKHQDVLLSEQTRLQKD----ISE 579
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
A++ +E++ + + ++E+ L+ + + ++ E E E +L+
Sbjct: 580 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 639
Query: 858 LLEENQNLQISLSDMQQHYNALVEK---ANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
L E+ L+ L+D + + ++ K A E ++ L S KR E
Sbjct: 640 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 699
Query: 915 QTLIVQKKKEIEDLEIEFNT-QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+ +V+K E+ L+ E ++ + + ++ + L E+ +K + V L+ L+ ++ +E
Sbjct: 700 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER-KKAEKQVASLKEALKIQRSQLEK 758
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE--EIIALNQK 1031
N+ E + N I K + + + D E+ + +LN + + E + +A +
Sbjct: 759 ---NLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKD 814
Query: 1032 INNAQVSYMSMVSDYESKLA-QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
+ Q+ + +S++ + T L+N+ + + + L + NE L +
Sbjct: 815 LERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL-------EG 867
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+++ LKE L F MN E + S + M D+ + LK Q
Sbjct: 868 ELESLKE-NLPFTMNEGPFEEKLNFSQVHIM-DEHWRGEALREKLRHREDRLKAQLRHCM 925
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQ 1205
++ VL + + L ++ L L T T D + ++QL+S L +
Sbjct: 926 SKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTS-TSADSASSPSLSQLESSLTE 979
Score = 75.4 bits (177), Expect = 2e-12
Identities = 137/687 (19%), Positives = 294/687 (42%), Gaps = 62/687 (9%)
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
+LK E + + K++ +++E E + I+ +++KK L + E+ V + + Q
Sbjct: 3 HLKSKKREERWMRASKRQSEKEME-ELHHNIDDLLQEKKSLECEVEELHRTVQKRQRQKD 61
Query: 966 EYKNNIENL--NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
N+E+L + +E+ K + +++D+ ++T + +E+ + + LL + +
Sbjct: 62 FIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL-----KRRSELREADRLLAEAES 116
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
E+ +K NA + +D + L Q + E +E Q + L+ + Q LQ
Sbjct: 117 ELSCTKEKTKNAVEKF----TDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 172
Query: 1084 LVREQDDQIKELKETKLTFEMN----IPKTEGMIISSTIEPMSDDANNV--DXXXXXXXX 1137
++ + ++K+ ++ E+N ++ +S E ++++ + D
Sbjct: 173 DAKDLEQH--KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 230
Query: 1138 XXXXLKVQEEEEFIQ-ERSVLQEQSAKLNTELQECYTKIIQLETLNTEL---TGHDVVNQ 1193
++E E +Q +R+ L++ +++ ++ QE QL EL G V +
Sbjct: 231 DHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK 290
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
+ + E TE N + V L +S + +I+E K L + + +K
Sbjct: 291 ADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER-KTQLTLIKQEIEKE 349
Query: 1254 EHELRV---QLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNK----LQDKEEH 1305
E L+V Q+S +++ + +LD +Q E + K+ ++V+ L+ L++K E
Sbjct: 350 EENLQVVLRQMSKHKTELQNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLE- 408
Query: 1306 LRNLQEKYADVINQIEILRSEIEDEK------VAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
L NLQ+ +IE + +E +K A DL+ + +
Sbjct: 409 LENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIW 468
Query: 1360 --KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQLELKDSEI 1416
K Q + +L EEN+++++S+ + ++ L L + + ++
Sbjct: 469 EKKLAQTKRVLAAAEENSKMEQSNLEKLDLNVRKLQQELDQLNRDKLSLHNDISAMQQQL 528
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE---SELAILRLKMHENANHY 1473
+K + +E NV+ L ++ + T ++ SE L+ + E AN +
Sbjct: 529 QEKRE----AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF 584
Query: 1474 ETMQKESEIERVKL------IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
E QKE E ++ +L IEE +K+ + + ++ L K E E +K + L+
Sbjct: 585 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR---LQKERESEESKLETSKVTLK 641
Query: 1528 NQEIEIVTLNDEITNLQNMVRASSSKI 1554
Q+ + L E+T+ ++ + SK+
Sbjct: 642 EQQHQ---LEKELTDQKSKLDQVLSKV 665
Score = 71.7 bits (168), Expect = 2e-11
Identities = 151/773 (19%), Positives = 324/773 (41%), Gaps = 75/773 (9%)
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
E E +EL LL+E ++L+ + ++ + + ++ + D + T+L ++E
Sbjct: 22 EKEMEELHHNIDDLLQEKKSLECEVEEL---HRTVQKRQRQKDFIDGNVESLMTEL-EIE 77
Query: 905 SNLKR---ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
+LK I E + + K +L E + + A + EK + +E T +
Sbjct: 78 KSLKHHEDIVDEIECIEKTLLKRRSELR-EADRLLAEAESELSCTKEKTKNAVEKFTDAK 136
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT------EQYINEINKLN 1015
L + +++ E L +E +NL D+ ++ Q + D E+ + EINK+
Sbjct: 137 RSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIV 195
Query: 1016 A--------LLKQKD---EEIIALNQKINNAQVS---YMSMVSDYESKLAQFTTKLENME 1061
A L K+K+ EE+ L + I A+ + ++ ++ + E L +LE ++
Sbjct: 196 AAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK 255
Query: 1062 EEM--QRVSKQLLDSK--QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI--IS 1115
++ Q+ +LD + EEL +L +L+E E + + I +
Sbjct: 256 SQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVK 315
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
S +E +S ++ +K +++EEE +Q V+ Q +K TELQ
Sbjct: 316 SLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ---VVLRQMSKHKTELQNILD 372
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
++QLE N EL G + + +++++L+ Q+ + L EL + + Q+G
Sbjct: 373 -MLQLE--NHELQGLKLQHDQRVSELEKT--QVAVLEEKL-----ELENLQQISQQQKG- 421
Query: 1234 EIAELWKQHLAQREA-DFQKTEHELRVQLSAFE--SKYEQLLDS---VQSSTQEETNKIV 1287
EI W++ L +R+ + ++ E R S E SK ++ L + +T +++
Sbjct: 422 EIE--WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVL 479
Query: 1288 TMEQVTSL--QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXX 1345
+ S Q+ L+ + ++R LQ++ D +N+ ++ + ++ A
Sbjct: 480 AAAEENSKMEQSNLEKLDLNVRKLQQEL-DQLNRDKL---SLHNDISAMQQQLQEKREAV 535
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+L Q + + +Q +L+ + L R D + +
Sbjct: 536 NSLQEELANV-QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETK 594
Query: 1406 THQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
QL++ +EI E + L Q+ F+ ++++ E ++E + + L +
Sbjct: 595 QQQLQVLQNEI----EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 650
Query: 1466 MHENANHYETMQKE--SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQ 1523
+ + + + + + + ERV+ ++E + ES L K +++ + L E + E
Sbjct: 651 LTDQKSKLDQVLSKVLAAEERVRTLQE-EERWCES--LEKTLSQTKRQLSEREQQLVEKS 707
Query: 1524 TALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTM 1576
L + E ++ + + L+N K +K V+ + + + QL+ +
Sbjct: 708 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNL 760
>BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase 1 protein.
Length = 1354
Score = 99.5 bits (237), Expect = 9e-20
Identities = 151/696 (21%), Positives = 299/696 (42%), Gaps = 63/696 (9%)
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+LK + QK + K+ KE+ + +L V+++E+EK LQ + +Y R
Sbjct: 444 QLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQ--RK 501
Query: 594 IESDVYKKMIEMENLAETRLKAISLLE--SQKFDLVQE-LHILQQKYDEVEDKLADISQL 650
E + K+ +EN T + L+ SQ L E L LQ++ +E D L S
Sbjct: 502 AEQENEKRR-NVENEVSTLKNQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDT 560
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK--LDKE--QLYGTI----KDLEND 702
S + Q+++L+ +E ++EN K DK+ QL + +D +D
Sbjct: 561 AVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHD 620
Query: 703 KE---DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E D+ ++ + +E L LEK+ E+ E +NH E+ K + ++ K++
Sbjct: 621 SEMIGDLQARITSLQEEVKHLKHNLEKVEGER-KEAQDMLNHSEKEKNNLEIDLNYKLKS 679
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
+ +E E++++K RL D+ S+E +A + + E +K E
Sbjct: 680 LQ---QRLEQEVNEHKVTKARL-------TDKHQSIE-EAKSVA--MCEMEKKLKEEREA 726
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
++ NR+ + +++ L + + + + L + + +E +NL + L + + + L
Sbjct: 727 REKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQL-EQESNKRLL 785
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
++ +T E+++ L+ LE +K+ E TL+ + K+ +E + Q
Sbjct: 786 LQNELKTQAFEADN------LKGLEKQMKQ---EINTLL-EAKRLLEFELAQLTKQYRGN 835
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ L ++ E +Y + L YK ++ L +EE N+ NL+ I + +++T
Sbjct: 836 EGQMRELQDQLEAE-QYFSTL------YKTQVKELKEEIEEKNRENLKKIQELQNEKETL 888
Query: 1000 SP--DYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ D E LL+++ E+ ++K + ++ S+L + + L
Sbjct: 889 ATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSML 948
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
E ++R +++L + + EE L +E+ E+ K FE NI TE + +
Sbjct: 949 TKDIEILRRENEELTERMKKAEEEYKLEKEE-----EISNLKAAFEKNI-NTERTLKTQA 1002
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEE------EFIQERSVLQEQSAKLNTELQEC 1171
+ +++ N D L+ +E+E E QER + K EL +
Sbjct: 1003 VNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDM 1062
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLN 1207
++++ EL + I QL++KL L+
Sbjct: 1063 QAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLS 1098
Score = 80.6 bits (190), Expect = 4e-14
Identities = 138/724 (19%), Positives = 308/724 (42%), Gaps = 54/724 (7%)
Query: 389 LSSETLNQD-TDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDT 447
LSS N + T +K+ L+ I L + L ++ + KD D
Sbjct: 406 LSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQL---KDEMEQKCRTSNIKLDK 462
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKS 507
++ +L E Q S + + + + + Q K E +E K NV++ + LK+
Sbjct: 463 IMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENE-KRRNVENEVSTLKN 521
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHL 567
E + +++ AN+ + +++ KQ+++ D SD+ VRL + +
Sbjct: 522 QLEDLKKVSQNSQLANEKLSQLQ-------KQLEEANDLLRTESDT---AVRLRKSHTEM 571
Query: 568 SQKVAELEEEKGNLQ-LHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLLESQK 623
S+ +++LE LQ + + +S + D Y+ +E R + I L+++
Sbjct: 572 SKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARI 631
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID-ALSASKKELALVI 682
L +E+ L+ ++VE + + + + SE + +LE ++ L + ++ L +
Sbjct: 632 TSLQEEVKHLKHNLEKVEGERKEAQDMLNH---SEKEKNNLEIDLNYKLKSLQQRLEQEV 688
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK--MSAEKISELLAKIN 740
K+ K +L + +E K M +++ ++E + +K E + EK +L
Sbjct: 689 NEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDL 748
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI---AVMEDRRYSLER 797
+ Q K++ G ++++ ++N+ +L + ++ L+ + A D LE+
Sbjct: 749 KQSQQKLEHLTGNKERMEDE---VKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEK 805
Query: 798 KADQ-LGSYLQEKQKAYSEYT-IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ Q + + L+ K+ E + + N + D++ +Q ++ + + K
Sbjct: 806 QMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKE 865
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
+I + +NL+ + ++Q L A + DLAE+++ Q LE +T E +
Sbjct: 866 EIEEKNRENLK-KIQELQNEKETL---ATQLDLAETKAESEQLARGLLEEQYFELTQESK 921
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
+ ++EI D + + E+ K + +N E +++ +EYK E
Sbjct: 922 KAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTERMKKAEEEYKLEKE--- 978
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI---IALNQKI 1032
EE++ + +K++ ++T +NKL ++ +KD +I A Q +
Sbjct: 979 ---EEISNLK-AAFEKNINTERTLK-------TQAVNKLAEIMNRKDFKIDRKKANTQDL 1027
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
+ + + + +F + ++E+ + QL++ H ELQ+ + ++ I
Sbjct: 1028 RKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDI 1087
Query: 1093 KELK 1096
++L+
Sbjct: 1088 EQLR 1091
Score = 79.8 bits (188), Expect = 7e-14
Identities = 128/680 (18%), Positives = 292/680 (42%), Gaps = 60/680 (8%)
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
L+++I +E++ ++ + D++ + + + DE N+ L +EK+
Sbjct: 428 LQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKE 487
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ ++H E Q+K + E+ +N++ +S ++ L + + + LA + ++ Q QL
Sbjct: 488 KMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQLANEKLSQLQKQL 547
Query: 901 RDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
+ L+ + L + K I LE N +++ R++ + N K + + +Y
Sbjct: 548 EEANDLLRTESDTAVRLRKSHTEMSKSISQLE-SLNRELQE--RNRILENSKSQTDKDYY 604
Query: 958 TQLEAQLQEYKNN-------IENLNMNVEELN------KMNLELIDKHVQKQQTQSPDYT 1004
QL+A L+ + + I +L + L K NLE ++ +K+ +++
Sbjct: 605 -QLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGE-RKEAQDMLNHS 662
Query: 1005 EQYINEIN-----KLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDYESKLAQ 1052
E+ N + KL +L ++ ++E+ L K + + + + + E KL +
Sbjct: 663 EKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKE 722
Query: 1053 FTTKLENMEEEMQRVSKQL----LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
E E + ++ KQ +D KQ ++L+ L ++ E+K LT ++
Sbjct: 723 EREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVK--NLTLQLEQES 780
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL----KVQEEE--EFIQERSVLQEQSA 1162
+ +++ + ++ + +A+N+ L ++ E E + ++ + Q
Sbjct: 781 NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR 840
Query: 1163 KLNTELQ-ECYTKII---QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
+L +L+ E Y + Q++ L E+ + N ++I +L+++ E L T+ D L T A
Sbjct: 841 ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD-LAETKA 899
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
E ++++ FE+ + K+ ++ + +H + +L S + ++ ++
Sbjct: 900 ESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVS-RLEEANSMLTKDIEILRRE 958
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+E T ++ E+ L +KEE + NL+ + IN L+++ ++
Sbjct: 959 NEELTERMKKAEEEYKL-----EKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRK 1013
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DLR + + +++Q L +N+E + + ++ +
Sbjct: 1014 DFKIDRKKANTQDLRKKEKENRKLQ----LELNQEREKFNQMVVKHQKELNDMQAQLVEE 1069
Query: 1399 EAKVLELTHQLELKDSEIYQ 1418
A EL QL K+S+I Q
Sbjct: 1070 CAHRNELQMQLASKESDIEQ 1089
Score = 74.9 bits (176), Expect = 2e-12
Identities = 129/626 (20%), Positives = 274/626 (43%), Gaps = 45/626 (7%)
Query: 297 KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHL-NCQIRQTNKELENKLATMGTE 355
++ E E++ +E + S + N E KK+ L N ++ Q K+LE + TE
Sbjct: 499 QRKAEQENEKRRNVENEVST-LKNQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTE 557
Query: 356 SKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQ 415
S K S + S+++S +L + K + +L+ +++
Sbjct: 558 SDTAVRLRK------SHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILE 611
Query: 416 SLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQ--QHMEGPSLIHVGTNTE 473
+ +D +I + + +++ E + Q M S
Sbjct: 612 AERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEI 671
Query: 474 DVN-EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
D+N ++ +Q++L+QE+N+ V L +K +S EE + E++ K+K
Sbjct: 672 DLNYKLKSLQQRLEQEVNEH--KVTKARLTDKHQSIEEAKSVAMCEMEK------KLKEE 723
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
+ + K + + + S + ++ + ++L HL+ +E+E NL L L + R
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
Query: 593 -MIESDVYKKMIEMENL--AETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADI- 647
++++++ + E +NL E ++K I+ L K L EL L ++Y E ++ ++
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
QL+++Q S + ++E + + +E I+ L+ +KE L T DL K +
Sbjct: 844 DQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETL-ATQLDLAETKAESE 902
Query: 708 NKLQNYIQEN-MDLTDKLEKMSAEKISELLAK---INHEEQSKIQTQFGIDAKIQERDLY 763
+ ++E +LT + +K ++ E+ K ++ E++ I+ +E +
Sbjct: 903 QLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEEL 962
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
E ++ +YK EE I+ + + + E+ + + + +E ++D
Sbjct: 963 TERMKKAEEEYK---LEKEEEIS---NLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFK 1016
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHE-NKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
++R R EK+ +++ E N+E +K NQ++++ Q L+DMQ LVE+
Sbjct: 1017 IDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKH----QKELNDMQAQ---LVEE 1069
Query: 883 -ANRTDLAESESTKYQTQLRDLESNL 907
A+R +L ++K ++ + L + L
Sbjct: 1070 CAHRNELQMQLASK-ESDIEQLRAKL 1094
Score = 56.8 bits (131), Expect = 6e-07
Identities = 90/478 (18%), Positives = 187/478 (39%), Gaps = 23/478 (4%)
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
++Q ++E Q+ + K+ EL E + LE+ +++ ++ Q +IN+ + K
Sbjct: 442 EMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRK 501
Query: 1203 LEQLNTENDNLLSTVAELRSSISSA--VDQRGFEIAELWKQHLAQREA--DFQKTEHELR 1258
EQ N + N+ + V+ L++ + V Q E Q Q E D +TE +
Sbjct: 502 AEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTA 561
Query: 1259 VQLSAFESKYEQLLDSVQSSTQE--ETNKIV------TMEQVTSLQNKLQDKEEHLRNLQ 1310
V+L ++ + + ++S +E E N+I+ T + LQ L+ + +
Sbjct: 562 VRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDS 621
Query: 1311 EKYADVINQIEILRSEIED-----EKV-AFXXXXXXXXXXXXXXXXDLRTE-NQSYKQMQ 1363
E D+ +I L+ E++ EKV +L + N K +Q
Sbjct: 622 EMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQ 681
Query: 1364 EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEY 1423
++ +NE + + + + E K+ E E ++ + Q +
Sbjct: 682 QRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQC 741
Query: 1424 T---ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
+ + L Q + E++ E +++LT + E E L +E
Sbjct: 742 SMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLK 801
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
+E+ ++ +E+N + L ++A+L K + E+Q LE ++ ++
Sbjct: 802 GLEK-QMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQV 860
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQ 1598
L+ + + + K + + K+ QLD K + + R L+ + L Q
Sbjct: 861 KELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQ 918
Score = 52.4 bits (120), Expect = 1e-05
Identities = 122/660 (18%), Positives = 257/660 (38%), Gaps = 46/660 (6%)
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q+ + ++ K + +K + + ++ +L E N NL V ++ K + L+ +
Sbjct: 438 QLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKM-LLQHRIN 496
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQ-KDEEIIALNQKINNAQVSYMSMVSDYESKLAQF 1053
+ Q ++ E+ N N+++ L Q +D + ++ N ++ N ++S + + +L +
Sbjct: 497 EYQRKAEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQLANEKLSQL------QKQLEEA 550
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
L + R+ K + + +L+ L RE ++ + L+ +K + + + + ++
Sbjct: 551 NDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAIL 610
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQE-----QSAKLNTE 1167
+ + D D ++ E ++ ER Q+ + K N E
Sbjct: 611 EAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLE 670
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNT---ENDNLLSTVAELRSSI 1224
+ Y + L E+ H V ++ +S E + E + L E R
Sbjct: 671 IDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKA 730
Query: 1225 SSAVDQRGFEIAEL---WKQ------HLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+ V Q + + L KQ HL + + L +QL +K L + +
Sbjct: 731 ENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNEL 790
Query: 1276 QSSTQEETN-KIVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEIEDEK 1331
++ E N K + + + L+ K E L L ++Y Q+ L+ ++E E+
Sbjct: 791 KTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQ 850
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTEN-QSYKQMQ-EQSILNINEENAQLKKSSXXXXXXXX 1389
F + EN + +++Q E+ L + A+ K S
Sbjct: 851 Y-FSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLL 909
Query: 1390 XXXXRVNDAEAKVLELTHQLELKDSE-IYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
E+K ++ E+ D + + E LT+ + ++L E K+
Sbjct: 910 EEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTERMKKA 969
Query: 1449 ED-LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKI----TESVSLNK 1503
E+ EKE E++ L+ +N N T++ ++ + +++ + KI + L K
Sbjct: 970 EEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRK 1029
Query: 1504 QVAE---LNKALEEEVAKTNEM----QTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+ E L L +E K N+M Q L + + ++V LQ + + S I++
Sbjct: 1030 KEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQ 1089
Score = 39.9 bits (89), Expect = 0.074
Identities = 44/252 (17%), Positives = 93/252 (36%), Gaps = 5/252 (1%)
Query: 94 LANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKE 153
L N LK + + +K ++ K+ T++ G+ ++E
Sbjct: 786 LQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGN----EGQMRE 841
Query: 154 KDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXED 213
+ L Q + +T + +L+E+I EK++ K + E
Sbjct: 842 LQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAES 901
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSK 273
+ ++E + + E K R ++I KD +S LEEAN +L + E+ +
Sbjct: 902 EQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEE 961
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN-MTELTKKIELLE 332
L + +++ K + E + + ++ + ++A M KI+ +
Sbjct: 962 LTERMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKK 1021
Query: 333 HLNCQIRQTNKE 344
+R+ KE
Sbjct: 1022 ANTQDLRKKEKE 1033
Score = 33.1 bits (72), Expect = 8.5
Identities = 20/74 (27%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQ----DKEEHLRNLQEKYADVIN 1318
+FE+++E++ D++ + E N ++ + +L L K +++ N +Y D IN
Sbjct: 6 SFETRFEKM-DNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTIN 64
Query: 1319 QIEILRSEIEDEKV 1332
+I LR + ED +V
Sbjct: 65 KIRDLRMKAEDYEV 78
>AY651261-1|AAX35689.1| 1244|Homo sapiens centrosomal protein 1
protein.
Length = 1244
Score = 99.5 bits (237), Expect = 9e-20
Identities = 160/755 (21%), Positives = 342/755 (45%), Gaps = 90/755 (11%)
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
D ++D +K+ +A+ ++++L+DEI+ A + +++ + KQ+++ I K+S++
Sbjct: 3 DTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE----EFKQLEEAIQ-LKKISEAG 57
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD---SGRMIESDVYKKMIEMENLAET 611
K++ L ++L Q V +L +E +L+L + +G+ + ++ I +++L ++
Sbjct: 58 KDL--LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK--QKEIKDLQIAIDSL-DS 112
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI-SQLQSD-QVCSEIKSVHLEEQID 669
+ S +++QK Q+L I+ ++Y ++E +L +I S++ + + +++ E QI
Sbjct: 113 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIA 172
Query: 670 ALSASKKELALVIENL-------KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
A A KK+L VI L K Q + L ++KE ++ +L QE L
Sbjct: 173 ANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL-- 230
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
++ M AE + + LA++ +S +Q Q ++A +Q+ + +LS Y++ LE
Sbjct: 231 EIVAMDAENMRKELAEL----ESALQEQHEVNASLQQT-------QGDLSAYEAE---LE 276
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDELVNRLAVLMDHDRVVEKQL 841
+ + + L+ + +++ Q +Q A +E + L N L +
Sbjct: 277 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE------- 329
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
E E EN EL K + L ++N L+ L D Q H N +V+ R + + + + +L+
Sbjct: 330 -EKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 388
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
L + I L K + DL+ +F+ + + K+E++ V + +
Sbjct: 389 -LGTGEMNIHSPSDVL----GKSLADLQKQFS---------EILARSKWERDEAQVRERK 434
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
Q +E E L EE + ++ + + Q +Q NEI+ L LK
Sbjct: 435 LQ-EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM 493
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
EEI Q + + Q+ + E LAQ + + E + +Q+ + ++L
Sbjct: 494 -EEI----QGLTDLQLQEAD--EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKL 546
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V D +L +LT + K+ + + +++ +
Sbjct: 547 KKAVATSD----KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 602
Query: 1142 L-KVQEEEEFIQERSVLQEQSAKLNTELQE------CYTKIIQLETLNTELTGHDVVNQE 1194
L + + E E +Q ++L+++ + E+++ ++++++E LN + +
Sbjct: 603 LTRAEAEIELLQ--NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMER----QRT 656
Query: 1195 QINQLKSKLEQLNTEN----DNLLSTVAELRSSIS 1225
+I +L++ L+ ++N +N+L +AELR +S
Sbjct: 657 EIARLQNVLDLTGSDNKGGFENVLEEIAELRREVS 691
Score = 56.0 bits (129), Expect = 1e-06
Identities = 56/313 (17%), Positives = 137/313 (43%), Gaps = 10/313 (3%)
Query: 404 KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGP 463
+NE+++LE ++Q L ++ ++ + K D L+ + + + E
Sbjct: 889 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 948
Query: 464 SLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAAN 523
+ +D I E L EL E + +D++++++ E+ + + E+ A+
Sbjct: 949 RTVQKRQQQKDF--IDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1006
Query: 524 KNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA----ELEEEKG 579
+ + + +S ++ + ++ F+ S + EEL +Q+ A + +++
Sbjct: 1007 RLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLR 1066
Query: 580 NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+LQ D + ++ + ++ K E+ + + L +K L +EL LQ+ +
Sbjct: 1067 SLQADAKDLEQHKIKQEEILK---EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM 1123
Query: 640 VE-DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
E ++ + L+ +V + K LE+ +++ ++E+A++ L KE+L+
Sbjct: 1124 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1183
Query: 699 LENDKEDIMNKLQ 711
+ K D+ L+
Sbjct: 1184 MVQAKADLQEALR 1196
Score = 44.8 bits (101), Expect = 0.003
Identities = 56/279 (20%), Positives = 124/279 (44%), Gaps = 24/279 (8%)
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++++ L +R + + E E +EL LL+E ++L+ + ++ + +
Sbjct: 896 EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL---HRTVQ 952
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKR---ITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ + D + T+L ++E +LK I E + + K +L E + +
Sbjct: 953 KRQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELR-EADRLLA 1010
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
A + EK + +E T + L + +++ E L +E +NL D+ ++ Q
Sbjct: 1011 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE-TAVNLVKADQQLRSLQ 1069
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ D EQ+ K K EEI+ KI A+ S +S + KL T +L
Sbjct: 1070 ADAKDL-EQH-----------KIKQEEILKEINKIVAAKDSDFQCLSKKKEKL---TEEL 1114
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ ++++++ + Q +E ++L++ + ++++LK
Sbjct: 1115 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK 1153
Score = 41.9 bits (94), Expect = 0.018
Identities = 49/206 (23%), Positives = 95/206 (46%), Gaps = 13/206 (6%)
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLK-LKQMQKT 543
L+ E + E + ++ L A++Q+ L + DA + K+K LK + ++
Sbjct: 1038 LQTESDAEELERRAQETAVNLVKADQQLRSL--QADAKDLEQHKIKQEEILKEINKIVAA 1095
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
D+ + KE +LTEEL L QK E+ E N HL ++ ++
Sbjct: 1096 KDSDFQCLSKKKE--KLTEELQKL-QKDIEMAER--NEDHHLQVLKESEVLLQAKRAELE 1150
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV---CSEIK 660
++++ ++ + +++L+ Q +ELH+LQ + + L + +L +V C+ I+
Sbjct: 1151 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR 1210
Query: 661 SVHLEEQIDALSASKKELALVIENLK 686
V + ++ LS K EL + I K
Sbjct: 1211 EV--KSLLEELSFQKGELNVQISERK 1234
Score = 39.5 bits (88), Expect = 0.098
Identities = 56/315 (17%), Positives = 142/315 (45%), Gaps = 23/315 (7%)
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ--ILVREQDDQIKELKET 1098
+ + D E K++ T+L + +E+++ +Q+L + + ++L+ I +++ + K+L
Sbjct: 4 TQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK 63
Query: 1099 KLTFEM---NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQE 1153
+L+ + N + E + + +E + L K + +
Sbjct: 64 QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 123
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDN 1212
+S ++Q +N + Q+ +++ ++ + + T +EQ+ + + + E L + +
Sbjct: 124 KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEG 183
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
++S + E +I Q E +L K+ L QR + ++ +L + E+ ++
Sbjct: 184 VISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKE 243
Query: 1271 LLDSVQSSTQEETNKIVTMEQV--------TSLQNKLQDKEEHLRNLQEKYADV--INQI 1320
L + ++S+ QE+ +++Q L+ +L ++ L+E+ V + Q+
Sbjct: 244 LAE-LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 302
Query: 1321 E--ILRSEIEDEKVA 1333
E L++E+E E+ A
Sbjct: 303 EQSALQAELEKERQA 317
Score = 35.5 bits (78), Expect = 1.6
Identities = 40/220 (18%), Positives = 92/220 (41%), Gaps = 9/220 (4%)
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
K+ Q++ ++ N E+ + + E +L+ +L D + +
Sbjct: 953 KRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1012
Query: 1420 THEYTITLTQRN---DEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETM 1476
E + T + ++F + ++ L++ E E+L + E A+ +K + +
Sbjct: 1013 ESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE-RRAQETAVNLVKADQQLRSLQAD 1071
Query: 1477 QKESEIERVK---LIEELNVKITESVSLNKQVAELNKALEEEVAK-TNEMQTALENQEIE 1532
K+ E ++K +++E+N + S + +++ + L EE+ K +++ A N++
Sbjct: 1072 AKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 1131
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
+ L + LQ RA K++ V+ D QL
Sbjct: 1132 LQVLKESEVLLQ-AKRAELEKLKSQVTSQQQEMAVLDRQL 1170
Score = 35.1 bits (77), Expect = 2.1
Identities = 37/171 (21%), Positives = 79/171 (46%), Gaps = 15/171 (8%)
Query: 1410 ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
E+KD E Q T + E V L EY I+ + ++E LR
Sbjct: 158 EIKDLE-EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR------ 210
Query: 1470 ANHYETM-QKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
+ ET+ Q+ +E+E+ + ++L + ++ ++ K++AEL AL+E+ +E+ +L+
Sbjct: 211 -DEKETLLQRLTEVEQER--DQLEIVAMDAENMRKELAELESALQEQ----HEVNASLQQ 263
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ ++ E+ N+ A ++++++ + + Q L + KE
Sbjct: 264 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 314
Score = 34.3 bits (75), Expect = 3.7
Identities = 65/313 (20%), Positives = 130/313 (41%), Gaps = 25/313 (7%)
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH-DVVNQ-EQINQLK 1200
+V+E +Q+R Q+Q ++ ++ T++ + L H D+V++ E I +
Sbjct: 943 EVEELHRTVQKR---QQQKDFIDGNVESLMTEL----EIEKSLKHHEDIVDEIECIEKTL 995
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
K E D LL+ AE S + + E K+ L Q E+D + E E R Q
Sbjct: 996 LKRRSELREADRLLAE-AESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE--ELERRAQ 1052
Query: 1261 LSAFE-SKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
+A K +Q L S+Q+ ++ E +KI E + + + K+ + L +K +
Sbjct: 1053 ETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTE 1112
Query: 1319 QIEILRSEIE----DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN----I 1370
+++ L+ +IE +E + ++Q Q QE ++L+
Sbjct: 1113 ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1172
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD--SEIYQKTHEYTITLT 1428
+E L + S R+ + E + H E+K E+ + E + ++
Sbjct: 1173 KKEELHLLQGSMVQAKADLQEALRLGETEV-TEKCNHIREVKSLLEELSFQKGELNVQIS 1231
Query: 1429 QRNDEFENVRQQL 1441
+R + ++Q++
Sbjct: 1232 ERKTQLTLIKQEI 1244
>AK128098-1|BAC87273.1| 1185|Homo sapiens protein ( Homo sapiens cDNA
FLJ46219 fis, clone TESTI4013742, moderately similar to
Mus musculus antigen identified by monoclonal antibody ).
Length = 1185
Score = 99.5 bits (237), Expect = 9e-20
Identities = 160/755 (21%), Positives = 342/755 (45%), Gaps = 90/755 (11%)
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
D ++D +K+ +A+ ++++L+DEI+ A + +++ + KQ+++ I K+S++
Sbjct: 269 DTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE----EFKQLEEAIQ-LKKISEAG 323
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD---SGRMIESDVYKKMIEMENLAET 611
K++ L ++L Q V +L +E +L+L + +G+ + ++ I +++L ++
Sbjct: 324 KDL--LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK--QKEIKDLQIAIDSL-DS 378
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI-SQLQSD-QVCSEIKSVHLEEQID 669
+ S +++QK Q+L I+ ++Y ++E +L +I S++ + + +++ E QI
Sbjct: 379 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIA 438
Query: 670 ALSASKKELALVIENL-------KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
A A KK+L VI L K Q + L ++KE ++ +L QE L
Sbjct: 439 ANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL-- 496
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
++ M AE + + LA++ +S +Q Q ++A +Q+ + +LS Y++ LE
Sbjct: 497 EIVAMDAENMRKELAEL----ESALQEQHEVNASLQQT-------QGDLSAYEAE---LE 542
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDELVNRLAVLMDHDRVVEKQL 841
+ + + L+ + +++ Q +Q A +E + L N L +
Sbjct: 543 ARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE------- 595
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
E E EN EL K + L ++N L+ L D Q H N +V+ R + + + + +L+
Sbjct: 596 -EKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 654
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
L + I L K + DL+ +F+ + + K+E++ V + +
Sbjct: 655 -LGTGEMNIHSPSDVL----GKSLADLQKQFS---------EILARSKWERDEAQVRERK 700
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
Q +E E L EE + ++ + + Q +Q NEI+ L LK
Sbjct: 701 LQ-EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM 759
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
EEI Q + + Q+ + E LAQ + + E + +Q+ + ++L
Sbjct: 760 -EEI----QGLTDLQLQEAD--EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKL 812
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V D +L +LT + K+ + + +++ +
Sbjct: 813 KKAVATSD----KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 868
Query: 1142 L-KVQEEEEFIQERSVLQEQSAKLNTELQE------CYTKIIQLETLNTELTGHDVVNQE 1194
L + + E E +Q ++L+++ + E+++ ++++++E LN + +
Sbjct: 869 LTRAEAEIELLQ--NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMER----QRT 922
Query: 1195 QINQLKSKLEQLNTEN----DNLLSTVAELRSSIS 1225
+I +L++ L+ ++N +N+L +AELR +S
Sbjct: 923 EIARLQNVLDLTGSDNKGGFENVLEEIAELRREVS 957
Score = 55.2 bits (127), Expect = 2e-06
Identities = 90/494 (18%), Positives = 220/494 (44%), Gaps = 35/494 (7%)
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ SL ++++ L +K T+ +S+ T++ ++++ + K + E + +K+
Sbjct: 99 RFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEE----AMLQKQSC 154
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN--IENLNMNVEELNK 983
E+L+ + NT+ E + L +K E LE +L YK + E LN E +
Sbjct: 155 EELKSDLNTKNELLKQKTIELTRACQKQYE----LEQELAFYKIDAKFEPLNYYPSEYAE 210
Query: 984 MNLELIDK-HVQKQQTQSPDY-TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
++ + ++ K + + + TE YI + + + K + +E + + +
Sbjct: 211 IDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDT 270
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ--ILVREQDDQIKELKETK 1099
+ D E K++ T+L + +E+++ +Q+L + + ++L+ I +++ + K+L +
Sbjct: 271 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 330
Query: 1100 LTFEM---NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQER 1154
L+ + N + E + + +E + L K + ++
Sbjct: 331 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 390
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK-SKLEQLNTENDNL 1213
S ++Q +N + Q+ +++ ++ + + T +EQ+ + + + E L + + +
Sbjct: 391 SGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 450
Query: 1214 LSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+S + E +I Q E +L K+ L QR + ++ +L + E+ ++L
Sbjct: 451 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 510
Query: 1272 LDSVQSSTQEETNKIVTMEQV--------TSLQNKLQDKEEHLRNLQEKYADV--INQIE 1321
+ ++S+ QE+ +++Q L+ +L ++ L+E+ V + Q+E
Sbjct: 511 AE-LESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLE 569
Query: 1322 --ILRSEIEDEKVA 1333
L++E+E E+ A
Sbjct: 570 QSALQAELEKERQA 583
Score = 35.1 bits (77), Expect = 2.1
Identities = 37/171 (21%), Positives = 79/171 (46%), Gaps = 15/171 (8%)
Query: 1410 ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
E+KD E Q T + E V L EY I+ + ++E LR
Sbjct: 424 EIKDLE-EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR------ 476
Query: 1470 ANHYETM-QKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
+ ET+ Q+ +E+E+ + ++L + ++ ++ K++AEL AL+E+ +E+ +L+
Sbjct: 477 -DEKETLLQRLTEVEQER--DQLEIVAMDAENMRKELAELESALQEQ----HEVNASLQQ 529
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ ++ E+ N+ A ++++++ + + Q L + KE
Sbjct: 530 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKE 580
>X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal mRNA
for myosin heavy chain light meromyosin region. ).
Length = 876
Score = 99.1 bits (236), Expect = 1e-19
Identities = 174/884 (19%), Positives = 351/884 (39%), Gaps = 64/884 (7%)
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
KL + SA I +++ + + K G+ +KI++ ++ ++ + ++RI LE
Sbjct: 1 KLAQESAMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE 60
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQE----KQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E I R E+ L L+E ++A + Q + R A R +E
Sbjct: 61 EEIEAERTSRAKAEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKREAEFQKMRRDLE 120
Query: 839 KQLLEIEHENKELQKKN---------QI--LLEENQNLQISLSDMQQHYNALVEKANRTD 887
+ L+ E L+KK+ QI L Q L+ S+M+ + L
Sbjct: 121 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 180
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKK 944
A+ K L D S +K E Q LI ++ ++ ++E++ Q++ +
Sbjct: 181 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEYSRQLDEKDTLET 240
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
L+ + + + +L+ QL+E + ++ + + ++ + +L+ + +++Q +
Sbjct: 241 QLSRGKQAFTQQIEELKRQLEE-EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL- 298
Query: 1005 EQYINEINKLNALLKQKDE-EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
++ +++ N A + K E + I +++ A+ + D E + K ++E+
Sbjct: 299 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKT 358
Query: 1064 MQRVSKQ----LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE 1119
QR+ + ++D ++ N L ++Q + K L E K E E S
Sbjct: 359 KQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKILAEWKQKCEETHAVLESFQKES--R 416
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLE 1179
+S + + LK +E + QE S L EQ A+ + E Q+E
Sbjct: 417 SLSTELFKIKNAYEESLDQLETLK-RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 475
Query: 1180 TLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELW 1239
+EL Q + + ++ LE + + V +++S + + ++ EI ++
Sbjct: 476 QEKSEL-------QAALEEAEASLEHEEGKILRIQLEVNQVKSEVDRKIAEKDEEIDQMK 528
Query: 1240 KQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK- 1298
+ H+ E+ E+R + A K + D + Q + E + + QN
Sbjct: 529 RNHIRIEESMQSTLNAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEDLRNYQNTQ 588
Query: 1299 --LQDKEEHL-------RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXX----- 1344
L+D + HL +L+E+ A V + +L++EIE+ +
Sbjct: 589 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL 648
Query: 1345 -XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
L T+N S +++ +I++ +++ + DA
Sbjct: 649 DASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIKEARNAEEKAKKAITDAAMMAE 708
Query: 1404 ELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV-----RQQLVEYEKRIEDLTYEKE 1456
EL + + E +K E T+ L R DE E + ++Q+ + E ++ +L E E
Sbjct: 709 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAKVRELEGEVE 768
Query: 1457 SEL-----AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV-SLNKQVAELNK 1510
SE A+ L HE T Q E + + + +++L K+ V S +Q E +
Sbjct: 769 SEQKRNVEAVKGLHKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 828
Query: 1511 ALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
++K +Q LE E ++ L+ R +KI
Sbjct: 829 QSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 872
Score = 95.5 bits (227), Expect = 1e-18
Identities = 162/876 (18%), Positives = 375/876 (42%), Gaps = 65/876 (7%)
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
LA++S +K +++EK + M+ L KIE + L Q+++ KEL+ ++ +
Sbjct: 2 LAQESAMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 61
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
E +A + K L S + + +++ +L T ++NK A+ + +
Sbjct: 62 EIEAERTSRAKAEKLRS-----DLSRELEEISERLEEAVGATSTQIEMNKKREAEFQKMR 116
Query: 415 QSLNKDLVDKEYVISE-KDTXXXXXXXXXXGKDTLIAQLQ-LEHQQHMEGPSLIHVGTNT 472
+ L + + E + + D L Q LE ++ + + +N
Sbjct: 117 RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 176
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKD-----LIEKLKSAEEQITQLN-------DEID 520
E V++ E++ + L D++ ++ K+ LI L + ++ Q DE D
Sbjct: 177 ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEYSRQLDEKD 236
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE-ELHHLSQKVAELEEEKG 579
+ + K +++++++ ++ K + ++ + + L ++ E +E K
Sbjct: 237 TLETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 296
Query: 580 NLQLHLVDYDSG-----RMIESDVYKKMIEMEN----LAETRLKAISLLESQKFDLVQEL 630
LQ + +S E+D ++ E+E LA+ A +E+
Sbjct: 297 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE 356
Query: 631 HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
Q+ +EVED + D+ + + + K + ++ + +E V+E+ + +
Sbjct: 357 KTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKILAEWKQKCEETHAVLESFQKESR 416
Query: 691 QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE------LLAKINHE-E 743
L + ++N E+ +++L+ +EN +L ++ ++ E+I+E L KI + E
Sbjct: 417 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT-EQIAEGGKRIHELEKIKKQVE 475
Query: 744 QSKIQTQFGI---DAKIQERDLYIENIESELSKYKS----RICRLEESIAVMEDRRYSLE 796
Q K + Q + +A ++ + I I+ E+++ KS +I +E I M+ +E
Sbjct: 476 QEKSELQAALEEAEASLEHEEGKILRIQLEVNQVKSEVDRKIAEKDEEIDQMKRNHIRIE 535
Query: 797 RKADQ-LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
L + ++ + A E +L N + + ++H + + L + + K
Sbjct: 536 ESMQSTLNAEIRSRNDAIRLKKKMEGDL-NEMEIQLNHANRMAAEDLRNYQNTQAILKDT 594
Query: 856 QILLEE----NQNLQISLSDMQQHYNALVEKAN--RTDLAESESTKYQTQLRDLESNLK- 908
Q+ L++ ++L+ L+ +++ N L + R L ++E ++ + L+++ +
Sbjct: 595 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 654
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
++ H T ++ KK++E + ++E I++ + EK +K I + +L++ +
Sbjct: 655 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIKEARNAEEKAKKAITDAAMMAEELKKEQ 714
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQKDEEIIA 1027
+ +L E K NLE K +Q + ++ + +I KL A +++ + E+ +
Sbjct: 715 DTSAHL-----ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAKVRELEGEVES 769
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL--LDSKQHNEELQILV 1085
QK N V + + +E K+ + T + E + + R+ + L +K + + Q
Sbjct: 770 -EQKRN---VEAVKGLHKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 825
Query: 1086 REQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPM 1121
E+ + K ++ E+ + I S + +
Sbjct: 826 AEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL 861
Score = 81.8 bits (193), Expect = 2e-14
Identities = 180/921 (19%), Positives = 377/921 (40%), Gaps = 95/921 (10%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D L +K+K+ +S LQ K++ + + LQ+KI E IE +
Sbjct: 13 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERTSRAK 72
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+ ++ +++E A + + K+R + E + +R LEEA EA
Sbjct: 73 AEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKR---EAEFQKMR-RDLEEATLQHEA 128
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIE-PSCEEKTEIEEKGS-LEIAN 320
+ +H+ EL + KQ +E E K EI++ S +E +
Sbjct: 129 TAATLRKKHADSVAELGEQIDNLQR--------VKQKLEKEKSEMKMEIDDLASNMETVS 180
Query: 321 MTE--LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
+ L K LE +I+ +E + + + + + + S + K T
Sbjct: 181 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEYSRQLDEKDTLET 240
Query: 379 -ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
S+ K ++Q E L + +++I + + DL+ ++Y E+
Sbjct: 241 QLSRGKQAFTQ-QIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY--EEEQEAKAE 297
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
++ +AQ + +++ TE++ E K Q Q+ + ++ VN
Sbjct: 298 LQRAMSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 349
Query: 498 VK-DLIEKLKS-AEEQITQLNDEIDAAN----------KNMIKVKSNHKLKLKQMQKTID 545
K +EK K + ++ L +++ N N K+ + K K ++ ++
Sbjct: 350 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKILAEWKQKCEETHAVLE 409
Query: 546 NFSKVSDS-NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
+F K S S + E+ ++ ++ L+ E NLQ + D + ++ E K++ E
Sbjct: 410 SFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL-TEQIAEGG--KRIHE 466
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI--KSV 662
+E + + +E +K +L L + + E K+ I QL+ +QV SE+ K
Sbjct: 467 LEKIKKQ-------VEQEKSELQAALEEAEASLEHEEGKILRI-QLEVNQVKSEVDRKIA 518
Query: 663 HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
+E+ID + K+ + E++ + L I+ ND + K++ + E +
Sbjct: 519 EKDEEIDQM---KRNHIRIEESM---QSTLNAEIRS-RNDAIRLKKKMEGDLNEMEIQLN 571
Query: 723 KLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
+M+AE L + + TQ +D ++ + E+++ +L+ + R L+
Sbjct: 572 HANRMAAED----LRNYQNTQAILKDTQLHLDDALRSQ----EDLKEQLAMVERRANLLQ 623
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
I + ER L + + Q L+N L ++ ++
Sbjct: 624 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 683
Query: 843 EI--EHENKELQKKNQIL--------LEENQNLQISLSDMQQHYNALV-EKANRTDLAES 891
+I E N E + K I L++ Q+ L M+++ V + +R D AE
Sbjct: 684 DIIKEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 743
Query: 892 ESTK-YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ K + Q++ LE+ ++ + E ++ ++K+ +E ++ + E +++ E+
Sbjct: 744 LALKGGKKQIQKLEAKVRELEGEVES---EQKRNVE--AVKGLHKHERKVKELTYQTEED 798
Query: 951 EKNI----EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
KNI + V +L+A+++ YK E EE + +NL + +Q + ++ + +
Sbjct: 799 RKNILRLQDLVDKLQAKVKSYKRQAE----EAEEQSNVNLSKF-RRIQHELEEAEERADI 853
Query: 1007 YINEINKLNALLKQKDEEIIA 1027
+++NKL ++ +II+
Sbjct: 854 AESQVNKLRVKSREVHTKIIS 874
Score = 72.9 bits (171), Expect = 9e-12
Identities = 112/536 (20%), Positives = 227/536 (42%), Gaps = 47/536 (8%)
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
D E+ Q KL+ E EM + ++ D + +LQ ++E +I+EL+E
Sbjct: 9 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERT 68
Query: 1105 NIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA 1162
+ K E + +S +E +S+ + + E EF + R L+E A
Sbjct: 69 SRAKAEKLRSDLSRELEEISERLEEA----VGATSTQIEMNKKREAEFQKMRRDLEE--A 122
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLS---TVA 1218
L E + +++ EL G + N +++ Q L+ + ++ E D+L S TV+
Sbjct: 123 TLQHEATAATLRKKHADSV-AEL-GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 180
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQS- 1277
+ + ++ +++E+ + Q+ T R+Q + E Y + LD +
Sbjct: 181 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVE--YSRQLDEKDTL 238
Query: 1278 STQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXX 1337
TQ K +Q+ L+ +L+++ + L + ++LR + E+E+ A
Sbjct: 239 ETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEA---- 294
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
+E ++ E + EE + KK VN
Sbjct: 295 ----KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN- 349
Query: 1398 AEAKVLELTHQL---ELKDSEI-YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL-- 1451
A+ LE T Q E++D I ++T+ L ++ F+ + L E++++ E+
Sbjct: 350 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKI---LAEWKQKCEETHA 406
Query: 1452 ---TYEKES-----ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNK 1503
+++KES EL ++ E+ + ET+++E++ + + I +L +I E K
Sbjct: 407 VLESFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQE-ISDLTEQIAEG---GK 462
Query: 1504 QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
++ EL K ++ + +E+Q ALE E + +I +Q V S++ + ++
Sbjct: 463 RIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEVNQVKSEVDRKIA 518
>AB046785-1|BAB13391.2| 1313|Homo sapiens KIAA1565 protein protein.
Length = 1313
Score = 99.1 bits (236), Expect = 1e-19
Identities = 179/906 (19%), Positives = 374/906 (41%), Gaps = 72/906 (7%)
Query: 663 HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD----LENDKEDIMNKLQNYIQENM 718
HL E++D + K++L ++ + K + + D +E E + KL +E +
Sbjct: 409 HLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERI 468
Query: 719 DLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
+ E+I + K E + +I+ + I++R + E S+ ++ +
Sbjct: 469 AALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR---LALSLKENSRLENEL 525
Query: 779 CRLEESIAVMEDRRYSLERKADQ-LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
E +A E+ L+R + L + + +E+ +QE+ L RV+
Sbjct: 526 LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL 585
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
+ Q+ E++ E +E + + ++L +N S S+ + + +E + L E
Sbjct: 586 QDQVDELQSELEEYRAQGRVLRLPLKN---SPSEEVEANSGGIEPEH--GLGSEECNPLN 640
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
+ + E ++++ +H I + E+ED + Q++ + K E ++ E
Sbjct: 641 MSI-EAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENE 699
Query: 958 TQ-LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
T LE Q+ + KN I L L + + E +H ++++ E+ + KL
Sbjct: 700 THTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRL 759
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS-- 1074
Q + E+ A ++ AQ S+ +S A K+ + +E+++ ++ L S
Sbjct: 760 ---QHEMELKA---RLTQAQASFEREREGLQSS-AWTEEKVRGLTQELEQFHQEQLTSLV 812
Query: 1075 KQHNEELQILVREQ-DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
++H E + L +E + +EL+E + +E + E I+ + I ++++ + +
Sbjct: 813 EKHTLEKEELRKELLEKHQRELQEGR--YESEKLQQENSILRNEITTLNEEDSISNLKLG 870
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
++Q+ E QE + +Q+ L ++ E K QL+ NTEL+ + NQ
Sbjct: 871 TLNGSQE--EMQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQ 928
Query: 1194 EQINQL----------------KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
E++ +L S LE+ E NL + + S+ V E++E
Sbjct: 929 EKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSE 988
Query: 1238 LWKQ-HLAQREADFQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE-ETNKIVTMEQVT 1293
+ Q H+ Q+E K E E QL S ++Q + SV S ++ K E++
Sbjct: 989 VKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN 1048
Query: 1294 SLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEI--EDEKVA-FXXXXXXXXXXXXX 1347
S +KL E + ++++ +Q L+S++ EKV
Sbjct: 1049 SCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR 1108
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
DLR Q K+ +Q +++++++ S +L H
Sbjct: 1109 MKSDLRVTQQE-KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH 1167
Query: 1408 QLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
+ + ++Q+ +E T+ Q N + +L +++ L ES L L H
Sbjct: 1168 LMNEEQQLLWQE-NERLQTMVQ------NTKAELTHSREKVRQL----ESNL----LPKH 1212
Query: 1468 ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
+ + +E E++ L E + E N++V+++N +LE+E+ + L+
Sbjct: 1213 QKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQELETIHLENEGLK 1271
Query: 1528 NQEIEI 1533
+++++
Sbjct: 1272 KKQVKL 1277
Score = 73.3 bits (172), Expect = 6e-12
Identities = 133/683 (19%), Positives = 308/683 (45%), Gaps = 71/683 (10%)
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
H + + K+ E+ K+ + +K+ K+ + L+ A +Q +L EI+ A
Sbjct: 446 HAAIERRNEYNLRKLDEEYKERIA-ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEE 504
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH-----LSQKVAELE------ 575
++ L LK+ + + + ++ E LT +L L++K +L+
Sbjct: 505 NYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 564
Query: 576 --EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL-AETRLKAISLLESQKFDLVQELHI 632
+E+ Q+ R+++ V + E+E A+ R+ + L S ++
Sbjct: 565 FLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGG 624
Query: 633 LQQKYDEVEDKLADIS-QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
++ ++ ++ ++ ++++ V ++K H I L ++ E +LD E
Sbjct: 625 IEPEHGLGSEECNPLNMSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEK-QLD-ET 681
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ- 750
+ K EN K+ N+ ++ DL +++ ++ + + +L + +HE + + +
Sbjct: 682 VVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQ--AAVLKEAHHEATCRHEEEK 739
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA---DQLGSYLQ 807
+ K++E +++ + L RL ++ A E R L+ A +++ Q
Sbjct: 740 KQLQVKLEEEKTHLQE-KLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQ 798
Query: 808 EKQKAYSE--------YTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
E ++ + E +T++++EL R +L H R +L E +E+++LQ++N IL
Sbjct: 799 ELEQFHQEQLTSLVEKHTLEKEEL--RKELLEKHQR----ELQEGRYESEKLQQENSILR 852
Query: 860 EE--NQNLQISLSDMQ-QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
E N + S+S+++ N E+ +T+ + E+ Q + +L+ + + ++Q
Sbjct: 853 NEITTLNEEDSISNLKLGTLNGSQEEMQKTETVKQENAAVQKMVENLKKQISELKIKNQQ 912
Query: 917 L------IVQKKKEIEDLEIEFNTQIESAI--RDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
L + QK + ++ E N ++ + ++K+ N E+ + L+ +L+ K
Sbjct: 913 LDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCK 972
Query: 969 NNIENLNMNVE-ELNKMNLEL----IDKHV-------QKQQTQSPDYT--EQYINEINKL 1014
L ++E EL+++ ++ + H+ KQ + PD + +Q I+ +
Sbjct: 973 VQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSY 1032
Query: 1015 N-ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
N LLK+K+ AL++++N+ V ++ S E ++A + ++ E + + QL+
Sbjct: 1033 NEKLLKEKE----ALSEELNSC-VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVA 1087
Query: 1074 SKQHNEELQILVREQDDQIKELK 1096
S++ + L+ V+ + Q+ +K
Sbjct: 1088 SQEKVQNLEDTVQNVNLQMSRMK 1110
Score = 66.1 bits (154), Expect = 1e-09
Identities = 104/479 (21%), Positives = 222/479 (46%), Gaps = 52/479 (10%)
Query: 483 EQLKQE---LNDEIKDVNVKDLIEKLK------SAEE-QITQLNDEIDAANKNMIK--VK 530
E+L+QE L +EI +N +D I LK S EE Q T+ + +AA + M++ K
Sbjct: 842 EKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMQKTETVKQENAAVQKMVENLKK 901
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH-HLSQKVAELEEEKGNLQLHLVDYD 589
+LK+K Q ++N +++S N + +EL+ L++ + + E+E GN L + +
Sbjct: 902 QISELKIKNQQLDLEN-TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQE 960
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQ 649
+ E E+E +S LE++ ++ + HI+QQ+ ++D+L + Q
Sbjct: 961 KFNLKE--------ELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1012
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK 709
L C ++ +++I ++ + ++L E L E+L + DK +
Sbjct: 1013 LHR---CPDLSD--FQQKISSVLSYNEKLLKEKEAL---SEELNSCV-----DKLAKSSL 1059
Query: 710 LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
L++ I E SA S+L+A + Q+ T ++ ++ + +
Sbjct: 1060 LEHRIATMKQEQKSWEHQSASLKSQLVAS-QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ 1118
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
E K + L + + + ++ E G + Q+K+ ++ + D L+N
Sbjct: 1119 EKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKL----DHLMNEEQQ 1174
Query: 830 LM--DHDR---VVEKQLLEIEHENKELQKKNQILLEENQ---NLQISLSDMQQHYNALVE 881
L+ +++R +V+ E+ H +++++ LL ++Q N +++ +Q +L
Sbjct: 1175 LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKR 1234
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE-DLEIEFNTQIESA 939
+ ++ +S + + +Q+ LE L+ I E++ L KKK+++ D ++ N+ + S+
Sbjct: 1235 ECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL---KKKQVKLDEQLMENSVVGSS 1290
Score = 65.3 bits (152), Expect = 2e-09
Identities = 151/766 (19%), Positives = 296/766 (38%), Gaps = 49/766 (6%)
Query: 222 QENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQX 281
Q + +AE + +R+ + + K+ S L++A KL E+ H+ + + E
Sbjct: 397 QAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYN 456
Query: 282 XXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE--LLEHLNCQIR 339
K + E+ + K LE+ E K E + + L ++
Sbjct: 457 LRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 516
Query: 340 QTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTD 399
+ N LEN+L + + + K +++ N ++ S+E Q+
Sbjct: 517 E-NSRLENELLENAEKLAEYENLTNK-----LQRNLENVLAEKFGDLDPSSAEFFLQEER 570
Query: 400 KKINKNEIAKLEMVIQSLNKDLVDK--EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQ 457
+NE + V+Q +L + EY + + ++ EH
Sbjct: 571 LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHG 630
Query: 458 QHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLND 517
E + +++ E V EQ+K++ + +I + + +L +K++ E+Q+ +
Sbjct: 631 LGSEECNPLNMSIEAE------LVIEQMKEQHHRDICCLRL-ELEDKVRHYEKQLDETVV 683
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
A +NM K H+ + ++K I + + + +E HH + EEE
Sbjct: 684 SCKKAQENM---KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHH--EATCRHEEE 738
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR---------LKAISLLESQKFDLVQ 628
K LQ+ L + + + + +M L + + L++ + E + L Q
Sbjct: 739 KKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQ 798
Query: 629 ELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK----ELALVIEN 684
EL +Q + E L + L+ +++ E+ H E + S+K L E
Sbjct: 799 EL---EQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQENSILRNEI 855
Query: 685 LKLDKEQLYGTIK-DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK---IN 740
L++E +K N ++ M K + QEN + +E + ++ISEL K ++
Sbjct: 856 TTLNEEDSISNLKLGTLNGSQEEMQKTETVKQENAAVQKMVENLK-KQISELKIKNQQLD 914
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E Q K+QE + + + + K LEE + + LER
Sbjct: 915 LENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA-LEEREQEKFNLKEELERCKV 973
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
Q + + + SE IQ +V + L+ + KQL + + Q+K +L
Sbjct: 974 QSSTLVSSLEAELSEVKIQT-HIVQQENHLLKDELEKMKQLHRCP-DLSDFQQKISSVLS 1031
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
N+ L + + N+ V+K ++ L E + + + E + + Q + Q
Sbjct: 1032 YNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASL--KSQLVASQ 1089
Query: 921 KK-KEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
+K + +ED N Q+ D +V ++ E + V L QLQ
Sbjct: 1090 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQ 1135
Score = 61.7 bits (143), Expect = 2e-08
Identities = 124/578 (21%), Positives = 249/578 (43%), Gaps = 55/578 (9%)
Query: 296 AKQSIEPSCEEKTEIEEKGSLEIAN-MTELTKKIELLEHLN----CQIRQTNKELENKLA 350
A+++++ E +T EK ++ N + EL + +L+ + C+ + K+L+ KL
Sbjct: 688 AQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 747
Query: 351 TMGT---ESKAVSSPSKKGSPLISRKSG--RNTASKMKSPWSQLSSETLNQDTDKKINKN 405
T E + + + L ++ R S W++ L Q+ ++ ++
Sbjct: 748 EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQ-FHQE 806
Query: 406 EIAKLEMVIQSLNKDLVDKEYVIS-EKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
++ L + +L K+ + KE + +++ ++ I + ++ + S
Sbjct: 807 QLTSL-VEKHTLEKEELRKELLEKHQRELQEGRYESEKLQQENSILRNEITTLNEEDSIS 865
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV-NVKDLIEKLKSAEEQITQLNDEIDAAN 523
+ +GT E+ K E +KQE K V N+K I +LK +Q+ N E+ N
Sbjct: 866 NLKLGTLNGSQEEMQKT-ETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 924
Query: 524 -KNMIKVKS-NHKL--KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHL----SQKVAELE 575
+N K++ N +L L Q +K N S + + +E L EEL S V+ LE
Sbjct: 925 SQNQEKLQELNQRLTEMLCQKEKEPGN-SALEEREQEKFNLKEELERCKVQSSTLVSSLE 983
Query: 576 EE--KGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
E + +Q H+V ++ + E + K++ +L++ + K S+L S L++E
Sbjct: 984 AELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL-SYNEKLLKEKEA 1042
Query: 633 LQQKYDEVEDKLAD-------ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENL 685
L ++ + DKLA I+ ++ +Q E +S L+ Q+ A + L ++N+
Sbjct: 1043 LSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNV 1102
Query: 686 KLD----KEQLYGTIKDLENDKEDIMN---KLQN---------YIQENMDLTDKLEKMSA 729
L K L T ++ E K+++M+ +LQN L ++ +++S
Sbjct: 1103 NLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW 1162
Query: 730 EKISELL---AKINHEEQSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
+K+ L+ ++ +E ++QT A++ + +ES L + ++
Sbjct: 1163 DKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTM 1222
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
E + SL+R+ DQ + S+ E EL
Sbjct: 1223 NPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQEL 1260
Score = 42.3 bits (95), Expect = 0.014
Identities = 70/398 (17%), Positives = 154/398 (38%), Gaps = 26/398 (6%)
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N L + ++Q + K+++ L D ++ +LRS + A + +E+
Sbjct: 386 NELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDH 445
Query: 1242 HLA---QREADFQKTEHELRVQLSAFESKY----EQLLDSV---QSSTQEETNKIVTMEQ 1291
H A + E + +K + E + +++A +++ EQ+L + ++E K T E
Sbjct: 446 HAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEEN 505
Query: 1292 ------VTSLQNKLQDKEEHLRNLQE--KYADVINQIEILRSEIEDEKVAFXXXXXXXXX 1343
SL+ + + E L N ++ +Y ++ N+++ + EK
Sbjct: 506 YIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 565
Query: 1344 XXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
+R E + ++ + + + E + + +A + +
Sbjct: 566 LQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGI 625
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDE-FENVRQQLVEYEKRIEDLTYEKESELAIL 1462
E H L ++ + E + + Q ++ ++ +E E ++ YEK+ + ++
Sbjct: 626 EPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH--YEKQLDETVV 683
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
K + E M++ E E L ++++ E L Q A L +A E + E
Sbjct: 684 SCKKAQ-----ENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEE 738
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSF 1560
+ L+ + E T E LQ+ + + Q SF
Sbjct: 739 KKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASF 776
>AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein.
Length = 2010
Score = 97.9 bits (233), Expect = 3e-19
Identities = 207/1096 (18%), Positives = 452/1096 (41%), Gaps = 103/1096 (9%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
A+ ++E L ++ +++ E + LE I+ E + LA +L+
Sbjct: 919 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 978
Query: 290 XXXXXLAKQSIE-----PSCEEKTEIEEKGSLEIA--------NMTELTKKIELLEHLNC 336
L K ++ E+ E EE+ + ++A TEL K I+ LE
Sbjct: 979 ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLA 1038
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
+ + + ENK+ + E A+ + L K A + Q + ++
Sbjct: 1039 KAEKEKQATENKVKNLTEEMAALDESVAR---LTKEKKALQEAHQQALGDLQAEEDRVSA 1095
Query: 397 DTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
T K+ + ++ LE ++ K +D E +++ D + QLE
Sbjct: 1096 LTKAKLRLEQQVEDLECSLEQEKKLRMDTER--AKRKLEGDLKLTQESVADAAQDKQQLE 1153
Query: 456 HQQHMEGPSLIHVGTNTEDVNEI-AKVQEQLKQ------ELNDEIK-DVNVKDLIEKLKS 507
+ + L + ED + A++Q+++K+ EL +E++ + + +EK ++
Sbjct: 1154 EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRA 1213
Query: 508 AE----EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
E++++ +E A+ + + +L ++++ ++ + ++ +R
Sbjct: 1214 EAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1273
Query: 560 -----LTEELHHLSQKVAELEEEKGNLQLHLVDYDSG----RMIESDVYKKMIEMEN-LA 609
L E++ L + +LE+EK L++ + D + ++ K E+ L+
Sbjct: 1274 EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1333
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEV----EDKLADISQLQSDQVCSEIKSVHLE 665
E ++K + L+ Q D + LQ + E+ E+K ISQL + + L
Sbjct: 1334 EAKIK-VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1392
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKL 724
Q++ S +K LA ++ L+ D + L ++ ++ + +LQ + + N ++
Sbjct: 1393 RQLEEESKAKSALAHAVQALRHDCDLL----REQHEEEAEAQAELQRLLSKANAEVAQWR 1448
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE-SELSKYKSRICRLEE 783
K A+ I EE + + + + + E + N + S L K K R+ E
Sbjct: 1449 SKYEADAIQRT------EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESE 1502
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ + +R S D+ +L+ +A E QE+E+ L R + +L
Sbjct: 1503 DVTLELERATSAAAALDKKQRHLE---RALEERRRQEEEMQRELEAAQRESRGLGTELFR 1559
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYN---ALVEKANRTDLA-ESESTKYQTQ 899
+ H ++E + + L EN+NLQ +SD+ + +++ +T A E E ++ Q
Sbjct: 1560 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1619
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-T 958
L + E L+ E +TL +Q E+ ++ E + ++ + L +++ +E +
Sbjct: 1620 LEEAEGALE--LEETKTLRIQ--LELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1675
Query: 959 QLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
L+A+ + +N L +E +LN + L+L H +Q T++ T ++ + A
Sbjct: 1676 SLDAETRA-RNEALRLKKKMEGDLNDLELQL--GHATRQATEAQAATRLMQAQLKEEQA- 1731
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ- 1076
+DEE L +++ + S ++L + LE E + ++LL++ +
Sbjct: 1732 --GRDEE-QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATER 1788
Query: 1077 ----HNEELQIL---------VREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPM 1121
H++ +L + + +++E + + E K T+ +++ ++
Sbjct: 1789 LNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1848
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
D + +++ L+ + EE ++Q KL +++E ++ +
Sbjct: 1849 QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKK 1908
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ E ++ ++ +L + E+ + V +L+S + S +R FE AE Q
Sbjct: 1909 HAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSY--KRQFEEAE---Q 1963
Query: 1242 HLAQREADFQKTEHEL 1257
A ++K +HEL
Sbjct: 1964 QANTNLAKYRKAQHEL 1979
Score = 87.0 bits (206), Expect = 5e-16
Identities = 194/1075 (18%), Positives = 426/1075 (39%), Gaps = 75/1075 (6%)
Query: 492 EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVS 551
E+++ +V EK A + + ++ DA + + +KS K++L+ K + ++
Sbjct: 948 ELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKS--KVQLEGKVKELSE--RLE 1003
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAET 611
D + L L + EL+++ +L+L L + + + +++NL E
Sbjct: 1004 DEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATEN------KVKNLTEE 1057
Query: 612 RLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS-VHLEEQIDA 670
++ L+ L +E LQ+ + + L D+ Q + D+V + K+ + LE+Q++
Sbjct: 1058 ----MAALDESVARLTKEKKALQEAHQQA---LGDL-QAEEDRVSALTKAKLRLEQQVED 1109
Query: 671 LSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
L S ++ + L++D E+ + LE D + + + Q+ L +KL+K +E
Sbjct: 1110 LECSLEQE----KKLRMDTERAK---RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE 1162
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
+S+L ++ E+ Q Q KI+E E +E EL ++ R+E+ A
Sbjct: 1163 -LSQLSLRVEDEQLLGAQMQ----KKIKELQARAEELEEELEAERAARARVEKQRAEAAR 1217
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA-VLMDHDRVVEKQLLEIEHENK 849
L + ++ G +++ + + L L + H+ V +
Sbjct: 1218 ELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAA 1277
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
EL ++ L Q L+ S+++ + L A++ + K D S K
Sbjct: 1278 ELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKI 1337
Query: 910 ITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN----IEYVTQLEAQLQ 965
E Q + + L+ E + ++ + +K+ L + + + + +L QL+
Sbjct: 1338 KVEELQRQLADASTQRGRLQTE-SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLE 1396
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-E 1024
E L V+ L L ++H ++ + Q+ ++ +++ N A + K E +
Sbjct: 1397 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAE--LQRLLSKANAEVAQWRSKYEAD 1454
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
I +++ A+ + + E + K ++E+ R+ + D E
Sbjct: 1455 AIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSA 1514
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
D + + L+ E + E M +E ++ + +
Sbjct: 1515 AAALDKKQRHLERA---LEERRRQEEEM--QRELEAAQRESRGLGTELFRLRHGHEEA-L 1568
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
+ E +E LQE+ + L ++ I +LE L G Q + + + LE
Sbjct: 1569 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1628
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA- 1263
T+ + ++++++ + + ++ E A L + H E+ + E R + A
Sbjct: 1629 LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL 1688
Query: 1264 -FESKYEQLLDSVQSSTQEETNKIVTMEQVTSL-QNKL------QDKEEHL-RNLQEKYA 1314
+ K E L+ ++ T + + T L Q +L +D+E+ L L E+
Sbjct: 1689 RLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQ 1748
Query: 1315 DVINQIEILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQSYKQMQEQSIL 1368
+ + +L +E+E+ + A L ++N +++
Sbjct: 1749 ALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEA 1808
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-T 1426
++ + + ++++++ + DA EL + + E +KT E T+
Sbjct: 1809 DLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRE 1868
Query: 1427 LTQRNDEFENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETM 1476
L R +E E ++Q+ + E ++ +L E ++E A+ ++ HE
Sbjct: 1869 LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAY 1928
Query: 1477 QKESEIERVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
Q E + + + +++L K+ V S +Q E + +AK + Q L++ E
Sbjct: 1929 QAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAE 1983
Score = 81.4 bits (192), Expect = 2e-14
Identities = 173/972 (17%), Positives = 382/972 (39%), Gaps = 67/972 (6%)
Query: 659 IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY----- 713
++S EE++ AL A + L + + +++L T + +K D+ +LQ
Sbjct: 916 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 975
Query: 714 -IQENMDLTDKLEKMSAEKISELLAKINHEEQ---------SKIQTQ-FGIDAKIQERDL 762
+E L K + K+ EL ++ EE+ K++ + + I + +L
Sbjct: 976 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLEL 1035
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
+ E E ++++ L E +A +++ S+ R + + + Q+A + +ED
Sbjct: 1036 TLAKAEKEKQATENKVKNLTEEMAALDE---SVARLTKEKKALQEAHQQALGDLQAEEDR 1092
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENK---ELQKKNQILLEENQNLQISLSDMQQHYNAL 879
+ + ++ VE +E E K + ++ + L + + Q S++D Q L
Sbjct: 1093 VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL 1152
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFNTQI 936
EK + D S+ + + L + +++ E Q + ++E+E Q
Sbjct: 1153 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR 1212
Query: 937 ESAIRDKKVLNEKYEK-------NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
A R+ + L+E+ E+ E + EA+L + +E + E L
Sbjct: 1213 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR-HEATVAALRRK 1271
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + D ++ ++ K + L+ + +++ A + + A+ S + YE +
Sbjct: 1272 QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ 1331
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
L++ K+E ++ ++ S Q + + EL L+ E++ I +L K ++ +
Sbjct: 1332 LSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEEL 1391
Query: 1110 EGMI---------ISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEEFIQERSVL 1157
+ ++ ++ + D + + L+ + E Q RS
Sbjct: 1392 RRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKY 1451
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
+ + + EL+E K + L E G + N + + K+KL +L TE+++ ++
Sbjct: 1452 EADAIQRTEELEEAKKK-LALRLQEAE-EGVEAANAKCSSLEKAKL-RLQTESED-VTLE 1507
Query: 1218 AELRSSISSAVD--QRGFEIA---ELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
E +S ++A+D QR E A ++ QRE + Q+ L +L +E+
Sbjct: 1508 LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEA 1567
Query: 1272 LDSVQSSTQEETN---KIVTMEQVTSLQNK-LQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L+++++ +E N +I + SL K +Q+ E+ + L+ + +++ +E +
Sbjct: 1568 LEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1627
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
E E+ L +++ ++ + A L +
Sbjct: 1628 ELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA 1687
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR---NDEFENVRQQLVEY 1444
D L+L H + +E T L + DE + + +L E
Sbjct: 1688 LRLKKKMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQ 1746
Query: 1445 EKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNV-KITESVSL 1501
+ +E +EL LR + + ++E ER+ L+ N + + L
Sbjct: 1747 AQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL 1806
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+A+L+ +EE + E + + + + +E+ Q+ A +++K +
Sbjct: 1807 EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKTLEQT 1865
Query: 1562 SDTKQGRDEQLD 1573
Q R E+ +
Sbjct: 1866 VRELQARLEEAE 1877
Score = 69.7 bits (163), Expect = 8e-11
Identities = 157/854 (18%), Positives = 346/854 (40%), Gaps = 77/854 (9%)
Query: 213 DTKQQMTKMQENF-IAME--AEWKDEKQRLLKDIESKDVRISSLE---EANKLLEAARFE 266
DT++ K++ + + E A+ +KQ+L + ++ KD +S L E +LL A +
Sbjct: 1123 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 1182
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
E A+ELE+ ++ E +EE G K
Sbjct: 1183 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1242
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
+ L L ++ + L ++ K ++ G + S + R K KS
Sbjct: 1243 REAELGRLRRELEEA--ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSEL 1300
Query: 387 SQ------LSSETLNQ---DTDK--KINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
+ ETL + +K + ++++++ ++ ++ L + L D T
Sbjct: 1301 RMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTES 1360
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLK----- 486
K+ LI+ QL + + SL + E+ ++ +A + L+
Sbjct: 1361 GELSRLLEEKECLIS--QLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1418
Query: 487 -QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDA----ANKNMIKVKSNHKLKLKQMQ 541
+E ++E + +L L A ++ Q + +A + + + K L+L++ +
Sbjct: 1419 LREQHEEEAEAQA-ELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE 1477
Query: 542 KTIDNF-SKVSDSNKEIVRL-------TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+ ++ +K S K +RL T EL + A L++++ +L+ L + R
Sbjct: 1478 EGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL---EERRR 1534
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
E ++ +++ + + + L + ++ L L+++ ++++++D+ +D
Sbjct: 1535 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDL----TD 1590
Query: 654 QVCSEIKSV-HLEEQIDALSASKKELALVIEN----LKLDKEQLYGTIKDLENDKEDIMN 708
QV KS+ LE+ AL K E+ +E L+L++ + +L K ++
Sbjct: 1591 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1650
Query: 709 KLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE 768
KL +E +L + + + E + L ++ + ++ + + +L + +
Sbjct: 1651 KLAEKDEECANLR-RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHAT 1709
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ ++ ++ ++ + + R +R A +L Q ++ S + +EL L
Sbjct: 1710 RQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1769
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
R+ E++LLE L +N LL + + L+ +D+ Q + E A
Sbjct: 1770 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE---ADLAQLSGEVEEAAQERRE 1826
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE----SAIRDKK 944
AE ++ K T + LK+ + + + KK +E E ++E +A+R K
Sbjct: 1827 AEEKAKKAITDAAMMAEELKK-EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGK 1885
Query: 945 VLNEKYEKNI-EYVTQLEAQ----------LQEYKNNIENLNMNVEELNKMNLELIDKHV 993
+K E + E +L+A+ +++++ ++ L EE ++ NL + V
Sbjct: 1886 KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEE-DRKNLARMQDLV 1944
Query: 994 QKQQTQSPDYTEQY 1007
K Q++ Y Q+
Sbjct: 1945 DKLQSKVKSYKRQF 1958
Score = 57.2 bits (132), Expect = 5e-07
Identities = 138/704 (19%), Positives = 286/704 (40%), Gaps = 53/704 (7%)
Query: 233 KDEKQRLLKDIESK--DVRISSLEEANKLLEAA--RFEISLEHSKLAQELEQXXXXXXXX 288
K ++L + E + + +I E +L +A+ R + E +L++ LE+
Sbjct: 1318 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL 1377
Query: 289 XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELEN 347
LA QS+E + E E K +A+ + L +LL + + + EL+
Sbjct: 1378 SRGKA-LAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQR 1435
Query: 348 KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
L+ E SK + I R A K + Q + E + + + K + E
Sbjct: 1436 LLSKANAE--VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV-EAANAKCSSLEK 1492
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
AKL + +S + L + E S + Q + E Q+ +E
Sbjct: 1493 AKLRLQTESEDVTL-ELERATSAAAALDKKQRHLERALEERRRQEE-EMQRELEAAQRES 1550
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
G TE + + E+ + L + +K N K+L E++ +Q++ I K
Sbjct: 1551 RGLGTE-LFRLRHGHEEALEAL-ETLKREN-KNLQEEISDLTDQVSLSGKSIQELEKTK- 1606
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL--TEELHHLSQKVAELEEEKGNLQLHL 585
K K +++ + + ++ ++ ++L ++ + +K+AE +EE NL+ +
Sbjct: 1607 KALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRN- 1665
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETR-LKAISLLESQKFDLVQEL-HILQQKYDEVEDK 643
R +ES + ++ E A L+ +E DL +L H +Q +
Sbjct: 1666 ----HQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1719
Query: 644 LADISQLQSDQVCSEIK---SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+QL+ +Q + + + L EQ AL LA +E L+ EQ + + E
Sbjct: 1720 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1779
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ + +L +N L ++ +K+ A+ +++L ++ Q + + + I +
Sbjct: 1780 QELLEATERLNLLHSQNTGLLNQKKKLEAD-LAQLSGEVEEAAQERREAEEKAKKAITDA 1838
Query: 761 DLYIENI--ESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY---- 813
+ E + E + S + R+ + LE+++ ++ R E+ A + G +K +A
Sbjct: 1839 AMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL 1898
Query: 814 -SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-------------- 858
+E ++ + L + H+R V++ + E + K L + ++
Sbjct: 1899 EAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 1958
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
E Q +L+ ++ + L + R D+AE+++ K + + RD
Sbjct: 1959 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 2002
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 97.5 bits (232), Expect = 3e-19
Identities = 177/932 (18%), Positives = 402/932 (43%), Gaps = 85/932 (9%)
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E +D L+ E ++E+++ E + E+ E ++Q +A I++
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRE-LEEMRVTYGTEGLQQLQE---FEAAIKQ 202
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
RD I + + L + + + ++ L+ + QL + + +S
Sbjct: 203 RDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA- 261
Query: 820 EDELVNRLAVLMDHDRVVEKQ--LLEIEHENKE--------LQKKNQIL-LEENQNLQIS 868
+L+ ++ H + +E+Q LLE + KE LQ+K ++ +E+++ ++ S
Sbjct: 262 --DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENS 319
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ Q ++E+ N T + E E K +L+D + ++ E Q IVQK +EI+++
Sbjct: 320 NKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLE 987
++E + + + + + E + Q + ++ + + +L ++ E
Sbjct: 377 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 436
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQVSYMSM-VS 1044
L + + Q+ + Q++ ++ ++ K + E + N +N Q+ M++ ++
Sbjct: 437 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ KL ++ E ++EE+ + ++ ++ E+L + +QI+ ++T E
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + + ST+E + + L+++ E E + L+ +
Sbjct: 557 KLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKIKLEMLEKEK 607
Query: 1165 NTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN--DNLLSTVA 1218
N L ++ +LE L T+L ++E++++LK LE ++N E DNL
Sbjct: 608 NAVLDRMAESQEAELERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 664
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKYEQL---LDS 1274
+ + + + Q+ E + K +L ++ +L+ +Q S SK E++ ++
Sbjct: 665 QQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 1275 VQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q QEE K ++V LQ K + E+ ++ + + Q+E S ++DE
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Query: 1331 KVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
K +++S + E+ I + EEN LK+
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
+ AE K E+ +Q EL++ EY L ++D ++ +Q +EY+ ++
Sbjct: 844 EKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNKQELEYKSKL 893
Query: 1449 ----EDLTYEKESELAI-LRLKMHENANHY--ETMQKESEIER--VKLIEELNVKITESV 1499
E+L ++ + + ++ + + + ET++ +E+ +L+E+L V E +
Sbjct: 894 KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKL 953
Query: 1500 SLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L++++++L++ L+ EEV K + Q +L +E+EI+ ++ N+Q+
Sbjct: 954 ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCD 1013
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
SS + V+ S +G +++ + +E
Sbjct: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
Score = 89.0 bits (211), Expect = 1e-16
Identities = 198/993 (19%), Positives = 421/993 (42%), Gaps = 93/993 (9%)
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
+I + N+ELE T GTE ++ I ++ G T QL++
Sbjct: 170 EIEELNRELEEMRVTYGTEGL---QQLQEFEAAIKQRDGIIT---------QLTANLQQA 217
Query: 397 DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISE---KDTXXXXXXXXXXGKDTLIA-QL 452
+K E LE+ QS + ++ SE T K ++ Q
Sbjct: 218 RREKDETMREF--LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ 275
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ 511
QLE Q H+ L ED +I+ +QE++K ++ K V + E+++ E
Sbjct: 276 QLEEQDHL----LEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETI 330
Query: 512 ITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKEIVRLTEELHHLSQK 570
I +LN +I K +++K KL K + + + N+EI + EL + QK
Sbjct: 331 IEELNTKIIEEEKKTLELKD----KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 571 VAELEEEKGNLQLHLVDYDSGR----MIESDVYKKMIE--MENLAETRLKAISLLESQKF 624
+ EE L + + E+D+ ++M + L + R + + Q
Sbjct: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
+ QEL ++Q ++E+ + + S E+QI ++ + EL + +++
Sbjct: 447 QMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN--HE 742
KE+L + + +K + +L++ ++E +++++ + + I+E +K+N H+
Sbjct: 505 TNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQR-ARQTIAEQESKLNEAHK 563
Query: 743 EQSKIQTQFG--IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
S ++ + A ++L +++ E+E++ YK ++ LE +++ L+R A+
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKH-EAEVTNYKIKLEMLE------KEKNAVLDRMAE 616
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
S E ++ ++ +E +++L K+ LEIEH + K+ + +
Sbjct: 617 ---SQEAELERLRTQLLFSHEEELSKL-----------KEDLEIEHRINIEKLKDNLGIH 662
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL-IV 919
Q + ++M Q + + + +++ ++L+DL+ +L E TL I
Sbjct: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 722
Query: 920 QKKKEIEDLEIEFNTQ--IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
+ +KEIE L E + +E +++ ++ E EK ++ + E LQE +E N
Sbjct: 723 ELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK---EKENDLQEKFAQLEAENSI 779
Query: 978 VEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQV 1037
+++ K +++ H Q + + + I +K +++ +++ E +I N+ +
Sbjct: 780 LKDEKKTLEDMLKIHTPVSQEERLIFLDS-IKSKSK-DSVWEKEIEILIEENEDLKQ--- 834
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ + + E + F+ +N E Q + ++ + ++L+ +Q+ + K K
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS-KL 893
Query: 1098 TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVL 1157
L E+++ + I+ T M + D + ++ E +++ V
Sbjct: 894 KALNEELHLQR-----INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVT 948
Query: 1158 QEQSAKLNTELQECYTKIIQ----LETLNTELTGHDVVNQEQINQLKSKLEQLNTEN--D 1211
+ + +L+ L + ++ Q + LN E+ +EQ++ +LE + N +
Sbjct: 949 KREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK-QEKEQVSLRCRELEIIINHNRAE 1007
Query: 1212 NLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF--ESK 1267
N+ S ++ S + V RG E + K + + E E ++ + ESK
Sbjct: 1008 NVQSCDTQVSSLLDGVVTMTSRGAE-GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 1268 YEQL-LDSVQSSTQEETNKIVTMEQVTSLQNKL 1299
EQL LD + S T+E + + + LQ +L
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKEL 1099
Score = 74.9 bits (176), Expect = 2e-12
Identities = 112/551 (20%), Positives = 238/551 (43%), Gaps = 32/551 (5%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 471 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 529
Query: 207 XXXXXED---TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
E+ +++Q+ + ++ E++ +E + L +E I S E+ K LE
Sbjct: 530 LEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELEL- 587
Query: 264 RFEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIA 319
+ E + + K+ E+ E+ L + + + E+ + K LEI
Sbjct: 588 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Query: 320 NMTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRN 377
+ + K K L H QI E+ K+ TM E + + + IS+ K +
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 707
Query: 378 TASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
+ KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 708 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 767
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 768 EKFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEK 820
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 821 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLE 879
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 880 DSKNKQELEYKS-KLKALNEE---LHLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMG 931
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
++E +L+++L + +++ E+ +L+D+S+ Q Q EI L E++ +L K+
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEIS--FLNEEVKSLKQEKE 988
Query: 677 ELALVIENLKL 687
+++L L++
Sbjct: 989 QVSLRCRELEI 999
Score = 65.7 bits (153), Expect = 1e-09
Identities = 130/687 (18%), Positives = 274/687 (39%), Gaps = 61/687 (8%)
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + +E I +T I + ++ + + ++E +++ + + + +
Sbjct: 65 MYINSSQRVESTVIPEST-IMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ NL L ++ + S + + + + L K EI LN+++ +
Sbjct: 124 VMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR 182
Query: 1037 VSY----MSMVSDYESKL-------AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
V+Y + + ++E+ + Q T L+ E ++ L+ + +++LQI
Sbjct: 183 VTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242
Query: 1086 RE--QDDQIKELKETKLTFEMNIPKTEGMIISSTIEP----MSDDANNVDXXXXXXXXXX 1139
++ + ++ + ++ K + + +E + D +
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+KV E E+ + + +E+ + T ++E TKII+ E EL + + +L
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
Query: 1200 KSKLEQLNTENDNL---LSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADF-QKT 1253
+ ++ Q N E N+ L+ + S + Q + EL K++ +Q E D Q+
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Query: 1254 EHELRVQLSAFESKYEQLLDS--VQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNL- 1309
E E + +L ++ +++ VQ + + ME++ T + ++++ N+
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482
Query: 1310 ----QEKYADV-INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQM 1362
Q K +V IN++ I + +K L E S+ +
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 1363 Q-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA-KVLELTHQLELKDSEI---- 1416
Q +++ I E+ ++L ++ V+ +E+ K LEL H+ E+ + +I
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602
Query: 1417 --YQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIEDLTYEKESELAILRLKMHENAN-H 1472
+K + E E +R QL+ +E+ + L + E E I K+ +N H
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
Query: 1473 Y---------ETMQK--ESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEEVAKTN 1520
Y E QK + E+ LI + N I E L + Q + +N EE + N
Sbjct: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 722
Query: 1521 EMQTALE---NQEIEIVTLNDEITNLQ 1544
E+Q +E +E E TL E+ LQ
Sbjct: 723 ELQKEIEILRQEEKEKGTLEQEVQELQ 749
>AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein.
Length = 3911
Score = 97.5 bits (232), Expect = 3e-19
Identities = 177/932 (18%), Positives = 402/932 (43%), Gaps = 85/932 (9%)
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E +D L+ E ++E+++ E + E+ E ++Q +A I++
Sbjct: 159 EQGAQDSPTHLEMMESELAGKQHEIEELNRE-LEEMRVTYGTEGLQQLQE---FEAAIKQ 214
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
RD I + + L + + + ++ L+ + QL + + +S
Sbjct: 215 RDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA- 273
Query: 820 EDELVNRLAVLMDHDRVVEKQ--LLEIEHENKE--------LQKKNQIL-LEENQNLQIS 868
+L+ ++ H + +E+Q LLE + KE LQ+K ++ +E+++ ++ S
Sbjct: 274 --DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENS 331
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ Q ++E+ N T + E E K +L+D + ++ E Q IVQK +EI+++
Sbjct: 332 NKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 388
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLE 987
++E + + + + + E + Q + ++ + + +L ++ E
Sbjct: 389 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 448
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQVSYMSM-VS 1044
L + + Q+ + Q++ ++ ++ K + E + N +N Q+ M++ ++
Sbjct: 449 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 508
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ KL ++ E ++EE+ + ++ ++ E+L + +QI+ ++T E
Sbjct: 509 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 568
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + + ST+E + + L+++ E E + L+ +
Sbjct: 569 KLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKIKLEMLEKEK 619
Query: 1165 NTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN--DNLLSTVA 1218
N L ++ +LE L T+L ++E++++LK LE ++N E DNL
Sbjct: 620 NAVLDRMAESQEAELERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 676
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKYEQL---LDS 1274
+ + + + Q+ E + K +L ++ +L+ +Q S SK E++ ++
Sbjct: 677 QQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 735
Query: 1275 VQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q QEE K ++V LQ K + E+ ++ + + Q+E S ++DE
Sbjct: 736 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 795
Query: 1331 KVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
K +++S + E+ I + EEN LK+
Sbjct: 796 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 855
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
+ AE K E+ +Q EL++ EY L ++D ++ +Q +EY+ ++
Sbjct: 856 EKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNKQELEYKSKL 905
Query: 1449 ----EDLTYEKESELAI-LRLKMHENANHY--ETMQKESEIER--VKLIEELNVKITESV 1499
E+L ++ + + ++ + + + ET++ +E+ +L+E+L V E +
Sbjct: 906 KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKL 965
Query: 1500 SLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L++++++L++ L+ EEV K + Q +L +E+EI+ ++ N+Q+
Sbjct: 966 ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCD 1025
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
SS + V+ S +G +++ + +E
Sbjct: 1026 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1057
Score = 89.8 bits (213), Expect = 7e-17
Identities = 273/1454 (18%), Positives = 583/1454 (40%), Gaps = 129/1454 (8%)
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQ 276
Q + ++ I E E ++ +K E+ V L+E KL++ + E+ + K+
Sbjct: 1972 QELEAEQQQIQEERELLSRQKEAMK-AEAGPVEQQLLQETEKLMKE-KLEVQCQAEKVRD 2029
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNC 336
+L++ + IE E+ TE+ + A +L K + L+
Sbjct: 2030 DLQKQVKALEIDVEEQ---VSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI 2086
Query: 337 QIRQTNKELENKLATMGTESKAVS--SP-SKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+ ++ + + K V P S+ + + + + K LS E
Sbjct: 2087 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2146
Query: 394 LNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQ 453
L +D ++ EI KLE ++ L + L + DT G +L
Sbjct: 2147 LQRDIQER--NEEIEKLEFRVRELEQAL------LVSADTFQKVEDRKHFGAVEAKPELS 2198
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL---NDEIKDVNVKDLIEKLKSAE- 509
LE Q E + + +++ + + EQ ++EL N+E++ ++++ I+K +S
Sbjct: 2199 LEVQLQAERDA---IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2255
Query: 510 -EQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SDSNKEIVRLTEELHH 566
+++ Q N D K + +K + + + F+++ + EI +L E++
Sbjct: 2256 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2315
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
L Q++ + K + + + D +E+ + M + E + R + I L L
Sbjct: 2316 LQQQLKITTDNKVIEEKNELIRD----LETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2371
Query: 627 VQELHILQQKYDEVEDKL---ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
QEL + QK L AD + Q D V +E + LE+Q++ + + V++
Sbjct: 2372 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE--KLALEQQVETANEEMTFMKNVLK 2429
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
QL + L+ ++E + K+Q+ + ++++ ++ +S +K EL + +
Sbjct: 2430 ETNFKMNQLTQELFSLKRERESV-EKIQSIPENSVNVA--IDHLSKDK-PELEVVLTEDA 2485
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC----RLEESIAVMEDRRYSLERKA 799
++ Q + + I N+E+ L + +S + L + ++D + + +
Sbjct: 2486 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 2545
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE-KQLLEIEHENKELQKKNQIL 858
+ L + QK E +L + ++ + + Q + E E +Q NQ+
Sbjct: 2546 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 2605
Query: 859 LEENQN----LQISLSDMQQH----YNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
+E + L + +S+++ + +L+ + + ++AE + + +L +L+ L+
Sbjct: 2606 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG- 2664
Query: 911 THEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
+E + +KK+ +D+E+ + T++ + + NE E V +A+L YK
Sbjct: 2665 -NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT-KAELASYKE 2722
Query: 970 NIENLN--MNVEELNKMNLEL----IDKHVQKQQT-----QSPDYTEQYINE-------- 1010
E L + V+E N +L+ + H+ + + + D TE ++
Sbjct: 2723 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2782
Query: 1011 -INKLNALLKQKDE--EIIALNQK----INNA--QVSYMSMVSDYESK--LAQFTTKLEN 1059
I ++ Q D +I + NQ + NA Q++ S S E ++QFT K+E
Sbjct: 2783 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2842
Query: 1060 MEEEMQRVSKQLLD-SKQHNEELQILVREQDDQIKELKE----TKLTFEMNIPKTEGMII 1114
M+E + ++LD +H E + L RE ++ LKE K + K
Sbjct: 2843 MQE---LHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFY 2899
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ + D + D + E + S K+ L+ + +
Sbjct: 2900 NMCFSTLCDSGS--DWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE 2957
Query: 1175 IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
+Q+ +L TE D I Q+ E E ++T++ L+ I+ QR E
Sbjct: 2958 GMQVLSL-TESPYSD-GEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAE 3012
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTS 1294
+ + + H + +D+ + E L +Q E + L T T V + +
Sbjct: 3013 VYDSSQSH--ESFSDW-RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL--LNC 3067
Query: 1295 LQNKLQDKEEHLRNLQE--KYAD---VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXX 1349
L+ ++Q++ + E + AD ++++I+ L +++ K+
Sbjct: 3068 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3127
Query: 1350 XDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL 1409
+++ + +MQ + + ++ + +L++ + A+ K LEL L
Sbjct: 3128 YNIQQKQSQMLEMQVE-LSSMKDRATELQEQLSSEKMVVAELKSEL--AQTK-LELETTL 3183
Query: 1410 ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
+ + + ++ + + + + DE + L +K+ +L + E E A L +
Sbjct: 3184 KAQHKHL-KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3242
Query: 1470 ANHYETM------QKESEIERVKLIEELNVKITES-VSLNKQVAELNKALEEEVAKTNEM 1522
E + QK+ ++ L+E+ + ES + Q + L EE + E+
Sbjct: 3243 KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLEL 3302
Query: 1523 QTALENQEIEIVTLN---DEITNLQNMVRASSSKIQKHVSFAS-DTKQGRDEQLDNTMNK 1578
Q LE++++ I ++ D L +++S Q S D + +QL+ ++
Sbjct: 3303 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR 3362
Query: 1579 --ELLDAVPRAELD 1590
ELL+ + +LD
Sbjct: 3363 IVELLNETEKYKLD 3376
Score = 89.4 bits (212), Expect = 9e-17
Identities = 160/818 (19%), Positives = 358/818 (43%), Gaps = 84/818 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQI 512
QLEH + + + ++ E K QE+L++ L++E + + L +L AE I
Sbjct: 1879 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR--AREQLAVELSKAEGVI 1936
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
DE + I+ K++ +L+Q N ++ + E ++ EE LS++
Sbjct: 1937 DGYADE-KTLFERQIQEKTDIIDRLEQELLCASN--RLQELEAEQQQIQEERELLSRQKE 1993
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
++ E G ++ L+ E E L + +L+ E + DL +++
Sbjct: 1994 AMKAEAGPVEQQLLQ----------------ETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2037
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+ +VE++++ +L+ ++ + + L +Q AL +++ ++ +D+E
Sbjct: 2038 LE---IDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH- 2090
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKIQTQF 751
+ D+ + +++ + + + + +S + E+ NH +E++ ++
Sbjct: 2091 ----------ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2140
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ + +RD+ N E+ K + R+ LE+++ V D +E + G+ ++ K +
Sbjct: 2141 LLSKEQLQRDIQERN--EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHFGA-VEAKPE 2196
Query: 812 AYSEYTIQ--EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
E +Q D + + + + + +E+ E+E++N+E+Q+ + L + + L
Sbjct: 2197 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2256
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDL 928
+++Q + + LA ES TQ + L +I E + I Q +++ L
Sbjct: 2257 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2316
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ Q D KV+ EK E + TQ+E + + + N +E+LN++ +E
Sbjct: 2317 Q-----QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV-IEK 2370
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN--NAQVSYM-SMVSD 1045
+ + + ++ E + L L E +AL Q++ N ++++M +++ +
Sbjct: 2371 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2430
Query: 1046 YESKLAQFTTKLENMEEEMQRVSK-QLLDSKQHNEELQILVREQ--------DDQIKELK 1096
K+ Q T +L +++ E + V K Q + N + L +++ +D +K L
Sbjct: 2431 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL- 2489
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
E + F+ +G II+ + + A +++ + Q E E +Q
Sbjct: 2490 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2549
Query: 1153 ER-----SVLQEQSA-----KLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQI--NQL 1199
++ +++E+ A ++ E + Y K Q +T+++E ++ N Q+ ++L
Sbjct: 2550 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2609
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
S + L L S V E+ +S+ +++ EIAE
Sbjct: 2610 GSDISALTLRISELESQVVEMHTSL--ILEKEQVEIAE 2645
Score = 88.6 bits (210), Expect = 2e-16
Identities = 177/942 (18%), Positives = 395/942 (41%), Gaps = 61/942 (6%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 483 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 541
Query: 207 XXXXXED---TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
E+ +++Q+ + ++ E++ +E + L +E I S E+ K LE
Sbjct: 542 LEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELEL- 599
Query: 264 RFEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIA 319
+ E + + K+ E+ E+ L + + + E+ + K LEI
Sbjct: 600 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 659
Query: 320 NMTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRN 377
+ + K K L H QI E+ K+ TM E + + + IS+ K +
Sbjct: 660 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 719
Query: 378 TASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
+ KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 720 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 779
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 780 EKFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEK 832
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 833 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLE 891
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 892 DSKNKQELEYKS-KLKALNEE---LHLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMG 943
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
++E +L+++L + +++ E+ +L+D+S+ Q Q EI L E++ +L K+
Sbjct: 944 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEIS--FLNEEVKSLKQEKE 1000
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+++L L++ + +++++ + + L + +T + + S K+++
Sbjct: 1001 QVSLRCRELEIIIN--HNRAENVQSCDTQVSSLLDGVV----TMTSRGAEGSVSKVNKSF 1054
Query: 737 ---AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+KI E++ + + + ++ L ++++ S + R + E+ + ++
Sbjct: 1055 GEESKIMVEDKVSFE-NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 1113
Query: 794 SLERKADQLGSYLQEKQKAYS-EYTIQEDELVNRLAVLMDHD--RVVEKQLLEIEHENKE 850
L+ + + L ++ ++ S Y+ D++ + D + E+ + E + KE
Sbjct: 1114 -LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1172
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE---------SESTKYQTQLR 901
LQK +Q+ L+ + + D + + L+ K + E S +Y T
Sbjct: 1173 LQKIHQLELQTMKTQE--TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1230
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
E N + + + + E++D E E+ + E+Y K + T+L
Sbjct: 1231 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL- 1289
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+++ + + L E L K E + H Q T D + ++++ L L K K
Sbjct: 1290 SKIWGQQTDGMKLEFGEENLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSLQDLEKTK 1347
Query: 1022 -DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
+E++ L I++ Q +YE+++ +L+ + E
Sbjct: 1348 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1389
Score = 74.5 bits (175), Expect = 3e-12
Identities = 178/974 (18%), Positives = 401/974 (41%), Gaps = 103/974 (10%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS----ASKKELALVIENLKLD 688
LQ++ + +LA S + ++ + SE + V LEE ++AL A +++L + N
Sbjct: 1638 LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE-LEALKQLSLAGREKLCCELRNSSTQ 1696
Query: 689 KE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
+ + G +++ ++++ K ++ E + E+ + +K + L KI E
Sbjct: 1697 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL----SNERYALQKANNRLLKILLE--- 1749
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
++T ++ I L I + S+ S I R E +V R D
Sbjct: 1750 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD----- 1804
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN-QILLEENQN 864
E +YS + ++ +N + + + + ++L+ E+ +N +++L +
Sbjct: 1805 --ESIPSYSGSDMPRND-INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR 1861
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE 924
LQ ++ + + + + + ++E + + + + + E + + ++ +
Sbjct: 1862 LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1921
Query: 925 IEDLEIEFNTQ---IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
E L +E + I+ +K + + ++ + + +LE +L N ++ L +++
Sbjct: 1922 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQI 1981
Query: 982 NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
+ EL+ + + + ++ +Q + E K L+K+K E + ++ Q +
Sbjct: 1982 QE-ERELLSRQKEAMKAEAGPVEQQLLQETEK---LMKEKLEVQCQAEKVRDDLQKQVKA 2037
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ----DDQIKELKE 1097
+ D E ++++F +LE Q + +L+D +Q N+ L+ + + D+Q + +
Sbjct: 2038 LEIDVEEQVSRF-IELE------QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2090
Query: 1098 TKLTFEMNIPKTEGMI-ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ F+ I K E + + +P+S+ K + E + +
Sbjct: 2091 ERDVFQQEIQKLEQQLKVVPRFQPISEH----QTREVEQLANHLKEKTDKCSELLLSKEQ 2146
Query: 1157 LQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLE-----QLNTE 1209
LQ + N E+++ ++ +LE L + T V +++ +++K E QL E
Sbjct: 2147 LQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE 2206
Query: 1210 NDNL------LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA 1263
D + ++ + E ++ + E+ +L Q Q++ + + EL +
Sbjct: 2207 RDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENKL 2265
Query: 1264 FESKYEQL-LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
F+ E+L L +S ++ V + + +Q+KE + L E+ + Q++I
Sbjct: 2266 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI---IQEKEVEIDQLNEQVTKLQQQLKI 2322
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSX 1382
D KV L ++ + K+ +E+ I +NE +L++
Sbjct: 2323 ----TTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2376
Query: 1383 XXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
+++ EA L HQL++ +E + L Q
Sbjct: 2377 NIGQKTSMNAHSLSE-EAD--SLKHQLDVVIAE--------KLALEQ------------- 2412
Query: 1443 EYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE-IERVKLIEELNVKITESVSL 1501
+ E E++T+ K + L KM++ ++++E E +E+++ I E +V + L
Sbjct: 2413 QVETANEEMTFMK-NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID-HL 2470
Query: 1502 NKQVAELNKALEEEVAKTNEMQTAL----ENQEIEIVTLNDEITNLQNMVRASSSKI-QK 1556
+K EL L E+ K+ E QT EN + I+ L + L++ V A ++ Q
Sbjct: 2471 SKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQC 2530
Query: 1557 HVSFASDTKQGRDE 1570
+ +QG+ E
Sbjct: 2531 YKQIKDMQEQGQFE 2544
Score = 65.7 bits (153), Expect = 1e-09
Identities = 130/687 (18%), Positives = 274/687 (39%), Gaps = 61/687 (8%)
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + +E I +T I + ++ + + ++E +++ + + + +
Sbjct: 77 MYINSSQRVESTVIPEST-IMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 135
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ NL L ++ + S + + + + L K EI LN+++ +
Sbjct: 136 VMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR 194
Query: 1037 VSY----MSMVSDYESKL-------AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
V+Y + + ++E+ + Q T L+ E ++ L+ + +++LQI
Sbjct: 195 VTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 254
Query: 1086 RE--QDDQIKELKETKLTFEMNIPKTEGMIISSTIEP----MSDDANNVDXXXXXXXXXX 1139
++ + ++ + ++ K + + +E + D +
Sbjct: 255 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 314
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+KV E E+ + + +E+ + T ++E TKII+ E EL + + +L
Sbjct: 315 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 374
Query: 1200 KSKLEQLNTENDNL---LSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADF-QKT 1253
+ ++ Q N E N+ L+ + S + Q + EL K++ +Q E D Q+
Sbjct: 375 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 434
Query: 1254 EHELRVQLSAFESKYEQLLDS--VQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNL- 1309
E E + +L ++ +++ VQ + + ME++ T + ++++ N+
Sbjct: 435 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 494
Query: 1310 ----QEKYADV-INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQM 1362
Q K +V IN++ I + +K L E S+ +
Sbjct: 495 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 554
Query: 1363 Q-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA-KVLELTHQLELKDSEI---- 1416
Q +++ I E+ ++L ++ V+ +E+ K LEL H+ E+ + +I
Sbjct: 555 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 614
Query: 1417 --YQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIEDLTYEKESELAILRLKMHENAN-H 1472
+K + E E +R QL+ +E+ + L + E E I K+ +N H
Sbjct: 615 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 674
Query: 1473 Y---------ETMQK--ESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEEVAKTN 1520
Y E QK + E+ LI + N I E L + Q + +N EE + N
Sbjct: 675 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 734
Query: 1521 EMQTALE---NQEIEIVTLNDEITNLQ 1544
E+Q +E +E E TL E+ LQ
Sbjct: 735 ELQKEIEILRQEEKEKGTLEQEVQELQ 761
Score = 58.4 bits (135), Expect = 2e-07
Identities = 93/502 (18%), Positives = 206/502 (41%), Gaps = 36/502 (7%)
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
+N ++ L D ++ K L+ E E + + ++ + L ++L + +++ A
Sbjct: 2992 INTISSLKD---LITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3048
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI--VQKK------KEIEDLEIEFNTQ 935
RT+L +T L LE ++ E+Q + +QK EI+ L + N +
Sbjct: 3049 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3108
Query: 936 IESAIRDK---KVLNEKYEKNIEY----VTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ R++ K E E NI+ + +++ +L K+ L + + EL
Sbjct: 3109 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3168
Query: 989 IDKHVQKQQTQSPDYTEQY--INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+ Q + Q+ + E+ +K K +E+ LN + + Q +
Sbjct: 3169 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3228
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
E + A+ E +EE++ + L KQ N +L +L+ +Q + E ++ ++ +
Sbjct: 3229 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3288
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS- 1161
+ + + +G + + S+ + ++Q + Q R L +
Sbjct: 3289 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3348
Query: 1162 -AKLNTELQECYTKIIQL--ET----LNTELTGHDVVNQEQINQLKSKLEQ-LNTENDNL 1213
+L +L+E +++I++L ET L++ T + Q+++ + EQ NTE
Sbjct: 3349 LKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKK 3408
Query: 1214 LSTVAELRSSISSAVDQRGFEI--AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+ + + ++++ ++ +L Q L +FQK E E + + Y+ L
Sbjct: 3409 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3468
Query: 1272 LD-SVQSSTQEETNKIVTMEQV 1292
+ + S T + T V +++
Sbjct: 3469 NEPTTWSLTSDRTRNWVLQQKI 3490
Score = 55.2 bits (127), Expect = 2e-06
Identities = 146/750 (19%), Positives = 326/750 (43%), Gaps = 73/750 (9%)
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKSVHLEEQ 667
E R I+ + S K DL+ ++ + Q+ EV D ++ ++ V LEE+
Sbjct: 2986 EERKAYINTISSLK-DLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEER 3042
Query: 668 IDALSASKKEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
L+A + EL AL + L I++ + + M LQ + L +++
Sbjct: 3043 SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSEIQA 3100
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ A+ + + E++S+ +Q ++ IQ++ + ++ ELS K R L+E ++
Sbjct: 3101 LHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3159
Query: 787 ----VMEDRRYSLERKADQLGSYLQEKQKAYSE---YTIQEDELVNRLAVLMDHDRVVEK 839
V+ + + L + +L + L+ + K E + ++ + + + +L D +K
Sbjct: 3160 SEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK 3219
Query: 840 QLLE----IEHENKELQKKNQILLEENQNLQISLSDMQQ---HYNALVEKANR-----TD 887
+ E +E E +L + + EE ++L+ SL +Q N L+E+ +
Sbjct: 3220 KSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3279
Query: 888 LAESESTKYQTQLRDLES-NLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
ES+ Y QL + + NL+ ++ E + + +++ D E E + Q++S+ D
Sbjct: 3280 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS--DGTG 3337
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+ + + + +L+ QL+E + I L +N E K++ L + ++ Q T
Sbjct: 3338 QSRPPLPSEDLLKELQKQLEEKHSRIVEL-LNETEKYKLD-SLQTRQQMEKDRQVHRKTL 3395
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
Q E N + +++ L K+ + Q + + ++ + + + ++ MQ
Sbjct: 3396 QTEQEAN------TEGQKKMHELQSKVEDLQ----RQLEEKRQQVYKLDLEGQRLQGIMQ 3445
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
KQ L+ ++ E +IL + ++ T+ + +T ++ IE + ++
Sbjct: 3446 EFQKQELEREEKRESRRILYQNLNE--------PTTWSLTSDRTRNWVLQQKIEGETKES 3497
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N E E I+++ LQ ++KL L + ++ +Q ET + E
Sbjct: 3498 NYAKLIEMNGGGTG----CNHELEMIRQK--LQCVASKLQV-LPQKASERLQFETADDE- 3549
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ QE I+++ +L++L + S V+ +S S ++ + AEL H++Q
Sbjct: 3550 --DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTERLLRQNAEL-TGHISQ 3605
Query: 1246 READFQKTEHELRVQLSAFESK---YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+ +++LR + E + Y Q +S++ N +E + + + ++ ++
Sbjct: 3606 ----LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNR 3661
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
E+ LQ+ ++ L++E+ ++ +
Sbjct: 3662 EK--LTLQKSLKRAEAEVYKLKAELRNDSL 3689
Score = 52.4 bits (120), Expect = 1e-05
Identities = 158/800 (19%), Positives = 328/800 (41%), Gaps = 81/800 (10%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-LLEAARFEISLEHSK 273
KQQ+ +Q + EK L+ + IS L++ + L+ + E++L+ ++
Sbjct: 676 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 735
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
L +E+E +Q ++ + KTE+ EK E N +L +K LE
Sbjct: 736 LQKEIE-----ILRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKEN--DLQEKFAQLEA 787
Query: 334 LNCQIRQTNKELENKL---ATMGTESKAV--SSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
N ++ K LE+ L + E + + S K + K + + Q
Sbjct: 788 ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 847
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY--VISEKDTXXXXXXXXXXGKD 446
LN++ +K+ N A+ + N + +EY ++ KD
Sbjct: 848 CIQ--LNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDLEDSKNKQELEYK 902
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVN--------EIAKVQEQLKQELNDEIKDVNV 498
+ + L E P+ + + ++ D + E+ +V E+ EL ++++
Sbjct: 903 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 962
Query: 499 K--DLIEKLKSAEEQITQLNDEIDAAN---KNMIKVKSNHKLKLKQMQKTIDN--FSKVS 551
+ +L ++L EQ+ Q + EI N K++ + K L+ ++++ I++ V
Sbjct: 963 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1022
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMI-----EM 605
+ ++ L + + ++ + AE K N +S M+E V ++ M +
Sbjct: 1023 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF---GEESKIMVEDKVSFENMTVGEESKQ 1079
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVC-SEIKSVH 663
E L L +++ S + E LQ++ + ++ + D+ Q+++ ++C S + S H
Sbjct: 1080 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1139
Query: 664 LEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL-- 720
+++ + + K K L + E L +E+ ++ + + M K Q E L
Sbjct: 1140 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHL 1198
Query: 721 -TDKLEKMSAEKISELL----AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
KL+K +E+ S L + + ++ + + K D EN + EL Y+
Sbjct: 1199 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1258
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMD 832
+ +E++ + ++ K L + L + +Q + E+ L +
Sbjct: 1259 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1318
Query: 833 -HDRVVEKQLLEIEHENK--ELQKKNQILLEEN--------QNLQISLSDMQQHYNALVE 881
H ++ + +++ H++K LQ + LEE +LQ L + +Q+Y A +
Sbjct: 1319 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIH 1378
Query: 882 KANRTDLAESESTKYQTQLRD----LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-- 935
+ A SEST + D ES+ +R + + KK I D IEF+ +
Sbjct: 1379 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCV----KKNI-DGTIEFSGEFG 1433
Query: 936 IESAIRDKKVLNEKYEKNIE 955
++ K+L ++Y++ +E
Sbjct: 1434 VKEETNIVKLLEKQYQEQLE 1453
Score = 51.6 bits (118), Expect = 2e-05
Identities = 281/1511 (18%), Positives = 594/1511 (39%), Gaps = 161/1511 (10%)
Query: 159 SVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQM 218
S+L+ + K +E +L + +++++++I + + ED KQQ
Sbjct: 790 SILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQC 848
Query: 219 TKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQEL 278
++ E EKQR K+ ++ E + + + LE SK QEL
Sbjct: 849 IQLNEEI---------EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 899
Query: 279 EQXXXXXXXXXXXXX-----XLAKQSIEPSCEEKT---------EIEEKGSLEIANMTEL 324
E K E+KT E+ EK + E+ E+
Sbjct: 900 EYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV 959
Query: 325 TK--KIEL---LEHLNCQIRQTNKE---LENKLATMGTESKAVSSPSKKGSPLISRKSGR 376
TK K+EL L L+ Q++Q + E L ++ ++ E + VS ++ +I+
Sbjct: 960 TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH---- 1015
Query: 377 NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
N A ++S +Q+SS D + E + +NK ++ ++ E
Sbjct: 1016 NRAENVQSCDTQVSSLL-----DGVVTMTSRGA-EGSVSKVNKSFGEESKIMVEDKVSFE 1069
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
G+++ QL L+H + S + T + +++ K LK E ND +
Sbjct: 1070 NMTV---GEESKQEQLILDHLPSVTKESSLRA-TQPSENDKLQKELNVLKSEQNDLRLQM 1125
Query: 497 NVKDLIEKLKSAEEQITQLNDEID-AANKNMIKVKSN----HKLKLKQMQKTIDNFSKVS 551
+ + L + + Q+ + ++ +K + +K + K+K++QK I +
Sbjct: 1126 EAQRICLSLVYSTH-VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQK-IHQLELQT 1183
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD------YDSGRMIESDVYKKMIEM 605
+E + LH L K+ + E+ + L + Y E + K
Sbjct: 1184 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1243
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ ++E + + D + +H L K E +KL + S + + LE
Sbjct: 1244 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1303
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI-MNKLQNYIQENMDLTDKL 724
+ L + E L I + + E + K + +D+ KL+ +QE L L
Sbjct: 1304 FGEENLPKEETEF-LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSL 1362
Query: 725 EKMSAEKISELLAKINHEEQSKIQ--TQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
++ E A+I H Q ++Q ++ + + + I +++ + Y C +
Sbjct: 1363 QQQLKETEQNYEAEI-HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CVKK 1420
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
+E +S E + + ++ +K Y E Q +E V ++ V M + +L
Sbjct: 1421 NIDGTIE---FSGEFGVKEETNIVKLLEKQYQE---QLEEEVAKVIVSMSIAFAQQTELS 1474
Query: 843 EIE--HENKELQKKNQILLEENQNL--QISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
I EN K+ + ++ Q+ ++ LS Q + D+ E +++
Sbjct: 1475 RISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF----ETVDVKFKE--EFKP 1528
Query: 899 QLRDLESNLKRI--THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
++L + K I ++ I + K + + E ++ ++ I + + +E +++
Sbjct: 1529 LSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDA 1588
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
QL ++ ++ + L +E + L H+++ + Q D EQ EI +LN
Sbjct: 1589 SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ-EQLQEEIKRLNR 1647
Query: 1017 LLKQK----DEEIIALNQKINNAQVSYMSMVS-----DYESKLAQFTTKLENMEEEMQRV 1067
L Q+ +E +++ +++ ++ + +S +L +T+ +N E V
Sbjct: 1648 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1707
Query: 1068 SKQL-----LDSKQHNEELQILVREQ------DDQIKELKETKLTFEMNIPKTEGMIISS 1116
+Q LD K + +IL E+ ++++ ++ + + +T G +
Sbjct: 1708 EEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLG 1767
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
++ S ++ V EE + + S+ + + ++K+
Sbjct: 1768 ILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVT 1827
Query: 1177 QLET-LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ T L+ L E + + + +++ + + E S SS ++
Sbjct: 1828 EEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQ 1887
Query: 1236 AELWKQHLAQRE--ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
EL ++ Q++ + K + ELR +L EQL +V+ S E E+ T
Sbjct: 1888 TELMRESFRQKQEATESLKCQEELRERLHEESRAREQL--AVELSKAEGVIDGYADEK-T 1944
Query: 1294 SLQNKLQDKEEHLRNLQEKYADVINQIEILRSE---IEDEKVAFXXXXXXXXXXXXXXXX 1350
+ ++Q+K + + L+++ N+++ L +E I++E+
Sbjct: 1945 LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ 2004
Query: 1351 DLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
L E + K M+E+ + E + +D + +V L +E
Sbjct: 2005 QLLQETE--KLMKEKLEVQCQAEKVR-------------------DDLQKQVKALEIDVE 2043
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ S + E +N E ++RQQ EK++E + + E AI R HE
Sbjct: 2044 EQVSRFIELEQE-------KNTELMDLRQQNQALEKQLEKMR-KFLDEQAIDR--EHERD 2093
Query: 1471 NHYETMQK-ESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
+ +QK E +++ V + ++ T ++V +L L+E+ K +E+ + E
Sbjct: 2094 VFQQEIQKLEQQLKVVPRFQPISEHQT------REVEQLANHLKEKTDKCSELLLSKEQL 2147
Query: 1530 EIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAEL 1589
+ +I N+EI L+ VR ++++ + ++DT Q ++++ + ++A P EL
Sbjct: 2148 QRDIQERNEEIEKLEFRVR----ELEQALLVSADTFQ----KVEDRKHFGAVEAKP--EL 2197
Query: 1590 DLAMYMLHQRD 1600
L + + +RD
Sbjct: 2198 SLEVQLQAERD 2208
>AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein.
Length = 1620
Score = 97.5 bits (232), Expect = 3e-19
Identities = 177/932 (18%), Positives = 402/932 (43%), Gaps = 85/932 (9%)
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E +D L+ E ++E+++ E + E+ E ++Q +A I++
Sbjct: 128 EQGAQDSPTHLEMMESELAGKQHEIEELNRE-LEEMRVTYGTEGLQQLQE---FEAAIKQ 183
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
RD I + + L + + + ++ L+ + QL + + +S
Sbjct: 184 RDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA- 242
Query: 820 EDELVNRLAVLMDHDRVVEKQ--LLEIEHENKE--------LQKKNQIL-LEENQNLQIS 868
+L+ ++ H + +E+Q LLE + KE LQ+K ++ +E+++ ++ S
Sbjct: 243 --DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENS 300
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ Q ++E+ N T + E E K +L+D + ++ E Q IVQK +EI+++
Sbjct: 301 NKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 357
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLE 987
++E + + + + + E + Q + ++ + + +L ++ E
Sbjct: 358 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 417
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQVSYMSM-VS 1044
L + + Q+ + Q++ ++ ++ K + E + N +N Q+ M++ ++
Sbjct: 418 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 477
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ KL ++ E ++EE+ + ++ ++ E+L + +QI+ ++T E
Sbjct: 478 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 537
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + + ST+E + + L+++ E E + L+ +
Sbjct: 538 KLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKIKLEMLEKEK 588
Query: 1165 NTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN--DNLLSTVA 1218
N L ++ +LE L T+L ++E++++LK LE ++N E DNL
Sbjct: 589 NAVLDRMAESQEAELERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 645
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKYEQL---LDS 1274
+ + + + Q+ E + K +L ++ +L+ +Q S SK E++ ++
Sbjct: 646 QQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 704
Query: 1275 VQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q QEE K ++V LQ K + E+ ++ + + Q+E S ++DE
Sbjct: 705 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 764
Query: 1331 KVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
K +++S + E+ I + EEN LK+
Sbjct: 765 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 824
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
+ AE K E+ +Q EL++ EY L ++D ++ +Q +EY+ ++
Sbjct: 825 EKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNKQELEYKSKL 874
Query: 1449 ----EDLTYEKESELAI-LRLKMHENANHY--ETMQKESEIER--VKLIEELNVKITESV 1499
E+L ++ + + ++ + + + ET++ +E+ +L+E+L V E +
Sbjct: 875 KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKL 934
Query: 1500 SLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L++++++L++ L+ EEV K + Q +L +E+EI+ ++ N+Q+
Sbjct: 935 ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCD 994
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
SS + V+ S +G +++ + +E
Sbjct: 995 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1026
Score = 88.6 bits (210), Expect = 2e-16
Identities = 177/942 (18%), Positives = 395/942 (41%), Gaps = 61/942 (6%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 452 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 510
Query: 207 XXXXXED---TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
E+ +++Q+ + ++ E++ +E + L +E I S E+ K LE
Sbjct: 511 LEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELEL- 568
Query: 264 RFEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIA 319
+ E + + K+ E+ E+ L + + + E+ + K LEI
Sbjct: 569 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 628
Query: 320 NMTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRN 377
+ + K K L H QI E+ K+ TM E + + + IS+ K +
Sbjct: 629 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 688
Query: 378 TASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
+ KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 689 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 748
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 749 EKFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEK 801
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 802 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLE 860
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 861 DSKNKQELEYKS-KLKALNEE---LHLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMG 912
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
++E +L+++L + +++ E+ +L+D+S+ Q Q EI L E++ +L K+
Sbjct: 913 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEIS--FLNEEVKSLKQEKE 969
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+++L L++ + +++++ + + L + +T + + S K+++
Sbjct: 970 QVSLRCRELEIIIN--HNRAENVQSCDTQVSSLLDGVV----TMTSRGAEGSVSKVNKSF 1023
Query: 737 ---AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+KI E++ + + + ++ L ++++ S + R + E+ + ++
Sbjct: 1024 GEESKIMVEDKVSFE-NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 1082
Query: 794 SLERKADQLGSYLQEKQKAYS-EYTIQEDELVNRLAVLMDHD--RVVEKQLLEIEHENKE 850
L+ + + L ++ ++ S Y+ D++ + D + E+ + E + KE
Sbjct: 1083 -LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1141
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE---------SESTKYQTQLR 901
LQK +Q+ L+ + + D + + L+ K + E S +Y T
Sbjct: 1142 LQKIHQLELQTMKTQE--TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1199
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
E N + + + + E++D E E+ + E+Y K + T+L
Sbjct: 1200 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL- 1258
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+++ + + L E L K E + H Q T D + ++++ L L K K
Sbjct: 1259 SKIWGQQTDGMKLEFGEENLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSLQDLEKTK 1316
Query: 1022 -DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
+E++ L I++ Q +YE+++ +L+ + E
Sbjct: 1317 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1358
Score = 65.7 bits (153), Expect = 1e-09
Identities = 130/687 (18%), Positives = 274/687 (39%), Gaps = 61/687 (8%)
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + +E I +T I + ++ + + ++E +++ + + + +
Sbjct: 46 MYINSSQRVESTVIPEST-IMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 104
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ NL L ++ + S + + + + L K EI LN+++ +
Sbjct: 105 VMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR 163
Query: 1037 VSY----MSMVSDYESKL-------AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
V+Y + + ++E+ + Q T L+ E ++ L+ + +++LQI
Sbjct: 164 VTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 223
Query: 1086 RE--QDDQIKELKETKLTFEMNIPKTEGMIISSTIEP----MSDDANNVDXXXXXXXXXX 1139
++ + ++ + ++ K + + +E + D +
Sbjct: 224 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 283
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+KV E E+ + + +E+ + T ++E TKII+ E EL + + +L
Sbjct: 284 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 343
Query: 1200 KSKLEQLNTENDNL---LSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADF-QKT 1253
+ ++ Q N E N+ L+ + S + Q + EL K++ +Q E D Q+
Sbjct: 344 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 403
Query: 1254 EHELRVQLSAFESKYEQLLDS--VQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNL- 1309
E E + +L ++ +++ VQ + + ME++ T + ++++ N+
Sbjct: 404 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 463
Query: 1310 ----QEKYADV-INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQM 1362
Q K +V IN++ I + +K L E S+ +
Sbjct: 464 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 523
Query: 1363 Q-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA-KVLELTHQLELKDSEI---- 1416
Q +++ I E+ ++L ++ V+ +E+ K LEL H+ E+ + +I
Sbjct: 524 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 583
Query: 1417 --YQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIEDLTYEKESELAILRLKMHENAN-H 1472
+K + E E +R QL+ +E+ + L + E E I K+ +N H
Sbjct: 584 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 643
Query: 1473 Y---------ETMQK--ESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEEVAKTN 1520
Y E QK + E+ LI + N I E L + Q + +N EE + N
Sbjct: 644 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 703
Query: 1521 EMQTALE---NQEIEIVTLNDEITNLQ 1544
E+Q +E +E E TL E+ LQ
Sbjct: 704 ELQKEIEILRQEEKEKGTLEQEVQELQ 730
Score = 52.4 bits (120), Expect = 1e-05
Identities = 158/800 (19%), Positives = 328/800 (41%), Gaps = 81/800 (10%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-LLEAARFEISLEHSK 273
KQQ+ +Q + EK L+ + IS L++ + L+ + E++L+ ++
Sbjct: 645 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 704
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
L +E+E +Q ++ + KTE+ EK E N +L +K LE
Sbjct: 705 LQKEIE-----ILRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKEN--DLQEKFAQLEA 756
Query: 334 LNCQIRQTNKELENKL---ATMGTESKAV--SSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
N ++ K LE+ L + E + + S K + K + + Q
Sbjct: 757 ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 816
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY--VISEKDTXXXXXXXXXXGKD 446
LN++ +K+ N A+ + N + +EY ++ KD
Sbjct: 817 CIQ--LNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDLEDSKNKQELEYK 871
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVN--------EIAKVQEQLKQELNDEIKDVNV 498
+ + L E P+ + + ++ D + E+ +V E+ EL ++++
Sbjct: 872 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 931
Query: 499 K--DLIEKLKSAEEQITQLNDEIDAAN---KNMIKVKSNHKLKLKQMQKTIDN--FSKVS 551
+ +L ++L EQ+ Q + EI N K++ + K L+ ++++ I++ V
Sbjct: 932 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 991
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMI-----EM 605
+ ++ L + + ++ + AE K N +S M+E V ++ M +
Sbjct: 992 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF---GEESKIMVEDKVSFENMTVGEESKQ 1048
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVC-SEIKSVH 663
E L L +++ S + E LQ++ + ++ + D+ Q+++ ++C S + S H
Sbjct: 1049 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1108
Query: 664 LEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL-- 720
+++ + + K K L + E L +E+ ++ + + M K Q E L
Sbjct: 1109 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHL 1167
Query: 721 -TDKLEKMSAEKISELL----AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
KL+K +E+ S L + + ++ + + K D EN + EL Y+
Sbjct: 1168 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1227
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMD 832
+ +E++ + ++ K L + L + +Q + E+ L +
Sbjct: 1228 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1287
Query: 833 -HDRVVEKQLLEIEHENK--ELQKKNQILLEEN--------QNLQISLSDMQQHYNALVE 881
H ++ + +++ H++K LQ + LEE +LQ L + +Q+Y A +
Sbjct: 1288 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIH 1347
Query: 882 KANRTDLAESESTKYQTQLRD----LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-- 935
+ A SEST + D ES+ +R + + KK I D IEF+ +
Sbjct: 1348 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCV----KKNI-DGTIEFSGEFG 1402
Query: 936 IESAIRDKKVLNEKYEKNIE 955
++ K+L ++Y++ +E
Sbjct: 1403 VKEETNIVKLLEKQYQEQLE 1422
>AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,
cardiac muscle, beta protein.
Length = 1983
Score = 96.3 bits (229), Expect = 8e-19
Identities = 206/1096 (18%), Positives = 452/1096 (41%), Gaps = 103/1096 (9%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
A+ ++E L ++ +++ E + LE I+ E + LA +L+
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 951
Query: 290 XXXXXLAKQSIE-----PSCEEKTEIEEKGSLEIA--------NMTELTKKIELLEHLNC 336
L K ++ E+ E EE+ + ++A TEL K I+ L+
Sbjct: 952 ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLA 1011
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
+ + + ENK+ + E A+ + L K A + Q + ++
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVAR---LTKEKKALQEAHQQALGDLQAEEDRVSA 1068
Query: 397 DTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
T K+ + ++ LE ++ K +D E +++ D + QLE
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTER--AKRKLEGDLKLTQESVADAAQDKQQLE 1126
Query: 456 HQQHMEGPSLIHVGTNTEDVNEI-AKVQEQLKQ------ELNDEIK-DVNVKDLIEKLKS 507
+ + L + ED + A++Q+++K+ EL +E++ + + +EK ++
Sbjct: 1127 EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRA 1186
Query: 508 AE----EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
E++++ +E A+ + + +L ++++ ++ + ++ +R
Sbjct: 1187 EAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1246
Query: 560 -----LTEELHHLSQKVAELEEEKGNLQLHLVDYDSG----RMIESDVYKKMIEMEN-LA 609
L E++ L + +LE+EK L++ + D + ++ K E+ L+
Sbjct: 1247 EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1306
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEV----EDKLADISQLQSDQVCSEIKSVHLE 665
E ++K + L+ Q D + LQ + E+ E+K ISQL + + L
Sbjct: 1307 EAKIK-VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKL 724
Q++ S +K LA ++ L+ D + L ++ ++ + +LQ + + N ++
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLL----REQHEEEAEAQAELQRLLSKANAEVAQWR 1421
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE-SELSKYKSRICRLEE 783
K A+ I EE + + + + + E + N + S L K K R+ E
Sbjct: 1422 SKYEADAIQRT------EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESE 1475
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ + +R S D+ +L+ +A E QE+E+ L R + +L
Sbjct: 1476 DVTLELERATSAAAALDKKQRHLE---RALEERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYN---ALVEKANRTDLA-ESESTKYQTQ 899
+ H ++E + + L EN+NLQ +SD+ + +++ +T A E E ++ Q
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-T 958
L + E L+ E +TL +Q E+ ++ E + ++ + L +++ +E +
Sbjct: 1593 LEEAEGALE--LEETKTLRIQ--LELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1648
Query: 959 QLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
L+A+ + +N L +E +LN + L+L H +Q T++ T ++ + A
Sbjct: 1649 SLDAETRA-RNEALRLKKKMEGDLNDLELQL--GHATRQATEAQAATRLMQAQLKEEQA- 1704
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ- 1076
+DEE L +++ + S ++L + LE E + ++LL++ +
Sbjct: 1705 --GRDEE-QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATER 1761
Query: 1077 ----HNEELQIL---------VREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPM 1121
H++ +L + + +++E + + E K T+ +++ ++
Sbjct: 1762 LNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1821
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
D + +++ L+ + EE ++Q KL +++E ++ +
Sbjct: 1822 QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKK 1881
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ E ++ ++ +L + E+ + V +L+S + S +R FE AE Q
Sbjct: 1882 HAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSY--KRQFEEAE---Q 1936
Query: 1242 HLAQREADFQKTEHEL 1257
A ++K +HEL
Sbjct: 1937 QANTNLAKYRKAQHEL 1952
Score = 87.0 bits (206), Expect = 5e-16
Identities = 194/1068 (18%), Positives = 420/1068 (39%), Gaps = 71/1068 (6%)
Query: 503 EKLKSAEEQITQ-LND---EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++L+ ITQ ND ++ A N+ + L +K + KV + ++ +
Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSK---VQLEGKVKELSERLE 976
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
E L+ + +LE+E L+ D D ++ + K+ EN + + ++
Sbjct: 977 DEEEVNADLAARRRKLEDECTELKK---DIDDLKLTLAKAEKEKQATENKVKNLTEEMAA 1033
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS-VHLEEQIDALSASKKE 677
L+ L +E LQ+ + + L D+ Q + D+V + K+ + LE+Q++ L S ++
Sbjct: 1034 LDESVARLTKEKKALQEAHQQA---LGDL-QAEEDRVSALTKAKLRLEQQVEDLECSLEQ 1089
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+ L++D E+ + LE D + + + Q+ L +KL+K +E +S+L
Sbjct: 1090 E----KKLRMDTERAK---RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE-LSQLSL 1141
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
++ E+ Q Q KI+E E +E EL ++ R+E+ A L
Sbjct: 1142 RVEDEQLLGAQMQ----KKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLA-VLMDHDRVVEKQLLEIEHENKELQKKNQ 856
+ ++ G +++ + + L L + H+ V + EL ++
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD 1257
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
L Q L+ S+++ + L A++ + K D S K E Q
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQR 1317
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN----IEYVTQLEAQLQEYKNNIE 972
+ + L+ E + ++ + +K+ L + + + + +L QL+E
Sbjct: 1318 QLADASTQRGRLQTE-SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKS 1376
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQK 1031
L V+ L L ++H ++ + Q+ ++ +++ N A + K E + I ++
Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEEAEAQAE--LQRLLSKANAEVAQWRSKYEADAIQRTEE 1434
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ A+ + + E + K ++E+ R+ + D E D +
Sbjct: 1435 LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
+ L+ E + E M +E ++ + ++ E
Sbjct: 1495 QRHLERA---LEERRRQEEEM--QRELEAAQRESRGLGTELFRLRHGHEEA-LEALETLK 1548
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
+E LQE+ + L ++ I +LE L G Q + + + LE T+
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYE 1269
+ ++++++ + + ++ E A L + H E+ + E R + A + K E
Sbjct: 1609 RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKME 1668
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSL-QNKL------QDKEEHL-RNLQEKYADVINQIE 1321
L+ ++ T + + T L Q +L +D+E+ L L E+ + +
Sbjct: 1669 GDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRAS 1728
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
+L +E+E+ + A L ++N +++ ++ + +
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSG 1788
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDE 1433
++++++ + DA EL + + E +KT E T+ L R +E
Sbjct: 1789 EVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1848
Query: 1434 FENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIE 1483
E ++Q+ + E ++ +L E ++E A+ ++ HE Q E + +
Sbjct: 1849 AEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRK 1908
Query: 1484 RVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
+ +++L K+ V S +Q E + +AK + Q L++ E
Sbjct: 1909 NLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAE 1956
Score = 80.2 bits (189), Expect = 6e-14
Identities = 173/972 (17%), Positives = 381/972 (39%), Gaps = 67/972 (6%)
Query: 659 IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY----- 713
++S EE++ AL A + L + + +++L T + +K D+ +LQ
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 714 -IQENMDLTDKLEKMSAEKISELLAKINHEEQ---------SKIQTQ-FGIDAKIQERDL 762
+E L K + K+ EL ++ EE+ K++ + + I + L
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
+ E E ++++ L E +A +++ S+ R + + + Q+A + +ED
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDE---SVARLTKEKKALQEAHQQALGDLQAEEDR 1065
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENK---ELQKKNQILLEENQNLQISLSDMQQHYNAL 879
+ + ++ VE +E E K + ++ + L + + Q S++D Q L
Sbjct: 1066 VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL 1125
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFNTQI 936
EK + D S+ + + L + +++ E Q + ++E+E Q
Sbjct: 1126 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR 1185
Query: 937 ESAIRDKKVLNEKYEK-------NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
A R+ + L+E+ E+ E + EA+L + +E + E L
Sbjct: 1186 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR-HEATVAALRRK 1244
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + D ++ ++ K + L+ + +++ A + + A+ S + YE +
Sbjct: 1245 QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ 1304
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
L++ K+E ++ ++ S Q + + EL L+ E++ I +L K ++ +
Sbjct: 1305 LSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEEL 1364
Query: 1110 EGMI---------ISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEEFIQERSVL 1157
+ ++ ++ + D + + L+ + E Q RS
Sbjct: 1365 RRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKY 1424
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
+ + + EL+E K + L E G + N + + K+KL +L TE+++ ++
Sbjct: 1425 EADAIQRTEELEEAKKK-LALRLQEAE-EGVEAANAKCSSLEKAKL-RLQTESED-VTLE 1480
Query: 1218 AELRSSISSAVD--QRGFEIA---ELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
E +S ++A+D QR E A ++ QRE + Q+ L +L +E+
Sbjct: 1481 LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEA 1540
Query: 1272 LDSVQSSTQEETN---KIVTMEQVTSLQNK-LQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L+++++ +E N +I + SL K +Q+ E+ + L+ + +++ +E +
Sbjct: 1541 LEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1600
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
E E+ L +++ ++ + A L +
Sbjct: 1601 ELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA 1660
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR---NDEFENVRQQLVEY 1444
D L+L H + +E T L + DE + + +L E
Sbjct: 1661 LRLKKKMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQ 1719
Query: 1445 EKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNV-KITESVSL 1501
+ +E +EL LR + + ++E ER+ L+ N + + L
Sbjct: 1720 AQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL 1779
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+A+L+ +EE + E + + + + +E+ Q+ A +++K +
Sbjct: 1780 EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKTLEQT 1838
Query: 1562 SDTKQGRDEQLD 1573
Q R E+ +
Sbjct: 1839 VRELQARLEEAE 1850
Score = 69.7 bits (163), Expect = 8e-11
Identities = 157/854 (18%), Positives = 346/854 (40%), Gaps = 77/854 (9%)
Query: 213 DTKQQMTKMQENF-IAME--AEWKDEKQRLLKDIESKDVRISSLE---EANKLLEAARFE 266
DT++ K++ + + E A+ +KQ+L + ++ KD +S L E +LL A +
Sbjct: 1096 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 1155
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
E A+ELE+ ++ E +EE G K
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
+ L L ++ + L ++ K ++ G + S + R K KS
Sbjct: 1216 REAELGRLRRELEEA--ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSEL 1273
Query: 387 SQ------LSSETLNQ---DTDK--KINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
+ ETL + +K + ++++++ ++ ++ L + L D T
Sbjct: 1274 RMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTES 1333
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLK----- 486
K+ LI+ QL + + SL + E+ ++ +A + L+
Sbjct: 1334 GELSRLLEEKECLIS--QLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 487 -QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDA----ANKNMIKVKSNHKLKLKQMQ 541
+E ++E + +L L A ++ Q + +A + + + K L+L++ +
Sbjct: 1392 LREQHEEEAEAQA-ELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE 1450
Query: 542 KTIDNF-SKVSDSNKEIVRL-------TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+ ++ +K S K +RL T EL + A L++++ +L+ L + R
Sbjct: 1451 EGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL---EERRR 1507
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
E ++ +++ + + + L + ++ L L+++ ++++++D+ +D
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDL----TD 1563
Query: 654 QVCSEIKSV-HLEEQIDALSASKKELALVIEN----LKLDKEQLYGTIKDLENDKEDIMN 708
QV KS+ LE+ AL K E+ +E L+L++ + +L K ++
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623
Query: 709 KLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE 768
KL +E +L + + + E + L ++ + ++ + + +L + +
Sbjct: 1624 KLAEKDEECANLR-RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHAT 1682
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ ++ ++ ++ + + R +R A +L Q ++ S + +EL L
Sbjct: 1683 RQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1742
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
R+ E++LLE L +N LL + + L+ +D+ Q + E A
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE---ADLAQLSGEVEEAAQERRE 1799
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE----SAIRDKK 944
AE ++ K T + LK+ + + + KK +E E ++E +A+R K
Sbjct: 1800 AEEKAKKAITDAAMMAEELKK-EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGK 1858
Query: 945 VLNEKYEKNI-EYVTQLEAQ----------LQEYKNNIENLNMNVEELNKMNLELIDKHV 993
+K E + E +L+A+ +++++ ++ L EE ++ NL + V
Sbjct: 1859 KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEE-DRKNLARMQDLV 1917
Query: 994 QKQQTQSPDYTEQY 1007
K Q++ Y Q+
Sbjct: 1918 DKLQSKVKSYKRQF 1931
Score = 57.2 bits (132), Expect = 5e-07
Identities = 138/704 (19%), Positives = 286/704 (40%), Gaps = 53/704 (7%)
Query: 233 KDEKQRLLKDIESK--DVRISSLEEANKLLEAA--RFEISLEHSKLAQELEQXXXXXXXX 288
K ++L + E + + +I E +L +A+ R + E +L++ LE+
Sbjct: 1291 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL 1350
Query: 289 XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELEN 347
LA QS+E + E E K +A+ + L +LL + + + EL+
Sbjct: 1351 SRGKA-LAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQR 1408
Query: 348 KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
L+ E SK + I R A K + Q + E + + + K + E
Sbjct: 1409 LLSKANAE--VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV-EAANAKCSSLEK 1465
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
AKL + +S + L + E S + Q + E Q+ +E
Sbjct: 1466 AKLRLQTESEDVTL-ELERATSAAAALDKKQRHLERALEERRRQEE-EMQRELEAAQRES 1523
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
G TE + + E+ + L + +K N K+L E++ +Q++ I K
Sbjct: 1524 RGLGTE-LFRLRHGHEEALEAL-ETLKREN-KNLQEEISDLTDQVSLSGKSIQELEKTK- 1579
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL--TEELHHLSQKVAELEEEKGNLQLHL 585
K K +++ + + ++ ++ ++L ++ + +K+AE +EE NL+ +
Sbjct: 1580 KALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRN- 1638
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETR-LKAISLLESQKFDLVQEL-HILQQKYDEVEDK 643
R +ES + ++ E A L+ +E DL +L H +Q +
Sbjct: 1639 ----HQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692
Query: 644 LADISQLQSDQVCSEIK---SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+QL+ +Q + + + L EQ AL LA +E L+ EQ + + E
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1752
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ + +L +N L ++ +K+ A+ +++L ++ Q + + + I +
Sbjct: 1753 QELLEATERLNLLHSQNTGLLNQKKKLEAD-LAQLSGEVEEAAQERREAEEKAKKAITDA 1811
Query: 761 DLYIENI--ESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY---- 813
+ E + E + S + R+ + LE+++ ++ R E+ A + G +K +A
Sbjct: 1812 AMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL 1871
Query: 814 -SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-------------- 858
+E ++ + L + H+R V++ + E + K L + ++
Sbjct: 1872 EAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 1931
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
E Q +L+ ++ + L + R D+AE+++ K + + RD
Sbjct: 1932 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
>AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,
cardiac muscle, beta protein.
Length = 1983
Score = 96.3 bits (229), Expect = 8e-19
Identities = 206/1096 (18%), Positives = 452/1096 (41%), Gaps = 103/1096 (9%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
A+ ++E L ++ +++ E + LE I+ E + LA +L+
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 951
Query: 290 XXXXXLAKQSIE-----PSCEEKTEIEEKGSLEIA--------NMTELTKKIELLEHLNC 336
L K ++ E+ E EE+ + ++A TEL K I+ L+
Sbjct: 952 ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLA 1011
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQ 396
+ + + ENK+ + E A+ + L K A + Q + ++
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVAR---LTKEKKALQEAHQQALGDLQAEEDRVSA 1068
Query: 397 DTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
T K+ + ++ LE ++ K +D E +++ D + QLE
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTER--AKRKLEGDLKLTQESVADAAQDKQQLE 1126
Query: 456 HQQHMEGPSLIHVGTNTEDVNEI-AKVQEQLKQ------ELNDEIK-DVNVKDLIEKLKS 507
+ + L + ED + A++Q+++K+ EL +E++ + + +EK ++
Sbjct: 1127 EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRA 1186
Query: 508 AE----EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR---- 559
E++++ +E A+ + + +L ++++ ++ + ++ +R
Sbjct: 1187 EAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1246
Query: 560 -----LTEELHHLSQKVAELEEEKGNLQLHLVDYDSG----RMIESDVYKKMIEMEN-LA 609
L E++ L + +LE+EK L++ + D + ++ K E+ L+
Sbjct: 1247 EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1306
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEV----EDKLADISQLQSDQVCSEIKSVHLE 665
E ++K + L+ Q D + LQ + E+ E+K ISQL + + L
Sbjct: 1307 EAKIK-VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKL 724
Q++ S +K LA ++ L+ D + L ++ ++ + +LQ + + N ++
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLL----REQHEEEAEAQAELQRLLSKANAEVAQWR 1421
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE-SELSKYKSRICRLEE 783
K A+ I EE + + + + + E + N + S L K K R+ E
Sbjct: 1422 SKYEADAIQRT------EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESE 1475
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ + +R S D+ +L+ +A E QE+E+ L R + +L
Sbjct: 1476 DVTLELERATSAAAALDKKQRHLE---RALEERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYN---ALVEKANRTDLA-ESESTKYQTQ 899
+ H ++E + + L EN+NLQ +SD+ + +++ +T A E E ++ Q
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-T 958
L + E L+ E +TL +Q E+ ++ E + ++ + L +++ +E +
Sbjct: 1593 LEEAEGALE--LEETKTLRIQ--LELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1648
Query: 959 QLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
L+A+ + +N L +E +LN + L+L H +Q T++ T ++ + A
Sbjct: 1649 SLDAETRA-RNEALRLKKKMEGDLNDLELQL--GHATRQATEAQAATRLMQAQLKEEQA- 1704
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ- 1076
+DEE L +++ + S ++L + LE E + ++LL++ +
Sbjct: 1705 --GRDEE-QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATER 1761
Query: 1077 ----HNEELQIL---------VREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPM 1121
H++ +L + + +++E + + E K T+ +++ ++
Sbjct: 1762 LNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1821
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
D + +++ L+ + EE ++Q KL +++E ++ +
Sbjct: 1822 QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKK 1881
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+ E ++ ++ +L + E+ + V +L+S + S +R FE AE Q
Sbjct: 1882 HAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSY--KRQFEEAE---Q 1936
Query: 1242 HLAQREADFQKTEHEL 1257
A ++K +HEL
Sbjct: 1937 QANTNLAKYRKAQHEL 1952
Score = 87.0 bits (206), Expect = 5e-16
Identities = 194/1068 (18%), Positives = 420/1068 (39%), Gaps = 71/1068 (6%)
Query: 503 EKLKSAEEQITQ-LND---EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV 558
++L+ ITQ ND ++ A N+ + L +K + KV + ++ +
Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSK---VQLEGKVKELSERLE 976
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
E L+ + +LE+E L+ D D ++ + K+ EN + + ++
Sbjct: 977 DEEEVNADLAARRRKLEDECTELKK---DIDDLKLTLAKAEKEKQATENKVKNLTEEMAA 1033
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS-VHLEEQIDALSASKKE 677
L+ L +E LQ+ + + L D+ Q + D+V + K+ + LE+Q++ L S ++
Sbjct: 1034 LDESVARLTKEKKALQEAHQQA---LGDL-QAEEDRVSALTKAKLRLEQQVEDLECSLEQ 1089
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+ L++D E+ + LE D + + + Q+ L +KL+K +E +S+L
Sbjct: 1090 E----KKLRMDTERAK---RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE-LSQLSL 1141
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
++ E+ Q Q KI+E E +E EL ++ R+E+ A L
Sbjct: 1142 RVEDEQLLGAQMQ----KKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLA-VLMDHDRVVEKQLLEIEHENKELQKKNQ 856
+ ++ G +++ + + L L + H+ V + EL ++
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD 1257
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
L Q L+ S+++ + L A++ + K D S K E Q
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQR 1317
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN----IEYVTQLEAQLQEYKNNIE 972
+ + L+ E + ++ + +K+ L + + + + +L QL+E
Sbjct: 1318 QLADASTQRGRLQTE-SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKS 1376
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQK 1031
L V+ L L ++H ++ + Q+ ++ +++ N A + K E + I ++
Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEEAEAQAE--LQRLLSKANAEVAQWRSKYEADAIQRTEE 1434
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ A+ + + E + K ++E+ R+ + D E D +
Sbjct: 1435 LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
+ L+ E + E M +E ++ + ++ E
Sbjct: 1495 QRHLERA---LEERRRQEEEM--QRELEAAQRESRGLGTELFRLRHGHEEA-LEALETLK 1548
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
+E LQE+ + L ++ I +LE L G Q + + + LE T+
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYE 1269
+ ++++++ + + ++ E A L + H E+ + E R + A + K E
Sbjct: 1609 RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKME 1668
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSL-QNKL------QDKEEHL-RNLQEKYADVINQIE 1321
L+ ++ T + + T L Q +L +D+E+ L L E+ + +
Sbjct: 1669 GDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRAS 1728
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXX------XXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
+L +E+E+ + A L ++N +++ ++ + +
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSG 1788
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDE 1433
++++++ + DA EL + + E +KT E T+ L R +E
Sbjct: 1789 EVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1848
Query: 1434 FENV-----RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIE 1483
E ++Q+ + E ++ +L E ++E A+ ++ HE Q E + +
Sbjct: 1849 AEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRK 1908
Query: 1484 RVKLIEELNVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
+ +++L K+ V S +Q E + +AK + Q L++ E
Sbjct: 1909 NLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAE 1956
Score = 80.2 bits (189), Expect = 6e-14
Identities = 173/972 (17%), Positives = 381/972 (39%), Gaps = 67/972 (6%)
Query: 659 IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY----- 713
++S EE++ AL A + L + + +++L T + +K D+ +LQ
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 714 -IQENMDLTDKLEKMSAEKISELLAKINHEEQ---------SKIQTQ-FGIDAKIQERDL 762
+E L K + K+ EL ++ EE+ K++ + + I + L
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
+ E E ++++ L E +A +++ S+ R + + + Q+A + +ED
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDE---SVARLTKEKKALQEAHQQALGDLQAEEDR 1065
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHENK---ELQKKNQILLEENQNLQISLSDMQQHYNAL 879
+ + ++ VE +E E K + ++ + L + + Q S++D Q L
Sbjct: 1066 VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQL 1125
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFNTQI 936
EK + D S+ + + L + +++ E Q + ++E+E Q
Sbjct: 1126 EEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR 1185
Query: 937 ESAIRDKKVLNEKYEK-------NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
A R+ + L+E+ E+ E + EA+L + +E + E L
Sbjct: 1186 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR-HEATVAALRRK 1244
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + D ++ ++ K + L+ + +++ A + + A+ S + YE +
Sbjct: 1245 QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ 1304
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT 1109
L++ K+E ++ ++ S Q + + EL L+ E++ I +L K ++ +
Sbjct: 1305 LSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEEL 1364
Query: 1110 EGMI---------ISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEEFIQERSVL 1157
+ ++ ++ + D + + L+ + E Q RS
Sbjct: 1365 RRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKY 1424
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
+ + + EL+E K + L E G + N + + K+KL +L TE+++ ++
Sbjct: 1425 EADAIQRTEELEEAKKK-LALRLQEAE-EGVEAANAKCSSLEKAKL-RLQTESED-VTLE 1480
Query: 1218 AELRSSISSAVD--QRGFEIA---ELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
E +S ++A+D QR E A ++ QRE + Q+ L +L +E+
Sbjct: 1481 LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEA 1540
Query: 1272 LDSVQSSTQEETN---KIVTMEQVTSLQNK-LQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L+++++ +E N +I + SL K +Q+ E+ + L+ + +++ +E +
Sbjct: 1541 LEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1600
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
E E+ L +++ ++ + A L +
Sbjct: 1601 ELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA 1660
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR---NDEFENVRQQLVEY 1444
D L+L H + +E T L + DE + + +L E
Sbjct: 1661 LRLKKKMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQ 1719
Query: 1445 EKRIEDLTYEKESELAILRLKMHENANHYETMQKE--SEIERVKLIEELNV-KITESVSL 1501
+ +E +EL LR + + ++E ER+ L+ N + + L
Sbjct: 1720 AQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL 1779
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+A+L+ +EE + E + + + + +E+ Q+ A +++K +
Sbjct: 1780 EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKTLEQT 1838
Query: 1562 SDTKQGRDEQLD 1573
Q R E+ +
Sbjct: 1839 VRELQARLEEAE 1850
Score = 69.7 bits (163), Expect = 8e-11
Identities = 157/854 (18%), Positives = 346/854 (40%), Gaps = 77/854 (9%)
Query: 213 DTKQQMTKMQENF-IAME--AEWKDEKQRLLKDIESKDVRISSLE---EANKLLEAARFE 266
DT++ K++ + + E A+ +KQ+L + ++ KD +S L E +LL A +
Sbjct: 1096 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 1155
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
E A+ELE+ ++ E +EE G K
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPW 386
+ L L ++ + L ++ K ++ G + S + R K KS
Sbjct: 1216 REAELGRLRRELEEA--ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSEL 1273
Query: 387 SQ------LSSETLNQ---DTDK--KINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
+ ETL + +K + ++++++ ++ ++ L + L D T
Sbjct: 1274 RMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTES 1333
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLK----- 486
K+ LI+ QL + + SL + E+ ++ +A + L+
Sbjct: 1334 GELSRLLEEKECLIS--QLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 487 -QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDA----ANKNMIKVKSNHKLKLKQMQ 541
+E ++E + +L L A ++ Q + +A + + + K L+L++ +
Sbjct: 1392 LREQHEEEAEAQA-ELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE 1450
Query: 542 KTIDNF-SKVSDSNKEIVRL-------TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+ ++ +K S K +RL T EL + A L++++ +L+ L + R
Sbjct: 1451 EGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL---EERRR 1507
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
E ++ +++ + + + L + ++ L L+++ ++++++D+ +D
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDL----TD 1563
Query: 654 QVCSEIKSV-HLEEQIDALSASKKELALVIEN----LKLDKEQLYGTIKDLENDKEDIMN 708
QV KS+ LE+ AL K E+ +E L+L++ + +L K ++
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623
Query: 709 KLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE 768
KL +E +L + + + E + L ++ + ++ + + +L + +
Sbjct: 1624 KLAEKDEECANLR-RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHAT 1682
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ ++ ++ ++ + + R +R A +L Q ++ S + +EL L
Sbjct: 1683 RQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1742
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
R+ E++LLE L +N LL + + L+ +D+ Q + E A
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE---ADLAQLSGEVEEAAQERRE 1799
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE----SAIRDKK 944
AE ++ K T + LK+ + + + KK +E E ++E +A+R K
Sbjct: 1800 AEEKAKKAITDAAMMAEELKK-EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGK 1858
Query: 945 VLNEKYEKNI-EYVTQLEAQ----------LQEYKNNIENLNMNVEELNKMNLELIDKHV 993
+K E + E +L+A+ +++++ ++ L EE ++ NL + V
Sbjct: 1859 KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEE-DRKNLARMQDLV 1917
Query: 994 QKQQTQSPDYTEQY 1007
K Q++ Y Q+
Sbjct: 1918 DKLQSKVKSYKRQF 1931
Score = 57.2 bits (132), Expect = 5e-07
Identities = 138/704 (19%), Positives = 286/704 (40%), Gaps = 53/704 (7%)
Query: 233 KDEKQRLLKDIESK--DVRISSLEEANKLLEAA--RFEISLEHSKLAQELEQXXXXXXXX 288
K ++L + E + + +I E +L +A+ R + E +L++ LE+
Sbjct: 1291 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL 1350
Query: 289 XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELEN 347
LA QS+E + E E K +A+ + L +LL + + + EL+
Sbjct: 1351 SRGKA-LAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQR 1408
Query: 348 KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
L+ E SK + I R A K + Q + E + + + K + E
Sbjct: 1409 LLSKANAE--VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV-EAANAKCSSLEK 1465
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
AKL + +S + L + E S + Q + E Q+ +E
Sbjct: 1466 AKLRLQTESEDVTL-ELERATSAAAALDKKQRHLERALEERRRQEE-EMQRELEAAQRES 1523
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
G TE + + E+ + L + +K N K+L E++ +Q++ I K
Sbjct: 1524 RGLGTE-LFRLRHGHEEALEAL-ETLKREN-KNLQEEISDLTDQVSLSGKSIQELEKTK- 1579
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL--TEELHHLSQKVAELEEEKGNLQLHL 585
K K +++ + + ++ ++ ++L ++ + +K+AE +EE NL+ +
Sbjct: 1580 KALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRN- 1638
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETR-LKAISLLESQKFDLVQEL-HILQQKYDEVEDK 643
R +ES + ++ E A L+ +E DL +L H +Q +
Sbjct: 1639 ----HQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692
Query: 644 LADISQLQSDQVCSEIK---SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+QL+ +Q + + + L EQ AL LA +E L+ EQ + + E
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1752
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ + +L +N L ++ +K+ A+ +++L ++ Q + + + I +
Sbjct: 1753 QELLEATERLNLLHSQNTGLLNQKKKLEAD-LAQLSGEVEEAAQERREAEEKAKKAITDA 1811
Query: 761 DLYIENI--ESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY---- 813
+ E + E + S + R+ + LE+++ ++ R E+ A + G +K +A
Sbjct: 1812 AMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL 1871
Query: 814 -SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-------------- 858
+E ++ + L + H+R V++ + E + K L + ++
Sbjct: 1872 EAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 1931
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
E Q +L+ ++ + L + R D+AE+++ K + + RD
Sbjct: 1932 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
>Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein.
Length = 2115
Score = 95.9 bits (228), Expect = 1e-18
Identities = 248/1399 (17%), Positives = 551/1399 (39%), Gaps = 100/1399 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ + + ++ E EW +++ +L K++ + LEE N++L+ ++ EH
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE-EH 393
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELL 331
Q+ KQ T+++ + +E+ ++ +LL
Sbjct: 394 LSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR--VEMLETERGQQEAKLL 451
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ ++L + + + + +S +K+ S+ G +++ S S+L+
Sbjct: 452 AERG-HFEEEKQQLSSLITDLQSSISNLSQ-AKEELEQASQAHGARLTAQVASLTSELT- 508
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQ 451
TLN ++ E+A L+ + L + +++ + L +
Sbjct: 509 -TLNATIQQQ--DQELAGLKQQAKEKQAQLAQ---TLQQQEQASQGLRHQV---EQLSSS 559
Query: 452 LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA--- 508
L+ + QQ E T + ++A E+ + L + + + +EK K+A
Sbjct: 560 LKQKEQQLKEVAEK-QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
Query: 509 --EEQITQLNDEIDAANKNMIKV---KSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLTE 562
++Q+ N+ D+A ++ + K+ K++++Q ++ + ++ ++ L
Sbjct: 619 ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
Query: 563 ELHHLSQKVAELE---EEKGNLQLHLVDY-DSGRMIESDVYKKMIEMENLAETRLKAISL 618
+L QK E E +EK LQ L +S ++ + + ++ + E + + IS
Sbjct: 679 QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE 738
Query: 619 LESQKFDLVQELHILQQKYDEVE-----DKLADISQL-QSDQVCSEIKSVHLEEQIDALS 672
L+++ LV++ H ++K E E A + QL ++ Q +E+ L E + A
Sbjct: 739 LKAETRSLVEQ-HKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLEN----DKEDIMNKLQNYIQENMDLTDKLEKMS 728
++ E +++ + +E+ + ++ +E +M + + +L + EK++
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 729 A-EKISELLAKINHEEQSKIQTQFG-IDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
E SEL E +++ ++QE+++ + + +LS + ++ + +A
Sbjct: 858 GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVA 917
Query: 787 VMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
+E R + E++ ++E +A +E R ++ E E
Sbjct: 918 RLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR--QFCSTQAALQAMEREAE 975
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR--TDLAESESTKYQTQLRDL 903
EL++ L+E Q ++ L ++ R DLA ++ + + ++R L
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-L 1034
Query: 904 ESNLKRITHEHQTL-----IVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEKNIEYV 957
++ L E TL +KE +D E+ +E+A I++ + L + ++ E +
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
Query: 958 TQLEAQ-------LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
+ E + E E +E L + + +++ QKQQ Q+ D E+ + E
Sbjct: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEAL-RAEVSKLEQQCQKQQEQA-DSLERSL-E 1151
Query: 1011 INKLNALLKQKDEEII--ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
+ + + E + L +K S S ++ + +LA F TK+++ +
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHS-QSALASAQRELAAFRTKVQDHSKAEDEWK 1210
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII--SSTIEPMSDDAN 1126
Q+ +Q E L+ ++++ L L E + + +++ S + + +
Sbjct: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
+ EE R ++Q QE ++ + E L EL
Sbjct: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
QE+ Q + L L E+ + + V+EL + Q E A K+H +
Sbjct: 1331 AW----QEKFFQKEQALSTLQLEHTSTQALVSELLPA-KHLCQQLQAEQAAAEKRHREEL 1385
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE-------TNKIVTMEQVTSLQNKL 1299
E ++ LR +L + + +L+ Q ++E K EQ++ L+
Sbjct: 1386 EQS-KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
Query: 1300 QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
E R L E+ A++ Q L E++ + + +++ E QS
Sbjct: 1445 GLLAEENRGLGER-ANLGRQ--FLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS- 1500
Query: 1360 KQMQEQSILNINEENAQLK--KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE-----LK 1412
+E ++ E A++K + +V E E T Q+E L
Sbjct: 1501 -TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
Query: 1413 DSEIYQKTHEYTITLTQ-RNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
DS+ K + + Q + E + Q+L ++ +KE +L+M +
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
Query: 1472 HYETMQKESE--IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
HY+ +++++ E+++ +E+L E+ L + L L++ KT E + +
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQ---KENKELRAEAERLGHELQQAGLKTKEAEQTCRHL 1676
Query: 1530 EIEIVTLNDEITNLQNMVR 1548
++ +L ++ + +R
Sbjct: 1677 TAQVRSLEAQVAHADQQLR 1695
Score = 93.5 bits (222), Expect = 6e-18
Identities = 267/1445 (18%), Positives = 571/1445 (39%), Gaps = 117/1445 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDI-----ESKDVRISSLEEANKL--LEAARF 265
D + +T + + K EK ++ + I E+ D+ E A+ L L+ A
Sbjct: 283 DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALN 342
Query: 266 EISLEHSKLAQE-LEQXXXXXXXXXXXXXX---------LAKQSIEPSCEEKTEIEEKGS 315
E++ EHSK QE LE+ + + + E +++++
Sbjct: 343 ELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402
Query: 316 LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTE--SKAVSSPSKKGSPLISRK 373
E + ++E L+ + N +L+ ++ + TE + +++G ++
Sbjct: 403 QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 462
Query: 374 SGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDT 433
+ + ++S S LS ++ ++ ++ A+L + SL +L I ++D
Sbjct: 463 QLSSLITDLQSSISNLSQA---KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQ 519
Query: 434 XXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI 493
K +AQ + +Q +G L H E ++ K +EQ +E+ ++
Sbjct: 520 ELAGLKQQAKEKQAQLAQTLQQQEQASQG--LRH---QVEQLSSSLKQKEQQLKEVAEK- 573
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
++ +D ++L +A E+ E DAA K + ++ KL+ +Q+ + ++ DS
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 554 NK-EIVRLTEELHHLSQKVAELEE--EKGNLQLHLVDYDSGRM---IESDVYKKMIEMEN 607
+ + + E LS+KV EL+ E + H + + S+ +K E E
Sbjct: 634 AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE-QQKATEKER 692
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC-SEIKSVHLEE 666
+A+ + L+ Q L + L + + +E + + AD L+ Q C SE+K+
Sbjct: 693 VAQEK----DQLQEQLQALKESLKVTKGSLEEEKRRAADA--LEEQQRCISELKA-ETRS 745
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
++ +KEL E + ++ L ++ L + L+ + E M E
Sbjct: 746 LVEQHKRERKEL----EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 801
Query: 727 MSAEKISELLA-KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
+ + E+ A + +E+ + + Q+G A QE+ + ++ E K + + +E +
Sbjct: 802 ECEQLVKEVAAWRERYEDSQQEEAQYG--AMFQEQ---LMTLKEECEKARQELQEAKEKV 856
Query: 786 AVMEDR-RYSLERKADQLGSY---LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQL 841
A +E + R+ ++L L + E ++ +L + L+ L + K++
Sbjct: 857 AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR----TDLA----ESES 893
+E ++ ++ + E D Q + L E+ R T A E E+
Sbjct: 917 ARLETLVRKAGEQQETASRELVKEPARAGDRQPEW--LEEQQGRQFCSTQAALQAMEREA 974
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
+ +L L + L + Q Q+++E+ L E + ++ + +K + E
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE-RGRAQADLALEKAARAELEMR 1033
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
++ L Q E+ E L + E + EL ++ + E+ + +
Sbjct: 1034 LQ--NALNEQRVEFATLQEALAHALTEKEGKDQELAK--LRGLEAAQIKELEELRQTVKQ 1089
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
L L +K++E + + AQ KL ++ +E++ Q+ +Q D
Sbjct: 1090 LKEQLAKKEKE----HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQA-D 1144
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
S + + E + R + D E + +L + + ++ + S+ E + D
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1204
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
+ ++E E ++ S++ + L E+ ++++ E + EL +
Sbjct: 1205 AEDEWKAQVARGRQEAE--RKNSLI----SSLEEEVSILNRQVLEKEGESKELKRLVMAE 1258
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD--QRGFEIAELWKQHLAQREADF 1250
E+ +L+ +L L E + + AE S++ V + E + ++L Q
Sbjct: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ 1318
Query: 1251 QKTEHELRVQLSAFESKY---EQLLDSVQ---SSTQEETNKIVTMEQVTS-LQNKLQDKE 1303
+ EL +L A++ K+ EQ L ++Q +STQ ++++ + + LQ + E
Sbjct: 1319 AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE 1378
Query: 1304 E-HLRNL-QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
+ H L Q K A + E+LR++ E + LR E SY +
Sbjct: 1379 KRHREELEQSKQAAGGLRAELLRAQRE---LGELIPLRQKVAEQERTAQQLRAEKASYAE 1435
Query: 1362 ---MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH-QLELKDSEIY 1417
M +++ + EEN L + + + + + L E + +E+
Sbjct: 1436 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1495
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
++ L ++E + +++E +R +++E R K+ E Q
Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQR-----FQEE------RQKLTAQVEQLEVFQ 1544
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLN 1537
+E + K +EEL+ K+ +S +K + KA++ + ++ + L+ Q E+
Sbjct: 1545 RE----QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 1538 DEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+ + K + H Q EQL + + + RAE + + L
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ 1660
Query: 1598 QRDVR 1602
Q ++
Sbjct: 1661 QAGLK 1665
Score = 87.0 bits (206), Expect = 5e-16
Identities = 178/901 (19%), Positives = 352/901 (39%), Gaps = 85/901 (9%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEK---ISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
M +L+ + + D+LE AE ++E A+I +Q +I ++ K L
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQ-RIDRLALLNEKQAASPLE 274
Query: 764 IENIESELSKYKSRICRLEESIAVMED---RRYSLERKADQLGSY---LQEKQKAYSEYT 817
+ +E K +S RL E++ +D + ++RK +QL L K + ++ +
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQ 874
Q + +N L +H + ++ L + KEL + + L E+N+ LQ LS +++
Sbjct: 335 QQLQDALNELTE--EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
H + L + + + E QL L+ + + Q + +E LE E
Sbjct: 393 HLSQLQDNPPQE---KGEVLGDVLQLETLKQEAATLAANN----TQLQARVEMLETERGQ 445
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q + ++ E+ + QL + + + +++I NL+ EEL + + H
Sbjct: 446 QEAKLLAERGHFEEEKQ-------QLSSLITDLQSSISNLSQAKEELEQAS----QAHGA 494
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES------ 1048
+ Q T +E+ LNA ++Q+D+E+ L Q+ Q + E
Sbjct: 495 RLTAQVASLT----SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR 550
Query: 1049 -KLAQFTTKLENMEEEMQRVS-KQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
++ Q ++ L+ E++++ V+ KQ + H ++L E++ ++E LK+ +
Sbjct: 551 HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALE 610
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI----QERSVLQ 1158
+ K E + + + D+ KV+E + + QE+ Q
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
Q A+L +L+ K + E + E D + QEQ+ LK L+ + A
Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQE---KDQL-QEQLQALKESLKVTKGSLEEEKRRAA 726
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
+ + + E L +QH +R K E R E++ +QL ++ Q+
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRER-----KELEEERAGRKGLEARLQQLGEAHQAE 781
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
T+ V ++ E L ++ A + E + E F
Sbjct: 782 TE------VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQL 835
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+L+ + ++ S L I+ + +L + +V +
Sbjct: 836 MTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAE----LHANLARALQQVQEK 891
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYT--ITLTQR-NDEFENVRQQLVEYEKRIEDLTYEK 1455
E + +L L ++ + E TL ++ ++ E ++LV+ R D E
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
E + + A + M++E+E + +E L + ES Q E E E
Sbjct: 952 LEEQQGRQFCSTQAA--LQAMEREAE-QMGNELERLRAALMES---QGQQQEERGQQERE 1005
Query: 1516 VAKTNE----MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQ 1571
VA+ + Q L ++ L + N N R + +Q+ ++ A K+G+D++
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
Query: 1572 L 1572
L
Sbjct: 1066 L 1066
Score = 79.0 bits (186), Expect = 1e-13
Identities = 190/1010 (18%), Positives = 413/1010 (40%), Gaps = 86/1010 (8%)
Query: 638 DEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA-SKKELALVIENLKL----DKEQ- 691
DE+E +LA+ +L +++ + + ++++ID L+ ++K+ A +E +L DK +
Sbjct: 231 DELELELAENRKLLTEK---DAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNES 287
Query: 692 ----LYGTIK---DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH--E 742
L+ T+K DL+ +K + K+ +EN DL+ KL + A + +L +N E
Sbjct: 288 LTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREF-ASHLQQLQDALNELTE 346
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELS-KYKSRICRLEESIAVMEDRRYSLERKADQ 801
E SK TQ ++ + Q +E ELS + + C LEE +++ + LE Q
Sbjct: 347 EHSK-ATQEWLEKQAQ--------LEKELSAALQDKKC-LEEKNEILQGKLSQLEEHLSQ 396
Query: 802 L-GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK--QLLEIEHENKE--LQKKNQ 856
L + QEK + + +Q + L A L ++ ++ ++LE E +E L +
Sbjct: 397 LQDNPPQEKGEVLGD-VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Query: 857 ILLEENQNLQISLSDMQQHYNALVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
EE Q L ++D+Q + L + K +++ + Q+ L S L +
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL----N 511
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
I Q+ +E+ L+ + A + L + ++ + L Q+++ ++++
Sbjct: 512 ATIQQQDQELAGLK-------QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE----INKLNALLKQKDEEIIALNQK 1031
++E+ + H Q+ T + + E + E + +L AL K+K ++ L Q+
Sbjct: 565 QQLKEVAEKQEATRQDHAQQLATAAEE-REASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 1032 I---NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ N A+ S + V+ + + A+ + K+E ++ ++ ++ +++ EL++ +R +
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683
Query: 1089 DDQIKELKETKLTFEMNIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ E + + + + + + T + ++ LK +
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
Query: 1147 E---EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
E+ +ER L+E+ A L+ ++ + TE V + ++ + +
Sbjct: 744 RSLVEQHKRERKELEEERAG-RKGLEARLQQLGEAHQAETE------VLRRELAEAMAAQ 796
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL---RVQ 1260
+E + L+ VA R + Q + ++++ L + + +K EL + +
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDS-QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK 855
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
++ ES E + Q+ E N ++QV + + Q + L LQEK A
Sbjct: 856 VAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 915
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA- 1375
+ ++E L + +++ + E Q + Q+ L E A
Sbjct: 916 VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Query: 1376 ----QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI-YQKTHEYTITLTQR 1430
+L++ E +V LT + +++ +K + + +
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
N E + E LT ++ + + +L+ E A E + ++++K E+
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLK--EQ 1093
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L K E S + +E E K ++ + E + ++ +L+ + A
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
Query: 1551 SSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
+ + S A +T QG+ E+ + A+ A+ +LA + +D
Sbjct: 1154 RASRAERDS-ALETLQGQLEEKAQELGHS-QSALASAQRELAAFRTKVQD 1201
Score = 62.5 bits (145), Expect = 1e-08
Identities = 103/535 (19%), Positives = 226/535 (42%), Gaps = 44/535 (8%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQI-------LVREQDDQIKELKE--TKLTFEMNIP 1107
L+ + +M+R+ KQL D + + +EL++ L+ E+D QI +++ +L +N
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL-LNEK 267
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
+ + +E + D ++ LK E+ + ++ + L E++ L+ +
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFK 326
Query: 1168 LQECYTKIIQLETLNTELT-GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISS 1226
L+E + + QL+ ELT H QE + K QL E LS + + +
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWL----EKQAQLEKE----LSAALQDKKCLEE 378
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN-K 1285
+ ++++L ++HL+Q + + + + E+ + E+ ++ ++TQ + +
Sbjct: 379 KNEILQGKLSQL-EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
Query: 1286 IVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
++ E+ L ++ EE + L D+ + I L E+ + A
Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNI----NEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+L T N + +Q Q+Q + + E+ AQL ++ +V
Sbjct: 498 AQVASLTSELTTLNATIQQ-QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQL 556
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ + + QL+ + ++ L +E E ++ K++E L EK ++
Sbjct: 557 SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAK 616
Query: 1459 LAILRLKM---HENANHYETMQKESEIERVKL---IEELNVKI----TESVSLNKQVAEL 1508
L IL+ ++ +E + +T +++ E+ +L +EEL + E QVAEL
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL 676
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
L E K E + + ++ L +++ L+ ++ + +++ A+D
Sbjct: 677 ELQLRSEQQKATEKERVAQEKD----QLQEQLQALKESLKVTKGSLEEEKRRAAD 727
>BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein.
Length = 887
Score = 95.9 bits (228), Expect = 1e-18
Identities = 139/635 (21%), Positives = 291/635 (45%), Gaps = 61/635 (9%)
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
AK++ +L+QEL + K + D ++L+ E ++ +L E N N++ + ++
Sbjct: 255 AKIR-RLRQELEE--KTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRD 307
Query: 539 QMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL------HLVDYDSGR 592
++ + +V E+ R E LH + A +EE K + Q+ L D G
Sbjct: 308 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 367
Query: 593 MIESDVYKKMIEMENLA-ETRLKAISL---LESQKFDLVQE----LHILQ-QKYDEVEDK 643
SD ++ E ENL + +L + + ++ +K + + E L + Q Q DE
Sbjct: 368 RARSDKLHEL-EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 426
Query: 644 LADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK--EQLYGTIKDLEN 701
++ Q+ SE L +++ L++S+ L L +EN L K E+L T+ +E
Sbjct: 427 GWELEQISRTSELSEAPQKSLGHEVNELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEG 485
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK------IQTQFGIDA 755
+ I+ K++ +EN L+ K+E + E + E + N + SK Q + I+
Sbjct: 486 NASKIL-KME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 541
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYS-LERKADQLGSYLQEKQKAYS 814
+ + I+ +E E + L + + + R +E++ L ++E S
Sbjct: 542 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 601
Query: 815 EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ- 873
+ ++ ++ L +H + ++ E+E+E L+K+N++L ++ NL+I+ ++
Sbjct: 602 KIEFEKRQIKKEL----EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 657
Query: 874 -QHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTLI--VQKKK----EI 925
+ N+ +E+ NR +S K T QL LE ++ E+ L V+ K ++
Sbjct: 658 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 717
Query: 926 EDLEIEFNTQIESAIRDKK----VLNEKYEKN--IEYVTQ-LEAQLQEYKNNIENLNMNV 978
L++E N ++ES K +L ++K +E Q L+ + Q + +EN N +
Sbjct: 718 AQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 776
Query: 979 EELNK--MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
++L +LE+ ++ +QK + + + + ++ K N L+Q+ ++ +++
Sbjct: 777 QQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 835
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
++ L + K+ N+E+E + +SK++
Sbjct: 836 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 870
Score = 94.3 bits (224), Expect = 3e-18
Identities = 163/804 (20%), Positives = 353/804 (43%), Gaps = 58/804 (7%)
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE-EQITQLNDE 518
M P+++ +G N +V++ L L ++ ++ IE+++ + + +
Sbjct: 97 MSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH 156
Query: 519 IDAANKNMIKVKSNHKLKLKQM-QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
I N V +++ M Q+ I+ K + + RL +E S+ + EL EE
Sbjct: 157 IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLK--NMALHLKRLIDERDEHSETIIELSEE 214
Query: 578 KGNLQ-LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQK 636
+ L L + S K+ ++L+ A + + + +L ++ L
Sbjct: 215 RDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 274
Query: 637 YDEVEDKLADISQLQSDQV--CSEIKSVHL-EEQIDALSASKKELALVIENLKLDKEQLY 693
E+E ++ +LQ + + S+ +S + +++DAL +E A+ ++ L+ + +
Sbjct: 275 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL----REKAVRVDKLESEVSRYK 330
Query: 694 GTIKDLENDK---EDIMNKLQNYIQENMDLTDKLE--KMSAEKISELLAKINHEEQSKI- 747
+ D+E K E++ Q ++ L D+LE + ++K+ EL K N + ++K+
Sbjct: 331 ERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL-EKENLQLKAKLH 389
Query: 748 --QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ--LG 803
+ + +D K E +L EN+ E+++ +S L + + R S +A Q LG
Sbjct: 390 DMEMERDMDRKKIE-ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 448
Query: 804 SYLQEKQKAYSEYTIQEDE----LVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
+ E + E++ V L +D ++L++E EN+ L KK +IL
Sbjct: 449 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 508
Query: 860 EENQNLQISLSDMQQHYNALV-EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
E + SL + Q L+ EKA E+ + Q++ LE + H +QT+
Sbjct: 509 NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE---HLNQTVS 565
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
+++ +I +++ ++ K+L+E ++ ++++E + ++ K +E+
Sbjct: 566 SLRQRS----QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 621
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
E ++ EL H++K+ K+ AL +Q++ E+ N+K+ S
Sbjct: 622 ERAEELENEL--HHLEKENELLQKKITNLKITCEKIEAL-EQENSELERENRKLKKTLDS 678
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
+ ++ ES L + ++L+ E++R + L + +LQ+ +E + + ++LK+
Sbjct: 679 FKNLTFQLES-LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 737
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ 1158
+ + KTE + +S +++ K+Q+ E +Q+ +
Sbjct: 738 LELLKASFKKTERLEVSY-------QGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 790
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
+ K EL+ ++ QLE N L +++ +QL+ +QL EN L A
Sbjct: 791 QTLQKNLEELKISSKRLEQLEKENKSL-------EQETSQLEKDKKQLEKENKRLRQQ-A 842
Query: 1219 ELRSSISSAVDQRGFEIAELWKQH 1242
E++ + +++ +I L K++
Sbjct: 843 EIK---DTTLEENNVKIGNLEKEN 863
Score = 84.2 bits (199), Expect = 3e-15
Identities = 139/695 (20%), Positives = 285/695 (41%), Gaps = 51/695 (7%)
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+Q I+ ++ L+++ + E ++ I L E + ++ GS +
Sbjct: 179 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 238
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ ++ +++ + ++ L +QLL+ + E ++++ + + L +EN NL
Sbjct: 239 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 298
Query: 869 LSDMQQH---YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ + +AL EKA R D ESE ++Y+ +L D+E R V++ KE
Sbjct: 299 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR---------VEELKED 349
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL--NK 983
+ +E T +E + + ++K + + QL+A+L + + + +EEL
Sbjct: 350 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 409
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL-NQKINNAQVSYMSM 1042
M LE+ K + EQ A K E+ L + ++ ++ S+
Sbjct: 410 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 469
Query: 1043 VSDYE------SKLAQFTTKLENMEEEMQRVSK--QLLDSK--QHNEELQILVREQDDQI 1092
E + +K+ ME+E QR+SK ++L+++ Q + LQ D +
Sbjct: 470 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 529
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
KE + + T E +E I +E ++ N +V++ E +
Sbjct: 530 KEKAQLEKTIETLRENSERQI--KILEQENEHLNQTVSSLRQRSQISAEARVKDIE---K 584
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E +L E + +++L + + + EL H E+ +L+++L L EN+
Sbjct: 585 ENKILHESIKETSSKLSKIE---FEKRQIKKELE-HYKEKGERAEELENELHHLEKENEL 640
Query: 1213 LLSTVAELRSSIS--SAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
L + L+ + A++Q E+ E + L + F+ L QL + E + Q
Sbjct: 641 LQKKITNLKITCEKIEALEQENSEL-ERENRKLKKTLDSFK----NLTFQLESLEKENSQ 695
Query: 1271 L-LDSVQSSTQEETNKIVTMEQV-TSLQNK-LQDKEEHLRNLQEKYADVINQIEILR--- 1324
L ++++ E+ K +M+ L+NK L+ ++E L+ E + E L
Sbjct: 696 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSY 755
Query: 1325 --SEIEDEKV-AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+IE++++ DL ENQ+ ++ E+ ++ ++ QL+K +
Sbjct: 756 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKEN 814
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
E + L Q E+KD+ +
Sbjct: 815 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 849
Score = 75.8 bits (178), Expect = 1e-12
Identities = 127/545 (23%), Positives = 235/545 (43%), Gaps = 54/545 (9%)
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQ 276
++ ++++ + ++A+ D + +D++ K +I L E N LE A+ + E L
Sbjct: 373 KLHELEKENLQLKAKLHDMEME--RDMDRK--KIEELMEENMTLEMAQKQSMDESLHLGW 428
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNC 336
ELEQ L + E + ++E + + EL ++ +E
Sbjct: 429 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 488
Query: 337 QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS--ETL 394
+I + KE N+ + E +K S ++ +N + + +QL ETL
Sbjct: 489 KILKMEKE--NQRLSKKVEILENEIVQEKQS----LQNCQNLSKDLMKEKAQLEKTIETL 542
Query: 395 NQDTDK--KINKNEIAKLEMVIQSLN-KDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQ 451
+++++ KI + E L + SL + + E + KD K+T
Sbjct: 543 RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARV--KDIEKENKILHESIKETSSKL 600
Query: 452 LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI--KDVNVKDLIEKLKSAE 509
++E ++ L H E E+ L++E N+ + K N+K EK+++ E
Sbjct: 601 SKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALE 659
Query: 510 EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ 569
++ N E++ N+ + K + K Q++ S++ + N E+ R E L S
Sbjct: 660 QE----NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 715
Query: 570 KVA-------ELEEEKGNLQ--LHLVDYDSGRMIESDVYKKMIEMEN-----LAETRLKA 615
K+A ELE EK L+ L L+ + +V + +++EN E K
Sbjct: 716 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 775
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
I LES+ DL E LQ+ +E++ IS + +Q+ E KS LE++ L K
Sbjct: 776 IQQLESELQDLEMENQTLQKNLEELK-----ISSKRLEQLEKENKS--LEQETSQLEKDK 828
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK--LEKMSAEKIS 733
K+L EN +L ++ IKD ++ ++ K+ N +EN L+ + + K S ++
Sbjct: 829 KQLEK--ENKRLRQQ---AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLK 881
Query: 734 ELLAK 738
EL K
Sbjct: 882 ELKKK 886
Score = 48.0 bits (109), Expect = 3e-04
Identities = 128/582 (21%), Positives = 230/582 (39%), Gaps = 61/582 (10%)
Query: 1059 NMEEEMQRVSKQLL-DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
N + E QRV+K++ D+ L ILVR+ +E + + M++P +II
Sbjct: 53 NPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIM--MSLPNV--LIIGKN 108
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ-EQSAKLNTELQEC---YT 1173
P S+ + ++ Q++EEFI+ L + A + +QE
Sbjct: 109 --PFSEQGTE-EVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE 165
Query: 1174 KIIQLETLN-TELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR----------- 1221
+ L+ + T+++ D+ + + + L++L E D T+ EL
Sbjct: 166 NVFDLQWMEVTDMSQEDI--EPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPH 223
Query: 1222 --SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSST 1279
SS S G + E +QHL+ AD + LR +L E K EQLLD Q
Sbjct: 224 ASSSAQSPCGSPGMKRTES-RQHLSVELADAKAKIRRLRQEL---EEKTEQLLDCKQELE 279
Query: 1280 QEETN-KIVTMEQVTSLQNKLQDK--EEHLRNLQEKYADVIN-QIEILRSEIEDEKVAFX 1335
Q E K + E + L + + + L L+EK V + E+ R + + F
Sbjct: 280 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 339
Query: 1336 XXXXXXXXXXXXXXXDLRT--ENQ-SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ +T E+Q + + + + +EN QLK
Sbjct: 340 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 399
Query: 1393 XRVNDA--EAKVLELTHQLELKDS-------EIYQKTHEYTITLTQR--NDEFENVRQQL 1441
++ + E LE+ + + +S E +T E + + ++ E +L
Sbjct: 400 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 459
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
++ E + LT E EL + NA+ M+KE++ K +E L +I +
Sbjct: 460 LKLEMENQSLTKTVE-ELRTTVDSVEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQS 517
Query: 1502 NKQVAELNKALEEEVAKTNE-MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSF 1560
+ L+K L +E A+ + ++T EN E +I L E +L V SS + + +S
Sbjct: 518 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV--SSLRQRSQISA 575
Query: 1561 ASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRDVR 1602
+ K E NK L +++ L+ +R ++
Sbjct: 576 EARVKDIEKE------NKILHESIKETSSKLSKIEFEKRQIK 611
>AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein.
Length = 2069
Score = 95.9 bits (228), Expect = 1e-18
Identities = 162/811 (19%), Positives = 347/811 (42%), Gaps = 63/811 (7%)
Query: 544 IDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
+D+ +K S K+++ ++EL K ++E+E L + + ++ + + +V K
Sbjct: 438 LDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAV-LSQKEVELKAS 496
Query: 604 EME-NLAETRLKA-ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
E + +L E L I+ S K L Q + Q+ D+ L DI + QS ++ EIK
Sbjct: 497 ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE-QSRKL-QEIKE 554
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLT 721
+ Q++ + +L + + + + +++ E+ K + +
Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAK 614
Query: 722 DKLEKMSAEKISELLAKINHEEQSKIQT-QFGIDAKIQERDLYIENIESELSKYKSRICR 780
D+ + E L KIN E+Q KIQ Q ++ ++ E +++ + + K R R
Sbjct: 615 DQGKPEVGEYAK--LEKINAEQQLKIQELQEKLEKAVKASTEATELLQN-IRQAKERAER 671
Query: 781 LEESIAVMEDRRYSLERK---ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
E + ED + +K A++ L+ K K +E+ L + + + +
Sbjct: 672 ELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQM 731
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN---RTDLAESEST 894
++LE+E +++E Q Q +L++ L +QHY ++ + + DLA+ E+
Sbjct: 732 ADKILELEEKHREAQVSAQ-------HLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETL 784
Query: 895 KYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY--E 951
+ Q + E++ K +I E + +I +I LE +E + +K N +
Sbjct: 785 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI---VELSEANKLAANSSLFTQ 841
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
+N++ ++ ++L++ K +E +E N+ +++ ++K Q + +
Sbjct: 842 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRK----LEEQLEKISHQDHSDKNRLLELE 897
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
+L + + +E+ + L +++ Q+S + + ES+L +E ++++ +L
Sbjct: 898 TRLREVSLEHEEQKLELKRQLTELQLS----LQERESQLTALQAARAALESQLRQAKTEL 953
Query: 1072 LDSK-QHNEELQILVREQDD---QIKELKE-----TKLTFEMNIPKTEGMIISST---IE 1119
++ + EE+Q L +D+ + L+ T L ++N + +++ +
Sbjct: 954 EETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLS 1013
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLE 1179
D+A+ + L+ + E +Q S Q A L T +++ LE
Sbjct: 1014 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA-LKTTCTMLEEQVMDLE 1072
Query: 1180 TLNTELTGHD---VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
LN EL + + + KS+ E E +L T + R+ DQR E
Sbjct: 1073 ALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRAR----ADQRITESR 1128
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
++ + + + +A+ + L+ Q ES ++L D + E N SLQ
Sbjct: 1129 QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMN-------ARSLQ 1181
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
KL+ + E + L E+ A + Q+++ ++ I
Sbjct: 1182 QKLETERELKQRLLEEQAKLQQQMDLQKNHI 1212
Score = 91.9 bits (218), Expect = 2e-17
Identities = 139/769 (18%), Positives = 331/769 (43%), Gaps = 49/769 (6%)
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
+VS + + ++L ++ S+K+ E++E++ Q+ + ++ E V + +L
Sbjct: 527 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSAR--RRSDL 584
Query: 609 AETRLKAISLL-ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E+ L+ L E K + H L + D+ + ++ + ++L+ ++K L+E+
Sbjct: 585 YESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 644
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLEN---DKEDIMNKLQNYIQENMDLTDKL 724
++ + E +++N++ KE+ ++ L+N E I KL + L +K+
Sbjct: 645 LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKV 704
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFG-----IDAKIQERDLYIENIESELSKYKSRIC 779
+++ + E K + + +S+ Q ++ K +E + +++E L K +
Sbjct: 705 KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHL---KQKEQ 761
Query: 780 RLEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
EE I V++++ + L K + +++A+ + I ++ + + R +E
Sbjct: 762 HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKA-MINAMDSKIRSLE 820
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQIS-LSDMQQHYNAL------VEKANRTDLAES 891
++++E+ NK L + + + N Q +S+++Q L +E NR +
Sbjct: 821 QRIVELSEANK-LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 879
Query: 892 ESTKYQ-----TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
E +Q +L +LE+ L+ ++ EH+ ++ K+++ +L++ + ES + +
Sbjct: 880 EKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER-ESQLTALQAA 938
Query: 947 NEKYEKNIEYV-TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQSPDY 1003
E + T+LE E + I+ L + +E+ + L + + + Q
Sbjct: 939 RAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 998
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQKI--NNAQVSYMSM-VSDYESKLAQFTTKLENM 1060
TE E+N N L ++ +E N +I ++V ++ +++ E +L +E +
Sbjct: 999 TEDNA-ELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL 1057
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
+ + +Q++D + N+EL R+ + L + K FE + + + M ++
Sbjct: 1058 KTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-----LDT 1112
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK---LNTELQECYTKIIQ 1177
D + + E + + L+EQ K L+ +L + K
Sbjct: 1113 EKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAM 1172
Query: 1178 LETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
LE +N + + ++ Q L + +L + D + + L + A+D+ ++
Sbjct: 1173 LE-MNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA--DLL 1229
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNK 1285
+ + L + + Q +V++ S+ +L+D +Q+ + K
Sbjct: 1230 KTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 1278
Score = 88.6 bits (210), Expect = 2e-16
Identities = 149/775 (19%), Positives = 321/775 (41%), Gaps = 70/775 (9%)
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQ 897
L+ + ++KK I +E Q+ Q M+Q L + + + E E +
Sbjct: 438 LDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE 497
Query: 898 TQLRDLESNLKRITHEHQTL---IVQKKKEI---EDLEIEFNTQIESAIRD-KKVLNEKY 950
TQ LE +L E +L + Q + E+ +D ++ I R +++ ++Y
Sbjct: 498 TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY 557
Query: 951 EKNIEYVTQLEAQLQE-----------YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQ 999
+ +E + + QL+E Y++ + + EE + E K ++ +
Sbjct: 558 QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQG 617
Query: 1000 SPDYTEQY-INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
P+ E + +IN L Q+ +E + K + + + + + + KL+
Sbjct: 618 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ 677
Query: 1059 NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTI 1118
N E+ + + K+L+++++ L+ V+ + E +E +L K + S I
Sbjct: 678 NREDSSEGIRKKLVEAEERRHSLENKVKRLETM--ERRENRL-------KDDIQTKSQQI 728
Query: 1119 EPMSDDANNVDXXXXXXXXXXXXLKV--QEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+ M+D ++ L+V +++E+ +E+ + + K + +E ++
Sbjct: 729 QQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMM 788
Query: 1177 QLETLNTELTGHDVVNQE-QINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE- 1234
Q G + Q+ IN + SK+ L L + A ++ SS QR +
Sbjct: 789 QRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL--SEANKLAANSSLFTQRNMKA 846
Query: 1235 ----IAELWKQHL------AQREADFQKTEHELRVQLSAFESKYEQLLDSV----QSSTQ 1280
I+EL +Q + EA +K E +L S +LL+ + S +
Sbjct: 847 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE 906
Query: 1281 EETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED---EKVAFXXX 1337
E K+ Q+T LQ LQ++E L LQ A + +Q+ ++E+E+ E
Sbjct: 907 HEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA 966
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
LR ++EQ + + E+NA+L + +
Sbjct: 967 LTAHRDEIQRKFDALRNSCTVITDLEEQ-LNQLTEDNAELNNQN----FYLSKQLDEASG 1021
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTI---TLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
A ++++L +++ EI ++ + T T+ + +Q+++ E + D E
Sbjct: 1022 ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLE-ALNDELLE 1080
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
KE + R + + + +E +E + + ++ + + ++ ++QV EL A++E
Sbjct: 1081 KERQWEAWRSVLGDEKSQFECRVRELQ-RMLDTEKQSRARADQRITESRQVVEL--AVKE 1137
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQN---MVRASSSKIQKHVSFASDTKQ 1566
A+ +Q AL+ Q+++ +L+D++ +L+ M+ ++ +Q+ + + KQ
Sbjct: 1138 HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ 1192
Score = 88.2 bits (209), Expect = 2e-16
Identities = 185/890 (20%), Positives = 366/890 (41%), Gaps = 76/890 (8%)
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
+E D DK KM E ++ L +++ E Q + + A +R L +E +L+ Y
Sbjct: 456 KELQDSQDKCHKMEQE-MTRLHRRVSEVEAVLSQKEVELKASETQRSL----LEQDLATY 510
Query: 775 KSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL-VNRLAVLM-- 831
+ L+ S+ + KA QL ++E+ + E QE + V + ++M
Sbjct: 511 ITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQ 570
Query: 832 -DHDRVVEKQLLEI-EHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDL 888
+ D V ++ ++ E E +E + + + Q L + V E A +
Sbjct: 571 LEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKI 630
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTL--IVQKKKEIE-DLEIEFNTQIES-AIRDKK 944
+ K Q LE +K T + L I Q K+ E +LE N + S IR K
Sbjct: 631 NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL 690
Query: 945 VLNEK----YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ---- 996
V E+ E ++ + +E + K++I+ + ++++ LEL +KH + Q
Sbjct: 691 VEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQ 750
Query: 997 --QTQSPDYTEQYINEINKLNALLKQK--DEEIIA-LNQKINNAQVSYMSMVSDYESKLA 1051
+ + Y +I L+ +K+ D+E + + Q+ ++S+ ++ +
Sbjct: 751 HLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMIN 810
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
+K+ ++E+ + +S+ + + Q ++ Q++ I EL++ K E K E
Sbjct: 811 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 870
Query: 1112 MI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-ERSV------LQEQSA 1162
+ +E +S ++ + ++ EE+ ++ +R + LQE+ +
Sbjct: 871 QNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERES 930
Query: 1163 KLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
+L T LQ + QL TEL +E+I L + +++ + D L ++ +
Sbjct: 931 QL-TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI- 988
Query: 1222 SSISSAVDQRGFEIAELWKQHL-AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQ 1280
+ + ++Q + AEL Q+ ++ D ++ VQL S+ + L +
Sbjct: 989 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQL---RSEVDHLRREITEREM 1045
Query: 1281 EETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXX 1340
+ T++ TME + + L+++ L L ++ + Q E RS + DEK F
Sbjct: 1046 QLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRE 1105
Query: 1341 XXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ---LKKSSXXXXXXXXXXXXRVND 1397
+Q + ++ L + E A+ L+++ ++ND
Sbjct: 1106 LQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLND 1165
Query: 1398 AEAK--VLELT-HQLELK---DSEIYQKTHEYTITLTQRNDEFEN----VRQQLVEYEKR 1447
E K +LE+ L+ K + E+ Q+ E L Q+ D +N + Q L E R
Sbjct: 1166 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDR 1225
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNK---- 1503
DL + S+L + +H + + + ++ KLI+ L K+ + K
Sbjct: 1226 A-DLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS 1284
Query: 1504 --------------QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
Q EL ALE+E A+ E++ AL+ IE+ + +E
Sbjct: 1285 RRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREE 1334
Score = 85.0 bits (201), Expect = 2e-15
Identities = 164/934 (17%), Positives = 387/934 (41%), Gaps = 66/934 (7%)
Query: 353 GTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEM 412
G E V K ++ R + + S + + L + + + ++++ K+E
Sbjct: 411 GEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQ 470
Query: 413 VIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNT 472
+ L++ + + E V+S+K+ + +A E + +
Sbjct: 471 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQ 530
Query: 473 ED------VNEI----AKVQEQLKQELNDEIKDVNV------KDLIEKLKSAEEQITQLN 516
ED +++I K+QE +QE +++++ + +DL+ + ++ ++L
Sbjct: 531 EDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR 590
Query: 517 DEIDAANKNMIK-VKSNHK-LKLKQMQK-TIDNFSKVSDSNKE----IVRLTEELH---- 565
+ AA + K + HK LK K K + ++K+ N E I L E+L
Sbjct: 591 ESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVK 650
Query: 566 ---HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEME---NLAETRLKAISLL 619
++ + + + K + L + + KK++E E + E ++K + +
Sbjct: 651 ASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 710
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSD-QVCSEIKSVHLEEQIDALSASKKEL 678
E ++ L ++ Q+ ++ DK+ ++ + + QV ++ VHL+++ K L
Sbjct: 711 ERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVL 770
Query: 679 ALVIENLKLDKEQLYGTIKDLE---NDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KIS 733
I+ DKE L ++ E ++K I+++ + I LE+ E + +
Sbjct: 771 DNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 830
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+L A + Q ++ Q + ++++++ Y +E++ K +++ +LEE + + + +
Sbjct: 831 KLAANSSLFTQRNMKAQEEMISELRQQKFY---LETQAGKLEAQNRKLEEQLEKISHQDH 887
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S + + +L + L+E + E Q+ EL +L L + E QL ++ L+
Sbjct: 888 SDKNRLLELETRLREVSLEHEE---QKLELKRQLTELQLSLQERESQLTALQAARAALES 944
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ L + L+ + ++ ++ AL + T + DLE L ++T +
Sbjct: 945 Q---LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTED 1001
Query: 914 HQTLIVQK---KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ L Q K++++ + ++ + E E+ ++ +Q + ++ K
Sbjct: 1002 NAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQT-MEALKTT 1060
Query: 971 IENLNMNVEELNKMNLELIDKHVQKQQTQS--PDYTEQYINEINKLNALLKQKDEEIIAL 1028
L V +L +N EL++K Q + +S D Q+ + +L +L + +
Sbjct: 1061 CTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARA 1120
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+Q+I ++ V ++++++ L+ + + + +S +L D ++ + L++ R
Sbjct: 1121 DQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSL 1180
Query: 1089 DDQI---KELK------ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXX 1139
++ +ELK + KL +M++ K ++ ++ D A+ +
Sbjct: 1181 QQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQL 1240
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAK---LNTELQECYTKIIQLETLNTELTGHDVVNQEQI 1196
++V E ++ + +Q+ L ++ + K L + E Q
Sbjct: 1241 ENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQY 1300
Query: 1197 NQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
N+LK LE+ L + + R + SA ++
Sbjct: 1301 NELKLALEKEKARCAELEEALQKTRIELRSAREE 1334
Score = 59.7 bits (138), Expect = 9e-08
Identities = 165/872 (18%), Positives = 342/872 (39%), Gaps = 71/872 (8%)
Query: 243 IESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEP 302
+ K+V + + E LLE E S L + LEQ L I
Sbjct: 486 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLL-HDIRE 544
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSP 362
+ EI+E+ A + E+ + LE R+ + E++L ES+ +
Sbjct: 545 QSRKLQEIKEQEYQ--AQVEEMRLMMNQLEEDLVSARRRSDLYESEL----RESRLAAEE 598
Query: 363 SKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLV 422
K+ + K + E +N + KI + + KLE +++ +
Sbjct: 599 FKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQ-EKLEKAVKASTEATE 657
Query: 423 DKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ 482
+ + K+ +D+ + ++ +E H + E+ + +
Sbjct: 658 LLQNIRQAKERAERELEKLQNREDS----SEGIRKKLVEAEERRH---SLENKVKRLETM 710
Query: 483 EQLKQELNDEI--KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
E+ + L D+I K ++ + +K+ EE+ + ++ + + +++ K+K +
Sbjct: 711 ERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVL 770
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYK 600
I ++ + +++ EE H K+ ++ N + R++E
Sbjct: 771 DNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 830
Query: 601 KMIEMENL-AETRLKA----ISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQ 654
K+ +L + +KA IS L QKF L + L+ + ++E++L IS Q SD
Sbjct: 831 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD- 889
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
+ + + LE ++ +S +E L LK +L ++++ E+ +
Sbjct: 890 ---KNRLLELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALE 943
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
+ +LE+ +AE E+ A H ++ IQ +F DA ++ I ++E +L+
Sbjct: 944 SQLRQAKTELEETTAEAEEEIQALTAHRDE--IQRKF--DA-LRNSCTVITDLEEQLN-- 996
Query: 775 KSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHD 834
+L E A + ++ + L ++ D+ E + SE E+ R L
Sbjct: 997 -----QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 1051
Query: 835 RVVE---KQLLEIEHENKELQKKNQILLEENQNLQI---SLSDMQQHYNALVEKANRTDL 888
+ +E +E + +L+ N LLE+ + + L D + + V + R
Sbjct: 1052 QTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD 1111
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
E +S Q RIT Q + + K+ ++ ++ A++++K+
Sbjct: 1112 TEKQSRARADQ---------RITESRQVVELAVKEHKAEI-----LALQQALKEQKL--- 1154
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
K E + + LE + + N +L +E ++ L+++ + QQ D + +I
Sbjct: 1155 KAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM--DLQKNHI 1212
Query: 1009 NEINK-LNALLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+ + L L + D E L ++ N QV Y E ++Q T ++ ++ +M
Sbjct: 1213 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKM 1272
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
+ +K+ +E L + Q ELK
Sbjct: 1273 DQPAKKKKGLFSRRKEDPALPTQVPLQYNELK 1304
Score = 40.3 bits (90), Expect = 0.056
Identities = 95/487 (19%), Positives = 190/487 (39%), Gaps = 46/487 (9%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDL-QEKINEKDQI--IEAKNKATTXXXXXX 200
+ LS K N+ Q MK E I +L Q+K + Q +EA+N+
Sbjct: 823 IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 882
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
K ++ +++ + E +++K L + + + + E L
Sbjct: 883 SHQD-------HSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTAL 935
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
+AAR + + + ELE+ A++ I+ + EI+ K +
Sbjct: 936 QAARAALESQLRQAKTELEETTAE-----------AEEEIQALTAHRDEIQRKFDALRNS 984
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS-RKSGRNTA 379
T +T +L E LN Q+ + N EL N+ + SK + S ++ R +
Sbjct: 985 CTVIT---DLEEQLN-QLTEDNAELNNQNFYL---SKQLDEASGANDEIVQLRSEVDHLR 1037
Query: 380 SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXX 438
++ QL+S+ + K + + M +++LN +L++KE +
Sbjct: 1038 REITEREMQLTSQKQTMEA-LKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEK 1096
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLK-QELNDEIKDVN 497
L L E Q I T + V E+A + + + L +K+
Sbjct: 1097 SQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILALQQALKEQK 1153
Query: 498 VK--DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+K L +KL E++ L E++A + K+++ +LK + +++ ++
Sbjct: 1154 LKAESLSDKLNDLEKKHAML--EMNARSLQQ-KLETERELKQRLLEEQAKLQQQMDLQKN 1210
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
I RLT+ L + L+ E+ +L+ L + I+ + ++ME + K
Sbjct: 1211 HIFRLTQGLQEALDRADLLKTERSDLEYQLEN------IQVLYSHEKVKMEGTISQQTKL 1264
Query: 616 ISLLESQ 622
I L+++
Sbjct: 1265 IDFLQAK 1271
>AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein
protein.
Length = 2121
Score = 95.9 bits (228), Expect = 1e-18
Identities = 248/1399 (17%), Positives = 551/1399 (39%), Gaps = 100/1399 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ + + ++ E EW +++ +L K++ + LEE N++L+ ++ EH
Sbjct: 341 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE-EH 399
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELL 331
Q+ KQ T+++ + +E+ ++ +LL
Sbjct: 400 LSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR--VEMLETERGQQEAKLL 457
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ ++L + + + + +S +K+ S+ G +++ S S+L+
Sbjct: 458 AERG-HFEEEKQQLSSLITDLQSSISNLSQ-AKEELEQASQAHGARLTAQVASLTSELT- 514
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQ 451
TLN ++ E+A L+ + L + +++ + L +
Sbjct: 515 -TLNATIQQQ--DQELAGLKQQAKEKQAQLAQ---TLQQQEQASQGLRHQV---EQLSSS 565
Query: 452 LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA--- 508
L+ + QQ E T + ++A E+ + L + + + +EK K+A
Sbjct: 566 LKQKEQQLKEVAEK-QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 624
Query: 509 --EEQITQLNDEIDAANKNMIKV---KSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLTE 562
++Q+ N+ D+A ++ + K+ K++++Q ++ + ++ ++ L
Sbjct: 625 ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 684
Query: 563 ELHHLSQKVAELE---EEKGNLQLHLVDY-DSGRMIESDVYKKMIEMENLAETRLKAISL 618
+L QK E E +EK LQ L +S ++ + + ++ + E + + IS
Sbjct: 685 QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE 744
Query: 619 LESQKFDLVQELHILQQKYDEVE-----DKLADISQL-QSDQVCSEIKSVHLEEQIDALS 672
L+++ LV++ H ++K E E A + QL ++ Q +E+ L E + A
Sbjct: 745 LKAETRSLVEQ-HKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 803
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLEN----DKEDIMNKLQNYIQENMDLTDKLEKMS 728
++ E +++ + +E+ + ++ +E +M + + +L + EK++
Sbjct: 804 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 863
Query: 729 A-EKISELLAKINHEEQSKIQTQFG-IDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
E SEL E +++ ++QE+++ + + +LS + ++ + +A
Sbjct: 864 GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVA 923
Query: 787 VMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
+E R + E++ ++E +A +E R ++ E E
Sbjct: 924 RLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR--QFCSTQAALQAMEREAE 981
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR--TDLAESESTKYQTQLRDL 903
EL++ L+E Q ++ L ++ R DLA ++ + + ++R L
Sbjct: 982 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR-L 1040
Query: 904 ESNLKRITHEHQTL-----IVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEKNIEYV 957
++ L E TL +KE +D E+ +E+A I++ + L + ++ E +
Sbjct: 1041 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1100
Query: 958 TQLEAQ-------LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
+ E + E E +E L + + +++ QKQQ Q+ D E+ + E
Sbjct: 1101 AKKEKEHASGSGAQSEAAGRTEPTGPKLEAL-RAEVSKLEQQCQKQQEQA-DSLERSL-E 1157
Query: 1011 INKLNALLKQKDEEII--ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
+ + + E + L +K S S ++ + +LA F TK+++ +
Sbjct: 1158 AERASRAERDSALETLQGQLEEKAQELGHS-QSALASAQRELAAFRTKVQDHSKAEDEWK 1216
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII--SSTIEPMSDDAN 1126
Q+ +Q E L+ ++++ L L E + + +++ S + + +
Sbjct: 1217 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1276
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
+ EE R ++Q QE ++ + E L EL
Sbjct: 1277 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1336
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
QE+ Q + L L E+ + + V+EL + Q E A K+H +
Sbjct: 1337 AW----QEKFFQKEQALSTLQLEHTSTQALVSELLPA-KHLCQQLQAEQAAAEKRHREEL 1391
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE-------TNKIVTMEQVTSLQNKL 1299
E ++ LR +L + + +L+ Q ++E K EQ++ L+
Sbjct: 1392 EQS-KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1450
Query: 1300 QDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
E R L E+ A++ Q L E++ + + +++ E QS
Sbjct: 1451 GLLAEENRGLGER-ANLGRQ--FLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS- 1506
Query: 1360 KQMQEQSILNINEENAQLK--KSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE-----LK 1412
+E ++ E A++K + +V E E T Q+E L
Sbjct: 1507 -TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1565
Query: 1413 DSEIYQKTHEYTITLTQ-RNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
DS+ K + + Q + E + Q+L ++ +KE +L+M +
Sbjct: 1566 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1625
Query: 1472 HYETMQKESE--IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
HY+ +++++ E+++ +E+L E+ L + L L++ KT E + +
Sbjct: 1626 HYDAKKQQNQELQEQLRSLEQLQ---KENKELRAEAERLGHELQQAGLKTKEAEQTCRHL 1682
Query: 1530 EIEIVTLNDEITNLQNMVR 1548
++ +L ++ + +R
Sbjct: 1683 TAQVRSLEAQVAHADQQLR 1701
Score = 93.5 bits (222), Expect = 6e-18
Identities = 267/1445 (18%), Positives = 571/1445 (39%), Gaps = 117/1445 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDI-----ESKDVRISSLEEANKL--LEAARF 265
D + +T + + K EK ++ + I E+ D+ E A+ L L+ A
Sbjct: 289 DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALN 348
Query: 266 EISLEHSKLAQE-LEQXXXXXXXXXXXXXX---------LAKQSIEPSCEEKTEIEEKGS 315
E++ EHSK QE LE+ + + + E +++++
Sbjct: 349 ELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 408
Query: 316 LEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTE--SKAVSSPSKKGSPLISRK 373
E + ++E L+ + N +L+ ++ + TE + +++G ++
Sbjct: 409 QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 468
Query: 374 SGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDT 433
+ + ++S S LS ++ ++ ++ A+L + SL +L I ++D
Sbjct: 469 QLSSLITDLQSSISNLSQA---KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQ 525
Query: 434 XXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEI 493
K +AQ + +Q +G L H E ++ K +EQ +E+ ++
Sbjct: 526 ELAGLKQQAKEKQAQLAQTLQQQEQASQG--LRH---QVEQLSSSLKQKEQQLKEVAEK- 579
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
++ +D ++L +A E+ E DAA K + ++ KL+ +Q+ + ++ DS
Sbjct: 580 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 639
Query: 554 NK-EIVRLTEELHHLSQKVAELEE--EKGNLQLHLVDYDSGRM---IESDVYKKMIEMEN 607
+ + + E LS+KV EL+ E + H + + S+ +K E E
Sbjct: 640 AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE-QQKATEKER 698
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVC-SEIKSVHLEE 666
+A+ + L+ Q L + L + + +E + + AD L+ Q C SE+K+
Sbjct: 699 VAQEK----DQLQEQLQALKESLKVTKGSLEEEKRRAADA--LEEQQRCISELKA-ETRS 751
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
++ +KEL E + ++ L ++ L + L+ + E M E
Sbjct: 752 LVEQHKRERKEL----EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 807
Query: 727 MSAEKISELLA-KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
+ + E+ A + +E+ + + Q+G A QE+ + ++ E K + + +E +
Sbjct: 808 ECEQLVKEVAAWRERYEDSQQEEAQYG--AMFQEQ---LMTLKEECEKARQELQEAKEKV 862
Query: 786 AVMEDR-RYSLERKADQLGSY---LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQL 841
A +E + R+ ++L L + E ++ +L + L+ L + K++
Sbjct: 863 AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 922
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR----TDLA----ESES 893
+E ++ ++ + E D Q + L E+ R T A E E+
Sbjct: 923 ARLETLVRKAGEQQETASRELVKEPARAGDRQPEW--LEEQQGRQFCSTQAALQAMEREA 980
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
+ +L L + L + Q Q+++E+ L E + ++ + +K + E
Sbjct: 981 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE-RGRAQADLALEKAARAELEMR 1039
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
++ L Q E+ E L + E + EL ++ + E+ + +
Sbjct: 1040 LQ--NALNEQRVEFATLQEALAHALTEKEGKDQELAK--LRGLEAAQIKELEELRQTVKQ 1095
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
L L +K++E + + AQ KL ++ +E++ Q+ +Q D
Sbjct: 1096 LKEQLAKKEKE----HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQA-D 1150
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
S + + E + R + D E + +L + + ++ + S+ E + D
Sbjct: 1151 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1210
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
+ ++E E ++ S++ + L E+ ++++ E + EL +
Sbjct: 1211 AEDEWKAQVARGRQEAE--RKNSLI----SSLEEEVSILNRQVLEKEGESKELKRLVMAE 1264
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD--QRGFEIAELWKQHLAQREADF 1250
E+ +L+ +L L E + + AE S++ V + E + ++L Q
Sbjct: 1265 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ 1324
Query: 1251 QKTEHELRVQLSAFESKY---EQLLDSVQ---SSTQEETNKIVTMEQVTS-LQNKLQDKE 1303
+ EL +L A++ K+ EQ L ++Q +STQ ++++ + + LQ + E
Sbjct: 1325 AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE 1384
Query: 1304 E-HLRNL-QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
+ H L Q K A + E+LR++ E + LR E SY +
Sbjct: 1385 KRHREELEQSKQAAGGLRAELLRAQRE---LGELIPLRQKVAEQERTAQQLRAEKASYAE 1441
Query: 1362 ---MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH-QLELKDSEIY 1417
M +++ + EEN L + + + + + L E + +E+
Sbjct: 1442 QLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1501
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
++ L ++E + +++E +R +++E R K+ E Q
Sbjct: 1502 REAQSTARELEVMTAKYEGAKVKVLEERQR-----FQEE------RQKLTAQVEQLEVFQ 1550
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLN 1537
+E + K +EEL+ K+ +S +K + KA++ + ++ + L+ Q E+
Sbjct: 1551 RE----QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1606
Query: 1538 DEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+ + K + H Q EQL + + + RAE + + L
Sbjct: 1607 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ 1666
Query: 1598 QRDVR 1602
Q ++
Sbjct: 1667 QAGLK 1671
Score = 87.0 bits (206), Expect = 5e-16
Identities = 178/901 (19%), Positives = 352/901 (39%), Gaps = 85/901 (9%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEK---ISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
M +L+ + + D+LE AE ++E A+I +Q +I ++ K L
Sbjct: 222 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQ-RIDRLALLNEKQAASPLE 280
Query: 764 IENIESELSKYKSRICRLEESIAVMED---RRYSLERKADQLGSY---LQEKQKAYSEYT 817
+ +E K +S RL E++ +D + ++RK +QL L K + ++ +
Sbjct: 281 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 340
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQ 874
Q + +N L +H + ++ L + KEL + + L E+N+ LQ LS +++
Sbjct: 341 QQLQDALNELTE--EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 398
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
H + L + + + E QL L+ + + Q + +E LE E
Sbjct: 399 HLSQLQDNPPQE---KGEVLGDVLQLETLKQEAATLAANN----TQLQARVEMLETERGQ 451
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q + ++ E+ + QL + + + +++I NL+ EEL + + H
Sbjct: 452 QEAKLLAERGHFEEEKQ-------QLSSLITDLQSSISNLSQAKEELEQAS----QAHGA 500
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES------ 1048
+ Q T +E+ LNA ++Q+D+E+ L Q+ Q + E
Sbjct: 501 RLTAQVASLT----SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR 556
Query: 1049 -KLAQFTTKLENMEEEMQRVS-KQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
++ Q ++ L+ E++++ V+ KQ + H ++L E++ ++E LK+ +
Sbjct: 557 HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALE 616
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI----QERSVLQ 1158
+ K E + + + D+ KV+E + + QE+ Q
Sbjct: 617 KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 676
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
Q A+L +L+ K + E + E D + QEQ+ LK L+ + A
Sbjct: 677 AQVAELELQLRSEQQKATEKERVAQE---KDQL-QEQLQALKESLKVTKGSLEEEKRRAA 732
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
+ + + E L +QH +R K E R E++ +QL ++ Q+
Sbjct: 733 DALEEQQRCISELKAETRSLVEQHKRER-----KELEEERAGRKGLEARLQQLGEAHQAE 787
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
T+ V ++ E L ++ A + E + E F
Sbjct: 788 TE------VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQL 841
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+L+ + ++ S L I+ + +L + +V +
Sbjct: 842 MTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAE----LHANLARALQQVQEK 897
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYT--ITLTQR-NDEFENVRQQLVEYEKRIEDLTYEK 1455
E + +L L ++ + E TL ++ ++ E ++LV+ R D E
Sbjct: 898 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 957
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
E + + A + M++E+E + +E L + ES Q E E E
Sbjct: 958 LEEQQGRQFCSTQAA--LQAMEREAE-QMGNELERLRAALMES---QGQQQEERGQQERE 1011
Query: 1516 VAKTNE----MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQ 1571
VA+ + Q L ++ L + N N R + +Q+ ++ A K+G+D++
Sbjct: 1012 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1071
Query: 1572 L 1572
L
Sbjct: 1072 L 1072
Score = 79.0 bits (186), Expect = 1e-13
Identities = 190/1010 (18%), Positives = 413/1010 (40%), Gaps = 86/1010 (8%)
Query: 638 DEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA-SKKELALVIENLKL----DKEQ- 691
DE+E +LA+ +L +++ + + ++++ID L+ ++K+ A +E +L DK +
Sbjct: 237 DELELELAENRKLLTEK---DAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNES 293
Query: 692 ----LYGTIK---DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH--E 742
L+ T+K DL+ +K + K+ +EN DL+ KL + A + +L +N E
Sbjct: 294 LTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREF-ASHLQQLQDALNELTE 352
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELS-KYKSRICRLEESIAVMEDRRYSLERKADQ 801
E SK TQ ++ + Q +E ELS + + C LEE +++ + LE Q
Sbjct: 353 EHSK-ATQEWLEKQAQ--------LEKELSAALQDKKC-LEEKNEILQGKLSQLEEHLSQ 402
Query: 802 L-GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK--QLLEIEHENKE--LQKKNQ 856
L + QEK + + +Q + L A L ++ ++ ++LE E +E L +
Sbjct: 403 LQDNPPQEKGEVLGD-VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 461
Query: 857 ILLEENQNLQISLSDMQQHYNALVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
EE Q L ++D+Q + L + K +++ + Q+ L S L +
Sbjct: 462 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL----N 517
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
I Q+ +E+ L+ + A + L + ++ + L Q+++ ++++
Sbjct: 518 ATIQQQDQELAGLK-------QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 570
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE----INKLNALLKQKDEEIIALNQK 1031
++E+ + H Q+ T + + E + E + +L AL K+K ++ L Q+
Sbjct: 571 QQLKEVAEKQEATRQDHAQQLATAAEE-REASLRERDAALKQLEALEKEKAAKLEILQQQ 629
Query: 1032 I---NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ N A+ S + V+ + + A+ + K+E ++ ++ ++ +++ EL++ +R +
Sbjct: 630 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 689
Query: 1089 DDQIKELKETKLTFEMNIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ E + + + + + + T + ++ LK +
Sbjct: 690 QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 749
Query: 1147 E---EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
E+ +ER L+E+ A L+ ++ + TE V + ++ + +
Sbjct: 750 RSLVEQHKRERKELEEERAG-RKGLEARLQQLGEAHQAETE------VLRRELAEAMAAQ 802
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL---RVQ 1260
+E + L+ VA R + Q + ++++ L + + +K EL + +
Sbjct: 803 HTAESECEQLVKEVAAWRERYEDS-QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK 861
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
++ ES E + Q+ E N ++QV + + Q + L LQEK A
Sbjct: 862 VAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 921
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA- 1375
+ ++E L + +++ + E Q + Q+ L E A
Sbjct: 922 VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 981
Query: 1376 ----QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI-YQKTHEYTITLTQR 1430
+L++ E +V LT + +++ +K + + +
Sbjct: 982 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1041
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
N E + E LT ++ + + +L+ E A E + ++++K E+
Sbjct: 1042 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLK--EQ 1099
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L K E S + +E E K ++ + E + ++ +L+ + A
Sbjct: 1100 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1159
Query: 1551 SSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
+ + S A +T QG+ E+ + A+ A+ +LA + +D
Sbjct: 1160 RASRAERDS-ALETLQGQLEEKAQELGHS-QSALASAQRELAAFRTKVQD 1207
Score = 62.5 bits (145), Expect = 1e-08
Identities = 103/535 (19%), Positives = 226/535 (42%), Gaps = 44/535 (8%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQI-------LVREQDDQIKELKE--TKLTFEMNIP 1107
L+ + +M+R+ KQL D + + +EL++ L+ E+D QI +++ +L +N
Sbjct: 215 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL-LNEK 273
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
+ + +E + D ++ LK E+ + ++ + L E++ L+ +
Sbjct: 274 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFK 332
Query: 1168 LQECYTKIIQLETLNTELT-GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISS 1226
L+E + + QL+ ELT H QE + K QL E LS + + +
Sbjct: 333 LREFASHLQQLQDALNELTEEHSKATQEWL----EKQAQLEKE----LSAALQDKKCLEE 384
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN-K 1285
+ ++++L ++HL+Q + + + + E+ + E+ ++ ++TQ + +
Sbjct: 385 KNEILQGKLSQL-EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 443
Query: 1286 IVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
++ E+ L ++ EE + L D+ + I L E+ + A
Sbjct: 444 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 503
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNI----NEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+L T N + +Q Q+Q + + E+ AQL ++ +V
Sbjct: 504 AQVASLTSELTTLNATIQQ-QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQL 562
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ + + QL+ + ++ L +E E ++ K++E L EK ++
Sbjct: 563 SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAK 622
Query: 1459 LAILRLKM---HENANHYETMQKESEIERVKL---IEELNVKI----TESVSLNKQVAEL 1508
L IL+ ++ +E + +T +++ E+ +L +EEL + E QVAEL
Sbjct: 623 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL 682
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
L E K E + + ++ L +++ L+ ++ + +++ A+D
Sbjct: 683 ELQLRSEQQKATEKERVAQEKD----QLQEQLQALKESLKVTKGSLEEEKRRAAD 733
>AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 95.5 bits (227), Expect = 1e-18
Identities = 213/1093 (19%), Positives = 454/1093 (41%), Gaps = 84/1093 (7%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
K + + + N K +NVK +++ E + + D ++ KL +
Sbjct: 497 KSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDED 556
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY 599
+ KT++ +K S++E +L + + L +K+ ++EK L+ + + + + Y
Sbjct: 557 LDKTLEE-NKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQ---Y 612
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI--SQLQSDQV-- 655
E + ET L+ +LE + L K D E+ DI +++++++
Sbjct: 613 WAQREAD-FKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATA 671
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
C E+K ++ + L+ +K EL E LK + + I++LE + I+ + Q I+
Sbjct: 672 CLELKFNQIKAE---LAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQR-IK 727
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQS-KIQTQFGIDAKIQERDLYIENIESELSKY 774
E +++ D+ E + I+E +H E + K + + I L
Sbjct: 728 ELINIIDQKE----DTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDS 783
Query: 775 KSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
KS+IC + + E ++ K + S + E QK E E+ + + VL +
Sbjct: 784 KSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIED-IRVLQE 842
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
++ + LL IE+E K + EE L + QQ + L EK N T E +
Sbjct: 843 NNEGLRAFLLTIENELKNEK-------EEKAELNKQIVHFQQELS-LSEKKNLTLSKEVQ 894
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IESAIRDKKVLNEKYE 951
+ + E ++++ ++ Q + K EIE T+ I + + K+++ K +
Sbjct: 895 QIQSNYDIAIAELHVQKSKNQEQEEKIMKLSN----EIETATRSITNNVSQIKLMHTKID 950
Query: 952 --KNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKM-NLELIDKHVQKQQTQSPDYT 1004
+ ++ V+Q+ L++ N E N+ +L+ + N L+ K V++ + Q P+
Sbjct: 951 ELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRE 1010
Query: 1005 EQYINEINKL----NALLK---QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK- 1056
+ + I + ++K +K +I L Q+I Q D ++L + K
Sbjct: 1011 NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY-KDENNRLKEKEHKN 1069
Query: 1057 LENMEEEMQRVSKQLLDSKQH-NEELQILVR---EQDDQIKELKETKLTFEMNIPKTEGM 1112
+++ +E + + +QL + Q N L + ++ E + EL + ++ I + E +
Sbjct: 1070 QDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETI 1129
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER----SVLQEQSAKLNTEL 1168
+ + +E D ++E +E +Q+ L + KL E+
Sbjct: 1130 LETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEI 1189
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + ++ L + N+++ +LK +L + NL A+L+
Sbjct: 1190 TQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK---ADLQRKEEDYA 1246
Query: 1229 DQRGFEIAELWKQ-HLAQREADFQKTEHEL-RVQLSAFESKYEQL---LDSVQSSTQ--- 1280
D + ++ + KQ Q+E + E +L R++++ E K Q LD Q + Q
Sbjct: 1247 DLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLK 1305
Query: 1281 EETNKIVTMEQVTSLQNKLQD---KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXX 1337
E+ N E + + +D KE+ + +++ + Q ++ + ++ + K+
Sbjct: 1306 EQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ-EQTQVEQDQVLEAKLEEVER 1364
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
DL T+N + ++ ++ + L+ R
Sbjct: 1365 LATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNADRKKW 1422
Query: 1398 AEAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
E K++ +T E +++ E+ + + Q+N E E + QL E + ++ E
Sbjct: 1423 LEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN-EMEILTAQLTEKDSDLQKWREE 1481
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
++ +A L +++ A +QK++EIE++K I KI E+ ++ + ++ A +
Sbjct: 1482 RDQLVAALEIQL--KALISSNVQKDNEIEQLKRIISETSKI-ETQIMDIKPKRISSA-DP 1537
Query: 1515 EVAKTNEMQTALE 1527
+ +T + T+ E
Sbjct: 1538 DKLQTEPLSTSFE 1550
Score = 83.0 bits (196), Expect = 8e-15
Identities = 184/963 (19%), Positives = 385/963 (39%), Gaps = 100/963 (10%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK-----EDIMNKLQNYIQENM 718
+EE +A E L+ E+L E+ I E K ED+ KL N +E +
Sbjct: 536 VEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL 595
Query: 719 DLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
L K+ + ++ ++ A+ E K + +QER++ EN E L+ +K +
Sbjct: 596 TLEFKIREEVTQEFTQYWAQ--READFK-------ETLLQEREILEENAERRLAIFKDLV 646
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEK-QKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+ + +D + + + ++ + L+ K + +E + EL+ L +
Sbjct: 647 GKCDTREEAAKDI-CATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENES 705
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT----DLAESES 893
+ + E+E NK++ +NQ ++E N+ D + L T D A++ S
Sbjct: 706 DSLIQELETSNKKIITQNQ-RIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSS 764
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT--------QIESAIRDKKV 945
+L + + + + ++ I ++K + + E++ + + SAI + +
Sbjct: 765 LIINNKL--ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQK 822
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+E+ NI + + LQE + + +E N++ E +K +Q + +
Sbjct: 823 KSEEVRPNIAEIEDIRV-LQENNEGLRAFLLTIE--NELKNEKEEKAELNKQIV---HFQ 876
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYM-SMVSDYESKLAQFTTKLENMEEEM 1064
Q ++ K N L ++ ++I + N I A++ S + E K+ + + ++E +
Sbjct: 877 QELSLSEKKNLTLSKEVQQIQS-NYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 1065 QRVSKQLLDSKQHNEELQILVR-EQDDQIKELKETKLTF---EMNIPKTE-GMIISSTIE 1119
Q+ +EL+ L Q I L L+ E N+P T+ ++ + +
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLV 995
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEE-EEFIQERSVLQEQSAKLNTELQECYTKIIQL 1178
+ + EE +E ++ S Q +L ++++ ++
Sbjct: 996 SKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 1179 ETLNTELTGHDVVNQEQ--------INQLKSKLEQLNTENDNLLSTVAELRSSISSAVD- 1229
+ N L + NQ+ I QLK +L++ N D + V E + ++S
Sbjct: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQG 1115
Query: 1230 -----------QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
+ E ++ H A+ E D + E + + E L DSV+++
Sbjct: 1116 VTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
++ E++T L N LQD +HL L+E+ + Q E EK+
Sbjct: 1176 KDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ--------ETEKL--KEEL 1224
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DL+ + + Y ++E+ + + ++ Q++K ++N+
Sbjct: 1225 SASSARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQKEVSVMRDEDKLLRIKINEL 1283
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
E K + + +L++K I Q Q N+ + V + + +YE+ +DL KE
Sbjct: 1284 EKKKNQCSQELDMKQRTIQQLKE-------QLNN--QKVEEAIQQYERACKDLNV-KEKI 1333
Query: 1459 LAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAK 1518
+ +R+ + E +T ++ ++ KL EE+ TE ++ +L + K
Sbjct: 1334 IEDMRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATELEKWKEKCNDLETKNNQRSNK 1389
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK-IQKHVSFASDTKQGRDEQLDNTMN 1577
+E T + ++ L DE+ + A K +++ + + K+ +N N
Sbjct: 1390 EHENNTDVLG---KLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEA-----ENIRN 1441
Query: 1578 KEL 1580
KE+
Sbjct: 1442 KEM 1444
Score = 77.8 bits (183), Expect = 3e-13
Identities = 176/940 (18%), Positives = 381/940 (40%), Gaps = 81/940 (8%)
Query: 380 SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+++K+ ++ E + + K +NE L +++ NK ++ + I E
Sbjct: 678 NQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKE 737
Query: 440 XXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
L + ++ + + + + + N NE +V + K ++ E K VN
Sbjct: 738 DTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNEN 797
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
+L + A++ ++ I K +V+ N + +++ +V N E +R
Sbjct: 798 ELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPN----IAEIEDI-----RVLQENNEGLR 848
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L + ++ +EEK L +V + + E +NL T K + +
Sbjct: 849 AF--LLTIENELKNEKEEKAELNKQIVHFQQELSLS--------EKKNL--TLSKEVQQI 896
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADIS---QLQSDQVCSEIKSVHL-EEQIDALSASK 675
+S + ELH+ + K E E+K+ +S + + + + + + L +ID L
Sbjct: 897 QSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLD 956
Query: 676 KELALVIENLKLDKEQLYGTIKD-LENDKEDIMNKLQNYIQENMDLTDKLEKMSAE-KIS 733
+ +L ++ G+ +D L N + D++ +Y+ ++++ + E
Sbjct: 957 SVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLG--NDYLVSKQVKEYRIQEPNRENSFH 1014
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRR 792
+ I E + ++ +I+E + IE +++E+ YK RL E+ +D
Sbjct: 1015 SSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLL 1074
Query: 793 YSLERKADQLGSYLQEKQKAYS---EYTIQEDELVNRL--------AVLMDHDRVVEKQL 841
E QL LQEK ++ ++ ++ L A + + + ++E Q
Sbjct: 1075 KEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQK 1134
Query: 842 LEIEHENK---ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+E H K ++ +K I+L+ +NL+ + Q+H V+ ++ E + + T
Sbjct: 1135 VECSHSAKLEQDILEKESIILKLERNLK----EFQEHLQDSVKNTKDLNVKELKLKEEIT 1190
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QL + ++K + + ++E E L+ E + S+ R + + + K +Y
Sbjct: 1191 QLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSA---SSARTQNLKADLQRKEEDY-A 1246
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L+ +L + K I+ + +E++ M E DK ++ + + Q E++ +
Sbjct: 1247 DLKEKLTDAKKQIKQVQ---KEVSVMRDE--DKLLRIKINELEKKKNQCSQELDMKQRTI 1301
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSD--YESKLAQFTTKLENMEEEMQRVSKQLLDSK- 1075
+Q E++ NQK+ A Y D + K+ + +E+ Q Q+L++K
Sbjct: 1302 QQLKEQL--NNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKL 1359
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+ E L + + ++ +L ETK N + + + D+ +
Sbjct: 1360 EEVERLATELEKWKEKCNDL-ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNAD 1418
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ-- 1193
K+ + + ++ ++ K + + + + ++E L +LT D Q
Sbjct: 1419 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1478
Query: 1194 -EQINQLKSKLE-QL------NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
E+ +QL + LE QL N + DN + + + S S Q I ++ + ++
Sbjct: 1479 REERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQ----IMDIKPKRISS 1534
Query: 1246 READFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEE 1282
+ D +TE L +K E +LDS + ST+ +
Sbjct: 1535 ADPDKLQTE-PLSTSFEISRNKIEDGSVVLDSCEVSTEND 1573
Score = 65.7 bits (153), Expect = 1e-09
Identities = 199/1000 (19%), Positives = 422/1000 (42%), Gaps = 106/1000 (10%)
Query: 636 KYDEVEDKLADISQLQSDQ--VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K+ + K+ L S Q + +KS + +D+ S SK I N+K
Sbjct: 471 KFSAIAQKVCVPDTLNSSQEKLFGPVKSSQ-DVSLDSNSNSK------ILNVKRATISWE 523
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKINHEEQSKIQTQFG 752
+++DL D ED++ +L+N +E ++ KL +K + E A I+HEE+ K+
Sbjct: 524 NSLEDLMED-EDLVEELEN-AEETQNVETKLLDEDLDKTLEENKAFISHEEKRKL----- 576
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESI---AVMEDRRYSLERKADQLGSYLQEK 809
DL IE+++ +L K LE I E +Y +R+AD + LQE+
Sbjct: 577 -------LDL-IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQER 628
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ I E+ RLA+ D L + + +E K+ + + +
Sbjct: 629 E-------ILEENAERRLAIFKD---------LVGKCDTREEAAKD--ICATKVETEEAT 670
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN--LKRITHEHQTLIVQKKKEIED 927
+ ++ +N + + +T E TK + + R+ ES+ ++ + ++ +I Q ++ I++
Sbjct: 671 ACLELKFNQIKAELAKTK-GELIKTKEELKKRENESDSLIQELETSNKKIITQNQR-IKE 728
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN-IENLNMNVEELNKMNL 986
L I Q E I + + L E + + + N I N + V + +K +
Sbjct: 729 L-INIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI 787
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALL--KQKDEEIIALNQKINNAQVSYMSMVS 1044
K V + + Q D I+ +A+ ++K EE+ +I + +V
Sbjct: 788 CSERKRVNENELQQ-DEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRV-LQENNE 845
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH---NEELQILVREQDDQIKELKETKLT 1101
+ L +L+N +EE ++KQ++ +Q +E+ + + ++ QI+ + +
Sbjct: 846 GLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIA 905
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS 1161
E+++ K++ I +S N ++ +K+ + I E L S
Sbjct: 906 -ELHVQKSKNQEQEEKIMKLS---NEIETATRSITNNVSQIKLMHTK--IDELRTLDSVS 959
Query: 1162 AKLNTELQECY-----TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND--NLL 1214
N +L ++ L +L G+D + +Q+ + ++++ N EN + +
Sbjct: 960 QISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEY--RIQEPNRENSFHSSI 1017
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLD 1273
+ E I A ++ +I EL +Q Q E K E+ R++ +++ + L +
Sbjct: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENN-RLKEKEHKNQDDLLKE 1076
Query: 1274 S---VQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q +E K VT++ +Q+ ++ K L L + +I+ L + +E +
Sbjct: 1077 KETLIQQLKEELQEKNVTLD--VQIQHVVEGKRA-LSELTQGVTCYKAKIKELETILETQ 1133
Query: 1331 KVAFXXXXXXXXXXXXXXXXDLRTEN--QSYKQMQEQSILN---INEENAQLKK--SSXX 1383
KV L+ E + +++ + S+ N +N + +LK+ +
Sbjct: 1134 KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT 1193
Query: 1384 XXXXXXXXXXRVNDAEAKV-LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
++ + E + + T +L+ + S +T L ++ +++ +++++L
Sbjct: 1194 NNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLT 1253
Query: 1443 EYEKRIEDLTYE---KESELAILRLKMHE-----NANHYETMQKESEIERVKLIEEL-NV 1493
+ +K+I+ + E E +LR+K++E N E K+ I+++K E+L N
Sbjct: 1254 DAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLK--EQLNNQ 1311
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
K+ E++ +Q K L + +M+ LE QE V + + V +++
Sbjct: 1312 KVEEAI---QQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATE 1368
Query: 1554 IQKHVSFASD--TKQGRDEQLDNTMNKELLDAVPRAELDL 1591
++K +D TK + ++ N ++L + + +L
Sbjct: 1369 LEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL 1408
Score = 58.8 bits (136), Expect = 1e-07
Identities = 173/971 (17%), Positives = 398/971 (40%), Gaps = 77/971 (7%)
Query: 158 LSVLQVKMKIMETTILDLQEKI-NEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQ 216
+ VLQ + + +L ++ ++ NEK++ E NK ++ +Q
Sbjct: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELSLSEKKNLTLSKEVQQ 895
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLA 275
+Q N+ AE +K + ++ E K +++S+ +E A + + +I L H+K+
Sbjct: 896 ----IQSNYDIAIAELHVQKSKN-QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKI- 949
Query: 276 QELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLN 335
EL L S + E+ + L++ L K ++ E+
Sbjct: 950 DELRTLDSVSQISNIDLLNLRDLS---NGSEEDNLPNT-QLDLLGNDYLVSK-QVKEY-- 1002
Query: 336 CQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+I++ N+E + + + E K + S K S I + K+++ E
Sbjct: 1003 -RIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ--IEKLQAEVKGYKDEN 1059
Query: 394 LNQDTDKKINKNEIAK-LEMVIQSLNKDLVDKEYV----ISEKDTXXXXXXXXXXGKDTL 448
+ N++++ K E +IQ L ++L +K I G
Sbjct: 1060 NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY 1119
Query: 449 IAQL-QLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLKQ---ELNDEIKDVNVKD 500
A++ +LE + H +D+ E I K++ LK+ L D +K N KD
Sbjct: 1120 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK--NTKD 1177
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
L K +E+ITQL + + K+++++K + +Q + + ++S S+ L
Sbjct: 1178 LNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNL 1234
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKAISLL 619
+L + A+L+E+ + + + + D K + I++ L + + +
Sbjct: 1235 KADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC---- 1290
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSE--IKSVHLEEQIDALSASKKE 677
SQ+ D+ Q +QQ +++ ++ + + Q ++ C + +K +E+ L ++
Sbjct: 1291 -SQELDMKQRT--IQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1347
Query: 678 LALVIENLKLDKEQLYGTIKDLE------NDKEDIMNKLQNYIQEN-MDLTDKLEKMSAE 730
+ L+ E++ +LE ND E N+ N EN D+ KL + E
Sbjct: 1348 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1407
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+ E K N + + ++ + + + +E R+ ++ + ++ + +E A
Sbjct: 1408 -LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTA 1466
Query: 787 VMEDRRYSLER---KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ ++ L++ + DQL + L+ + KA +Q+D + +L ++ +E Q+++
Sbjct: 1467 QLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMD 1526
Query: 844 IEHENKELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY-----Q 897
I+ + +++ E + + +IS + ++ ++V + +ST++ +
Sbjct: 1527 IKPKRISSADPDKLQTEPLSTSFEISRNKIED--GSVVLDSCEVSTENDQSTRFPKPELE 1584
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
Q L+ N + H T V K + + + N E ++ + N N+++
Sbjct: 1585 IQFTPLQPNKMAVKHPGCTTPVTVKIP-KARKRKSNEMEEDLVKCENKKNATPRTNLKFP 1643
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ K + + ++ + + V + +++ + + ++
Sbjct: 1644 ISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSI 1703
Query: 1018 LKQKDEEIIAL--NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
L+ K ++II + K++N + S ++ +K +T+++ + + +V L+D K
Sbjct: 1704 LQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVI--LMDQK 1761
Query: 1076 QHNEELQILVR 1086
+ QI+ R
Sbjct: 1762 MKESDHQIIKR 1772
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 1167 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 1225
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 1226 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 1281
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 1282 ELEKKKNQCSQELD 1295
>AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 95.5 bits (227), Expect = 1e-18
Identities = 213/1093 (19%), Positives = 454/1093 (41%), Gaps = 84/1093 (7%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
K + + + N K +NVK +++ E + + D ++ KL +
Sbjct: 497 KSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDED 556
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY 599
+ KT++ +K S++E +L + + L +K+ ++EK L+ + + + + Y
Sbjct: 557 LDKTLEE-NKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQ---Y 612
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI--SQLQSDQV-- 655
E + ET L+ +LE + L K D E+ DI +++++++
Sbjct: 613 WAQREAD-FKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATA 671
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
C E+K ++ + L+ +K EL E LK + + I++LE + I+ + Q I+
Sbjct: 672 CLELKFNQIKAE---LAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQR-IK 727
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQS-KIQTQFGIDAKIQERDLYIENIESELSKY 774
E +++ D+ E + I+E +H E + K + + I L
Sbjct: 728 ELINIIDQKE----DTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDS 783
Query: 775 KSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
KS+IC + + E ++ K + S + E QK E E+ + + VL +
Sbjct: 784 KSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIED-IRVLQE 842
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
++ + LL IE+E K + EE L + QQ + L EK N T E +
Sbjct: 843 NNEGLRAFLLTIENELKNEK-------EEKAELNKQIVHFQQELS-LSEKKNLTLSKEVQ 894
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IESAIRDKKVLNEKYE 951
+ + E ++++ ++ Q + K EIE T+ I + + K+++ K +
Sbjct: 895 QIQSNYDIAIAELHVQKSKNQEQEEKIMKLSN----EIETATRSITNNVSQIKLMHTKID 950
Query: 952 --KNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKM-NLELIDKHVQKQQTQSPDYT 1004
+ ++ V+Q+ L++ N E N+ +L+ + N L+ K V++ + Q P+
Sbjct: 951 ELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRE 1010
Query: 1005 EQYINEINKL----NALLK---QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK- 1056
+ + I + ++K +K +I L Q+I Q D ++L + K
Sbjct: 1011 NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY-KDENNRLKEKEHKN 1069
Query: 1057 LENMEEEMQRVSKQLLDSKQH-NEELQILVR---EQDDQIKELKETKLTFEMNIPKTEGM 1112
+++ +E + + +QL + Q N L + ++ E + EL + ++ I + E +
Sbjct: 1070 QDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETI 1129
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER----SVLQEQSAKLNTEL 1168
+ + +E D ++E +E +Q+ L + KL E+
Sbjct: 1130 LETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEI 1189
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + ++ L + N+++ +LK +L + NL A+L+
Sbjct: 1190 TQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK---ADLQRKEEDYA 1246
Query: 1229 DQRGFEIAELWKQ-HLAQREADFQKTEHEL-RVQLSAFESKYEQL---LDSVQSSTQ--- 1280
D + ++ + KQ Q+E + E +L R++++ E K Q LD Q + Q
Sbjct: 1247 DLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLK 1305
Query: 1281 EETNKIVTMEQVTSLQNKLQD---KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXX 1337
E+ N E + + +D KE+ + +++ + Q ++ + ++ + K+
Sbjct: 1306 EQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ-EQTQVEQDQVLEAKLEEVER 1364
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
DL T+N + ++ ++ + L+ R
Sbjct: 1365 LATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNADRKKW 1422
Query: 1398 AEAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYE 1454
E K++ +T E +++ E+ + + Q+N E E + QL E + ++ E
Sbjct: 1423 LEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN-EMEILTAQLTEKDSDLQKWREE 1481
Query: 1455 KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE 1514
++ +A L +++ A +QK++EIE++K I KI E+ ++ + ++ A +
Sbjct: 1482 RDQLVAALEIQL--KALISSNVQKDNEIEQLKRIISETSKI-ETQIMDIKPKRISSA-DP 1537
Query: 1515 EVAKTNEMQTALE 1527
+ +T + T+ E
Sbjct: 1538 DKLQTEPLSTSFE 1550
Score = 83.0 bits (196), Expect = 8e-15
Identities = 184/963 (19%), Positives = 385/963 (39%), Gaps = 100/963 (10%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK-----EDIMNKLQNYIQENM 718
+EE +A E L+ E+L E+ I E K ED+ KL N +E +
Sbjct: 536 VEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL 595
Query: 719 DLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
L K+ + ++ ++ A+ E K + +QER++ EN E L+ +K +
Sbjct: 596 TLEFKIREEVTQEFTQYWAQ--READFK-------ETLLQEREILEENAERRLAIFKDLV 646
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEK-QKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+ + +D + + + ++ + L+ K + +E + EL+ L +
Sbjct: 647 GKCDTREEAAKDI-CATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENES 705
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT----DLAESES 893
+ + E+E NK++ +NQ ++E N+ D + L T D A++ S
Sbjct: 706 DSLIQELETSNKKIITQNQ-RIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSS 764
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT--------QIESAIRDKKV 945
+L + + + + ++ I ++K + + E++ + + SAI + +
Sbjct: 765 LIINNKL--ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQK 822
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+E+ NI + + LQE + + +E N++ E +K +Q + +
Sbjct: 823 KSEEVRPNIAEIEDIRV-LQENNEGLRAFLLTIE--NELKNEKEEKAELNKQIV---HFQ 876
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYM-SMVSDYESKLAQFTTKLENMEEEM 1064
Q ++ K N L ++ ++I + N I A++ S + E K+ + + ++E +
Sbjct: 877 QELSLSEKKNLTLSKEVQQIQS-NYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 1065 QRVSKQLLDSKQHNEELQILVR-EQDDQIKELKETKLTF---EMNIPKTE-GMIISSTIE 1119
Q+ +EL+ L Q I L L+ E N+P T+ ++ + +
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLV 995
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEE-EEFIQERSVLQEQSAKLNTELQECYTKIIQL 1178
+ + EE +E ++ S Q +L ++++ ++
Sbjct: 996 SKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 1179 ETLNTELTGHDVVNQEQ--------INQLKSKLEQLNTENDNLLSTVAELRSSISSAVD- 1229
+ N L + NQ+ I QLK +L++ N D + V E + ++S
Sbjct: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQG 1115
Query: 1230 -----------QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
+ E ++ H A+ E D + E + + E L DSV+++
Sbjct: 1116 VTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
++ E++T L N LQD +HL L+E+ + Q E EK+
Sbjct: 1176 KDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ--------ETEKL--KEEL 1224
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DL+ + + Y ++E+ + + ++ Q++K ++N+
Sbjct: 1225 SASSARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQKEVSVMRDEDKLLRIKINEL 1283
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
E K + + +L++K I Q Q N+ + V + + +YE+ +DL KE
Sbjct: 1284 EKKKNQCSQELDMKQRTIQQLKE-------QLNN--QKVEEAIQQYERACKDLNV-KEKI 1333
Query: 1459 LAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAK 1518
+ +R+ + E +T ++ ++ KL EE+ TE ++ +L + K
Sbjct: 1334 IEDMRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATELEKWKEKCNDLETKNNQRSNK 1389
Query: 1519 TNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK-IQKHVSFASDTKQGRDEQLDNTMN 1577
+E T + ++ L DE+ + A K +++ + + K+ +N N
Sbjct: 1390 EHENNTDVLG---KLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEA-----ENIRN 1441
Query: 1578 KEL 1580
KE+
Sbjct: 1442 KEM 1444
Score = 77.8 bits (183), Expect = 3e-13
Identities = 176/940 (18%), Positives = 381/940 (40%), Gaps = 81/940 (8%)
Query: 380 SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+++K+ ++ E + + K +NE L +++ NK ++ + I E
Sbjct: 678 NQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKE 737
Query: 440 XXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK 499
L + ++ + + + + + N NE +V + K ++ E K VN
Sbjct: 738 DTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNEN 797
Query: 500 DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
+L + A++ ++ I K +V+ N + +++ +V N E +R
Sbjct: 798 ELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPN----IAEIEDI-----RVLQENNEGLR 848
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L + ++ +EEK L +V + + E +NL T K + +
Sbjct: 849 AF--LLTIENELKNEKEEKAELNKQIVHFQQELSLS--------EKKNL--TLSKEVQQI 896
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADIS---QLQSDQVCSEIKSVHL-EEQIDALSASK 675
+S + ELH+ + K E E+K+ +S + + + + + + L +ID L
Sbjct: 897 QSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLD 956
Query: 676 KELALVIENLKLDKEQLYGTIKD-LENDKEDIMNKLQNYIQENMDLTDKLEKMSAE-KIS 733
+ +L ++ G+ +D L N + D++ +Y+ ++++ + E
Sbjct: 957 SVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLG--NDYLVSKQVKEYRIQEPNRENSFH 1014
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRR 792
+ I E + ++ +I+E + IE +++E+ YK RL E+ +D
Sbjct: 1015 SSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLL 1074
Query: 793 YSLERKADQLGSYLQEKQKAYS---EYTIQEDELVNRL--------AVLMDHDRVVEKQL 841
E QL LQEK ++ ++ ++ L A + + + ++E Q
Sbjct: 1075 KEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQK 1134
Query: 842 LEIEHENK---ELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+E H K ++ +K I+L+ +NL+ + Q+H V+ ++ E + + T
Sbjct: 1135 VECSHSAKLEQDILEKESIILKLERNLK----EFQEHLQDSVKNTKDLNVKELKLKEEIT 1190
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QL + ++K + + ++E E L+ E + S+ R + + + K +Y
Sbjct: 1191 QLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSA---SSARTQNLKADLQRKEEDY-A 1246
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L+ +L + K I+ + +E++ M E DK ++ + + Q E++ +
Sbjct: 1247 DLKEKLTDAKKQIKQVQ---KEVSVMRDE--DKLLRIKINELEKKKNQCSQELDMKQRTI 1301
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSD--YESKLAQFTTKLENMEEEMQRVSKQLLDSK- 1075
+Q E++ NQK+ A Y D + K+ + +E+ Q Q+L++K
Sbjct: 1302 QQLKEQL--NNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKL 1359
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+ E L + + ++ +L ETK N + + + D+ +
Sbjct: 1360 EEVERLATELEKWKEKCNDL-ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNAD 1418
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ-- 1193
K+ + + ++ ++ K + + + + ++E L +LT D Q
Sbjct: 1419 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1478
Query: 1194 -EQINQLKSKLE-QL------NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
E+ +QL + LE QL N + DN + + + S S Q I ++ + ++
Sbjct: 1479 REERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQ----IMDIKPKRISS 1534
Query: 1246 READFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEE 1282
+ D +TE L +K E +LDS + ST+ +
Sbjct: 1535 ADPDKLQTE-PLSTSFEISRNKIEDGSVVLDSCEVSTEND 1573
Score = 65.7 bits (153), Expect = 1e-09
Identities = 199/1000 (19%), Positives = 422/1000 (42%), Gaps = 106/1000 (10%)
Query: 636 KYDEVEDKLADISQLQSDQ--VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K+ + K+ L S Q + +KS + +D+ S SK I N+K
Sbjct: 471 KFSAIAQKVCVPDTLNSSQEKLFGPVKSSQ-DVSLDSNSNSK------ILNVKRATISWE 523
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKINHEEQSKIQTQFG 752
+++DL D ED++ +L+N +E ++ KL +K + E A I+HEE+ K+
Sbjct: 524 NSLEDLMED-EDLVEELEN-AEETQNVETKLLDEDLDKTLEENKAFISHEEKRKL----- 576
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESI---AVMEDRRYSLERKADQLGSYLQEK 809
DL IE+++ +L K LE I E +Y +R+AD + LQE+
Sbjct: 577 -------LDL-IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQER 628
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ I E+ RLA+ D L + + +E K+ + + +
Sbjct: 629 E-------ILEENAERRLAIFKD---------LVGKCDTREEAAKD--ICATKVETEEAT 670
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN--LKRITHEHQTLIVQKKKEIED 927
+ ++ +N + + +T E TK + + R+ ES+ ++ + ++ +I Q ++ I++
Sbjct: 671 ACLELKFNQIKAELAKTK-GELIKTKEELKKRENESDSLIQELETSNKKIITQNQR-IKE 728
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN-IENLNMNVEELNKMNL 986
L I Q E I + + L E + + + N I N + V + +K +
Sbjct: 729 L-INIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKI 787
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALL--KQKDEEIIALNQKINNAQVSYMSMVS 1044
K V + + Q D I+ +A+ ++K EE+ +I + +V
Sbjct: 788 CSERKRVNENELQQ-DEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRV-LQENNE 845
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH---NEELQILVREQDDQIKELKETKLT 1101
+ L +L+N +EE ++KQ++ +Q +E+ + + ++ QI+ + +
Sbjct: 846 GLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIA 905
Query: 1102 FEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS 1161
E+++ K++ I +S N ++ +K+ + I E L S
Sbjct: 906 -ELHVQKSKNQEQEEKIMKLS---NEIETATRSITNNVSQIKLMHTK--IDELRTLDSVS 959
Query: 1162 AKLNTELQECY-----TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND--NLL 1214
N +L ++ L +L G+D + +Q+ + ++++ N EN + +
Sbjct: 960 QISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEY--RIQEPNRENSFHSSI 1017
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFESKYEQLLD 1273
+ E I A ++ +I EL +Q Q E K E+ R++ +++ + L +
Sbjct: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENN-RLKEKEHKNQDDLLKE 1076
Query: 1274 S---VQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q +E K VT++ +Q+ ++ K L L + +I+ L + +E +
Sbjct: 1077 KETLIQQLKEELQEKNVTLD--VQIQHVVEGKRA-LSELTQGVTCYKAKIKELETILETQ 1133
Query: 1331 KVAFXXXXXXXXXXXXXXXXDLRTEN--QSYKQMQEQSILN---INEENAQLKK--SSXX 1383
KV L+ E + +++ + S+ N +N + +LK+ +
Sbjct: 1134 KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT 1193
Query: 1384 XXXXXXXXXXRVNDAEAKV-LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
++ + E + + T +L+ + S +T L ++ +++ +++++L
Sbjct: 1194 NNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLT 1253
Query: 1443 EYEKRIEDLTYE---KESELAILRLKMHE-----NANHYETMQKESEIERVKLIEEL-NV 1493
+ +K+I+ + E E +LR+K++E N E K+ I+++K E+L N
Sbjct: 1254 DAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLK--EQLNNQ 1311
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
K+ E++ +Q K L + +M+ LE QE V + + V +++
Sbjct: 1312 KVEEAI---QQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATE 1368
Query: 1554 IQKHVSFASD--TKQGRDEQLDNTMNKELLDAVPRAELDL 1591
++K +D TK + ++ N ++L + + +L
Sbjct: 1369 LEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL 1408
Score = 58.8 bits (136), Expect = 1e-07
Identities = 173/971 (17%), Positives = 398/971 (40%), Gaps = 77/971 (7%)
Query: 158 LSVLQVKMKIMETTILDLQEKI-NEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQ 216
+ VLQ + + +L ++ ++ NEK++ E NK ++ +Q
Sbjct: 837 IRVLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELSLSEKKNLTLSKEVQQ 895
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLA 275
+Q N+ AE +K + ++ E K +++S+ +E A + + +I L H+K+
Sbjct: 896 ----IQSNYDIAIAELHVQKSKN-QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKI- 949
Query: 276 QELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLN 335
EL L S + E+ + L++ L K ++ E+
Sbjct: 950 DELRTLDSVSQISNIDLLNLRDLS---NGSEEDNLPNT-QLDLLGNDYLVSK-QVKEY-- 1002
Query: 336 CQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+I++ N+E + + + E K + S K S I + K+++ E
Sbjct: 1003 -RIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ--IEKLQAEVKGYKDEN 1059
Query: 394 LNQDTDKKINKNEIAK-LEMVIQSLNKDLVDKEYV----ISEKDTXXXXXXXXXXGKDTL 448
+ N++++ K E +IQ L ++L +K I G
Sbjct: 1060 NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY 1119
Query: 449 IAQL-QLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLKQ---ELNDEIKDVNVKD 500
A++ +LE + H +D+ E I K++ LK+ L D +K N KD
Sbjct: 1120 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK--NTKD 1177
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
L K +E+ITQL + + K+++++K + +Q + + ++S S+ L
Sbjct: 1178 LNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNL 1234
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKAISLL 619
+L + A+L+E+ + + + + D K + I++ L + + +
Sbjct: 1235 KADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC---- 1290
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSE--IKSVHLEEQIDALSASKKE 677
SQ+ D+ Q +QQ +++ ++ + + Q ++ C + +K +E+ L ++
Sbjct: 1291 -SQELDMKQRT--IQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1347
Query: 678 LALVIENLKLDKEQLYGTIKDLE------NDKEDIMNKLQNYIQEN-MDLTDKLEKMSAE 730
+ L+ E++ +LE ND E N+ N EN D+ KL + E
Sbjct: 1348 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1407
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+ E K N + + ++ + + + +E R+ ++ + ++ + +E A
Sbjct: 1408 -LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTA 1466
Query: 787 VMEDRRYSLER---KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ ++ L++ + DQL + L+ + KA +Q+D + +L ++ +E Q+++
Sbjct: 1467 QLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMD 1526
Query: 844 IEHENKELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY-----Q 897
I+ + +++ E + + +IS + ++ ++V + +ST++ +
Sbjct: 1527 IKPKRISSADPDKLQTEPLSTSFEISRNKIED--GSVVLDSCEVSTENDQSTRFPKPELE 1584
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
Q L+ N + H T V K + + + N E ++ + N N+++
Sbjct: 1585 IQFTPLQPNKMAVKHPGCTTPVTVKIP-KARKRKSNEMEEDLVKCENKKNATPRTNLKFP 1643
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ K + + ++ + + V + +++ + + ++
Sbjct: 1644 ISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSI 1703
Query: 1018 LKQKDEEIIAL--NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
L+ K ++II + K++N + S ++ +K +T+++ + + +V L+D K
Sbjct: 1704 LQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVI--LMDQK 1761
Query: 1076 QHNEELQILVR 1086
+ QI+ R
Sbjct: 1762 MKESDHQIIKR 1772
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 1167 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 1225
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 1226 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 1281
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 1282 ELEKKKNQCSQELD 1295
>D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein.
Length = 709
Score = 95.1 bits (226), Expect = 2e-18
Identities = 132/647 (20%), Positives = 299/647 (46%), Gaps = 60/647 (9%)
Query: 471 NTEDVNEIA--KVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLNDEIDA----- 521
N E+V ++ +V + ++++ +K++ ++K LI++ E I +L++E D
Sbjct: 91 NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 150
Query: 522 -ANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
A+ + + +K + ++ + +++D+ +I RL +EL ++++ + ++E
Sbjct: 151 HASSSAQSPCGSPGMKRTESRQHLS--VELADAKAKIRRLRQELEEKTEQLLDCKQELEQ 208
Query: 581 LQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+++ L M + SD + + L R KA+ + + L E+ +++ +
Sbjct: 209 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK-----LESEVSRYKERLHD 263
Query: 640 VEDKLADISQLQSD-QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
+E A + +L+ D QV E K++ LE+Q++ A +L L+ + QL + D
Sbjct: 264 IEFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKL----HELEKENLQLKAKLHD 318
Query: 699 LENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL---LAKINHEEQSKIQTQFGIDA 755
+E +++ K++ ++ENM L + +K S ++ L L +I+ + Q +
Sbjct: 319 MEMERDMDRKKIEELMEENMTL-EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 377
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
++ E S L K + L +++ + S+E A ++ +E Q+ +
Sbjct: 378 EVNEL------TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 431
Query: 816 YTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ-Q 874
I E+E+V L + + K L++ E +L+K + L EN QI + + + +
Sbjct: 432 VEILENEIVQEKQSLQNCQN-LSKDLMK---EKAQLEKTIE-TLRENSERQIKILEQENE 486
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
H N V + L + + +++D+E +I HE I + ++ +E E
Sbjct: 487 HLNQTV-----SSLRQRSQISAEARVKDIEKE-NKILHES---IKETSSKLSKIEFE-KR 536
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
QI+ + K E+ E+ + LE + + + I NL + E++ + E + ++
Sbjct: 537 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE--NSELE 594
Query: 995 KQQTQSPDYTEQYINEINKLNALLK---QKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
++ + + + N +L +L K Q DEE + L + + + + + M M ++L
Sbjct: 595 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM-----AQLQ 649
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
+LE+ +E++++ + L S + E L++ + D + + L++T
Sbjct: 650 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 696
Score = 80.6 bits (190), Expect = 4e-14
Identities = 119/580 (20%), Positives = 245/580 (42%), Gaps = 44/580 (7%)
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
+Q I+ ++ L+++ + E ++ I L E + ++ GS +
Sbjct: 107 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 166
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ ++ +++ + ++ L +QLL+ + E ++++ + + L +EN NL
Sbjct: 167 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 226
Query: 869 LSDMQQH---YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
+ + +AL EKA R D ESE ++Y+ +L D+E R V++ KE
Sbjct: 227 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR---------VEELKED 277
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL--NK 983
+ +E T +E + + ++K + + QL+A+L + + + +EEL
Sbjct: 278 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 337
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL-NQKINNAQVSYMSM 1042
M LE+ K + EQ A K E+ L + ++ ++ S+
Sbjct: 338 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 397
Query: 1043 VSDYE------SKLAQFTTKLENMEEEMQRVSK--QLLDSK--QHNEELQILVREQDDQI 1092
E + +K+ ME+E QR+SK ++L+++ Q + LQ D +
Sbjct: 398 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 457
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
KE + + T E +E I +E ++ N +V++ E +
Sbjct: 458 KEKAQLEKTIETLRENSERQI--KILEQENEHLNQTVSSLRQRSQISAEARVKDIE---K 512
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E +L E + +++L + + + EL H E+ +L+++L L EN+
Sbjct: 513 ENKILHESIKETSSKLSKIE---FEKRQIKKELE-HYKEKGERAEELENELHHLEKENEL 568
Query: 1213 LLSTVAELRSSIS--SAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
L + L+ + A++Q E+ E + L + F+ L QL + E + Q
Sbjct: 569 LQKKITNLKITCEKIEALEQENSEL-ERENRKLKKTLDSFK----NLTFQLESLEKENSQ 623
Query: 1271 L-LDSVQSSTQEETNKIVTMEQV-TSLQNK-LQDKEEHLR 1307
L ++++ E+ K +M+ L+NK L+ ++E L+
Sbjct: 624 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 663
Score = 61.7 bits (143), Expect = 2e-08
Identities = 122/543 (22%), Positives = 217/543 (39%), Gaps = 69/543 (12%)
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI-LVREQDDQIKELKETKLTFEMNIP 1107
+LA K+ + +E++ ++QLLD KQ E+++I L R Q + + L + +
Sbjct: 177 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR-------- 228
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-----EEEFIQERSVLQEQSA 1162
+ ++ + + A VD L E EE ++ VL E
Sbjct: 229 --SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 286
Query: 1163 KLNTELQECYT---KIIQLETLNTELTG--HDVVNQEQINQLKSKLEQLNTEN------- 1210
L +L+ K+ +LE N +L HD+ + ++ + K+E+L EN
Sbjct: 287 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD--RKKIEELMEENMTLEMAQ 344
Query: 1211 ----DNLLSTVAEL----RSSISSAVDQR--GFEIAELWKQHLAQREADFQ---KTEHEL 1257
D L EL R+S S Q+ G E+ EL L + E + Q KT EL
Sbjct: 345 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 404
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADV 1316
R + + E ++L ++ Q + K+ +E ++ + LQ+ + ++L ++ A +
Sbjct: 405 RTTVDSVEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 463
Query: 1317 INQIEILRSEIEDE-KVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILN--INE 1372
IE LR E + K+ + K ++ E IL+ I E
Sbjct: 464 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 523
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAE-AKVLELT-HQLELKDSEIYQK-------THEY 1423
+++L K E A+ LE H LE K++E+ QK T E
Sbjct: 524 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE-KENELLQKKITNLKITCEK 582
Query: 1424 TITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIE 1483
L Q N E E ++L + ++LT++ ES L+ + E ++ +E
Sbjct: 583 IEALEQENSELERENRKLKKTLDSFKNLTFQLES------LEKENSQLDEENLELRRNVE 636
Query: 1484 RVKLIEELNVKI-TESVSLNKQVAELNKALE---EEVAKTNEMQTALENQEIEIVTLNDE 1539
+K ++ E+ L + +L K LE KT ++ + + +IE L
Sbjct: 637 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 696
Query: 1540 ITN 1542
+ N
Sbjct: 697 LEN 699
Score = 52.4 bits (120), Expect = 1e-05
Identities = 73/356 (20%), Positives = 155/356 (43%), Gaps = 24/356 (6%)
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
S S+ ++L + ++ + + + KLEM QSL K + + + +
Sbjct: 365 SELSEAPQKSLGHEVNE-LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 423
Query: 444 GKDTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
L +++ LE++ E SL + ++D+ + K Q + E E + +K L
Sbjct: 424 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMK-EKAQLEKTIETLRENSERQIKILE 482
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLT 561
++ + + ++ L + + +K ++ +K+ + +++T SK+ ++I +
Sbjct: 483 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 542
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
E ++ ELE E +L+ E+++ +K I NL T + I LE
Sbjct: 543 EHYKEKGERAEELENELHHLEK-----------ENELLQKKI--TNLKIT-CEKIEALEQ 588
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS-ASKKELAL 680
+ +L +E L++ D ++ + L+ + + +++ L +++L AS K L
Sbjct: 589 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 648
Query: 681 VIEN--LKLDKEQLYGTIKDLE---NDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
+EN L+ +KEQL ++ L+ E + Q EN L LE + +K
Sbjct: 649 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKK 704
Score = 43.2 bits (97), Expect = 0.008
Identities = 109/498 (21%), Positives = 197/498 (39%), Gaps = 53/498 (10%)
Query: 1142 LKVQEEEEFIQERSVLQ-EQSAKLNTELQEC---YTKIIQLETLN-TELTGHDVVNQEQI 1196
++ Q++EEFI+ L + A + +QE + L+ + T+++ D+ + +
Sbjct: 58 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDI--EPLL 115
Query: 1197 NQLKSKLEQLNTENDNLLSTVAELR-------------SSISSAVDQRGFEIAELWKQHL 1243
+ L++L E D T+ EL SS S G + E +QHL
Sbjct: 116 KNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTES-RQHL 174
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN-KIVTMEQVTSLQNKLQDK 1302
+ AD + LR +L E K EQLLD Q Q E K + E + L + +
Sbjct: 175 SVELADAKAKIRRLRQEL---EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 231
Query: 1303 --EEHLRNLQEKYADVIN-QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRT--ENQ 1357
+ L L+EK V + E+ R + + F + +T E+Q
Sbjct: 232 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 291
Query: 1358 -SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA--EAKVLELTHQLELKDS 1414
+ + + + +EN QLK ++ + E LE+ + + +S
Sbjct: 292 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 351
Query: 1415 -------EIYQKTHEYTITLTQR--NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
E +T E + + ++ E +L++ E + LT E EL
Sbjct: 352 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE-ELRTTVDS 410
Query: 1466 MHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNE-MQT 1524
+ NA+ M+KE++ K +E L +I + + L+K L +E A+ + ++T
Sbjct: 411 VEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 469
Query: 1525 ALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAV 1584
EN E +I L E +L V SS + + +S + K E NK L +++
Sbjct: 470 LRENSERQIKILEQENEHLNQTV--SSLRQRSQISAEARVKDIEKE------NKILHESI 521
Query: 1585 PRAELDLAMYMLHQRDVR 1602
L+ +R ++
Sbjct: 522 KETSSKLSKIEFEKRQIK 539
Score = 39.1 bits (87), Expect = 0.13
Identities = 65/297 (21%), Positives = 141/297 (47%), Gaps = 29/297 (9%)
Query: 295 LAKQSIEPSCEE-KTEIE--EKGSLEIANMTE----LTKKIELLEHLNCQIRQT------ 341
+ QS+ + EE +T ++ E + +I M + L+KK+E+LE+ Q +Q+
Sbjct: 392 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 451
Query: 342 -NKELENKLATMGTESKAVSSPSKKGSPLISRKSG--RNTASKMKSPWSQLSSETLNQDT 398
+K+L + A + + + S++ ++ +++ T S ++ SQ+S+E +D
Sbjct: 452 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR-SQISAEARVKDI 510
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
+K+ NK ++ L+K +K + E + ++ L LE +
Sbjct: 511 EKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL---HHLEKEN 566
Query: 459 HMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV--NVKDLIEKLKSAEEQITQLN 516
+ + ++ E + + + +L++E N ++K + K+L +L+S E++ +QL+
Sbjct: 567 ELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLEKENSQLD 625
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAE 573
+E +N+ +K +K+ Q+Q ++N K +S KE ++ EL S K E
Sbjct: 626 EENLELRRNVESLKC-ASMKMAQLQ--LEN--KELESEKEQLKKGLELLKASFKKTE 677
Score = 37.9 bits (84), Expect = 0.30
Identities = 44/205 (21%), Positives = 85/205 (41%), Gaps = 10/205 (4%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIE--SKDVRISSLEEANKLLEAARFEISLE 270
+T ++ ++ Q + E E ++ L+ S + R+ +E+ NK+L + E S +
Sbjct: 468 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 527
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
SK+ E E+ + +E + E +I N+ +KIE
Sbjct: 528 LSKI--EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 585
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR--KSGRNTAS----KMKS 384
LE N ++ + N++L+ L + + + S K+ S L + RN S MK
Sbjct: 586 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 645
Query: 385 PWSQLSSETLNQDTDKKINKNEIAK 409
QL ++ L + ++ E+ K
Sbjct: 646 AQLQLENKELESEKEQLKKGLELLK 670
>AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1454
Score = 95.1 bits (226), Expect = 2e-18
Identities = 216/1154 (18%), Positives = 501/1154 (43%), Gaps = 104/1154 (9%)
Query: 221 MQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQ 280
++E I +EAE + ++L++ E+K LE++ K++ E SL+ SK +E +
Sbjct: 171 LEEQIINLEAE-VSAQDKVLREAENK------LEQSQKMV--IEKEQSLQESK--EECIK 219
Query: 281 XXXXXXXXXXXXXXLAKQSIEP--SCEEKTEIEEKGSLEIANMTELTK-KIELLEHLNCQ 337
+Q E + EE ++ ++ ++A E + + E+LE
Sbjct: 220 LKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTN 279
Query: 338 IRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQD 397
+ NK L+ + +E + + ++ ++ N K++ + +SE + Q
Sbjct: 280 CEKENKRLQERCGLYKSELEILKEKLRQ-----LKEENNNGKEKLRI-MAVKNSEVMAQL 333
Query: 398 TDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQ 457
T+ ++ I KLE +++ ++ L DK +++E D + Q ++E
Sbjct: 334 TE---SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLD--LCQQEIESS 388
Query: 458 QHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLND 517
+ +E SL + + E+ + L + + + I ++ + I++L
Sbjct: 389 R-VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDR-CIGCCEANKLVISELRI 446
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
++ + K+ +N L Q+ +++ + +S+K TE + +V ++++
Sbjct: 447 KLAIKEAEIQKLHAN--LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQ 504
Query: 578 KGNLQLHLVDYDSGRMIES--DVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + R++ ++ K+I++E + LK + +F L+QE
Sbjct: 505 NQHTMNKQYEKERQRLVTGIEELRTKLIQIE-AENSDLKVNMAHRTSQFQLIQE------ 557
Query: 636 KYDEVEDKLADISQLQSDQV--CSEIKSVH--LEEQIDALSASKKELALVIENLKLDKEQ 691
E+ +K ++ S+L+S+ CS++ ++ LEE+I A S+ + A + + L E+
Sbjct: 558 ---ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEK 614
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
+ ++ + E I + + +++ ++EK E++ L K + + + + +T
Sbjct: 615 IRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQ-IERLEAQLEKKDQQFKEQEKTMS 673
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ I + ++E+++ L++ K + + E++ E +L+ +Q+ + ++
Sbjct: 674 MLQQDIICKQHHLESLDRLLTESKGEMKK--ENMKKDE----ALKALQNQVSEETIKVRQ 727
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE----NKELQKKNQILLEENQNLQI 867
S I ++ELV L L + EKQL + E KEL+ KN L E ++ I
Sbjct: 728 LDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVI 787
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE- 926
+QQ L ++ R E TK + Q+ LE L++ + + +++ E
Sbjct: 788 LQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCES 847
Query: 927 -----DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
DL+ + ++ R K+ ++Y+ E ++++E ++ K + EN M++ +L
Sbjct: 848 AAHEADLKRQKVIELTGTARQVKIEMDQYK---EELSKMEKEIMHLKRDGENKAMHLSQL 904
Query: 982 N------------KMN----LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI 1025
+ K N LE + + + T++ E E+ + LK ++
Sbjct: 905 DMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQL 964
Query: 1026 IALNQKINNAQVSY---MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
L + AQ+S + + D ++L + ++E+ ++E+ + + L K+ N EL+
Sbjct: 965 QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL---KERNWELK 1021
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
+ ++E + E I K EG + S +E + + ++ L
Sbjct: 1022 QRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELE-LKECNKQIESLNDKLQNAKEQL 1080
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
+ E+EFI ++ +++ ++L E++ ++ ++E++ E + ++ L +
Sbjct: 1081 R---EKEFIMLQN--EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1135
Query: 1203 LEQLNTENDNLLSTVAELRSSISSA---VDQRGFEIAELWKQHLAQREADFQKTEHEL-- 1257
L + N + +AE R A +++ E+ ++ KQ +++A EL
Sbjct: 1136 LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDM-KQLSKEKDAHGNHLAEELGA 1194
Query: 1258 -RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+V+ + E++ + + + S+ E + ME ++ +N + K + Q+
Sbjct: 1195 SKVREAHLEARMQAEIKKL-SAEVESLKEAYHMEMISHQENHAKWKIS--ADSQKSSVQQ 1251
Query: 1317 IN-QIEILRSEIED 1329
+N Q+E + E+E+
Sbjct: 1252 LNEQLEKAKLELEE 1265
Score = 94.7 bits (225), Expect = 2e-18
Identities = 214/1097 (19%), Positives = 450/1097 (41%), Gaps = 118/1097 (10%)
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK-TIDNFSKVSDSNKEIVRLTEELHHL 567
EEQI L E+ A +K + + ++ KL+Q QK I+ + +S +E ++L +L
Sbjct: 172 EEQIINLEAEVSAQDKVLREAEN----KLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 227
Query: 568 SQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
+++ E ++ + + + + V +K+ +++ E + ++ E + L
Sbjct: 228 TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRL 287
Query: 627 VQELHILQQKYDEVEDKLADISQLQSD-QVCSEIKSVHLEEQIDALSASKKELALVIENL 685
+ + + + + +++KL + + ++ + I +V E + L+ S++ + L
Sbjct: 288 QERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI------L 341
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
KL+ E LEN K++I+ + + EN +L ++ + E++ +I
Sbjct: 342 KLESE--------LEN-KDEILRDKFSLMNENRELKVRVAAQN-ERLDLCQQEIESSRVE 391
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYK-SRICRLEES-IAVMEDRRYSLERKADQLG 803
+ I +R+L+ +S LSKY+ S E+ I E + + +L
Sbjct: 392 LRSLEKIISQLPLKRELF--GFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 449
Query: 804 SYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQ 863
E QK ++ T ++L L D +L +E E +L +Q+ ++Q
Sbjct: 450 IKEAEIQKLHANLTA--NQLSQSLITCNDSQE--SSKLSSLETEPVKLGG-HQVESVKDQ 504
Query: 864 NLQISLSDMQQHYNALVEKAN--RTDLAESESTKYQTQLRDLESNLKRITHEHQTL---I 918
N ++ LV RT L + E+ DL+ N+ T + Q + +
Sbjct: 505 NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAEN-----SDLKVNMAHRTSQFQLIQEEL 559
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEK---YEKNIEYVTQLEAQLQEYKNNIENLN 975
++K LE E + + +K L EK Y +LE +L E I +L
Sbjct: 560 LEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLE 619
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
N+ ++ +K + Q + +Q I +L A L++KD++ + ++
Sbjct: 620 TNINTEHEKICLAFEKAKKIHLEQHKEMEKQ----IERLEAQLEKKDQQFKEQEKTMSML 675
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
Q + ES T M++E + + L + E I VR+ D ++
Sbjct: 676 QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEIC 735
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE---EEEFIQ 1152
KE +L +N + ++ S++ + Q + Q
Sbjct: 736 KE-ELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQ 794
Query: 1153 ERSVLQEQSAKLNTELQECYTKII-QLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
++ +LQ+++ + N EL++ TK+ Q+ L EL + E++ +++ K E E D
Sbjct: 795 QQQMLQQETIR-NGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEAD 853
Query: 1212 NLLSTVAELRSS---ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKY 1268
V EL + + +DQ E++++ K+ + + K H S+
Sbjct: 854 LKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL---------SQL 904
Query: 1269 EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+ +LD ++ +++TN + +E KLQ E + + + + E+L +E++
Sbjct: 905 DMILDQTKTELEKKTNAVKELE-------KLQHSTE------TELTEALQKREVLETELQ 951
Query: 1329 DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
+ +LR Q + E+ I + A+L++
Sbjct: 952 N--------AHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKM------ 997
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT-ITLTQRNDEFENVRQQLVEYEKR 1447
+ D + ++LE+ L+ ++ E+ Q+ + T + +T R E + Q++++ E
Sbjct: 998 -----EIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGE-MEQKIIKLEGT 1051
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
+E +SEL ++ E E++ +++ K E+L K + +++++
Sbjct: 1052 LE------KSEL-----ELKECNKQIESLN--DKLQNAK--EQLREKEFIMLQNEQEISQ 1096
Query: 1508 LNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ-KHVSFASDTKQ 1566
L K +E + EM++ ++ QE I T E +L +R + ++Q H A Q
Sbjct: 1097 LKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQ 1156
Query: 1567 GRDEQLD-NTMNKELLD 1582
Q + ++ EL D
Sbjct: 1157 QVQAQREIERLSSELED 1173
Score = 87.8 bits (208), Expect = 3e-16
Identities = 142/787 (18%), Positives = 345/787 (43%), Gaps = 51/787 (6%)
Query: 220 KMQENFIAMEAEWKDEKQRLL-KDIESKDVRISSLEEANKL--LEAARFEISLEHSKLAQ 276
+++ I +EAE D K + + + + ++ LE+A+ LE+ + + L +
Sbjct: 526 ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK 585
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE---IANMTELTKKIELLEH 333
+LE+ L ++ +E + E+ +E + E I E KKI L +H
Sbjct: 586 QLEEKIVAYSSIAAKNAELEQELMEKN-EKIRSLETNINTEHEKICLAFEKAKKIHLEQH 644
Query: 334 --LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS-QLS 390
+ QI + +LE K + K +S + +I ++ + ++ + ++
Sbjct: 645 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQD---IICKQHHLESLDRLLTESKGEMK 701
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
E + +D K +N++++ + ++ L+ ++ +E V+ K
Sbjct: 702 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 761
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE---LNDEIKDVNVKDLIEKL 505
L+ + ++ SL + + Q+Q+ Q+ N E++D K +EK
Sbjct: 762 EEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK--LEKQ 819
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSN---HKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
S EQ Q E A ++ K H+ LK+ QK I+ E+ + E
Sbjct: 820 VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR-QKVIELTGTARQVKIEMDQYKE 878
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
EL + +++ L+ + N +HL D MI ++ + N + K E++
Sbjct: 879 ELSKMEKEIMHLKRDGENKAMHLSQLD---MILDQTKTELEKKTNAVKELEKLQHSTETE 935
Query: 623 KFDLVQELHILQQKYDEVEDKL-ADISQLQSDQVCSEIKSVHLEEQ---IDALSASKKEL 678
+ +Q+ +L+ + +L + + QLQ + + + LEE+ I L+A +E
Sbjct: 936 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC 995
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ IE+ K++L + L+ ++ + +M + + +M +KI +L
Sbjct: 996 KMEIED---KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEME-QKIIKLEGT 1051
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ E+S+++ + + +I+ + ++N + +L + + + + E+ I+ ++ +++
Sbjct: 1052 L---EKSELELK-ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 1107
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
++ S ++E+++ + + +L L + + + +L E H+ + Q++ + L
Sbjct: 1108 MKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERL 1167
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESE-STKYQTQLRDLESNLKRITHEHQTL 917
E ++++ + H N L E+ + + E+ + Q +++ L + ++ + +
Sbjct: 1168 SSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME 1227
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
++ ++ +I ++Q +S+++ LNE+ EK + +L+E ++ + NL+
Sbjct: 1228 MISHQENHAKWKISADSQ-KSSVQQ---LNEQLEK-------AKLELEEAQDTVSNLHQQ 1276
Query: 978 VEELNKM 984
V++ N++
Sbjct: 1277 VQDRNEV 1283
Score = 85.0 bits (201), Expect = 2e-15
Identities = 225/1137 (19%), Positives = 467/1137 (41%), Gaps = 107/1137 (9%)
Query: 476 NEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL 535
NE E+L + K V K +EK+++ EE + + + NK + + +K
Sbjct: 239 NEALYNAEELSKAFQQYKKKVAEK--LEKVQAEEEILERNLTNCEKENKRLQERCGLYKS 296
Query: 536 KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+L+ +++ + + +++ KE +R+ + S+ +A+L E + ++ + ++ I
Sbjct: 297 ELEILKEKLRQLKEENNNGKEKLRIMAVKN--SEVMAQLTESRQSILKLESELENKDEIL 354
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV 655
D + M E L + R+ A ++++ DL Q+ ++ E+ ISQL +
Sbjct: 355 RDKFSLMNENREL-KVRVAA----QNERLDLCQQE--IESSRVELRSLEKIISQLPLKRE 407
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKL--DKEQLYGTIKDLENDKEDIMNKLQNY 713
KS + Q+ + S + E KL + ++ IK+ E K
Sbjct: 408 LFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQL 467
Query: 714 IQENMDLTDKLEKMSAEKISELLAKIN-HEEQS-KIQTQFGIDAKIQ-ERDLYIENIESE 770
Q + D E + K+ H+ +S K Q Q ++ + + ER + IE
Sbjct: 468 SQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIE-- 525
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
+ ++++ ++E A D + ++ + Q +E + S + E E+ + + L
Sbjct: 526 --ELRTKLIQIE---AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQL 580
Query: 831 MDHDRVVEKQLL---EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
+ ++ +E++++ I +N EL+++ E+ ++L+ +++ + EKA +
Sbjct: 581 LTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIH 640
Query: 888 LAESESTKYQTQLRD--LESNLKRITHEHQTL------IVQKKKEIEDL-----EIEFNT 934
L + + + Q + + LE ++ + +T+ I+ K+ +E L E +
Sbjct: 641 LEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEM 700
Query: 935 QIESAIRDK--KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
+ E+ +D+ K L + + V QL++ L+ K + L++N E NK E +K
Sbjct: 701 KKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELV-LHLNQLEGNK---EKFEKQ 756
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
++K+ + Y Q E+ N L++ E+ + L + Q + + +L
Sbjct: 757 LKKKSEEV--YCLQ--KELKIKNHSLQETSEQNVILQHTLQQQQ-QMLQQETIRNGELED 811
Query: 1053 FTTKLEN----MEEEMQRVSKQLLDS-KQHNEELQILVREQD---DQIKELKET--KLTF 1102
TKLE +E+E+Q+ + + ++ E+ + E D ++ EL T ++
Sbjct: 812 TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKI 871
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA 1162
EM+ K E + I + D N K + E++ + L++
Sbjct: 872 EMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE-LEKLQH 930
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV----A 1218
TEL E K LET G Q+ +L+ L++ + +T+ A
Sbjct: 931 STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 990
Query: 1219 ELRSSISSAVDQRG--FEIAELWKQH---LAQREADFQKTEHELRVQLSAFESKYEQLLD 1273
ELR D++ E+ + K+ L QR A + +R E K +L
Sbjct: 991 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1050
Query: 1274 SVQSSTQE--ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+++ S E E NK Q+ SL +KLQ+ +E LR ++++ + N+ EI + + E E+
Sbjct: 1051 TLEKSELELKECNK-----QIESLNDKLQNAKEQLR--EKEFIMLQNEQEISQLKKEIER 1103
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
E +S + QEQ I +E L +
Sbjct: 1104 TQ-----------------QRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNS 1146
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN-VRQQLVEYEKRIED 1450
+ +A + ++ ++E SE+ E L++ D N + ++L + R
Sbjct: 1147 HTELAEARHQQVQAQREIERLSSEL-----EDMKQLSKEKDAHGNHLAEELGASKVREAH 1201
Query: 1451 LTYEKESELAILRLKMH--ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL 1508
L ++E+ L ++ + A H E + + + K+ + + LN+Q+ +
Sbjct: 1202 LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQ--LNEQLEKA 1259
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTK 1565
LEE + + ++++ I N+ + ++ + +KI H A D K
Sbjct: 1260 KLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEK-AEDIK 1315
Score = 62.1 bits (144), Expect = 2e-08
Identities = 152/768 (19%), Positives = 307/768 (39%), Gaps = 57/768 (7%)
Query: 58 QKCLENAALVSKRIKEHRKATAELLG-----RPFVPGISESLANTLKQKEILMEKIKQYK 112
++ LE A+ SK E K ++LL + S A + ++ LMEK ++ +
Sbjct: 557 EELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIR 616
Query: 113 ELSKRSSTT---IVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIME 169
L +T I + L +++KD + M +++
Sbjct: 617 SLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQ 676
Query: 170 TTILDLQEKINEKDQII-EAKNKATTXXXXXXXXXXXXXXXXXEDT---KQQMTKMQ--- 222
I+ Q + D+++ E+K + E+T +Q + ++
Sbjct: 677 QDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICK 736
Query: 223 ENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-----LLEAARFEISLEHSKLAQE 277
E + + + K++ K ++ K + L++ K L E + + L+H+ Q+
Sbjct: 737 EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQ 796
Query: 278 --LEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLN 335
L+Q L KQ + E++ + + + S E + ++ +K E H
Sbjct: 797 QMLQQETIRNGELEDTQTKLEKQVSK--LEQELQKQRESSAE--KLRKMEEKCESAAHEA 852
Query: 336 CQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS--RKSGRNTASKMKSPWSQLSSET 393
RQ EL + E K I ++ G N A + S + +T
Sbjct: 853 DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL-SQLDMILDQT 911
Query: 394 LNQDTDKKINK-NEIAKLEMVIQS-LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQ 451
+ +KK N E+ KL+ ++ L + L +E + +E L
Sbjct: 912 -KTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 970
Query: 452 LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ 511
LQ + Q +E + T ++ E E KQEL + D +K+ +LK Q
Sbjct: 971 LQ-KAQLSLE-EKYTTIKDLTAELRECKMEIEDKKQELLE--MDQALKERNWELKQRAAQ 1026
Query: 512 ITQLNDEI----DAANKNMIKVKSN---HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+T L+ I + +IK++ +L+LK+ K I++ + + KE +R E +
Sbjct: 1027 VTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFI 1086
Query: 565 H-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV----YKKMIEMENLAETRLKAISLL 619
Q++++L++E Q + + +S + YK+ I++ E RL +
Sbjct: 1087 MLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ--ELRLTREQVQ 1144
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
S +L + H Q E+E +L+ S+L+ + S+ K H + L ASK A
Sbjct: 1145 NSHT-ELAEARHQQVQAQREIE-RLS--SELEDMKQLSKEKDAHGNHLAEELGASKVREA 1200
Query: 680 LVIENLKLDKEQLYGTIKDLENDKE-DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ ++ + ++L ++ L+ ++++ +N+ + + +K S ++++E L K
Sbjct: 1201 HLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADS--QKSSVQQLNEQLEK 1258
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
E + T + ++Q+R+ IE L +S + RL+ I+
Sbjct: 1259 AKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKIS 1306
>AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein.
Length = 3908
Score = 95.1 bits (226), Expect = 2e-18
Identities = 176/932 (18%), Positives = 401/932 (43%), Gaps = 85/932 (9%)
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E +D L+ E ++E+++ E + E+ E ++Q +A I++
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRE-LEEMRVTYGTEGLQQLQE---FEAAIKQ 202
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
RD I + + L + + + ++ L+ + QL + + +S
Sbjct: 203 RDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA- 261
Query: 820 EDELVNRLAVLMDHDRVVEKQ--LLEIEHENKE--------LQKKNQIL-LEENQNLQIS 868
+L+ ++ H + +E+Q LLE + KE LQ+K ++ +E+++ ++ S
Sbjct: 262 --DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENS 319
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ Q ++E+ N T + E E K +L+D + ++ E Q IVQK +EI+++
Sbjct: 320 NKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLE 987
++E + + + + + E + Q + ++ + + +L ++ E
Sbjct: 377 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 436
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQVSYMSM-VS 1044
L + + Q+ + Q++ ++ ++ K + E + N +N Q+ M++ ++
Sbjct: 437 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ KL ++ E ++EE+ + ++ ++ E+L + +QI+ ++T E
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + + ST+E + + L+++ E E + L+ +
Sbjct: 557 KLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKIKLEMLEKEK 607
Query: 1165 NTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN--DNLLSTVA 1218
N L ++ +LE L T+L ++E++++LK LE ++N E DNL
Sbjct: 608 NAVLDRMAESQEAELERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 664
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKYEQL---LDS 1274
+ + + + Q+ E + K +L ++ +L+ +Q S SK E++ ++
Sbjct: 665 QQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 1275 VQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q QEE K ++V LQ K + E+ ++ + + Q+E S ++DE
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Query: 1331 KVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
K +++S + E+ I + EEN LK+
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
+ AE K E+ +Q EL++ EY L ++D ++ +Q +EY+ ++
Sbjct: 844 EKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNKQELEYKSKL 893
Query: 1449 ----EDLTYEKESELAI-LRLKMHENANHY--ETMQKESEIER--VKLIEELNVKITESV 1499
E+L ++ + + ++ + + + ET++ +E+ +L+E+L V E +
Sbjct: 894 KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKL 953
Query: 1500 SLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L++++++L++ L+ EEV K + +L +E+EI+ ++ N+Q+
Sbjct: 954 ELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRELEIIINHNRAENVQSCD 1013
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
SS + V+ S +G +++ + +E
Sbjct: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
Score = 89.4 bits (212), Expect = 9e-17
Identities = 160/818 (19%), Positives = 358/818 (43%), Gaps = 84/818 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQI 512
QLEH + + + ++ E K QE+L++ L++E + + L +L AE I
Sbjct: 1868 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR--AREQLAVELSKAEGVI 1925
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
DE + I+ K++ +L+Q N ++ + E ++ EE LS++
Sbjct: 1926 DGYADE-KTLFERQIQEKTDIIDRLEQELLCASN--RLQELEAEQQQIQEERELLSRQKE 1982
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
++ E G ++ L+ E E L + +L+ E + DL +++
Sbjct: 1983 AMKAEAGPVEQQLLQ----------------ETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2026
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+ +VE++++ +L+ ++ + + L +Q AL +++ ++ +D+E
Sbjct: 2027 LE---IDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH- 2079
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKIQTQF 751
+ D+ + +++ + + + + +S + E+ NH +E++ ++
Sbjct: 2080 ----------ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2129
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ + +RD+ N E+ K + R+ LE+++ V D +E + G+ ++ K +
Sbjct: 2130 LLSKEQLQRDIQERN--EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHFGA-VEAKPE 2185
Query: 812 AYSEYTIQ--EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
E +Q D + + + + + +E+ E+E++N+E+Q+ + L + + L
Sbjct: 2186 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2245
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDL 928
+++Q + + LA ES TQ + L +I E + I Q +++ L
Sbjct: 2246 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2305
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ Q D KV+ EK E + TQ+E + + + N +E+LN++ +E
Sbjct: 2306 Q-----QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV-IEK 2359
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN--NAQVSYM-SMVSD 1045
+ + + ++ E + L L E +AL Q++ N ++++M +++ +
Sbjct: 2360 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2419
Query: 1046 YESKLAQFTTKLENMEEEMQRVSK-QLLDSKQHNEELQILVREQ--------DDQIKELK 1096
K+ Q T +L +++ E + V K Q + N + L +++ +D +K L
Sbjct: 2420 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL- 2478
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
E + F+ +G II+ + + A +++ + Q E E +Q
Sbjct: 2479 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2538
Query: 1153 ER-----SVLQEQSA-----KLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQI--NQL 1199
++ +++E+ A ++ E + Y K Q +T+++E ++ N Q+ ++L
Sbjct: 2539 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2598
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
S + L L S V E+ +S+ +++ EIAE
Sbjct: 2599 GSDISALTLRISELESQVVEMHTSL--ILEKEQVEIAE 2634
Score = 84.6 bits (200), Expect = 3e-15
Identities = 176/943 (18%), Positives = 393/943 (41%), Gaps = 62/943 (6%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 471 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 529
Query: 207 XXXXXED---TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
E+ +++Q+ + ++ E++ +E + L +E I S E+ K LE
Sbjct: 530 LEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELEL- 587
Query: 264 RFEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIA 319
+ E + + K+ E+ E+ L + + + E+ + K LEI
Sbjct: 588 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Query: 320 NMTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRN 377
+ + K K L H QI E+ K+ TM E + + + IS+ K +
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 707
Query: 378 TASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
+ KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 708 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 767
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 768 EKFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEK 820
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 821 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLE 879
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 880 DSKNKQELEYKS-KLKALNEE---LHLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMG 931
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
++E +L+++L + +++ E+ +L+D+S+ Q EI L E++ +L K+
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKPKPGEIS--FLNEEVKSLKPEKE 988
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
++L L++ + +++++ + + L + +T + + S K+++
Sbjct: 989 PVSLRCRELEIIIN--HNRAENVQSCDTQVSSLLDGVV----TMTSRGAEGSVSKVNKSF 1042
Query: 737 ---AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+KI E++ + + + ++ L ++++ S + R + E+ + ++
Sbjct: 1043 GEESKIMVEDKVSFE-NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 1101
Query: 794 SLERKADQLGSYLQEKQKAYS-EYTIQEDELVNRLAVLMDHD--RVVEKQLLEIEHENKE 850
L+ + + L ++ ++ S Y+ D++ + D + E+ + E + KE
Sbjct: 1102 -LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE---------SESTKYQTQLR 901
LQK +Q+ L+ + + D + + L+ K + E S +Y T
Sbjct: 1161 LQKIHQLELQTMKTQE--TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
E N + + + + E++D E E+ + E+Y K + T+L
Sbjct: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL- 1277
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL--LK 1019
+++ + + L E L K E + H Q T D + ++++ L L K
Sbjct: 1278 SKIWGQQTDGMKLEFGEENLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSLQDLEKTK 1335
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
Q +E++ L I++ Q +YE+++ +L+ + E
Sbjct: 1336 QLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1378
Score = 83.4 bits (197), Expect = 6e-15
Identities = 271/1436 (18%), Positives = 577/1436 (40%), Gaps = 143/1436 (9%)
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQ 276
Q + ++ I E E ++ +K E+ V L+E KL++ + E+ + K+
Sbjct: 1961 QELEAEQQQIQEERELLSRQKEAMK-AEAGPVEQQLLQETEKLMKE-KLEVQCQAEKVRD 2018
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNC 336
+L++ + IE E+ TE+ + A +L K + L+
Sbjct: 2019 DLQKQVKALEIDVEEQ---VSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI 2075
Query: 337 QIRQTNKELENKLATMGTESKAVS--SP-SKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+ ++ + + K V P S+ + + + + K LS E
Sbjct: 2076 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2135
Query: 394 LNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQ 453
L +D ++ EI KLE ++ L + L + DT G +L
Sbjct: 2136 LQRDIQER--NEEIEKLEFRVRELEQAL------LVSADTFQKVEDRKHFGAVEAKPELS 2187
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL---NDEIKDVNVKDLIEKLKSAE- 509
LE Q E + + +++ + + EQ ++EL N+E++ ++++ I+K +S
Sbjct: 2188 LEVQLQAERDA---IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2244
Query: 510 -EQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SDSNKEIVRLTEELHH 566
+++ Q N D K + +K + + + F+++ + EI +L E++
Sbjct: 2245 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2304
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
L Q++ + K + + + D +E+ + M + E + R + I L L
Sbjct: 2305 LQQQLKITTDNKVIEEKNELIRD----LETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2360
Query: 627 VQELHILQQKYDEVEDKL---ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
QEL + QK L AD + Q D V +E + LE+Q++ + + V++
Sbjct: 2361 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE--KLALEQQVETANEEMTFMKNVLK 2418
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
QL + L+ ++E + K+Q+ + ++++ ++ +S +K EL + +
Sbjct: 2419 ETNFKMNQLTQELFSLKRERESV-EKIQSIPENSVNVA--IDHLSKDK-PELEVVLTEDA 2474
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC----RLEESIAVMEDRRYSLERKA 799
++ Q + + I N+E+ L + +S + L + ++D + + +
Sbjct: 2475 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 2534
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE-KQLLEIEHENKELQKKNQIL 858
+ L + QK E +L + ++ + + Q + E E +Q NQ+
Sbjct: 2535 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 2594
Query: 859 LEENQN----LQISLSDMQQH----YNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
+E + L + +S+++ + +L+ + + ++AE + + +L +L+ L+
Sbjct: 2595 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG- 2653
Query: 911 THEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
+E + +KK+ +D+E+ + T++ + + NE E V +A+L YK
Sbjct: 2654 -NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT-KAELASYKE 2711
Query: 970 NIENLN--MNVEELNKMNLEL----IDKHVQKQQT-----QSPDYTEQYINE-------- 1010
E L + V+E N +L+ + H+ + + + D TE ++
Sbjct: 2712 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2771
Query: 1011 -INKLNALLKQKDE--EIIALNQK----INNA--QVSYMSMVSDYESK--LAQFTTKLEN 1059
I ++ Q D +I + NQ + NA Q++ S S E ++QFT K+E
Sbjct: 2772 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2831
Query: 1060 MEE---------EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKT 1109
M+E E + +S+ ++H +Q+L +E+ +K + + + E +IP+
Sbjct: 2832 MQELHAAEILDMESRHISETETLKREHYVAVQLL-KEECGTLKAVIQCLRSKEGSSIPEL 2890
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQ 1169
T E S D+ + D + E + S K+ L+
Sbjct: 2891 AHSDAYQTREICSSDSGS-DWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR 2949
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ + +Q+ +L TE D I Q+ E E ++T++ L+ I+
Sbjct: 2950 AVHNEGMQVLSL-TESPYSDG-EDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQL 3004
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLS-AFESKYEQLLDSVQSS-TQEETNKIV 1287
QR E+ + + H F EL + L F + LL + ++ T T V
Sbjct: 3005 QREAEVYDSSQSH-----ESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAV 3059
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQE--KYAD---VINQIEILRSEIEDEKVAFXXXXXXXX 1342
+ + L+ ++Q++ + E + AD ++++I+ L +++ K+
Sbjct: 3060 GL--LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3117
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
+++ + +MQ + + ++ + +L++ + A+ K
Sbjct: 3118 PSQELLEYNIQQKQSQMLEMQVE-LSSMKDRATELQEQLSSEKMVVAELKSEL--AQTK- 3173
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
LEL L+ + + ++ + + + + DE + L +K+ +L + E E A L
Sbjct: 3174 LELETTLKAQHKHL-KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3232
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
E KE +E+L + N Q LN LE++ NE
Sbjct: 3233 --------GRSEERDKEE-------LEDLKFSLESQKQRNLQ---LNLLLEQQKQLLNES 3274
Query: 1523 QTALENQEI--EIVTLNDEITNLQNMVRASSSKIQ-KHVSFASDTKQGRDEQLDNT 1575
Q +E+Q + + ++ NL+ V S K++ + +S D ++ QL ++
Sbjct: 3275 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS 3330
Score = 74.5 bits (175), Expect = 3e-12
Identities = 178/974 (18%), Positives = 401/974 (41%), Gaps = 103/974 (10%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS----ASKKELALVIENLKLD 688
LQ++ + +LA S + ++ + SE + V LEE ++AL A +++L + N
Sbjct: 1627 LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE-LEALKQLSLAGREKLCCELRNSSTQ 1685
Query: 689 KE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
+ + G +++ ++++ K ++ E + E+ + +K + L KI E
Sbjct: 1686 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL----SNERYALQKANNRLLKILLE--- 1738
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
++T ++ I L I + S+ S I R E +V R D
Sbjct: 1739 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD----- 1793
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN-QILLEENQN 864
E +YS + ++ +N + + + + ++L+ E+ +N +++L +
Sbjct: 1794 --ESIPSYSGSDMPRND-INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR 1850
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE 924
LQ ++ + + + + + ++E + + + + + E + + ++ +
Sbjct: 1851 LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1910
Query: 925 IEDLEIEFNTQ---IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEEL 981
E L +E + I+ +K + + ++ + + +LE +L N ++ L +++
Sbjct: 1911 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQI 1970
Query: 982 NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
+ EL+ + + + ++ +Q + E K L+K+K E + ++ Q +
Sbjct: 1971 QE-ERELLSRQKEAMKAEAGPVEQQLLQETEK---LMKEKLEVQCQAEKVRDDLQKQVKA 2026
Query: 1042 MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ----DDQIKELKE 1097
+ D E ++++F +LE Q + +L+D +Q N+ L+ + + D+Q + +
Sbjct: 2027 LEIDVEEQVSRF-IELE------QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2079
Query: 1098 TKLTFEMNIPKTEGMI-ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ F+ I K E + + +P+S+ K + E + +
Sbjct: 2080 ERDVFQQEIQKLEQQLKVVPRFQPISEH----QTREVEQLANHLKEKTDKCSELLLSKEQ 2135
Query: 1157 LQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLE-----QLNTE 1209
LQ + N E+++ ++ +LE L + T V +++ +++K E QL E
Sbjct: 2136 LQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE 2195
Query: 1210 NDNL------LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA 1263
D + ++ + E ++ + E+ +L Q Q++ + + EL +
Sbjct: 2196 RDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENKL 2254
Query: 1264 FESKYEQL-LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
F+ E+L L +S ++ V + + +Q+KE + L E+ + Q++I
Sbjct: 2255 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI---IQEKEVEIDQLNEQVTKLQQQLKI 2311
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSX 1382
D KV L ++ + K+ +E+ I +NE +L++
Sbjct: 2312 ----TTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2365
Query: 1383 XXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
+++ EA L HQL++ +E + L Q
Sbjct: 2366 NIGQKTSMNAHSLSE-EAD--SLKHQLDVVIAE--------KLALEQ------------- 2401
Query: 1443 EYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE-IERVKLIEELNVKITESVSL 1501
+ E E++T+ K + L KM++ ++++E E +E+++ I E +V + L
Sbjct: 2402 QVETANEEMTFMK-NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID-HL 2459
Query: 1502 NKQVAELNKALEEEVAKTNEMQTAL----ENQEIEIVTLNDEITNLQNMVRASSSKI-QK 1556
+K EL L E+ K+ E QT EN + I+ L + L++ V A ++ Q
Sbjct: 2460 SKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQC 2519
Query: 1557 HVSFASDTKQGRDE 1570
+ +QG+ E
Sbjct: 2520 YKQIKDMQEQGQFE 2533
Score = 65.7 bits (153), Expect = 1e-09
Identities = 130/687 (18%), Positives = 274/687 (39%), Gaps = 61/687 (8%)
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + +E I +T I + ++ + + ++E +++ + + + +
Sbjct: 65 MYINSSQRVESTVIPEST-IMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ NL L ++ + S + + + + L K EI LN+++ +
Sbjct: 124 VMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR 182
Query: 1037 VSY----MSMVSDYESKL-------AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
V+Y + + ++E+ + Q T L+ E ++ L+ + +++LQI
Sbjct: 183 VTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242
Query: 1086 RE--QDDQIKELKETKLTFEMNIPKTEGMIISSTIEP----MSDDANNVDXXXXXXXXXX 1139
++ + ++ + ++ K + + +E + D +
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+KV E E+ + + +E+ + T ++E TKII+ E EL + + +L
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
Query: 1200 KSKLEQLNTENDNL---LSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADF-QKT 1253
+ ++ Q N E N+ L+ + S + Q + EL K++ +Q E D Q+
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Query: 1254 EHELRVQLSAFESKYEQLLDS--VQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNL- 1309
E E + +L ++ +++ VQ + + ME++ T + ++++ N+
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482
Query: 1310 ----QEKYADV-INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQM 1362
Q K +V IN++ I + +K L E S+ +
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 1363 Q-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA-KVLELTHQLELKDSEI---- 1416
Q +++ I E+ ++L ++ V+ +E+ K LEL H+ E+ + +I
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602
Query: 1417 --YQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIEDLTYEKESELAILRLKMHENAN-H 1472
+K + E E +R QL+ +E+ + L + E E I K+ +N H
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
Query: 1473 Y---------ETMQK--ESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEEVAKTN 1520
Y E QK + E+ LI + N I E L + Q + +N EE + N
Sbjct: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 722
Query: 1521 EMQTALE---NQEIEIVTLNDEITNLQ 1544
E+Q +E +E E TL E+ LQ
Sbjct: 723 ELQKEIEILRQEEKEKGTLEQEVQELQ 749
Score = 61.7 bits (143), Expect = 2e-08
Identities = 198/1129 (17%), Positives = 454/1129 (40%), Gaps = 85/1129 (7%)
Query: 488 ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF 547
++N + K +++DL EK K EEQ+ +L I + + + + + N++ ++ +QK +
Sbjct: 1318 DVNHKSKLSSLQDL-EKTKQLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAV 1376
Query: 548 SKVSDSNK---EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
S+ + + V +TE + ++ + + + G E+++ K ++E
Sbjct: 1377 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG-EFGVKEETNIVK-LLE 1434
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
+ + + ++ S Q+ + + ++ A S Q+ VC + +
Sbjct: 1435 KQYQEQLEEEVAKVIVSMSIAFAQQTEL--SRISGGKENTA--SSKQAHAVCQQEQHYFN 1490
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNKLQNY-IQENMD--L 720
E ++ + V ++K KE+ K+L E+ KE +++ + I E+ D L
Sbjct: 1491 EMKLSQDQIGFQTFETV--DVKF-KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1547
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
T E S +K + I H+E S + E L E++ EL + +
Sbjct: 1548 TISEEMFSKDKTFIVRQSI-HDEISVSSMDASRQLMLNEEQL--EDMRQELVRQYQEHQQ 1604
Query: 781 LEESIAV-----MEDRRYS---LERKADQLGSYLQEKQKAYSEYTIQEDE--LVNRLAVL 830
E + ME +R L+ + +L L ++ +E + E E L+ L L
Sbjct: 1605 ATELLRQAHMPQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEAL 1664
Query: 831 MDHDRVV-EKQLLEIEHENKELQK--KNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
EK E+ + + + Q +NQ +EE + L + + R
Sbjct: 1665 KQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYA 1724
Query: 888 LAESESTKYQTQLRDLESN--LKRITHEHQTLIVQKK-KEIEDLEIEFNTQIESAIRDKK 944
L ++ + + L +++ ++ H I+ + K + + ++ E+++ K
Sbjct: 1725 LQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV--KS 1782
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
++E++ + + + +N+I + EE +++ L+ + P+
Sbjct: 1783 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID-PENE 1841
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
E +N ++L A +++ E I + ++ +A+V+ ++ + + + T L+ EE
Sbjct: 1842 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1901
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI--ISSTIEPMS 1122
+R+ ++ + E+L + + + + I + K FE I + +I + + S
Sbjct: 1902 ERLHEE----SRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1957
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEE----EEFIQERSVLQEQSAKLNTELQ-ECYTKIIQ 1177
+ ++ L Q+E E E+ +LQE + +L+ +C + ++
Sbjct: 1958 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2017
Query: 1178 LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
+ L ++ ++ +EQ+++ ++ NTE +L L + ++ +
Sbjct: 2018 -DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM--RKFLDEQA 2074
Query: 1238 LWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN 1297
+ ++H +R+ FQ+ +L QL +++ + + ++ N + E+
Sbjct: 2075 IDREH--ERDV-FQQEIQKLEQQLKVVP-RFQPISEHQTREVEQLANHL--KEKTDKCSE 2128
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
L KE+ R++QE+ + I ++E E+E + + + E
Sbjct: 2129 LLLSKEQLQRDIQERNEE-IEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELS 2187
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
Q+Q E +A +K + + E ++ + +LE K+ E+
Sbjct: 2188 LEVQLQA-------ERDAIDRKEK------------EITNLEEQLEQFREELENKNEEVQ 2228
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
Q + I + + + Q+ ++ +E L + A+ H + +
Sbjct: 2229 QLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII 2288
Query: 1478 KESEIERVKLIEELN-----VKITESVSLNKQVAELNKALEEEV-AKTNEMQTALENQEI 1531
+E E+E +L E++ +KIT + ++ EL + LE ++ ++ + N+E
Sbjct: 2289 QEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE 2348
Query: 1532 EIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKEL 1580
EI LN+ I LQ + K + S+ QLD + ++L
Sbjct: 2349 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL 2397
Score = 58.4 bits (135), Expect = 2e-07
Identities = 93/502 (18%), Positives = 206/502 (41%), Gaps = 36/502 (7%)
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
+N ++ L D ++ K L+ E E + + ++ + L ++L + +++ A
Sbjct: 2989 INTISSLKD---LITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3045
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI--VQKK------KEIEDLEIEFNTQ 935
RT+L +T L LE ++ E+Q + +QK EI+ L + N +
Sbjct: 3046 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3105
Query: 936 IESAIRDK---KVLNEKYEKNIEY----VTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ R++ K E E NI+ + +++ +L K+ L + + EL
Sbjct: 3106 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3165
Query: 989 IDKHVQKQQTQSPDYTEQY--INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+ Q + Q+ + E+ +K K +E+ LN + + Q +
Sbjct: 3166 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3225
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
E + A+ E +EE++ + L KQ N +L +L+ +Q + E ++ ++ +
Sbjct: 3226 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3285
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS- 1161
+ + + +G + + S+ + ++Q + Q R L +
Sbjct: 3286 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3345
Query: 1162 -AKLNTELQECYTKIIQL--ET----LNTELTGHDVVNQEQINQLKSKLEQ-LNTENDNL 1213
+L +L+E +++I++L ET L++ T + Q+++ + EQ NTE
Sbjct: 3346 LKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKK 3405
Query: 1214 LSTVAELRSSISSAVDQRGFEI--AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+ + + ++++ ++ +L Q L +FQK E E + + Y+ L
Sbjct: 3406 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3465
Query: 1272 LD-SVQSSTQEETNKIVTMEQV 1292
+ + S T + T V +++
Sbjct: 3466 NEPTTWSLTSDRTRNWVLQQKI 3487
Score = 55.2 bits (127), Expect = 2e-06
Identities = 146/750 (19%), Positives = 326/750 (43%), Gaps = 73/750 (9%)
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKSVHLEEQ 667
E R I+ + S K DL+ ++ + Q+ EV D ++ ++ V LEE+
Sbjct: 2983 EERKAYINTISSLK-DLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEER 3039
Query: 668 IDALSASKKEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
L+A + EL AL + L I++ + + M LQ + L +++
Sbjct: 3040 SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSEIQA 3097
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ A+ + + E++S+ +Q ++ IQ++ + ++ ELS K R L+E ++
Sbjct: 3098 LHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3156
Query: 787 ----VMEDRRYSLERKADQLGSYLQEKQKAYSE---YTIQEDELVNRLAVLMDHDRVVEK 839
V+ + + L + +L + L+ + K E + ++ + + + +L D +K
Sbjct: 3157 SEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK 3216
Query: 840 QLLE----IEHENKELQKKNQILLEENQNLQISLSDMQQ---HYNALVEKANR-----TD 887
+ E +E E +L + + EE ++L+ SL +Q N L+E+ +
Sbjct: 3217 KSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3276
Query: 888 LAESESTKYQTQLRDLES-NLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
ES+ Y QL + + NL+ ++ E + + +++ D E E + Q++S+ D
Sbjct: 3277 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS--DGTG 3334
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+ + + + +L+ QL+E + I L +N E K++ L + ++ Q T
Sbjct: 3335 QSRPPLPSEDLLKELQKQLEEKHSRIVEL-LNETEKYKLD-SLQTRQQMEKDRQVHRKTL 3392
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
Q E N + +++ L K+ + Q + + ++ + + + ++ MQ
Sbjct: 3393 QTEQEAN------TEGQKKMHELQSKVEDLQ----RQLEEKRQQVYKLDLEGQRLQGIMQ 3442
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
KQ L+ ++ E +IL + ++ T+ + +T ++ IE + ++
Sbjct: 3443 EFQKQELEREEKRESRRILYQNLNE--------PTTWSLTSDRTRNWVLQQKIEGETKES 3494
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N E E I+++ LQ ++KL L + ++ +Q ET + E
Sbjct: 3495 NYAKLIEMNGGGTG----CNHELEMIRQK--LQCVASKLQV-LPQKASERLQFETADDE- 3546
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ QE I+++ +L++L + S V+ +S S ++ + AEL H++Q
Sbjct: 3547 --DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTERLLRQNAEL-TGHISQ 3602
Query: 1246 READFQKTEHELRVQLSAFESK---YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+ +++LR + E + Y Q +S++ N +E + + + ++ ++
Sbjct: 3603 ----LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNR 3658
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
E+ LQ+ ++ L++E+ ++ +
Sbjct: 3659 EK--LTLQKSLKRAEAEVYKLKAELRNDSL 3686
Score = 51.2 bits (117), Expect = 3e-05
Identities = 264/1464 (18%), Positives = 593/1464 (40%), Gaps = 150/1464 (10%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-LLEAARFEISLEHSK 273
KQQ+ +Q + EK L+ + IS L++ + L+ + E++L+ ++
Sbjct: 664 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
L +E+E +Q ++ + KTE+ EK E N +L +K LE
Sbjct: 724 LQKEIE-----ILRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKEN--DLQEKFAQLEA 775
Query: 334 LNCQIRQTNKELENKL---ATMGTESKAV--SSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
N ++ K LE+ L + E + + S K + K + + Q
Sbjct: 776 ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 835
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY--VISEKDTXXXXXXXXXXGKD 446
LN++ +K+ N A+ + N + +EY ++ KD
Sbjct: 836 CIQ--LNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVN--------EIAKVQEQLKQELNDEIKDVNV 498
+ + L E P+ + + ++ D + E+ +V E+ EL ++++
Sbjct: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
Query: 499 K--DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK---LKLKQMQKTIDN--FSKVS 551
+ +L ++L EQ+ EI N+ + +K + L+ ++++ I++ V
Sbjct: 951 EKLELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRELEIIINHNRAENVQ 1010
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMI-----EM 605
+ ++ L + + ++ + AE K N +S M+E V ++ M +
Sbjct: 1011 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF---GEESKIMVEDKVSFENMTVGEESKQ 1067
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVC-SEIKSVH 663
E L L +++ S + E LQ++ + ++ + D+ Q+++ ++C S + S H
Sbjct: 1068 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 664 LEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL-- 720
+++ + + K K L + E L +E+ ++ + + M K Q E L
Sbjct: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHL 1186
Query: 721 -TDKLEKMSAEKISELL----AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
KL+K +E+ S L + + ++ + + K D EN + EL Y+
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 776 SRICRLEESIAVMEDR---RYS----LERKADQL-GSYLQEKQKAYSEYTIQEDE----- 822
+ +E++ + ++ Y+ L+ + ++ G + + E + ++E
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
Query: 823 LVNRLAVLMDHDRVVEKQLLEIE--HENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
+ +++ L D D + +L ++ + K+L+++ Q L +LQ L + +Q+Y A +
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKQLEEQVQELESLISSLQQQLKETEQNYEAEI 1366
Query: 881 EKANRTDLAESESTKYQTQLRD----LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ- 935
+ A SEST + D ES+ +R + + KK I D IEF+ +
Sbjct: 1367 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCV----KKNI-DGTIEFSGEF 1421
Query: 936 -IESAIRDKKVLNEKYEKNIE-------------YVTQLE-AQLQEYKNNIENLN----M 976
++ K+L ++Y++ +E + Q E +++ K N + +
Sbjct: 1422 GVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAV 1481
Query: 977 NVEELNKMN-LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
+E + N ++L + Q ++ D ++ E L+ L + +EI+ N ++
Sbjct: 1482 CQQEQHYFNEMKLSQDQIGFQTFETVDV--KFKEEFKPLSKELGEHGKEILLSNSDPHDI 1539
Query: 1036 QVSYMSMVSDYESKLAQFTTKL--ENMEEEM----QRVSKQLLDSKQHNEEL-QILVREQ 1088
S +++ E ++ T + +++ +E+ S+QL+ +++ E++ Q LVR+
Sbjct: 1540 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQY 1599
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE 1148
+ + T+L + ++P+ E E + ++ ++ V E E
Sbjct: 1600 QE---HQQATELLRQAHMPQMERQ--REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1654
Query: 1149 EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+ E +Q + E C + +T N G++ NQ ++ + K ++L+
Sbjct: 1655 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQN----GNE--NQGEVEEQTFKEKELDR 1708
Query: 1209 ENDNLLSTV-AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT----EHELRVQLSA 1263
+ +++ + + R ++ A ++ + E+ K A E + + + Q SA
Sbjct: 1709 KPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSA 1768
Query: 1264 FESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI--E 1321
+ SV+S EE + VT E + S D + N+ K + ++
Sbjct: 1769 SLIWRSEAEASVKSCVHEEHTR-VTDESIPSYSG--SDMPRNDINMWSKVTEEGTELSQR 1825
Query: 1322 ILRS-----EIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
++RS EI+ E + +E S + + + + E+ +
Sbjct: 1826 LVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFR 1885
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI---TLTQRNDE 1433
K+ + R+++ +L +L + I E T+ + ++ D
Sbjct: 1886 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1945
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
+ + Q+L+ R+++L E+E ++ + + E M+ E+ +L++E
Sbjct: 1946 IDRLEQELLCASNRLQEL----EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2001
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL----NDEITNLQNMVRA 1549
+ E + + Q ++ L+++V ++ +E Q + L N E+ +L+ +A
Sbjct: 2002 LMKEKLEVQCQAEKVRDDLQKQV---KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA 2058
Query: 1550 SSSKIQKHVSFASDTKQGRDEQLD 1573
+++K F + R+ + D
Sbjct: 2059 LEKQLEKMRKFLDEQAIDREHERD 2082
Score = 35.1 bits (77), Expect = 2.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 13/153 (8%)
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYE-TMQKESEIERVKL-IEELN 1492
+ +++Q VEY+ +E L L +H N + T+++E E E+ + E N
Sbjct: 3067 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 3126
Query: 1493 VKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVR 1548
++ +S L QV EL+ + + E+Q L ++++ + L E+ L+ ++
Sbjct: 3127 IQQKQSQMLEMQV-ELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3181
Query: 1549 ASSSKIQKHVSFASDTKQGRDE--QLDNTMNKE 1579
A +++ +F + K DE L++T+ E
Sbjct: 3182 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3214
>AF223939-1|AAK00630.1| 2073|Homo sapiens ninein isotype 3 protein.
Length = 2073
Score = 94.7 bits (225), Expect = 2e-18
Identities = 133/631 (21%), Positives = 280/631 (44%), Gaps = 50/631 (7%)
Query: 492 EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS-KV 550
E++ +++L KLK E++T L + D + + + K + +Q T KV
Sbjct: 1438 ELEKTKLQELTRKLK---ERVTILVKQKDVLSHG--EKEEELKAMMHDLQITCSEMQQKV 1492
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKG--NLQLHLVDYDSGRMIESD--VYKKMIEME 606
E +L +E L ++ L EE NL+L + ++SGRM + V ++ ++
Sbjct: 1493 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLYWNSGRMRQKTETVKQENAAVQ 1552
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E K IS L+ + L E L QK + ++KL +++Q ++ +C + K E
Sbjct: 1553 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK----EP 1608
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI--QENMDLTDKL 724
AL ++E + E L+ K Q + LE + ++ K+Q +I QEN L D+L
Sbjct: 1609 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDEL 1666
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEE 783
EKM L+ Q KI + + K+ +E++ E + S + K ++ LE
Sbjct: 1667 EKMKQLHRCPDLSDF----QQKISSVLSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEH 1721
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQL 841
IA M+ + S E ++ L S L Q+ E T+Q L +++ + RV +++
Sbjct: 1722 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL--QMSRMKSDLRVTQQEK 1779
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
++ E L K+ Q ++ +I+ H +K D + + Q L
Sbjct: 1780 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQ---QKRLSWDKLDHLMNEEQQLLW 1836
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN-------------E 948
+ + EHQ+ + ++++ LE + + + +N +
Sbjct: 1837 QENERSQTMVQEHQSRLTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECD 1896
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-----HVQKQQTQSPDY 1003
+++K + +Q+ + +E +++ E L K ++L ++ H++ T SP
Sbjct: 1897 QFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS- 1955
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ ++ + A E+ + L +++ A+ + + E++ ++ T N E+
Sbjct: 1956 PHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQL 2015
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ + +++++ +Q + ++ L++E+ +Q+KE
Sbjct: 2016 VTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2046
Score = 91.5 bits (217), Expect = 2e-17
Identities = 233/1152 (20%), Positives = 477/1152 (41%), Gaps = 115/1152 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E E A+ QE LK+ L E K ++ E+ + LN + + + ++
Sbjct: 847 ELTQECAEAQELLKETLKRE-KTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL 905
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
+ Q D ++ S+K +R EE+ L Q A + L+ +++D R
Sbjct: 906 RNVSETQQSMLSDQILELKSSHKRELREREEV--LCQAGASEQLASQRLERLEMEHDQER 963
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
++ K++ MEN+ + + + ++ ++ E+ LQ K E++ + +S LQ+
Sbjct: 964 Q---EMMSKLLAMENIHKATCETA---DRERAEMSTEISRLQSKIKEMQQATSPLSMLQN 1017
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIEN----LKLDK--EQLYGTIKDLENDKEDI 706
C I +E ALS ++ L+ EN L L + EQ + + +
Sbjct: 1018 G--CQVIGEEEVEGD-GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRL 1074
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLYIE 765
+LQ ++ + ++ L++ + E + +Q++ + G+ + DL +
Sbjct: 1075 QQRLQK-LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1133
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ S S + R E I E+ S+E ++ S +E + E Q +L
Sbjct: 1134 EVRDLGSTGTSSVQRQEAKI---EESEASVEGFSELENS--EETRTESWELKNQISQLQE 1188
Query: 826 RLAVLM-DHDRVVEKQ---LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+L +L D DR EK+ L ++ K+L+ +I E + ++ D+ + + L E
Sbjct: 1189 QLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP-EASPKYKLLYEDVSRENDCLQE 1247
Query: 882 KAN----RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D A + + ++ L+ LK++ +T + +K ++++IE N ++
Sbjct: 1248 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSYDEVKIE-NEELN 1305
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM----NVEELNKMNLELIDK-- 991
+ L K EK E V Q ++ ++ENL + N+ +LN+ E + +
Sbjct: 1306 VLVLR---LQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1361
Query: 992 ---HVQKQQTQSPDYTE---QYI-----NEINKLNALLKQKDEEIIALNQKI---NNAQV 1037
HV ++ Q Y E Q + +EI L+ ++ E NQ I N +
Sbjct: 1362 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLL 1421
Query: 1038 SYMSMVSDYESKLAQFT---TKLENMEEEM-QRVS-----KQLLDSKQHNEELQILVREQ 1088
+ +++ +A+ TKL+ + ++ +RV+ K +L + EEL+ ++ +
Sbjct: 1422 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1481
Query: 1089 DDQIKELKETK--LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
E+++ L +E + E I+ + I ++++ + + ++ Q+
Sbjct: 1482 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLYWNSGRMR-QK 1540
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL------- 1199
E QE + +Q+ L ++ E K QL+ NTEL+ + NQE++ +L
Sbjct: 1541 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1600
Query: 1200 ---------KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREAD 1249
S LE+ E NL + + S+ V E++E+ Q H+ Q+E
Sbjct: 1601 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1660
Query: 1250 FQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK---E 1303
K E E QL S ++Q + SV S ++ K E++ S +KL E
Sbjct: 1661 LLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1720
Query: 1304 EHLRNLQEKYADVINQIEILRSEI--EDEKVA-FXXXXXXXXXXXXXXXXDLRTENQSYK 1360
+ ++++ +Q L+S++ EKV DLR Q K
Sbjct: 1721 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-K 1779
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKT 1420
+ +Q +++++++ S +L H + + ++Q+
Sbjct: 1780 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE- 1838
Query: 1421 HEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
+E + T+ Q + + +L +++ L ES L L H+ + +
Sbjct: 1839 NERSQTMVQEH------QSRLTHSREKVRQL----ESNL----LPKHQKHLNPSGTMNPT 1884
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
E E++ L E + E N++V+++N +LE+E+ + L+ +++++ E+
Sbjct: 1885 EQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEM 1943
Query: 1541 TNLQNMVRASSS 1552
+L++ S S
Sbjct: 1944 QHLRSTATPSPS 1955
Score = 66.9 bits (156), Expect = 6e-10
Identities = 216/1015 (21%), Positives = 397/1015 (39%), Gaps = 110/1015 (10%)
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLE 700
+++ D Q + + EI L+ +D ++ ++ LAL E L + +
Sbjct: 308 ERILDTWQEEGIENSQEILKA-LDFSLDGNINLTELTLALEYELLVTKNSTHQAALASFK 366
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ ++ ++ ++E L L+K AEK+ L+A S++ A I+ R
Sbjct: 367 AEIRHLLERVDQVVREKEKLRSDLDK--AEKLKSLMA-------SEVDDHH---AAIERR 414
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQE 820
+ Y N+ +YK RI L+ + ++R L++ Q QE +KA +E E
Sbjct: 415 NEY--NLRKLDEEYKERIAALKNELR--KEREQILQQAGKQRLELEQEIEKAKTE----E 466
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSDMQQHYNA 878
+ + +RLA+ + + +E +LLE EN +K + + + L+ M+ Y
Sbjct: 467 NYIRDRLALSLKENSRLENELLE-NAENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 525
Query: 879 LVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ D +SE +Y+ Q R L LK E + L E +
Sbjct: 526 QCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 585
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQ 996
+I + V+ + E++ + L +L++ + E L+ V K + +H +
Sbjct: 586 MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 645
Query: 997 QTQSPDYTE--QYINEINKLNALLKQ--------KDEEIIALNQKINNAQVSYMSMV--- 1043
T ++ I E+ A+LK+ +EE L K+ + +
Sbjct: 646 HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 705
Query: 1044 --SDYESKLAQFTTKLENMEEEMQ-------RVSKQLLDSKQ-HNEELQILVR----EQD 1089
+ +++L Q E E +Q +V + +Q H E+L LV E++
Sbjct: 706 HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 765
Query: 1090 DQIKELKE---TKLTFEMNIPKTEGMIISSTIE-PMSDDANNVDXXXXXXXXXXXXLKVQ 1145
+ KEL E +L +TE +S IE D V Q
Sbjct: 766 ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 825
Query: 1146 EEEEFIQERSVLQEQSAKLNTEL-QEC-YTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
E ++ +++ + Q EL QEC + + ETL E T V+ QE+ K+
Sbjct: 826 ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 885
Query: 1204 EQLNT---ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
E LN+ E LL + +LR+ + +I EL H +RE + E+ Q
Sbjct: 886 EHLNSMVVERQQLLQDLEDLRNVSETQQSMLSDQILELKSSH--KREL---REREEVLCQ 940
Query: 1261 LSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
A E Q L+ ++ QE +K++ ME + + D+E A++
Sbjct: 941 AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER---------AEM 991
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN-----QSYKQMQEQS---IL 1368
+I L+S+I++ + A ++ + Q +Q+ E++ +L
Sbjct: 992 STEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1051
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
++ + Q K + R+ E L ++ L+ +E + T E T
Sbjct: 1052 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPG-LVMSSCLDEPATEFFGNTAEQTEPFL 1110
Query: 1429 QRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE--IERVK 1486
Q+N R + VE R L+ ++ E+ L + E +ESE +E
Sbjct: 1111 QQN------RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEAKIEESEASVEGFS 1164
Query: 1487 LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
+E TES L Q+++L + L A + ++ ++ L ++ L+ +
Sbjct: 1165 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1224
Query: 1547 VRASS--SKIQKHVSFASDTKQGR--------DEQLDNTMNKELLDAVPRAELDL 1591
AS + + VS +D Q DE L+N NKEL V R + +L
Sbjct: 1225 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALEN--NKELTAEVFRLQDEL 1277
Score = 62.1 bits (144), Expect = 2e-08
Identities = 172/849 (20%), Positives = 336/849 (39%), Gaps = 65/849 (7%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAA---NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+D+ + +E++ + D A NK + + +LK+M++ + F + S
Sbjct: 1236 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD 1295
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ EEL+ L V L+ + LQ +V + E+ + IE + L+
Sbjct: 1296 EVKIENEELNVL---VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG---NILQL 1349
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE + V+ +H + ++ + L +QL EI +H Q
Sbjct: 1350 NQTLE-ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV 1408
Query: 676 KELALVIENLKL----DKE-QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
+ ++ EN L DK Q TI +LE +K + + + L + + +S
Sbjct: 1409 QNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1468
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
+ E L + H+ Q T + K++ E ++ E S ++ I L E ++
Sbjct: 1469 EKEEELKAMMHDLQI---TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1525
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ +L + ++ ++K + + ++V L + ++ +QL + EN E
Sbjct: 1526 KLGTLYWNSGRM----RQKTETVKQENAAVQKMVENLKKQISELKIKNQQL---DLENTE 1578
Query: 851 LQKKNQILLEENQNLQISLSDM------QQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
L +KN E+ Q L L++M + +AL E+ + E + + Q L
Sbjct: 1579 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLV 1638
Query: 905 SNLKRITHEH--QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
S+L+ E QT IVQ++ + E+E Q+ D +K + Y +L
Sbjct: 1639 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRC-PDLSDFQQKISSVLSYNEKL-- 1695
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
L+E + E LN V++L K +L ++ + + + + Q + L + L
Sbjct: 1696 -LKEKEALSEELNSCVDKLAKSSL--LEHRIATMKQEQKSWEHQSAS----LKSQLVASQ 1748
Query: 1023 EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS--KQHNEE 1080
E++ L + N + M SD ++ Q + E +++E+ + KQL ++ K E
Sbjct: 1749 EKVQNLEDTVQNVNLQMSRMKSDL--RVTQ--QEKEALKQEVMSLHKQLQNAGGKSWAPE 1804
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+ +Q K L KL MN E ++ E V
Sbjct: 1805 IATHPSGLHNQQKRLSWDKLDHLMN---EEQQLLWQENERSQ---TMVQEHQSRLTHSRE 1858
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
++ Q E + + S +N QE + + + E + + Q+N L+
Sbjct: 1859 KVR-QLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANR-KVSQMNSLE 1916
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI----AELWKQHLAQREA-DFQKTEH 1255
+LE ++ EN+ L +L + R W L Q++A E
Sbjct: 1917 QELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQ 1976
Query: 1256 --ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEK 1312
+L+ QL E + L + +++ T E EQ VT ++ ++ + E+ L+ ++
Sbjct: 1977 FLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRL 2036
Query: 1313 YADVINQIE 1321
+ +NQ++
Sbjct: 2037 LQEKVNQLK 2045
>AF223938-1|AAK00629.1| 2069|Homo sapiens ninein isotype 2 protein.
Length = 2069
Score = 93.9 bits (223), Expect = 4e-18
Identities = 234/1152 (20%), Positives = 477/1152 (41%), Gaps = 115/1152 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E E A+ QE LK+ L E K ++ E+ + LN + + + ++
Sbjct: 847 ELTQECAEAQELLKETLKRE-KTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL 905
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
+ Q D ++ S+K +R EE+ L Q A + L+ +++D R
Sbjct: 906 RNVSETQQSMLSDQILELKSSHKRELREREEV--LCQAGASEQLASQRLERLEMEHDQER 963
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
++ K++ MEN+ + + + ++ ++ E+ LQ K E++ + +S LQ+
Sbjct: 964 Q---EMMSKLLAMENIHKATCETA---DRERAEMSTEISRLQSKIKEMQQATSPLSMLQN 1017
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIEN----LKLDK--EQLYGTIKDLENDKEDI 706
C I +E ALS ++ L+ EN L L + EQ + + +
Sbjct: 1018 G--CQVIGEEEVEGD-GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRL 1074
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLYIE 765
+LQ ++ + ++ L++ + E + +Q++ + G+ + DL +
Sbjct: 1075 QQRLQK-LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1133
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ S S + R E I E+ S+E ++ S +E + E Q +L
Sbjct: 1134 EVRDLGSTGTSSVQRQEAKI---EESEASVEGFSELENS--EETRTESWELKNQISQLQE 1188
Query: 826 RLAVLM-DHDRVVEKQ---LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+L +L D DR EK+ L ++ K+L+ +I E + ++ D+ + + L E
Sbjct: 1189 QLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP-EASPKYKLLYEDVSRENDCLQE 1247
Query: 882 KAN----RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D A + + ++ L+ LK++ +T + +K ++++IE N ++
Sbjct: 1248 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSYDEVKIE-NEELN 1305
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM----NVEELNKMNLELIDK-- 991
+ L K EK E V Q ++ ++ENL + N+ +LN+ E + +
Sbjct: 1306 VLVLR---LQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1361
Query: 992 ---HVQKQQTQSPDYTE---QYI-----NEINKLNALLKQKDEEIIALNQKI---NNAQV 1037
HV ++ Q Y E Q + +EI L+ ++ E NQ I N +
Sbjct: 1362 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLL 1421
Query: 1038 SYMSMVSDYESKLAQFT---TKLENMEEEM-QRVS-----KQLLDSKQHNEELQILVREQ 1088
+ +++ +A+ TKL+ + ++ +RV+ K +L + EEL+ ++ +
Sbjct: 1422 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1481
Query: 1089 DDQIKELKETK--LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
E+++ L +E + E I+ + I ++++ + + ++ Q+
Sbjct: 1482 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLYWNSGRMR-QK 1540
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL------- 1199
E QE + +Q+ L ++ E K QL+ NTEL+ + NQE++ +L
Sbjct: 1541 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1600
Query: 1200 ---------KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREAD 1249
S LE+ E NL + + S+ V E++E+ Q H+ Q+E
Sbjct: 1601 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1660
Query: 1250 FQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK---E 1303
K E E QL S ++Q + SV S ++ K E++ S +KL E
Sbjct: 1661 LLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1720
Query: 1304 EHLRNLQEKYADVINQIEILRSEI--EDEKVA-FXXXXXXXXXXXXXXXXDLRTENQSYK 1360
+ ++++ +Q L+S++ EKV DLR Q K
Sbjct: 1721 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-K 1779
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKT 1420
+ +Q +++++++ S +L H + + ++Q+
Sbjct: 1780 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE- 1838
Query: 1421 HEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
+E + T+ Q N + +L +++ L ES L L H+ + +
Sbjct: 1839 NERSQTMVQ------NTKAELTHSREKVRQL----ESNL----LPKHQKHLNPSGTMNPT 1884
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
E E++ L E + E N++V+++N +LE+E+ + L+ +++++ E+
Sbjct: 1885 EQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEM 1943
Query: 1541 TNLQNMVRASSS 1552
+L++ S S
Sbjct: 1944 QHLRSTATPSPS 1955
Score = 91.5 bits (217), Expect = 2e-17
Identities = 138/637 (21%), Positives = 291/637 (45%), Gaps = 50/637 (7%)
Query: 492 EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS-KV 550
E++ +++L KLK E++T L + D + + + K + +Q T KV
Sbjct: 1438 ELEKTKLQELTRKLK---ERVTILVKQKDVLSHG--EKEEELKAMMHDLQITCSEMQQKV 1492
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKG--NLQLHLVDYDSGRMIESD--VYKKMIEME 606
E +L +E L ++ L EE NL+L + ++SGRM + V ++ ++
Sbjct: 1493 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLYWNSGRMRQKTETVKQENAAVQ 1552
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E K IS L+ + L E L QK + ++KL +++Q ++ +C + K E
Sbjct: 1553 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK----EP 1608
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI--QENMDLTDKL 724
AL ++E + E L+ K Q + LE + ++ K+Q +I QEN L D+L
Sbjct: 1609 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDEL 1666
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEE 783
EKM L+ Q KI + + K+ +E++ E + S + K ++ LE
Sbjct: 1667 EKMKQLHRCPDLSDF----QQKISSVLSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEH 1721
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQL 841
IA M+ + S E ++ L S L Q+ E T+Q L +++ + RV +++
Sbjct: 1722 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL--QMSRMKSDLRVTQQEK 1779
Query: 842 LEIEHENKELQKKNQILLEENQNLQIS-----LSDMQQH--YNALVEKANRTD-LAESES 893
++ E L K+ Q ++ +I+ L + Q+ ++ L N L E+
Sbjct: 1780 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1839
Query: 894 TKYQTQLRDLESNL----KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ QT +++ ++ L +++ L+ + +K + T+ E ++ ++
Sbjct: 1840 ERSQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC--DQ 1897
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-----HVQKQQTQSPDYT 1004
++K + +Q+ + +E +++ E L K ++L ++ H++ T SP
Sbjct: 1898 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS-P 1956
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+ ++ + A E+ + L +++ A+ + + E++ ++ T N E+ +
Sbjct: 1957 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLV 2016
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKE--LKETK 1099
+ +++++ +Q + ++ L++E+ +Q+KE K TK
Sbjct: 2017 TVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTK 2053
Score = 66.9 bits (156), Expect = 6e-10
Identities = 216/1015 (21%), Positives = 397/1015 (39%), Gaps = 110/1015 (10%)
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLE 700
+++ D Q + + EI L+ +D ++ ++ LAL E L + +
Sbjct: 308 ERILDTWQEEGIENSQEILKA-LDFSLDGNINLTELTLALEYELLVTKNSTHQAALASFK 366
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ ++ ++ ++E L L+K AEK+ L+A S++ A I+ R
Sbjct: 367 AEIRHLLERVDQVVREKEKLRSDLDK--AEKLKSLMA-------SEVDDHH---AAIERR 414
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQE 820
+ Y N+ +YK RI L+ + ++R L++ Q QE +KA +E E
Sbjct: 415 NEY--NLRKLDEEYKERIAALKNELR--KEREQILQQAGKQRLELEQEIEKAKTE----E 466
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSDMQQHYNA 878
+ + +RLA+ + + +E +LLE EN +K + + + L+ M+ Y
Sbjct: 467 NYIRDRLALSLKENSRLENELLE-NAENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 525
Query: 879 LVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ D +SE +Y+ Q R L LK E + L E +
Sbjct: 526 QCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 585
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQ 996
+I + V+ + E++ + L +L++ + E L+ V K + +H +
Sbjct: 586 MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 645
Query: 997 QTQSPDYTE--QYINEINKLNALLKQ--------KDEEIIALNQKINNAQVSYMSMV--- 1043
T ++ I E+ A+LK+ +EE L K+ + +
Sbjct: 646 HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 705
Query: 1044 --SDYESKLAQFTTKLENMEEEMQ-------RVSKQLLDSKQ-HNEELQILVR----EQD 1089
+ +++L Q E E +Q +V + +Q H E+L LV E++
Sbjct: 706 HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 765
Query: 1090 DQIKELKE---TKLTFEMNIPKTEGMIISSTIE-PMSDDANNVDXXXXXXXXXXXXLKVQ 1145
+ KEL E +L +TE +S IE D V Q
Sbjct: 766 ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 825
Query: 1146 EEEEFIQERSVLQEQSAKLNTEL-QEC-YTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
E ++ +++ + Q EL QEC + + ETL E T V+ QE+ K+
Sbjct: 826 ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 885
Query: 1204 EQLNT---ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
E LN+ E LL + +LR+ + +I EL H +RE + E+ Q
Sbjct: 886 EHLNSMVVERQQLLQDLEDLRNVSETQQSMLSDQILELKSSH--KREL---REREEVLCQ 940
Query: 1261 LSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
A E Q L+ ++ QE +K++ ME + + D+E A++
Sbjct: 941 AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER---------AEM 991
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN-----QSYKQMQEQS---IL 1368
+I L+S+I++ + A ++ + Q +Q+ E++ +L
Sbjct: 992 STEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1051
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
++ + Q K + R+ E L ++ L+ +E + T E T
Sbjct: 1052 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPG-LVMSSCLDEPATEFFGNTAEQTEPFL 1110
Query: 1429 QRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE--IERVK 1486
Q+N R + VE R L+ ++ E+ L + E +ESE +E
Sbjct: 1111 QQN------RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEAKIEESEASVEGFS 1164
Query: 1487 LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
+E TES L Q+++L + L A + ++ ++ L ++ L+ +
Sbjct: 1165 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1224
Query: 1547 VRASS--SKIQKHVSFASDTKQGR--------DEQLDNTMNKELLDAVPRAELDL 1591
AS + + VS +D Q DE L+N NKEL V R + +L
Sbjct: 1225 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALEN--NKELTAEVFRLQDEL 1277
Score = 64.9 bits (151), Expect = 2e-09
Identities = 172/849 (20%), Positives = 334/849 (39%), Gaps = 65/849 (7%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAA---NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+D+ + +E++ + D A NK + + +LK+M++ + F + S
Sbjct: 1236 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD 1295
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ EEL+ L V L+ + LQ +V + E+ + IE + L+
Sbjct: 1296 EVKIENEELNVL---VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG---NILQL 1349
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE + V+ +H + ++ + L +QL EI +H Q
Sbjct: 1350 NQTLE-ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV 1408
Query: 676 KELALVIENLKL----DKE-QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
+ ++ EN L DK Q TI +LE +K + + + L + + +S
Sbjct: 1409 QNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1468
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
+ E L + H+ Q T + K++ E ++ E S ++ I L E ++
Sbjct: 1469 EKEEELKAMMHDLQI---TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1525
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ +L + ++ ++K + + ++V L + ++ +QL + EN E
Sbjct: 1526 KLGTLYWNSGRM----RQKTETVKQENAAVQKMVENLKKQISELKIKNQQL---DLENTE 1578
Query: 851 LQKKNQILLEENQNLQISLSDM------QQHYNALVEKANRTDLAESESTKYQTQLRDLE 904
L +KN E+ Q L L++M + +AL E+ + E + + Q L
Sbjct: 1579 LSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLV 1638
Query: 905 SNLKRITHEH--QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
S+L+ E QT IVQ++ + E+E Q+ D +K + Y +L
Sbjct: 1639 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRC-PDLSDFQQKISSVLSYNEKL-- 1695
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
L+E + E LN V++L K +L ++ + + + + Q + L + L
Sbjct: 1696 -LKEKEALSEELNSCVDKLAKSSL--LEHRIATMKQEQKSWEHQSAS----LKSQLVASQ 1748
Query: 1023 EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS--KQHNEE 1080
E++ L + N + M SD ++ Q + E +++E+ + KQL ++ K E
Sbjct: 1749 EKVQNLEDTVQNVNLQMSRMKSDL--RVTQ--QEKEALKQEVMSLHKQLQNAGGKSWAPE 1804
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+ +Q K L KL MN E ++ E N
Sbjct: 1805 IATHPSGLHNQQKRLSWDKLDHLMN---EEQQLLWQENERSQTMVQNTKAELTHSREKVR 1861
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
L E + + S +N QE + + + E + + Q+N L+
Sbjct: 1862 QL----ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANR-KVSQMNSLE 1916
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI----AELWKQHLAQREA-DFQKTEH 1255
+LE ++ EN+ L +L + R W L Q++A E
Sbjct: 1917 QELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQ 1976
Query: 1256 --ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEK 1312
+L+ QL E + L + +++ T E EQ VT ++ ++ + E+ L+ ++
Sbjct: 1977 FLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRL 2036
Query: 1313 YADVINQIE 1321
+ +NQ++
Sbjct: 2037 LQEKVNQLK 2045
>AF223937-1|AAK00628.1| 2029|Homo sapiens ninein isotype 1 protein.
Length = 2029
Score = 93.9 bits (223), Expect = 4e-18
Identities = 234/1152 (20%), Positives = 477/1152 (41%), Gaps = 115/1152 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E E A+ QE LK+ L E K ++ E+ + LN + + + ++
Sbjct: 847 ELTQECAEAQELLKETLKRE-KTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL 905
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
+ Q D ++ S+K +R EE+ L Q A + L+ +++D R
Sbjct: 906 RNVSETQQSMLSDQILELKSSHKRELREREEV--LCQAGASEQLASQRLERLEMEHDQER 963
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
++ K++ MEN+ + + + ++ ++ E+ LQ K E++ + +S LQ+
Sbjct: 964 Q---EMMSKLLAMENIHKATCETA---DRERAEMSTEISRLQSKIKEMQQATSPLSMLQN 1017
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIEN----LKLDK--EQLYGTIKDLENDKEDI 706
C I +E ALS ++ L+ EN L L + EQ + + +
Sbjct: 1018 G--CQVIGEEEVEGD-GALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRL 1074
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLYIE 765
+LQ ++ + ++ L++ + E + +Q++ + G+ + DL +
Sbjct: 1075 QQRLQK-LEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1133
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ S S + R E I E+ S+E ++ S +E + E Q +L
Sbjct: 1134 EVRDLGSTGTSSVQRQEAKI---EESEASVEGFSELENS--EETRTESWELKNQISQLQE 1188
Query: 826 RLAVLM-DHDRVVEKQ---LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
+L +L D DR EK+ L ++ K+L+ +I E + ++ D+ + + L E
Sbjct: 1189 QLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIP-EASPKYKLLYEDVSRENDCLQE 1247
Query: 882 KAN----RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D A + + ++ L+ LK++ +T + +K ++++IE N ++
Sbjct: 1248 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSYDEVKIE-NEELN 1305
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM----NVEELNKMNLELIDK-- 991
+ L K EK E V Q ++ ++ENL + N+ +LN+ E + +
Sbjct: 1306 VLVLR---LQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1361
Query: 992 ---HVQKQQTQSPDYTE---QYI-----NEINKLNALLKQKDEEIIALNQKI---NNAQV 1037
HV ++ Q Y E Q + +EI L+ ++ E NQ I N +
Sbjct: 1362 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLL 1421
Query: 1038 SYMSMVSDYESKLAQFT---TKLENMEEEM-QRVS-----KQLLDSKQHNEELQILVREQ 1088
+ +++ +A+ TKL+ + ++ +RV+ K +L + EEL+ ++ +
Sbjct: 1422 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1481
Query: 1089 DDQIKELKETK--LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
E+++ L +E + E I+ + I ++++ + + ++ Q+
Sbjct: 1482 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLYWNSGRMR-QK 1540
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL------- 1199
E QE + +Q+ L ++ E K QL+ NTEL+ + NQE++ +L
Sbjct: 1541 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1600
Query: 1200 ---------KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREAD 1249
S LE+ E NL + + S+ V E++E+ Q H+ Q+E
Sbjct: 1601 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1660
Query: 1250 FQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK---E 1303
K E E QL S ++Q + SV S ++ K E++ S +KL E
Sbjct: 1661 LLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1720
Query: 1304 EHLRNLQEKYADVINQIEILRSEI--EDEKVA-FXXXXXXXXXXXXXXXXDLRTENQSYK 1360
+ ++++ +Q L+S++ EKV DLR Q K
Sbjct: 1721 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-K 1779
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKT 1420
+ +Q +++++++ S +L H + + ++Q+
Sbjct: 1780 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE- 1838
Query: 1421 HEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
+E + T+ Q N + +L +++ L ES L L H+ + +
Sbjct: 1839 NERSQTMVQ------NTKAELTHSREKVRQL----ESNL----LPKHQKHLNPSGTMNPT 1884
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
E E++ L E + E N++V+++N +LE+E+ + L+ +++++ E+
Sbjct: 1885 EQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEM 1943
Query: 1541 TNLQNMVRASSS 1552
+L++ S S
Sbjct: 1944 QHLRSTATPSPS 1955
Score = 66.9 bits (156), Expect = 6e-10
Identities = 216/1015 (21%), Positives = 397/1015 (39%), Gaps = 110/1015 (10%)
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDA-LSASKKELALVIENLKLDKEQLYGTIKDLE 700
+++ D Q + + EI L+ +D ++ ++ LAL E L + +
Sbjct: 308 ERILDTWQEEGIENSQEILKA-LDFSLDGNINLTELTLALEYELLVTKNSTHQAALASFK 366
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ ++ ++ ++E L L+K AEK+ L+A S++ A I+ R
Sbjct: 367 AEIRHLLERVDQVVREKEKLRSDLDK--AEKLKSLMA-------SEVDDHH---AAIERR 414
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQE 820
+ Y N+ +YK RI L+ + ++R L++ Q QE +KA +E E
Sbjct: 415 NEY--NLRKLDEEYKERIAALKNELR--KEREQILQQAGKQRLELEQEIEKAKTE----E 466
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL--QISLSDMQQHYNA 878
+ + +RLA+ + + +E +LLE EN +K + + + L+ M+ Y
Sbjct: 467 NYIRDRLALSLKENSRLENELLE-NAENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 525
Query: 879 LVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
++ D +SE +Y+ Q R L LK E + L E +
Sbjct: 526 QCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLN 585
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQ 996
+I + V+ + E++ + L +L++ + E L+ V K + +H +
Sbjct: 586 MSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENET 645
Query: 997 QTQSPDYTE--QYINEINKLNALLKQ--------KDEEIIALNQKINNAQVSYMSMV--- 1043
T ++ I E+ A+LK+ +EE L K+ + +
Sbjct: 646 HTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ 705
Query: 1044 --SDYESKLAQFTTKLENMEEEMQ-------RVSKQLLDSKQ-HNEELQILVR----EQD 1089
+ +++L Q E E +Q +V + +Q H E+L LV E++
Sbjct: 706 HEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 765
Query: 1090 DQIKELKE---TKLTFEMNIPKTEGMIISSTIE-PMSDDANNVDXXXXXXXXXXXXLKVQ 1145
+ KEL E +L +TE +S IE D V Q
Sbjct: 766 ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQ 825
Query: 1146 EEEEFIQERSVLQEQSAKLNTEL-QEC-YTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
E ++ +++ + Q EL QEC + + ETL E T V+ QE+ K+
Sbjct: 826 ELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYK 885
Query: 1204 EQLNT---ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
E LN+ E LL + +LR+ + +I EL H +RE + E+ Q
Sbjct: 886 EHLNSMVVERQQLLQDLEDLRNVSETQQSMLSDQILELKSSH--KREL---REREEVLCQ 940
Query: 1261 LSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
A E Q L+ ++ QE +K++ ME + + D+E A++
Sbjct: 941 AGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRER---------AEM 991
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN-----QSYKQMQEQS---IL 1368
+I L+S+I++ + A ++ + Q +Q+ E++ +L
Sbjct: 992 STEISRLQSKIKEMQQATSPLSMLQNGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1051
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
++ + Q K + R+ E L ++ L+ +E + T E T
Sbjct: 1052 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPG-LVMSSCLDEPATEFFGNTAEQTEPFL 1110
Query: 1429 QRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE--IERVK 1486
Q+N R + VE R L+ ++ E+ L + E +ESE +E
Sbjct: 1111 QQN------RTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEAKIEESEASVEGFS 1164
Query: 1487 LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
+E TES L Q+++L + L A + ++ ++ L ++ L+ +
Sbjct: 1165 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERI 1224
Query: 1547 VRASS--SKIQKHVSFASDTKQGR--------DEQLDNTMNKELLDAVPRAELDL 1591
AS + + VS +D Q DE L+N NKEL V R + +L
Sbjct: 1225 PEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALEN--NKELTAEVFRLQDEL 1277
Score = 57.2 bits (132), Expect = 5e-07
Identities = 98/428 (22%), Positives = 191/428 (44%), Gaps = 45/428 (10%)
Query: 464 SLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV-NVKDLIEKLKSAEEQITQLNDEIDAA 522
S + +GT + + + E +KQE K V N+K I +LK +Q+ N E+
Sbjct: 1523 SNLKLGTLYWNSGRMRQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQK 1582
Query: 523 N-KNMIKVKS-NHKLK--LKQMQKTIDNFSKVSDSNKEIVRLTEELHHL----SQKVAEL 574
N +N K++ N +L L Q +K N S + + +E L EEL S V+ L
Sbjct: 1583 NSQNQEKLQELNQRLTEMLCQKEKEPGN-SALEEREQEKFNLKEELERCKVQSSTLVSSL 1641
Query: 575 EEEKGN--LQLHLVDYDSGRMI-ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELH 631
E E +Q H+V ++ + E + K++ +L++ + K S+L S L++E
Sbjct: 1642 EAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVL-SYNEKLLKEKE 1700
Query: 632 ILQQKYDEVEDKLAD-------ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
L ++ + DKLA I+ ++ +Q E +S L+ Q+ A + L ++N
Sbjct: 1701 ALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQN 1760
Query: 685 LKLD----KEQLYGTIKDLENDKEDIMN---KLQN---------YIQENMDLTDKLEKMS 728
+ L K L T ++ E K+++M+ +LQN L ++ +++S
Sbjct: 1761 VNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1820
Query: 729 AEKISELL---AKINHEEQSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEES 784
+K+ L+ ++ +E + QT A++ + +ES L + +
Sbjct: 1821 WDKLDHLMNEEQQLLWQENERSQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1880
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ E + SL+R+ DQ Q++Q + Q + L L + + ++K+ +++
Sbjct: 1881 MNPTEQEKLSLKRECDQ----FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1936
Query: 845 EHENKELQ 852
+ + E+Q
Sbjct: 1937 DEQLMEMQ 1944
>AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a variant
protein.
Length = 1065
Score = 93.9 bits (223), Expect = 4e-18
Identities = 175/891 (19%), Positives = 363/891 (40%), Gaps = 99/891 (11%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
M+ + + + T L + S+ ++ +E K + Q I+ + ERDL
Sbjct: 70 MSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQH-IEQLLAERDLE--- 125
Query: 767 IESELSKYKSRICRLEESIAVMEDRR----YSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
+E++K S + +E+ +A+ D LE K DQL + ++ + ++ E
Sbjct: 126 -RAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADR-------EKVE 177
Query: 823 LVNRLAVLMDHDRVVEKQLLEIEHEN---KELQKKNQILLEENQNLQISLSDMQQHYNAL 879
L+N+L + R VE +E E+ +L+ + ++ + L+ SL + + L
Sbjct: 178 LLNQLE---EEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKL 234
Query: 880 VEKANRTDLAE-SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
+ T +A SE ++ +DL ++ + + L K D+ + +I S
Sbjct: 235 QRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 294
Query: 939 AIRDKKVLNEKYEKNIEYVTQ-LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
+V +++ I + + A+ + ++ I+ L E+L+K N L K
Sbjct: 295 LQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSK------ 348
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQK-INNAQVSYMSMVSDYESKLAQFTTK 1056
E E + + AL K K E IA +Q+ + +VS+ + ++ A+ T+
Sbjct: 349 ------LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 402
Query: 1057 LENMEEEMQRVSKQLL---DSKQ--HNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
+E M + Q + L DS++ H +E++ L + IKE + + + K E
Sbjct: 403 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 462
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ +E M D N K+QE E ++ + E++ + +QE
Sbjct: 463 QHL---VE-MEDTLN----------------KLQEAEIKKEKFAEASEEAVSVQRSMQET 502
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
K+ Q E L+ +E + +++K + + + L+ +L + I+ +
Sbjct: 503 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 562
Query: 1232 GFEIAELWKQH--LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM 1289
G ++L K + L +E D + EL+++L+ L S++ T V
Sbjct: 563 GDNSSQLTKMNDELRLKERDVE----ELQLKLTKANENASFLQKSIEDMT-------VKA 611
Query: 1290 EQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXX 1349
EQ S Q + EE + L+ K +D+ ++E ++ ++ K +
Sbjct: 612 EQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 669
Query: 1350 XDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL 1409
+L Q E + EEN+ L + +A +++ Q+
Sbjct: 670 QNL----QKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDA--MQIMEQM 723
Query: 1410 ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
+ +E + T + +E + +++ + K +E+L KE L + KM E
Sbjct: 724 TKEKTETLASLEDTKQTNAKLQNELDTLKENNL---KNVEELNKSKEL-LTVENQKMEEF 779
Query: 1470 ANHYETMQKES--EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
ET+++ + + +++ ++E NVK+ E + ++ ++ LEEE + N ++
Sbjct: 780 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 839
Query: 1528 NQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+E + + DE + +QK +S S +D +L+ N+
Sbjct: 840 KRESKFIKDADE----------EKASLQKSISITSALLTEKDAELEKLRNE 880
Score = 88.2 bits (209), Expect = 2e-16
Identities = 156/852 (18%), Positives = 371/852 (43%), Gaps = 75/852 (8%)
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSD 552
K +++ L+ + ++ + + + + + H + +++ +D + V
Sbjct: 111 KQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEA 170
Query: 553 SNKEIVRLTEELHHLSQKVAEL----EEE---KGNLQLHL-VDYDSGRMIESDVYKKMIE 604
+++E V L +L +KV +L EEE KG+L+ +++ + +E + + +
Sbjct: 171 ADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTK 230
Query: 605 MENLA----ETRLKAIS----LLESQKFDL---VQELHILQQKYD------EVEDKLADI 647
+ L +TR+ +S ++E +K DL VQE+ L+++ + +V+ L+ +
Sbjct: 231 ADKLQRELEDTRVATVSEKSRIMELEK-DLALRVQEVAELRRRLESNKPAGDVDMSLSLL 289
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
++ S Q E+ + +I +L K+ E + + + LY + L + E +
Sbjct: 290 QEISSLQEKLEVTRTDHQREITSL---KEHFGAREETHQKEIKALYTATEKLSKENESLK 346
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+KL++ +EN D+ L K E + + + E+ K+ G+ + E I
Sbjct: 347 SKLEHANKENSDVI-ALWKSKLE--TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 403
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E Y+ I L+ + R + ++ + L + L + I+E E N L
Sbjct: 404 EKMRLDYQHEIENLQNQ---QDSERAAHAKEMEALRAKLMK--------VIKEKE--NSL 450
Query: 828 -AVLMDHDRVVEKQLLEIEHENKELQK---KNQILLEENQNLQISLSDMQQHYNALVEKA 883
A+ D+ ++ L+E+E +LQ+ K + E ++ MQ+ N L +K
Sbjct: 451 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQRSMQETVNKLHQKE 510
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDK 943
+ ++ S+ K + L D+E+ + + LI K+K D+ +++ +
Sbjct: 511 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 570
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDY 1003
K +N++ V +L+ +L + N L ++E++ + E + K+ +
Sbjct: 571 K-MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT-VKAEQSQQEAAKKHEEEKKE 628
Query: 1004 TEQYINEINKLNALLKQKDEEIIALNQK-INNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
E+ ++++ K + +E+ A ++ + + + ++ + + L KL+ E
Sbjct: 629 LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE 688
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQDD-QIKE---LKETKLTFEMNIPKTEGMIISSTI 1118
E + ++L + ++ E+ + +D QI E ++T+ + K + + +
Sbjct: 689 ENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 748
Query: 1119 EPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKI 1175
+ + ++ N + ++ Q+ EEF +E L++ +A+ + + LQE K+
Sbjct: 749 DTLKEN-NLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 807
Query: 1176 I-QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
+L E+T H + +E+ + L ++L ++ + E ++S+ ++
Sbjct: 808 AEELGRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSI------ 860
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTS 1294
+ L +++A+ +K +E+ V L + + L VQ+ E++K+ +V +
Sbjct: 861 --SITSALLTEKDAELEKLRNEVTV-LRGENASAKSLHSVVQTL---ESDKVKLELKVKN 914
Query: 1295 LQNKLQDKEEHL 1306
L+ +L++ + L
Sbjct: 915 LELQLKENKRQL 926
Score = 87.4 bits (207), Expect = 4e-16
Identities = 142/675 (21%), Positives = 291/675 (43%), Gaps = 75/675 (11%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVN-VKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
T T+ EI ++E K++ + EKL E + + + N ++I
Sbjct: 302 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 361
Query: 529 V-KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
+ KS + + Q+ ++ KVS S L E ++ ++E+ + + Q + +
Sbjct: 362 LWKSKLETAIASHQQAMEEL-KVSFSKG----LGTETAEFAELKTQIEKMRLDYQHEIEN 416
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK-LAD 646
+ + E + K EME L +K I E+ L ++ K D+ ED+ L +
Sbjct: 417 LQNQQDSERAAHAK--EMEALRAKLMKVIKEKENS-------LEAIRSKLDKAEDQHLVE 467
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI 706
+ + +EIK E + + ++ + + L +EQ DLE +E++
Sbjct: 468 MEDTLNKLQEAEIKKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 527
Query: 707 MN---KLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
+ K + + L EK+ + I+E++ K++ + S++ T+ + +++ERD
Sbjct: 528 ADMEAKFREKDEREEQLIKAKEKLEND-IAEIM-KMSGDNSSQL-TKMNDELRLKERD-- 582
Query: 764 IENIESELSKYKSRICRLEESIAVM---------------EDRRYSLERKADQLGSYLQE 808
+E ++ +L+K L++SI M E+ + LERK L ++
Sbjct: 583 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 642
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVE---KQLLEIEHENKELQKKNQILLEENQNL 865
E + + + H+ +++ K LL+ E + K +++N LL+E + L
Sbjct: 643 SHNQCQELKARYERATSETKT--KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 700
Query: 866 QI---------SLSDMQQHYNALVEKANRTDLAESESTKY-----QTQLRDL-ESNLKRI 910
+ + D Q + ++ T LA E TK Q +L L E+NLK +
Sbjct: 701 RKQAEKAKAAQTAEDAMQIMEQMTKEKTET-LASLEDTKQTNAKLQNELDTLKENNLKNV 759
Query: 911 T--HEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
++ + L+ + +++E+ E T ++A + + L+ E+N++ +L E
Sbjct: 760 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 819
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
++ + L LN LE+ K K + + I+ +ALL +KD E+ L
Sbjct: 820 SH-QKLEEERSVLNNQLLEM-KKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 877
Query: 1029 NQKI------NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
++ N + S S+V ES + K++N+E +++ +K+ L S N + Q
Sbjct: 878 RNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE-NKRQLSSSSGNTDTQ 936
Query: 1083 ILVREQDDQIKELKE 1097
++D++ +E ++
Sbjct: 937 ---ADEDERAQESQQ 948
Score = 56.8 bits (131), Expect = 6e-07
Identities = 120/589 (20%), Positives = 240/589 (40%), Gaps = 57/589 (9%)
Query: 147 LSNTIKEKDNALSVLQVKMK--------IMETTILDLQEKINEKDQIIEAKNKATTXXXX 198
L IKEK+N+L ++ K+ ME T+ LQE +K++ EA +A +
Sbjct: 439 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQRS 498
Query: 199 XXXXXXXXXXXXXEDT--KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEA 256
+ + K++EN MEA+++++ +R + I++K+ + + E
Sbjct: 499 MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 558
Query: 257 NKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSL 316
K+ + S + +K+ EL L ++ +E + T+ E S
Sbjct: 559 MKM----SGDNSSQLTKMNDELR---------------LKERDVEELQLKLTKANENASF 599
Query: 317 EIANMTELTKKIELLEHLNC-QIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSG 375
++ ++T K E + + + KELE KL+ + + + + ++ R +
Sbjct: 600 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 659
Query: 376 RNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
T +K + L L+ + K + E + L ++ L K + + +D
Sbjct: 660 -ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQ 718
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV--GTNTEDVNEIAKVQEQLKQELNDEI 493
+TL A L+ Q + + + + N ++V E+ K +E L E N ++
Sbjct: 719 IMEQMTKEKTETL-ASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE-NQKM 776
Query: 494 KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS 553
++ + IE LK A Q +Q + N + + + ++ QK + S +++
Sbjct: 777 EEFRKE--IETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN- 833
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK-------MIEME 606
+L E S+ + + +EEK +LQ + S + E D + ++ E
Sbjct: 834 -----QLLEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKLRNEVTVLRGE 887
Query: 607 NLAETRL-KAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
N + L + LES K L ++ L+ + E + +L+ S Q + ++ +
Sbjct: 888 NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQ 947
Query: 666 EQIDALSASKKELALVIENLKLDKEQ-----LYGTIKDLENDKEDIMNK 709
+ ID L++ +L ++LK+ E L G DL N D K
Sbjct: 948 QMIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEK 996
>AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein.
Length = 1559
Score = 93.9 bits (223), Expect = 4e-18
Identities = 172/830 (20%), Positives = 347/830 (41%), Gaps = 80/830 (9%)
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHD 834
C L +ME L R+ ++ + L +K+ + ++ ++ E +L +
Sbjct: 7 CALLGEETMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLK 66
Query: 835 RVVEKQLLEIE----------HENKELQKKNQILLEENQNLQISLSD--MQQHYNALVEK 882
R +E+ +E+ H+ +E +K Q + E+ Q+ M Q LV
Sbjct: 67 RSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSA 126
Query: 883 ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI-EDLEIE-FNTQIESAI 940
R+DL ESE + + + + H+ Q K E+ E ++E N + + I
Sbjct: 127 RRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKI 186
Query: 941 RDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS 1000
++ L EK EK ++ T+ LQ + E +E+L N E + ++K+ ++
Sbjct: 187 QE---LQEKLEKAVKASTEATELLQNIRQAKERAERELEKL--QNREDSSEGIRKKLVEA 241
Query: 1001 PDYTEQYIN---EINKLNALLKQK----DEEIIALNQKINN---AQVSYMSMVSDYESK- 1049
+ E++ L LKQK +E+I L+ +I + + +M+ +E +
Sbjct: 242 EELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 301
Query: 1050 ------LAQFTTKLENMEEEMQRVSKQLLDSKQHNE-------ELQILVREQDDQIKELK 1096
L++ + M+ +++ + +++++ + N+ Q ++ Q++ I EL+
Sbjct: 302 HEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELR 361
Query: 1097 ETKLTFEMNIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-E 1153
+ K E K E + +E +S ++ + ++ EE+ ++ +
Sbjct: 362 QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELK 421
Query: 1154 RSV------LQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
R + LQE+ ++L T LQ + QL TEL +E+I L + +++
Sbjct: 422 RQLTELQLSLQERESQL-TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEI 480
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL-AQREADFQKTEHELRVQLSAFE 1265
+ D L ++ + + + ++Q + AEL Q+ ++ D ++ VQL
Sbjct: 481 QRKFDALRNSCTVI-TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQL---R 536
Query: 1266 SKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
S+ + L + + T++ TME + + L+++ L L ++ + Q E RS
Sbjct: 537 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRS 596
Query: 1326 EIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ---LKKSSX 1382
+ DEK F +Q + ++ L + E A+ L+++
Sbjct: 597 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALK 656
Query: 1383 XXXXXXXXXXXRVNDAEAK--VLEL-THQLELK---DSEIYQKTHEYTITLTQRNDEFEN 1436
++ND E K +LE+ L+ K + E+ Q+ E L Q+ D +N
Sbjct: 657 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 716
Query: 1437 ----VRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN 1492
+ Q L E R DL + S+L + +H + + + ++ KLI+ L
Sbjct: 717 HIFRLTQGLQEALDR-ADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQ 775
Query: 1493 VKITESVSLNK---QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
K+ + K Q EL ALE+E A+ E++ AL+ IE+ + +E
Sbjct: 776 AKMDQPAKKKKVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREE 825
Score = 90.2 bits (214), Expect = 5e-17
Identities = 143/794 (18%), Positives = 329/794 (41%), Gaps = 49/794 (6%)
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
+VS + + ++L ++ S+K+ E++E++ Q+ + ++ E V + +L
Sbjct: 75 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSAR--RRSDL 132
Query: 609 AETRLKAISLL-ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E+ L+ L E K + H L + D+ + ++ + ++L+ ++K L+E+
Sbjct: 133 YESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 192
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
++ + E +++N++ KE+ ++ L+N +ED ++ + E ++LE
Sbjct: 193 LEKAVKASTEATELLQNIRQAKERAERELEKLQN-REDSSEGIRKKLVE----AEELE-- 245
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
EK E H E Q + + KI+ D I+ +L+ +E++
Sbjct: 246 --EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLAD--------KETLEN 292
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
M R E +A + G L E++ + + L R+ L + +++ L +
Sbjct: 293 MMQRH---EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRN 349
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
K ++ L ++ L+ ++ L E+ + + S K +L +LE+ L
Sbjct: 350 MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS-HQDHSDK--NRLLELETRL 406
Query: 908 KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-TQLEAQLQE 966
+ ++ EH+ ++ K+++ +L++ + ES + + E + T+LE E
Sbjct: 407 REVSLEHEEQKLELKRQLTELQLSLQER-ESQLTALQAARAALESQLRQAKTELEETTAE 465
Query: 967 YKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+ I+ L + +E+ + L + + + Q TE E+N N L ++ +E
Sbjct: 466 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA-ELNNQNFYLSKQLDE 524
Query: 1025 IIALNQKI--NNAQVSYMSM-VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
N +I ++V ++ +++ E +L +E ++ + +Q++D + N+EL
Sbjct: 525 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDEL 584
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
R+ + L + K FE + + + M ++ D
Sbjct: 585 LEKERQWEAWRSVLGDEKSQFECRVRELQRM-----LDTEKQSRARADQRITESRQVVEL 639
Query: 1142 LKVQEEEEFIQERSVLQEQSAK---LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
+ + E + + L+EQ K L+ +L + K LE +N + + ++ Q
Sbjct: 640 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE-MNARSLQQKLETERELKQ 698
Query: 1199 -LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL 1257
L + +L + D + + L + A+D+ ++ + + L + + Q
Sbjct: 699 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA--DLLKTERSDLEYQLENIQVLYSHE 756
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
+V++ S+ +L+D +Q+ + K Q L+ L+ ++ L+E
Sbjct: 757 KVKMEGTISQQTKLIDFLQAKMDQPAKKKKVPLQYNELKLALEKEKARCAELEEALQKTR 816
Query: 1318 NQIEILRSEIEDEK 1331
++ R E K
Sbjct: 817 IELRSAREEAAHRK 830
Score = 75.4 bits (177), Expect = 2e-12
Identities = 141/731 (19%), Positives = 305/731 (41%), Gaps = 55/731 (7%)
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
KN LL E ++ +M + + + E E E +TQ LE +L E
Sbjct: 5 KNCALLGEETMME---QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITE 61
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ-LEAQLQEYKNNIE 972
+L K+ +E +E + + + A++ + E+ K E Q +AQ++E + +
Sbjct: 62 CSSL----KRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMN 117
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI--IALNQ 1030
L ++ + + +L + +++ + + ++ + +KL Q E+ A +
Sbjct: 118 QLEEDLVSARRRS-DLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 176
Query: 1031 KINNAQVSYMSMVSDYESKLAQFTTK----LENMEEEMQRVSKQLLDSKQHNEELQILVR 1086
KIN Q + + + K + +T+ L+N+ + +R ++L + Q+ E+ +R
Sbjct: 177 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL-EKLQNREDSSEGIR 235
Query: 1087 EQDDQIKELKETKLTFEMNIPKTEGMIISST--IEPMSDDANNVDXXXXXXXXXXXXLKV 1144
++ + +EL+E +++ E + E +N +
Sbjct: 236 KKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQ 295
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
+ EEE ++ +L EQ A +N +KI LE EL+ N+ N S
Sbjct: 296 RHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSE---ANKLAANS--SLFT 346
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
Q N + + ++ELR Q G E + L ++ +H + +L
Sbjct: 347 QRNMKAQEEM--ISELRQQKFYLETQAGK--LEAQNRKLEEQLEKISHQDHSDKNRLLEL 402
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILR 1324
E++ ++ S + E K+ Q+T LQ LQ++E L LQ A + +Q+ +
Sbjct: 403 ETRLREV------SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 456
Query: 1325 SEIED---EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
+E+E+ E LR ++EQ + + E+NA+L +
Sbjct: 457 TELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQ-LNQLTEDNAELNNQN 515
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI---TLTQRNDEFENVR 1438
+ A ++++L +++ EI ++ + T T+ +
Sbjct: 516 ----FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE 571
Query: 1439 QQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITES 1498
+Q+++ E + D EKE + R + + + +E +E + + ++ + +
Sbjct: 572 EQVMDLE-ALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ-RMLDTEKQSRARADQR 629
Query: 1499 VSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN---MVRASSSKIQ 1555
++ ++QV EL A++E A+ +Q AL+ Q+++ +L+D++ +L+ M+ ++ +Q
Sbjct: 630 ITESRQVVEL--AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ 687
Query: 1556 KHVSFASDTKQ 1566
+ + + KQ
Sbjct: 688 QKLETERELKQ 698
Score = 72.9 bits (171), Expect = 9e-12
Identities = 129/624 (20%), Positives = 277/624 (44%), Gaps = 76/624 (12%)
Query: 472 TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEE-QITQLNDEIDAANK---NMI 527
TE +++ K ++Q K E+ + K +EK+ + ++ +I +L ++++ A K
Sbjct: 152 TECQHKLLKAKDQGKPEVGEYAK-------LEKINAEQQLKIQELQEKLEKAVKASTEAT 204
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD 587
++ N + ++ ++ ++ DS++ I + E L +K E + +L++HL
Sbjct: 205 ELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHL-- 262
Query: 588 YDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
+ E +K+ ++N + L LE +++Q+ +E +K +
Sbjct: 263 ----KQKEQHYEEKIKVLDNQIKKDLADKETLE----------NMMQRHEEEAHEKGKIL 308
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
S+ ++ + K LE++I LS + K A L+ T ++++ +E+++
Sbjct: 309 SEQKAMINAMDSKIRSLEQRIVELSEANKLAA---------NSSLF-TQRNMK-AQEEMI 357
Query: 708 NKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
++L+ Q+ L + K+ A+ K+ E L KI+H++ S ++ ++ R++ +E
Sbjct: 358 SELR---QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL--REVSLE 412
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ E +L + K ++ L+ S+ E + +L+ L S L++ + E T + +E +
Sbjct: 413 HEEQKL-ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQ 471
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
L D EI+ + L+ ++ + + L D + N + +
Sbjct: 472 ALTAHRD----------EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 521
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
D A + + QLR +L+R E + + +K+ +E L+ T +E + D +
Sbjct: 522 LDEASGANDEI-VQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC-TMLEEQVMDLEA 579
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
LN++ +E Q EA + V EL +M +D + QS +
Sbjct: 580 LNDEL---LEKERQWEAWRSVLGDEKSQFECRVRELQRM----LD-----TEKQSRARAD 627
Query: 1006 QYINEINKLNAL-LKQKDEEIIALNQKINNAQVSYMSM---VSDYESKLAQFTTKLENME 1061
Q I E ++ L +K+ EI+AL Q + ++ S+ ++D E K A +++
Sbjct: 628 QRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ 687
Query: 1062 E--EMQRVSKQLLDSKQHNEELQI 1083
+ E +R KQ L +Q + Q+
Sbjct: 688 QKLETERELKQRLLEEQAKLQQQM 711
Score = 70.1 bits (164), Expect = 6e-11
Identities = 164/823 (19%), Positives = 323/823 (39%), Gaps = 59/823 (7%)
Query: 243 IESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEP 302
+ K+V + + E LLE E S L + LEQ L E
Sbjct: 34 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQ 93
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTN---KEL-ENKLATMGTESKA 358
S + + E++ ++ M + ++E E L R+++ EL E++LA + KA
Sbjct: 94 SRKLQEIKEQEYQAQVEEMRLMMNQLE--EDLVSARRRSDLYESELRESRLAAEEFKRKA 151
Query: 359 VSSPSK--KGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS 416
K K + G + + QL + L + +K + + + ++Q+
Sbjct: 152 TECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKAS--TEATELLQN 209
Query: 417 LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN 476
+ + KE E + + L+ +LE + S H+ + +
Sbjct: 210 IRQ---AKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKE 266
Query: 477 EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLK 536
+ +E++K N KD+ K+ +E + E+ +I + K MI +
Sbjct: 267 Q--HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRS 324
Query: 537 LKQMQKTIDNFSKVSDSN-----KEIVRLTEELHHLSQKVAELEEEKGNL--QLHLVDYD 589
L+Q + +K++ ++ + + E + L Q+ LE + G L Q ++
Sbjct: 325 LEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 384
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISL-LESQKFDLVQELHILQQKYDEVEDKLADI- 647
++ D K +E ETRL+ +SL E QK +L ++L LQ E E +L +
Sbjct: 385 LEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 442
Query: 648 -------SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
SQL+ + E + EE+I AL+A + E+ + L+ I DLE
Sbjct: 443 AARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR----NSCTVITDLE 498
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSA--EKISELLAKINHEEQSKIQTQFGIDAKIQ 758
+ +N L+ +L++ S ++I +L ++++H + +I
Sbjct: 499 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDH-----------LRREIT 547
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
ER++ + + + + K+ LEE + +E L K Q ++ S++
Sbjct: 548 EREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEC 607
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
+ EL R+ R Q + + EL K E LQ +L + + +
Sbjct: 608 RVREL-QRMLDTEKQSRARADQRITESRQVVELAVKEH--KAEILALQQALKEQKLKAES 664
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
L +K N DL E + + R L+ L+ Q L+ ++ K + ++++ N
Sbjct: 665 LSDKLN--DL-EKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRL 721
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
++ L+ E + LE QL+ + + + +E +LID +Q +
Sbjct: 722 TQGLQEALDRADLLKTER-SDLEYQLENIQVLYSHEKVKMEGTISQQTKLID-FLQAKMD 779
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMS 1041
Q P ++ + N+L L+++ L + + ++ S
Sbjct: 780 Q-PAKKKKVPLQYNELKLALEKEKARCAELEEALQKTRIELRS 821
Score = 44.0 bits (99), Expect = 0.005
Identities = 108/542 (19%), Positives = 218/542 (40%), Gaps = 54/542 (9%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILDL-QEKINEKDQI--IEAKNKATTXXXXXX 200
+ LS K N+ Q MK E I +L Q+K + Q +EA+N+
Sbjct: 329 IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 388
Query: 201 XXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL 260
K ++ +++ + E +++K L + + + + E L
Sbjct: 389 SHQD-------HSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTAL 441
Query: 261 EAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN 320
+AAR + + + ELE+ A++ I+ + EI+ K +
Sbjct: 442 QAARAALESQLRQAKTELEETTAE-----------AEEEIQALTAHRDEIQRKFDALRNS 490
Query: 321 MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLIS-RKSGRNTA 379
T +T +L E LN Q+ + N EL N+ + SK + S ++ R +
Sbjct: 491 CTVIT---DLEEQLN-QLTEDNAELNNQNFYL---SKQLDEASGANDEIVQLRSEVDHLR 543
Query: 380 SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISE-KDTXXXXX 438
++ QL+S+ + K + + M +++LN +L++KE +
Sbjct: 544 REITEREMQLTSQKQTMEA-LKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEK 602
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLK-QELNDEIKDVN 497
L L E Q I T + V E+A + + + L +K+
Sbjct: 603 SQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILALQQALKEQK 659
Query: 498 VK--DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+K L +KL E++ L E++A + K+++ +LK + +++ ++
Sbjct: 660 LKAESLSDKLNDLEKKHAML--EMNARSLQQ-KLETERELKQRLLEEQAKLQQQMDLQKN 716
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
I RLT+ L + L+ E+ +L+ L + I+ + ++ME + K
Sbjct: 717 HIFRLTQGLQEALDRADLLKTERSDLEYQLEN------IQVLYSHEKVKMEGTISQQTKL 770
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSAS 674
I L++ K D + + +Y+E+ KLA L+ ++ C+E++ + +I+ SA
Sbjct: 771 IDFLQA-KMDQPAKKKKVPLQYNEL--KLA----LEKEKARCAELEEALQKTRIELRSAR 823
Query: 675 KK 676
++
Sbjct: 824 EE 825
Score = 40.3 bits (90), Expect = 0.056
Identities = 44/244 (18%), Positives = 103/244 (42%), Gaps = 18/244 (7%)
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL-ELKDS 1414
+++ + + EQ + E + LK+S + + E + +L E+K+
Sbjct: 44 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ 103
Query: 1415 EIYQKTHEYTITLTQRNDEFENVRQQ--LVEYEKRIEDLTYEK------ESELAILRLKM 1466
E + E + + Q ++ + R++ L E E R L E+ E + +L+ K
Sbjct: 104 EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKD 163
Query: 1467 H--ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQT 1524
Y ++K + +++K I+EL K+ ++V + + EL + + + +
Sbjct: 164 QGKPEVGEYAKLEKINAEQQLK-IQELQEKLEKAVKASTEATELLQNIRQAKERAERELE 222
Query: 1525 ALENQEIEIVTLNDEITNLQNM------VRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+N+E + ++ + + + S+ ++ H+ + + + LDN + K
Sbjct: 223 KLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKK 282
Query: 1579 ELLD 1582
+L D
Sbjct: 283 DLAD 286
>AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and
Golgi-localized PKN-associated protein (CG-NAP) protein.
Length = 3899
Score = 93.9 bits (223), Expect = 4e-18
Identities = 175/932 (18%), Positives = 401/932 (43%), Gaps = 85/932 (9%)
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E +D L+ E ++E+++ E + E+ E ++Q +A I++
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRE-LEEMRVTYGTEGLQQLQE---FEAAIKQ 202
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
RD I + + L + + + ++ L+ + QL + + +S
Sbjct: 203 RDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA- 261
Query: 820 EDELVNRLAVLMDHDRVVEKQ--LLEIEHENKE--------LQKKNQIL-LEENQNLQIS 868
+L+ ++ H + +E+Q LLE + KE LQ+K ++ +E+++ ++ S
Sbjct: 262 --DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENS 319
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ Q ++E+ N T + E E K +L+D + ++ E Q IVQK +EI+++
Sbjct: 320 NKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLE 987
++E + + + + + E + Q + ++ + + +L ++ E
Sbjct: 377 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 436
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQVSYMSM-VS 1044
L + + Q+ + Q++ ++ ++ K + E + N +N Q+ M++ ++
Sbjct: 437 LDEMYGQQIVQMKQELIRQHMAQMEEIKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 496
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ KL ++ E ++EE+ + ++ ++ E+L + QI+ ++T E
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRGQIQRARQTIAEQES 556
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + + ST+E + + L+++ E E + L+ +
Sbjct: 557 KLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKIKLEMLEKEK 607
Query: 1165 NTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN--DNLLSTVA 1218
N L ++ +LE L+T+L ++E++++LK LE +++ E DNL
Sbjct: 608 NAVLDRMAESQEAELERLSTQLL---FSHEEELSKLKEDLEIEHRISIEKLKDNLGIHYK 664
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKYEQL---LDS 1274
+ + + + Q+ E + K +L ++ +L+ +Q S SK E++ ++
Sbjct: 665 QQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 1275 VQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q QEE K ++V LQ K + E+ ++ + + Q+E S ++DE
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Query: 1331 KVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
K +++S + E+ I + EEN LK+
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
+ AE K E+ +Q EL++ EY L ++D ++ +Q +EY+ ++
Sbjct: 844 EKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNKQELEYKSKL 893
Query: 1449 ----EDLTYEKESELAI-LRLKMHENANHY--ETMQKESEIER--VKLIEELNVKITESV 1499
E+L ++ + + ++ + + + ET++ +E+ +L+E L V E +
Sbjct: 894 KALNEELNLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMENLEVTKREKL 953
Query: 1500 SLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L++++++L++ L+ EEV K + Q +L +E+EI+ ++ ++Q+
Sbjct: 954 ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAEDVQSCD 1013
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
SS + V+ S +G +++ + +E
Sbjct: 1014 TQESSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045
Score = 91.5 bits (217), Expect = 2e-17
Identities = 284/1471 (19%), Positives = 603/1471 (40%), Gaps = 145/1471 (9%)
Query: 232 WKDEKQRLLKDIESKDVRISSLEE-----ANKL--LEAARFEISLEHSKLAQELE----Q 280
+ DEK + I+ K I LE+ +N+L LEA + +I E L+++ E +
Sbjct: 1927 YADEKTLFERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE 1986
Query: 281 XXXXXXXXXXXXXXLAKQSIEPSCE-EKTEIE---EKGSLEIANMTELTKKIELLEHLNC 336
L K+ +E C+ EK + + +LEI ++++ IEL + N
Sbjct: 1987 AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT 2046
Query: 337 QI---RQTNKELENKLATMGT--ESKAVSSPSKKG--SPLISRKSGRNTASKMKSPWSQL 389
++ RQ N+ LE +L M + +A+ ++ I + + P S+
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH 2106
Query: 390 SS---ETLNQDTDKKINK-NEIA----KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXX 441
+ E L +K +K +E+ +L+ IQ N+++ E+ + E
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELVQALLVEDRK 2166
Query: 442 XXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL---NDEIKDVNV 498
G +L LE Q E + + +++ + + EQ ++EL N+E++ +++
Sbjct: 2167 HFGAVEAKPELSLEVQLQAERDA---IDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2223
Query: 499 KDLIEKLKSAE--EQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SDSN 554
+ I+K +S +++ Q N D K + +K + + + F+++ +
Sbjct: 2224 QLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
EI +L E++ L Q++ + K + + + D +E+ + M + E + R +
Sbjct: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD----LETQIECLMSDQECVKRNREE 2339
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKL---ADISQLQSDQVCSEIKSVHLEEQIDAL 671
I L L QEL + QK L AD + Q D V +E + LE+Q++
Sbjct: 2340 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE--KLALEQQVETA 2397
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
+ + V++ QL + L+ ++E + K+Q+ + ++++ ++ +S +K
Sbjct: 2398 NEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV-EKIQSIPENSVNVA--IDHLSKDK 2454
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC----RLEESIAV 787
EL + + ++ Q + + I N+E+ L + +S + L +
Sbjct: 2455 -PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLRQLESTVSAKDLELTQCYKQ 2513
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE-KQLLEIEH 846
++D + + + + L + QK E +L + ++ + + Q + E
Sbjct: 2514 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2573
Query: 847 ENKELQKKNQILLEENQN----LQISLSDMQQH----YNALVEKANRTDLAESESTKYQT 898
E +Q NQ+ +E + L + +S+++ + +L+ + + ++AE + +
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYV 957
+L +L+ L+ +E + +KK+ +D+E+ + T++ + + NE E V
Sbjct: 2634 KLLELQKLLEG--NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESV 2691
Query: 958 TQLEAQLQEYKNNIENLN--MNVEELNKMNLEL----IDKHVQKQQT-----QSPDYTEQ 1006
+A+L YK E L + V+E N +L+ + H+ + + + D TE
Sbjct: 2692 AT-KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEV 2750
Query: 1007 YINE---------INKLNALLKQKDE--EIIALNQK----INNA--QVSYMSMVSDYESK 1049
++ I ++ Q D +I + NQ + NA Q++ S S E
Sbjct: 2751 QESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810
Query: 1050 --LAQFTTKLENMEE---------EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKET 1098
++QFT K+E M+E E + +S+ ++H +Q+L +E+ +K + +
Sbjct: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLL-KEECGTLKAVIQC 2869
Query: 1099 KLTFE-MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVL 1157
+ E +IP+ T E S D+ + D + E + S
Sbjct: 2870 LRSKEGSSIPELAHSDAYQTREICSSDSGS-DWGQGIYLTHSQGFDIASEGRGEESESAT 2928
Query: 1158 QEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV 1217
K+ L+ + +Q+ +L TE D I Q+ E E ++T+
Sbjct: 2929 DSFPKKIKGLLRAVHNDGMQVLSL-TESPYSD-GEDHSIQQVS---ESWLEERKAYINTI 2983
Query: 1218 AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQS 1277
+ L+ I+ QR E+ + + H + +D+ + E L +Q E + L
Sbjct: 2984 SSLKDLITKMQLQREAEVYDSSQSH--ESFSDW-RGELLLALQQVFLEERSVLLAAFRTE 3040
Query: 1278 STQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE--KYAD---VINQIEILRSEIEDEKV 1332
T T V + + L+ ++Q++ + E AD ++++I+ L +++ K+
Sbjct: 3041 LTALGTTDAVGL--LNCLEQRIQEQGVEYQAAMECLHKADRRSLLSEIQALHAQMNGRKI 3098
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+++ + +MQ + + ++ + +L++
Sbjct: 3099 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVE-LSSMKDRATELQEQLSSEKMVVAELK 3157
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
+ A+ K LEL L+ + + ++ + + + + DE + L K+ +L
Sbjct: 3158 SEL--AQTK-LELETTLKAQHKHL-KELEAFRLEVKDKTDEVHLLNDTLASEHKKSRELQ 3213
Query: 1453 YEKESELAILRLKMHENANHYETM------QKESEIERVKLIEELNVKITES-VSLNKQV 1505
+ E E A L + E + QK+ ++ L+E+ + ES + Q
Sbjct: 3214 WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQR 3273
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLN---DEITNLQNMVRASSSKIQKHVSFAS 1562
+ L EE + E+Q L++Q++ I ++ D L +++S Q S
Sbjct: 3274 MLYDAQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3333
Query: 1563 -DTKQGRDEQLDNTMNK--ELLDAVPRAELD 1590
D + +QL+ ++ ELL+ + +LD
Sbjct: 3334 EDLLKELQKQLEEKHSRIVELLNETEKYKLD 3364
Score = 89.4 bits (212), Expect = 9e-17
Identities = 185/947 (19%), Positives = 388/947 (40%), Gaps = 71/947 (7%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 471 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 529
Query: 207 XXXXXEDTKQQMTKMQE--NFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
E+ ++Q IA + +E + L +E I S E+ K LE +
Sbjct: 530 LEDLVEELSFSRGQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELEL-K 588
Query: 265 FEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIAN 320
E + + K+ E+ E+ L + S + + E+ + K LEI +
Sbjct: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKLKEDLEIEH 648
Query: 321 MTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRNT 378
+ K K L H QI E+ K+ TM E + + + IS+ K + +
Sbjct: 649 RISIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQS 708
Query: 379 ASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX 437
KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 709 LVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Query: 438 XXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN 497
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 769 KFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEKE 821
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 822 IEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLED 880
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAIS 617
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 881 SKNKQELEYKS-KLKALNEE---LNLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMGE 932
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
++E +L++ L + +++ E+ +L+D+S+ Q Q EI L E++ +L K++
Sbjct: 933 VVEKDTTELMENLEVTKREKLELSQRLSDLSE-QLKQKHGEIS--FLNEEVKSLKQEKEQ 989
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
++L L++ N ED+ Q+ + L D + M++ ++
Sbjct: 990 VSLRCRELEIIIN---------HNRAEDV----QSCDTQESSLLDGVVTMTSRGAEGSVS 1036
Query: 738 KINHE--EQSKIQTQ-------FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVM 788
K+N E+SKI + + + ++ L ++++ S + R + E+ +
Sbjct: 1037 KVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQ 1096
Query: 789 EDRRYSLERKADQLGSYLQEKQKAYS-EYTIQEDELVNRLAVLMDHD--RVVEKQLLEIE 845
++ L+ + + L ++ ++ S Y+ D++ + D + E+ + E
Sbjct: 1097 KELNV-LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQE 1155
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE---------SESTKY 896
+ KELQK +Q+ L+ + + D + + L+ K + E S +Y
Sbjct: 1156 EKIKELQKIHQLELQTMKTQE--TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEY 1213
Query: 897 QTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
T E N + + + + E++D E E+ + E+Y K +
Sbjct: 1214 YTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
T+L +++ + + L E L K E + H Q T D + ++++ L
Sbjct: 1274 QTRL-SKIWGQQTDGMKLEFGEENLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSLQD 1330
Query: 1017 LLKQK-DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
L K K +E++ L I++ Q +YE+++ +L+ + E
Sbjct: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377
Score = 87.0 bits (206), Expect = 5e-16
Identities = 164/819 (20%), Positives = 360/819 (43%), Gaps = 94/819 (11%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQI 512
QLEH + + + ++ E K QE+L++ L++E + + L +L AE I
Sbjct: 1867 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR--AREQLAVELSKAEGVI 1924
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
DE + I+ K++ +L+Q N ++ + E ++ EE LS++
Sbjct: 1925 DGYADE-KTLFERQIQEKTDVIDRLEQELLCASN--RLQELEAEQQQIQEERELLSRQKE 1981
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
++ E G ++ L+ E E L + +L+ E + DL +++
Sbjct: 1982 AMKAEAGPVEQQLLQ----------------ETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2025
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+ +VE++++ +L+ ++ + + L +Q AL +++ ++ +D+E
Sbjct: 2026 LE---IDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH- 2078
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKIQTQF 751
+ D+ + +++ + + + + +S + E+ NH +E++ ++
Sbjct: 2079 ----------ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY--SLERKAD-QLGSYLQE 808
+ + +RD+ N E+ K + R+ L +++ V EDR++ ++E K + L LQ
Sbjct: 2129 LLSKEQLQRDIQERN--EEIEKLEFRVRELVQALLV-EDRKHFGAVEAKPELSLEVQLQA 2185
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
++ A +E E+ N + +E+ E+E++N+E+Q+ + L + +
Sbjct: 2186 ERDAIDR---KEKEITNL-------EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2235
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIED 927
L +++Q + + LA ES TQ + L +I E + I Q +++
Sbjct: 2236 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2295
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
L+ Q D KV+ EK E + TQ+E + + + N +E+LN++ +E
Sbjct: 2296 LQ-----QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV-IE 2349
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN--NAQVSYM-SMVS 1044
+ + + ++ E + L L E +AL Q++ N ++++M +++
Sbjct: 2350 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLK 2409
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSK-QLLDSKQHNEELQILVREQ--------DDQIKEL 1095
+ K+ Q T +L +++ E + V K Q + N + L +++ +D +K L
Sbjct: 2410 ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL 2469
Query: 1096 KETKLTFEMNIPKTEGMIIS--STIEPMSDDANNVDXXXXXXXXXXXXLKVQE--EEEFI 1151
E + F+ +G II+ + + + + D ++ Q E E +
Sbjct: 2470 -ENQTYFKSFEENGKGSIINLETRLRQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2528
Query: 1152 QER-----SVLQEQSA-----KLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQI--NQ 1198
Q++ +++E+ A ++ E + Y K Q +T+++E ++ N Q+ ++
Sbjct: 2529 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2588
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
L S + L L S V E+ +S+ +++ EIAE
Sbjct: 2589 LGSDISALTLRISELESQVVEMHTSL--ILEKEQVEIAE 2625
Score = 75.8 bits (178), Expect = 1e-12
Identities = 175/951 (18%), Positives = 394/951 (41%), Gaps = 73/951 (7%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS----ASKKELALVIENLKLD 688
LQ++ + +LA S + ++ + SE + V LEE ++AL A +++L + N
Sbjct: 1626 LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE-LEALKQLSLAGREKLCCELRNSSTQ 1684
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENM--DLTDKLEKMSAEKISELLAKINHEEQSK 746
+ G E +++ K + E++ ++ E+ + +K + L KI E
Sbjct: 1685 TQN--GNETQGEGEEQTFKEKELDRKPEDVPPEILSN-ERYALQKANNRLLKILLE---V 1738
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
++T ++ I L I + S+ S I R E +V R D
Sbjct: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD------ 1792
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN-QILLEENQNL 865
E +YS + ++ +N + + + + ++L+ E+ +N +++L + L
Sbjct: 1793 -ESIPSYSGSDMPRND-INMWSKVTEEGTELSQRLVRSGFPGTEIDPENEELMLNISSRL 1850
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q ++ + + + + + ++E + + + + + E + + ++ +
Sbjct: 1851 QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAR 1910
Query: 926 EDLEIEFNTQ---IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELN 982
E L +E + I+ +K + + ++ + + +LE +L N ++ L +++
Sbjct: 1911 EQLAVELSKAEGVIDGYADEKTLFERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQ 1970
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ EL+ + + + ++ +Q + E K L+K+K E + ++ Q ++
Sbjct: 1971 E-ERELLSRQKEAMKAEAGPVEQQLLQETEK---LMKEKLEVQCQAEKVRDDLQKQVKAL 2026
Query: 1043 VSDYESKLAQF-------TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
D E ++++F T+L ++ ++ Q + KQL ++ +E Q + RE + + +
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAIDREHERDVFQQ 2085
Query: 1096 KETKLTFEMN-IPKTEGMIISST--IEPMSDDANNVDXXXXXXXXXXXXLK--VQEEEEF 1150
+ KL ++ +P+ + + T +E +++ L+ +QE E
Sbjct: 2086 EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145
Query: 1151 IQERSV-LQEQSAKLNTELQECYTKIIQLETLNTEL---TGHDVVN--QEQINQLKSKLE 1204
I++ ++E L E ++ + + L+ E+ D ++ +++I L+ +LE
Sbjct: 2146 IEKLEFRVRELVQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
Q E +N V +L + + + EL +++ ++ D +K ++ +
Sbjct: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD-DMEKLGLAIKESDAMS 2264
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQDKEEH--LRNLQEKYADVINQIE 1321
L QE+ +I + EQVT LQ +L+ ++ + E D+ QIE
Sbjct: 2265 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIE 2324
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
L S+ E K L+ E + Q + +++EE LK
Sbjct: 2325 CLMSDQECVK----RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQL 2380
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
+V A ++ + + L+ + ++ Q T E +L + + E + Q +
Sbjct: 2381 DVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQE-LFSLKRERESVEKI-QSI 2438
Query: 1442 VE--YEKRIEDLTYEK-ESELAILR--LKMHENANHYETMQKESEIERVKLIEELNVKIT 1496
E I+ L+ +K E E+ + LK EN ++++ ++ + + L E ++
Sbjct: 2439 PENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINL--ETRLRQL 2496
Query: 1497 ESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
ES K + EL + ++ +MQ E + E L +I NLQ +V
Sbjct: 2497 ESTVSAKDL-ELTQCYKQ----IKDMQ---EQGQFETEMLQKKIVNLQKIV 2539
Score = 75.4 bits (177), Expect = 2e-12
Identities = 219/1169 (18%), Positives = 480/1169 (41%), Gaps = 82/1169 (7%)
Query: 387 SQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVIS-EKDTXXXXXXXXXXGK 445
+Q+ +Q+ K+ + EI +L VI+ L ++L + S +
Sbjct: 2321 TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQL 2380
Query: 446 DTLIAQ-LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
D +IA+ L LE Q + + ++ N QL QEL ++ ++ +EK
Sbjct: 2381 DVVIAEKLALEQQVETANEEMTFMKNVLKETNF---KMNQLTQELFSLKRE---RESVEK 2434
Query: 505 LKSA-EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEE 563
++S E + D + + V + LK + Q +F + + I+ L
Sbjct: 2435 IQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE--NGKGSIINLETR 2492
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY-KKMIEMENLAETRLKAISLLESQ 622
L L V+ + E + D E+++ KK++ ++ + E ++ A +L+
Sbjct: 2493 LRQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAA-ALVSQI 2551
Query: 623 KFDLVQELHILQQKYDEVEDK-----LADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
+ + VQE Q + + + +++QL+ D++ S+I ++ L +S + +
Sbjct: 2552 QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR-----ISELESQ 2606
Query: 678 LALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLA 737
+ + +L L+KEQ+ K++ +KE + +LQ ++ N + EK + + E+L
Sbjct: 2607 VVEMHTSLILEKEQVEIAEKNVL-EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
S ++ F + + + ++EL+ YK + +L+E + V E SL++
Sbjct: 2666 TTTELFHSNEESGFFNELEALRAESVAT--KAELASYKEKAEKLQEELLVKETNMTSLQK 2723
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELV--NRLAVLMDHDRV-VEKQLLEIEHENKELQKK 854
Q+ +L E ++ S +++ V ++ A + + + + K + ++
Sbjct: 2724 DLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS 2783
Query: 855 NQI--LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITH 912
NQ +L +N +QI+L + T+ E + ++ D+ES R
Sbjct: 2784 NQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMES---RHIS 2840
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA-QLQEYKNNI 971
E +TL + ++ L+ E T +++ I + L K +I + +A Q +E ++
Sbjct: 2841 ETETLKREHYVAVQLLKEECGT-LKAVI---QCLRSKEGSSIPELAHSDAYQTREICSSD 2896
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ + + + + D + + +S T+ + +I L + ++++L +
Sbjct: 2897 SGSDWG-QGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNDGMQVLSLTES 2955
Query: 1032 -INNAQVSYMSMVSD--YESKLAQFTT--KLENMEEEMQ-RVSKQLLDSKQHNEELQILV 1085
++ + + VS+ E + A T L+++ +MQ + ++ DS Q +E
Sbjct: 2956 PYSDGEDHSIQQVSESWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWR 3015
Query: 1086 REQDDQIKELKETKLTFEMNIPKTEGMIISST--IEPMSDDANNVDXXXXXXXXXXXXLK 1143
E ++++ + + + +TE + +T + ++ + L
Sbjct: 3016 GELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLH 3075
Query: 1144 VQEEEEFIQERSVLQEQ--SAKLNTELQECYTKIIQ--LETLNTELTGHDVVNQEQINQL 1199
+ + E L Q K+ + ++ K Q LE + + Q +++ +
Sbjct: 3076 KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSM 3135
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA------DFQKT 1253
K + +L + + VAEL+S ++ + + K HL + EA D
Sbjct: 3136 KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK-HLKELEAFRLEVKDKTDE 3194
Query: 1254 EHELRVQLSAFESKYEQL-----LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
H L L++ K +L + + EE +K + SL+++ Q + L
Sbjct: 3195 VHLLNDTLASEHKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ-RNLQLNL 3253
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
L E+ ++N+ + +IE +++ + L+++ ++M ++
Sbjct: 3254 LLEQQKQLLNESQ---QKIESQRMLYDAQLSEEQGRNLELQVLLQSQKVRIREM-SSTLD 3309
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
E +AQL+ S +E + EL QLE K S I + +E T
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPL------PSEDLLKELQKQLEEKHSRIVELLNE---TEK 3360
Query: 1429 QRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL-RLKMHENANHYETMQKESEIERVKL 1487
+ D + RQQ+ E ++++ T + E E + KMHE + E +Q++ E +R ++
Sbjct: 3361 YKLDSLQ-TRQQM-EKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418
Query: 1488 IE-ELNVKITESVSLNKQVAELNKALEEE 1515
+ +L + + + Q EL + + E
Sbjct: 3419 YKLDLEGQRLQGIMQEFQKQELEREEKRE 3447
Score = 65.7 bits (153), Expect = 1e-09
Identities = 130/687 (18%), Positives = 273/687 (39%), Gaps = 61/687 (8%)
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + +E I +T I + ++ + + ++E +++ + + + +
Sbjct: 65 MYINSSQRVESTVIPEST-IMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ NL L ++ + S + + + + L K EI LN+++ +
Sbjct: 124 VMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR 182
Query: 1037 VSY----MSMVSDYESKL-------AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
V+Y + + ++E+ + Q T L+ E ++ L+ + +++LQI
Sbjct: 183 VTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242
Query: 1086 RE--QDDQIKELKETKLTFEMNIPKTEGMIISSTIEP----MSDDANNVDXXXXXXXXXX 1139
++ + ++ + ++ K + + +E + D +
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+KV E E+ + + +E+ + T ++E TKII+ E EL + + +L
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
Query: 1200 KSKLEQLNTENDNL---LSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADF-QKT 1253
+ ++ Q N E N+ L+ + S + Q + EL K++ +Q E D Q+
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Query: 1254 EHELRVQLSAFESKYEQLLDS--VQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNL- 1309
E E + +L ++ +++ VQ + + ME++ T + ++++ N+
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEIKTRHKGEMENALRSYSNIT 482
Query: 1310 ----QEKYADV-INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQM 1362
Q K +V IN++ I + +K L E S+ +
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRG 542
Query: 1363 Q-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA-KVLELTHQLELKD----SEI 1416
Q +++ I E+ ++L ++ V+ +E+ K LEL H+ E+ + E+
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602
Query: 1417 YQKTHEYTITLTQRNDEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMHENAN-H 1472
+K + + E E R Q L +E+ + L + E E I K+ +N H
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKLKEDLEIEHRISIEKLKDNLGIH 662
Query: 1473 Y---------ETMQK--ESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEEVAKTN 1520
Y E QK + E+ LI + N I E L + Q + +N EE + N
Sbjct: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 722
Query: 1521 EMQTALE---NQEIEIVTLNDEITNLQ 1544
E+Q +E +E E TL E+ LQ
Sbjct: 723 ELQKEIEILRQEEKEKGTLEQEVQELQ 749
Score = 55.2 bits (127), Expect = 2e-06
Identities = 94/513 (18%), Positives = 208/513 (40%), Gaps = 37/513 (7%)
Query: 814 SEYTIQEDEL-VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
SE ++E + +N ++ L D ++ K L+ E E + + ++ + L ++L +
Sbjct: 2969 SESWLEERKAYINTISSLKD---LITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQV 3025
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK--------E 924
+++ A RT+L +T L LE ++ E+Q + K E
Sbjct: 3026 FLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLHKADRRSLLSE 3085
Query: 925 IEDLEIEFNTQIESAIRDK---KVLNEKYEKNIEY----VTQLEAQLQEYKNNIENLNMN 977
I+ L + N + + R++ K E E NI+ + +++ +L K+ L
Sbjct: 3086 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145
Query: 978 VEELNKMNLELIDKHVQKQQTQSPDYTEQY--INEINKLNALLKQKDEEIIALNQKINNA 1035
+ + EL + Q + Q+ + E+ +K K +E+ LN + +
Sbjct: 3146 LSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3205
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE- 1094
+ E + A+ E +EE++ + L KQ N +L +L+ +Q + E
Sbjct: 3206 HKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3265
Query: 1095 ---LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
++ ++ ++ + + +G + + S + ++Q +
Sbjct: 3266 QQKIESQRMLYDAQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERELHAQLQSSDGTG 3325
Query: 1152 QERSVLQEQS--AKLNTELQECYTKIIQL--ET----LNTELTGHDVVNQEQINQLKSKL 1203
Q R L + +L +L+E +++I++L ET L++ T + Q+++ +
Sbjct: 3326 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3385
Query: 1204 EQ-LNTENDNLLSTVAELRSSISSAVDQRGFEI--AELWKQHLAQREADFQKTEHELRVQ 1260
EQ NTE + + + ++++ ++ +L Q L +FQK E E +
Sbjct: 3386 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3445
Query: 1261 LSAFESKYEQLLD-SVQSSTQEETNKIVTMEQV 1292
+ Y+ L + + S T + T V +++
Sbjct: 3446 RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKI 3478
Score = 53.6 bits (123), Expect = 6e-06
Identities = 153/762 (20%), Positives = 329/762 (43%), Gaps = 89/762 (11%)
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKSVH 663
E+ E R I+ + S K DL+ ++ + Q+ EV D ++ ++ V
Sbjct: 2970 ESWLEERKAYINTISSLK-DLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVF 3026
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK 723
LEE+ L+A + EL L G + LE + I + Y Q M+ K
Sbjct: 3027 LEERSVLLAAFRTELTA------LGTTDAVGLLNCLE---QRIQEQGVEY-QAAMECLHK 3076
Query: 724 LEKMSA-EKISELLAKIN-------HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
++ S +I L A++N E++S+ +Q ++ IQ++ + ++ ELS K
Sbjct: 3077 ADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMK 3136
Query: 776 SRICRLEESIA----VMEDRRYSLERKADQLGSYLQEKQKAYSE---YTIQEDELVNRLA 828
R L+E ++ V+ + + L + +L + L+ + K E + ++ + + +
Sbjct: 3137 DRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVH 3196
Query: 829 VLMD-----HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQ---HYNALV 880
+L D H + E Q +E E +L + + EE ++L+ SL +Q N L+
Sbjct: 3197 LLNDTLASEHKKSRELQ-WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLL 3255
Query: 881 EKANR-----TDLAESESTKYQTQLRDLES-NLK-RITHEHQTLIVQKKKEIEDLEIEFN 933
E+ + ES+ Y QL + + NL+ ++ + Q + +++ D E E +
Sbjct: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERELH 3315
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
Q++S+ D + + + + +L+ QL+E + I L +N E K++ L +
Sbjct: 3316 AQLQSS--DGTGQSRPPLPSEDLLKELQKQLEEKHSRIVEL-LNETEKYKLD-SLQTRQQ 3371
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQF 1053
++ Q T Q E N + +++ L K+ + Q + + ++ +
Sbjct: 3372 MEKDRQVHRKTLQTEQEAN------TEGQKKMHELQSKVEDLQ----RQLEEKRQQVYKL 3421
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
+ + ++ MQ KQ L+ ++ E +IL + ++ T+ + +T +
Sbjct: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE--------PTTWSLTSDRTRNWV 3473
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
+ IE + ++N E E I+++ LQ ++KL L + +
Sbjct: 3474 LQQKIEGETKESNYAKLIEMNGGGTG----CNHELEMIRQK--LQCVASKLQV-LPQKAS 3526
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
+ +Q ET + E + QE I+++ +L++L + S V+ +S S ++
Sbjct: 3527 ERLQFETADDE---DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTERLLR 3582
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESK---YEQLLDSVQSSTQEETNKIVTME 1290
+ AEL H++Q + +++LR + E + Y Q +S++ N +E
Sbjct: 3583 QNAEL-TGHISQ----LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3637
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+ + + ++ ++E+ LQ+ ++ L++E+ ++ +
Sbjct: 3638 AIIASEKEVWNREK--LTLQKSLKRAEAEVYKLKAELRNDSL 3677
Score = 50.4 bits (115), Expect = 5e-05
Identities = 160/800 (20%), Positives = 325/800 (40%), Gaps = 81/800 (10%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-LLEAARFEISLEHSK 273
KQQ+ +Q + EK L+ + IS L++ + L+ + E++L+ ++
Sbjct: 664 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
L +E+E +Q ++ + KTE+ EK E N +L +K LE
Sbjct: 724 LQKEIE-----ILRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKEN--DLQEKFAQLEA 775
Query: 334 LNCQIRQTNKELENKL---ATMGTESKAV--SSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
N ++ K LE+ L + E + + S K + K + + Q
Sbjct: 776 ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 835
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY--VISEKDTXXXXXXXXXXGKD 446
LN++ +K+ N A+ + N + +EY ++ KD
Sbjct: 836 CIQ--LNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVN--------EIAKVQEQLKQEL--NDEIKDV 496
+ + L E P+ + + ++ D + E+ +V E+ EL N E+
Sbjct: 891 SKLKALNEELNLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMENLEVTKR 950
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAAN---KNMIKVKSNHKLKLKQMQKTIDN--FSKVS 551
+L ++L EQ+ Q + EI N K++ + K L+ ++++ I++ V
Sbjct: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAEDVQ 1010
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMI-----EM 605
+ + L + + ++ + AE K N +S M+E V ++ M +
Sbjct: 1011 SCDTQESSLLDGVVTMTSRGAEGSVSKVNKSF---GEESKIMVEDKVSFENMTVGEESKQ 1067
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVC-SEIKSVH 663
E L L +++ S + E LQ++ + ++ + D+ Q+++ ++C S + S H
Sbjct: 1068 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 664 LEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL-- 720
+++ + + K K L + E L +E+ ++ + + M K Q E L
Sbjct: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHL 1186
Query: 721 -TDKLEKMSAEKISELL----AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
KL+K +E+ S L + + ++ + + K D EN + EL Y+
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMD 832
+ +E++ + ++ K L + L + +Q + E+ L +
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
Query: 833 -HDRVVEKQLLEIEHENK--ELQKKNQILLEEN--------QNLQISLSDMQQHYNALVE 881
H ++ + +++ H++K LQ + LEE +LQ L + +Q+Y A +
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIH 1366
Query: 882 KANRTDLAESESTKYQTQLRD----LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-- 935
+ A SEST + D ES+ +R + + KK I D IEF+ +
Sbjct: 1367 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCV----KKNI-DGTIEFSGEFG 1421
Query: 936 IESAIRDKKVLNEKYEKNIE 955
++ K+L ++Y++ +E
Sbjct: 1422 VKEETNIVKLLEKQYQEQLE 1441
Score = 46.8 bits (106), Expect = 6e-04
Identities = 277/1464 (18%), Positives = 572/1464 (39%), Gaps = 161/1464 (10%)
Query: 159 SVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQM 218
S+L+ + K +E +L + +++++++I + + ED KQQ
Sbjct: 778 SILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQC 836
Query: 219 TKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQEL 278
++ E EKQR K+ ++ E + + + LE SK QEL
Sbjct: 837 IQLNEEI---------EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887
Query: 279 EQXXXXXXXXXXXXX-----XLAKQSIEPSCEEKT---------EIEEKGSLEIANMTEL 324
E K E+KT E+ EK + E+ E+
Sbjct: 888 EYKSKLKALNEELNLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMENLEV 947
Query: 325 TK--KIEL---LEHLNCQIRQTNKE---LENKLATMGTESKAVSSPSKKGSPLISRKSGR 376
TK K+EL L L+ Q++Q + E L ++ ++ E + VS ++ +I+
Sbjct: 948 TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH---- 1003
Query: 377 NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
N A ++S +Q SS D + E + +NK ++ ++ E
Sbjct: 1004 NRAEDVQSCDTQESSLL-----DGVVTMTSRGA-EGSVSKVNKSFGEESKIMVEDKVSFE 1057
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
G+++ QL L+H + S + T + +++ K LK E ND +
Sbjct: 1058 NMTV---GEESKQEQLILDHLPSVTKESSLRA-TQPSENDKLQKELNVLKSEQNDLRLQM 1113
Query: 497 NVKDLIEKLKSAEEQITQLNDEID-AANKNMIKVKSN----HKLKLKQMQKTIDNFSKVS 551
+ + L + + Q+ + ++ +K + +K + K+K++QK I +
Sbjct: 1114 EAQRICLSLVYSTH-VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQK-IHQLELQT 1171
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD------YDSGRMIESDVYKKMIEM 605
+E + LH L K+ + E+ + L + Y E + K
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
+ ++E + + D + +H L K E +KL + S + + LE
Sbjct: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI-MNKLQNYIQENMDLTDKL 724
+ L + E L I + + E + K + +D+ KL+ +QE L L
Sbjct: 1292 FGEENLPKEETEF-LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSL 1350
Query: 725 EKMSAEKISELLAKINHEEQSKIQ--TQFGIDAKIQERDLYIENIESELSKYKSRICRLE 782
++ E A+I H Q ++Q ++ + + + I +++ + Y C +
Sbjct: 1351 QQQLKETEQNYEAEI-HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CVKK 1408
Query: 783 ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
+E +S E + + ++ +K Y E Q +E V ++ V M + +L
Sbjct: 1409 NIDGTIE---FSGEFGVKEETNIVKLLEKQYQE---QLEEEVAKVIVSMSIAFAQQTELS 1462
Query: 843 EIE--HENKELQKKNQILLEENQNL--QISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
I EN K+ + ++ Q+ ++ LS Q + D+ E +++
Sbjct: 1463 RISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF----ETVDVKFKE--EFKP 1516
Query: 899 QLRDLESNLKRI--THEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
++L + K I ++ I + K + + E ++ ++ I + + +E +++
Sbjct: 1517 LSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDA 1576
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
QL ++ ++ + L +E + L H+++ + Q D EQ EI +LN
Sbjct: 1577 SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ-EQLQEEIKRLNR 1635
Query: 1017 LLKQK----DEEIIALNQKINNAQVSYMSMVS-----DYESKLAQFTTKLENMEE----- 1062
L Q+ +E +++ +++ ++ + +S +L +T+ +N E
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNETQGEG 1695
Query: 1063 EMQRVSKQLLDSKQHNEELQILVREQ------DDQIKELKETKLTFEMNIPKTEGMIISS 1116
E Q ++ LD K + +IL E+ ++++ ++ + + +T G +
Sbjct: 1696 EEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLG 1755
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
++ S ++ V EE + + S+ + + ++K+
Sbjct: 1756 ILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVT 1815
Query: 1177 QLET-LNTEL-------TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ T L+ L T D N+E + + S+L+ + LL ++E S + A
Sbjct: 1816 EEGTELSQRLVRSGFPGTEIDPENEELMLNISSRLQ---AAVEKLLEAISETSSQLEHAK 1872
Query: 1229 DQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT 1288
+ + E ++Q Q + K + ELR +L EQL +V+ S E
Sbjct: 1873 VTQTELMRESFRQ--KQEATESLKCQEELRERLHEESRAREQL--AVELSKAEGVIDGYA 1928
Query: 1289 MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE---IEDEKVAFXXXXXXXXXXX 1345
E+ T + ++Q+K + + L+++ N+++ L +E I++E+
Sbjct: 1929 DEK-TLFERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
Query: 1346 XXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
L E + K M+E+ + E + +D + +V L
Sbjct: 1988 GPVEQQLLQETE--KLMKEKLEVQCQAEKVR-------------------DDLQKQVKAL 2026
Query: 1406 THQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
+E + S + E +N E ++RQQ EK++E + + E AI R
Sbjct: 2027 EIDVEEQVSRFIELEQE-------KNTELMDLRQQNQALEKQLEKMR-KFLDEQAIDR-- 2076
Query: 1466 MHENANHYETMQK-ESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQT 1524
HE + +QK E +++ V + ++ T ++V +L L+E+ K +E+
Sbjct: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQT------REVEQLANHLKEKTDKCSELLL 2130
Query: 1525 ALENQEIEIVTLNDEITNLQNMVR 1548
+ E + +I N+EI L+ VR
Sbjct: 2131 SKEQLQRDIQERNEEIEKLEFRVR 2154
>L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein.
Length = 1300
Score = 93.1 bits (221), Expect = 8e-18
Identities = 230/1190 (19%), Positives = 489/1190 (41%), Gaps = 100/1190 (8%)
Query: 362 PSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDL 421
PSK+ L + + + K S +T N D+ + + + ++ + + +
Sbjct: 187 PSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLI-HATTYIPLMDNADSSPV 245
Query: 422 VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
VDK VI G L + E+ + L+ + T +E V
Sbjct: 246 VDKREVIDLLKPDQVEGIQKS-GTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV 304
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
+ LK++ + I+D K +L + Q+ + + + A ++ K K ++M
Sbjct: 305 VDLLKEK-SGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMM 363
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
+ + V K+ + E+ H++ Q + ++ Q+ + +E+++
Sbjct: 364 TEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQ-QMQMKFQQVREQMEAEIAHL 422
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKY----DEVEDKLADISQLQSDQVCS 657
E L + + LES++ EL+ L+Q Y +E+ +K + Q + + +
Sbjct: 423 KQENGILRDAVSNTTNQLESKQS---AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
E + L+ Q+ +E+ I + E +DL++ N++Q+ +
Sbjct: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ---QDLQSKFVAKENEVQSL---H 533
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
LTD L +S +++ + L ++ EQ ++ + + ++Q+ E +++++ ++ S+
Sbjct: 534 SKLTDTL--VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
I + S +V+ A++L + EK K + ED L + + DR+
Sbjct: 592 IAA-QTSASVL----------AEELHKVIAEKDKQIKQ---TEDSLAS------ERDRLT 631
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
K E E K++Q N +L E Q LQ +L++ Q +EK ++ + + +
Sbjct: 632 SK-----EEELKDIQNMNFLLKAEVQKLQ-ALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 898 TQLRDLESNLKRITHEHQTLIVQKK---KEIEDLEIEFNTQIESAIRDK--KVLNEKYEK 952
+ L+ + E + L Q K E++ L+ + Q + ++ K + EK EK
Sbjct: 686 EE--QLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 953 NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEI 1011
LE L + E LN E + + E+ D K Q Q E+ I
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
++ + +K +E + A K+ N + + V D + ++ ++ N++ +++ +
Sbjct: 804 HEKDGKIKSVEELLEAELLKVANKEKT----VQDLKQEIKALKEEIGNVQ--LEKAQQLS 857
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+ SK +ELQ L++ +++Q+ +K E ++ T + E S A+ +
Sbjct: 858 ITSKV--QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
+ +E E ++E+ + + +L L+E + + + T+L DV
Sbjct: 916 QHNLKEASSASQFEELEIVLKEK---ENELKRLEAMLKERESDL----SSKTQLL-QDVQ 967
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA--D 1249
++ ++ KS++EQL +N S+ + + +R EI+ LW + + ++A
Sbjct: 968 DENKL--FKSQIEQLKQQNYQQASSFPP-HEELLKVISEREKEISGLWNELDSLKDAVEH 1024
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD------KE 1303
+K +E + Q+ A E + +++L + +N + E + + K ++
Sbjct: 1025 QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN-LSYGEWLHGFEKKAKECMAGTSGS 1083
Query: 1304 EHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ 1363
E ++ L+ K + +L+ E E K + E +K
Sbjct: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS----VEQEENKWKVKV 1139
Query: 1364 EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH-QLELKDSEIYQKTH- 1421
++S I Q++ S D E E H ++EL+ +E+ + T+
Sbjct: 1140 DESHKTIK----QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYV 1195
Query: 1422 -EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
E Q N+ +R + E +K DL ++ + L +++ K+ + A T+ + S
Sbjct: 1196 TEVRELKAQLNETLTKLRTEQNERQKVAGDL-HKAQQSLELIQSKIVKAAGD-TTVIENS 1253
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELN---KALEEEVAKTNEMQTALE 1527
++ E + K T SVSLN+ V +L +A+ +++ K E LE
Sbjct: 1254 DVSPET---ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
Score = 85.4 bits (202), Expect = 2e-15
Identities = 169/892 (18%), Positives = 388/892 (43%), Gaps = 73/892 (8%)
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAV-SSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
+ + + +Q +++E ++A + E+ + + S + L S++S +K++ +++L
Sbjct: 402 QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE--LNKLRQDYARLV 459
Query: 391 SET------LNQDTDKKINKNEIA-KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+E L Q+ +K N + A +L++ +Q + + + I ++
Sbjct: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K +A+ H + + V + + ++ + K+ +E + V+D++E
Sbjct: 520 SK--FVAKENEVQSLHSKLTDTL-VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE 576
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVRL 560
+ ++ + QI Q + +I A + + HK+ K KQ+++T D+ + D +
Sbjct: 577 QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD---RLTSK 633
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI-SLL 619
EEL + L+ E LQ L + + E +KM + + + +++ + L
Sbjct: 634 EEELKDIQNMNFLLKAEVQKLQA-LANEQAAAAHE---LEKMQQSVYVKDDKIRLLEEQL 689
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + ++E IL + ++ ++ + L S+Q ++ EQ++ K E
Sbjct: 690 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-----VEQMEKCIQEKDEKL 744
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+E L L+ G I+ KE+ +N ++ EN LT +++ + A++ ++
Sbjct: 745 KTVEEL-LET----GLIQ--VATKEEELNAIRT---ENSSLTKEVQDLKAKQNDQVSFAS 794
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
EE K+ I E+D I+++E L ++ E+++ +D + ++
Sbjct: 795 LVEELKKV---------IHEKDGKIKSVEELLEAELLKVANKEKTV---QDLKQEIKALK 842
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
+++G+ EK + S T + EL N L + ++ L E E + K Q L
Sbjct: 843 EEIGNVQLEKAQQLS-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
EEN++L+ + ++ QH A++ + E + + +L+ LE+ LK E ++ +
Sbjct: 902 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK----ERESDLS 957
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEK-------YEKNIEYVTQLEAQLQEYKNNIE 972
K + ++D++ E N +S I K N + +E+ ++ +++ E ++ N ++
Sbjct: 958 SKTQLLQDVQDE-NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 1016
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+L VE K N E + V+ + ++ + ++ +++ + L + K
Sbjct: 1017 SLKDAVEHQRKKNNER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKE 1075
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
A S V E KL + ++ E ++ L +++ ++LQ V +++++
Sbjct: 1076 CMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKW 1135
Query: 1093 K-ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
K ++ E+ T I + + SS E + N D +++++ E
Sbjct: 1136 KVKVDESHKT----IKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAE--- 1188
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
ERS + +L +L E TK+ + ++ G Q+ + ++SK+
Sbjct: 1189 MERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI 1240
Score = 84.6 bits (200), Expect = 3e-15
Identities = 218/1194 (18%), Positives = 491/1194 (41%), Gaps = 109/1194 (9%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN- 532
D + K + + K+ N + + + + + K ++ + +D++ N+++ S+
Sbjct: 53 DKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE-DDQVAPVPLNVVETSSSV 111
Query: 533 -HKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
+ K ++ QK + + K SD++K + E + Q E +
Sbjct: 112 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 171
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQ 649
+G SD K +E + R +A+ L + K + K + E+ D
Sbjct: 172 NG----SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPL 227
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-DLENDKEDIMN 708
+ + + + +D K+E+ +++ +++ Q GT K E DKE+
Sbjct: 228 IHATTYIPLMDNADSSPVVD-----KREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 282
Query: 709 KLQNYI----------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K ++++ E + + D L++ S I + L K + E + + Q +Q
Sbjct: 283 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGV-IQDALKKSSKGELTTLIHQ------LQ 335
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYT 817
E+D + ++ + + K R +L + + ++R + R D++G+ +E ++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-----NQILLEENQNLQISLSDM 872
+ E +E ++ ++ EN L+ NQ+ +++ L D
Sbjct: 396 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 455
Query: 873 QQHYNALVEKANRTDLAESESTKYQ---TQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ N L EK + E + + TQL+ +R E Q+ I ++ E E +
Sbjct: 456 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 515
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIENLNMNVEELN 982
+ ++ + + + L+ K + QLE +L Q+ N E+L M V+++
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ N E + +Q+ +Q T + +L+ ++ +KD++I + + + S
Sbjct: 576 EQN-EALKAQIQQFHSQIAAQTSASVLA-EELHKVIAEKDKQIKQTEDSLASERDRLTSK 633
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ + + L+ +++Q ++ + + E++Q V +DD+I+ L+E +L
Sbjct: 634 EEELKD-IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE-QLQH 691
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE-RSVLQEQS 1161
E++ E I++ + + + + + Q ++ +++ +QE+
Sbjct: 692 EISNKMEEFKILNDQNKALKSEVQKLQTL----------VSEQPNKDVVEQMEKCIQEKD 741
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
KL T + T +IQ+ T EL N +++ L+ + + S V EL+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD-LKAKQNDQVSFASLVEELK 800
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES--------KYEQLLD 1273
I D + + EL + L + A+ +KT +L+ ++ A + K +QL
Sbjct: 801 KVIHEK-DGKIKSVEELLEAELL-KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL-- 856
Query: 1274 SVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED--- 1329
S+ S QE N + E Q+ +++ L++KE+ L N + D+ + E L++ +++
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 916
Query: 1330 ---EKVAFXXXXXXXXXXXXXXXXDLR------TENQSYKQMQEQSILNINEENAQLKKS 1380
++ + +L+ E +S + Q + ++ +EN +L KS
Sbjct: 917 HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN-KLFKS 975
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
++L++ + E + S ++ + + + + N RQQ
Sbjct: 976 QIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK-NNERQQ 1034
Query: 1441 LVE-YEKRIEDLTYEKESELAI-LRLKMHENANHYETMQKE-----SEIERVKLIEELNV 1493
VE E +++ + ++++ L E + +E KE S E VK++E
Sbjct: 1035 QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLK 1094
Query: 1494 KITESVSLNKQVAELNKA-LEEEVAKTNEMQTALENQE----IEIVTLNDEITNLQNMVR 1548
+ E +L + E K+ L E ++Q ++E +E +++ + I +Q+
Sbjct: 1095 EADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFT 1154
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRDVR 1602
+S ++++ S D + R E+ M E +AE++ + Y+ R+++
Sbjct: 1155 SSEQELERLRSENKDIENLRREREHLEMELE------KAEMERSTYVTEVRELK 1202
Score = 76.6 bits (180), Expect = 7e-13
Identities = 197/1009 (19%), Positives = 415/1009 (41%), Gaps = 98/1009 (9%)
Query: 142 GDVTHLSNTIKEKDNALSVLQVKMKIMETTILDL-QEKINEKDQ----IIEAKNKATTXX 196
G++T L + ++EKD L+ ++ + L QE + EK++ I K++ T
Sbjct: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQR--LLKDIESKDVRISSLE 254
E T+Q K Q+ MEAE KQ +L+D S + LE
Sbjct: 385 KEHNVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT--NQLE 441
Query: 255 EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
A ++ ++++L EL + L ++ ++ E+ + K
Sbjct: 442 SKQS---AELNKLRQDYARLVNELTEKTGK----------LQQEEVQKKNAEQAATQLKV 488
Query: 315 SLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKS 374
L+ A + + + ++L++K + E++ S SK L+S++
Sbjct: 489 QLQEAER-RWEEVQSYIRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQ 545
Query: 375 -GRNTASKMKSPWSQLSSE-TLNQDTDKKINKNEIAKLEM------VIQSLNKDLVDKEY 426
+ M+S +++ E +L + +NE K ++ + + ++ +E
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
Query: 427 --VISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ 484
VI+EKD + + + E + ++ + + + + + +A Q
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKE-EELKDIQNMNFL-LKAEVQKLQALANEQAA 663
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI 544
EL + V VKD +K++ EEQ L EI + + +K ++QK
Sbjct: 664 AAHELEKMQQSVYVKD--DKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQ 718
Query: 545 DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
S+ NK++V E+ + +K +L+ + L+ L+ ++ + I
Sbjct: 719 TLVSE--QPNKDVVEQMEKC--IQEKDEKLKTVEELLETGLI-----QVATKEEELNAIR 769
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
EN + T K + L++++ D V ++++ + +K I ++ +K +
Sbjct: 770 TENSSLT--KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK 827
Query: 665 EEQIDALSASKKELALVIENLKLDKEQ---LYGTIKDLEN---DKEDIMNKLQNYIQENM 718
E+ + L K L I N++L+K Q + +++L+N KE+ MN ++ ++E
Sbjct: 828 EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK- 886
Query: 719 DLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
+ + + K + L + N ++ +Q + K E +E L + ++ +
Sbjct: 887 ----EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 942
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
RLE A++++R L K L E + S+ + + + + H+
Sbjct: 943 KRLE---AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE---- 995
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+LL++ E +K+ L E +L+ ++ ++ N ++ +L E K
Sbjct: 996 -ELLKVISER---EKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLF 1051
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ SNL H +KK + E T S + KVL K ++ E T
Sbjct: 1052 PKVSVPSNLSYGEWLHG---FEKKAK----ECMAGT---SGSEEVKVLEHKLKEADEMHT 1101
Query: 959 QLEAQLQEYKNNI-------ENLNMNVE-ELNKMNLELIDKHVQKQQTQSP-DYTEQYIN 1009
L+ + ++YK+ + + L +VE E NK +++ + H +Q QS +EQ +
Sbjct: 1102 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1161
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ N ++ E L ++ A++ +Y++ V + +++L + TKL + E Q+
Sbjct: 1162 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQK 1221
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
V+ L ++Q E +Q + + ++ + ++ E + E M +S
Sbjct: 1222 VAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 1270
Score = 66.9 bits (156), Expect = 6e-10
Identities = 150/812 (18%), Positives = 331/812 (40%), Gaps = 43/812 (5%)
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
R ++ I D++ + ++K + ++ SE ++ +L + LAV D V
Sbjct: 43 REQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL 102
Query: 840 QLLEIE---HENKELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTK 895
++E E K+ +KK + +LEE + S + + + T +E+ ++K
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + ++ + +TL+V K++ E L + T+ ES KK ++K +
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQ-EALPLHQETKQESGSGKKKASSKKQKTENV 221
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+V + Y ++N + + + ++L+ K Q + Q T++ E +K N
Sbjct: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL-KPDQVEGIQKSG-TKKLKTETDKEN 279
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A +K KD + + + + + +S + Q K ++ + E+ + QL
Sbjct: 280 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQL---- 334
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L V+E K+ + +LT EM K ++ + ++
Sbjct: 335 QEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNT-ELTGHDV 1190
Q + +F Q R ++ + A L E L++ + QLE+ + EL
Sbjct: 394 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ 453
Query: 1191 VNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+N+L K L+Q + N +L+ + A ++R E+ ++ A+ E
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA-ERRWEEVQSYIRKRTAEHE 512
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
A Q + + + + +S + +L D++ S Q E + ME NK + + ++
Sbjct: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM----- 1362
++ E+ + QI+ S+I + A +TE+ +
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+E+ + +I N LK ++ E ++ + +KD +I +
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQ 688
Query: 1423 YTITLTQRNDEFENVRQQ---LVEYEKRIEDLTYEKESELAILRLK--MHENANHYETMQ 1477
++ + +EF+ + Q L ++++ L E+ ++ + +++ + E +T++
Sbjct: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
Query: 1478 KESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
+ E +++ EELN TE+ SL K+V +L ++V+ + +E + I
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS----FASLVEELKKVIH 804
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
+ +I +++ ++ A K+ D KQ
Sbjct: 805 EKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
>D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein.
Length = 1307
Score = 93.1 bits (221), Expect = 8e-18
Identities = 230/1190 (19%), Positives = 489/1190 (41%), Gaps = 100/1190 (8%)
Query: 362 PSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDL 421
PSK+ L + + + K S +T N D+ + + + ++ + + +
Sbjct: 194 PSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLI-HATTYIPLMDNADSSPV 252
Query: 422 VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
VDK VI G L + E+ + L+ + T +E V
Sbjct: 253 VDKREVIDLLKPDQVEGIQKS-GTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV 311
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
+ LK++ + I+D K +L + Q+ + + + A ++ K K ++M
Sbjct: 312 VDLLKEK-SGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMM 370
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
+ + V K+ + E+ H++ Q + ++ Q+ + +E+++
Sbjct: 371 TEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQ-QMQMKFQQVREQMEAEIAHL 429
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKY----DEVEDKLADISQLQSDQVCS 657
E L + + LES++ EL+ L+Q Y +E+ +K + Q + + +
Sbjct: 430 KQENGILRDAVSNTTNQLESKQS---AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 486
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
E + L+ Q+ +E+ I + E +DL++ N++Q+ +
Sbjct: 487 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ---QDLQSKFVAKENEVQSL---H 540
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
LTD L +S +++ + L ++ EQ ++ + + ++Q+ E +++++ ++ S+
Sbjct: 541 SKLTDTL--VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQ 598
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
I + S +V+ A++L + EK K + ED L + + DR+
Sbjct: 599 IAA-QTSASVL----------AEELHKVIAEKDKQIKQ---TEDSLAS------ERDRLT 638
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
K E E K++Q N +L E Q LQ +L++ Q +EK ++ + + +
Sbjct: 639 SK-----EEELKDIQNMNFLLKAEVQKLQ-ALANEQAAAAHELEKMQQSVYVKDDKIRLL 692
Query: 898 TQLRDLESNLKRITHEHQTLIVQKK---KEIEDLEIEFNTQIESAIRDK--KVLNEKYEK 952
+ L+ + E + L Q K E++ L+ + Q + ++ K + EK EK
Sbjct: 693 EE--QLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 750
Query: 953 NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYINEI 1011
LE L + E LN E + + E+ D K Q Q E+ I
Sbjct: 751 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 810
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
++ + +K +E + A K+ N + + V D + ++ ++ N++ +++ +
Sbjct: 811 HEKDGKIKSVEELLEAELLKVANKEKT----VQDLKQEIKALKEEIGNVQ--LEKAQQLS 864
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXX 1131
+ SK +ELQ L++ +++Q+ +K E ++ T + E S A+ +
Sbjct: 865 ITSKV--QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 922
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
+ +E E ++E+ + + +L L+E + + + T+L DV
Sbjct: 923 QHNLKEASSASQFEELEIVLKEK---ENELKRLEAMLKERESDL----SSKTQLL-QDVQ 974
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA--D 1249
++ ++ KS++EQL +N S+ + + +R EI+ LW + + ++A
Sbjct: 975 DENKL--FKSQIEQLKQQNYQQASSFPP-HEELLKVISEREKEISGLWNELDSLKDAVEH 1031
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD------KE 1303
+K +E + Q+ A E + +++L + +N + E + + K ++
Sbjct: 1032 QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN-LSYGEWLHGFEKKAKECMAGTSGS 1090
Query: 1304 EHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ 1363
E ++ L+ K + +L+ E E K + E +K
Sbjct: 1091 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS----VEQEENKWKVKV 1146
Query: 1364 EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH-QLELKDSEIYQKTH- 1421
++S I Q++ S D E E H ++EL+ +E+ + T+
Sbjct: 1147 DESHKTIK----QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYV 1202
Query: 1422 -EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
E Q N+ +R + E +K DL ++ + L +++ K+ + A T+ + S
Sbjct: 1203 TEVRELKAQLNETLTKLRTEQNERQKVAGDL-HKAQQSLELIQSKIVKAAGD-TTVIENS 1260
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELN---KALEEEVAKTNEMQTALE 1527
++ E + K T SVSLN+ V +L +A+ +++ K E LE
Sbjct: 1261 DVSPET---ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1307
Score = 85.4 bits (202), Expect = 2e-15
Identities = 169/892 (18%), Positives = 388/892 (43%), Gaps = 73/892 (8%)
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAV-SSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
+ + + +Q +++E ++A + E+ + + S + L S++S +K++ +++L
Sbjct: 409 QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE--LNKLRQDYARLV 466
Query: 391 SET------LNQDTDKKINKNEIA-KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+E L Q+ +K N + A +L++ +Q + + + I ++
Sbjct: 467 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 526
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE 503
K +A+ H + + V + + ++ + K+ +E + V+D++E
Sbjct: 527 SK--FVAKENEVQSLHSKLTDTL-VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE 583
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KLKQMQKTIDNFSKVSDSNKEIVRL 560
+ ++ + QI Q + +I A + + HK+ K KQ+++T D+ + D +
Sbjct: 584 QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD---RLTSK 640
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI-SLL 619
EEL + L+ E LQ L + + E +KM + + + +++ + L
Sbjct: 641 EEELKDIQNMNFLLKAEVQKLQA-LANEQAAAAHE---LEKMQQSVYVKDDKIRLLEEQL 696
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + ++E IL + ++ ++ + L S+Q ++ EQ++ K E
Sbjct: 697 QHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-----VEQMEKCIQEKDEKL 751
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+E L L+ G I+ KE+ +N ++ EN LT +++ + A++ ++
Sbjct: 752 KTVEEL-LET----GLIQ--VATKEEELNAIRT---ENSSLTKEVQDLKAKQNDQVSFAS 801
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
EE K+ I E+D I+++E L ++ E+++ +D + ++
Sbjct: 802 LVEELKKV---------IHEKDGKIKSVEELLEAELLKVANKEKTV---QDLKQEIKALK 849
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILL 859
+++G+ EK + S T + EL N L + ++ L E E + K Q L
Sbjct: 850 EEIGNVQLEKAQQLS-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 908
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
EEN++L+ + ++ QH A++ + E + + +L+ LE+ LK E ++ +
Sbjct: 909 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK----ERESDLS 964
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEK-------YEKNIEYVTQLEAQLQEYKNNIE 972
K + ++D++ E N +S I K N + +E+ ++ +++ E ++ N ++
Sbjct: 965 SKTQLLQDVQDE-NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 1023
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+L VE K N E + V+ + ++ + ++ +++ + L + K
Sbjct: 1024 SLKDAVEHQRKKNNER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKE 1082
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
A S V E KL + ++ E ++ L +++ ++LQ V +++++
Sbjct: 1083 CMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKW 1142
Query: 1093 K-ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
K ++ E+ T I + + SS E + N D +++++ E
Sbjct: 1143 KVKVDESHKT----IKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAE--- 1195
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
ERS + +L +L E TK+ + ++ G Q+ + ++SK+
Sbjct: 1196 MERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI 1247
Score = 84.6 bits (200), Expect = 3e-15
Identities = 218/1194 (18%), Positives = 491/1194 (41%), Gaps = 109/1194 (9%)
Query: 474 DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN- 532
D + K + + K+ N + + + + + K ++ + +D++ N+++ S+
Sbjct: 60 DKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE-DDQVAPVPLNVVETSSSV 118
Query: 533 -HKLKLKQMQKTI--DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
+ K ++ QK + + K SD++K + E + Q E +
Sbjct: 119 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 178
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQ 649
+G SD K +E + R +A+ L + K + K + E+ D
Sbjct: 179 NG----SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPL 234
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK-DLENDKEDIMN 708
+ + + + +D K+E+ +++ +++ Q GT K E DKE+
Sbjct: 235 IHATTYIPLMDNADSSPVVD-----KREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 289
Query: 709 KLQNYI----------QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
K ++++ E + + D L++ S I + L K + E + + Q +Q
Sbjct: 290 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGV-IQDALKKSSKGELTTLIHQ------LQ 342
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYT 817
E+D + ++ + + K R +L + + ++R + R D++G+ +E ++
Sbjct: 343 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 402
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK-----NQILLEENQNLQISLSDM 872
+ E +E ++ ++ EN L+ NQ+ +++ L D
Sbjct: 403 VSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDY 462
Query: 873 QQHYNALVEKANRTDLAESESTKYQ---TQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ N L EK + E + + TQL+ +R E Q+ I ++ E E +
Sbjct: 463 ARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ 522
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIENLNMNVEELN 982
+ ++ + + + L+ K + QLE +L Q+ N E+L M V+++
Sbjct: 523 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 582
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
+ N E + +Q+ +Q T + +L+ ++ +KD++I + + + S
Sbjct: 583 EQN-EALKAQIQQFHSQIAAQTSASVLA-EELHKVIAEKDKQIKQTEDSLASERDRLTSK 640
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+ + + L+ +++Q ++ + + E++Q V +DD+I+ L+E +L
Sbjct: 641 EEELKD-IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE-QLQH 698
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE-RSVLQEQS 1161
E++ E I++ + + + + + Q ++ +++ +QE+
Sbjct: 699 EISNKMEEFKILNDQNKALKSEVQKLQTL----------VSEQPNKDVVEQMEKCIQEKD 748
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
KL T + T +IQ+ T EL N +++ L+ + + S V EL+
Sbjct: 749 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD-LKAKQNDQVSFASLVEELK 807
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES--------KYEQLLD 1273
I D + + EL + L + A+ +KT +L+ ++ A + K +QL
Sbjct: 808 KVIHEK-DGKIKSVEELLEAELL-KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL-- 863
Query: 1274 SVQSSTQEETNKIVTME-QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED--- 1329
S+ S QE N + E Q+ +++ L++KE+ L N + D+ + E L++ +++
Sbjct: 864 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 923
Query: 1330 ---EKVAFXXXXXXXXXXXXXXXXDLR------TENQSYKQMQEQSILNINEENAQLKKS 1380
++ + +L+ E +S + Q + ++ +EN +L KS
Sbjct: 924 HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN-KLFKS 982
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
++L++ + E + S ++ + + + + N RQQ
Sbjct: 983 QIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK-NNERQQ 1041
Query: 1441 LVE-YEKRIEDLTYEKESELAI-LRLKMHENANHYETMQKE-----SEIERVKLIEELNV 1493
VE E +++ + ++++ L E + +E KE S E VK++E
Sbjct: 1042 QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLK 1101
Query: 1494 KITESVSLNKQVAELNKA-LEEEVAKTNEMQTALENQE----IEIVTLNDEITNLQNMVR 1548
+ E +L + E K+ L E ++Q ++E +E +++ + I +Q+
Sbjct: 1102 EADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFT 1161
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRDVR 1602
+S ++++ S D + R E+ M E +AE++ + Y+ R+++
Sbjct: 1162 SSEQELERLRSENKDIENLRREREHLEMELE------KAEMERSTYVTEVRELK 1209
Score = 76.6 bits (180), Expect = 7e-13
Identities = 197/1009 (19%), Positives = 415/1009 (41%), Gaps = 98/1009 (9%)
Query: 142 GDVTHLSNTIKEKDNALSVLQVKMKIMETTILDL-QEKINEKDQ----IIEAKNKATTXX 196
G++T L + ++EKD L+ ++ + L QE + EK++ I K++ T
Sbjct: 332 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 391
Query: 197 XXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQR--LLKDIESKDVRISSLE 254
E T+Q K Q+ MEAE KQ +L+D S + LE
Sbjct: 392 KEHNVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT--NQLE 448
Query: 255 EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG 314
A ++ ++++L EL + L ++ ++ E+ + K
Sbjct: 449 SKQS---AELNKLRQDYARLVNELTEKTGK----------LQQEEVQKKNAEQAATQLKV 495
Query: 315 SLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKS 374
L+ A + + + ++L++K + E++ S SK L+S++
Sbjct: 496 QLQEAER-RWEEVQSYIRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQ 552
Query: 375 -GRNTASKMKSPWSQLSSE-TLNQDTDKKINKNEIAKLEM------VIQSLNKDLVDKEY 426
+ M+S +++ E +L + +NE K ++ + + ++ +E
Sbjct: 553 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 612
Query: 427 --VISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQ 484
VI+EKD + + + E + ++ + + + + + +A Q
Sbjct: 613 HKVIAEKDKQIKQTEDSLASERDRLTSKE-EELKDIQNMNFL-LKAEVQKLQALANEQAA 670
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTI 544
EL + V VKD +K++ EEQ L EI + + +K ++QK
Sbjct: 671 AAHELEKMQQSVYVKD--DKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQ 725
Query: 545 DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
S+ NK++V E+ + +K +L+ + L+ L+ ++ + I
Sbjct: 726 TLVSE--QPNKDVVEQMEKC--IQEKDEKLKTVEELLETGLI-----QVATKEEELNAIR 776
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
EN + T K + L++++ D V ++++ + +K I ++ +K +
Sbjct: 777 TENSSLT--KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK 834
Query: 665 EEQIDALSASKKELALVIENLKLDKEQ---LYGTIKDLEN---DKEDIMNKLQNYIQENM 718
E+ + L K L I N++L+K Q + +++L+N KE+ MN ++ ++E
Sbjct: 835 EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK- 893
Query: 719 DLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
+ + + K + L + N ++ +Q + K E +E L + ++ +
Sbjct: 894 ----EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 949
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
RLE A++++R L K L E + S+ + + + + H+
Sbjct: 950 KRLE---AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE---- 1002
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+LL++ E +K+ L E +L+ ++ ++ N ++ +L E K
Sbjct: 1003 -ELLKVISER---EKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLF 1058
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
+ SNL H +KK + E T S + KVL K ++ E T
Sbjct: 1059 PKVSVPSNLSYGEWLHG---FEKKAK----ECMAGT---SGSEEVKVLEHKLKEADEMHT 1108
Query: 959 QLEAQLQEYKNNI-------ENLNMNVE-ELNKMNLELIDKHVQKQQTQSP-DYTEQYIN 1009
L+ + ++YK+ + + L +VE E NK +++ + H +Q QS +EQ +
Sbjct: 1109 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1168
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ N ++ E L ++ A++ +Y++ V + +++L + TKL + E Q+
Sbjct: 1169 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQK 1228
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
V+ L ++Q E +Q + + ++ + ++ E + E M +S
Sbjct: 1229 VAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 1277
Score = 66.9 bits (156), Expect = 6e-10
Identities = 150/812 (18%), Positives = 331/812 (40%), Gaps = 43/812 (5%)
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
R ++ I D++ + ++K + ++ SE ++ +L + LAV D V
Sbjct: 50 REQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL 109
Query: 840 QLLEIE---HENKELQKKNQILLEENQNLQISLSDMQ-QHYNALVEKANRTDLAESESTK 895
++E E K+ +KK + +LEE + S + + + T +E+ ++K
Sbjct: 110 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 169
Query: 896 YQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ + ++ + +TL+V K++ E L + T+ ES KK ++K +
Sbjct: 170 KKPGQKKSKNGSDDQDKKVETLMVPSKRQ-EALPLHQETKQESGSGKKKASSKKQKTENV 228
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+V + Y ++N + + + ++L+ K Q + Q T++ E +K N
Sbjct: 229 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL-KPDQVEGIQKSG-TKKLKTETDKEN 286
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A +K KD + + + + + +S + Q K ++ + E+ + QL
Sbjct: 287 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQL---- 341
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L V+E K+ + +LT EM K ++ + ++
Sbjct: 342 QEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 400
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKII-QLETLNT-ELTGHDV 1190
Q + +F Q R ++ + A L E L++ + QLE+ + EL
Sbjct: 401 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQ 460
Query: 1191 VNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
+N+L K L+Q + N +L+ + A ++R E+ ++ A+ E
Sbjct: 461 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA-ERRWEEVQSYIRKRTAEHE 519
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
A Q + + + + +S + +L D++ S Q E + ME NK + + ++
Sbjct: 520 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 579
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM----- 1362
++ E+ + QI+ S+I + A +TE+ +
Sbjct: 580 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 639
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
+E+ + +I N LK ++ E ++ + +KD +I +
Sbjct: 640 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLEEQ 695
Query: 1423 YTITLTQRNDEFENVRQQ---LVEYEKRIEDLTYEKESELAILRLK--MHENANHYETMQ 1477
++ + +EF+ + Q L ++++ L E+ ++ + +++ + E +T++
Sbjct: 696 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 755
Query: 1478 KESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
+ E +++ EELN TE+ SL K+V +L ++V+ + +E + I
Sbjct: 756 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS----FASLVEELKKVIH 811
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
+ +I +++ ++ A K+ D KQ
Sbjct: 812 EKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 843
>BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein.
Length = 1006
Score = 93.1 bits (221), Expect = 8e-18
Identities = 189/991 (19%), Positives = 414/991 (41%), Gaps = 90/991 (9%)
Query: 322 TELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASK 381
TEL K I+ LE + + + ENK+ + E A+ + L K A +
Sbjct: 20 TELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVAR---LTKEKKALQEAHQ 76
Query: 382 MKSPWSQLSSETLNQDTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
Q + ++ T K+ + ++ LE ++ K +D E +++
Sbjct: 77 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTER--AKRKLEGDLKLT 134
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEI-AKVQEQLKQ------ELNDEI 493
D + QLE + + L + ED + A++Q+++K+ EL +E+
Sbjct: 135 QESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEEL 194
Query: 494 K-DVNVKDLIEKLKSAE----EQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS 548
+ + + +EK ++ E++++ +E A+ + + +L ++++ ++ +
Sbjct: 195 EAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAA 254
Query: 549 KVSDSNKEIVR---------LTEELHHLSQKVAELEEEKGNLQLHLVDYDSG----RMIE 595
++ +R L E++ L + +LE+EK L++ + D + +
Sbjct: 255 LRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAK 314
Query: 596 SDVYKKMIEMEN-LAETRLKAISLLESQKFDLVQELHILQQKYDEV----EDKLADISQL 650
+ K E+ L+E ++K + L+ Q D + LQ + E+ E+K ISQL
Sbjct: 315 ASAEKLCRTYEDQLSEAKIK-VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL 373
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL 710
+ + L Q++ S +K LA ++ L+ D + L ++ ++ + +L
Sbjct: 374 SRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLL----REQHEEEAEAQAEL 429
Query: 711 QNYIQE-NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE- 768
Q + + N ++ K A+ I EE + + + + + E + N +
Sbjct: 430 QRLLSKANAEVAQWRSKYEADAIQRT------EELEEAKKKLALRLQEAEEGVEAANAKC 483
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
S L K K R+ E + + +R S D+ +L+ +A E QE+E+ L
Sbjct: 484 SSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE---RALEERRRQEEEMQRELE 540
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN---ALVEKANR 885
R + +L + H ++E + + L EN+NLQ +SD+ + +++ +
Sbjct: 541 AAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEK 600
Query: 886 TDLA-ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
T A E E ++ Q L + E L+ E +TL +Q E+ ++ E + ++ +
Sbjct: 601 TKKALEGEKSEIQAALEEAEGALE--LEETKTLRIQ--LELSQVKAEVDRKLAEKDEECA 656
Query: 945 VLNEKYEKNIEYV-TQLEAQLQEYKNNIENLNMNVE-ELNKMNLELIDKHVQKQQTQSPD 1002
L +++ +E + L+A+ + +N L +E +LN + L+L H +Q T++
Sbjct: 657 NLRRNHQRAVESLQASLDAETRA-RNEALRLKKKMEGDLNDLELQL--GHATRQATEAQA 713
Query: 1003 YTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
T ++ + A +DEE L +++ + S ++L + LE E
Sbjct: 714 ATRLMQAQLKEEQA---GRDEE-QRLAAELHEQAQALERRASLLAAELEELRAALEQGER 769
Query: 1063 EMQRVSKQLLDSKQ-----HNEELQIL---------VREQDDQIKELKETKLTFEMNIPK 1108
+ ++LL++ + H++ +L + + +++E + + E K
Sbjct: 770 SRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKK 829
Query: 1109 --TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT 1166
T+ +++ ++ D + +++ L+ + EE ++Q KL
Sbjct: 830 AITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEA 889
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISS 1226
+++E ++ + + E ++ ++ +L + E+ + V +L+S + S
Sbjct: 890 KVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKS 949
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHEL 1257
+R FE AE Q A ++K +HEL
Sbjct: 950 Y--KRQFEEAE---QQANTNLAKYRKAQHEL 975
Score = 91.5 bits (217), Expect = 2e-17
Identities = 178/949 (18%), Positives = 393/949 (41%), Gaps = 83/949 (8%)
Query: 216 QQMTKMQENFIAMEAEWK---DEKQRLLKDIESKDVRISSLEEANKLLE--AARFEISLE 270
++M + E+ + E K + Q+ L D+++++ R+S+L +A LE E SLE
Sbjct: 52 EEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLE 111
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K +L L ++S+ + ++K ++EEK + + +++L+ ++E
Sbjct: 112 QEK---KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVED 168
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
+ L Q+++ KEL+ + + E +A + + R ++ +
Sbjct: 169 EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEK--QRAEAARELEELSERLEEAG 226
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTL-I 449
+ Q + + E+ +L ++ L + V + + D+L
Sbjct: 227 GASAGQREGCRKREAELGRLRRELE--EAALRHEATVAALRRKQAEGAAELGEQVDSLQR 284
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD--VNVKDLIEKLKS 507
+ +LE ++ + + N E + E+L + D++ + + V++L +L
Sbjct: 285 VRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 344
Query: 508 AEEQ----------ITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
A Q +++L +E + + + K+ L+++++ ++ SK + +
Sbjct: 345 ASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSA---L 401
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE------MENLAET 611
+ L H + E EE+ Q L S E ++ E E L E
Sbjct: 402 AHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA 461
Query: 612 RLK-AISLLESQ--------KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSV 662
+ K A+ L E++ K +++ + Q E ED ++ + S + K
Sbjct: 462 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQ--TESEDVTLELERATSAAAALDKKQR 519
Query: 663 HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN----- 717
HLE ++ ++E+ +E + + L + L + E+ + L+ +EN
Sbjct: 520 HLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQE 579
Query: 718 --MDLTDKLEKMSAEKISEL--LAKINHEEQSKIQTQF-GIDAKIQERDLYIENIESELS 772
DLTD++ +S + I EL K E+S+IQ + ++ + I+ ELS
Sbjct: 580 EISDLTDQV-SLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELS 638
Query: 773 KYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL---VNRLA 828
+ K+ + R L E + R + +R + L + L + +A +E + ++ +N L
Sbjct: 639 QVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE 698
Query: 829 VLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSD----MQQHYNALVE 881
+ + H +Q E + + +Q K+ Q +E Q L L + +++ + L
Sbjct: 699 LQLGH---ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAA 755
Query: 882 KAN--RTDLAESESTKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
+ R L + E ++ + LE+ + + H T ++ +KK++E + + ++E
Sbjct: 756 ELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEE 815
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
A ++++ EK +K I + +L++ ++ +L + L + EL + + +Q
Sbjct: 816 AAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQA 875
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+Q + KL A +++ + E+ A +K A + V +E ++ + + E
Sbjct: 876 ALRGGKKQ----VQKLEAKVRELEAELDAEQKKHAEA----LKGVRKHERRVKELAYQAE 927
Query: 1059 NMEEEMQRVSKQL--LDSKQHNEELQILVREQDDQIKELKETKLTFEMN 1105
+ + R+ + L SK + + Q EQ K K E++
Sbjct: 928 EDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELD 976
Score = 84.2 bits (199), Expect = 3e-15
Identities = 181/1000 (18%), Positives = 393/1000 (39%), Gaps = 64/1000 (6%)
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
L+ + +LE+E L+ D D + + K+ EN + + ++ L+ L
Sbjct: 8 LAARRRKLEDECTELKK---DIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARL 64
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS-VHLEEQIDALSASKKELALVIENL 685
+E LQ+ + + L D+ Q + D+V + K+ + LE+Q++ L S ++ + L
Sbjct: 65 TKEKKALQEAHQQA---LGDL-QAEEDRVSALTKAKLRLEQQVEDLECSLEQE----KKL 116
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
++D E+ + LE D + + + Q+ L +KL+K +E +S+L ++ E+
Sbjct: 117 RMDTERAK---RKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE-LSQLSLRVEDEQLL 172
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
Q Q KI+E E +E EL ++ R+E+ A L + ++ G
Sbjct: 173 GAQMQ----KKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGA 228
Query: 806 LQEKQKAYSEYTIQEDELVNRLA-VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN 864
+++ + + L L + H+ V + EL ++ L Q
Sbjct: 229 SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQK 288
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKE 924
L+ S+++ + L A++ + K D S K E Q + +
Sbjct: 289 LEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQ 348
Query: 925 IEDLEIEFNTQIESAIRDKKVLNEKYEKN----IEYVTQLEAQLQEYKNNIENLNMNVEE 980
L+ E + ++ + +K+ L + + + + +L QL+E L V+
Sbjct: 349 RGRLQTE-SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA 407
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE-EIIALNQKINNAQVSY 1039
L L ++H ++ + Q+ ++ +++ N A + K E + I +++ A+
Sbjct: 408 LRHDCDLLREQHEEEAEAQAE--LQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKL 465
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETK 1099
+ + E + K ++E+ R+ + D E D + + L+
Sbjct: 466 ALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERA- 524
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQE 1159
E + E M +E ++ + ++ E +E LQE
Sbjct: 525 --LEERRRQEEEM--QRELEAAQRESRGLGTELFRLRHGHEEA-LEALETLKRENKNLQE 579
Query: 1160 QSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE 1219
+ + L ++ I +LE L G Q + + + LE T+ + +++
Sbjct: 580 EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQ 639
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA--FESKYEQLLDSVQS 1277
+++ + + ++ E A L + H E+ + E R + A + K E L+ ++
Sbjct: 640 VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLEL 699
Query: 1278 STQEETNKIVTMEQVTSL-QNKL------QDKEEHL-RNLQEKYADVINQIEILRSEIED 1329
T + + T L Q +L +D+E+ L L E+ + + +L +E+E+
Sbjct: 700 QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEE 759
Query: 1330 EKVAFXXXXXXXXXX------XXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXX 1383
+ A L ++N +++ ++ + + ++++++
Sbjct: 760 LRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQE 819
Query: 1384 XXXXXXXXXXRVNDAEAKVLELTHQLELK-DSEIYQKTHEYTI-TLTQRNDEFENV---- 1437
+ DA EL + + E +KT E T+ L R +E E
Sbjct: 820 RREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG 879
Query: 1438 -RQQLVEYEKRIEDLTYEKESEL-----AILRLKMHENANHYETMQKESEIERVKLIEEL 1491
++Q+ + E ++ +L E ++E A+ ++ HE Q E + + + +++L
Sbjct: 880 GKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDL 939
Query: 1492 NVKITESV-SLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
K+ V S +Q E + +AK + Q L++ E
Sbjct: 940 VDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAE 979
Score = 80.6 bits (190), Expect = 4e-14
Identities = 198/1020 (19%), Positives = 392/1020 (38%), Gaps = 94/1020 (9%)
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
+VN DL + + E++ T+L +ID + K + K+ Q T N
Sbjct: 3 EVNA-DLAARRRKLEDECTELKKDIDDLELTLAKAE-------KEKQAT---------EN 45
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
K + LTEE+ L + VA L +EK LQ ++ + D+ + + L + +L+
Sbjct: 46 K-VKNLTEEMAALDESVARLTKEKKALQ------EAHQQALGDLQAEEDRVSALTKAKLR 98
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK-SVHLEEQIDALSA 673
+E + L QE L+ + + KL +L + V + LEE++ +
Sbjct: 99 LEQQVEDLECSLEQEKK-LRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 157
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
+L+L +E+ +L Q+ IK+L+ E++ +L+ + +K +A ++
Sbjct: 158 ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE-RAARARVEKQRAEAARELE 216
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
EL ++ + + G + E +E ++++ + L A +
Sbjct: 217 ELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA---EGAA 273
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHD-------RVVEKQLLEIEH 846
L + D L Q+ +K SE ++ D+L + L R E QL E +
Sbjct: 274 ELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKI 333
Query: 847 ENKELQKKNQILLEENQNLQI---SLSDMQQHYNALVEKANR-TDLAESESTKYQTQLRD 902
+ +ELQ++ + LQ LS + + L+ + +R LA + + QL +
Sbjct: 334 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 393
Query: 903 LESNLKRITHEHQT------LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN-IE 955
+ H Q L+ ++ +E + + E + A + KYE + I+
Sbjct: 394 ESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQ 453
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
+LE ++ ++ VE N ++K + QT+S D T + +
Sbjct: 454 RTEELEEAKKKLALRLQEAEEGVEAAN-AKCSSLEKAKLRLQTESEDVTLE-LERATSAA 511
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
A L +K + ++ + + + + T+L + + + L K
Sbjct: 512 AALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 571
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+ N+ LQ + + DQ+ ++ E EG S I+ ++A
Sbjct: 572 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGE--KSEIQAALEEAEGALELEETK 629
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ 1195
Q + E ++ + E+ A L Q +E+L L E
Sbjct: 630 TLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRA------VESLQASLDAETRARNEA 683
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ +LK K+E ND L R + + R + A+L K+ A R+ + Q+
Sbjct: 684 L-RLKKKME--GDLNDLELQLGHATRQATEAQAATRLMQ-AQL-KEEQAGRDEE-QRLAA 737
Query: 1256 ELRVQLSAFESKYEQL---LDSVQSSTQ--EETNKIVTME--QVTSLQNKLQDKEEHLRN 1308
EL Q A E + L L+ ++++ + E + ++ E + T N L + L N
Sbjct: 738 ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLN 797
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQS---YKQMQEQ 1365
++K + Q+ E E+ +L+ E + ++M++
Sbjct: 798 QKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKT 857
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL---KDSEIYQ--KT 1420
+ E A+L+++ +V EAKV EL +L+ K +E + +
Sbjct: 858 LEQTVRELQARLEEAE---QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRK 914
Query: 1421 HEYTI------------TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
HE + L + D + ++ ++ Y+++ E+ + + LA R HE
Sbjct: 915 HERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHE 974
Score = 71.7 bits (168), Expect = 2e-11
Identities = 181/991 (18%), Positives = 393/991 (39%), Gaps = 87/991 (8%)
Query: 63 NAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKELSKRSSTTI 122
NA L ++R K + T EL + + + +LA K+K+ K+K E ++
Sbjct: 5 NADLAARRRKLEDECT-EL--KKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESV 61
Query: 123 VRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEK 182
R LGD+ E+D ++ + K+++ E + DL+ + ++
Sbjct: 62 ARLTKEKKALQEAHQQA-LGDLQ------AEEDRVSALTKAKLRL-EQQVEDLECSLEQE 113
Query: 183 DQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQ---QMTKMQENFIAMEAEWKDEK--- 236
++ +A +D +Q ++ K + +DE+
Sbjct: 114 KKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLG 173
Query: 237 QRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLA 296
++ K I+ R LEE + AAR + + ++ A+ELE+
Sbjct: 174 AQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQR 233
Query: 297 KQSIEPSCE---EKTEIEEKGSLEIANMTELTKK-----IELLEHLNCQIRQTNK-ELEN 347
+ + E + E+EE A + L +K EL E ++ R K E E
Sbjct: 234 EGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEK 293
Query: 348 KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
M + A + + + + K R ++ +++ E L + +
Sbjct: 294 SELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE--AKIKVEELQRQLADA--STQR 349
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
+L+ L++ L +KE +IS+ + L QL+ E + +L H
Sbjct: 350 GRLQTESGELSRLLEEKECLISQ---LSRGKALAAQSLEELRRQLEEESKAK---SALAH 403
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVK---DLIEKLKSAEEQITQLNDEIDAANK 524
++ + Q + + E E++ + K ++ + E Q +E++ A K
Sbjct: 404 AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKK 463
Query: 525 NMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRL-------TEELHHLSQKVAELEE 576
+ L+L++ ++ ++ +K S K +RL T EL + A L++
Sbjct: 464 KL-------ALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 516
Query: 577 EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQK 636
++ +L+ L + R E ++ +++ + + + L + ++ L L+++
Sbjct: 517 KQRHLERAL---EERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRE 573
Query: 637 YDEVEDKLADISQLQSDQVCSEIKSV-HLEEQIDALSASKKELALVIEN----LKLDKEQ 691
++++++D+ +DQV KS+ LE+ AL K E+ +E L+L++ +
Sbjct: 574 NKNLQEEISDL----TDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETK 629
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQF 751
+L K ++ KL +E +L + + + E + L ++ +
Sbjct: 630 TLRIQLELSQVKAEVDRKLAEKDEECANLR-RNHQRAVESLQASLDAETRARNEALRLKK 688
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
++ + + +L + + + ++ ++ ++ + + R +R A +L Q ++
Sbjct: 689 KMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALER 748
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
S + +EL L R+ E++LLE L +N LL + + L+ +D
Sbjct: 749 RASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE---AD 805
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
+ Q + E A AE ++ K T + LK+ + + + KK +E E
Sbjct: 806 LAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK-EQDTSAHLERMKKTLEQTVRE 864
Query: 932 FNTQIE----SAIRDKKVLNEKYEKNI-EYVTQLEAQ----------LQEYKNNIENLNM 976
++E +A+R K +K E + E +L+A+ +++++ ++ L
Sbjct: 865 LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAY 924
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
EE ++ NL + V K Q++ Y Q+
Sbjct: 925 QAEE-DRKNLARMQDLVDKLQSKVKSYKRQF 954
Score = 65.7 bits (153), Expect = 1e-09
Identities = 110/592 (18%), Positives = 251/592 (42%), Gaps = 37/592 (6%)
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKL 1014
E L A+ ++ ++ L ++++L ++ L +K Q + + + TE+ +
Sbjct: 3 EVNADLAARRRKLEDECTELKKDIDDL-ELTLAKAEKEKQATENKVKNLTEEMAALDESV 61
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
L K+K A Q + + Q + + ++KL + ++E++E +++ K +D+
Sbjct: 62 ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL-RLEQQVEDLECSLEQEKKLRMDT 120
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
++ +L+ ++ + + + + K E + K + + ++ +
Sbjct: 121 ERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKI 180
Query: 1135 XXXXXXXLKVQEEEEFIQE-RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
+++EE E + R+ +++Q A+ EL+E ++ + + +
Sbjct: 181 KELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKRE 240
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
++ +L+ +LE+ ++ +TVA LR + + G ++ L Q + Q+ +K
Sbjct: 241 AELGRLRRELEEAALRHE---ATVAALRRKQAEGAAELGEQVDSL--QRVRQK---LEKE 292
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKY 1313
+ ELR+++ + E L + S+ E+ + +Q++ + K+++ + L + +
Sbjct: 293 KSELRMEVDDLAANVETLTRAKASA--EKLCRTYE-DQLSEAKIKVEELQRQLADASTQR 349
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ + L S + +EK +LR +Q++E+S +
Sbjct: 350 GRLQTESGEL-SRLLEEKECLISQLSRGKALAAQSLEELR------RQLEEES----KAK 398
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
+A +AEA+ EL L ++E+ Q +Y QR +E
Sbjct: 399 SALAHAVQALRHDCDLLREQHEEEAEAQA-ELQRLLSKANAEVAQWRSKYEADAIQRTEE 457
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E +++L R+++ E+ E A + E A ++ ++E E V L EL
Sbjct: 458 LEEAKKKLA---LRLQEA--EEGVEAANAKCSSLEKAK----LRLQTESEDVTL--ELER 506
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
+ + +L+K+ L +ALEE + EMQ LE + E L E+ L++
Sbjct: 507 ATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRH 558
Score = 62.5 bits (145), Expect = 1e-08
Identities = 109/606 (17%), Positives = 240/606 (39%), Gaps = 47/606 (7%)
Query: 957 VTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+ + E + Q +N ++NL + L++ L + Q+ + E ++++A
Sbjct: 33 LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEE-DRVSA 91
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN-MEEEMQRVSKQLLDSK 1075
L K K + L Q++ + + S + E KL T + + +E +++ + + D+
Sbjct: 92 LTKAK----LRLEQQVEDLECSL-----EQEKKLRMDTERAKRKLEGDLKLTQESVADAA 142
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
Q ++L+ ++++D ++ +L + + + G + I+ + A ++
Sbjct: 143 QDKQQLEEKLKKKDSELSQL-----SLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 197
Query: 1136 XXXXXXLKVQEEEEF--IQERSVLQEQSAKLNTELQE-CYTKIIQLETLNTELTGHDVVN 1192
++ Q E ++E S E++ + +E C + +L L EL + +
Sbjct: 198 RAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRH 257
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQREADF 1250
+ + L+ K + E + ++ +R + + E+ +L + L + +A
Sbjct: 258 EATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASA 317
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+K QLS + K E+L + ++ + ++ T + L L++KE + L
Sbjct: 318 EKLCRTYEDQLSEAKIKVEELQRQLADASTQR-GRLQT--ESGELSRLLEEKECLISQLS 374
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
A +E LR ++E+E A LR + ++ E+
Sbjct: 375 RGKALAAQSLEELRRQLEEESKAKSALAHAVQA--------LRHDCDLLREQHEEEA--- 423
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
E A+L++ + EA ++ T +LE ++ + E +
Sbjct: 424 -EAQAELQRLLSKANAEVAQWRSKY---EADAIQRTEELEEAKKKLALRLQEAEEGVEAA 479
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
N + ++ + + + ED+T E E + + + H E +E + ++ E
Sbjct: 480 NAKCSSLEKAKLRLQTESEDVTLELERATSAAAA-LDKKQRHLERALEERRRQEEEMQRE 538
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L ES L ++ L EE + ALE + E L +EI++L + V S
Sbjct: 539 LEAAQRESRGLGTELFRLRHGHEEALE-------ALETLKRENKNLQEEISDLTDQVSLS 591
Query: 1551 SSKIQK 1556
IQ+
Sbjct: 592 GKSIQE 597
Score = 57.2 bits (132), Expect = 5e-07
Identities = 138/704 (19%), Positives = 286/704 (40%), Gaps = 53/704 (7%)
Query: 233 KDEKQRLLKDIESK--DVRISSLEEANKLLEAA--RFEISLEHSKLAQELEQXXXXXXXX 288
K ++L + E + + +I E +L +A+ R + E +L++ LE+
Sbjct: 314 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL 373
Query: 289 XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELEN 347
LA QS+E + E E K +A+ + L +LL + + + EL+
Sbjct: 374 SRGKA-LAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQR 431
Query: 348 KLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
L+ E SK + I R A K + Q + E + + + K + E
Sbjct: 432 LLSKANAE--VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV-EAANAKCSSLEK 488
Query: 408 AKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
AKL + +S + L + E S + Q + E Q+ +E
Sbjct: 489 AKLRLQTESEDVTL-ELERATSAAAALDKKQRHLERALEERRRQEE-EMQRELEAAQRES 546
Query: 468 VGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMI 527
G TE + + E+ + L + +K N K+L E++ +Q++ I K
Sbjct: 547 RGLGTE-LFRLRHGHEEALEAL-ETLKREN-KNLQEEISDLTDQVSLSGKSIQELEKTK- 602
Query: 528 KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL--TEELHHLSQKVAELEEEKGNLQLHL 585
K K +++ + + ++ ++ ++L ++ + +K+AE +EE NL+ +
Sbjct: 603 KALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRN- 661
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETR-LKAISLLESQKFDLVQEL-HILQQKYDEVEDK 643
R +ES + ++ E A L+ +E DL +L H +Q +
Sbjct: 662 ----HQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 715
Query: 644 LADISQLQSDQVCSEIK---SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+QL+ +Q + + + L EQ AL LA +E L+ EQ + + E
Sbjct: 716 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 775
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQER 760
+ + +L +N L ++ +K+ A+ +++L ++ Q + + + I +
Sbjct: 776 QELLEATERLNLLHSQNTGLLNQKKKLEAD-LAQLSGEVEEAAQERREAEEKAKKAITDA 834
Query: 761 DLYIENI--ESELSKYKSRICR-LEESIAVMEDRRYSLERKADQLGSYLQEKQKAY---- 813
+ E + E + S + R+ + LE+++ ++ R E+ A + G +K +A
Sbjct: 835 AMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL 894
Query: 814 -SEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-------------- 858
+E ++ + L + H+R V++ + E + K L + ++
Sbjct: 895 EAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 954
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD 902
E Q +L+ ++ + L + R D+AE+++ K + + RD
Sbjct: 955 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 998
>BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 92.7 bits (220), Expect = 1e-17
Identities = 167/834 (20%), Positives = 354/834 (42%), Gaps = 75/834 (8%)
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE--ELHH 566
+ Q+ ++ E D K+ ++VK + KL +I F + +R E ++
Sbjct: 155 QTQLKEVLRENDLLRKD-VEVKES---KLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
++ ++EE ++Q+ + I+ D+ ++ + ++ + T ++ L + F
Sbjct: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQRDL-NQLFQQDSSSRTGEPCVAELTEENF-- 267
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
Q LH E E + ++ L+ E++ +E Q L+A + + ++E L+
Sbjct: 268 -QRLHA------EHERQAKELFLLRKTLEEMELR---IETQKQTLNARDESIKKLLEMLQ 317
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
T +D E + + + + ++ L ++ EK ++ E+ + + S
Sbjct: 318 SKGLSAKATEEDHERTRR--LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSA 375
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+T+ + I+ +D I ++E L + I L+ + A+ + R E + Q+ Y
Sbjct: 376 -KTK-ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER---EEEMKQMEVYR 430
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
+ ++ ++EL ++ A + + EI +EL +K+ LL L+
Sbjct: 431 SHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLE 490
Query: 867 I---SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
SD +QH L E E + QT++ L L+ E +T++ +K K
Sbjct: 491 TLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----EKETMLNKKTK 543
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
+I+D+ E TQ I D K + + E+ + + + IENL + + K
Sbjct: 544 QIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIENLQEQLRDKEK 592
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+ + + V+ Q + + T+ + L L +K+ I L ++ + + +
Sbjct: 593 Q-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRDRDEREKQEEI 647
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL-------K 1096
+Y+ L K+ ++ ++ LLD K+H L ++D ++K L K
Sbjct: 648 DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKK 707
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E L E + K + + P MSD +++ K Q E + + E
Sbjct: 708 EECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS--KAQAEVDRLLE-- 763
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS--KLEQLNTENDNL 1213
+L+E + N + ++ Q++ N ++ ++ ++EQ+ + KS LE+ DNL
Sbjct: 764 ILKEVENEKNDKDKKIAELERQVKDQNKKVA--NLKHKEQVEKKKSAQMLEEARRREDNL 821
Query: 1214 LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLD 1273
+ +L+ S+ D R E+ E ++ + Q A+ + + + E + E+LL
Sbjct: 822 NDSSQQLQDSLRKK-DDRIEELEEALRESV-QITAEREMVLAQEESARTNAEKQVEELLM 879
Query: 1274 SVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE 1326
+++ QE E+ K +++S Q L +KE HL NL+ + + ++ ++ E
Sbjct: 880 AMEKVKQELESMK----AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQE 929
Score = 88.2 bits (209), Expect = 2e-16
Identities = 180/903 (19%), Positives = 369/903 (40%), Gaps = 79/903 (8%)
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRIC--------RLEESIAVMEDRRYSLERK 798
+QTQ + ++E DL +++E + SK S + L++ A+ +D +
Sbjct: 154 LQTQ--LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIW 211
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDEL-----VNRLAVLMDHDRVVEKQLLEIEHEN----- 848
+Q +E Q +DEL +N+L R E + E+ EN
Sbjct: 212 KEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
Query: 849 --KELQKKNQILLEEN-QNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLE 904
E Q K LL + + +++ + +Q NA E + ++ +S+ + D E
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
Query: 905 -----SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKYEKNIEYV 957
+ + H ++L+ QK+KE L E + + E+A K L E +
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKI 391
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ +E L++ + I+ L N ++ E ++ + KQ +++ N++ +L
Sbjct: 392 SSMERGLRDLEEEIQMLKSN----GALSTEEREEEM-KQMEVYRSHSKFMKNKVEQLKEE 446
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L K+ + L +K Q + + +L++ T+L ++ +++ ++ Q DSKQH
Sbjct: 447 LSSKEAQWEELKKKAAGLQAE----IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 502
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E L+ + ++ + L+ + + + E M+ T + + D A
Sbjct: 503 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT-KQIQDMAEEKGTQAGEIHD 561
Query: 1138 XXXXLKVQEEEEFIQERSV--LQEQ---SAKLNTELQECYTKIIQLETLNTEL---TGHD 1189
L V+E + + ++ + LQEQ K + L+E K +Q +T NT+ T +
Sbjct: 562 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE-RVKSLQADTTNTDTALTTLEE 620
Query: 1190 VVNQEQ--INQLKSKLEQLNTEN----DNLLSTVAELRSSISSAVDQRGFEIAELW--KQ 1241
+ +++ I +LK + ++ E DN + +L+ +S + A L K+
Sbjct: 621 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 680
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
H + + K + L+ A E K E+ L ++S ++ + + +++Q
Sbjct: 681 HASSLASSGLKKDSRLKTLEIALEQKKEECL-KMESQLKKAHEAALEARASPEMSDRIQH 739
Query: 1302 KEEHLRNLQEK----YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
E + +++ A+V +EIL+ E+E+EK ++ +N+
Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILK-EVENEK-------NDKDKKIAELERQVKDQNK 791
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
++ + + +++AQ+ + + ++ D+ K + +LE E
Sbjct: 792 KVANLKHKEQVE-KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 850
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
Q T E + L Q N +Q+ E +E + E ES A L ++ ET
Sbjct: 851 QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS-STQQSLAEKETHL 909
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALEE---EVAKTNEMQTALENQEIEIV 1534
ER K +EE+ E++ + N AL E KT E AL+ ++ +V
Sbjct: 910 TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLV 969
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMY 1594
+ T QN ++ + + +S + Q + + + + LL+ + + L +Y
Sbjct: 970 QQLKQQT--QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLE-LDQNRSKLKLY 1026
Query: 1595 MLH 1597
+ H
Sbjct: 1027 IGH 1029
Score = 82.6 bits (195), Expect = 1e-14
Identities = 129/615 (20%), Positives = 283/615 (46%), Gaps = 77/615 (12%)
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+ +KD K+ S E + L +EI N + ++KQM+ + SK +
Sbjct: 384 IEMKD--SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME-VYRSHSKFMKNKV 440
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E +L EEL + EL+++ LQ + ++ ++ +K E+ L +T+L+
Sbjct: 441 E--QLKEELSSKEAQWEELKKKAAGLQAEI------GQVKQELSRKDTELLAL-QTKLET 491
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++ +Q D Q + +L++ E + A I Q + D + + LEE+ L+
Sbjct: 492 LT---NQFSDSKQHIEVLKESLTAKEQRAA-ILQTEVDAL-----RLRLEEKETMLNKKT 542
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSA--EKI 732
K++ + E +++ +KD+ + KE +N LQ I+ + L DK ++MS+ E++
Sbjct: 543 KQIQDMAEEKGTQAGEIHD-LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 601
Query: 733 SELLAKINHE-------EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
L A + E++ + + I+ ++RD + E+ YK + L+E +
Sbjct: 602 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 661
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
++++ E++A L L+E + + +++D + L + ++ + ++ L++E
Sbjct: 662 SLLQGDLS--EKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKK---EECLKME 714
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+L+K ++ LE + + +SD QH + + + ES+K Q ++ L
Sbjct: 715 ---SQLKKAHEAALEARASPE--MSDRIQHLEREITRY------KDESSKAQAEVDRLLE 763
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
LK + +E K K+I +LE + Q +KKV N K+++ +E + L+
Sbjct: 764 ILKEVENEKN----DKDKKIAELERQVKDQ------NKKVANLKHKEQVEKKKSAQ-MLE 812
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI 1025
E + +NLN + ++L +L D +++ E+ + E ++ A + E+
Sbjct: 813 EARRREDNLNDSSQQLQD-SLRKKDDRIEE--------LEEALRESVQITA-----EREM 858
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
+ ++ +A+ + V + + + +LE+M+ ++ + L + + H L+
Sbjct: 859 VLAQEE--SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 916
Query: 1086 REQDDQIKELKETKL 1100
R+ +++ E+K+ L
Sbjct: 917 RKHLEEVLEMKQEAL 931
Score = 78.2 bits (184), Expect = 2e-13
Identities = 127/726 (17%), Positives = 294/726 (40%), Gaps = 48/726 (6%)
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY--V 957
+ DL++ LK + E+ L +K E+++ ++ + ++ E+ + E +
Sbjct: 151 IMDLQTQLKEVLRENDLL--RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
Query: 958 TQLEAQLQEYKNNIENLNMNVEELN-----KMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
T + Q + + +++ M ++ L + +L + + +T P E
Sbjct: 209 TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---------EE 1063
+L+A +++ +E+ L + + ++ + ++ LE ++ EE
Sbjct: 269 RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+++L +++ H L+ L+ +++ + L+E N P + T+ M D
Sbjct: 329 DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD 388
Query: 1124 DA-NNVDXXXXXXXXXXXXLK------VQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
++++ LK +E EE +++ V + S + ++++ ++
Sbjct: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELS 448
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
E EL Q +I Q+K +L + +TE LL+ +L + + D + +
Sbjct: 449 SKEAQWEELKKKAAGLQAEIGQVKQELSRKDTE---LLALQTKLETLTNQFSDSK--QHI 503
Query: 1237 ELWKQHLA---QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
E+ K+ L QR A Q LR++L E+ + +Q +E+ + + +
Sbjct: 504 EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK 563
Query: 1294 SL----QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXX 1349
+ + K+ ++ + NLQE+ D Q+ L+ ++ +
Sbjct: 564 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 623
Query: 1350 XDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT-HQ 1408
RT + K+ +++ EE KK +++ EA +L+L H
Sbjct: 624 EKERTIER-LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
Query: 1409 LELKDSEIYQKTHEYT--ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKM 1466
L S + + + T I L Q+ +E + QL + + + E I L+
Sbjct: 683 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 742
Query: 1467 HENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTAL 1526
E+ + ++E++R L+E L E +K++AEL + ++++ K ++
Sbjct: 743 EITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE 800
Query: 1527 ENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPR 1586
+ ++ + + +E ++ + SS ++Q + K R E+L+ + +E +
Sbjct: 801 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLR----KKDDRIEELEEAL-RESVQITAE 855
Query: 1587 AELDLA 1592
E+ LA
Sbjct: 856 REMVLA 861
Score = 69.7 bits (163), Expect = 8e-11
Identities = 122/565 (21%), Positives = 253/565 (44%), Gaps = 74/565 (13%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK 542
EQLK+EL+ K+ ++L +K + +I Q+ E+ K L L+ +
Sbjct: 441 EQLKEELSS--KEAQWEELKKKAAGLQAEIGQVKQELSR--------KDTELLALQTKLE 490
Query: 543 TIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM 602
T+ N + SDS + I L E L Q+ A L+ E L+L L + ++ M+ K++
Sbjct: 491 TLTN--QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET--MLNKKT-KQI 545
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD-----------ISQLQ 651
+M T+ I L+ +++++LQ+K + ++++L D + LQ
Sbjct: 546 QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK-- 709
+D ++ LEE AL+ ++ + + E D+ + I + + D +D+ K
Sbjct: 606 ADTTNTDTALTTLEE---ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
Query: 710 -LQNYIQEN----MDLTDK--------LEKMSAEKISELLAKINHEEQSKIQTQF----- 751
LQ + E +DL + L+K S K E+ + EE K+++Q
Sbjct: 663 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 722
Query: 752 -GIDAKIQ-ERDLYIENIESELSKYK-------SRICRLEESIAVMEDRRYSLERKADQL 802
++A+ E I+++E E+++YK + + RL E + +E+ + ++K +L
Sbjct: 723 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAEL 782
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE-LQKKNQILLEE 861
++++ K + +E + A +++ R E L + + ++ L+KK+ + E
Sbjct: 783 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL----RDLESNLKRITHEHQTL 917
+ L+ S+ + L ++ + AE + + + ++LES +++ Q+L
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ--LQEYKNNIENLN 975
+K+ + +L E +E +VL K E + +++ +A L E ++ +
Sbjct: 903 -AEKETHLTNLRAERRKHLE------EVLEMKQEALLAAISEKDANIALLELSSSKKKTQ 955
Query: 976 MNVEELNKMNLELIDKHVQKQQTQS 1000
V L + L+ + KQQTQ+
Sbjct: 956 EEVAALKREKDRLVQQ--LKQQTQN 978
Score = 62.1 bits (144), Expect = 2e-08
Identities = 127/750 (16%), Positives = 302/750 (40%), Gaps = 71/750 (9%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
K + + K+ ME + DL+E+I Q++++ +T
Sbjct: 378 KALQTVIEMKDSKISSMERGLRDLEEEI----QMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQR----------LLKDIESKDVRISSLEEANKLLE 261
+ K ++ +++E + EA+W++ K++ + +++ KD + +L+ + L
Sbjct: 434 KFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETL- 492
Query: 262 AARFEISLEHSKLAQE---LEQXXXXXXXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLE 317
+F S +H ++ +E ++ L + E +KT +I++ +
Sbjct: 493 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 552
Query: 318 IANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRN 377
E+ ++L+ ++ K++EN + + K +SS ++ L + + +
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 378 TA--------SKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQSLNKDLVDKE 425
TA ++ + +L + + +K+ K ++ L+ + L DL +KE
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+ + KD+ + L++ +Q E E K++ QL
Sbjct: 673 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKE---------------ECLKMESQL 717
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK----VKSNHKLKLKQMQ 541
K+ ++ ++ ++++ E +IT+ DE A + + +K K + +
Sbjct: 718 KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK 777
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
K + +V D NK++ L + +K A++ EE + +L DS + ++ + KK
Sbjct: 778 KIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL--NDSSQQLQDSLRKK 835
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
+E L E +++ + ++ L QE +VE+ L + ++V E++S
Sbjct: 836 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELES 890
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK--EDIMNKLQNYIQENMD 719
+ + S ++KE L NL+ ++ + + +++ + I K N ++
Sbjct: 891 MKAKLSSTQQSLAEKETHLT--NLRAERRKHLEEVLEMKQEALLAAISEKDANIAL--LE 946
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRI 778
L+ +K E + K +Q K QTQ + D + ++ S + +K
Sbjct: 947 LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSP 1006
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY-------SEYTIQEDELVNRLAVLM 831
++ + + ++ R L+ L + ++ + Y + +D+ +
Sbjct: 1007 DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQK 1066
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEE 861
++ +L + E +N ELQ+ +L++
Sbjct: 1067 MTRGQLQDELEKGERDNAELQEFANAILQQ 1096
Score = 50.8 bits (116), Expect = 4e-05
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 34/412 (8%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
I L+++L+++ END L V S +SS+++ I W L ++E +K E
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNS----IKTFWSPEL-KKERALRKDEA 205
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ---NKLQDKEEHLRNLQEK 1312
+++ ++ +Y VQ Q I ++ +Q N+L ++ R +
Sbjct: 206 S---KITIWKEQYRV----VQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNIN 1371
A++ + R E E+ A +LR E Q +++SI +
Sbjct: 259 VAELTEE-NFQRLHAEHERQA----KELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN 1431
E Q K S R+ +AE V H LE S + QK E ++ + +
Sbjct: 314 EM-LQSKGLSAKATEEDHERTRRLAEAEMHV----HHLE---SLLEQKEKENSMLREEMH 365
Query: 1432 DEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI---ERVKLI 1488
FEN K ++ + K+S+++ + + + + ++ + ER + +
Sbjct: 366 RRFENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEM 423
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
+++ V + S + +V +L + L + A+ E++ + EI + E++ +
Sbjct: 424 KQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
A +K++ + SD+KQ + ++ KE A+ + E+D L +++
Sbjct: 484 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
Score = 45.2 bits (102), Expect = 0.002
Identities = 95/552 (17%), Positives = 219/552 (39%), Gaps = 35/552 (6%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 470 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 526
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 527 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 585
Query: 171 TILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA 230
+ D +++++ + +++ TT + ++ + +++E E
Sbjct: 586 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA----EKERTIERLKEQRDRDER 641
Query: 231 EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXX 290
E ++E KD++ ++S L+ EA+ ++ S LA +
Sbjct: 642 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 701
Query: 291 XXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLA 350
++ ++ E + + + +LE E++ +I+ LE + + + + + ++
Sbjct: 702 ALEQKKEECLK--MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 759
Query: 351 TMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKL 410
+ K V + I+ ++K ++++ + +KK + + +
Sbjct: 760 RLLEILKEVENEKNDKDKKIA-----ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 411 EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+LN + + +KD ++ L +Q+ ++ M T
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEEL------EEALRESVQITAEREMVLAQEESART 868
Query: 471 NTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
N E V E+ E++KQEL E + + L E +T L E K++ +V
Sbjct: 869 NAEKQVEELLMAMEKVKQEL--ESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEV 923
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
L++KQ + + S+ D+N ++ L+ ++VA L+ EK L L
Sbjct: 924 -----LEMKQ-EALLAAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
Query: 590 SGRM-IESDVYK 600
RM + +D Y+
Sbjct: 977 QNRMKLMADNYE 988
>BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 92.7 bits (220), Expect = 1e-17
Identities = 167/834 (20%), Positives = 354/834 (42%), Gaps = 75/834 (8%)
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE--ELHH 566
+ Q+ ++ E D K+ ++VK + KL +I F + +R E ++
Sbjct: 155 QTQLKEVLRENDLLRKD-VEVKES---KLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
++ ++EE ++Q+ + I+ D+ ++ + ++ + T ++ L + F
Sbjct: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQRDL-NQLFQQDSSSRTGEPCVAELTEENF-- 267
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
Q LH E E + ++ L+ E++ +E Q L+A + + ++E L+
Sbjct: 268 -QRLHA------EHERQAKELFLLRKTLEEMELR---IETQKQTLNARDESIKKLLEMLQ 317
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
T +D E + + + + ++ L ++ EK ++ E+ + + S
Sbjct: 318 SKGLSAKATEEDHERTRR--LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSA 375
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+T+ + I+ +D I ++E L + I L+ + A+ + R E + Q+ Y
Sbjct: 376 -KTK-ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER---EEEMKQMEVYR 430
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
+ ++ ++EL ++ A + + EI +EL +K+ LL L+
Sbjct: 431 SHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLE 490
Query: 867 I---SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
SD +QH L E E + QT++ L L+ E +T++ +K K
Sbjct: 491 TLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----EKETMLNKKTK 543
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
+I+D+ E TQ I D K + + E+ + + + IENL + + K
Sbjct: 544 QIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIENLQEQLRDKEK 592
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+ + + V+ Q + + T+ + L L +K+ I L ++ + + +
Sbjct: 593 Q-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRDRDEREKQEEI 647
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL-------K 1096
+Y+ L K+ ++ ++ LLD K+H L ++D ++K L K
Sbjct: 648 DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKK 707
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E L E + K + + P MSD +++ K Q E + + E
Sbjct: 708 EECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS--KAQAEVDRLLE-- 763
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS--KLEQLNTENDNL 1213
+L+E + N + ++ Q++ N ++ ++ ++EQ+ + KS LE+ DNL
Sbjct: 764 ILKEVENEKNDKDKKIAELERQVKDQNKKVA--NLKHKEQVEKKKSAQMLEEARRREDNL 821
Query: 1214 LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLD 1273
+ +L+ S+ D R E+ E ++ + Q A+ + + + E + E+LL
Sbjct: 822 NDSSQQLQDSLRKK-DDRIEELEEALRESV-QITAEREMVLAQEESARTNAEKQVEELLM 879
Query: 1274 SVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE 1326
+++ QE E+ K +++S Q L +KE HL NL+ + + ++ ++ E
Sbjct: 880 AMEKVKQELESMK----AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQE 929
Score = 88.2 bits (209), Expect = 2e-16
Identities = 180/903 (19%), Positives = 369/903 (40%), Gaps = 79/903 (8%)
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRIC--------RLEESIAVMEDRRYSLERK 798
+QTQ + ++E DL +++E + SK S + L++ A+ +D +
Sbjct: 154 LQTQ--LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIW 211
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDEL-----VNRLAVLMDHDRVVEKQLLEIEHEN----- 848
+Q +E Q +DEL +N+L R E + E+ EN
Sbjct: 212 KEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
Query: 849 --KELQKKNQILLEEN-QNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLE 904
E Q K LL + + +++ + +Q NA E + ++ +S+ + D E
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
Query: 905 -----SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKYEKNIEYV 957
+ + H ++L+ QK+KE L E + + E+A K L E +
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKI 391
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ +E L++ + I+ L N ++ E ++ + KQ +++ N++ +L
Sbjct: 392 SSMERGLRDLEEEIQMLKSN----GALSTEEREEEM-KQMEVYRSHSKFMKNKVEQLKEE 446
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L K+ + L +K Q + + +L++ T+L ++ +++ ++ Q DSKQH
Sbjct: 447 LSSKEAQWEELKKKAAGLQAE----IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 502
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E L+ + ++ + L+ + + + E M+ T + + D A
Sbjct: 503 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT-KQIQDMAEEKGTQAGEIHD 561
Query: 1138 XXXXLKVQEEEEFIQERSV--LQEQ---SAKLNTELQECYTKIIQLETLNTEL---TGHD 1189
L V+E + + ++ + LQEQ K + L+E K +Q +T NT+ T +
Sbjct: 562 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE-RVKSLQADTTNTDTALTTLEE 620
Query: 1190 VVNQEQ--INQLKSKLEQLNTEN----DNLLSTVAELRSSISSAVDQRGFEIAELW--KQ 1241
+ +++ I +LK + ++ E DN + +L+ +S + A L K+
Sbjct: 621 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 680
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
H + + K + L+ A E K E+ L ++S ++ + + +++Q
Sbjct: 681 HASSLASSGLKKDSRLKTLEIALEQKKEECL-KMESQLKKAHEAALEARASPEMSDRIQH 739
Query: 1302 KEEHLRNLQEK----YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
E + +++ A+V +EIL+ E+E+EK ++ +N+
Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILK-EVENEK-------NDKDKKIAELERQVKDQNK 791
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
++ + + +++AQ+ + + ++ D+ K + +LE E
Sbjct: 792 KVANLKHKEQVE-KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 850
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
Q T E + L Q N +Q+ E +E + E ES A L ++ ET
Sbjct: 851 QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS-STQQSLAEKETHL 909
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALEE---EVAKTNEMQTALENQEIEIV 1534
ER K +EE+ E++ + N AL E KT E AL+ ++ +V
Sbjct: 910 TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLV 969
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMY 1594
+ T QN ++ + + +S + Q + + + + LL+ + + L +Y
Sbjct: 970 QQLKQQT--QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLE-LDQNRSKLKLY 1026
Query: 1595 MLH 1597
+ H
Sbjct: 1027 IGH 1029
Score = 82.6 bits (195), Expect = 1e-14
Identities = 129/615 (20%), Positives = 283/615 (46%), Gaps = 77/615 (12%)
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+ +KD K+ S E + L +EI N + ++KQM+ + SK +
Sbjct: 384 IEMKD--SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME-VYRSHSKFMKNKV 440
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E +L EEL + EL+++ LQ + ++ ++ +K E+ L +T+L+
Sbjct: 441 E--QLKEELSSKEAQWEELKKKAAGLQAEI------GQVKQELSRKDTELLAL-QTKLET 491
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++ +Q D Q + +L++ E + A I Q + D + + LEE+ L+
Sbjct: 492 LT---NQFSDSKQHIEVLKESLTAKEQRAA-ILQTEVDAL-----RLRLEEKETMLNKKT 542
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSA--EKI 732
K++ + E +++ +KD+ + KE +N LQ I+ + L DK ++MS+ E++
Sbjct: 543 KQIQDMAEEKGTQAGEIHD-LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 601
Query: 733 SELLAKINHE-------EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
L A + E++ + + I+ ++RD + E+ YK + L+E +
Sbjct: 602 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 661
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
++++ E++A L L+E + + +++D + L + ++ + ++ L++E
Sbjct: 662 SLLQGDLS--EKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKK---EECLKME 714
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+L+K ++ LE + + +SD QH + + + ES+K Q ++ L
Sbjct: 715 ---SQLKKAHEAALEARASPE--MSDRIQHLEREITRY------KDESSKAQAEVDRLLE 763
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
LK + +E K K+I +LE + Q +KKV N K+++ +E + L+
Sbjct: 764 ILKEVENEKN----DKDKKIAELERQVKDQ------NKKVANLKHKEQVEKKKSAQ-MLE 812
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI 1025
E + +NLN + ++L +L D +++ E+ + E ++ A + E+
Sbjct: 813 EARRREDNLNDSSQQLQD-SLRKKDDRIEE--------LEEALRESVQITA-----EREM 858
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
+ ++ +A+ + V + + + +LE+M+ ++ + L + + H L+
Sbjct: 859 VLAQEE--SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 916
Query: 1086 REQDDQIKELKETKL 1100
R+ +++ E+K+ L
Sbjct: 917 RKHLEEVLEMKQEAL 931
Score = 78.2 bits (184), Expect = 2e-13
Identities = 127/726 (17%), Positives = 294/726 (40%), Gaps = 48/726 (6%)
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY--V 957
+ DL++ LK + E+ L +K E+++ ++ + ++ E+ + E +
Sbjct: 151 IMDLQTQLKEVLRENDLL--RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
Query: 958 TQLEAQLQEYKNNIENLNMNVEELN-----KMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
T + Q + + +++ M ++ L + +L + + +T P E
Sbjct: 209 TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---------EE 1063
+L+A +++ +E+ L + + ++ + ++ LE ++ EE
Sbjct: 269 RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+++L +++ H L+ L+ +++ + L+E N P + T+ M D
Sbjct: 329 DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD 388
Query: 1124 DA-NNVDXXXXXXXXXXXXLK------VQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
++++ LK +E EE +++ V + S + ++++ ++
Sbjct: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELS 448
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
E EL Q +I Q+K +L + +TE LL+ +L + + D + +
Sbjct: 449 SKEAQWEELKKKAAGLQAEIGQVKQELSRKDTE---LLALQTKLETLTNQFSDSK--QHI 503
Query: 1237 ELWKQHLA---QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
E+ K+ L QR A Q LR++L E+ + +Q +E+ + + +
Sbjct: 504 EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK 563
Query: 1294 SL----QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXX 1349
+ + K+ ++ + NLQE+ D Q+ L+ ++ +
Sbjct: 564 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 623
Query: 1350 XDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT-HQ 1408
RT + K+ +++ EE KK +++ EA +L+L H
Sbjct: 624 EKERTIER-LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
Query: 1409 LELKDSEIYQKTHEYT--ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKM 1466
L S + + + T I L Q+ +E + QL + + + E I L+
Sbjct: 683 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 742
Query: 1467 HENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTAL 1526
E+ + ++E++R L+E L E +K++AEL + ++++ K ++
Sbjct: 743 EITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE 800
Query: 1527 ENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPR 1586
+ ++ + + +E ++ + SS ++Q + K R E+L+ + +E +
Sbjct: 801 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLR----KKDDRIEELEEAL-RESVQITAE 855
Query: 1587 AELDLA 1592
E+ LA
Sbjct: 856 REMVLA 861
Score = 69.7 bits (163), Expect = 8e-11
Identities = 122/565 (21%), Positives = 253/565 (44%), Gaps = 74/565 (13%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK 542
EQLK+EL+ K+ ++L +K + +I Q+ E+ K L L+ +
Sbjct: 441 EQLKEELSS--KEAQWEELKKKAAGLQAEIGQVKQELSR--------KDTELLALQTKLE 490
Query: 543 TIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM 602
T+ N + SDS + I L E L Q+ A L+ E L+L L + ++ M+ K++
Sbjct: 491 TLTN--QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET--MLNKKT-KQI 545
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD-----------ISQLQ 651
+M T+ I L+ +++++LQ+K + ++++L D + LQ
Sbjct: 546 QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK-- 709
+D ++ LEE AL+ ++ + + E D+ + I + + D +D+ K
Sbjct: 606 ADTTNTDTALTTLEE---ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
Query: 710 -LQNYIQEN----MDLTDK--------LEKMSAEKISELLAKINHEEQSKIQTQF----- 751
LQ + E +DL + L+K S K E+ + EE K+++Q
Sbjct: 663 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 722
Query: 752 -GIDAKIQ-ERDLYIENIESELSKYK-------SRICRLEESIAVMEDRRYSLERKADQL 802
++A+ E I+++E E+++YK + + RL E + +E+ + ++K +L
Sbjct: 723 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAEL 782
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE-LQKKNQILLEE 861
++++ K + +E + A +++ R E L + + ++ L+KK+ + E
Sbjct: 783 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL----RDLESNLKRITHEHQTL 917
+ L+ S+ + L ++ + AE + + + ++LES +++ Q+L
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ--LQEYKNNIENLN 975
+K+ + +L E +E +VL K E + +++ +A L E ++ +
Sbjct: 903 -AEKETHLTNLRAERRKHLE------EVLEMKQEALLAAISEKDANIALLELSSSKKKTQ 955
Query: 976 MNVEELNKMNLELIDKHVQKQQTQS 1000
V L + L+ + KQQTQ+
Sbjct: 956 EEVAALKREKDRLVQQ--LKQQTQN 978
Score = 62.1 bits (144), Expect = 2e-08
Identities = 127/750 (16%), Positives = 302/750 (40%), Gaps = 71/750 (9%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
K + + K+ ME + DL+E+I Q++++ +T
Sbjct: 378 KALQTVIEMKDSKISSMERGLRDLEEEI----QMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQR----------LLKDIESKDVRISSLEEANKLLE 261
+ K ++ +++E + EA+W++ K++ + +++ KD + +L+ + L
Sbjct: 434 KFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETL- 492
Query: 262 AARFEISLEHSKLAQE---LEQXXXXXXXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLE 317
+F S +H ++ +E ++ L + E +KT +I++ +
Sbjct: 493 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 552
Query: 318 IANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRN 377
E+ ++L+ ++ K++EN + + K +SS ++ L + + +
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 378 TA--------SKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQSLNKDLVDKE 425
TA ++ + +L + + +K+ K ++ L+ + L DL +KE
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+ + KD+ + L++ +Q E E K++ QL
Sbjct: 673 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKE---------------ECLKMESQL 717
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK----VKSNHKLKLKQMQ 541
K+ ++ ++ ++++ E +IT+ DE A + + +K K + +
Sbjct: 718 KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK 777
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
K + +V D NK++ L + +K A++ EE + +L DS + ++ + KK
Sbjct: 778 KIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL--NDSSQQLQDSLRKK 835
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
+E L E +++ + ++ L QE +VE+ L + ++V E++S
Sbjct: 836 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELES 890
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK--EDIMNKLQNYIQENMD 719
+ + S ++KE L NL+ ++ + + +++ + I K N ++
Sbjct: 891 MKAKLSSTQQSLAEKETHLT--NLRAERRKHLEEVLEMKQEALLAAISEKDANIAL--LE 946
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRI 778
L+ +K E + K +Q K QTQ + D + ++ S + +K
Sbjct: 947 LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSP 1006
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY-------SEYTIQEDELVNRLAVLM 831
++ + + ++ R L+ L + ++ + Y + +D+ +
Sbjct: 1007 DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQK 1066
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEE 861
++ +L + E +N ELQ+ +L++
Sbjct: 1067 MTRGQLQDELEKGERDNAELQEFANAILQQ 1096
Score = 50.8 bits (116), Expect = 4e-05
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 34/412 (8%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
I L+++L+++ END L V S +SS+++ I W L ++E +K E
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNS----IKTFWSPEL-KKERALRKDEA 205
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ---NKLQDKEEHLRNLQEK 1312
+++ ++ +Y VQ Q I ++ +Q N+L ++ R +
Sbjct: 206 S---KITIWKEQYRV----VQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNIN 1371
A++ + R E E+ A +LR E Q +++SI +
Sbjct: 259 VAELTEE-NFQRLHAEHERQA----KELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN 1431
E Q K S R+ +AE V H LE S + QK E ++ + +
Sbjct: 314 EM-LQSKGLSAKATEEDHERTRRLAEAEMHV----HHLE---SLLEQKEKENSMLREEMH 365
Query: 1432 DEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI---ERVKLI 1488
FEN K ++ + K+S+++ + + + + ++ + ER + +
Sbjct: 366 RRFENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEM 423
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
+++ V + S + +V +L + L + A+ E++ + EI + E++ +
Sbjct: 424 KQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
A +K++ + SD+KQ + ++ KE A+ + E+D L +++
Sbjct: 484 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
Score = 45.2 bits (102), Expect = 0.002
Identities = 95/552 (17%), Positives = 219/552 (39%), Gaps = 35/552 (6%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 470 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 526
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 527 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 585
Query: 171 TILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA 230
+ D +++++ + +++ TT + ++ + +++E E
Sbjct: 586 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA----EKERTIERLKEQRDRDER 641
Query: 231 EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXX 290
E ++E KD++ ++S L+ EA+ ++ S LA +
Sbjct: 642 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 701
Query: 291 XXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLA 350
++ ++ E + + + +LE E++ +I+ LE + + + + + ++
Sbjct: 702 ALEQKKEECLK--MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 759
Query: 351 TMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKL 410
+ K V + I+ ++K ++++ + +KK + + +
Sbjct: 760 RLLEILKEVENEKNDKDKKIA-----ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 411 EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+LN + + +KD ++ L +Q+ ++ M T
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEEL------EEALRESVQITAEREMVLAQEESART 868
Query: 471 NTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
N E V E+ E++KQEL E + + L E +T L E K++ +V
Sbjct: 869 NAEKQVEELLMAMEKVKQEL--ESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEV 923
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
L++KQ + + S+ D+N ++ L+ ++VA L+ EK L L
Sbjct: 924 -----LEMKQ-EALLAAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
Query: 590 SGRM-IESDVYK 600
RM + +D Y+
Sbjct: 977 QNRMKLMADNYE 988
>AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransferase 9
protein.
Length = 978
Score = 92.7 bits (220), Expect = 1e-17
Identities = 174/871 (19%), Positives = 373/871 (42%), Gaps = 77/871 (8%)
Query: 522 ANKNMI-KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
ANK +I +++ +K ++QK N + + ++ ++ + S K++ LE E
Sbjct: 115 ANKLVISELRIKLAIKEAEIQKLHANLT-ANQLSQSLITCNDSQE--SSKLSSLETEPVK 171
Query: 581 LQLHLVDY---DSGRMIESDVYKKMIE--MENLAETRLKAISLLESQKFDL-VQELHILQ 634
L H V D + + Y+K + + + E R K I + E++ DL V H
Sbjct: 172 LGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI-EAENSDLKVNMAHRTS 230
Query: 635 QKY---DEVEDKLADISQLQSDQV--CSEIKSVH--LEEQIDALSASKKELALVIENLKL 687
Q +E+ +K ++ S+L+S+ CS++ ++ LEE+I A S+ + A + + L
Sbjct: 231 QFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELME 290
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
E++ ++ + E I + + +++ ++EK E++ L K + + + +
Sbjct: 291 KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQ-IERLEAQLEKKDQQFKEQE 349
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+T + I + ++E+++ L++ K + + E++ E +L+ +Q+
Sbjct: 350 KTMSMLQQDIICKQHHLESLDRLLTESKGEMKK--ENMKKDE----ALKALQNQVSEETI 403
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE----NKELQKKNQILLEENQ 863
+ ++ S I ++ELV L L + EKQL + E KEL+ KN L E ++
Sbjct: 404 KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 463
Query: 864 NLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
I +QQ L ++ R E TK + Q+ LE L++ Q++
Sbjct: 464 QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK----------QRES 513
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
E L + + ESA + + +K + Q++ ++ +YK EEL+K
Sbjct: 514 SAEKLR-KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYK----------EELSK 562
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
M E++ H+++ + Q +++ L++K + +++ Q S + +
Sbjct: 563 MEKEIM--HLKRDGENKAMHFSQLDMILDQTKTELEKKTNAV----KELEKLQHSTETEL 616
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFE 1103
++ K T+L+N E++ +QL + + ++ Q+ + E+ IK+L +
Sbjct: 617 TEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECK 676
Query: 1104 MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV-LQEQSA 1162
M I + E + + + + N + + ++E ++++ + L+
Sbjct: 677 MEI-EDEKQELLEMDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE 733
Query: 1163 KLNTELQECYTKI----IQLETLNTELTGHDVV---NQEQINQLKSKLEQLNTENDNLLS 1215
K EL+EC +I +L+ +L + + N+++I+QLK ++E+ + S
Sbjct: 734 KSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMES 793
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE-HELRVQLSAFESKYEQLLDS 1274
+ E I++ + ++ + K L + + TE E R Q + + E+L
Sbjct: 794 VMKEQEQYIATQC-KEAIDLGQ--KLRLTREQVQNSHTELAEARHQQVQAQREIERLSSE 850
Query: 1275 VQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF 1334
++ Q K + + +E HL A + +I+ L +E+E K A+
Sbjct: 851 LEDMKQLSKEKDAHGNHLAEELGASKVREAHLE------ARMQAEIKKLSAEVESLKEAY 904
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQ 1365
++ S +Q+ EQ
Sbjct: 905 HMEMISHQENHAKWKISADSQKSSVQQLNEQ 935
Score = 88.6 bits (210), Expect = 2e-16
Identities = 141/787 (17%), Positives = 346/787 (43%), Gaps = 51/787 (6%)
Query: 220 KMQENFIAMEAEWKDEKQRLL-KDIESKDVRISSLEEANKL--LEAARFEISLEHSKLAQ 276
+++ I +EAE D K + + + + ++ LE+A+ LE+ + + L +
Sbjct: 206 ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK 265
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE---IANMTELTKKIELLEH 333
+LE+ L ++ +E + E+ +E + E I E KKI L +H
Sbjct: 266 QLEEKIVAYSSIAAKNAELEQELMEKN-EKIRSLETNINTEHEKICLAFEKAKKIHLEQH 324
Query: 334 --LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS-QLS 390
+ QI + +LE K + K +S + +I ++ + ++ + ++
Sbjct: 325 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQD---IICKQHHLESLDRLLTESKGEMK 381
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
E + +D K +N++++ + ++ L+ ++ +E V+ K
Sbjct: 382 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 441
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE---LNDEIKDVNVKDLIEKL 505
L+ + ++ SL + + Q+Q+ Q+ N E++D K +EK
Sbjct: 442 EEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK--LEKQ 499
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSN---HKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
S EQ Q E A ++ K H+ LK+ QK I+ E+ + E
Sbjct: 500 VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR-QKVIELTGTARQVKIEMDQYKE 558
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
EL + +++ L+ + N +H D MI ++ + N + K E++
Sbjct: 559 ELSKMEKEIMHLKRDGENKAMHFSQLD---MILDQTKTELEKKTNAVKELEKLQHSTETE 615
Query: 623 KFDLVQELHILQQKYDEVEDKL-ADISQLQSDQVCSEIKSVHLEEQ---IDALSASKKEL 678
+ +Q+ +L+ + +L + + QLQ + + + LEE+ I L+A +E
Sbjct: 616 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC 675
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ IE+ +K++L + L+ ++ + +M + + +M +KI +L
Sbjct: 676 KMEIED---EKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEME-QKIIKLEGT 731
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ E+S+++ + + +I+ + ++N + +L + + + + E+ I+ ++ +++
Sbjct: 732 L---EKSELELK-ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 787
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
++ S ++E+++ + + +L +L + + + +L E H+ + Q++ + L
Sbjct: 788 MKEMESVMKEQEQYIATQCKEAIDLGQKLRLTREQVQNSHTELAEARHQQVQAQREIERL 847
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESE-STKYQTQLRDLESNLKRITHEHQTL 917
E ++++ + H N L E+ + + E+ + Q +++ L + ++ + +
Sbjct: 848 SSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME 907
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
++ ++ +I ++Q +S+++ LNE+ EK + +L+E ++ + NL+
Sbjct: 908 MISHQENHAKWKISADSQ-KSSVQQ---LNEQLEK-------AKLELEEAQDTVSNLHQQ 956
Query: 978 VEELNKM 984
V++ N++
Sbjct: 957 VQDRNEV 963
Score = 86.6 bits (205), Expect = 7e-16
Identities = 140/734 (19%), Positives = 314/734 (42%), Gaps = 61/734 (8%)
Query: 472 TEDVNEIAKVQEQLKQEL----NDEIKDVNVK-DLIEKLKSAEEQITQLNDEIDAANKNM 526
T+ +++ +++QL++++ + K+ ++ +L+EK + T +N E +
Sbjct: 254 TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF 313
Query: 527 IKVKSNHKLKLKQMQKTIDNF--------SKVSDSNKEIVRLTEEL----HHLSQKVAEL 574
K K H + K+M+K I+ + + K + L +++ HHL L
Sbjct: 314 EKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL 373
Query: 575 EEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHIL 633
E KG ++ + D + +++ V ++ I++ L S LE K +LV L+ L
Sbjct: 374 TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD-------SALEICKEELVLHLNQL 426
Query: 634 QQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL- 692
+ ++ E +L + +S++V K + ++ +L + ++ ++ L+ ++ L
Sbjct: 427 EGNKEKFEKQL----KKKSEEVYCLQKELKIKNH--SLQETSEQNVILQHTLQQQQQMLQ 480
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN---HEEQSKIQT 749
TI++ + ED KL+ + + K + SAEK+ ++ K HE K Q
Sbjct: 481 QETIRN--GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQK 538
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
+ ++ + ++ + ELSK + I L+ L+ DQ + L++K
Sbjct: 539 VIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHFSQLDMILDQTKTELEKK 598
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
A E + L + V+E +L E K ++ Q L + Q Q+SL
Sbjct: 599 TNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSL 658
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
++ Y + + + E + +L +++ LK E + Q+ ++ L+
Sbjct: 659 ---EEKYTTIKDLTAELRECKMEIEDEKQELLEMDQALK----ERNWELKQRAAQVTHLD 711
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLE 987
+ ++K++ K E +E + E +L+E IE+LN ++ + E
Sbjct: 712 MTIRE--HRGEMEQKII--KLEGTLE---KSELELKECNKQIESLNDKLQNAKEQLREKE 764
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA-LNQKINNAQVSYMS--MVS 1044
I +++ +Q E+ + ++ +++K++++ I + I+ Q ++ V
Sbjct: 765 FIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQCKEAIDLGQKLRLTREQVQ 824
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ ++LA+ + + E++R+S +L D KQ ++E +++ K + E
Sbjct: 825 NSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEA 884
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + E +S+ +E + +A +++ + ++ +Q+ L EQ K
Sbjct: 885 RM-QAEIKKLSAEVESLK-EAYHMEMISHQENHAKWKISADSQKSSVQQ---LNEQLEKA 939
Query: 1165 NTELQECYTKIIQL 1178
EL+E + L
Sbjct: 940 KLELEEAQDTVSNL 953
Score = 83.4 bits (197), Expect = 6e-15
Identities = 177/917 (19%), Positives = 369/917 (40%), Gaps = 86/917 (9%)
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN 740
V+ L ++ + +LEN K++I+ + + EN +L ++ + E++ +I
Sbjct: 8 VMAQLTESRQSILKLESELEN-KDEILRDKFSLMNENRELKVRVAAQN-ERLDLCQQEIE 65
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK-SRICRLEES-IAVMEDRRYSLERK 798
+ I +R+L+ +S LSKY+ S E+ I E + +
Sbjct: 66 SSRVELRSLEKIISQLPLKRELF--GFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL 123
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+L E QK ++ T ++L L D + LE E + + +
Sbjct: 124 RIKLAIKEAEIQKLHANLTA--NQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESV 181
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL- 917
++NQ+ + ++ + RT L + E+ DL+ N+ T + Q +
Sbjct: 182 KDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAEN-----SDLKVNMAHRTSQFQLIQ 236
Query: 918 --IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK---YEKNIEYVTQLEAQLQEYKNNIE 972
+++K LE E + + +K L EK Y +LE +L E I
Sbjct: 237 EELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIR 296
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+L N+ ++ +K + Q + +Q I +L A L++KD++ + +
Sbjct: 297 SLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQ----IERLEAQLEKKDQQFKEQEKTM 352
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
+ Q + ES T M++E + + L + E I VR+ D +
Sbjct: 353 SMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSAL 412
Query: 1093 KELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE---EEE 1149
+ KE +L +N + ++ S++ + Q +
Sbjct: 413 EICKE-ELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 471
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKII-QLETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
Q++ +LQ+++ + N EL++ TK+ Q+ L EL + E++ +++ K E
Sbjct: 472 LQQQQQMLQQETIR-NGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 530
Query: 1209 ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKY 1268
E D V EL + Q E+ + +K+ L++ E + + + + F S+
Sbjct: 531 EADLKRQKVIEL----TGTARQVKIEMDQ-YKEELSKMEKEIMHLKRDGENKAMHF-SQL 584
Query: 1269 EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+ +LD ++ +++TN + +E KLQ E + + + + E+L +E++
Sbjct: 585 DMILDQTKTELEKKTNAVKELE-------KLQHSTE------TELTEALQKREVLETELQ 631
Query: 1329 DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
+ +LR Q + E+ I + A+L++
Sbjct: 632 N--------AHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKM------ 677
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT-ITLTQRNDEFENVRQQLVEYEKR 1447
+ D + ++LE+ L+ ++ E+ Q+ + T + +T R E + Q++++ E
Sbjct: 678 -----EIEDEKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGE-MEQKIIKLEGT 731
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
+E +SEL ++ E E++ +++ K E+L K + +++++
Sbjct: 732 LE------KSEL-----ELKECNKQIESLN--DKLQNAK--EQLREKEFIMLQNEQEISQ 776
Query: 1508 LNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ-KHVSFASDTKQ 1566
L K +E + EM++ ++ QE I T E +L +R + ++Q H A Q
Sbjct: 777 LKKEIERTQQRMKEMESVMKEQEQYIATQCKEAIDLGQKLRLTREQVQNSHTELAEARHQ 836
Query: 1567 GRDEQLD-NTMNKELLD 1582
Q + ++ EL D
Sbjct: 837 QVQAQREIERLSSELED 853
Score = 41.9 bits (94), Expect = 0.018
Identities = 76/406 (18%), Positives = 168/406 (41%), Gaps = 25/406 (6%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ TK ++ K +E + L + ++ ++V + L+ A+ L++ ++
Sbjct: 589 DQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELR 648
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELL 331
L + L + +E E++ +E +L+ N EL ++ +
Sbjct: 649 DVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDEKQELLEMDQALKERNW-ELKQRAAQV 707
Query: 332 EHLNCQIRQTNKELENKLATM-GTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
HL+ IR+ E+E K+ + GT K+ + K + K+++ QL
Sbjct: 708 THLDMTIREHRGEMEQKIIKLEGTLEKSELELKE------CNKQIESLNDKLQNAKEQLR 761
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXX--XXXXXXGKDTL 448
++ N+ EI++L+ I+ + + + E V+ E++ G+
Sbjct: 762 ----EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQCKEAIDLGQKLR 817
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKS 507
+ + Q+++ H E H + ++ ++ E +KQ L+ E KD + L E+L +
Sbjct: 818 LTREQVQN-SHTELAEARHQQVQAQREIERLSSELEDMKQ-LSKE-KDAHGNHLAEELGA 874
Query: 508 AEEQITQLNDEIDAANKNMI----KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIV-RLTE 562
++ + L + A K + +K + +++ Q+ + +DS K V +L E
Sbjct: 875 SKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNE 934
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
+L ++ E ++ N LH D +IE+ + + EN+
Sbjct: 935 QLEKAKLELEEAQDTVSN--LHQQVQDRNEVIEAANEALLTKGENV 978
Score = 34.3 bits (75), Expect = 3.7
Identities = 80/441 (18%), Positives = 174/441 (39%), Gaps = 39/441 (8%)
Query: 1160 QSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTENDNLLST 1216
+++++ +L E I++LE+ EL D + +++ + + E ++ +N+ L
Sbjct: 4 KTSEVMAQLTESRQSILKLES---ELENKDEILRDKFSLMNENRELKVRVAAQNERLDLC 60
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
E+ SS V+ R E ++ Q +RE F + + Q+S+F +K ++ +
Sbjct: 61 QQEIESS---RVELRSLE--KIISQLPLKREL-FGFKSYLSKYQMSSFSNKEDRCIGCC- 113
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKY-ADVINQIEILRSEIEDEKVAFX 1335
E NK+V ++ L+ KL KE ++ L A+ ++Q I ++ ++
Sbjct: 114 -----EANKLV----ISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSS 164
Query: 1336 XXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
++ +NQ Q + +E +L
Sbjct: 165 LETEPVKLGGHQVAESVKDQNQHTMNKQYE------KERQRLVTGIEELRTKLIQIEAEN 218
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIED--LTY 1453
+D + + T Q +L E+ +K + + E QL+ EK++E+ + Y
Sbjct: 219 SDLKVNMAHRTSQFQLIQEELLEKASNSS----KLESEMTKKCSQLLTLEKQLEEKIVAY 274
Query: 1454 EK-ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKAL 1512
++ A L ++ E +++ E K+ L + + + L +Q E+ K +
Sbjct: 275 SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC--LAFEKAKKIHL-EQHKEMEKQI 331
Query: 1513 EEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQL 1572
E A+ + + QE + L +I Q+ + + + + +DE L
Sbjct: 332 ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 391
Query: 1573 DNTMNKELLDAVPRAELDLAM 1593
N+ + + +LD A+
Sbjct: 392 KALQNQVSEETIKVRQLDSAL 412
>AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein.
Length = 1116
Score = 92.7 bits (220), Expect = 1e-17
Identities = 167/834 (20%), Positives = 354/834 (42%), Gaps = 75/834 (8%)
Query: 509 EEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE--ELHH 566
+ Q+ ++ E D K+ ++VK + KL +I F + +R E ++
Sbjct: 155 QTQLKEVLRENDLLRKD-VEVKES---KLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
++ ++EE ++Q+ + I+ D+ ++ + ++ + T ++ L + F
Sbjct: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQRDL-NQLFQQDSSSRTGEPCVAELTEENF-- 267
Query: 627 VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLK 686
Q LH E E + ++ L+ E++ +E Q L+A + + ++E L+
Sbjct: 268 -QRLHA------EHERQAKELFLLRKTLEEMELR---IETQKQTLNARDESIKKLLEMLQ 317
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSK 746
T +D E + + + + ++ L ++ EK ++ E+ + + S
Sbjct: 318 SKGLSAKATEEDHERTRR--LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSA 375
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYL 806
+T+ + I+ +D I ++E L + I L+ + A+ + R E + Q+ Y
Sbjct: 376 -KTK-ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER---EEEMKQMEVYR 430
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
+ ++ ++EL ++ A + + EI +EL +K+ LL L+
Sbjct: 431 SHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLE 490
Query: 867 I---SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
SD +QH L E E + QT++ L L+ E +T++ +K K
Sbjct: 491 TLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----EKETMLNKKTK 543
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
+I+D+ E TQ I D K + + E+ + + + IENL + + K
Sbjct: 544 QIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIENLQEQLRDKEK 592
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+ + + V+ Q + + T+ + L L +K+ I L ++ + + +
Sbjct: 593 Q-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRDRDEREKQEEI 647
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL-------K 1096
+Y+ L K+ ++ ++ LLD K+H L ++D ++K L K
Sbjct: 648 DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKK 707
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E L E + K + + P MSD +++ K Q E + + E
Sbjct: 708 EECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS--KAQAEVDRLLE-- 763
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS--KLEQLNTENDNL 1213
+L+E + N + ++ Q++ N ++ ++ ++EQ+ + KS LE+ DNL
Sbjct: 764 ILKEVENEKNDKDKKIAELERQVKDQNKKVA--NLKHKEQVEKKKSAQMLEEARRREDNL 821
Query: 1214 LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLD 1273
+ +L+ S+ D R E+ E ++ + Q A+ + + + E + E+LL
Sbjct: 822 NDSSQQLQDSLRKK-DDRIEELEEALRESV-QITAEREMVLAQEESARTNAEKQVEELLM 879
Query: 1274 SVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE 1326
+++ QE E+ K +++S Q L +KE HL NL+ + + ++ ++ E
Sbjct: 880 AMEKVKQELESMK----AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQE 929
Score = 88.2 bits (209), Expect = 2e-16
Identities = 180/903 (19%), Positives = 369/903 (40%), Gaps = 79/903 (8%)
Query: 747 IQTQFGIDAKIQERDLYIENIESELSKYKSRIC--------RLEESIAVMEDRRYSLERK 798
+QTQ + ++E DL +++E + SK S + L++ A+ +D +
Sbjct: 154 LQTQ--LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIW 211
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDEL-----VNRLAVLMDHDRVVEKQLLEIEHEN----- 848
+Q +E Q +DEL +N+L R E + E+ EN
Sbjct: 212 KEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
Query: 849 --KELQKKNQILLEEN-QNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLE 904
E Q K LL + + +++ + +Q NA E + ++ +S+ + D E
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
Query: 905 -----SNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA--IRDKKVLNEKYEKNIEYV 957
+ + H ++L+ QK+KE L E + + E+A K L E +
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKI 391
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ +E L++ + I+ L N ++ E ++ + KQ +++ N++ +L
Sbjct: 392 SSMERGLRDLEEEIQMLKSN----GALSTEEREEEM-KQMEVYRSHSKFMKNKVEQLKEE 446
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
L K+ + L +K Q + + +L++ T+L ++ +++ ++ Q DSKQH
Sbjct: 447 LSSKEAQWEELKKKAAGLQAE----IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 502
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E L+ + ++ + L+ + + + E M+ T + + D A
Sbjct: 503 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT-KQIQDMAEEKGTQAGEIHD 561
Query: 1138 XXXXLKVQEEEEFIQERSV--LQEQ---SAKLNTELQECYTKIIQLETLNTEL---TGHD 1189
L V+E + + ++ + LQEQ K + L+E K +Q +T NT+ T +
Sbjct: 562 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE-RVKSLQADTTNTDTALTTLEE 620
Query: 1190 VVNQEQ--INQLKSKLEQLNTEN----DNLLSTVAELRSSISSAVDQRGFEIAELW--KQ 1241
+ +++ I +LK + ++ E DN + +L+ +S + A L K+
Sbjct: 621 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 680
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
H + + K + L+ A E K E+ L ++S ++ + + +++Q
Sbjct: 681 HASSLASSGLKKDSRLKTLEIALEQKKEECL-KMESQLKKAHEAALEARASPEMSDRIQH 739
Query: 1302 KEEHLRNLQEK----YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
E + +++ A+V +EIL+ E+E+EK ++ +N+
Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILK-EVENEK-------NDKDKKIAELERQVKDQNK 791
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIY 1417
++ + + +++AQ+ + + ++ D+ K + +LE E
Sbjct: 792 KVANLKHKEQVE-KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 850
Query: 1418 QKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQ 1477
Q T E + L Q N +Q+ E +E + E ES A L ++ ET
Sbjct: 851 QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS-STQQSLAEKETHL 909
Query: 1478 KESEIERVKLIEELNVKITESVSLNKQVAELNKALEE---EVAKTNEMQTALENQEIEIV 1534
ER K +EE+ E++ + N AL E KT E AL+ ++ +V
Sbjct: 910 TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLV 969
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMY 1594
+ T QN ++ + + +S + Q + + + + LL+ + + L +Y
Sbjct: 970 QQLKQQT--QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLE-LDQNRSKLKLY 1026
Query: 1595 MLH 1597
+ H
Sbjct: 1027 IGH 1029
Score = 82.6 bits (195), Expect = 1e-14
Identities = 129/615 (20%), Positives = 283/615 (46%), Gaps = 77/615 (12%)
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+ +KD K+ S E + L +EI N + ++KQM+ + SK +
Sbjct: 384 IEMKD--SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME-VYRSHSKFMKNKV 440
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E +L EEL + EL+++ LQ + ++ ++ +K E+ L +T+L+
Sbjct: 441 E--QLKEELSSKEAQWEELKKKAAGLQAEI------GQVKQELSRKDTELLAL-QTKLET 491
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++ +Q D Q + +L++ E + A I Q + D + + LEE+ L+
Sbjct: 492 LT---NQFSDSKQHIEVLKESLTAKEQRAA-ILQTEVDAL-----RLRLEEKETMLNKKT 542
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSA--EKI 732
K++ + E +++ +KD+ + KE +N LQ I+ + L DK ++MS+ E++
Sbjct: 543 KQIQDMAEEKGTQAGEIHD-LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 601
Query: 733 SELLAKINHE-------EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
L A + E++ + + I+ ++RD + E+ YK + L+E +
Sbjct: 602 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 661
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
++++ E++A L L+E + + +++D + L + ++ + ++ L++E
Sbjct: 662 SLLQGDLS--EKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKK---EECLKME 714
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+L+K ++ LE + + +SD QH + + + ES+K Q ++ L
Sbjct: 715 ---SQLKKAHEAALEARASPE--MSDRIQHLEREITRY------KDESSKAQAEVDRLLE 763
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
LK + +E K K+I +LE + Q +KKV N K+++ +E + L+
Sbjct: 764 ILKEVENEKN----DKDKKIAELERQVKDQ------NKKVANLKHKEQVEKKKSAQ-MLE 812
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI 1025
E + +NLN + ++L +L D +++ E+ + E ++ A + E+
Sbjct: 813 EARRREDNLNDSSQQLQD-SLRKKDDRIEE--------LEEALRESVQITA-----EREM 858
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
+ ++ +A+ + V + + + +LE+M+ ++ + L + + H L+
Sbjct: 859 VLAQEE--SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 916
Query: 1086 REQDDQIKELKETKL 1100
R+ +++ E+K+ L
Sbjct: 917 RKHLEEVLEMKQEAL 931
Score = 78.2 bits (184), Expect = 2e-13
Identities = 127/726 (17%), Positives = 294/726 (40%), Gaps = 48/726 (6%)
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY--V 957
+ DL++ LK + E+ L +K E+++ ++ + ++ E+ + E +
Sbjct: 151 IMDLQTQLKEVLRENDLL--RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
Query: 958 TQLEAQLQEYKNNIENLNMNVEELN-----KMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
T + Q + + +++ M ++ L + +L + + +T P E
Sbjct: 209 TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---------EE 1063
+L+A +++ +E+ L + + ++ + ++ LE ++ EE
Sbjct: 269 RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+++L +++ H L+ L+ +++ + L+E N P + T+ M D
Sbjct: 329 DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD 388
Query: 1124 DA-NNVDXXXXXXXXXXXXLK------VQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
++++ LK +E EE +++ V + S + ++++ ++
Sbjct: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELS 448
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
E EL Q +I Q+K +L + +TE LL+ +L + + D + +
Sbjct: 449 SKEAQWEELKKKAAGLQAEIGQVKQELSRKDTE---LLALQTKLETLTNQFSDSK--QHI 503
Query: 1237 ELWKQHLA---QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
E+ K+ L QR A Q LR++L E+ + +Q +E+ + + +
Sbjct: 504 EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK 563
Query: 1294 SL----QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXX 1349
+ + K+ ++ + NLQE+ D Q+ L+ ++ +
Sbjct: 564 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 623
Query: 1350 XDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT-HQ 1408
RT + K+ +++ EE KK +++ EA +L+L H
Sbjct: 624 EKERTIER-LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
Query: 1409 LELKDSEIYQKTHEYT--ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKM 1466
L S + + + T I L Q+ +E + QL + + + E I L+
Sbjct: 683 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 742
Query: 1467 HENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTAL 1526
E+ + ++E++R L+E L E +K++AEL + ++++ K ++
Sbjct: 743 EITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE 800
Query: 1527 ENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPR 1586
+ ++ + + +E ++ + SS ++Q + K R E+L+ + +E +
Sbjct: 801 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLR----KKDDRIEELEEAL-RESVQITAE 855
Query: 1587 AELDLA 1592
E+ LA
Sbjct: 856 REMVLA 861
Score = 69.7 bits (163), Expect = 8e-11
Identities = 122/565 (21%), Positives = 253/565 (44%), Gaps = 74/565 (13%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK 542
EQLK+EL+ K+ ++L +K + +I Q+ E+ K L L+ +
Sbjct: 441 EQLKEELSS--KEAQWEELKKKAAGLQAEIGQVKQELSR--------KDTELLALQTKLE 490
Query: 543 TIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM 602
T+ N + SDS + I L E L Q+ A L+ E L+L L + ++ M+ K++
Sbjct: 491 TLTN--QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET--MLNKKT-KQI 545
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD-----------ISQLQ 651
+M T+ I L+ +++++LQ+K + ++++L D + LQ
Sbjct: 546 QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK-- 709
+D ++ LEE AL+ ++ + + E D+ + I + + D +D+ K
Sbjct: 606 ADTTNTDTALTTLEE---ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
Query: 710 -LQNYIQEN----MDLTDK--------LEKMSAEKISELLAKINHEEQSKIQTQF----- 751
LQ + E +DL + L+K S K E+ + EE K+++Q
Sbjct: 663 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 722
Query: 752 -GIDAKIQ-ERDLYIENIESELSKYK-------SRICRLEESIAVMEDRRYSLERKADQL 802
++A+ E I+++E E+++YK + + RL E + +E+ + ++K +L
Sbjct: 723 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAEL 782
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE-LQKKNQILLEE 861
++++ K + +E + A +++ R E L + + ++ L+KK+ + E
Sbjct: 783 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842
Query: 862 NQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL----RDLESNLKRITHEHQTL 917
+ L+ S+ + L ++ + AE + + + ++LES +++ Q+L
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ--LQEYKNNIENLN 975
+K+ + +L E +E +VL K E + +++ +A L E ++ +
Sbjct: 903 -AEKETHLTNLRAERRKHLE------EVLEMKQEALLAAISEKDANIALLELSSSKKKTQ 955
Query: 976 MNVEELNKMNLELIDKHVQKQQTQS 1000
V L + L+ + KQQTQ+
Sbjct: 956 EEVAALKREKDRLVQQ--LKQQTQN 978
Score = 62.1 bits (144), Expect = 2e-08
Identities = 127/750 (16%), Positives = 302/750 (40%), Gaps = 71/750 (9%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
K + + K+ ME + DL+E+I Q++++ +T
Sbjct: 378 KALQTVIEMKDSKISSMERGLRDLEEEI----QMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQR----------LLKDIESKDVRISSLEEANKLLE 261
+ K ++ +++E + EA+W++ K++ + +++ KD + +L+ + L
Sbjct: 434 KFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETL- 492
Query: 262 AARFEISLEHSKLAQE---LEQXXXXXXXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLE 317
+F S +H ++ +E ++ L + E +KT +I++ +
Sbjct: 493 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 552
Query: 318 IANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRN 377
E+ ++L+ ++ K++EN + + K +SS ++ L + + +
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 378 TA--------SKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQSLNKDLVDKE 425
TA ++ + +L + + +K+ K ++ L+ + L DL +KE
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672
Query: 426 YVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL 485
+ + KD+ + L++ +Q E E K++ QL
Sbjct: 673 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKE---------------ECLKMESQL 717
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK----VKSNHKLKLKQMQ 541
K+ ++ ++ ++++ E +IT+ DE A + + +K K + +
Sbjct: 718 KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK 777
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
K + +V D NK++ L + +K A++ EE + +L DS + ++ + KK
Sbjct: 778 KIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL--NDSSQQLQDSLRKK 835
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
+E L E +++ + ++ L QE +VE+ L + ++V E++S
Sbjct: 836 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELES 890
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDK--EDIMNKLQNYIQENMD 719
+ + S ++KE L NL+ ++ + + +++ + I K N ++
Sbjct: 891 MKAKLSSTQQSLAEKETHLT--NLRAERRKHLEEVLEMKQEALLAAISEKDANIAL--LE 946
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRI 778
L+ +K E + K +Q K QTQ + D + ++ S + +K
Sbjct: 947 LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSP 1006
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY-------SEYTIQEDELVNRLAVLM 831
++ + + ++ R L+ L + ++ + Y + +D+ +
Sbjct: 1007 DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQK 1066
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEE 861
++ +L + E +N ELQ+ +L++
Sbjct: 1067 MTRGQLQDELEKGERDNAELQEFANAILQQ 1096
Score = 50.8 bits (116), Expect = 4e-05
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 34/412 (8%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
I L+++L+++ END L V S +SS+++ I W L ++E +K E
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNS----IKTFWSPEL-KKERALRKDEA 205
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ---NKLQDKEEHLRNLQEK 1312
+++ ++ +Y VQ Q I ++ +Q N+L ++ R +
Sbjct: 206 S---KITIWKEQYRV----VQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNIN 1371
A++ + R E E+ A +LR E Q +++SI +
Sbjct: 259 VAELTEE-NFQRLHAEHERQA----KELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
Query: 1372 EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRN 1431
E Q K S R+ +AE V H LE S + QK E ++ + +
Sbjct: 314 EM-LQSKGLSAKATEEDHERTRRLAEAEMHV----HHLE---SLLEQKEKENSMLREEMH 365
Query: 1432 DEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEI---ERVKLI 1488
FEN K ++ + K+S+++ + + + + ++ + ER + +
Sbjct: 366 RRFENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEM 423
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
+++ V + S + +V +L + L + A+ E++ + EI + E++ +
Sbjct: 424 KQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
A +K++ + SD+KQ + ++ KE A+ + E+D L +++
Sbjct: 484 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
Score = 45.2 bits (102), Expect = 0.002
Identities = 95/552 (17%), Positives = 219/552 (39%), Gaps = 35/552 (6%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 470 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 526
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 527 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 585
Query: 171 TILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA 230
+ D +++++ + +++ TT + ++ + +++E E
Sbjct: 586 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA----EKERTIERLKEQRDRDER 641
Query: 231 EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXX 290
E ++E KD++ ++S L+ EA+ ++ S LA +
Sbjct: 642 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 701
Query: 291 XXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLA 350
++ ++ E + + + +LE E++ +I+ LE + + + + + ++
Sbjct: 702 ALEQKKEECLK--MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 759
Query: 351 TMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKL 410
+ K V + I+ ++K ++++ + +KK + + +
Sbjct: 760 RLLEILKEVENEKNDKDKKIA-----ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 411 EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+LN + + +KD ++ L +Q+ ++ M T
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEEL------EEALRESVQITAEREMVLAQEESART 868
Query: 471 NTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
N E V E+ E++KQEL E + + L E +T L E K++ +V
Sbjct: 869 NAEKQVEELLMAMEKVKQEL--ESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEV 923
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
L++KQ + + S+ D+N ++ L+ ++VA L+ EK L L
Sbjct: 924 -----LEMKQ-EALLAAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
Query: 590 SGRM-IESDVYK 600
RM + +D Y+
Sbjct: 977 QNRMKLMADNYE 988
>AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1044
Score = 92.3 bits (219), Expect = 1e-17
Identities = 171/858 (19%), Positives = 380/858 (44%), Gaps = 77/858 (8%)
Query: 522 ANKNMI-KVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
ANK +I +++ +K ++QK N + + ++ ++ + S K++ LE E
Sbjct: 181 ANKLVISELRIKLAIKEAEIQKLHANLT-ANQLSQSLITCNDSQE--SSKLSSLETEPVK 237
Query: 581 LQLHLVDY---DSGRMIESDVYKKMIE--MENLAETRLKAISLLESQKFDL-VQELHILQ 634
L H V D + + Y+K + + + E R K I + E++ DL V H
Sbjct: 238 LGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI-EAENSDLKVNMAHRTS 296
Query: 635 QKY---DEVEDKLADISQLQSDQV--CSEIKSVH--LEEQIDALSASKKELALVIENLKL 687
Q +E+ +K ++ S+L+S+ CS++ ++ LEE+I A S+ + A + + L
Sbjct: 297 QFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELME 356
Query: 688 DKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
E++ ++ + E I + + +++ ++EK E++ L K + + + +
Sbjct: 357 KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQ-IERLEAQLEKKDQQFKEQE 415
Query: 748 QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ 807
+T + I + ++E+++ L++ K + + E++ E +L+ +Q+
Sbjct: 416 KTMSMLQQDIICKQHHLESLDRLLTESKGEMKK--ENMKKDE----ALKALQNQVSEETI 469
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE----NKELQKKNQILLEENQ 863
+ ++ S I ++ELV L L + EKQL + E KEL+ KN L E ++
Sbjct: 470 KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSE 529
Query: 864 NLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK 923
I +QQ L ++ R E TK + Q+ LE L++ + + ++
Sbjct: 530 QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE 589
Query: 924 EIE------DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
+ E DL+ + ++ R K+ ++Y+ E ++++E ++ K + EN M+
Sbjct: 590 KCESAAHEADLKRQKVIELTGTARQVKIEMDQYK---EELSKMEKEIMHLKRDGENKAMH 646
Query: 978 VEELN------------KMN----LELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+ +L+ K N LE + + + T++ E E+ + LK
Sbjct: 647 LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST 706
Query: 1022 DEEIIALNQKINNAQVSY---MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++ L + AQ+S + + D ++L + ++E+ ++E+ + + L K+ N
Sbjct: 707 LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL---KERN 763
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
EL+ + ++E + E I K EG + S +E + + ++
Sbjct: 764 WELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELE-LKECNKQIESLNDKLQNA 822
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
L+ E+EFI ++ +++ ++L E++ ++ ++E++ E + ++
Sbjct: 823 KEQLR---EKEFIMLQN--EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAID 877
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSA---VDQRGFEIAELWKQHLAQREADFQKTEH 1255
L +L + N + +AE R A +++ E+ ++ KQ +++A
Sbjct: 878 LGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDM-KQLSKEKDAHGNHLAE 936
Query: 1256 EL---RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
EL +V+ + E++ + + + S+ E + ME ++ +N + K + Q+
Sbjct: 937 ELGASKVREAHLEARMQAEIKKL-SAEVESLKEAYHMEMISHQENHAKWKIS--ADSQKS 993
Query: 1313 YADVIN-QIEILRSEIED 1329
+N Q+E + E+E+
Sbjct: 994 SVQQLNEQLEKAKLELEE 1011
Score = 87.8 bits (208), Expect = 3e-16
Identities = 142/787 (18%), Positives = 346/787 (43%), Gaps = 51/787 (6%)
Query: 220 KMQENFIAMEAEWKDEKQRLL-KDIESKDVRISSLEEANKL--LEAARFEISLEHSKLAQ 276
+++ I +EAE D K + + + + ++ LE+A+ LE+ + + L +
Sbjct: 272 ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK 331
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE---IANMTELTKKIELLEH 333
+LE+ L ++ +E + E+ +E + E I E KKI L +H
Sbjct: 332 QLEEKIVAYSSIAAKNAELEQELMEKN-EKIRSLETNINTEHEKICLAFEKAKKIHLEQH 390
Query: 334 --LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWS-QLS 390
+ QI + +LE K + K +S + +I ++ + ++ + ++
Sbjct: 391 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQD---IICKQHHLESLDRLLTESKGEMK 447
Query: 391 SETLNQDTDKKINKNEIAKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTL 448
E + +D K +N++++ + ++ L+ ++ +E V+ K
Sbjct: 448 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 507
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE---LNDEIKDVNVKDLIEKL 505
L+ + ++ SL + + Q+Q+ Q+ N E++D K +EK
Sbjct: 508 EEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK--LEKQ 565
Query: 506 KSAEEQITQLNDEIDAANKNMIKVK---SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
S EQ Q E A ++ K + H+ LK+ QK I+ E+ + E
Sbjct: 566 VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR-QKVIELTGTARQVKIEMDQYKE 624
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
EL + +++ L+ + N +HL D MI ++ + N + K E++
Sbjct: 625 ELSKMEKEIMHLKRDGENKAMHLSQLD---MILDQTKTELEKKTNAVKELEKLQHSTETE 681
Query: 623 KFDLVQELHILQQKYDEVEDKL-ADISQLQSDQVCSEIKSVHLEEQ---IDALSASKKEL 678
+ +Q+ +L+ + +L + + QLQ + + + LEE+ I L+A +E
Sbjct: 682 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC 741
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ IE+ K++L + L+ ++ + +M + + +M +KI +L
Sbjct: 742 KMEIED---KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEME-QKIIKLEGT 797
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ E+S+++ + + +I+ + ++N + +L + + + + E+ I+ ++ +++
Sbjct: 798 L---EKSELELK-ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 853
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
++ S ++E+++ + + +L L + + + +L E H+ + Q++ + L
Sbjct: 854 MKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERL 913
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESE-STKYQTQLRDLESNLKRITHEHQTL 917
E ++++ + H N L E+ + + E+ + Q +++ L + ++ + +
Sbjct: 914 SSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME 973
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
++ ++ +I ++Q +S+++ LNE+ EK + +L+E ++ + NL+
Sbjct: 974 MISHQENHAKWKISADSQ-KSSVQQ---LNEQLEK-------AKLELEEAQDTVSNLHQQ 1022
Query: 978 VEELNKM 984
V++ N++
Sbjct: 1023 VQDRNEV 1029
Score = 82.6 bits (195), Expect = 1e-14
Identities = 195/960 (20%), Positives = 393/960 (40%), Gaps = 89/960 (9%)
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
E+++ + A ++ L + N + + ++L +++ E + KL+ +EN + +KL
Sbjct: 6 EKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 65
Query: 726 KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RD---LYIENIESEL--SKYKSRIC 779
M A K SE++A++ QS ++ + ++ K + RD L EN E ++ + R+
Sbjct: 66 IM-AVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLD 124
Query: 780 RLEESIAVMEDRRYSLERKADQLG---------SYLQEKQKAYSEYTIQEDELV-----N 825
++ I SLE+ QL SYL + Q S ++ +ED + N
Sbjct: 125 LCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQM--SSFSNKEDRCIGCCEAN 182
Query: 826 RLAVLMDHDRVVEKQLLEIE--HENKELQKKNQILLEENQNLQIS-LSDMQQHYNAL--- 879
+L + ++ K+ EI+ H N + +Q L+ N + + S LS ++ L
Sbjct: 183 KLVISELRIKLAIKEA-EIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGH 241
Query: 880 -----VEKANRTDLA---ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
V+ N+ + E E + T + +L + L +I E+ L V ++
Sbjct: 242 QVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLI 301
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
+E A K+ +E +K + +T LE QL+E ++ EL + EL++K
Sbjct: 302 QEELLEKASNSSKLESEMTKKCSQLLT-LEKQLEEKIVAYSSIAAKNAELEQ---ELMEK 357
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
+ ++ +S E IN ++ L +K ++I K Q+ + + E K
Sbjct: 358 N---EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE--AQLEKKDQ 409
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEG 1111
QF + E+ M + + ++ + H E L L+ E ++K KE N+ K E
Sbjct: 410 QF----KEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK--KE-------NMKKDEA 456
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
+ + +S++ V L + + ++ E+ K +E C
Sbjct: 457 L--KALQNQVSEETIKVRQLDSALEICKEELVLHLNQ--LEGNKEKFEKQLKKKSEEVYC 512
Query: 1172 YTKIIQLETLNTELTGH-DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
K ++++ + + T +V+ Q + Q + L+Q N L T +L +S ++Q
Sbjct: 513 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSK-LEQ 571
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME 1290
EL KQ + E +K E + + K +++++ ++ Q + + M+
Sbjct: 572 ------ELQKQRESSAEK-LRKMEEKCESAAHEADLKRQKVIELTGTARQVK----IEMD 620
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXX 1350
Q +K++ + HL+ E A ++Q++++ + + E
Sbjct: 621 QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET 680
Query: 1351 DLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
+L TE +++ E + N + E + + + + +LT +L
Sbjct: 681 EL-TEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELR 739
Query: 1411 LKDSEIYQKTHEYTI---TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMH 1467
EI K E L +RN E + Q+ + I + E E ++ L +
Sbjct: 740 ECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE 799
Query: 1468 ENANHYETMQKESEIERVKLI---EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQT 1524
++ + K+ E KL E+L K + +++++L K +E + EM++
Sbjct: 800 KSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMES 859
Query: 1525 ALENQEIEIVTLNDEITNLQNMVRASSSKIQ-KHVSFASDTKQGRDEQLD-NTMNKELLD 1582
++ QE I T E +L +R + ++Q H A Q Q + ++ EL D
Sbjct: 860 VMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 919
Score = 81.8 bits (193), Expect = 2e-14
Identities = 180/876 (20%), Positives = 368/876 (42%), Gaps = 76/876 (8%)
Query: 498 VKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
V + +EK+++ EE + + + NK + + +K +L+ +++ + + +++ KE
Sbjct: 4 VAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEK 63
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAIS 617
+R+ + S+ +A+L E + ++ + ++ I D + M E L + R+ A
Sbjct: 64 LRIMAVKN--SEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENREL-KVRVAA-- 118
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
++++ DL Q+ ++ E+ ISQL + KS + Q+ + S +
Sbjct: 119 --QNERLDLCQQ--EIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDR 174
Query: 678 LALVIE--NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
E L + + ++ IK+ E K Q + D E +
Sbjct: 175 CIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE 234
Query: 736 LAKI-NHE--EQSKIQTQFGIDAKIQ-ERDLYIENIESELSKYKSRICRLEESIAVMEDR 791
K+ H+ E K Q Q ++ + + ER + IE + ++++ ++E A D
Sbjct: 235 PVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIE----ELRTKLIQIE---AENSDL 287
Query: 792 RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL---EIEHEN 848
+ ++ + Q +E + S + E E+ + + L+ ++ +E++++ I +N
Sbjct: 288 KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKN 347
Query: 849 KELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRD--LESN 906
EL+++ E+ ++L+ +++ + EKA + L + + + Q + + LE
Sbjct: 348 AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 407
Query: 907 LKRITHEHQTL------IVQKKKEIEDL-----EIEFNTQIESAIRDK--KVLNEKYEKN 953
++ + +T+ I+ K+ +E L E + + E+ +D+ K L + +
Sbjct: 408 DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE 467
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
V QL++ L+ K + L++N E NK E +K ++K+ + Y Q E+
Sbjct: 468 TIKVRQLDSALEICKEELV-LHLNQLEGNK---EKFEKQLKKKSEEV--YCLQ--KELKI 519
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE----NMEEEMQRVSK 1069
N L++ E+ + L + Q + + +L TKLE +E+E+Q+ +
Sbjct: 520 KNHSLQETSEQNVILQHTLQQQQ-QMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRE 578
Query: 1070 QLLDS-KQHNEELQILVREQD---DQIKELKET--KLTFEMNIPKTEGMIISSTIEPMSD 1123
+ ++ E+ + E D ++ EL T ++ EM+ K E + I +
Sbjct: 579 SSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR 638
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT 1183
D N K + E++ + L++ TEL E K LET
Sbjct: 639 DGENKAMHLSQLDMILDQTKTELEKKTNAVKE-LEKLQHSTETELTEALQKREVLETELQ 697
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTV----AELRSSISSAVD--QRGFEIAE 1237
G Q+ +L+ L++ + +T+ AELR D Q E+ +
Sbjct: 698 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ 757
Query: 1238 LWKQ---HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE--ETNKIVTMEQV 1292
K+ L QR A + +R E K +L +++ S E E NK Q+
Sbjct: 758 ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK-----QI 812
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
SL +KLQ+ +E LR + +I L+ EIE
Sbjct: 813 ESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE 848
Score = 38.7 bits (86), Expect = 0.17
Identities = 79/454 (17%), Positives = 179/454 (39%), Gaps = 30/454 (6%)
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTE 1209
E +L+E+ +L E K+ + N+E+ +++ I +L+S+LE ++ +
Sbjct: 42 ELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRD 101
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+L++ EL+ +++ ++ E+ + R + ++ L+ +L F+S
Sbjct: 102 KFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLS 161
Query: 1270 QLLDSVQSSTQE------ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKY-ADVINQIEI 1322
+ S S+ ++ E NK+V ++ L+ KL KE ++ L A+ ++Q I
Sbjct: 162 KYQMSSFSNKEDRCIGCCEANKLV----ISELRIKLAIKEAEIQKLHANLTANQLSQSLI 217
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSX 1382
++ ++ ++ +NQ Q + +E +L
Sbjct: 218 TCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYE------KERQRLVTGIE 271
Query: 1383 XXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
+D + + T Q +L E+ +K + + E QL+
Sbjct: 272 ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSS----KLESEMTKKCSQLL 327
Query: 1443 EYEKRIED--LTYEK-ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
EK++E+ + Y ++ A L ++ E +++ E K+ L + + +
Sbjct: 328 TLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC--LAFEKAKKI 385
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
L +Q E+ K +E A+ + + QE + L +I Q+ + + + +
Sbjct: 386 HL-EQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKG 444
Query: 1560 FASDTKQGRDEQLDNTMNKELLDAVPRAELDLAM 1593
+DE L N+ + + +LD A+
Sbjct: 445 EMKKENMKKDEALKALQNQVSEETIKVRQLDSAL 478
>AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein.
Length = 1088
Score = 92.3 bits (219), Expect = 1e-17
Identities = 136/664 (20%), Positives = 283/664 (42%), Gaps = 54/664 (8%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
KEL L+ + L+ + E T K N +++ + KL +Q L + E+ E
Sbjct: 279 KELFLLRKTLE-EMELRIETQKQTLNARDESIKKLLEMLQSK-----GLSAKATEEDHER 332
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIES--ELSKYKSRICRLEESIAVMEDRRY 793
++ E + ++ K +E + E + E + ++ L+ I + + +
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S+ER L +Q + + T + +E + ++ V H + ++ ++ +++ E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ L + + L SD +QH L E E + QT++ L L+ E
Sbjct: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----E 505
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+T++ +K K+I+D+ E TQ I D K + + E+ + + + IEN
Sbjct: 506 KETMLNKKTKQIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIEN 554
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L + + K + + + V+ Q + + T+ + L L +K+ I L ++ +
Sbjct: 555 LQEQLRDKEKQ-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRD 609
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + +Y+ L K+ ++ ++ LLD K+H L ++D ++K
Sbjct: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
Query: 1094 EL-------KETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQ 1145
L KE L E + K + + P MSD +++ K Q
Sbjct: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS--KAQ 727
Query: 1146 EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS--KL 1203
E + + E +L+E + N + ++ Q++ N ++ ++ ++EQ+ + KS L
Sbjct: 728 AEVDRLLE--ILKEVENEKNDKDKKIAELERQVKDQNKKVA--NLKHKEQVEKKKSAQML 783
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSA 1263
E+ DNL + +L+ S+ D R E+ E ++ + Q A+ + + +
Sbjct: 784 EEARRREDNLNDSSQQLQDSLRKK-DDRIEELEEALRESV-QITAEREMVLAQEESARTN 841
Query: 1264 FESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
E + E+LL +++ QE E+ K +++S Q L +KE HL NL+ + + ++
Sbjct: 842 AEKQVEELLMAMEKVKQELESMK----AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 897
Query: 1323 LRSE 1326
++ E
Sbjct: 898 MKQE 901
Score = 80.2 bits (189), Expect = 6e-14
Identities = 170/863 (19%), Positives = 364/863 (42%), Gaps = 84/863 (9%)
Query: 801 QLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDHDRVVEKQLLEIEHENKELQKKN-Q 856
QL L+E + ++E +L +N + + E+ L + E + K+ +
Sbjct: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 216
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKRITHEHQ 915
++ EENQ++Q+++ +Q + N+ +S S + + +L E N +R+ EH+
Sbjct: 217 VVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275
Query: 916 TLIVQK---KKEIEDLEIEFNTQIESA-IRD---KKVLNEKYEKNIEYVTQLE-----AQ 963
+ +K +E++E+ TQ ++ RD KK+L K + E +
Sbjct: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335
Query: 964 LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE----QYINEI--NKLNAL 1017
L E + ++ +L +E+ K N ++ + + ++ +PD + Q + E+ +K++++
Sbjct: 336 LAEAEMHVHHLESLLEQKEKEN-SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394
Query: 1018 ---LKQKDEEII------ALNQKINNAQVSYMSM-----------VSDYESKLAQFTTKL 1057
L+ +EEI AL+ + ++ M + + + +L++ T+L
Sbjct: 395 ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL 454
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
++ +++ ++ Q DSKQH E L+ + ++ + L+ + + + E M+ T
Sbjct: 455 LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT 514
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQ---SAKLNTELQECY 1172
+ + D A L V+E + + ++ + LQEQ K + L+E
Sbjct: 515 -KQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE-R 572
Query: 1173 TKIIQLETLNTEL---TGHDVVNQEQ--INQLKSKLEQLNTEN----DNLLSTVAELRSS 1223
K +Q +T NT+ T + + +++ I +LK + ++ E DN + +L+
Sbjct: 573 VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 632
Query: 1224 ISSAVDQRGFEIAELW--KQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+S + A L K+H + + K + L+ A E K E+ L ++S ++
Sbjct: 633 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL-KMESQLKK 691
Query: 1282 ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK----YADVINQIEILRSEIEDEKVAFXXX 1337
+ + +++Q E + +++ A+V +EIL+ E+E+EK
Sbjct: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK-EVENEK------ 744
Query: 1338 XXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
++ +N+ ++ + + +++AQ+ + + ++ D
Sbjct: 745 -NDKDKKIAELERQVKDQNKKVANLKHKEQVE-KKKSAQMLEEARRREDNLNDSSQQLQD 802
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES 1457
+ K + +LE E Q T E + L Q N +Q+ E +E + E ES
Sbjct: 803 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES 862
Query: 1458 ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE--- 1514
A L ++ ET ER K +EE+ E++ + N AL E
Sbjct: 863 MKAKLS-STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSS 921
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
KT E AL+ ++ +V + T QN ++ + + +S + Q + +
Sbjct: 922 SKKKTQEEVAALKREKDRLVQQLKQQT--QNRMKLMADNYEDDHFKSSHSNQTNHKPSPD 979
Query: 1575 TMNKELLDAVPRAELDLAMYMLH 1597
+ + LL+ + + L +Y+ H
Sbjct: 980 QIIQPLLE-LDQNRSKLKLYIGH 1001
Score = 79.0 bits (186), Expect = 1e-13
Identities = 128/621 (20%), Positives = 280/621 (45%), Gaps = 72/621 (11%)
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID-NFSKVSDS 553
+++V L L+ E++ + L +E+ +N + K K +Q I+ SK+S
Sbjct: 340 EMHVHHLESLLEQKEKENSMLREEMHRRFEN-----APDSAKTKALQTVIEMKDSKISSM 394
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL 613
+ + L EE+ L A EE+ + Y S + ++ + + +T L
Sbjct: 395 ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL 454
Query: 614 KAISL----LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
A+ L +Q D Q + +L++ E + A I Q + D + + LEE+
Sbjct: 455 LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA-ILQTEVDAL-----RLRLEEKET 508
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMS 728
L+ K++ + E +++ +KD+ + KE +N LQ I+ + L DK ++MS
Sbjct: 509 MLNKKTKQIQDMAEEKGTQAGEIHD-LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 567
Query: 729 A--EKISELLAKINHE-------EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
+ E++ L A + E++ + + I+ ++RD + E+ YK +
Sbjct: 568 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 627
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
L+E +++++ E++A L L+E + + +++D + L + ++ + +
Sbjct: 628 DLKEKVSLLQGDLS--EKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKK---E 680
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+ L++E +L+K ++ LE + + +SD QH + + + ES+K Q +
Sbjct: 681 ECLKME---SQLKKAHEAALEARASPE--MSDRIQHLEREITRY------KDESSKAQAE 729
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+ L LK + +E K K+I +LE + Q +KKV N K+++ +E
Sbjct: 730 VDRLLEILKEVENEKN----DKDKKIAELERQVKDQ------NKKVANLKHKEQVEKKKS 779
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
+ L+E + +NLN + ++L +L D +++ E+ + E ++ A
Sbjct: 780 AQ-MLEEARRREDNLNDSSQQLQD-SLRKKDDRIEE--------LEEALRESVQITA--- 826
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
+ E++ ++ +A+ + V + + + +LE+M+ ++ + L + + H
Sbjct: 827 --EREMVLAQEE--SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLT 882
Query: 1080 ELQILVREQDDQIKELKETKL 1100
L+ R+ +++ E+K+ L
Sbjct: 883 NLRAERRKHLEEVLEMKQEAL 903
Score = 62.1 bits (144), Expect = 2e-08
Identities = 111/524 (21%), Positives = 233/524 (44%), Gaps = 64/524 (12%)
Query: 524 KNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQL 583
K + K L L+ +T+ N + SDS + I L E L Q+ A L+ E L+L
Sbjct: 444 KQELSRKDTELLALQTKLETLTN--QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL 501
Query: 584 HLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
L + ++ M+ K++ +M T+ I L+ +++++LQ+K + ++++
Sbjct: 502 RLEEKET--MLNKKT-KQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 558
Query: 644 LAD-----------ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L D + LQ+D ++ LEE AL+ ++ + + E D+ +
Sbjct: 559 LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE---ALAEKERTIERLKEQRDRDEREK 615
Query: 693 YGTIKDLENDKEDIMNK---LQNYIQEN----MDLTDK--------LEKMSAEKISELLA 737
I + + D +D+ K LQ + E +DL + L+K S K E+
Sbjct: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Query: 738 KINHEEQSKIQTQF------GIDAKIQ-ERDLYIENIESELSKYK-------SRICRLEE 783
+ EE K+++Q ++A+ E I+++E E+++YK + + RL E
Sbjct: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE 735
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ +E+ + ++K +L ++++ K + +E + A +++ R E L +
Sbjct: 736 ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLND 795
Query: 844 IEHENKE-LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL-- 900
+ ++ L+KK+ + E + L+ S+ + L ++ + AE + + +
Sbjct: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK 855
Query: 901 --RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
++LES +++ Q+L +K+ + +L E +E +VL K E + ++
Sbjct: 856 VKQELESMKAKLSSTQQSL-AEKETHLTNLRAERRKHLE------EVLEMKQEALLAAIS 908
Query: 959 QLEAQ--LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS 1000
+ +A L E ++ + V L + L+ + KQQTQ+
Sbjct: 909 EKDANIALLELSSSKKKTQEEVAALKREKDRLVQQ--LKQQTQN 950
Score = 45.2 bits (102), Expect = 0.002
Identities = 95/552 (17%), Positives = 219/552 (39%), Gaps = 35/552 (6%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 442 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 498
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 499 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
Query: 171 TILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA 230
+ D +++++ + +++ TT + ++ + +++E E
Sbjct: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA----EKERTIERLKEQRDRDER 613
Query: 231 EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXX 290
E ++E KD++ ++S L+ EA+ ++ S LA +
Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 673
Query: 291 XXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLA 350
++ ++ E + + + +LE E++ +I+ LE + + + + + ++
Sbjct: 674 ALEQKKEECLK--MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 731
Query: 351 TMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKL 410
+ K V + I+ ++K ++++ + +KK + + +
Sbjct: 732 RLLEILKEVENEKNDKDKKIA-----ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 786
Query: 411 EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+LN + + +KD ++ L +Q+ ++ M T
Sbjct: 787 RRREDNLNDSSQQLQDSLRKKDDRIEEL------EEALRESVQITAEREMVLAQEESART 840
Query: 471 NTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
N E V E+ E++KQEL E + + L E +T L E K++ +V
Sbjct: 841 NAEKQVEELLMAMEKVKQEL--ESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEV 895
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
L++KQ + + S+ D+N ++ L+ ++VA L+ EK L L
Sbjct: 896 -----LEMKQ-EALLAAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 948
Query: 590 SGRM-IESDVYK 600
RM + +D Y+
Sbjct: 949 QNRMKLMADNYE 960
Score = 36.3 bits (80), Expect = 0.91
Identities = 53/262 (20%), Positives = 106/262 (40%), Gaps = 17/262 (6%)
Query: 1355 ENQSYKQMQEQSILNINEENAQ-LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
+ S + E + + EEN Q L + + E ++ L +D
Sbjct: 247 QQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 1414 SEI---YQKTHEYTITLTQRNDEFENVRQQLVEYEKRI---EDLTYEKESELAILRLKMH 1467
I + ++ ++ E R+ L E E + E L +KE E ++LR +MH
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 1468 ---ENA-NHYETMQKESEIE----RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
ENA + +T ++ IE ++ +E + E + + K L+ EE K
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 1520 NEMQTALEN-QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
E+ + + +I + E++ + A +K++ + SD+KQ + ++ K
Sbjct: 426 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 485
Query: 1579 ELLDAVPRAELDLAMYMLHQRD 1600
E A+ + E+D L +++
Sbjct: 486 EQRAAILQTEVDALRLRLEEKE 507
>U29343-1|AAC52049.1| 725|Homo sapiens hyaluronan receptor protein.
Length = 725
Score = 91.9 bits (218), Expect = 2e-17
Identities = 136/627 (21%), Positives = 262/627 (41%), Gaps = 55/627 (8%)
Query: 726 KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
K ++K + L + E + +Q + D +IQ+ + +E +E+ L+ L +
Sbjct: 75 KKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANN 134
Query: 786 AVMEDRRYSLERKADQLGSYLQEK--QKAYSEYTIQEDELVNR----LAVLMDHDRVVEK 839
A +E + L R + L S E QK +++ +L N+ + +M +E
Sbjct: 135 ATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 194
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+L + +E Q K L + +++ D + L+E A + KY+
Sbjct: 195 KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLD 254
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYE---KNIE 955
+ LE NLK E I+ K+ +ED + + Q+E ++ + + EK + +N E
Sbjct: 255 IAQLEENLKEKNDE----ILSLKQSLEDNIVILSKQVEDLNVKCQLLETEKEDHVNRNRE 310
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP-------DYTEQYI 1008
+ L A++Q + E+L + L+ ID +Q+++ S + E+ +
Sbjct: 311 HNENLNAEMQNLEQKFILEQREHEKLQQKELQ-IDSLLQQEKELSSSLHQKLCSFQEEMV 369
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
E N LKQ +E+ L QK A+ +V E + +L+ +EE+++
Sbjct: 370 KEKNLFEEELKQTLDELDKLQQKEEQAE----RLVKQLEEEAKSRAEELKLLEEKLKGKE 425
Query: 1069 KQLLDSKQHNEELQILVREQ-DDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
+L S + + +L++E+ D ++ L++ FE T I +E S
Sbjct: 426 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 485
Query: 1128 VDXXXXXXXXXXXXLKVQ-EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
L + +E+++ LQ +SA TE++E +Q T
Sbjct: 486 AKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT------ 539
Query: 1187 GHDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
D+ NQ +Q + +LE +T AEL I+ W+ L
Sbjct: 540 --DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK------------WR--LL 583
Query: 1245 QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
E + KT+ ++QL AFE + + LL+ + QE+ NKI L+ K +
Sbjct: 584 YEEL-YNKTK-PFQLQLDAFEVEKQALLNE-HGAAQEQLNKIRDSYAKLLGHQNLKQKIK 640
Query: 1305 HLRNLQEKYADVINQIEILRSEIEDEK 1331
H+ L+++ + + +++ LR ++ +K
Sbjct: 641 HVVKLKDENSQLKSEVSKLRCQLAKKK 667
Score = 83.8 bits (198), Expect = 5e-15
Identities = 144/686 (20%), Positives = 297/686 (43%), Gaps = 67/686 (9%)
Query: 920 QKKKEIEDLEIEFNTQIESAIR-----DKKVLNEKYEKNIEYVT-QLEAQLQEYKNNIEN 973
Q+K+ ++L ++ +T + ++ R + K ++K +K+++ + ++ LQE
Sbjct: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRR 105
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQKDEEIIALNQK- 1031
+ EL KM L +K + + T E+ + E+ + N LLK K E NQK
Sbjct: 106 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE--NGNQKN 163
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ-ILVREQDD 1090
+ + M + + E+K+ K E ME ++Q + L +S+ +L+ LV + +
Sbjct: 164 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 223
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+I E ET+ E IE +S ++ V+ LK ++ +E
Sbjct: 224 KIDEKSETEKLLEY-------------IEEISCASDQVEKYKLDIAQLEENLK-EKNDEI 269
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEN 1210
+ + L++ L+ ++++ K LET + + + E +N LEQ
Sbjct: 270 LSLKQSLEDNIVILSKQVEDLNVKCQLLETEKEDHVNRNREHNENLNAEMQNLEQKFILE 329
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
+ + I S + Q EL L Q+ FQ+ E+ + + FE + +Q
Sbjct: 330 QREHEKLQQKELQIDSLLQQE----KEL-SSSLHQKLCSFQE---EMVKEKNLFEEELKQ 381
Query: 1271 LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
LD + Q+E ++Q L+ + + + E L+ L+EK + E+ +S
Sbjct: 382 TLDELDKLQQKEEQAERLVKQ---LEEEAKSRAEELKLLEEKLKG--KEAELEKSSAAHT 436
Query: 1331 KVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXX 1390
+ D+ + +SYK + I ++ EN+ L++ +
Sbjct: 437 QATLLLQEKYDSMVQSLE--DVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 494
Query: 1391 XXXRVNDAEAK-------VLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN-VRQQLV 1442
++ E+ +L+L + LK++EI E T++ Q+ + +N ++QQ
Sbjct: 495 VQHQILATESSNQEYVRMLLDLQTKSALKETEI----KEITVSFLQKITDLQNQLKQQEE 550
Query: 1443 EYEKRIED---LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
++ K++ED EKE+ A L ++++ YE + +++ +++L ++ +
Sbjct: 551 DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA---FEVEKQA 607
Query: 1500 SLNKQVA---ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
LN+ A +LNK + + AK Q L+ + +V L DE + L++ V SK++
Sbjct: 608 LLNEHGAAQEQLNK-IRDSYAKLLGHQN-LKQKIKHVVKLKDENSQLKSEV----SKLRC 661
Query: 1557 HVSFASDTKQGRDEQLDNTMNKELLD 1582
++ ++ E+L+ + + D
Sbjct: 662 QLAKKKQSETKLQEELNKVLGIKHFD 687
Score = 50.8 bits (116), Expect = 4e-05
Identities = 136/697 (19%), Positives = 282/697 (40%), Gaps = 66/697 (9%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
+E K E Q+ KD++ + I L + + ++ E K+ L
Sbjct: 72 SESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLS 131
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L KQ IE + E+ + E N L +I LE + + ++ K
Sbjct: 132 ANNATLEKQLIELT--RTNELLKSKFSENGNQKNL--RILSLELMKLRNKRETKMRGMMA 187
Query: 350 ATMGTESKA-VSSPSKKGSP-LISRKSGRNTASKMKSPWSQLSSETLNQDTDK-KINKNE 406
G E K V+ S + S I++ G+ + + + + +E L + ++ ++
Sbjct: 188 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 247
Query: 407 IAKLEMVIQSLNKDLVDK-EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
+ K ++ I L ++L +K + ++S K + + L + QL +E
Sbjct: 248 VEKYKLDIAQLEENLKEKNDEILSLKQSLEDNIVILSKQVEDLNVKCQL-----LETEKE 302
Query: 466 IHVGTNTEDVNEIAKVQEQLKQEL---NDEIKDVNVKDL-IEKLKSAEEQITQ-LNDEID 520
HV N E + + L+Q+ E + + K+L I+ L E++++ L+ ++
Sbjct: 303 DHVNRNREHNENLNAEMQNLEQKFILEQREHEKLQQKELQIDSLLQQEKELSSSLHQKLC 362
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
+ + M+K K+ + +LKQ D K+ ++ RL V +LEEE +
Sbjct: 363 SFQEEMVKEKNLFEEELKQTL---DELDKLQQKEEQAERL----------VKQLEEEAKS 409
Query: 581 LQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
L +++E + K E+E + +A LL+ + +VQ L + +++
Sbjct: 410 RAEEL------KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 463
Query: 639 ------EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
E+ED + S LQ + + ++ QI A +S +E ++ +L Q
Sbjct: 464 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL-----QT 518
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
+K+ E I +++Q+ DL ++L K E + L + K T
Sbjct: 519 KSALKETE-----IKEITVSFLQKITDLQNQL-KQQEEDFRKQLEDEEGRKAEKENTTAE 572
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLE-ESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ +I + L E + ++ ++ ++ E E A++ + + E QL K
Sbjct: 573 LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE----QLNKIRDSYAK 628
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE-NKELQKKNQILLEENQNLQISLS 870
+++ + + L D + ++ ++ ++ + K+ Q + ++ E N+ L I
Sbjct: 629 LLGHQNLKQK--IKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 686
Query: 871 DMQQ--HYNALVEKANRTDLAESESTKYQTQLRDLES 905
D + H+ + A +T L E + Y+ + ES
Sbjct: 687 DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQES 723
Score = 45.6 bits (103), Expect = 0.001
Identities = 77/460 (16%), Positives = 185/460 (40%), Gaps = 20/460 (4%)
Query: 1142 LKVQEEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
LK+ E+E +QER + L TEL++ ++ T L+ ++ ++Q+ +L
Sbjct: 85 LKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 144
Query: 1200 KSKLEQLNT---ENDNLLSTVAELRSSISSAVDQRGFEIAELW-KQHLAQREADF-QKTE 1254
E L + EN N + L + ++R ++ + KQ + + Q++
Sbjct: 145 TRTNELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 203
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT-MEQVTSLQNKLQDKEEHLRNLQEKY 1313
E + +++ E K + + + + ET K++ +E+++ ++++ + + L+E
Sbjct: 204 EESQGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 262
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ ++I L+ +ED V L TE + + + N+N E
Sbjct: 263 KEKNDEILSLKQSLEDNIVILSKQVEDLNVKCQL----LETEKEDHVNRNREHNENLNAE 318
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
L++ ++ E ++ L Q + S ++QK + + + +
Sbjct: 319 MQNLEQK----FILEQREHEKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNL 374
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
FE +Q ++ +++ + E + L + A + ++++ + + +L +
Sbjct: 375 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 434
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL-NDEITNLQNMVRASSS 1552
++ L ++ + ++LE+ A+ E AL EIE + L N + ++
Sbjct: 435 HTQATLLLQEKYDSMVQSLEDVTAQF-ESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 493
Query: 1553 KIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+Q + + Q L + K L E+ ++
Sbjct: 494 DVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVS 533
>BX538186-1|CAD98058.1| 971|Homo sapiens hypothetical protein
protein.
Length = 971
Score = 91.9 bits (218), Expect = 2e-17
Identities = 174/822 (21%), Positives = 342/822 (41%), Gaps = 80/822 (9%)
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---ERDLYIENIESE 770
+ + + ++L +M E ++++L ++ E + I+ G K Q ER+L S+
Sbjct: 92 VNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK-RSQ 150
Query: 771 LSKYKSRICRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
L +S E+ + ++ + L + +L + LQ Q + +L L
Sbjct: 151 LFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTAL 210
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A+ ++ +V++KQL + + L K++ E L + +QQ + LV KA+
Sbjct: 211 AIAENNVQVLQKQLDDAKEGEMALLSKHK---EVESELAAARERLQQQASDLVLKASHIG 267
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
+ ++ + ++DLES R+ L E E + TQ + +++L
Sbjct: 268 MLQATQMTQEVTIKDLESEKSRVNERLSQL------EEERAFLRSKTQSLDEEQKQQILE 321
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
+ + N TQ E +E KN L V +LN+ + + +++ K
Sbjct: 322 LEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNA 381
Query: 1008 INEINKLNA-LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
I + KL L +Q +++ + L + N Q ++ E KL ++ ++++ M R
Sbjct: 382 IRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLDTANQEIGHLQD-MVR 440
Query: 1067 VSKQ-------LLDSKQHNEE-LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTI 1118
S+Q L+ S Q ++E LQ + D +KE K+ L E + + E TI
Sbjct: 441 KSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETI 499
Query: 1119 EPMSDDAN-NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE-LQECYTKII 1176
M ++ VD L+++ E QE S L+E+ + E + ++++
Sbjct: 500 AAMKEEEKLKVDKMAHD-------LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLL 552
Query: 1177 QLETL--NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
QL+ N ++ +NQ+ + L + +++ +L++ + + E
Sbjct: 553 QLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 612
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTS 1294
+ EL +QH Q+ K H L Q E + EQ ++++ Q++ + ++ S
Sbjct: 613 LEELEEQH--QQRHKSLKEAHVLAFQTMEEEKEKEQR--ALENHLQQKHSA-----ELQS 663
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRT 1354
L++ ++ E LR E+ +++ LR E+EDE A DL
Sbjct: 664 LKDAHRESMEGLRIEMEQ------ELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLR 717
Query: 1355 ENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDS 1414
N QE + + +L++S R+ D + ++ H++ D
Sbjct: 718 HNHH----QELAAAKM-----ELERSIDISRRQSKEHICRITDLQEELRHREHRISELDK 768
Query: 1415 EIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYE 1474
E+ Q HE LT+ +E++ + E L ES I +M E +
Sbjct: 769 EV-QHLHENISALTKE-----------LEFKGK-EILRIRSESNQQIRLEEMEE-----K 810
Query: 1475 TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEV 1516
+ +ES+ E +++I EL +TE + K++ E NK + E+
Sbjct: 811 YLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLEL 852
Score = 70.9 bits (166), Expect = 3e-11
Identities = 158/806 (19%), Positives = 340/806 (42%), Gaps = 66/806 (8%)
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN--LAETRLKAISLLESQKFDLVQEL 630
E++E + Q H + G+ ++++ +E N L E RL+ L+E + L +
Sbjct: 77 EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ 136
Query: 631 HILQQKYDEVEDK---LADISQLQSDQVCSEIKSVHLEEQI--DALSASKKELALVIENL 685
+++ D ++ A+ Q ++ K +E I + K EL +V +
Sbjct: 137 SFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEA 196
Query: 686 K--LDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
LDK ++L + EN+ + + +L + + M L K +++ +E ++ ++ +
Sbjct: 197 GSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESE-LAAARERLQQQ 255
Query: 743 EQSKI--QTQFG-IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
+ + G + A +++ I+++ESE S+ R+ +LEE A + + SL+ +
Sbjct: 256 ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ 315
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQIL 858
Q L+ ++K Q++ L L QL E + +EL K+ +
Sbjct: 316 KQ--QILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMA 373
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+E + ++ D ++ L E+ N+ D E K Q Q ++LE NLK + +
Sbjct: 374 IEAVHS--NAIRDKKKLQMDLEEQHNK-DKLNLEEDKNQLQ-QELE-NLKEVLEDKLDTA 428
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
Q+ ++D+ + + SA L + E+ + + L+E K+ + N+ +
Sbjct: 429 NQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGEL 488
Query: 979 EELNKMNLELI----DKHVQKQQTQSPD----YTEQYINEINKLNALLKQKDEE------ 1024
E+ + + E I ++ K + D +TE E +KL L+ + EE
Sbjct: 489 EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAM 548
Query: 1025 --IIALNQKINN-AQVSYMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQH 1077
++ L + N A+ S+ V D ++++ LE + +Q++ Q +Q
Sbjct: 549 SQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQR 608
Query: 1078 -NEELQILVREQDDQIKELKETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+EL+ L + + K LKE L F+ + E + + +
Sbjct: 609 LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH 668
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ 1195
L+++ E+E R L+++ + L+ +++ +L H+ + ++
Sbjct: 669 RESMEGLRIEMEQELQTLRFELEDEGKAMLASLR---SELNHQHAAAIDLLRHN--HHQE 723
Query: 1196 INQLKSKLEQ-LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQ------R 1246
+ K +LE+ ++ + + + + + R I+EL K QHL + +
Sbjct: 724 LAAAKMELERSIDISRRQSKEHICRI-TDLQEELRHREHRISELDKEVQHLHENISALTK 782
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
E +F K + LR++ ES + L+ ++ +K ++ +T L+ L ++++ +
Sbjct: 783 ELEF-KGKEILRIR---SESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQII 838
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKV 1332
+ L E + Q+E++ E KV
Sbjct: 839 KKLIED--NKFYQLELVNRETNFNKV 862
Score = 67.7 bits (158), Expect = 3e-10
Identities = 143/762 (18%), Positives = 328/762 (43%), Gaps = 83/762 (10%)
Query: 461 EGPSLIHVGTNTEDVNEIA-KVQEQLKQELNDEIKDVNVKDL-IEKLKSA-----EEQIT 513
E + + T + +V EI K +E+L+ +++ K L +E L++A +E +
Sbjct: 24 EAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLK 83
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKV-- 571
D + NK K + H+++++ + K ++ ++ K+++ E + +Q
Sbjct: 84 SQQDHSASVNKGQEKAEELHRMEVESLNKMLE---ELRLERKKLIEDYEGKLNKAQSFYE 140
Query: 572 AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAET---RLKA-ISLLESQKFDLV 627
EL+ K + + + E+D+ K+ E + +LK + +++ + L+
Sbjct: 141 RELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLL 200
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA-LSASKKELALVIENLK 686
+ LQ E+ + + + D E+ + +++++ L+A+++ L +L
Sbjct: 201 DKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLV 260
Query: 687 LDKEQL----------YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
L + TIKDLE++K + +L +E L K + + E+ ++L
Sbjct: 261 LKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQIL 320
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA-VMEDRRYSL 795
E + K+ +AK +++ Y +++ S+ + + +L E+ + +E+ +
Sbjct: 321 -----ELEKKVN-----EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKH 370
Query: 796 ERKADQLGS-YLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE-----KQLLE--IEHE 847
+ + S +++K+K + ++E ++L + D +++ + K++LE ++
Sbjct: 371 HMAIEAVHSNAIRDKKKL--QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLDTA 428
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
N+E+ ++ + Q L + + ++ N DL + + + L ++E L
Sbjct: 429 NQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGEL 488
Query: 908 KRITHEHQTLIVQKKKE--------IEDLEIEFNTQIE---SAIRDKKVLNEKYEKN--I 954
++ +H+ I K+E DLEI++ + S +R++ L + +K +
Sbjct: 489 EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAM 548
Query: 955 EYVTQLE-----AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+ QL+ A ++ +E+L +N L K NLE+ + + QT Q+
Sbjct: 549 SQLLQLKDREKNAARDSWQKKVEDL-LNQISLLKQNLEI---QLSQSQTSLQQLQAQFTQ 604
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQV-SYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
E +L L++ +E+ ++ + A V ++ +M + E + LEN ++
Sbjct: 605 ERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKE----QRALENHLQQKHSAE 660
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV 1128
Q L H E ++ L E + +++ L+ FE+ + + M+ S E A +
Sbjct: 661 LQSL-KDAHRESMEGLRIEMEQELQTLR-----FELE-DEGKAMLASLRSELNHQHAAAI 713
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
D K++ E R +E ++ T+LQE
Sbjct: 714 DLLRHNHHQELAAAKMELERSIDISRRQSKEHICRI-TDLQE 754
Score = 48.0 bits (109), Expect = 3e-04
Identities = 96/444 (21%), Positives = 182/444 (40%), Gaps = 51/444 (11%)
Query: 1158 QEQSAKLNTELQECYT-KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
Q+ SA +N ++ +++E+LN L + ++ I + KL + + + L T
Sbjct: 86 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 145
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
+ + + ++ + A+L K+ Q EA +KT +L+ +L + + LLD Q
Sbjct: 146 LKRSQLFTAESLQASKEKEADLRKEFQGQ-EAILRKTIGKLKTELQMVQDEAGSLLDKCQ 204
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
+T + V LQ +L D +E L K+ E+E E A
Sbjct: 205 KL---QTALAIAENNVQVLQKQLDDAKEGEMALLSKH-----------KEVESELAAARE 250
Query: 1337 XXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+ Q+ + QE +I ++ E + RVN
Sbjct: 251 RLQQQASDLVLKASHIGML-QATQMTQEVTIKDLESEKS------------------RVN 291
Query: 1397 DAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE 1456
+ +++ E L K + ++ + + L ++ +E + +Q+ YE+ +++L E
Sbjct: 292 ERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEY--YERELKNLQSRLE 349
Query: 1457 SELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEV 1516
E+ L + H + IE V + K + L +Q + LEE+
Sbjct: 350 EEVTQLN-EAHSKTLEELAWKHHMAIEAVHS-NAIRDKKKLQMDLEEQHNKDKLNLEED- 406
Query: 1517 AKTNEMQTALENQ----EIEIVTLNDEITNLQNMVRASSSKI---QKHVSFASDTKQGRD 1569
N++Q LEN E ++ T N EI +LQ+MVR S + + ++ D+++
Sbjct: 407 --KNQLQQELENLKEVLEDKLDTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 464
Query: 1570 EQLDNTMN--KELLDAVPRAELDL 1591
+LD T + KE DA+ E +L
Sbjct: 465 NELDLTKDSLKETKDALLNVEGEL 488
Score = 39.5 bits (88), Expect = 0.098
Identities = 33/165 (20%), Positives = 70/165 (42%), Gaps = 4/165 (2%)
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
L+ H+ E+++ Q+ H ++ Q E E R ++ K +E+L E++ +
Sbjct: 70 LQAAHRREIQELLKSQQDHSASVNKGQEKAE-ELHRMEVESLNKMLEELRLERKKLIEDY 128
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
K+++ + YE + ++ E L + L K+ L + + K +
Sbjct: 129 EGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGK---L 185
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQG 1567
+T L+ + E +L D+ LQ + + + +Q D K+G
Sbjct: 186 KTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEG 230
Score = 34.7 bits (76), Expect = 2.8
Identities = 90/519 (17%), Positives = 209/519 (40%), Gaps = 40/519 (7%)
Query: 162 QVKMKIMETTILDLQEKINEK-DQIIEAKNKATTXXX-XXXXXXXXXXXXXXEDTKQQMT 219
+ + + E + +LQ ++ E+ Q+ EA +K D K+
Sbjct: 331 RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
Query: 220 KMQENFIAMEAEWKDEKQRLLKDIES-KDVRISSLEEANKLLEAARFEISLEHSKL--AQ 276
++E + +++K +L +++E+ K+V L+ AN+ + + + L A+
Sbjct: 391 DLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLDTANQEIGHLQDMVRKSEQGLGSAE 450
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE-------IANMTELTK-KI 328
L L K S++ + + +E + E IA M E K K+
Sbjct: 451 GLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 510
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKG--SPLISRKSGRNTASKMKSPW 386
+ + H + +I+ T + L + + + E + KK S L+ K A++ W
Sbjct: 511 DKMAH-DLEIKWT-ENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAAR--DSW 566
Query: 387 SQLSSETLNQDTDKKINKN-EIAKLEMVIQSLNKDLVDKEYVISEK--DTXXXXXXXXXX 443
+ + LNQ + K N ++++ + +Q L + ++++ +
Sbjct: 567 QKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKS 626
Query: 444 GKDTLIAQLQ-LEHQQHMEGPSLI-HVGT-NTEDVNEIAKVQEQLKQELNDEIKDVNVKD 500
K+ + Q +E ++ E +L H+ ++ ++ + + + L E++
Sbjct: 627 LKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGLRIEMEQELQTL 686
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKV-KSNHKLKLKQMQKTIDNFSKVS--DSNKEI 557
E + + L E++ + I + + NH +L + ++ +S S + I
Sbjct: 687 RFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHI 746
Query: 558 VRLT---EELHHLSQKVAELEEEKGNLQLHL------VDYDSGRMIE-SDVYKKMIEMEN 607
R+T EEL H +++EL++E +L ++ +++ ++ + I +E
Sbjct: 747 CRITDLQEELRHREHRISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEE 806
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD 646
+ E L S + + ++ EL + + D++ KL +
Sbjct: 807 MEEKYLMRES--KPEDIQMITELKAMLTERDQIIKKLIE 843
>AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein.
Length = 992
Score = 91.9 bits (218), Expect = 2e-17
Identities = 134/666 (20%), Positives = 282/666 (42%), Gaps = 54/666 (8%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
KEL L+ + L+ + E T K N +++ + KL +Q L + E+ E
Sbjct: 279 KELFLLRKTLE-EMELRIETQKQTLNARDESIKKLLEMLQSK-----GLSAKATEEDHER 332
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIES--ELSKYKSRICRLEESIAVMEDRRY 793
++ E + ++ K +E + E + E + ++ L+ I + + +
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S+ER L +Q + + T + +E + ++ V H + ++ ++ +++ E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ L + + L SD +QH L E E + QT++ L L+ E
Sbjct: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----E 505
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+T++ +K K+I+D+ E TQ I D K + + E+ + + + IEN
Sbjct: 506 KETMLNKKTKQIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIEN 554
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L + + K + + + V+ Q + + T+ + L L +K+ I L ++ +
Sbjct: 555 LQEQLRDKEKQ-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRD 609
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + +Y+ L K+ ++ ++ LLD K+H L ++D ++K
Sbjct: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
Query: 1094 EL-------KETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQ 1145
L KE L E + K + + P MSD +++ + +
Sbjct: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 729
Query: 1146 EEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS-- 1201
+ E ++E + K EL+ ++ Q++ N ++ ++ ++EQ+ + KS
Sbjct: 730 VDRLLEILKEVENEKNDKDKKIAELESLTSR--QVKDQNKKVA--NLKHKEQVEKKKSAQ 785
Query: 1202 KLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQL 1261
LE+ DNL + +L+ S+ D R E+ E ++ + Q A+ + +
Sbjct: 786 MLEEARRREDNLNDSSQQLQDSLRKK-DDRIEELEEALRESV-QITAEREMVLAQEESAR 843
Query: 1262 SAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ E + E+LL +++ QE E+ K +++S Q L +KE HL NL+ + + ++
Sbjct: 844 TNAEKQVEELLMAMEKVKQELESMK----AKLSSTQQSLAEKETHLTNLRAERRKHLEEV 899
Query: 1321 EILRSE 1326
++ E
Sbjct: 900 LEMKQE 905
Score = 77.4 bits (182), Expect = 4e-13
Identities = 122/623 (19%), Positives = 268/623 (43%), Gaps = 62/623 (9%)
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ--KTIDNF--SKVS 551
+ +KD K+ S E + L +EI N + ++KQM+ ++ F +K+
Sbjct: 384 IEMKD--SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIG 441
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL--------VDYDSGRMIESDV---YK 600
+E+ R EL L K+ L + + + H+ +++++V
Sbjct: 442 QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL 501
Query: 601 KMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL----ADISQLQSDQVC 656
++ E E + + K I + +K E+H L+ D E K+ I LQ
Sbjct: 502 RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 561
Query: 657 SEIKSVHLEEQIDALSA--SKKELAL-VIENLKLDKEQLYGTIKD-LENDKEDIMNKLQN 712
E + L+E++ +L A + + AL +E +KE+ +K+ + D+ + ++ N
Sbjct: 562 KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN 621
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI--DAKIQERDLYIENIESE 770
Y ++ DL +K+ + + + + ++ +E + G+ D++++ ++ +E + E
Sbjct: 622 YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 681
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
K +S++ + E A +E R + ++ +Q ++ + Y +DE A
Sbjct: 682 CLKMESQLKKAHE--AALE------ARASPEMSDRIQHLEREITRY---KDESSKAQA-- 728
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+ DR++E L E+E+E + KK + E ++L + ++ + ++ + +
Sbjct: 729 -EVDRLLE-ILKEVENEKNDKDKK----IAELESL--TSRQVKDQNKKVANLKHKEQVEK 780
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+S + + R E NL + + Q + +K IE+LE ++ + VL ++
Sbjct: 781 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE 840
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
T E Q++E +E + +E + K L + + +++T T
Sbjct: 841 SAR----TNAEKQVEELLMAMEKVKQELESM-KAKLSSTQQSLAEKETH---LTNLRAER 892
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
L +L+ K E ++A + +A ++ + + S K Q ++ ++ E R+ +Q
Sbjct: 893 RKHLEEVLEMKQEALLAAISE-KDANIALLELSS--SKKKTQ--EEVAALKREKDRLVQQ 947
Query: 1071 LLDSKQHNEELQILVREQDDQIK 1093
L Q+ +L + +DD K
Sbjct: 948 LKQQTQNRMKL-MADNYEDDHFK 969
Score = 71.3 bits (167), Expect = 3e-11
Identities = 112/559 (20%), Positives = 238/559 (42%), Gaps = 51/559 (9%)
Query: 376 RNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
+N ++K S+ +E L T + N+ + + I+ L + L KE + T
Sbjct: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 496
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K+T++ + + Q E GT +++++ + + ++++N +
Sbjct: 497 DALRLRLEEKETMLNKKTKQIQDMAE-----EKGTQAGEIHDLKDMLDVKERKVN--VLQ 549
Query: 496 VNVKDLIEKLKSAEEQITQLNDEI---DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+++L E+L+ E+Q++ L + + A N + + L + ++TI+ + D
Sbjct: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR 612
++ EE+ + + + +L+E+ LQ L + ++ + + + ++R
Sbjct: 610 RDER--EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSR 667
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
LK + + QK + ++ +K E A + S ++ I+ HLE +I +
Sbjct: 668 LKTLEIALEQKKEECLKMESQLKKAHE-----AALEARASPEMSDRIQ--HLEREI---T 717
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKI 732
K E + + + ++L +K++EN+K D K I E LT + K +K+
Sbjct: 718 RYKDESS----KAQAEVDRLLEILKEVENEKNDKDKK----IAELESLTSRQVKDQNKKV 769
Query: 733 SELLAKINHEEQSKIQTQFGIDAKIQERDLY--IENIESELSKYKSRICRLEESIAVMED 790
+ L K + + K Q +A+ +E +L + ++ L K RI LEE A+ E
Sbjct: 770 ANL--KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEE--ALRES 825
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ + ER+ L +++ A + Q +EL+ +EK E+E +
Sbjct: 826 VQITAEREM-----VLAQEESARTNAEKQVEELL----------MAMEKVKQELESMKAK 870
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
L Q L E+ +L ++ ++H ++E LA L +L S+ K+
Sbjct: 871 LSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 930
Query: 911 THEHQTLIVQKKKEIEDLE 929
E L +K + ++ L+
Sbjct: 931 QEEVAALKREKDRLVQQLK 949
Score = 69.7 bits (163), Expect = 8e-11
Identities = 160/834 (19%), Positives = 340/834 (40%), Gaps = 81/834 (9%)
Query: 801 QLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDHDRVVEKQLLEIEHENKELQKKN-Q 856
QL L+E + ++E +L +N + + E+ L + E + K+ +
Sbjct: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 216
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKRITHEHQ 915
++ EENQ++Q+++ +Q + N+ +S S + + +L E N +R+ EH+
Sbjct: 217 VVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275
Query: 916 TLIVQK---KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
+ +K +E++E+ +IE+ K+ LN + E + + L+++ K E
Sbjct: 276 RQAKELFLLRKTLEEMEL----RIET---QKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+ E + E + HV + E + + K N++L+++ N
Sbjct: 329 D-----HERTRRLAEA-EMHVH--------HLESLLEQKEKENSMLREEMHRRFE-NAPD 373
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV-SKQLLDSKQHNEEL-QILVREQDD 1090
+ + +++ +SK++ L ++EEE+Q + S L +++ EE+ Q+ V
Sbjct: 374 SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKV-Q 1145
+ + K ++ E++ TE + + + +E + SD +++ + Q
Sbjct: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
Query: 1146 EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-----VNQEQINQLK 1200
E + ++ R L+E+ LN + ++ + T E+ HD+ V + ++N L+
Sbjct: 494 TEVDALRLR--LEEKETMLNKKTKQIQDMAEEKGTQAGEI--HDLKDMLDVKERKVNVLQ 549
Query: 1201 SKLEQLNTE---NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT---- 1253
K+E L + + +S++ E S+ + + L ++ LA++E ++
Sbjct: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL-EEALAEKERTIERLKEQR 608
Query: 1254 ---EHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
E E + ++ ++ + L + V +++E + + E +SL + K+ L
Sbjct: 609 DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 668
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK------ 1360
+ L+ + E L+ E + +K L E YK
Sbjct: 669 KTLEIALEQ--KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 726
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQLELKDSEIYQK 1419
Q + +L I +E K R V D KV L H+ +++ + Q
Sbjct: 727 QAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQM 786
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAI-----LRLKMHENA-NHY 1473
E ND + ++ L + + RIE+L + I + L E+A +
Sbjct: 787 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 846
Query: 1474 ETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE-EVAKTNEMQTALE-NQEI 1531
E +E + K+ +EL + S + +AE L + ++ LE QE
Sbjct: 847 EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 906
Query: 1532 EIVTLNDEITNLQNM-VRASSSKIQKHVSFASDTKQGRDEQL-DNTMNKELLDA 1583
+ ++++ N+ + + +S K Q+ V+ K +QL T N+ L A
Sbjct: 907 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMA 960
Score = 50.0 bits (114), Expect = 7e-05
Identities = 96/552 (17%), Positives = 221/552 (40%), Gaps = 31/552 (5%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 442 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 498
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 499 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
Query: 171 TILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA 230
+ D +++++ + +++ TT + ++ + +++E E
Sbjct: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA----EKERTIERLKEQRDRDER 613
Query: 231 EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXX 290
E ++E KD++ ++S L+ EA+ ++ S LA +
Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 673
Query: 291 XXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLA 350
++ ++ E + + + +LE E++ +I+ LE + + + + + ++
Sbjct: 674 ALEQKKEECLK--MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 731
Query: 351 TMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKL 410
+ K V + I+ T+ ++K ++++ + +KK + + +
Sbjct: 732 RLLEILKEVENEKNDKDKKIAELESL-TSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 790
Query: 411 EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+LN + + +KD ++ L +Q+ ++ M T
Sbjct: 791 RRREDNLNDSSQQLQDSLRKKDDRIEEL------EEALRESVQITAEREMVLAQEESART 844
Query: 471 NTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
N E V E+ E++KQEL E + + L E +T L E K++ +V
Sbjct: 845 NAEKQVEELLMAMEKVKQEL--ESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEV 899
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
L++KQ + + S+ D+N ++ L+ ++VA L+ EK L L
Sbjct: 900 -----LEMKQ-EALLAAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 952
Query: 590 SGRM-IESDVYK 600
RM + +D Y+
Sbjct: 953 QNRMKLMADNYE 964
Score = 36.3 bits (80), Expect = 0.91
Identities = 53/262 (20%), Positives = 106/262 (40%), Gaps = 17/262 (6%)
Query: 1355 ENQSYKQMQEQSILNINEENAQ-LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
+ S + E + + EEN Q L + + E ++ L +D
Sbjct: 247 QQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 1414 SEI---YQKTHEYTITLTQRNDEFENVRQQLVEYEKRI---EDLTYEKESELAILRLKMH 1467
I + ++ ++ E R+ L E E + E L +KE E ++LR +MH
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 1468 ---ENA-NHYETMQKESEIE----RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
ENA + +T ++ IE ++ +E + E + + K L+ EE K
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 1520 NEMQTALEN-QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
E+ + + +I + E++ + A +K++ + SD+KQ + ++ K
Sbjct: 426 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 485
Query: 1579 ELLDAVPRAELDLAMYMLHQRD 1600
E A+ + E+D L +++
Sbjct: 486 EQRAAILQTEVDALRLRLEEKE 507
>AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein.
Length = 1003
Score = 91.9 bits (218), Expect = 2e-17
Identities = 134/666 (20%), Positives = 282/666 (42%), Gaps = 54/666 (8%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
KEL L+ + L+ + E T K N +++ + KL +Q L + E+ E
Sbjct: 290 KELFLLRKTLE-EMELRIETQKQTLNARDESIKKLLEMLQSK-----GLSAKATEEDHER 343
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIES--ELSKYKSRICRLEESIAVMEDRRY 793
++ E + ++ K +E + E + E + ++ L+ I + + +
Sbjct: 344 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 403
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S+ER L +Q + + T + +E + ++ V H + ++ ++ +++ E
Sbjct: 404 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 463
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ L + + L SD +QH L E E + QT++ L L+ E
Sbjct: 464 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----E 516
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+T++ +K K+I+D+ E TQ I D K + + E+ + + + IEN
Sbjct: 517 KETMLNKKTKQIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIEN 565
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L + + K + + + V+ Q + + T+ + L L +K+ I L ++ +
Sbjct: 566 LQEQLRDKEKQ-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRD 620
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + +Y+ L K+ ++ ++ LLD K+H L ++D ++K
Sbjct: 621 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 680
Query: 1094 EL-------KETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQ 1145
L KE L E + K + + P MSD +++ + +
Sbjct: 681 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 740
Query: 1146 EEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS-- 1201
+ E ++E + K EL+ ++ Q++ N ++ ++ ++EQ+ + KS
Sbjct: 741 VDRLLEILKEVENEKNDKDKKIAELESLTSR--QVKDQNKKVA--NLKHKEQVEKKKSAQ 796
Query: 1202 KLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQL 1261
LE+ DNL + +L+ S+ D R E+ E ++ + Q A+ + +
Sbjct: 797 MLEEARRREDNLNDSSQQLQDSLRKK-DDRIEELEEALRESV-QITAEREMVLAQEESAR 854
Query: 1262 SAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ E + E+LL +++ QE E+ K +++S Q L +KE HL NL+ + + ++
Sbjct: 855 TNAEKQVEELLMAMEKVKQELESMK----AKLSSTQQSLAEKETHLTNLRAERRKHLEEV 910
Query: 1321 EILRSE 1326
++ E
Sbjct: 911 LEMKQE 916
Score = 77.4 bits (182), Expect = 4e-13
Identities = 122/623 (19%), Positives = 268/623 (43%), Gaps = 62/623 (9%)
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ--KTIDNF--SKVS 551
+ +KD K+ S E + L +EI N + ++KQM+ ++ F +K+
Sbjct: 395 IEMKD--SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIG 452
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL--------VDYDSGRMIESDV---YK 600
+E+ R EL L K+ L + + + H+ +++++V
Sbjct: 453 QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL 512
Query: 601 KMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL----ADISQLQSDQVC 656
++ E E + + K I + +K E+H L+ D E K+ I LQ
Sbjct: 513 RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 572
Query: 657 SEIKSVHLEEQIDALSA--SKKELAL-VIENLKLDKEQLYGTIKD-LENDKEDIMNKLQN 712
E + L+E++ +L A + + AL +E +KE+ +K+ + D+ + ++ N
Sbjct: 573 KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN 632
Query: 713 YIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI--DAKIQERDLYIENIESE 770
Y ++ DL +K+ + + + + ++ +E + G+ D++++ ++ +E + E
Sbjct: 633 YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 692
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
K +S++ + E A +E R + ++ +Q ++ + Y +DE A
Sbjct: 693 CLKMESQLKKAHE--AALE------ARASPEMSDRIQHLEREITRY---KDESSKAQA-- 739
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+ DR++E L E+E+E + KK + E ++L + ++ + ++ + +
Sbjct: 740 -EVDRLLE-ILKEVENEKNDKDKK----IAELESL--TSRQVKDQNKKVANLKHKEQVEK 791
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+S + + R E NL + + Q + +K IE+LE ++ + VL ++
Sbjct: 792 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE 851
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
T E Q++E +E + +E + K L + + +++T T
Sbjct: 852 SAR----TNAEKQVEELLMAMEKVKQELESM-KAKLSSTQQSLAEKETH---LTNLRAER 903
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
L +L+ K E ++A + +A ++ + + S K Q ++ ++ E R+ +Q
Sbjct: 904 RKHLEEVLEMKQEALLAAISE-KDANIALLELSS--SKKKTQ--EEVAALKREKDRLVQQ 958
Query: 1071 LLDSKQHNEELQILVREQDDQIK 1093
L Q+ +L + +DD K
Sbjct: 959 LKQQTQNRMKL-MADNYEDDHFK 980
Score = 71.3 bits (167), Expect = 3e-11
Identities = 112/559 (20%), Positives = 238/559 (42%), Gaps = 51/559 (9%)
Query: 376 RNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
+N ++K S+ +E L T + N+ + + I+ L + L KE + T
Sbjct: 448 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 507
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
K+T++ + + Q E GT +++++ + + ++++N +
Sbjct: 508 DALRLRLEEKETMLNKKTKQIQDMAE-----EKGTQAGEIHDLKDMLDVKERKVN--VLQ 560
Query: 496 VNVKDLIEKLKSAEEQITQLNDEI---DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+++L E+L+ E+Q++ L + + A N + + L + ++TI+ + D
Sbjct: 561 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 620
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR 612
++ EE+ + + + +L+E+ LQ L + ++ + + + ++R
Sbjct: 621 RDER--EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSR 678
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
LK + + QK + ++ +K E A + S ++ I+ HLE +I +
Sbjct: 679 LKTLEIALEQKKEECLKMESQLKKAHE-----AALEARASPEMSDRIQ--HLEREI---T 728
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKI 732
K E + + + ++L +K++EN+K D K I E LT + K +K+
Sbjct: 729 RYKDESS----KAQAEVDRLLEILKEVENEKNDKDKK----IAELESLTSRQVKDQNKKV 780
Query: 733 SELLAKINHEEQSKIQTQFGIDAKIQERDLY--IENIESELSKYKSRICRLEESIAVMED 790
+ L K + + K Q +A+ +E +L + ++ L K RI LEE A+ E
Sbjct: 781 ANL--KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEE--ALRES 836
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ + ER+ L +++ A + Q +EL+ +EK E+E +
Sbjct: 837 VQITAEREM-----VLAQEESARTNAEKQVEELL----------MAMEKVKQELESMKAK 881
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
L Q L E+ +L ++ ++H ++E LA L +L S+ K+
Sbjct: 882 LSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 941
Query: 911 THEHQTLIVQKKKEIEDLE 929
E L +K + ++ L+
Sbjct: 942 QEEVAALKREKDRLVQQLK 960
Score = 69.7 bits (163), Expect = 8e-11
Identities = 160/834 (19%), Positives = 340/834 (40%), Gaps = 81/834 (9%)
Query: 801 QLGSYLQEKQKAYSEYTIQEDEL---VNRLAVLMDHDRVVEKQLLEIEHENKELQKKN-Q 856
QL L+E + ++E +L +N + + E+ L + E + K+ +
Sbjct: 168 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 227
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL-ESNLKRITHEHQ 915
++ EENQ++Q+++ +Q + N+ +S S + + +L E N +R+ EH+
Sbjct: 228 VVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 286
Query: 916 TLIVQK---KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
+ +K +E++E+ +IE+ K+ LN + E + + L+++ K E
Sbjct: 287 RQAKELFLLRKTLEEMEL----RIET---QKQTLNARDESIKKLLEMLQSKGLSAKATEE 339
Query: 973 NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKI 1032
+ E + E + HV + E + + K N++L+++ N
Sbjct: 340 D-----HERTRRLAEA-EMHVH--------HLESLLEQKEKENSMLREEMHRRFE-NAPD 384
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV-SKQLLDSKQHNEEL-QILVREQDD 1090
+ + +++ +SK++ L ++EEE+Q + S L +++ EE+ Q+ V
Sbjct: 385 SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHS 444
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKV-Q 1145
+ + K ++ E++ TE + + + +E + SD +++ + Q
Sbjct: 445 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 504
Query: 1146 EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-----VNQEQINQLK 1200
E + ++ R L+E+ LN + ++ + T E+ HD+ V + ++N L+
Sbjct: 505 TEVDALRLR--LEEKETMLNKKTKQIQDMAEEKGTQAGEI--HDLKDMLDVKERKVNVLQ 560
Query: 1201 SKLEQLNTE---NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT---- 1253
K+E L + + +S++ E S+ + + L ++ LA++E ++
Sbjct: 561 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL-EEALAEKERTIERLKEQR 619
Query: 1254 ---EHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
E E + ++ ++ + L + V +++E + + E +SL + K+ L
Sbjct: 620 DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 679
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK------ 1360
+ L+ + E L+ E + +K L E YK
Sbjct: 680 KTLEIALEQ--KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 737
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR-VNDAEAKVLELTHQLELKDSEIYQK 1419
Q + +L I +E K R V D KV L H+ +++ + Q
Sbjct: 738 QAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQM 797
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAI-----LRLKMHENA-NHY 1473
E ND + ++ L + + RIE+L + I + L E+A +
Sbjct: 798 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 857
Query: 1474 ETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEE-EVAKTNEMQTALE-NQEI 1531
E +E + K+ +EL + S + +AE L + ++ LE QE
Sbjct: 858 EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 917
Query: 1532 EIVTLNDEITNLQNM-VRASSSKIQKHVSFASDTKQGRDEQL-DNTMNKELLDA 1583
+ ++++ N+ + + +S K Q+ V+ K +QL T N+ L A
Sbjct: 918 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMA 971
Score = 50.0 bits (114), Expect = 7e-05
Identities = 96/552 (17%), Positives = 221/552 (40%), Gaps = 31/552 (5%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 453 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 509
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 510 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 568
Query: 171 TILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEA 230
+ D +++++ + +++ TT + ++ + +++E E
Sbjct: 569 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA----EKERTIERLKEQRDRDER 624
Query: 231 EWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXX 290
E ++E KD++ ++S L+ EA+ ++ S LA +
Sbjct: 625 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 684
Query: 291 XXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLA 350
++ ++ E + + + +LE E++ +I+ LE + + + + + ++
Sbjct: 685 ALEQKKEECLK--MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 742
Query: 351 TMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKL 410
+ K V + I+ T+ ++K ++++ + +KK + + +
Sbjct: 743 RLLEILKEVENEKNDKDKKIAELESL-TSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 801
Query: 411 EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+LN + + +KD ++ L +Q+ ++ M T
Sbjct: 802 RRREDNLNDSSQQLQDSLRKKDDRIEEL------EEALRESVQITAEREMVLAQEESART 855
Query: 471 NTE-DVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
N E V E+ E++KQEL E + + L E +T L E K++ +V
Sbjct: 856 NAEKQVEELLMAMEKVKQEL--ESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEV 910
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
L++KQ + + S+ D+N ++ L+ ++VA L+ EK L L
Sbjct: 911 -----LEMKQ-EALLAAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 963
Query: 590 SGRM-IESDVYK 600
RM + +D Y+
Sbjct: 964 QNRMKLMADNYE 975
Score = 36.3 bits (80), Expect = 0.91
Identities = 53/262 (20%), Positives = 106/262 (40%), Gaps = 17/262 (6%)
Query: 1355 ENQSYKQMQEQSILNINEENAQ-LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
+ S + E + + EEN Q L + + E ++ L +D
Sbjct: 258 QQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 317
Query: 1414 SEI---YQKTHEYTITLTQRNDEFENVRQQLVEYEKRI---EDLTYEKESELAILRLKMH 1467
I + ++ ++ E R+ L E E + E L +KE E ++LR +MH
Sbjct: 318 ESIKKLLEMLQSKGLSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSMLREEMH 376
Query: 1468 ---ENA-NHYETMQKESEIE----RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
ENA + +T ++ IE ++ +E + E + + K L+ EE K
Sbjct: 377 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 436
Query: 1520 NEMQTALEN-QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
E+ + + +I + E++ + A +K++ + SD+KQ + ++ K
Sbjct: 437 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 496
Query: 1579 ELLDAVPRAELDLAMYMLHQRD 1600
E A+ + E+D L +++
Sbjct: 497 EQRAAILQTEVDALRLRLEEKE 518
>AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein.
Length = 1642
Score = 91.5 bits (217), Expect = 2e-17
Identities = 175/932 (18%), Positives = 400/932 (42%), Gaps = 85/932 (9%)
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQE 759
E +D L+ E ++E+++ E + E+ E ++Q +A I++
Sbjct: 159 EQGAQDSPTHLEMMESELAGKQHEIEELNRE-LEEMRVTYGTEGLQQLQE---FEAAIKQ 214
Query: 760 RDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ 819
RD I + + L + + + ++ L+ + QL + + +S
Sbjct: 215 RDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA- 273
Query: 820 EDELVNRLAVLMDHDRVVEKQ--LLEIEHENKE--------LQKKNQIL-LEENQNLQIS 868
+L+ ++ H + +E+Q LLE + KE LQ+K ++ +E+++ ++ S
Sbjct: 274 --DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENS 331
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+ Q ++E+ N T + E E K +L+D + ++ E Q IVQK +EI+++
Sbjct: 332 NKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 388
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE-ELNKMNLE 987
++E + + + + + E + Q + ++ + + +L ++ E
Sbjct: 389 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 448
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQVSYMSM-VS 1044
L + + Q+ + Q++ ++ ++ K + E + N +N Q+ M++ ++
Sbjct: 449 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAIN 508
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ KL ++ E ++EE+ + ++ ++ E+L + +QI+ ++T E
Sbjct: 509 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 568
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKL 1164
+ + + ST+E + + L+++ E E + L+ +
Sbjct: 569 KLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKIKLEMLEKEK 619
Query: 1165 NTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN--DNLLSTVA 1218
N L ++ +LE L T+L ++E++++LK LE ++N E DNL
Sbjct: 620 NAVLDRMAESQEAELERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 676
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKYEQL---LDS 1274
+ + + + Q+ E + K +L ++ +L+ +Q S SK E++ ++
Sbjct: 677 QQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 735
Query: 1275 VQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q QEE K ++V LQ K + E+ ++ + + Q+E S ++DE
Sbjct: 736 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 795
Query: 1331 KVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
K +++S + E+ I + EEN LK+
Sbjct: 796 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 855
Query: 1389 XXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
+ AE K E+ +Q EL++ EY L ++D ++ +Q +EY+ ++
Sbjct: 856 EKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNKQELEYKSKL 905
Query: 1449 ----EDLTYEKESELAI-LRLKMHENANHY--ETMQ--KESEIERVKLIEELNVKITESV 1499
E+L ++ + + ++ + + + ET++ + E + +L+E+L V E +
Sbjct: 906 KALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVXEKDTTELMEKLEVTKREKL 965
Query: 1500 SLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
L++++++L++ L+ EEV K + +L +E+EI+ ++ N+ +
Sbjct: 966 ELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRELEIIINHNRAENVXSCD 1025
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
SS + V+ S +G +++ + +E
Sbjct: 1026 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1057
Score = 80.6 bits (190), Expect = 4e-14
Identities = 175/942 (18%), Positives = 390/942 (41%), Gaps = 61/942 (6%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 483 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 541
Query: 207 XXXXXED---TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
E+ +++Q+ + ++ E++ +E + L +E I S E+ K LE
Sbjct: 542 LEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELEL- 599
Query: 264 RFEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIA 319
+ E + + K+ E+ E+ L + + + E+ + K LEI
Sbjct: 600 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 659
Query: 320 NMTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRN 377
+ + K K L H QI E+ K+ TM E + + + IS+ K +
Sbjct: 660 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 719
Query: 378 TASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
+ KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 720 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 779
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 780 EKFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEK 832
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 833 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLE 891
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 892 DSKNKQELEYKS-KLKALNEE---LHLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMG 943
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
+ E +L+++L + +++ E+ +L+D+S+ Q EI L E++ +L K+
Sbjct: 944 EVXEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKPKPGEIS--FLNEEVKSLKPEKE 1000
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
++L L++ + +++ + + + L + +T + + S K+++
Sbjct: 1001 PVSLRCRELEIIIN--HNRAENVXSCDTQVSSLLDGVV----TMTSRGAEGSVSKVNKSF 1054
Query: 737 ---AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+KI E++ + + + ++ L ++++ S + R + E+ + ++
Sbjct: 1055 GEESKIMVEDKVSFE-NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 1113
Query: 794 SLERKADQLGSYLQEKQKAYS-EYTIQEDELVNRLAVLMDHD--RVVEKQLLEIEHENKE 850
L+ + + L ++ ++ S Y+ D++ + D + E+ + E + KE
Sbjct: 1114 -LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1172
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE---------SESTKYQTQLR 901
LQK +Q+ L+ + + D + + L+ K + E S +Y T
Sbjct: 1173 LQKIHQLELQTMKTQE--TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1230
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
E N + + + + E++D E E+ + E+Y K + T+L
Sbjct: 1231 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL- 1289
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+++ + + L E L K E + H Q T D + ++++ L L K K
Sbjct: 1290 SKIWGQQTDGMKLEFGEENLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSLQDLEKTK 1347
Query: 1022 -DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
+E++ L I++ +YE+++ +L+ + E
Sbjct: 1348 LEEQVQELESLISSLXQQLKETEQNYEAEIHCLQKRLQAVSE 1389
Score = 65.7 bits (153), Expect = 1e-09
Identities = 130/687 (18%), Positives = 274/687 (39%), Gaps = 61/687 (8%)
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + +E I +T I + ++ + + ++E +++ + + + +
Sbjct: 77 MYINSSQRVESTVIPEST-IMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 135
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+ NL L ++ + S + + + + L K EI LN+++ +
Sbjct: 136 VMRTGKPTNL-LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR 194
Query: 1037 VSY----MSMVSDYESKL-------AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
V+Y + + ++E+ + Q T L+ E ++ L+ + +++LQI
Sbjct: 195 VTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 254
Query: 1086 RE--QDDQIKELKETKLTFEMNIPKTEGMIISSTIEP----MSDDANNVDXXXXXXXXXX 1139
++ + ++ + ++ K + + +E + D +
Sbjct: 255 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 314
Query: 1140 XXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
+KV E E+ + + +E+ + T ++E TKII+ E EL + + +L
Sbjct: 315 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 374
Query: 1200 KSKLEQLNTENDNL---LSTVAELRSSISSAVDQRGFEIAELWKQHL--AQREADF-QKT 1253
+ ++ Q N E N+ L+ + S + Q + EL K++ +Q E D Q+
Sbjct: 375 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 434
Query: 1254 EHELRVQLSAFESKYEQLLDS--VQSSTQEETNKIVTMEQV-TSLQNKLQDKEEHLRNL- 1309
E E + +L ++ +++ VQ + + ME++ T + ++++ N+
Sbjct: 435 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 494
Query: 1310 ----QEKYADV-INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR--TENQSYKQM 1362
Q K +V IN++ I + +K L E S+ +
Sbjct: 495 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 554
Query: 1363 Q-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA-KVLELTHQLELKDSEI---- 1416
Q +++ I E+ ++L ++ V+ +E+ K LEL H+ E+ + +I
Sbjct: 555 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 614
Query: 1417 --YQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIEDLTYEKESELAILRLKMHENAN-H 1472
+K + E E +R QL+ +E+ + L + E E I K+ +N H
Sbjct: 615 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 674
Query: 1473 Y---------ETMQK--ESEIERVKLIEELNVKITESVSL-NKQVAELNKALEEEVAKTN 1520
Y E QK + E+ LI + N I E L + Q + +N EE + N
Sbjct: 675 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQIN 734
Query: 1521 EMQTALE---NQEIEIVTLNDEITNLQ 1544
E+Q +E +E E TL E+ LQ
Sbjct: 735 ELQKEIEILRQEEKEKGTLEQEVQELQ 761
Score = 46.0 bits (104), Expect = 0.001
Identities = 155/800 (19%), Positives = 325/800 (40%), Gaps = 81/800 (10%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-LLEAARFEISLEHSK 273
KQQ+ +Q + EK L+ + IS L++ + L+ + E++L+ ++
Sbjct: 676 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 735
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
L +E+E +Q ++ + KTE+ EK E N +L +K LE
Sbjct: 736 LQKEIE-----ILRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKEN--DLQEKFAQLEA 787
Query: 334 LNCQIRQTNKELENKL---ATMGTESKAV--SSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
N ++ K LE+ L + E + + S K + K + + Q
Sbjct: 788 ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 847
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY--VISEKDTXXXXXXXXXXGKD 446
LN++ +K+ N A+ + N + +EY ++ KD
Sbjct: 848 CIQ--LNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDLEDSKNKQELEYK 902
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVN--------EIAKVQEQLKQELNDEIKDVNV 498
+ + L E P+ + + ++ D + E+ +V E+ EL ++++
Sbjct: 903 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVXEKDTTELMEKLEVTKR 962
Query: 499 K--DLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK---LKLKQMQKTIDN--FSKVS 551
+ +L ++L EQ+ EI N+ + +K + L+ ++++ I++ V
Sbjct: 963 EKLELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRELEIIINHNRAENVX 1022
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMI-----EM 605
+ ++ L + + ++ + AE K N +S M+E V ++ M +
Sbjct: 1023 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF---GEESKIMVEDKVSFENMTVGEESKQ 1079
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVC-SEIKSVH 663
E L L +++ S + E LQ++ + ++ + D+ Q+++ ++C S + S H
Sbjct: 1080 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1139
Query: 664 LEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL-- 720
+++ + + K K L + E L +E+ ++ + + M K Q E L
Sbjct: 1140 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHL 1198
Query: 721 -TDKLEKMSAEKISELL----AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
KL+K +E+ S L + + ++ + + K D EN + EL Y+
Sbjct: 1199 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1258
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMD 832
+ +E++ + ++ K L + L + +Q + E+ L +
Sbjct: 1259 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1318
Query: 833 -HDRVVEKQLLEIEHENK--ELQKKNQILLEEN--------QNLQISLSDMQQHYNALVE 881
H ++ + +++ H++K LQ + LEE +L L + +Q+Y A +
Sbjct: 1319 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLXQQLKETEQNYEAEIH 1378
Query: 882 KANRTDLAESESTKYQTQLRD----LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-- 935
+ A SEST + D ES+ +R + + KK I D IEF+ +
Sbjct: 1379 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCV----KKNI-DGTIEFSGEFG 1433
Query: 936 IESAIRDKKVLNEKYEKNIE 955
++ K+L ++Y++ +E
Sbjct: 1434 VKEETNIVKLLEKQYQEQLE 1453
>BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 14
protein.
Length = 980
Score = 90.6 bits (215), Expect = 4e-17
Identities = 100/500 (20%), Positives = 227/500 (45%), Gaps = 28/500 (5%)
Query: 482 QEQLKQELND---EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
++QL+ EL E+ +N ++ E +++ + + + A K ++ V+ KL L
Sbjct: 452 RKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLV 511
Query: 539 QMQKTIDNFSKVSD---SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+ ++DN+S + + +EI L ++L + ++ +E+ L+ LV+ + G +I+
Sbjct: 512 SPE-SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 570
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL-ADISQLQSDQ 654
V E E + + I + +K L ++ Q++ +++D L + ++Q SD+
Sbjct: 571 PPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDE 626
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
++K + ID L+ EL+ + + + + E Y K LE+ + ++K ++
Sbjct: 627 A-EDMKEA-MNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLEDVTAEYIHKAEH-- 681
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK------IQERDLYIENIE 768
++ M LT+ + + +SE+ ++ + Q + +DA+ I E I +
Sbjct: 682 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLR 741
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ + + +I L+E +A E LE++ + + + + S Y + L + ++
Sbjct: 742 TAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVS 801
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
VL + K+ ++ E +++ + + E +N+Q L +Q N L++K +
Sbjct: 802 VLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQE 861
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
+E +Y LE + + +E + + K+ + L +Q+ + K ++
Sbjct: 862 ELAEMKRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSL-----SQLSYSTSSSKRQSQ 916
Query: 949 KYEKNIEYVTQLEAQLQEYK 968
+ E + V QL+ QL E K
Sbjct: 917 QLEALQQQVKQLQNQLAECK 936
Score = 69.7 bits (163), Expect = 8e-11
Identities = 114/550 (20%), Positives = 248/550 (45%), Gaps = 51/550 (9%)
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL----L 619
+H L + + + LQ L D R+ S+ +K +++E L R + + L +
Sbjct: 417 IHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVE-LQSRRAELVCLNNTEI 474
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-----LQSDQVCSEIKSVH-LEEQIDALSA 673
DL Q+L Q KY+E ++ + + L S + H L + ++
Sbjct: 475 SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV 534
Query: 674 SKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNK-LQNYIQENMDLTDKLEKMSAEK 731
K++L +E + +KE++ + L E +K ++ ++ Y + +E M+ EK
Sbjct: 535 LKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEK 594
Query: 732 ISELLAKINHEEQS------KIQTQFGIDAKIQERDLY--IENIESELSKYKSRICRL-E 782
+ L K ++ +++Q +A + D+ + + EL+K S + +L +
Sbjct: 595 -AFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYK 653
Query: 783 ESIAVMED--RRYSLERKADQLGSYLQ--EKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E+ A +ED +R SLE D Y+ E +K + + + L+ + V
Sbjct: 654 EAQAELEDYRKRKSLE---DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 710
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+L +++ + + QK+N + + E+ LQ+ ++ ++ + EK + +L E ++K +
Sbjct: 711 NELTQLK-QLVDAQKENSVSITEH--LQV-ITTLRTAAKEMEEKIS--NLKEHLASK-EV 763
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES-AIRDKKVLNEKYEKNIEYV 957
++ LE L T + + E L+ +++ A + K+ + EK EK V
Sbjct: 764 EVAKLEKQLLE-EKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK-EKVHSEV 821
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ--TQSPDYTEQYINEINKLN 1015
Q+ +++ + K EN+ ++ + EL+ K Q Q+ + Y+E +
Sbjct: 822 VQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKD 881
Query: 1016 ALLKQKDEEIIALNQKINN-AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD- 1073
+ + +E+ L + +N+ +Q+SY + S +S+ +LE ++++++++ QL +
Sbjct: 882 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQ------QLEALQQQVKQLQNQLAEC 935
Query: 1074 SKQHNEELQI 1083
KQH E + +
Sbjct: 936 KKQHQEVISV 945
Score = 56.4 bits (130), Expect = 8e-07
Identities = 104/527 (19%), Positives = 215/527 (40%), Gaps = 52/527 (9%)
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E +L L+ + E++ LN N ++S S SD KL + +K E +E+ V K
Sbjct: 451 ERKQLQVELQSRRAELVCLN----NTEISENS--SDLSQKLKETQSKYEEAMKEVLSVQK 504
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNV 1128
Q+ +L ++ E D E ++T E +N+ K + E + +
Sbjct: 505 QM--------KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVREL 556
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQER--SVLQ---EQSAKLNTELQECYTKIIQL-ETLN 1182
+ EE E ++ SV++ ++ A L + QE +I++L +TL
Sbjct: 557 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 1183 TELTGHDVVNQEQINQLKSKL-EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+++T E + + +++ ++LN + L E ++ + ++ E
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 1242 HLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQS-----STQEETNKIVT--MEQ 1291
H A+ E Q T + LS +S+Y ++L+ + Q+E + +T ++
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 736
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+T+L+ ++ EE + NL+E A ++ L ++ +EK A D
Sbjct: 737 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM---------------TD 781
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKS-SXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
SY+++Q ++ ++LK+S R ++ K + Q
Sbjct: 782 AMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 841
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
LK E Q+ +E Q +E ++ + E ++E+ +K +E++ K+ E
Sbjct: 842 LKSKE--QEVNELLQKFQQAQEELAEMK-RYSESSSKLEEDKDKKINEMSKEVTKLKEAL 898
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
N + + + + ++L + L Q+AE K +E ++
Sbjct: 899 NSLSQLSYSTSSSK-RQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Score = 52.0 bits (119), Expect = 2e-05
Identities = 111/616 (18%), Positives = 253/616 (41%), Gaps = 57/616 (9%)
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI-KDLENDKED 705
+S LQ+ + + L++++ A S + E L ++ + L ++ K E D
Sbjct: 349 LSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPD 408
Query: 706 IMNKLQNYIQE-NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
+ I TD + +++ E+L + +S + + ++Q R +
Sbjct: 409 SKSSPSVLIHSLGKSTTDN--DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL 466
Query: 765 ENIES-ELSKYKSRIC-RLEESIAVMEDRRYSL--ERKADQLGSYLQEKQKAYSEYTIQE 820
+ + E+S+ S + +L+E+ + E+ + +K +LG E YS + E
Sbjct: 467 VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHF--HE 524
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS-----LSDMQQH 875
+ ++ D ++ L E E +++++ + L+E + I +M+
Sbjct: 525 LRVTEEEINVLKQD--LQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSS 582
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
Y +++E N+ E KYQ ++ LK T + E ED++ N
Sbjct: 583 YCSVIENMNKEKAFLFE--KYQEAQEEI-MKLKDTLKSQMTQ--EASDEAEDMKEAMNRM 637
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN----LELIDK 991
I+ + L++ Y+ + +A+L++Y+ ++ E ++K ++L +
Sbjct: 638 IDELNKQVSELSQLYK-------EAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNV 690
Query: 992 HVQKQQTQSPDYTEQY---INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
K + + QY +NE+ +L L+ + E +++ + + + + + E
Sbjct: 691 SRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQ-VITTLRTAAKEMEE 749
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF------ 1102
K++ L + E E+ ++ KQLL+ K + + R ++++ E++++
Sbjct: 750 KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV-PRSSYEKLQSSLESEVSVLASKLK 808
Query: 1103 ----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQERSV 1156
E +E + I S + + + N+ L K Q+ +E + E
Sbjct: 809 ESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR 868
Query: 1157 LQEQSAKLNTE----LQECYTKIIQL-ETLNT--ELTGHDVVNQEQINQLKSKLEQLNTE 1209
E S+KL + + E ++ +L E LN+ +L+ ++ Q QL++ +Q+
Sbjct: 869 YSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQL 928
Query: 1210 NDNLLSTVAELRSSIS 1225
+ L + + IS
Sbjct: 929 QNQLAECKKQHQEVIS 944
Score = 42.7 bits (96), Expect = 0.011
Identities = 80/449 (17%), Positives = 172/449 (38%), Gaps = 35/449 (7%)
Query: 1175 IIQLETLNTELTGHDV-VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSI----SSAVD 1229
++ E+++ H++ V +E+IN LK L+ E++ V EL + V
Sbjct: 510 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI 569
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS-TQEETNKIVT 1288
+ E E K + K + L + + + +L D+++S TQE +++
Sbjct: 570 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 629
Query: 1289 MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXXXX 1346
M++ ++ + + + + L + Y + ++E R +ED +
Sbjct: 630 MKE--AMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQL 687
Query: 1347 XXXXDLRTENQ-SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+ E+ S + Q +LN + QL + + E+
Sbjct: 688 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEM 747
Query: 1406 THQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
++ + K E Q +E + +V E L ESE+++L K
Sbjct: 748 EEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP-RSSYEKLQSSLESEVSVLASK 806
Query: 1466 MHENAN-----HYETMQKESEIERVK--------LI----EELNVKITESVSLNKQVAEL 1508
+ E+ H E +Q SE+ +VK L+ +E+N + + +++AE+
Sbjct: 807 LKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEM 866
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+ E + + E+ L + + +L + ++SS K S + Q +
Sbjct: 867 KRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS--SKRQSQQLEALQQQ 924
Query: 1569 DEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+QL N +L + + + +++Y +H
Sbjct: 925 VKQLQN----QLAECKKQHQEVISVYRMH 949
Score = 34.3 bits (75), Expect = 3.7
Identities = 67/333 (20%), Positives = 134/333 (40%), Gaps = 23/333 (6%)
Query: 94 LANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT-IK 152
+ N K+K L EK ++ +E I++ + D+ N I
Sbjct: 587 IENMNKEKAFLFEKYQEAQE-------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 639
Query: 153 EKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKAT-TXXXXXXXXXXXXXXXXX 211
E + +S L K + + D +++ + +D E +KA
Sbjct: 640 ELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL 699
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ K Q +K+ ++ +K+ + E V I++L A K +E +IS
Sbjct: 700 SEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV-ITTLRTAAKEMEE---KISNLK 755
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTE--IEEKGSLEIANMTELTKKIE 329
LA + + + + S EK + +E + S+ + + E K+ E
Sbjct: 756 EHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKE 815
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRNTASKMKSPWSQ 388
+ QIR +++ + + T K S ++ + L+ + + + ++MK +S+
Sbjct: 816 KVHSEVVQIRSEVSQVKREKENIQTLLK---SKEQEVNELLQKFQQAQEELAEMKR-YSE 871
Query: 389 LSSETLNQDTDKKINK--NEIAKLEMVIQSLNK 419
SS+ L +D DKKIN+ E+ KL+ + SL++
Sbjct: 872 SSSK-LEEDKDKKINEMSKEVTKLKEALNSLSQ 903
>AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 14
isoform protein.
Length = 972
Score = 90.6 bits (215), Expect = 4e-17
Identities = 101/500 (20%), Positives = 226/500 (45%), Gaps = 28/500 (5%)
Query: 482 QEQLKQELND---EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
++QL+ EL E+ +N ++ E +++ + + + A K ++ V+ KL L
Sbjct: 444 RKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSQYEEAMKEVLSVQKQMKLGLV 503
Query: 539 QMQKTIDNFSKVSD---SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+ ++DN+S + + +EI L ++L + ++ +E+ L+ LV+ + G +I+
Sbjct: 504 SPE-SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 562
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL-ADISQLQSDQ 654
V E E + + I + +K L ++ Q+ E++D L + ++Q SD+
Sbjct: 563 PPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYPEAQEGIMELKDTLKSQMTQEASDE 618
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
++K + ID L+ EL+ + + + + E Y K LE+ + ++K ++
Sbjct: 619 A-EDMKEA-MNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLEDVTAEYIHKAEH-- 673
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK------IQERDLYIENIE 768
++ M LT+ + + +SE+ ++ + Q + +DA+ I E I +
Sbjct: 674 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLR 733
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ + + +I L+E +A E LE++ + + + + S Y + L + ++
Sbjct: 734 TAAKEMEEKISNLKEHLASKEVEVLKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVS 793
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
VL + K+ ++ E +++ + + E +N+Q L +Q N L++K +
Sbjct: 794 VLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQE 853
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
+E +Y LE + + +E + + K+ + L +Q+ + K ++
Sbjct: 854 ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSL-----SQLSYSTSSSKRQSQ 908
Query: 949 KYEKNIEYVTQLEAQLQEYK 968
+ E + V QL+ QL E K
Sbjct: 909 QLEALQQQVKQLQNQLAECK 928
Score = 64.5 bits (150), Expect = 3e-09
Identities = 106/520 (20%), Positives = 241/520 (46%), Gaps = 46/520 (8%)
Query: 592 RMIESDVYKKMIEMENLAETRLKAISL----LESQKFDLVQELHILQQKYDEVEDKLADI 647
R+ S+ +K +++E L R + + L + DL Q+L Q +Y+E ++ +
Sbjct: 436 RLESSEAERKQLQVE-LQSRRAELVCLNNTEISENSSDLSQKLKETQSQYEEAMKEVLSV 494
Query: 648 SQ-----LQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL-E 700
+ L S + H L + ++ K++L +E + +KE++ + L E
Sbjct: 495 QKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE 554
Query: 701 NDKEDIMNK-LQNYIQENMDLTDKLEKMSAEK--ISELLAKINH---EEQSKIQTQFGID 754
+K ++ ++ Y + +E M+ EK + E + E + +++Q +
Sbjct: 555 REKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYPEAQEGIMELKDTLKSQMTQE 614
Query: 755 AKIQERDLY--IENIESELSKYKSRICRL-EESIAVMED--RRYSLERKADQLGSYLQ-- 807
A + D+ + + EL+K S + +L +E+ A +ED +R SLE D Y+
Sbjct: 615 ASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE---DVTAEYIHKA 671
Query: 808 EKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
E +K + + + L+ + V +L +++ + + QK+N + + E+ LQ+
Sbjct: 672 EHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLK-QLVDAQKENSVSITEH--LQV 728
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
++ ++ + EK + +L E ++K + ++ LE L T + + E
Sbjct: 729 -ITTLRTAAKEMEEKIS--NLKEHLASK-EVEVLKLEKQLLE-EKAAMTDAMVPRSSYEK 783
Query: 928 LEIEFNTQIES-AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
L+ +++ A + K+ + EK EK V Q+ +++ + K EN+ ++ +
Sbjct: 784 LQSSLESEVSVLASKLKESVKEK-EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVN 842
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ--VSYMSMVS 1044
EL+ K Q Q+ + ++Y +KL + KD++I +++++ + ++ +S +S
Sbjct: 843 ELLQKFQQAQEELAE--MKRYAESSSKLE---EDKDKKINEMSKEVTKLKEALNSLSQLS 897
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLD-SKQHNEELQI 1083
S + + +LE ++++++++ QL + KQH E + +
Sbjct: 898 YSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISV 937
Score = 51.6 bits (118), Expect = 2e-05
Identities = 102/527 (19%), Positives = 213/527 (40%), Gaps = 52/527 (9%)
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E +L L+ + E++ LN N ++S S SD KL + ++ E +E+ V K
Sbjct: 443 ERKQLQVELQSRRAELVCLN----NTEISENS--SDLSQKLKETQSQYEEAMKEVLSVQK 496
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNV 1128
Q+ +L ++ E D E ++T E +N+ K + E + +
Sbjct: 497 QM--------KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVREL 548
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQER--SVLQ---EQSAKLNTELQECYTKIIQL-ETLN 1182
+ EE E ++ SV++ ++ A L + E I++L +TL
Sbjct: 549 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYPEAQEGIMELKDTLK 608
Query: 1183 TELTGHDVVNQEQINQLKSKL-EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+++T E + + +++ ++LN + L E ++ + ++ E
Sbjct: 609 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 668
Query: 1242 HLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQS-----STQEETNKIVT--MEQ 1291
H A+ E Q T + LS +S+Y ++L+ + Q+E + +T ++
Sbjct: 669 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 728
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+T+L+ ++ EE + NL+E A ++ L ++ +EK A D
Sbjct: 729 ITTLRTAAKEMEEKISNLKEHLASKEVEVLKLEKQLLEEKAAM---------------TD 773
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKS-SXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
SY+++Q ++ ++LK+S R ++ K + Q
Sbjct: 774 AMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 833
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
LK E Q+ +E Q +E ++ + E ++E+ +K +E++ K+ E
Sbjct: 834 LKSKE--QEVNELLQKFQQAQEELAEMK-RYAESSSKLEEDKDKKINEMSKEVTKLKEAL 890
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
N + + + + ++L + L Q+AE K +E ++
Sbjct: 891 NSLSQLSYSTSSSK-RQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 936
Score = 50.8 bits (116), Expect = 4e-05
Identities = 106/565 (18%), Positives = 237/565 (41%), Gaps = 64/565 (11%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIMNKLQNYIQENMDLTD 722
L++++++ A +K+L + +++ + + L T I + +D + + Q+ +E M
Sbjct: 433 LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSQYEEAMKEVL 492
Query: 723 KLEK-MSAEKIS-ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
++K M +S E + +H + ++ + + + ++DL +N E + K ++
Sbjct: 493 SVQKQMKLGLVSPESMDNYSHFHELRVTEE---EINVLKQDL--QNALEESERNKEKVRE 547
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
LEE + E K + ++E ++ S Y + + A L + ++
Sbjct: 548 LEEKLVERE--------KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYPEAQEG 599
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
++E++ K+Q+ E + + DM++ N ++++ N+ S Y+
Sbjct: 600 IMELKDT-----LKSQMTQEASDEAE----DMKEAMNRMIDELNKQ--VSELSQLYKEAQ 648
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+LE KR + E T K E E L N A + +Y K + +TQL
Sbjct: 649 AELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL 708
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
+ + K N ++ +++ + L K ++++ + ++ E+ KL KQ
Sbjct: 709 KQLVDAQKENSVSITEHLQVIT--TLRTAAKEMEEKISNLKEHLASKEVEVLKLE---KQ 763
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
EE A+ + + SY + S ES+++ +KL+ +E ++V H+E
Sbjct: 764 LLEEKAAMTDAMV-PRSSYEKLQSSLESEVSVLASKLKESVKEKEKV---------HSEV 813
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+QI R + Q+K KE T + K++ ++ ++
Sbjct: 814 VQI--RSEVSQVKREKENIQT----LLKSKEQEVNELLQKFQQAQE-------------- 853
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
++ E + + + S L+E K E+ + TK+ + ++L+ ++ Q QL+
Sbjct: 854 --ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 911
Query: 1201 SKLEQLNTENDNLLSTVAELRSSIS 1225
+ +Q+ + L + + IS
Sbjct: 912 ALQQQVKQLQNQLAECKKQHQEVIS 936
Score = 41.5 bits (93), Expect = 0.024
Identities = 80/451 (17%), Positives = 176/451 (39%), Gaps = 39/451 (8%)
Query: 1175 IIQLETLNTELTGHDV-VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
++ E+++ H++ V +E+IN LK L+ E++ V EL + ++G
Sbjct: 502 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVER--EKGT 559
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE------QLLDSVQSS-TQEETNKI 1286
I +++ + + E+ + + FE E +L D+++S TQE +++
Sbjct: 560 VIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYPEAQEGIMELKDTLKSQMTQEASDEA 619
Query: 1287 VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXX 1344
M++ ++ + + + + L + Y + ++E R +ED +
Sbjct: 620 EDMKE--AMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLM 677
Query: 1345 XXXXXXDLRTENQ-SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVL 1403
+ E+ S + Q +LN + QL + +
Sbjct: 678 QLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAK 737
Query: 1404 ELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILR 1463
E+ ++ + K E Q +E + +V E L ESE+++L
Sbjct: 738 EMEEKISNLKEHLASKEVEVLKLEKQLLEEKAAMTDAMVP-RSSYEKLQSSLESEVSVLA 796
Query: 1464 LKMHENAN-----HYETMQKESEIERVK--------LI----EELNVKITESVSLNKQVA 1506
K+ E+ H E +Q SE+ +VK L+ +E+N + + +++A
Sbjct: 797 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 856
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ 1566
E+ + E + + E+ L + + +L + ++SS K S + Q
Sbjct: 857 EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS--SKRQSQQLEALQ 914
Query: 1567 GRDEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+ +QL N +L + + + +++Y +H
Sbjct: 915 QQVKQLQN----QLAECKKQHQEVISVYRMH 941
>AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein.
Length = 989
Score = 90.6 bits (215), Expect = 4e-17
Identities = 100/500 (20%), Positives = 227/500 (45%), Gaps = 28/500 (5%)
Query: 482 QEQLKQELND---EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
++QL+ EL E+ +N ++ E +++ + + + A K ++ V+ KL L
Sbjct: 461 RKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLV 520
Query: 539 QMQKTIDNFSKVSD---SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+ ++DN+S + + +EI L ++L + ++ +E+ L+ LV+ + G +I+
Sbjct: 521 SPE-SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 579
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL-ADISQLQSDQ 654
V E E + + I + +K L ++ Q++ +++D L + ++Q SD+
Sbjct: 580 PPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDE 635
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
++K + ID L+ EL+ + + + + E Y K LE+ + ++K ++
Sbjct: 636 A-EDMKEA-MNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLEDVTAEYIHKAEH-- 690
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK------IQERDLYIENIE 768
++ M LT+ + + +SE+ ++ + Q + +DA+ I E I +
Sbjct: 691 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLR 750
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ + + +I L+E +A E LE++ + + + + S Y + L + ++
Sbjct: 751 TAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVS 810
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
VL + K+ ++ E +++ + + E +N+Q L +Q N L++K +
Sbjct: 811 VLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQE 870
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
+E +Y LE + + +E + + K+ + L +Q+ + K ++
Sbjct: 871 ELAEMKRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSL-----SQLSYSTSSSKRQSQ 925
Query: 949 KYEKNIEYVTQLEAQLQEYK 968
+ E + V QL+ QL E K
Sbjct: 926 QLEALQQQVKQLQNQLAECK 945
Score = 69.7 bits (163), Expect = 8e-11
Identities = 114/550 (20%), Positives = 248/550 (45%), Gaps = 51/550 (9%)
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL----L 619
+H L + + + LQ L D R+ S+ +K +++E L R + + L +
Sbjct: 426 IHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVE-LQSRRAELVCLNNTEI 483
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-----LQSDQVCSEIKSVH-LEEQIDALSA 673
DL Q+L Q KY+E ++ + + L S + H L + ++
Sbjct: 484 SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV 543
Query: 674 SKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNK-LQNYIQENMDLTDKLEKMSAEK 731
K++L +E + +KE++ + L E +K ++ ++ Y + +E M+ EK
Sbjct: 544 LKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEK 603
Query: 732 ISELLAKINHEEQS------KIQTQFGIDAKIQERDLY--IENIESELSKYKSRICRL-E 782
+ L K ++ +++Q +A + D+ + + EL+K S + +L +
Sbjct: 604 -AFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYK 662
Query: 783 ESIAVMED--RRYSLERKADQLGSYLQ--EKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E+ A +ED +R SLE D Y+ E +K + + + L+ + V
Sbjct: 663 EAQAELEDYRKRKSLE---DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 719
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+L +++ + + QK+N + + E+ LQ+ ++ ++ + EK + +L E ++K +
Sbjct: 720 NELTQLK-QLVDAQKENSVSITEH--LQV-ITTLRTAAKEMEEKIS--NLKEHLASK-EV 772
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES-AIRDKKVLNEKYEKNIEYV 957
++ LE L T + + E L+ +++ A + K+ + EK EK V
Sbjct: 773 EVAKLEKQLLE-EKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK-EKVHSEV 830
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ--TQSPDYTEQYINEINKLN 1015
Q+ +++ + K EN+ ++ + EL+ K Q Q+ + Y+E +
Sbjct: 831 VQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKD 890
Query: 1016 ALLKQKDEEIIALNQKINN-AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD- 1073
+ + +E+ L + +N+ +Q+SY + S +S+ +LE ++++++++ QL +
Sbjct: 891 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQ------QLEALQQQVKQLQNQLAEC 944
Query: 1074 SKQHNEELQI 1083
KQH E + +
Sbjct: 945 KKQHQEVISV 954
Score = 56.4 bits (130), Expect = 8e-07
Identities = 104/527 (19%), Positives = 215/527 (40%), Gaps = 52/527 (9%)
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E +L L+ + E++ LN N ++S S SD KL + +K E +E+ V K
Sbjct: 460 ERKQLQVELQSRRAELVCLN----NTEISENS--SDLSQKLKETQSKYEEAMKEVLSVQK 513
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNV 1128
Q+ +L ++ E D E ++T E +N+ K + E + +
Sbjct: 514 QM--------KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVREL 565
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQER--SVLQ---EQSAKLNTELQECYTKIIQL-ETLN 1182
+ EE E ++ SV++ ++ A L + QE +I++L +TL
Sbjct: 566 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 625
Query: 1183 TELTGHDVVNQEQINQLKSKL-EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+++T E + + +++ ++LN + L E ++ + ++ E
Sbjct: 626 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 685
Query: 1242 HLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQS-----STQEETNKIVT--MEQ 1291
H A+ E Q T + LS +S+Y ++L+ + Q+E + +T ++
Sbjct: 686 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 745
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+T+L+ ++ EE + NL+E A ++ L ++ +EK A D
Sbjct: 746 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM---------------TD 790
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKS-SXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
SY+++Q ++ ++LK+S R ++ K + Q
Sbjct: 791 AMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 850
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
LK E Q+ +E Q +E ++ + E ++E+ +K +E++ K+ E
Sbjct: 851 LKSKE--QEVNELLQKFQQAQEELAEMK-RYSESSSKLEEDKDKKINEMSKEVTKLKEAL 907
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
N + + + + ++L + L Q+AE K +E ++
Sbjct: 908 NSLSQLSYSTSSSK-RQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 953
Score = 52.0 bits (119), Expect = 2e-05
Identities = 111/616 (18%), Positives = 253/616 (41%), Gaps = 57/616 (9%)
Query: 647 ISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI-KDLENDKED 705
+S LQ+ + + L++++ A S + E L ++ + L ++ K E D
Sbjct: 358 LSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPD 417
Query: 706 IMNKLQNYIQE-NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
+ I TD + +++ E+L + +S + + ++Q R +
Sbjct: 418 SKSSPSVLIHSLGKSTTDN--DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL 475
Query: 765 ENIES-ELSKYKSRIC-RLEESIAVMEDRRYSL--ERKADQLGSYLQEKQKAYSEYTIQE 820
+ + E+S+ S + +L+E+ + E+ + +K +LG E YS + E
Sbjct: 476 VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHF--HE 533
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS-----LSDMQQH 875
+ ++ D ++ L E E +++++ + L+E + I +M+
Sbjct: 534 LRVTEEEINVLKQD--LQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSS 591
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
Y +++E N+ E KYQ ++ LK T + E ED++ N
Sbjct: 592 YCSVIENMNKEKAFLFE--KYQEAQEEI-MKLKDTLKSQMTQ--EASDEAEDMKEAMNRM 646
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN----LELIDK 991
I+ + L++ Y+ + +A+L++Y+ ++ E ++K ++L +
Sbjct: 647 IDELNKQVSELSQLYK-------EAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNV 699
Query: 992 HVQKQQTQSPDYTEQY---INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
K + + QY +NE+ +L L+ + E +++ + + + + + E
Sbjct: 700 SRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQ-VITTLRTAAKEMEE 758
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF------ 1102
K++ L + E E+ ++ KQLL+ K + + R ++++ E++++
Sbjct: 759 KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV-PRSSYEKLQSSLESEVSVLASKLK 817
Query: 1103 ----EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL--KVQEEEEFIQERSV 1156
E +E + I S + + + N+ L K Q+ +E + E
Sbjct: 818 ESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR 877
Query: 1157 LQEQSAKLNTE----LQECYTKIIQL-ETLNT--ELTGHDVVNQEQINQLKSKLEQLNTE 1209
E S+KL + + E ++ +L E LN+ +L+ ++ Q QL++ +Q+
Sbjct: 878 YSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQL 937
Query: 1210 NDNLLSTVAELRSSIS 1225
+ L + + IS
Sbjct: 938 QNQLAECKKQHQEVIS 953
Score = 42.7 bits (96), Expect = 0.011
Identities = 80/449 (17%), Positives = 172/449 (38%), Gaps = 35/449 (7%)
Query: 1175 IIQLETLNTELTGHDV-VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSI----SSAVD 1229
++ E+++ H++ V +E+IN LK L+ E++ V EL + V
Sbjct: 519 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI 578
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS-TQEETNKIVT 1288
+ E E K + K + L + + + +L D+++S TQE +++
Sbjct: 579 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 638
Query: 1289 MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXXXX 1346
M++ ++ + + + + L + Y + ++E R +ED +
Sbjct: 639 MKE--AMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQL 696
Query: 1347 XXXXDLRTENQ-SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+ E+ S + Q +LN + QL + + E+
Sbjct: 697 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEM 756
Query: 1406 THQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
++ + K E Q +E + +V E L ESE+++L K
Sbjct: 757 EEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP-RSSYEKLQSSLESEVSVLASK 815
Query: 1466 MHENAN-----HYETMQKESEIERVK--------LI----EELNVKITESVSLNKQVAEL 1508
+ E+ H E +Q SE+ +VK L+ +E+N + + +++AE+
Sbjct: 816 LKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEM 875
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+ E + + E+ L + + +L + ++SS K S + Q +
Sbjct: 876 KRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS--SKRQSQQLEALQQQ 933
Query: 1569 DEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+QL N +L + + + +++Y +H
Sbjct: 934 VKQLQN----QLAECKKQHQEVISVYRMH 958
Score = 34.3 bits (75), Expect = 3.7
Identities = 67/333 (20%), Positives = 134/333 (40%), Gaps = 23/333 (6%)
Query: 94 LANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT-IK 152
+ N K+K L EK ++ +E I++ + D+ N I
Sbjct: 596 IENMNKEKAFLFEKYQEAQE-------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 648
Query: 153 EKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKAT-TXXXXXXXXXXXXXXXXX 211
E + +S L K + + D +++ + +D E +KA
Sbjct: 649 ELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL 708
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ K Q +K+ ++ +K+ + E V I++L A K +E +IS
Sbjct: 709 SEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV-ITTLRTAAKEMEE---KISNLK 764
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTE--IEEKGSLEIANMTELTKKIE 329
LA + + + + S EK + +E + S+ + + E K+ E
Sbjct: 765 EHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKE 824
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRNTASKMKSPWSQ 388
+ QIR +++ + + T K S ++ + L+ + + + ++MK +S+
Sbjct: 825 KVHSEVVQIRSEVSQVKREKENIQTLLK---SKEQEVNELLQKFQQAQEELAEMKR-YSE 880
Query: 389 LSSETLNQDTDKKINK--NEIAKLEMVIQSLNK 419
SS+ L +D DKKIN+ E+ KL+ + SL++
Sbjct: 881 SSSK-LEEDKDKKINEMSKEVTKLKEALNSLSQ 912
>BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 90.2 bits (214), Expect = 5e-17
Identities = 148/762 (19%), Positives = 324/762 (42%), Gaps = 53/762 (6%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+NT+ ++ K Q++L Q+ N+E + L LK ND+ N++
Sbjct: 531 SNTQATPDLLKGQQELTQQTNEETAK---QILYNYLKEGSTD----NDDATKRKVNLVFE 583
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
K LK + N ++ +S E+ L E+ L+ +VAEL+ + LQL + +
Sbjct: 584 KIQ-TLKSRAAGSAQGN-NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQ 638
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA-DIS 648
+ I+ + + +E L SQ + V+E LQQ+ +E E +L ++
Sbjct: 639 N---IKEERERMRANLEEL-----------RSQHNEKVEENSTLQQRLEESEGELRKNLE 684
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIM 707
+L ++ E + + D LS EL ++ K +++ G I++L K+D+
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDEL----DSAKRSEDREKGALIEELLQAKQDLQ 740
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+ L +E DL K E+ L +++ +Q + + DA++Q +E
Sbjct: 741 DLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 799
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ SR E+ A E R L+ + ++L +E ++ ++ Q ++L
Sbjct: 800 TKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + + E ++ ++E +K+ + + + L+ L Q + + ++ +
Sbjct: 860 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 919
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
E ++ + QLR L++ ++ I + +KE+ D+ T S + + L+
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT---STLELQNQLD 976
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
E EKN + +++ QL+E E + ++ + L+++ ++ Q ++
Sbjct: 977 EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQ----DEA 1031
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + L LK + E+ A + ++ +V E K++Q +LE +
Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRS----RLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S+++ S++ E+L+ + ++ ++L+ K++ E + II S
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V L+ +E ++R+ LQ + +L +++E ++Q++ + LT
Sbjct: 1148 VVQMEARIAELEDRLESEE-----RDRANLQLSNRRLERKVKEL---VMQVDDEHLSLTD 1199
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ +K ++E+ E D L S+ +L+ + +D
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 1241
Score = 87.8 bits (208), Expect = 3e-16
Identities = 131/683 (19%), Positives = 298/683 (43%), Gaps = 47/683 (6%)
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLK 686
++++++ +K ++ + A +Q ++Q C+ V L EQ L+ EL ++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQ-GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV 634
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQ 744
+++ + + + + E++ ++ ++EN L +LE+ E K E L ++ E +
Sbjct: 635 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 745 SKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ--- 801
QT+ D + Q +++ E ++ S+ + + +EE + +D + L K +Q
Sbjct: 695 QH-QTEIR-DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752
Query: 802 ------------------LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ S+ QE K +Y + L + + V+ +
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESEST--KYQTQ 899
E + + + ++L EEN+ LQ ++++ L + + D A+++ T KY+ +
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R LE L E + + ++ +LE + +++K L+EK ++ E Q
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAA-QGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELID---KHVQKQQTQSPDYTEQYINEINKLNA 1016
L E +N +L +E+L K ++++ + Q Q +Y E+ E+ ++
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 1017 LLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
LK+K E+ K+ + + DY+ + TK + +E+ ++ + + L+
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LE 1050
Query: 1074 SKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN-VDXX 1131
+K H ++ LV++ +D++ +L E +L E N IS + E M N +
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE--LQECYTKIIQLETLNTELTGHD 1189
+ ++ + + ++ R + E S + + E + + +I +LE E D
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERD 1168
Query: 1190 VVNQEQIN-QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N + N +L+ K+++L + D+ ++ + + +S + ++ E ++ + + E+
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA-EEEIDRLES 1227
Query: 1249 DFQKTEHELRVQLSAFESKYEQL 1271
+K + EL Q+ E QL
Sbjct: 1228 SKKKLQRELEEQMDMNEHLQGQL 1250
Score = 77.4 bits (182), Expect = 4e-13
Identities = 130/703 (18%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+++Q +++ +I +L+E D A+K+++ LV E ++ K + G+ +
Sbjct: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG------ 598
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
N+ N E DL ++ K++ E +A++ + Q +++ Q I +ER+
Sbjct: 599 --NNQACNSTSEVKDLLEQKSKLTIE-----VAELQRQLQLEVKNQQNIK---EERERMR 648
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
N+E S++ ++ +E+ L + ++L E+++ +E +D+L
Sbjct: 649 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
HD E++ + ++ L+EE + L D+ L+ K
Sbjct: 709 EM------HD--------ELDSAKRSEDREKGALIEELLQAKQDLQDL------LIAKEE 748
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDK 943
+ DL K + +L L+ LK H + K KE D E++ +E A ++
Sbjct: 749 QEDLLR----KRERELTALKGALKEEVSSHDQEM-DKLKEQYDAELQALRESVEEATKNV 803
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSP 1001
+VL + + + E +++ + E L EEL + L+ + ++ + ++
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 1002 DYTEQYINEINKLNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++Y EI +L L +++++E ++ + + N + +S + Q + KL+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 1059 N---MEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+E+++R+ ++ + + H + ++ L +E D ++ + + L + + + +
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE--- 980
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ E + +K+Q+E ++E L++ + L +
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE--LRDYQRAQDEALTKRQLL 1038
Query: 1175 IIQLETLNTELTGHDVVNQEQ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
L+ L EL + ++ + Q++ K+ QL E + + L IS + +Q
Sbjct: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME- 1290
EL ++ A+++ + K L Q +S+ L S +SS + +V ME
Sbjct: 1099 EQLRNELLQERAARQDLECDKIS--LERQNKDLKSRIIHLEGSYRSSKE---GLVVQMEA 1153
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
++ L+++L+ +E NLQ + +++ L +++DE ++
Sbjct: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
Score = 75.8 bits (178), Expect = 1e-12
Identities = 130/629 (20%), Positives = 283/629 (44%), Gaps = 75/629 (11%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKS 507
+ +L+ +H + +E S + E E+ K E+L Q ++ E ++DL
Sbjct: 651 LEELRSQHNEKVEENSTLQQRLE-ESEGELRKNLEELFQVKMEREQHQTEIRDL------ 703
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-----LTE 562
++Q+++++DE+D+A ++ + K +L Q ++ + + + ++++R LT
Sbjct: 704 -QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762
Query: 563 ELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
L ++V+ ++E L + + + + R + K + + + + T + + E
Sbjct: 763 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
+ L +E LQ + +E+E ++A + + D E K+ +E + ++L
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA---KETLKKYEGEIRQLEEA 879
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK---------- 731
+ + + ++++ + LEN+ E L QE L++KL++ S +K
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939
Query: 732 ------ISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKY----KSRICR 780
+ + + K+ E ++ ++Q + D Y E EL++ K +
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS-----EYTIQ--EDELVNRLAVLMDH 833
E+S + + ++L Y + + +A + E T++ E EL + + D
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 834 DRVV---EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLA 889
R+V E ++ ++E E +E ++ N LL E + S M+Q N L+ E+A R DL
Sbjct: 1060 SRLVKQMEDKVSQLEMELEE-ERNNSDLLSER--ISRSREQMEQLRNELLQERAARQDL- 1115
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQT----LIVQKKKEIEDLEIEFNTQIESAIRDK-- 943
E + + Q +DL+S + + +++ L+VQ + I +LE ++ES RD+
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE----DRLESEERDRAN 1171
Query: 944 -KVLNEKYEKNI-EYVTQLEAQ---LQEYKN----NIENLNMNVEELNKM--NLELIDKH 992
++ N + E+ + E V Q++ + L + K+ ++ + VEE + LE K
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+Q++ + D E ++N + L+ K
Sbjct: 1232 LQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Score = 72.9 bits (171), Expect = 9e-12
Identities = 133/676 (19%), Positives = 275/676 (40%), Gaps = 64/676 (9%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E + LL+ + ++ L+ +L + I E ++ LE+
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L ++ E E + +EE +++ T+ + L Q+ + + EL++ +
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTE----IRDLQDQLSEMHDELDSAKRSEDR 723
Query: 355 ESKAVSSPSKKGSP-----LISRKSGRNTASKMKSPWSQLSS----ETLNQDTDK-KINK 404
E A+ + LI+++ + K + + L E + D + K+ +
Sbjct: 724 EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE 783
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
A+L+ + +S+ + + E + S +T G + + LQ E+++
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEKLQ---- 835
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
G + E +A++Q Q++ DE K E LK E +I QL + + A K
Sbjct: 836 ----GRSEELERRVAQLQRQIEDLKGDEAKAK------ETLKKYEGEIRQLEEALVHARK 885
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
+ S + +++ N S+ + K++ +E +++ L+ E N + H
Sbjct: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-----LLESQKFDLVQELHILQQKYDE 639
L G+ IE + K+M ++ + T + E + +L + L++K E
Sbjct: 946 L-----GKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTI 696
E ++Q + E + + D ++ L +++L+ + K L
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 697 KDLENDKEDIMNKLQNYIQE---NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG- 752
L ED +++L+ ++E N DL + S E++ +L ++ E ++ +
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119
Query: 753 IDAKIQERDLYIENIESELSKYKSR---ICRLEESIAVMEDRRYSLERKADQL---GSYL 806
I + Q +DL I E S S+ + ++E IA +EDR S ER L L
Sbjct: 1120 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL 1179
Query: 807 QEKQKA--------YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ K K + T Q+D+L RL + E+++ +E K+LQ++ +
Sbjct: 1180 ERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
Query: 859 LEENQNLQISLSDMQQ 874
++ N++LQ L+ M++
Sbjct: 1240 MDMNEHLQGQLNSMKK 1255
Score = 69.7 bits (163), Expect = 8e-11
Identities = 132/692 (19%), Positives = 282/692 (40%), Gaps = 57/692 (8%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N S K +L +K + IE V +L+ QLQ N +N+ E + EL +H
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIE-VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+K + S T Q + + L++ EE+ + + Q + +
Sbjct: 659 NEKVEENS---TLQ--QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + + E + ++LL +KQ ++L I EQ+D +++ +E +LT K E
Sbjct: 714 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK-RERELTALKGALKEEVS 772
Query: 1113 IISSTIEPMSD--DA------NNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSA 1162
++ + + DA +V+ E+++ E V LQE++
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQE-------QINQLKSKLEQLNTENDNLLS 1215
KL +E ++ QL+ +L G + +E +I QL+ L E +S
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L + + +A Q ++ L+++ + + + +LR + E++ L ++
Sbjct: 893 ARRALENELEAA--QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
Query: 1276 QSSTQEETNKIVTMEQVTS--LQNKLQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+ Q+E IV + ++ LQN+L + KE++ R L E Q ++ +E EK
Sbjct: 951 E-KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM------QRQLKEKTLEAEKS 1003
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ E + Y++ Q++++ LK
Sbjct: 1004 RLTAMKMQDEMRL------MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD 1057
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
R + ++ + QLE++ E + + +++ ++ E +R +L++ +DL
Sbjct: 1058 DR-SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Query: 1453 YEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL- 1508
+K E + L+ ++ Y + ++ ++ I EL ++ ES ++ +L
Sbjct: 1117 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL-ESEERDRANLQLS 1175
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVRASSSKIQKHVSFASDT 1564
N+ LE K E+ ++++ + + D+++ ++ V + +I + S
Sbjct: 1176 NRRLER---KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 1232
Query: 1565 KQGRDEQLDNTMNKELLDAVPRAELDLAMYML 1596
++ +EQ+D MN+ L + + DL + L
Sbjct: 1233 QRELEEQMD--MNEHLQGQLNSMKKDLRLKKL 1262
Score = 44.8 bits (101), Expect = 0.003
Identities = 88/487 (18%), Positives = 197/487 (40%), Gaps = 34/487 (6%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-VNQEQINQLKSKL 1203
Q + ++ + L +Q+ + T Q Y + + T N + T V + E+I LKS+
Sbjct: 534 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHE-LRVQL 1261
N+ ++ +E++ + + E+AEL +Q L + K E E +R L
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 651
Query: 1262 SAFESKYEQLLD---SVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
S++ + ++ ++Q +E ++ +E++ ++ + + + +R+LQ++ +++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
Query: 1318 NQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN------I 1370
++++ RSE ++ E+ K+ +E + L +
Sbjct: 712 DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+ + ++ K V +A V L + + + Q E + L Q
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD--QAGTEMRVKLLQE 829
Query: 1431 NDE-----FENVRQQLVEYEKRIEDLTYEKESELAILRL------KMHENANHYETMQKE 1479
+E E + +++ + +++IEDL ++ L+ ++ E H +KE
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ R L EL ++ +L++ L+EE + +++ E E L
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 1540 ITNLQ----NMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYM 1595
I LQ ++V AS + + + + K+ +L M ++L + AE M
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE-MQRQLKEKTLEAEKSRLTAM 1008
Query: 1596 LHQRDVR 1602
Q ++R
Sbjct: 1009 KMQDEMR 1015
>BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 90.2 bits (214), Expect = 5e-17
Identities = 148/762 (19%), Positives = 324/762 (42%), Gaps = 53/762 (6%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+NT+ ++ K Q++L Q+ N+E + L LK ND+ N++
Sbjct: 531 SNTQATPDLLKGQQELTQQTNEETAK---QILYNYLKEGSTD----NDDATKRKVNLVFE 583
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
K LK + N ++ +S E+ L E+ L+ +VAEL+ + LQL + +
Sbjct: 584 KIQ-TLKSRAAGSAQGN-NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQ 638
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA-DIS 648
+ I+ + + +E L SQ + V+E LQQ+ +E E +L ++
Sbjct: 639 N---IKEERERMRANLEEL-----------RSQHNEKVEENSTLQQRLEESEGELRKNLE 684
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIM 707
+L ++ E + + D LS EL ++ K +++ G I++L K+D+
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDEL----DSAKRSEDREKGALIEELLQAKQDLQ 740
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+ L +E DL K E+ L +++ +Q + + DA++Q +E
Sbjct: 741 DLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 799
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ SR E+ A E R L+ + ++L +E ++ ++ Q ++L
Sbjct: 800 TKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + + E ++ ++E +K+ + + + L+ L Q + + ++ +
Sbjct: 860 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 919
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
E ++ + QLR L++ ++ I + +KE+ D+ T S + + L+
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT---STLELQNQLD 976
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
E EKN + +++ QL+E E + ++ + L+++ ++ Q ++
Sbjct: 977 EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQ----DEA 1031
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + L LK + E+ A + ++ +V E K++Q +LE +
Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRS----RLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S+++ S++ E+L+ + ++ ++L+ K++ E + II S
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V L+ +E ++R+ LQ + +L +++E ++Q++ + LT
Sbjct: 1148 VVQMEARIAELEDRLESEE-----RDRANLQLSNRRLERKVKEL---VMQVDDEHLSLTD 1199
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ +K ++E+ E D L S+ +L+ + +D
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 1241
Score = 87.8 bits (208), Expect = 3e-16
Identities = 131/683 (19%), Positives = 298/683 (43%), Gaps = 47/683 (6%)
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLK 686
++++++ +K ++ + A +Q ++Q C+ V L EQ L+ EL ++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQ-GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV 634
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQ 744
+++ + + + + E++ ++ ++EN L +LE+ E K E L ++ E +
Sbjct: 635 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 745 SKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ--- 801
QT+ D + Q +++ E ++ S+ + + +EE + +D + L K +Q
Sbjct: 695 QH-QTEIR-DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752
Query: 802 ------------------LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ S+ QE K +Y + L + + V+ +
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESEST--KYQTQ 899
E + + + ++L EEN+ LQ ++++ L + + D A+++ T KY+ +
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R LE L E + + ++ +LE + +++K L+EK ++ E Q
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAA-QGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELID---KHVQKQQTQSPDYTEQYINEINKLNA 1016
L E +N +L +E+L K ++++ + Q Q +Y E+ E+ ++
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 1017 LLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
LK+K E+ K+ + + DY+ + TK + +E+ ++ + + L+
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LE 1050
Query: 1074 SKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN-VDXX 1131
+K H ++ LV++ +D++ +L E +L E N IS + E M N +
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE--LQECYTKIIQLETLNTELTGHD 1189
+ ++ + + ++ R + E S + + E + + +I +LE E D
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERD 1168
Query: 1190 VVNQEQIN-QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N + N +L+ K+++L + D+ ++ + + +S + ++ E ++ + + E+
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA-EEEIDRLES 1227
Query: 1249 DFQKTEHELRVQLSAFESKYEQL 1271
+K + EL Q+ E QL
Sbjct: 1228 SKKKLQRELEEQMDMNEHLQGQL 1250
Score = 77.4 bits (182), Expect = 4e-13
Identities = 130/703 (18%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+++Q +++ +I +L+E D A+K+++ LV E ++ K + G+ +
Sbjct: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG------ 598
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
N+ N E DL ++ K++ E +A++ + Q +++ Q I +ER+
Sbjct: 599 --NNQACNSTSEVKDLLEQKSKLTIE-----VAELQRQLQLEVKNQQNIK---EERERMR 648
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
N+E S++ ++ +E+ L + ++L E+++ +E +D+L
Sbjct: 649 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
HD E++ + ++ L+EE + L D+ L+ K
Sbjct: 709 EM------HD--------ELDSAKRSEDREKGALIEELLQAKQDLQDL------LIAKEE 748
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDK 943
+ DL K + +L L+ LK H + K KE D E++ +E A ++
Sbjct: 749 QEDLLR----KRERELTALKGALKEEVSSHDQEM-DKLKEQYDAELQALRESVEEATKNV 803
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSP 1001
+VL + + + E +++ + E L EEL + L+ + ++ + ++
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 1002 DYTEQYINEINKLNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++Y EI +L L +++++E ++ + + N + +S + Q + KL+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 1059 N---MEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+E+++R+ ++ + + H + ++ L +E D ++ + + L + + + +
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE--- 980
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ E + +K+Q+E ++E L++ + L +
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE--LRDYQRAQDEALTKRQLL 1038
Query: 1175 IIQLETLNTELTGHDVVNQEQ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
L+ L EL + ++ + Q++ K+ QL E + + L IS + +Q
Sbjct: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME- 1290
EL ++ A+++ + K L Q +S+ L S +SS + +V ME
Sbjct: 1099 EQLRNELLQERAARQDLECDKIS--LERQNKDLKSRIIHLEGSYRSSKE---GLVVQMEA 1153
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
++ L+++L+ +E NLQ + +++ L +++DE ++
Sbjct: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
Score = 75.8 bits (178), Expect = 1e-12
Identities = 130/629 (20%), Positives = 283/629 (44%), Gaps = 75/629 (11%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKS 507
+ +L+ +H + +E S + E E+ K E+L Q ++ E ++DL
Sbjct: 651 LEELRSQHNEKVEENSTLQQRLE-ESEGELRKNLEELFQVKMEREQHQTEIRDL------ 703
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-----LTE 562
++Q+++++DE+D+A ++ + K +L Q ++ + + + ++++R LT
Sbjct: 704 -QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762
Query: 563 ELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
L ++V+ ++E L + + + + R + K + + + + T + + E
Sbjct: 763 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
+ L +E LQ + +E+E ++A + + D E K+ +E + ++L
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA---KETLKKYEGEIRQLEEA 879
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK---------- 731
+ + + ++++ + LEN+ E L QE L++KL++ S +K
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939
Query: 732 ------ISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKY----KSRICR 780
+ + + K+ E ++ ++Q + D Y E EL++ K +
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS-----EYTIQ--EDELVNRLAVLMDH 833
E+S + + ++L Y + + +A + E T++ E EL + + D
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 834 DRVV---EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLA 889
R+V E ++ ++E E +E ++ N LL E + S M+Q N L+ E+A R DL
Sbjct: 1060 SRLVKQMEDKVSQLEMELEE-ERNNSDLLSER--ISRSREQMEQLRNELLQERAARQDL- 1115
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQT----LIVQKKKEIEDLEIEFNTQIESAIRDK-- 943
E + + Q +DL+S + + +++ L+VQ + I +LE ++ES RD+
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE----DRLESEERDRAN 1171
Query: 944 -KVLNEKYEKNI-EYVTQLEAQ---LQEYKN----NIENLNMNVEELNKM--NLELIDKH 992
++ N + E+ + E V Q++ + L + K+ ++ + VEE + LE K
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+Q++ + D E ++N + L+ K
Sbjct: 1232 LQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Score = 72.9 bits (171), Expect = 9e-12
Identities = 133/676 (19%), Positives = 275/676 (40%), Gaps = 64/676 (9%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E + LL+ + ++ L+ +L + I E ++ LE+
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L ++ E E + +EE +++ T+ + L Q+ + + EL++ +
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTE----IRDLQDQLSEMHDELDSAKRSEDR 723
Query: 355 ESKAVSSPSKKGSP-----LISRKSGRNTASKMKSPWSQLSS----ETLNQDTDK-KINK 404
E A+ + LI+++ + K + + L E + D + K+ +
Sbjct: 724 EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE 783
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
A+L+ + +S+ + + E + S +T G + + LQ E+++
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEKLQ---- 835
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
G + E +A++Q Q++ DE K E LK E +I QL + + A K
Sbjct: 836 ----GRSEELERRVAQLQRQIEDLKGDEAKAK------ETLKKYEGEIRQLEEALVHARK 885
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
+ S + +++ N S+ + K++ +E +++ L+ E N + H
Sbjct: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-----LLESQKFDLVQELHILQQKYDE 639
L G+ IE + K+M ++ + T + E + +L + L++K E
Sbjct: 946 L-----GKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTI 696
E ++Q + E + + D ++ L +++L+ + K L
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 697 KDLENDKEDIMNKLQNYIQE---NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG- 752
L ED +++L+ ++E N DL + S E++ +L ++ E ++ +
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119
Query: 753 IDAKIQERDLYIENIESELSKYKSR---ICRLEESIAVMEDRRYSLERKADQL---GSYL 806
I + Q +DL I E S S+ + ++E IA +EDR S ER L L
Sbjct: 1120 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL 1179
Query: 807 QEKQKA--------YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ K K + T Q+D+L RL + E+++ +E K+LQ++ +
Sbjct: 1180 ERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
Query: 859 LEENQNLQISLSDMQQ 874
++ N++LQ L+ M++
Sbjct: 1240 MDMNEHLQGQLNSMKK 1255
Score = 69.7 bits (163), Expect = 8e-11
Identities = 132/692 (19%), Positives = 282/692 (40%), Gaps = 57/692 (8%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N S K +L +K + IE V +L+ QLQ N +N+ E + EL +H
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIE-VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+K + S T Q + + L++ EE+ + + Q + +
Sbjct: 659 NEKVEENS---TLQ--QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + + E + ++LL +KQ ++L I EQ+D +++ +E +LT K E
Sbjct: 714 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK-RERELTALKGALKEEVS 772
Query: 1113 IISSTIEPMSD--DA------NNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSA 1162
++ + + DA +V+ E+++ E V LQE++
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQE-------QINQLKSKLEQLNTENDNLLS 1215
KL +E ++ QL+ +L G + +E +I QL+ L E +S
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L + + +A Q ++ L+++ + + + +LR + E++ L ++
Sbjct: 893 ARRALENELEAA--QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
Query: 1276 QSSTQEETNKIVTMEQVTS--LQNKLQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+ Q+E IV + ++ LQN+L + KE++ R L E Q ++ +E EK
Sbjct: 951 E-KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM------QRQLKEKTLEAEKS 1003
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ E + Y++ Q++++ LK
Sbjct: 1004 RLTAMKMQDEMRL------MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD 1057
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
R + ++ + QLE++ E + + +++ ++ E +R +L++ +DL
Sbjct: 1058 DR-SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Query: 1453 YEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL- 1508
+K E + L+ ++ Y + ++ ++ I EL ++ ES ++ +L
Sbjct: 1117 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL-ESEERDRANLQLS 1175
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVRASSSKIQKHVSFASDT 1564
N+ LE K E+ ++++ + + D+++ ++ V + +I + S
Sbjct: 1176 NRRLER---KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 1232
Query: 1565 KQGRDEQLDNTMNKELLDAVPRAELDLAMYML 1596
++ +EQ+D MN+ L + + DL + L
Sbjct: 1233 QRELEEQMD--MNEHLQGQLNSMKKDLRLKKL 1262
Score = 44.8 bits (101), Expect = 0.003
Identities = 88/487 (18%), Positives = 197/487 (40%), Gaps = 34/487 (6%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-VNQEQINQLKSKL 1203
Q + ++ + L +Q+ + T Q Y + + T N + T V + E+I LKS+
Sbjct: 534 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHE-LRVQL 1261
N+ ++ +E++ + + E+AEL +Q L + K E E +R L
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 651
Query: 1262 SAFESKYEQLLD---SVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
S++ + ++ ++Q +E ++ +E++ ++ + + + +R+LQ++ +++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
Query: 1318 NQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN------I 1370
++++ RSE ++ E+ K+ +E + L +
Sbjct: 712 DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+ + ++ K V +A V L + + + Q E + L Q
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD--QAGTEMRVKLLQE 829
Query: 1431 NDE-----FENVRQQLVEYEKRIEDLTYEKESELAILRL------KMHENANHYETMQKE 1479
+E E + +++ + +++IEDL ++ L+ ++ E H +KE
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ R L EL ++ +L++ L+EE + +++ E E L
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 1540 ITNLQ----NMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYM 1595
I LQ ++V AS + + + + K+ +L M ++L + AE M
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE-MQRQLKEKTLEAEKSRLTAM 1008
Query: 1596 LHQRDVR 1602
Q ++R
Sbjct: 1009 KMQDEMR 1015
>BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 90.2 bits (214), Expect = 5e-17
Identities = 148/762 (19%), Positives = 324/762 (42%), Gaps = 53/762 (6%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+NT+ ++ K Q++L Q+ N+E + L LK ND+ N++
Sbjct: 531 SNTQATPDLLKGQQELTQQTNEETAK---QILYNYLKEGSTD----NDDATKRKVNLVFE 583
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
K LK + N ++ +S E+ L E+ L+ +VAEL+ + LQL + +
Sbjct: 584 KIQ-TLKSRAAGSAQGN-NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQ 638
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA-DIS 648
+ I+ + + +E L SQ + V+E LQQ+ +E E +L ++
Sbjct: 639 N---IKEERERMRANLEEL-----------RSQHNEKVEENSTLQQRLEESEGELRKNLE 684
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIM 707
+L ++ E + + D LS EL ++ K +++ G I++L K+D+
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDEL----DSAKRSEDREKGALIEELLQAKQDLQ 740
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+ L +E DL K E+ L +++ +Q + + DA++Q +E
Sbjct: 741 DLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 799
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ SR E+ A E R L+ + ++L +E ++ ++ Q ++L
Sbjct: 800 TKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + + E ++ ++E +K+ + + + L+ L Q + + ++ +
Sbjct: 860 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 919
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
E ++ + QLR L++ ++ I + +KE+ D+ T S + + L+
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT---STLELQNQLD 976
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
E EKN + +++ QL+E E + ++ + L+++ ++ Q ++
Sbjct: 977 EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQ----DEA 1031
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + L LK + E+ A + ++ +V E K++Q +LE +
Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRS----RLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S+++ S++ E+L+ + ++ ++L+ K++ E + II S
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V L+ +E ++R+ LQ + +L +++E ++Q++ + LT
Sbjct: 1148 VVQMEARIAELEDRLESEE-----RDRANLQLSNRRLERKVKEL---VMQVDDEHLSLTD 1199
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ +K ++E+ E D L S+ +L+ + +D
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 1241
Score = 87.8 bits (208), Expect = 3e-16
Identities = 131/683 (19%), Positives = 298/683 (43%), Gaps = 47/683 (6%)
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLK 686
++++++ +K ++ + A +Q ++Q C+ V L EQ L+ EL ++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQ-GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV 634
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQ 744
+++ + + + + E++ ++ ++EN L +LE+ E K E L ++ E +
Sbjct: 635 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 745 SKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ--- 801
QT+ D + Q +++ E ++ S+ + + +EE + +D + L K +Q
Sbjct: 695 QH-QTEIR-DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752
Query: 802 ------------------LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ S+ QE K +Y + L + + V+ +
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESEST--KYQTQ 899
E + + + ++L EEN+ LQ ++++ L + + D A+++ T KY+ +
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R LE L E + + ++ +LE + +++K L+EK ++ E Q
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAA-QGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELID---KHVQKQQTQSPDYTEQYINEINKLNA 1016
L E +N +L +E+L K ++++ + Q Q +Y E+ E+ ++
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 1017 LLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
LK+K E+ K+ + + DY+ + TK + +E+ ++ + + L+
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LE 1050
Query: 1074 SKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN-VDXX 1131
+K H ++ LV++ +D++ +L E +L E N IS + E M N +
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE--LQECYTKIIQLETLNTELTGHD 1189
+ ++ + + ++ R + E S + + E + + +I +LE E D
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERD 1168
Query: 1190 VVNQEQIN-QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N + N +L+ K+++L + D+ ++ + + +S + ++ E ++ + + E+
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA-EEEIDRLES 1227
Query: 1249 DFQKTEHELRVQLSAFESKYEQL 1271
+K + EL Q+ E QL
Sbjct: 1228 SKKKLQRELEEQMDMNEHLQGQL 1250
Score = 77.4 bits (182), Expect = 4e-13
Identities = 130/703 (18%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+++Q +++ +I +L+E D A+K+++ LV E ++ K + G+ +
Sbjct: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG------ 598
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
N+ N E DL ++ K++ E +A++ + Q +++ Q I +ER+
Sbjct: 599 --NNQACNSTSEVKDLLEQKSKLTIE-----VAELQRQLQLEVKNQQNIK---EERERMR 648
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
N+E S++ ++ +E+ L + ++L E+++ +E +D+L
Sbjct: 649 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
HD E++ + ++ L+EE + L D+ L+ K
Sbjct: 709 EM------HD--------ELDSAKRSEDREKGALIEELLQAKQDLQDL------LIAKEE 748
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDK 943
+ DL K + +L L+ LK H + K KE D E++ +E A ++
Sbjct: 749 QEDLLR----KRERELTALKGALKEEVSSHDQEM-DKLKEQYDAELQALRESVEEATKNV 803
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSP 1001
+VL + + + E +++ + E L EEL + L+ + ++ + ++
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 1002 DYTEQYINEINKLNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++Y EI +L L +++++E ++ + + N + +S + Q + KL+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 1059 N---MEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+E+++R+ ++ + + H + ++ L +E D ++ + + L + + + +
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE--- 980
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ E + +K+Q+E ++E L++ + L +
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE--LRDYQRAQDEALTKRQLL 1038
Query: 1175 IIQLETLNTELTGHDVVNQEQ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
L+ L EL + ++ + Q++ K+ QL E + + L IS + +Q
Sbjct: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME- 1290
EL ++ A+++ + K L Q +S+ L S +SS + +V ME
Sbjct: 1099 EQLRNELLQERAARQDLECDKIS--LERQNKDLKSRIIHLEGSYRSSKE---GLVVQMEA 1153
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
++ L+++L+ +E NLQ + +++ L +++DE ++
Sbjct: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
Score = 75.8 bits (178), Expect = 1e-12
Identities = 130/629 (20%), Positives = 283/629 (44%), Gaps = 75/629 (11%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKS 507
+ +L+ +H + +E S + E E+ K E+L Q ++ E ++DL
Sbjct: 651 LEELRSQHNEKVEENSTLQQRLE-ESEGELRKNLEELFQVKMEREQHQTEIRDL------ 703
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-----LTE 562
++Q+++++DE+D+A ++ + K +L Q ++ + + + ++++R LT
Sbjct: 704 -QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762
Query: 563 ELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
L ++V+ ++E L + + + + R + K + + + + T + + E
Sbjct: 763 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
+ L +E LQ + +E+E ++A + + D E K+ +E + ++L
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA---KETLKKYEGEIRQLEEA 879
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK---------- 731
+ + + ++++ + LEN+ E L QE L++KL++ S +K
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939
Query: 732 ------ISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKY----KSRICR 780
+ + + K+ E ++ ++Q + D Y E EL++ K +
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS-----EYTIQ--EDELVNRLAVLMDH 833
E+S + + ++L Y + + +A + E T++ E EL + + D
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 834 DRVV---EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLA 889
R+V E ++ ++E E +E ++ N LL E + S M+Q N L+ E+A R DL
Sbjct: 1060 SRLVKQMEDKVSQLEMELEE-ERNNSDLLSER--ISRSREQMEQLRNELLQERAARQDL- 1115
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQT----LIVQKKKEIEDLEIEFNTQIESAIRDK-- 943
E + + Q +DL+S + + +++ L+VQ + I +LE ++ES RD+
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE----DRLESEERDRAN 1171
Query: 944 -KVLNEKYEKNI-EYVTQLEAQ---LQEYKN----NIENLNMNVEELNKM--NLELIDKH 992
++ N + E+ + E V Q++ + L + K+ ++ + VEE + LE K
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+Q++ + D E ++N + L+ K
Sbjct: 1232 LQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Score = 72.9 bits (171), Expect = 9e-12
Identities = 133/676 (19%), Positives = 275/676 (40%), Gaps = 64/676 (9%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E + LL+ + ++ L+ +L + I E ++ LE+
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L ++ E E + +EE +++ T+ + L Q+ + + EL++ +
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTE----IRDLQDQLSEMHDELDSAKRSEDR 723
Query: 355 ESKAVSSPSKKGSP-----LISRKSGRNTASKMKSPWSQLSS----ETLNQDTDK-KINK 404
E A+ + LI+++ + K + + L E + D + K+ +
Sbjct: 724 EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE 783
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
A+L+ + +S+ + + E + S +T G + + LQ E+++
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEKLQ---- 835
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
G + E +A++Q Q++ DE K E LK E +I QL + + A K
Sbjct: 836 ----GRSEELERRVAQLQRQIEDLKGDEAKAK------ETLKKYEGEIRQLEEALVHARK 885
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
+ S + +++ N S+ + K++ +E +++ L+ E N + H
Sbjct: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-----LLESQKFDLVQELHILQQKYDE 639
L G+ IE + K+M ++ + T + E + +L + L++K E
Sbjct: 946 L-----GKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTI 696
E ++Q + E + + D ++ L +++L+ + K L
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 697 KDLENDKEDIMNKLQNYIQE---NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG- 752
L ED +++L+ ++E N DL + S E++ +L ++ E ++ +
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119
Query: 753 IDAKIQERDLYIENIESELSKYKSR---ICRLEESIAVMEDRRYSLERKADQL---GSYL 806
I + Q +DL I E S S+ + ++E IA +EDR S ER L L
Sbjct: 1120 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL 1179
Query: 807 QEKQKA--------YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ K K + T Q+D+L RL + E+++ +E K+LQ++ +
Sbjct: 1180 ERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
Query: 859 LEENQNLQISLSDMQQ 874
++ N++LQ L+ M++
Sbjct: 1240 MDMNEHLQGQLNSMKK 1255
Score = 69.7 bits (163), Expect = 8e-11
Identities = 132/692 (19%), Positives = 282/692 (40%), Gaps = 57/692 (8%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N S K +L +K + IE V +L+ QLQ N +N+ E + EL +H
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIE-VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+K + S T Q + + L++ EE+ + + Q + +
Sbjct: 659 NEKVEENS---TLQ--QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + + E + ++LL +KQ ++L I EQ+D +++ +E +LT K E
Sbjct: 714 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK-RERELTALKGALKEEVS 772
Query: 1113 IISSTIEPMSD--DA------NNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSA 1162
++ + + DA +V+ E+++ E V LQE++
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQE-------QINQLKSKLEQLNTENDNLLS 1215
KL +E ++ QL+ +L G + +E +I QL+ L E +S
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L + + +A Q ++ L+++ + + + +LR + E++ L ++
Sbjct: 893 ARRALENELEAA--QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
Query: 1276 QSSTQEETNKIVTMEQVTS--LQNKLQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+ Q+E IV + ++ LQN+L + KE++ R L E Q ++ +E EK
Sbjct: 951 E-KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM------QRQLKEKTLEAEKS 1003
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ E + Y++ Q++++ LK
Sbjct: 1004 RLTAMKMQDEMRL------MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD 1057
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
R + ++ + QLE++ E + + +++ ++ E +R +L++ +DL
Sbjct: 1058 DR-SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Query: 1453 YEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL- 1508
+K E + L+ ++ Y + ++ ++ I EL ++ ES ++ +L
Sbjct: 1117 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL-ESEERDRANLQLS 1175
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVRASSSKIQKHVSFASDT 1564
N+ LE K E+ ++++ + + D+++ ++ V + +I + S
Sbjct: 1176 NRRLER---KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 1232
Query: 1565 KQGRDEQLDNTMNKELLDAVPRAELDLAMYML 1596
++ +EQ+D MN+ L + + DL + L
Sbjct: 1233 QRELEEQMD--MNEHLQGQLNSMKKDLRLKKL 1262
Score = 44.8 bits (101), Expect = 0.003
Identities = 88/487 (18%), Positives = 197/487 (40%), Gaps = 34/487 (6%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-VNQEQINQLKSKL 1203
Q + ++ + L +Q+ + T Q Y + + T N + T V + E+I LKS+
Sbjct: 534 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHE-LRVQL 1261
N+ ++ +E++ + + E+AEL +Q L + K E E +R L
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 651
Query: 1262 SAFESKYEQLLD---SVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
S++ + ++ ++Q +E ++ +E++ ++ + + + +R+LQ++ +++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
Query: 1318 NQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN------I 1370
++++ RSE ++ E+ K+ +E + L +
Sbjct: 712 DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+ + ++ K V +A V L + + + Q E + L Q
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD--QAGTEMRVKLLQE 829
Query: 1431 NDE-----FENVRQQLVEYEKRIEDLTYEKESELAILRL------KMHENANHYETMQKE 1479
+E E + +++ + +++IEDL ++ L+ ++ E H +KE
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ R L EL ++ +L++ L+EE + +++ E E L
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 1540 ITNLQ----NMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYM 1595
I LQ ++V AS + + + + K+ +L M ++L + AE M
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE-MQRQLKEKTLEAEKSRLTAM 1008
Query: 1596 LHQRDVR 1602
Q ++R
Sbjct: 1009 KMQDEMR 1015
>AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein.
Length = 983
Score = 90.2 bits (214), Expect = 5e-17
Identities = 100/500 (20%), Positives = 227/500 (45%), Gaps = 28/500 (5%)
Query: 482 QEQLKQELND---EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
++QL+ EL E+ +N ++ E +++ + + + A K ++ V+ KL L
Sbjct: 455 RKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLV 514
Query: 539 QMQKTIDNFSKVSD---SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+ ++DN+S + + +EI L ++L + ++ +E+ L+ LV+ + G +I+
Sbjct: 515 SPE-SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 573
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL-ADISQLQSDQ 654
V E E + + I + +K L ++ Q++ +++D L + ++Q SD+
Sbjct: 574 PPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDE 629
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
++K + ID L+ EL+ + + + + E Y K LE+ + ++K ++
Sbjct: 630 A-EDMKEA-MNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLEDVTAEYIHKAEH-- 684
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK------IQERDLYIENIE 768
++ M LT+ + + +SE+ ++ + Q + +DA+ I E I +
Sbjct: 685 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLR 744
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ + + +I L+E +A E LE++ + + + + S Y + L + ++
Sbjct: 745 TAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVS 804
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
VL + K+ ++ E +++ + + E +N+Q L +Q N L++K +
Sbjct: 805 VLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQE 864
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
+E +Y LE + + +E + + K+ + L +Q+ + K ++
Sbjct: 865 ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSL-----SQLSYSTSSSKRQSQ 919
Query: 949 KYEKNIEYVTQLEAQLQEYK 968
+ E + V QL+ QL E K
Sbjct: 920 QLEALQQQVKQLQNQLAECK 939
Score = 69.3 bits (162), Expect = 1e-10
Identities = 113/549 (20%), Positives = 251/549 (45%), Gaps = 49/549 (8%)
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL----L 619
+H L + + + LQ L D R+ S+ +K +++E L R + + L +
Sbjct: 420 IHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVE-LQSRRAELVCLNNTEI 477
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-----LQSDQVCSEIKSVH-LEEQIDALSA 673
DL Q+L Q KY+E ++ + + L S + H L + ++
Sbjct: 478 SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV 537
Query: 674 SKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNK-LQNYIQENMDLTDKLEKMSAEK 731
K++L +E + +KE++ + L E +K ++ ++ Y + +E M+ EK
Sbjct: 538 LKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEK 597
Query: 732 ISELLAKINHEEQS------KIQTQFGIDAKIQERDLY--IENIESELSKYKSRICRL-E 782
+ L K ++ +++Q +A + D+ + + EL+K S + +L +
Sbjct: 598 -AFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYK 656
Query: 783 ESIAVMED--RRYSLERKADQLGSYLQ--EKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E+ A +ED +R SLE D Y+ E +K + + + L+ + V
Sbjct: 657 EAQAELEDYRKRKSLE---DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 713
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+L +++ + + QK+N + + E+ LQ+ ++ ++ + EK + +L E ++K +
Sbjct: 714 NELTQLK-QLVDAQKENSVSITEH--LQV-ITTLRTAAKEMEEKIS--NLKEHLASK-EV 766
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES-AIRDKKVLNEKYEKNIEYV 957
++ LE L T + + E L+ +++ A + K+ + EK EK V
Sbjct: 767 EVAKLEKQLLE-EKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK-EKVHSEV 824
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
Q+ +++ + K EN+ ++ + EL+ K Q Q+ + ++Y +KL
Sbjct: 825 VQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAE--MKRYAESSSKLE-- 880
Query: 1018 LKQKDEEIIALNQKINNAQ--VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD-S 1074
+ KD++I +++++ + ++ +S +S S + + +LE ++++++++ QL +
Sbjct: 881 -EDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK 939
Query: 1075 KQHNEELQI 1083
KQH E + +
Sbjct: 940 KQHQEVISV 948
Score = 57.2 bits (132), Expect = 5e-07
Identities = 104/527 (19%), Positives = 215/527 (40%), Gaps = 52/527 (9%)
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E +L L+ + E++ LN N ++S S SD KL + +K E +E+ V K
Sbjct: 454 ERKQLQVELQSRRAELVCLN----NTEISENS--SDLSQKLKETQSKYEEAMKEVLSVQK 507
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNV 1128
Q+ +L ++ E D E ++T E +N+ K + E + +
Sbjct: 508 QM--------KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVREL 559
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQER--SVLQ---EQSAKLNTELQECYTKIIQL-ETLN 1182
+ EE E ++ SV++ ++ A L + QE +I++L +TL
Sbjct: 560 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 619
Query: 1183 TELTGHDVVNQEQINQLKSKL-EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+++T E + + +++ ++LN + L E ++ + ++ E
Sbjct: 620 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 679
Query: 1242 HLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQS-----STQEETNKIVT--MEQ 1291
H A+ E Q T + LS +S+Y ++L+ + Q+E + +T ++
Sbjct: 680 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 739
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+T+L+ ++ EE + NL+E A ++ L ++ +EK A D
Sbjct: 740 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM---------------TD 784
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKS-SXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
SY+++Q ++ ++LK+S R ++ K + Q
Sbjct: 785 AMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 844
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
LK E Q+ +E Q +E ++ + E ++E+ +K +E++ K+ E
Sbjct: 845 LKSKE--QEVNELLQKFQQAQEELAEMK-RYAESSSKLEEDKDKKINEMSKEVTKLKEAL 901
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
N + + + + ++L + L Q+AE K +E ++
Sbjct: 902 NSLSQLSYSTSSSK-RQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 947
Score = 52.0 bits (119), Expect = 2e-05
Identities = 105/565 (18%), Positives = 239/565 (42%), Gaps = 64/565 (11%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIMNKLQNYIQENMDLTD 722
L++++++ A +K+L + +++ + + L T I + +D + + Q+ +E M
Sbjct: 444 LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVL 503
Query: 723 KLEK-MSAEKIS-ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
++K M +S E + +H + ++ + + + ++DL +N E + K ++
Sbjct: 504 SVQKQMKLGLVSPESMDNYSHFHELRVTEE---EINVLKQDL--QNALEESERNKEKVRE 558
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
LEE + E K + ++E ++ S Y + + A L + + +++
Sbjct: 559 LEEKLVERE--------KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEE 610
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+++++ K+Q+ E + + DM++ N ++++ N+ S Y+
Sbjct: 611 IMKLKDT-----LKSQMTQEASDEAE----DMKEAMNRMIDELNKQ--VSELSQLYKEAQ 659
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+LE KR + E T K E E L N A + +Y K + +TQL
Sbjct: 660 AELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL 719
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
+ + K N ++ +++ + L K ++++ + ++ E+ KL KQ
Sbjct: 720 KQLVDAQKENSVSITEHLQVIT--TLRTAAKEMEEKISNLKEHLASKEVEVAKLE---KQ 774
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
EE A+ + + SY + S ES+++ +KL+ +E ++V H+E
Sbjct: 775 LLEEKAAMTDAMV-PRSSYEKLQSSLESEVSVLASKLKESVKEKEKV---------HSEV 824
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+QI R + Q+K KE T + K++ ++ ++
Sbjct: 825 VQI--RSEVSQVKREKENIQT----LLKSKEQEVNELLQKFQQAQE-------------- 864
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
++ E + + + S L+E K E+ + TK+ + ++L+ ++ Q QL+
Sbjct: 865 --ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 922
Query: 1201 SKLEQLNTENDNLLSTVAELRSSIS 1225
+ +Q+ + L + + IS
Sbjct: 923 ALQQQVKQLQNQLAECKKQHQEVIS 947
Score = 43.2 bits (97), Expect = 0.008
Identities = 80/449 (17%), Positives = 172/449 (38%), Gaps = 35/449 (7%)
Query: 1175 IIQLETLNTELTGHDV-VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSI----SSAVD 1229
++ E+++ H++ V +E+IN LK L+ E++ V EL + V
Sbjct: 513 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI 572
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS-TQEETNKIVT 1288
+ E E K + K + L + + + +L D+++S TQE +++
Sbjct: 573 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 632
Query: 1289 MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXXXX 1346
M++ ++ + + + + L + Y + ++E R +ED +
Sbjct: 633 MKE--AMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQL 690
Query: 1347 XXXXDLRTENQ-SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+ E+ S + Q +LN + QL + + E+
Sbjct: 691 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEM 750
Query: 1406 THQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
++ + K E Q +E + +V E L ESE+++L K
Sbjct: 751 EEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP-RSSYEKLQSSLESEVSVLASK 809
Query: 1466 MHENAN-----HYETMQKESEIERVK--------LI----EELNVKITESVSLNKQVAEL 1508
+ E+ H E +Q SE+ +VK L+ +E+N + + +++AE+
Sbjct: 810 LKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEM 869
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+ E + + E+ L + + +L + ++SS K S + Q +
Sbjct: 870 KRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS--SKRQSQQLEALQQQ 927
Query: 1569 DEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+QL N +L + + + +++Y +H
Sbjct: 928 VKQLQN----QLAECKKQHQEVISVYRMH 952
Score = 33.1 bits (72), Expect = 8.5
Identities = 66/333 (19%), Positives = 134/333 (40%), Gaps = 23/333 (6%)
Query: 94 LANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT-IK 152
+ N K+K L EK ++ +E I++ + D+ N I
Sbjct: 590 IENMNKEKAFLFEKYQEAQE-------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 642
Query: 153 EKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKAT-TXXXXXXXXXXXXXXXXX 211
E + +S L K + + D +++ + +D E +KA
Sbjct: 643 ELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL 702
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ K Q +K+ ++ +K+ + E V I++L A K +E +IS
Sbjct: 703 SEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV-ITTLRTAAKEMEE---KISNLK 758
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTE--IEEKGSLEIANMTELTKKIE 329
LA + + + + S EK + +E + S+ + + E K+ E
Sbjct: 759 EHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKE 818
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRNTASKMKSPWSQ 388
+ QIR +++ + + T K S ++ + L+ + + + ++MK +++
Sbjct: 819 KVHSEVVQIRSEVSQVKREKENIQTLLK---SKEQEVNELLQKFQQAQEELAEMKR-YAE 874
Query: 389 LSSETLNQDTDKKINK--NEIAKLEMVIQSLNK 419
SS+ L +D DKKIN+ E+ KL+ + SL++
Sbjct: 875 SSSK-LEEDKDKKINEMSKEVTKLKEALNSLSQ 906
>AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein.
Length = 1302
Score = 90.2 bits (214), Expect = 5e-17
Identities = 148/762 (19%), Positives = 324/762 (42%), Gaps = 53/762 (6%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+NT+ ++ K Q++L Q+ N+E + L LK ND+ N++
Sbjct: 531 SNTQATPDLLKGQQELTQQTNEETAK---QILYNYLKEGSTD----NDDATKRKVNLVFE 583
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
K LK + N ++ +S E+ L E+ L+ +VAEL+ + LQL + +
Sbjct: 584 KIQ-TLKSRAAGSAQGN-NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQ 638
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA-DIS 648
+ I+ + + +E L SQ + V+E LQQ+ +E E +L ++
Sbjct: 639 N---IKEERERMRANLEEL-----------RSQHNEKVEENSTLQQRLEESEGELRKNLE 684
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIM 707
+L ++ E + + D LS EL ++ K +++ G I++L K+D+
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDEL----DSAKRSEDREKGALIEELLQAKQDLQ 740
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+ L +E DL K E+ L +++ +Q + + DA++Q +E
Sbjct: 741 DLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 799
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ SR E+ A E R L+ + ++L +E ++ ++ Q ++L
Sbjct: 800 TKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + + E ++ ++E +K+ + + + L+ L Q + + ++ +
Sbjct: 860 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 919
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
E ++ + QLR L++ ++ I + +KE+ D+ T S + + L+
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT---STLELQNQLD 976
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
E EKN + +++ QL+E E + ++ + L+++ ++ Q ++
Sbjct: 977 EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQ----DEA 1031
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + L LK + E+ A + ++ +V E K++Q +LE +
Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRS----RLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S+++ S++ E+L+ + ++ ++L+ K++ E + II S
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V L+ +E ++R+ LQ + +L +++E ++Q++ + LT
Sbjct: 1148 VVQMEARIAELEDRLESEE-----RDRANLQLSNRRLERKVKEL---VMQVDDEHLSLTD 1199
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ +K ++E+ E D L S+ +L+ + +D
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 1241
Score = 87.8 bits (208), Expect = 3e-16
Identities = 131/683 (19%), Positives = 298/683 (43%), Gaps = 47/683 (6%)
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLK 686
++++++ +K ++ + A +Q ++Q C+ V L EQ L+ EL ++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQ-GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV 634
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQ 744
+++ + + + + E++ ++ ++EN L +LE+ E K E L ++ E +
Sbjct: 635 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 745 SKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ--- 801
QT+ D + Q +++ E ++ S+ + + +EE + +D + L K +Q
Sbjct: 695 QH-QTEIR-DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752
Query: 802 ------------------LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ S+ QE K +Y + L + + V+ +
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESEST--KYQTQ 899
E + + + ++L EEN+ LQ ++++ L + + D A+++ T KY+ +
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R LE L E + + ++ +LE + +++K L+EK ++ E Q
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAA-QGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELID---KHVQKQQTQSPDYTEQYINEINKLNA 1016
L E +N +L +E+L K ++++ + Q Q +Y E+ E+ ++
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 1017 LLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
LK+K E+ K+ + + DY+ + TK + +E+ ++ + + L+
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LE 1050
Query: 1074 SKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN-VDXX 1131
+K H ++ LV++ +D++ +L E +L E N IS + E M N +
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE--LQECYTKIIQLETLNTELTGHD 1189
+ ++ + + ++ R + E S + + E + + +I +LE E D
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERD 1168
Query: 1190 VVNQEQIN-QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N + N +L+ K+++L + D+ ++ + + +S + ++ E ++ + + E+
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA-EEEIDRLES 1227
Query: 1249 DFQKTEHELRVQLSAFESKYEQL 1271
+K + EL Q+ E QL
Sbjct: 1228 SKKKLQRELEEQMDMNEHLQGQL 1250
Score = 77.4 bits (182), Expect = 4e-13
Identities = 130/703 (18%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+++Q +++ +I +L+E D A+K+++ LV E ++ K + G+ +
Sbjct: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG------ 598
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
N+ N E DL ++ K++ E +A++ + Q +++ Q I +ER+
Sbjct: 599 --NNQACNSTSEVKDLLEQKSKLTIE-----VAELQRQLQLEVKNQQNIK---EERERMR 648
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
N+E S++ ++ +E+ L + ++L E+++ +E +D+L
Sbjct: 649 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
HD E++ + ++ L+EE + L D+ L+ K
Sbjct: 709 EM------HD--------ELDSAKRSEDREKGALIEELLQAKQDLQDL------LIAKEE 748
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDK 943
+ DL K + +L L+ LK H + K KE D E++ +E A ++
Sbjct: 749 QEDLLR----KRERELTALKGALKEEVSSHDQEM-DKLKEQYDAELQALRESVEEATKNV 803
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSP 1001
+VL + + + E +++ + E L EEL + L+ + ++ + ++
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 1002 DYTEQYINEINKLNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++Y EI +L L +++++E ++ + + N + +S + Q + KL+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 1059 N---MEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+E+++R+ ++ + + H + ++ L +E D ++ + + L + + + +
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE--- 980
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ E + +K+Q+E ++E L++ + L +
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE--LRDYQRAQDEALTKRQLL 1038
Query: 1175 IIQLETLNTELTGHDVVNQEQ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
L+ L EL + ++ + Q++ K+ QL E + + L IS + +Q
Sbjct: 1039 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME- 1290
EL ++ A+++ + K L Q +S+ L S +SS + +V ME
Sbjct: 1099 EQLRNELLQERAARQDLECDKIS--LERQNKDLKSRIIHLEGSYRSSKE---GLVVQMEA 1153
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
++ L+++L+ +E NLQ + +++ L +++DE ++
Sbjct: 1154 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
Score = 75.8 bits (178), Expect = 1e-12
Identities = 130/629 (20%), Positives = 283/629 (44%), Gaps = 75/629 (11%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKS 507
+ +L+ +H + +E S + E E+ K E+L Q ++ E ++DL
Sbjct: 651 LEELRSQHNEKVEENSTLQQRLE-ESEGELRKNLEELFQVKMEREQHQTEIRDL------ 703
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-----LTE 562
++Q+++++DE+D+A ++ + K +L Q ++ + + + ++++R LT
Sbjct: 704 -QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762
Query: 563 ELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
L ++V+ ++E L + + + + R + K + + + + T + + E
Sbjct: 763 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
+ L +E LQ + +E+E ++A + + D E K+ +E + ++L
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA---KETLKKYEGEIRQLEEA 879
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK---------- 731
+ + + ++++ + LEN+ E L QE L++KL++ S +K
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939
Query: 732 ------ISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKY----KSRICR 780
+ + + K+ E ++ ++Q + D Y E EL++ K +
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS-----EYTIQ--EDELVNRLAVLMDH 833
E+S + + ++L Y + + +A + E T++ E EL + + D
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 834 DRVV---EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLA 889
R+V E ++ ++E E +E ++ N LL E + S M+Q N L+ E+A R DL
Sbjct: 1060 SRLVKQMEDKVSQLEMELEE-ERNNSDLLSER--ISRSREQMEQLRNELLQERAARQDL- 1115
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQT----LIVQKKKEIEDLEIEFNTQIESAIRDK-- 943
E + + Q +DL+S + + +++ L+VQ + I +LE ++ES RD+
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE----DRLESEERDRAN 1171
Query: 944 -KVLNEKYEKNI-EYVTQLEAQ---LQEYKN----NIENLNMNVEELNKM--NLELIDKH 992
++ N + E+ + E V Q++ + L + K+ ++ + VEE + LE K
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+Q++ + D E ++N + L+ K
Sbjct: 1232 LQRELEEQMDMNEHLQGQLNSMKKDLRLK 1260
Score = 72.9 bits (171), Expect = 9e-12
Identities = 133/676 (19%), Positives = 275/676 (40%), Gaps = 64/676 (9%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E + LL+ + ++ L+ +L + I E ++ LE+
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L ++ E E + +EE +++ T+ + L Q+ + + EL++ +
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTE----IRDLQDQLSEMHDELDSAKRSEDR 723
Query: 355 ESKAVSSPSKKGSP-----LISRKSGRNTASKMKSPWSQLSS----ETLNQDTDK-KINK 404
E A+ + LI+++ + K + + L E + D + K+ +
Sbjct: 724 EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE 783
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
A+L+ + +S+ + + E + S +T G + + LQ E+++
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEKLQ---- 835
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
G + E +A++Q Q++ DE K E LK E +I QL + + A K
Sbjct: 836 ----GRSEELERRVAQLQRQIEDLKGDEAKAK------ETLKKYEGEIRQLEEALVHARK 885
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
+ S + +++ N S+ + K++ +E +++ L+ E N + H
Sbjct: 886 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-----LLESQKFDLVQELHILQQKYDE 639
L G+ IE + K+M ++ + T + E + +L + L++K E
Sbjct: 946 L-----GKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTI 696
E ++Q + E + + D ++ L +++L+ + K L
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 697 KDLENDKEDIMNKLQNYIQE---NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG- 752
L ED +++L+ ++E N DL + S E++ +L ++ E ++ +
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119
Query: 753 IDAKIQERDLYIENIESELSKYKSR---ICRLEESIAVMEDRRYSLERKADQL---GSYL 806
I + Q +DL I E S S+ + ++E IA +EDR S ER L L
Sbjct: 1120 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL 1179
Query: 807 QEKQKA--------YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ K K + T Q+D+L RL + E+++ +E K+LQ++ +
Sbjct: 1180 ERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
Query: 859 LEENQNLQISLSDMQQ 874
++ N++LQ L+ M++
Sbjct: 1240 MDMNEHLQGQLNSMKK 1255
Score = 69.7 bits (163), Expect = 8e-11
Identities = 132/692 (19%), Positives = 282/692 (40%), Gaps = 57/692 (8%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N S K +L +K + IE V +L+ QLQ N +N+ E + EL +H
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIE-VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+K + S T Q + + L++ EE+ + + Q + +
Sbjct: 659 NEKVEENS---TLQ--QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + + E + ++LL +KQ ++L I EQ+D +++ +E +LT K E
Sbjct: 714 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK-RERELTALKGALKEEVS 772
Query: 1113 IISSTIEPMSD--DA------NNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSA 1162
++ + + DA +V+ E+++ E V LQE++
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQE-------QINQLKSKLEQLNTENDNLLS 1215
KL +E ++ QL+ +L G + +E +I QL+ L E +S
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L + + +A Q ++ L+++ + + + +LR + E++ L ++
Sbjct: 893 ARRALENELEAA--QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
Query: 1276 QSSTQEETNKIVTMEQVTS--LQNKLQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+ Q+E IV + ++ LQN+L + KE++ R L E Q ++ +E EK
Sbjct: 951 E-KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM------QRQLKEKTLEAEKS 1003
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ E + Y++ Q++++ LK
Sbjct: 1004 RLTAMKMQDEMRL------MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD 1057
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
R + ++ + QLE++ E + + +++ ++ E +R +L++ +DL
Sbjct: 1058 DR-SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Query: 1453 YEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL- 1508
+K E + L+ ++ Y + ++ ++ I EL ++ ES ++ +L
Sbjct: 1117 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL-ESEERDRANLQLS 1175
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVRASSSKIQKHVSFASDT 1564
N+ LE K E+ ++++ + + D+++ ++ V + +I + S
Sbjct: 1176 NRRLER---KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 1232
Query: 1565 KQGRDEQLDNTMNKELLDAVPRAELDLAMYML 1596
++ +EQ+D MN+ L + + DL + L
Sbjct: 1233 QRELEEQMD--MNEHLQGQLNSMKKDLRLKKL 1262
Score = 44.8 bits (101), Expect = 0.003
Identities = 88/487 (18%), Positives = 197/487 (40%), Gaps = 34/487 (6%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-VNQEQINQLKSKL 1203
Q + ++ + L +Q+ + T Q Y + + T N + T V + E+I LKS+
Sbjct: 534 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHE-LRVQL 1261
N+ ++ +E++ + + E+AEL +Q L + K E E +R L
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 651
Query: 1262 SAFESKYEQLLD---SVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
S++ + ++ ++Q +E ++ +E++ ++ + + + +R+LQ++ +++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
Query: 1318 NQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN------I 1370
++++ RSE ++ E+ K+ +E + L +
Sbjct: 712 DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+ + ++ K V +A V L + + + Q E + L Q
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD--QAGTEMRVKLLQE 829
Query: 1431 NDE-----FENVRQQLVEYEKRIEDLTYEKESELAILRL------KMHENANHYETMQKE 1479
+E E + +++ + +++IEDL ++ L+ ++ E H +KE
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ R L EL ++ +L++ L+EE + +++ E E L
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 1540 ITNLQ----NMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYM 1595
I LQ ++V AS + + + + K+ +L M ++L + AE M
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE-MQRQLKEKTLEAEKSRLTAM 1008
Query: 1596 LHQRDVR 1602
Q ++R
Sbjct: 1009 KMQDEMR 1015
>AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment
epithelial cell protein protein.
Length = 980
Score = 90.2 bits (214), Expect = 5e-17
Identities = 100/500 (20%), Positives = 227/500 (45%), Gaps = 28/500 (5%)
Query: 482 QEQLKQELND---EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
++QL+ EL E+ +N ++ E +++ + + + A K ++ V+ KL L
Sbjct: 452 RKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLV 511
Query: 539 QMQKTIDNFSKVSD---SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+ ++DN+S + + +EI L ++L + ++ +E+ L+ LV+ + G +I+
Sbjct: 512 SPE-SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 570
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL-ADISQLQSDQ 654
V E E + + I + +K L ++ Q++ +++D L + ++Q SD+
Sbjct: 571 PPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDE 626
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
++K + ID L+ EL+ + + + + E Y K LE+ + ++K ++
Sbjct: 627 A-EDMKEA-MNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLEDVTAEYIHKAEH-- 681
Query: 715 QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK------IQERDLYIENIE 768
++ M LT+ + + +SE+ ++ + Q + +DA+ I E I +
Sbjct: 682 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLR 741
Query: 769 SELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLA 828
+ + + +I L+E +A E LE++ + + + + S Y + L + ++
Sbjct: 742 TAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVS 801
Query: 829 VLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDL 888
VL + K+ ++ E +++ + + E +N+Q L +Q N L++K +
Sbjct: 802 VLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQE 861
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNE 948
+E +Y LE + + +E + + K+ + L +Q+ + K ++
Sbjct: 862 ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSL-----SQLSYSTSSSKRQSQ 916
Query: 949 KYEKNIEYVTQLEAQLQEYK 968
+ E + V QL+ QL E K
Sbjct: 917 QLEALQQQVKQLQNQLAECK 936
Score = 69.3 bits (162), Expect = 1e-10
Identities = 113/549 (20%), Positives = 251/549 (45%), Gaps = 49/549 (8%)
Query: 564 LHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL----L 619
+H L + + + LQ L D R+ S+ +K +++E L R + + L +
Sbjct: 417 IHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVE-LQSRRAELVCLNNTEI 474
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQ-----LQSDQVCSEIKSVH-LEEQIDALSA 673
DL Q+L Q KY+E ++ + + L S + H L + ++
Sbjct: 475 SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINV 534
Query: 674 SKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNK-LQNYIQENMDLTDKLEKMSAEK 731
K++L +E + +KE++ + L E +K ++ ++ Y + +E M+ EK
Sbjct: 535 LKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEK 594
Query: 732 ISELLAKINHEEQS------KIQTQFGIDAKIQERDLY--IENIESELSKYKSRICRL-E 782
+ L K ++ +++Q +A + D+ + + EL+K S + +L +
Sbjct: 595 -AFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYK 653
Query: 783 ESIAVMED--RRYSLERKADQLGSYLQ--EKQKAYSEYTIQEDELVNRLAVLMDHDRVVE 838
E+ A +ED +R SLE D Y+ E +K + + + L+ + V
Sbjct: 654 EAQAELEDYRKRKSLE---DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 710
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+L +++ + + QK+N + + E+ LQ+ ++ ++ + EK + +L E ++K +
Sbjct: 711 NELTQLK-QLVDAQKENSVSITEH--LQV-ITTLRTAAKEMEEKIS--NLKEHLASK-EV 763
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES-AIRDKKVLNEKYEKNIEYV 957
++ LE L T + + E L+ +++ A + K+ + EK EK V
Sbjct: 764 EVAKLEKQLLE-EKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK-EKVHSEV 821
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
Q+ +++ + K EN+ ++ + EL+ K Q Q+ + ++Y +KL
Sbjct: 822 VQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAE--MKRYAESSSKLE-- 877
Query: 1018 LKQKDEEIIALNQKINNAQ--VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD-S 1074
+ KD++I +++++ + ++ +S +S S + + +LE ++++++++ QL +
Sbjct: 878 -EDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK 936
Query: 1075 KQHNEELQI 1083
KQH E + +
Sbjct: 937 KQHQEVISV 945
Score = 57.2 bits (132), Expect = 5e-07
Identities = 104/527 (19%), Positives = 215/527 (40%), Gaps = 52/527 (9%)
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E +L L+ + E++ LN N ++S S SD KL + +K E +E+ V K
Sbjct: 451 ERKQLQVELQSRRAELVCLN----NTEISENS--SDLSQKLKETQSKYEEAMKEVLSVQK 504
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMIISSTIEPMSDDANNV 1128
Q+ +L ++ E D E ++T E +N+ K + E + +
Sbjct: 505 QM--------KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVREL 556
Query: 1129 DXXXXXXXXXXXXLKVQEEEEFIQER--SVLQ---EQSAKLNTELQECYTKIIQL-ETLN 1182
+ EE E ++ SV++ ++ A L + QE +I++L +TL
Sbjct: 557 EEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLK 616
Query: 1183 TELTGHDVVNQEQINQLKSKL-EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
+++T E + + +++ ++LN + L E ++ + ++ E
Sbjct: 617 SQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI 676
Query: 1242 HLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQS-----STQEETNKIVT--MEQ 1291
H A+ E Q T + LS +S+Y ++L+ + Q+E + +T ++
Sbjct: 677 HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV 736
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+T+L+ ++ EE + NL+E A ++ L ++ +EK A D
Sbjct: 737 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM---------------TD 781
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKS-SXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
SY+++Q ++ ++LK+S R ++ K + Q
Sbjct: 782 AMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL 841
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
LK E Q+ +E Q +E ++ + E ++E+ +K +E++ K+ E
Sbjct: 842 LKSKE--QEVNELLQKFQQAQEELAEMK-RYAESSSKLEEDKDKKINEMSKEVTKLKEAL 898
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
N + + + + ++L + L Q+AE K +E ++
Sbjct: 899 NSLSQLSYSTSSSK-RQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Score = 52.0 bits (119), Expect = 2e-05
Identities = 105/565 (18%), Positives = 239/565 (42%), Gaps = 64/565 (11%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIMNKLQNYIQENMDLTD 722
L++++++ A +K+L + +++ + + L T I + +D + + Q+ +E M
Sbjct: 441 LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVL 500
Query: 723 KLEK-MSAEKIS-ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
++K M +S E + +H + ++ + + + ++DL +N E + K ++
Sbjct: 501 SVQKQMKLGLVSPESMDNYSHFHELRVTEE---EINVLKQDL--QNALEESERNKEKVRE 555
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
LEE + E K + ++E ++ S Y + + A L + + +++
Sbjct: 556 LEEKLVERE--------KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEE 607
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+++++ K+Q+ E + + DM++ N ++++ N+ S Y+
Sbjct: 608 IMKLKDT-----LKSQMTQEASDEAE----DMKEAMNRMIDELNKQ--VSELSQLYKEAQ 656
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+LE KR + E T K E E L N A + +Y K + +TQL
Sbjct: 657 AELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL 716
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
+ + K N ++ +++ + L K ++++ + ++ E+ KL KQ
Sbjct: 717 KQLVDAQKENSVSITEHLQVIT--TLRTAAKEMEEKISNLKEHLASKEVEVAKLE---KQ 771
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
EE A+ + + SY + S ES+++ +KL+ +E ++V H+E
Sbjct: 772 LLEEKAAMTDAMV-PRSSYEKLQSSLESEVSVLASKLKESVKEKEKV---------HSEV 821
Query: 1081 LQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+QI R + Q+K KE T + K++ ++ ++
Sbjct: 822 VQI--RSEVSQVKREKENIQT----LLKSKEQEVNELLQKFQQAQE-------------- 861
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
++ E + + + S L+E K E+ + TK+ + ++L+ ++ Q QL+
Sbjct: 862 --ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 919
Query: 1201 SKLEQLNTENDNLLSTVAELRSSIS 1225
+ +Q+ + L + + IS
Sbjct: 920 ALQQQVKQLQNQLAECKKQHQEVIS 944
Score = 43.2 bits (97), Expect = 0.008
Identities = 80/449 (17%), Positives = 172/449 (38%), Gaps = 35/449 (7%)
Query: 1175 IIQLETLNTELTGHDV-VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSI----SSAVD 1229
++ E+++ H++ V +E+IN LK L+ E++ V EL + V
Sbjct: 510 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI 569
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS-TQEETNKIVT 1288
+ E E K + K + L + + + +L D+++S TQE +++
Sbjct: 570 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 629
Query: 1289 MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXXXX 1346
M++ ++ + + + + L + Y + ++E R +ED +
Sbjct: 630 MKE--AMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQL 687
Query: 1347 XXXXDLRTENQ-SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLEL 1405
+ E+ S + Q +LN + QL + + E+
Sbjct: 688 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEM 747
Query: 1406 THQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLK 1465
++ + K E Q +E + +V E L ESE+++L K
Sbjct: 748 EEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP-RSSYEKLQSSLESEVSVLASK 806
Query: 1466 MHENAN-----HYETMQKESEIERVK--------LI----EELNVKITESVSLNKQVAEL 1508
+ E+ H E +Q SE+ +VK L+ +E+N + + +++AE+
Sbjct: 807 LKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEM 866
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGR 1568
+ E + + E+ L + + +L + ++SS K S + Q +
Sbjct: 867 KRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS--SKRQSQQLEALQQQ 924
Query: 1569 DEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
+QL N +L + + + +++Y +H
Sbjct: 925 VKQLQN----QLAECKKQHQEVISVYRMH 949
Score = 33.1 bits (72), Expect = 8.5
Identities = 66/333 (19%), Positives = 134/333 (40%), Gaps = 23/333 (6%)
Query: 94 LANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNT-IK 152
+ N K+K L EK ++ +E I++ + D+ N I
Sbjct: 587 IENMNKEKAFLFEKYQEAQE-------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 639
Query: 153 EKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKAT-TXXXXXXXXXXXXXXXXX 211
E + +S L K + + D +++ + +D E +KA
Sbjct: 640 ELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL 699
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ K Q +K+ ++ +K+ + E V I++L A K +E +IS
Sbjct: 700 SEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQV-ITTLRTAAKEMEE---KISNLK 755
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTE--IEEKGSLEIANMTELTKKIE 329
LA + + + + S EK + +E + S+ + + E K+ E
Sbjct: 756 EHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKE 815
Query: 330 LLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRNTASKMKSPWSQ 388
+ QIR +++ + + T K S ++ + L+ + + + ++MK +++
Sbjct: 816 KVHSEVVQIRSEVSQVKREKENIQTLLK---SKEQEVNELLQKFQQAQEELAEMKR-YAE 871
Query: 389 LSSETLNQDTDKKINK--NEIAKLEMVIQSLNK 419
SS+ L +D DKKIN+ E+ KL+ + SL++
Sbjct: 872 SSSK-LEEDKDKKINEMSKEVTKLKEALNSLSQ 903
>AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring protein
AKAP350 protein.
Length = 3595
Score = 90.2 bits (214), Expect = 5e-17
Identities = 160/818 (19%), Positives = 358/818 (43%), Gaps = 84/818 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQI 512
QLEH + + + ++ E K QE+L++ L++E + + L +L AE I
Sbjct: 1555 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR--AREQLAVELSKAEGVI 1612
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
DE + I+ K++ +L+Q N ++ + E ++ EE LS++
Sbjct: 1613 DGYADE-KTLFERQIQEKTDIIDRLEQELLCASN--RLQELEAEQQQIQEERELLSRQKE 1669
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
++ E G ++ L+ E E L + +L+ E + DL +++
Sbjct: 1670 AMKAEAGPVEQQLLQ----------------ETEKLMKEKLEVQCQAEKDRDDLQKQVKA 1713
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+ +VE++++ +L+ ++ + + L +Q AL +++ ++ +D+E
Sbjct: 1714 LE---IDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH- 1766
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKIQTQF 751
+ D+ + +++ + + + + +S + E+ NH +E++ ++
Sbjct: 1767 ----------ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 1816
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ + +RD+ N E+ K + R+ LE+++ V D +E + G+ ++ K +
Sbjct: 1817 LLSKEQLQRDIQERN--EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHFGA-VEAKPE 1872
Query: 812 AYSEYTIQ--EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
E +Q D + + + + + +E+ E+E++N+E+Q+ + L + + L
Sbjct: 1873 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 1932
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDL 928
+++Q + + LA ES TQ + L +I E + I Q +++ L
Sbjct: 1933 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 1992
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ Q D KV+ EK E + TQ+E + + + N +E+LN++ +E
Sbjct: 1993 Q-----QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV-IEK 2046
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN--NAQVSYM-SMVSD 1045
+ + + ++ E + L L E +AL Q++ N ++++M +++ +
Sbjct: 2047 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2106
Query: 1046 YESKLAQFTTKLENMEEEMQRVSK-QLLDSKQHNEELQILVREQ--------DDQIKELK 1096
K+ Q T +L +++ E + V K Q + N + L +++ +D +K L
Sbjct: 2107 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL- 2165
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
E + F+ +G II+ + + A +++ + Q E E +Q
Sbjct: 2166 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2225
Query: 1153 ER-----SVLQEQSA-----KLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQI--NQL 1199
++ +++E+ A ++ E + Y K Q +T+++E ++ N Q+ ++L
Sbjct: 2226 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2285
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
S + L L S V E+ +S+ +++ EIAE
Sbjct: 2286 GSDISALTLRISELESQVVEMHTSL--ILEKEQVEIAE 2321
Score = 89.0 bits (211), Expect = 1e-16
Identities = 146/761 (19%), Positives = 333/761 (43%), Gaps = 67/761 (8%)
Query: 860 EENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
E+++ ++ S + Q ++E+ N T + E E K +L+D + ++ E Q IV
Sbjct: 1 EQDKKVENSNKEEIQEKETIIEELN-TKIIEEE--KKTLELKDKLTTADKLLGELQEQIV 57
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
QK +EI+++++E + + + + + E + Q + ++ + +
Sbjct: 58 QKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQ 117
Query: 980 -ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL--NQKINNAQ 1036
+L ++ EL + + Q+ + Q++ ++ ++ K + E + N +N Q
Sbjct: 118 RKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQ 177
Query: 1037 VSYMSM-VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ M++ +++ KL ++ E ++EE+ + ++ ++ E+L + +QI+
Sbjct: 178 IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRA 237
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
++T E + + + ST+E + + L+++ E E +
Sbjct: 238 RQTIAEQESKLNEAHKSL--STVEDLKAEI-------VSASESRKELELKHEAEVTNYKI 288
Query: 1156 VLQEQSAKLNTELQE-CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE---QLNTEN- 1210
L+ + N L ++ +LE L T+L ++E++++LK LE ++N E
Sbjct: 289 KLEMLEKEKNAVLDRMAESQEAELERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKL 345
Query: 1211 -DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR-VQLSAFESKY 1268
DNL + + + + Q+ E + K +L ++ +L+ +Q S SK
Sbjct: 346 KDNLGIHYKQQIDGLQNEMSQK-IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 404
Query: 1269 EQL---LDSVQSST----QEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIE 1321
E++ ++ +Q QEE K ++V LQ K + E+ ++ + + Q+E
Sbjct: 405 EEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE 464
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL--RTENQSYKQMQEQSILNINEENAQLKK 1379
S ++DEK +++S + E+ I + EEN LK+
Sbjct: 465 AENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 524
Query: 1380 SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQ 1439
+ AE K E+ +Q EL++ EY L ++D ++ +
Sbjct: 525 QCIQLNEEIEKQRNTFSFAE-KNFEVNYQ-ELQE--------EYACLLKVKDDLEDSKNK 574
Query: 1440 QLVEYEKRI----EDLTYEKESELAI-LRLKMHENANHY--ETMQKESEIER--VKLIEE 1490
Q +EY+ ++ E+L ++ + + ++ + + + ET++ +E+ +L+E+
Sbjct: 575 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 634
Query: 1491 LNVKITESVSLNKQVAELNKALE----------EEV--AKTNEMQTALENQEIEIVTLND 1538
L V E + L++++++L++ L+ EEV K + Q +L +E+EI+ ++
Sbjct: 635 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 694
Query: 1539 EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
N+Q+ SS + V+ S +G +++ + +E
Sbjct: 695 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 735
Score = 88.6 bits (210), Expect = 2e-16
Identities = 177/942 (18%), Positives = 395/942 (41%), Gaps = 61/942 (6%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
+ N ++ N ++V + ++K+M I +L K+ + + E +
Sbjct: 161 MENALRSYSN-ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ 219
Query: 207 XXXXXED---TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA 263
E+ +++Q+ + ++ E++ +E + L +E I S E+ K LE
Sbjct: 220 LEDLVEELSFSREQIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELEL- 277
Query: 264 RFEISLEHSKLAQEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEE-KGSLEIA 319
+ E + + K+ E+ E+ L + + + E+ + K LEI
Sbjct: 278 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 337
Query: 320 NMTELTK-KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISR-KSGRN 377
+ + K K L H QI E+ K+ TM E + + + IS+ K +
Sbjct: 338 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 397
Query: 378 TASKMKSPWSQLSSETLNQDTD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXX 436
+ KS L L ++ + + + E LE +Q L E + EK+
Sbjct: 398 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 457
Query: 437 XXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDV 496
+++++ + ++ +E IH + E E + +K + D + +
Sbjct: 458 EKFAQLEAENSILK----DEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWEK 510
Query: 497 NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE 556
++ LIE+ + ++Q QLN+EI+ + N ++ +++Q+ KV D + E
Sbjct: 511 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLE 569
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
+ +EL + S K+ L EE L L ++ + +M +S V+ + + +AET L+
Sbjct: 570 DSKNKQELEYKS-KLKALNEE---LHLQRINPTTVKM-KSSVFDE--DKTFVAET-LEMG 621
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKK 676
++E +L+++L + +++ E+ +L+D+S+ Q Q EI L E++ +L K+
Sbjct: 622 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEIS--FLNEEVKSLKQEKE 678
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+++L L++ + +++++ + + L + +T + + S K+++
Sbjct: 679 QVSLRCRELEIIIN--HNRAENVQSCDTQVSSLLDGVV----TMTSRGAEGSVSKVNKSF 732
Query: 737 ---AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
+KI E++ + + + ++ L ++++ S + R + E+ + ++
Sbjct: 733 GEESKIMVEDKVSFE-NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV 791
Query: 794 SLERKADQLGSYLQEKQKAYS-EYTIQEDELVNRLAVLMDHD--RVVEKQLLEIEHENKE 850
L+ + + L ++ ++ S Y+ D++ + D + E+ + E + KE
Sbjct: 792 -LKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 850
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE---------SESTKYQTQLR 901
LQK +Q+ L+ + + D + + L+ K + E S +Y T
Sbjct: 851 LQKIHQLELQTMKTQE--TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 908
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLE 961
E N + + + + E++D E E+ + E+Y K + T+L
Sbjct: 909 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL- 967
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+++ + + L E L K E + H Q T D + ++++ L L K K
Sbjct: 968 SKIWGQQTDGMKLEFGEENLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSLQDLEKTK 1025
Query: 1022 -DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEE 1062
+E++ L I++ Q +YE+++ +L+ + E
Sbjct: 1026 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1067
Score = 85.0 bits (201), Expect = 2e-15
Identities = 179/902 (19%), Positives = 390/902 (43%), Gaps = 91/902 (10%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAANKNMIKV-KSNHKLKLKQMQKTIDNFSKVSDSNKEI 557
++ E LK EE +L++E A + +++ K+ + +KT+ ++ + I
Sbjct: 1575 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFE-RQIQEKTDII 1633
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQ--LHLVDYDSGRM-IESDVYKKMI--EMENLAETR 612
RL +EL S ++ ELE E+ +Q L+ M E+ ++ + E E L + +
Sbjct: 1634 DRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEK 1693
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS 672
L+ E + DL +++ L+ +E + ++ Q ++ ++ + L +Q AL
Sbjct: 1694 LEVQCQAEKDRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL------MDLRQQNQALE 1747
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKI 732
+++ ++ +D+E + E + + + + T ++E++ A +
Sbjct: 1748 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL-ANHL 1806
Query: 733 SELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
E K + SK Q Q IQER+ IE +E + + + + ++ +EDR+
Sbjct: 1807 KEKTDKCSELLLSKEQLQ----RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRK 1862
Query: 793 Y--SLERKAD-QLGSYLQEKQKAYS----EYTIQEDELVNRLAVLMDHDRVVEKQLLEIE 845
+ ++E K + L LQ ++ A E T E++L L + + V++ +++E
Sbjct: 1863 HFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE 1922
Query: 846 HENKE-------LQKKNQILLEENQNLQISLSDMQ----QHYNALVEK-ANRTDLAESES 893
+ KE L+++N++ ++ + L +++ + Q + L K A E E
Sbjct: 1923 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 1982
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
+ Q+ L+ LK IT +++ +I +K + I DLE TQIE + D++ + E+
Sbjct: 1983 DQLNEQVTKLQQQLK-ITTDNK-VIEEKNELIRDLE----TQIECLMSDQECVKRNREEE 2036
Query: 954 IEYVTQLEAQLQEYKNNI-ENLNMNVEELNK--------MNLELIDKHVQKQQTQSPDYT 1004
IE + ++ +LQ+ NI + +MN L++ +++ + +K +QQ ++ +
Sbjct: 2037 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE 2096
Query: 1005 EQYI-NEINKLNALLKQKDEEIIALN------QKINNAQVSYMSMVSDYESK----LAQF 1053
++ N + + N + Q +E+ +L +KI + + +++ D+ SK L
Sbjct: 2097 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV 2156
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQH---NEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
T+ E Q K ++ + N E ++L E K+L+ T+ ++ + +
Sbjct: 2157 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2216
Query: 1111 GMIISSTIEPMSDDANN-VDXXXXXXXXXXXXLK-VQEEEEFIQERSVLQEQSAKLN--- 1165
G + ++ + V+ L+ VQE +F Q+ + + + N
Sbjct: 2217 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2276
Query: 1166 ----------TELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL---EQLNTENDN 1212
+++ +I +LE+ E+ ++ +EQ+ + + E+ E
Sbjct: 2277 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2336
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHL-AQREADFQKTEHELRVQLSAFESKYEQL 1271
LL + + + E+ + + + E+ F LR + A +++
Sbjct: 2337 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2396
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ + QEE +V +TSLQ L +HL +EK + + + E +E+++ K
Sbjct: 2397 KEKAEK-LQEEL--LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE---TEVQESK 2450
Query: 1332 VA 1333
A
Sbjct: 2451 KA 2452
Score = 82.6 bits (195), Expect = 1e-14
Identities = 273/1391 (19%), Positives = 557/1391 (40%), Gaps = 116/1391 (8%)
Query: 221 MQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAA--RFEISLEHSKLAQEL 278
+Q+ A+E + +++ R ++ + K+ + L + N+ LE + L+ + +E
Sbjct: 1707 LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 1766
Query: 279 EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELL-EHLNCQ 337
E+ +P E +T E+ + + T+ ++ L E L
Sbjct: 1767 ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 1826
Query: 338 IRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKS-GRNTASKMKSPWSQLSSETLNQ 396
I++ N+E+E + +A+ + + RK G A S QL +E
Sbjct: 1827 IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE--RD 1884
Query: 397 DTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
D+K + EI LE ++ ++L +K + + + + Q
Sbjct: 1885 AIDRK--EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLF 1942
Query: 457 QQHMEGPSLI---HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT 513
+ ME L +T+D + + Q+ QE EI +N + + KL+ + +IT
Sbjct: 1943 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN--EQVTKLQQ-QLKIT 1999
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKEIVRLTEELHHLSQKVA 572
N I+ N+ + +++ + + + N + + N+ I +L +EL ++ QK +
Sbjct: 2000 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2059
Query: 573 ----ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFD-LV 627
L EE +L+ H +D + E ++ +E N T +K + + K + L
Sbjct: 2060 MNAHSLSEEADSLK-HQLDVV---IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLT 2115
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI--ENL 685
QEL L+++ + VE K+ I + SV++ ID LS K EL +V+ + L
Sbjct: 2116 QELFSLKRERESVE-KIQSIPE----------NSVNVA--IDHLSKDKPELEVVLTEDAL 2162
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK-LEKMSAEKISELLAKINHEEQ 744
K + Q Y + EN K I+N +Q ++ K LE K + + + E
Sbjct: 2163 KSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 2221
Query: 745 SKIQTQFGIDAKIQERDL---YIENIESELSKYKSRICRLEESIAVMEDRRYSLER---- 797
+Q + KI E + + I+ E + ++ C+ ++I+ E R +++
Sbjct: 2222 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS-SEPERTNIQNLNQL 2280
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
+ D+LGS + SE Q E+ L + + + EK +LE E + ELQK
Sbjct: 2281 REDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK---- 2336
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
LLE N+ Q + + V K +E + + +L L + E +
Sbjct: 2337 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2396
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
+ +K E+L ++ T + S +D + + + E ++ LE +E + ++
Sbjct: 2397 KEKAEKLQEELLVK-ETNMTSLQKDLSQVRDHLAEAKEKLSILE---KEDETEVQ----- 2447
Query: 978 VEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQV 1037
E E + + K D T + I+ N+ +L + I L + ++ +V
Sbjct: 2448 -ESKKACMFEPLPIKLSKSIASQTDGTLK-ISSSNQTPQILVKNAGIQINLQSECSSEEV 2505
Query: 1038 SYMSMVSDYESKLAQFTT--KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ ++S + K+ + E ++ E + +S+ ++H +Q+L +E+ +K +
Sbjct: 2506 T--EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLL-KEECGTLKAV 2562
Query: 1096 KETKLTFE-MNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
+ + E +IP+ T E S D+ + D + E +
Sbjct: 2563 IQCLRSKEGSSIPELAHSDAYQTREICSSDSGS-DWGQGIYLTHSQGFDIASEGRGEESE 2621
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
S K+ L+ + + +Q+ +L TE D I Q+ E E +
Sbjct: 2622 SATDSFPKKIKGLLRAVHNEGMQVLSL-TESPYSDG-EDHSIQQVS---EPWLEERKAYI 2676
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLS-AFESKYEQLLD 1273
+T++ L+ I+ QR E+ + + H F EL + L F + LL
Sbjct: 2677 NTISSLKDLITKMQLQREAEVYDSSQSH-----ESFSDWRGELLLALQQVFLEERSVLLA 2731
Query: 1274 SVQSS-TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQE--KYAD---VINQIEILRSEI 1327
+ ++ T T V + + L+ ++Q++ + E + AD ++++I+ L +++
Sbjct: 2732 AFRTELTALGTTDAVGL--LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 2789
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
K+ +++ + +MQ + + ++ + +L++
Sbjct: 2790 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE-LSSMKDRATELQEQLSSEKMV 2848
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKR 1447
+ A+ K LEL L+ + + ++ + + + + DE + L +K+
Sbjct: 2849 VAELKSEL--AQTK-LELETTLKAQHKHL-KELEAFRLEVKDKTDEVHLLNDTLASEQKK 2904
Query: 1448 IEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
+L + E E A L E KE +E+L + N Q
Sbjct: 2905 SRELQWALEKEKAKL--------GRSEERDKEE-------LEDLKFSLESQKQRNLQ--- 2946
Query: 1508 LNKALEEEVAKTNEMQTALENQEI--EIVTLNDEITNLQNMVRASSSKIQ-KHVSFASDT 1564
LN LE++ NE Q +E+Q + + ++ NL+ V S K++ + +S D
Sbjct: 2947 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3006
Query: 1565 KQGRDEQLDNT 1575
++ QL ++
Sbjct: 3007 ERELHAQLQSS 3017
Score = 71.7 bits (168), Expect = 2e-11
Identities = 191/975 (19%), Positives = 397/975 (40%), Gaps = 107/975 (10%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALS----ASKKELALVIENLKLD 688
LQ++ + +LA S + ++ + SE + V LEE ++AL A +++L + N
Sbjct: 1316 LQEEIKRLNRQLAQRSSIDNENLVSERERVLLEE-LEALKQLSLAGREKLCCELRNSSTQ 1374
Query: 689 KE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
+ + G +++ ++++ K ++ E + E+ + +K + L KI E
Sbjct: 1375 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL----SNERYALQKANNRLLKILLE--- 1427
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV---MEDRRYSLERKADQL 802
++T ++ I L I + S+ S I R E +V + + E
Sbjct: 1428 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRDESIPSYS 1487
Query: 803 GSYLQEKQ-KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIE-HENKELQKKNQILLE 860
GS + +S+ T + EL RL ++ + E+ + + LQ + LLE
Sbjct: 1488 GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLE 1547
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L + L+ ++ R +ES K Q +LR+ R+ HE Q
Sbjct: 1548 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRE------RL-HEESRAREQ 1600
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE 980
E+ E I+ +K + + ++ + + +LE +L N ++ L ++
Sbjct: 1601 LAVELSKAE----GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1656
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYM 1040
+ + EL+ + + + ++ +Q + E K L+K+K E + ++ Q
Sbjct: 1657 IQE-ERELLSRQKEAMKAEAGPVEQQLLQETEK---LMKEKLEVQCQAEKDRDDLQKQVK 1712
Query: 1041 SMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ----DDQIKELK 1096
++ D E ++++F +LE Q + +L+D +Q N+ L+ + + D+Q + +
Sbjct: 1713 ALEIDVEEQVSRF-IELE------QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE 1765
Query: 1097 ETKLTFEMNIPKTEGMI-ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
+ F+ I K E + + +P+S+ K + E + +
Sbjct: 1766 HERDVFQQEIQKLEQQLKVVPRFQPISEH----QTREVEQLANHLKEKTDKCSELLLSKE 1821
Query: 1156 VLQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLE-----QLNT 1208
LQ + N E+++ ++ +LE L + T V +++ +++K E QL
Sbjct: 1822 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA 1881
Query: 1209 ENDNL------LSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLS 1262
E D + ++ + E ++ + E+ +L Q Q++ + + EL +
Sbjct: 1882 ERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENK 1940
Query: 1263 AFESKYEQL-LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIE 1321
F+ E+L L +S ++ V + + +Q+KE + L E+ + Q++
Sbjct: 1941 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI---IQEKEVEIDQLNEQVTKLQQQLK 1997
Query: 1322 ILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSS 1381
I D KV L ++ + K+ +E+ I +NE +L++
Sbjct: 1998 I----TTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2051
Query: 1382 XXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
+++ EA L HQL++ +E + L Q
Sbjct: 2052 ANIGQKTSMNAHSLSE-EAD--SLKHQLDVVIAE--------KLALEQ------------ 2088
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE-IERVKLIEELNVKITESVS 1500
+ E E++T+ K + L KM++ ++++E E +E+++ I E +V +
Sbjct: 2089 -QVETANEEMTFMK-NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID-H 2145
Query: 1501 LNKQVAELNKALEEEVAKTNEMQTAL----ENQEIEIVTLNDEITNLQNMVRASSSKI-Q 1555
L+K EL L E+ K+ E QT EN + I+ L + L++ V A ++ Q
Sbjct: 2146 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2205
Query: 1556 KHVSFASDTKQGRDE 1570
+ +QG+ E
Sbjct: 2206 CYKQIKDMQEQGQFE 2220
Score = 63.7 bits (148), Expect = 5e-09
Identities = 209/1161 (18%), Positives = 473/1161 (40%), Gaps = 101/1161 (8%)
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK-VKSNHKLK 536
++K+ Q + E + N+ + S Q+T L D ID +K+ + ++ K K
Sbjct: 967 LSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLED-IDVNHKSKLSSLQDLEKTK 1025
Query: 537 LKQMQKTIDNF-SKVSDSNKEIVRLTE-ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
L++ + +++ S + KE + E E+H L +++ + E L + DS +
Sbjct: 1026 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPV---DSVVIT 1082
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI---LQQKYDE-VEDKLADISQL 650
ESD + M + + I S +F + +E +I L+++Y E +E+++A +
Sbjct: 1083 ESDAQRTMYPGSCVKKNIDGTIEF--SGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVS 1140
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL 710
S + + + + ++SK+ A+ +EQ Y L D+
Sbjct: 1141 MSIAFAQQTELSRISGGKENTASSKQAHAVC------QQEQHYFNEMKLSQDQIGF---- 1190
Query: 711 QNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESE 770
Q + ++ ++ + +S E + E H ++ + D + +D + E
Sbjct: 1191 QTFETVDVKFKEEFKPLSKE-LGE------HGKEILLSNSDPHDIP-ESKDCVLTISEEM 1242
Query: 771 LSKYKSRICR--LEESIAVME-DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
SK K+ I R + + I+V D L +QL QE + Y E+ Q EL+ +
Sbjct: 1243 FSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ-QATELLRQA 1301
Query: 828 AVL-MDHDRVVEKQLLE-IEHENKELQKKN------------QILLEENQNL-QISLSDM 872
+ M+ R ++QL E I+ N++L +++ ++LLEE + L Q+SL+
Sbjct: 1302 HMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGR 1361
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQ-LRDLESNLKR-------ITHEHQTLIVQKKKE 924
++ L + +T + + Q ++ E + K +++E L +
Sbjct: 1362 EKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRL 1421
Query: 925 IEDL-EIEFNTQIESAIRDKKVL-----NEKYEKNIEYV--TQLEAQLQEYKNNIENLNM 976
++ L E+ T + VL + K + + + ++ EA ++ + +
Sbjct: 1422 LKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRDE 1481
Query: 977 NVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA-LNQKINNA 1035
++ + ++ D ++ + T+ Q + + ++EE++ ++ ++ A
Sbjct: 1482 SIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA 1541
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ +S+ S+L + E R ++ +S + EEL+ + E+ ++L
Sbjct: 1542 VEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQL 1601
Query: 1096 --KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
+ +K ++ E + I+ +D + ++ L+ E+++ +E
Sbjct: 1602 AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA-EQQQIQEE 1660
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
R +L Q + E +++Q E L E ++ + L+ +++ L + +
Sbjct: 1661 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKDRDDLQKQVKALEIDVEE 1720
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
+S EL ++ E+ +L +Q+ A E +K L Q A + ++E+ +
Sbjct: 1721 QVSRFIELEQ-------EKNTELMDLRQQNQAL-EKQLEKMRKFLDEQ--AIDREHERDV 1770
Query: 1273 DSVQSSTQEETNKIVTMEQVTSLQN--KLQDKEEHLRNLQEKYADVINQIEILRSEIED- 1329
+ E+ K+V Q S +++ HL+ +K ++++ E L+ +I++
Sbjct: 1771 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 1830
Query: 1330 ----EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXX 1385
EK+ F + + + ++ + L++ E Q ++ +
Sbjct: 1831 NEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSL-EVQLQAERDAIDRK 1889
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYE 1445
+ + E ++ + +LE K+ E+ Q + I + + + Q+ ++
Sbjct: 1890 EK------EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 1943
Query: 1446 KRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN-----VKITESVS 1500
+E L + A+ H + + +E E+E +L E++ +KIT
Sbjct: 1944 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2003
Query: 1501 LNKQVAELNKALEEEV-AKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVS 1559
+ ++ EL + LE ++ ++ + N+E EI LN+ I LQ + K +
Sbjct: 2004 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2063
Query: 1560 FASDTKQGRDEQLDNTMNKEL 1580
S+ QLD + ++L
Sbjct: 2064 SLSEEADSLKHQLDVVIAEKL 2084
Score = 58.4 bits (135), Expect = 2e-07
Identities = 93/502 (18%), Positives = 206/502 (41%), Gaps = 36/502 (7%)
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
+N ++ L D ++ K L+ E E + + ++ + L ++L + +++ A
Sbjct: 2676 INTISSLKD---LITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 2732
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI--VQKK------KEIEDLEIEFNTQ 935
RT+L +T L LE ++ E+Q + +QK EI+ L + N +
Sbjct: 2733 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 2792
Query: 936 IESAIRDK---KVLNEKYEKNIEY----VTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ R++ K E E NI+ + +++ +L K+ L + + EL
Sbjct: 2793 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 2852
Query: 989 IDKHVQKQQTQSPDYTEQY--INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+ Q + Q+ + E+ +K K +E+ LN + + Q +
Sbjct: 2853 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 2912
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
E + A+ E +EE++ + L KQ N +L +L+ +Q + E ++ ++ +
Sbjct: 2913 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 2972
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS- 1161
+ + + +G + + S+ + ++Q + Q R L +
Sbjct: 2973 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3032
Query: 1162 -AKLNTELQECYTKIIQL--ET----LNTELTGHDVVNQEQINQLKSKLEQ-LNTENDNL 1213
+L +L+E +++I++L ET L++ T + Q+++ + EQ NTE
Sbjct: 3033 LKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKK 3092
Query: 1214 LSTVAELRSSISSAVDQRGFEI--AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+ + + ++++ ++ +L Q L +FQK E E + + Y+ L
Sbjct: 3093 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3152
Query: 1272 LD-SVQSSTQEETNKIVTMEQV 1292
+ + S T + T V +++
Sbjct: 3153 NEPTTWSLTSDRTRNWVLQQKI 3174
Score = 55.2 bits (127), Expect = 2e-06
Identities = 146/750 (19%), Positives = 326/750 (43%), Gaps = 73/750 (9%)
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKSVHLEEQ 667
E R I+ + S K DL+ ++ + Q+ EV D ++ ++ V LEE+
Sbjct: 2670 EERKAYINTISSLK-DLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEER 2726
Query: 668 IDALSASKKEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
L+A + EL AL + L I++ + + M LQ + L +++
Sbjct: 2727 SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSEIQA 2784
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ A+ + + E++S+ +Q ++ IQ++ + ++ ELS K R L+E ++
Sbjct: 2785 LHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 2843
Query: 787 ----VMEDRRYSLERKADQLGSYLQEKQKAYSE---YTIQEDELVNRLAVLMDHDRVVEK 839
V+ + + L + +L + L+ + K E + ++ + + + +L D +K
Sbjct: 2844 SEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK 2903
Query: 840 QLLE----IEHENKELQKKNQILLEENQNLQISLSDMQQ---HYNALVEKANR-----TD 887
+ E +E E +L + + EE ++L+ SL +Q N L+E+ +
Sbjct: 2904 KSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 2963
Query: 888 LAESESTKYQTQLRDLES-NLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
ES+ Y QL + + NL+ ++ E + + +++ D E E + Q++S+ D
Sbjct: 2964 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS--DGTG 3021
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+ + + + +L+ QL+E + I L +N E K++ L + ++ Q T
Sbjct: 3022 QSRPPLPSEDLLKELQKQLEEKHSRIVEL-LNETEKYKLD-SLQTRQQMEKDRQVHRKTL 3079
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
Q E N + +++ L K+ + Q + + ++ + + + ++ MQ
Sbjct: 3080 QTEQEAN------TEGQKKMHELQSKVEDLQ----RQLEEKRQQVYKLDLEGQRLQGIMQ 3129
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
KQ L+ ++ E +IL + ++ T+ + +T ++ IE + ++
Sbjct: 3130 EFQKQELEREEKRESRRILYQNLNE--------PTTWSLTSDRTRNWVLQQKIEGETKES 3181
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N E E I+++ LQ ++KL L + ++ +Q ET + E
Sbjct: 3182 NYAKLIEMNGGGTG----CNHELEMIRQK--LQCVASKLQV-LPQKASERLQFETADDE- 3233
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ QE I+++ +L++L + S V+ +S S ++ + AEL H++Q
Sbjct: 3234 --DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTERLLRQNAEL-TGHISQ 3289
Query: 1246 READFQKTEHELRVQLSAFESK---YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+ +++LR + E + Y Q +S++ N +E + + + ++ ++
Sbjct: 3290 ----LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNR 3345
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
E+ LQ+ ++ L++E+ ++ +
Sbjct: 3346 EK--LTLQKSLKRAEAEVYKLKAELRNDSL 3373
Score = 52.4 bits (120), Expect = 1e-05
Identities = 158/800 (19%), Positives = 328/800 (41%), Gaps = 81/800 (10%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANK-LLEAARFEISLEHSK 273
KQQ+ +Q + EK L+ + IS L++ + L+ + E++L+ ++
Sbjct: 354 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 413
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEH 333
L +E+E +Q ++ + KTE+ EK E N +L +K LE
Sbjct: 414 LQKEIE-----ILRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKEN--DLQEKFAQLEA 465
Query: 334 LNCQIRQTNKELENKL---ATMGTESKAV--SSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
N ++ K LE+ L + E + + S K + K + + Q
Sbjct: 466 ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 525
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEY--VISEKDTXXXXXXXXXXGKD 446
LN++ +K+ N A+ + N + +EY ++ KD
Sbjct: 526 CIQ--LNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDLEDSKNKQELEYK 580
Query: 447 TLIAQLQLEHQQHMEGPSLIHVGTNTEDVN--------EIAKVQEQLKQELNDEIKDVNV 498
+ + L E P+ + + ++ D + E+ +V E+ EL ++++
Sbjct: 581 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 640
Query: 499 K--DLIEKLKSAEEQITQLNDEIDAAN---KNMIKVKSNHKLKLKQMQKTIDN--FSKVS 551
+ +L ++L EQ+ Q + EI N K++ + K L+ ++++ I++ V
Sbjct: 641 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 700
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV-YKKMI-----EM 605
+ ++ L + + ++ + AE K N +S M+E V ++ M +
Sbjct: 701 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF---GEESKIMVEDKVSFENMTVGEESKQ 757
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS-QLQSDQVC-SEIKSVH 663
E L L +++ S + E LQ++ + ++ + D+ Q+++ ++C S + S H
Sbjct: 758 EQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTH 817
Query: 664 LEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL-- 720
+++ + + K K L + E L +E+ ++ + + M K Q E L
Sbjct: 818 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHL 876
Query: 721 -TDKLEKMSAEKISELL----AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
KL+K +E+ S L + + ++ + + K D EN + EL Y+
Sbjct: 877 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 936
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMD 832
+ +E++ + ++ K L + L + +Q + E+ L +
Sbjct: 937 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 996
Query: 833 -HDRVVEKQLLEIEHENK--ELQKKNQILLEEN--------QNLQISLSDMQQHYNALVE 881
H ++ + +++ H++K LQ + LEE +LQ L + +Q+Y A +
Sbjct: 997 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIH 1056
Query: 882 KANRTDLAESESTKYQTQLRD----LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-- 935
+ A SEST + D ES+ +R + + KK I D IEF+ +
Sbjct: 1057 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCV----KKNI-DGTIEFSGEFG 1111
Query: 936 IESAIRDKKVLNEKYEKNIE 955
++ K+L ++Y++ +E
Sbjct: 1112 VKEETNIVKLLEKQYQEQLE 1131
Score = 35.1 bits (77), Expect = 2.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 13/153 (8%)
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYE-TMQKESEIERVKL-IEELN 1492
+ +++Q VEY+ +E L L +H N + T+++E E E+ + E N
Sbjct: 2754 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 2813
Query: 1493 VKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVR 1548
++ +S L QV EL+ + + E+Q L ++++ + L E+ L+ ++
Sbjct: 2814 IQQKQSQMLEMQV-ELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLK 2868
Query: 1549 ASSSKIQKHVSFASDTKQGRDE--QLDNTMNKE 1579
A +++ +F + K DE L++T+ E
Sbjct: 2869 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 2901
>BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein.
Length = 1726
Score = 89.8 bits (213), Expect = 7e-17
Identities = 206/1030 (20%), Positives = 429/1030 (41%), Gaps = 101/1030 (9%)
Query: 339 RQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDT 398
R+ NKE + + + K V S K+ R S + S + S L+ L D
Sbjct: 613 RKENKEYASSGPAL--QMKEVKSTEKE-----KRTSKESVNSPVFGKASLLTGGLLQVDD 665
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
D +++ + + ++ N+ K + S D +D +L H
Sbjct: 666 DSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDC-----ELPHSS 720
Query: 459 HMEGPSLIH-VGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
+ LI +G +D + K+Q+ L E E+K + + L K+K E+++ L
Sbjct: 721 YKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQ 780
Query: 517 DEIDAAN--KNMI---KVKSNHKL-----KLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
E+ K+ + KV+ +L L Q ++ N + + +E +R EE +
Sbjct: 781 RELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYR 840
Query: 567 LSQKVA---ELEEEKGNLQLHLVDYDSGRMIE--SDVYKKMIEMEN--LAETRLKAISLL 619
+V EL + ++L V + ++++ +D +++ +N + + + L
Sbjct: 841 KEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLS 900
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ ++ ++ Q+ + + E+K D+S S + EI + LE ID + +E
Sbjct: 901 KQKEIEMAQKKMNSENSHSHEEEK--DLSHKNS-MLQEEIAMLRLE--IDTIKNQNQEKE 955
Query: 680 L-VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY-------IQENMDLTDKLE--KMSA 729
E+LK+ KE+ K ++ ++E + + Y EN L KLE K S
Sbjct: 956 KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSK 1015
Query: 730 EKI--------SELLAKINHEEQS---KIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
E++ S L A I+ +QS K + + E + + ++S K
Sbjct: 1016 ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN 1075
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEK-------QKAYSEYTIQEDELVNR----- 826
L + + E + SLE + L+EK QK S+ Q E+ +
Sbjct: 1076 EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1135
Query: 827 --LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ + VE++L +++ EN L+++ + N + ++ ++Q ++A+V+K
Sbjct: 1136 VKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1195
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
+E +S + + ++L S + E Q +K E E + + ++ ++ +
Sbjct: 1196 AE--SEKQSLLLEERNKELISECNHLK-ERQYQYENEKAEREVVVRQLQQELADTLKKQS 1252
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
+ E Y LE + Q+ K + + ++E + E + + +K Q D+
Sbjct: 1253 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-RCAEKMQ----DHK 1307
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE-NMEEE 1063
++ + KL +K++ ++I L + + NA +S + KL + LE N+++E
Sbjct: 1308 QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE--KEQLKKLMELKQSLECNLDQE 1365
Query: 1064 MQR---VSKQLLDSKQHNEELQILVREQDDQI----KELKETKLTFEMNIPKTEGMI--I 1114
M++ + +++ K + + + E ++ +LK ++ ++ I K + I +
Sbjct: 1366 MKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDL 1425
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQE-RSVLQEQSAKLNTELQECY 1172
++ +E ++D +K VQ++ E +Q+ + L+++ L + ++
Sbjct: 1426 TAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNM 1485
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVD 1229
++ Q++ E+ + QE +LK L+ +NL +S+ S ++
Sbjct: 1486 VELGQVKQYKQEI--EERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQME 1543
Query: 1230 QRGFEI-AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT 1288
R ++ +EL K +Q DF KTE E QL E K + L S + T E ++ T
Sbjct: 1544 LRIKDLESELSKIKTSQE--DFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNT 1601
Query: 1289 MEQVTSLQNK 1298
V Q++
Sbjct: 1602 KLLVEKQQSR 1611
Score = 89.8 bits (213), Expect = 7e-17
Identities = 159/847 (18%), Positives = 364/847 (42%), Gaps = 63/847 (7%)
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
EID K SN K K+K +++D+ ++ S+ E EL H S K L E
Sbjct: 671 EIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSS-ETASEDCELPHSSYKNFMLLIE 729
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
QL + DS +++ + + E L E + LL + + ++++LQ++
Sbjct: 730 ----QLGMECKDSVSLLK--IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQREL 783
Query: 638 DEVEDKLADISQLQSD---QVCSEIKSVHLEEQ----IDAL-SASKKELALVIENLKLD- 688
E ++ + + + + ++CS S++ EE+ D L +++L E + +
Sbjct: 784 SETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV 843
Query: 689 --KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
K+QL +++ LE + + + L +QE D +L + ++ + NH +Q
Sbjct: 844 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQK 903
Query: 746 KIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
+I+ Q ++++ +++ + S + I L I ++++ E+K +
Sbjct: 904 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 963
Query: 805 YLQEKQKAYSEYTIQEDELV--------NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
++EK + + Q +E + RL+VL + ++ +L E+E + ++
Sbjct: 964 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL---ENEKQSKERLEA 1020
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + L ++ D Q + E A E ++ Q ++ SNLK
Sbjct: 1021 EVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ 1080
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + ++ LEIEF+ A+R+K + E+ +K++ +Q + Q++E + +N +
Sbjct: 1081 QLFKTESKLNSLEIEFH-HTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQV 1136
Query: 977 NVEE-LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
V + + K E +++ + + Q+++ +Q + NK + K++ +I + + +A
Sbjct: 1137 KVNKYIGKQ--ESVEERLSQLQSENMLLRQQLDDAHNKAD----NKEKTVINIQDQF-HA 1189
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
V + S+ +S L + K + E + ++ + E +++VR+ ++ +
Sbjct: 1190 IVQKLQAESEKQSLLLEERNK--ELISECNHLKERQYQYENEKAEREVVVRQLQQELADT 1247
Query: 1096 KETKLTFEMNIPKTEGMIIS--STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
+ + E ++ T I+ + + + V+ E+
Sbjct: 1248 LKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTE-AVRCAEKMQDH 1306
Query: 1154 RSVLQEQSAKLNTELQECYTKI--IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
+ L++ +AKL +++ KI +Q LN L+ + +EQ+ +L + L D
Sbjct: 1307 KQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE---KEQLKKLMELKQSLECNLD 1363
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ EL I+ + +L ++ D + ++ E+ +Q++ + K +
Sbjct: 1364 QEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKID 1423
Query: 1270 QLLDSVQSSTQE----ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
L ++++ + +T + E++ S++ + E+ +N ++ +VIN LRS
Sbjct: 1424 DLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN----LRS 1479
Query: 1326 EIEDEKV 1332
IE V
Sbjct: 1480 HIERNMV 1486
Score = 81.8 bits (193), Expect = 2e-14
Identities = 184/904 (20%), Positives = 362/904 (40%), Gaps = 101/904 (11%)
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISE--LLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
NK++N IQ +MD D L + S+E SE L +++ + Q G++ K L I+
Sbjct: 688 NKVKNQIQ-SMDDVDDLTQ-SSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQ 745
Query: 766 NIE---SELSKYKSRICRL-EESIAVMEDRRYSLERKADQ---LGSYLQ------EKQKA 812
+ L + K C L I MED+ L+R+ + + S L+ E++
Sbjct: 746 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 805
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+++ ++E R A + ++++ E+ + E KE++ K Q+ L Q L++ L +
Sbjct: 806 SLRFSLNQEEEKRRNADTL-YEKIREQLRRKEEQYRKEVEVKQQLELSL-QTLEMELRTV 863
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEF 932
+ + N +V++ N Q QL E N + + T + K+KEIE + +
Sbjct: 864 KSNLNQVVQERNDA----------QRQL-SREQNARMLQDGILTNHLSKQKEIEMAQKKM 912
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N++ + ++K L+ K E + L ++ + I+N N E+ +L+++ +
Sbjct: 913 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCFEDLKIVKEK 968
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+ Q E I++ N L E LN K+ N + S + ++ ES ++
Sbjct: 969 NEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSR 1028
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + ++ + L ++ +E L + + + LK+ + KTE
Sbjct: 1029 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK 1088
Query: 1113 IISSTIE------PMSDDANNVDXXXXXXXXXXXXLKVQEE---------------EEFI 1151
+ S IE + + ++ +K E+ +E +
Sbjct: 1089 LNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESV 1148
Query: 1152 QER-SVLQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+ER S LQ ++ L +L + + K E +N + H +V + Q K L L
Sbjct: 1149 EERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL-LLEE 1207
Query: 1209 ENDNLLSTVAEL----------RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH--- 1255
N L+S L ++ V Q E+A+ K+ + EA + T
Sbjct: 1208 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRI 1266
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L + + K Q+ + +Q + T + E++ + KL+ L+ +K D
Sbjct: 1267 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD 1326
Query: 1316 VINQIE--ILRSEI-EDEK------VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS 1366
I +++ +L + + EDEK + +L E +K + + +
Sbjct: 1327 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1386
Query: 1367 ILNINE-ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+NE EN + ++N + K+ +LT +LE S+ +
Sbjct: 1387 RKKLNEYENGEF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSK--------CL 1437
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKES-ELAILRLKMHENANHYE---TMQKESE 1481
L +N + + +K+ E L K+ E ++ L+ H N E Q + E
Sbjct: 1438 HLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE 1497
Query: 1482 IERVKLIEELNVKITE-SVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
IE + +E+ K+ E ++ L Q A + LE+ + N + E+ I L E+
Sbjct: 1498 IEE-RARQEIAEKLKEVNLFLQAQAAS-QENLEQ--FRENNFASMKSQMELRIKDLESEL 1553
Query: 1541 TNLQ 1544
+ ++
Sbjct: 1554 SKIK 1557
Score = 81.4 bits (192), Expect = 2e-14
Identities = 180/977 (18%), Positives = 393/977 (40%), Gaps = 82/977 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHS 272
D ++++ E+ + +EK ++ I+S D +++ + E A + L HS
Sbjct: 664 DDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMD----DVDDLTQSSETASEDCELPHS 719
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELL 331
+ L Q SCE E+++ L + ++ K+ +L
Sbjct: 720 SYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVL 779
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ + ++ +LE++ E + S R++ K++ +
Sbjct: 780 QRELSETKEIKSQLEHQKVEW--ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 837
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK------ 445
+ + K+ + + LEM ++++ +L V+ E++ +
Sbjct: 838 QYRKEVEVKQQLELSLQTLEMELRTVKSNL---NQVVQERNDAQRQLSREQNARMLQDGI 894
Query: 446 --DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQ---LKQELNDEIKDVNV- 498
+ L Q ++E Q H +D++ + + +QE+ L+ E+ D IK+ N
Sbjct: 895 LTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI-DTIKNQNQE 953
Query: 499 --KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQMQKTIDNFSKVSDSN 554
K E LK +E+ L I + + + S N +L + + + N SK+ +
Sbjct: 954 KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLN-SKLENEK 1012
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ RL E+ ++A ++ + + + D ++ + N + LK
Sbjct: 1013 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLK 1072
Query: 615 AIS-LLESQKFDLVQELHILQQKY----DEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
+ +L Q F +L+ L+ ++ D + +K + ++Q D ++ + +E++
Sbjct: 1073 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQ 1132
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK----LE 725
+ E+++ QL L +D NK N + +++ D+ ++
Sbjct: 1133 NEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQ 1192
Query: 726 KMSAE--KISELLAKINHEEQSKI----QTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
K+ AE K S LL + N E S+ + Q+ + + ER++ + ++ EL+ +
Sbjct: 1193 KLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQS 1252
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR---- 835
E S+ V R +LE + L L + + E + E V + DH +
Sbjct: 1253 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1312
Query: 836 -------VVEKQLLEIEHENKEL-------QKKNQI--LLEENQNLQISLSDMQQHYNAL 879
V+KQ+ +IE K L +K Q+ L+E Q+L+ +L D + N
Sbjct: 1313 DNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNL-DQEMKKNVE 1371
Query: 880 VEK-----ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
+E+ N + + +Y+ +LK E I + K +I+DL E T
Sbjct: 1372 LEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELET 1431
Query: 935 QIESAIR-DKK--VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE---ELNKMNLEL 988
+ D K +L E+ +++ V + +LQ+ K +E +N+ E N + L
Sbjct: 1432 AGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQ 1490
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM-VSDYE 1047
+ ++ Q+ + ++ + + E+N E + + + S M + + D E
Sbjct: 1491 VKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE 1550
Query: 1048 SKLAQFTTKLENMEE-EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI 1106
S+L++ T E+ + E+++ + L+ + + L + + ++++ E+ TKL E
Sbjct: 1551 SELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEV-NTKLLVEKQ- 1608
Query: 1107 PKTEGMIISSTIEPMSD 1123
++ + + T P+ +
Sbjct: 1609 -QSRSLFTTLTTRPVME 1624
Score = 61.3 bits (142), Expect = 3e-08
Identities = 156/801 (19%), Positives = 321/801 (40%), Gaps = 53/801 (6%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D++H ++ ++E+ +++L++++ ++ + ++K E +I++ KN+
Sbjct: 925 DLSHKNSMLQEE---IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 981
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T + K K+RL ++ES R+++ E
Sbjct: 982 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1041
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEK-GSLEIA-- 319
++ E+ L + E + K + E ++ + E K SLEI
Sbjct: 1042 SKRELELAFQRARDECSRLQDKMNFDVSN----LKDNNEILSQQLFKTESKLNSLEIEFH 1097
Query: 320 -NMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
L +K LE + + QT +++ E V+ K + R S +
Sbjct: 1098 HTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS 1157
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
+ + QL D +K N + ++Q L + + ++ E++
Sbjct: 1158 ENMLLR--QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISE 1215
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT-NTEDVNEIA-KVQEQLKQELNDEIKDV 496
+ + E + + T + ++E + +V + + L DE +D+
Sbjct: 1216 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDL 1275
Query: 497 NVK--DLIEKLKSAEEQITQLNDEIDAANKNMIKV-KSNHKLKLKQMQKTIDNFSKVSDS 553
K + +L+ A+++ T+ + + K+ K N KLK+ ++K +D ++
Sbjct: 1276 KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV-TVKKQMDKIEEL-QK 1333
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL 613
N L+E+ +K+ EL K +L+ +L D + + +E + +++ +NL +
Sbjct: 1334 NLLNANLSEDEKEQLKKLMEL---KQSLECNL-DQEMKKNVELE--REITGFKNLLKMTR 1387
Query: 614 KAISLLESQKFDLVQELHILQQKYDEVEDKLA-DISQLQSDQVCSEIKSVHLEEQIDALS 672
K ++ E+ +F +L Q + D +KL I L ++ + K +HL+ + L
Sbjct: 1388 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1447
Query: 673 ---ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
S K + E L+ +K++L + +L + E M +L Q ++ ++ + A
Sbjct: 1448 EELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1507
Query: 730 EKISE----LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS-----RICR 780
EK+ E L A+ +E + + + + +L I+++ESELSK K+
Sbjct: 1508 EKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTE 1567
Query: 781 LE-------ESIAVMEDRRYSL----ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
LE E + V + L ER A+ L EKQ++ S +T V
Sbjct: 1568 LEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPC 1627
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + + ++ I EN + N N +++ LS MQQ + + + A
Sbjct: 1628 VGNLNNSLDLNRKLIPRENLVISTSNP--RASNNSMENYLSKMQQELEKNITRELKEAAA 1685
Query: 890 ESESTKYQTQLRDL-ESNLKR 909
E ES + L ESNL +
Sbjct: 1686 ELESGSIASPLGSTDESNLNQ 1706
>AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein.
Length = 1710
Score = 89.8 bits (213), Expect = 7e-17
Identities = 206/1030 (20%), Positives = 429/1030 (41%), Gaps = 101/1030 (9%)
Query: 339 RQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDT 398
R+ NKE + + + K V S K+ R S + S + S L+ L D
Sbjct: 597 RKENKEYASSGPAL--QMKEVKSTEKE-----KRTSKESVNSPVFGKASLLTGGLLQVDD 649
Query: 399 DKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQ 458
D +++ + + ++ N+ K + S D +D +L H
Sbjct: 650 DSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDC-----ELPHSS 704
Query: 459 HMEGPSLIH-VGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
+ LI +G +D + K+Q+ L E E+K + + L K+K E+++ L
Sbjct: 705 YKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQ 764
Query: 517 DEIDAAN--KNMI---KVKSNHKL-----KLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
E+ K+ + KV+ +L L Q ++ N + + +E +R EE +
Sbjct: 765 RELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYR 824
Query: 567 LSQKVA---ELEEEKGNLQLHLVDYDSGRMIE--SDVYKKMIEMEN--LAETRLKAISLL 619
+V EL + ++L V + ++++ +D +++ +N + + + L
Sbjct: 825 KEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLS 884
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ ++ ++ Q+ + + E+K D+S S + EI + LE ID + +E
Sbjct: 885 KQKEIEMAQKKMNSENSHSHEEEK--DLSHKNS-MLQEEIAMLRLE--IDTIKNQNQEKE 939
Query: 680 L-VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY-------IQENMDLTDKLE--KMSA 729
E+LK+ KE+ K ++ ++E + + Y EN L KLE K S
Sbjct: 940 KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSK 999
Query: 730 EKI--------SELLAKINHEEQS---KIQTQFGIDAKIQERDLYIENIESELSKYKSRI 778
E++ S L A I+ +QS K + + E + + ++S K
Sbjct: 1000 ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN 1059
Query: 779 CRLEESIAVMEDRRYSLERKADQLGSYLQEK-------QKAYSEYTIQEDELVNR----- 826
L + + E + SLE + L+EK QK S+ Q E+ +
Sbjct: 1060 EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1119
Query: 827 --LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ + VE++L +++ EN L+++ + N + ++ ++Q ++A+V+K
Sbjct: 1120 VKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1179
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
+E +S + + ++L S + E Q +K E E + + ++ ++ +
Sbjct: 1180 AE--SEKQSLLLEERNKELISECNHLK-ERQYQYENEKAEREVVVRQLQQELADTLKKQS 1236
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
+ E Y LE + Q+ K + + ++E + E + + +K Q D+
Sbjct: 1237 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-RCAEKMQ----DHK 1291
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE-NMEEE 1063
++ + KL +K++ ++I L + + NA +S + KL + LE N+++E
Sbjct: 1292 QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE--KEQLKKLMELKQSLECNLDQE 1349
Query: 1064 MQR---VSKQLLDSKQHNEELQILVREQDDQI----KELKETKLTFEMNIPKTEGMI--I 1114
M++ + +++ K + + + E ++ +LK ++ ++ I K + I +
Sbjct: 1350 MKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDL 1409
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQE-RSVLQEQSAKLNTELQECY 1172
++ +E ++D +K VQ++ E +Q+ + L+++ L + ++
Sbjct: 1410 TAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNM 1469
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSK---LEQLNTENDNLLSTVAELRSSISSAVD 1229
++ Q++ E+ + QE +LK L+ +NL +S+ S ++
Sbjct: 1470 VELGQVKQYKQEI--EERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQME 1527
Query: 1230 QRGFEI-AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT 1288
R ++ +EL K +Q DF KTE E QL E K + L S + T E ++ T
Sbjct: 1528 LRIKDLESELSKIKTSQE--DFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNT 1585
Query: 1289 MEQVTSLQNK 1298
V Q++
Sbjct: 1586 KLLVEKQQSR 1595
Score = 89.8 bits (213), Expect = 7e-17
Identities = 159/847 (18%), Positives = 364/847 (42%), Gaps = 63/847 (7%)
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
EID K SN K K+K +++D+ ++ S+ E EL H S K L E
Sbjct: 655 EIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSS-ETASEDCELPHSSYKNFMLLIE 713
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
QL + DS +++ + + E L E + LL + + ++++LQ++
Sbjct: 714 ----QLGMECKDSVSLLK--IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQREL 767
Query: 638 DEVEDKLADISQLQSD---QVCSEIKSVHLEEQ----IDAL-SASKKELALVIENLKLD- 688
E ++ + + + + ++CS S++ EE+ D L +++L E + +
Sbjct: 768 SETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV 827
Query: 689 --KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
K+QL +++ LE + + + L +QE D +L + ++ + NH +Q
Sbjct: 828 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQK 887
Query: 746 KIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
+I+ Q ++++ +++ + S + I L I ++++ E+K +
Sbjct: 888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 947
Query: 805 YLQEKQKAYSEYTIQEDELV--------NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
++EK + + Q +E + RL+VL + ++ +L E+E + ++
Sbjct: 948 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL---ENEKQSKERLEA 1004
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + L ++ D Q + E A E ++ Q ++ SNLK
Sbjct: 1005 EVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ 1064
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + ++ LEIEF+ A+R+K + E+ +K++ +Q + Q++E + +N +
Sbjct: 1065 QLFKTESKLNSLEIEFH-HTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQV 1120
Query: 977 NVEE-LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
V + + K E +++ + + Q+++ +Q + NK + K++ +I + + +A
Sbjct: 1121 KVNKYIGKQ--ESVEERLSQLQSENMLLRQQLDDAHNKAD----NKEKTVINIQDQF-HA 1173
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
V + S+ +S L + K + E + ++ + E +++VR+ ++ +
Sbjct: 1174 IVQKLQAESEKQSLLLEERNK--ELISECNHLKERQYQYENEKAEREVVVRQLQQELADT 1231
Query: 1096 KETKLTFEMNIPKTEGMIIS--STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
+ + E ++ T I+ + + + V+ E+
Sbjct: 1232 LKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTE-AVRCAEKMQDH 1290
Query: 1154 RSVLQEQSAKLNTELQECYTKI--IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
+ L++ +AKL +++ KI +Q LN L+ + +EQ+ +L + L D
Sbjct: 1291 KQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE---KEQLKKLMELKQSLECNLD 1347
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ EL I+ + +L ++ D + ++ E+ +Q++ + K +
Sbjct: 1348 QEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKID 1407
Query: 1270 QLLDSVQSSTQE----ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
L ++++ + +T + E++ S++ + E+ +N ++ +VIN LRS
Sbjct: 1408 DLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN----LRS 1463
Query: 1326 EIEDEKV 1332
IE V
Sbjct: 1464 HIERNMV 1470
Score = 81.8 bits (193), Expect = 2e-14
Identities = 184/904 (20%), Positives = 362/904 (40%), Gaps = 101/904 (11%)
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISE--LLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
NK++N IQ +MD D L + S+E SE L +++ + Q G++ K L I+
Sbjct: 672 NKVKNQIQ-SMDDVDDLTQ-SSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQ 729
Query: 766 NIE---SELSKYKSRICRL-EESIAVMEDRRYSLERKADQ---LGSYLQ------EKQKA 812
+ L + K C L I MED+ L+R+ + + S L+ E++
Sbjct: 730 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 789
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+++ ++E R A + ++++ E+ + E KE++ K Q+ L Q L++ L +
Sbjct: 790 SLRFSLNQEEEKRRNADTL-YEKIREQLRRKEEQYRKEVEVKQQLELSL-QTLEMELRTV 847
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEF 932
+ + N +V++ N Q QL E N + + T + K+KEIE + +
Sbjct: 848 KSNLNQVVQERNDA----------QRQL-SREQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N++ + ++K L+ K E + L ++ + I+N N E+ +L+++ +
Sbjct: 897 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCFEDLKIVKEK 952
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+ Q E I++ N L E LN K+ N + S + ++ ES ++
Sbjct: 953 NEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSR 1012
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + ++ + L ++ +E L + + + LK+ + KTE
Sbjct: 1013 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK 1072
Query: 1113 IISSTIE------PMSDDANNVDXXXXXXXXXXXXLKVQEE---------------EEFI 1151
+ S IE + + ++ +K E+ +E +
Sbjct: 1073 LNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESV 1132
Query: 1152 QER-SVLQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+ER S LQ ++ L +L + + K E +N + H +V + Q K L L
Sbjct: 1133 EERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL-LLEE 1191
Query: 1209 ENDNLLSTVAEL----------RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH--- 1255
N L+S L ++ V Q E+A+ K+ + EA + T
Sbjct: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRI 1250
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L + + K Q+ + +Q + T + E++ + KL+ L+ +K D
Sbjct: 1251 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD 1310
Query: 1316 VINQIE--ILRSEI-EDEK------VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS 1366
I +++ +L + + EDEK + +L E +K + + +
Sbjct: 1311 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1370
Query: 1367 ILNINE-ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+NE EN + ++N + K+ +LT +LE S+ +
Sbjct: 1371 RKKLNEYENGEF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSK--------CL 1421
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKES-ELAILRLKMHENANHYE---TMQKESE 1481
L +N + + +K+ E L K+ E ++ L+ H N E Q + E
Sbjct: 1422 HLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE 1481
Query: 1482 IERVKLIEELNVKITE-SVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
IE + +E+ K+ E ++ L Q A + LE+ + N + E+ I L E+
Sbjct: 1482 IEE-RARQEIAEKLKEVNLFLQAQAAS-QENLEQ--FRENNFASMKSQMELRIKDLESEL 1537
Query: 1541 TNLQ 1544
+ ++
Sbjct: 1538 SKIK 1541
Score = 81.4 bits (192), Expect = 2e-14
Identities = 180/977 (18%), Positives = 393/977 (40%), Gaps = 82/977 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHS 272
D ++++ E+ + +EK ++ I+S D +++ + E A + L HS
Sbjct: 648 DDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMD----DVDDLTQSSETASEDCELPHS 703
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELL 331
+ L Q SCE E+++ L + ++ K+ +L
Sbjct: 704 SYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVL 763
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ + ++ +LE++ E + S R++ K++ +
Sbjct: 764 QRELSETKEIKSQLEHQKVEW--ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 821
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK------ 445
+ + K+ + + LEM ++++ +L V+ E++ +
Sbjct: 822 QYRKEVEVKQQLELSLQTLEMELRTVKSNL---NQVVQERNDAQRQLSREQNARMLQDGI 878
Query: 446 --DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQ---LKQELNDEIKDVNV- 498
+ L Q ++E Q H +D++ + + +QE+ L+ E+ D IK+ N
Sbjct: 879 LTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI-DTIKNQNQE 937
Query: 499 --KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQMQKTIDNFSKVSDSN 554
K E LK +E+ L I + + + S N +L + + + N SK+ +
Sbjct: 938 KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLN-SKLENEK 996
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ RL E+ ++A ++ + + + D ++ + N + LK
Sbjct: 997 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLK 1056
Query: 615 AIS-LLESQKFDLVQELHILQQKY----DEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
+ +L Q F +L+ L+ ++ D + +K + ++Q D ++ + +E++
Sbjct: 1057 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQ 1116
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK----LE 725
+ E+++ QL L +D NK N + +++ D+ ++
Sbjct: 1117 NEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQ 1176
Query: 726 KMSAE--KISELLAKINHEEQSKI----QTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
K+ AE K S LL + N E S+ + Q+ + + ER++ + ++ EL+ +
Sbjct: 1177 KLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQS 1236
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR---- 835
E S+ V R +LE + L L + + E + E V + DH +
Sbjct: 1237 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1296
Query: 836 -------VVEKQLLEIEHENKEL-------QKKNQI--LLEENQNLQISLSDMQQHYNAL 879
V+KQ+ +IE K L +K Q+ L+E Q+L+ +L D + N
Sbjct: 1297 DNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNL-DQEMKKNVE 1355
Query: 880 VEK-----ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
+E+ N + + +Y+ +LK E I + K +I+DL E T
Sbjct: 1356 LEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELET 1415
Query: 935 QIESAIR-DKK--VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE---ELNKMNLEL 988
+ D K +L E+ +++ V + +LQ+ K +E +N+ E N + L
Sbjct: 1416 AGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQ 1474
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM-VSDYE 1047
+ ++ Q+ + ++ + + E+N E + + + S M + + D E
Sbjct: 1475 VKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE 1534
Query: 1048 SKLAQFTTKLENMEE-EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI 1106
S+L++ T E+ + E+++ + L+ + + L + + ++++ E+ TKL E
Sbjct: 1535 SELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEV-NTKLLVEKQ- 1592
Query: 1107 PKTEGMIISSTIEPMSD 1123
++ + + T P+ +
Sbjct: 1593 -QSRSLFTTLTTRPVME 1608
Score = 61.3 bits (142), Expect = 3e-08
Identities = 156/801 (19%), Positives = 321/801 (40%), Gaps = 53/801 (6%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D++H ++ ++E+ +++L++++ ++ + ++K E +I++ KN+
Sbjct: 909 DLSHKNSMLQEE---IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 965
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T + K K+RL ++ES R+++ E
Sbjct: 966 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1025
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEK-GSLEIA-- 319
++ E+ L + E + K + E ++ + E K SLEI
Sbjct: 1026 SKRELELAFQRARDECSRLQDKMNFDVSN----LKDNNEILSQQLFKTESKLNSLEIEFH 1081
Query: 320 -NMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
L +K LE + + QT +++ E V+ K + R S +
Sbjct: 1082 HTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS 1141
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
+ + QL D +K N + ++Q L + + ++ E++
Sbjct: 1142 ENMLLR--QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISE 1199
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT-NTEDVNEIA-KVQEQLKQELNDEIKDV 496
+ + E + + T + ++E + +V + + L DE +D+
Sbjct: 1200 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDL 1259
Query: 497 NVK--DLIEKLKSAEEQITQLNDEIDAANKNMIKV-KSNHKLKLKQMQKTIDNFSKVSDS 553
K + +L+ A+++ T+ + + K+ K N KLK+ ++K +D ++
Sbjct: 1260 KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV-TVKKQMDKIEEL-QK 1317
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL 613
N L+E+ +K+ EL K +L+ +L D + + +E + +++ +NL +
Sbjct: 1318 NLLNANLSEDEKEQLKKLMEL---KQSLECNL-DQEMKKNVELE--REITGFKNLLKMTR 1371
Query: 614 KAISLLESQKFDLVQELHILQQKYDEVEDKLA-DISQLQSDQVCSEIKSVHLEEQIDALS 672
K ++ E+ +F +L Q + D +KL I L ++ + K +HL+ + L
Sbjct: 1372 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1431
Query: 673 ---ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
S K + E L+ +K++L + +L + E M +L Q ++ ++ + A
Sbjct: 1432 EELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1491
Query: 730 EKISE----LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS-----RICR 780
EK+ E L A+ +E + + + + +L I+++ESELSK K+
Sbjct: 1492 EKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTE 1551
Query: 781 LE-------ESIAVMEDRRYSL----ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
LE E + V + L ER A+ L EKQ++ S +T V
Sbjct: 1552 LEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPC 1611
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + + ++ I EN + N N +++ LS MQQ + + + A
Sbjct: 1612 VGNLNNSLDLNRKLIPRENLVISTSNP--RASNNSMENYLSKMQQELEKNITRELKEAAA 1669
Query: 890 ESESTKYQTQLRDL-ESNLKR 909
E ES + L ESNL +
Sbjct: 1670 ELESGSIASPLGSTDESNLNQ 1690
>AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein.
Length = 1715
Score = 89.8 bits (213), Expect = 7e-17
Identities = 159/847 (18%), Positives = 364/847 (42%), Gaps = 63/847 (7%)
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
EID K SN K K+K +++D+ ++ S+ E EL H S K L E
Sbjct: 660 EIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSS-ETASEDCELPHSSYKNFMLLIE 718
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
QL + DS +++ + + E L E + LL + + ++++LQ++
Sbjct: 719 ----QLGMECKDSVSLLK--IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQREL 772
Query: 638 DEVEDKLADISQLQSD---QVCSEIKSVHLEEQ----IDAL-SASKKELALVIENLKLD- 688
E ++ + + + + ++CS S++ EE+ D L +++L E + +
Sbjct: 773 SETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV 832
Query: 689 --KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
K+QL +++ LE + + + L +QE D +L + ++ + NH +Q
Sbjct: 833 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQK 892
Query: 746 KIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
+I+ Q ++++ +++ + S + I L I ++++ E+K +
Sbjct: 893 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 952
Query: 805 YLQEKQKAYSEYTIQEDELV--------NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
++EK + + Q +E + RL+VL + ++ +L E+E + ++
Sbjct: 953 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL---ENEKQSKERLEA 1009
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + L ++ D Q + E A E ++ Q ++ SNLK
Sbjct: 1010 EVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ 1069
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + ++ LEIEF+ A+R+K + E+ +K++ +Q + Q++E + +N +
Sbjct: 1070 QLFKTESKLNSLEIEFH-HTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQV 1125
Query: 977 NVEE-LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
V + + K E +++ + + Q+++ +Q + NK + K++ +I + + +A
Sbjct: 1126 KVNKYIGKQ--ESVEERLSQLQSENMLLRQQLDDAHNKAD----NKEKTVINIQDQF-HA 1178
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
V + S+ +S L + K + E + ++ + E +++VR+ ++ +
Sbjct: 1179 IVQKLQAESEKQSLLLEERNK--ELISECNHLKERQYQYENEKAEREVVVRQLQQELADT 1236
Query: 1096 KETKLTFEMNIPKTEGMIIS--STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
+ + E ++ T I+ + + + V+ E+
Sbjct: 1237 LKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTE-AVRCAEKMQDH 1295
Query: 1154 RSVLQEQSAKLNTELQECYTKI--IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
+ L++ +AKL +++ KI +Q LN L+ + +EQ+ +L + L D
Sbjct: 1296 KQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE---KEQLKKLMELKQSLECNLD 1352
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ EL I+ + +L ++ D + ++ E+ +Q++ + K +
Sbjct: 1353 QEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKID 1412
Query: 1270 QLLDSVQSSTQE----ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
L ++++ + +T + E++ S++ + E+ +N ++ +VIN LRS
Sbjct: 1413 DLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN----LRS 1468
Query: 1326 EIEDEKV 1332
IE V
Sbjct: 1469 HIERNMV 1475
Score = 89.4 bits (212), Expect = 9e-17
Identities = 186/923 (20%), Positives = 392/923 (42%), Gaps = 89/923 (9%)
Query: 446 DTLIAQLQLEHQQHMEGPSLIH-VGTNTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIE 503
+T +L H + LI +G +D + K+Q+ L E E+K + + L
Sbjct: 697 ETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTV 756
Query: 504 KLKSAEEQITQLNDEIDAAN--KNMI---KVKSNHKL-----KLKQMQKTIDNFSKVSDS 553
K+K E+++ L E+ K+ + KV+ +L L Q ++ N + +
Sbjct: 757 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEK 816
Query: 554 NKEIVRLTEELHHLSQKVA---ELEEEKGNLQLHLVDYDSGRMIE--SDVYKKMIEMEN- 607
+E +R EE + +V EL + ++L V + ++++ +D +++ +N
Sbjct: 817 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNA 876
Query: 608 -LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ + + L + ++ ++ Q+ + + E+K D+S S + EI + LE
Sbjct: 877 RMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEK--DLSHKNS-MLQEEIAMLRLE- 932
Query: 667 QIDALSASKKELAL-VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY-------IQENM 718
ID + +E E+LK+ KE+ K ++ ++E + + Y EN
Sbjct: 933 -IDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENA 991
Query: 719 DLTDKLE--KMSAEKI--------SELLAKINHEEQS---KIQTQFGIDAKIQERDLYIE 765
L KLE K S E++ S L A I+ +QS K + + E +
Sbjct: 992 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1051
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK-------QKAYSEYTI 818
+ ++S K L + + E + SLE + L+EK QK S+
Sbjct: 1052 KMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQC 1111
Query: 819 QEDELVNR-------LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSD 871
Q E+ + + + VE++L +++ EN L+++ + N + ++ +
Sbjct: 1112 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1171
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
+Q ++A+V+K +E +S + + ++L S + E Q +K E E + +
Sbjct: 1172 IQDQFHAIVQKLQAE--SEKQSLLLEERNKELISECNHLK-ERQYQYENEKAEREVVVRQ 1228
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
++ ++ + + E Y LE + Q+ K + + ++E + E + +
Sbjct: 1229 LQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-R 1287
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
+K Q D+ ++ + KL +K++ ++I L + + NA +S + KL
Sbjct: 1288 CAEKMQ----DHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE--KEQLKKLM 1341
Query: 1052 QFTTKLE-NMEEEMQR---VSKQLLDSKQHNEELQILVREQDDQI----KELKETKLTFE 1103
+ LE N+++EM++ + +++ K + + + E ++ +LK ++ +
Sbjct: 1342 ELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD 1401
Query: 1104 MNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQE-RSVLQE 1159
+ I K + I +++ +E ++D +K VQ++ E +Q+ + L++
Sbjct: 1402 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQ 1461
Query: 1160 QSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK---LEQLNTENDNLLST 1216
+ L + ++ ++ Q++ E+ + QE +LK L+ +NL
Sbjct: 1462 EVINLRSHIERNMVELGQVKQYKQEI--EERARQEIAEKLKEVNLFLQAQAASQENLEQF 1519
Query: 1217 VAELRSSISSAVDQRGFEI-AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+S+ S ++ R ++ +EL K +Q DF KTE E QL E K + L S
Sbjct: 1520 RENNFASMKSQMELRIKDLESELSKIKTSQE--DFNKTELEKYKQLYLEELKVRKSLSSK 1577
Query: 1276 QSSTQEETNKIVTMEQVTSLQNK 1298
+ T E ++ T V Q++
Sbjct: 1578 LTKTNERLAEVNTKLLVEKQQSR 1600
Score = 81.8 bits (193), Expect = 2e-14
Identities = 184/904 (20%), Positives = 362/904 (40%), Gaps = 101/904 (11%)
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISE--LLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
NK++N IQ +MD D L + S+E SE L +++ + Q G++ K L I+
Sbjct: 677 NKVKNQIQ-SMDDVDDLTQ-SSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQ 734
Query: 766 NIE---SELSKYKSRICRL-EESIAVMEDRRYSLERKADQ---LGSYLQ------EKQKA 812
+ L + K C L I MED+ L+R+ + + S L+ E++
Sbjct: 735 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 794
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+++ ++E R A + ++++ E+ + E KE++ K Q+ L Q L++ L +
Sbjct: 795 SLRFSLNQEEEKRRNADTL-YEKIREQLRRKEEQYRKEVEVKQQLELSL-QTLEMELRTV 852
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEF 932
+ + N +V++ N Q QL E N + + T + K+KEIE + +
Sbjct: 853 KSNLNQVVQERNDA----------QRQL-SREQNARMLQDGILTNHLSKQKEIEMAQKKM 901
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N++ + ++K L+ K E + L ++ + I+N N E+ +L+++ +
Sbjct: 902 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCFEDLKIVKEK 957
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+ Q E I++ N L E LN K+ N + S + ++ ES ++
Sbjct: 958 NEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSR 1017
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + ++ + L ++ +E L + + + LK+ + KTE
Sbjct: 1018 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK 1077
Query: 1113 IISSTIE------PMSDDANNVDXXXXXXXXXXXXLKVQEE---------------EEFI 1151
+ S IE + + ++ +K E+ +E +
Sbjct: 1078 LNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESV 1137
Query: 1152 QER-SVLQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+ER S LQ ++ L +L + + K E +N + H +V + Q K L L
Sbjct: 1138 EERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL-LLEE 1196
Query: 1209 ENDNLLSTVAEL----------RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH--- 1255
N L+S L ++ V Q E+A+ K+ + EA + T
Sbjct: 1197 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRI 1255
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L + + K Q+ + +Q + T + E++ + KL+ L+ +K D
Sbjct: 1256 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD 1315
Query: 1316 VINQIE--ILRSEI-EDEK------VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS 1366
I +++ +L + + EDEK + +L E +K + + +
Sbjct: 1316 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1375
Query: 1367 ILNINE-ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+NE EN + ++N + K+ +LT +LE S+ +
Sbjct: 1376 RKKLNEYENGEF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSK--------CL 1426
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKES-ELAILRLKMHENANHYE---TMQKESE 1481
L +N + + +K+ E L K+ E ++ L+ H N E Q + E
Sbjct: 1427 HLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE 1486
Query: 1482 IERVKLIEELNVKITE-SVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
IE + +E+ K+ E ++ L Q A + LE+ + N + E+ I L E+
Sbjct: 1487 IEE-RARQEIAEKLKEVNLFLQAQAAS-QENLEQ--FRENNFASMKSQMELRIKDLESEL 1542
Query: 1541 TNLQ 1544
+ ++
Sbjct: 1543 SKIK 1546
Score = 81.4 bits (192), Expect = 2e-14
Identities = 180/977 (18%), Positives = 393/977 (40%), Gaps = 82/977 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHS 272
D ++++ E+ + +EK ++ I+S D +++ + E A + L HS
Sbjct: 653 DDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMD----DVDDLTQSSETASEDCELPHS 708
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELL 331
+ L Q SCE E+++ L + ++ K+ +L
Sbjct: 709 SYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVL 768
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ + ++ +LE++ E + S R++ K++ +
Sbjct: 769 QRELSETKEIKSQLEHQKVEW--ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 826
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK------ 445
+ + K+ + + LEM ++++ +L V+ E++ +
Sbjct: 827 QYRKEVEVKQQLELSLQTLEMELRTVKSNL---NQVVQERNDAQRQLSREQNARMLQDGI 883
Query: 446 --DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQ---LKQELNDEIKDVNV- 498
+ L Q ++E Q H +D++ + + +QE+ L+ E+ D IK+ N
Sbjct: 884 LTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI-DTIKNQNQE 942
Query: 499 --KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQMQKTIDNFSKVSDSN 554
K E LK +E+ L I + + + S N +L + + + N SK+ +
Sbjct: 943 KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLN-SKLENEK 1001
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ RL E+ ++A ++ + + + D ++ + N + LK
Sbjct: 1002 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLK 1061
Query: 615 AIS-LLESQKFDLVQELHILQQKY----DEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
+ +L Q F +L+ L+ ++ D + +K + ++Q D ++ + +E++
Sbjct: 1062 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQ 1121
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK----LE 725
+ E+++ QL L +D NK N + +++ D+ ++
Sbjct: 1122 NEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQ 1181
Query: 726 KMSAE--KISELLAKINHEEQSKI----QTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
K+ AE K S LL + N E S+ + Q+ + + ER++ + ++ EL+ +
Sbjct: 1182 KLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQS 1241
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR---- 835
E S+ V R +LE + L L + + E + E V + DH +
Sbjct: 1242 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1301
Query: 836 -------VVEKQLLEIEHENKEL-------QKKNQI--LLEENQNLQISLSDMQQHYNAL 879
V+KQ+ +IE K L +K Q+ L+E Q+L+ +L D + N
Sbjct: 1302 DNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNL-DQEMKKNVE 1360
Query: 880 VEK-----ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
+E+ N + + +Y+ +LK E I + K +I+DL E T
Sbjct: 1361 LEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELET 1420
Query: 935 QIESAIR-DKK--VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE---ELNKMNLEL 988
+ D K +L E+ +++ V + +LQ+ K +E +N+ E N + L
Sbjct: 1421 AGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQ 1479
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM-VSDYE 1047
+ ++ Q+ + ++ + + E+N E + + + S M + + D E
Sbjct: 1480 VKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE 1539
Query: 1048 SKLAQFTTKLENMEE-EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI 1106
S+L++ T E+ + E+++ + L+ + + L + + ++++ E+ TKL E
Sbjct: 1540 SELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEV-NTKLLVEKQ- 1597
Query: 1107 PKTEGMIISSTIEPMSD 1123
++ + + T P+ +
Sbjct: 1598 -QSRSLFTTLTTRPVME 1613
Score = 61.3 bits (142), Expect = 3e-08
Identities = 156/801 (19%), Positives = 321/801 (40%), Gaps = 53/801 (6%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D++H ++ ++E+ +++L++++ ++ + ++K E +I++ KN+
Sbjct: 914 DLSHKNSMLQEE---IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 970
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T + K K+RL ++ES R+++ E
Sbjct: 971 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1030
Query: 263 ARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEK-GSLEIA-- 319
++ E+ L + E + K + E ++ + E K SLEI
Sbjct: 1031 SKRELELAFQRARDECSRLQDKMNFDVSN----LKDNNEILSQQLFKTESKLNSLEIEFH 1086
Query: 320 -NMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
L +K LE + + QT +++ E V+ K + R S +
Sbjct: 1087 HTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS 1146
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
+ + QL D +K N + ++Q L + + ++ E++
Sbjct: 1147 ENMLLR--QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISE 1204
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT-NTEDVNEIA-KVQEQLKQELNDEIKDV 496
+ + E + + T + ++E + +V + + L DE +D+
Sbjct: 1205 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDL 1264
Query: 497 NVK--DLIEKLKSAEEQITQLNDEIDAANKNMIKV-KSNHKLKLKQMQKTIDNFSKVSDS 553
K + +L+ A+++ T+ + + K+ K N KLK+ ++K +D ++
Sbjct: 1265 KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV-TVKKQMDKIEEL-QK 1322
Query: 554 NKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL 613
N L+E+ +K+ EL K +L+ +L D + + +E + +++ +NL +
Sbjct: 1323 NLLNANLSEDEKEQLKKLMEL---KQSLECNL-DQEMKKNVELE--REITGFKNLLKMTR 1376
Query: 614 KAISLLESQKFDLVQELHILQQKYDEVEDKLA-DISQLQSDQVCSEIKSVHLEEQIDALS 672
K ++ E+ +F +L Q + D +KL I L ++ + K +HL+ + L
Sbjct: 1377 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1436
Query: 673 ---ASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
S K + E L+ +K++L + +L + E M +L Q ++ ++ + A
Sbjct: 1437 EELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1496
Query: 730 EKISE----LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS-----RICR 780
EK+ E L A+ +E + + + + +L I+++ESELSK K+
Sbjct: 1497 EKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTE 1556
Query: 781 LE-------ESIAVMEDRRYSL----ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV 829
LE E + V + L ER A+ L EKQ++ S +T V
Sbjct: 1557 LEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPC 1616
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + + ++ I EN + N N +++ LS MQQ + + + A
Sbjct: 1617 VGNLNNSLDLNRKLIPRENLVISTSNP--RASNNSMENYLSKMQQELEKNITRELKEAAA 1674
Query: 890 ESESTKYQTQLRDL-ESNLKR 909
E ES + L ESNL +
Sbjct: 1675 ELESGSIASPLGSTDESNLNQ 1695
>AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 89.4 bits (212), Expect = 9e-17
Identities = 223/1106 (20%), Positives = 463/1106 (41%), Gaps = 102/1106 (9%)
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEE----QITQLNDEIDAA---NKNMIKVKSNHKLK-- 536
+ L D ++D +DL+E+L++AEE + L++++D NK I + KL
Sbjct: 523 ENSLEDLMED---EDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDL 579
Query: 537 LKQMQKTIDNFSKVSDSNKEIVR--LTEEL-HHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
++ ++K + N K + + +R +T+E + +Q+ A+ +E + L + R+
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 594 -IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED--KLADISQL 650
I D+ K E A+ + A + + + V I+ D V D K A+I+ L
Sbjct: 640 AIFKDLVGKCDTREEAAKD-ICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAEIAHL 698
Query: 651 --------QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
Q C E+K ++ + L+ +K EL E LK + + I++LE
Sbjct: 699 YIASLPDPQEATACLELKFNQIKAE---LAKTKGELIKTKEELKKRENESDSLIQELETS 755
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KIQTQFGIDAKIQERD 761
+ I+ + Q I+E +++ D+ E + I+E +H E + K + + I
Sbjct: 756 NKKIITQNQR-IKELINIIDQKE----DTINEFQNLKSHMENTFKCNDKADTSSLIINNK 810
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTIQ 819
L KS+IC + + E ++ K + S + E QK E
Sbjct: 811 LICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPN 870
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
E+ + + VL +++ + LL IE+E K + EE L + QQ + L
Sbjct: 871 IAEIED-IRVLQENNEGLRAFLLTIENELKNEK-------EEKAELNKQIVHFQQELS-L 921
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IES 938
EK N T E + + + E ++++ ++ Q + K EIE T+ I +
Sbjct: 922 SEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSN----EIETATRSITN 977
Query: 939 AIRDKKVLNEKYE--KNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKM-NLELIDK 991
+ K+++ K + + ++ V+Q+ L++ N E N+ +L+ + N L+ K
Sbjct: 978 NVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSK 1037
Query: 992 HVQKQQTQSPDYTEQYINEINKL----NALLK---QKDEEIIALNQKINNAQVSYMSMVS 1044
V++ + Q P+ + + I + ++K +K +I L Q+I Q
Sbjct: 1038 QVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY-K 1096
Query: 1045 DYESKLAQFTTK-LENMEEEMQRVSKQLLDSKQH-NEELQILVR---EQDDQIKELKETK 1099
D ++L + K +++ +E + + +QL + Q N L + ++ E + EL +
Sbjct: 1097 DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV 1156
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER----S 1155
++ I + E ++ + +E D ++E +E +Q+
Sbjct: 1157 TCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK 1216
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
L + KL E+ + + ++ L + N+++ +LK +L + NL
Sbjct: 1217 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK- 1275
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHEL-RVQLSAFESKYEQL-- 1271
A+L+ D + ++ + KQ Q+E + E +L R++++ E K Q
Sbjct: 1276 --ADLQRKEEDYADLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQ 1332
Query: 1272 -LDSVQSSTQ---EETNKIVTMEQVTSLQNKLQD---KEEHLRNLQEKYADVINQIEILR 1324
LD Q + Q E+ N E + + +D KE+ + +++ + Q ++ +
Sbjct: 1333 ELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ-EQTQVEQ 1391
Query: 1325 SEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXX 1384
++ + K+ DL T+N + ++ ++ + L+
Sbjct: 1392 DQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQ 1449
Query: 1385 XXXXXXXXXRVNDAEAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
R E K++ +T E +++ E+ + + Q+N E E + QL
Sbjct: 1450 ESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN-EMEILTAQL 1508
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
E + ++ E++ +A L +++ A +QK++EIE++K I KI E+ +
Sbjct: 1509 TEKDSDLQKWREERDQLVAALEIQL--KALISSNVQKDNEIEQLKRIISETSKI-ETQIM 1565
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALE 1527
+ + ++ A + + +T + T+ E
Sbjct: 1566 DIKPKRISSA-DPDKLQTEPLSTSFE 1590
Score = 87.0 bits (206), Expect = 5e-16
Identities = 205/1041 (19%), Positives = 431/1041 (41%), Gaps = 105/1041 (10%)
Query: 562 EELHHLSQKVAELE--EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
E+L V ELE EE N++ L+D D + +E + K I E + K + L+
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEEN--KAFISHEE----KRKLLDLI 580
Query: 620 ESQKFDLVQEL-HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
E K L+ E L ++ E+ + +Q + + ++ K L+E+ + L + +
Sbjct: 581 EDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQRE-ADFKETLLQER-EILEENAERR 638
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ ++L + KD+ K + + NY+ D+ D L+ A+ + A+
Sbjct: 639 LAIFKDLVGKCDTREEAAKDICATKVET-EETHNYVGFE-DIIDSLQDNVADIKKQ--AE 694
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
I H + + A ++ L I++EL+K K + + +E L+++
Sbjct: 695 IAHLYIASLPDPQEATACLE---LKFNQIKAELAKTKGELIKTKEE----------LKKR 741
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
++ S +QE + + ++ I +++ + L ++D +K+ E +N + +N
Sbjct: 742 ENESDSLIQELETS-NKKIITQNQRIKELINIID-----QKEDTINEFQNLKSHMENTFK 795
Query: 859 LEENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + + + + N VE K +++ + + +L+ E K+ + +
Sbjct: 796 CNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSS 855
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
I + +K+ E++ + I D +VL E E ++ +E +L+ K LN
Sbjct: 856 AITEDQKKSEEVRPNI-----AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK 910
Query: 977 NVEELNKMNLELIDKH---VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
+ + L L +K + K+ Q + I E++ + ++++E+I+ L+ +I
Sbjct: 911 QIVHFQQ-ELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 969
Query: 1034 NAQVSYMSMVSDYE---SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
A S + VS + +K+ + T L+++ + L D +EE + + D
Sbjct: 970 TATRSITNNVSQIKLMHTKIDELRT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 1028
Query: 1091 QIKELKETKLTFEMNI--PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ--- 1145
+ +K E I P E SS IE + ++ + L+ Q
Sbjct: 1029 LGNDYLVSKQVKEYRIQEPNRENSFHSS-IEAIWEECKEIVKASSKKSHQIEELEQQIEK 1087
Query: 1146 ---EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
E + + E + L+E+ K +L + +IQ L EL +V QI +
Sbjct: 1088 LQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQ--QLKEELQEKNVTLDVQIQHVVEG 1145
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQREADFQKTEHELRVQ 1260
L+ + A+++ + + ++ + E + K Q + ++E+ K E L+
Sbjct: 1146 KRALSELTQGVTCYKAKIKE-LETILETQKVECSHSAKLEQDILEKESIILKLERNLK-- 1202
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
F+ E L DSV+++ ++ E++T L N LQD +HL L+E+ + Q
Sbjct: 1203 --EFQ---EHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ- 1255
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
E EK+ DL+ + + Y ++E+ + + ++ Q++K
Sbjct: 1256 -------ETEKL--KEELSASSARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQKE 1305
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
++N+ E K + + +L++K I Q Q N+ + V +
Sbjct: 1306 VSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE-------QLNN--QKVEEA 1356
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS 1500
+ +YE+ +DL KE + +R+ + E +T ++ ++ KL EE+ TE
Sbjct: 1357 IQQYERACKDLNV-KEKIIEDMRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATELEK 1411
Query: 1501 LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK-IQKHVS 1559
++ +L + K +E T + ++ L DE+ + A K +++ +
Sbjct: 1412 WKEKCNDLETKNNQRSNKEHENNTDVLG---KLTNLQDELQESEQKYNADRKKWLEEKMM 1468
Query: 1560 FASDTKQGRDEQLDNTMNKEL 1580
+ K+ +N NKE+
Sbjct: 1469 LITQAKEA-----ENIRNKEM 1484
Score = 82.6 bits (195), Expect = 1e-14
Identities = 161/753 (21%), Positives = 334/753 (44%), Gaps = 87/753 (11%)
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL-- 535
++K +Q++ + I +++V+ K + EE+I +L++EI+ A +++ S KL
Sbjct: 929 LSKEVQQIQSNYDIAIAELHVQK--SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 986
Query: 536 -KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K+ ++ +T+D+ S++ SN +++ L +L + S+ E+ N QL L+ D ++
Sbjct: 987 TKIDEL-RTLDSVSQI--SNIDLLNL-RDLSNGSE-----EDNLPNTQLDLLGND--YLV 1035
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
V + I+ N + +I + ++E ++ + S +S Q
Sbjct: 1036 SKQVKEYRIQEPNRENSFHSSIEAI-----------------WEECKE-IVKASSKKSHQ 1077
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
+ LE+QI+ L A K EN +L KE+ + DL +KE ++ +L+ +
Sbjct: 1078 I------EELEQQIEKLQAEVK--GYKDENNRL-KEKEHKNQDDLLKEKETLIQQLKEEL 1128
Query: 715 QE-NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
QE N+ L +++ + K +SEL + + AKI+E + +E + E
Sbjct: 1129 QEKNVTLDVQIQHVVEGKRALSELTQGVTCYK-----------AKIKELETILETQKVEC 1177
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
S +LE+ I E LER + +LQ+ K + ++E +L + L
Sbjct: 1178 ----SHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT 1233
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK-ANRTDLAE 890
++ + + K LL+++ E +E ++ L+E L S + Q L K + DL E
Sbjct: 1234 NNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNLKADLQRKEEDYADLKE 1290
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ T + Q++ ++ + + E + L + K E+E + + + +++ R + L E+
Sbjct: 1291 -KLTDAKKQIKQVQKEVSVMRDEDKLLRI-KINELEKKKNQCSQELDMKQRTIQQLKEQL 1348
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
++E +Q+Y+ ++LN+ + + M + L ++ ++ Q + E + E
Sbjct: 1349 NNQ-----KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ--EQTQVEQDQVLEAKLEE 1401
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
+ +L L++ E+ L K N +D KL +L+ E++ K+
Sbjct: 1402 VERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKK 1461
Query: 1071 LLDSK-----QHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISSTIEPMSDD 1124
L+ K Q E I +E ++ + K EM I + S ++ ++
Sbjct: 1462 WLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREE 1521
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQL---ETL 1181
+ + VQ++ E Q + ++ E S K+ T++ + K I + L
Sbjct: 1522 RDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS-KIETQIMDIKPKRISSADPDKL 1580
Query: 1182 NTE-LTGHDVVNQEQINQLKSKLE--QLNTEND 1211
TE L+ +++ +I L+ +++TEND
Sbjct: 1581 QTEPLSTSFEISRNKIEDGSVVLDSCEVSTEND 1613
Score = 58.8 bits (136), Expect = 1e-07
Identities = 173/971 (17%), Positives = 398/971 (40%), Gaps = 77/971 (7%)
Query: 158 LSVLQVKMKIMETTILDLQEKI-NEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQ 216
+ VLQ + + +L ++ ++ NEK++ E NK ++ +Q
Sbjct: 877 IRVLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELSLSEKKNLTLSKEVQQ 935
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLA 275
+Q N+ AE +K + ++ E K +++S+ +E A + + +I L H+K+
Sbjct: 936 ----IQSNYDIAIAELHVQKSKN-QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKI- 989
Query: 276 QELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLN 335
EL L S + E+ + L++ L K ++ E+
Sbjct: 990 DELRTLDSVSQISNIDLLNLRDLS---NGSEEDNLPNT-QLDLLGNDYLVSK-QVKEY-- 1042
Query: 336 CQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+I++ N+E + + + E K + S K S I + K+++ E
Sbjct: 1043 -RIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ--IEKLQAEVKGYKDEN 1099
Query: 394 LNQDTDKKINKNEIAK-LEMVIQSLNKDLVDKEYV----ISEKDTXXXXXXXXXXGKDTL 448
+ N++++ K E +IQ L ++L +K I G
Sbjct: 1100 NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY 1159
Query: 449 IAQL-QLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLKQ---ELNDEIKDVNVKD 500
A++ +LE + H +D+ E I K++ LK+ L D +K N KD
Sbjct: 1160 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK--NTKD 1217
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
L K +E+ITQL + + K+++++K + +Q + + ++S S+ L
Sbjct: 1218 LNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNL 1274
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKAISLL 619
+L + A+L+E+ + + + + D K + I++ L + + +
Sbjct: 1275 KADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC---- 1330
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSE--IKSVHLEEQIDALSASKKE 677
SQ+ D+ Q +QQ +++ ++ + + Q ++ C + +K +E+ L ++
Sbjct: 1331 -SQELDMKQRT--IQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1387
Query: 678 LALVIENLKLDKEQLYGTIKDLE------NDKEDIMNKLQNYIQEN-MDLTDKLEKMSAE 730
+ L+ E++ +LE ND E N+ N EN D+ KL + E
Sbjct: 1388 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1447
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+ E K N + + ++ + + + +E R+ ++ + ++ + +E A
Sbjct: 1448 -LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTA 1506
Query: 787 VMEDRRYSLER---KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ ++ L++ + DQL + L+ + KA +Q+D + +L ++ +E Q+++
Sbjct: 1507 QLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMD 1566
Query: 844 IEHENKELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY-----Q 897
I+ + +++ E + + +IS + ++ ++V + +ST++ +
Sbjct: 1567 IKPKRISSADPDKLQTEPLSTSFEISRNKIED--GSVVLDSCEVSTENDQSTRFPKPELE 1624
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
Q L+ N + H T V K + + + N E ++ + N N+++
Sbjct: 1625 IQFTPLQPNKMAVKHPGCTTPVTVKIP-KARKRKSNEMEEDLVKCENKKNATPRTNLKFP 1683
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ K + + ++ + + V + +++ + + ++
Sbjct: 1684 ISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSI 1743
Query: 1018 LKQKDEEIIAL--NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
L+ K ++II + K++N + S ++ +K +T+++ + + +V L+D K
Sbjct: 1744 LQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVI--LMDQK 1801
Query: 1076 QHNEELQILVR 1086
+ QI+ R
Sbjct: 1802 MKESDHQIIKR 1812
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 1207 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 1265
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 1266 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 1321
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 1322 ELEKKKNQCSQELD 1335
>AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 89.4 bits (212), Expect = 9e-17
Identities = 223/1106 (20%), Positives = 463/1106 (41%), Gaps = 102/1106 (9%)
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEE----QITQLNDEIDAA---NKNMIKVKSNHKLK-- 536
+ L D ++D +DL+E+L++AEE + L++++D NK I + KL
Sbjct: 523 ENSLEDLMED---EDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDL 579
Query: 537 LKQMQKTIDNFSKVSDSNKEIVR--LTEEL-HHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
++ ++K + N K + + +R +T+E + +Q+ A+ +E + L + R+
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 594 -IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED--KLADISQL 650
I D+ K E A+ + A + + + V I+ D V D K A+I+ L
Sbjct: 640 AIFKDLVGKCDTREEAAKD-ICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAEIAHL 698
Query: 651 --------QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
Q C E+K ++ + L+ +K EL E LK + + I++LE
Sbjct: 699 YIASLPDPQEATACLELKFNQIKAE---LAKTKGELIKTKEELKKRENESDSLIQELETS 755
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS-KIQTQFGIDAKIQERD 761
+ I+ + Q I+E +++ D+ E + I+E +H E + K + + I
Sbjct: 756 NKKIITQNQR-IKELINIIDQKE----DTINEFQNLKSHMENTFKCNDKADTSSLIINNK 810
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTIQ 819
L KS+IC + + E ++ K + S + E QK E
Sbjct: 811 LICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPN 870
Query: 820 EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNAL 879
E+ + + VL +++ + LL IE+E K + EE L + QQ + L
Sbjct: 871 IAEIED-IRVLQENNEGLRAFLLTIENELKNEK-------EEKAELNKQIVHFQQELS-L 921
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IES 938
EK N T E + + + E ++++ ++ Q + K EIE T+ I +
Sbjct: 922 SEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSN----EIETATRSITN 977
Query: 939 AIRDKKVLNEKYE--KNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKM-NLELIDK 991
+ K+++ K + + ++ V+Q+ L++ N E N+ +L+ + N L+ K
Sbjct: 978 NVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSK 1037
Query: 992 HVQKQQTQSPDYTEQYINEINKL----NALLK---QKDEEIIALNQKINNAQVSYMSMVS 1044
V++ + Q P+ + + I + ++K +K +I L Q+I Q
Sbjct: 1038 QVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY-K 1096
Query: 1045 DYESKLAQFTTK-LENMEEEMQRVSKQLLDSKQH-NEELQILVR---EQDDQIKELKETK 1099
D ++L + K +++ +E + + +QL + Q N L + ++ E + EL +
Sbjct: 1097 DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV 1156
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER----S 1155
++ I + E ++ + +E D ++E +E +Q+
Sbjct: 1157 TCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK 1216
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
L + KL E+ + + ++ L + N+++ +LK +L + NL
Sbjct: 1217 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK- 1275
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHEL-RVQLSAFESKYEQL-- 1271
A+L+ D + ++ + KQ Q+E + E +L R++++ E K Q
Sbjct: 1276 --ADLQRKEEDYADLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQ 1332
Query: 1272 -LDSVQSSTQ---EETNKIVTMEQVTSLQNKLQD---KEEHLRNLQEKYADVINQIEILR 1324
LD Q + Q E+ N E + + +D KE+ + +++ + Q ++ +
Sbjct: 1333 ELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ-EQTQVEQ 1391
Query: 1325 SEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXX 1384
++ + K+ DL T+N + ++ ++ + L+
Sbjct: 1392 DQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQ 1449
Query: 1385 XXXXXXXXXRVNDAEAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
R E K++ +T E +++ E+ + + Q+N E E + QL
Sbjct: 1450 ESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN-EMEILTAQL 1508
Query: 1442 VEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
E + ++ E++ +A L +++ A +QK++EIE++K I KI E+ +
Sbjct: 1509 TEKDSDLQKWREERDQLVAALEIQL--KALISSNVQKDNEIEQLKRIISETSKI-ETQIM 1565
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALE 1527
+ + ++ A + + +T + T+ E
Sbjct: 1566 DIKPKRISSA-DPDKLQTEPLSTSFE 1590
Score = 87.0 bits (206), Expect = 5e-16
Identities = 205/1041 (19%), Positives = 431/1041 (41%), Gaps = 105/1041 (10%)
Query: 562 EELHHLSQKVAELE--EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
E+L V ELE EE N++ L+D D + +E + K I E + K + L+
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEEN--KAFISHEE----KRKLLDLI 580
Query: 620 ESQKFDLVQEL-HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
E K L+ E L ++ E+ + +Q + + ++ K L+E+ + L + +
Sbjct: 581 EDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQRE-ADFKETLLQER-EILEENAERR 638
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ ++L + KD+ K + + NY+ D+ D L+ A+ + A+
Sbjct: 639 LAIFKDLVGKCDTREEAAKDICATKVET-EETHNYVGFE-DIIDSLQDNVADIKKQ--AE 694
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
I H + + A ++ L I++EL+K K + + +E L+++
Sbjct: 695 IAHLYIASLPDPQEATACLE---LKFNQIKAELAKTKGELIKTKEE----------LKKR 741
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
++ S +QE + + ++ I +++ + L ++D +K+ E +N + +N
Sbjct: 742 ENESDSLIQELETS-NKKIITQNQRIKELINIID-----QKEDTINEFQNLKSHMENTFK 795
Query: 859 LEENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + + + + N VE K +++ + + +L+ E K+ + +
Sbjct: 796 CNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSS 855
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
I + +K+ E++ + I D +VL E E ++ +E +L+ K LN
Sbjct: 856 AITEDQKKSEEVRPNI-----AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK 910
Query: 977 NVEELNKMNLELIDKH---VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
+ + L L +K + K+ Q + I E++ + ++++E+I+ L+ +I
Sbjct: 911 QIVHFQQ-ELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 969
Query: 1034 NAQVSYMSMVSDYE---SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
A S + VS + +K+ + T L+++ + L D +EE + + D
Sbjct: 970 TATRSITNNVSQIKLMHTKIDELRT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 1028
Query: 1091 QIKELKETKLTFEMNI--PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ--- 1145
+ +K E I P E SS IE + ++ + L+ Q
Sbjct: 1029 LGNDYLVSKQVKEYRIQEPNRENSFHSS-IEAIWEECKEIVKASSKKSHQIEELEQQIEK 1087
Query: 1146 ---EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
E + + E + L+E+ K +L + +IQ L EL +V QI +
Sbjct: 1088 LQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQ--QLKEELQEKNVTLDVQIQHVVEG 1145
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQREADFQKTEHELRVQ 1260
L+ + A+++ + + ++ + E + K Q + ++E+ K E L+
Sbjct: 1146 KRALSELTQGVTCYKAKIKE-LETILETQKVECSHSAKLEQDILEKESIILKLERNLK-- 1202
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
F+ E L DSV+++ ++ E++T L N LQD +HL L+E+ + Q
Sbjct: 1203 --EFQ---EHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ- 1255
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
E EK+ DL+ + + Y ++E+ + + ++ Q++K
Sbjct: 1256 -------ETEKL--KEELSASSARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQKE 1305
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
++N+ E K + + +L++K I Q Q N+ + V +
Sbjct: 1306 VSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE-------QLNN--QKVEEA 1356
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVS 1500
+ +YE+ +DL KE + +R+ + E +T ++ ++ KL EE+ TE
Sbjct: 1357 IQQYERACKDLNV-KEKIIEDMRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATELEK 1411
Query: 1501 LNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK-IQKHVS 1559
++ +L + K +E T + ++ L DE+ + A K +++ +
Sbjct: 1412 WKEKCNDLETKNNQRSNKEHENNTDVLG---KLTNLQDELQESEQKYNADRKKWLEEKMM 1468
Query: 1560 FASDTKQGRDEQLDNTMNKEL 1580
+ K+ +N NKE+
Sbjct: 1469 LITQAKEA-----ENIRNKEM 1484
Score = 82.6 bits (195), Expect = 1e-14
Identities = 161/753 (21%), Positives = 334/753 (44%), Gaps = 87/753 (11%)
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL-- 535
++K +Q++ + I +++V+ K + EE+I +L++EI+ A +++ S KL
Sbjct: 929 LSKEVQQIQSNYDIAIAELHVQK--SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 986
Query: 536 -KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K+ ++ +T+D+ S++ SN +++ L +L + S+ E+ N QL L+ D ++
Sbjct: 987 TKIDEL-RTLDSVSQI--SNIDLLNL-RDLSNGSE-----EDNLPNTQLDLLGND--YLV 1035
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
V + I+ N + +I + ++E ++ + S +S Q
Sbjct: 1036 SKQVKEYRIQEPNRENSFHSSIEAI-----------------WEECKE-IVKASSKKSHQ 1077
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
+ LE+QI+ L A K EN +L KE+ + DL +KE ++ +L+ +
Sbjct: 1078 I------EELEQQIEKLQAEVK--GYKDENNRL-KEKEHKNQDDLLKEKETLIQQLKEEL 1128
Query: 715 QE-NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
QE N+ L +++ + K +SEL + + AKI+E + +E + E
Sbjct: 1129 QEKNVTLDVQIQHVVEGKRALSELTQGVTCYK-----------AKIKELETILETQKVEC 1177
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
S +LE+ I E LER + +LQ+ K + ++E +L + L
Sbjct: 1178 ----SHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT 1233
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK-ANRTDLAE 890
++ + + K LL+++ E +E ++ L+E L S + Q L K + DL E
Sbjct: 1234 NNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNLKADLQRKEEDYADLKE 1290
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ T + Q++ ++ + + E + L + K E+E + + + +++ R + L E+
Sbjct: 1291 -KLTDAKKQIKQVQKEVSVMRDEDKLLRI-KINELEKKKNQCSQELDMKQRTIQQLKEQL 1348
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
++E +Q+Y+ ++LN+ + + M + L ++ ++ Q + E + E
Sbjct: 1349 NNQ-----KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ--EQTQVEQDQVLEAKLEE 1401
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
+ +L L++ E+ L K N +D KL +L+ E++ K+
Sbjct: 1402 VERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKK 1461
Query: 1071 LLDSK-----QHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISSTIEPMSDD 1124
L+ K Q E I +E ++ + K EM I + S ++ ++
Sbjct: 1462 WLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREE 1521
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQL---ETL 1181
+ + VQ++ E Q + ++ E S K+ T++ + K I + L
Sbjct: 1522 RDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS-KIETQIMDIKPKRISSADPDKL 1580
Query: 1182 NTE-LTGHDVVNQEQINQLKSKLE--QLNTEND 1211
TE L+ +++ +I L+ +++TEND
Sbjct: 1581 QTEPLSTSFEISRNKIEDGSVVLDSCEVSTEND 1613
Score = 58.8 bits (136), Expect = 1e-07
Identities = 173/971 (17%), Positives = 398/971 (40%), Gaps = 77/971 (7%)
Query: 158 LSVLQVKMKIMETTILDLQEKI-NEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQ 216
+ VLQ + + +L ++ ++ NEK++ E NK ++ +Q
Sbjct: 877 IRVLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELSLSEKKNLTLSKEVQQ 935
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISS-LEEANKLLEAARFEISLEHSKLA 275
+Q N+ AE +K + ++ E K +++S+ +E A + + +I L H+K+
Sbjct: 936 ----IQSNYDIAIAELHVQKSKN-QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKI- 989
Query: 276 QELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLN 335
EL L S + E+ + L++ L K ++ E+
Sbjct: 990 DELRTLDSVSQISNIDLLNLRDLS---NGSEEDNLPNT-QLDLLGNDYLVSK-QVKEY-- 1042
Query: 336 CQIRQTNKE--LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+I++ N+E + + + E K + S K S I + K+++ E
Sbjct: 1043 -RIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ--IEKLQAEVKGYKDEN 1099
Query: 394 LNQDTDKKINKNEIAK-LEMVIQSLNKDLVDKEYV----ISEKDTXXXXXXXXXXGKDTL 448
+ N++++ K E +IQ L ++L +K I G
Sbjct: 1100 NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCY 1159
Query: 449 IAQL-QLEHQQHMEGPSLIHVGTNTEDVNE----IAKVQEQLKQ---ELNDEIKDVNVKD 500
A++ +LE + H +D+ E I K++ LK+ L D +K N KD
Sbjct: 1160 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK--NTKD 1217
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL 560
L K +E+ITQL + + K+++++K + +Q + + ++S S+ L
Sbjct: 1218 LNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNL 1274
Query: 561 TEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKAISLL 619
+L + A+L+E+ + + + + D K + I++ L + + +
Sbjct: 1275 KADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC---- 1330
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSE--IKSVHLEEQIDALSASKKE 677
SQ+ D+ Q +QQ +++ ++ + + Q ++ C + +K +E+ L ++
Sbjct: 1331 -SQELDMKQRT--IQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1387
Query: 678 LALVIENLKLDKEQLYGTIKDLE------NDKEDIMNKLQNYIQEN-MDLTDKLEKMSAE 730
+ L+ E++ +LE ND E N+ N EN D+ KL + E
Sbjct: 1388 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1447
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQE----RDLYIENIESELSKYKSRICRLEESIA 786
+ E K N + + ++ + + + +E R+ ++ + ++ + +E A
Sbjct: 1448 -LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTA 1506
Query: 787 VMEDRRYSLER---KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ ++ L++ + DQL + L+ + KA +Q+D + +L ++ +E Q+++
Sbjct: 1507 QLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMD 1566
Query: 844 IEHENKELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY-----Q 897
I+ + +++ E + + +IS + ++ ++V + +ST++ +
Sbjct: 1567 IKPKRISSADPDKLQTEPLSTSFEISRNKIED--GSVVLDSCEVSTENDQSTRFPKPELE 1624
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
Q L+ N + H T V K + + + N E ++ + N N+++
Sbjct: 1625 IQFTPLQPNKMAVKHPGCTTPVTVKIP-KARKRKSNEMEEDLVKCENKKNATPRTNLKFP 1683
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ K + + ++ + + V + +++ + + ++
Sbjct: 1684 ISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSI 1743
Query: 1018 LKQKDEEIIAL--NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
L+ K ++II + K++N + S ++ +K +T+++ + + +V L+D K
Sbjct: 1744 LQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVI--LMDQK 1801
Query: 1076 QHNEELQILVR 1086
+ QI+ R
Sbjct: 1802 MKESDHQIIKR 1812
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 1207 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 1265
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 1266 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 1321
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 1322 ELEKKKNQCSQELD 1335
>AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens cDNA
FLJ46736 fis, clone TRACH3020769, weakly similar to
Myosin heavy chain, nonmuscle type B. ).
Length = 1080
Score = 89.4 bits (212), Expect = 9e-17
Identities = 158/846 (18%), Positives = 366/846 (43%), Gaps = 61/846 (7%)
Query: 518 EIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
EID K SN K K+K +++D+ ++ S+ E EL H S K L E
Sbjct: 212 EIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSS-ETASEDCELPHSSYKNFMLLIE 270
Query: 578 KGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKY 637
QL + DS +++ + + E L E + LL + + ++++LQ++
Sbjct: 271 ----QLGMECKDSVSLLK--IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQREL 324
Query: 638 DEVEDKLADISQLQSD---QVCSEIKSVHLEEQ----IDALSAS-KKELALVIENLKLD- 688
E ++ + + + + ++CS S++ EE+ D L +++L E + +
Sbjct: 325 SETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV 384
Query: 689 --KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
K+QL +++ LE + + + L +QE D +L + ++ + NH +Q
Sbjct: 385 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQK 444
Query: 746 KIQ-TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
+I+ Q ++++ +++ + S + I L I ++++ E+K +
Sbjct: 445 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLK 504
Query: 805 YLQEKQKAYSEYTIQEDELV--------NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
++EK + + Q +E + RL+VL + ++ +L E+E + ++
Sbjct: 505 IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKL---ENEKQSKERLEA 561
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + L ++ D Q + E A E ++ Q ++ SNLK
Sbjct: 562 EVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ 621
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
+ + + ++ LEIEF+ A+R+K + E+ +K++ +Q + Q++E + +N +
Sbjct: 622 QLFKTESKLNSLEIEFH-HTRDALREKTLGLERVQKDL---SQTQCQMKEMEQKYQNEQV 677
Query: 977 NVEE-LNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
V + + K E +++ + + Q+++ +Q + NK + K++ +I + + +A
Sbjct: 678 KVNKYIGKQ--ESVEERLSQLQSENMLLRQQLDDAHNKAD----NKEKTVINIQDQF-HA 730
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
V + S+ +S L + K + E + ++ + E +++VR+ ++ +
Sbjct: 731 IVQKLQAESEKQSLLLEERNK--ELISECNHLKERQYQYENEKAEREVVVRQLQQELADT 788
Query: 1096 KETKLTFEMNIPKTEGMIIS--STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
+ + E ++ T I+ + + + V+ E+
Sbjct: 789 LKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTE-AVRCAEKMQDH 847
Query: 1154 RSVLQEQSAKLNTELQECYTKI--IQLETLNTELTGHDVVNQEQINQLKSKLE-QLNTEN 1210
+ L++ +AKL +++ KI +Q LN L+ + +++ +LK LE L E
Sbjct: 848 KQKLEKDNAKLKVTIKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLGQEM 907
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQ 1270
+ E+ + + + ++ E ++ D + ++ E+ +Q++ + K +
Sbjct: 908 KKNVELEREI-TGFKNLLKMTRKKLNE-YENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 965
Query: 1271 LLDSVQSSTQE----ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE 1326
L ++++ + +T + E++ S++ + E+ +N ++ +VIN LRS
Sbjct: 966 LTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN----LRSH 1021
Query: 1327 IEDEKV 1332
IE V
Sbjct: 1022 IERNMV 1027
Score = 80.2 bits (189), Expect = 6e-14
Identities = 175/887 (19%), Positives = 358/887 (40%), Gaps = 101/887 (11%)
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISE--LLAKINHEEQSKIQTQFGIDAKIQERDLYIE 765
NK++N IQ +MD D L + S+E SE L +++ + Q G++ K L I+
Sbjct: 229 NKVKNQIQ-SMDDVDDLTQ-SSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQ 286
Query: 766 NIE---SELSKYKSRICRL-EESIAVMEDRRYSLERKADQ---LGSYLQ------EKQKA 812
+ L + K C L I MED+ L+R+ + + S L+ E++
Sbjct: 287 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 346
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+++ ++E R A + ++++ E+ + E KE++ K Q+ L Q L++ L +
Sbjct: 347 SLRFSLNQEEEKRRNADTL-YEKIREQLRRKEEQYRKEVEVKQQLELSL-QTLEMELRTV 404
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEF 932
+ + N +V++ N Q QL E N + + T + K+KEIE + +
Sbjct: 405 KSNLNQVVQERNDA----------QRQL-SREQNARMLQDGILTNHLSKQKEIEMAQKKM 453
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N++ + ++K L+ K E + L ++ + I+N N E+ +L+++ +
Sbjct: 454 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCFEDLKIVKEK 509
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+ Q E I++ N L E LN K+ N + S + ++ ES ++
Sbjct: 510 NEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSR 569
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + ++ + L ++ +E L + + + LK+ + KTE
Sbjct: 570 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK 629
Query: 1113 IISSTIE------PMSDDANNVDXXXXXXXXXXXXLKVQEE---------------EEFI 1151
+ S IE + + ++ +K E+ +E +
Sbjct: 630 LNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESV 689
Query: 1152 QER-SVLQEQSAKLNTELQECYTKIIQLE--TLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+ER S LQ ++ L +L + + K E +N + H +V + Q K L L
Sbjct: 690 EERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL-LLEE 748
Query: 1209 ENDNLLSTVAEL----------RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH--- 1255
N L+S L ++ V Q E+A+ K+ + EA + T
Sbjct: 749 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRI 807
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L + + K Q+ + +Q + T + E++ + KL+ L+ +K D
Sbjct: 808 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTIKKQMD 867
Query: 1316 VINQIE--ILRSEI-EDEK------VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS 1366
I +++ +L + + EDEK + +L E +K + + +
Sbjct: 868 KIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLGQEMKKNVELEREITGFKNLLKMT 927
Query: 1367 ILNINE-ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+NE EN + ++N + K+ +LT +LE S+ +
Sbjct: 928 RKKLNEYENGEF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSK--------CL 978
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKES-ELAILRLKMHENANHYETMQKESEIER 1484
L +N + + +K+ E L K+ E ++ L+ H N M + ++++
Sbjct: 979 HLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERN----MVELGQVKQ 1034
Query: 1485 VKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
K +E+ + + ++ +++ E+N L+ + A ++ E Q++
Sbjct: 1035 YK--QEIEERARQEIA--EKLKEVNLFLQAQAASQENLEQLREKQDL 1077
Score = 74.1 bits (174), Expect = 4e-12
Identities = 135/734 (18%), Positives = 320/734 (43%), Gaps = 68/734 (9%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQ 539
K++EQL+++ K+V VK +E + L E+ N+ +V +Q
Sbjct: 368 KIREQLRRKEEQYRKEVEVKQQLEL------SLQTLEMELRTVKSNLNQVVQERNDAQRQ 421
Query: 540 MQKTIDNFSKVSDSNKEIVRLTEELHHLS-QKVAELEEEKGNLQ-LHLVDYDSGRMIESD 597
+ + + N +++ +HLS QK E+ ++K N + H + + ++
Sbjct: 422 LSR---------EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNS 472
Query: 598 VYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCS 657
+ ++ I M L +K + + +K ++L I+++K ++++ + Q+++ +
Sbjct: 473 MLQEEIAMLRLEIDTIKNQNQEKEKK--CFEDLKIVKEKNEDLQKTIK-----QNEETLT 525
Query: 658 EIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
+ S + ++ L+A L +EN K KE+ LE + E ++L I
Sbjct: 526 QTISQY-NGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH-- 575
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID-AKIQERDLYIENIESELSKYKS 776
D+ + ++++ EL + +E S++Q + D + +++ + E + +L K +S
Sbjct: 576 ----DRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN---EILSQQLFKTES 628
Query: 777 RICRLE----ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMD 832
++ LE + + ++ LER L S Q + K + E VN+ +
Sbjct: 629 KLNSLEIEFHHTRDALREKTLGLERVQKDL-SQTQCQMKEMEQKYQNEQVKVNK---YIG 684
Query: 833 HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE 892
VE++L +++ EN L+++ + N + ++ ++Q ++A+V+K +E +
Sbjct: 685 KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE--SEKQ 742
Query: 893 STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEK 952
S + + ++L S + E Q +K E E + + ++ ++ + + E
Sbjct: 743 SLLLEERNKELISECNHL-KERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEV 801
Query: 953 NIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
Y LE + Q+ K + + ++E + E + + +K Q D+ ++ +
Sbjct: 802 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-RCAEKMQ----DHKQKLEKDNA 856
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLL 1072
KL +K++ ++I L + + NA +S D + +L + +++E + + K+ +
Sbjct: 857 KLKVTIKKQMDKIEELQKNLLNANLS-----EDEKEQLKKLMELKQSLECNLGQEMKKNV 911
Query: 1073 DSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ ++ + L++ ++ E + + +F ++ KT + I + + D
Sbjct: 912 ELEREITGFKNLLKMTRKKLNEYENGEFSFHGDL-KTSQFEMDIQINKLKHKID--DLTA 968
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL-TGHDVV 1191
L + + + +QE + + K +LQ+ K+ Q E +N ++V
Sbjct: 969 ELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQ-EVINLRSHIERNMV 1027
Query: 1192 NQEQINQLKSKLEQ 1205
Q+ Q K ++E+
Sbjct: 1028 ELGQVKQYKQEIEE 1041
Score = 72.1 bits (169), Expect = 2e-11
Identities = 165/910 (18%), Positives = 358/910 (39%), Gaps = 71/910 (7%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHS 272
D ++++ E+ + +EK ++ I+S D +++ + E A + L HS
Sbjct: 205 DDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMD----DVDDLTQSSETASEDCELPHS 260
Query: 273 KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKG-SLEIANMTELTKKIELL 331
+ L Q SCE E+++ L + ++ K+ +L
Sbjct: 261 SYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVL 320
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ + ++ +LE++ E + S R++ K++ +
Sbjct: 321 QRELSETKEIKSQLEHQKVEW--ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 378
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK------ 445
+ + K+ + + LEM ++++ +L V+ E++ +
Sbjct: 379 QYRKEVEVKQQLELSLQTLEMELRTVKSNL---NQVVQERNDAQRQLSREQNARMLQDGI 435
Query: 446 --DTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQ---LKQELNDEIKDVNV- 498
+ L Q ++E Q H +D++ + + +QE+ L+ E+ D IK+ N
Sbjct: 436 LTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI-DTIKNQNQE 494
Query: 499 --KDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKLKQMQKTIDNFSKVSDSN 554
K E LK +E+ L I + + + S N +L + + + N SK+ +
Sbjct: 495 KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLN-SKLENEK 553
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+ RL E+ ++A ++ + + + D ++ + N + LK
Sbjct: 554 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLK 613
Query: 615 AIS-LLESQKFDLVQELHILQQKY----DEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
+ +L Q F +L+ L+ ++ D + +K + ++Q D ++ + +E++
Sbjct: 614 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQ 673
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK----LE 725
+ E+++ QL L +D NK N + +++ D+ ++
Sbjct: 674 NEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQ 733
Query: 726 KMSAE--KISELLAKINHEEQSKI----QTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
K+ AE K S LL + N E S+ + Q+ + + ER++ + ++ EL+ +
Sbjct: 734 KLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQS 793
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK 839
E S+ V R +LE + L L + + E + E V + DH + +EK
Sbjct: 794 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 853
Query: 840 QLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+++ K+ K + L + N +S D ++ L+E + + K +
Sbjct: 854 DNAKLKVTIKKQMDKIEELQKNLLNANLS-EDEKEQLKKLMELKQSLECNLGQEMKKNVE 912
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L + K + + +K E E+ E F+ ++++ ++E +I
Sbjct: 913 LEREITGFKNLL----KMTRKKLNEYENGEFSFHGDLKTS---------QFEMDI----- 954
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
Q+ + K+ I++L +E L L K+ Q+ T Q + KL K
Sbjct: 955 ---QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQ--KKCEKLQKNKK 1009
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE 1079
+ ++E+I L I V + V Y+ ++ + + + E+++ V+ L E
Sbjct: 1010 KLEQEVINLRSHIERNMVE-LGQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAASQE 1066
Query: 1080 ELQILVREQD 1089
L+ L +QD
Sbjct: 1067 NLEQLREKQD 1076
Score = 48.0 bits (109), Expect = 3e-04
Identities = 107/638 (16%), Positives = 268/638 (42%), Gaps = 44/638 (6%)
Query: 143 DVTHLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXX 202
D++H ++ ++E+ +++L++++ ++ + ++K E +I++ KN+
Sbjct: 466 DLSHKNSMLQEE---IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 522
Query: 203 XXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEA 262
+T + K K+RL ++ES R+++ E
Sbjct: 523 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 582
Query: 263 ARFEISLEHSKLAQE---LEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIA 319
++ E+ L + E L+ + Q + + + +E +
Sbjct: 583 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRD 642
Query: 320 NMTELTKKIEL----LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKS- 374
+ E T +E L CQ+++ ++ +N+ + S ++ S L S
Sbjct: 643 ALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENML 702
Query: 375 GRNTASKMKSPWSQLSSETLN-QDTDKKINKN---EIAKLEMVIQSLNKDLVDKEYVISE 430
R + +N QD I + E K ++++ NK+L+ + + E
Sbjct: 703 LRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKE 762
Query: 431 KDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG---TNTEDVNEIAKVQEQLKQ 487
+ ++ ++ QLQ E ++ S+ T+ +N + Q+ LK+
Sbjct: 763 RQ---YQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQD-LKK 818
Query: 488 ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL---KLKQMQKTI 544
+L +I++ +++ ++ A ++ D K+ K+K K K++++QK +
Sbjct: 819 KLG-QIRN-QLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTIKKQMDKIEELQKNL 876
Query: 545 DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIE 604
N + D +++ +L E L + +E K N++L + + + KK+ E
Sbjct: 877 LNANLSEDEKEQLKKLMELKQSLECNLG--QEMKKNVELER-EITGFKNLLKMTRKKLNE 933
Query: 605 MENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHL 664
EN L++ +F++ +++ L+ K ++D A++ S + + K+ L
Sbjct: 934 YEN---GEFSFHGDLKTSQFEMDIQINKLKHK---IDDLTAELETAGSKCLHLDTKNQIL 987
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
+E++ ++ +K+ + +N K ++++ +E + + + +++ Y QE +
Sbjct: 988 QEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE-LGQVKQYKQE-------I 1039
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDL 762
E+ + ++I+E L ++N Q++ +Q ++ +++DL
Sbjct: 1040 EERARQEIAEKLKEVNLFLQAQAASQENLEQLREKQDL 1077
>AF302773-1|AAG33512.2| 2090|Homo sapiens ninein-Lm isoform protein.
Length = 2090
Score = 89.4 bits (212), Expect = 9e-17
Identities = 235/1177 (19%), Positives = 485/1177 (41%), Gaps = 120/1177 (10%)
Query: 458 QHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN--VKDLIEKLKSAEEQITQL 515
Q +EG + E E E K EL E + +K+ +++ K+ +TQ
Sbjct: 834 QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS--NKEIVRL-TEELHHLSQKVA 572
+ ++ K + + +L Q + + N S+ S + +I+ L + + L ++
Sbjct: 894 REMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHIRELREREE 953
Query: 573 EL-----EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLV 627
L E+ + +L ++ + + ++ K++ MEN+ + + + ++ ++
Sbjct: 954 VLCQAGASEQLASQRLERLEMEHAQE-RQEMMSKLLAMENIHKATCETA---DRERAEMS 1009
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN--- 684
E+ LQ K E++ + +S LQS C I +E ALS + L+ EN
Sbjct: 1010 TEISRLQSKIKEMQQATSPLSMLQSG--CQVIGEEEVEGD-GALSLLHQGEQLLEENGDV 1066
Query: 685 -LKLDK--EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN- 740
L L + EQ + + + +LQ ++ + ++ L++ + E +
Sbjct: 1067 FLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATEFFGNTAEQTEP 1125
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+Q++ + G+ + DL + + S S + R E I E+ S+E ++
Sbjct: 1126 FLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKI---EESEASVEGFSE 1182
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLM-DHDRVVEKQ---LLEIEHENKELQKKNQ 856
S +E + E Q +L +L +L D DR EK+ L ++ K+L+ +
Sbjct: 1183 LENS--EETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1240
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKAN----RTDLAESESTKYQTQLRDLESNLKRITH 912
I E + ++ D+ + + L E+ R D A + + ++ L+ LK++
Sbjct: 1241 IP-EASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEE 1299
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
+T + +K ++++IE N ++ + L K EK E V Q ++ ++E
Sbjct: 1300 VTETFL-SLEKSYDEVKIE-NEELNVLVLR---LQGKIEKLQESVVQ-RCDCCLWEASLE 1353
Query: 973 NLNM----NVEELNKMNLELIDK-----HVQKQQTQSPDYTE---QYI-----NEINKLN 1015
NL + N+ +LN+ E + + HV ++ Q Y E Q + +EI L+
Sbjct: 1354 NLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLH 1413
Query: 1016 ALLKQKDEEIIALNQKI---NNAQVSYMSMVSDYESKLAQFT---TKLENMEEEM-QRVS 1068
++ E NQ I N + + +++ +A+ TKL+ + ++ +RV+
Sbjct: 1414 GTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVT 1473
Query: 1069 -----KQLLDSKQHNEELQILVREQDDQIKELKETK--LTFEMNIPKTEGMIISSTIEPM 1121
K +L + EEL+ ++ + E+++ L +E + E I+ + I +
Sbjct: 1474 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1533
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+++ +++ Q+ E QE + +Q+ L ++ E K QL+
Sbjct: 1534 NEE-DSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
Query: 1182 NTELTGHDVVNQEQINQL----------------KSKLEQLNTENDNLLSTVAELRSSIS 1225
NTEL+ + NQE++ +L S LE+ E NL + + S
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
Query: 1226 SAVDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE- 1281
+ V E++E+ Q H+ Q+E K E E QL S ++Q + SV S ++
Sbjct: 1653 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
Query: 1282 ETNKIVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEI--EDEKVA-FX 1335
K E++ S +KL E + ++++ +Q L+S++ EKV
Sbjct: 1713 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1772
Query: 1336 XXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
DLR Q K+ +Q +++++++ S
Sbjct: 1773 DTVQNVNLQMSRMKSDLRVTQQE-KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN 1831
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
+L H + + ++Q+ +E T+ Q N + +L +++ L
Sbjct: 1832 QQKRLSWDKLDHLMNEEQQLLWQE-NERLQTMVQ------NTKAELTHSREKVRQL---- 1880
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ES L L H+ + +E E++ L E + E N++V+++N +LE+E
Sbjct: 1881 ESNL----LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQE 1935
Query: 1516 VAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSS 1552
+ + L+ +++++ E+ +L++ S S
Sbjct: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS 1972
Score = 83.8 bits (198), Expect = 5e-15
Identities = 132/630 (20%), Positives = 284/630 (45%), Gaps = 48/630 (7%)
Query: 492 EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS-KV 550
E++ +++L KLK E++T L + D + + + K + +Q T KV
Sbjct: 1455 ELEKTKLQELTRKLK---ERVTILVKQKDVLSHG--EKEEELKAMMHDLQITCSEMQQKV 1509
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKG--NLQLHLVDYDSGRMIESD--VYKKMIEME 606
E +L +E L ++ L EE NL+L ++ M + V ++ ++
Sbjct: 1510 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1569
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E K IS L+ + L E L QK + ++KL +++Q ++ +C + K E
Sbjct: 1570 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK----EP 1625
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI--QENMDLTDKL 724
AL ++E + E L+ K Q + LE + ++ K+Q +I QEN L D+L
Sbjct: 1626 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDEL 1683
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEE 783
EKM L+ Q KI + + K+ +E++ E + S + K ++ LE
Sbjct: 1684 EKMKQLHRCPDLSDF----QQKISSVLSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEH 1738
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQL 841
IA M+ + S E ++ L S L Q+ E T+Q L +++ + RV +++
Sbjct: 1739 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL--QMSRMKSDLRVTQQEK 1796
Query: 842 LEIEHENKELQKKNQILLEENQNLQIS-----LSDMQQH--YNALVEKANRTD-LAESES 893
++ E L K+ Q ++ +I+ L + Q+ ++ L N L E+
Sbjct: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1856
Query: 894 TKYQTQLRDLESNL----KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ QT +++ ++ L +++ L+ + +K + T+ E ++ ++
Sbjct: 1857 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC--DQ 1914
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-----HVQKQQTQSPDYT 1004
++K + +Q+ + +E +++ E L K ++L ++ H++ T SP
Sbjct: 1915 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS-P 1973
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+ ++ + A E+ + L +++ A+ + + E++ ++ T N E+ +
Sbjct: 1974 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLV 2033
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ +++++ +Q + ++ L++E+ +Q+KE
Sbjct: 2034 TVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2063
Score = 67.3 bits (157), Expect = 4e-10
Identities = 168/845 (19%), Positives = 332/845 (39%), Gaps = 57/845 (6%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAA---NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+D+ + +E++ + D A NK + + +LK+M++ + F + S
Sbjct: 1253 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD 1312
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ EEL+ L V L+ + LQ +V + E+ + IE + L+
Sbjct: 1313 EVKIENEELNVL---VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG---NILQL 1366
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE + V+ +H + ++ + L +QL EI +H Q
Sbjct: 1367 NQTLE-ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV 1425
Query: 676 KELALVIENLKL----DKE-QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
+ ++ EN L DK Q TI +LE +K + + + L + + +S
Sbjct: 1426 QNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1485
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
+ E L + H+ Q T + K++ E ++ E S ++ I L E ++
Sbjct: 1486 EKEEELKAMMHDLQI---TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ +L +++ + ++ + + L +++ L ++ ++ + E+ +N +
Sbjct: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602
Query: 851 LQKKNQILLEENQNLQISLSDMQQH--YNALVEKANRTDLAESESTKYQTQLRDLESNLK 908
Q+K L E NQ L L ++ +AL E+ + E + + Q L S+L+
Sbjct: 1603 NQEK---LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLE 1659
Query: 909 RITHE--HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
E QT IVQ++ + E+E Q+ D +K + Y +L L+E
Sbjct: 1660 AELSEVKIQTHIVQQENHLLKDELEKMKQLHRC-PDLSDFQQKISSVLSYNEKL---LKE 1715
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
+ E LN V++L K + L++ + + + + Q + L + L E++
Sbjct: 1716 KEALSEELNSCVDKLAKSS--LLEHRIATMKQEQKSWEHQSAS----LKSQLVASQEKVQ 1769
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS--KQHNEELQIL 1084
L + N + M SD L + E +++E+ + KQL ++ K E+
Sbjct: 1770 NLEDTVQNVNLQMSRMKSD----LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATH 1825
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
+Q K L KL MN E ++ E + N L
Sbjct: 1826 PSGLHNQQKRLSWDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQL-- 1880
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E + + S +N QE + + + E + + Q+N L+ +LE
Sbjct: 1881 --ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPAN-RKVSQMNSLEQELE 1937
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEI----AELWKQHLAQREA-DFQKTEH--EL 1257
++ EN+ L +L + R W L Q++A E +L
Sbjct: 1938 TIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQL 1997
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADV 1316
+ QL E + L + +++ T E EQ VT ++ ++ + E+ L+ ++ +
Sbjct: 1998 QRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEK 2057
Query: 1317 INQIE 1321
+NQ++
Sbjct: 2058 VNQLK 2062
Score = 62.1 bits (144), Expect = 2e-08
Identities = 212/1116 (18%), Positives = 446/1116 (39%), Gaps = 79/1116 (7%)
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
H + + K+ E+ K+ + +K+ K+ + L+ A +Q +L EI+ A
Sbjct: 408 HAAIERRNEYNLRKLDEEYKERIA-ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEE 466
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
++ L LK+ + + + ++ E LT +L + V L E+ G+L
Sbjct: 467 NYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV--LAEKFGDL----- 519
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL--HILQQKYDEVEDKL 644
D S + +++ +M N E + + +L+ Q +L EL + Q + + K
Sbjct: 520 DPSSAEFFLQE--ERLTQMRNEYERQCR---VLQDQVDELQSELEEYRAQGRVFRLPLKN 574
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ +++++ E + E+ + L+ S E LVIE + KEQ + I L + E
Sbjct: 575 SPSEEVEANSGGIEPEHGLGSEECNPLNMS-IEAELVIEQM---KEQHHRDICCLRLELE 630
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
D K+++Y ++ +D T K + E + + H + +I A++Q + +
Sbjct: 631 D---KVRHY-EKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
Query: 765 ENIESELS-----KYKSRICRLEESIAVMEDR---RYSLERKA---DQLGSYLQEKQKAY 813
+ E + + K +LEE ++++ ++ +E KA S+ +E++
Sbjct: 687 KEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQ 746
Query: 814 SEYTIQED--ELVNRLAVLMDHD--RVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
S +E L L +VEK LE E KEL +K+Q L+E + +
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE---KM 803
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+E ++D + + + ++ L+ LE R E + L Q+++E E
Sbjct: 804 ETECNRRTTQIEAQFQSD-CQKVTERCESALQSLEG---RYRQELKDLQEQQREEKSQWE 859
Query: 930 IEFNTQIESAIRDKKVLNE--KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
E + + +++L E K EK V E ++ E K E+LN V E ++ +
Sbjct: 860 FEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQD 918
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
L D +TQ ++Q + + L++++E + A + ++
Sbjct: 919 LEDLR-NVSETQQSLLSDQILELKSSHIRELREREEVLCQAGASEQLASQRLERLEMEHA 977
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIP 1107
+ + +KL M E + + + + D + E+ + +IKE+++ M
Sbjct: 978 QERQEMMSKLLAM-ENIHKATCETAD--RERAEMSTEISRLQSKIKEMQQATSPLSM--- 1031
Query: 1108 KTEGMIISSTIEPMSDDANNV--DXXXXXXXXXXXXLKVQE-EEEFIQERSVLQEQSAKL 1164
G + E D A ++ L +Q E+ ++E + + ++L
Sbjct: 1032 LQSGCQVIGEEEVEGDGALSLLHQGEQLLEENGDVFLSLQRAHEQAVKENVKMATEISRL 1091
Query: 1165 NTELQECYTKIIQLETLN---TELTGHDVVNQEQINQLKSKLEQLNTENDNLLS-----T 1216
LQ+ ++ L+ TE G+ E Q + ++LS
Sbjct: 1092 QQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDE 1151
Query: 1217 VAELRSSISSAVDQRGFEI--AELWKQHLAQRE-ADFQKTEH-ELRVQLSAFESKYEQLL 1272
V +L S+ +S+V ++ +I +E + ++ E ++ +TE EL+ Q+S + + L
Sbjct: 1152 VRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLC 1211
Query: 1273 DSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+++++ + + + + L+ E + Y DV + + L+ E+ +
Sbjct: 1212 ADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMET 1271
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ L+ E + +++ E + L++ + ++K +
Sbjct: 1272 RYDEALENNKELTAEVFR-LQDELKKMEEVTE-TFLSLEKSYDEVKIENEELNVLVLRLQ 1329
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
++ + V++ L ++ + E + Q N E ++ IE+
Sbjct: 1330 GKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1388
Query: 1453 YEK---ESELAIL-RLKMHENANHYETMQKESEIERV--KLIEELNVKITESVSLNKQVA 1506
E E +L ++K HE A + T+Q E RV ++I E N + + Q
Sbjct: 1389 QENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
LE E K E+ L+ + +V D +++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1484
Score = 48.8 bits (111), Expect = 2e-04
Identities = 104/493 (21%), Positives = 209/493 (42%), Gaps = 51/493 (10%)
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+ LLE + ++K + L++ + L+ S++ ++A +E+ N +L + + +Y+
Sbjct: 370 RHLLERVDQVVREKEKLRSDLDKAEKLKSSMASEVDDHHAAIERRNEYNLRKLDE-EYKE 428
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
++ L++ L++ + +++ E+E EIE E+ IRD+ L+ K +E
Sbjct: 429 RIAALKNELRKEREQILQQAGKQRLELEQ-EIEKAKTEENYIRDRLALSLKENSRLENEL 487
Query: 959 QLEAQ-LQEYKNNIENLNMNVE--------ELNKMNLELIDKHVQKQQTQSPDYTEQ--- 1006
A+ L EY+N L N+E +L+ + E + + Q ++ +Y Q
Sbjct: 488 LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN-EYERQCRV 546
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNA---QVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+++++L + L++ + + N+ +V S + E L NM E
Sbjct: 547 LQDQVDELQSELEEYRAQGRVFRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQI----KELKETKLTFEM---NIPK---TEGMI 1113
+ V +Q+ +QH+ ++ L E +D++ K+L ET ++ + N+ + E
Sbjct: 607 AELVIEQM--KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT 664
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQ---- 1169
+ I + ++ + + EEE Q + L+E+ L +L+
Sbjct: 665 LEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHE 724
Query: 1170 -ECYTKIIQLE-TLNTELTG--HDVVNQEQINQLKSKLEQLNTENDNLL---STVA--EL 1220
E ++ Q + + E G +E++ L +LEQ + E L T+ EL
Sbjct: 725 MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEEL 784
Query: 1221 RSSISSAVD---QRGFEIAEL-----WKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
R + Q G E E Q AQ ++D QK L + E +Y Q L
Sbjct: 785 RKELLEKHQRELQEGREKMETECNRRTTQIEAQFQSDCQKVTERCESALQSLEGRYRQEL 844
Query: 1273 DSVQSSTQEETNK 1285
+Q +EE ++
Sbjct: 845 KDLQEQQREEKSQ 857
Score = 38.7 bits (86), Expect = 0.17
Identities = 62/370 (16%), Positives = 147/370 (39%), Gaps = 36/370 (9%)
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
D V +E+ +L+S L++ ++ S V + ++I + ++ E +K+ +A +
Sbjct: 377 DQVVREK-EKLRSDLDKAEKLKSSMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 435
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLR 1307
+ +K ++ Q + EQ ++ ++ +++ +++++ + L+N+L + E L
Sbjct: 436 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 495
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
+Y ++ N+++ + EK +R E + ++ + +
Sbjct: 496 ----EYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 551
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ E + + +A + +E H L ++
Sbjct: 552 DELQSELEEYRAQGRVFRLPLKNSPSEEVEANSGGIEPEHGLGSEEC------------- 598
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
N +E E IE + + ++ LRL++ + HYE E+ + K
Sbjct: 599 --------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 1488 IEELNVK-ITESVSLNKQVAELNKALEE-----EVAKTNEMQTALENQEIE---IVTLND 1538
E + + E+ +L KQ+++L + E V K + ++E + V L +
Sbjct: 651 QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE 710
Query: 1539 EITNLQNMVR 1548
E T+LQ +R
Sbjct: 711 EKTHLQEKLR 720
>AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein.
Length = 2058
Score = 89.4 bits (212), Expect = 9e-17
Identities = 160/818 (19%), Positives = 358/818 (43%), Gaps = 84/818 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQI 512
QLEH + + + ++ E K QE+L++ L++E + + L +L AE I
Sbjct: 77 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR--AREQLAVELSKAEGVI 134
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
DE + I+ K++ +L+Q N ++ + E ++ EE LS++
Sbjct: 135 DGYADE-KTLFERQIQEKTDIIDRLEQELLCASN--RLQELEAEQQQIQEERELLSRQKE 191
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
++ E G ++ L+ E E L + +L+ E + DL +++
Sbjct: 192 AMKAEAGPVEQQLLQ----------------ETEKLMKEKLEVQCQAEKVRDDLQKQVKA 235
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+ +VE++++ +L+ ++ + + L +Q AL +++ ++ +D+E
Sbjct: 236 LE---IDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH- 288
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKIQTQF 751
+ D+ + +++ + + + + +S + E+ NH +E++ ++
Sbjct: 289 ----------ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 338
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ + +RD+ N E+ K + R+ LE+++ V D +E + G+ ++ K +
Sbjct: 339 LLSKEQLQRDIQERN--EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHFGA-VEAKPE 394
Query: 812 AYSEYTIQ--EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
E +Q D + + + + + +E+ E+E++N+E+Q+ + L + + L
Sbjct: 395 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 454
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDL 928
+++Q + + LA ES TQ + L +I E + I Q +++ L
Sbjct: 455 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 514
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ Q D KV+ EK E + TQ+E + + + N +E+LN++ +E
Sbjct: 515 Q-----QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV-IEK 568
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN--NAQVSYM-SMVSD 1045
+ + + ++ E + L L E +AL Q++ N ++++M +++ +
Sbjct: 569 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 628
Query: 1046 YESKLAQFTTKLENMEEEMQRVSK-QLLDSKQHNEELQILVREQ--------DDQIKELK 1096
K+ Q T +L +++ E + V K Q + N + L +++ +D +K L
Sbjct: 629 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL- 687
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
E + F+ +G II+ + + A +++ + Q E E +Q
Sbjct: 688 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 747
Query: 1153 ER-----SVLQEQSA-----KLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQI--NQL 1199
++ +++E+ A ++ E + Y K Q +T+++E ++ N Q+ ++L
Sbjct: 748 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 807
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
S + L L S V E+ +S+ +++ EIAE
Sbjct: 808 GSDISALTLRISELESQVVEMHTSL--ILEKEQVEIAE 843
Score = 83.4 bits (197), Expect = 6e-15
Identities = 271/1436 (18%), Positives = 577/1436 (40%), Gaps = 143/1436 (9%)
Query: 217 QMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQ 276
Q + ++ I E E ++ +K E+ V L+E KL++ + E+ + K+
Sbjct: 170 QELEAEQQQIQEERELLSRQKEAMK-AEAGPVEQQLLQETEKLMKE-KLEVQCQAEKVRD 227
Query: 277 ELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNC 336
+L++ + IE E+ TE+ + A +L K + L+
Sbjct: 228 DLQKQVKALEIDVEEQ---VSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI 284
Query: 337 QIRQTNKELENKLATMGTESKAVS--SP-SKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
+ ++ + + K V P S+ + + + + K LS E
Sbjct: 285 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 344
Query: 394 LNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQ 453
L +D ++ EI KLE ++ L + L + DT G +L
Sbjct: 345 LQRDIQER--NEEIEKLEFRVRELEQAL------LVSADTFQKVEDRKHFGAVEAKPELS 396
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQEL---NDEIKDVNVKDLIEKLKSAE- 509
LE Q E + + +++ + + EQ ++EL N+E++ ++++ I+K +S
Sbjct: 397 LEVQLQAERDA---IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 453
Query: 510 -EQITQLNDEI-DAANKNMIKVKSNHKLKLKQMQKTIDNFSKV-SDSNKEIVRLTEELHH 566
+++ Q N D K + +K + + + F+++ + EI +L E++
Sbjct: 454 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 513
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDL 626
L Q++ + K + + + D +E+ + M + E + R + I L L
Sbjct: 514 LQQQLKITTDNKVIEEKNELIRD----LETQIECLMSDQECVKRNREEEIEQLNEVIEKL 569
Query: 627 VQELHILQQKYDEVEDKL---ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
QEL + QK L AD + Q D V +E + LE+Q++ + + V++
Sbjct: 570 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE--KLALEQQVETANEEMTFMKNVLK 627
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEE 743
QL + L+ ++E + K+Q+ + ++++ ++ +S +K EL + +
Sbjct: 628 ETNFKMNQLTQELFSLKRERESV-EKIQSIPENSVNVA--IDHLSKDK-PELEVVLTEDA 683
Query: 744 QSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC----RLEESIAVMEDRRYSLERKA 799
++ Q + + I N+E+ L + +S + L + ++D + + +
Sbjct: 684 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 743
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVE-KQLLEIEHENKELQKKNQIL 858
+ L + QK E +L + ++ + + Q + E E +Q NQ+
Sbjct: 744 EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 803
Query: 859 LEENQN----LQISLSDMQQH----YNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
+E + L + +S+++ + +L+ + + ++AE + + +L +L+ L+
Sbjct: 804 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG- 862
Query: 911 THEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKN 969
+E + +KK+ +D+E+ + T++ + + NE E V +A+L YK
Sbjct: 863 -NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT-KAELASYKE 920
Query: 970 NIENLN--MNVEELNKMNLEL----IDKHVQKQQT-----QSPDYTEQYINE-------- 1010
E L + V+E N +L+ + H+ + + + D TE ++
Sbjct: 921 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 980
Query: 1011 -INKLNALLKQKDE--EIIALNQK----INNA--QVSYMSMVSDYESK--LAQFTTKLEN 1059
I ++ Q D +I + NQ + NA Q++ S S E ++QFT K+E
Sbjct: 981 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 1040
Query: 1060 MEE---------EMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKT 1109
M+E E + +S+ ++H +Q+L +E+ +K + + + E +IP+
Sbjct: 1041 MQELHAAEILDMESRHISETETLKREHYVAVQLL-KEECGTLKAVIQCLRSKEGSSIPEL 1099
Query: 1110 EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQ 1169
T E S D+ + D + E + S K+ L+
Sbjct: 1100 AHSDAYQTREICSSDSGS-DWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR 1158
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ + +Q+ +L TE D I Q+ E E ++T++ L+ I+
Sbjct: 1159 AVHNEGMQVLSL-TESPYSDG-EDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQL 1213
Query: 1230 QRGFEIAELWKQHLAQREADFQKTEHELRVQLS-AFESKYEQLLDSVQSS-TQEETNKIV 1287
QR E+ + + H F EL + L F + LL + ++ T T V
Sbjct: 1214 QREAEVYDSSQSH-----ESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAV 1268
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQE--KYAD---VINQIEILRSEIEDEKVAFXXXXXXXX 1342
+ + L+ ++Q++ + E + AD ++++I+ L +++ K+
Sbjct: 1269 GL--LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 1326
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
+++ + +MQ + + ++ + +L++ + A+ K
Sbjct: 1327 PSQELLEYNIQQKQSQMLEMQVE-LSSMKDRATELQEQLSSEKMVVAELKSEL--AQTK- 1382
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
LEL L+ + + ++ + + + + DE + L +K+ +L + E E A L
Sbjct: 1383 LELETTLKAQHKHL-KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 1441
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
E KE +E+L + N Q LN LE++ NE
Sbjct: 1442 --------GRSEERDKEE-------LEDLKFSLESQKQRNLQ---LNLLLEQQKQLLNES 1483
Query: 1523 QTALENQEI--EIVTLNDEITNLQNMVRASSSKIQ-KHVSFASDTKQGRDEQLDNT 1575
Q +E+Q + + ++ NL+ V S K++ + +S D ++ QL ++
Sbjct: 1484 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS 1539
Score = 78.2 bits (184), Expect = 2e-13
Identities = 175/895 (19%), Positives = 369/895 (41%), Gaps = 78/895 (8%)
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYG-TIKDLENDKEDIMNKLQNYIQENMD 719
S L+ ++ L + E + +E+ K+ + +L + + + E + K Q ++E +
Sbjct: 57 SSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESL--KCQEELRERLH 114
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
+ + A ++S+ I+ K T F + +IQE+ I+ +E EL +R+
Sbjct: 115 EESRAREQLAVELSKAEGVIDGYADEK--TLF--ERQIQEKTDIIDRLEQELLCASNRLQ 170
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV--- 836
LE +++ R L R+ + + + ++ + T E + +L V ++V
Sbjct: 171 ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET--EKLMKEKLEVQCQAEKVRDD 228
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
++KQ+ +E + +E Q I LE+ +N + L D++Q AL ++ + E
Sbjct: 229 LQKQVKALEIDVEE-QVSRFIELEQEKNTE--LMDLRQQNQALEKQLEKMRKFLDEQAID 285
Query: 897 QTQLRDL-ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ RD+ + ++++ E Q +V + + I + + Q+ + +++K +K + +
Sbjct: 286 REHERDVFQQEIQKL--EQQLKVVPRFQPISEHQTREVEQLANHLKEK---TDKCSELLL 340
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
QL+ +QE IE L V EL + L D QK + + + E++
Sbjct: 341 SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTF-QKVEDRKHFGAVEAKPELSLEV 399
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
L ++D A+++K +++ E +L QF +LEN EE+Q++ Q
Sbjct: 400 QLQAERD----AIDRKEKE--------ITNLEEQLEQFREELENKNEEVQQLHMQ----- 442
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
L+I +E +++EL++ F+ ++ K G+ I SD + D
Sbjct: 443 -----LEIQKKESTTRLQELEQENKLFKDDMEKL-GLAIKE-----SDAMSTQDQHVLFG 491
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKIIQLET-LNTELTGHDVV 1191
+ + E + + E+ +Q K+ T+ ++E I LET + ++ + V
Sbjct: 492 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 551
Query: 1192 ---NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA-QRE 1247
+E+I QL +E+L E N+ + S+S D ++ + + LA +++
Sbjct: 552 KRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 611
Query: 1248 ADFQKTEHE-LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSL-QNKLQDKEEH 1305
+ E ++ L K QL + S +E ++E++ S+ +N + +H
Sbjct: 612 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE----SVEKIQSIPENSVNVAIDH 667
Query: 1306 LRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQ 1365
L + + V+ + + E + +F L + + Q
Sbjct: 668 LSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 727
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
I + Q + + V + A L Q++L+ + Y K +
Sbjct: 728 CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA--LVSQIQLEAVQEYAKFCQDNQ 785
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERV 1485
T++ E R + + ED E S+++ L L++ E + M +E+
Sbjct: 786 TISS-----EPERTNIQNLNQLRED---ELGSDISALTLRISELESQVVEMHTSLILEK- 836
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
E++ + + K++ EL K LE K E + Q++E++ E+
Sbjct: 837 ---EQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL 888
Score = 58.4 bits (135), Expect = 2e-07
Identities = 93/502 (18%), Positives = 206/502 (41%), Gaps = 36/502 (7%)
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
+N ++ L D ++ K L+ E E + + ++ + L ++L + +++ A
Sbjct: 1198 INTISSLKD---LITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 1254
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI--VQKK------KEIEDLEIEFNTQ 935
RT+L +T L LE ++ E+Q + +QK EI+ L + N +
Sbjct: 1255 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 1314
Query: 936 IESAIRDK---KVLNEKYEKNIEY----VTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ R++ K E E NI+ + +++ +L K+ L + + EL
Sbjct: 1315 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 1374
Query: 989 IDKHVQKQQTQSPDYTEQY--INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+ Q + Q+ + E+ +K K +E+ LN + + Q +
Sbjct: 1375 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 1434
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
E + A+ E +EE++ + L KQ N +L +L+ +Q + E ++ ++ +
Sbjct: 1435 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 1494
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS- 1161
+ + + +G + + S+ + ++Q + Q R L +
Sbjct: 1495 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 1554
Query: 1162 -AKLNTELQECYTKIIQL--ET----LNTELTGHDVVNQEQINQLKSKLEQ-LNTENDNL 1213
+L +L+E +++I++L ET L++ T + Q+++ + EQ NTE
Sbjct: 1555 LKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKK 1614
Query: 1214 LSTVAELRSSISSAVDQRGFEI--AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
+ + + ++++ ++ +L Q L +FQK E E + + Y+ L
Sbjct: 1615 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 1674
Query: 1272 LD-SVQSSTQEETNKIVTMEQV 1292
+ + S T + T V +++
Sbjct: 1675 NEPTTWSLTSDRTRNWVLQQKI 1696
Score = 58.0 bits (134), Expect = 3e-07
Identities = 110/626 (17%), Positives = 254/626 (40%), Gaps = 47/626 (7%)
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+N+I + EE +++ L+ + P+ E +N ++L A +++ E I
Sbjct: 15 RNDINMWSKVTEEGTELSQRLVRSGFAGTEID-PENEELMLNISSRLQAAVEKLLEAISE 73
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVRE 1087
+ ++ +A+V+ ++ + + + T L+ EE +R+ ++ + E+L + + +
Sbjct: 74 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEE----SRAREQLAVELSK 129
Query: 1088 QDDQIKELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ 1145
+ I + K FE I + +I + + S+ ++ L Q
Sbjct: 130 AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 189
Query: 1146 EE----EEFIQERSVLQEQSAKLNTELQ-ECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
+E E E+ +LQE + +L+ +C + ++ + L ++ ++ +EQ+++
Sbjct: 190 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQVKALEIDVEEQVSRFI 248
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
++ NTE +L L + ++ + + ++H +R+ FQ+ +L Q
Sbjct: 249 ELEQEKNTELMDLRQQNQALEKQLEKM--RKFLDEQAIDREH--ERDV-FQQEIQKLEQQ 303
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
L +++ + + ++ N + E+ L KE+ R++QE+ + I ++
Sbjct: 304 LKVVP-RFQPISEHQTREVEQLANHL--KEKTDKCSELLLSKEQLQRDIQERNEE-IEKL 359
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
E E+E + + + E Q+Q E +A +K
Sbjct: 360 EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA-------ERDAIDRKE 412
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
+ + E ++ + +LE K+ E+ Q + I + + + Q+
Sbjct: 413 K------------EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 460
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN-----VKI 1495
++ +E L + A+ H + + +E E+E +L E++ +KI
Sbjct: 461 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 520
Query: 1496 TESVSLNKQVAELNKALEEEV-AKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
T + ++ EL + LE ++ ++ + N+E EI LN+ I LQ + K
Sbjct: 521 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 580
Query: 1555 QKHVSFASDTKQGRDEQLDNTMNKEL 1580
+ S+ QLD + ++L
Sbjct: 581 SMNAHSLSEEADSLKHQLDVVIAEKL 606
Score = 55.2 bits (127), Expect = 2e-06
Identities = 146/750 (19%), Positives = 326/750 (43%), Gaps = 73/750 (9%)
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS--DQVCSEIKSVHLEEQ 667
E R I+ + S K DL+ ++ + Q+ EV D ++ ++ V LEE+
Sbjct: 1192 EERKAYINTISSLK-DLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEER 1248
Query: 668 IDALSASKKEL-ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
L+A + EL AL + L I++ + + M LQ + L +++
Sbjct: 1249 SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSEIQA 1306
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+ A+ + + E++S+ +Q ++ IQ++ + ++ ELS K R L+E ++
Sbjct: 1307 LHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 1365
Query: 787 ----VMEDRRYSLERKADQLGSYLQEKQKAYSE---YTIQEDELVNRLAVLMDHDRVVEK 839
V+ + + L + +L + L+ + K E + ++ + + + +L D +K
Sbjct: 1366 SEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK 1425
Query: 840 QLLE----IEHENKELQKKNQILLEENQNLQISLSDMQQ---HYNALVEKANR-----TD 887
+ E +E E +L + + EE ++L+ SL +Q N L+E+ +
Sbjct: 1426 KSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 1485
Query: 888 LAESESTKYQTQLRDLES-NLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
ES+ Y QL + + NL+ ++ E + + +++ D E E + Q++S+ D
Sbjct: 1486 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS--DGTG 1543
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
+ + + + +L+ QL+E + I L +N E K++ L + ++ Q T
Sbjct: 1544 QSRPPLPSEDLLKELQKQLEEKHSRIVEL-LNETEKYKLD-SLQTRQQMEKDRQVHRKTL 1601
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
Q E N + +++ L K+ + Q + + ++ + + + ++ MQ
Sbjct: 1602 QTEQEAN------TEGQKKMHELQSKVEDLQ----RQLEEKRQQVYKLDLEGQRLQGIMQ 1651
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
KQ L+ ++ E +IL + ++ T+ + +T ++ IE + ++
Sbjct: 1652 EFQKQELEREEKRESRRILYQNLNE--------PTTWSLTSDRTRNWVLQQKIEGETKES 1703
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N E E I+++ LQ ++KL L + ++ +Q ET + E
Sbjct: 1704 NYAKLIEMNGGGTG----CNHELEMIRQK--LQCVASKLQV-LPQKASERLQFETADDE- 1755
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ QE I+++ +L++L + S V+ +S S ++ + AEL H++Q
Sbjct: 1756 --DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTERLLRQNAEL-TGHISQ 1811
Query: 1246 READFQKTEHELRVQLSAFESK---YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+ +++LR + E + Y Q +S++ N +E + + + ++ ++
Sbjct: 1812 ----LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNR 1867
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
E+ LQ+ ++ L++E+ ++ +
Sbjct: 1868 EK--LTLQKSLKRAEAEVYKLKAELRNDSL 1895
Score = 35.1 bits (77), Expect = 2.1
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 13/153 (8%)
Query: 1435 ENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYE-TMQKESEIERVKL-IEELN 1492
+ +++Q VEY+ +E L L +H N + T+++E E E+ + E N
Sbjct: 1276 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 1335
Query: 1493 VKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVR 1548
++ +S L QV EL+ + + E+Q L ++++ + L E+ L+ ++
Sbjct: 1336 IQQKQSQMLEMQV-ELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLK 1390
Query: 1549 ASSSKIQKHVSFASDTKQGRDE--QLDNTMNKE 1579
A +++ +F + K DE L++T+ E
Sbjct: 1391 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 1423
>Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50
protein.
Length = 1318
Score = 89.0 bits (211), Expect = 1e-16
Identities = 191/907 (21%), Positives = 383/907 (42%), Gaps = 83/907 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E + ++ + Q Q +E E+K +K EK +QIT ++ ++K ++K N
Sbjct: 196 ETLRQVRQTQGQKVEEYQMELK--YLKQYKEKACEIRDQITSKEAQL-TSSKEIVKSYEN 252
Query: 533 HKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL------QLHL 585
LK K I+ N SK+ + EI L + + +ELEE+ + QL+
Sbjct: 253 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 312
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ ++ R + + +K+++ E K LL +K +L+ E LQ + D ++ +
Sbjct: 313 LYHNHQRTVR-EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 371
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG---TIKDLEND 702
L I+S+ + ++D + KL +E+ G T L ND
Sbjct: 372 ARDSL--------IQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMND 423
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS---KIQTQFGIDAKIQE 759
+ Q I E D L ++ E SE+L+K +E ++ ++Q G +I E
Sbjct: 424 FAEKETLKQKQIDEIRDKKTGLGRI-IELKSEILSKKQNELKNVKYELQQLEGSSDRILE 482
Query: 760 RDLYIENIESELSKYK--SRICRLEESIAVMEDRRYSLERKADQLGSYLQE--------- 808
D + E ELSK + S + L+ + +++ + L+R +L +++
Sbjct: 483 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 542
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVV-------EKQLLEIEH-ENKELQKKNQILLE 860
+ + ++ +DE + ++ + +KQL + H ++KE+ + L +
Sbjct: 543 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 602
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTLIV 919
N+ L S + H N +E+ L+ E + +D ES+L R+ E +
Sbjct: 603 LNKEL-ASSEQNKNHINNELER-KEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK--S 658
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN-LNMNV 978
K++ + +Q + + D+ N+ + V Q EA+LQE +++++ L +
Sbjct: 659 SKQRAMLAGATAVYSQFITQLTDE---NQSCCPVCQRVFQTEAELQEAISDLQSKLRLAP 715
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYI-----NEINKLNALLKQKDEEIIALNQKIN 1033
++L EL K ++ + Q I EI +L L+ + +I L I
Sbjct: 716 DKLKSTESELKKKEKRRDEMLGLAPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 775
Query: 1034 NAQVSYMSMVSDYESKLAQFT--TKLENMEEEMQRVSKQLLD--SKQHNEELQILVREQD 1089
+ +++ + ES T T +E + E++ V +++ +K +L V +Q
Sbjct: 776 EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTV-QQV 834
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+Q K+ K+ KL T I + + D + K+Q
Sbjct: 835 NQEKQEKQHKL-------DTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-KLQISTN 886
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q R L+EQ+ +L+TE+Q Y +I + + L Q++ +L +K N
Sbjct: 887 -LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 945
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ L+ + E +I + I + ++ Q+E + K + QLS E E
Sbjct: 946 AQDKLNDIKEKVKNIHGYMKDIENHIQDGKDDYMKQKETELNK----VIAQLSECEKHKE 1001
Query: 1270 QLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQE---KYADVINQIEILRS 1325
++ + ++ Q+ +T KI E+ L+ + E L+ ++E ++ + Q+++L+
Sbjct: 1002 KINEDMRLMRQDIDTQKI--QERWLQDNLTLRKRNEELKEVEEEGKQHLKEMGQMQVLQM 1059
Query: 1326 EIEDEKV 1332
+ E +K+
Sbjct: 1060 KSEHQKL 1066
Score = 74.1 bits (174), Expect = 4e-12
Identities = 188/1087 (17%), Positives = 443/1087 (40%), Gaps = 97/1087 (8%)
Query: 61 LENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE------- 113
L + ++ E AT + + + ++ +++ ++ ++ +KQYKE
Sbjct: 172 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVEEYQMELKYLKQYKEKACEIRD 231
Query: 114 --LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETT 171
SK + T + +L ++ H + I + DN + L + K ME
Sbjct: 232 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 291
Query: 172 ILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAE 231
+L+EK+ +++ + ++ D +++ K+ + + E
Sbjct: 292 NSELEEKM---EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQE 348
Query: 232 WKD---EKQRLLKDIESKDVRISSLEEANKLLEAARFEIS-LEHSKLAQ-ELEQXXXXXX 286
+ E+ RL + I + + + L A + E+ E ++ +++
Sbjct: 349 KSELLVEQGRLQLQADRHQEHIRARDSLIQSL-ATQLELDGFERGPFSERQIKNFHKLVR 407
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM-TELTKKIELLEHLNCQIRQTNKEL 345
A Q + E++T +++K EI + T L + IEL + + + K +
Sbjct: 408 ERQEGEAKTANQLMNDFAEKET-LKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 466
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
+ +L + S + ++ LI + + A K S L E ++ +K
Sbjct: 467 KYELQQLEGSSDRILELDQE---LIKAERELSKAEK-NSNVETLKMEVISLQNEKADLDR 522
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
+ KL+ ++ LN + T KD I +++ H + SL
Sbjct: 523 TLRKLDQEMEQLNHHTTTR--------TQMEMLTKDKADKDEQIRKIKSRHSDELT--SL 572
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+ N ++QL+ L+ + K++N +++ +LN E+ ++ +N
Sbjct: 573 LGYFPN----------KKQLEDWLHSKSKEIN---------QTRDRLAKLNKELASSEQN 613
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKV---SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
+ + + K +Q+ D V D ++ RL EE+ S++ A L
Sbjct: 614 KNHINNELERKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYS 673
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF---DLVQELHILQQKYDE 639
+ V +++ + E AE + +AIS L+S+ D ++ +K ++
Sbjct: 674 QFITQLTDENQSCCPVCQRVFQTE--AELQ-EAISDLQSKLRLAPDKLKSTESELKKKEK 730
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL 699
D++ ++ ++ + ++K + E + L +++ + +++ ++E L GTI
Sbjct: 731 RRDEMLGLAPMRQSII--DLKEKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPE 787
Query: 700 ENDKEDIMNK---LQNYIQENMDLTDKLEKMSAE----KISELLAKINHEEQSKIQTQFG 752
E + + ++ + E D+ K+ + +A+ + + ++N E+Q K
Sbjct: 788 EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDT 847
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEE---SIAVMEDRRYSLERKADQLGSYLQEK 809
+ +KI+ I++ + ++ KS L+ I+ RR LE + +L + E
Sbjct: 848 VSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELST---EV 904
Query: 810 QKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH-ENKELQKKNQILLEENQNLQIS 868
Q Y E E V+ L ++ + +++L+ ++ NK Q K + E+ +N+
Sbjct: 905 QSLYREIK-DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGY 963
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ--KKKEIE 926
+ D++ H K + E+E K QL + E + ++I +E L+ Q ++I+
Sbjct: 964 MKDIENHIQD--GKDDYMKQKETELNKVIAQLSECEKHKEKI-NEDMRLMRQDIDTQKIQ 1020
Query: 927 DLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
+ ++ N + + K + E+ +++++ + Q+ Q+ + K+ + L N++ + + +
Sbjct: 1021 ERWLQDNLTLRKRNEELKEVEEEGKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHN 1078
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+ + QK + + ++ + E +A K ++ I+ ++ N + Y
Sbjct: 1079 LALGR--QKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDI------Y 1130
Query: 1047 ESKLAQFTTKLENME-EEMQRVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEM 1104
L Q K +M+ EE+ ++ + L S ++++ I +R D+ + + +
Sbjct: 1131 YKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNY 1190
Query: 1105 NIPKTEG 1111
+ +G
Sbjct: 1191 RVVMLKG 1197
Score = 64.9 bits (151), Expect = 2e-09
Identities = 183/988 (18%), Positives = 400/988 (40%), Gaps = 79/988 (7%)
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK--KELALVIENLKLDKE 690
L+QK+DE+ I L++ + + + +EE L K KE A I + KE
Sbjct: 178 LKQKFDEIFSATRYIKALETLRQVRQTQGQKVEEYQMELKYLKQYKEKACEIRDQITSKE 237
Query: 691 -QLYGT---IKDLENDKEDIMNKLQNYIQENMDLTDKLEK--MSAEKISELLAKINHEEQ 744
QL + +K EN+ + + N+L+ I+ N+ KL+ + + + + K N E +
Sbjct: 238 AQLTSSKEIVKSYENELDPLKNRLKE-IEHNLSKIMKLDNEIKALDSRKKQMEKDNSELE 296
Query: 745 SKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLG 803
K++ F G D ++ DLY + + K + + E + ++ R + K++ L
Sbjct: 297 EKMEKVFQGTDEQLN--DLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLV 354
Query: 804 SY--LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV-----EKQL-----LEIEHENKEL 851
LQ + + E+ D L+ LA ++ D E+Q+ L E + E
Sbjct: 355 EQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEA 414
Query: 852 QKKNQILLE--ENQNL---QIS-LSDMQQHYNALVE-KANRTDLAESESTKYQTQLRDLE 904
+ NQ++ + E + L QI + D + ++E K+ ++E + +L+ LE
Sbjct: 415 KTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLE 474
Query: 905 SNLKRITHEHQTLI--------VQKKKEIEDLEIE-FNTQIESAIRDKKV--LNEKYEKN 953
+ RI Q LI +K +E L++E + Q E A D+ + L+++ E+
Sbjct: 475 GSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL 534
Query: 954 IEYVT---QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
+ T Q+E ++ + E + + L+ K+Q + D+ E
Sbjct: 535 NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE--DWLHSKSKE 592
Query: 1011 INKLNALLKQKDEEIIALNQK---INNAQVSYMSMVSDYESKL------AQFTTKLENME 1061
IN+ L + ++E+ + Q INN +S YE KL F + L+ ++
Sbjct: 593 INQTRDRLAKLNKELASSEQNKNHINNELERKEEQLSSYEDKLFDVCGSQDFESDLDRLK 652
Query: 1062 EEMQRVSKQ-LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI-ISSTIE 1119
EE+++ SKQ + + Q + + D+ + F+ E + + S +
Sbjct: 653 EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEAISDLQSKLR 712
Query: 1120 PMSDDANNVDXXXXXXXXXXXXL----KVQEEEEFIQERSV--LQEQSAKLNTELQECYT 1173
D + + + +++ ++E+ + L+ + +N ++Q
Sbjct: 713 LAPDKLKSTESELKKKEKRRDEMLGLAPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKN 772
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
I + ETL + + + + + + +E+ E ++ +A+ + + R
Sbjct: 773 DIEEQETLLGTIMPEEESAKVCLTDV-TIMERFQMELKDVERKIAQQAAKLQGIDLDRTV 831
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT-MEQV 1292
+ KQ Q + D ++ EL +L + + Q L S + + E +I T +++
Sbjct: 832 QQVNQEKQE-KQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRR 890
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXX 1349
L+ + + +++L + D Q+ L + +E EK
Sbjct: 891 QQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKL 950
Query: 1350 XDLRTENQS---YKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT 1406
D++ + ++ Y + E I + ++ + K++ + + + + L
Sbjct: 951 NDIKEKVKNIHGYMKDIENHIQDGKDDYMKQKETELNKVIAQLSECEKHKEKINEDMRLM 1010
Query: 1407 HQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKM 1466
Q ++ +I ++ + +TL +RN+E + V + E ++ ++++ + ++ K+
Sbjct: 1011 RQ-DIDTQKIQERWLQDNLTLRKRNEELKEVEE---EGKQHLKEMGQMQVLQMKSEHQKL 1066
Query: 1467 HENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTAL 1526
EN ++ + + R K EE + + + Q + + E + +
Sbjct: 1067 EENIDNIK-RNHNLALGRQKGYEEEIIHFKKELR-EPQFRDAEEKYREMMIVMRTTELVN 1124
Query: 1527 ENQEIEIVTLNDEITNLQNMVRASSSKI 1554
++ +I TL+ I +M +KI
Sbjct: 1125 KDLDIYYKTLDQAIMKFHSMKMEEINKI 1152
>AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A
protein.
Length = 1016
Score = 89.0 bits (211), Expect = 1e-16
Identities = 160/818 (19%), Positives = 357/818 (43%), Gaps = 84/818 (10%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQI 512
QLEH + + + ++ E K QE+L++ L++E + + L +L AE I
Sbjct: 224 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR--AREQLAVELSKAEGVI 281
Query: 513 TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA 572
DE + I+ K++ +L+Q N ++ + E ++ EE LS++
Sbjct: 282 DGYADE-KTLFERQIQEKTDIIDRLEQELLCASN--RLQELEAEQQQIQEERELLSRQKE 338
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
++ E G ++ L+ E E L + +L+ E + DL +++
Sbjct: 339 AMKAEAGPVEQQLLQ----------------ETEKLMKEKLEVQCQAEKVRDDLQKQVKA 382
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
L+ +VE++++ +L+ ++ + + L +Q AL +++ ++ +D+E
Sbjct: 383 LE---IDVEEQVSRFIELEQEK---NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH- 435
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQSKIQTQF 751
+ D+ + +++ + + + + +S + E+ NH +E++ ++
Sbjct: 436 ----------ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 485
Query: 752 GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ + +RD+ N E+ K + R+ LE+++ V D +E + G+ ++ K +
Sbjct: 486 LLSKEQLQRDIQERN--EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHFGA-VEAKPE 541
Query: 812 AYSEYTIQ--EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
E +Q D + + + + + +E+ E+E++N+E+Q+ + L + + L
Sbjct: 542 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 601
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDL 928
+++Q + + LA ES TQ + L +I E + I Q +++ L
Sbjct: 602 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 661
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ Q D KV+ EK E + TQ+E + + + N +E+LN++ +E
Sbjct: 662 Q-----QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV-IEK 715
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN--NAQVSYM-SMVSD 1045
+ + + ++ E + L L E +AL Q++ N ++++M +++ +
Sbjct: 716 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 775
Query: 1046 YESKLAQFTTKLENMEEEMQRVSK-QLLDSKQHNEELQILVREQ--------DDQIKELK 1096
K+ Q T +L +++ E + V K Q + N + L +++ +D +K L
Sbjct: 776 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL- 834
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPM----SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
E + F +G II+ + + A +++ + Q E E +Q
Sbjct: 835 ENQTYFRSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 894
Query: 1153 ER-----SVLQEQSA-----KLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQI--NQL 1199
++ +++E+ A ++ E + Y K Q +T+++E ++ N Q+ ++L
Sbjct: 895 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 954
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAE 1237
S + L L S V E+ +S+ +++ EIAE
Sbjct: 955 GSDISALTLRISELESQVVEMHTSL--ILEKEQVEIAE 990
Score = 77.4 bits (182), Expect = 4e-13
Identities = 184/888 (20%), Positives = 370/888 (41%), Gaps = 98/888 (11%)
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYG-TIKDLENDKEDIMNKLQNYIQENMD 719
S L+ ++ L + E + +E+ K+ + +L + + + E + K Q ++E +
Sbjct: 204 SSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESL--KCQEELRERLH 261
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRIC 779
+ + A ++S+ I+ K T F + +IQE+ I+ +E EL +R+
Sbjct: 262 EESRAREQLAVELSKAEGVIDGYADEK--TLF--ERQIQEKTDIIDRLEQELLCASNRLQ 317
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRV--- 836
LE +++ R L R+ + + + ++ + T E + +L V ++V
Sbjct: 318 ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET--EKLMKEKLEVQCQAEKVRDD 375
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKY 896
++KQ+ +E + +E Q I LE+ +N + L D++Q AL ++ + E
Sbjct: 376 LQKQVKALEIDVEE-QVSRFIELEQEKNTE--LMDLRQQNQALEKQLEKMRKFLDEQAID 432
Query: 897 QTQLRDL-ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE 955
+ RD+ + ++++ E Q +V + + I + + Q+ + +++K +K + +
Sbjct: 433 REHERDVFQQEIQKL--EQQLKVVPRFQPISEHQTREVEQLANHLKEK---TDKCSELLL 487
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLN 1015
QL+ +QE IE L V EL + L D QK + + + E++
Sbjct: 488 SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTF-QKVEDRKHFGAVEAKPELSLEV 546
Query: 1016 ALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK 1075
L ++D A+++K +++ E +L QF +LEN EE+Q++ Q
Sbjct: 547 QLQAERD----AIDRKEKE--------ITNLEEQLEQFREELENKNEEVQQLHMQ----- 589
Query: 1076 QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
L+I +E +++EL++ F+ ++ K G+ I SD + D
Sbjct: 590 -----LEIQKKESTTRLQELEQENKLFKDDMEKL-GLAIKE-----SDAMSTQDQHVLFG 638
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ 1195
+ + E + + E+ +Q K+ T+ + K + L T++ + +QE
Sbjct: 639 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL-MSDQEC 697
Query: 1196 INQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
+ + + ++EQLN + L +A + S H EAD K
Sbjct: 698 VKRNREEEIEQLNEVIEKLQQELANIGQKTS-------------MNAHSLSEEADSLK-- 742
Query: 1255 HELRVQLS---AFESKYEQLLDSV--QSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
H+L V ++ A E + E + + + +ETN M Q+T L+ + E + +
Sbjct: 743 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN--FKMNQLTQELFSLKRERESVEKI 800
Query: 1310 QEKYADVIN-QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
Q + +N I+ L + + +V + +T +S+++ + SI+
Sbjct: 801 QSIPENSVNVAIDHLSKDKPELEVVL--------TEDALKSLENQTYFRSFEENGKGSII 852
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
N+ QL+ + ++ D + + T L+ K + + E
Sbjct: 853 NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAAL 912
Query: 1429 QRNDEFENVRQQLVEYEKRIED-LTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
+ E V+ EY K +D T E E + +N N + S+I + L
Sbjct: 913 VSQIQLEAVQ----EYAKFCQDNQTISSEPERTNI-----QNLNQLREDELGSDISALTL 963
Query: 1488 -IEELNVKITE---SVSLNKQVAEL-NKALEEEVAKTNEMQTALENQE 1530
I EL ++ E S+ L K+ E+ K + E+ K E+Q LE E
Sbjct: 964 RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 1011
Score = 58.0 bits (134), Expect = 3e-07
Identities = 110/626 (17%), Positives = 254/626 (40%), Gaps = 47/626 (7%)
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+N+I + EE +++ L+ + P+ E +N ++L A +++ E I
Sbjct: 162 RNDINMWSKVTEEGTELSQRLVRSGFAGTEID-PENEELMLNISSRLQAAVEKLLEAISE 220
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVRE 1087
+ ++ +A+V+ ++ + + + T L+ EE +R+ ++ + E+L + + +
Sbjct: 221 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEE----SRAREQLAVELSK 276
Query: 1088 QDDQIKELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ 1145
+ I + K FE I + +I + + S+ ++ L Q
Sbjct: 277 AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 336
Query: 1146 EE----EEFIQERSVLQEQSAKLNTELQ-ECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
+E E E+ +LQE + +L+ +C + ++ + L ++ ++ +EQ+++
Sbjct: 337 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQVKALEIDVEEQVSRFI 395
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQ 1260
++ NTE +L L + ++ + + ++H +R+ FQ+ +L Q
Sbjct: 396 ELEQEKNTELMDLRQQNQALEKQLEKM--RKFLDEQAIDREH--ERDV-FQQEIQKLEQQ 450
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
L +++ + + ++ N + E+ L KE+ R++QE+ + I ++
Sbjct: 451 LKVVP-RFQPISEHQTREVEQLANHL--KEKTDKCSELLLSKEQLQRDIQERNEE-IEKL 506
Query: 1321 EILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKS 1380
E E+E + + + E Q+Q E +A +K
Sbjct: 507 EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA-------ERDAIDRKE 559
Query: 1381 SXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQ 1440
+ + E ++ + +LE K+ E+ Q + I + + + Q+
Sbjct: 560 K------------EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 607
Query: 1441 LVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELN-----VKI 1495
++ +E L + A+ H + + +E E+E +L E++ +KI
Sbjct: 608 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 667
Query: 1496 TESVSLNKQVAELNKALEEEV-AKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
T + ++ EL + LE ++ ++ + N+E EI LN+ I LQ + K
Sbjct: 668 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 727
Query: 1555 QKHVSFASDTKQGRDEQLDNTMNKEL 1580
+ S+ QLD + ++L
Sbjct: 728 SMNAHSLSEEADSLKHQLDVVIAEKL 753
Score = 52.4 bits (120), Expect = 1e-05
Identities = 113/661 (17%), Positives = 267/661 (40%), Gaps = 62/661 (9%)
Query: 170 TTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAME 229
T ++DL+++ ++ +E K + +QQ+ K+ F +
Sbjct: 403 TELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPIS 461
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
E ++L ++ K + S L + + L+ E + E KL + +
Sbjct: 462 EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSA 521
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
+ + + E K E+ + L+ A + +K + + +L Q+ Q +ELENK
Sbjct: 522 DTFQKVEDRKHFGAVEAKPELSLEVQLQ-AERDAIDRKEKEITNLEEQLEQFREELENKN 580
Query: 350 ATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI-A 408
+ + K+ + + N K +L D +++ +
Sbjct: 581 EEVQQLHMQLEIQKKESTTRLQELEQENKL--FKDDMEKLGLAIKESDAMSTQDQHVLFG 638
Query: 409 KLEMVIQS--LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
K +IQ + D ++++ ++ K+ LI L+ + + M +
Sbjct: 639 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 698
Query: 467 HVGTNTEDVNEIAKVQEQLKQELND--EIKDVNVKDLIEKLKSAEEQIT-------QLND 517
E++ ++ +V E+L+QEL + + +N L E+ S + Q+ L
Sbjct: 699 K-RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 757
Query: 518 EIDAANKNMIKVKSNHK---LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAEL 574
+++ AN+ M +K+ K K+ Q+ + + + + +S ++I + E + ++ + L
Sbjct: 758 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPE--NSVNVAIDHL 815
Query: 575 EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQ 634
++K L++ L + D+ + +E+ Y + E LL+ + ++L L
Sbjct: 816 SKDKPELEVVLTE-DALKSLENQTYFRSFEENGKGSIINLETRLLQLESTVSAKDLE-LT 873
Query: 635 QKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG 694
Q Y +++D + + Q +++ + +I V+L++ ++ +K A ++ ++L+ Q Y
Sbjct: 874 QCYKQIKD-MQEQGQFETEMLQKKI--VNLQKIVE-----EKVAAALVSQIQLEAVQEYA 925
Query: 695 TIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID 754
+ Q+N ++ + E+ + + +++L + + G D
Sbjct: 926 -----------------KFCQDNQTISSEPERTNIQNLNQLR-----------EDELGSD 957
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS 814
I L I +ES++ + + + +E + + E E+K +L L+ +K
Sbjct: 958 --ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 1015
Query: 815 E 815
E
Sbjct: 1016 E 1016
>AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein.
Length = 1047
Score = 89.0 bits (211), Expect = 1e-16
Identities = 147/762 (19%), Positives = 324/762 (42%), Gaps = 53/762 (6%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+NT+ ++ K Q++L Q+ N+E + L LK ND+ N++
Sbjct: 276 SNTQATPDLLKGQQELTQQTNEETAK---QILYNYLKEGSTD----NDDATKRKVNLVFE 328
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
K LK + N ++ +S E+ L E+ L+ +VAEL+ + LQL + +
Sbjct: 329 KIQ-TLKSRAAGSAQGN-NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQ 383
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA-DIS 648
+ I+ + + +E L SQ + V+E LQQ+ +E E +L ++
Sbjct: 384 N---IKEERERMRANLEEL-----------RSQHNEKVEENSTLQQRLEESEGELRKNLE 429
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGT-IKDLENDKEDIM 707
+L ++ E + + D LS EL ++ K +++ G I++L K+D+
Sbjct: 430 ELFQVKMEREQHQTEIRDLQDQLSEMHDEL----DSAKRSEDREKGALIEELLQAKQDLQ 485
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+ L +E DL K E+ L +++ +Q + + DA++Q +E
Sbjct: 486 DLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 544
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ SR E+ A E R L+ + ++L +E ++ ++ Q ++L
Sbjct: 545 TKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE 604
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A + + E ++ ++E +K+ + + + L+ L Q + + ++ +
Sbjct: 605 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 664
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
E ++ + QLR L++ ++ I + +KE+ D+ T S + + L+
Sbjct: 665 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT---STLELQNQLD 721
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
E EKN + +++ QL+E E + ++ + L+++ ++ Q ++
Sbjct: 722 EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQ----DEA 776
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + L LK + E+ A + ++ +V E K++Q +LE +
Sbjct: 777 LTKRQLLEQTLKDLEYELEAKSHLKDDRS----RLVKQMEDKVSQLEMELEEERNNSDLL 832
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S+++ S++ E+++ + ++ ++L+ K++ E + II S
Sbjct: 833 SERISRSREQMEQVRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 892
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
V L+ +E ++R+ LQ + +L +++E ++Q++ + LT
Sbjct: 893 VVQMEARIAELEDRLESEE-----RDRANLQLSNRRLERKVKEL---VMQVDDEHLSLTD 944
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ +K ++E+ E D L S+ +L+ + +D
Sbjct: 945 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 986
Score = 88.2 bits (209), Expect = 2e-16
Identities = 131/683 (19%), Positives = 298/683 (43%), Gaps = 47/683 (6%)
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLK 686
++++++ +K ++ + A +Q ++Q C+ V L EQ L+ EL ++
Sbjct: 321 RKVNLVFEKIQTLKSRAAGSAQ-GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV 379
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQ 744
+++ + + + + E++ ++ ++EN L +LE+ E K E L ++ E +
Sbjct: 380 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 439
Query: 745 SKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ--- 801
QT+ D + Q +++ E ++ S+ + + +EE + +D + L K +Q
Sbjct: 440 QH-QTEIR-DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 497
Query: 802 ------------------LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+ S+ QE K +Y + L + + V+ +
Sbjct: 498 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 557
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESEST--KYQTQ 899
E + + + ++L EEN+ LQ ++++ L + + D A+++ T KY+ +
Sbjct: 558 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 617
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R LE L E + + ++ +LE + +++K L+EK ++ E Q
Sbjct: 618 IRQLEEALVHARKEEKEAVSARRALENELEAA-QGNLSQTTQEQKQLSEKLKEESEQKEQ 676
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELID---KHVQKQQTQSPDYTEQYINEINKLNA 1016
L E +N +L +E+L K ++++ + Q Q +Y E+ E+ ++
Sbjct: 677 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 736
Query: 1017 LLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
LK+K E+ K+ + + DY+ + TK + +E+ ++ + + L+
Sbjct: 737 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LE 795
Query: 1074 SKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN-VDXX 1131
+K H ++ LV++ +D++ +L E +L E N IS + E M N +
Sbjct: 796 AKSHLKDDRSRLVKQMEDKVSQL-EMELEEERNNSDLLSERISRSREQMEQVRNELLQER 854
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE--LQECYTKIIQLETLNTELTGHD 1189
+ ++ + + ++ R + E S + + E + + +I +LE E D
Sbjct: 855 AARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERD 913
Query: 1190 VVNQEQIN-QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N + N +L+ K+++L + D+ ++ + + +S + ++ E ++ + + E+
Sbjct: 914 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA-EEEIDRLES 972
Query: 1249 DFQKTEHELRVQLSAFESKYEQL 1271
+K + EL Q+ E QL
Sbjct: 973 SKKKLQRELEEQMDMNEHLQGQL 995
Score = 77.8 bits (183), Expect = 3e-13
Identities = 130/703 (18%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+++Q +++ +I +L+E D A+K+++ LV E ++ K + G+ +
Sbjct: 290 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG------ 343
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
N+ N E DL ++ K++ E +A++ + Q +++ Q I +ER+
Sbjct: 344 --NNQACNSTSEVKDLLEQKSKLTIE-----VAELQRQLQLEVKNQQNIK---EERERMR 393
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
N+E S++ ++ +E+ L + ++L E+++ +E +D+L
Sbjct: 394 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 453
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
HD E++ + ++ L+EE + L D+ L+ K
Sbjct: 454 EM------HD--------ELDSAKRSEDREKGALIEELLQAKQDLQDL------LIAKEE 493
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDK 943
+ DL K + +L L+ LK H + K KE D E++ +E A ++
Sbjct: 494 QEDLLR----KRERELTALKGALKEEVSSHDQEM-DKLKEQYDAELQALRESVEEATKNV 548
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSP 1001
+VL + + + E +++ + E L EEL + L+ + ++ + ++
Sbjct: 549 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 608
Query: 1002 DYTEQYINEINKLNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++Y EI +L L +++++E ++ + + N + +S + Q + KL+
Sbjct: 609 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 668
Query: 1059 N---MEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+E+++R+ ++ + + H + ++ L +E D ++ + + L + + + +
Sbjct: 669 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE--- 725
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ E + +K+Q+E ++E L++ + L +
Sbjct: 726 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE--LRDYQRAQDEALTKRQLL 783
Query: 1175 IIQLETLNTELTGHDVVNQEQ---INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR 1231
L+ L EL + ++ + Q++ K+ QL E + + L IS + +Q
Sbjct: 784 EQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 843
Query: 1232 GFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME- 1290
EL ++ A+++ + K L Q +S+ L S +SS + +V ME
Sbjct: 844 EQVRNELLQERAARQDLECDKIS--LERQNKDLKSRIIHLEGSYRSSKE---GLVVQMEA 898
Query: 1291 QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
++ L+++L+ +E NLQ + +++ L +++DE ++
Sbjct: 899 RIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 941
Score = 75.8 bits (178), Expect = 1e-12
Identities = 130/629 (20%), Positives = 283/629 (44%), Gaps = 75/629 (11%)
Query: 449 IAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ-ELNDEIKDVNVKDLIEKLKS 507
+ +L+ +H + +E S + E E+ K E+L Q ++ E ++DL
Sbjct: 396 LEELRSQHNEKVEENSTLQQRLE-ESEGELRKNLEELFQVKMEREQHQTEIRDL------ 448
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVR-----LTE 562
++Q+++++DE+D+A ++ + K +L Q ++ + + + ++++R LT
Sbjct: 449 -QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 507
Query: 563 ELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
L ++V+ ++E L + + + + R + K + + + + T + + E
Sbjct: 508 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 567
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALV 681
+ L +E LQ + +E+E ++A + + D E K+ +E + ++L
Sbjct: 568 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKA---KETLKKYEGEIRQLEEA 624
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK---------- 731
+ + + ++++ + LEN+ E L QE L++KL++ S +K
Sbjct: 625 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 684
Query: 732 ------ISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKY----KSRICR 780
+ + + K+ E ++ ++Q + D Y E EL++ K +
Sbjct: 685 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 744
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS-----EYTIQ--EDELVNRLAVLMDH 833
E+S + + ++L Y + + +A + E T++ E EL + + D
Sbjct: 745 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 804
Query: 834 DRVV---EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLA 889
R+V E ++ ++E E +E ++ N LL E + S M+Q N L+ E+A R DL
Sbjct: 805 SRLVKQMEDKVSQLEMELEE-ERNNSDLLSER--ISRSREQMEQVRNELLQERAARQDL- 860
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQT----LIVQKKKEIEDLEIEFNTQIESAIRDK-- 943
E + + Q +DL+S + + +++ L+VQ + I +LE ++ES RD+
Sbjct: 861 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE----DRLESEERDRAN 916
Query: 944 -KVLNEKYEKNI-EYVTQLEAQ---LQEYKN----NIENLNMNVEELNKM--NLELIDKH 992
++ N + E+ + E V Q++ + L + K+ ++ + VEE + LE K
Sbjct: 917 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 976
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+Q++ + D E ++N + L+ K
Sbjct: 977 LQRELEEQMDMNEHLQGQLNSMKKDLRLK 1005
Score = 71.7 bits (168), Expect = 2e-11
Identities = 132/676 (19%), Positives = 275/676 (40%), Gaps = 64/676 (9%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E + LL+ + ++ L+ +L + I E ++ LE+
Sbjct: 353 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 412
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L ++ E E + +EE +++ T+ + L Q+ + + EL++ +
Sbjct: 413 LQQRLEESEGELRKNLEELFQVKMEREQHQTE----IRDLQDQLSEMHDELDSAKRSEDR 468
Query: 355 ESKAVSSPSKKGSP-----LISRKSGRNTASKMKSPWSQLSS----ETLNQDTDK-KINK 404
E A+ + LI+++ + K + + L E + D + K+ +
Sbjct: 469 EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE 528
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
A+L+ + +S+ + + E + S +T G + + LQ E+++
Sbjct: 529 QYDAELQALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEKLQ---- 580
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
G + E +A++Q Q++ DE K E LK E +I QL + + A K
Sbjct: 581 ----GRSEELERRVAQLQRQIEDLKGDEAKAK------ETLKKYEGEIRQLEEALVHARK 630
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
+ S + +++ N S+ + K++ +E +++ L+ E N + H
Sbjct: 631 EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 690
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAIS-----LLESQKFDLVQELHILQQKYDE 639
L G+ IE + K+M ++ + T + E + +L + L++K E
Sbjct: 691 L-----GKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLE 744
Query: 640 VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTI 696
E ++Q + E + + D ++ L +++L+ + K L
Sbjct: 745 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 804
Query: 697 KDLENDKEDIMNKLQNYIQE---NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG- 752
L ED +++L+ ++E N DL + S E++ ++ ++ E ++ +
Sbjct: 805 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQVRNELLQERAARQDLECDK 864
Query: 753 IDAKIQERDLYIENIESELSKYKSR---ICRLEESIAVMEDRRYSLERKADQL---GSYL 806
I + Q +DL I E S S+ + ++E IA +EDR S ER L L
Sbjct: 865 ISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL 924
Query: 807 QEKQKA--------YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ K K + T Q+D+L RL + E+++ +E K+LQ++ +
Sbjct: 925 ERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 984
Query: 859 LEENQNLQISLSDMQQ 874
++ N++LQ L+ M++
Sbjct: 985 MDMNEHLQGQLNSMKK 1000
Score = 70.9 bits (166), Expect = 3e-11
Identities = 133/692 (19%), Positives = 282/692 (40%), Gaps = 57/692 (8%)
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH 992
N S K +L +K + IE V +L+ QLQ N +N+ E + EL +H
Sbjct: 345 NQACNSTSEVKDLLEQKSKLTIE-VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 403
Query: 993 VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQ 1052
+K + S T Q + + L++ EE+ + + Q + +
Sbjct: 404 NEKVEENS---TLQ--QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 458
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
+ + + E + ++LL +KQ ++L I EQ+D +++ +E +LT K E
Sbjct: 459 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK-RERELTALKGALKEEVS 517
Query: 1113 IISSTIEPMSD--DA------NNVDXXXXXXXXXXXXLKVQEEEEFIQERSV--LQEQSA 1162
++ + + DA +V+ E+++ E V LQE++
Sbjct: 518 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 577
Query: 1163 KLNTELQECYTKIIQLETLNTELTGHDVVNQE-------QINQLKSKLEQLNTENDNLLS 1215
KL +E ++ QL+ +L G + +E +I QL+ L E +S
Sbjct: 578 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS 637
Query: 1216 TVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
L + + +A Q ++ L+++ + + + +LR + E++ L ++
Sbjct: 638 ARRALENELEAA--QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 695
Query: 1276 QSSTQEETNKIVTMEQVTS--LQNKLQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+ Q+E IV + ++ LQN+L + KE++ R L E Q ++ +E EK
Sbjct: 696 E-KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM------QRQLKEKTLEAEKS 748
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ E + Y++ Q++++ LK
Sbjct: 749 RLTAMKMQDEMRL------MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKD 802
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
R + ++ + QLE++ E + + +++ ++ E VR +L++ +DL
Sbjct: 803 DR-SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQVRNELLQERAARQDLE 861
Query: 1453 YEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL- 1508
+K E + L+ ++ Y + ++ ++ I EL ++ ES ++ +L
Sbjct: 862 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL-ESEERDRANLQLS 920
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEIT----NLQNMVRASSSKIQKHVSFASDT 1564
N+ LE K E+ ++++ + + D+++ ++ V + +I + S
Sbjct: 921 NRRLER---KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL 977
Query: 1565 KQGRDEQLDNTMNKELLDAVPRAELDLAMYML 1596
++ +EQ+D MN+ L + + DL + L
Sbjct: 978 QRELEEQMD--MNEHLQGQLNSMKKDLRLKKL 1007
Score = 44.8 bits (101), Expect = 0.003
Identities = 88/487 (18%), Positives = 197/487 (40%), Gaps = 34/487 (6%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-VNQEQINQLKSKL 1203
Q + ++ + L +Q+ + T Q Y + + T N + T V + E+I LKS+
Sbjct: 279 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 337
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHE-LRVQL 1261
N+ ++ +E++ + + E+AEL +Q L + K E E +R L
Sbjct: 338 AGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 396
Query: 1262 SAFESKYEQLLD---SVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
S++ + ++ ++Q +E ++ +E++ ++ + + + +R+LQ++ +++
Sbjct: 397 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 456
Query: 1318 NQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN------I 1370
++++ RSE ++ E+ K+ +E + L +
Sbjct: 457 DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 516
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+ + ++ K V +A V L + + + Q E + L Q
Sbjct: 517 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD--QAGTEMRVKLLQE 574
Query: 1431 NDE-----FENVRQQLVEYEKRIEDLTYEKESELAILRL------KMHENANHYETMQKE 1479
+E E + +++ + +++IEDL ++ L+ ++ E H +KE
Sbjct: 575 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 634
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
+ R L EL ++ +L++ L+EE + +++ E E L
Sbjct: 635 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 694
Query: 1540 ITNLQ----NMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYM 1595
I LQ ++V AS + + + + K+ +L M ++L + AE M
Sbjct: 695 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE-MQRQLKEKTLEAEKSRLTAM 753
Query: 1596 LHQRDVR 1602
Q ++R
Sbjct: 754 KMQDEMR 760
>AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit
SP-R210 alphaS protein.
Length = 1581
Score = 88.2 bits (209), Expect = 2e-16
Identities = 151/767 (19%), Positives = 334/767 (43%), Gaps = 74/767 (9%)
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEK 578
I KN+ K K ++ T+ +V S ++I EE+ L K+ + E+E+
Sbjct: 760 IRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKER 819
Query: 579 GNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD 638
L+L+ D R+ S++ ++ + N E+ + + +++ +E+ LQ +YD
Sbjct: 820 NELRLN-SDRLESRI--SELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYD 876
Query: 639 E-------VEDKLADISQLQSDQVCSEIKS--------VHLEEQIDALSASKKELALVIE 683
+E ++ + +++ ++ E+ + E + + +KK L E
Sbjct: 877 ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 936
Query: 684 N-LKLD---KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+ L+++ K QL + DL+ D E+ LQ ++ LT +L+ + +
Sbjct: 937 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR-- 994
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESE-LSKYKSRICRLEESIAVMEDRRYSLERK 798
NHE + K Q +F + + E ++ E L + K + L E+ ++ + LE K
Sbjct: 995 NHELEKK-QRRFDSELSQAHEEAQREKLQREKLQREKDML--LAEAFSL----KQQLEEK 1047
Query: 799 ADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ + Q+ + + + QE + LA + R +E ++ + E E E
Sbjct: 1048 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1107
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
Q+L + L++ + M+Q ++ E +R + E Q +L+ +E L+ +E +
Sbjct: 1108 QMLEQAKLRLEMEMERMRQTHSK--EMESRDEEVEEARQSCQKKLKQMEVQLEE-EYEDK 1164
Query: 916 TLIVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN---- 970
++++K+E+E + Q+ +K L + ++ + + L KN+
Sbjct: 1165 QKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSK 1224
Query: 971 --IENLNMNVEE-----------LNKMNLELIDKHVQ-----KQQTQSPDYTEQYINEIN 1012
I L +EE M +E+ D H+Q K +T + + E N
Sbjct: 1225 REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN 1284
Query: 1013 KLNALLKQKDEEIIAL--NQKINNAQVSY-MSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ L++ E++ L K AQ S ++ ++D +++L + + + ++E++Q +
Sbjct: 1285 EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1344
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMI--ISSTIEPMSDDAN 1126
Q+ +Q + + LV Q+ +I+EL ET+L FE + + E + + +E ++++ +
Sbjct: 1345 QVEFLEQSMVD-KSLVSRQEAKIREL-ETRLEFERTQVKRLESLASRLKENMEKLTEERD 1402
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
L+ ++ + +E L + A+ + + E + LE N L
Sbjct: 1403 QRIAAENREKEQNKRLQ-RQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1461
Query: 1187 GHDVVNQEQINQLKSKL--EQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ ++I L++ + E + EN++L+++ + S + S ++ R
Sbjct: 1462 ADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGD--SDVDSELEDR 1506
Score = 87.8 bits (208), Expect = 3e-16
Identities = 142/722 (19%), Positives = 300/722 (41%), Gaps = 64/722 (8%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E ++ I +L + E R L +D+L S + E SE T E
Sbjct: 795 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELT-DERNTGESA 850
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
+ L+D + + L E E KELQ + L ++ + +++ + + + A + D
Sbjct: 851 SQLLDAETA---ERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDD 907
Query: 888 LAESE-STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
A E KY+ +R+++ KR+ E + K E+E + Q+E + D +
Sbjct: 908 DAGGEWRLKYERAVREVDFTKKRLQQEFED-----KLEVEQ---QNKRQLERRLGDLQAD 959
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+E+ ++ ++ QL+ + Q +++ +++E N EL K + S + E
Sbjct: 960 SEESQRALQ---QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1016
Query: 1007 YINEINKLNALLKQKD---EEIIALNQKINNAQVS---YMSMVSDYESKLAQFTTKLENM 1060
++ + L ++KD E +L Q++ + + V E++L +++
Sbjct: 1017 QREKLQR-EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1075
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
E + +V KQL D + ++ + + EQ I+ L++ KL EM + E M + + E
Sbjct: 1076 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEM---ERMRQTHSKEM 1132
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ---SAKLNTELQECYTKIIQ 1177
S D V+ ++VQ EEE+ ++ VL+E+ KL T + + +
Sbjct: 1133 ESRD-EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE 1191
Query: 1178 LET-----------------LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
E L + + ++ +I QLK++LE E++ + +
Sbjct: 1192 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE----ESEFTCAAAVKA 1247
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQRE--ADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
R ++ ++ +I ++ K A E + Q+ ++E++ +L + +L+ +++
Sbjct: 1248 RKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAA 1307
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+ + + Q+ LQ +L++ + + LQEK + +Q+E L + D+ +
Sbjct: 1308 VAQASRDLA---QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEA 1364
Query: 1339 XXXXXXXXXXXXDLRTEN-QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
+ + +S ++++ + EE Q + ++ D
Sbjct: 1365 KIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRD 1424
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES 1457
+ ++ EL K++E +K HE + L ++++ L KRI DL E
Sbjct: 1425 TKEEMGELAR----KEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED 1480
Query: 1458 EL 1459
E+
Sbjct: 1481 EM 1482
Score = 80.6 bits (190), Expect = 4e-14
Identities = 140/719 (19%), Positives = 299/719 (41%), Gaps = 59/719 (8%)
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLAESESTKY 896
E+Q+ + E ++L+ K + +E L+++ ++ + L E + + ES S
Sbjct: 795 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 854
Query: 897 QTQLRD---LESNLKRITHEHQTLIVQKK-KEIEDLEIEF--NTQIESAIRDKKVLNE-- 948
+ + E +K + ++ L Q + E+E +E +I + D E
Sbjct: 855 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 914
Query: 949 -KYEKNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
KYE+ + V + +LQ E+++ +E VE+ NK LE +Q +S +Q
Sbjct: 915 LKYERAVREVDFTKKRLQQEFEDKLE-----VEQQNKRQLERRLGDLQADSEESQRALQQ 969
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ +L A L+ D ++ Q++ N ++ E K +F ++L EE QR
Sbjct: 970 LKKKCQRLTAELQ--DTKLHLEGQQVRNHEL---------EKKQRRFDSELSQAHEEAQR 1018
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
Q ++ + L Q++E F + E + + + D+A+
Sbjct: 1019 EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1078
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERS----VLQEQSAKLNTELQEC-YTKIIQLETL 1181
KV+++EE + E++ +L++ +L E++ T ++E+
Sbjct: 1079 ---LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1135
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR---SSISSAVDQRGFEIAEL 1238
+ E+ Q+++ Q++ +LE+ + +L EL +++S V++R FE +
Sbjct: 1136 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1195
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYE--QLLDSVQSS-----TQEETNKIVTMEQ 1291
++ L + +A + L ++ SK E QL + ++ S + K + +E
Sbjct: 1196 LRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE- 1254
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L ++ D + L+E+ + + + +++ +E+++ D
Sbjct: 1255 IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD 1314
Query: 1352 LRTENQSYKQMQEQSILNIN-EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
L N Q++E + +E Q +S V+ EAK+ EL +LE
Sbjct: 1315 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1374
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ +++ ++ L + ++ R Q + E R EKE + R
Sbjct: 1375 FERTQV-KRLESLASRLKENMEKLTEERDQRIAAENR------EKEQNKRLQRQLRDTKE 1427
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
E +KE+E R K E++++ E+ + + Q A+L A + + ++Q A+E++
Sbjct: 1428 EMGELARKEAEASRKKHELEMDLESLEAANQSLQ-ADLKLAFK----RIGDLQAAIEDE 1481
Score = 78.6 bits (185), Expect = 2e-13
Identities = 142/726 (19%), Positives = 297/726 (40%), Gaps = 67/726 (9%)
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
F V+ L +Q +++ +K +I QL+S +E + L D L + EL +
Sbjct: 782 FTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELT 841
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSAEKISELLAKINHE 742
+ + E + D E + K +Q D L ++E M E + L +
Sbjct: 842 DERNTGESA-SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA--- 897
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQ 801
++I + D E L E E+ K R+ + E+ + V + + LER+
Sbjct: 898 --AEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGD 955
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L + +E Q+A + + L L H + + E+E + + + EE
Sbjct: 956 LQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1015
Query: 862 NQNLQISLSDMQQHYNALVEKA----NRTDLAESESTKYQTQLRDLESNLKRITHEH--- 914
Q ++ +Q+ + L+ +A + + + + + ++ LE+ L+ I+ +
Sbjct: 1016 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1075
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + + KK++ DLE + Q E + + + ++E Q + +E+
Sbjct: 1076 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1135
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ VEE + QK+ Q E+ + K+ ++ + ++ L+ ++N
Sbjct: 1136 DEEVEEAR--------QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1187
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV--REQDDQI 1092
D+ES+ + + ++++R L D++ + L+ + + Q+
Sbjct: 1188 ---------RDFESE--------KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1230
Query: 1093 K-ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
K +L+E++ T + + M + IE + + D ++Q E+ I
Sbjct: 1231 KNQLEESEFTCAAAVKARKAMEVE--IEDLHLQID--DIAKAKTALEEQLSRLQREKNEI 1286
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
Q R L+E +N +++ + Q D+ QIN L+++LE+ N E
Sbjct: 1287 QNR--LEEDQEDMNELMKKHKAAVAQ--------ASRDLA---QINDLQAQLEEANKEKQ 1333
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
L + L+S + ++Q + + + +Q RE + + E E R Q+ ES +L
Sbjct: 1334 ELQEKLQALQSQV-EFLEQSMVDKSLVSRQEAKIRELE-TRLEFE-RTQVKRLESLASRL 1390
Query: 1272 LDSVQSSTQEETNKIVT----MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
++++ T+E +I EQ LQ +L+D +E + L K A+ + L ++
Sbjct: 1391 KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL 1450
Query: 1328 EDEKVA 1333
E + A
Sbjct: 1451 ESLEAA 1456
Score = 49.6 bits (113), Expect = 9e-05
Identities = 105/547 (19%), Positives = 221/547 (40%), Gaps = 58/547 (10%)
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ +EE+Q L + + KE E +L N + E I T E ++D+ N +
Sbjct: 799 RNKDEEIQQLRSKLEKAEKERNELRL----NSDRLESRISELTSE-LTDERNTGESASQL 853
Query: 1135 XXXXXXX-LKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L+ ++E + +Q + L++Q + E+ E ++I+ +N E+ D
Sbjct: 854 LDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEA--RLIRAAEINGEVDDDDAGG 911
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ ++ K E+ E D T L+ + E+ + K+ L +R D Q
Sbjct: 912 EWRL-----KYERAVREVD---FTKKRLQQEFEDKL-----EVEQQNKRQLERRLGDLQA 958
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
E + L + K ++L +Q +T + +QV + ++L+ K+ + +
Sbjct: 959 DSEESQRALQQLKKKCQRLTAELQ-----DTKLHLEGQQVRN--HELEKKQRRFDSELSQ 1011
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINE 1372
+ + ++ R +++ EK D+ Q + E + +I+
Sbjct: 1012 AHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSL-EAELQDISS 1070
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAE------AKVLELTHQLELK-DSEIYQKTHEYTI 1425
+ ++ + S +V D E A +++ Q +L+ + E+ + ++
Sbjct: 1071 QESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSK 1130
Query: 1426 TLTQRNDEFENVRQQL--------VEYEKRIED----LTYEKESELAILRLKMHENANHY 1473
+ R++E E RQ V+ E+ ED L ++E E + L N +
Sbjct: 1131 EMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDF 1190
Query: 1474 ETMQK-ESEIERVK-LIEELNVKITE---SVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E+ ++ +++R K L+ + + + S +++A+L LEE A +
Sbjct: 1191 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKA 1250
Query: 1529 QEIEIVTLN---DEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVP 1585
E+EI L+ D+I + + S++Q+ + + + E ++ M K AV
Sbjct: 1251 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKA-AVA 1309
Query: 1586 RAELDLA 1592
+A DLA
Sbjct: 1310 QASRDLA 1316
Score = 46.0 bits (104), Expect = 0.001
Identities = 92/457 (20%), Positives = 196/457 (42%), Gaps = 47/457 (10%)
Query: 307 KTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLAT--------MGTESKA 358
+ E+++ S E + L K + L L +++ +EL+ + T + E +
Sbjct: 1062 EAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEM 1121
Query: 359 VSSPSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ SR A + + Q+ + + DK+ E +LE + +L
Sbjct: 1122 ERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATL 1181
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS---LIHVGTNTED 474
+ D V++ SEK D AQL L+H ++ PS + + E+
Sbjct: 1182 S-DQVNRRDFESEKRLRKDLKRTKALLAD---AQLMLDHLKN-SAPSKREIAQLKNQLEE 1236
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVK-DLIEKLKSA-EEQITQLNDE-------IDAANKN 525
+ ++ + EI+D++++ D I K K+A EEQ+++L E ++ ++
Sbjct: 1237 SEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQED 1296
Query: 526 MIKVKSNHKLKLKQMQKTI----DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
M ++ HK + Q + + D +++ ++NKE L E+L L +V LE+
Sbjct: 1297 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---- 1352
Query: 582 QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE 641
+VD + + S K+ E+E E + LES L + + L ++ D+
Sbjct: 1353 ---MVD----KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQ-R 1404
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + Q+ ++ +++ +E++ L+ + E + L++D E L + L+
Sbjct: 1405 IAAENREKEQNKRLQRQLRDT--KEEMGELARKEAEASRKKHELEMDLESLEAANQSLQA 1462
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAEKISEL 735
D + + LQ I++ M+ + + +++E S++
Sbjct: 1463 DLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDV 1499
>AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein.
Length = 1302
Score = 88.2 bits (209), Expect = 2e-16
Identities = 151/765 (19%), Positives = 326/765 (42%), Gaps = 59/765 (7%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKV 529
+NT+ ++ K Q++L Q+ N+E + L LK ND+ N++
Sbjct: 531 SNTQATPDLLKGQQELTQQTNEETAK---QILYNYLKEGSTD----NDDATKRKVNLVFE 583
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD 589
K LK + N ++ +S E+ L E+ L+ +VAEL+ + LQL + +
Sbjct: 584 KIQ-TLKSRAAGSAQGN-NQACNSTSEVKDLLEQKSKLTIEVAELQRQ---LQLEVKNQQ 638
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISLL----ESQKFDLVQELHILQQKYDEVEDKLA 645
+ + + + E+ + +++ S L E + +L + L L Q E E
Sbjct: 639 NIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQT 698
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASK-KELALVIENLKLDKEQLYGTIKDLENDKE 704
+I LQ DQ+ SE + +++D+ S+ +E +IE L K+ L + E +E
Sbjct: 699 EIRDLQ-DQL-SE-----MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEG-RE 750
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
D++ K + +E L L++ + E+ K+ + +++Q + ++E +
Sbjct: 751 DLLRKRE---RELTALKGALKEEVSSHDQEM-DKLKEQYDAELQA---LRESVEEATKNV 803
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
E + S + + E + ++++ L+ ++++L + + Q+ + E +
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
L R +E+ L+ E KE + L E + Q +LS Q L EK
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLK 923
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
E ++ + QLR L++ ++ I + +KE+ D+ T S + +
Sbjct: 924 -------EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT---STLELQN 973
Query: 945 VLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT 1004
L+E EKN + +++ QL+E E + ++ + L+++ ++ Q
Sbjct: 974 QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-GMRLMEEELRDYQRAQ---- 1028
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
++ + + L LK + E+ A + ++ +V E+K++Q +LE
Sbjct: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLKDDRS----RLVKQMEAKVSQLEMELEEERNNS 1084
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDD 1124
+S+++ S++ E+L+ + ++ ++L+ K++ E + II S
Sbjct: 1085 DLLSERISRSREQMEQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIHLEGSYRSSK 1144
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTE 1184
V L+ +E ++R+ LQ + +L +++E ++Q++ +
Sbjct: 1145 EGLVVQMEARIAELEDRLESEE-----RDRANLQLSNRRLERKVKEL---VMQVDDEHLS 1196
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
LT ++ +K ++E+ E D L S+ +L+ + +D
Sbjct: 1197 LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 1241
Score = 84.6 bits (200), Expect = 3e-15
Identities = 130/683 (19%), Positives = 299/683 (43%), Gaps = 47/683 (6%)
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH-LEEQIDALSASKKELALVIENLK 686
++++++ +K ++ + A +Q ++Q C+ V L EQ L+ EL ++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQ-GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEV 634
Query: 687 LDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQ 744
+++ + + + + E++ ++ ++EN L +LE+ E K E L ++ E +
Sbjct: 635 KNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 745 SKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE---------SIAVMEDRRYSL 795
QT+ D + Q +++ E ++ S+ + + +EE + + ++ R L
Sbjct: 695 QH-QTEIR-DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEGREDL 752
Query: 796 ERK------------ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
RK +++ S+ QE K +Y + L + + V+ +
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESEST--KYQTQ 899
E + + + ++L EEN+ LQ ++++ L + + D A+++ T KY+ +
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
+R LE L E + + ++ +LE + +++K L+EK ++ E Q
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELE-GAQGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELID---KHVQKQQTQSPDYTEQYINEINKLNA 1016
L E +N +L +E+L K ++++ + Q Q +Y E+ E+ ++
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 1017 LLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
LK+K E+ K+ + + DY+ + TK + +E+ ++ + + L+
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE-LE 1050
Query: 1074 SKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN-VDXX 1131
+K H ++ LV++ + ++ +L E +L E N IS + E M N +
Sbjct: 1051 AKSHLKDDRSRLVKQMEAKVSQL-EMELEEERNNSDLLSERISRSREQMEQLRNGLLQER 1109
Query: 1132 XXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE--LQECYTKIIQLETLNTELTGHD 1189
+ ++ + + ++ R + E S + + E + + +I +LE E D
Sbjct: 1110 AARQDLECGKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-RLESEERD 1168
Query: 1190 VVNQEQIN-QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
N + N +L+ K+++L + D+ ++ + + +S + ++ E ++ + + E+
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEA-EEEIDRLES 1227
Query: 1249 DFQKTEHELRVQLSAFESKYEQL 1271
+K + EL Q+ E QL
Sbjct: 1228 SKKKLQRELEEQMDMNEHLQGQL 1250
Score = 73.7 bits (173), Expect = 5e-12
Identities = 131/704 (18%), Positives = 302/704 (42%), Gaps = 68/704 (9%)
Query: 646 DISQLQSDQVCSEIKSVHLEE-QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+++Q +++ +I +L+E D A+K+++ LV E ++ K + G+ +
Sbjct: 545 ELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG------ 598
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
N+ N E DL ++ K++ E +A++ + Q +++ Q I +ER+
Sbjct: 599 --NNQACNSTSEVKDLLEQKSKLTIE-----VAELQRQLQLEVKNQQNIK---EERERMR 648
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
N+E S++ ++ +E+ L + ++L E+++ +E +D+L
Sbjct: 649 ANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLS 708
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
HD E++ + ++ L+EE + L D+ L+ K
Sbjct: 709 EM------HD--------ELDSAKRSEDREKGALIEELLQAKQDLQDL------LIAKEG 748
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE-FNTQIESAIRDK 943
R DL K + +L L+ LK H + K KE D E++ +E A ++
Sbjct: 749 REDLLR----KRERELTALKGALKEEVSSHDQEM-DKLKEQYDAELQALRESVEEATKNV 803
Query: 944 KVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSP 1001
+VL + + + E +++ + E L EEL + L+ + ++ + ++
Sbjct: 804 EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863
Query: 1002 DYTEQYINEINKLNALL---KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+ ++Y EI +L L +++++E ++ + + N +S + Q + KL+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLK 923
Query: 1059 N---MEEEMQRVSKQLLDSKQH-NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMII 1114
+E+++R+ ++ + + H + ++ L +E D ++ + + L + + + +
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
Query: 1115 SSTIE---PMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQEC 1171
E + + + +++ EEE +R+ + A +L E
Sbjct: 984 RELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRA---QDEALTKRQLLEQ 1040
Query: 1172 YTKIIQLETLNTELTGHDVVNQEQ-INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ 1230
K ++ E E H ++ + + Q+++K+ QL E + + L IS + +Q
Sbjct: 1041 TLKDLEYEL---EAKSHLKDDRSRLVKQMEAKVSQLEMELEEERNNSDLLSERISRSREQ 1097
Query: 1231 RGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME 1290
L ++ A+++ + K L Q +S+ L S +SS + +V ME
Sbjct: 1098 MEQLRNGLLQERAARQDLECGKIS--LERQNKDLKSRIIHLEGSYRSSKE---GLVVQME 1152
Query: 1291 -QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
++ L+++L+ +E NLQ + +++ L +++DE ++
Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLS 1196
Score = 72.1 bits (169), Expect = 2e-11
Identities = 131/672 (19%), Positives = 269/672 (40%), Gaps = 56/672 (8%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E + LL+ + ++ L+ +L + I E ++ LE+
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L ++ E E + +EE +++ T+ +L + L+ + + ++ G
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPW-----SQLSSETLNQDTDK-KINKNEIA 408
+ + + L+ K GR + + L E + D + K+ + A
Sbjct: 728 LIEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 409 KLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
+L+ + +S+ + + E + S +T G + + LQ E+++
Sbjct: 788 ELQALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEKLQ-------- 835
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIK 528
G + E +A++Q Q++ DE K E LK E +I QL + + A K +
Sbjct: 836 GRSEELERRVAQLQRQIEDLKGDEAKAK------ETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 529 VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDY 588
S + +++ N S+ + K++ +E +++ L+ E N + HL
Sbjct: 890 AVSARRALENELEGAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHL--- 946
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAIS-----LLESQKFDLVQELHILQQKYDEVEDK 643
G+ IE + K+M ++ + T + E + +L + L++K E E
Sbjct: 947 --GKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 644 LADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTIKDLE 700
++Q E + + D ++ L +++L+ + K L L
Sbjct: 1004 RLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV 1063
Query: 701 NDKEDIMNKLQNYIQE---NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG-IDAK 756
E +++L+ ++E N DL + S E++ +L + E ++ + G I +
Sbjct: 1064 KQMEAKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNGLLQERAARQDLECGKISLE 1123
Query: 757 IQERDLYIENIESELSKYKSR---ICRLEESIAVMEDRRYSLERKADQL---GSYLQEKQ 810
Q +DL I E S S+ + ++E IA +EDR S ER L L+ K
Sbjct: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKV 1183
Query: 811 KA--------YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
K + T Q+D+L RL + E+++ +E K+LQ++ + ++ N
Sbjct: 1184 KELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMN 1243
Query: 863 QNLQISLSDMQQ 874
++LQ L+ M++
Sbjct: 1244 EHLQGQLNSMKK 1255
Score = 54.4 bits (125), Expect = 3e-06
Identities = 123/611 (20%), Positives = 257/611 (42%), Gaps = 54/611 (8%)
Query: 154 KDNALSVLQVKMKIME--TTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+ N + QVKM+ + T I DLQ++++E +++ ++
Sbjct: 680 RKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDL 739
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEA-NKLLEAARFEISLE 270
+D ++ E E K L +++ S D + L+E + L+A R + E
Sbjct: 740 QDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE-E 798
Query: 271 HSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
+K + L + ++ EE +++ + + +L ++IE
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGT----EMRVKLLQEENEKLQGRSEELERRVAQLQRQIED 854
Query: 331 LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLS 390
L+ + ++T K+ E ++ + E V + ++ + +R++ N + SQ +
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQL--EEALVHARKEEKEAVSARRALENELEGAQGNLSQTT 912
Query: 391 ------SETLNQDTDKKIN----KNEIAK----LEMVIQSLNKDLVDKEYVISEKDTXXX 436
SE L +++++K KNE+ L I+ L K++ D
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ 972
Query: 437 XXXXXXXGKDTL-IAQLQLE-HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIK 494
K+ +A++Q + ++ +E +D + ++E+L+ + +
Sbjct: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRL--MEEELRDYQRAQDE 1030
Query: 495 DVNVKDLIEK-LKSAEEQI---TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS-K 549
+ + L+E+ LK E ++ + L D+ K M S +++L++ + D S +
Sbjct: 1031 ALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEAKVSQLEMELEEERNNSDLLSER 1090
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYD-SGRMIESD-VYKKMIE-ME 606
+S S +++ +L L L ++ A + E G + L + D R+I + Y+ E +
Sbjct: 1091 ISRSREQMEQLRNGL--LQERAARQDLECGKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148
Query: 607 NLAETRLKAIS-LLESQKFD---LVQELHILQQKYDE----VEDKLADISQLQSDQVCSE 658
E R+ + LES++ D L L++K E V+D+ ++ Q DQ+
Sbjct: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD-QKDQLSLR 1207
Query: 659 IKSV-----HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
+K++ EE+ID L +SKK+L +E E L G + ++ D + KL +
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR--LKKLPSK 1265
Query: 714 IQENMDLTDKL 724
+ ++MD D L
Sbjct: 1266 VLDDMDDDDDL 1276
Score = 41.5 bits (93), Expect = 0.024
Identities = 80/471 (16%), Positives = 191/471 (40%), Gaps = 36/471 (7%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV-VNQEQINQLKSKL 1203
Q + ++ + L +Q+ + T Q Y + + T N + T V + E+I LKS+
Sbjct: 534 QATPDLLKGQQELTQQTNE-ETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHE-LRVQL 1261
N+ ++ +E++ + + E+AEL +Q L + K E E +R L
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANL 651
Query: 1262 SAFESKYEQLLD---SVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVI 1317
S++ + ++ ++Q +E ++ +E++ ++ + + + +R+LQ++ +++
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH 711
Query: 1318 NQIEIL-RSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILN------I 1370
++++ RSE ++ E+ K+ +E + L +
Sbjct: 712 DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEV 771
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+ + ++ K V +A V L + + + Q E + L Q
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD--QAGTEMRVKLLQE 829
Query: 1431 NDE-----FENVRQQLVEYEKRIEDLTYEKESELAILRL------KMHENANHYETMQKE 1479
+E E + +++ + +++IEDL ++ L+ ++ E H +KE
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE------- 1532
+ R L EL ++ +L++ L+EE + +++ E E
Sbjct: 890 AVSARRALENELEGAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 1533 IVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDA 1583
I L E+ ++ R S+ ++Q + + + ++ + ++ L+A
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEA 1000
>AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein.
Length = 4547
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1521 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1576
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1577 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1730
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1731 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1786
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1787 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1840
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1895
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1956 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2074 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2188
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2247
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2300
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2421 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1756
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1937 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2284 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2342 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2400 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2508
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2509 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2561
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2562 AEEGVRRKQEELQQLEQQR 2580
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1323 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1426
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1427 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1484
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1485 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1533
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1534 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1593 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1650 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1825
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1826 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1945 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 2000
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2058
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2059 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2116
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2349
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2350 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2400
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2401 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2457
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1971
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2032 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2089
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2090 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2148 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2264
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2323
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2501
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2558
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2659
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1310 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1426 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1544
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1658
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1839 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1891
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1948
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 2003
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 2004 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2120
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2121 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2176 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
>AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein.
Length = 4551
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1525 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1580
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1581 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1734
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1735 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1790
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1791 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1844
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1899
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1960 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2078 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2192
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2251
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2252 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2304
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2364
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2425 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2483
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1760
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1941 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2288 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2345
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2346 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2404 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2459
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2512
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2513 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2565
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2566 AEEGVRRKQEELQQLEQQR 2584
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1327 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1377
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1430
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1431 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1488
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1489 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1537
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1538 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1597 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1654 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1771
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1829
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1830 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1949 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 2004
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2062
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2063 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2120
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2353
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2354 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2404
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2405 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2461
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1975
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2035
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2036 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2093
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2094 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2152 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2268
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2327
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2448 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2505
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2562
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2622
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2623 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2663
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1313
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1314 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1430 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1488
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1489 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1548
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1549 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1608
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1662
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1842
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1843 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1895
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1952
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 2007
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 2008 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2124
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2125 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2179
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2180 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219
>AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein.
Length = 4547
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1521 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1576
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1577 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1730
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1731 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1786
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1787 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1840
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1895
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1956 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2074 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2188
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2247
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2300
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2421 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1756
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1937 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2284 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2342 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2400 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2508
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2509 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2561
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2562 AEEGVRRKQEELQQLEQQR 2580
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1323 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1426
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1427 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1484
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1485 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1533
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1534 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1593 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1650 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1825
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1826 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1945 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 2000
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2058
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2059 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2116
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2349
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2350 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2400
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2401 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2457
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1971
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2032 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2089
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2090 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2148 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2264
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2323
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2501
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2558
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2659
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1310 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1426 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1544
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1658
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1839 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1891
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1948
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 2003
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 2004 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2120
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2121 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2176 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
>AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein.
Length = 4515
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1489 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1544
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1545 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1698
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1699 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1754
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1755 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1808
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1863
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1924 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2042 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2156
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2215
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2216 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2268
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2328
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2389 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2447
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1724
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1905 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2252 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2309
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2310 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2368 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2423
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2476
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2477 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2529
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2530 AEEGVRRKQEELQQLEQQR 2548
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1291 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1341
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1394
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1395 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1452
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1453 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1501
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1502 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1561 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1618 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1735
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1793
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1794 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1913 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 1968
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2026
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2027 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2084
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2317
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2318 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2368
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2369 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2425
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1939
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 1999
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2000 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2057
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2058 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2116 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2232
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2291
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2412 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2469
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2526
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2586
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2587 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2627
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1277
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1278 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1394 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1452
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1453 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1512
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1513 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1572
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1626
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1806
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1807 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1859
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1916
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 1971
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 1972 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2088
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2089 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2143
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2144 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183
>AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein.
Length = 4684
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1658 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1713
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1714 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1867
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1868 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1923
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1924 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1977
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 2032
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 2093 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2211 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2325
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2384
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2385 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2437
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2438 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2497
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2558 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2616
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1893
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 2074 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2421 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2479 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2537 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2592
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2645
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2646 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2698
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2699 AEEGVRRKQEELQQLEQQR 2717
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1460 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1510
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1563
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1564 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1621
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1622 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1670
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1671 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1730 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1787 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1904
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1962
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1963 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 2082 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 2137
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2195
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2196 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2253
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2486
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2487 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2537
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2538 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2594
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 2108
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2168
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2169 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2226
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2227 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2285 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2401
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2460
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2638
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2695
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2755
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2756 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2796
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1391 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1446
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1447 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1563 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1621
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1622 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1681
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1682 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1741
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1795
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1975
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1976 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 2028
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 2085
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 2140
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 2141 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2257
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2258 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2312
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2313 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352
>AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein.
Length = 4525
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1499 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1554
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1555 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1708
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1709 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1764
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1765 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1818
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1873
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1934 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2052 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2166
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2225
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2278
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2279 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2338
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2399 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2457
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1734
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1915 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2262 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2320 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2378 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2433
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2434 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2486
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2487 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2539
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2540 AEEGVRRKQEELQQLEQQR 2558
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1301 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1351
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1404
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1405 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1462
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1463 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1511
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1512 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1571 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1628 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1745
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1803
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1804 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1923 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 1978
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2036
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2037 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2094
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2327
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2328 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2378
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2379 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2435
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1949
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2009
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2010 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2067
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2068 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2126 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2242
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2301
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2422 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2479
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2536
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2637
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1232 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1287
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1288 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1404 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1462
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1463 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1522
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1523 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1582
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1636
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1817 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1869
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1926
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 1981
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 1982 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2098
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2099 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2153
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2154 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
>AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein.
Length = 4533
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1507 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1562
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1563 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1716
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1717 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1772
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1773 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1826
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1881
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1942 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2060 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2174
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2233
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2234 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2286
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2287 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2346
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2407 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2465
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1742
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1923 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2089
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2270 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2327
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2328 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2386 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2441
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2442 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2494
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2495 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2547
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2548 AEEGVRRKQEELQQLEQQR 2566
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1309 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1359
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1412
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1413 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1470
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1471 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1519
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1520 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1579 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1636 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1694 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1753
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1811
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1812 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1931 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 1986
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2044
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2045 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2102
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2335
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2336 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2386
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2387 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2443
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2471
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1957
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1958 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2017
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2018 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2075
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2076 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2134 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2250
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2309
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2430 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2487
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2544
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2604
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2605 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2645
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1240 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1295
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1296 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1412 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1470
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1471 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1530
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1531 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1590
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1644
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1765 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1824
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1825 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1877
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1934
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 1989
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 1990 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2106
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2107 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2161
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2162 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201
>AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein.
Length = 4574
Score = 88.2 bits (209), Expect = 2e-16
Identities = 216/1120 (19%), Positives = 461/1120 (41%), Gaps = 94/1120 (8%)
Query: 226 IAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXX 285
+ EAE EKQR L+ +E ++R+ + EEA + L A E ++A E Q
Sbjct: 1548 VKAEAEAAREKQRALQALE--ELRLQA-EEAERRLRQAEVE-RARQVQVALETAQRSAEA 1603
Query: 286 XXXXXXXXXLAKQSIEPSCEEKT-EIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
QS S EKT ++E E + +L ++ E + + +E
Sbjct: 1604 EL----------QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653
Query: 345 LENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK 404
E +L ++ + + +KS ++ + ++ + + ++ + +
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 405 NEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS 464
E+A+ E+ Q + ++ + +E++ + +L+ E +Q +
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQE----------------LIRLRAETEQGEQQRQ 1757
Query: 465 LIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
L+ + A Q +QEL E+ V + +E L +++ + + + +K
Sbjct: 1758 LLE--EELARLQREAAAATQKRQELEAELAKVRAE--MEVLLASKARAEEESRSTSEKSK 1813
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ ++ + +++ + +++ K +L EE +++ AE E +L
Sbjct: 1814 QRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAE-KLA 1867
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + E+++ K E EN RL + ++ E Q K D +E++L
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL----EEQAAQHKAD-IEERL 1922
Query: 645 ADI-----SQLQSDQVCSE---IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTI 696
A + S+L+ + E + +EE+I AL AS ++ A L+L+ ++
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982
Query: 697 KDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA-EKISELLA---KINHEEQSKIQTQFG 752
+D KE +L+ Q + ++ + A E++ + LA + + ++ ++
Sbjct: 1983 EDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR--RYSLERKADQLGSYLQEKQ 810
+ AK++E E E E ++ + E++ +++++K +L LQ++Q
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRV-VEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
+ E E R A + RV E++ + + +E ++ Q E+ Q +
Sbjct: 2101 SVLDQLR-GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+ ++ ++A R AE + + Q Q D E K QTL ++K ++E
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEME-KHKKFAEQTL--RQKAQVEQEL 2215
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
Q+E K +L+E+ ++ T+ Q + + + ++ + +EEL+K+ I
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-I 2274
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + D T++++ E + +KQ EE L+ + + + + ++ E
Sbjct: 2275 EAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLS--VAAQEAARLRQLA--EED 2327
Query: 1050 LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI-PK 1108
LAQ E M +E + ++ K E LQ +Q + L+E K + +
Sbjct: 2328 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 1109 TEGMIISSTIEPMSDDANNVDX-XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLN-T 1166
T+G + E + + + + EE+ + R +E KL+ T
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 1167 EL--QECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
EL QE T + LE + + + HD +E I +L+ + E+L E L E+++
Sbjct: 2448 ELATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2506
Query: 1224 ISSAVDQRGFEIAELW---KQHLAQREADFQKTEHELRVQLSAFESKYEQLLD----SVQ 1276
+ Q + + + K L QRE ++ + +L +K +QL + Q
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQD----KEEHLRNLQEK 1312
QE + +ME+ Q++ ++ K+E L+ L+++
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606
Score = 75.4 bits (177), Expect = 2e-12
Identities = 168/919 (18%), Positives = 367/919 (39%), Gaps = 71/919 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKD-EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLE 270
E T QQ ++ I + AE + E+QR L + E ++ L+ R E+ E
Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAE 1783
Query: 271 HSKLAQELEQXXXXXXXX---XXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKK 327
+K+ E+E +KQ +E E+ E+ + A E ++
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843
Query: 328 IELLEHLNCQIR-QTNKELENKLATMGTESKA-----VSSPSKKGSPLISRKSGRNTASK 381
+L E + R + + L KLA +G ++ ++ K+ R+ + A +
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 382 MKSPWSQLSSETLN-QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXX 440
+ Q + + ++ ++ K ++LE + L + V E
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
Query: 441 XXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQEL--NDEIKD 495
GK A+L+LE L + +N ED E A+++ +++L +E +
Sbjct: 1964 AAAGK----AELELE---------LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 496 VNVKDLIEKLKSAEEQIT-QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSN 554
++ ++K +AEE+ Q ++ + KV+ +L+ + Q++ ++
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 555 KEIVRLTEELHHLS--QKVAELEE----EKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
++ ++ E+ H + QK EL++ E+ L + ++ R + + ++ E
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130
Query: 609 AETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQI 668
A + + E K ++ Q E + Q + + +E ++ ++
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE-NMDLTDKLEKM 727
DA K+ A K EQ T++ + + N L +Q + T+ +
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAK---IQERDLYIENIESELSKYKS---RICRL 781
S + ++ EE SK++ + + + ++++D ++ E K K RL
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
Query: 782 EESIAVMEDRRYSLERKADQLGSY-LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
S+A E R + D L EK +QE + A L+ + + ++
Sbjct: 2311 --SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
E+KE + Q L EE Q Q +L +Q + +A R L +E ++ Q +
Sbjct: 2369 QARRLQEDKE--QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426
Query: 901 RDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQL 960
+ ++ E I +K E E T +++ ++ + E+ E + +L
Sbjct: 2427 EEDAQRFRKQAEE----IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2482
Query: 961 EAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ 1020
E + ++ + + L + EE+ + E + Q+TQ+ + +++E + L +
Sbjct: 2483 EREKEKLQQEAKLLQLKSEEMQTVQQEQL-----LQETQA--LQQSFLSEKDSLLQRERF 2535
Query: 1021 KDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++E L Q + +V+ + + + + Q ME+E QR+ + ++++ E
Sbjct: 2536 IEQEKAKLEQLFQD-EVAKAQQLREEQQRQQQ------QMEQERQRLVASMEEARRRQHE 2588
Query: 1081 LQILVREQDDQIKELKETK 1099
+ VR + +++++L++ +
Sbjct: 2589 AEEGVRRKQEELQQLEQQR 2607
Score = 74.5 bits (175), Expect = 3e-12
Identities = 240/1288 (18%), Positives = 521/1288 (40%), Gaps = 97/1288 (7%)
Query: 326 KKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSP 385
+K+E + Q K+ E +L T + + V+SP+KK +S +++
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 386 WSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
+S+L+ TL K I++ + ++E ++ + ++ E++ +
Sbjct: 1350 YSELT--TLTSQYIKFISET-LRRME------EEERLAEQQRAEERERLAEVEAALEKQR 1400
Query: 446 DTLIAQLQLEHQQHMEGPSL-IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
A Q + Q E L + E A +Q K+ + +E++ +
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR------- 1453
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+S+E +I + +AA ++ ++++ ++ Q++ T + ++ + +R E
Sbjct: 1454 -QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-ERQRGGAEGELQALRARAEE 1511
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
++ A+ E E+ Q V +S R K+ E+E + + +A + E Q+
Sbjct: 1512 AEAQKRQAQEEAERLRRQ---VQDESQR-------KRQAEVELASRVKAEAEAAREKQR- 1560
Query: 625 DLVQELHILQQKYDEVEDKL--ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+Q L L+ + +E E +L A++ + + QV E E ++ + AS E +
Sbjct: 1561 -ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
E L +E + + L + E + + + +LE+ + L ++ E
Sbjct: 1620 ER-SLQEEHV--AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEE-SIAVMEDRRYSLERKADQ 801
E ++ ++ +A+ Q+ + E K + + R E + +E +R E A Q
Sbjct: 1677 EVAQQKSLAQAEAEKQKEE--AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734
Query: 802 LGSYLQE--KQKAYSEYTIQEDELV-NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
+ QE + +A +E Q+ +L+ LA L ++ E+E E +++ + ++L
Sbjct: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1794
Query: 859 LEENQNL-QISLSDMQQHYNALVEKANR-TDLAE--------SESTKYQTQLRDLESNLK 908
L + S S ++ L +A R +LAE +E K Q QL E +
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL--AEEDAA 1852
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIE----YVTQLEAQL 964
R E + ++ +K I + T+ E A+++K+ NE+ + E +LE Q
Sbjct: 1853 RQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
++K +IE + + + LE V+ Q E+ + K E
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971
Query: 1025 IIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
+ L + +NA+ + S E + A+ +L EE +R +++ + EE
Sbjct: 1972 ELELGRIRSNAEDTLRSK-EQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEE--EA 2027
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
R++ ++E++ K E E S + A V
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL--AQEAAQKRLQAEEKAHAFAV 2085
Query: 1145 QEEEEFIQERSVLQEQSA--KLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
Q++E+ +Q+ ++ QEQS +L E + + E + ++ Q+ + + +
Sbjct: 2086 QQKEQELQQ-TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-R 2143
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE-ADFQKTEH-ELRVQ 1260
L+Q E + + +Q A+ + L Q++ AD + +H + Q
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
+++ EQ L +++ +E + K + E++ L+ + + ++E+ V
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI-LNI-NEEN 1374
+ ++ L++ IE E A L+ E + KQ+ E++ L++ +E
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRF------LQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 1375 AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR-NDE 1433
A+L++ + ++ + + ++ +L+ ++E+ Q+ E +R ++
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQED 2376
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
E + QQL E E + T E E + +L+M A + + +E+ R + E
Sbjct: 2377 KEQMAQQLAE-ETQGFQRTLEAERQ---RQLEMSAEAERLKL--RVAEMSRAQARAE--- 2427
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ KQ E+ + L T E T ++ EI+ + + L+ + A +
Sbjct: 2428 --EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELER 2484
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELL 1581
++ + + Q + E++ ++LL
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLL 2512
Score = 64.5 bits (150), Expect = 3e-09
Identities = 140/761 (18%), Positives = 322/761 (42%), Gaps = 58/761 (7%)
Query: 212 EDTKQQMTKMQENFIAMEAEW------KDEKQRLLKDIESK-DVRISSLEEANKLLEAAR 264
EDT +Q +++E +A++A + K E + L I S + + S E+A LEAAR
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE--LEAAR 1998
Query: 265 F-EISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTE 323
+++ E + +E E+ K ++E K ++EE L E
Sbjct: 1999 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2058
Query: 324 LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMK 383
++++L + Q R +E + A E + + ++ S ++ + G A++
Sbjct: 2059 SARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAARRA 2116
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
+ + + + + ++ ++ + E + QS + + + +
Sbjct: 2117 A--EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 444 GKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKD 500
+ Q L +Q + H + + + A+V+++L + +L + N+ D
Sbjct: 2175 RR-AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 501 L-IEKLKS----AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+++LK+ A Q +Q+ +E+ + M ++ S K +++ + + K ++ +
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEEL-SKLKARIEAENRALILRDK-DNTQR 2291
Query: 556 EIVRLTEELHHLSQKVAELE---EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAET 611
+ E++ ++++ A L +E L QL D R + + K+ ++ A T
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-T 2350
Query: 612 RLKAISLLESQKFDLVQE-LHILQQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQID 669
RLKA + L Q+ +L QE LQ+ +++ +LA+ +Q Q + + + + +
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLEND--KEDIMNKLQNYIQENMDLTDKLEKM 727
L E++ + D ++ +++ + ++ + + + + +++ +
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQE-RDLYIENIESELSKYKSRICRLEESIA 786
AE++ E +A++ E++ Q + K +E + + E + E + L E +
Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF--LSEKDS 2528
Query: 787 VMEDRRYSLERKA--DQL-------GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVV 837
+++ R+ + KA +QL L+E+Q+ + QE + RL M+ R
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ---RLVASMEEARRR 2585
Query: 838 EKQLLE-IEHENKELQKKNQ-------ILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
+ + E + + +ELQ+ Q +L EENQ L+ L +++ + A + + +
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2645
Query: 890 ESESTKYQTQLRD-LESNLKRITHEHQTLIVQKKKEIEDLE 929
+ +TK RD L+ EH +++K + L+
Sbjct: 2646 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2686
Score = 60.1 bits (139), Expect = 6e-08
Identities = 169/1002 (16%), Positives = 385/1002 (38%), Gaps = 69/1002 (6%)
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L EE+ +KV E + + DY+ ++ YK +E + K S
Sbjct: 1281 LLEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQSGS 1336
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLAD--------ISQLQSDQVCSEIKSVHLEEQIDAL 671
ES ++QE L+ Y E+ + + +++ ++ +E + E++ +
Sbjct: 1337 ES----VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392
Query: 672 SASKKELALVIENLKLDKEQLYGTIKDLEND-KEDIMNKLQNYI---QENMDLTDKLEKM 727
A+ ++ + E K Q K+L+ +E+++ + + + Q+ + ++L+++
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+E+ AK E ++ +++ I+ +I+ L +E E + + + L
Sbjct: 1453 RQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1511
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
E ++ + +A++L +Q++ + + ++ V A + + L E+ +
Sbjct: 1512 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1571
Query: 848 NKELQKK-NQILLEENQNLQISL--------SDMQQHYNALVEKANRTDLAESESTKYQT 898
+E +++ Q +E + +Q++L +++Q + EK + + + E
Sbjct: 1572 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1631
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
QLR+ + E + + ++E+E +++ N + ++ ++V +K +
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SLA 1685
Query: 959 QLEAQLQEYKNNIE-NLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI---NEINKL 1014
Q EA+ Q+ + E EE EL ++ ++KQ+ + +Q + E+ +L
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745
Query: 1015 NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS 1074
A +Q +++ L +++ Q + + A+ ME + ++ +S
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805
Query: 1075 KQHNEELQILVREQDDQIKELKE--TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXX 1132
+ +E+ + + + + +EL E +L K + + +A V
Sbjct: 1806 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1865
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
LK E E ++E+ E+ +L + + Q L + H
Sbjct: 1866 LAAIGEATRLKT-EAEIALKEKEAENERLRRLAED------EAFQRRRLEEQAAQHKADI 1918
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV--DQRGFEIAELWKQHLAQREADF 1250
+E++ QL+ + L+ R + + + FE A K A+ E +
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELELEL 1975
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ L + E + Q + +EE + E+V Q L +EE R Q
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---QKSLAAEEEAAR--Q 2030
Query: 1311 EKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNI 1370
K A + ++E L++++E+ + + Q+ ++ ++
Sbjct: 2031 RKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 1371 NEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQR 1430
+E Q + A + E Q E + ++ ++ E L Q
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-AERLKQS 2147
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+E R Q + E L E E E A R E A + ++E+E+ K E
Sbjct: 2148 AEEQAQARAQA---QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEMEKHKKFAE 2202
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIE 1532
++ + + +++ L LEE + N + L+ + E
Sbjct: 2203 QTLR--QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
>AF212162-1|AAF23015.2| 2096|Homo sapiens ninein protein.
Length = 2096
Score = 88.2 bits (209), Expect = 2e-16
Identities = 235/1152 (20%), Positives = 479/1152 (41%), Gaps = 115/1152 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E E A+ QE LK+ L E K ++ E+ + LN + + + ++
Sbjct: 870 ELTQECAEAQELLKETLKRE-KTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDL 928
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
+ Q D ++ S+K +R EE+ L Q A + L+ +++D
Sbjct: 929 RNVSETQQSLLSDQILELKSSHKRELREREEV--LCQAGASEQLASQRLERLEMEHDQEG 986
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
++ K++ MEN+ + + + ++ ++ E+ LQ K E++ + +S LQS
Sbjct: 987 Q---EMMSKLLAMENIHKATCETA---DRERAEMSTEISRLQSKIKEMQQATSPLSMLQS 1040
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIEN--LKLDKEQLYG-TIKDLENDKEDIMNK 709
C I +E ALS ++ L+ EN + L +++ + +K+ +I ++
Sbjct: 1041 G--CQVIGEEEVEGD-GALSLLQQGEQLLEENGDVLLSQQRAHEQAVKENVKMATEI-SR 1096
Query: 710 LQNYIQE---NMDLTDKLEKMSAEKISELLAKIN-HEEQSKIQTQFGIDAKIQERDLYIE 765
LQ +Q+ + ++ L++ + E + +Q++ + G+ + DL
Sbjct: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDG 1156
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ S S + R E I E+ S+E ++ S +E + E Q +L
Sbjct: 1157 EVRDLGSTGTSSVQRQEVKI---EESEASVEGFSELENS--EETRTESWELKNQISQLQE 1211
Query: 826 RLAVLM-DHDRVVEKQLLEIEHENKELQKKNQILL---EENQNLQISLSDMQQHYNALVE 881
+L +L D DR EK+ ++ + L+KK +IL E + ++ D+ + + L E
Sbjct: 1212 QLMMLCADCDRASEKKQ-DLLFDVSVLKKKLKILERIPEASPKYKLLYEDVSRENDCLQE 1270
Query: 882 KAN----RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
+ R D A + + ++ L+ LK++ +T + +K ++++IE N ++
Sbjct: 1271 ELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFL-SLEKSYDEVKIE-NEELN 1328
Query: 938 SAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM----NVEELNKMNLELIDK-- 991
+ L K EK E V Q ++ ++ENL + N+ +LN+ E + +
Sbjct: 1329 VLVLR---LQGKIEKLQESVVQ-RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR 1384
Query: 992 ---HVQKQQTQSPDYTE---QYI-----NEINKLNALLKQKDEEIIALNQKI---NNAQV 1037
HV ++ Q Y E Q + +EI L+ ++ E NQ I N +
Sbjct: 1385 SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLL 1444
Query: 1038 SYMSMVSDYESKLAQFT---TKLENMEEEM-QRVS-----KQLLDSKQHNEELQILVREQ 1088
+ +++ +A+ TKL+ + ++ +RV+ K +L + EEL+ ++ +
Sbjct: 1445 GFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDL 1504
Query: 1089 DDQIKELKETK--LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
E+++ L +E + E I+ + I ++++ +++ Q+
Sbjct: 1505 QITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE-DSISNLKLGTLNGSQEEMWQK 1563
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL------- 1199
E QE + +Q+ L ++ E K QL+ NTEL+ + NQE++ +L
Sbjct: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623
Query: 1200 ---------KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREAD 1249
S LE+ E NL + + S+ V E++E+ Q H+ Q+E
Sbjct: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1683
Query: 1250 FQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK---E 1303
K E E QL S ++Q + SV S ++ K E++ S +KL E
Sbjct: 1684 LLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE 1743
Query: 1304 EHLRNLQEKYADVINQIEILRSEI--EDEKVA-FXXXXXXXXXXXXXXXXDLRTENQSYK 1360
+ ++++ +Q L+S++ EKV DLR Q K
Sbjct: 1744 HRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQE-K 1802
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKT 1420
+ +Q +++++++ S +L H + + ++Q+
Sbjct: 1803 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE- 1861
Query: 1421 HEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
+E T+ Q N + +L +++ L ES L L H+ + +
Sbjct: 1862 NERLQTMVQ------NTKAELTHSREKVRQL----ESNL----LPKHQKHLNPSGTMNPT 1907
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
E E++ L E + E N++V+++N +LE+E+ + L+ +++++ E+
Sbjct: 1908 EQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQELETIHLENEGLKKKQVKLDEQLMEM 1966
Query: 1541 TNLQNMVRASSS 1552
+L++ S S
Sbjct: 1967 QHLRSTATPSPS 1978
Score = 83.8 bits (198), Expect = 5e-15
Identities = 132/630 (20%), Positives = 284/630 (45%), Gaps = 48/630 (7%)
Query: 492 EIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFS-KV 550
E++ +++L KLK E++T L + D + + + K + +Q T KV
Sbjct: 1461 ELEKTKLQELTRKLK---ERVTILVKQKDVLSHG--EKEEELKAMMHDLQITCSEMQQKV 1515
Query: 551 SDSNKEIVRLTEELHHLSQKVAELEEEKG--NLQLHLVDYDSGRMIESD--VYKKMIEME 606
E +L +E L ++ L EE NL+L ++ M + V ++ ++
Sbjct: 1516 ELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQ 1575
Query: 607 NLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEE 666
+ E K IS L+ + L E L QK + ++KL +++Q ++ +C + K E
Sbjct: 1576 KMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK----EP 1631
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI--QENMDLTDKL 724
AL ++E + E L+ K Q + LE + ++ K+Q +I QEN L D+L
Sbjct: 1632 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQENHLLKDEL 1689
Query: 725 EKMSAEKISELLAKINHEEQSKIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEE 783
EKM L+ Q KI + + K+ +E++ E + S + K ++ LE
Sbjct: 1690 EKMKQLHRCPDLSDF----QQKISSVLSYNEKLLKEKEALSEELNSCVDKL-AKSSLLEH 1744
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQL 841
IA M+ + S E ++ L S L Q+ E T+Q L +++ + RV +++
Sbjct: 1745 RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNL--QMSRMKSDLRVTQQEK 1802
Query: 842 LEIEHENKELQKKNQILLEENQNLQIS-----LSDMQQH--YNALVEKANRTD-LAESES 893
++ E L K+ Q ++ +I+ L + Q+ ++ L N L E+
Sbjct: 1803 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1862
Query: 894 TKYQTQLRDLESNL----KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ QT +++ ++ L +++ L+ + +K + T+ E ++ ++
Sbjct: 1863 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKREC--DQ 1920
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-----HVQKQQTQSPDYT 1004
++K + +Q+ + +E +++ E L K ++L ++ H++ T SP
Sbjct: 1921 FQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPS-P 1979
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
+ ++ + A E+ + L +++ A+ + + E++ ++ T N E+ +
Sbjct: 1980 HAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLV 2039
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ +++++ +Q + ++ L++E+ +Q+KE
Sbjct: 2040 TVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2069
Score = 67.3 bits (157), Expect = 4e-10
Identities = 168/845 (19%), Positives = 332/845 (39%), Gaps = 57/845 (6%)
Query: 499 KDLIEKLKSAEEQITQLNDEIDAA---NKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+D+ + +E++ + D A NK + + +LK+M++ + F + S
Sbjct: 1259 EDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYD 1318
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ EEL+ L V L+ + LQ +V + E+ + IE + L+
Sbjct: 1319 EVKIENEELNVL---VLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG---NILQL 1372
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
LE + V+ +H + ++ + L +QL EI +H Q
Sbjct: 1373 NQTLE-ECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRV 1431
Query: 676 KELALVIENLKL----DKE-QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
+ ++ EN L DK Q TI +LE +K + + + L + + +S
Sbjct: 1432 QNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHG 1491
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
+ E L + H+ Q T + K++ E ++ E S ++ I L E ++
Sbjct: 1492 EKEEELKAMMHDLQI---TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1548
Query: 791 RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE 850
+ +L +++ + ++ + + L +++ L ++ ++ + E+ +N +
Sbjct: 1549 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1608
Query: 851 LQKKNQILLEENQNLQISLSDMQQH--YNALVEKANRTDLAESESTKYQTQLRDLESNLK 908
Q+K L E NQ L L ++ +AL E+ + E + + Q L S+L+
Sbjct: 1609 NQEK---LQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLE 1665
Query: 909 RITHE--HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
E QT IVQ++ + E+E Q+ D +K + Y +L L+E
Sbjct: 1666 AELSEVKIQTHIVQQENHLLKDELEKMKQLHRC-PDLSDFQQKISSVLSYNEKL---LKE 1721
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
+ E LN V++L K + L++ + + + + Q + L + L E++
Sbjct: 1722 KEALSEELNSCVDKLAKSS--LLEHRIATMKQEQKSWEHQSAS----LKSQLVASQEKVQ 1775
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDS--KQHNEELQIL 1084
L + N + M SD L + E +++E+ + KQL ++ K E+
Sbjct: 1776 NLEDTVQNVNLQMSRMKSD----LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATH 1831
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV 1144
+Q K L KL MN E ++ E + N L
Sbjct: 1832 PSGLHNQQKRLSWDKLDHLMN---EEQQLLWQENERLQTMVQNTKAELTHSREKVRQL-- 1886
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
E + + S +N QE + + + E + + Q+N L+ +LE
Sbjct: 1887 --ESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPAN-RKVSQMNSLEQELE 1943
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEI----AELWKQHLAQREA-DFQKTEH--EL 1257
++ EN+ L +L + R W L Q++A E +L
Sbjct: 1944 TIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQL 2003
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADV 1316
+ QL E + L + +++ T E EQ VT ++ ++ + E+ L+ ++ +
Sbjct: 2004 QRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEK 2063
Query: 1317 INQIE 1321
+NQ++
Sbjct: 2064 VNQLK 2068
Score = 64.1 bits (149), Expect = 4e-09
Identities = 202/1117 (18%), Positives = 457/1117 (40%), Gaps = 81/1117 (7%)
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
H + + K+ E+ K+ + +K+ K+ + L+ A +Q +L EI+ A
Sbjct: 414 HAAIERRNEYNLRKLDEEYKERIA-ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEE 472
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH-----LSQKVAELE------ 575
++ L LK+ + + + ++ E LT +L L++K +L+
Sbjct: 473 NYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEF 532
Query: 576 --EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL-AETRLKAISLLESQKFDLVQELHI 632
+E+ Q+ R+++ V + E+E A+ R+ + L S ++
Sbjct: 533 FLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGG 592
Query: 633 LQQKYDEVEDKLADIS-QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
++ ++ ++ ++ ++++ V ++K H I L ++ E +LD E
Sbjct: 593 IEPEHGLGSEECNPLNMSIEAELVIEQMKEQH-HRDICCLRLELEDKVRHYEK-QLD-ET 649
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ- 750
+ K EN K+ N+ ++ DL +++ ++ + + +L + +HE + + +
Sbjct: 650 VVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQ--AAVLKEAHHEATCRHEEEK 707
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQ 810
+ K++E +++ + L RL ++ A E R L+ A + +EK
Sbjct: 708 KQLQVKLEEEKTHLQE-KLRLQHEMELKARLTQAQASFEREREGLQSSA-----WTEEKV 761
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLS 870
+ + QE E ++ + +VEK LE E KEL +K+Q L+E + +
Sbjct: 762 RGLT----QELEQFHQEQL----TSLVEKHTLEKEELRKELLEKHQRELQEGREKMETEC 813
Query: 871 DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI 930
+++ + +E ++D + + + ++ L+ LE R E + L Q+++E E
Sbjct: 814 NIR---TSQIEAQFQSD-CQKVTERCESALQSLEG---RYRQELKDLQEQQREEKSQWEF 866
Query: 931 EFNTQIESAIRDKKVLNE--KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
E + + +++L E K EK V E ++ E K E+LN V E ++ +L
Sbjct: 867 EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQDL 925
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI--IALNQKINNAQVSYMSMVSDY 1046
D +TQ ++Q + + L++++E + ++++ + ++ + M D
Sbjct: 926 EDLR-NVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQ 984
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI 1106
E + + +KL M E + + + + D + E+ + +IKE+++ M
Sbjct: 985 EGQ--EMMSKLLAM-ENIHKATCETAD--RERAEMSTEISRLQSKIKEMQQATSPLSM-- 1037
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE---EEFIQERSVLQEQSAK 1163
G + E D A ++ + + ++ E+ ++E + + ++
Sbjct: 1038 -LQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSQQRAHEQAVKENVKMATEISR 1096
Query: 1164 LNTELQECYTKIIQLETLN---TELTGHDVVNQEQINQLKSKLEQLNTENDNLLS----- 1215
L LQ+ ++ L+ TE G+ E Q + ++LS
Sbjct: 1097 LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDG 1156
Query: 1216 TVAELRSSISSAVDQRGFEI--AELWKQHLAQRE-ADFQKTEH-ELRVQLSAFESKYEQL 1271
V +L S+ +S+V ++ +I +E + ++ E ++ +TE EL+ Q+S + + L
Sbjct: 1157 EVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMML 1216
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+++++ + + + + L+ E + Y DV + + L+ E+ +
Sbjct: 1217 CADCDRASEKKQDLLFDVSVLKKKLKILERIPEASPKYKLLYEDVSRENDCLQEELRMME 1276
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
+ L+ E + +++ E + L++ + ++K +
Sbjct: 1277 TRYDEALENNKELTAEVFR-LQDELKKMEEVTE-TFLSLEKSYDEVKIENEELNVLVLRL 1334
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
++ + V++ L ++ + E + Q N E ++ IE+
Sbjct: 1335 QGKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1393
Query: 1452 TYEK---ESELAIL-RLKMHENANHYETMQKESEIERV--KLIEELNVKITESVSLNKQV 1505
E E +L ++K HE A + T+Q E RV ++I E N + + Q
Sbjct: 1394 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQH 1453
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
LE E K E+ L+ + +V D +++
Sbjct: 1454 QATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1490
Score = 60.5 bits (140), Expect = 5e-08
Identities = 137/715 (19%), Positives = 289/715 (40%), Gaps = 69/715 (9%)
Query: 839 KQLLE-IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
+ LLE ++ +E +K L + + + S++ H+ A +E+ N +L + + +Y+
Sbjct: 376 RHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHH-AAIERRNEYNLRKLDE-EYK 433
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
++ L++ L++ E + ++ Q K+ +E +IE A ++ + ++ +++
Sbjct: 434 ERIAALKNELRK---EREQILQQAGKQ----RLELEQEIEKAKTEENYIRDRLALSLKEN 486
Query: 958 TQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
++LE +L E N E L NK+ L + +K P E ++ E +L +
Sbjct: 487 SRLENELLE---NAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQE-ERLTQM 542
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
+ + + L +++ Q S + +Y ++ L+N E + ++ +H
Sbjct: 543 RNEYERQCRVLQDQVDELQ----SELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEP-EH 597
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
L E+ + + E +L E + I +E + D + +
Sbjct: 598 G-----LGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLE-LEDKVRHYEKQLDETVV 651
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
+ ++ E L++Q + L E+ E + L+ + E T ++E+
Sbjct: 652 SCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCR---HEEEKK 708
Query: 1198 QLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL 1257
QL+ KLE+ T L E+ EL K L Q +A F++ L
Sbjct: 709 QLQVKLEEEKTHLQEKLRLQHEM----------------EL-KARLTQAQASFEREREGL 751
Query: 1258 RVQLSAF-ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
Q SA+ E K L ++ QE+ +V + + + + E+H R LQE +
Sbjct: 752 --QSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM 809
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE-NQSYKQMQEQSILNINEENA 1375
+ I S+IE + F L Q K +QEQ EE +
Sbjct: 810 ETECNIRTSQIEAQ---FQSDCQKVTERCESALQSLEGRYRQELKDLQEQQ----REEKS 862
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
Q + + + K + T + ++ E+ +KT++ + +
Sbjct: 863 QWEFEKDELTQECAEAQELLKET-LKREKTTSLVLTQEREMLEKTYK------EHLNSMV 915
Query: 1436 NVRQQLVEYEKRIEDLTYEKESELAILRLKMHE--NANHYETMQKESEIERVKLIEELNV 1493
RQQL++ +EDL E++ ++L ++ E +++ E ++E + + E+L
Sbjct: 916 VERQQLLQ---DLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLAS 972
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
+ E + + E + + + +A N + E + E ++ EI+ LQ+ ++
Sbjct: 973 QRLERLEMEHD-QEGQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK 1026
>AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant 2
protein.
Length = 1715
Score = 88.2 bits (209), Expect = 2e-16
Identities = 151/767 (19%), Positives = 334/767 (43%), Gaps = 74/767 (9%)
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEK 578
I KN+ K K ++ T+ +V S ++I EE+ L K+ + E+E+
Sbjct: 894 IRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKER 953
Query: 579 GNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD 638
L+L+ D R+ S++ ++ + N E+ + + +++ +E+ LQ +YD
Sbjct: 954 NELRLN-SDRLESRI--SELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYD 1010
Query: 639 E-------VEDKLADISQLQSDQVCSEIKS--------VHLEEQIDALSASKKELALVIE 683
+E ++ + +++ ++ E+ + E + + +KK L E
Sbjct: 1011 ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1070
Query: 684 N-LKLD---KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+ L+++ K QL + DL+ D E+ LQ ++ LT +L+ + +
Sbjct: 1071 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR-- 1128
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESE-LSKYKSRICRLEESIAVMEDRRYSLERK 798
NHE + K Q +F + + E ++ E L + K + L E+ ++ + LE K
Sbjct: 1129 NHELEKK-QRRFDSELSQAHEEAQREKLQREKLQREKDML--LAEAFSL----KQQLEEK 1181
Query: 799 ADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ + Q+ + + + QE + LA + R +E ++ + E E E
Sbjct: 1182 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1241
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
Q+L + L++ + M+Q ++ E +R + E Q +L+ +E L+ +E +
Sbjct: 1242 QMLEQAKLRLEMEMERMRQTHSK--EMESRDEEVEEARQSCQKKLKQMEVQLEE-EYEDK 1298
Query: 916 TLIVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN---- 970
++++K+E+E + Q+ +K L + ++ + + L KN+
Sbjct: 1299 QKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSK 1358
Query: 971 --IENLNMNVEE-----------LNKMNLELIDKHVQ-----KQQTQSPDYTEQYINEIN 1012
I L +EE M +E+ D H+Q K +T + + E N
Sbjct: 1359 REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN 1418
Query: 1013 KLNALLKQKDEEIIAL--NQKINNAQVSY-MSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ L++ E++ L K AQ S ++ ++D +++L + + + ++E++Q +
Sbjct: 1419 EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1478
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMI--ISSTIEPMSDDAN 1126
Q+ +Q + + LV Q+ +I+EL ET+L FE + + E + + +E ++++ +
Sbjct: 1479 QVEFLEQSMVD-KSLVSRQEAKIREL-ETRLEFERTQVKRLESLASRLKENMEKLTEERD 1536
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
L+ ++ + +E L + A+ + + E + LE N L
Sbjct: 1537 QRIAAENREKEQNKRLQ-RQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1595
Query: 1187 GHDVVNQEQINQLKSKL--EQLNTENDNLLSTVAELRSSISSAVDQR 1231
+ ++I L++ + E + EN++L+++ + S + S ++ R
Sbjct: 1596 ADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGD--SDVDSELEDR 1640
Score = 87.8 bits (208), Expect = 3e-16
Identities = 142/722 (19%), Positives = 300/722 (41%), Gaps = 64/722 (8%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E ++ I +L + E R L +D+L S + E SE T E
Sbjct: 929 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELT-DERNTGESA 984
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
+ L+D + + L E E KELQ + L ++ + +++ + + + A + D
Sbjct: 985 SQLLDAETA---ERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDD 1041
Query: 888 LAESE-STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
A E KY+ +R+++ KR+ E + K E+E + Q+E + D +
Sbjct: 1042 DAGGEWRLKYERAVREVDFTKKRLQQEFED-----KLEVEQ---QNKRQLERRLGDLQAD 1093
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+E+ ++ ++ QL+ + Q +++ +++E N EL K + S + E
Sbjct: 1094 SEESQRALQ---QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1150
Query: 1007 YINEINKLNALLKQKD---EEIIALNQKINNAQVS---YMSMVSDYESKLAQFTTKLENM 1060
++ + L ++KD E +L Q++ + + V E++L +++
Sbjct: 1151 QREKLQR-EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1209
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEP 1120
E + +V KQL D + ++ + + EQ I+ L++ KL EM + E M + + E
Sbjct: 1210 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEM---ERMRQTHSKEM 1266
Query: 1121 MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ---SAKLNTELQECYTKIIQ 1177
S D V+ ++VQ EEE+ ++ VL+E+ KL T + + +
Sbjct: 1267 ESRD-EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE 1325
Query: 1178 LET-----------------LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAEL 1220
E L + + ++ +I QLK++LE E++ + +
Sbjct: 1326 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLE----ESEFTCAAAVKA 1381
Query: 1221 RSSISSAVDQRGFEIAELWKQHLAQRE--ADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
R ++ ++ +I ++ K A E + Q+ ++E++ +L + +L+ +++
Sbjct: 1382 RKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAA 1441
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+ + + Q+ LQ +L++ + + LQEK + +Q+E L + D+ +
Sbjct: 1442 VAQASRDLA---QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEA 1498
Query: 1339 XXXXXXXXXXXXDLRTEN-QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND 1397
+ + +S ++++ + EE Q + ++ D
Sbjct: 1499 KIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRD 1558
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES 1457
+ ++ EL K++E +K HE + L ++++ L KRI DL E
Sbjct: 1559 TKEEMGELAR----KEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED 1614
Query: 1458 EL 1459
E+
Sbjct: 1615 EM 1616
Score = 80.6 bits (190), Expect = 4e-14
Identities = 140/719 (19%), Positives = 299/719 (41%), Gaps = 59/719 (8%)
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLAESESTKY 896
E+Q+ + E ++L+ K + +E L+++ ++ + L E + + ES S
Sbjct: 929 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 988
Query: 897 QTQLRD---LESNLKRITHEHQTLIVQKK-KEIEDLEIEF--NTQIESAIRDKKVLNE-- 948
+ + E +K + ++ L Q + E+E +E +I + D E
Sbjct: 989 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 1048
Query: 949 -KYEKNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
KYE+ + V + +LQ E+++ +E VE+ NK LE +Q +S +Q
Sbjct: 1049 LKYERAVREVDFTKKRLQQEFEDKLE-----VEQQNKRQLERRLGDLQADSEESQRALQQ 1103
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ +L A L+ D ++ Q++ N ++ E K +F ++L EE QR
Sbjct: 1104 LKKKCQRLTAELQ--DTKLHLEGQQVRNHEL---------EKKQRRFDSELSQAHEEAQR 1152
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
Q ++ + L Q++E F + E + + + D+A+
Sbjct: 1153 EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1212
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERS----VLQEQSAKLNTELQEC-YTKIIQLETL 1181
KV+++EE + E++ +L++ +L E++ T ++E+
Sbjct: 1213 ---LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1269
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR---SSISSAVDQRGFEIAEL 1238
+ E+ Q+++ Q++ +LE+ + +L EL +++S V++R FE +
Sbjct: 1270 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1329
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYE--QLLDSVQSS-----TQEETNKIVTMEQ 1291
++ L + +A + L ++ SK E QL + ++ S + K + +E
Sbjct: 1330 LRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE- 1388
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L ++ D + L+E+ + + + +++ +E+++ D
Sbjct: 1389 IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD 1448
Query: 1352 LRTENQSYKQMQEQSILNIN-EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
L N Q++E + +E Q +S V+ EAK+ EL +LE
Sbjct: 1449 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1508
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ +++ ++ L + ++ R Q + E R EKE + R
Sbjct: 1509 FERTQV-KRLESLASRLKENMEKLTEERDQRIAAENR------EKEQNKRLQRQLRDTKE 1561
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQ 1529
E +KE+E R K E++++ E+ + + Q A+L A + + ++Q A+E++
Sbjct: 1562 EMGELARKEAEASRKKHELEMDLESLEAANQSLQ-ADLKLAFK----RIGDLQAAIEDE 1615
Score = 78.6 bits (185), Expect = 2e-13
Identities = 142/726 (19%), Positives = 297/726 (40%), Gaps = 67/726 (9%)
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
F V+ L +Q +++ +K +I QL+S +E + L D L + EL +
Sbjct: 916 FTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELT 975
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSAEKISELLAKINHE 742
+ + E + D E + K +Q D L ++E M E + L +
Sbjct: 976 DERNTGESA-SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA--- 1031
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQ 801
++I + D E L E E+ K R+ + E+ + V + + LER+
Sbjct: 1032 --AEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGD 1089
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L + +E Q+A + + L L H + + E+E + + + EE
Sbjct: 1090 LQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1149
Query: 862 NQNLQISLSDMQQHYNALVEKA----NRTDLAESESTKYQTQLRDLESNLKRITHEH--- 914
Q ++ +Q+ + L+ +A + + + + + ++ LE+ L+ I+ +
Sbjct: 1150 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1209
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + + KK++ DLE + Q E + + + ++E Q + +E+
Sbjct: 1210 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1269
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ VEE + QK+ Q E+ + K+ ++ + ++ L+ ++N
Sbjct: 1270 DEEVEEAR--------QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1321
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV--REQDDQI 1092
D+ES+ + + ++++R L D++ + L+ + + Q+
Sbjct: 1322 ---------RDFESE--------KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1364
Query: 1093 K-ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
K +L+E++ T + + M + IE + + D ++Q E+ I
Sbjct: 1365 KNQLEESEFTCAAAVKARKAMEVE--IEDLHLQID--DIAKAKTALEEQLSRLQREKNEI 1420
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
Q R L+E +N +++ + Q D+ QIN L+++LE+ N E
Sbjct: 1421 QNR--LEEDQEDMNELMKKHKAAVAQ--------ASRDLA---QINDLQAQLEEANKEKQ 1467
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
L + L+S + ++Q + + + +Q RE + + E E R Q+ ES +L
Sbjct: 1468 ELQEKLQALQSQV-EFLEQSMVDKSLVSRQEAKIRELE-TRLEFE-RTQVKRLESLASRL 1524
Query: 1272 LDSVQSSTQEETNKIVT----MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
++++ T+E +I EQ LQ +L+D +E + L K A+ + L ++
Sbjct: 1525 KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL 1584
Query: 1328 EDEKVA 1333
E + A
Sbjct: 1585 ESLEAA 1590
Score = 49.6 bits (113), Expect = 9e-05
Identities = 105/547 (19%), Positives = 221/547 (40%), Gaps = 58/547 (10%)
Query: 1075 KQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ +EE+Q L + + KE E +L N + E I T E ++D+ N +
Sbjct: 933 RNKDEEIQQLRSKLEKAEKERNELRL----NSDRLESRISELTSE-LTDERNTGESASQL 987
Query: 1135 XXXXXXX-LKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN 1192
L+ ++E + +Q + L++Q + E+ E ++I+ +N E+ D
Sbjct: 988 LDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEA--RLIRAAEINGEVDDDDAGG 1045
Query: 1193 QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQK 1252
+ ++ K E+ E D T L+ + E+ + K+ L +R D Q
Sbjct: 1046 EWRL-----KYERAVREVD---FTKKRLQQEFEDKL-----EVEQQNKRQLERRLGDLQA 1092
Query: 1253 TEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
E + L + K ++L +Q +T + +QV + ++L+ K+ + +
Sbjct: 1093 DSEESQRALQQLKKKCQRLTAELQ-----DTKLHLEGQQVRN--HELEKKQRRFDSELSQ 1145
Query: 1313 YADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINE 1372
+ + ++ R +++ EK D+ Q + E + +I+
Sbjct: 1146 AHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSL-EAELQDISS 1204
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAE------AKVLELTHQLELK-DSEIYQKTHEYTI 1425
+ ++ + S +V D E A +++ Q +L+ + E+ + ++
Sbjct: 1205 QESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSK 1264
Query: 1426 TLTQRNDEFENVRQQL--------VEYEKRIED----LTYEKESELAILRLKMHENANHY 1473
+ R++E E RQ V+ E+ ED L ++E E + L N +
Sbjct: 1265 EMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDF 1324
Query: 1474 ETMQK-ESEIERVK-LIEELNVKITE---SVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E+ ++ +++R K L+ + + + S +++A+L LEE A +
Sbjct: 1325 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKA 1384
Query: 1529 QEIEIVTLN---DEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVP 1585
E+EI L+ D+I + + S++Q+ + + + E ++ M K AV
Sbjct: 1385 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKA-AVA 1443
Query: 1586 RAELDLA 1592
+A DLA
Sbjct: 1444 QASRDLA 1450
Score = 46.0 bits (104), Expect = 0.001
Identities = 92/457 (20%), Positives = 196/457 (42%), Gaps = 47/457 (10%)
Query: 307 KTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLAT--------MGTESKA 358
+ E+++ S E + L K + L L +++ +EL+ + T + E +
Sbjct: 1196 EAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEM 1255
Query: 359 VSSPSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ SR A + + Q+ + + DK+ E +LE + +L
Sbjct: 1256 ERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATL 1315
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS---LIHVGTNTED 474
+ D V++ SEK D AQL L+H ++ PS + + E+
Sbjct: 1316 S-DQVNRRDFESEKRLRKDLKRTKALLAD---AQLMLDHLKN-SAPSKREIAQLKNQLEE 1370
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVK-DLIEKLKSA-EEQITQLNDE-------IDAANKN 525
+ ++ + EI+D++++ D I K K+A EEQ+++L E ++ ++
Sbjct: 1371 SEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQED 1430
Query: 526 MIKVKSNHKLKLKQMQKTI----DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
M ++ HK + Q + + D +++ ++NKE L E+L L +V LE+
Sbjct: 1431 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---- 1486
Query: 582 QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE 641
+VD + + S K+ E+E E + LES L + + L ++ D+
Sbjct: 1487 ---MVD----KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQ-R 1538
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + Q+ ++ +++ +E++ L+ + E + L++D E L + L+
Sbjct: 1539 IAAENREKEQNKRLQRQLRDT--KEEMGELARKEAEASRKKHELEMDLESLEAANQSLQA 1596
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAEKISEL 735
D + + LQ I++ M+ + + +++E S++
Sbjct: 1597 DLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDV 1633
>X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa protein.
Length = 976
Score = 87.8 bits (208), Expect = 3e-16
Identities = 130/588 (22%), Positives = 275/588 (46%), Gaps = 74/588 (12%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVN------------VKDLIEKLKSAEEQITQLNDEID 520
ED +I ++++ K+E+ND+ K V+ +KDL L+ + +++ QL ++
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
Query: 521 AANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
++N+ + ++ H L K+++ + + + K L E+L ++ + +L EEK
Sbjct: 305 LQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQK---ALEEDLQIATKTICQLTEEK- 359
Query: 580 NLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + + R S V + + +E L T + + E Q L E LQ+
Sbjct: 360 --ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME---LQK 414
Query: 636 KYDEVED--KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K E+E+ KL + +++ + E+K V E+ + L K+ + E LK +++L
Sbjct: 415 KSSELEEMTKLTNNKEVELE----ELKKVLGEK--ETLLYENKQFEKIAEELKGTEQELI 468
Query: 694 GTIKDLENDKEDIMNKL-------QNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
G ++ E + D+ +L Q Y +E DL +LE K +EL + N ++
Sbjct: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLEN 527
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
K TQ + + L ++N + +++ K + R+ + I +++ L + + +
Sbjct: 528 KELTQ-----ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
L++K+ + +E N L +++ K + E++ ENK L+KK ++
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENK---NKYIEELQQENKALKKKGTA-----ESK 634
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q+++ +++ + L ++ + E T YQ ++ D K+I+ E+ V+K K I
Sbjct: 635 QLNVYEIKVNKLELELESAKQKFGEITDT-YQKEIED-----KKISEENLLEEVEKAKVI 688
Query: 926 ED----LEIEFNTQIESAIRDKKVLNEKYEKNIE-YVTQLEAQLQEYKNNIE---NLNMN 977
D L+ E + + + I + L EK++ + + + +++L YK+ + +L +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRAS 748
Query: 978 VE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+E EL+ + EL+ V+KQ + E+ E + A LK+K ++
Sbjct: 749 LEIELSNLKAELLS--VKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
Score = 79.4 bits (187), Expect = 1e-13
Identities = 146/703 (20%), Positives = 288/703 (40%), Gaps = 66/703 (9%)
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKL-- 537
Q++ K + N +I + K I++L+ E+++ +E NK++IK + H L
Sbjct: 129 QKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVA------ELEEEKGNLQLHLV---DY 588
+ ++ + K +E ++ +L++ +K+ ++ E L++H DY
Sbjct: 188 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAHGELRVQAENSRLEMHFKLKEDY 247
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ + +E + K++ + E L I+ E++ DL L + K +++E+K +
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK----T 303
Query: 649 QLQSDQVCSEI-KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+LQS+ + I K HL ++++ + S + + L+ D + TI L +KE M
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
Query: 708 NKLQNYIQENMDLTDKLEKM--SAEKI--SELLAKINHEEQSKIQTQF--GIDAKIQERD 761
+ + + + E S E++ +E +E+Q KI T ++++E
Sbjct: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYS-----LERKADQLGSYLQEKQKAYSEY 816
N E EL + K + E+ + E++++ L+ +L LQ ++K +
Sbjct: 424 KLTNNKEVELEELKKVLG--EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
IQ + + ++ +L + +N EL L EN+ L SDM
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFN 933
E N E K L++ E+ L+ + + QK+ E++ D E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 934 TQIESAIRDK-KVLNEKYEKNIEYV---TQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + +K K + E ++N T QL Y+ + L + +E + E+
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNA-------LLKQKDE-------EIIALNQKINNA 1035
D + QK+ E + E+ K L K+ D+ E++AL +K +
Sbjct: 662 DTY-QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 1036 QVS-----------YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
Y S + S A +L N++ E+ V KQL ++ E+L+
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 1085 VREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDAN 1126
+E +KE K+ K TF + P+ + S + + N
Sbjct: 781 AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRN 823
Score = 71.3 bits (167), Expect = 3e-11
Identities = 149/681 (21%), Positives = 276/681 (40%), Gaps = 70/681 (10%)
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDK---------LEKMSAEKIS 733
EN K+ + Q I++L+ E + KL+ IQEN DL + L K + + +
Sbjct: 136 ENRKIIEAQRKA-IQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSA 194
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
E K +E + Q ++ I++ + EL + ++ RLE + ED
Sbjct: 195 EKTKKYEYEREETRQVYMDLNNNIEK----MITAHGEL-RVQAENSRLEMHFKLKEDYE- 248
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNR---LAVLMDHDRVVEKQLLE---IEHE 847
++ + + +K+K S IQ E N+ L L++ R QL E ++ E
Sbjct: 249 KIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSE 308
Query: 848 N-KELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST-KYQTQLRDLES 905
N K+ +K L +E +++++SL AL E + T + +TQ+ ES
Sbjct: 309 NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQME--ES 366
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
N R H + +V EF T + S + ++ EKN + + L +LQ
Sbjct: 367 NKARAAH---SFVV----------TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQ 413
Query: 966 EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI 1025
+ + +E + + ++ LE + K + +++T Y + + K+ LK ++E+
Sbjct: 414 KKSSELEEMT-KLTNNKEVELEELKKVLGEKETLL--YENK---QFEKIAEELKGTEQEL 467
Query: 1026 IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV 1085
I L Q + V D E +L TT + +E++ + +L + K N EL
Sbjct: 468 IGLLQ-------AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHC 520
Query: 1086 REQDDQIKEL-KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK 1143
+ + KEL +ET +T E+ + + E M N+ ++
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVR 580
Query: 1144 ---VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
Q+ +E + +E L +++ I +L+ N L +Q+N +
Sbjct: 581 EELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYE 640
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE----IAELWKQHLAQREADFQKTEHE 1256
K+ +L E ++ E+ + ++ + + E+ K + EA + E +
Sbjct: 641 IKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEID 700
Query: 1257 LRVQ-----LSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQ 1310
R Q + A K++ D + E + EQ +SL+ L E L NL+
Sbjct: 701 KRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNLK 757
Query: 1311 EKYADVINQIEILRSEIEDEK 1331
+ V Q+EI R E E K
Sbjct: 758 AELLSVKKQLEIEREEKEKLK 778
Score = 65.7 bits (153), Expect = 1e-09
Identities = 114/571 (19%), Positives = 229/571 (40%), Gaps = 39/571 (6%)
Query: 1008 INEINKLNALLKQKDEEIIALNQ---KINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
I E+ N + K EE I N+ K NNA +++ + ++ A+ T K E EE
Sbjct: 148 IQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREET 207
Query: 1065 QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDD 1124
++V L N ++ ++ + + + ++L + K + I + +
Sbjct: 208 RQVYMDL------NNNIEKMITAHGELRVQAENSRLEMHFKL-KEDYEKIQHLEQEYKKE 260
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTE 1184
N+ + +++ E+E +++ + L E+S +L+E TK+ Q E L
Sbjct: 261 INDKEKQVSLLL-----IQITEKENKMKDLTFLLEESRDKVNQLEE-KTKL-QSENLKQS 313
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
+ + +E + +K L++ + L + +I +++ ++ E K A
Sbjct: 314 IEKQHHLTKE-LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAA 372
Query: 1245 QR--EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+F+ T L L + + E+ D ++ T E K +E++T L N + +
Sbjct: 373 HSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVE 432
Query: 1303 EEHLRNLQEKYADVI---NQIEILRSEI---EDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
E L+ + + ++ Q E + E+ E E + + T
Sbjct: 433 LEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSE 492
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR--VNDAEAKVLELTHQLE---- 1410
Q Y + E L EN +LK + + + LEL +Q E
Sbjct: 493 QYYSK--EVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN 550
Query: 1411 --LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
++ + ++ T TQ +E E VR++L + ++ + E LR K E
Sbjct: 551 NKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR-KQVE 609
Query: 1469 NANHY-ETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
N N Y E +Q+E++ + K E + +NK EL A ++ T+ Q +E
Sbjct: 610 NKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 1528 NQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
+++I L +E+ + ++ + K+QK +
Sbjct: 670 DKKISEENLLEEVEKAK-VIADEAVKLQKEI 699
Score = 64.1 bits (149), Expect = 4e-09
Identities = 100/480 (20%), Positives = 209/480 (43%), Gaps = 36/480 (7%)
Query: 297 KQSIEPSCEEKTEIEE-KGSLE--IANMTELTKKIELLEHLNCQIRQTNK-ELENKLATM 352
KQSIE E+E+ K SL+ ++ L + +++ CQ+ + + ++E
Sbjct: 311 KQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKAR 370
Query: 353 GTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINK-NEIAKL- 410
S V+ L + R +++ QL + L + KK ++ E+ KL
Sbjct: 371 AAHSFVVTEFETTVCSL--EELLRTEQQRLEKNEDQL--KILTMELQKKSSELEEMTKLT 426
Query: 411 ---EMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIH 467
E+ ++ L K L +KE ++ E + LI LQ ++ + +
Sbjct: 427 NNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT 486
Query: 468 VGTNTEDVNEIAKVQEQLKQEL-NDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
T +E +K + LK EL N+++K+ + KL +++TQ ++ KN
Sbjct: 487 AITTSEQY--YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQ 544
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKV---AELEEEKGNLQ 582
+ +N+K + ++M K I+N + + E+ + EEL +V + EE N
Sbjct: 545 QEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNL 604
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
V+ + + E K ++ + AE++ + ++ K +L EL +QK+ E+ D
Sbjct: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLEL--ELESAKQKFGEITD 662
Query: 643 ---KLADISQLQSDQVCSEI--------KSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
K + ++ + + E+ ++V L+++ID + ++A ++ ++ K Q
Sbjct: 663 TYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEID--KRCQHKIAEMVALMEKHKHQ 720
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS-ELLAKINHEEQSKIQTQ 750
I++ +++ +K Q L +L + AE +S + +I EE+ K++ +
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
>D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein.
Length = 2067
Score = 87.8 bits (208), Expect = 3e-16
Identities = 148/756 (19%), Positives = 330/756 (43%), Gaps = 72/756 (9%)
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEK 578
I KN+ K K ++ T+ +V S ++I EE+ L K+ + E+E+
Sbjct: 1231 IRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKER 1290
Query: 579 GNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD 638
L+L+ D R+ S++ ++ + N E+ + + +++ +E+ LQ +YD
Sbjct: 1291 NELRLN-SDRLESRI--SELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYD 1347
Query: 639 E-------VEDKLADISQLQSDQVCSEIKS--------VHLEEQIDALSASKKELALVIE 683
+E ++ + +++ ++ E+ + E + + +KK L E
Sbjct: 1348 ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1407
Query: 684 N-LKLD---KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+ L+++ K QL + DL+ D E+ LQ ++ LT +L+ + +
Sbjct: 1408 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR-- 1465
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESE-LSKYKSRICRLEESIAVMEDRRYSLERK 798
NHE + K Q +F + + E ++ E L + K + L E+ ++ + LE K
Sbjct: 1466 NHELEKK-QRRFDSELSQAHEEAQREKLQREKLQREKDML--LAEAFSL----KQQLEEK 1518
Query: 799 ADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ + Q+ + + + QE + LA + R +E ++ + E E E
Sbjct: 1519 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1578
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
Q+L + L++ + M+Q ++ E +R + E Q +L+ +E L+ +E +
Sbjct: 1579 QMLEQAKLRLEMEMERMRQTHSK--EMESRDEEVEEARQSCQKKLKQMEVQLEE-EYEDK 1635
Query: 916 TLIVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN---- 970
++++K+E+E + Q+ +K L + ++ + + L KN+
Sbjct: 1636 QKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSK 1695
Query: 971 --IENLNMNVEE-----------LNKMNLELIDKHVQ-----KQQTQSPDYTEQYINEIN 1012
I L +EE M +E+ D H+Q K +T + + E N
Sbjct: 1696 REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN 1755
Query: 1013 KLNALLKQKDEEIIAL--NQKINNAQVSY-MSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ L++ E++ L K AQ S ++ ++D +++L + + + ++E++Q +
Sbjct: 1756 EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1815
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMI--ISSTIEPMSDDAN 1126
Q+ +Q + + LV Q+ +I+EL ET+L FE + + E + + +E ++++ +
Sbjct: 1816 QVEFLEQSMVD-KSLVSRQEAKIREL-ETRLEFERTQVKRLESLASRLKENMEKLTEERD 1873
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
L+ ++ + +E L + A+ + + E + LE N L
Sbjct: 1874 QRIAAENREKEQNKRLQ-RQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1932
Query: 1187 GHDVVNQEQINQLKSKL--EQLNTENDNLLSTVAEL 1220
+ ++I L++ + E + EN++L++++ ++
Sbjct: 1933 ADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDM 1968
Score = 87.8 bits (208), Expect = 3e-16
Identities = 152/763 (19%), Positives = 319/763 (41%), Gaps = 61/763 (7%)
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLAESESTKY 896
E+Q+ + E ++L+ K + +E L+++ ++ + L E + + ES S
Sbjct: 1266 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 1325
Query: 897 QTQLRD---LESNLKRITHEHQTLIVQKK-KEIEDLEIEF--NTQIESAIRDKKVLNE-- 948
+ + E +K + ++ L Q + E+E +E +I + D E
Sbjct: 1326 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 1385
Query: 949 -KYEKNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
KYE+ + V + +LQ E+++ +E VE+ NK LE +Q +S +Q
Sbjct: 1386 LKYERAVREVDFTKKRLQQEFEDKLE-----VEQQNKRQLERRLGDLQADSEESQRALQQ 1440
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ +L A L+ D ++ Q++ N ++ E K +F ++L EE QR
Sbjct: 1441 LKKKCQRLTAELQ--DTKLHLEGQQVRNHEL---------EKKQRRFDSELSQAHEEAQR 1489
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
Q ++ + L Q++E F + E + + + D+A+
Sbjct: 1490 EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1549
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERS----VLQEQSAKLNTELQEC-YTKIIQLETL 1181
KV+++EE + E++ +L++ +L E++ T ++E+
Sbjct: 1550 ---LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1606
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR---SSISSAVDQRGFEIAEL 1238
+ E+ Q+++ Q++ +LE+ + +L EL +++S V++R FE +
Sbjct: 1607 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1666
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYE--QLLDSVQSS-----TQEETNKIVTMEQ 1291
++ L + +A + L ++ SK E QL + ++ S + K + +E
Sbjct: 1667 LRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE- 1725
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L ++ D + L+E+ + + + +++ +E+++ D
Sbjct: 1726 IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD 1785
Query: 1352 LRTENQSYKQMQEQSILNIN-EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
L N Q++E + +E Q +S V+ EAK+ EL +LE
Sbjct: 1786 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1845
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ +++ ++ L + ++ R Q + E R EKE + R
Sbjct: 1846 FERTQV-KRLESLASRLKENMEKLTEERDQRIAAENR------EKEQNKRLQRQLRDTKE 1898
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
E +KE+E R K E++++ E+ + + Q A+L A + + ++Q A+E+ E
Sbjct: 1899 EMGELARKEAEASRKKHELEMDLESLEAANQSLQ-ADLKLAFK----RIGDLQAAIED-E 1952
Query: 1531 IEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD 1573
+E D I +LQ+MV K + + SD ++++D
Sbjct: 1953 MESDENEDLINSLQDMV-TKYQKRKNKLEGDSDVDSELEDRVD 1994
Score = 78.6 bits (185), Expect = 2e-13
Identities = 142/726 (19%), Positives = 297/726 (40%), Gaps = 67/726 (9%)
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
F V+ L +Q +++ +K +I QL+S +E + L D L + EL +
Sbjct: 1253 FTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELT 1312
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSAEKISELLAKINHE 742
+ + E + D E + K +Q D L ++E M E + L +
Sbjct: 1313 DERNTGESA-SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA--- 1368
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQ 801
++I + D E L E E+ K R+ + E+ + V + + LER+
Sbjct: 1369 --AEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGD 1426
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L + +E Q+A + + L L H + + E+E + + + EE
Sbjct: 1427 LQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1486
Query: 862 NQNLQISLSDMQQHYNALVEKA----NRTDLAESESTKYQTQLRDLESNLKRITHEH--- 914
Q ++ +Q+ + L+ +A + + + + + ++ LE+ L+ I+ +
Sbjct: 1487 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1546
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + + KK++ DLE + Q E + + + ++E Q + +E+
Sbjct: 1547 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1606
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ VEE + QK+ Q E+ + K+ ++ + ++ L+ ++N
Sbjct: 1607 DEEVEEAR--------QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1658
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV--REQDDQI 1092
D+ES+ + + ++++R L D++ + L+ + + Q+
Sbjct: 1659 ---------RDFESE--------KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1701
Query: 1093 K-ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
K +L+E++ T + + M + IE + + D ++Q E+ I
Sbjct: 1702 KNQLEESEFTCAAAVKARKAMEVE--IEDLHLQID--DIAKAKTALEEQLSRLQREKNEI 1757
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
Q R L+E +N +++ + Q D+ QIN L+++LE+ N E
Sbjct: 1758 QNR--LEEDQEDMNELMKKHKAAVAQ--------ASRDLA---QINDLQAQLEEANKEKQ 1804
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
L + L+S + ++Q + + + +Q RE + + E E R Q+ ES +L
Sbjct: 1805 ELQEKLQALQSQV-EFLEQSMVDKSLVSRQEAKIRELE-TRLEFE-RTQVKRLESLASRL 1861
Query: 1272 LDSVQSSTQEETNKIVT----MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
++++ T+E +I EQ LQ +L+D +E + L K A+ + L ++
Sbjct: 1862 KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL 1921
Query: 1328 EDEKVA 1333
E + A
Sbjct: 1922 ESLEAA 1927
Score = 54.8 bits (126), Expect = 2e-06
Identities = 101/497 (20%), Positives = 220/497 (44%), Gaps = 53/497 (10%)
Query: 307 KTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLAT--------MGTESKA 358
+ E+++ S E + L K + L L +++ +EL+ + T + E +
Sbjct: 1533 EAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEM 1592
Query: 359 VSSPSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ SR A + + Q+ + + DK+ E +LE + +L
Sbjct: 1593 ERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATL 1652
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS---LIHVGTNTED 474
+ D V++ SEK D AQL L+H ++ PS + + E+
Sbjct: 1653 S-DQVNRRDFESEKRLRKDLKRTKALLAD---AQLMLDHLKN-SAPSKREIAQLKNQLEE 1707
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVK-DLIEKLKSA-EEQITQLNDE-------IDAANKN 525
+ ++ + EI+D++++ D I K K+A EEQ+++L E ++ ++
Sbjct: 1708 SEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQED 1767
Query: 526 MIKVKSNHKLKLKQMQKTI----DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
M ++ HK + Q + + D +++ ++NKE L E+L L +V LE+
Sbjct: 1768 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---- 1823
Query: 582 QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE 641
+VD + + S K+ E+E E + LES L + + L ++ D+
Sbjct: 1824 ---MVD----KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQ-R 1875
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + Q+ ++ +++ +E++ L+ + E + L++D E L + L+
Sbjct: 1876 IAAENREKEQNKRLQRQLRDT--KEEMGELARKEAEASRKKHELEMDLESLEAANQSLQA 1933
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
D + + LQ I++ M+ +D+ E + + +++ K + ++K++ +D++++
Sbjct: 1934 DLKLAFKRIGDLQAAIEDEME-SDENEDL-INSLQDMVTKY-QKRKNKLEGDSDVDSELE 1990
Query: 759 ERDLYIENIESELSKYK 775
+R ++ ++S LSK K
Sbjct: 1991 DR---VDGVKSWLSKNK 2004
>BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex protein
1 protein.
Length = 976
Score = 87.8 bits (208), Expect = 3e-16
Identities = 130/588 (22%), Positives = 275/588 (46%), Gaps = 74/588 (12%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVN------------VKDLIEKLKSAEEQITQLNDEID 520
ED +I ++++ K+E+ND+ K V+ +KDL L+ + +++ QL ++
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
Query: 521 AANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
++N+ + ++ H L K+++ + + + K L E+L ++ + +L EEK
Sbjct: 305 LQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQK---ALEEDLQIATKTICQLTEEK- 359
Query: 580 NLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + + R S V + + +E L T + + E Q L E LQ+
Sbjct: 360 --ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME---LQK 414
Query: 636 KYDEVED--KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K E+E+ KL + +++ + E+K V E+ + L K+ + E LK +++L
Sbjct: 415 KSSELEEMTKLTNNKEVELE----ELKKVLGEK--ETLLYENKQFEKIAEELKGTEQELI 468
Query: 694 GTIKDLENDKEDIMNKL-------QNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
G ++ E + D+ +L Q Y +E DL +LE K +EL + N ++
Sbjct: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLEN 527
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
K TQ + + L ++N + +++ K + R+ + I +++ L + + +
Sbjct: 528 KELTQ-----ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
L++K+ + +E N L +++ K + E++ ENK L+KK ++
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENK---NKYIEELQQENKALKKKGTA-----ESK 634
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q+++ +++ + L ++ + E T YQ ++ D K+I+ E+ V+K K I
Sbjct: 635 QLNVYEIKVNKLELELESAKQKFGEITDT-YQKEIED-----KKISEENLLEEVEKAKVI 688
Query: 926 ED----LEIEFNTQIESAIRDKKVLNEKYEKNIE-YVTQLEAQLQEYKNNIE---NLNMN 977
D L+ E + + + I + L EK++ + + + +++L YK+ + +L +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRAS 748
Query: 978 VE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+E EL+ + EL+ V+KQ + E+ E + A LK+K ++
Sbjct: 749 LEIELSNLKAELLS--VKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
Score = 79.8 bits (188), Expect = 7e-14
Identities = 148/703 (21%), Positives = 288/703 (40%), Gaps = 66/703 (9%)
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKL-- 537
Q++ K + N +I + K I++L+ E+++ +E NK++IK + H L
Sbjct: 129 QKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK-VAELEE-----EKGNLQLHLV---DY 588
+ ++ + K +E ++ +L++ +K + EE E L++H DY
Sbjct: 188 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDY 247
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ + +E + K++ + E L I+ E++ DL L + K +++E+K +
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK----T 303
Query: 649 QLQSDQVCSEI-KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+LQS+ + I K HL ++++ + S + + L+ D + TI L +KE M
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
Query: 708 NKLQNYIQENMDLTDKLEKM--SAEKI--SELLAKINHEEQSKIQTQF--GIDAKIQERD 761
+ + + + E S E++ +E +E+Q KI T ++++E
Sbjct: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYS-----LERKADQLGSYLQEKQKAYSEY 816
N E EL + K + E+ + E++++ L+ +L LQ ++K +
Sbjct: 424 KLTNNKEVELEELKKVLG--EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
IQ + + ++ +L + +N EL L EN+ L SDM
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFN 933
E N E K L++ E+ L+ + + QK+ E++ D E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 934 TQIESAIRDK-KVLNEKYEKNIEYV---TQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + +K K + E ++N T QL Y+ + L + +E + E+
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNA-------LLKQKDE-------EIIALNQKINNA 1035
D + QK+ E + E+ K L K+ D+ E++AL +K +
Sbjct: 662 DTY-QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 1036 QVS-----------YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
Y S + S A +L N++ E+ V KQL ++ E+L+
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 1085 VREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDAN 1126
+E +KE K+ K TF + P+ + S + + N
Sbjct: 781 AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRN 823
Score = 73.3 bits (172), Expect = 6e-12
Identities = 142/672 (21%), Positives = 276/672 (41%), Gaps = 52/672 (7%)
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
EN K+ + Q I++L+ E + KL+ IQEN DL E + + LL +
Sbjct: 136 ENRKIIEAQRKA-IQELQFGNEKVSLKLEEGIQENKDLIK--ENNATRHLCNLLKETCAR 192
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
K + ++ + + + R +Y++ + + + K I EE E+ R + K +
Sbjct: 193 SAEKTK-KYEYERE-ETRQVYMD-LNNNIEK---MITAFEELRVQAENSRLEMHFKLKED 246
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+Q ++ Y + +++ V+ L + + K L + E+++ K NQ LEE
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD--KVNQ--LEEK 302
Query: 863 QNLQ---ISLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTL 917
LQ + S +QH+ + + L S ST+ + L+ + ++T E +T
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
Query: 918 IVQKKK---EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + K + EF T + S + ++ EKN + + L +LQ+ + +E +
Sbjct: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ ++ LE + K + +++T Y + + K+ LK ++E+I L Q
Sbjct: 423 T-KLTNNKEVELEELKKVLGEKETLL--YENK---QFEKIAEELKGTEQELIGLLQ---- 472
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ V D E +L TT + +E++ + +L + K N EL + + KE
Sbjct: 473 ---AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE 529
Query: 1095 L-KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEE 1149
L +ET +T E+ + + E M N+ ++ Q+ +E
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ +E L +++ I +L+ N L +Q+N + K+ +L E
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELE 649
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFE----IAELWKQHLAQREADFQKTEHELRVQ----- 1260
++ E+ + ++ + + E+ K + EA + E + R Q
Sbjct: 650 LESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE 709
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+ A K++ D + E + EQ +SL+ L E L NL+ + V Q
Sbjct: 710 MVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNLKAELLSVKKQ 766
Query: 1320 IEILRSEIEDEK 1331
+EI R E E K
Sbjct: 767 LEIEREEKEKLK 778
Score = 67.3 bits (157), Expect = 4e-10
Identities = 122/615 (19%), Positives = 256/615 (41%), Gaps = 59/615 (9%)
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E++LQE + IE ++EL N E + +++ ++ D ++ N L LL
Sbjct: 129 QKESKLQENRKIIEAQRKAIQELQFGN-EKVSLKLEEGIQENKDLIKEN-NATRHLCNLL 186
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQH 1077
K+ +K + + D + + + T E + + + ++ K+
Sbjct: 187 KETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKED 246
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E++Q L +E +I + ++ + I + E + T + +++ +
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF--LLEESRD---------- 294
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
KV + ++E++ LQ ++ K + E Q TK +LE + L V Q+ +
Sbjct: 295 -----KVNQ----LEEKTKLQSENLKQSIEKQHHLTK--ELEDIKVSLQ-RSVSTQKALE 342
Query: 1198 ---QLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ +K + QL E + + + R++ S V + + L ++ L + +K
Sbjct: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL-EELLRTEQQRLEKN 401
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTMEQVTSLQNKLQDK-EEHLR 1307
E +L++ + K +L + + + EE K++ ++ +NK +K E L+
Sbjct: 402 EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELK 461
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE--NQSYKQMQEQ 1365
++ ++I ++ E+ D ++ DL+TE N+ K +
Sbjct: 462 GTEQ---ELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK-DLKTELENEKLKNTELT 517
Query: 1366 SILN-INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
S N ++ EN +L + + +N+ + + + LK E Q+T
Sbjct: 518 SHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-----EERMLKQIENLQETE--- 569
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY-ETMQKESEIE 1483
TQ +E E VR++L + ++ + E LR K EN N Y E +Q+E++
Sbjct: 570 ---TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR-KQVENKNKYIEELQQENKAL 625
Query: 1484 RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+ K E + +NK EL A ++ T+ Q +E+++I L +E+
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA 685
Query: 1544 QNMVRASSSKIQKHV 1558
+ ++ + K+QK +
Sbjct: 686 K-VIADEAVKLQKEI 699
Score = 54.4 bits (125), Expect = 3e-06
Identities = 113/612 (18%), Positives = 261/612 (42%), Gaps = 64/612 (10%)
Query: 151 IKEKDNALSVLQVKMKIMETTILDLQEKINE-KDQI--IEAKNKATTXXXXXXXXXXXXX 207
I +K+ +S+L +++ E + DL + E +D++ +E K K +
Sbjct: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL 320
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
ED K + + A+E + + + + + E K+ + +EE+NK A F +
Sbjct: 321 TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ---MEESNKARAAHSFVV 377
Query: 268 SLEHSKLA--QEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ + + +EL EQ + Q EE T++ +E+ +
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + E L + N Q + +EL+ GTE + + + + + +
Sbjct: 438 KVLGEKETLLYENKQFEKIAEELK------GTEQELIGLLQAREKEVHDLEIQLTAITTS 491
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ +S+ + + ++K+ E+ + NK+L + ++ +
Sbjct: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
++ + + Q+E+ Q T T+ NE+ V+E+LKQ+ DE+K
Sbjct: 552 KKQEERMLK-QIENLQE----------TETQLRNELEYVREELKQK-RDEVKC------- 592
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHK-LKLK--QMQKTIDNFS-KVSDSNKEIV 558
KL +EE L +++ NK + +++ +K LK K K ++ + KV+ E+
Sbjct: 593 -KLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELE 651
Query: 559 RLTEELHHLSQKV-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAI 616
++ ++ E+E++K + + L + + ++I + K E++ + ++ + +
Sbjct: 652 SAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMV 711
Query: 617 SLLESQKFDLVQELHILQQKYDE-VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+L+E K +YD+ +E++ +++ +S + E S+ +I+ LS K
Sbjct: 712 ALMEKHK-----------HQYDKIIEERDSELGLYKSKE--QEQSSLRASLEIE-LSNLK 757
Query: 676 KELALVIENLKLDKEQLYGTIKDLEND----KEDIMNKLQNYIQENMDLTDKLEK--MSA 729
EL V + L++++E+ ++ + + KE K Q ++ E ++ KL+ + +
Sbjct: 758 AELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPS 817
Query: 730 EKISELLAKINH 741
+ +S ++H
Sbjct: 818 QTVSRNFTSVDH 829
>AY736182-1|AAU86898.1| 1989|Homo sapiens ninein isoform 6 protein.
Length = 1989
Score = 87.8 bits (208), Expect = 3e-16
Identities = 231/1158 (19%), Positives = 477/1158 (41%), Gaps = 120/1158 (10%)
Query: 458 QHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVN--VKDLIEKLKSAEEQITQL 515
Q +EG + E E E K EL E + +K+ +++ K+ +TQ
Sbjct: 834 QSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS--NKEIVRL-TEELHHLSQKVA 572
+ ++ K + + +L Q + + N S+ S + +I+ L + + L ++
Sbjct: 894 REMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHIRELREREE 953
Query: 573 EL-----EEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLV 627
L E+ + +L ++ + + ++ K++ MEN+ + + + ++ ++
Sbjct: 954 VLCQAGASEQLASQRLERLEMEHAQE-RQEMMSKLLAMENIHKATCETA---DRERAEMS 1009
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN--- 684
E+ LQ K E++ + +S LQS C I +E ALS + L+ EN
Sbjct: 1010 TEISRLQSKIKEMQQATSPLSMLQSG--CQVIGEEEVEGD-GALSLLHQGEQLLEENGDV 1066
Query: 685 -LKLDK--EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKIN- 740
L L + EQ + + + +LQ ++ + ++ L++ + E +
Sbjct: 1067 FLSLQRAHEQAVKENVKMATEISRLQQRLQK-LEPGLVMSSCLDEPATEFFGNTAEQTEP 1125
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+Q++ + G+ + DL + + S S + R E I E+ S+E ++
Sbjct: 1126 FLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKI---EESEASVEGFSE 1182
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLM-DHDRVVEKQ---LLEIEHENKELQKKNQ 856
S +E + E Q +L +L +L D DR EK+ L ++ K+L+ +
Sbjct: 1183 LENS--EETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLER 1240
Query: 857 ILLEENQNLQISLSDMQQHYNALVEKAN----RTDLAESESTKYQTQLRDLESNLKRITH 912
I E + ++ D+ + + L E+ R D A + + ++ L+ LK++
Sbjct: 1241 IP-EASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEE 1299
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIE 972
+T + +K ++++IE N ++ + L K EK E V Q ++ ++E
Sbjct: 1300 VTETFL-SLEKSYDEVKIE-NEELNVLVLR---LQGKIEKLQESVVQ-RCDCCLWEASLE 1353
Query: 973 NLNM----NVEELNKMNLELIDK-----HVQKQQTQSPDYTE---QYI-----NEINKLN 1015
NL + N+ +LN+ E + + HV ++ Q Y E Q + +EI L+
Sbjct: 1354 NLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLH 1413
Query: 1016 ALLKQKDEEIIALNQKI---NNAQVSYMSMVSDYESKLAQFT---TKLENMEEEM-QRVS 1068
++ E NQ I N + + +++ +A+ TKL+ + ++ +RV+
Sbjct: 1414 GTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVT 1473
Query: 1069 -----KQLLDSKQHNEELQILVREQDDQIKELKETK--LTFEMNIPKTEGMIISSTIEPM 1121
K +L + EEL+ ++ + E+++ L +E + E I+ + I +
Sbjct: 1474 ILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1533
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETL 1181
+++ +++ Q+ E QE + +Q+ L ++ E K QL+
Sbjct: 1534 NEE-DSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLE 1592
Query: 1182 NTELTGHDVVNQEQINQL----------------KSKLEQLNTENDNLLSTVAELRSSIS 1225
NTEL+ + NQE++ +L S LE+ E NL + + S
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSS 1652
Query: 1226 SAVDQRGFEIAELWKQ-HLAQREADFQKTEHELRVQLSAFE--SKYEQLLDSVQSSTQE- 1281
+ V E++E+ Q H+ Q+E K E E QL S ++Q + SV S ++
Sbjct: 1653 TLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL 1712
Query: 1282 ETNKIVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEI--EDEKVA-FX 1335
K E++ S +KL E + ++++ +Q L+S++ EKV
Sbjct: 1713 LKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLE 1772
Query: 1336 XXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
DLR Q K+ +Q +++++++ S
Sbjct: 1773 DTVQNVNLQMSRMKSDLRVTQQE-KEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN 1831
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
+L H + + ++Q+ +E T+ Q N + +L +++ L
Sbjct: 1832 QQKRLSWDKLDHLMNEEQQLLWQE-NERLQTMVQ------NTKAELTHSREKVRQL---- 1880
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
ES L L H+ + +E E++ L E + E N++V+++N +LE+E
Sbjct: 1881 ESNL----LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMN-SLEQE 1935
Query: 1516 VAKTNEMQTALENQEIEI 1533
+ + L+ +++++
Sbjct: 1936 LETIHLENEGLKKKQVKL 1953
Score = 66.9 bits (156), Expect = 6e-10
Identities = 158/763 (20%), Positives = 326/763 (42%), Gaps = 84/763 (11%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
ED ++ +QE ME + DE K++ ++ R+ +E K+ E +SLE
Sbjct: 1253 EDVSRENDCLQEELRMMETRY-DEALENNKELTAEVFRLQ--DELKKMEEVTETFLSLEK 1309
Query: 272 SKLAQELE-QXXXXXXXXXXXXXXLAKQSIEPSCE--------EKTEIEEKGSLEIANMT 322
S ++E + ++S+ C+ E EIE G++ N T
Sbjct: 1310 SYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQT 1369
Query: 323 --ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTAS 380
E ++ + H+ + +Q N+ LE + + KA G+ ++ R
Sbjct: 1370 LEECVPRVRSVHHVIEECKQENQYLEGNTQLL-EKVKAHEIAWLHGTIQTHQERPR---- 1424
Query: 381 KMKSPWSQLSSETLNQDTDKKI-NKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXX 439
+++ + TL DK ++ IA+LE+ L ++L K + E+ T
Sbjct: 1425 -VQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKL-QELTRK---LKERVTILVKQ- 1478
Query: 440 XXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQE---LNDEIKDV 496
KD L + E + M I + V + E+L+QE L +EI +
Sbjct: 1479 -----KDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTL 1533
Query: 497 NVKDLIEKLK-----SAEEQITQLNDEIDAANKNMIKVKSNHK-----LKLKQMQKTIDN 546
N +D I LK ++E++ Q + + N + K+ N K LK+K Q ++N
Sbjct: 1534 NEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLEN 1593
Query: 547 FSKVSDSNKEIVRLTEELH-HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEM 605
+++S N + +EL+ L++ + + E+E GN L + + + E E+
Sbjct: 1594 -TELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKE--------EL 1644
Query: 606 ENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
E +S LE++ ++ + HI+QQ+ ++D+L + QL C ++ +
Sbjct: 1645 ERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHR---CPDLSD--FQ 1699
Query: 666 EQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE 725
++I ++ + ++L E L E+L + DK + L++ I E
Sbjct: 1700 QKISSVLSYNEKLLKEKEAL---SEELNSCV-----DKLAKSSLLEHRIATMKQEQKSWE 1751
Query: 726 KMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI 785
SA S+L+A + Q+ T ++ ++ + + E K + L + +
Sbjct: 1752 HQSASLKSQLVAS-QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQL 1810
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM--DHDR---VVEKQ 840
+ ++ E G + Q+K+ ++ + D L+N L+ +++R +V+
Sbjct: 1811 QNAGGKSWAPEIATHPSGLHNQQKRLSWDKL----DHLMNEEQQLLWQENERLQTMVQNT 1866
Query: 841 LLEIEHENKELQKKNQILLEENQ---NLQISLSDMQQHYNALVEKANRTDLAESESTKYQ 897
E+ H +++++ LL ++Q N +++ +Q +L + ++ +S + +
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKV 1926
Query: 898 TQLRDLESNLKRITHEHQTLIVQKKKEIE-DLEIEFNTQIESA 939
+Q+ LE L+ I E++ L KKK+++ D ++ N+ + S+
Sbjct: 1927 SQMNSLEQELETIHLENEGL---KKKQVKLDEQLMENSVVGSS 1966
Score = 62.1 bits (144), Expect = 2e-08
Identities = 212/1116 (18%), Positives = 446/1116 (39%), Gaps = 79/1116 (7%)
Query: 467 HVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNM 526
H + + K+ E+ K+ + +K+ K+ + L+ A +Q +L EI+ A
Sbjct: 408 HAAIERRNEYNLRKLDEEYKERIA-ALKNELRKEREQILQQAGKQRLELEQEIEKAKTEE 466
Query: 527 IKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLV 586
++ L LK+ + + + ++ E LT +L + V L E+ G+L
Sbjct: 467 NYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENV--LAEKFGDL----- 519
Query: 587 DYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQEL--HILQQKYDEVEDKL 644
D S + +++ +M N E + + +L+ Q +L EL + Q + + K
Sbjct: 520 DPSSAEFFLQE--ERLTQMRNEYERQCR---VLQDQVDELQSELEEYRAQGRVFRLPLKN 574
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ +++++ E + E+ + L+ S E LVIE + KEQ + I L + E
Sbjct: 575 SPSEEVEANSGGIEPEHGLGSEECNPLNMS-IEAELVIEQM---KEQHHRDICCLRLELE 630
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
D K+++Y ++ +D T K + E + + H + +I A++Q + +
Sbjct: 631 D---KVRHY-EKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVL 686
Query: 765 ENIESELS-----KYKSRICRLEESIAVMEDR---RYSLERKA---DQLGSYLQEKQKAY 813
+ E + + K +LEE ++++ ++ +E KA S+ +E++
Sbjct: 687 KEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQ 746
Query: 814 SEYTIQED--ELVNRLAVLMDHD--RVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
S +E L L +VEK LE E KEL +K+Q L+E + +
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE---KM 803
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+E ++D + + + ++ L+ LE R E + L Q+++E E
Sbjct: 804 ETECNRRTTQIEAQFQSD-CQKVTERCESALQSLEG---RYRQELKDLQEQQREEKSQWE 859
Query: 930 IEFNTQIESAIRDKKVLNE--KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
E + + +++L E K EK V E ++ E K E+LN V E ++ +
Sbjct: 860 FEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLE-KTYKEHLNSMVVERQQLLQD 918
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
L D +TQ ++Q + + L++++E + A + ++
Sbjct: 919 LEDLR-NVSETQQSLLSDQILELKSSHIRELREREEVLCQAGASEQLASQRLERLEMEHA 977
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIP 1107
+ + +KL M E + + + + D + E+ + +IKE+++ M
Sbjct: 978 QERQEMMSKLLAM-ENIHKATCETAD--RERAEMSTEISRLQSKIKEMQQATSPLSM--- 1031
Query: 1108 KTEGMIISSTIEPMSDDANNV--DXXXXXXXXXXXXLKVQE-EEEFIQERSVLQEQSAKL 1164
G + E D A ++ L +Q E+ ++E + + ++L
Sbjct: 1032 LQSGCQVIGEEEVEGDGALSLLHQGEQLLEENGDVFLSLQRAHEQAVKENVKMATEISRL 1091
Query: 1165 NTELQECYTKIIQLETLN---TELTGHDVVNQEQINQLKSKLEQLNTENDNLLS-----T 1216
LQ+ ++ L+ TE G+ E Q + ++LS
Sbjct: 1092 QQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDE 1151
Query: 1217 VAELRSSISSAVDQRGFEI--AELWKQHLAQRE-ADFQKTEH-ELRVQLSAFESKYEQLL 1272
V +L S+ +S+V ++ +I +E + ++ E ++ +TE EL+ Q+S + + L
Sbjct: 1152 VRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLC 1211
Query: 1273 DSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKV 1332
+++++ + + + + L+ E + Y DV + + L+ E+ +
Sbjct: 1212 ADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMET 1271
Query: 1333 AFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXX 1392
+ L+ E + +++ E + L++ + ++K +
Sbjct: 1272 RYDEALENNKELTAEVFR-LQDELKKMEEVTE-TFLSLEKSYDEVKIENEELNVLVLRLQ 1329
Query: 1393 XRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLT 1452
++ + V++ L ++ + E + Q N E ++ IE+
Sbjct: 1330 GKIEKLQESVVQRC-DCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECK 1388
Query: 1453 YEK---ESELAIL-RLKMHENANHYETMQKESEIERV--KLIEELNVKITESVSLNKQVA 1506
E E +L ++K HE A + T+Q E RV ++I E N + + Q
Sbjct: 1389 QENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQ 1448
Query: 1507 ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
LE E K E+ L+ + +V D +++
Sbjct: 1449 ATIAELELEKTKLQELTRKLKERVTILVKQKDVLSH 1484
Score = 48.8 bits (111), Expect = 2e-04
Identities = 104/493 (21%), Positives = 209/493 (42%), Gaps = 51/493 (10%)
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+ LLE + ++K + L++ + L+ S++ ++A +E+ N +L + + +Y+
Sbjct: 370 RHLLERVDQVVREKEKLRSDLDKAEKLKSSMASEVDDHHAAIERRNEYNLRKLDE-EYKE 428
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
++ L++ L++ + +++ E+E EIE E+ IRD+ L+ K +E
Sbjct: 429 RIAALKNELRKEREQILQQAGKQRLELEQ-EIEKAKTEENYIRDRLALSLKENSRLENEL 487
Query: 959 QLEAQ-LQEYKNNIENLNMNVE--------ELNKMNLELIDKHVQKQQTQSPDYTEQ--- 1006
A+ L EY+N L N+E +L+ + E + + Q ++ +Y Q
Sbjct: 488 LENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN-EYERQCRV 546
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNA---QVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+++++L + L++ + + N+ +V S + E L NM E
Sbjct: 547 LQDQVDELQSELEEYRAQGRVFRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIE 606
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQI----KELKETKLTFEM---NIPK---TEGMI 1113
+ V +Q+ +QH+ ++ L E +D++ K+L ET ++ + N+ + E
Sbjct: 607 AELVIEQM--KEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT 664
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQ---- 1169
+ I + ++ + + EEE Q + L+E+ L +L+
Sbjct: 665 LEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHE 724
Query: 1170 -ECYTKIIQLE-TLNTELTG--HDVVNQEQINQLKSKLEQLNTENDNLL---STVA--EL 1220
E ++ Q + + E G +E++ L +LEQ + E L T+ EL
Sbjct: 725 MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEEL 784
Query: 1221 RSSISSAVD---QRGFEIAEL-----WKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
R + Q G E E Q AQ ++D QK L + E +Y Q L
Sbjct: 785 RKELLEKHQRELQEGREKMETECNRRTTQIEAQFQSDCQKVTERCESALQSLEGRYRQEL 844
Query: 1273 DSVQSSTQEETNK 1285
+Q +EE ++
Sbjct: 845 KDLQEQQREEKSQ 857
Score = 38.7 bits (86), Expect = 0.17
Identities = 62/370 (16%), Positives = 147/370 (39%), Gaps = 36/370 (9%)
Query: 1189 DVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREA 1248
D V +E+ +L+S L++ ++ S V + ++I + ++ E +K+ +A +
Sbjct: 377 DQVVREK-EKLRSDLDKAEKLKSSMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKN 435
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLR 1307
+ +K ++ Q + EQ ++ ++ +++ +++++ + L+N+L + E L
Sbjct: 436 ELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLA 495
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
+Y ++ N+++ + EK +R E + ++ + +
Sbjct: 496 ----EYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQV 551
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ E + + +A + +E H L ++
Sbjct: 552 DELQSELEEYRAQGRVFRLPLKNSPSEEVEANSGGIEPEHGLGSEEC------------- 598
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
N +E E IE + + ++ LRL++ + HYE E+ + K
Sbjct: 599 --------NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 1488 IEELNVK-ITESVSLNKQVAELNKALEE-----EVAKTNEMQTALENQEIE---IVTLND 1538
E + + E+ +L KQ+++L + E V K + ++E + V L +
Sbjct: 651 QENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEE 710
Query: 1539 EITNLQNMVR 1548
E T+LQ +R
Sbjct: 711 EKTHLQEKLR 720
>AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex protein
1 protein.
Length = 976
Score = 87.8 bits (208), Expect = 3e-16
Identities = 130/588 (22%), Positives = 275/588 (46%), Gaps = 74/588 (12%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVN------------VKDLIEKLKSAEEQITQLNDEID 520
ED +I ++++ K+E+ND+ K V+ +KDL L+ + +++ QL ++
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
Query: 521 AANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
++N+ + ++ H L K+++ + + + K L E+L ++ + +L EEK
Sbjct: 305 LQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQK---ALEEDLQIATKTICQLTEEK- 359
Query: 580 NLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + + R S V + + +E L T + + E Q L E LQ+
Sbjct: 360 --ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME---LQK 414
Query: 636 KYDEVED--KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K E+E+ KL + +++ + E+K V E+ + L K+ + E LK +++L
Sbjct: 415 KSSELEEMTKLTNNKEVELE----ELKKVLGEK--ETLLYENKQFEKIAEELKGTEQELI 468
Query: 694 GTIKDLENDKEDIMNKL-------QNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
G ++ E + D+ +L Q Y +E DL +LE K +EL + N ++
Sbjct: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLEN 527
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
K TQ + + L ++N + +++ K + R+ + I +++ L + + +
Sbjct: 528 KELTQ-----ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
L++K+ + +E N L +++ K + E++ ENK L+KK ++
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENK---NKYIEELQQENKALKKKGTA-----ESK 634
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q+++ +++ + L ++ + E T YQ ++ D K+I+ E+ V+K K I
Sbjct: 635 QLNVYEIKVNKLELELESAKQKFGEITDT-YQKEIED-----KKISEENLLEEVEKAKVI 688
Query: 926 ED----LEIEFNTQIESAIRDKKVLNEKYEKNIE-YVTQLEAQLQEYKNNIE---NLNMN 977
D L+ E + + + I + L EK++ + + + +++L YK+ + +L +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRAS 748
Query: 978 VE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+E EL+ + EL+ V+KQ + E+ E + A LK+K ++
Sbjct: 749 LEIELSNLKAELLS--VKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
Score = 79.8 bits (188), Expect = 7e-14
Identities = 148/703 (21%), Positives = 288/703 (40%), Gaps = 66/703 (9%)
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKL-- 537
Q++ K + N +I + K I++L+ E+++ +E NK++IK + H L
Sbjct: 129 QKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK-VAELEE-----EKGNLQLHLV---DY 588
+ ++ + K +E ++ +L++ +K + EE E L++H DY
Sbjct: 188 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDY 247
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ + +E + K++ + E L I+ E++ DL L + K +++E+K +
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK----T 303
Query: 649 QLQSDQVCSEI-KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+LQS+ + I K HL ++++ + S + + L+ D + TI L +KE M
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
Query: 708 NKLQNYIQENMDLTDKLEKM--SAEKI--SELLAKINHEEQSKIQTQF--GIDAKIQERD 761
+ + + + E S E++ +E +E+Q KI T ++++E
Sbjct: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYS-----LERKADQLGSYLQEKQKAYSEY 816
N E EL + K + E+ + E++++ L+ +L LQ ++K +
Sbjct: 424 KLTNNKEVELEELKKVLG--EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
IQ + + ++ +L + +N EL L EN+ L SDM
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFN 933
E N E K L++ E+ L+ + + QK+ E++ D E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 934 TQIESAIRDK-KVLNEKYEKNIEYV---TQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + +K K + E ++N T QL Y+ + L + +E + E+
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNA-------LLKQKDE-------EIIALNQKINNA 1035
D + QK+ E + E+ K L K+ D+ E++AL +K +
Sbjct: 662 DTY-QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 1036 QVS-----------YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
Y S + S A +L N++ E+ V KQL ++ E+L+
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 1085 VREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDAN 1126
+E +KE K+ K TF + P+ + S + + N
Sbjct: 781 AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRN 823
Score = 73.3 bits (172), Expect = 6e-12
Identities = 142/672 (21%), Positives = 276/672 (41%), Gaps = 52/672 (7%)
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
EN K+ + Q I++L+ E + KL+ IQEN DL E + + LL +
Sbjct: 136 ENRKIIEAQRKA-IQELQFGNEKVSLKLEEGIQENKDLIK--ENNATRHLCNLLKETCAR 192
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
K + ++ + + + R +Y++ + + + K I EE E+ R + K +
Sbjct: 193 SAEKTK-KYEYERE-ETRQVYMD-LNNNIEK---MITAFEELRVQAENSRLEMHFKLKED 246
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+Q ++ Y + +++ V+ L + + K L + E+++ K NQ LEE
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD--KVNQ--LEEK 302
Query: 863 QNLQ---ISLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTL 917
LQ + S +QH+ + + L S ST+ + L+ + ++T E +T
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
Query: 918 IVQKKK---EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + K + EF T + S + ++ EKN + + L +LQ+ + +E +
Sbjct: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ ++ LE + K + +++T Y + + K+ LK ++E+I L Q
Sbjct: 423 T-KLTNNKEVELEELKKVLGEKETLL--YENK---QFEKIAEELKGTEQELIGLLQ---- 472
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ V D E +L TT + +E++ + +L + K N EL + + KE
Sbjct: 473 ---AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE 529
Query: 1095 L-KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEE 1149
L +ET +T E+ + + E M N+ ++ Q+ +E
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ +E L +++ I +L+ N L +Q+N + K+ +L E
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELE 649
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFE----IAELWKQHLAQREADFQKTEHELRVQ----- 1260
++ E+ + ++ + + E+ K + EA + E + R Q
Sbjct: 650 LESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE 709
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+ A K++ D + E + EQ +SL+ L E L NL+ + V Q
Sbjct: 710 MVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNLKAELLSVKKQ 766
Query: 1320 IEILRSEIEDEK 1331
+EI R E E K
Sbjct: 767 LEIEREEKEKLK 778
Score = 67.3 bits (157), Expect = 4e-10
Identities = 122/615 (19%), Positives = 256/615 (41%), Gaps = 59/615 (9%)
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E++LQE + IE ++EL N E + +++ ++ D ++ N L LL
Sbjct: 129 QKESKLQENRKIIEAQRKAIQELQFGN-EKVSLKLEEGIQENKDLIKEN-NATRHLCNLL 186
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQH 1077
K+ +K + + D + + + T E + + + ++ K+
Sbjct: 187 KETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKED 246
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E++Q L +E +I + ++ + I + E + T + +++ +
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF--LLEESRD---------- 294
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
KV + ++E++ LQ ++ K + E Q TK +LE + L V Q+ +
Sbjct: 295 -----KVNQ----LEEKTKLQSENLKQSIEKQHHLTK--ELEDIKVSLQ-RSVSTQKALE 342
Query: 1198 ---QLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ +K + QL E + + + R++ S V + + L ++ L + +K
Sbjct: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL-EELLRTEQQRLEKN 401
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTMEQVTSLQNKLQDK-EEHLR 1307
E +L++ + K +L + + + EE K++ ++ +NK +K E L+
Sbjct: 402 EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELK 461
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE--NQSYKQMQEQ 1365
++ ++I ++ E+ D ++ DL+TE N+ K +
Sbjct: 462 GTEQ---ELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK-DLKTELENEKLKNTELT 517
Query: 1366 SILN-INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
S N ++ EN +L + + +N+ + + + LK E Q+T
Sbjct: 518 SHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-----EERMLKQIENLQETE--- 569
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY-ETMQKESEIE 1483
TQ +E E VR++L + ++ + E LR K EN N Y E +Q+E++
Sbjct: 570 ---TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR-KQVENKNKYIEELQQENKAL 625
Query: 1484 RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+ K E + +NK EL A ++ T+ Q +E+++I L +E+
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA 685
Query: 1544 QNMVRASSSKIQKHV 1558
+ ++ + K+QK +
Sbjct: 686 K-VIADEAVKLQKEI 699
Score = 54.4 bits (125), Expect = 3e-06
Identities = 113/612 (18%), Positives = 261/612 (42%), Gaps = 64/612 (10%)
Query: 151 IKEKDNALSVLQVKMKIMETTILDLQEKINE-KDQI--IEAKNKATTXXXXXXXXXXXXX 207
I +K+ +S+L +++ E + DL + E +D++ +E K K +
Sbjct: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL 320
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
ED K + + A+E + + + + + E K+ + +EE+NK A F +
Sbjct: 321 TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ---MEESNKARAAHSFVV 377
Query: 268 SLEHSKLA--QEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ + + +EL EQ + Q EE T++ +E+ +
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + E L + N Q + +EL+ GTE + + + + + +
Sbjct: 438 KVLGEKETLLYENKQFEKIAEELK------GTEQELIGLLQAREKEVHDLEIQLTAITTS 491
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ +S+ + + ++K+ E+ + NK+L + ++ +
Sbjct: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
++ + + Q+E+ Q T T+ NE+ V+E+LKQ+ DE+K
Sbjct: 552 KKQEERMLK-QIENLQE----------TETQLRNELEYVREELKQK-RDEVKC------- 592
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHK-LKLK--QMQKTIDNFS-KVSDSNKEIV 558
KL +EE L +++ NK + +++ +K LK K K ++ + KV+ E+
Sbjct: 593 -KLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELE 651
Query: 559 RLTEELHHLSQKV-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAI 616
++ ++ E+E++K + + L + + ++I + K E++ + ++ + +
Sbjct: 652 SAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMV 711
Query: 617 SLLESQKFDLVQELHILQQKYDE-VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+L+E K +YD+ +E++ +++ +S + E S+ +I+ LS K
Sbjct: 712 ALMEKHK-----------HQYDKIIEERDSELGLYKSKE--QEQSSLRASLEIE-LSNLK 757
Query: 676 KELALVIENLKLDKEQLYGTIKDLEND----KEDIMNKLQNYIQENMDLTDKLEK--MSA 729
EL V + L++++E+ ++ + + KE K Q ++ E ++ KL+ + +
Sbjct: 758 AELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPS 817
Query: 730 EKISELLAKINH 741
+ +S ++H
Sbjct: 818 QTVSRNFTSVDH 829
>AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex protein
1 protein.
Length = 976
Score = 87.8 bits (208), Expect = 3e-16
Identities = 130/588 (22%), Positives = 275/588 (46%), Gaps = 74/588 (12%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVN------------VKDLIEKLKSAEEQITQLNDEID 520
ED +I ++++ K+E+ND+ K V+ +KDL L+ + +++ QL ++
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
Query: 521 AANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
++N+ + ++ H L K+++ + + + K L E+L ++ + +L EEK
Sbjct: 305 LQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQK---ALEEDLQIATKTICQLTEEK- 359
Query: 580 NLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + + R S V + + +E L T + + E Q L E LQ+
Sbjct: 360 --ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME---LQK 414
Query: 636 KYDEVED--KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K E+E+ KL + +++ + E+K V E+ + L K+ + E LK +++L
Sbjct: 415 KSSELEEMTKLTNNKEVELE----ELKKVLGEK--ETLLYENKQFEKIAEELKGTEQELI 468
Query: 694 GTIKDLENDKEDIMNKL-------QNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
G ++ E + D+ +L Q Y +E DL +LE K +EL + N ++
Sbjct: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLEN 527
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
K TQ + + L ++N + +++ K + R+ + I +++ L + + +
Sbjct: 528 KELTQ-----ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
L++K+ + +E N L +++ K + E++ ENK L+KK ++
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENK---NKYIEELQQENKALKKKGTA-----ESK 634
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q+++ +++ + L ++ + E T YQ ++ D K+I+ E+ V+K K I
Sbjct: 635 QLNVYEIKVNKLELELESAKQKFGEITDT-YQKEIED-----KKISEENLLEEVEKAKVI 688
Query: 926 ED----LEIEFNTQIESAIRDKKVLNEKYEKNIE-YVTQLEAQLQEYKNNIE---NLNMN 977
D L+ E + + + I + L EK++ + + + +++L YK+ + +L +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRAS 748
Query: 978 VE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+E EL+ + EL+ V+KQ + E+ E + A LK+K ++
Sbjct: 749 LEIELSNLKAELLS--VKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
Score = 79.8 bits (188), Expect = 7e-14
Identities = 148/703 (21%), Positives = 288/703 (40%), Gaps = 66/703 (9%)
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKL-- 537
Q++ K + N +I + K I++L+ E+++ +E NK++IK + H L
Sbjct: 129 QKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK-VAELEE-----EKGNLQLHLV---DY 588
+ ++ + K +E ++ +L++ +K + EE E L++H DY
Sbjct: 188 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDY 247
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ + +E + K++ + E L I+ E++ DL L + K +++E+K +
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK----T 303
Query: 649 QLQSDQVCSEI-KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+LQS+ + I K HL ++++ + S + + L+ D + TI L +KE M
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
Query: 708 NKLQNYIQENMDLTDKLEKM--SAEKI--SELLAKINHEEQSKIQTQF--GIDAKIQERD 761
+ + + + E S E++ +E +E+Q KI T ++++E
Sbjct: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYS-----LERKADQLGSYLQEKQKAYSEY 816
N E EL + K + E+ + E++++ L+ +L LQ ++K +
Sbjct: 424 KLTNNKEVELEELKKVLG--EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
IQ + + ++ +L + +N EL L EN+ L SDM
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFN 933
E N E K L++ E+ L+ + + QK+ E++ D E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 934 TQIESAIRDK-KVLNEKYEKNIEYV---TQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + +K K + E ++N T QL Y+ + L + +E + E+
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNA-------LLKQKDE-------EIIALNQKINNA 1035
D + QK+ E + E+ K L K+ D+ E++AL +K +
Sbjct: 662 DTY-QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 1036 QVS-----------YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
Y S + S A +L N++ E+ V KQL ++ E+L+
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 1085 VREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDAN 1126
+E +KE K+ K TF + P+ + S + + N
Sbjct: 781 AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRN 823
Score = 73.3 bits (172), Expect = 6e-12
Identities = 142/672 (21%), Positives = 276/672 (41%), Gaps = 52/672 (7%)
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
EN K+ + Q I++L+ E + KL+ IQEN DL E + + LL +
Sbjct: 136 ENRKIIEAQRKA-IQELQFGNEKVSLKLEEGIQENKDLIK--ENNATRHLCNLLKETCAR 192
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
K + ++ + + + R +Y++ + + + K I EE E+ R + K +
Sbjct: 193 SAEKTK-KYEYERE-ETRQVYMD-LNNNIEK---MITAFEELRVQAENSRLEMHFKLKED 246
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+Q ++ Y + +++ V+ L + + K L + E+++ K NQ LEE
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD--KVNQ--LEEK 302
Query: 863 QNLQ---ISLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTL 917
LQ + S +QH+ + + L S ST+ + L+ + ++T E +T
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
Query: 918 IVQKKK---EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + K + EF T + S + ++ EKN + + L +LQ+ + +E +
Sbjct: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ ++ LE + K + +++T Y + + K+ LK ++E+I L Q
Sbjct: 423 T-KLTNNKEVELEELKKVLGEKETLL--YENK---QFEKIAEELKGTEQELIGLLQ---- 472
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ V D E +L TT + +E++ + +L + K N EL + + KE
Sbjct: 473 ---AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE 529
Query: 1095 L-KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEE 1149
L +ET +T E+ + + E M N+ ++ Q+ +E
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ +E L +++ I +L+ N L +Q+N + K+ +L E
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELE 649
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFE----IAELWKQHLAQREADFQKTEHELRVQ----- 1260
++ E+ + ++ + + E+ K + EA + E + R Q
Sbjct: 650 LESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE 709
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+ A K++ D + E + EQ +SL+ L E L NL+ + V Q
Sbjct: 710 MVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNLKAELLSVKKQ 766
Query: 1320 IEILRSEIEDEK 1331
+EI R E E K
Sbjct: 767 LEIEREEKEKLK 778
Score = 67.3 bits (157), Expect = 4e-10
Identities = 122/615 (19%), Positives = 256/615 (41%), Gaps = 59/615 (9%)
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E++LQE + IE ++EL N E + +++ ++ D ++ N L LL
Sbjct: 129 QKESKLQENRKIIEAQRKAIQELQFGN-EKVSLKLEEGIQENKDLIKEN-NATRHLCNLL 186
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQH 1077
K+ +K + + D + + + T E + + + ++ K+
Sbjct: 187 KETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKED 246
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E++Q L +E +I + ++ + I + E + T + +++ +
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF--LLEESRD---------- 294
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
KV + ++E++ LQ ++ K + E Q TK +LE + L V Q+ +
Sbjct: 295 -----KVNQ----LEEKTKLQSENLKQSIEKQHHLTK--ELEDIKVSLQ-RSVSTQKALE 342
Query: 1198 ---QLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ +K + QL E + + + R++ S V + + L ++ L + +K
Sbjct: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL-EELLRTEQQRLEKN 401
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTMEQVTSLQNKLQDK-EEHLR 1307
E +L++ + K +L + + + EE K++ ++ +NK +K E L+
Sbjct: 402 EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELK 461
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE--NQSYKQMQEQ 1365
++ ++I ++ E+ D ++ DL+TE N+ K +
Sbjct: 462 GTEQ---ELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK-DLKTELENEKLKNTELT 517
Query: 1366 SILN-INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
S N ++ EN +L + + +N+ + + + LK E Q+T
Sbjct: 518 SHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-----EERMLKQIENLQETE--- 569
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY-ETMQKESEIE 1483
TQ +E E VR++L + ++ + E LR K EN N Y E +Q+E++
Sbjct: 570 ---TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR-KQVENKNKYIEELQQENKAL 625
Query: 1484 RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+ K E + +NK EL A ++ T+ Q +E+++I L +E+
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA 685
Query: 1544 QNMVRASSSKIQKHV 1558
+ ++ + K+QK +
Sbjct: 686 K-VIADEAVKLQKEI 699
Score = 54.4 bits (125), Expect = 3e-06
Identities = 113/612 (18%), Positives = 261/612 (42%), Gaps = 64/612 (10%)
Query: 151 IKEKDNALSVLQVKMKIMETTILDLQEKINE-KDQI--IEAKNKATTXXXXXXXXXXXXX 207
I +K+ +S+L +++ E + DL + E +D++ +E K K +
Sbjct: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL 320
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
ED K + + A+E + + + + + E K+ + +EE+NK A F +
Sbjct: 321 TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ---MEESNKARAAHSFVV 377
Query: 268 SLEHSKLA--QEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ + + +EL EQ + Q EE T++ +E+ +
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + E L + N Q + +EL+ GTE + + + + + +
Sbjct: 438 KVLGEKETLLYENKQFEKIAEELK------GTEQELIGLLQAREKEVHDLEIQLTAITTS 491
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ +S+ + + ++K+ E+ + NK+L + ++ +
Sbjct: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
++ + + Q+E+ Q T T+ NE+ V+E+LKQ+ DE+K
Sbjct: 552 KKQEERMLK-QIENLQE----------TETQLRNELEYVREELKQK-RDEVKC------- 592
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHK-LKLK--QMQKTIDNFS-KVSDSNKEIV 558
KL +EE L +++ NK + +++ +K LK K K ++ + KV+ E+
Sbjct: 593 -KLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELE 651
Query: 559 RLTEELHHLSQKV-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRL-KAI 616
++ ++ E+E++K + + L + + ++I + K E++ + ++ + +
Sbjct: 652 SAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMV 711
Query: 617 SLLESQKFDLVQELHILQQKYDE-VEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+L+E K +YD+ +E++ +++ +S + E S+ +I+ LS K
Sbjct: 712 ALMEKHK-----------HQYDKIIEERDSELGLYKSKE--QEQSSLRASLEIE-LSNLK 757
Query: 676 KELALVIENLKLDKEQLYGTIKDLEND----KEDIMNKLQNYIQENMDLTDKLEK--MSA 729
EL V + L++++E+ ++ + + KE K Q ++ E ++ KL+ + +
Sbjct: 758 AELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPS 817
Query: 730 EKISELLAKINH 741
+ +S ++H
Sbjct: 818 QTVSRNFTSVDH 829
>AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant 1
protein.
Length = 2046
Score = 87.8 bits (208), Expect = 3e-16
Identities = 148/756 (19%), Positives = 330/756 (43%), Gaps = 72/756 (9%)
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEK 578
I KN+ K K ++ T+ +V S ++I EE+ L K+ + E+E+
Sbjct: 1210 IRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKER 1269
Query: 579 GNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD 638
L+L+ D R+ S++ ++ + N E+ + + +++ +E+ LQ +YD
Sbjct: 1270 NELRLN-SDRLESRI--SELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYD 1326
Query: 639 E-------VEDKLADISQLQSDQVCSEIKS--------VHLEEQIDALSASKKELALVIE 683
+E ++ + +++ ++ E+ + E + + +KK L E
Sbjct: 1327 ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1386
Query: 684 N-LKLD---KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+ L+++ K QL + DL+ D E+ LQ ++ LT +L+ + +
Sbjct: 1387 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR-- 1444
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESE-LSKYKSRICRLEESIAVMEDRRYSLERK 798
NHE + K Q +F + + E ++ E L + K + L E+ ++ + LE K
Sbjct: 1445 NHELEKK-QRRFDSELSQAHEEAQREKLQREKLQREKDML--LAEAFSL----KQQLEEK 1497
Query: 799 ADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ + Q+ + + + QE + LA + R +E ++ + E E E
Sbjct: 1498 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1557
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
Q+L + L++ + M+Q ++ E +R + E Q +L+ +E L+ +E +
Sbjct: 1558 QMLEQAKLRLEMEMERMRQTHSK--EMESRDEEVEEARQSCQKKLKQMEVQLEE-EYEDK 1614
Query: 916 TLIVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNN---- 970
++++K+E+E + Q+ +K L + ++ + + L KN+
Sbjct: 1615 QKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSK 1674
Query: 971 --IENLNMNVEE-----------LNKMNLELIDKHVQ-----KQQTQSPDYTEQYINEIN 1012
I L +EE M +E+ D H+Q K +T + + E N
Sbjct: 1675 REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN 1734
Query: 1013 KLNALLKQKDEEIIAL--NQKINNAQVSY-MSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ L++ E++ L K AQ S ++ ++D +++L + + + ++E++Q +
Sbjct: 1735 EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1794
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFE-MNIPKTEGMI--ISSTIEPMSDDAN 1126
Q+ +Q + + LV Q+ +I+EL ET+L FE + + E + + +E ++++ +
Sbjct: 1795 QVEFLEQSMVD-KSLVSRQEAKIREL-ETRLEFERTQVKRLESLASRLKENMEKLTEERD 1852
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
L+ ++ + +E L + A+ + + E + LE N L
Sbjct: 1853 QRIAAENREKEQNKRLQ-RQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ 1911
Query: 1187 GHDVVNQEQINQLKSKL--EQLNTENDNLLSTVAEL 1220
+ ++I L++ + E + EN++L++++ ++
Sbjct: 1912 ADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDM 1947
Score = 87.8 bits (208), Expect = 3e-16
Identities = 152/763 (19%), Positives = 319/763 (41%), Gaps = 61/763 (7%)
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV-EKANRTDLAESESTKY 896
E+Q+ + E ++L+ K + +E L+++ ++ + L E + + ES S
Sbjct: 1245 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 1304
Query: 897 QTQLRD---LESNLKRITHEHQTLIVQKK-KEIEDLEIEF--NTQIESAIRDKKVLNE-- 948
+ + E +K + ++ L Q + E+E +E +I + D E
Sbjct: 1305 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 1364
Query: 949 -KYEKNIEYVTQLEAQLQ-EYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
KYE+ + V + +LQ E+++ +E VE+ NK LE +Q +S +Q
Sbjct: 1365 LKYERAVREVDFTKKRLQQEFEDKLE-----VEQQNKRQLERRLGDLQADSEESQRALQQ 1419
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ +L A L+ D ++ Q++ N ++ E K +F ++L EE QR
Sbjct: 1420 LKKKCQRLTAELQ--DTKLHLEGQQVRNHEL---------EKKQRRFDSELSQAHEEAQR 1468
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
Q ++ + L Q++E F + E + + + D+A+
Sbjct: 1469 EKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEAS 1528
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERS----VLQEQSAKLNTELQEC-YTKIIQLETL 1181
KV+++EE + E++ +L++ +L E++ T ++E+
Sbjct: 1529 ---LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1585
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR---SSISSAVDQRGFEIAEL 1238
+ E+ Q+++ Q++ +LE+ + +L EL +++S V++R FE +
Sbjct: 1586 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1645
Query: 1239 WKQHLAQREADFQKTEHELRVQLSAFESKYE--QLLDSVQSS-----TQEETNKIVTMEQ 1291
++ L + +A + L ++ SK E QL + ++ S + K + +E
Sbjct: 1646 LRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE- 1704
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L ++ D + L+E+ + + + +++ +E+++ D
Sbjct: 1705 IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD 1764
Query: 1352 LRTENQSYKQMQEQSILNIN-EENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
L N Q++E + +E Q +S V+ EAK+ EL +LE
Sbjct: 1765 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1824
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENA 1470
+ +++ ++ L + ++ R Q + E R EKE + R
Sbjct: 1825 FERTQV-KRLESLASRLKENMEKLTEERDQRIAAENR------EKEQNKRLQRQLRDTKE 1877
Query: 1471 NHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
E +KE+E R K E++++ E+ + + Q A+L A + + ++Q A+E+ E
Sbjct: 1878 EMGELARKEAEASRKKHELEMDLESLEAANQSLQ-ADLKLAFK----RIGDLQAAIED-E 1931
Query: 1531 IEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD 1573
+E D I +LQ+MV K + + SD ++++D
Sbjct: 1932 MESDENEDLINSLQDMV-TKYQKRKNKLEGDSDVDSELEDRVD 1973
Score = 78.6 bits (185), Expect = 2e-13
Identities = 142/726 (19%), Positives = 297/726 (40%), Gaps = 67/726 (9%)
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIE 683
F V+ L +Q +++ +K +I QL+S +E + L D L + EL +
Sbjct: 1232 FTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELT 1291
Query: 684 NLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD-LTDKLEKMSAEKISELLAKINHE 742
+ + E + D E + K +Q D L ++E M E + L +
Sbjct: 1292 DERNTGESA-SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA--- 1347
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR-LEESIAVMEDRRYSLERKADQ 801
++I + D E L E E+ K R+ + E+ + V + + LER+
Sbjct: 1348 --AEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGD 1405
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L + +E Q+A + + L L H + + E+E + + + EE
Sbjct: 1406 LQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1465
Query: 862 NQNLQISLSDMQQHYNALVEKA----NRTDLAESESTKYQTQLRDLESNLKRITHEH--- 914
Q ++ +Q+ + L+ +A + + + + + ++ LE+ L+ I+ +
Sbjct: 1466 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1525
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + + KK++ DLE + Q E + + + ++E Q + +E+
Sbjct: 1526 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1585
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ VEE + QK+ Q E+ + K+ ++ + ++ L+ ++N
Sbjct: 1586 DEEVEEAR--------QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1637
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILV--REQDDQI 1092
D+ES+ + + ++++R L D++ + L+ + + Q+
Sbjct: 1638 ---------RDFESE--------KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1680
Query: 1093 K-ELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
K +L+E++ T + + M + IE + + D ++Q E+ I
Sbjct: 1681 KNQLEESEFTCAAAVKARKAMEVE--IEDLHLQID--DIAKAKTALEEQLSRLQREKNEI 1736
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
Q R L+E +N +++ + Q D+ QIN L+++LE+ N E
Sbjct: 1737 QNR--LEEDQEDMNELMKKHKAAVAQ--------ASRDLA---QINDLQAQLEEANKEKQ 1783
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQL 1271
L + L+S + ++Q + + + +Q RE + + E E R Q+ ES +L
Sbjct: 1784 ELQEKLQALQSQV-EFLEQSMVDKSLVSRQEAKIRELE-TRLEFE-RTQVKRLESLASRL 1840
Query: 1272 LDSVQSSTQEETNKIVT----MEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
++++ T+E +I EQ LQ +L+D +E + L K A+ + L ++
Sbjct: 1841 KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL 1900
Query: 1328 EDEKVA 1333
E + A
Sbjct: 1901 ESLEAA 1906
Score = 54.8 bits (126), Expect = 2e-06
Identities = 101/497 (20%), Positives = 220/497 (44%), Gaps = 53/497 (10%)
Query: 307 KTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLAT--------MGTESKA 358
+ E+++ S E + L K + L L +++ +EL+ + T + E +
Sbjct: 1512 EAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEM 1571
Query: 359 VSSPSKKGSPLISRKSGRNTASKM-KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL 417
+ SR A + + Q+ + + DK+ E +LE + +L
Sbjct: 1572 ERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATL 1631
Query: 418 NKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPS---LIHVGTNTED 474
+ D V++ SEK D AQL L+H ++ PS + + E+
Sbjct: 1632 S-DQVNRRDFESEKRLRKDLKRTKALLAD---AQLMLDHLKN-SAPSKREIAQLKNQLEE 1686
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVK-DLIEKLKSA-EEQITQLNDE-------IDAANKN 525
+ ++ + EI+D++++ D I K K+A EEQ+++L E ++ ++
Sbjct: 1687 SEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQED 1746
Query: 526 MIKVKSNHKLKLKQMQKTI----DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
M ++ HK + Q + + D +++ ++NKE L E+L L +V LE+
Sbjct: 1747 MNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---- 1802
Query: 582 QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVE 641
+VD + + S K+ E+E E + LES L + + L ++ D+
Sbjct: 1803 ---MVD----KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQ-R 1854
Query: 642 DKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ + Q+ ++ +++ +E++ L+ + E + L++D E L + L+
Sbjct: 1855 IAAENREKEQNKRLQRQLRDT--KEEMGELARKEAEASRKKHELEMDLESLEAANQSLQA 1912
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ 758
D + + LQ I++ M+ +D+ E + + +++ K + ++K++ +D++++
Sbjct: 1913 DLKLAFKRIGDLQAAIEDEME-SDENEDL-INSLQDMVTKY-QKRKNKLEGDSDVDSELE 1969
Query: 759 ERDLYIENIESELSKYK 775
+R ++ ++S LSK K
Sbjct: 1970 DR---VDGVKSWLSKNK 1983
>AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related
protein protein.
Length = 1820
Score = 87.8 bits (208), Expect = 3e-16
Identities = 209/1042 (20%), Positives = 432/1042 (41%), Gaps = 107/1042 (10%)
Query: 562 EELHHLSQKVAELE--EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
E+L V ELE EE N++ L+D D + +E + K I E + K + L+
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEEN--KAFISHEE----KRKLLDLI 580
Query: 620 ESQKFDLVQEL-HILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
E K L+ E L ++ E+ + +Q + + ++ K L+E+ + L + +
Sbjct: 581 EDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQRE-ADFKETLLQER-EILEENAERR 638
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK 738
+ ++L + KD+ K + + NY+ D+ D L+ A+ + A+
Sbjct: 639 LAIFKDLVGKCDTREEAAKDICATKVET-EETHNYVGFE-DIIDSLQDNVADIKKQ--AE 694
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
I H + + A ++ L I++EL+K K + + +E L+++
Sbjct: 695 IAHLYIASLPDPQEATACLE---LKFNQIKAELAKTKGELIKTKEE----------LKKR 741
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
++ S +QE + + + I +++ + L ++D +K+ E +N + +N
Sbjct: 742 ENESDSLIQELKTSIKKI-ITQNQRIKELINIID-----QKEDTINEFQNLKSLMENTFK 795
Query: 859 LEENQNLQISLSDMQQHYNALVE--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQT 916
+ + + + + N VE K +++ + + +L+ E K+ + +
Sbjct: 796 CNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSS 855
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNM 976
I + +K+ E++ + I D +VL E E ++ +E +L+ K LN
Sbjct: 856 AITEDQKKSEEVRPNI-----AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK 910
Query: 977 NVEELNKMNLELIDKH---VQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
+ + L L +K + K+ Q + I E++ + ++++E+I+ L+ +I
Sbjct: 911 QIVHFQQ-ELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIE 969
Query: 1034 NAQVSYMSMVSDYE---SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDD 1090
A S + VS + +K+ + T L+++ + L D +EE + + D
Sbjct: 970 TATRSITNNVSQIKLMHTKIDELRT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 1028
Query: 1091 QIKELKETKLTFEMNI--PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ--- 1145
+ +K E I P E SS IE + ++ + L+ Q
Sbjct: 1029 LGNDYLVSKQVKEYRIQEPNRENSFHSS-IEAIWEECKEIVKASSKKSHQIEELEQQIEK 1087
Query: 1146 ---EEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL--- 1199
E + + E + L+E+ K +L + +IQ L EL +V QI +
Sbjct: 1088 LQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQ--QLKEELQEKNVTLDVQIQHVVEG 1145
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
K L +L + + EL + + + +R A+L +Q + ++E+ K E L+
Sbjct: 1146 KRALSELTQGVTCYKAKIKELETILETQKVERSHS-AKL-EQDILEKESIILKLERNLK- 1202
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
F+ E L DSV+++ ++ E++T L N LQD +HL L+E+ + Q
Sbjct: 1203 ---EFQ---EHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ 1255
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
E EK+ DL+ + + Y ++E+ + + ++ Q++K
Sbjct: 1256 --------ETEKL--KEELSASSARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQK 1304
Query: 1380 SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQ 1439
++N+ E K + + +L++K I Q Q N+ + V +
Sbjct: 1305 EVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE-------QLNN--QKVEE 1355
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESV 1499
+ +YE+ +DL KE + +R+ + E +T ++ ++ KL EE+ TE
Sbjct: 1356 AIQQYERACKDLNV-KEKIIEDMRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATELE 1410
Query: 1500 SLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK-IQKHV 1558
++ +L + K +E T + ++ L DE+ + A K +++ +
Sbjct: 1411 KWKEKCNDLETKNNQRSNKEHENNTDVLG---KLTNLQDELQESEQKYNADRKKWLEEKM 1467
Query: 1559 SFASDTKQGRDEQLDNTMNKEL 1580
+ K+ +N NKE+
Sbjct: 1468 MLITQAKEA-----ENIRNKEM 1484
Score = 84.2 bits (199), Expect = 3e-15
Identities = 220/1105 (19%), Positives = 461/1105 (41%), Gaps = 100/1105 (9%)
Query: 486 KQELNDEIKDVNVKDLIEKLKSAEE----QITQLNDEIDAA---NKNMIKVKSNHKLK-- 536
+ L D ++D +DL+E+L++AEE + L++++D NK I + KL
Sbjct: 523 ENSLEDLMED---EDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDL 579
Query: 537 LKQMQKTIDNFSKVSDSNKEIVR--LTEEL-HHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
++ ++K + N K + + +R +T+E + +Q+ A+ +E + L + R+
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 594 -IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED--KLADISQL 650
I D+ K E A+ + A + + + V I+ D V D K A+I+ L
Sbjct: 640 AIFKDLVGKCDTREEAAKD-ICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAEIAHL 698
Query: 651 --------QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
Q C E+K ++ + L+ +K EL E LK + + I++L+
Sbjct: 699 YIASLPDPQEATACLELKFNQIKAE---LAKTKGELIKTKEELKKRENESDSLIQELKTS 755
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDL 762
+ I+ + Q I+E +++ D+ E + + L + + E K + + I L
Sbjct: 756 IKKIITQNQR-IKELINIIDQKED-TINEFQNLKSLM--ENTFKCNDKADTSSLIINNKL 811
Query: 763 YIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTIQE 820
KS+IC + + E ++ K + S + E QK E
Sbjct: 812 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI 871
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
E+ + + VL +++ + LL IE+E K + EE L + QQ + L
Sbjct: 872 AEIED-IRVLQENNEGLRAFLLTIENELKNEK-------EEKAELNKQIVHFQQELS-LS 922
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IESA 939
EK N T E + + + E ++++ ++ Q + K EIE T+ I +
Sbjct: 923 EKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSN----EIETATRSITNN 978
Query: 940 IRDKKVLNEKYE--KNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKM-NLELIDKH 992
+ K+++ K + + ++ V+Q+ L++ N E N+ +L+ + N L+ K
Sbjct: 979 VSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ 1038
Query: 993 VQKQQTQSPDYTEQYINEINKL----NALLK---QKDEEIIALNQKINNAQVSYMSMVSD 1045
V++ + Q P+ + + I + ++K +K +I L Q+I Q D
Sbjct: 1039 VKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY-KD 1097
Query: 1046 YESKLAQFTTK-LENMEEEMQRVSKQLLDSKQH-NEELQILVR---EQDDQIKELKETKL 1100
++L + K +++ +E + + +QL + Q N L + ++ E + EL +
Sbjct: 1098 ENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVT 1157
Query: 1101 TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER----SV 1156
++ I + E ++ + +E D ++E +E +Q+
Sbjct: 1158 CYKAKIKELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKD 1217
Query: 1157 LQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
L + KL E+ + + ++ L + N+++ +LK +L + NL
Sbjct: 1218 LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK-- 1275
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQ-HLAQREADFQKTEHEL-RVQLSAFESKYEQL--- 1271
A+L+ D + ++ + KQ Q+E + E +L R++++ E K Q
Sbjct: 1276 -ADLQRKEEDYADLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQE 1333
Query: 1272 LDSVQSSTQ---EETNKIVTMEQVTSLQNKLQD---KEEHLRNLQEKYADVINQIEILRS 1325
LD Q + Q E+ N E + + +D KE+ + +++ + Q ++ +
Sbjct: 1334 LDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ-EQTQVEQD 1392
Query: 1326 EIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXX 1385
++ + K+ DL T+N + ++ ++ + L+
Sbjct: 1393 QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQE 1450
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
R E K++ +T E +++ E+ + + Q+N E E + QL
Sbjct: 1451 SEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN-EMEILTAQLT 1509
Query: 1443 EYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLN 1502
E + ++ E++ +A L +++ A +QK++EIE++K I KI E+ ++
Sbjct: 1510 EKDSDLQKWREERDQLVAALEIQL--KALISSNVQKDNEIEQLKRIISETSKI-ETQIMD 1566
Query: 1503 KQVAELNKALEEEVAKTNEMQTALE 1527
+ ++ A + + +T + T+ E
Sbjct: 1567 IKPKRISSA-DPDKLQTEPLSTSFE 1590
Score = 83.0 bits (196), Expect = 8e-15
Identities = 161/753 (21%), Positives = 334/753 (44%), Gaps = 87/753 (11%)
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKL-- 535
++K +Q++ + I +++V+ K + EE+I +L++EI+ A +++ S KL
Sbjct: 929 LSKEVQQIQSNYDIAIAELHVQK--SKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 986
Query: 536 -KLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K+ ++ +T+D+ S++ SN +++ L +L + S+ E+ N QL L+ D ++
Sbjct: 987 TKIDEL-RTLDSVSQI--SNIDLLNL-RDLSNGSE-----EDNLPNTQLDLLGND--YLV 1035
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
V + I+ N + +I + ++E ++ + S +S Q
Sbjct: 1036 SKQVKEYRIQEPNRENSFHSSIEAI-----------------WEECKE-IVKASSKKSHQ 1077
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYI 714
+ LE+QI+ L A K EN +L KE+ + DL +KE ++ +L+ +
Sbjct: 1078 I------EELEQQIEKLQAEVK--GYKDENNRL-KEKEHKNQDDLLKEKETLIQQLKEEL 1128
Query: 715 QE-NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
QE N+ L +++ + K +SEL + + AKI+E + +E + E
Sbjct: 1129 QEKNVTLDVQIQHVVEGKRALSELTQGVTCYK-----------AKIKELETILETQKVE- 1176
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+S +LE+ I E LER + +LQ+ K + ++E +L + L
Sbjct: 1177 ---RSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT 1233
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK-ANRTDLAE 890
++ + + K LL+++ E +E ++ L+E L S + Q L K + DL E
Sbjct: 1234 NNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNLKADLQRKEEDYADLKE 1290
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ T + Q++ ++ + + E + L + K E+E + + + +++ R + L E+
Sbjct: 1291 -KLTDAKKQIKQVQKEVSVMRDEDKLLRI-KINELEKKKNQCSQELDMKQRTIQQLKEQL 1348
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
++E +Q+Y+ ++LN+ + + M + L ++ ++ Q + E + E
Sbjct: 1349 NNQ-----KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ--EQTQVEQDQVLEAKLEE 1401
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
+ +L L++ E+ L K N +D KL +L+ E++ K+
Sbjct: 1402 VERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKK 1461
Query: 1071 LLDSK-----QHNEELQILVREQDDQIKELKE-TKLTFEMNIPKTEGMIISSTIEPMSDD 1124
L+ K Q E I +E ++ + K EM I + S ++ ++
Sbjct: 1462 WLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREE 1521
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQL---ETL 1181
+ + VQ++ E Q + ++ E S K+ T++ + K I + L
Sbjct: 1522 RDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS-KIETQIMDIKPKRISSADPDKL 1580
Query: 1182 NTE-LTGHDVVNQEQINQLKSKLE--QLNTEND 1211
TE L+ +++ +I L+ + +TEND
Sbjct: 1581 QTEPLSTSFEISRNKIEDGSVVLDSCEASTEND 1613
Score = 59.3 bits (137), Expect = 1e-07
Identities = 133/726 (18%), Positives = 305/726 (42%), Gaps = 50/726 (6%)
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
E NQD K + I +L+ +Q N L V ++V+ K K I
Sbjct: 1106 EHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK-AKIK 1164
Query: 451 QLQ--LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ---ELNDEIKDVNVKDLIEKL 505
+L+ LE Q+ S E + I K++ LK+ L D +K N KDL K
Sbjct: 1165 ELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK--NTKDLNVKE 1222
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
+E+ITQL + + K+++++K + +Q + + ++S S+ L +L
Sbjct: 1223 LKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNLKADLQ 1279
Query: 566 HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKAISLLESQKF 624
+ A+L+E+ + + + + D K + I++ L + + + SQ+
Sbjct: 1280 RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC-----SQEL 1334
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSE--IKSVHLEEQIDALSASKKELALVI 682
D+ Q +QQ +++ ++ + + Q ++ C + +K +E+ L ++
Sbjct: 1335 DMKQRT--IQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQD 1392
Query: 683 ENLKLDKEQLYGTIKDLE------NDKEDIMNKLQNYIQEN-MDLTDKLEKMSAEKISEL 735
+ L+ E++ +LE ND E N+ N EN D+ KL + E + E
Sbjct: 1393 QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE-LQES 1451
Query: 736 LAKINHEEQSKIQTQFGIDAKIQE----RDLYIENIESELSKYKSRICRLEESIAVMEDR 791
K N + + ++ + + + +E R+ ++ + ++ + +E A + ++
Sbjct: 1452 EQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEK 1511
Query: 792 RYSLER---KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
L++ + DQL + L+ + KA +Q+D + +L ++ +E Q+++I+ +
Sbjct: 1512 DSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKR 1571
Query: 849 KELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY-----QTQLRD 902
+++ E + + +IS + ++ ++V + +ST++ + Q
Sbjct: 1572 ISSADPDKLQTEPLSTSFEISRNKIED--GSVVLDSCEASTENDQSTRFPKPELEIQFTP 1629
Query: 903 LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
L+ N + H T V K + + + N E ++ + N N+++ +
Sbjct: 1630 LQPNKMAVKHPGCTTPVTVKIP-KARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDR 1688
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
K + + ++ + + V + +++ + + ++L+ K
Sbjct: 1689 NSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKA 1748
Query: 1023 EEIIAL--NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++II + K++N + S ++ +K +T+++ + + +V L+D K +
Sbjct: 1749 KKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVI--LMDQKMKESD 1806
Query: 1081 LQILVR 1086
QI+ R
Sbjct: 1807 HQIIKR 1812
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 1207 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 1265
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 1266 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 1321
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 1322 ELEKKKNQCSQELD 1335
>AB011127-1|BAA25481.2| 802|Homo sapiens KIAA0555 protein protein.
Length = 802
Score = 87.8 bits (208), Expect = 3e-16
Identities = 148/784 (18%), Positives = 338/784 (43%), Gaps = 57/784 (7%)
Query: 552 DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR--MIESDVYKKMIEMENLA 609
D ++ + ELH KV++LE EK + + + + ++ +++ K+ E E +
Sbjct: 28 DLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHE-EKMK 86
Query: 610 ETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
E + +L++ + ++ + + + + ++ L + SD+V + + EE
Sbjct: 87 ELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARK 146
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA 729
+ +L I +LK K+Q+ + ++ + L++ Q + + K++ S
Sbjct: 147 LFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESE 206
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
I L+ +I ++K + F ++ +++ + Y++ ++ + ++ ++E+ M
Sbjct: 207 RDIRRLMDEI----KAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMS 262
Query: 790 DRRYSLERKADQLGSY-----LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ + +A + L+ QK +E +L +R +L D + K++ E
Sbjct: 263 SPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRET 322
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN--RTDLAESESTKYQTQLRD 902
E + K L ++N+ L + N L +SL M++ A+ ++ + R + K L D
Sbjct: 323 EKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLND 382
Query: 903 LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY-VTQLE 961
L+ + E L V +++ I D E E IR +K + + K I+ V
Sbjct: 383 LDQANEEQETEFLKLQVIEQQNIID---ELTRDREKLIRRRK--HRRSSKPIKRPVLDPF 437
Query: 962 AQLQEYKNNIENLNM---NVEELNKMNLELIDKHV--QKQQTQSPDYTEQYINEINKLNA 1016
E + E +M + + +D+ + ++ + + T++Y + + A
Sbjct: 438 IGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEY-QALQRAYA 496
Query: 1017 LLKQK-----DEEIIALNQKINNAQV-SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
LL+++ D E A Q+ A+V Y + + D E+ LAQ ++E E E R+ ++
Sbjct: 497 LLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQ-KGQIEKQEAENHRLQQE 555
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD- 1129
L D++ NE L+ ++ +++E + F + I + + I M + +V+
Sbjct: 556 LQDARDQNELLEF----RNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNI 611
Query: 1130 ---XXXXXXXXXXXXLKVQEEEEFIQERSVL---QEQSAKLNTELQECYTKIIQLETLNT 1183
L+ +E+ IQ +VL ++ ++ + K+++LE+
Sbjct: 612 PDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDME 671
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRG-FEIAELWKQH 1242
+ +E+++ K L+Q + EL +++ +A+ Q + EL +
Sbjct: 672 QFCKIKGYLEEELDYRKQALDQ-------AYMRIQELEATLYNALQQETVIKFGELLSE- 723
Query: 1243 LAQREADFQKTEHELRVQLSAFESKYE-QLLDSVQSSTQEETNKIVTMEQVTSLQNK-LQ 1300
+++ + + +LR Q+ +Y+ Q+L Q+ +I +E T +Q + ++
Sbjct: 724 --KQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIK 781
Query: 1301 DKEE 1304
D EE
Sbjct: 782 DLEE 785
Score = 58.4 bits (135), Expect = 2e-07
Identities = 127/654 (19%), Positives = 277/654 (42%), Gaps = 57/654 (8%)
Query: 453 QLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL-KQELNDEIKDVNVKD-LIEKLKSAEE 510
+LE ++H + + + E + E+ V+E L KQ + + V V+D I++LKSA
Sbjct: 63 ELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSA-- 120
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQ- 569
+ L D + + +++ + + + + +++D ++ E L ++ Q
Sbjct: 121 -LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA 179
Query: 570 ---KVAELEEEKGNLQ--LHLVDYDSGRMIE---SDVYKK---MIEMENLAETRLKAISL 618
K +L E + Q + + ++S R I ++ K + +E ET+ +
Sbjct: 180 DKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQK 239
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSD--QVCSEIKSVHLEEQIDALSASKK 676
L+ QK L ++L ++++ + +I D + CS +++I L+A+ +
Sbjct: 240 LQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIR 299
Query: 677 ELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+L L ++ +L +++ E + ++ + + + N +L L++M EK+ + +
Sbjct: 300 KLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRME-EKL-KAV 357
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
K N E + KI + + DL N E E K ++ + I + R L
Sbjct: 358 TKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLI 417
Query: 797 RKADQLGSYLQEKQKAYSEYT-IQEDELVNRLAVLM----DHDRVVEKQLLEIEHENKEL 851
R+ S K+ + ED + + + + D L+ +E
Sbjct: 418 RRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEES 477
Query: 852 QKKNQILLEENQNLQISLSDMQQHYNALVE---KANRTDLAESESTKYQTQLRDLESNLK 908
+ + + L +E Q LQ + + +Q+ +++ +A + ++E +Y+ ++ DLE+ L
Sbjct: 478 ELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLA 537
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE-KNIEYVTQ------LE 961
+ K +IE E E N +++ ++D + NE E +N+E +
Sbjct: 538 Q------------KGQIEKQEAE-NHRLQQELQDARDQNELLEFRNLELEERERRSPPFN 584
Query: 962 AQLQEYKNNIENLNMNV--EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLK 1019
Q+ + + + L + E + +N+ + K + E+ + I + + +L
Sbjct: 585 LQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQV-AIIQASTVLS 643
Query: 1020 QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
++ I Q+I A+ + + + ES + QF +EEE+ KQ LD
Sbjct: 644 LAEKWI----QQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELD-YRKQALD 692
Score = 46.0 bits (104), Expect = 0.001
Identities = 143/793 (18%), Positives = 323/793 (40%), Gaps = 61/793 (7%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
+ +I+ EL + KS++ +LE R LE++ + + E + E ++E +
Sbjct: 33 LTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTV--LVTELKAKLHEEKMKELQA 90
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
V R ++ H++ + + ++ + E+Q+ L L+ SD + + +
Sbjct: 91 V-RENLIKQHEQEMSRT---VKVRDGEIQRLKSALCA----LRDGSSDKVRTALTIEARE 142
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES----- 938
L ++E K ++ DL++ K++ +I K + DL E + E+
Sbjct: 143 EARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIK 202
Query: 939 --AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK---HV 993
+ RD + L ++ + + LE +L+ ++ L + E L++ L L+ + ++
Sbjct: 203 WESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ-LFLVKEAECNM 261
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQF 1053
+ + P + + L++ + I LN I + +++ D ++L +
Sbjct: 262 SSPKREIPGRAGDGSEHCSSPD--LRRNQKRIAELNATIRKLE-DRNTLLGDERNELLKR 318
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
+ E + + +K L + N+EL + ++ ++++K + TK EM E +
Sbjct: 319 VRETEKQCKPLLERNKCLA---KRNDELMVSLQRMEEKLKAV--TKENSEMR----EKIT 369
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
++ + N++D L+V E++ I E + +++ + +
Sbjct: 370 SHPPLKKLKS-LNDLDQANEEQETEFLKLQVIEQQNIIDE--LTRDREKLIRRRKHRRSS 426
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
K I+ L+ + G+D ++ ++ S + T+ +L S+ A ++
Sbjct: 427 KPIKRPVLDPFI-GYD---EDSMDSETSSMASFRTDRTPATPD-DDLDESL--AAEESEL 479
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
+L K++ A + A E + + E+K ++ L Q+ KI +E
Sbjct: 480 RFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQL---QAEVLRYKAKIEDLEATL 536
Query: 1294 SLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLR 1353
+ + +++ +E LQ++ D +Q E+L E + ++ D
Sbjct: 537 AQKGQIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERERRSPPFNLQIHPFSDGV 594
Query: 1354 TENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
+ Q Y + +NI + QL N+ + +++ + L L +
Sbjct: 595 SALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLR--------NEEQVAIIQASTVLSLAE 646
Query: 1414 SEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI-EDLTYEKES-ELAILRLKMHENAN 1471
I Q+ L Q+ E E+ +Q + + + E+L Y K++ + A +R++ E A
Sbjct: 647 KWI-QQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELE-AT 704
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEI 1531
Y +Q+E+ I+ +L+ E + + + L K+ E + E L+
Sbjct: 705 LYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQ 764
Query: 1532 EIVTLNDEITNLQ 1544
I L D+ T++Q
Sbjct: 765 RIRDLEDK-TDIQ 776
Score = 35.1 bits (77), Expect = 2.1
Identities = 41/184 (22%), Positives = 83/184 (45%), Gaps = 22/184 (11%)
Query: 489 LNDEIKDVNVKDLIEKLK--------SAEEQ--ITQLNDEIDAANKNMIKVKSNHKL--- 535
+ + +KDVN+ DLI++L EEQ I Q + + A K + +++
Sbjct: 602 MKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQ 661
Query: 536 KLKQMQKTIDNFSKVSD-SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K+ +++ ++ F K+ +E+ + L ++ ELE N G ++
Sbjct: 662 KMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELL 721
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFD---LVQELHILQQKYDEVEDKLADISQLQ 651
K+ E+ E +L+ L +S+++D L + + +LQQ + + D L D + +Q
Sbjct: 722 SE---KQQEELRTAVE-KLRRQMLRKSREYDCQILQERMELLQQAHQRIRD-LEDKTDIQ 776
Query: 652 SDQV 655
Q+
Sbjct: 777 KRQI 780
>AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-1
protein.
Length = 795
Score = 87.4 bits (207), Expect = 4e-16
Identities = 130/588 (22%), Positives = 275/588 (46%), Gaps = 74/588 (12%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVN------------VKDLIEKLKSAEEQITQLNDEID 520
ED +I ++++ K+E+ND+ K V+ +KDL L+ + +++ QL ++
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
Query: 521 AANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
++N+ + ++ H L K+++ + + + K L E+L ++ + +L EEK
Sbjct: 305 LQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQK---ALEEDLQIATKTICQLTEEK- 359
Query: 580 NLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + + R S V + + +E L T + + E Q L E LQ+
Sbjct: 360 --ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME---LQK 414
Query: 636 KYDEVED--KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K E+E+ KL + +++ + E+K V E+ + L K+ + E LK +++L
Sbjct: 415 KSSELEEMTKLTNNKEVELE----ELKKVLGEK--ETLLYENKQFEKIAEELKGTEQELI 468
Query: 694 GTIKDLENDKEDIMNKL-------QNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
G ++ E + D+ +L Q Y +E DL +LE K +EL + N ++
Sbjct: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLEN 527
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
K TQ + + L ++N + +++ K + R+ + I +++ L + + +
Sbjct: 528 KELTQ-----ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
L++K+ + +E N L +++ K + E++ ENK L+KK ++
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENK---NKYIEELQQENKALKKKGTA-----ESK 634
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q+++ +++ + L ++ + E T YQ ++ D K+I+ E+ V+K K I
Sbjct: 635 QLNVYEIKVNKLELELESAKQKFGEITDT-YQKEIED-----KKISEENLLEEVEKAKVI 688
Query: 926 ED----LEIEFNTQIESAIRDKKVLNEKYEKNIE-YVTQLEAQLQEYKNNIE---NLNMN 977
D L+ E + + + I + L EK++ + + + +++L YK+ + +L +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRAS 748
Query: 978 VE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+E EL+ + EL+ V+KQ + E+ E + A LK+K ++
Sbjct: 749 LEIELSNLKAELLS--VKKQLEIEREEKEKLKREAKENTATLKEKKKK 794
Score = 77.0 bits (181), Expect = 5e-13
Identities = 143/675 (21%), Positives = 278/675 (41%), Gaps = 65/675 (9%)
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKL-- 537
Q++ K + N +I + K I++L+ E+++ +E NK++IK + H L
Sbjct: 129 QKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK-VAELEE-----EKGNLQLHLV---DY 588
+ ++ + K +E ++ +L++ +K + EE E L++H DY
Sbjct: 188 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDY 247
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ + +E + K++ + E L I+ E++ DL L + K +++E+K +
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK----T 303
Query: 649 QLQSDQVCSEI-KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+LQS+ + I K HL ++++ + S + + L+ D + TI L +KE M
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
Query: 708 NKLQNYIQENMDLTDKLEKM--SAEKI--SELLAKINHEEQSKIQTQF--GIDAKIQERD 761
+ + + + E S E++ +E +E+Q KI T ++++E
Sbjct: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYS-----LERKADQLGSYLQEKQKAYSEY 816
N E EL + K + E+ + E++++ L+ +L LQ ++K +
Sbjct: 424 KLTNNKEVELEELKKVLG--EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
IQ + + ++ +L + +N EL L EN+ L SDM
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFN 933
E N E K L++ E+ L+ + + QK+ E++ D E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 934 TQIESAIRDK-KVLNEKYEKNIEYV---TQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + +K K + E ++N T QL Y+ + L + +E + E+
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNA-------LLKQKDE-------EIIALNQKINNA 1035
D + QK+ E + E+ K L K+ D+ E++AL +K +
Sbjct: 662 DTY-QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 1036 QVS-----------YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
Y S + S A +L N++ E+ V KQL ++ E+L+
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 1085 VREQDDQIKELKETK 1099
+E +KE K+ K
Sbjct: 781 AKENTATLKEKKKKK 795
Score = 73.3 bits (172), Expect = 6e-12
Identities = 142/672 (21%), Positives = 276/672 (41%), Gaps = 52/672 (7%)
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
EN K+ + Q I++L+ E + KL+ IQEN DL E + + LL +
Sbjct: 136 ENRKIIEAQRKA-IQELQFGNEKVSLKLEEGIQENKDLIK--ENNATRHLCNLLKETCAR 192
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
K + ++ + + + R +Y++ + + + K I EE E+ R + K +
Sbjct: 193 SAEKTK-KYEYERE-ETRQVYMD-LNNNIEK---MITAFEELRVQAENSRLEMHFKLKED 246
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+Q ++ Y + +++ V+ L + + K L + E+++ K NQ LEE
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD--KVNQ--LEEK 302
Query: 863 QNLQ---ISLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTL 917
LQ + S +QH+ + + L S ST+ + L+ + ++T E +T
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
Query: 918 IVQKKK---EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + K + EF T + S + ++ EKN + + L +LQ+ + +E +
Sbjct: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ ++ LE + K + +++T Y + + K+ LK ++E+I L Q
Sbjct: 423 T-KLTNNKEVELEELKKVLGEKETLL--YENK---QFEKIAEELKGTEQELIGLLQ---- 472
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ V D E +L TT + +E++ + +L + K N EL + + KE
Sbjct: 473 ---AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE 529
Query: 1095 L-KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEE 1149
L +ET +T E+ + + E M N+ ++ Q+ +E
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ +E L +++ I +L+ N L +Q+N + K+ +L E
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELE 649
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFE----IAELWKQHLAQREADFQKTEHELRVQ----- 1260
++ E+ + ++ + + E+ K + EA + E + R Q
Sbjct: 650 LESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE 709
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+ A K++ D + E + EQ +SL+ L E L NL+ + V Q
Sbjct: 710 MVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNLKAELLSVKKQ 766
Query: 1320 IEILRSEIEDEK 1331
+EI R E E K
Sbjct: 767 LEIEREEKEKLK 778
Score = 67.3 bits (157), Expect = 4e-10
Identities = 122/615 (19%), Positives = 256/615 (41%), Gaps = 59/615 (9%)
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E++LQE + IE ++EL N E + +++ ++ D ++ N L LL
Sbjct: 129 QKESKLQENRKIIEAQRKAIQELQFGN-EKVSLKLEEGIQENKDLIKEN-NATRHLCNLL 186
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQH 1077
K+ +K + + D + + + T E + + + ++ K+
Sbjct: 187 KETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKED 246
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E++Q L +E +I + ++ + I + E + T + +++ +
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF--LLEESRD---------- 294
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
KV + ++E++ LQ ++ K + E Q TK +LE + L V Q+ +
Sbjct: 295 -----KVNQ----LEEKTKLQSENLKQSIEKQHHLTK--ELEDIKVSLQ-RSVSTQKALE 342
Query: 1198 ---QLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ +K + QL E + + + R++ S V + + L ++ L + +K
Sbjct: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL-EELLRTEQQRLEKN 401
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTMEQVTSLQNKLQDK-EEHLR 1307
E +L++ + K +L + + + EE K++ ++ +NK +K E L+
Sbjct: 402 EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELK 461
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE--NQSYKQMQEQ 1365
++ ++I ++ E+ D ++ DL+TE N+ K +
Sbjct: 462 GTEQ---ELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK-DLKTELENEKLKNTELT 517
Query: 1366 SILN-INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
S N ++ EN +L + + +N+ + + + LK E Q+T
Sbjct: 518 SHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-----EERMLKQIENLQETE--- 569
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY-ETMQKESEIE 1483
TQ +E E VR++L + ++ + E LR K EN N Y E +Q+E++
Sbjct: 570 ---TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR-KQVENKNKYIEELQQENKAL 625
Query: 1484 RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+ K E + +NK EL A ++ T+ Q +E+++I L +E+
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA 685
Query: 1544 QNMVRASSSKIQKHV 1558
+ ++ + K+QK +
Sbjct: 686 K-VIADEAVKLQKEI 699
Score = 51.2 bits (117), Expect = 3e-05
Identities = 110/585 (18%), Positives = 243/585 (41%), Gaps = 60/585 (10%)
Query: 151 IKEKDNALSVLQVKMKIMETTILDLQEKINE-KDQI--IEAKNKATTXXXXXXXXXXXXX 207
I +K+ +S+L +++ E + DL + E +D++ +E K K +
Sbjct: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL 320
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
ED K + + A+E + + + + + E K+ + +EE+NK A F +
Sbjct: 321 TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ---MEESNKARAAHSFVV 377
Query: 268 SLEHSKLA--QEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ + + +EL EQ + Q EE T++ +E+ +
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + E L + N Q + +EL+ GTE + + + + + +
Sbjct: 438 KVLGEKETLLYENKQFEKIAEELK------GTEQELIGLLQAREKEVHDLEIQLTAITTS 491
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ +S+ + + ++K+ E+ + NK+L + ++ +
Sbjct: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
++ + + Q+E+ Q T T+ NE+ V+E+LKQ+ DE+K
Sbjct: 552 KKQEERMLK-QIENLQE----------TETQLRNELEYVREELKQK-RDEVKC------- 592
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
KL +EE L +++ NK + +++ +K LK +K +++ ++ +L
Sbjct: 593 -KLDKSEENCNNLRKQVENKNKYIEELQQENK-ALK--KKGTAESKQLNVYEIKVNKLEL 648
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
EL QK E+ + + + + ++ E ++ +++ + + +A+ +K ++ +
Sbjct: 649 ELESAKQKFGEITD------TYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKR 702
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+ E+ L +K+ DK+ + + D KS E+ S+ + L + +
Sbjct: 703 CQHKIAEMVALMEKHKHQYDKIIE----ERDSELGLYKSKEQEQ-----SSLRASLEIEL 753
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN-MDLTDKLEK 726
NL K +L K LE ++E+ KL+ +EN L +K +K
Sbjct: 754 SNL---KAELLSVKKQLEIEREE-KEKLKREAKENTATLKEKKKK 794
>AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein
protein.
Length = 1331
Score = 87.0 bits (206), Expect = 5e-16
Identities = 109/604 (18%), Positives = 277/604 (45%), Gaps = 35/604 (5%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
E++ + EE++ ++ ++ AA + ++++ L+ + M + + + + E+ E
Sbjct: 709 EEMMAKEEELVKVREKQLAAENRLTEMET---LQSQLMAEKLQ-LQEQLQAETELCAEAE 764
Query: 563 ELH-HLSQKVAELEEEKGNLQLHLVDYDSG-RMIESDVYKKMIEMENLAETRLKAISLLE 620
EL L+ K ELEE +L+ + + + + ++++ K ++ L E + S +
Sbjct: 765 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 824
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
+ + V L++ +E++D L D+ Q C+ K +++ D L A +K ++
Sbjct: 825 KLQLEKVTTEAKLKKLEEELDDLLVDLDH-QRQSACNLEKK---QKKFDQLLAEEKTISA 880
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK-- 738
++++ ++ E + L+ +++ +L ++L K ++ +L++
Sbjct: 881 KYAG---ERDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMSSKD 936
Query: 739 -INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLE 796
+ +++ ++ +++E +E +E EL + RLE ++ M+ + L+
Sbjct: 937 DVGKSVHELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQ 996
Query: 797 RKADQLGSYLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ +Q ++ + E + EDE R + ++ E L ++E K
Sbjct: 997 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSANKNR 1055
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
+++ + LQ + D + + +A+R ++ +++ + + +L+ +E+ + ++ E
Sbjct: 1056 DEAIKQLRKLQAQMKDCMRELDDT--RASREEIL-AQAKENEKKLKSMEAEMIQL-QEEL 1111
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
+ K++ + E +I ++ + E+ + + QLE +L+E + N E +N
Sbjct: 1112 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1171
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
+ L K NL+ ID+ + + ++ NE N L +Q E + L +
Sbjct: 1172 ---DRLKKANLQ-IDQ-INTDLNLERSHAQK--NE-NARQQLERQNKELKVKLQEMEGTV 1223
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ Y + ++ E+K+AQ +L+N +E Q KQ+ ++ ++L+ ++ + DD+ +
Sbjct: 1224 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQV---RRTEKKLKDVLLQVDDERRNA 1280
Query: 1096 KETK 1099
++ K
Sbjct: 1281 EQYK 1284
Score = 78.6 bits (185), Expect = 2e-13
Identities = 110/559 (19%), Positives = 237/559 (42%), Gaps = 60/559 (10%)
Query: 613 LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD----------------QVC 656
L +S E + +EL +++K E++L ++ LQS ++C
Sbjct: 701 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 760
Query: 657 SE---------IKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+E K LEE L A +E ++L+ +K+++ I++LE E+
Sbjct: 761 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 820
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENI 767
+ Q E + KL+K+ E++ +LL ++H+ QS ++ K ++ D +
Sbjct: 821 SARQKLQLEKVTTEAKLKKLE-EELDDLLVDLDHQRQSAC----NLEKKQKKFDQLLAEE 875
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-- 825
++ +KY R E E + SL R ++ E ++ ++ + ++L++
Sbjct: 876 KTISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 935
Query: 826 -----RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
+ L R +E+Q+ E++ + +EL+ + Q + L+++L M+ +
Sbjct: 936 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFER-- 993
Query: 881 EKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEF---NT 934
+ R + +E + + Q+R++E+ L+ + + +KK +++DLE N
Sbjct: 994 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1053
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY----KNNIENLNMNVEELNKMNLELID 990
+ AI+ + L + + + + A +E K N + L E+ ++ EL
Sbjct: 1054 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1113
Query: 991 KHVQKQQTQS--PDYTEQYINEINKLNALLKQK---DEEIIALNQKINNAQVSYMSMVSD 1045
K+Q Q + ++ N K L++K + I L +++ Q +++D
Sbjct: 1114 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ-GNTELIND 1172
Query: 1046 YESK----LAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT 1101
K + Q T L Q+ ++ N+EL++ ++E + +K + +T
Sbjct: 1173 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1232
Query: 1102 -FEMNIPKTEGMIISSTIE 1119
E I + E + + T E
Sbjct: 1233 ALEAKIAQLEEQLDNETKE 1251
Score = 60.1 bits (139), Expect = 6e-08
Identities = 114/613 (18%), Positives = 247/613 (40%), Gaps = 61/613 (9%)
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
N + ++ L Q E + L +++ + + ++ E A+ T K + +EE +
Sbjct: 730 NRLTEMETLQSQLMAEKLQLQEQLQ----AETELCAEAEELRARLTAKKQELEEICHDLE 785
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKT--EGMIISSTIEPMSDDAN 1126
++ + ++ + LQ ++ I+EL+E E K E + + ++ + ++ +
Sbjct: 786 ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEELD 845
Query: 1127 N--VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA----KLNTELQECYTKIIQLET 1180
+ VD K ++ ++ + E + + A + E +E TK + L
Sbjct: 846 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAGERDRAEAEAREKETKALSLAR 905
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
E + Q ++++E L + D++ +V EL S A++Q+ E K
Sbjct: 906 ALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS-KRALEQQ----VEEMK 960
Query: 1241 QHLAQREADFQKTEH---ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM--EQVTSL 1295
L + E + Q TE L V L A ++++E+ L ++E+ ++V E L
Sbjct: 961 TQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1020
Query: 1296 QNK-----------------LQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+++ L+D E H+ + + + I Q+ L+++++D
Sbjct: 1021 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1080
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
EN+ + E ++ + EE A +++ + ++
Sbjct: 1081 ASREEILAQA-----KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1135
Query: 1399 EAK---VLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
K LE +LE + +++ ++ E Q N E N R L + +I+ +
Sbjct: 1136 SGKGALALEEKRRLEARIAQLEEELEE-----EQGNTELINDR--LKKANLQIDQI---- 1184
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIE-ELNVKITESVSLNKQVAELNKALEE 1514
++L + R +N N + ++++++ +VKL E E VK S+ A++ + E+
Sbjct: 1185 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1244
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
+T E Q A + L D + + + R ++ + + AS + QL+
Sbjct: 1245 LDNETKERQAACKQVRRTEKKLKDVLLQVDD-ERRNAEQYKDQADKASTRLKQLKRQLEE 1303
Query: 1575 TMNKELLDAVPRA 1587
+E A P A
Sbjct: 1304 A-EEEAQRATPPA 1315
Score = 47.2 bits (107), Expect = 5e-04
Identities = 112/603 (18%), Positives = 239/603 (39%), Gaps = 48/603 (7%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++++ EK +L + ++++ + EE L A + E+ L +E+
Sbjct: 738 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 797
Query: 288 XXXXXXXLAK--QSIEPSCEEKTEIEEKGSLEIANMTELTKKIE-----LLEHLNCQIRQ 340
+ + Q +E EE+ +K LE KK+E LL L+ Q RQ
Sbjct: 798 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQ-RQ 856
Query: 341 TNKELENKLATMG---TESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQD 397
+ LE K E K +S+ G + R +K S ++ E + Q
Sbjct: 857 SACNLEKKQKKFDQLLAEEKTISA-KYAGERDRAEAEAREKETKALS-LARALEEAMEQK 914
Query: 398 TD-KKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
+ +++NK ++E ++ S KD V K + E + T + +L+ E
Sbjct: 915 AELERLNKQFRTEMEDLMSS--KDDVGKS--VHELEKSKRALEQQVEEMKTQLEELEGEL 970
Query: 457 QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
Q + + V + K Q + + DE + K L+ +++ E +L
Sbjct: 971 QATEDAKLRLEVNL------QAMKAQFERDLQGRDEQSEEKKKQLVRQVREME---AELE 1021
Query: 517 DEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEE 576
DE + + + ++ LK ++ ID+ +K D + I +L + + + EL++
Sbjct: 1022 DERKQRSM-AVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQLRKLQAQMKDCMRELDD 1078
Query: 577 EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQK 636
+ + + L + +MI+++ L A + Q QQ+
Sbjct: 1079 TRASREEILAQAKENEKKLKSMEAEMIQLQE----ELAAAERAKRQA----------QQE 1124
Query: 637 YDEVEDKLADISQLQS----DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
DE+ D++A+ S + ++ E + LEE+++ + + + ++ L +Q+
Sbjct: 1125 RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI 1184
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
+ + + N Q ++N +L KL++M S+ A I E Q +
Sbjct: 1185 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1244
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKA 812
+D + +ER + + K K + ++++ E + ++ + +L ++ ++A
Sbjct: 1245 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1304
Query: 813 YSE 815
E
Sbjct: 1305 EEE 1307
Score = 38.7 bits (86), Expect = 0.17
Identities = 68/333 (20%), Positives = 137/333 (41%), Gaps = 35/333 (10%)
Query: 1285 KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN---QIEILRSEIEDEKVAFXXXXXXX 1341
K+ + QV+ + ++ KEE L ++EK N ++E L+S++ EK+
Sbjct: 697 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQL-QEQLQA 755
Query: 1342 XXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK 1401
+LR + KQ E+ ++ + ++ + + E +
Sbjct: 756 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 815
Query: 1402 VLE---LTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQ---QLVEYEKRIEDLTYEK 1455
+ E +L+L+ K + L + ++ RQ L + +K+ + L E+
Sbjct: 816 LEEEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 875
Query: 1456 E---SELAILRLKMHENANHYET------------MQKESEIERV--KLIEELNVKITES 1498
+ ++ A R + A ET M++++E+ER+ + E+ ++
Sbjct: 876 KTISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 935
Query: 1499 VSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
+ K V EL K+ + EM+T LE E E+ D L+ ++A ++ ++ +
Sbjct: 936 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDL 995
Query: 1559 SFASDTKQGRDEQLDNTMNKELLDAVPRAELDL 1591
QGRDEQ + K+L+ V E +L
Sbjct: 996 -------QGRDEQSEE-KKKQLVRQVREMEAEL 1020
Score = 33.9 bits (74), Expect = 4.9
Identities = 40/161 (24%), Positives = 66/161 (40%), Gaps = 11/161 (6%)
Query: 1447 RIEDLTYEKESELAILRLKMHENANHY---ETMQKESEIERVKLIEELNVKITESVSLNK 1503
R E+ KE EL +R K N ET+Q + E+++L E+L + TE L
Sbjct: 706 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE-TE---LCA 761
Query: 1504 QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
+ EL L AK E++ + E + + +LQ + IQ+ +
Sbjct: 762 EAEELRARL---TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 818
Query: 1564 TKQGRDE-QLDNTMNKELLDAVPRAELDLAMYMLHQRDVRC 1603
+ R + QL+ + L + DL + + HQR C
Sbjct: 819 EESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSAC 859
>AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex protein
1 protein.
Length = 792
Score = 87.0 bits (206), Expect = 5e-16
Identities = 130/585 (22%), Positives = 273/585 (46%), Gaps = 74/585 (12%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVN------------VKDLIEKLKSAEEQITQLNDEID 520
ED +I ++++ K+E+ND+ K V+ +KDL L+ + +++ QL ++
Sbjct: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
Query: 521 AANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
++N+ + ++ H L K+++ + + + K L E+L ++ + +L EEK
Sbjct: 305 LQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQK---ALEEDLQIATKTICQLTEEK- 359
Query: 580 NLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
+ + + + R S V + + +E L T + + E Q L E LQ+
Sbjct: 360 --ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME---LQK 414
Query: 636 KYDEVED--KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY 693
K E+E+ KL + +++ + E+K V E+ + L K+ + E LK +++L
Sbjct: 415 KSSELEEMTKLTNNKEVELE----ELKKVLGEK--ETLLYENKQFEKIAEELKGTEQELI 468
Query: 694 GTIKDLENDKEDIMNKL-------QNYIQENMDLTDKLEKMSAEKISELLAKINH-EEQS 745
G ++ E + D+ +L Q Y +E DL +LE K +EL + N ++
Sbjct: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLEN 527
Query: 746 KIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
K TQ + + L ++N + +++ K + R+ + I +++ L + + +
Sbjct: 528 KELTQ-----ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
L++K+ + +E N L +++ K + E++ ENK L+KK ++
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENK---NKYIEELQQENKALKKKGTA-----ESK 634
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEI 925
Q+++ +++ + L ++ + E T YQ ++ D K+I+ E+ V+K K I
Sbjct: 635 QLNVYEIKVNKLELELESAKQKFGEITDT-YQKEIED-----KKISEENLLEEVEKAKVI 688
Query: 926 ED----LEIEFNTQIESAIRDKKVLNEKYEKNIE-YVTQLEAQLQEYKNNIE---NLNMN 977
D L+ E + + + I + L EK++ + + + +++L YK+ + +L +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRAS 748
Query: 978 VE-ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+E EL+ + EL+ V+KQ + E+ E + A LK+K
Sbjct: 749 LEIELSNLKAELLS--VKKQLEIEREEKEKLKREAKENTATLKEK 791
Score = 74.9 bits (176), Expect = 2e-12
Identities = 142/672 (21%), Positives = 276/672 (41%), Gaps = 65/672 (9%)
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS--NHKLKL-- 537
Q++ K + N +I + K I++L+ E+++ +E NK++IK + H L
Sbjct: 129 QKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
Query: 538 KQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQK-VAELEE-----EKGNLQLHLV---DY 588
+ ++ + K +E ++ +L++ +K + EE E L++H DY
Sbjct: 188 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDY 247
Query: 589 DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
+ + +E + K++ + E L I+ E++ DL L + K +++E+K +
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK----T 303
Query: 649 QLQSDQVCSEI-KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+LQS+ + I K HL ++++ + S + + L+ D + TI L +KE M
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
Query: 708 NKLQNYIQENMDLTDKLEKM--SAEKI--SELLAKINHEEQSKIQTQF--GIDAKIQERD 761
+ + + + E S E++ +E +E+Q KI T ++++E
Sbjct: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYS-----LERKADQLGSYLQEKQKAYSEY 816
N E EL + K + E+ + E++++ L+ +L LQ ++K +
Sbjct: 424 KLTNNKEVELEELKKVLG--EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
IQ + + ++ +L + +N EL L EN+ L SDM
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIE---DLEIEFN 933
E N E K L++ E+ L+ + + QK+ E++ D E
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
Query: 934 TQIESAIRDK-KVLNEKYEKNIEYV---TQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + +K K + E ++N T QL Y+ + L + +E + E+
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNA-------LLKQKDE-------EIIALNQKINNA 1035
D + QK+ E + E+ K L K+ D+ E++AL +K +
Sbjct: 662 DTY-QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 1036 QVS-----------YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQIL 1084
Y S + S A +L N++ E+ V KQL ++ E+L+
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 1085 VREQDDQIKELK 1096
+E +KE K
Sbjct: 781 AKENTATLKEKK 792
Score = 73.3 bits (172), Expect = 6e-12
Identities = 142/672 (21%), Positives = 276/672 (41%), Gaps = 52/672 (7%)
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
EN K+ + Q I++L+ E + KL+ IQEN DL E + + LL +
Sbjct: 136 ENRKIIEAQRKA-IQELQFGNEKVSLKLEEGIQENKDLIK--ENNATRHLCNLLKETCAR 192
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
K + ++ + + + R +Y++ + + + K I EE E+ R + K +
Sbjct: 193 SAEKTK-KYEYERE-ETRQVYMD-LNNNIEK---MITAFEELRVQAENSRLEMHFKLKED 246
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+Q ++ Y + +++ V+ L + + K L + E+++ K NQ LEE
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD--KVNQ--LEEK 302
Query: 863 QNLQ---ISLSDMQQHYNALVEKANRTDLAESESTK--YQTQLRDLESNLKRITHEHQTL 917
LQ + S +QH+ + + L S ST+ + L+ + ++T E +T
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
Query: 918 IVQKKK---EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ + K + EF T + S + ++ EKN + + L +LQ+ + +E +
Sbjct: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+ ++ LE + K + +++T Y + + K+ LK ++E+I L Q
Sbjct: 423 T-KLTNNKEVELEELKKVLGEKETLL--YENK---QFEKIAEELKGTEQELIGLLQ---- 472
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
+ V D E +L TT + +E++ + +L + K N EL + + KE
Sbjct: 473 ---AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE 529
Query: 1095 L-KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK---VQEEEE 1149
L +ET +T E+ + + E M N+ ++ Q+ +E
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ +E L +++ I +L+ N L +Q+N + K+ +L E
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELE 649
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFE----IAELWKQHLAQREADFQKTEHELRVQ----- 1260
++ E+ + ++ + + E+ K + EA + E + R Q
Sbjct: 650 LESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE 709
Query: 1261 LSAFESKYEQLLDSVQSSTQEETNKIVTMEQ-VTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
+ A K++ D + E + EQ +SL+ L E L NL+ + V Q
Sbjct: 710 MVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNLKAELLSVKKQ 766
Query: 1320 IEILRSEIEDEK 1331
+EI R E E K
Sbjct: 767 LEIEREEKEKLK 778
Score = 67.3 bits (157), Expect = 4e-10
Identities = 122/615 (19%), Positives = 256/615 (41%), Gaps = 59/615 (9%)
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALL 1018
Q E++LQE + IE ++EL N E + +++ ++ D ++ N L LL
Sbjct: 129 QKESKLQENRKIIEAQRKAIQELQFGN-EKVSLKLEEGIQENKDLIKEN-NATRHLCNLL 186
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQH 1077
K+ +K + + D + + + T E + + + ++ K+
Sbjct: 187 KETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKED 246
Query: 1078 NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXX 1137
E++Q L +E +I + ++ + I + E + T + +++ +
Sbjct: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF--LLEESRD---------- 294
Query: 1138 XXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQIN 1197
KV + ++E++ LQ ++ K + E Q TK +LE + L V Q+ +
Sbjct: 295 -----KVNQ----LEEKTKLQSENLKQSIEKQHHLTK--ELEDIKVSLQ-RSVSTQKALE 342
Query: 1198 ---QLKSK-LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
Q+ +K + QL E + + + R++ S V + + L ++ L + +K
Sbjct: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL-EELLRTEQQRLEKN 401
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQ-----EETNKIVTMEQVTSLQNKLQDK-EEHLR 1307
E +L++ + K +L + + + EE K++ ++ +NK +K E L+
Sbjct: 402 EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELK 461
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE--NQSYKQMQEQ 1365
++ ++I ++ E+ D ++ DL+TE N+ K +
Sbjct: 462 GTEQ---ELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK-DLKTELENEKLKNTELT 517
Query: 1366 SILN-INEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
S N ++ EN +L + + +N+ + + + LK E Q+T
Sbjct: 518 SHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ-----EERMLKQIENLQETE--- 569
Query: 1425 ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY-ETMQKESEIE 1483
TQ +E E VR++L + ++ + E LR K EN N Y E +Q+E++
Sbjct: 570 ---TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR-KQVENKNKYIEELQQENKAL 625
Query: 1484 RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+ K E + +NK EL A ++ T+ Q +E+++I L +E+
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA 685
Query: 1544 QNMVRASSSKIQKHV 1558
+ ++ + K+QK +
Sbjct: 686 K-VIADEAVKLQKEI 699
Score = 50.8 bits (116), Expect = 4e-05
Identities = 107/575 (18%), Positives = 238/575 (41%), Gaps = 59/575 (10%)
Query: 151 IKEKDNALSVLQVKMKIMETTILDLQEKINE-KDQI--IEAKNKATTXXXXXXXXXXXXX 207
I +K+ +S+L +++ E + DL + E +D++ +E K K +
Sbjct: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL 320
Query: 208 XXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEI 267
ED K + + A+E + + + + + E K+ + +EE+NK A F +
Sbjct: 321 TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ---MEESNKARAAHSFVV 377
Query: 268 SLEHSKLA--QEL---EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMT 322
+ + + +EL EQ + Q EE T++ +E+ +
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
++ + E L + N Q + +EL+ GTE + + + + + +
Sbjct: 438 KVLGEKETLLYENKQFEKIAEELK------GTEQELIGLLQAREKEVHDLEIQLTAITTS 491
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ +S+ + + ++K+ E+ + NK+L + ++ +
Sbjct: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
++ + + Q+E+ Q T T+ NE+ V+E+LKQ+ DE+K
Sbjct: 552 KKQEERMLK-QIENLQE----------TETQLRNELEYVREELKQK-RDEVKC------- 592
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
KL +EE L +++ NK + +++ +K LK +K +++ ++ +L
Sbjct: 593 -KLDKSEENCNNLRKQVENKNKYIEELQQENK-ALK--KKGTAESKQLNVYEIKVNKLEL 648
Query: 563 ELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQ 622
EL QK E+ + + + + ++ E ++ +++ + + +A+ +K ++ +
Sbjct: 649 ELESAKQKFGEITD------TYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKR 702
Query: 623 KFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVI 682
+ E+ L +K+ DK+ + + D KS E+ S+ + L + +
Sbjct: 703 CQHKIAEMVALMEKHKHQYDKIIE----ERDSELGLYKSKEQEQ-----SSLRASLEIEL 753
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQEN 717
NL K +L K LE ++E+ KL+ +EN
Sbjct: 754 SNL---KAELLSVKKQLEIEREE-KEKLKREAKEN 784
>AK091682-1|BAC03719.1| 936|Homo sapiens protein ( Homo sapiens cDNA
FLJ34363 fis, clone FEBRA2015042. ).
Length = 936
Score = 87.0 bits (206), Expect = 5e-16
Identities = 165/815 (20%), Positives = 332/815 (40%), Gaps = 78/815 (9%)
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---ERDLYIENIESE 770
+ + + ++L +M E ++++L ++ E + I+ G K Q ER+L S+
Sbjct: 92 VNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK-RSQ 150
Query: 771 LSKYKSRICRLEESIAVMED---RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
L +S E+ + ++ + L + +L + LQ Q + +L L
Sbjct: 151 LFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTAL 210
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A+ ++ +V++KQL + + L K++ E L + +QQ + LV KA+
Sbjct: 211 AIAENNVQVLQKQLDDAKEGEMALLSKHK---EVESELAAARERLQQQASDLVLKASHIG 267
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
+ ++ + ++DLES R+ L E E + TQ + +++L
Sbjct: 268 MLQATQMTQEVTIKDLESEKSRVNERLSQL------EEERAFLRSKTQSLDEEQKQQILE 321
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
+ + N TQ E +E KN L V +LN+ + + +++ K
Sbjct: 322 LEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNA 381
Query: 1008 INEINKLNA-LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
I + KL L +Q +++ + L + N Q ++ E KL ++ ++++ M R
Sbjct: 382 IRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQD-MVR 440
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDAN 1126
S+Q L S + ++ QD Q + E LT + ++ +T+ +++ E +
Sbjct: 441 KSEQGLGSAEG-----LIASLQDSQERLQNELDLTKD-SLKETKDALLNVEGELEQERQQ 494
Query: 1127 NVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELT 1186
+ + + +EEE ++ + + K L++ +K+ + L E
Sbjct: 495 HEET-----------IAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEED 543
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
++Q + QLK + + N D+ V +L + IS ++++ + L Q
Sbjct: 544 KKSAMSQ--LLQLKDR--EKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS-QTSLQQL 598
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSS------TQEETNKIVTMEQVTSLQNK-- 1298
+A F + L +L E +++Q S++ + T EE + LQ K
Sbjct: 599 QAQFTQERQRLTQELEELEERHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHS 658
Query: 1299 --LQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
LQ K+ H +++ ++ +++ LR E+EDE A DL
Sbjct: 659 AELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRH 718
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSE 1415
N QE + + +L++S R+ D + ++ H + D E
Sbjct: 719 NHH----QELAAAKM-----ELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKE 769
Query: 1416 IYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYET 1475
+ Q HE LT+ +E++ + E L ES I +M E +
Sbjct: 770 V-QHLHENISALTKE-----------LEFKGK-EILRIRSESNQQIRLEEMEE-----KY 811
Query: 1476 MQKESEIERVKLIEELNVKITESVSLNKQVAELNK 1510
+ +ES+ E +++I EL +TE + K++ + K
Sbjct: 812 LMRESKPEDIQMITELKAMLTERDQIIKKLIQKKK 846
Score = 79.8 bits (188), Expect = 7e-14
Identities = 146/775 (18%), Positives = 315/775 (40%), Gaps = 71/775 (9%)
Query: 600 KKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEI 659
+++ E+ E +L++ L+ Q F+ + L L+ ++ ++ + Q D S
Sbjct: 36 REVEEIRRKFEEKLRSFGQLQVQ-FEKDKRL-ALEDLQAAHRREIQELLKSQQDHSASVN 93
Query: 660 KSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD 719
K E++ + + L ++E L+L++++L I+D E +NK Q++ + +D
Sbjct: 94 KGQEKAEELHRMEV--ESLNKMLEELRLERKKL---IEDYEGK----LNKAQSFYERELD 144
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK-IQERDLYIENIESELSKYKSRI 778
+ + +AE + K + + + Q Q I K I + ++ ++ E +
Sbjct: 145 TLKRSQLFTAESLQASKEK-EADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC 203
Query: 779 CRLEESIAVMEDRRYSLERKADQLG----SYLQEKQKAYSEYTIQEDEL----------V 824
+L+ ++A+ E+ L+++ D + L + ++ SE + L
Sbjct: 204 QKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKA 263
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
+ + +L E + ++E E + ++ L EE L+ + + + +
Sbjct: 264 SHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELE 323
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES----AI 940
+ + E++ T+ + R+L++ R+ E L K +E+L + + IE+ AI
Sbjct: 324 KK-VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAI 382
Query: 941 RDKKVLN-EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDKHVQKQQT 998
RDKK L + E++ + LE + + +ENL +E+ LN N E+ H+Q
Sbjct: 383 RDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEI--GHLQDMVR 440
Query: 999 QSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE 1058
+S I L ++ E+ + + + +++ + E + Q +
Sbjct: 441 KSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIA 500
Query: 1059 NM-EEEMQRVSKQLLD-----SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGM 1112
M EEE +V K D ++ +E L E Q +E K++ ++ + + E
Sbjct: 501 AMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 560
Query: 1113 IISSTIEPMSDDA--------NNVDXXXXXXXXXXXXLKVQ---EEEEFIQERSVLQEQS 1161
+ + +D N++ L+ Q E + QE L+E+
Sbjct: 561 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEERH 620
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
+ + L+E + ++ +T+ E + + Q S +L + D ++ R
Sbjct: 621 QQRHKSLKEAH--VLAFQTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHRESMEGFR 676
Query: 1222 SSISSAVDQRGFEIAELWKQHLA--------QREADFQKTEHELRVQLSAFESKYEQLLD 1273
+ + FE+ + K LA Q A H +L+A + + E+ +D
Sbjct: 677 IEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSID 736
Query: 1274 SVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+ ++E +I T LQ +L+ +E H+ L ++ + I L E+E
Sbjct: 737 ISRRQSKEHICRI------TDLQEELRHREHHISELDKEVQHLHENISALTKELE 785
Score = 67.7 bits (158), Expect = 3e-10
Identities = 170/887 (19%), Positives = 370/887 (41%), Gaps = 94/887 (10%)
Query: 461 EGPSLIHVGTNTEDVNEIA-KVQEQLKQELNDEIKDVNVKDL-IEKLKSA-----EEQIT 513
E + + T + +V EI K +E+L+ +++ K L +E L++A +E +
Sbjct: 24 EAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLK 83
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKV-- 571
D + NK K + H+++++ + K ++ ++ K+++ E + +Q
Sbjct: 84 SQQDHSASVNKGQEKAEELHRMEVESLNKMLE---ELRLERKKLIEDYEGKLNKAQSFYE 140
Query: 572 AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAET---RLKA-ISLLESQKFDLV 627
EL+ K + + + E+D+ K+ E + +LK + +++ + L+
Sbjct: 141 RELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLL 200
Query: 628 QELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDA-LSASKKELALVIENLK 686
+ LQ E+ + + + D E+ + +++++ L+A+++ L +L
Sbjct: 201 DKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLV 260
Query: 687 LDKEQL----------YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
L + TIKDLE++K + +L +E L K + + E+ ++L
Sbjct: 261 LKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQIL 320
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
++K Q + +++ +E ++L++ S+ LEE ++
Sbjct: 321 ELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK--TLEELAWKHHMAIEAVH 378
Query: 797 RKADQLGSYLQ---EKQKAYSEYTIQEDELVNRLAVLMDH-DRVVEKQLLEIEHENKELQ 852
A + LQ E+Q + ++ED+ N+L +++ V+E +L E LQ
Sbjct: 379 SNAIRDKKKLQMDLEEQHNKDKLNLEEDK--NQLQQELENLKEVLEDKLNTANQEIGHLQ 436
Query: 853 ---KKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+K++ L + L SL D Q+ N DL + + + L ++E L++
Sbjct: 437 DMVRKSEQGLGSAEGLIASLQDSQERLQ------NELDLTKDSLKETKDALLNVEGELEQ 490
Query: 910 ITHEHQTLIVQKKKE--------IEDLEIEFNTQIE---SAIRDKKVLNEKYEKN--IEY 956
+H+ I K+E DLEI++ + S +R++ L + +K +
Sbjct: 491 ERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQ 550
Query: 957 VTQLE-----AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
+ QL+ A ++ +E+L +N L K NLE+ + + QT Q+ E
Sbjct: 551 LLQLKDREKNAARDSWQKKVEDL-LNQISLLKQNLEI---QLSQSQTSLQQLQAQFTQER 606
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQV-SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
+L L++ +E ++ + A V ++ +M + E + LEN ++ Q
Sbjct: 607 QRLTQELEELEERHQQRHKSLKEAHVLAFQTMEEEKEKE----QRALENHLQQKHSAELQ 662
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
L H E ++ E + +++ L+ FE+ + + M+ S E A +D
Sbjct: 663 SL-KDAHRESMEGFRIEMEQELQTLR-----FELE-DEGKAMLASLRSELNHQHAAAIDL 715
Query: 1131 XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV 1190
K++ E R +E ++ T+LQE ++ E +EL
Sbjct: 716 LRHNHHQELAAAKMELERSIDISRRQSKEHICRI-TDLQE---ELRHREHHISEL----- 766
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADF 1250
+++ L + L E + + +RS + + E L ++ + D
Sbjct: 767 --DKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRE---SKPEDI 821
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQN 1297
Q EL+ L+ + ++L+ + + + TN+ V++ +++L++
Sbjct: 822 QMIT-ELKAMLTERDQIIKKLIQK-KKNDKSPTNRFVSVPNLSALES 866
Score = 66.9 bits (156), Expect = 6e-10
Identities = 152/786 (19%), Positives = 330/786 (41%), Gaps = 64/786 (8%)
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN--LAETRLKAISLLESQKFDLVQEL 630
E++E + Q H + G+ ++++ +E N L E RL+ L+E + L +
Sbjct: 77 EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ 136
Query: 631 HILQQKYDEVEDK---LADISQLQSDQVCSEIKSVHLEEQI--DALSASKKELALVIENL 685
+++ D ++ A+ Q ++ K +E I + K EL +V +
Sbjct: 137 SFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEA 196
Query: 686 K--LDK-EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
LDK ++L + EN+ + + +L + + M L K +++ +E ++ ++ +
Sbjct: 197 GSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESE-LAAARERLQQQ 255
Query: 743 EQSKI--QTQFG-IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
+ + G + A +++ I+++ESE S+ R+ +LEE A + + SL+ +
Sbjct: 256 ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ 315
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN-KELQKKNQIL 858
Q L+ ++K Q++ L L QL E + +EL K+ +
Sbjct: 316 KQ--QILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMA 373
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+E + ++ D ++ L E+ N+ D E K Q Q ++LE NLK + +
Sbjct: 374 IEAVHS--NAIRDKKKLQMDLEEQHNK-DKLNLEEDKNQLQ-QELE-NLKEVLEDKLNTA 428
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
Q+ ++D+ + + SA L + E+ + + L+E K+ + N+ +
Sbjct: 429 NQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGEL 488
Query: 979 EELNKMNLELI----DKHVQKQQTQSPD----YTEQYINEINKLNALLKQKDEE------ 1024
E+ + + E I ++ K + D +TE E +KL L+ + EE
Sbjct: 489 EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAM 548
Query: 1025 --IIALNQKINN-AQVSYMSMVSDYESKLAQFTTKLE----NMEEEMQRVSKQLLDSKQH 1077
++ L + N A+ S+ V D ++++ LE + +Q++ Q +Q
Sbjct: 549 SQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQR 608
Query: 1078 -NEELQILVREQDDQIKELKETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+EL+ L + K LKE L F+ + E + + +
Sbjct: 609 LTQELEELEERHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH 668
Query: 1136 XXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQ 1195
+++ E+E R L+++ + L+ +++ +L H+ + ++
Sbjct: 669 RESMEGFRIEMEQELQTLRFELEDEGKAMLASLR---SELNHQHAAAIDLLRHN--HHQE 723
Query: 1196 INQLKSKLEQ-LNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK--QHLAQ------R 1246
+ K +LE+ ++ + + + + + R I+EL K QHL + +
Sbjct: 724 LAAAKMELERSIDISRRQSKEHICRI-TDLQEELRHREHHISELDKEVQHLHENISALTK 782
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
E +F K + LR++ ES + L+ ++ +K ++ +T L+ L ++++ +
Sbjct: 783 ELEF-KGKEILRIR---SESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQII 838
Query: 1307 RNLQEK 1312
+ L +K
Sbjct: 839 KKLIQK 844
Score = 62.9 bits (146), Expect = 9e-09
Identities = 112/645 (17%), Positives = 259/645 (40%), Gaps = 48/645 (7%)
Query: 913 EHQTLIVQKKKEIEDLEIEFNTQIESA-------IRDKKV-LNEKYEKNIEYVTQLEAQL 964
+H IV +E+E++ +F ++ S +DK++ L + + + +L
Sbjct: 26 QHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQ 85
Query: 965 QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
Q++ ++ EEL++M +E ++K +++ + + E Y ++NK + +++ +
Sbjct: 86 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 145
Query: 1025 I----IALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ---LLDSKQH 1077
+ + + + ++ + +++ + A + ++ E+Q V + LLD Q
Sbjct: 146 LKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQK 205
Query: 1078 NEELQIL----VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
+ + V+ Q+ + KE ++ + E + ++ E + A+++
Sbjct: 206 LQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR-ERLQQQASDLVLKAS 264
Query: 1134 XXXXXXXXLKVQEE--EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVV 1191
QE ++ E+S + E+ ++L E +K ++L+ E +
Sbjct: 265 HIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILE 321
Query: 1192 NQEQINQLK-SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADF 1250
++++N+ K ++ E E NL S + E + ++ A + E+A WK H+A
Sbjct: 322 LEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELA--WKHHMAIEAVHS 379
Query: 1251 QKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQ 1310
+ ++Q+ E + L+ + Q + E + N + HL+++
Sbjct: 380 NAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMV 439
Query: 1311 EKYADVINQIEILRSEIEDEKVAF---XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
K + E L + ++D + ++ E + +Q E++I
Sbjct: 440 RKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETI 499
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ EE +LK + + +L +L L+ E + L
Sbjct: 500 AAMKEEE-KLKVDKMAHDLEIKW----TENLRQECSKLREELRLQHEEDKKSAMS---QL 551
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
Q D +N + ++K++EDL + L +++ ++ + +Q + ER +L
Sbjct: 552 LQLKDREKNAARD--SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRL 609
Query: 1488 IEELNVKITESVSLNKQVAELN----KALEEEVAKTNEMQTALEN 1528
+EL +K + E + + +EEE K Q ALEN
Sbjct: 610 TQELEELEERHQQRHKSLKEAHVLAFQTMEEEKEKE---QRALEN 651
Score = 48.0 bits (109), Expect = 3e-04
Identities = 96/444 (21%), Positives = 182/444 (40%), Gaps = 51/444 (11%)
Query: 1158 QEQSAKLNTELQECYT-KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLST 1216
Q+ SA +N ++ +++E+LN L + ++ I + KL + + + L T
Sbjct: 86 QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDT 145
Query: 1217 VAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
+ + + ++ + A+L K+ Q EA +KT +L+ +L + + LLD Q
Sbjct: 146 LKRSQLFTAESLQASKEKEADLRKEFQGQ-EAILRKTIGKLKTELQMVQDEAGSLLDKCQ 204
Query: 1277 SSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
+T + V LQ +L D +E L K+ E+E E A
Sbjct: 205 KL---QTALAIAENNVQVLQKQLDDAKEGEMALLSKH-----------KEVESELAAARE 250
Query: 1337 XXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN 1396
+ Q+ + QE +I ++ E + RVN
Sbjct: 251 RLQQQASDLVLKASHIGML-QATQMTQEVTIKDLESEKS------------------RVN 291
Query: 1397 DAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKE 1456
+ +++ E L K + ++ + + L ++ +E + +Q+ YE+ +++L E
Sbjct: 292 ERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEY--YERELKNLQSRLE 349
Query: 1457 SELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEV 1516
E+ L + H + IE V + K + L +Q + LEE+
Sbjct: 350 EEVTQLN-EAHSKTLEELAWKHHMAIEAVHS-NAIRDKKKLQMDLEEQHNKDKLNLEED- 406
Query: 1517 AKTNEMQTALENQ----EIEIVTLNDEITNLQNMVRASSSKI---QKHVSFASDTKQGRD 1569
N++Q LEN E ++ T N EI +LQ+MVR S + + ++ D+++
Sbjct: 407 --KNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 464
Query: 1570 EQLDNTMN--KELLDAVPRAELDL 1591
+LD T + KE DA+ E +L
Sbjct: 465 NELDLTKDSLKETKDALLNVEGEL 488
>AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin heavy
chain SM1 protein.
Length = 622
Score = 87.0 bits (206), Expect = 5e-16
Identities = 116/544 (21%), Positives = 241/544 (44%), Gaps = 37/544 (6%)
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+S N ++ ++L + V LEE K Q + + ++ Y K+ + +N
Sbjct: 16 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 75
Query: 610 ETRLKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ-VCSEIKSVHLEEQ 667
+ L + + L++Q+ LV L Q+K+D++ + +IS +D+ +E ++ E +
Sbjct: 76 QQELDDLVVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 134
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+L+ + +E E L+ + L ++DL + K+D+ + + L ++E+M
Sbjct: 135 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 194
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDA-KIQ-ERDLYIENIESELSKYKSRICRLEESI 785
+ + EL ++ E +K++ + + A K Q ERDL + ++E K + +L E
Sbjct: 195 KTQ-LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYE 252
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKA-YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ED ERK L + ++K + + +Q D + + H R ++ Q+ +
Sbjct: 253 TELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDF 307
Query: 845 EHENKELQ-KKNQIL--LEENQNLQISL-SDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E ++ + +++I +EN+ SL +D+ Q L A+ E + +L
Sbjct: 308 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 367
Query: 901 RDLESNLKRITHEHQTL---IVQKKKEIEDLE--IE-FNTQIESAIRDKKVLNEKY---- 950
S + E + L I Q ++E+E+ + +E + ++ A + + L+ +
Sbjct: 368 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 427
Query: 951 ---EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
+KN QLE Q +E ++ + + V+ K + ++ + + + Q EQ
Sbjct: 428 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQE 483
Query: 1008 INEINKLNALLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
E LKQKD +EI+ + Y +++ Q +LE EEE
Sbjct: 484 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 543
Query: 1065 QRVS 1068
QR++
Sbjct: 544 QRIN 547
Score = 82.6 bits (195), Expect = 1e-14
Identities = 94/531 (17%), Positives = 230/531 (43%), Gaps = 26/531 (4%)
Query: 576 EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
E K NL+ H+ + + SD KK+ + + E + + + +L Q+
Sbjct: 7 EAKQNLERHISTLN---IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 63
Query: 636 KYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKL----DKEQ 691
YD++E + Q D V L ++ +L +N+ ++++
Sbjct: 64 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 123
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQ--ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
++ E + L+ ++ E ++ T+K+ K E + + ++
Sbjct: 124 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 183
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQE 808
+ ++ +++E +E +E EL + RLE ++ ++ + L+ + +Q ++
Sbjct: 184 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 243
Query: 809 KQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
Q+ EY + EDE R A+ + +E L ++E + K + ++ + LQ
Sbjct: 244 LQRQLHEYETELEDERKQR-ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQA 302
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
+ D Q+ +A+R ++ + + + + + + LE++L ++ + ++ ++ D
Sbjct: 303 QMKDFQRELEDA--RASRDEIFAT-AKENEKKAKSLEADLMQL--QEDLAAAERARKQAD 357
Query: 928 LEIE-FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
LE E ++ S++ + L ++ + + QLE +L+E + N+E ++ V + +
Sbjct: 358 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 417
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+L ++ ++ T + E ++ + N L+ K L++ + + S ++
Sbjct: 418 QLSNELATERSTAQKN--ESARQQLERQNKELRSK------LHEMEGAVKSKFKSTIAAL 469
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
E+K+AQ ++E E Q +K L + +E+ + V ++ ++ KE
Sbjct: 470 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 520
Score = 74.9 bits (176), Expect = 2e-12
Identities = 100/582 (17%), Positives = 248/582 (42%), Gaps = 37/582 (6%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLENDKEDIMNKLQNYIQ---EN 717
L E+++A ++ ++ + L K++L T++ LE K+ +++N Q E
Sbjct: 2 LNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 61
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 62 AAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 120
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVL 830
R E E + SL R ++ +E ++ + ++LV+ + L
Sbjct: 121 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 180
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E
Sbjct: 181 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNE 238
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ + Q QL + E+ L+ + KKK DL+ + Q +SAI+ +
Sbjct: 239 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGR------- 290
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
E+ I++V +L+AQ+++++ +E+ + +E+ ++ +K ++ D Q +
Sbjct: 291 EEAIKHVRKLQAQMKDFQRELEDARASRDEI----FATAKENEKKAKSLEADLM-QLQED 345
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRV 1067
+ KQ D E L +++ ++ ++ + E+++AQ +LE + M+ +
Sbjct: 346 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 405
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S ++ + Q E+L + + ++ + + E + + S + M +
Sbjct: 406 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-----QNKELRSKLHEMEGAVKS 460
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
++ E+ +E+ + + + +L+E ++ + +
Sbjct: 461 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 520
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ QLK +LE+ E+ + + +L+ + A +
Sbjct: 521 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 562
Score = 73.3 bits (172), Expect = 6e-12
Identities = 120/593 (20%), Positives = 253/593 (42%), Gaps = 47/593 (7%)
Query: 323 ELTKKIELLEH---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA 379
E+ K L H LN Q+ + K+L++ +T+ + K+ L + + A
Sbjct: 5 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 64
Query: 380 -SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
K++ ++L E + D + ++ LE + ++ L +++ + S+
Sbjct: 65 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 124
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVN 497
K+T L ++ +E + E N++ K + E L +D K+V+
Sbjct: 125 EAEAREKETKALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVH 178
Query: 498 VKD-----LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+ L +++ + Q+ +L DE+ A ++++ N + Q ++ + + ++
Sbjct: 179 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 238
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR 612
+ +L +LH ELE+E+ L + + +E D+ ++ ++ + R
Sbjct: 239 EKRR--QLQRQLHEYE---TELEDERKQRALAAA---AKKKLEGDLKDLELQADSAIKGR 290
Query: 613 ---LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
+K + L++Q D +EL + DE+ A + + E + L+E +
Sbjct: 291 EEAIKHVRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLA 347
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTD 722
A ++K+ L E L + L+++K + + +L+ ++E NM+ ++D
Sbjct: 348 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 407
Query: 723 KLEKMS--AEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRIC 779
++ K + AE++S LA Q + ++ + +E + +E + SK+KS I
Sbjct: 408 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 467
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HD 834
LE IA +E++ R+ L++K K E +Q EDE + + + +
Sbjct: 468 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 527
Query: 835 RV--VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
RV +++QL E E E++ + + L E S M + NAL K R
Sbjct: 528 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 580
Score = 64.1 bits (149), Expect = 4e-09
Identities = 99/518 (19%), Positives = 227/518 (43%), Gaps = 38/518 (7%)
Query: 476 NEIAKVQEQLKQELNDEIKDV-NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
+++ K + +L+QEL+D + D+ N + L+ L+ + + QL E + + +
Sbjct: 66 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 125
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH-LSQKVAELEEEKGNLQLHLVDYD-SGR 592
+ ++ + + ++ + E E + L ++ +L K ++ ++ + + S R
Sbjct: 126 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 185
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD---EVEDKLADISQ 649
+E+ + + ++E L E L+A E K L + L+ +++ + D+ + +
Sbjct: 186 ALETQMEEMKTQLEEL-EDELQAT---EDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 241
Query: 650 LQSDQVCSEIKSVHLEE--QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
Q + E ++ +E Q +A+KK+L +++L+L + ++ +
Sbjct: 242 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQ 301
Query: 708 NKLQNYIQENMDLTDKLEKMSAE-KISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIE 765
+++++ +E D +++ A K +E AK + ++Q + +++ DL E
Sbjct: 302 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 361
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ EL+ S L++ +E R LE + ++ ++ + T Q ++L N
Sbjct: 362 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 421
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
LA + E ++E +NKEL+ K L +M+ V+ +
Sbjct: 422 ELATERSTAQKNESARQQLERQNKELRSK--------------LHEME----GAVKSKFK 463
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
+ +A E+ ++ LE +++ E Q K++ + L+ E Q+E + +
Sbjct: 464 STIAALEA-----KIAQLEEQVEQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQ 517
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
E+ EK V QL+ QL+E + + +N N +L +
Sbjct: 518 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 555
Score = 62.1 bits (144), Expect = 2e-08
Identities = 86/541 (15%), Positives = 213/541 (39%), Gaps = 32/541 (5%)
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV---LNEKYEKNIEYVT 958
+ + NL+R + KK+++D E R +K L ++YE+
Sbjct: 7 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 66
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+LE + +++L ++++ ++ NLE + + + + + +Y +E ++ A
Sbjct: 67 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 126
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRVSKQLLD 1073
++K+ + ++L + + A + + ++++ + +++ + + + K
Sbjct: 127 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 186
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
+ EE++ + E +D+++ ++ KL E+N+ +G D+ N
Sbjct: 187 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL--QARDEQNEEKRRQL 244
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
++++E ++R++ KL +L++ + E H Q
Sbjct: 245 QRQLHEYETELEDER---KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQ 301
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISS------------AVDQRGFEIAELWKQ 1241
Q+ + +LE D + +T E S A +R + A+L K+
Sbjct: 302 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 361
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQL---LDSVQSSTQEETNKI-VTMEQVTSLQN 1297
LA+ A + L+ + E++ QL L+ Q + + ++++ +Q L N
Sbjct: 362 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 421
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
+L + + + + Q + LRS++ + + A L + +
Sbjct: 422 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 481
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE---AKVLELTHQLELKDS 1414
+ ++ + ++ +++ +LK+ AE A+V +L QLE +
Sbjct: 482 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 541
Query: 1415 E 1415
E
Sbjct: 542 E 542
Score = 48.4 bits (110), Expect = 2e-04
Identities = 95/530 (17%), Positives = 220/530 (41%), Gaps = 35/530 (6%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELENKLATMGTES 356
Q + E E +++ EI N+T+ +K + L + +EL++ + + +
Sbjct: 31 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 90
Query: 357 KAVSSPSKKGSPLISRKSG-RNTASKMKSPWSQLSSETLNQDTDKKINK----NEIAKLE 411
+ VS+ KK + +N +SK + +E ++T K ++ E + +
Sbjct: 91 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET-KALSLARALEEALEAK 149
Query: 412 MVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
++ NK L + E ++S KD K L Q++ Q E +
Sbjct: 150 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA-- 207
Query: 471 NTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEI-DAANKNMIK 528
TED +V Q LK + +++ + ++ EK + + Q+ + E+ D + +
Sbjct: 208 -TEDAKLRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERKQRALA 265
Query: 529 VKSNHKLK--LKQMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL 585
+ KL+ LK ++ D+ K ++ K + +L ++ +++ + + +
Sbjct: 266 AAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDFQRELEDARASRDEIFATA 325
Query: 586 VDYDS-GRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + + +E+D+ M E+LA +A + +K +L +EL L
Sbjct: 326 KENEKKAKSLEADL---MQLQEDLAAAE-RARKQADLEKEELAEEL----------ASSL 371
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ + LQ ++ E + LEE+++ + + ++ + EQL + + +
Sbjct: 372 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 431
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
+ Q ++N +L KL +M S+ + I E Q + ++ + +E+
Sbjct: 432 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 491
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLER---KADQLGSYLQEKQK 811
++++ + K K + ++E+ + E + E+ + QL L+E ++
Sbjct: 492 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 541
Score = 33.9 bits (74), Expect = 4.9
Identities = 65/311 (20%), Positives = 117/311 (37%), Gaps = 25/311 (8%)
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
QL + +++ E + Q++ + KLQD + L+E +IE L + E
Sbjct: 1 QLNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE- 59
Query: 1330 EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXX 1386
EK A DL + + +Q+ E+ ++ A+ K S
Sbjct: 60 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 119
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ E K L L LE E + E T E E++ + K
Sbjct: 120 ERDRAEAEAREKETKALSLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGK 175
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQV 1505
+ +L K + L +M E E ++ E + E KL E+N++ + +
Sbjct: 176 NVHELEKSKRA----LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFE 227
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFAS 1562
+L E+ K ++Q L E E L DE + + A+ K++ K + +
Sbjct: 228 RDLQARDEQNEEKRRQLQRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQA 283
Query: 1563 DTK-QGRDEQL 1572
D+ +GR+E +
Sbjct: 284 DSAIKGREEAI 294
>AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin heavy
chain SM2 protein.
Length = 588
Score = 87.0 bits (206), Expect = 5e-16
Identities = 116/544 (21%), Positives = 241/544 (44%), Gaps = 37/544 (6%)
Query: 550 VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLA 609
+S N ++ ++L + V LEE K Q + + ++ Y K+ + +N
Sbjct: 16 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 75
Query: 610 ETRLKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ-VCSEIKSVHLEEQ 667
+ L + + L++Q+ LV L Q+K+D++ + +IS +D+ +E ++ E +
Sbjct: 76 QQELDDLVVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 134
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
+L+ + +E E L+ + L ++DL + K+D+ + + L ++E+M
Sbjct: 135 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 194
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDA-KIQ-ERDLYIENIESELSKYKSRICRLEESI 785
+ + EL ++ E +K++ + + A K Q ERDL + ++E K + +L E
Sbjct: 195 KTQ-LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYE 252
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKA-YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+ED ERK L + ++K + + +Q D + + H R ++ Q+ +
Sbjct: 253 TELED-----ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDF 307
Query: 845 EHENKELQ-KKNQIL--LEENQNLQISL-SDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ E ++ + +++I +EN+ SL +D+ Q L A+ E + +L
Sbjct: 308 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 367
Query: 901 RDLESNLKRITHEHQTL---IVQKKKEIEDLE--IE-FNTQIESAIRDKKVLNEKY---- 950
S + E + L I Q ++E+E+ + +E + ++ A + + L+ +
Sbjct: 368 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 427
Query: 951 ---EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
+KN QLE Q +E ++ + + V+ K + ++ + + + Q EQ
Sbjct: 428 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ----VEQE 483
Query: 1008 INEINKLNALLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEM 1064
E LKQKD +EI+ + Y +++ Q +LE EEE
Sbjct: 484 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 543
Query: 1065 QRVS 1068
QR++
Sbjct: 544 QRIN 547
Score = 82.6 bits (195), Expect = 1e-14
Identities = 94/531 (17%), Positives = 230/531 (43%), Gaps = 26/531 (4%)
Query: 576 EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
E K NL+ H+ + + SD KK+ + + E + + + +L Q+
Sbjct: 7 EAKQNLERHISTLN---IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 63
Query: 636 KYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKL----DKEQ 691
YD++E + Q D V L ++ +L +N+ ++++
Sbjct: 64 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 123
Query: 692 LYGTIKDLENDKEDIMNKLQNYIQ--ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
++ E + L+ ++ E ++ T+K+ K E + + ++
Sbjct: 124 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 183
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDR-RYSLERKADQLGSYLQE 808
+ ++ +++E +E +E EL + RLE ++ ++ + L+ + +Q ++
Sbjct: 184 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 243
Query: 809 KQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQI 867
Q+ EY + EDE R A+ + +E L ++E + K + ++ + LQ
Sbjct: 244 LQRQLHEYETELEDERKQR-ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQA 302
Query: 868 SLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIED 927
+ D Q+ +A+R ++ + + + + + + LE++L ++ + ++ ++ D
Sbjct: 303 QMKDFQRELEDA--RASRDEIFAT-AKENEKKAKSLEADLMQL--QEDLAAAERARKQAD 357
Query: 928 LEIE-FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNL 986
LE E ++ S++ + L ++ + + QLE +L+E + N+E ++ V + +
Sbjct: 358 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 417
Query: 987 ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDY 1046
+L ++ ++ T + E ++ + N L+ K L++ + + S ++
Sbjct: 418 QLSNELATERSTAQKN--ESARQQLERQNKELRSK------LHEMEGAVKSKFKSTIAAL 469
Query: 1047 ESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
E+K+AQ ++E E Q +K L + +E+ + V ++ ++ KE
Sbjct: 470 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 520
Score = 74.9 bits (176), Expect = 2e-12
Identities = 100/582 (17%), Positives = 248/582 (42%), Gaps = 37/582 (6%)
Query: 664 LEEQIDALSASKKELALVIENLKLDKEQLY---GTIKDLENDKEDIMNKLQNYIQ---EN 717
L E+++A ++ ++ + L K++L T++ LE K+ +++N Q E
Sbjct: 2 LNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 61
Query: 718 MDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSR 777
DKLEK + ++ + L + + ++ Q ++ K ++ D + ++ SKY
Sbjct: 62 AAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 120
Query: 778 ICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN-------RLAVL 830
R E E + SL R ++ +E ++ + ++LV+ + L
Sbjct: 121 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 180
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
R +E Q+ E++ + +EL+ + Q + L++++ ++ + ++ R + E
Sbjct: 181 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA--RDEQNE 238
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ + Q QL + E+ L+ + KKK DL+ + Q +SAI+ +
Sbjct: 239 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGR------- 290
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
E+ I++V +L+AQ+++++ +E+ + +E+ ++ +K ++ D Q +
Sbjct: 291 EEAIKHVRKLQAQMKDFQRELEDARASRDEI----FATAKENEKKAKSLEADLM-QLQED 345
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRV 1067
+ KQ D E L +++ ++ ++ + E+++AQ +LE + M+ +
Sbjct: 346 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 405
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
S ++ + Q E+L + + ++ + + E + + S + M +
Sbjct: 406 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-----QNKELRSKLHEMEGAVKS 460
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
++ E+ +E+ + + + +L+E ++ + +
Sbjct: 461 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 520
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
++ QLK +LE+ E+ + + +L+ + A +
Sbjct: 521 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 562
Score = 71.7 bits (168), Expect = 2e-11
Identities = 119/590 (20%), Positives = 252/590 (42%), Gaps = 47/590 (7%)
Query: 323 ELTKKIELLEH---LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA 379
E+ K L H LN Q+ + K+L++ +T+ + K+ L + + A
Sbjct: 5 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 64
Query: 380 -SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
K++ ++L E + D + ++ LE + ++ L +++ + S+
Sbjct: 65 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 124
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQ-EQLKQELNDEIKDVN 497
K+T L ++ +E + E N++ K + E L +D K+V+
Sbjct: 125 EAEAREKETKALSLARALEEALEAKEEL------ERTNKMLKAEMEDLVSSKDDVGKNVH 178
Query: 498 VKD-----LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+ L +++ + Q+ +L DE+ A ++++ N + Q ++ + + ++
Sbjct: 179 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 238
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETR 612
+ +L +LH ELE+E+ L + + +E D+ ++ ++ + R
Sbjct: 239 EKRR--QLQRQLHEYE---TELEDERKQRALAAA---AKKKLEGDLKDLELQADSAIKGR 290
Query: 613 ---LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
+K + L++Q D +EL + DE+ A + + E + L+E +
Sbjct: 291 EEAIKHVRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLA 347
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI---MNKLQNYIQE---NMD-LTD 722
A ++K+ L E L + L+++K + + +L+ ++E NM+ ++D
Sbjct: 348 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 407
Query: 723 KLEKMS--AEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL-SKYKSRIC 779
++ K + AE++S LA Q + ++ + +E + +E + SK+KS I
Sbjct: 408 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 467
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQ-EDE--LVNRLAVLMD--HD 834
LE IA +E++ R+ L++K K E +Q EDE + + + +
Sbjct: 468 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 527
Query: 835 RV--VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK 882
RV +++QL E E E++ + + L E S M + NAL K
Sbjct: 528 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 577
Score = 64.1 bits (149), Expect = 4e-09
Identities = 99/518 (19%), Positives = 227/518 (43%), Gaps = 38/518 (7%)
Query: 476 NEIAKVQEQLKQELNDEIKDV-NVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
+++ K + +L+QEL+D + D+ N + L+ L+ + + QL E + + +
Sbjct: 66 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 125
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH-LSQKVAELEEEKGNLQLHLVDYD-SGR 592
+ ++ + + ++ + E E + L ++ +L K ++ ++ + + S R
Sbjct: 126 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 185
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD---EVEDKLADISQ 649
+E+ + + ++E L E L+A E K L + L+ +++ + D+ + +
Sbjct: 186 ALETQMEEMKTQLEEL-EDELQAT---EDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 241
Query: 650 LQSDQVCSEIKSVHLEE--QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
Q + E ++ +E Q +A+KK+L +++L+L + ++ +
Sbjct: 242 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQ 301
Query: 708 NKLQNYIQENMDLTDKLEKMSAE-KISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIE 765
+++++ +E D +++ A K +E AK + ++Q + +++ DL E
Sbjct: 302 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 361
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
+ EL+ S L++ +E R LE + ++ ++ + T Q ++L N
Sbjct: 362 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 421
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
LA + E ++E +NKEL+ K L +M+ V+ +
Sbjct: 422 ELATERSTAQKNESARQQLERQNKELRSK--------------LHEME----GAVKSKFK 463
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
+ +A E+ ++ LE +++ E Q K++ + L+ E Q+E + +
Sbjct: 464 STIAALEA-----KIAQLEEQVEQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQ 517
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
E+ EK V QL+ QL+E + + +N N +L +
Sbjct: 518 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 555
Score = 62.1 bits (144), Expect = 2e-08
Identities = 86/541 (15%), Positives = 213/541 (39%), Gaps = 32/541 (5%)
Query: 902 DLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV---LNEKYEKNIEYVT 958
+ + NL+R + KK+++D E R +K L ++YE+
Sbjct: 7 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 66
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNA 1016
+LE + +++L ++++ ++ NLE + + + + + +Y +E ++ A
Sbjct: 67 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 126
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRVSKQLLD 1073
++K+ + ++L + + A + + ++++ + +++ + + + K
Sbjct: 127 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 186
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
+ EE++ + E +D+++ ++ KL E+N+ +G D+ N
Sbjct: 187 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL--QARDEQNEEKRRQL 244
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQ 1193
++++E ++R++ KL +L++ + E H Q
Sbjct: 245 QRQLHEYETELEDER---KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQ 301
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISS------------AVDQRGFEIAELWKQ 1241
Q+ + +LE D + +T E S A +R + A+L K+
Sbjct: 302 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 361
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQL---LDSVQSSTQEETNKI-VTMEQVTSLQN 1297
LA+ A + L+ + E++ QL L+ Q + + ++++ +Q L N
Sbjct: 362 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 421
Query: 1298 KLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQ 1357
+L + + + + Q + LRS++ + + A L + +
Sbjct: 422 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 481
Query: 1358 SYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAE---AKVLELTHQLELKDS 1414
+ ++ + ++ +++ +LK+ AE A+V +L QLE +
Sbjct: 482 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 541
Query: 1415 E 1415
E
Sbjct: 542 E 542
Score = 48.4 bits (110), Expect = 2e-04
Identities = 95/530 (17%), Positives = 220/530 (41%), Gaps = 35/530 (6%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELENKLATMGTES 356
Q + E E +++ EI N+T+ +K + L + +EL++ + + +
Sbjct: 31 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 90
Query: 357 KAVSSPSKKGSPLISRKSG-RNTASKMKSPWSQLSSETLNQDTDKKINK----NEIAKLE 411
+ VS+ KK + +N +SK + +E ++T K ++ E + +
Sbjct: 91 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET-KALSLARALEEALEAK 149
Query: 412 MVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
++ NK L + E ++S KD K L Q++ Q E +
Sbjct: 150 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA-- 207
Query: 471 NTEDVNEIAKVQEQ-LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEI-DAANKNMIK 528
TED +V Q LK + +++ + ++ EK + + Q+ + E+ D + +
Sbjct: 208 -TEDAKLRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERKQRALA 265
Query: 529 VKSNHKLK--LKQMQKTIDNFSKV-SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL 585
+ KL+ LK ++ D+ K ++ K + +L ++ +++ + + +
Sbjct: 266 AAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDFQRELEDARASRDEIFATA 325
Query: 586 VDYDS-GRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKL 644
+ + + +E+D+ M E+LA +A + +K +L +EL L
Sbjct: 326 KENEKKAKSLEADL---MQLQEDLAAAE-RARKQADLEKEELAEEL----------ASSL 371
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKE 704
+ + LQ ++ E + LEE+++ + + ++ + EQL + + +
Sbjct: 372 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 431
Query: 705 DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYI 764
+ Q ++N +L KL +M S+ + I E Q + ++ + +E+
Sbjct: 432 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 491
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLER---KADQLGSYLQEKQK 811
++++ + K K + ++E+ + E + E+ + QL L+E ++
Sbjct: 492 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 541
Score = 33.9 bits (74), Expect = 4.9
Identities = 65/311 (20%), Positives = 117/311 (37%), Gaps = 25/311 (8%)
Query: 1270 QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIED 1329
QL + +++ E + Q++ + KLQD + L+E +IE L + E
Sbjct: 1 QLNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE- 59
Query: 1330 EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM---QEQSILNINEENAQLKKSSXXXXX 1386
EK A DL + + +Q+ E+ ++ A+ K S
Sbjct: 60 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 119
Query: 1387 XXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEK 1446
+ E K L L LE E + E T E E++ + K
Sbjct: 120 ERDRAEAEAREKETKALSLARALE----EALEAKEELERTNKMLKAEMEDLVSSKDDVGK 175
Query: 1447 RIEDLTYEKESELAILRLKMHENANHYETMQKESE-IERVKLIEELNVKITESVSLNKQV 1505
+ +L K + L +M E E ++ E + E KL E+N++ + +
Sbjct: 176 NVHELEKSKRA----LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK----GQFE 227
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQ---KHVSFAS 1562
+L E+ K ++Q L E E L DE + + A+ K++ K + +
Sbjct: 228 RDLQARDEQNEEKRRQLQRQLHEYETE---LEDE-RKQRALAAAAKKKLEGDLKDLELQA 283
Query: 1563 DTK-QGRDEQL 1572
D+ +GR+E +
Sbjct: 284 DSAIKGREEAI 294
>U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase p160ROCK protein.
Length = 1354
Score = 86.6 bits (205), Expect = 7e-16
Identities = 129/599 (21%), Positives = 267/599 (44%), Gaps = 67/599 (11%)
Query: 468 VGTNTEDVNE-IAKVQEQLKQELNDEIKD-----VNVKDLIEKLKSAEEQITQLNDEIDA 521
V N++ NE ++++Q+QL +E ND ++ V ++ ++ + Q+ LN E+
Sbjct: 529 VSQNSQLANEKLSQLQKQL-EEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQE 587
Query: 522 ANKNMIKVKSNHKLKLKQMQKTID--------NFSKVSDSNKEIVRLTEELHHLSQKVAE 573
N+ + KS Q+Q ++ + + D I L EE+ HL + +
Sbjct: 588 RNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEK 647
Query: 574 LEEEKGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
+E E+ Q L + + +E D+ K+ ++ E + + +++ D Q +
Sbjct: 648 VEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEE 707
Query: 633 LQQ-KYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
+ E+E KL + + + +E + V +E+Q L K+ +E+L +KE+
Sbjct: 708 AKSVAMCEMEKKLKEEREAREK---AENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKER 764
Query: 692 LYGTIKDLENDKEDIMNK---LQNYIQENMDLTDK---LEKMSAEKISELL--AKINHEE 743
+ +K+L E NK LQN ++ D LEK ++I+ LL ++ E
Sbjct: 765 MEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFE 824
Query: 744 QSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQL 802
+++ Q+ G + +++E +E + + YK+++ L+E I E R +L++
Sbjct: 825 LAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIE--EKNRENLKK----- 877
Query: 803 GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
+QE Q Q D + ++E+Q E+ E+K+ +N+ +E
Sbjct: 878 ---IQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNR---QE- 930
Query: 863 QNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK 922
++D + H + +E+AN + E + + + +L +K+ E++ ++K+
Sbjct: 931 ------ITD-KDHTVSRLEEANSMLTKDIEILRRENE--ELTEKMKKAEEEYK---LEKE 978
Query: 923 KEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELN 982
+EI +L+ F I + ++ + + K E + + + ++ K N ++L +E
Sbjct: 979 EEISNLKAAFEKNINT---ERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENR 1035
Query: 983 KMNLEL------IDKHVQKQQTQSPDYTEQYINEI---NKLNALLKQKDEEIIALNQKI 1032
K+ LEL ++ V K Q + D Q + E N+L L K+ +I L K+
Sbjct: 1036 KLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 81.0 bits (191), Expect = 3e-14
Identities = 129/680 (18%), Positives = 292/680 (42%), Gaps = 60/680 (8%)
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
L+++I +E++ ++ + D++ + + + DE N+ L +EK+
Sbjct: 428 LQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKE 487
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQL 900
+ ++H E Q+K + E+ +N++ +S ++ L + + + LA + ++ Q QL
Sbjct: 488 KMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQL 547
Query: 901 RDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV 957
+ L+ + L + K I LE N +++ R++ + N K + + +Y
Sbjct: 548 EEANDLLRTESDTAVRLRKSHTEMSKSISQLE-SLNRELQE--RNRILENSKSQTDKDYY 604
Query: 958 TQLEAQLQEYKNN-------IENLNMNVEELN------KMNLELIDKHVQKQQTQSPDYT 1004
QL+A L+ + + I +L + L K NLE ++ +K+ +++
Sbjct: 605 -QLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGE-RKEAQDMLNHS 662
Query: 1005 EQYINEIN-----KLNALLKQKDEEI-------IALNQKINNAQVSYMSMVSDYESKLAQ 1052
E+ N + KL +L ++ ++E+ L K + + + + + E KL +
Sbjct: 663 EKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKE 722
Query: 1053 FTTKLENMEEEMQRVSKQL----LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
E E + ++ KQ +D KQ ++L+ L ++ E+K LT ++
Sbjct: 723 EREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVK--NLTLQLEQES 780
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL----KVQEEE--EFIQERSVLQEQSA 1162
+ +++ + ++ + +A+N+ L ++ E E + ++ + Q
Sbjct: 781 NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR 840
Query: 1163 KLNTELQ-ECYTKII---QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
+L +L+ E Y + Q++ L E+ + N ++I +L+++ E L T+ D L T A
Sbjct: 841 ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD-LAETKA 899
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
E ++++ FE+ + K+ ++ + +H + +L S + ++ ++
Sbjct: 900 ESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVS-RLEEANSMLTKDIEILRRE 958
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+E T K+ E+ L +KEE + NL+ + IN L+++ ++
Sbjct: 959 NEELTEKMKKAEEEYKL-----EKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRK 1013
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DLR + + +++Q L +N+E + + ++ +
Sbjct: 1014 DFKIDRKKANTQDLRKKEKENRKLQ----LELNQEREKFNQMVVKHQKELNDMQAQLVEE 1069
Query: 1399 EAKVLELTHQLELKDSEIYQ 1418
A EL QL K+S+I Q
Sbjct: 1070 CAHRNELQMQLASKESDIEQ 1089
Score = 80.2 bits (189), Expect = 6e-14
Identities = 138/724 (19%), Positives = 307/724 (42%), Gaps = 54/724 (7%)
Query: 389 LSSETLNQD-TDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDT 447
LSS N + T +K+ L+ I L + L ++ + KD D
Sbjct: 406 LSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQL---KDEMEQKCRTSNIKLDK 462
Query: 448 LIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKS 507
++ +L E Q S + + + + + Q K E +E K NV++ + LK
Sbjct: 463 IMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENE-KRRNVENEVSTLKD 521
Query: 508 AEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHL 567
E + +++ AN+ + +++ KQ+++ D SD+ VRL + +
Sbjct: 522 QLEDLKKVSQNSQLANEKLSQLQ-------KQLEEANDLLRTESDT---AVRLRKSHTEM 571
Query: 568 SQKVAELEEEKGNLQ-LHLVDYDSGRMIESDVYKKMIEMENLAETR---LKAISLLESQK 623
S+ +++LE LQ + + +S + D Y+ +E R + I L+++
Sbjct: 572 SKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARI 631
Query: 624 FDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID-ALSASKKELALVI 682
L +E+ L+ ++VE + + + + SE + +LE ++ L + ++ L +
Sbjct: 632 TSLQEEVKHLKHNLEKVEGERKEAQDMLNH---SEKEKNNLEIDLNYKLKSLQQRLEQEV 688
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK--MSAEKISELLAKIN 740
K+ K +L + +E K M +++ ++E + +K E + EK +L
Sbjct: 689 NEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDL 748
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESI---AVMEDRRYSLER 797
+ Q K++ G ++++ ++N+ +L + ++ L+ + A D LE+
Sbjct: 749 KQSQQKLEHLTGNKERMEDE---VKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEK 805
Query: 798 KADQ-LGSYLQEKQKAYSEYT-IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
+ Q + + L+ K+ E + + N + D++ +Q ++ + + K
Sbjct: 806 QMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKE 865
Query: 856 QILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
+I + +NL+ + ++Q L A + DLAE+++ Q LE +T E +
Sbjct: 866 EIEEKNRENLK-KIQELQNEKETL---ATQLDLAETKAESEQLARGLLEEQYFELTQESK 921
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
+ ++EI D + + E+ K + +N E +++ +EYK E
Sbjct: 922 KAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKE--- 978
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEI---IALNQKI 1032
EE++ + +K++ ++T +NKL ++ +KD +I A Q +
Sbjct: 979 ---EEISNLK-AAFEKNINTERTLK-------TQAVNKLAEIMNRKDFKIDRKKANTQDL 1027
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI 1092
+ + + + +F + ++E+ + QL++ H ELQ+ + ++ I
Sbjct: 1028 RKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDI 1087
Query: 1093 KELK 1096
++L+
Sbjct: 1088 EQLR 1091
Score = 74.1 bits (174), Expect = 4e-12
Identities = 126/625 (20%), Positives = 273/625 (43%), Gaps = 43/625 (6%)
Query: 297 KQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTES 356
++ E E++ +E + S + +L K + + N ++ Q K+LE + TES
Sbjct: 499 QRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTES 558
Query: 357 KAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS 416
K S + S+++S +L + K + +L+ ++++
Sbjct: 559 DTAVRLRK------SHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEA 612
Query: 417 LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQ--QHMEGPSLIHVGTNTED 474
+D +I + + +++ E + Q M S D
Sbjct: 613 ERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEID 672
Query: 475 VN-EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
+N ++ +Q++L+QE+N+ V L +K +S EE + E++ K+K
Sbjct: 673 LNYKLKSLQQRLEQEVNEH--KVTKARLTDKHQSIEEAKSVAMCEMEK------KLKEER 724
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR- 592
+ + K + + + S + ++ + ++L HL+ +E+E NL L L + R
Sbjct: 725 EAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRL 784
Query: 593 MIESDVYKKMIEMENL--AETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADI-S 648
++++++ + E +NL E ++K I+ L K L EL L ++Y E ++ ++
Sbjct: 785 LLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQD 844
Query: 649 QLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMN 708
QL+++Q S + ++E + + +E I+ L+ +KE L T DL K +
Sbjct: 845 QLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETL-ATQLDLAETKAESEQ 903
Query: 709 KLQNYIQEN-MDLTDKLEKMSAEKISELLAK---INHEEQSKIQTQFGIDAKIQERDLYI 764
+ ++E +LT + +K ++ E+ K ++ E++ I+ +E +
Sbjct: 904 LARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELT 963
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
E ++ +YK EE I+ + + + E+ + + + +E ++D +
Sbjct: 964 EKMKKAEEEYK---LEKEEEIS---NLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKI 1017
Query: 825 NRLAVLMDHDRVVEKQLLEIEHE-NKELQKKNQILLEENQNLQISLSDMQQHYNALVEK- 882
+R R EK+ +++ E N+E +K NQ++++ Q L+DMQ LVE+
Sbjct: 1018 DRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKH----QKELNDMQAQ---LVEEC 1070
Query: 883 ANRTDLAESESTKYQTQLRDLESNL 907
A+R +L ++K ++ + L + L
Sbjct: 1071 AHRNELQMQLASK-ESDIEQLRAKL 1094
Score = 56.4 bits (130), Expect = 8e-07
Identities = 90/478 (18%), Positives = 186/478 (38%), Gaps = 23/478 (4%)
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
++Q ++E Q+ + K+ EL E + LE+ +++ ++ Q +IN+ + K
Sbjct: 442 EMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRK 501
Query: 1203 LEQLNTENDNLLSTVAELRSSISSA--VDQRGFEIAELWKQHLAQREA--DFQKTEHELR 1258
EQ N + N+ + V+ L+ + V Q E Q Q E D +TE +
Sbjct: 502 AEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTA 561
Query: 1259 VQLSAFESKYEQLLDSVQSSTQE--ETNKIV------TMEQVTSLQNKLQDKEEHLRNLQ 1310
V+L ++ + + ++S +E E N+I+ T + LQ L+ + +
Sbjct: 562 VRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDS 621
Query: 1311 EKYADVINQIEILRSEIED-----EKV-AFXXXXXXXXXXXXXXXXDLRTE-NQSYKQMQ 1363
E D+ +I L+ E++ EKV +L + N K +Q
Sbjct: 622 EMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQ 681
Query: 1364 EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEY 1423
++ +NE + + + + E K+ E E ++ + Q +
Sbjct: 682 QRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQC 741
Query: 1424 T---ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKES 1480
+ + L Q + E++ E +++LT + E E L +E
Sbjct: 742 SMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLK 801
Query: 1481 EIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
+E+ ++ +E+N + L ++A+L K + E+Q LE ++ ++
Sbjct: 802 GLEK-QMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQV 860
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQ 1598
L+ + + + K + + K+ QLD K + + R L+ + L Q
Sbjct: 861 KELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQ 918
Score = 52.0 bits (119), Expect = 2e-05
Identities = 122/660 (18%), Positives = 257/660 (38%), Gaps = 46/660 (6%)
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q+ + ++ K + +K + + ++ +L E N NL V ++ K + L+ +
Sbjct: 438 QLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKM-LLQHRIN 496
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQ-KDEEIIALNQKINNAQVSYMSMVSDYESKLAQF 1053
+ Q ++ E+ N N+++ L Q +D + ++ N ++ N ++S + + +L +
Sbjct: 497 EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQL------QKQLEEA 550
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
L + R+ K + + +L+ L RE ++ + L+ +K + + + + ++
Sbjct: 551 NDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAIL 610
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ-ERSVLQE-----QSAKLNTE 1167
+ + D D ++ E ++ ER Q+ + K N E
Sbjct: 611 EAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLE 670
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNT---ENDNLLSTVAELRSSI 1224
+ Y + L E+ H V ++ +S E + E + L E R
Sbjct: 671 IDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKA 730
Query: 1225 SSAVDQRGFEIAEL---WKQ------HLAQREADFQKTEHELRVQLSAFESKYEQLLDSV 1275
+ V Q + + L KQ HL + + L +QL +K L + +
Sbjct: 731 ENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNEL 790
Query: 1276 QSSTQEETN-KIVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEIEDEK 1331
++ E N K + + + L+ K E L L ++Y Q+ L+ ++E E+
Sbjct: 791 KTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQ 850
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTEN-QSYKQMQ-EQSILNINEENAQLKKSSXXXXXXXX 1389
F + EN + +++Q E+ L + A+ K S
Sbjct: 851 Y-FSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLL 909
Query: 1390 XXXXRVNDAEAKVLELTHQLELKDSE-IYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI 1448
E+K ++ E+ D + + E LT+ + ++L E K+
Sbjct: 910 EEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKA 969
Query: 1449 ED-LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKI----TESVSLNK 1503
E+ EKE E++ L+ +N N T++ ++ + +++ + KI + L K
Sbjct: 970 EEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRK 1029
Query: 1504 QVAE---LNKALEEEVAKTNEM----QTALENQEIEIVTLNDEITNLQNMVRASSSKIQK 1556
+ E L L +E K N+M Q L + + ++V LQ + + S I++
Sbjct: 1030 KEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQ 1089
Score = 40.3 bits (90), Expect = 0.056
Identities = 44/252 (17%), Positives = 94/252 (37%), Gaps = 5/252 (1%)
Query: 94 LANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKE 153
L N LK + + +K ++ K+ T++ G+ ++E
Sbjct: 786 LQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGN----EGQMRE 841
Query: 154 KDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXED 213
+ L Q + +T + +L+E+I EK++ K + E
Sbjct: 842 LQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAES 901
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSK 273
+ ++E + + E K R ++I KD +S LEEAN +L + E+ +
Sbjct: 902 EQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEE 961
Query: 274 LAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN-MTELTKKIELLE 332
L +++++ K + E + + ++ + ++A M KI+ +
Sbjct: 962 LTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKK 1021
Query: 333 HLNCQIRQTNKE 344
+R+ KE
Sbjct: 1022 ANTQDLRKKEKE 1033
Score = 33.1 bits (72), Expect = 8.5
Identities = 20/74 (27%), Positives = 40/74 (54%), Gaps = 5/74 (6%)
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQ----DKEEHLRNLQEKYADVIN 1318
+FE+++E++ D++ + E N ++ + +L L K +++ N +Y D IN
Sbjct: 6 SFETRFEKM-DNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTIN 64
Query: 1319 QIEILRSEIEDEKV 1332
+I LR + ED +V
Sbjct: 65 KIRDLRMKAEDYEV 78
>BC117174-1|AAI17175.1| 1291|Homo sapiens KIF15 protein protein.
Length = 1291
Score = 86.2 bits (204), Expect = 9e-16
Identities = 161/785 (20%), Positives = 352/785 (44%), Gaps = 80/785 (10%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKLK+ Q+ Q+ E++ + + + K + + +++ + + K + + + ++ T+
Sbjct: 485 EKLKA---QLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATK 541
Query: 563 ELHHLSQKVAELEE-EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
Q+V++L + L++ + ++ V K EM + + S+L++
Sbjct: 542 ACKR--QEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDN 599
Query: 622 QKFDLVQELHILQQKYDEVEDKLADI----SQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
+ + +Q ++ + ++L + S LQ+ E K++ L++ +D L +
Sbjct: 600 DILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQ 659
Query: 678 LALVIENLKLD----KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL----EKMSA 729
+ + + ++D +E+L + LE ++ K E DL L +++S+
Sbjct: 660 MQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSS 719
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
K+ K N E++ ++ + ++Q +L +EN E L +S+ C + + E
Sbjct: 720 VKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLEN-EKLL---ESKACLQDSYDNLQE 775
Query: 790 DRRYSLERKADQLGSYLQEKQKAYS------EYTIQEDELVNRLAVLMDHDRV-VEKQLL 842
++ +++ + L ++ +E + S E E E N+L++ + D+ K++L
Sbjct: 776 IMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEIL 835
Query: 843 EI-EHENKELQK---KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
++ E +E QK K + + + Q L+ SL ++ ++L EK+ +D +
Sbjct: 836 KVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSL-EKSRDSD--KKVVADLMN 892
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---E 955
Q+++L S++ T TL K+E++D+ ++N+ + + +VL +K E +I +
Sbjct: 893 QIQELRSSVCEKTETIDTL----KQELKDINCKYNSALVDR-EESRVLIKKQEVDILDLK 947
Query: 956 YVTQLEAQLQEYKNNI--ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT--EQYINEI 1011
+L ++ + ++ E+L E+LN + E KH Q+ + T E I E+
Sbjct: 948 ETLRLRILSEDIERDMLCEDLAHATEQLNMLT-EASKKHSGLLQSAQEELTKKEALIQEL 1006
Query: 1012 -NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA--QFTTKL----ENMEEEM 1064
+KLN ++ +++ N K+ + S D +S F T L E E+E+
Sbjct: 1007 QHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEI 1066
Query: 1065 Q--RVSKQLLDS--KQHNEELQILVRE---QDDQIKELKETKLTFEMNIPKTEGMIISST 1117
+ R SK L+ + NE+ ++ E +Q++E++ +L + I K ++
Sbjct: 1067 EDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKN--WLLQGQ 1124
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER---SVLQEQSAKLNTELQEC--- 1171
++ + N D LK E+EE I+ER S + E+ K+ +L+E
Sbjct: 1125 LDDIKRQKENSDQNHPDNQQ----LK-NEQEESIKERLAKSKIVEEMLKMKADLEEVQSA 1179
Query: 1172 -YTKIIQLETLNTELTGHDVVNQ---EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y K ++ + E+ + ++ QL+SKLE++ E + + LR +
Sbjct: 1180 LYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECL 1239
Query: 1228 VDQRG 1232
++ G
Sbjct: 1240 AEENG 1244
Score = 79.8 bits (188), Expect = 7e-14
Identities = 186/931 (19%), Positives = 378/931 (40%), Gaps = 74/931 (7%)
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD--LTDKLEKMSAE---KISELL 736
+E+L L KE+ + K + +ED + +L+ +E+ L ++ +++ +E +I L
Sbjct: 345 LEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLR 404
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDL-YIENIESELSKYKSRICRLEES---IAVMED-- 790
+I H + + + R L +E ++ I +LE++ I+ ME
Sbjct: 405 EQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSD 464
Query: 791 -RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
+ KA + +K ++ + EL N + + K+ LE+E E +
Sbjct: 465 KNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQ 524
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVE-KANRTDLAESESTKYQTQLRDLESNLK 908
LQK N L EN L+ + + +Q + L + A + + + YQ R + L
Sbjct: 525 SLQKANLNL--ENL-LEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPK-LS 580
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+L Q +++ + E + + ++E+ E ++ L+A+L E +
Sbjct: 581 PEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEE 640
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA- 1027
+ L +V++L + ++ + ++ D+T+Q +++LN L KQ E
Sbjct: 641 HKNLKLQQHVDKLEHHSTQMQELF----SSERIDWTKQQEELLSQLNVLEKQLQETQTKN 696
Query: 1028 --LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK-------QLLDSKQHN 1078
L ++++ +V S + S ++++ N E+E ++S+ QL + + N
Sbjct: 697 DFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLEN 756
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
E+L D L+E + FE++ E + D NN+
Sbjct: 757 EKLLESKACLQDSYDNLQEI-MKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKER 815
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
L +Q EE+ +E S+K ++ E + Q ET E Q
Sbjct: 816 NNKLSLQFEED--------KENSSKEILKVLEAVRQEKQKETAKCE-------------Q 854
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE--HE 1256
+K+++L ++LL+T ++ SS+ + D +A+L Q R + +KTE
Sbjct: 855 QMAKVQKLE---ESLLAT-EKVISSLEKSRDSDKKVVADLMNQIQELRSSVCEKTETIDT 910
Query: 1257 LRVQLSAFESKYEQ-LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L+ +L KY L+D +S + ++ ++ +L+ ++ ++ L E A
Sbjct: 911 LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAH 970
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
Q+ +L +E + +L+ + K+ EQ N +
Sbjct: 971 ATEQLNML-TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMR 1029
Query: 1376 QLKK--SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
QL+ S AK+LE T + E++D + + E+ +T + E
Sbjct: 1030 QLEHVMDSAAEDPQSPKTPPHFQTHLAKLLE-TQEQEIEDGRASKTSLEHLVTKLNEDRE 1088
Query: 1434 FENVR-QQLVEYEKRIEDLTYEKES--ELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+N ++ E + +E+L E + E L ++ + ++ + +L E
Sbjct: 1089 VKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNE 1148
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
I E ++ +K V E+ K A E+Q+AL N+E+E + + DE+ Q +
Sbjct: 1149 QEESIKERLAKSKIVEEMLKMK----ADLEEVQSALYNKEMECLRMTDEVERTQTL---E 1201
Query: 1551 SSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
S Q+ S ++ +E+ + E+L
Sbjct: 1202 SKAFQEKEQLRSKLEEMYEERERTSQEMEML 1232
Score = 78.2 bits (184), Expect = 2e-13
Identities = 167/885 (18%), Positives = 355/885 (40%), Gaps = 84/885 (9%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL---QNYIQENMDLTDKLEKMSAEKI 732
K A+V E+ + + QL +K L+ ++ + ++++ + T+ +E +
Sbjct: 267 KNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAML 326
Query: 733 SELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
K E++S I+ ++ +++ +I++ + + + +I RLE+ E R
Sbjct: 327 --FFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK--LHKESRG 382
Query: 793 YSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
L + D+L S L+ + + E I+ V + A + +H E + L + K Q
Sbjct: 383 GFLPEEQDRLLSELRNEIQTLREQ-IEHHPRVAKYA-MENHSLREENRRLRLLEPVKRAQ 440
Query: 853 KKNQILLEENQNLQISLSDMQQ---HYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+ + + + + +S M++ + KA + + + K + QL +++ L
Sbjct: 441 EMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN 500
Query: 910 ITHEHQTLIVQKKKEIEDLEIEF------NTQIESAIRDKKV--------LNEKYEKNIE 955
E++ +K +LE E N +E+ + K LN+ + + ++
Sbjct: 501 SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLK 560
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKM---NLELIDKHVQKQQTQSPDYTEQYINEIN 1012
+T Q + + L+ + + N ++D + + P+ EQ I+
Sbjct: 561 IITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVP-PEMNEQAFEAIS 619
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV-SKQL 1071
+ L+ E++ AL K++ + + KL Q KLE+ +MQ + S +
Sbjct: 620 EE---LRTVQEQMSALQAKLDEEEHKNL--------KLQQHVDKLEHHSTQMQELFSSER 668
Query: 1072 LDSKQHNEEL--QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+D + EEL Q+ V E K+L+ET+ T+ + S + + ++ D
Sbjct: 669 IDWTKQQEELLSQLNVLE-----KQLQETQ---------TKNDFLKSEVHDLRVVLHSAD 714
Query: 1130 XXXXXXXXXXXXLKVQEEEEF--IQERSV---LQEQSAKLNTE--------LQECYTKII 1176
K +E+EF + ER + LQ + +L E LQ+ Y +
Sbjct: 715 KELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQ 774
Query: 1177 QLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
++ + ++ N ++ N+ LKS L L + +L + EI
Sbjct: 775 EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEI 834
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKY--EQLLDSVQSSTQEETNKIVT--MEQ 1291
++ + +++ + K E ++ ES E+++ S++ S ++ K+V M Q
Sbjct: 835 LKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKS-RDSDKKVVADLMNQ 893
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L++ + +K E + L+++ D+ + + E+ +V
Sbjct: 894 IQELRSSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLR 953
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
+ +E+ + M + + + E+ L ++S + EA + EL H+L
Sbjct: 954 ILSEDIE-RDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQ 1012
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
K E+ QK +EY + Q E+V E + + ++ LA L +
Sbjct: 1013 KKEEVEQKKNEYNFKMRQ----LEHVMDSAAE-DPQSPKTPPHFQTHLAKLLETQEQEIE 1067
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL-NKALEEE 1515
+ E KL E+ VK E + + +Q+ E+ N LE +
Sbjct: 1068 DGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQ 1112
Score = 77.0 bits (181), Expect = 5e-13
Identities = 161/923 (17%), Positives = 393/923 (42%), Gaps = 62/923 (6%)
Query: 445 KDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
K T + L L+ ++ ++ +I V + + + K+ ++ + E +D + +L +
Sbjct: 341 KVTQLEDLTLKKEKFIQSNKMI-VKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNE 399
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+++ EQI A +N + N +L+L + K + + E + E+
Sbjct: 400 IQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLE--KAFSEI 457
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
+ + + Q + + +++ + + E+ N + + L ++
Sbjct: 458 SGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQL 517
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
+L EL LQ+ +E+ L + +V S++ +H E + ++ K L
Sbjct: 518 ELESELQSLQKANLNLENLLEATKACKRQEV-SQLNKIHAET-LKIITTPTKAYQLHSRP 575
Query: 685 L-KLDKEQLYGTIKDLENDKEDIMNK--LQNYIQENMD------LTDKLEKMSAEKISEL 735
+ KL E G+ L I++ L + M+ ++++L + E++S L
Sbjct: 576 VPKLSPEM--GSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQ-EQMSAL 632
Query: 736 LAKINHEEQSKIQTQFGIDA----KIQERDLYI-ENIE--SELSKYKSRICRLEESIAVM 788
AK++ EE ++ Q +D Q ++L+ E I+ + + S++ LE+ +
Sbjct: 633 QAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQET 692
Query: 789 EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
+ + L+ + L L K S ++ + +++ E+ + ++ +
Sbjct: 693 QTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQE--KEFNKLSERHM-HVQLQL 749
Query: 849 KELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESNL 907
L+ +N+ LLE LQ S ++Q+ +++ +R + E+ ++ L +L L
Sbjct: 750 DNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELL 809
Query: 908 KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + L +Q +++ E+ E +E+ ++K+ K E+ + V +LE L
Sbjct: 810 EAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLAT 869
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQK------QQTQSPDYTEQYINEIN-KLNALLKQ 1020
+ I +L + + K+ +L+++ +Q+ ++T++ D +Q + +IN K N+ L
Sbjct: 870 EKVISSLEKSRDSDKKVVADLMNQ-IQELRSSVCEKTETIDTLKQELKDINCKYNSALVD 928
Query: 1021 KDEEIIALNQK----INNAQVSYMSMVS-DYE-----SKLAQFTTKLENMEEEMQRVSKQ 1070
++E + + ++ ++ + + ++S D E LA T +L + E ++ S
Sbjct: 929 REESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGL 988
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
L +++ + + L++E ++ + KE ++ + N + + ++ ++D +
Sbjct: 989 LQSAQEELTKKEALIQELQHKLNQKKE-EVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKT 1047
Query: 1131 XXXXXXXXXXXLKVQEEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L+ QE+E + ++ L+ KLN + + +I++++ E+
Sbjct: 1048 PPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENL 1107
Query: 1189 DVVNQEQINQ---LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ +Q+ I + L+ +L+ + + +N + + Q E E K+ LA+
Sbjct: 1108 RLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQ--------QLKNEQEESIKERLAK 1159
Query: 1246 REA--DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE 1303
+ + K + +L SA +K + L + +T + ++ L++KL++
Sbjct: 1160 SKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMY 1219
Query: 1304 EHLRNLQEKYADVINQIEILRSE 1326
E ++ + Q+E L E
Sbjct: 1220 EERERTSQEMEMLRKQVECLAEE 1242
Score = 67.3 bits (157), Expect = 4e-10
Identities = 194/1069 (18%), Positives = 439/1069 (41%), Gaps = 75/1069 (7%)
Query: 535 LKLKQMQKTIDNFSKVS-DSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
L Q K I N + V+ D+ + +L E+ L +++AEL + + L D +
Sbjct: 257 LNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTR-DKKKT 315
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
+ +++ + +E K SL+E K +++L + ++K+ + +K+ I + + D
Sbjct: 316 NYMEYFQEAMLFFKKSEQEKK--SLIE--KVTQLEDLTLKKEKFIQ-SNKM--IVKFRED 368
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIEN-LKLDKEQLYGTIKDLENDKEDIMNKLQN 712
Q+ ++ +H E + L + L + N ++ +EQ+ + + E+ + +N
Sbjct: 369 QII-RLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREEN 427
Query: 713 YIQENMDLTDKLEKMSAEKISEL---LAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
++ + ++M A+ I++L ++I+ E+S + Q G K Q+ N E
Sbjct: 428 RRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSD-KNQQGFSPKAQKEPCLFANTEK 486
Query: 770 ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRL 827
++ L S E+ + ++ +L S LQ QKA E ++ + R
Sbjct: 487 LKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQ 546
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY----NALVEKA 883
V +++ + L I K Q ++ + + + + S Q+ N ++ +
Sbjct: 547 EV-SQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEP 605
Query: 884 NRTDLAESESTKYQTQLRDLESNLKRIT-----HEHQTLIVQKKKEIEDLEIEFNTQIES 938
++ E +LR ++ + + EH+ L +Q+ ++ LE +TQ++
Sbjct: 606 VPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQ--HVDKLE-HHSTQMQE 662
Query: 939 AIRDKKV-LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ 997
+++ ++ E+ + + LE QLQE + + L V +L ++ L DK + +
Sbjct: 663 LFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDL-RVVLHSADKELSSVK 721
Query: 998 TQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKL 1057
+ + E NKL+ E + + +++N ++ ++ +
Sbjct: 722 LEYSSFKTNQEKEFNKLS-------ERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQ 774
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISST 1117
E M+ E+ ++S+ L + K+ NE L+ + + ++ KE + + +
Sbjct: 775 EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEI 834
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
++ + +A + KVQ+ EE S+L + + E K +
Sbjct: 835 LKVL--EAVRQEKQKETAKCEQQMAKVQKLEE-----SLLATEKVISSLEKSRDSDKKVV 887
Query: 1178 LETLNT--ELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ +N EL E I+ LK +L+ +N + ++ L E R I + ++
Sbjct: 888 ADLMNQIQELRSSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQ-EVDILDL 946
Query: 1236 AELWKQHLAQREADFQKTEHELR---VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
E + + + + +L QL+ ++ +QS+ +E T K +++
Sbjct: 947 KETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQE- 1005
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQIE-ILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
LQ+KL K+E + + +Y + Q+E ++ S ED + +
Sbjct: 1006 --LQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQE 1063
Query: 1352 LRTEN-QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE 1410
E+ ++ K E + +NE+ ++K + + +++E L+
Sbjct: 1064 QEIEDGRASKTSLEHLVTKLNEDR-EVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQ 1122
Query: 1411 LKDSEIYQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIEDLTYEKESELAILRLKMHEN 1469
+ +I ++ + +D+ QQL E E+ I++ +S++ LKM +
Sbjct: 1123 GQLDDIKRQK--------ENSDQNHPDNQQLKNEQEESIKERL--AKSKIVEEMLKMKAD 1172
Query: 1470 ANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALE---EEVAKTNEMQTAL 1526
++ E+E +++ +E+ T ++ +L LE EE +T++ L
Sbjct: 1173 LEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEML 1232
Query: 1527 ENQEIEIVTLNDEITNLQNMVRASSSKI---QKHVSFASDTKQGRDEQL 1572
Q + N ++ QN+ + + +++V A +T++ R E +
Sbjct: 1233 RKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENV 1281
Score = 49.6 bits (113), Expect = 9e-05
Identities = 119/660 (18%), Positives = 270/660 (40%), Gaps = 52/660 (7%)
Query: 219 TKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQEL 278
T+MQE F + +W +++ LL + + ++ + N L++ ++ + +EL
Sbjct: 658 TQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKEL 717
Query: 279 EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQI 338
K + E + +E L++ N+ +K LLE C
Sbjct: 718 SSVKLEYSSF--------KTNQEKEFNKLSERHMHVQLQLDNLRLENEK--LLESKACLQ 767
Query: 339 RQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSE-TLNQD 397
+ E + S+ + + K+ L KS N ++ + +++ +L +
Sbjct: 768 DSYDNLQEIMKFEIDQLSRNLQNFKKENETL---KSDLNNLMELLEAEKERNNKLSLQFE 824
Query: 398 TDKKINKNEIAK-LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
DK+ + EI K LE V Q K+ E +++ + +I+ LE
Sbjct: 825 EDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLAT----EKVIS--SLEK 878
Query: 457 QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
+ + + + +++ + + L E+KD+N K + E ++
Sbjct: 879 SRDSDKKVVADLMNQIQELRSSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKK 938
Query: 517 DEIDAAN-KNMIKVK-----SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL-HHLSQ 569
E+D + K ++++ + + + + + +++++K+ L + L++
Sbjct: 939 QEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTK 998
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K A ++E + L + + + ++ KM ++E++ ++ + ++
Sbjct: 999 KEALIQELQHKLNQKKEEVEQKK---NEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHL 1055
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
+L+ + E+ED A S+ + + +++ + + L KE +ENL+L+
Sbjct: 1056 AKLLETQEQEIEDGRA--SKTSLEHLVTKLNEDREVKNAEIL--RMKEQLREMENLRLES 1111
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+QL L+ +DI + +N Q + D +L+ E I E LAK ++
Sbjct: 1112 QQLIEKNWLLQGQLDDIKRQKENSDQNHPD-NQQLKNEQEESIKERLAK-----SKIVEE 1165
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
+ A ++E + N E E + + E +E + + ++ +QL S L+E
Sbjct: 1166 MLKMKADLEEVQSALYNKEMECLRMTDEV----ERTQTLESKAF---QEKEQLRSKLEEM 1218
Query: 810 QKAYSEYTIQEDELVNRLAVLM--DHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQ 866
+ E T QE E++ + + ++ ++V Q L + + L+K+N L EE + L+
Sbjct: 1219 YEE-RERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLR 1277
>U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein.
Length = 1312
Score = 85.8 bits (203), Expect = 1e-15
Identities = 191/907 (21%), Positives = 380/907 (41%), Gaps = 83/907 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E + ++ + Q Q +E E+K +K EK +QIT ++ ++K ++K N
Sbjct: 190 ETLRQVRQTQGQKVKEYQMELK--YLKQYKEKACEIRDQITSKEAQL-TSSKEIVKSYEN 246
Query: 533 HKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL------QLHL 585
LK K I+ N SK+ + EI L + + +ELEE+ + QL+
Sbjct: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 306
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ ++ R + + +K+++ E K LL +K +L+ E LQ + D ++ +
Sbjct: 307 LYHNHQRTVR-EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 365
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG---TIKDLEND 702
L I+S+ + ++D + KL +E+ G T L ND
Sbjct: 366 ARDSL--------IQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMND 417
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS---KIQTQFGIDAKIQE 759
+ Q I E D L ++ E SE+L+K +E ++ ++Q G +I E
Sbjct: 418 FAEKETLKQKQIDEIRDKKTGLGRI-IELKSEILSKKQNELKNVKYELQQLEGSSDRILE 476
Query: 760 RDLYIENIESELSKYK--SRICRLEESIAVMEDRRYSLERKADQLGSYLQE--------- 808
D + E ELSK + S + L+ + +++ + L+R +L +++
Sbjct: 477 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 536
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVV-------EKQLLEIEH-ENKELQKKNQILLE 860
+ + ++ +DE + ++ + +KQL + H ++KE+ + L +
Sbjct: 537 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 596
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTLIV 919
N+ L S + N L K L+ E + +D ES+L R+ E +
Sbjct: 597 LNKELASSEQNKNHINNEL--KRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK--S 652
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN-LNMNV 978
K++ + +Q + + D+ N+ + V Q EA+LQE +++++ L +
Sbjct: 653 SKQRAMLAGATAVYSQFITQLTDE---NQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP 709
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYI-----NEINKLNALLKQKDEEIIALNQKIN 1033
++L EL K ++ + Q I EI +L L+ + +I L I
Sbjct: 710 DKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 769
Query: 1034 NAQVSYMSMVSDYESKLAQFT--TKLENMEEEMQRVSKQLLD--SKQHNEELQILVREQD 1089
+ +++ + ES T T +E + E++ V +++ +K +L V +Q
Sbjct: 770 EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTV-QQV 828
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+Q K+ K+ KL T I + + D + K+Q
Sbjct: 829 NQEKQEKQHKL-------DTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-KLQISTN 880
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q R L+EQ+ +L+TE+Q Y +I + + L Q++ +L +K N
Sbjct: 881 -LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 939
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ L+ + E +I + I + + Q+E + K + QLS E E
Sbjct: 940 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNK----VIAQLSECEKHKE 995
Query: 1270 QLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQE---KYADVINQIEILRS 1325
++ + ++ Q+ +T KI E+ L+ + E L+ ++E ++ + Q+++L+
Sbjct: 996 KINEDMRLMRQDIDTQKI--QERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQM 1053
Query: 1326 EIEDEKV 1332
+ E +K+
Sbjct: 1054 KSEHQKL 1060
Score = 72.9 bits (171), Expect = 9e-12
Identities = 189/1085 (17%), Positives = 438/1085 (40%), Gaps = 93/1085 (8%)
Query: 61 LENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE------- 113
L + ++ E AT + + + ++ +K+ ++ ++ +KQYKE
Sbjct: 166 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 225
Query: 114 --LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETT 171
SK + T + +L ++ H + I + DN + L + K ME
Sbjct: 226 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 285
Query: 172 ILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAE 231
+L+EK+ +++ + ++ D +++ K+ + + E
Sbjct: 286 NSELEEKM---EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQE 342
Query: 232 WKD---EKQRLLKDIESKDVRISSLEEANKLLEAARFEIS-LEHSKLAQ-ELEQXXXXXX 286
+ E+ RL + I + + + L A + E+ E ++ +++
Sbjct: 343 KSELLVEQGRLQLQADRHQEHIRARDSLIQSL-ATQLELDGFERGPFSERQIKNFHKLVR 401
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM-TELTKKIELLEHLNCQIRQTNKEL 345
A Q + E++T +++K EI + T L + IEL + + + K +
Sbjct: 402 ERQEGEAKTANQLMNDFAEKET-LKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 460
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
+ +L + S + ++ LI + + A K S L E ++ +K
Sbjct: 461 KYELQQLEGSSDRILELDQE---LIKAERELSKAEK-NSNVETLKMEVISLQNEKADLDR 516
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
+ KL+ ++ LN + T KD I +++ H + SL
Sbjct: 517 TLRKLDQEMEQLNHHTTTR--------TQMEMLTKDKADKDEQIRKIKSRHSDELT--SL 566
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+ N ++QL+ L+ + K++N +++ +LN E+ ++ +N
Sbjct: 567 LGYFPN----------KKQLEDWLHSKSKEIN---------QTRDRLAKLNKELASSEQN 607
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKV---SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
+ + K K +Q+ D V D ++ RL EE+ S++ A L
Sbjct: 608 KNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYS 667
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ V +++ + E AE + + IS L+S+ +L + + + E
Sbjct: 668 QFITQLTDENQSCCPVCQRVFQTE--AELQ-EVISDLQSKLRLAPDKLKSTESELKKKEK 724
Query: 643 KLADISQL-QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ ++ L Q ++K + E + L +++ + +++ ++E L GTI E
Sbjct: 725 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEE 783
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAE----KISELLAKINHEEQSKIQTQFGID 754
+ + ++ + E D+ K+ + +A+ + + ++N E+Q K +
Sbjct: 784 SAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVS 843
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEE---SIAVMEDRRYSLERKADQLGSYLQEKQK 811
+KI+ I++ + ++ KS L+ I+ RR LE + +L + E Q
Sbjct: 844 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELST---EVQS 900
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH-ENKELQKKNQILLEENQNLQISLS 870
Y E E V+ L ++ + +++L+ ++ NK Q K + E+ +N+ +
Sbjct: 901 LYREIK-DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK 959
Query: 871 DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ--KKKEIEDL 928
D++ + K + E+E K QL + E + ++I +E L+ Q ++I++
Sbjct: 960 DIENYIQD--GKDDYKKQKETELNKVIAQLSECEKHKEKI-NEDMRLMRQDIDTQKIQER 1016
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
++ N + + K + E+ +++++ + Q+ Q+ + K+ + L N++ + + +
Sbjct: 1017 WLQDNLTLRKRNEELKEVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLA 1074
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ + QK + + ++ + E +A K ++ I+ ++ N + Y
Sbjct: 1075 LGR--QKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDI------YYK 1126
Query: 1049 KLAQFTTKLENME-EEMQRVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNI 1106
L Q K +M+ EE+ ++ + L S ++++ I +R D+ + + + +
Sbjct: 1127 TLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRV 1186
Query: 1107 PKTEG 1111
+G
Sbjct: 1187 VMLKG 1191
Score = 62.9 bits (146), Expect = 9e-09
Identities = 178/995 (17%), Positives = 411/995 (41%), Gaps = 89/995 (8%)
Query: 598 VYKKMIEMENLAETRLKAISL---LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
V + +E++ L + + KA + + S++ L I++ +E++ + +++ +
Sbjct: 203 VKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNL 262
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY-GTIKDLENDKEDIMNKLQNY 713
K + L+ +I AL + KK++ L+ E+++ GT + L + + ++
Sbjct: 263 S----KIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREK 318
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHE---EQSKIQTQFGIDAK-IQERDLYIENIES 769
++ +D +LEK++ E S LL + E EQ ++Q Q + I+ RD I+++ +
Sbjct: 319 ERKLVDCHRELEKLNKE--SRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLAT 376
Query: 770 ELS-------KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK----QKAYSEYTI 818
+L + R +++ ++ +R+ + A+QL + EK QK E
Sbjct: 377 QLELDGFERGPFSER--QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRD 434
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
++ L + + + + +L +++E ++L+ + +LE +Q L + ++ +
Sbjct: 435 KKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSK---- 490
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
EK + + + E Q + DL+ L+++ E + L ++E T+ +
Sbjct: 491 -AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL---NHHTTTRTQMEMLTK-DK 545
Query: 939 AIRDKKVLNEKYEKNIEYVTQL-----EAQLQEYKNN-IENLNMNVEELNKMNLELIDKH 992
A +D+++ K + E + L + QL+++ ++ + +N + L K+N EL
Sbjct: 546 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSE 605
Query: 993 VQKQQTQSP--DYTEQYINEINKLNALLKQKDEE--IIALNQKINNAQVSYMSMVSDYES 1048
K + EQ + +KL + +D E + L ++I + +M++ +
Sbjct: 606 QNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS-KQRAMLAGATA 664
Query: 1049 KLAQFTTKLENMEEEM----QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+QF T+L + + QRV + + ++ +LQ +R D++K + E
Sbjct: 665 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 724
Query: 1105 NIPKTEGMII--SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ-EEEEFIQERSVLQEQS 1161
+ G++ S I+ + + LK EE+E + + +E+S
Sbjct: 725 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 784
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
AK+ C T + +E EL DV + +I Q +KL+ ++ D + V + +
Sbjct: 785 AKV------CLTDVTIMERFQMELK--DV--ERKIAQQAAKLQGIDL--DRTVQQVNQEK 832
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+D +I EL ++ + ++ Q L+ + +S+ Q+ ++Q Q
Sbjct: 833 QEKQHKLDTVSSKI-ELNRKLIQDQQEQIQ----HLKSTTNELKSEKLQISTNLQRRQQL 887
Query: 1282 ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXX 1341
E + +V SL +++D +E ++ +E + + EK
Sbjct: 888 EEQTVELSTEVQSLYREIKDAKEQ-----------VSPLETTLEKFQQEKEELINKKNTS 936
Query: 1342 XXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK 1401
D++ + ++ + I + KK + K
Sbjct: 937 NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEK 996
Query: 1402 VLELTHQL--ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
+ E + ++ +I ++ + +TL +RN+E + V + E ++ ++++ + ++
Sbjct: 997 INEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEE---ERKQHLKEMGQMQVLQM 1053
Query: 1460 AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
K+ EN ++ + + R K EE + + + Q + + E +
Sbjct: 1054 KSEHQKLEENIDNIK-RNHNLALGRQKGYEEEIIHFKKELR-EPQFRDAEEKYREMMIVM 1111
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ ++ +I TL+ I +M +KI
Sbjct: 1112 RTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
>BC131805-1|AAI31806.1| 913|Homo sapiens CCDC46 protein protein.
Length = 913
Score = 85.8 bits (203), Expect = 1e-15
Identities = 134/699 (19%), Positives = 299/699 (42%), Gaps = 77/699 (11%)
Query: 665 EEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL 724
EE++ ++ ++E + E+L + +++ E+ + KL+ +Q + +
Sbjct: 228 EEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVI 287
Query: 725 EKMSAEKISEL-------LAKINHEEQSKIQTQFGI--DAKIQERDLYIENIESELSKYK 775
+ ++I+EL +N++ + K+ K + + ENI+ L
Sbjct: 288 RETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTN 347
Query: 776 SRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDR 835
R+ ++E S +L + +Q+ +Q +L+ A L +
Sbjct: 348 VRLNKMESEYMAQTQ---STNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQ 404
Query: 836 VVEKQLLEIEHENKELQK-KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
+ +L E++ L K K+ ++ + QN+++ +Q Y+A + + + +
Sbjct: 405 ITCSELQEVKARRNTLHKEKDHLVNDYEQNMKL----LQTKYDADINLLKQEHALSA--S 458
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
K + + +LE N+ ++ + Q +Q+K+++ D E +F Q+E K L YE
Sbjct: 459 KASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKF--QME-----KSHLKHIYE--- 508
Query: 955 EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQSPDYT-EQYINEI 1011
E L+++L + K + + EE K E + + VQ+ Q Q D E++ ++
Sbjct: 509 EKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQV 568
Query: 1012 ----NKLNALLKQKDEEIIA-LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
K+ A +K++ E++ A L + + + + E ++ ++ ++ E ++
Sbjct: 569 ELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQ 628
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQI----KELKETKLTFEMNI---PKTEGMIIS---S 1116
LL +QHN E LVR+ + +I K+L+ + E I K + +I+ +
Sbjct: 629 EKTHLL--QQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEA 686
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+ + ++ NV+ L+ +E++ +E ++ KL E ++ ++
Sbjct: 687 QVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVN---KLKAESEKMKIELK 743
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS----TVAELRSSISSAVDQRG 1232
+ TE+T + + SKL+Q+ E L+ +AEL+++ISS ++
Sbjct: 744 KTHAAETEMT---------LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS 794
Query: 1233 FEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQV 1292
+Q LA E Q + + +Q + +Q + +N++ E+
Sbjct: 795 -------QQQLA-AERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK- 845
Query: 1293 TSLQNKLQDKEEHLRNLQEKYADVINQI--EILRSEIED 1329
LQ+K + +E + ++++Y + + LR E+ED
Sbjct: 846 -KLQHKELESQEQITYIRQEYETKLKGLMPASLRQELED 883
Score = 81.4 bits (192), Expect = 2e-14
Identities = 123/666 (18%), Positives = 322/666 (48%), Gaps = 63/666 (9%)
Query: 479 AKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLK 538
A VQ+ L+++ N+EI+++ K EE I +L ++ ++ ++ + ++
Sbjct: 239 ADVQKILERK-NNEIEELKTL-YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIA 296
Query: 539 QMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDV 598
+++K + ++ +++ E ++LH+ VAE+E+EK +LQ + + +++V
Sbjct: 297 ELKKICEQSTESLNNDWE-----KKLHNA---VAEMEQEKFDLQKQHTENIQELLEDTNV 348
Query: 599 YKKMIEMENLAETR-----LKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQL--- 650
+E E +A+T+ +K + Q + ++ +QK + + +L Q+
Sbjct: 349 RLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCS 408
Query: 651 QSDQVCSEIKSVHLE--------EQIDALSASK--KELALVIENLKLDKEQLYGTIKDLE 700
+ +V + ++H E EQ L +K ++ L+ + L + I++LE
Sbjct: 409 ELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELE 468
Query: 701 NDKEDIMNKLQ-NYIQENMDLTDKLEKMSAEK--ISELLAKINHEEQSKI-QTQFGIDAK 756
+ + +LQ + +Q L D+ K EK + + + H+ QS++ + + K
Sbjct: 469 QNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEEKAHDLQSELDKGKEDTQKK 528
Query: 757 IQERDLYIENIESELSKYKSRICRL--EESIAVMEDRRYSLERKADQLGSYLQEK-QKAY 813
I + + ++ E +L++ + + RL +++ A +E+ + +E ++++ + ++E+ +K
Sbjct: 529 IHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVE 587
Query: 814 SEYT----IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISL 869
++ T ++E + L L D + E+Q++E++ E++ Q+K +L + N +
Sbjct: 588 ADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHE--QEKTHLLQQHNAEKDSLV 645
Query: 870 SDMQQHYNALVEKANRTDLA-ESESTKYQTQ----LRDLESNLKRITHEHQTLIVQKKKE 924
D ++ L ++ ++ E++ +++ + + D+E+ + ++ E + Q+K++
Sbjct: 646 RDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQ 705
Query: 925 IEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM 984
+ +L + + + A R+ +++ K + E +++ +L+ K + M +E K
Sbjct: 706 LVELGLLREEEKQRATREHEIVVNKLKAESE---KMKIELK--KTHAAETEMTLE---KA 757
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEI-NKLNALLKQKDEEIIALNQKINNAQVSY---- 1039
N +L K ++K+ TQ + Q I E+ +++L ++ ++ +A +++ + + +
Sbjct: 758 NSKL--KQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEK 815
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK-QHNEELQILVREQDDQIKELKET 1098
++ D + + +LEN +++ K+L + + E++ + +E + ++K L
Sbjct: 816 KQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPA 875
Query: 1099 KLTFEM 1104
L E+
Sbjct: 876 SLRQEL 881
Score = 74.1 bits (174), Expect = 4e-12
Identities = 143/711 (20%), Positives = 279/711 (39%), Gaps = 79/711 (11%)
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI 954
K+ ++ + E +TL K+ E E+ + ++++ IRD +V+ E E I
Sbjct: 236 KHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQI 295
Query: 955 EYVTQLEAQLQEYKNNI--ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT-------E 1005
+ ++ Q E NN + L+ V E+ + +L +H + Q D
Sbjct: 296 AELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMES 355
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
+Y+ + N ++K+ + + L + N+ + ++ + + ++E
Sbjct: 356 EYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKA 415
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDA 1125
R L K H LV + + +K L +TK ++N+ K E + +S M ++
Sbjct: 416 R-RNTLHKEKDH------LVNDYEQNMK-LLQTKYDADINLLKQEHALSASKASSMIEEL 467
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE---LQECYTKIIQLETLN 1182
LK Q +E +Q + L++Q K E L+ Y + + L
Sbjct: 468 EQ----------NVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEE--KAHDLQ 515
Query: 1183 TELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH 1242
+EL Q++I++ + L++ E ++ V L++ + A + EL +
Sbjct: 516 SELDKGKEDTQKKIHKFEEALKE-KEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEK 574
Query: 1243 L-AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
+ A+ + +K E +L S E + ++ L ++ Q +IV + KL+
Sbjct: 575 VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL--------KLEH 626
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQ 1361
++E LQ+ A+ + + EIE+ + LR N +
Sbjct: 627 EQEKTHLLQQHNAEKDSLVRDHEREIENLE------------------KQLRAANMEH-- 666
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
E I + +AQ+ VN + +L L++ E + T
Sbjct: 667 --ENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQ--QLVELGLLREEEKQRATR 722
Query: 1422 EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE 1481
E+ I + + E E ++ +L + ++T EK + +LK E + + + K S+
Sbjct: 723 EHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANS----KLKQIEK-EYTQKLAKSSQ 777
Query: 1482 IERVKLIEELNVKITESVSLN--KQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
I I EL I+ N +Q+A + + +E + + + + I L DE
Sbjct: 778 I-----IAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDE 832
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELD 1590
+ N N VR + K+Q H S + Q T K L+ A R EL+
Sbjct: 833 LENRSNQVRCAEKKLQ-HKELESQEQITYIRQEYETKLKGLMPASLRQELE 882
Score = 34.7 bits (76), Expect = 2.8
Identities = 40/167 (23%), Positives = 72/167 (43%), Gaps = 22/167 (13%)
Query: 1396 NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
+D EA++ L++K + K HE + L Q++D + +K +E E
Sbjct: 202 SDIEARLNSWNLGLDMKTKMMEAKFHEEKLKLQQKHD---------ADVQKILERKNNEI 252
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
E + R K HE ++K+ + LI + V I E + Q+AEL K E+
Sbjct: 253 EELKTLYRSKQHETEETIRKLEKKVQ----TLIRDCQV-IRE--TKEDQIAELKKICEQS 305
Query: 1516 VAKTN-----EMQTALENQEIEIVTLNDEIT-NLQNMVRASSSKIQK 1556
N ++ A+ E E L + T N+Q ++ ++ ++ K
Sbjct: 306 TESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNK 352
>AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-1
protein.
Length = 685
Score = 85.8 bits (203), Expect = 1e-15
Identities = 130/650 (20%), Positives = 288/650 (44%), Gaps = 51/650 (7%)
Query: 507 SAEEQITQLNDEIDAANKNMIK-VKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
SA+E ++N +++ +N++K +++ K K+ + ++N K + + + ++ L
Sbjct: 7 SAKEHEAEIN-KLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILL 65
Query: 566 HLSQKVAELEEEK-GNLQLHLVDYDSGRMIESD--VYKKMIEME-NLAETRLKAISLLES 621
+ V ++ EK +L+ L + +S I D Y ++++ + +K E
Sbjct: 66 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHER 125
Query: 622 QKFDL-VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
+ + + EL + +++ V +KL + Q C ++ H E +KE++
Sbjct: 126 EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQ-HNREVQSLKEQHQKEISE 184
Query: 681 VIENLKLDKE--------QLYGTIKDLENDKEDIMNKLQNY--IQENMDLTDKLEKMSAE 730
+ E D E ++ G + EN +++ + NY ++E M++ SA
Sbjct: 185 LNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAG 244
Query: 731 KISELLAKINHEEQSKI-QTQFGIDAKIQERDLYIENI-----ESE-LSKYKSRICRLEE 783
KIS+ + ++ S + + Q + E+D +E + E+E L + + LE
Sbjct: 245 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 304
Query: 784 SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
+I ++++ Q + L+E + + T ++D+ +N+L + K+
Sbjct: 305 TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCER 364
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL 903
E EL KK + ++ N L+ ++++ L E D + + K Q++ L
Sbjct: 365 EERLILELGKKVEQTIQYNSELEQKVNELT---GGLEETLKEKDQNDQKLEKLMVQMKVL 421
Query: 904 ESNLKRITHEHQTLI------VQKKKEIE-DLEIEFNTQIESAIRDKKVLNEKYEKNIEY 956
+ + ++ E ++L VQKKK++ DLE+ F +Q E I + + + EK ++
Sbjct: 422 SEDKEVLSAEVKSLYEETINSVQKKKQLSRDLEV-FLSQKEDVILKEHIT--QLEKKLQL 478
Query: 957 VTQLEAQLQEYKNNIENLNMNVEE-----LNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
+ + + L + N + + V+ L +M E+ + +K + + +I
Sbjct: 479 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 538
Query: 1012 NKLNALLK-QKDEEIIALNQKINNAQVSYM-------SMVSDYESKLAQFTTKLENMEEE 1063
N+ L Q+DE+++ L ++I Q + S++ DYE + +LE ++ E
Sbjct: 539 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 598
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMI 1113
+ + LL+ K NE+ ++ + Q++E+ +T E++ K + I
Sbjct: 599 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFI 648
Score = 81.4 bits (192), Expect = 2e-14
Identities = 139/657 (21%), Positives = 288/657 (43%), Gaps = 76/657 (11%)
Query: 595 ESDVYKKM-IEMENLAETRLKA-----ISLLESQKFDLVQELHILQQKYDEVEDKLADIS 648
E ++ KK E+ENL + A I + Q+ V++ ++ +K +ED L ++
Sbjct: 33 EKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQ--VVNEKVKHLEDTLKELE 90
Query: 649 QLQS---DQVCSEIKSVHLEEQIDALSAS------KKELALVIENLKLDKEQLYGTIKDL 699
S D+V + + ++ L+ ++DA +++L I L L KE+ I+ L
Sbjct: 91 SQHSILKDEV-TYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKL 149
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAK-INHEEQSKIQTQFGIDAKIQ 758
+++ + + ++++ L++ ++ISEL ++ E+ K+ F I ++
Sbjct: 150 KSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQG-LK 208
Query: 759 ERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTI 818
E+ EN++ E + I E +ME + L A G QE + +
Sbjct: 209 EQ---CENLQQEKQE---AILNYESLREIMEILQTELGESA---GKISQEFESMKQQQAS 259
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
EL +L + + + ++ EN++L + +++ E L+ ++ ++Q+
Sbjct: 260 DVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE----LENTIKNLQEKNGV 315
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
+ ++ D T L++LE + +T E I + K E+++ F+ + E
Sbjct: 316 YLLSLSQRD----------TMLKELEGKINSLTEEKDDFINKLKNSHEEMD-NFHKKCER 364
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL----NMNVEELNKMNLELI----D 990
R L +K E+ I+Y ++LE ++ E +E + N ++L K+ +++ D
Sbjct: 365 EERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED 424
Query: 991 KHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKL 1050
K V + +S E+ IN + K L +D E+ L+QK V ++ E KL
Sbjct: 425 KEVLSAEVKS--LYEETINSVQKKKQL--SRDLEVF-LSQK---EDVILKEHITQLEKKL 476
Query: 1051 AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
+ +N+ + ++ Q L K +L ++E ++ E E K +N+ +
Sbjct: 477 QLMVEEQDNLNKLLENEQVQKLFVKT---QLYGFLKEMGSEVSEDSEEKDV--VNVLQAV 531
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQE 1170
G ++ E + A D L++++E + +QE SV+Q + +L + L++
Sbjct: 532 GESLAKINEEKCNLAFQRDEKV---------LELEKEIKCLQEESVVQCE--ELKSLLRD 580
Query: 1171 CYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
+ + L E+ Q + ++K+ E+ EN NLL V E+ + S +
Sbjct: 581 YEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKS 637
Score = 72.1 bits (169), Expect = 2e-11
Identities = 113/566 (19%), Positives = 234/566 (41%), Gaps = 46/566 (8%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
++++E L + +S+ L++ + M + + LE A + K + + E E ++
Sbjct: 79 VKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI------KDEFFHEREDLEFKI 132
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKA 883
L + V+EK E+ NK+ E N ++ S +QH + E
Sbjct: 133 NELLLAKEEQGCVIEKLKSELAGLNKQF-----CYTVEQHNREVQ-SLKEQHQKEISE-L 185
Query: 884 NRTDLAESESTKYQT--QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIR 941
N T L++SE K +++ L+ + + E Q I+ + E +EI ESA +
Sbjct: 186 NETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGK 245
Query: 942 DKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
+ ++ V +L+ +L+ + L V L N +L+ Q++
Sbjct: 246 ISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLS---QQELVPEL 302
Query: 1002 DYTEQYINEINKLNAL-LKQKDEEIIALNQKINNA---QVSYMSMVSDYESKLAQFTTKL 1057
+ T + + E N + L L Q+D + L KIN+ + +++ + + ++ F K
Sbjct: 303 ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKC 362
Query: 1058 ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE-LKET--------KLTFEMNIPK 1108
E E + + K++ + Q+N EL+ V E ++E LKE KL +M +
Sbjct: 363 EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS 422
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+ ++S+ ++ + ++ N Q+E+ ++E E+ +L E
Sbjct: 423 EDKEVLSAEVKSLYEETINSVQKKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 482
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND--NLLSTVAELRSSISS 1226
Q+ K+++ E + + + ++ S++ + + E D N+L V E + I+
Sbjct: 483 QDNLNKLLENEQVQKLFVKTQLYGF--LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINE 540
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI 1286
F QR+ + E E++ + E+L ++ QE+
Sbjct: 541 EKCNLAF-----------QRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 589
Query: 1287 VTMEQVTSLQNKLQDKEEHLRNLQEK 1312
+E++ S + LQ ++N EK
Sbjct: 590 KELEEIQSEKEALQSDLLEMKNANEK 615
Score = 68.5 bits (160), Expect = 2e-10
Identities = 131/637 (20%), Positives = 283/637 (44%), Gaps = 62/637 (9%)
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQER-DLYIENIESELSKYK--SRICRLEES 784
SA++ + K+N +++ ++ + IQ++ + +EN+ S ++IC S
Sbjct: 7 SAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC----S 62
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAY-SEYTIQEDEL--VNRLAVLMDHDRVVEKQL 841
I + E+ +E+ ++ +L++ K S+++I +DE+ +N L + ++ D K
Sbjct: 63 ILLQENT--FVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKD- 119
Query: 842 LEIEHENKELQKK-NQILL--EEN----QNLQISLSDMQQHYNALVEKANRTDLAESEST 894
E HE ++L+ K N++LL EE + L+ L+ + + + VE+ NR E +S
Sbjct: 120 -EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNR----EVQSL 174
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN---TQIESAIRDKKVLNEKYE 951
K Q Q K I+ ++T + +KE L E Q E+ ++K+ YE
Sbjct: 175 KEQHQ--------KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYE 226
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
E + L+ +L E I ++++ ++ + + ++ T+ D + +N +
Sbjct: 227 SLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEK-DALLETVNRL 285
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVS---YMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
N L + E + L I N Q Y+ +S ++ L + K+ ++ EE
Sbjct: 286 QGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI 345
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKEL-KETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
+L +S + + ++ I EL K+ + T + N + ++ + +
Sbjct: 346 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQK--VNELTGGLEETLKE 403
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
D +KV E++ + V +N+ +Q+ LE ++
Sbjct: 404 KDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEETINS-VQKKKQLSRDLEVFLSQK-- 460
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAE-------LRSSISSAVDQRGFEIAELWK 1240
DV+ +E I QL+ KL+ + E DNL + +++ + + + G E++E +
Sbjct: 461 EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE 520
Query: 1241 Q----HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
+ ++ Q + +E + L AF+ + E++L+ + + +V E++ SL
Sbjct: 521 EKDVVNVLQAVGESLAKINEEKCNL-AFQ-RDEKVLELEKEIKCLQEESVVQCEELKSL- 577
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVA 1333
L+D E+ L+++ ++ ++ E L+S++ + K A
Sbjct: 578 --LRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNA 612
Score = 59.3 bits (137), Expect = 1e-07
Identities = 95/449 (21%), Positives = 204/449 (45%), Gaps = 33/449 (7%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E +I++ E +KQ+ + DV+ +L +KL++A + L + ++ K+ S
Sbjct: 241 ESAGKISQEFESMKQQ---QASDVH--ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 295
Query: 533 HKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGR 592
+L + +++ TI N + K V L LSQ+ L+E +G + + D
Sbjct: 296 QEL-VPELENTIKNLQE-----KNGVYLLS----LSQRDTMLKELEGKINSLTEEKDDFI 345
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
+ +++M E + I L + +Q L+QK +E+ L + + +
Sbjct: 346 NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK-EK 404
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
DQ ++ K L Q+ LS K+ L+ +++L + K L D E +++ ++
Sbjct: 405 DQ--NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEETINSVQKKKQLSRDLEVFLSQKED 462
Query: 713 YI-QENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
I +E++ +K ++ E+ L + +E+ K+ + + ++E + +SE
Sbjct: 463 VILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSE-DSEE 521
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+ + + ES+A + + + +L + D+ L+++ K E ++ + E + L
Sbjct: 522 KDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDY 581
Query: 832 DHDRVV-EKQLLEIEHENK-------ELQKKNQILLEENQNLQISLSDMQQ--HYNALVE 881
+ ++V+ K+L EI+ E + E++ N+ ENQNL I + ++ Q + +
Sbjct: 582 EQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN 641
Query: 882 KANRTDLAESESTK---YQTQLRDLESNL 907
+ + + E E+ K Q +LRD + L
Sbjct: 642 EKEKCFIKEHENLKPLLEQKELRDRRAEL 670
Score = 37.5 bits (83), Expect = 0.40
Identities = 101/523 (19%), Positives = 208/523 (39%), Gaps = 52/523 (9%)
Query: 145 THLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXX 204
T LS++ KEK + +Q + E + QE I + + E T
Sbjct: 188 TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS 247
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAAR 264
+ + ++Q+ E KD + ++ ++ ++ S +E LE
Sbjct: 248 QEFESMKQQQASDVHELQQKLRTAFTE-KDALLETVNRLQGENEKLLSQQELVPELENTI 306
Query: 265 FEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQS------IEPSCEEKTEIEEKGSLEI 318
+ ++ L Q L ++ ++ S EE +K E
Sbjct: 307 KNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 366
Query: 319 ANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT 378
+ EL KK+E N ++ Q EL L T + + K ++ K
Sbjct: 367 RLILELGKKVEQTIQYNSELEQKVNELTGGLEE--TLKEKDQNDQKLEKLMVQMKVLSED 424
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXX 438
+ + L ET+N KK ++++ V S +D++ KE++ +
Sbjct: 425 KEVLSAEVKSLYEETINSVQKKK----QLSRDLEVFLSQKEDVILKEHITQLEKKL---- 476
Query: 439 XXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLK---QELNDEI-K 494
QL +E Q ++ L+ E V ++ V+ QL +E+ E+ +
Sbjct: 477 ------------QLMVEEQDNLN--KLLE----NEQVQKLF-VKTQLYGFLKEMGSEVSE 517
Query: 495 DVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVS-DS 553
D KD++ L++ E + ++N+E N+ + L+L++ K + S V +
Sbjct: 518 DSEEKDVVNVLQAVGESLAKINEE----KCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 573
Query: 554 NKEIVR-LTEELHHLSQKVAELEEEKGNLQLHLVDY-DSGRMIESDVYKKMIEMENLAET 611
K ++R +E L +++ E++ EK LQ L++ ++ + +I++E +++T
Sbjct: 574 LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT 633
Query: 612 RLKAISLLESQKFDLVQELH---ILQQKYDEVEDKLADISQLQ 651
K+ E +K + + + +L+QK E+ D+ A++ L+
Sbjct: 634 CSKSEIHNEKEKCFIKEHENLKPLLEQK--ELRDRRAELILLK 674
>AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein
protein.
Length = 1173
Score = 85.8 bits (203), Expect = 1e-15
Identities = 191/907 (21%), Positives = 380/907 (41%), Gaps = 83/907 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E + ++ + Q Q +E E+K +K EK +QIT ++ ++K ++K N
Sbjct: 51 ETLRQVRQTQGQKVKEYQMELK--YLKQYKEKACEIRDQITSKEAQL-TSSKEIVKSYEN 107
Query: 533 HKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL------QLHL 585
LK K I+ N SK+ + EI L + + +ELEE+ + QL+
Sbjct: 108 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 167
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ ++ R + + +K+++ E K LL +K +L+ E LQ + D ++ +
Sbjct: 168 LYHNHQRTVR-EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG---TIKDLEND 702
L I+S+ + ++D + KL +E+ G T L ND
Sbjct: 227 ARDSL--------IQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMND 278
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS---KIQTQFGIDAKIQE 759
+ Q I E D L ++ E SE+L+K +E ++ ++Q G +I E
Sbjct: 279 FAEKETLKQKQIDEIRDKKTGLGRI-IELKSEILSKKQNELKNVKYELQQLEGSSDRILE 337
Query: 760 RDLYIENIESELSKYK--SRICRLEESIAVMEDRRYSLERKADQLGSYLQE--------- 808
D + E ELSK + S + L+ + +++ + L+R +L +++
Sbjct: 338 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 397
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVV-------EKQLLEIEH-ENKELQKKNQILLE 860
+ + ++ +DE + ++ + +KQL + H ++KE+ + L +
Sbjct: 398 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 457
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTLIV 919
N+ L S + N L K L+ E + +D ES+L R+ E +
Sbjct: 458 LNKELASSEQNKNHINNEL--KRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK--S 513
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN-LNMNV 978
K++ + +Q + + D+ N+ + V Q EA+LQE +++++ L +
Sbjct: 514 SKQRAMLAGATAVYSQFITQLTDE---NQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP 570
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYI-----NEINKLNALLKQKDEEIIALNQKIN 1033
++L EL K ++ + Q I EI +L L+ + +I L I
Sbjct: 571 DKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 630
Query: 1034 NAQVSYMSMVSDYESKLAQFT--TKLENMEEEMQRVSKQLLD--SKQHNEELQILVREQD 1089
+ +++ + ES T T +E + E++ V +++ +K +L V +Q
Sbjct: 631 EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTV-QQV 689
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+Q K+ K+ KL T I + + D + K+Q
Sbjct: 690 NQEKQEKQHKL-------DTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-KLQISTN 741
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q R L+EQ+ +L+TE+Q Y +I + + L Q++ +L +K N
Sbjct: 742 -LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 800
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ L+ + E +I + I + + Q+E + K + QLS E E
Sbjct: 801 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNK----VIAQLSECEKHKE 856
Query: 1270 QLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQE---KYADVINQIEILRS 1325
++ + ++ Q+ +T KI E+ L+ + E L+ ++E ++ + Q+++L+
Sbjct: 857 KINEDMRLMRQDIDTQKI--QERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQM 914
Query: 1326 EIEDEKV 1332
+ E +K+
Sbjct: 915 KSEHQKL 921
Score = 72.9 bits (171), Expect = 9e-12
Identities = 189/1085 (17%), Positives = 438/1085 (40%), Gaps = 93/1085 (8%)
Query: 61 LENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE------- 113
L + ++ E AT + + + ++ +K+ ++ ++ +KQYKE
Sbjct: 27 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 86
Query: 114 --LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETT 171
SK + T + +L ++ H + I + DN + L + K ME
Sbjct: 87 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 146
Query: 172 ILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAE 231
+L+EK+ +++ + ++ D +++ K+ + + E
Sbjct: 147 NSELEEKM---EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQE 203
Query: 232 WKD---EKQRLLKDIESKDVRISSLEEANKLLEAARFEIS-LEHSKLAQ-ELEQXXXXXX 286
+ E+ RL + I + + + L A + E+ E ++ +++
Sbjct: 204 KSELLVEQGRLQLQADRHQEHIRARDSLIQSL-ATQLELDGFERGPFSERQIKNFHKLVR 262
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM-TELTKKIELLEHLNCQIRQTNKEL 345
A Q + E++T +++K EI + T L + IEL + + + K +
Sbjct: 263 ERQEGEAKTANQLMNDFAEKET-LKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 321
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
+ +L + S + ++ LI + + A K S L E ++ +K
Sbjct: 322 KYELQQLEGSSDRILELDQE---LIKAERELSKAEK-NSNVETLKMEVISLQNEKADLDR 377
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
+ KL+ ++ LN + T KD I +++ H + SL
Sbjct: 378 TLRKLDQEMEQLNHHTTTR--------TQMEMLTKDKADKDEQIRKIKSRHSDELT--SL 427
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+ N ++QL+ L+ + K++N +++ +LN E+ ++ +N
Sbjct: 428 LGYFPN----------KKQLEDWLHSKSKEIN---------QTRDRLAKLNKELASSEQN 468
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKV---SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
+ + K K +Q+ D V D ++ RL EE+ S++ A L
Sbjct: 469 KNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYS 528
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ V +++ + E AE + + IS L+S+ +L + + + E
Sbjct: 529 QFITQLTDENQSCCPVCQRVFQTE--AELQ-EVISDLQSKLRLAPDKLKSTESELKKKEK 585
Query: 643 KLADISQL-QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ ++ L Q ++K + E + L +++ + +++ ++E L GTI E
Sbjct: 586 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEE 644
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAE----KISELLAKINHEEQSKIQTQFGID 754
+ + ++ + E D+ K+ + +A+ + + ++N E+Q K +
Sbjct: 645 SAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVS 704
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEE---SIAVMEDRRYSLERKADQLGSYLQEKQK 811
+KI+ I++ + ++ KS L+ I+ RR LE + +L + E Q
Sbjct: 705 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELST---EVQS 761
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH-ENKELQKKNQILLEENQNLQISLS 870
Y E E V+ L ++ + +++L+ ++ NK Q K + E+ +N+ +
Sbjct: 762 LYREIK-DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK 820
Query: 871 DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ--KKKEIEDL 928
D++ + K + E+E K QL + E + ++I +E L+ Q ++I++
Sbjct: 821 DIENYIQD--GKDDYKKQKETELNKVIAQLSECEKHKEKI-NEDMRLMRQDIDTQKIQER 877
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
++ N + + K + E+ +++++ + Q+ Q+ + K+ + L N++ + + +
Sbjct: 878 WLQDNLTLRKRNEELKEVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLA 935
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ + QK + + ++ + E +A K ++ I+ ++ N + Y
Sbjct: 936 LGR--QKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDI------YYK 987
Query: 1049 KLAQFTTKLENME-EEMQRVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNI 1106
L Q K +M+ EE+ ++ + L S ++++ I +R D+ + + + +
Sbjct: 988 TLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRV 1047
Query: 1107 PKTEG 1111
+G
Sbjct: 1048 VMLKG 1052
Score = 62.9 bits (146), Expect = 9e-09
Identities = 178/995 (17%), Positives = 411/995 (41%), Gaps = 89/995 (8%)
Query: 598 VYKKMIEMENLAETRLKAISL---LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
V + +E++ L + + KA + + S++ L I++ +E++ + +++ +
Sbjct: 64 VKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNL 123
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY-GTIKDLENDKEDIMNKLQNY 713
K + L+ +I AL + KK++ L+ E+++ GT + L + + ++
Sbjct: 124 S----KIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREK 179
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHE---EQSKIQTQFGIDAK-IQERDLYIENIES 769
++ +D +LEK++ E S LL + E EQ ++Q Q + I+ RD I+++ +
Sbjct: 180 ERKLVDCHRELEKLNKE--SRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLAT 237
Query: 770 ELS-------KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK----QKAYSEYTI 818
+L + R +++ ++ +R+ + A+QL + EK QK E
Sbjct: 238 QLELDGFERGPFSER--QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRD 295
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
++ L + + + + +L +++E ++L+ + +LE +Q L + ++ +
Sbjct: 296 KKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSK---- 351
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
EK + + + E Q + DL+ L+++ E + L ++E T+ +
Sbjct: 352 -AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL---NHHTTTRTQMEMLTK-DK 406
Query: 939 AIRDKKVLNEKYEKNIEYVTQL-----EAQLQEYKNN-IENLNMNVEELNKMNLELIDKH 992
A +D+++ K + E + L + QL+++ ++ + +N + L K+N EL
Sbjct: 407 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSE 466
Query: 993 VQKQQTQSP--DYTEQYINEINKLNALLKQKDEE--IIALNQKINNAQVSYMSMVSDYES 1048
K + EQ + +KL + +D E + L ++I + +M++ +
Sbjct: 467 QNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS-KQRAMLAGATA 525
Query: 1049 KLAQFTTKLENMEEEM----QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+QF T+L + + QRV + + ++ +LQ +R D++K + E
Sbjct: 526 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
Query: 1105 NIPKTEGMII--SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ-EEEEFIQERSVLQEQS 1161
+ G++ S I+ + + LK EE+E + + +E+S
Sbjct: 586 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 645
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
AK+ C T + +E EL DV + +I Q +KL+ ++ D + V + +
Sbjct: 646 AKV------CLTDVTIMERFQMELK--DV--ERKIAQQAAKLQGIDL--DRTVQQVNQEK 693
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+D +I EL ++ + ++ Q L+ + +S+ Q+ ++Q Q
Sbjct: 694 QEKQHKLDTVSSKI-ELNRKLIQDQQEQIQ----HLKSTTNELKSEKLQISTNLQRRQQL 748
Query: 1282 ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXX 1341
E + +V SL +++D +E ++ +E + + EK
Sbjct: 749 EEQTVELSTEVQSLYREIKDAKEQ-----------VSPLETTLEKFQQEKEELINKKNTS 797
Query: 1342 XXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK 1401
D++ + ++ + I + KK + K
Sbjct: 798 NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEK 857
Query: 1402 VLELTHQL--ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
+ E + ++ +I ++ + +TL +RN+E + V + E ++ ++++ + ++
Sbjct: 858 INEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEE---ERKQHLKEMGQMQVLQM 914
Query: 1460 AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
K+ EN ++ + + R K EE + + + Q + + E +
Sbjct: 915 KSEHQKLEENIDNIK-RNHNLALGRQKGYEEEIIHFKKELR-EPQFRDAEEKYREMMIVM 972
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ ++ +I TL+ I +M +KI
Sbjct: 973 RTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
>AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein.
Length = 1312
Score = 85.8 bits (203), Expect = 1e-15
Identities = 191/907 (21%), Positives = 380/907 (41%), Gaps = 83/907 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSN 532
E + ++ + Q Q +E E+K +K EK +QIT ++ ++K ++K N
Sbjct: 190 ETLRQVRQTQGQKVKEYQMELK--YLKQYKEKACEIRDQITSKEAQL-TSSKEIVKSYEN 246
Query: 533 HKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL------QLHL 585
LK K I+ N SK+ + EI L + + +ELEE+ + QL+
Sbjct: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 306
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLA 645
+ ++ R + + +K+++ E K LL +K +L+ E LQ + D ++ +
Sbjct: 307 LYHNHQRTVR-EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 365
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG---TIKDLEND 702
L I+S+ + ++D + KL +E+ G T L ND
Sbjct: 366 ARDSL--------IQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMND 417
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS---KIQTQFGIDAKIQE 759
+ Q I E D L ++ E SE+L+K +E ++ ++Q G +I E
Sbjct: 418 FAEKETLKQKQIDEIRDKKTGLGRI-IELKSEILSKKQNELKNVKYELQQLEGSSDRILE 476
Query: 760 RDLYIENIESELSKYK--SRICRLEESIAVMEDRRYSLERKADQLGSYLQE--------- 808
D + E ELSK + S + L+ + +++ + L+R +L +++
Sbjct: 477 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 536
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVV-------EKQLLEIEH-ENKELQKKNQILLE 860
+ + ++ +DE + ++ + +KQL + H ++KE+ + L +
Sbjct: 537 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 596
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT-QLRDLESNLKRITHEHQTLIV 919
N+ L S + N L K L+ E + +D ES+L R+ E +
Sbjct: 597 LNKELASSEQNKNHINNEL--KRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK--S 652
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN-LNMNV 978
K++ + +Q + + D+ N+ + V Q EA+LQE +++++ L +
Sbjct: 653 SKQRAMLAGATAVYSQFITQLTDE---NQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP 709
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYI-----NEINKLNALLKQKDEEIIALNQKIN 1033
++L EL K ++ + Q I EI +L L+ + +I L I
Sbjct: 710 DKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 769
Query: 1034 NAQVSYMSMVSDYESKLAQFT--TKLENMEEEMQRVSKQLLD--SKQHNEELQILVREQD 1089
+ +++ + ES T T +E + E++ V +++ +K +L V +Q
Sbjct: 770 EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTV-QQV 828
Query: 1090 DQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+Q K+ K+ KL T I + + D + K+Q
Sbjct: 829 NQEKQEKQHKL-------DTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-KLQISTN 880
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+Q R L+EQ+ +L+TE+Q Y +I + + L Q++ +L +K N
Sbjct: 881 -LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 939
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE 1269
+ L+ + E +I + I + + Q+E + K + QLS E E
Sbjct: 940 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNK----VIAQLSECEKHKE 995
Query: 1270 QLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQE---KYADVINQIEILRS 1325
++ + ++ Q+ +T KI E+ L+ + E L+ ++E ++ + Q+++L+
Sbjct: 996 KINEDMRLMRQDIDTQKI--QERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQM 1053
Query: 1326 EIEDEKV 1332
+ E +K+
Sbjct: 1054 KSEHQKL 1060
Score = 72.9 bits (171), Expect = 9e-12
Identities = 189/1085 (17%), Positives = 438/1085 (40%), Gaps = 93/1085 (8%)
Query: 61 LENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKE------- 113
L + ++ E AT + + + ++ +K+ ++ ++ +KQYKE
Sbjct: 166 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 225
Query: 114 --LSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETT 171
SK + T + +L ++ H + I + DN + L + K ME
Sbjct: 226 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 285
Query: 172 ILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAE 231
+L+EK+ +++ + ++ D +++ K+ + + E
Sbjct: 286 NSELEEKM---EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQE 342
Query: 232 WKD---EKQRLLKDIESKDVRISSLEEANKLLEAARFEIS-LEHSKLAQ-ELEQXXXXXX 286
+ E+ RL + I + + + L A + E+ E ++ +++
Sbjct: 343 KSELLVEQGRLQLQADRHQEHIRARDSLIQSL-ATQLELDGFERGPFSERQIKNFHKLVR 401
Query: 287 XXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANM-TELTKKIELLEHLNCQIRQTNKEL 345
A Q + E++T +++K EI + T L + IEL + + + K +
Sbjct: 402 ERQEGEAKTANQLMNDFAEKET-LKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 460
Query: 346 ENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKN 405
+ +L + S + ++ LI + + A K S L E ++ +K
Sbjct: 461 KYELQQLEGSSDRILELDQE---LIKAERELSKAEK-NSNVETLKMEVISLQNEKADLDR 516
Query: 406 EIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
+ KL+ ++ LN + T KD I +++ H + SL
Sbjct: 517 TLRKLDQEMEQLNHHTTTR--------TQMEMLTKDKADKDEQIRKIKSRHSDELT--SL 566
Query: 466 IHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKN 525
+ N ++QL+ L+ + K++N +++ +LN E+ ++ +N
Sbjct: 567 LGYFPN----------KKQLEDWLHSKSKEIN---------QTRDRLAKLNKELASSEQN 607
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKV---SDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
+ + K K +Q+ D V D ++ RL EE+ S++ A L
Sbjct: 608 KNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYS 667
Query: 583 LHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVED 642
+ V +++ + E AE + + IS L+S+ +L + + + E
Sbjct: 668 QFITQLTDENQSCCPVCQRVFQTE--AELQ-EVISDLQSKLRLAPDKLKSTESELKKKEK 724
Query: 643 KLADISQL-QSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEN 701
+ ++ L Q ++K + E + L +++ + +++ ++E L GTI E
Sbjct: 725 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEE 783
Query: 702 DKEDIMNK---LQNYIQENMDLTDKLEKMSAE----KISELLAKINHEEQSKIQTQFGID 754
+ + ++ + E D+ K+ + +A+ + + ++N E+Q K +
Sbjct: 784 SAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVS 843
Query: 755 AKIQERDLYIENIESELSKYKSRICRLEE---SIAVMEDRRYSLERKADQLGSYLQEKQK 811
+KI+ I++ + ++ KS L+ I+ RR LE + +L + E Q
Sbjct: 844 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELST---EVQS 900
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEH-ENKELQKKNQILLEENQNLQISLS 870
Y E E V+ L ++ + +++L+ ++ NK Q K + E+ +N+ +
Sbjct: 901 LYREIK-DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK 959
Query: 871 DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ--KKKEIEDL 928
D++ + K + E+E K QL + E + ++I +E L+ Q ++I++
Sbjct: 960 DIENYIQD--GKDDYKKQKETELNKVIAQLSECEKHKEKI-NEDMRLMRQDIDTQKIQER 1016
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
++ N + + K + E+ +++++ + Q+ Q+ + K+ + L N++ + + +
Sbjct: 1017 WLQDNLTLRKRNEELKEVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLA 1074
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ + QK + + ++ + E +A K ++ I+ ++ N + Y
Sbjct: 1075 LGR--QKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDI------YYK 1126
Query: 1049 KLAQFTTKLENME-EEMQRVSKQLLDSKQHNEELQ-ILVREQDDQIKELKETKLTFEMNI 1106
L Q K +M+ EE+ ++ + L S ++++ I +R D+ + + + +
Sbjct: 1127 TLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRV 1186
Query: 1107 PKTEG 1111
+G
Sbjct: 1187 VMLKG 1191
Score = 62.9 bits (146), Expect = 9e-09
Identities = 178/995 (17%), Positives = 411/995 (41%), Gaps = 89/995 (8%)
Query: 598 VYKKMIEMENLAETRLKAISL---LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
V + +E++ L + + KA + + S++ L I++ +E++ + +++ +
Sbjct: 203 VKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNL 262
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLY-GTIKDLENDKEDIMNKLQNY 713
K + L+ +I AL + KK++ L+ E+++ GT + L + + ++
Sbjct: 263 S----KIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREK 318
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHE---EQSKIQTQFGIDAK-IQERDLYIENIES 769
++ +D +LEK++ E S LL + E EQ ++Q Q + I+ RD I+++ +
Sbjct: 319 ERKLVDCHRELEKLNKE--SRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLAT 376
Query: 770 ELS-------KYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK----QKAYSEYTI 818
+L + R +++ ++ +R+ + A+QL + EK QK E
Sbjct: 377 QLELDGFERGPFSER--QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRD 434
Query: 819 QEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNA 878
++ L + + + + +L +++E ++L+ + +LE +Q L + ++ +
Sbjct: 435 KKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSK---- 490
Query: 879 LVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
EK + + + E Q + DL+ L+++ E + L ++E T+ +
Sbjct: 491 -AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL---NHHTTTRTQMEMLTK-DK 545
Query: 939 AIRDKKVLNEKYEKNIEYVTQL-----EAQLQEYKNN-IENLNMNVEELNKMNLELIDKH 992
A +D+++ K + E + L + QL+++ ++ + +N + L K+N EL
Sbjct: 546 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSE 605
Query: 993 VQKQQTQSP--DYTEQYINEINKLNALLKQKDEE--IIALNQKINNAQVSYMSMVSDYES 1048
K + EQ + +KL + +D E + L ++I + +M++ +
Sbjct: 606 QNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS-KQRAMLAGATA 664
Query: 1049 KLAQFTTKLENMEEEM----QRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+QF T+L + + QRV + + ++ +LQ +R D++K + E
Sbjct: 665 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 724
Query: 1105 NIPKTEGMII--SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ-EEEEFIQERSVLQEQS 1161
+ G++ S I+ + + LK EE+E + + +E+S
Sbjct: 725 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 784
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
AK+ C T + +E EL DV + +I Q +KL+ ++ D + V + +
Sbjct: 785 AKV------CLTDVTIMERFQMELK--DV--ERKIAQQAAKLQGIDL--DRTVQQVNQEK 832
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+D +I EL ++ + ++ Q L+ + +S+ Q+ ++Q Q
Sbjct: 833 QEKQHKLDTVSSKI-ELNRKLIQDQQEQIQ----HLKSTTNELKSEKLQISTNLQRRQQL 887
Query: 1282 ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXX 1341
E + +V SL +++D +E ++ +E + + EK
Sbjct: 888 EEQTVELSTEVQSLYREIKDAKEQ-----------VSPLETTLEKFQQEKEELINKKNTS 936
Query: 1342 XXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK 1401
D++ + ++ + I + KK + K
Sbjct: 937 NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEK 996
Query: 1402 VLELTHQL--ELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
+ E + ++ +I ++ + +TL +RN+E + V + E ++ ++++ + ++
Sbjct: 997 INEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEE---ERKQHLKEMGQMQVLQM 1053
Query: 1460 AILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
K+ EN ++ + + R K EE + + + Q + + E +
Sbjct: 1054 KSEHQKLEENIDNIK-RNHNLALGRQKGYEEEIIHFKKELR-EPQFRDAEEKYREMMIVM 1111
Query: 1520 NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
+ ++ +I TL+ I +M +KI
Sbjct: 1112 RTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
>AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein.
Length = 1337
Score = 85.8 bits (203), Expect = 1e-15
Identities = 136/703 (19%), Positives = 296/703 (42%), Gaps = 48/703 (6%)
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
S+ ++ K++ L E L + Q ELE++ ++ L + + + E +K +E
Sbjct: 389 SRKNEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL-EKTAKELEEEITLRKSVESAL 447
Query: 608 LAETRLKAISLLESQKFDL-----VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSV 662
R KA+ ++ ++ + L+ + ++D+L D+ + + S K
Sbjct: 448 RQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVN 507
Query: 663 HLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTD 722
L+ Q+D +A + + L+ + + I+ LE++ D+ +K N + E L
Sbjct: 508 QLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDK--NCLLETAKL-- 563
Query: 723 KLEK----MSAEKISELLAKINHEE-QSKIQTQF-GIDAKIQERDLYIENIESELSKYKS 776
KLEK + + SE + + E + +Q + G++ ++ + + +E E + +
Sbjct: 564 KLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQE 623
Query: 777 RICRLEESIAVME-DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL-AVLMDHD 834
R LE+ + ME D Y L + Q + + KA ++++ + +
Sbjct: 624 RFTDLEKEKSNMEIDMTYQL-KVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAM 682
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE-- 892
+ +EK+LLE E QK +LLE + + D++Q + E + D+ +
Sbjct: 683 KEMEKKLLE---ERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVR 739
Query: 893 ----STKYQTQLRDLESN-LKRITHEHQTLIVQKKKEIED----LEIEFNTQIESA-IRD 942
+ +TQ R L N LK T + TL + +K+ ++ +E++ N + ++A +R
Sbjct: 740 NLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRK 799
Query: 943 KKVLNEKYEKNIEYVTQLEAQLQE-YKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQ 999
++ + K ++ + E YK + L EE K+ EL K +Q ++
Sbjct: 800 ERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDS 859
Query: 1000 SPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
E + + + +E+ L ++ ++ M++ ++ +L + + +
Sbjct: 860 LAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIAS 919
Query: 1060 MEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLT-------FEMNIPKTEGM 1112
+EE + ++ + + EEL +++ +Q+ LK+ +++ FE + TE
Sbjct: 920 LEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQL-LTERT 978
Query: 1113 IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQ 1169
+ + + +++ N + + + + E ER L +Q K EL
Sbjct: 979 LKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELN 1038
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E +I + + EL I QL+S+L+ L+ D+
Sbjct: 1039 EMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDS 1081
Score = 80.2 bits (189), Expect = 6e-14
Identities = 126/707 (17%), Positives = 294/707 (41%), Gaps = 49/707 (6%)
Query: 765 ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELV 824
++I+S ++ + ++ LEE ++ + LE+K + + L++ K E+E+
Sbjct: 385 DSIQSRKNEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKEL------EEEIT 438
Query: 825 NRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN 884
R +V R +E++ ++H+N E Q+K ++ +NL+ ++ ++ L ++
Sbjct: 439 LRKSV-ESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQ 497
Query: 885 RTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKK 944
+ ++ + + Q QL + + L+ T ++K + +I+ ++DK
Sbjct: 498 NSQISTEKVNQLQRQLDETNALLR--TESDTAARLRKTQAESSKQIQQLESNNRDLQDKN 555
Query: 945 VLNE----KYEKN-IEYVTQLEAQLQEYKNNIENLN------MNVEE-LNKMNLELIDKH 992
L E K EK I + LE++ ++ + E +N +EE L + L
Sbjct: 556 CLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVE 615
Query: 993 VQKQQTQS--PDYTEQYIN-------EINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
++K+Q Q D ++ N ++ + L+Q++ E A ++ + Y S+
Sbjct: 616 LEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIE 675
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFE 1103
+ + KL Q+V LL++++ L +++ +I EL + K
Sbjct: 676 EAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLN 735
Query: 1104 MNIPKTEGMIISSTIEP--MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQS 1161
++ I T + +D LK QE ++ + L++Q+
Sbjct: 736 EDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLK-QENNHLMEMKMNLEKQN 794
Query: 1162 AKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR 1221
A+L E Q+ ++ +L+ + + Q+ +LK + E+ L EL+
Sbjct: 795 AELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQ 854
Query: 1222 SSISSAVDQRGFEIAELWKQHLA-----QREADFQKTEHELRVQLSAFESKYEQLLDSVQ 1276
S Q + + + LA ++ +D +K + +++ ++++Q L
Sbjct: 855 DERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKD 914
Query: 1277 S--STQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF 1334
+ ++ EETN+ +T + V +L N+ ++ L+++QE+ + + ++ EI + I+ +
Sbjct: 915 ATIASLEETNRTLTSD-VANLANEKEELNNKLKDVQEQLSRLKDE-EISAAAIKAQFEKQ 972
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXR 1394
++ + K+ + + +EN +L +
Sbjct: 973 LLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHME-------LKSEREK 1025
Query: 1395 VNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
+ K + ++++ + +E Q E +TL ++ + E +R QL
Sbjct: 1026 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1072
Score = 73.7 bits (173), Expect = 5e-12
Identities = 122/636 (19%), Positives = 252/636 (39%), Gaps = 54/636 (8%)
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN-KLNALLKQKDEEII---- 1026
+++ E+ K L +++H+ + Q+ + EQ +N +L K+ +EEI
Sbjct: 385 DSIQSRKNEIQK-KLYTLEEHLSNEM-QAKEELEQKCKSVNTRLEKTAKELEEEITLRKS 442
Query: 1027 ---ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQI 1083
AL Q + + ++Y+ K K N+E ++ + QL D K+ N+ QI
Sbjct: 443 VESALRQ-LEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI 501
Query: 1084 LVREQDDQIKELKETKL---TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
+ + ++L ET T + S+ + ++NN D
Sbjct: 502 STEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETA 561
Query: 1141 XLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLK 1200
LK+ E+EFI +S L+ + + E +N +L G +E + K
Sbjct: 562 KLKL--EKEFINLQSALESERRD----------RTHGSEIIN-DLQGRICGLEEDLKNGK 608
Query: 1201 SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL--- 1257
L ++ E L +L S+ +++ + +Q L Q EA+ + T+ L
Sbjct: 609 ILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVI-QQSLEQEEAEHKATKARLADK 667
Query: 1258 -RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
++ S E+K E + + + +E T K + + + + L+ Q+K ++
Sbjct: 668 NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL 727
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
+ Q ++L ++ + DL+ + Q ++ S + +EN
Sbjct: 728 LKQKDVLNEDVRN----LTLKIEQETQKRCLTQNDLKMQTQQVNTLK-MSEKQLKQENNH 782
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
L + DA+ ++ EL QLE +E Y T Y + + +E E
Sbjct: 783 LMEMKMNLEKQNAELRKERQDADGQMKELQDQLE---AEQYFSTL-YKTQVRELKEECEE 838
Query: 1437 VRQQLVEYEKRIEDLTYEKESELAILRLKM----HENANHYETMQKESEIERVKLIEELN 1492
+ E +++ ++L E++S A L + + E ++ S++E+ K+++EL
Sbjct: 839 KTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELE 898
Query: 1493 VK---------ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+K +TE + + E N+ L +VA + L N+ ++ + +
Sbjct: 899 IKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE 958
Query: 1544 QNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
+ A ++ +K + K +L MN++
Sbjct: 959 EISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK 994
Score = 72.5 bits (170), Expect = 1e-11
Identities = 151/730 (20%), Positives = 314/730 (43%), Gaps = 75/730 (10%)
Query: 299 SIEPSCEEKTEIEEKGSLEIANMTELTKKIELL-EHLNCQIRQTNKELENKLATMGTESK 357
S PSC E I+ + + E+ KK+ L EHL+ ++ Q +ELE K ++ T +
Sbjct: 376 SDSPSCRETDSIQSRKN-------EIQKKLYTLEEHLSNEM-QAKEELEQKCKSVNTRLE 427
Query: 358 AVSSPSKKGSPL-ISRKSGRNTASKMKSPWSQLSSE---TLNQDTDKKIN-KNEIAKLEM 412
+ ++ L S +S + K+ ++E + + DKK N +N++ L+
Sbjct: 428 KTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD 487
Query: 413 VIQSLNK----DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
++ L K + E V + DT +L Q + +
Sbjct: 488 QLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDT---AARLRKTQAESSKQIQQL 544
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK----SAEEQITQLNDEIDAANK 524
+N D+ + + E K +L E +N++ +E + E I L I +
Sbjct: 545 ESNNRDLQDKNCLLETAKLKLEKEF--INLQSALESERRDRTHGSEIINDLQGRICGLEE 602
Query: 525 NMIKVK---SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
++ K + +L+ +Q+Q+ + K SN EI +T +L + Q + + E E
Sbjct: 603 DLKNGKILLAKVELEKRQLQERFTDLEK-EKSNMEI-DMTYQLKVIQQSLEQEEAEHKAT 660
Query: 582 QLHLVD----YDSGRMIES----DVYKKMIE-------MENLAETRLKAISLLESQKFDL 626
+ L D Y+S +S ++ KK++E +ENL K SLL+
Sbjct: 661 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 720
Query: 627 VQELHILQQKYDEVEDKLADIS---QLQSDQVCSEIKSVHLE-EQIDALSASKKELALVI 682
Q+++ L ++ D + + + +++ + ++ + C + ++ +Q++ L S+K+L
Sbjct: 721 QQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQEN 780
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
+L K L +L +++D +++ +Q+ ++ + ++ EL K E
Sbjct: 781 NHLMEMKMNLEKQNAELRKERQDADGQMKE-LQDQLEAEQYFSTLYKTQVREL--KEECE 837
Query: 743 EQSKI--QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E++K+ + Q ERD +E L+K S +L SIA E++ LE++
Sbjct: 838 EKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE--QLARSIA--EEQYSDLEKEKI 893
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
++E + + ++D + A L + +R + + + +E +EL K L+
Sbjct: 894 MKELEIKEMMARHKQELTEKDATI---ASLEETNRTLTSDVANLANEKEELNNK----LK 946
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAE-SESTKYQTQLRDLESNLKRITHEHQTLIV 919
+ Q L D + A+ + + L E + T+ +L ++ + + + + T +
Sbjct: 947 DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1006
Query: 920 QKKKEIEDLEIEFNTQIE----SAIRDKKVLNE---KYEKNIEYVTQLEAQLQEYKNNIE 972
+K+KE L +E ++ E I+ +K LNE + + + +L+ L ++IE
Sbjct: 1007 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1066
Query: 973 NLNMNVEELN 982
L ++ L+
Sbjct: 1067 QLRSQLQALH 1076
Score = 48.4 bits (110), Expect = 2e-04
Identities = 107/523 (20%), Positives = 215/523 (41%), Gaps = 44/523 (8%)
Query: 220 KMQENFI----AMEAEWKDEKQ--RLLKDIESKDVRISSLEEANKLLEAARFEISLEHSK 273
K+++ FI A+E+E +D ++ D++ RI LEE K + ++ LE +
Sbjct: 564 KLEKEFINLQSALESERRDRTHGSEIINDLQG---RICGLEEDLKNGKILLAKVELEKRQ 620
Query: 274 LAQ---ELEQXXXXXXXXXXXXXXLAKQSIEPSCEE----KTEIEEKG----SLEIAN-- 320
L + +LE+ + +QS+E E K + +K S+E A
Sbjct: 621 LQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSE 680
Query: 321 -MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT- 378
M E+ KK+ L ++ E E + + + + K +K + L+ +K N
Sbjct: 681 AMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLK---QSQQKINELLKQKDVLNED 737
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL---NKDLVDKEYVISEKDTXX 435
+ Q + + D K+ ++ L+M + L N L++ + + +++
Sbjct: 738 VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAEL 797
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDE 492
G+ + Q QLE +Q+ V E+ E K+ ++L KQEL DE
Sbjct: 798 RKERQDADGQMKEL-QDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDE 856
Query: 493 IKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+ + I K+ EQ+ + + ++ K K +L++K+M + ++++
Sbjct: 857 RDSLAAQLEITLTKADSEQLAR--SIAEEQYSDLEKEKIMKELEIKEMMAR--HKQELTE 912
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS--GRMIESDVYKKMIEMENLAE 610
+ I L E L+ VA L EK L L D R+ + ++ I+ + E
Sbjct: 913 KDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQ--FE 970
Query: 611 TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH--LEEQI 668
+L L++Q + + E+ ++ D + ++ ++ E+KS L +Q+
Sbjct: 971 KQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQM 1030
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
E+ I + +L T+ ++D E + ++LQ
Sbjct: 1031 IKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQ 1073
Score = 35.5 bits (78), Expect = 1.6
Identities = 53/261 (20%), Positives = 107/261 (40%), Gaps = 15/261 (5%)
Query: 160 VLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMT 219
V ++K + E T L +++ +K Q ++ + + ++Q +
Sbjct: 829 VRELKEECEEKT--KLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYS 886
Query: 220 KMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE 279
+++ I E E K+ R +++ KD I+SLEE N+ L + ++ E +L +L+
Sbjct: 887 DLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLK 946
Query: 280 QXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN-MTELTKKIELLEHLN-CQ 337
A +I+ E++ E + N + E+ + E ++ N
Sbjct: 947 DVQEQLSRLKDEEISAA--AIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTD 1004
Query: 338 IRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQD 397
+R+ KE EN+ M +S+ K +I + N + SQ+ E L
Sbjct: 1005 VRR--KEKENRKLHMELKSER----EKLTQQMIKYQKELNEMQAQIAEESQIRIE-LQMT 1057
Query: 398 TDKKINKNEIAKLEMVIQSLN 418
D K ++I +L +Q+L+
Sbjct: 1058 LDSK--DSDIEQLRSQLQALH 1076
Score = 33.1 bits (72), Expect = 8.5
Identities = 71/359 (19%), Positives = 140/359 (38%), Gaps = 32/359 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQ--VKMKIMETTILDLQEKI--NEKDQIIEAKNKATTXXXX 198
DV +L+ I+++ + Q +KM+ + L + EK E + ++E K
Sbjct: 737 DVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAE 796
Query: 199 XXXXXXXXXXXXXE-----DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSL 253
E + +Q + + + + E +EK +L K+++ K +
Sbjct: 797 LRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQ-- 854
Query: 254 EEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSI-EPSCEEKTEIEE 312
+E + L AA+ EI+L + Q + + I E K E+ E
Sbjct: 855 DERDSL--AAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTE 912
Query: 313 K----GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTES-KAVSSPSKKGS 367
K SLE N T LT + L + ++ K+++ +L+ + E A + ++
Sbjct: 913 KDATIASLEETNRT-LTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEK 971
Query: 368 PLISRKSGRNTA-SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS---------- 416
L++ ++ + A +K+ ++ DTD + + E KL M ++S
Sbjct: 972 QLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMI 1031
Query: 417 -LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
K+L + + I+E+ KD+ I QL+ + Q G +G+ D
Sbjct: 1032 KYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGD 1090
>BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 1898
Score = 85.4 bits (202), Expect = 2e-15
Identities = 150/800 (18%), Positives = 345/800 (43%), Gaps = 61/800 (7%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLT 561
EKL++A+E++ + D ++ ++ ++ + + +L++ + ++ K S KE+V +
Sbjct: 508 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 567
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLE 620
E L + + L+ EK + L ++GR+ +E + K E +L ++ K +L E
Sbjct: 568 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 627
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
S D + ++ Q +E Q + + + + LEE +++ L
Sbjct: 628 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 687
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE--KMSAEKISELLAK 738
+ + +E L + L +++ + +L ++ +LE + A++ E L +
Sbjct: 688 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 747
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
E+++ + G+ ++ + E LS+ +R+ RLE+ +E + ++R+
Sbjct: 748 AAREKEALAKEHAGLAVQL----VAAEREGRTLSEEATRL-RLEKE--ALEGSLFEVQRQ 800
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
QL + ++ + + ++ L LA L +++ Q E +KEL Q L
Sbjct: 801 LAQLEARREQLEAEGQALLLAKETLTGELAGL--RQQIIATQ--EKASLDKELMA--QKL 854
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
++ + Q SL + + + +++ R E+ + + + L+S L+R E + L+
Sbjct: 855 VQAEREAQASLREQRAAHEEDLQRLQRE--KEAAWRELEAERAQLQSQLQR---EQEELL 909
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
+ + E E+L E + RD+ +L + EK + ++ E++ + ++
Sbjct: 910 ARLEAEKEELSEEIAALQQE--RDEGLLLAESEKQ-QALSLKESEKTALSEKLMGTRHSL 966
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
++ + +E + Q +Q Q +E+ L A Q++E A Q++ Q
Sbjct: 967 ATIS-LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA---QREEAAAAHAQEVRRLQEQ 1022
Query: 1039 YMSMVSDYESKL---AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ +S L + T+L +E+ + ++LL++++ E Q ++ Q +E
Sbjct: 1023 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ---EGREVQRQEA 1079
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E + + + E + S+ E + + LK+ E++ Q+ +
Sbjct: 1080 GELRRSLGEGAKEREALRRSN--EELRSAVKKAE-------SERISLKLANEDK-EQKLA 1129
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+L+E + E E T + ++E E + ++ +L+ +++ L++EN L
Sbjct: 1130 LLEEARTAVGKEAGELRTGLQEVERSRLEA-------RRELQELRRQMKMLDSENTRLGR 1182
Query: 1216 TVAEL--RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV-------QLSAFES 1266
+AEL R ++ ++ +Q L + EA + EL+V Q F +
Sbjct: 1183 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1242
Query: 1267 KYEQLLDSVQSSTQEETNKI 1286
+ +LL S++ + E ++
Sbjct: 1243 RERRLLGSLEEARGTEKQQL 1262
Score = 81.4 bits (192), Expect = 2e-14
Identities = 145/727 (19%), Positives = 292/727 (40%), Gaps = 69/727 (9%)
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
A LL +K +L L + QQ+ +E+ + + Q + L Q D L
Sbjct: 478 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE----------LRRQRDRLEEE 527
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+++ ++ + E+ + ++ LE + + +L + T + + + AEK +E
Sbjct: 528 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK-AE 586
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR----LEESIAVMED 790
+ + E +++ + + K++ + +++ S+LS + + L +A +E+
Sbjct: 587 VAEALTKAEAGRVELELSM-TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 645
Query: 791 RRYSLE---RKADQLGSYLQEKQKAYSEYTIQEDE----LVNRLAVLMDHDRVVEKQLLE 843
+ +L+ R+A+Q + +E+Q+ E ++++ L L V +E+QL
Sbjct: 646 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 705
Query: 844 IEHENKELQKK----NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+ HE +LQ++ ++ L Q L+ + + Q+ AL A + E Q
Sbjct: 706 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 765
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L E R E T + +K+ +E E Q+ ++ L + + +
Sbjct: 766 LVAAERE-GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET 824
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L +L + I + +E ++ EL+ K VQ ++ EQ L L
Sbjct: 825 LTGELAGLRQQI----IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 880
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++K+ A +++ + S + + +L L +E E + +S+++ +Q
Sbjct: 881 REKE----AAWRELEAERAQLQSQLQREQEEL------LARLEAEKEELSEEIAALQQER 930
Query: 1079 EELQILVREQDDQ---IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD----XX 1131
+E +L + Q +KE ++T L+ ++ + IS +E DA +
Sbjct: 931 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 990
Query: 1132 XXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTG 1187
L+ Q EE QE LQEQ+ L + C + +L T L
Sbjct: 991 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1050
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
D + +E + + + KL + + ELR S+ +R E ++ +
Sbjct: 1051 RDGLRRELL-EAQRKLRESQEGREVQRQEAGELRRSLGEGAKER-----EALRRSNEELR 1104
Query: 1248 ADFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ +K E E R+ L EQ LL+ +++ +E E T LQ + + E
Sbjct: 1105 SAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAG-----ELRTGLQEVERSRLE 1158
Query: 1305 HLRNLQE 1311
R LQE
Sbjct: 1159 ARRELQE 1165
Score = 73.3 bits (172), Expect = 6e-12
Identities = 150/796 (18%), Positives = 317/796 (39%), Gaps = 59/796 (7%)
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++L+ S ++ ++ +Y+ +D L + + SD SE + LEEQ+ L
Sbjct: 402 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSD---SESERRALEEQLQRLRDKT 458
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA--EKIS 733
E+ + + ++L + L +K ++ + LQ Q+ +L + EK+ A E++
Sbjct: 459 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 518
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++ E++ +Q + +++ +E +E + S + + E+++ +R
Sbjct: 519 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 578
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
L+ + ++ L + + E + +L A L D + + + +L +
Sbjct: 579 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 638
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE----------STKYQTQLRD- 902
L EE LQ +Q E+ R + E S + Q ++
Sbjct: 639 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 698
Query: 903 LESNLKRITHEHQTLIVQ----------KKKEIEDLEIEFNTQIES---AIRDKKVLNEK 949
LE L + HE L Q +++E+E E Q+E+ A R+K+ L ++
Sbjct: 699 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE 758
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+ + E + + L + E L E VQ+Q Q EQ
Sbjct: 759 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE-----VQRQLAQLEARREQLEA 813
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E L + E+ L Q+I ++ S + +AQ KL E E Q +
Sbjct: 814 EGQALLLAKETLTGELAGLRQQI----IATQEKASLDKELMAQ---KLVQAEREAQASLR 866
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ H E+LQ L RE++ +EL+ + + + + + ++ + +E ++ + +
Sbjct: 867 E--QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL-ARLEAEKEELSE-E 922
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L + E++ Q S+ + + L+ +L T+ L T++ E+
Sbjct: 923 IAALQQERDEGLLLAESEKQ--QALSLKESEKTALSEKLMG--TR-HSLATISLEMERQK 977
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH-LAQREA 1248
Q + Q +S + L +E +L + E ++ + V + + +L KQ REA
Sbjct: 978 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1037
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD---KEEH 1305
+ +T +LR+ A + +LL++ + + + + V ++ L+ L + + E
Sbjct: 1038 EELRT--QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1095
Query: 1306 LRNLQEKYADVINQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
LR E+ + + E R ++ ++K +LRT Q ++
Sbjct: 1096 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1155
Query: 1363 QEQSILNINEENAQLK 1378
+ ++ + E Q+K
Sbjct: 1156 RLEARRELQELRRQMK 1171
Score = 67.3 bits (157), Expect = 4e-10
Identities = 159/744 (21%), Positives = 312/744 (41%), Gaps = 65/744 (8%)
Query: 536 KLKQMQKTI-DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
KL+ + ++ D+ SK+S N+ + + +L+ L VA+LEEEK LQ + +
Sbjct: 607 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRL---VAQLEEEKSALQGRQRQAEQEATV 663
Query: 595 ESDVYKKMIEM---ENLAETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADIS-Q 649
+ +++ E+ + +A L+ ++ + E + L Q+L L+ + +++++LA +S Q
Sbjct: 664 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 723
Query: 650 LQSDQVCSEIKSVHLEEQIDAL--------SASKKELALVIENLKLDKE--QLYGTIKDL 699
L + E + Q++AL + +K+ L ++ + ++E L L
Sbjct: 724 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 783
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE-EQSKIQTQFGIDAKIQ 758
+KE + L ++ L + E++ AE + LLAK E + ++ Q I A +
Sbjct: 784 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ--IIATQE 841
Query: 759 ERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKADQLGSYLQ-EKQKAYSEY 816
+ L E + +L + + L E A E+ L+R+ + L+ E+ + S+
Sbjct: 842 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 901
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
+++EL+ RL EK+ L E + ++ +LL E++ Q +LS +
Sbjct: 902 QREQEELLARLEA--------EKEELSEEIAALQQERDEGLLLAESEKQQ-ALSLKESEK 952
Query: 877 NALVEK--ANRTDLA----ESESTKYQTQLRDLE--SNLKRITHEHQTLIVQKKKEIEDL 928
AL EK R LA E E K Q R + S + +T E + L Q++ E
Sbjct: 953 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE-EAAAA 1011
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ +++ RD L ++ + + +L QL+ ++ + L + E + E
Sbjct: 1012 HAQEVRRLQEQARD---LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE- 1067
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ ++ Q Q + + E K L++ +EE+ + +K + ++S D E
Sbjct: 1068 -SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1126
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
KLA + +E + L + ++ E + ++E Q+K L + +
Sbjct: 1127 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1186
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+G + + L+V +E + +R LQEQ + T
Sbjct: 1187 LQGRLALGE-RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-LQEQEGEFRTRE 1244
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + E G + + L+ KLE E AEL +S+A
Sbjct: 1245 RRLLGSL-------EEARGTEKQQLDHARGLELKLEAARAE-------AAELGLRLSAAE 1290
Query: 1229 DQ-RGFEIAELWKQHLAQREADFQ 1251
+ +G E AEL + + +R A+ Q
Sbjct: 1291 GRAQGLE-AELARVEVQRRAAEAQ 1313
Score = 58.8 bits (136), Expect = 1e-07
Identities = 172/920 (18%), Positives = 351/920 (38%), Gaps = 74/920 (8%)
Query: 731 KISELLAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+++E A+ E+Q+ +Q Q D ++E+DL + ++S+L K E +AV
Sbjct: 228 RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 287
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEKQLLEIE 845
+ +LE+ DQ+ L EK +A +QE + L R + + +L
Sbjct: 288 KRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDS 345
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+L + N +L+ LS + R+ S + +S
Sbjct: 346 ESGVQLSGSERTADASNGSLR-GLSGQR-----TPSPPRRSSPGRGRSPRRGPSPACSDS 399
Query: 906 NLKRITHEHQTLIVQKKKEIEDL--EIEFNTQIESAIRDKKVLNEKYEKNI--EYVTQLE 961
+ + H + + +++ +++D+ E + + +R K++ + + E+ E + +L
Sbjct: 400 STLALIH---SALHKRQLQVQDMRGRYEASQDLLGTLR-KQLSDSESERRALEEQLQRLR 455
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+ E+ V+ L N EL+ + + S +Q E+ + L+
Sbjct: 456 DKTDGAMQAHEDAQREVQRLRSAN-ELLSRE-KSNLAHSLQVAQQQAEELRQEREKLQAA 513
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ----- 1076
EE+ ++ Q + + +L + +LE +E + ++K+L++ ++
Sbjct: 514 QEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRA 573
Query: 1077 --HNEELQILVREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPMSDDANNVDXXX 1132
+ LQ E + + + + ++ E+++ K E + ++ +S A N
Sbjct: 574 TLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLS--ALNESLAQ 631
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVV 1191
+++EE+ +Q R EQ A + E QE ++ ++ E L G V
Sbjct: 632 DKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRV 691
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ----HLAQRE 1247
++ L+ +L L E L +A+L +S + E +Q A RE
Sbjct: 692 AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE 751
Query: 1248 ADFQKTEHE-LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+ EH L VQL A E + L + +T+ K + +Q +L E
Sbjct: 752 KEALAKEHAGLAVQLVAAEREGRTL---SEEATRLRLEKEALEGSLFEVQRQLAQLEARR 808
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL-RTENQSYKQMQEQ 1365
L+ + ++ E L E+ + L + E ++ ++EQ
Sbjct: 809 EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQ 868
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRV-NDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
+ E+ +L++ ++ + + + EL +LE + E+ E
Sbjct: 869 RAAH-EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL----SEEI 923
Query: 1425 ITLTQRNDE----FENVRQQLVEYEKRIEDLTYEK----ESELAILRLKMHENANHYETM 1476
L Q DE E+ +QQ + ++ + EK LA + L+M ++
Sbjct: 924 AALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR 983
Query: 1477 QKE---------SEIE--RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTA 1525
Q++ SE+ R + E E L +Q +L K + + + E++T
Sbjct: 984 QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1043
Query: 1526 LENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ-----GRDEQLDNTMNKEL 1580
L E L E+ Q +R S + A + ++ ++ + N+EL
Sbjct: 1044 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEEL 1103
Query: 1581 LDAVPRAELDLAMYMLHQRD 1600
AV +AE + L D
Sbjct: 1104 RSAVKKAESERISLKLANED 1123
Score = 55.6 bits (128), Expect = 1e-06
Identities = 130/725 (17%), Positives = 297/725 (40%), Gaps = 51/725 (7%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+EK N LQV + E + +EK+ + + +
Sbjct: 484 REKSNLAHSLQVAQQQAEE-LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 542
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL---EAARFEIS 268
E + +Q+ +++ + E + ++ L + +D+ + E + L EA R E+
Sbjct: 543 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 602
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
L +KL E LA+ ++ + EEK +L+ +
Sbjct: 603 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 662
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
E Q R LE ++A G E + + + + R+ S+++ +Q
Sbjct: 663 VAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 719
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQ--SLNKDLVDKEY-------VISEKD--TXXXX 437
LS + ++ + + + E + ++ + K+ + KE+ V +E++ T
Sbjct: 720 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 779
Query: 438 XXXXXXGKDTL----------IAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
K+ L +AQL+ +Q EG +L+ E+A +++Q+
Sbjct: 780 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL--TGELAGLRQQII 837
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQI-TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
E ++ + + +KL AE + L ++ A +++ +++ + ++++
Sbjct: 838 A--TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 895
Query: 546 NF-SKVSDSNKEIV-RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
S++ +E++ RL E LS+++A L++E+ L L + + + + +K
Sbjct: 896 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE-GLLLAESEKQQALSLKESEKTA 954
Query: 604 EMENLAETR--LKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E L TR L ISL +E QK D +Q V +++ L++ + E
Sbjct: 955 LSEKLMGTRHSLATISLEMERQKRDAQSRQ---EQDRSTVNALTSELRDLRAQR--EEAA 1009
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ H +E + L ++L ++ + E+L ++ LE+ ++ + +L Q +
Sbjct: 1010 AAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE-AQRKLRE 1067
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+ + ++ ++ EL + + + + +E ++ ESE K
Sbjct: 1068 SQEGREVQRQEAGELRRSLGEGAKERE----ALRRSNEELRSAVKKAESERISLKLANED 1123
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E+ +A++E+ R ++ ++A +L + LQE +++ E + EL ++ +L + + ++
Sbjct: 1124 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE 1183
Query: 841 LLEIE 845
L E++
Sbjct: 1184 LAELQ 1188
Score = 40.3 bits (90), Expect = 0.056
Identities = 70/378 (18%), Positives = 166/378 (43%), Gaps = 23/378 (6%)
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT----QLNDEIDAANKNMIKVK 530
++++A ++ L Q E++ K I K+K+ E ++ +L + +DA+ +K++
Sbjct: 1480 LDQVATLERSL-QATESELRASQEK--ISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1536
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ ++Q++ +SD + L + + L ++VA+ E + G LQL V+ +
Sbjct: 1537 LQRRSLEGELQRSRLG---LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL-TVERLN 1592
Query: 591 GRM--IESDVYKKMIEMENLAETRLKAISLLES---QKFDLVQELHILQQKYDEVEDKLA 645
G + +E ++ L E ++ + L S + L + L + ++++L
Sbjct: 1593 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1652
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q S+ + +S L EQ+ L +L L + +QL ++ + +
Sbjct: 1653 AARQALSE---ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1709
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD-LYI 764
+N +Q E L ++L + +++L A+ E+S ++ + A + D +
Sbjct: 1710 ALNTVQKLQDERRLLQERLGSLQ-RALAQLEAEKREVERSALRLEKDRVALRRTLDKVER 1768
Query: 765 ENIES--ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E + S + + + RL+ ++ E +R+ QL + + ++++S ++ D
Sbjct: 1769 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1828
Query: 823 LVNRLAVLMDHDRVVEKQ 840
+L + + +R+ Q
Sbjct: 1829 QQQQLELQQEVERLRSAQ 1846
Score = 38.7 bits (86), Expect = 0.17
Identities = 64/350 (18%), Positives = 143/350 (40%), Gaps = 32/350 (9%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ + +L E D L + + L ++ +R + A + L + A+ ++
Sbjct: 1392 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAER--DSATSRARQLQKAVAESEEARR 1449
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ +LS +++ +SV+ S +E T++QV +L+ LQ E LR QEK
Sbjct: 1450 SVDGRLSGVQAELALQEESVRRSERERR---ATLDQVATLERSLQATESELRASQEK--- 1503
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
I++++ +++E +K L + +S + ++S L +++ A
Sbjct: 1504 -ISKMKANETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1558
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAK--VLELT--------HQLELKDSEIYQKTHEYTI 1425
Q + +V D+E K L+LT ++E + + K T
Sbjct: 1559 Q----AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1614
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEI 1482
L Q + + R + + +K + +++ + L R + E ++ ++ +
Sbjct: 1615 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1674
Query: 1483 ERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEI 1531
R + + +L ++ E+ +Q+ E L + E E A N +Q + + +
Sbjct: 1675 LRGE-VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1723
>BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 2017
Score = 85.4 bits (202), Expect = 2e-15
Identities = 150/800 (18%), Positives = 345/800 (43%), Gaps = 61/800 (7%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLT 561
EKL++A+E++ + D ++ ++ ++ + + +L++ + ++ K S KE+V +
Sbjct: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLE 620
E L + + L+ EK + L ++GR+ +E + K E +L ++ K +L E
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
S D + ++ Q +E Q + + + + LEE +++ L
Sbjct: 747 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE--KMSAEKISELLAK 738
+ + +E L + L +++ + +L ++ +LE + A++ E L +
Sbjct: 807 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 866
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
E+++ + G+ ++ + E LS+ +R+ RLE+ +E + ++R+
Sbjct: 867 AAREKEALAKEHAGLAVQL----VAAEREGRTLSEEATRL-RLEKE--ALEGSLFEVQRQ 919
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
QL + ++ + + ++ L LA L +++ Q E +KEL Q L
Sbjct: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGL--RQQIIATQ--EKASLDKELMA--QKL 973
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
++ + Q SL + + + +++ R E+ + + + L+S L+R E + L+
Sbjct: 974 VQAEREAQASLREQRAAHEEDLQRLQRE--KEAAWRELEAERAQLQSQLQR---EQEELL 1028
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
+ + E E+L E + RD+ +L + EK + ++ E++ + ++
Sbjct: 1029 ARLEAEKEELSEEIAALQQE--RDEGLLLAESEKQ-QALSLKESEKTALSEKLMGTRHSL 1085
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
++ + +E + Q +Q Q +E+ L A Q++E A Q++ Q
Sbjct: 1086 ATIS-LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA---QREEAAAAHAQEVRRLQEQ 1141
Query: 1039 YMSMVSDYESKL---AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ +S L + T+L +E+ + ++LL++++ E Q ++ Q +E
Sbjct: 1142 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ---EGREVQRQEA 1198
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E + + + E + S+ E + + LK+ E++ Q+ +
Sbjct: 1199 GELRRSLGEGAKEREALRRSN--EELRSAVKKAE-------SERISLKLANEDK-EQKLA 1248
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+L+E + E E T + ++E E + ++ +L+ +++ L++EN L
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEA-------RRELQELRRQMKMLDSENTRLGR 1301
Query: 1216 TVAEL--RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV-------QLSAFES 1266
+AEL R ++ ++ +Q L + EA + EL+V Q F +
Sbjct: 1302 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1361
Query: 1267 KYEQLLDSVQSSTQEETNKI 1286
+ +LL S++ + E ++
Sbjct: 1362 RERRLLGSLEEARGTEKQQL 1381
Score = 81.4 bits (192), Expect = 2e-14
Identities = 145/727 (19%), Positives = 292/727 (40%), Gaps = 69/727 (9%)
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
A LL +K +L L + QQ+ +E+ + + Q + L Q D L
Sbjct: 597 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE----------LRRQRDRLEEE 646
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+++ ++ + E+ + ++ LE + + +L + T + + + AEK +E
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK-AE 705
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR----LEESIAVMED 790
+ + E +++ + + K++ + +++ S+LS + + L +A +E+
Sbjct: 706 VAEALTKAEAGRVELELSM-TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764
Query: 791 RRYSLE---RKADQLGSYLQEKQKAYSEYTIQEDE----LVNRLAVLMDHDRVVEKQLLE 843
+ +L+ R+A+Q + +E+Q+ E ++++ L L V +E+QL
Sbjct: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 824
Query: 844 IEHENKELQKK----NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+ HE +LQ++ ++ L Q L+ + + Q+ AL A + E Q
Sbjct: 825 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L E R E T + +K+ +E E Q+ ++ L + + +
Sbjct: 885 LVAAERE-GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET 943
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L +L + I + +E ++ EL+ K VQ ++ EQ L L
Sbjct: 944 LTGELAGLRQQI----IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 999
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++K+ A +++ + S + + +L L +E E + +S+++ +Q
Sbjct: 1000 REKE----AAWRELEAERAQLQSQLQREQEEL------LARLEAEKEELSEEIAALQQER 1049
Query: 1079 EELQILVREQDDQ---IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD----XX 1131
+E +L + Q +KE ++T L+ ++ + IS +E DA +
Sbjct: 1050 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 1109
Query: 1132 XXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTG 1187
L+ Q EE QE LQEQ+ L + C + +L T L
Sbjct: 1110 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
D + +E + + + KL + + ELR S+ +R E ++ +
Sbjct: 1170 RDGLRRELL-EAQRKLRESQEGREVQRQEAGELRRSLGEGAKER-----EALRRSNEELR 1223
Query: 1248 ADFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ +K E E R+ L EQ LL+ +++ +E E T LQ + + E
Sbjct: 1224 SAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAG-----ELRTGLQEVERSRLE 1277
Query: 1305 HLRNLQE 1311
R LQE
Sbjct: 1278 ARRELQE 1284
Score = 73.3 bits (172), Expect = 6e-12
Identities = 150/796 (18%), Positives = 317/796 (39%), Gaps = 59/796 (7%)
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++L+ S ++ ++ +Y+ +D L + + SD SE + LEEQ+ L
Sbjct: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSD---SESERRALEEQLQRLRDKT 577
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA--EKIS 733
E+ + + ++L + L +K ++ + LQ Q+ +L + EK+ A E++
Sbjct: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 637
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++ E++ +Q + +++ +E +E + S + + E+++ +R
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 697
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
L+ + ++ L + + E + +L A L D + + + +L +
Sbjct: 698 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 757
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE----------STKYQTQLRD- 902
L EE LQ +Q E+ R + E S + Q ++
Sbjct: 758 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 817
Query: 903 LESNLKRITHEHQTLIVQ----------KKKEIEDLEIEFNTQIES---AIRDKKVLNEK 949
LE L + HE L Q +++E+E E Q+E+ A R+K+ L ++
Sbjct: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE 877
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+ + E + + L + E L E VQ+Q Q EQ
Sbjct: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE-----VQRQLAQLEARREQLEA 932
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E L + E+ L Q+I ++ S + +AQ KL E E Q +
Sbjct: 933 EGQALLLAKETLTGELAGLRQQI----IATQEKASLDKELMAQ---KLVQAEREAQASLR 985
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ H E+LQ L RE++ +EL+ + + + + + ++ + +E ++ + +
Sbjct: 986 E--QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL-ARLEAEKEELSE-E 1041
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L + E++ Q S+ + + L+ +L T+ L T++ E+
Sbjct: 1042 IAALQQERDEGLLLAESEKQ--QALSLKESEKTALSEKLMG--TR-HSLATISLEMERQK 1096
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH-LAQREA 1248
Q + Q +S + L +E +L + E ++ + V + + +L KQ REA
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1156
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD---KEEH 1305
+ +T +LR+ A + +LL++ + + + + V ++ L+ L + + E
Sbjct: 1157 EELRT--QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1214
Query: 1306 LRNLQEKYADVINQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
LR E+ + + E R ++ ++K +LRT Q ++
Sbjct: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
Query: 1363 QEQSILNINEENAQLK 1378
+ ++ + E Q+K
Sbjct: 1275 RLEARRELQELRRQMK 1290
Score = 67.3 bits (157), Expect = 4e-10
Identities = 159/744 (21%), Positives = 312/744 (41%), Gaps = 65/744 (8%)
Query: 536 KLKQMQKTI-DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
KL+ + ++ D+ SK+S N+ + + +L+ L VA+LEEEK LQ + +
Sbjct: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRL---VAQLEEEKSALQGRQRQAEQEATV 782
Query: 595 ESDVYKKMIEM---ENLAETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADIS-Q 649
+ +++ E+ + +A L+ ++ + E + L Q+L L+ + +++++LA +S Q
Sbjct: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
Query: 650 LQSDQVCSEIKSVHLEEQIDAL--------SASKKELALVIENLKLDKE--QLYGTIKDL 699
L + E + Q++AL + +K+ L ++ + ++E L L
Sbjct: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE-EQSKIQTQFGIDAKIQ 758
+KE + L ++ L + E++ AE + LLAK E + ++ Q I A +
Sbjct: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ--IIATQE 960
Query: 759 ERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKADQLGSYLQ-EKQKAYSEY 816
+ L E + +L + + L E A E+ L+R+ + L+ E+ + S+
Sbjct: 961 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
+++EL+ RL EK+ L E + ++ +LL E++ Q +LS +
Sbjct: 1021 QREQEELLARLEA--------EKEELSEEIAALQQERDEGLLLAESEKQQ-ALSLKESEK 1071
Query: 877 NALVEK--ANRTDLA----ESESTKYQTQLRDLE--SNLKRITHEHQTLIVQKKKEIEDL 928
AL EK R LA E E K Q R + S + +T E + L Q++ E
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE-EAAAA 1130
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ +++ RD L ++ + + +L QL+ ++ + L + E + E
Sbjct: 1131 HAQEVRRLQEQARD---LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE- 1186
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ ++ Q Q + + E K L++ +EE+ + +K + ++S D E
Sbjct: 1187 -SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1245
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
KLA + +E + L + ++ E + ++E Q+K L + +
Sbjct: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+G + + L+V +E + +R LQEQ + T
Sbjct: 1306 LQGRLALGE-RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-LQEQEGEFRTRE 1363
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + E G + + L+ KLE E AEL +S+A
Sbjct: 1364 RRLLGSL-------EEARGTEKQQLDHARGLELKLEAARAE-------AAELGLRLSAAE 1409
Query: 1229 DQ-RGFEIAELWKQHLAQREADFQ 1251
+ +G E AEL + + +R A+ Q
Sbjct: 1410 GRAQGLE-AELARVEVQRRAAEAQ 1432
Score = 61.3 bits (142), Expect = 3e-08
Identities = 229/1263 (18%), Positives = 485/1263 (38%), Gaps = 107/1263 (8%)
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
LE VIQ+L ++ +E + +D LI ++ + E P L+
Sbjct: 15 LETVIQTLESSVLCQEKGLGARDLAQDAQITSL---PALIREIVTRNLSQPESPVLLPA- 70
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE------KLKSAEEQITQL----NDEI 519
T + + + + L+QEL+ ++D+ + E K + E++ Q E+
Sbjct: 71 TEMASLLSLQEENQLLQQELS-RVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGEL 129
Query: 520 DAAN-KNMIKVKSNHKLKLKQMQ----KTIDNFSKVSDSNKEIV-RLTEELHHLSQKVAE 573
+ + +++ + +L++ Q + + + + ++V RL ++ ++ +E
Sbjct: 130 ETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSE 189
Query: 574 LE----EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
LE E G L Q L D + + +ES + + +E E L ++ + ++ D
Sbjct: 190 LEQQLLERSGELEQQRLRDTEHSQDLESALIR--LEEEQQRSASLAQVNAMLREQLDQAG 247
Query: 629 ELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD 688
+ Q +++ D ++ + + E EE +A +++ L++ +
Sbjct: 248 SAN--QALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVG 305
Query: 689 KEQLYGTIKDL-ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
+L +K E D + +L + + L + +++E A+ E+Q+ +
Sbjct: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAG--LGLSTGLRLAESRAEAALEKQALL 363
Query: 748 QTQFGI---DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
Q Q D ++E+DL + ++S+L K E +AV + +LE+ DQ+
Sbjct: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNK 421
Query: 805 YLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
L EK +A +QE + L R + + +L +L + N
Sbjct: 422 DLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASN 481
Query: 863 QNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK 922
+L+ LS + R+ S + +S+ + H + + +++
Sbjct: 482 GSLR-GLSGQR-----TPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIH---SALHKRQ 532
Query: 923 KEIEDL--EIEFNTQIESAIRDKKVLNEKYEKNI--EYVTQLEAQLQEYKNNIENLNMNV 978
+++D+ E + + +R K++ + + E+ E + +L + E+ V
Sbjct: 533 LQVQDMRGRYEASQDLLGTLR-KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREV 591
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
+ L N EL+ + + S +Q E+ + L+ EE+ ++ Q
Sbjct: 592 QRLRSAN-ELLSRE-KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ-------HNEELQILVREQDDQ 1091
+ + +L + +LE +E + ++K+L++ ++ + LQ E +
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 1092 IKELKETKLTFEMNIPK--TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+ + + ++ E+++ K E + ++ +S A N +++EE+
Sbjct: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLS--ALNESLAQDKLDLNRLVAQLEEEKS 767
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+Q R EQ A + E QE ++ ++ E L G V ++ L+ +L L
Sbjct: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
Query: 1209 ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ----HLAQREADFQKTEHE-LRVQLSA 1263
E L +A+L +S + E +Q A RE + EH L VQL A
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 1264 FESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEIL 1323
E + L + +T+ K + +Q +L E L+ + ++ E L
Sbjct: 888 AEREGRTL---SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL 944
Query: 1324 RSEIEDEKVAFXXXXXXXXXXXXXXXXDL-RTENQSYKQMQEQSILNINEENAQLKKSSX 1382
E+ + L + E ++ ++EQ + E+ +L++
Sbjct: 945 TGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH-EEDLQRLQREKE 1003
Query: 1383 XXXXXXXXXXXRV-NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE----FENV 1437
++ + + + EL +LE + E+ E L Q DE E+
Sbjct: 1004 AAWRELEAERAQLQSQLQREQEELLARLEAEKEEL----SEEIAALQQERDEGLLLAESE 1059
Query: 1438 RQQLVEYEKRIEDLTYEK----ESELAILRLKMHENANHYETMQKE---------SEIE- 1483
+QQ + ++ + EK LA + L+M ++ Q++ SE+
Sbjct: 1060 KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119
Query: 1484 -RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
R + E E L +Q +L K + + + E++T L E L E+
Sbjct: 1120 LRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQ-----GRDEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
Q +R S + A + ++ ++ + N+EL AV +AE + L
Sbjct: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
Query: 1598 QRD 1600
D
Sbjct: 1240 NED 1242
Score = 55.6 bits (128), Expect = 1e-06
Identities = 130/725 (17%), Positives = 297/725 (40%), Gaps = 51/725 (7%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+EK N LQV + E + +EK+ + + +
Sbjct: 603 REKSNLAHSLQVAQQQAEE-LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL---EAARFEIS 268
E + +Q+ +++ + E + ++ L + +D+ + E + L EA R E+
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
L +KL E LA+ ++ + EEK +L+ +
Sbjct: 722 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
E Q R LE ++A G E + + + + R+ S+++ +Q
Sbjct: 782 VAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQ--SLNKDLVDKEY-------VISEKD--TXXXX 437
LS + ++ + + + E + ++ + K+ + KE+ V +E++ T
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 438 XXXXXXGKDTL----------IAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
K+ L +AQL+ +Q EG +L+ E+A +++Q+
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL--TGELAGLRQQII 956
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQI-TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
E ++ + + +KL AE + L ++ A +++ +++ + ++++
Sbjct: 957 A--TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
Query: 546 NF-SKVSDSNKEIV-RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
S++ +E++ RL E LS+++A L++E+ L L + + + + +K
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE-GLLLAESEKQQALSLKESEKTA 1073
Query: 604 EMENLAETR--LKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E L TR L ISL +E QK D +Q V +++ L++ + E
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQ---EQDRSTVNALTSELRDLRAQR--EEAA 1128
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ H +E + L ++L ++ + E+L ++ LE+ ++ + +L Q +
Sbjct: 1129 AAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE-AQRKLRE 1186
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+ + ++ ++ EL + + + + +E ++ ESE K
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKERE----ALRRSNEELRSAVKKAESERISLKLANED 1242
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E+ +A++E+ R ++ ++A +L + LQE +++ E + EL ++ +L + + ++
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE 1302
Query: 841 LLEIE 845
L E++
Sbjct: 1303 LAELQ 1307
Score = 40.3 bits (90), Expect = 0.056
Identities = 70/378 (18%), Positives = 166/378 (43%), Gaps = 23/378 (6%)
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT----QLNDEIDAANKNMIKVK 530
++++A ++ L Q E++ K I K+K+ E ++ +L + +DA+ +K++
Sbjct: 1599 LDQVATLERSL-QATESELRASQEK--ISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ ++Q++ +SD + L + + L ++VA+ E + G LQL V+ +
Sbjct: 1656 LQRRSLEGELQRSRLG---LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL-TVERLN 1711
Query: 591 GRM--IESDVYKKMIEMENLAETRLKAISLLES---QKFDLVQELHILQQKYDEVEDKLA 645
G + +E ++ L E ++ + L S + L + L + ++++L
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q S+ + +S L EQ+ L +L L + +QL ++ + +
Sbjct: 1772 AARQALSE---ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1828
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD-LYI 764
+N +Q E L ++L + +++L A+ E+S ++ + A + D +
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQ-RALAQLEAEKREVERSALRLEKDRVALRRTLDKVER 1887
Query: 765 ENIES--ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E + S + + + RL+ ++ E +R+ QL + + ++++S ++ D
Sbjct: 1888 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1947
Query: 823 LVNRLAVLMDHDRVVEKQ 840
+L + + +R+ Q
Sbjct: 1948 QQQQLELQQEVERLRSAQ 1965
Score = 38.7 bits (86), Expect = 0.17
Identities = 64/350 (18%), Positives = 143/350 (40%), Gaps = 32/350 (9%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ + +L E D L + + L ++ +R + A + L + A+ ++
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAER--DSATSRARQLQKAVAESEEARR 1568
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ +LS +++ +SV+ S +E T++QV +L+ LQ E LR QEK
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERR---ATLDQVATLERSLQATESELRASQEK--- 1622
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
I++++ +++E +K L + +S + ++S L +++ A
Sbjct: 1623 -ISKMKANETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1677
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAK--VLELT--------HQLELKDSEIYQKTHEYTI 1425
Q + +V D+E K L+LT ++E + + K T
Sbjct: 1678 Q----AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEI 1482
L Q + + R + + +K + +++ + L R + E ++ ++ +
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793
Query: 1483 ERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEI 1531
R + + +L ++ E+ +Q+ E L + E E A N +Q + + +
Sbjct: 1794 LRGE-VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1842
>BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein.
Length = 2002
Score = 85.4 bits (202), Expect = 2e-15
Identities = 139/641 (21%), Positives = 289/641 (45%), Gaps = 60/641 (9%)
Query: 481 VQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
++ QL +E KD ++ L KL+ AE++ +L D + ++ S +L
Sbjct: 1247 IEVQLSEE-QIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTS----ELTDE 1301
Query: 541 QKTIDNFSKVSDSNK-EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVY 599
+ T ++ S++ D+ E +R +E+ L + L+++ +++ +++ R+I +
Sbjct: 1302 RNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVME---ARLIRAAEI 1358
Query: 600 KKMIEMENLA-ETRLK---AISLLESQKFDLVQE----LHILQQKYDEVEDKLADISQLQ 651
++ ++ E RLK A+ ++ K L QE L + QQ ++E +L D LQ
Sbjct: 1359 NGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGD---LQ 1415
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
+D S+ L+++ L+A ++ L +E ++ +L + +++ + Q
Sbjct: 1416 ADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ 1475
Query: 712 NYIQENMDLTDKLEKMSAEKIS--ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIES 769
+ L + + + AE S + L + + + Q ++A++Q+ E+
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1535
Query: 770 ELSKYKSRICRLEESIAVMEDRR----------YSLERKADQLGSYLQEKQKAYSEYTIQ 819
L+K K ++ LE + E+ L++ QL ++KQK E
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQLKQMEVQLEEEYEDKQKVLRE---- 1591
Query: 820 EDELVNRLAVLMD----HDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQH 875
+ EL +LA L D D EK+L + K L Q++L+ +N S ++ Q
Sbjct: 1592 KRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1651
Query: 876 YNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
N L E A + ++ DL + I + +T + ++ ++ + E +
Sbjct: 1652 KNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIA-KAKTALEEQLSRLQREKNEIQNR 1710
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQK 995
+E D++ +NE +K+ V Q L + I +L +EE NK EL +K +Q
Sbjct: 1711 LE---EDQEDMNELMKKHKAAVAQASRDLAQ----INDLQAQLEEANKEKQELQEK-LQA 1762
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
Q+Q ++ EQ + ++K +L+ +++ +I L ++ + + V ES ++
Sbjct: 1763 LQSQ-VEFLEQ--SMVDK--SLVSRQEAKIRELETRLEFER----TQVKRLESLASRLKE 1813
Query: 1056 KLENMEEEM-QRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+E + EE QR++ + + K+ N+ LQ +R+ +++ EL
Sbjct: 1814 NMEKLTEERDQRIAAENRE-KEQNKRLQRQLRDTKEEMGEL 1853
Score = 79.0 bits (186), Expect = 1e-13
Identities = 129/699 (18%), Positives = 287/699 (41%), Gaps = 55/699 (7%)
Query: 768 ESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
E ++ I +L + E R L +D+L S + E SE T E
Sbjct: 1253 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELT---SELT-DERNTGESA 1308
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
+ L+D + + L E E KELQ + L ++ + +++ + + + A + D
Sbjct: 1309 SQLLDAETA---ERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDD 1365
Query: 888 LAESE-STKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVL 946
A E KY+ +R+++ KR+ E + K E+E + Q+E + D +
Sbjct: 1366 DAGGEWRLKYERAVREVDFTKKRLQQEFED-----KLEVEQ---QNKRQLERRLGDLQAD 1417
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ 1006
+E+ ++ ++ QL+ + Q +++ +++E N EL K + S + E
Sbjct: 1418 SEESQRALQ---QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEA 1474
Query: 1007 YINEINKLNALLKQKD---EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
++ + L ++KD E +L Q++ + ++ + K+ +L+++ +
Sbjct: 1475 QREKLQR-EKLQREKDMLLAEAFSLKQQLEEKDMD----IAGFTQKVVSLEAELQDISSQ 1529
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+ L K+ +L+ V++Q++ EL E T +M + + + M + +E +
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEE---ELDEQAGTIQM-LEQLKQMEVQ--LEEEYE 1583
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT 1183
D V L Q + R E +L +L+ + + +
Sbjct: 1584 DKQKVLREKRELEGKLATLSDQ-----VNRRDF--ESEKRLRKDLKRTKALLADAQLMLD 1636
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL 1243
L + ++ +I QLK++LE E++ + + R ++ ++ +I ++ K
Sbjct: 1637 HLK-NSAPSKREIAQLKNQLE----ESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT 1691
Query: 1244 AQRE--ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD 1301
A E + Q+ ++E++ +L + +L+ +++ + + + Q+ LQ +L++
Sbjct: 1692 ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLA---QINDLQAQLEE 1748
Query: 1302 KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN-QSYK 1360
+ + LQEK + +Q+E L + D+ + + + +S
Sbjct: 1749 ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1808
Query: 1361 QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKT 1420
++++ + EE Q + ++ D + ++ EL K++E +K
Sbjct: 1809 SRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR----KEAEASRKK 1864
Query: 1421 HEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESEL 1459
HE + L ++++ L KRI DL E E+
Sbjct: 1865 HELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEM 1903
Score = 78.6 bits (185), Expect = 2e-13
Identities = 133/741 (17%), Positives = 324/741 (43%), Gaps = 59/741 (7%)
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEK 578
I KN+ K K ++ T+ +V S ++I EE+ L K+ + E+E+
Sbjct: 1218 IRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKER 1277
Query: 579 GNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD 638
L+L+ D R+ S++ ++ + N E+ + + +++ +E+ LQ +YD
Sbjct: 1278 NELRLN-SDRLESRI--SELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYD 1334
Query: 639 E-------VEDKLADISQLQSDQVCSEIKS--------VHLEEQIDALSASKKELALVIE 683
+E ++ + +++ ++ E+ + E + + +KK L E
Sbjct: 1335 ALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1394
Query: 684 N-LKLD---KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
+ L+++ K QL + DL+ D E+ LQ ++ LT +L+ + +
Sbjct: 1395 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVR-- 1452
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESE-LSKYKSRICRLEESI-AVMEDRRYSLER 797
NHE + K Q +F + + E ++ E L + K + S+ +E++ +
Sbjct: 1453 NHELEKK-QRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAG 1511
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
++ S E Q S+ + E L L D + V+ Q E++ + +Q
Sbjct: 1512 FTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQ----- 1566
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES--NLKRITHEHQ 915
+LE+ + +++ L + + ++ + + + + Q RD ES L++ +
Sbjct: 1567 MLEQLKQMEVQLEEEYEDKQKVLREKRELE-GKLATLSDQVNRRDFESEKRLRKDLKRTK 1625
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
L+ + ++ L+ ++ E A ++ N+ E ++A+ + + IE+L+
Sbjct: 1626 ALLADAQLMLDHLKNSAPSKREIA----QLKNQLEESEFTCAAAVKAR-KAMEVEIEDLH 1680
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
+ ++++ K L ++ + + Q + + + + +N L+K+ + ++
Sbjct: 1681 LQIDDIAKAKTAL-EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD---- 1735
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
++ ++D +++L + + + ++E++Q + Q+ +Q + + LV Q+ +I+EL
Sbjct: 1736 ----LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD-KSLVSRQEAKIREL 1790
Query: 1096 KETKLTFE-MNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
ET+L FE + + E + + +E ++++ + L+ ++ + +
Sbjct: 1791 -ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQ-RQLRDTKE 1848
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL--EQLNTEN 1210
E L + A+ + + E + LE N L + ++I L++ + E + EN
Sbjct: 1849 EMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDEN 1908
Query: 1211 DNLLSTVAELRSSISSAVDQR 1231
++L+++ + S + S ++ R
Sbjct: 1909 EDLINSEGD--SDVDSELEDR 1927
Score = 75.4 bits (177), Expect = 2e-12
Identities = 127/672 (18%), Positives = 278/672 (41%), Gaps = 50/672 (7%)
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKK---EIEDLEIEFNTQIESAIRDKK 944
L+E + +++ L S L++ E L + + I +L E + + +
Sbjct: 1251 LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQ 1310
Query: 945 VLNEKYEKNI---EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSP 1001
+L+ + + + + + +L+ Q K +E + M V E + I+ V
Sbjct: 1311 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1370
Query: 1002 DYT--EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLEN 1059
E+ + E++ L+Q+ E+ + + Q+ N Q+ + D ++ + L+
Sbjct: 1371 WRLKYERAVREVDFTKKRLQQEFEDKLEVEQQ-NKRQLE--RRLGDLQADSEESQRALQQ 1427
Query: 1060 MEEEMQRVSKQLLDSKQH-------NEELQILVREQDDQI----KELKETKLTFEMNIPK 1108
++++ QR++ +L D+K H N EL+ R D ++ +E + KL E + +
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE-KLQR 1486
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+ M+++ + D L+ + ++ QE S + AK+ +L
Sbjct: 1487 EKDMLLAEAFS-LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQE-SKDEASLAKVKKQL 1544
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELR---SSIS 1225
++ K+ E E G + EQ+ Q++ +LE+ + +L EL +++S
Sbjct: 1545 RDLEAKVKDQEEELDEQAG-TIQMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLS 1603
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE--QLLDSVQSS----- 1278
V++R FE + ++ L + +A + L ++ SK E QL + ++ S
Sbjct: 1604 DQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCA 1663
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+ K + +E + L ++ D + L+E+ + + + +++ +E+++
Sbjct: 1664 AAVKARKAMEVE-IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELM 1722
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN-EENAQLKKSSXXXXXXXXXXXXRVND 1397
DL N Q++E + +E Q +S V+
Sbjct: 1723 KKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSR 1782
Query: 1398 AEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKES 1457
EAK+ EL +LE + +++ ++ L + ++ R Q + E R EKE
Sbjct: 1783 QEAKIRELETRLEFERTQV-KRLESLASRLKENMEKLTEERDQRIAAENR------EKEQ 1835
Query: 1458 ELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVA 1517
+ R E +KE+E R K E++++ E+ + + Q A+L A +
Sbjct: 1836 NKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ-ADLKLAFK---- 1890
Query: 1518 KTNEMQTALENQ 1529
+ ++Q A+E++
Sbjct: 1891 RIGDLQAAIEDE 1902
Score = 54.0 bits (124), Expect = 4e-06
Identities = 101/473 (21%), Positives = 193/473 (40%), Gaps = 34/473 (7%)
Query: 1148 EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE--Q 1205
E+ +ER+ L+ S +L + + E +++ + NT + +++ E +L+++ E +
Sbjct: 1271 EKAEKERNELRLNSDRLESRISELTSELT--DERNTGESASQLLDAETAERLRAEKEMKE 1328
Query: 1206 LNTENDNLLSTVAELRSSISSAVDQRGFEI-AEL--------W--KQHLAQREADFQKT- 1253
L T+ D L + + + A R EI E+ W K A RE DF K
Sbjct: 1329 LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKR 1388
Query: 1254 -EHELRVQLSAFESKYEQL---LDSVQSSTQEETNKIVTMEQVTS-LQNKLQDKEEHLRN 1308
+ E +L + QL L +Q+ ++E + +++ L +LQD + HL
Sbjct: 1389 LQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEG 1448
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
Q + ++ + SE+ L E S KQ E+ +
Sbjct: 1449 QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDM-LLAEAFSLKQQLEEKDM 1507
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
+I Q S + + AKV + LE K + ++ E T+
Sbjct: 1508 DI-AGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI- 1565
Query: 1429 QRNDEFENVRQQLVE-YEKRIEDLTYEKESELAILRLKMHENANHYETMQK-ESEIERVK 1486
Q ++ + + QL E YE + + L ++E E + L N +E+ ++ +++R K
Sbjct: 1566 QMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTK 1625
Query: 1487 -LIEELNVKITE---SVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLN---DE 1539
L+ + + + S +++A+L LEE A + E+EI L+ D+
Sbjct: 1626 ALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD 1685
Query: 1540 ITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
I + + S++Q+ + + + E ++ M K AV +A DLA
Sbjct: 1686 IAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKA-AVAQASRDLA 1737
Score = 37.9 bits (84), Expect = 0.30
Identities = 91/467 (19%), Positives = 187/467 (40%), Gaps = 41/467 (8%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
K Q K+Q + AE KQ+L E KD+ I+ + LEA +IS + SK
Sbjct: 1478 KLQREKLQREKDMLLAEAFSLKQQL----EEKDMDIAGFTQKVVSLEAELQDISSQESKD 1533
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE-IANMTELTKKIELLEH 333
L + L + +E+ E+ G+++ + + ++ ++E
Sbjct: 1534 EASLAK----------VKKQLRDLEAKVKDQEEELDEQAGTIQMLEQLKQMEVQLEEEYE 1583
Query: 334 LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
++ + +ELE KLAT+ + S+K RK + T + + +QL +
Sbjct: 1584 DKQKVLREKRELEGKLATLSDQVNRRDFESEKR----LRKDLKRTKALLAD--AQLMLDH 1637
Query: 394 LNQDTDKKIN----KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLI 449
L K KN++ + E + K E I + + +
Sbjct: 1638 LKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQL 1697
Query: 450 AQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAE 509
++LQ E + + + ED+NE+ K + + + ++ +N DL +L+ A
Sbjct: 1698 SRLQREKNEIQN-----RLEEDQEDMNELMKKHKAAVAQASRDLAQIN--DLQAQLEEAN 1750
Query: 510 EQITQLNDEIDAANKNMIKVKS---NHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH 566
++ +L +++ A + ++ + L +Q K + +++ ++ RL
Sbjct: 1751 KEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASR 1810
Query: 567 LSQKVAELEEEKG-NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFD 625
L + + +L EE+ + + + + ++ + EM LA +A + D
Sbjct: 1811 LKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMD 1870
Query: 626 LVQELHILQQKYDEVEDKLA--DISQLQSDQVCSEIKSVHLEEQIDA 670
L + L Q + + KLA I LQ+ + E++S E+ I++
Sbjct: 1871 L-ESLEAANQSL-QADLKLAFKRIGDLQA-AIEDEMESDENEDLINS 1914
>AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting citron
kinase protein.
Length = 2027
Score = 85.4 bits (202), Expect = 2e-15
Identities = 169/852 (19%), Positives = 356/852 (41%), Gaps = 84/852 (9%)
Query: 756 KIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSE 815
++Q+ +E E+++ R+ +E AV+ + L+ Q Q+ +E
Sbjct: 457 ELQDSQDKCHKMEQEMTRLHRRVSEVE---AVLSQKEVELKASETQRSLLEQDLATYITE 513
Query: 816 YTIQEDELVN-RLAVLMDHDRVVEKQLLEIEHENKELQK-KNQILLEENQNLQISLSDMQ 873
+ + L R+ V + D+ ++ L +I ++++LQ+ K Q + + +++ ++ ++
Sbjct: 514 CSSLKRSLEQARMEVSQEDDKALQL-LHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLE 572
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ LV R+DL ESE + + + + H+ Q K E+ +
Sbjct: 573 ED---LVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEK 629
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
E ++ ++ L EK EK ++ T+ LQ + E +E+L N E + +
Sbjct: 630 INAEQQLKIQE-LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ--NREDSSEGI 686
Query: 994 QKQQTQSPDYTEQYIN---EINKLNALLKQKD----EEIIALNQKINNA---QVSYMSMV 1043
+K+ ++ + E++ L LKQK+ E+I L+ +I + + +M+
Sbjct: 687 RKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMM 746
Query: 1044 SDYESK-------LAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL-------QILVREQD 1089
+E + L++ + M+ +++ + +++++ + N+ Q ++ Q+
Sbjct: 747 QRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 806
Query: 1090 DQIKELKETKLTFEMNIPKTEGMI--ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE 1147
+ I EL++ K E K E + +E +S ++ + ++ E
Sbjct: 807 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHE 866
Query: 1148 EEFIQ-ERSV------LQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQL 1199
E+ ++ +R + LQE+ ++L T LQ + QL TEL +E+I L
Sbjct: 867 EQKLELKRQLTELQLSLQERESQL-TALQAARAALESQLRQAKTELEETTAEAEEEIQAL 925
Query: 1200 KSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL-AQREADFQKTEHELR 1258
+ +++ + D L ++ + + + ++Q + AEL Q+ ++ D ++
Sbjct: 926 TAHRDEIQRKFDALRNSCTVI-TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI 984
Query: 1259 VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
VQL S+ + L + + T++ TME + + L+++ L L ++ +
Sbjct: 985 VQL---RSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKER 1041
Query: 1319 QIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ-- 1376
Q E RS + DEK F +Q + ++ L + E A+
Sbjct: 1042 QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEIL 1101
Query: 1377 -LKKSSXXXXXXXXXXXXRVNDAEAK--VLELT-HQLELK---DSEIYQKTHEYTITLTQ 1429
L+++ ++ND E K +LE+ L+ K + E+ Q+ E L Q
Sbjct: 1102 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 1161
Query: 1430 RNDEFEN----VRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERV 1485
+ D +N + Q L E R DL + S+L + +H + + + ++
Sbjct: 1162 QMDLQKNHIFRLTQGLQEALDRA-DLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQT 1220
Query: 1486 KLIEELNVKITESVSLNK------------------QVAELNKALEEEVAKTNEMQTALE 1527
KLI+ L K+ + K Q EL ALE+E A+ E++ AL+
Sbjct: 1221 KLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQ 1280
Query: 1528 NQEIEIVTLNDE 1539
IE+ + +E
Sbjct: 1281 KTRIELRSAREE 1292
Score = 85.0 bits (201), Expect = 2e-15
Identities = 135/748 (18%), Positives = 314/748 (41%), Gaps = 49/748 (6%)
Query: 549 KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENL 608
+VS + + ++L ++ S+K+ E++E++ Q+ + ++ E V + +L
Sbjct: 527 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSAR--RRSDL 584
Query: 609 AETRLKAISLL-ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQ 667
E+ L+ L E K + H L + D+ + ++ + ++L+ ++K L+E+
Sbjct: 585 YESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 644
Query: 668 IDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKM 727
++ + E +++N++ KE+ ++ L+N +ED ++ + E ++LE
Sbjct: 645 LEKAVKASTEATELLQNIRQAKERAERELEKLQN-REDSSEGIRKKLVE----AEELE-- 697
Query: 728 SAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
EK E H E Q + + KI+ D I+ +L+ +E++
Sbjct: 698 --EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLAD--------KETLEN 744
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
M R E +A + G L E++ + + L R+ L + +++ L +
Sbjct: 745 MMQRH---EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRN 801
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNL 907
K ++ L ++ L+ ++ L E+ + + S K +L +LE+ L
Sbjct: 802 MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS-HQDHSDK--NRLLELETRL 858
Query: 908 KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-TQLEAQLQE 966
+ ++ EH+ ++ K+++ +L++ + ES + + E + T+LE E
Sbjct: 859 REVSLEHEEQKLELKRQLTELQLSLQER-ESQLTALQAARAALESQLRQAKTELEETTAE 917
Query: 967 YKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQSPDYTEQYINEINKLNALLKQKDEE 1024
+ I+ L + +E+ + L + + + Q TE E+N N L ++ +E
Sbjct: 918 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA-ELNNQNFYLSKQLDE 976
Query: 1025 IIALNQKI--NNAQVSYMSM-VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
N +I ++V ++ +++ E +L +E ++ + +Q++D + N+EL
Sbjct: 977 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDEL 1036
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
R+ + L + K FE + + + M ++ D
Sbjct: 1037 LEKERQWEAWRSVLGDEKSQFECRVRELQRM-----LDTEKQSRARADQRITESRQVVEL 1091
Query: 1142 LKVQEEEEFIQERSVLQEQSAK---LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
+ + E + + L+EQ K L+ +L + K LE +N + + ++ Q
Sbjct: 1092 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE-MNARSLQQKLETERELKQ 1150
Query: 1199 -LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL 1257
L + +L + D + + L + A+D+ ++ + + L + + Q
Sbjct: 1151 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA--DLLKTERSDLEYQLENIQVLYSHE 1208
Query: 1258 RVQLSAFESKYEQLLDSVQSSTQEETNK 1285
+V++ S+ +L+D +Q+ + K
Sbjct: 1209 KVKMEGTISQQTKLIDFLQAKMDQPAKK 1236
Score = 81.0 bits (191), Expect = 3e-14
Identities = 140/746 (18%), Positives = 313/746 (41%), Gaps = 54/746 (7%)
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLR 901
L+ + ++KK I +E Q+ Q M+Q L + + + S+ + +L+
Sbjct: 438 LDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQK---EVELK 494
Query: 902 DLESNLKRITHEHQTLIVQ---KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVT 958
E+ + + T I + K+ +E +E + + + A++ + E+ K E
Sbjct: 495 ASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 554
Query: 959 Q-LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
Q +AQ++E + + L ++ + + +L + +++ + + ++ + +KL
Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSARRRS-DLYESELRESRLAAEEFKRKATECQHKLLKA 613
Query: 1018 LKQKDEEI--IALNQKINNAQVSYMSMVSDYESKLAQFTTK----LENMEEEMQRVSKQL 1071
Q E+ A +KIN Q + + + K + +T+ L+N+ + +R ++L
Sbjct: 614 KDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 673
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISST--IEPMSDDANNVD 1129
+ Q+ E+ +R++ + +EL+E +++ E + E +N
Sbjct: 674 -EKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQI 732
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
+ + EEE ++ +L EQ A +N +KI LE EL+
Sbjct: 733 KKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSE-- 786
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
N+ N S Q N + + ++ELR Q G E + L ++
Sbjct: 787 -ANKLAANS--SLFTQRNMKAQEEM--ISELRQQKFYLETQAGK--LEAQNRKLEEQLEK 839
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
+H + +L E++ ++ S + E K+ Q+T LQ LQ++E L L
Sbjct: 840 ISHQDHSDKNRLLELETRLREV------SLEHEEQKLELKRQLTELQLSLQERESQLTAL 893
Query: 1310 QEKYADVINQIEILRSEIED---EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQS 1366
Q A + +Q+ ++E+E+ E LR ++EQ
Sbjct: 894 QAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQ- 952
Query: 1367 ILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI- 1425
+ + E+NA+L + + A ++++L +++ EI ++ + T
Sbjct: 953 LNQLTEDNAELNNQN----FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 1008
Query: 1426 --TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIE 1483
T+ + +Q+++ E + D EKE + R + + + +E +E +
Sbjct: 1009 KQTMEALKTTCTMLEEQVMDLE-ALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ-R 1066
Query: 1484 RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
+ ++ + + ++ ++QV EL A++E A+ +Q AL+ Q+++ +L+D++ +L
Sbjct: 1067 MLDTEKQSRARADQRITESRQVVEL--AVKEHKAEILALQQALKEQKLKAESLSDKLNDL 1124
Query: 1544 QN---MVRASSSKIQKHVSFASDTKQ 1566
+ M+ ++ +Q+ + + KQ
Sbjct: 1125 EKKHAMLEMNARSLQQKLETERELKQ 1150
Score = 81.0 bits (191), Expect = 3e-14
Identities = 142/753 (18%), Positives = 320/753 (42%), Gaps = 69/753 (9%)
Query: 617 SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD-QVCSEIKSVHLEEQIDALSASK 675
S +E + +EL Q K ++E ++ + + S+ + K V L+ S +
Sbjct: 445 SSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE 504
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
++LA I K L ++ + + + L + +++ L + E+ ++ E+
Sbjct: 505 QDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEM 564
Query: 736 LAKINHEEQSKIQTQFGID---AKIQERDLYIENIESELSKYKSRICRLEES-------I 785
+N E+ + + D ++++E L E + + ++ + ++ + ++
Sbjct: 565 RLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEY 624
Query: 786 AVMEDRRYSLERKADQLGSYLQEKQKAYSEYT-----IQE-----DELVNRLAVLMDHDR 835
A +E + K +L L++ KA +E T I++ + + +L D
Sbjct: 625 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSE 684
Query: 836 VVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKAN---RTDLAESE 892
+ K+L+E E EL++K++ Q+L++ L +QHY ++ + + DLA+ E
Sbjct: 685 GIRKKLVEAE----ELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 740
Query: 893 STKYQTQLRDLESNLK-RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY- 950
+ + Q + E++ K +I E + +I +I LE +E + +K N
Sbjct: 741 TLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI---VELSEANKLAANSSLF 797
Query: 951 -EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
++N++ ++ ++L++ K +E +E N+ +++ ++K Q + +
Sbjct: 798 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRK----LEEQLEKISHQDHSDKNRLLE 853
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
+L + + +E+ + L +++ Q+S + + ES+L +E ++++
Sbjct: 854 LETRLREVSLEHEEQKLELKRQLTELQLS----LQERESQLTALQAARAALESQLRQAKT 909
Query: 1070 QLLDSK-QHNEELQILVREQDD---QIKELKE-----TKLTFEMNIPKTEGMIISST--- 1117
+L ++ + EE+Q L +D+ + L+ T L ++N + +++
Sbjct: 910 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 969
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQ 1177
+ D+A+ + L+ + E +Q S Q A L T +++
Sbjct: 970 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA-LKTTCTMLEEQVMD 1028
Query: 1178 LETLNTELTGHD---VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
LE LN EL + + + KS+ E E +L T + R+ DQR E
Sbjct: 1029 LEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRAR----ADQRITE 1084
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTS 1294
++ + + + +A+ + L+ Q ES ++L D + E N S
Sbjct: 1085 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMN-------ARS 1137
Query: 1295 LQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
LQ KL+ + E + L E+ A + Q+++ ++ I
Sbjct: 1138 LQQKLETERELKQRLLEEQAKLQQQMDLQKNHI 1170
Score = 77.4 bits (182), Expect = 4e-13
Identities = 149/906 (16%), Positives = 374/906 (41%), Gaps = 52/906 (5%)
Query: 353 GTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEM 412
G E V K ++ R + + S + + L + + + ++++ K+E
Sbjct: 411 GEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQ 470
Query: 413 VIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNT 472
+ L++ + + E V+S+K+ + +A E + +
Sbjct: 471 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQ 530
Query: 473 EDVNEIAKVQEQLKQELN-DEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKS 531
ED + + + +Q EIK+ + +E+++ + QL +++ +A +
Sbjct: 531 EDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL---MMNQLEEDLVSARRR----SD 583
Query: 532 NHKLKLKQMQKTIDNFS-KVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
++ +L++ + + F K ++ ++++ ++ + A+LE+ QL + +
Sbjct: 584 LYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQEL-- 641
Query: 591 GRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQL 650
+ +K ++ A L+ I + + +++L + + + KL + +L
Sbjct: 642 -----QEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEEL 696
Query: 651 QSDQVCSEIKSVHLEEQIDALSASKKELALVIEN-LK---LDKEQLYGTIKDLE---NDK 703
+ +++ + HLE + +E V++N +K DKE L ++ E ++K
Sbjct: 697 EEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK 756
Query: 704 EDIMNKLQNYIQENMDLTDKLEKMSAE--KISELLAKINHEEQSKIQTQFGIDAKIQERD 761
I+++ + I LE+ E + ++L A + Q ++ Q + ++++++
Sbjct: 757 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 816
Query: 762 LYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQED 821
Y +E++ K +++ +LEE + + + +S + + +L + L+E + E Q+
Sbjct: 817 FY---LETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEE---QKL 870
Query: 822 ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE 881
EL +L L + E QL ++ L+ + L + L+ + ++ ++ AL
Sbjct: 871 ELKRQLTELQLSLQERESQLTALQAARAALESQ---LRQAKTELEETTAEAEEEIQALTA 927
Query: 882 KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK---KKEIEDLEIEFNTQIES 938
+ T + DLE L ++T ++ L Q K++++ + ++
Sbjct: 928 HRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQL 987
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQT 998
+ E E+ ++ +Q + ++ K L V +L +N EL++K Q +
Sbjct: 988 RSEVDHLRREITEREMQLTSQKQT-MEALKTTCTMLEEQVMDLEALNDELLEKERQWEAW 1046
Query: 999 QS--PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK 1056
+S D Q+ + +L +L + + +Q+I ++ V ++++++
Sbjct: 1047 RSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQA 1106
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI---KELK------ETKLTFEMNIP 1107
L+ + + + +S +L D ++ + L++ R ++ +ELK + KL +M++
Sbjct: 1107 LKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ 1166
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAK---L 1164
K ++ ++ D A+ + ++V E ++ + +Q+ L
Sbjct: 1167 KNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFL 1226
Query: 1165 NTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSI 1224
++ + K L + E Q N+LK LE+ L + + R +
Sbjct: 1227 QAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIEL 1286
Query: 1225 SSAVDQ 1230
SA ++
Sbjct: 1287 RSAREE 1292
Score = 69.7 bits (163), Expect = 8e-11
Identities = 170/765 (22%), Positives = 313/765 (40%), Gaps = 65/765 (8%)
Query: 243 IESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEP 302
+ K+V + + E LLE E S L + LEQ L E
Sbjct: 486 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQ 545
Query: 303 SCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTN---KEL-ENKLATMGTESKA 358
S + + E++ ++ M + ++E E L R+++ EL E++LA + KA
Sbjct: 546 SRKLQEIKEQEYQAQVEEMRLMMNQLE--EDLVSARRRSDLYESELRESRLAAEEFKRKA 603
Query: 359 VSSPSK--KGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS 416
K K + G + + QL + L + +K + + + ++Q+
Sbjct: 604 TECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKAS--TEATELLQN 661
Query: 417 LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVN 476
+ + KE E + + L+ +LE + S H+ + +
Sbjct: 662 IRQ---AKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKE 718
Query: 477 EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLK 536
+ +E++K N KD+ K+ +E + E+ +I + K MI +
Sbjct: 719 Q--HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRS 776
Query: 537 LKQMQKTIDNFSKVSDSN-----KEIVRLTEELHHLSQKVAELEEEKGNL--QLHLVDYD 589
L+Q + +K++ ++ + + E + L Q+ LE + G L Q ++
Sbjct: 777 LEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 836
Query: 590 SGRMIESDVYKKMIEMENLAETRLKAISL-LESQKFDLVQELHILQQKYDEVEDKLADI- 647
++ D K +E ETRL+ +SL E QK +L ++L LQ E E +L +
Sbjct: 837 LEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 894
Query: 648 -------SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD---KEQLYGTIK 697
SQL+ + E + EE+I AL+A + E+ + L+ L +
Sbjct: 895 AARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 954
Query: 698 DLENDKEDIMNK---LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ---SKIQTQF 751
L D ++ N+ L + E D++ ++ +E + L +I E S+ QT
Sbjct: 955 QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE-VDHLRREITEREMQLTSQKQTME 1013
Query: 752 GID---AKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQ- 807
+ ++E+ + +E + EL + K R + E +V+ D + E + +L L
Sbjct: 1014 ALKTTCTMLEEQVMDLEALNDELLE-KER--QWEAWRSVLGDEKSQFECRVRELQRMLDT 1070
Query: 808 EKQ-KAYSEYTIQEDELVNRLAVLMDHDRV--VEKQLLEIEHENKELQKKNQILLEENQN 864
EKQ +A ++ I E V LAV + +++ L E + + + L K L +++
Sbjct: 1071 EKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAM 1130
Query: 865 LQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN-LKRITHEHQTLIVQK-- 921
L+++ +QQ E+ + L E E K Q Q+ DL+ N + R+T Q + +
Sbjct: 1131 LEMNARSLQQKLE--TERELKQRLLE-EQAKLQQQM-DLQKNHIFRLTQGLQEALDRADL 1186
Query: 922 -KKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
K E DLE + I+ +KV K E I T+L LQ
Sbjct: 1187 LKTERSDLEYQLE-NIQVLYSHEKV---KMEGTISQQTKLIDFLQ 1227
Score = 52.0 bits (119), Expect = 2e-05
Identities = 140/709 (19%), Positives = 288/709 (40%), Gaps = 57/709 (8%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
E+ K++ T+ Q + + + K E K + + ++E + LE A + S E
Sbjct: 597 EEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKA-VKASTEA 655
Query: 272 SKLAQELEQXXXXXXXXXXXXXXL--AKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIE 329
++L Q + Q + + I E E+EEK + L ++
Sbjct: 656 TELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLK 715
Query: 330 LLE-HLNCQIR----QTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTA-SKMK 383
E H +I+ Q K+L +K + +KG L +K+ N SK++
Sbjct: 716 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR 775
Query: 384 SPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXX 443
S ++ L++ N + + M Q ++++ + + +K
Sbjct: 776 SLEQRIVE--LSEANKLAANSSLFTQRNMKAQ---EEMISE--LRQQKFYLETQAGKLEA 828
Query: 444 GKDTLIAQLQ-LEHQQHMEGPSLIHVGTNTEDVN-EIAKVQEQLKQELNDEIKDVNVKDL 501
L QL+ + HQ H + L+ + T +V+ E + + +LK++L + +++++
Sbjct: 829 QNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE--LQLSLQER 886
Query: 502 IEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKE----I 557
+L + + L ++ A + + + + +++ + D + D+ + I
Sbjct: 887 ESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI 946
Query: 558 VRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAIS 617
L E+L+ L++ AEL + L L D SG ++ + E+++L +
Sbjct: 947 TDLEEQLNQLTEDNAELNNQNFYLSKQL-DEASGA--NDEIVQLRSEVDHLRREITEREM 1003
Query: 618 LLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
L SQK Q + L+ +E+++ D+ L +D++ K E L K +
Sbjct: 1004 QLTSQK----QTMEALKTTCTMLEEQVMDLEAL-NDELLE--KERQWEAWRSVLGDEKSQ 1056
Query: 678 LALVIENLK--LDKEQLYGTIKD--LENDKEDIMNKLQNYIQENMDLTDKL--EKMSAEK 731
+ L+ LD E+ D + ++ + ++ + E + L L +K+ AE
Sbjct: 1057 FECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 1116
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQ-ERDL---YIEN---IESELSKYKSRICRLEES 784
+S+ L + + + K++ ER+L +E ++ ++ K+ I RL +
Sbjct: 1117 LSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 1176
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYS------EYTI-QEDELVNRLAVLMDHDRVV 837
+ DR L+ + L L+ Q YS E TI Q+ +L++ L MD
Sbjct: 1177 LQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 1236
Query: 838 EKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT 886
+K L E+ L Q+ L+ N+ L+++L + L E +T
Sbjct: 1237 KKGLFSRRKEDPAL--PTQVPLQYNE-LKLALEKEKARCAELEEALQKT 1282
Score = 40.3 bits (90), Expect = 0.056
Identities = 44/244 (18%), Positives = 103/244 (42%), Gaps = 18/244 (7%)
Query: 1356 NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQL-ELKDS 1414
+++ + + EQ + E + LK+S + + E + +L E+K+
Sbjct: 496 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ 555
Query: 1415 EIYQKTHEYTITLTQRNDEFENVRQQ--LVEYEKRIEDLTYEK------ESELAILRLKM 1466
E + E + + Q ++ + R++ L E E R L E+ E + +L+ K
Sbjct: 556 EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKD 615
Query: 1467 H--ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQT 1524
Y ++K + +++K I+EL K+ ++V + + EL + + + +
Sbjct: 616 QGKPEVGEYAKLEKINAEQQLK-IQELQEKLEKAVKASTEATELLQNIRQAKERAERELE 674
Query: 1525 ALENQEIEIVTLNDEITNLQNM------VRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
L+N+E + ++ + + + S+ ++ H+ + + + LDN + K
Sbjct: 675 KLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKK 734
Query: 1579 ELLD 1582
+L D
Sbjct: 735 DLAD 738
>AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 1898
Score = 85.4 bits (202), Expect = 2e-15
Identities = 150/800 (18%), Positives = 345/800 (43%), Gaps = 61/800 (7%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLT 561
EKL++A+E++ + D ++ ++ ++ + + +L++ + ++ K S KE+V +
Sbjct: 508 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 567
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLE 620
E L + + L+ EK + L ++GR+ +E + K E +L ++ K +L E
Sbjct: 568 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 627
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
S D + ++ Q +E Q + + + + LEE +++ L
Sbjct: 628 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 687
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE--KMSAEKISELLAK 738
+ + +E L + L +++ + +L ++ +LE + A++ E L +
Sbjct: 688 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 747
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
E+++ + G+ ++ + E LS+ +R+ RLE+ +E + ++R+
Sbjct: 748 AAREKEALAKEHAGLAVQL----VAAEREGRTLSEEATRL-RLEKE--ALEGSLFEVQRQ 800
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
QL + ++ + + ++ L LA L +++ Q E +KEL Q L
Sbjct: 801 LAQLEARREQLEAEGQALLLAKETLTGELAGL--RQQIIATQ--EKASLDKELMA--QKL 854
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
++ + Q SL + + + +++ R E+ + + + L+S L+R E + L+
Sbjct: 855 VQAEREAQASLREQRAAHEEDLQRLQRE--KEAAWRELEAERAQLQSQLQR---EQEELL 909
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
+ + E E+L E + RD+ +L + EK + ++ E++ + ++
Sbjct: 910 ARLEAEKEELSEEIAALQQE--RDEGLLLAESEKQ-QALSLKESEKTALSEKLMGTRHSL 966
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
++ + +E + Q +Q Q +E+ L A Q++E A Q++ Q
Sbjct: 967 ATIS-LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA---QREEAAAAHAQEVRRLQEQ 1022
Query: 1039 YMSMVSDYESKL---AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ +S L + T+L +E+ + ++LL++++ E Q ++ Q +E
Sbjct: 1023 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ---EGREVQRQEA 1079
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E + + + E + S+ E + + LK+ E++ Q+ +
Sbjct: 1080 GELRRSLGEGAKEREALRRSN--EELRSAVKKAE-------SERISLKLANEDK-EQKLA 1129
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+L+E + E E T + ++E E + ++ +L+ +++ L++EN L
Sbjct: 1130 LLEEARTAVGKEAGELRTGLQEVERSRLEA-------RRELQELRRQMKMLDSENTRLGR 1182
Query: 1216 TVAEL--RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV-------QLSAFES 1266
+AEL R ++ ++ +Q L + EA + EL+V Q F +
Sbjct: 1183 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1242
Query: 1267 KYEQLLDSVQSSTQEETNKI 1286
+ +LL S++ + E ++
Sbjct: 1243 RERRLLGSLEEARGTEKQQL 1262
Score = 81.4 bits (192), Expect = 2e-14
Identities = 145/727 (19%), Positives = 292/727 (40%), Gaps = 69/727 (9%)
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
A LL +K +L L + QQ+ +E+ + + Q + L Q D L
Sbjct: 478 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE----------LRRQRDRLEEE 527
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+++ ++ + E+ + ++ LE + + +L + T + + + AEK +E
Sbjct: 528 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK-AE 586
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR----LEESIAVMED 790
+ + E +++ + + K++ + +++ S+LS + + L +A +E+
Sbjct: 587 VAEALTKAEAGRVELELSM-TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 645
Query: 791 RRYSLE---RKADQLGSYLQEKQKAYSEYTIQEDE----LVNRLAVLMDHDRVVEKQLLE 843
+ +L+ R+A+Q + +E+Q+ E ++++ L L V +E+QL
Sbjct: 646 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 705
Query: 844 IEHENKELQKK----NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+ HE +LQ++ ++ L Q L+ + + Q+ AL A + E Q
Sbjct: 706 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 765
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L E R E T + +K+ +E E Q+ ++ L + + +
Sbjct: 766 LVAAERE-GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET 824
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L +L + I + +E ++ EL+ K VQ ++ EQ L L
Sbjct: 825 LTGELAGLRQQI----IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 880
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++K+ A +++ + S + + +L L +E E + +S+++ +Q
Sbjct: 881 REKE----AAWRELEAERAQLQSQLQREQEEL------LARLEAEKEELSEEIAALQQER 930
Query: 1079 EELQILVREQDDQ---IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD----XX 1131
+E +L + Q +KE ++T L+ ++ + IS +E DA +
Sbjct: 931 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 990
Query: 1132 XXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTG 1187
L+ Q EE QE LQEQ+ L + C + +L T L
Sbjct: 991 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1050
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
D + +E + + + KL + + ELR S+ +R E ++ +
Sbjct: 1051 RDGLRRELL-EAQRKLRESQEGREVQRQEAGELRRSLGEGAKER-----EALRRSNEELR 1104
Query: 1248 ADFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ +K E E R+ L EQ LL+ +++ +E E T LQ + + E
Sbjct: 1105 SAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAG-----ELRTGLQEVERSRLE 1158
Query: 1305 HLRNLQE 1311
R LQE
Sbjct: 1159 ARRELQE 1165
Score = 73.3 bits (172), Expect = 6e-12
Identities = 150/796 (18%), Positives = 317/796 (39%), Gaps = 59/796 (7%)
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++L+ S ++ ++ +Y+ +D L + + SD SE + LEEQ+ L
Sbjct: 402 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSD---SESERRALEEQLQRLRDKT 458
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA--EKIS 733
E+ + + ++L + L +K ++ + LQ Q+ +L + EK+ A E++
Sbjct: 459 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 518
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++ E++ +Q + +++ +E +E + S + + E+++ +R
Sbjct: 519 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 578
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
L+ + ++ L + + E + +L A L D + + + +L +
Sbjct: 579 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 638
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE----------STKYQTQLRD- 902
L EE LQ +Q E+ R + E S + Q ++
Sbjct: 639 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 698
Query: 903 LESNLKRITHEHQTLIVQ----------KKKEIEDLEIEFNTQIES---AIRDKKVLNEK 949
LE L + HE L Q +++E+E E Q+E+ A R+K+ L ++
Sbjct: 699 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE 758
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+ + E + + L + E L E VQ+Q Q EQ
Sbjct: 759 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE-----VQRQLAQLEARREQLEA 813
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E L + E+ L Q+I ++ S + +AQ KL E E Q +
Sbjct: 814 EGQALLLAKETLTGELAGLRQQI----IATQEKASLDKELMAQ---KLVQAEREAQASLR 866
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ H E+LQ L RE++ +EL+ + + + + + ++ + +E ++ + +
Sbjct: 867 E--QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL-ARLEAEKEELSE-E 922
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L + E++ Q S+ + + L+ +L T+ L T++ E+
Sbjct: 923 IAALQQERDEGLLLAESEKQ--QALSLKESEKTALSEKLMG--TR-HSLATISLEMERQK 977
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH-LAQREA 1248
Q + Q +S + L +E +L + E ++ + V + + +L KQ REA
Sbjct: 978 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1037
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD---KEEH 1305
+ +T +LR+ A + +LL++ + + + + V ++ L+ L + + E
Sbjct: 1038 EELRT--QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1095
Query: 1306 LRNLQEKYADVINQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
LR E+ + + E R ++ ++K +LRT Q ++
Sbjct: 1096 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1155
Query: 1363 QEQSILNINEENAQLK 1378
+ ++ + E Q+K
Sbjct: 1156 RLEARRELQELRRQMK 1171
Score = 67.3 bits (157), Expect = 4e-10
Identities = 159/744 (21%), Positives = 312/744 (41%), Gaps = 65/744 (8%)
Query: 536 KLKQMQKTI-DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
KL+ + ++ D+ SK+S N+ + + +L+ L VA+LEEEK LQ + +
Sbjct: 607 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRL---VAQLEEEKSALQGRQRQAEQEATV 663
Query: 595 ESDVYKKMIEM---ENLAETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADIS-Q 649
+ +++ E+ + +A L+ ++ + E + L Q+L L+ + +++++LA +S Q
Sbjct: 664 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 723
Query: 650 LQSDQVCSEIKSVHLEEQIDAL--------SASKKELALVIENLKLDKE--QLYGTIKDL 699
L + E + Q++AL + +K+ L ++ + ++E L L
Sbjct: 724 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 783
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE-EQSKIQTQFGIDAKIQ 758
+KE + L ++ L + E++ AE + LLAK E + ++ Q I A +
Sbjct: 784 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ--IIATQE 841
Query: 759 ERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKADQLGSYLQ-EKQKAYSEY 816
+ L E + +L + + L E A E+ L+R+ + L+ E+ + S+
Sbjct: 842 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 901
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
+++EL+ RL EK+ L E + ++ +LL E++ Q +LS +
Sbjct: 902 QREQEELLARLEA--------EKEELSEEIAALQQERDEGLLLAESEKQQ-ALSLKESEK 952
Query: 877 NALVEK--ANRTDLA----ESESTKYQTQLRDLE--SNLKRITHEHQTLIVQKKKEIEDL 928
AL EK R LA E E K Q R + S + +T E + L Q++ E
Sbjct: 953 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE-EAAAA 1011
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ +++ RD L ++ + + +L QL+ ++ + L + E + E
Sbjct: 1012 HAQEVRRLQEQARD---LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE- 1067
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ ++ Q Q + + E K L++ +EE+ + +K + ++S D E
Sbjct: 1068 -SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1126
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
KLA + +E + L + ++ E + ++E Q+K L + +
Sbjct: 1127 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1186
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+G + + L+V +E + +R LQEQ + T
Sbjct: 1187 LQGRLALGE-RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-LQEQEGEFRTRE 1244
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + E G + + L+ KLE E AEL +S+A
Sbjct: 1245 RRLLGSL-------EEARGTEKQQLDHARGLELKLEAARAE-------AAELGLRLSAAE 1290
Query: 1229 DQ-RGFEIAELWKQHLAQREADFQ 1251
+ +G E AEL + + +R A+ Q
Sbjct: 1291 GRAQGLE-AELARVEVQRRAAEAQ 1313
Score = 58.8 bits (136), Expect = 1e-07
Identities = 172/920 (18%), Positives = 351/920 (38%), Gaps = 74/920 (8%)
Query: 731 KISELLAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKSRICRLEESIAV 787
+++E A+ E+Q+ +Q Q D ++E+DL + ++S+L K E +AV
Sbjct: 228 RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 287
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEKQLLEIE 845
+ +LE+ DQ+ L EK +A +QE + L R + + +L
Sbjct: 288 KRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDS 345
Query: 846 HENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLES 905
+L + N +L+ LS + R+ S + +S
Sbjct: 346 ESGVQLSGSERTADASNGSLR-GLSGQR-----TPSPPRRSSPGRGRSPRRGPSPACSDS 399
Query: 906 NLKRITHEHQTLIVQKKKEIEDL--EIEFNTQIESAIRDKKVLNEKYEKNI--EYVTQLE 961
+ + H + + +++ +++D+ E + + +R K++ + + E+ E + +L
Sbjct: 400 STLALIH---SALHKRQLQVQDMRGRYEASQDLLGTLR-KQLSDSESERRALEEQLQRLR 455
Query: 962 AQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
+ E+ V+ L N EL+ + + S +Q E+ + L+
Sbjct: 456 DKTDGAMQAHEDAQREVQRLRSAN-ELLSRE-KSNLAHSLQVAQQQAEELRQEREKLQAA 513
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ----- 1076
EE+ ++ Q + + +L + +LE +E + ++K+L++ ++
Sbjct: 514 QEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRA 573
Query: 1077 --HNEELQILVREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPMSDDANNVDXXX 1132
+ LQ E + + + + ++ E+++ K E + ++ +S A N
Sbjct: 574 TLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLS--ALNESLAQ 631
Query: 1133 XXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVV 1191
+++EE+ +Q R EQ A + E QE ++ ++ E L G V
Sbjct: 632 DKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRV 691
Query: 1192 NQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ----HLAQRE 1247
++ L+ +L L E L +A+L +S + E +Q A RE
Sbjct: 692 AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE 751
Query: 1248 ADFQKTEHE-LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+ EH L VQL A E + L + +T+ K + +Q +L E
Sbjct: 752 KEALAKEHAGLAVQLVAAEREGRTL---SEEATRLRLEKEALEGSLFEVQRQLAQLEARR 808
Query: 1307 RNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL-RTENQSYKQMQEQ 1365
L+ + ++ E L E+ + L + E ++ ++EQ
Sbjct: 809 EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQ 868
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRV-NDAEAKVLELTHQLELKDSEIYQKTHEYT 1424
+ E+ +L++ ++ + + + EL +LE + E+ E
Sbjct: 869 RAAH-EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL----SEEI 923
Query: 1425 ITLTQRNDE----FENVRQQLVEYEKRIEDLTYEK----ESELAILRLKMHENANHYETM 1476
L Q DE E+ +QQ + ++ + EK LA + L+M ++
Sbjct: 924 AALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR 983
Query: 1477 QKE---------SEIE--RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTA 1525
Q++ SE+ R + E E L +Q +L K + + + E++T
Sbjct: 984 QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1043
Query: 1526 LENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ-----GRDEQLDNTMNKEL 1580
L E L E+ Q +R S + A + ++ ++ + N+EL
Sbjct: 1044 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEEL 1103
Query: 1581 LDAVPRAELDLAMYMLHQRD 1600
AV +AE + L D
Sbjct: 1104 RSAVKKAESERISLKLANED 1123
Score = 55.6 bits (128), Expect = 1e-06
Identities = 130/725 (17%), Positives = 297/725 (40%), Gaps = 51/725 (7%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+EK N LQV + E + +EK+ + + +
Sbjct: 484 REKSNLAHSLQVAQQQAEE-LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 542
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL---EAARFEIS 268
E + +Q+ +++ + E + ++ L + +D+ + E + L EA R E+
Sbjct: 543 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 602
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
L +KL E LA+ ++ + EEK +L+ +
Sbjct: 603 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 662
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
E Q R LE ++A G E + + + + R+ S+++ +Q
Sbjct: 663 VAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 719
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQ--SLNKDLVDKEY-------VISEKD--TXXXX 437
LS + ++ + + + E + ++ + K+ + KE+ V +E++ T
Sbjct: 720 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 779
Query: 438 XXXXXXGKDTL----------IAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
K+ L +AQL+ +Q EG +L+ E+A +++Q+
Sbjct: 780 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL--TGELAGLRQQII 837
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQI-TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
E ++ + + +KL AE + L ++ A +++ +++ + ++++
Sbjct: 838 A--TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 895
Query: 546 NF-SKVSDSNKEIV-RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
S++ +E++ RL E LS+++A L++E+ L L + + + + +K
Sbjct: 896 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE-GLLLAESEKQQALSLKESEKTA 954
Query: 604 EMENLAETR--LKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E L TR L ISL +E QK D +Q V +++ L++ + E
Sbjct: 955 LSEKLMGTRHSLATISLEMERQKRDAQSRQ---EQDRSTVNALTSELRDLRAQR--EEAA 1009
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ H +E + L ++L ++ + E+L ++ LE+ ++ + +L Q +
Sbjct: 1010 AAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE-AQRKLRE 1067
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+ + ++ ++ EL + + + + +E ++ ESE K
Sbjct: 1068 SQEGREVQRQEAGELRRSLGEGAKERE----ALRRSNEELRSAVKKAESERISLKLANED 1123
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E+ +A++E+ R ++ ++A +L + LQE +++ E + EL ++ +L + + ++
Sbjct: 1124 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE 1183
Query: 841 LLEIE 845
L E++
Sbjct: 1184 LAELQ 1188
Score = 40.3 bits (90), Expect = 0.056
Identities = 70/378 (18%), Positives = 166/378 (43%), Gaps = 23/378 (6%)
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT----QLNDEIDAANKNMIKVK 530
++++A ++ L Q E++ K I K+K+ E ++ +L + +DA+ +K++
Sbjct: 1480 LDQVATLERSL-QATESELRASQEK--ISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1536
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ ++Q++ +SD + L + + L ++VA+ E + G LQL V+ +
Sbjct: 1537 LQRRSLEGELQRSRLG---LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL-TVERLN 1592
Query: 591 GRM--IESDVYKKMIEMENLAETRLKAISLLES---QKFDLVQELHILQQKYDEVEDKLA 645
G + +E ++ L E ++ + L S + L + L + ++++L
Sbjct: 1593 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1652
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q S+ + +S L EQ+ L +L L + +QL ++ + +
Sbjct: 1653 AARQALSE---ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1709
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD-LYI 764
+N +Q E L ++L + +++L A+ E+S ++ + A + D +
Sbjct: 1710 ALNTVQKLQDERRLLQERLGSLQ-RALAQLEAEKREVERSALRLEKDRVALRRTLDKVER 1768
Query: 765 ENIES--ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E + S + + + RL+ ++ E +R+ QL + + ++++S ++ D
Sbjct: 1769 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1828
Query: 823 LVNRLAVLMDHDRVVEKQ 840
+L + + +R+ Q
Sbjct: 1829 QQQQLELQQEVERLRSAQ 1846
Score = 38.7 bits (86), Expect = 0.17
Identities = 64/350 (18%), Positives = 143/350 (40%), Gaps = 32/350 (9%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ + +L E D L + + L ++ +R + A + L + A+ ++
Sbjct: 1392 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAER--DSATSRARQLQKAVAESEEARR 1449
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ +LS +++ +SV+ S +E T++QV +L+ LQ E LR QEK
Sbjct: 1450 SVDGRLSGVQAELALQEESVRRSERERR---ATLDQVATLERSLQATESELRASQEK--- 1503
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
I++++ +++E +K L + +S + ++S L +++ A
Sbjct: 1504 -ISKMKANETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1558
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAK--VLELT--------HQLELKDSEIYQKTHEYTI 1425
Q + +V D+E K L+LT ++E + + K T
Sbjct: 1559 Q----AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1614
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEI 1482
L Q + + R + + +K + +++ + L R + E ++ ++ +
Sbjct: 1615 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1674
Query: 1483 ERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEI 1531
R + + +L ++ E+ +Q+ E L + E E A N +Q + + +
Sbjct: 1675 LRGE-VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1723
>AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 2017
Score = 85.4 bits (202), Expect = 2e-15
Identities = 150/800 (18%), Positives = 345/800 (43%), Gaps = 61/800 (7%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLT 561
EKL++A+E++ + D ++ ++ ++ + + +L++ + ++ K S KE+V +
Sbjct: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLE 620
E L + + L+ EK + L ++GR+ +E + K E +L ++ K +L E
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
S D + ++ Q +E Q + + + + LEE +++ L
Sbjct: 747 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE--KMSAEKISELLAK 738
+ + +E L + L +++ + +L ++ +LE + A++ E L +
Sbjct: 807 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 866
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
E+++ + G+ ++ + E LS+ +R+ RLE+ +E + ++R+
Sbjct: 867 AAREKEALAKEHAGLAVQL----VAAEREGRTLSEEATRL-RLEKE--ALEGSLFEVQRQ 919
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
QL + ++ + + ++ L LA L +++ Q E +KEL Q L
Sbjct: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGL--RQQIIATQ--EKASLDKELMA--QKL 973
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
++ + Q SL + + + +++ R E+ + + + L+S L+R E + L+
Sbjct: 974 VQAEREAQASLREQRAAHEEDLQRLQRE--KEAAWRELEAERAQLQSQLQR---EQEELL 1028
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
+ + E E+L E + RD+ +L + EK + ++ E++ + ++
Sbjct: 1029 ARLEAEKEELSEEIAALQQE--RDEGLLLAESEKQ-QALSLKESEKTALSEKLMGTRHSL 1085
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
++ + +E + Q +Q Q +E+ L A Q++E A Q++ Q
Sbjct: 1086 ATIS-LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA---QREEAAAAHAQEVRRLQEQ 1141
Query: 1039 YMSMVSDYESKL---AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ +S L + T+L +E+ + ++LL++++ E Q ++ Q +E
Sbjct: 1142 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ---EGREVQRQEA 1198
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E + + + E + S+ E + + LK+ E++ Q+ +
Sbjct: 1199 GELRRSLGEGAKEREALRRSN--EELRSAVKKAE-------SERISLKLANEDK-EQKLA 1248
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+L+E + E E T + ++E E + ++ +L+ +++ L++EN L
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEA-------RRELQELRRQMKMLDSENTRLGR 1301
Query: 1216 TVAEL--RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV-------QLSAFES 1266
+AEL R ++ ++ +Q L + EA + EL+V Q F +
Sbjct: 1302 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1361
Query: 1267 KYEQLLDSVQSSTQEETNKI 1286
+ +LL S++ + E ++
Sbjct: 1362 RERRLLGSLEEARGTEKQQL 1381
Score = 81.4 bits (192), Expect = 2e-14
Identities = 145/727 (19%), Positives = 292/727 (40%), Gaps = 69/727 (9%)
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
A LL +K +L L + QQ+ +E+ + + Q + L Q D L
Sbjct: 597 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE----------LRRQRDRLEEE 646
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+++ ++ + E+ + ++ LE + + +L + T + + + AEK +E
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK-AE 705
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR----LEESIAVMED 790
+ + E +++ + + K++ + +++ S+LS + + L +A +E+
Sbjct: 706 VAEALTKAEAGRVELELSM-TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764
Query: 791 RRYSLE---RKADQLGSYLQEKQKAYSEYTIQEDE----LVNRLAVLMDHDRVVEKQLLE 843
+ +L+ R+A+Q + +E+Q+ E ++++ L L V +E+QL
Sbjct: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 824
Query: 844 IEHENKELQKK----NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+ HE +LQ++ ++ L Q L+ + + Q+ AL A + E Q
Sbjct: 825 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L E R E T + +K+ +E E Q+ ++ L + + +
Sbjct: 885 LVAAERE-GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET 943
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L +L + I + +E ++ EL+ K VQ ++ EQ L L
Sbjct: 944 LTGELAGLRQQI----IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 999
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++K+ A +++ + S + + +L L +E E + +S+++ +Q
Sbjct: 1000 REKE----AAWRELEAERAQLQSQLQREQEEL------LARLEAEKEELSEEIAALQQER 1049
Query: 1079 EELQILVREQDDQ---IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD----XX 1131
+E +L + Q +KE ++T L+ ++ + IS +E DA +
Sbjct: 1050 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 1109
Query: 1132 XXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTG 1187
L+ Q EE QE LQEQ+ L + C + +L T L
Sbjct: 1110 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
D + +E + + + KL + + ELR S+ +R E ++ +
Sbjct: 1170 RDGLRRELL-EAQRKLRESQEGREVQRQEAGELRRSLGEGAKER-----EALRRSNEELR 1223
Query: 1248 ADFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ +K E E R+ L EQ LL+ +++ +E E T LQ + + E
Sbjct: 1224 SAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAG-----ELRTGLQEVERSRLE 1277
Query: 1305 HLRNLQE 1311
R LQE
Sbjct: 1278 ARRELQE 1284
Score = 73.3 bits (172), Expect = 6e-12
Identities = 150/796 (18%), Positives = 317/796 (39%), Gaps = 59/796 (7%)
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++L+ S ++ ++ +Y+ +D L + + SD SE + LEEQ+ L
Sbjct: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSD---SESERRALEEQLQRLRDKT 577
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA--EKIS 733
E+ + + ++L + L +K ++ + LQ Q+ +L + EK+ A E++
Sbjct: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 637
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++ E++ +Q + +++ +E +E + S + + E+++ +R
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 697
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
L+ + ++ L + + E + +L A L D + + + +L +
Sbjct: 698 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 757
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE----------STKYQTQLRD- 902
L EE LQ +Q E+ R + E S + Q ++
Sbjct: 758 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 817
Query: 903 LESNLKRITHEHQTLIVQ----------KKKEIEDLEIEFNTQIES---AIRDKKVLNEK 949
LE L + HE L Q +++E+E E Q+E+ A R+K+ L ++
Sbjct: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE 877
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+ + E + + L + E L E VQ+Q Q EQ
Sbjct: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE-----VQRQLAQLEARREQLEA 932
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E L + E+ L Q+I ++ S + +AQ KL E E Q +
Sbjct: 933 EGQALLLAKETLTGELAGLRQQI----IATQEKASLDKELMAQ---KLVQAEREAQASLR 985
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ H E+LQ L RE++ +EL+ + + + + + ++ + +E ++ + +
Sbjct: 986 E--QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL-ARLEAEKEELSE-E 1041
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L + E++ Q S+ + + L+ +L T+ L T++ E+
Sbjct: 1042 IAALQQERDEGLLLAESEKQ--QALSLKESEKTALSEKLMG--TR-HSLATISLEMERQK 1096
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH-LAQREA 1248
Q + Q +S + L +E +L + E ++ + V + + +L KQ REA
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1156
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD---KEEH 1305
+ +T +LR+ A + +LL++ + + + + V ++ L+ L + + E
Sbjct: 1157 EELRT--QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1214
Query: 1306 LRNLQEKYADVINQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
LR E+ + + E R ++ ++K +LRT Q ++
Sbjct: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
Query: 1363 QEQSILNINEENAQLK 1378
+ ++ + E Q+K
Sbjct: 1275 RLEARRELQELRRQMK 1290
Score = 67.3 bits (157), Expect = 4e-10
Identities = 159/744 (21%), Positives = 312/744 (41%), Gaps = 65/744 (8%)
Query: 536 KLKQMQKTI-DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
KL+ + ++ D+ SK+S N+ + + +L+ L VA+LEEEK LQ + +
Sbjct: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRL---VAQLEEEKSALQGRQRQAEQEATV 782
Query: 595 ESDVYKKMIEM---ENLAETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADIS-Q 649
+ +++ E+ + +A L+ ++ + E + L Q+L L+ + +++++LA +S Q
Sbjct: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
Query: 650 LQSDQVCSEIKSVHLEEQIDAL--------SASKKELALVIENLKLDKE--QLYGTIKDL 699
L + E + Q++AL + +K+ L ++ + ++E L L
Sbjct: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE-EQSKIQTQFGIDAKIQ 758
+KE + L ++ L + E++ AE + LLAK E + ++ Q I A +
Sbjct: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ--IIATQE 960
Query: 759 ERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKADQLGSYLQ-EKQKAYSEY 816
+ L E + +L + + L E A E+ L+R+ + L+ E+ + S+
Sbjct: 961 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
+++EL+ RL EK+ L E + ++ +LL E++ Q +LS +
Sbjct: 1021 QREQEELLARLEA--------EKEELSEEIAALQQERDEGLLLAESEKQQ-ALSLKESEK 1071
Query: 877 NALVEK--ANRTDLA----ESESTKYQTQLRDLE--SNLKRITHEHQTLIVQKKKEIEDL 928
AL EK R LA E E K Q R + S + +T E + L Q++ E
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE-EAAAA 1130
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ +++ RD L ++ + + +L QL+ ++ + L + E + E
Sbjct: 1131 HAQEVRRLQEQARD---LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE- 1186
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ ++ Q Q + + E K L++ +EE+ + +K + ++S D E
Sbjct: 1187 -SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1245
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
KLA + +E + L + ++ E + ++E Q+K L + +
Sbjct: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+G + + L+V +E + +R LQEQ + T
Sbjct: 1306 LQGRLALGE-RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-LQEQEGEFRTRE 1363
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + E G + + L+ KLE E AEL +S+A
Sbjct: 1364 RRLLGSL-------EEARGTEKQQLDHARGLELKLEAARAE-------AAELGLRLSAAE 1409
Query: 1229 DQ-RGFEIAELWKQHLAQREADFQ 1251
+ +G E AEL + + +R A+ Q
Sbjct: 1410 GRAQGLE-AELARVEVQRRAAEAQ 1432
Score = 61.3 bits (142), Expect = 3e-08
Identities = 229/1263 (18%), Positives = 485/1263 (38%), Gaps = 107/1263 (8%)
Query: 410 LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVG 469
LE VIQ+L ++ +E + +D LI ++ + E P L+
Sbjct: 15 LETVIQTLESSVLCQEKGLGARDLAQDAQITSL---PALIREIVTRNLSQPESPVLLPA- 70
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE------KLKSAEEQITQL----NDEI 519
T + + + + L+QEL+ ++D+ + E K + E++ Q E+
Sbjct: 71 TEMASLLSLQEENQLLQQELS-RVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGEL 129
Query: 520 DAAN-KNMIKVKSNHKLKLKQMQ----KTIDNFSKVSDSNKEIV-RLTEELHHLSQKVAE 573
+ + +++ + +L++ Q + + + + ++V RL ++ ++ +E
Sbjct: 130 ETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSE 189
Query: 574 LE----EEKGNL-QLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQ 628
LE E G L Q L D + + +ES + + +E E L ++ + ++ D
Sbjct: 190 LEQQLLERSGELEQQRLRDTEHSQDLESALIR--LEEEQQRSASLAQVNAMLREQLDQAG 247
Query: 629 ELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLD 688
+ Q +++ D ++ + + E EE +A +++ L++ +
Sbjct: 248 SAN--QALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVG 305
Query: 689 KEQLYGTIKDL-ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKI 747
+L +K E D + +L + + L + +++E A+ E+Q+ +
Sbjct: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAG--LGLSTGLRLAESRAEAALEKQALL 363
Query: 748 QTQFGI---DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGS 804
Q Q D ++E+DL + ++S+L K E +AV + +LE+ DQ+
Sbjct: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNK 421
Query: 805 YLQEKQKAYSEYTIQEDELVNRL--AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEEN 862
L EK +A +QE + L R + + +L +L + N
Sbjct: 422 DLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASN 481
Query: 863 QNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK 922
+L+ LS + R+ S + +S+ + H + + +++
Sbjct: 482 GSLR-GLSGQR-----TPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIH---SALHKRQ 532
Query: 923 KEIEDL--EIEFNTQIESAIRDKKVLNEKYEKNI--EYVTQLEAQLQEYKNNIENLNMNV 978
+++D+ E + + +R K++ + + E+ E + +L + E+ V
Sbjct: 533 LQVQDMRGRYEASQDLLGTLR-KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREV 591
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
+ L N EL+ + + S +Q E+ + L+ EE+ ++ Q
Sbjct: 592 QRLRSAN-ELLSRE-KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
Query: 1039 YMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQ-------HNEELQILVREQDDQ 1091
+ + +L + +LE +E + ++K+L++ ++ + LQ E +
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 1092 IKELKETKLTFEMNIPK--TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEE 1149
+ + + ++ E+++ K E + ++ +S A N +++EE+
Sbjct: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLS--ALNESLAQDKLDLNRLVAQLEEEKS 767
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
+Q R EQ A + E QE ++ ++ E L G V ++ L+ +L L
Sbjct: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
Query: 1209 ENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ----HLAQREADFQKTEHE-LRVQLSA 1263
E L +A+L +S + E +Q A RE + EH L VQL A
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 1264 FESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEIL 1323
E + L + +T+ K + +Q +L E L+ + ++ E L
Sbjct: 888 AEREGRTL---SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL 944
Query: 1324 RSEIEDEKVAFXXXXXXXXXXXXXXXXDL-RTENQSYKQMQEQSILNINEENAQLKKSSX 1382
E+ + L + E ++ ++EQ + E+ +L++
Sbjct: 945 TGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH-EEDLQRLQREKE 1003
Query: 1383 XXXXXXXXXXXRV-NDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE----FENV 1437
++ + + + EL +LE + E+ E L Q DE E+
Sbjct: 1004 AAWRELEAERAQLQSQLQREQEELLARLEAEKEEL----SEEIAALQQERDEGLLLAESE 1059
Query: 1438 RQQLVEYEKRIEDLTYEK----ESELAILRLKMHENANHYETMQKE---------SEIE- 1483
+QQ + ++ + EK LA + L+M ++ Q++ SE+
Sbjct: 1060 KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119
Query: 1484 -RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITN 1542
R + E E L +Q +L K + + + E++T L E L E+
Sbjct: 1120 LRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
Query: 1543 LQNMVRASSSKIQKHVSFASDTKQ-----GRDEQLDNTMNKELLDAVPRAELDLAMYMLH 1597
Q +R S + A + ++ ++ + N+EL AV +AE + L
Sbjct: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
Query: 1598 QRD 1600
D
Sbjct: 1240 NED 1242
Score = 55.6 bits (128), Expect = 1e-06
Identities = 130/725 (17%), Positives = 297/725 (40%), Gaps = 51/725 (7%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+EK N LQV + E + +EK+ + + +
Sbjct: 603 REKSNLAHSLQVAQQQAEE-LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL---EAARFEIS 268
E + +Q+ +++ + E + ++ L + +D+ + E + L EA R E+
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
L +KL E LA+ ++ + EEK +L+ +
Sbjct: 722 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
E Q R LE ++A G E + + + + R+ S+++ +Q
Sbjct: 782 VAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQ--SLNKDLVDKEY-------VISEKD--TXXXX 437
LS + ++ + + + E + ++ + K+ + KE+ V +E++ T
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 438 XXXXXXGKDTL----------IAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
K+ L +AQL+ +Q EG +L+ E+A +++Q+
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL--TGELAGLRQQII 956
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQI-TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
E ++ + + +KL AE + L ++ A +++ +++ + ++++
Sbjct: 957 A--TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
Query: 546 NF-SKVSDSNKEIV-RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
S++ +E++ RL E LS+++A L++E+ L L + + + + +K
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE-GLLLAESEKQQALSLKESEKTA 1073
Query: 604 EMENLAETR--LKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E L TR L ISL +E QK D +Q V +++ L++ + E
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQ---EQDRSTVNALTSELRDLRAQR--EEAA 1128
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ H +E + L ++L ++ + E+L ++ LE+ ++ + +L Q +
Sbjct: 1129 AAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE-AQRKLRE 1186
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+ + ++ ++ EL + + + + +E ++ ESE K
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKERE----ALRRSNEELRSAVKKAESERISLKLANED 1242
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E+ +A++E+ R ++ ++A +L + LQE +++ E + EL ++ +L + + ++
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE 1302
Query: 841 LLEIE 845
L E++
Sbjct: 1303 LAELQ 1307
Score = 40.3 bits (90), Expect = 0.056
Identities = 70/378 (18%), Positives = 166/378 (43%), Gaps = 23/378 (6%)
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT----QLNDEIDAANKNMIKVK 530
++++A ++ L Q E++ K I K+K+ E ++ +L + +DA+ +K++
Sbjct: 1599 LDQVATLERSL-QATESELRASQEK--ISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ ++Q++ +SD + L + + L ++VA+ E + G LQL V+ +
Sbjct: 1656 LQRRSLEGELQRSRLG---LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL-TVERLN 1711
Query: 591 GRM--IESDVYKKMIEMENLAETRLKAISLLES---QKFDLVQELHILQQKYDEVEDKLA 645
G + +E ++ L E ++ + L S + L + L + ++++L
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q S+ + +S L EQ+ L +L L + +QL ++ + +
Sbjct: 1772 AARQALSE---ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1828
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD-LYI 764
+N +Q E L ++L + +++L A+ E+S ++ + A + D +
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQ-RALAQLEAEKREVERSALRLEKDRVALRRTLDKVER 1887
Query: 765 ENIES--ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E + S + + + RL+ ++ E +R+ QL + + ++++S ++ D
Sbjct: 1888 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1947
Query: 823 LVNRLAVLMDHDRVVEKQ 840
+L + + +R+ Q
Sbjct: 1948 QQQQLELQQEVERLRSAQ 1965
Score = 38.7 bits (86), Expect = 0.17
Identities = 64/350 (18%), Positives = 143/350 (40%), Gaps = 32/350 (9%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ + +L E D L + + L ++ +R + A + L + A+ ++
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAER--DSATSRARQLQKAVAESEEARR 1568
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ +LS +++ +SV+ S +E T++QV +L+ LQ E LR QEK
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERR---ATLDQVATLERSLQATESELRASQEK--- 1622
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
I++++ +++E +K L + +S + ++S L +++ A
Sbjct: 1623 -ISKMKANETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1677
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAK--VLELT--------HQLELKDSEIYQKTHEYTI 1425
Q + +V D+E K L+LT ++E + + K T
Sbjct: 1678 Q----AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEI 1482
L Q + + R + + +K + +++ + L R + E ++ ++ +
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793
Query: 1483 ERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEI 1531
R + + +L ++ E+ +Q+ E L + E E A N +Q + + +
Sbjct: 1794 LRGE-VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1842
>AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein.
Length = 1919
Score = 85.4 bits (202), Expect = 2e-15
Identities = 150/800 (18%), Positives = 345/800 (43%), Gaps = 61/800 (7%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLT 561
EKL++A+E++ + D ++ ++ ++ + + +L++ + ++ K S KE+V +
Sbjct: 529 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 588
Query: 562 EELHHLSQKVAELEEEKGNLQLHLVDYDSGRM-IESDVYKKMIEMENLAETRLKAISLLE 620
E L + + L+ EK + L ++GR+ +E + K E +L ++ K +L E
Sbjct: 589 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 648
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL 680
S D + ++ Q +E Q + + + + LEE +++ L
Sbjct: 649 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 708
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLE--KMSAEKISELLAK 738
+ + +E L + L +++ + +L ++ +LE + A++ E L +
Sbjct: 709 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 768
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
E+++ + G+ ++ + E LS+ +R+ RLE+ +E + ++R+
Sbjct: 769 AAREKEALAKEHAGLAVQL----VAAEREGRTLSEEATRL-RLEKE--ALEGSLFEVQRQ 821
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
QL + ++ + + ++ L LA L +++ Q E +KEL Q L
Sbjct: 822 LAQLEARREQLEAEGQALLLAKETLTGELAGL--RQQIIATQ--EKASLDKELMA--QKL 875
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
++ + Q SL + + + +++ R E+ + + + L+S L+R E + L+
Sbjct: 876 VQAEREAQASLREQRAAHEEDLQRLQRE--KEAAWRELEAERAQLQSQLQR---EQEELL 930
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
+ + E E+L E + RD+ +L + EK + ++ E++ + ++
Sbjct: 931 ARLEAEKEELSEEIAALQQE--RDEGLLLAESEKQ-QALSLKESEKTALSEKLMGTRHSL 987
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS 1038
++ + +E + Q +Q Q +E+ L A Q++E A Q++ Q
Sbjct: 988 ATIS-LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA---QREEAAAAHAQEVRRLQEQ 1043
Query: 1039 YMSMVSDYESKL---AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL 1095
+ +S L + T+L +E+ + ++LL++++ E Q ++ Q +E
Sbjct: 1044 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ---EGREVQRQEA 1100
Query: 1096 KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
E + + + E + S+ E + + LK+ E++ Q+ +
Sbjct: 1101 GELRRSLGEGAKEREALRRSN--EELRSAVKKAE-------SERISLKLANEDK-EQKLA 1150
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+L+E + E E T + ++E E + ++ +L+ +++ L++EN L
Sbjct: 1151 LLEEARTAVGKEAGELRTGLQEVERSRLEA-------RRELQELRRQMKMLDSENTRLGR 1203
Query: 1216 TVAEL--RSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV-------QLSAFES 1266
+AEL R ++ ++ +Q L + EA + EL+V Q F +
Sbjct: 1204 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1263
Query: 1267 KYEQLLDSVQSSTQEETNKI 1286
+ +LL S++ + E ++
Sbjct: 1264 RERRLLGSLEEARGTEKQQL 1283
Score = 81.4 bits (192), Expect = 2e-14
Identities = 145/727 (19%), Positives = 292/727 (40%), Gaps = 69/727 (9%)
Query: 615 AISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSAS 674
A LL +K +L L + QQ+ +E+ + + Q + L Q D L
Sbjct: 499 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE----------LRRQRDRLEEE 548
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE 734
+++ ++ + E+ + ++ LE + + +L + T + + + AEK +E
Sbjct: 549 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK-AE 607
Query: 735 LLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR----LEESIAVMED 790
+ + E +++ + + K++ + +++ S+LS + + L +A +E+
Sbjct: 608 VAEALTKAEAGRVELELSM-TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 666
Query: 791 RRYSLE---RKADQLGSYLQEKQKAYSEYTIQEDE----LVNRLAVLMDHDRVVEKQLLE 843
+ +L+ R+A+Q + +E+Q+ E ++++ L L V +E+QL
Sbjct: 667 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 726
Query: 844 IEHENKELQKK----NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQ 899
+ HE +LQ++ ++ L Q L+ + + Q+ AL A + E Q
Sbjct: 727 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 786
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
L E R E T + +K+ +E E Q+ ++ L + + +
Sbjct: 787 LVAAERE-GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKET 845
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELI-DKHVQKQQTQSPDYTEQYINEINKLNALL 1018
L +L + I + +E ++ EL+ K VQ ++ EQ L L
Sbjct: 846 LTGELAGLRQQI----IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 901
Query: 1019 KQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHN 1078
++K+ A +++ + S + + +L L +E E + +S+++ +Q
Sbjct: 902 REKE----AAWRELEAERAQLQSQLQREQEEL------LARLEAEKEELSEEIAALQQER 951
Query: 1079 EELQILVREQDDQ---IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD----XX 1131
+E +L + Q +KE ++T L+ ++ + IS +E DA +
Sbjct: 952 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 1011
Query: 1132 XXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKIIQLET-LNTELTG 1187
L+ Q EE QE LQEQ+ L + C + +L T L
Sbjct: 1012 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1071
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQRE 1247
D + +E + + + KL + + ELR S+ +R E ++ +
Sbjct: 1072 RDGLRRELL-EAQRKLRESQEGREVQRQEAGELRRSLGEGAKER-----EALRRSNEELR 1125
Query: 1248 ADFQKTEHELRVQLSAFESKYEQ---LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEE 1304
+ +K E E R+ L EQ LL+ +++ +E E T LQ + + E
Sbjct: 1126 SAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAG-----ELRTGLQEVERSRLE 1179
Query: 1305 HLRNLQE 1311
R LQE
Sbjct: 1180 ARRELQE 1186
Score = 73.3 bits (172), Expect = 6e-12
Identities = 150/796 (18%), Positives = 317/796 (39%), Gaps = 59/796 (7%)
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
++L+ S ++ ++ +Y+ +D L + + SD SE + LEEQ+ L
Sbjct: 423 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSD---SESERRALEEQLQRLRDKT 479
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSA--EKIS 733
E+ + + ++L + L +K ++ + LQ Q+ +L + EK+ A E++
Sbjct: 480 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 539
Query: 734 ELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRY 793
++ E++ +Q + +++ +E +E + S + + E+++ +R
Sbjct: 540 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 599
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
L+ + ++ L + + E + +L A L D + + + +L +
Sbjct: 600 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 659
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE----------STKYQTQLRD- 902
L EE LQ +Q E+ R + E S + Q ++
Sbjct: 660 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 719
Query: 903 LESNLKRITHEHQTLIVQ----------KKKEIEDLEIEFNTQIES---AIRDKKVLNEK 949
LE L + HE L Q +++E+E E Q+E+ A R+K+ L ++
Sbjct: 720 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE 779
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
+ + E + + L + E L E VQ+Q Q EQ
Sbjct: 780 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE-----VQRQLAQLEARREQLEA 834
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
E L + E+ L Q+I ++ S + +AQ KL E E Q +
Sbjct: 835 EGQALLLAKETLTGELAGLRQQI----IATQEKASLDKELMAQ---KLVQAEREAQASLR 887
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ H E+LQ L RE++ +EL+ + + + + + ++ + +E ++ + +
Sbjct: 888 E--QRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL-ARLEAEKEELSE-E 943
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
L + E++ Q S+ + + L+ +L T+ L T++ E+
Sbjct: 944 IAALQQERDEGLLLAESEKQ--QALSLKESEKTALSEKLMG--TR-HSLATISLEMERQK 998
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQH-LAQREA 1248
Q + Q +S + L +E +L + E ++ + V + + +L KQ REA
Sbjct: 999 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1058
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD---KEEH 1305
+ +T +LR+ A + +LL++ + + + + V ++ L+ L + + E
Sbjct: 1059 EELRT--QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1116
Query: 1306 LRNLQEKYADVINQIEILRSEIE---DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
LR E+ + + E R ++ ++K +LRT Q ++
Sbjct: 1117 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1176
Query: 1363 QEQSILNINEENAQLK 1378
+ ++ + E Q+K
Sbjct: 1177 RLEARRELQELRRQMK 1192
Score = 67.3 bits (157), Expect = 4e-10
Identities = 159/744 (21%), Positives = 312/744 (41%), Gaps = 65/744 (8%)
Query: 536 KLKQMQKTI-DNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
KL+ + ++ D+ SK+S N+ + + +L+ L VA+LEEEK LQ + +
Sbjct: 628 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRL---VAQLEEEKSALQGRQRQAEQEATV 684
Query: 595 ESDVYKKMIEM---ENLAETRLK-AISLLESQKFDLVQELHILQQKYDEVEDKLADIS-Q 649
+ +++ E+ + +A L+ ++ + E + L Q+L L+ + +++++LA +S Q
Sbjct: 685 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 744
Query: 650 LQSDQVCSEIKSVHLEEQIDAL--------SASKKELALVIENLKLDKE--QLYGTIKDL 699
L + E + Q++AL + +K+ L ++ + ++E L L
Sbjct: 745 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 804
Query: 700 ENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE-EQSKIQTQFGIDAKIQ 758
+KE + L ++ L + E++ AE + LLAK E + ++ Q I A +
Sbjct: 805 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ--IIATQE 862
Query: 759 ERDLYIENIESELSKYKSRI-CRLEESIAVMEDRRYSLERKADQLGSYLQ-EKQKAYSEY 816
+ L E + +L + + L E A E+ L+R+ + L+ E+ + S+
Sbjct: 863 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 922
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHY 876
+++EL+ RL EK+ L E + ++ +LL E++ Q +LS +
Sbjct: 923 QREQEELLARLEA--------EKEELSEEIAALQQERDEGLLLAESEKQQ-ALSLKESEK 973
Query: 877 NALVEK--ANRTDLA----ESESTKYQTQLRDLE--SNLKRITHEHQTLIVQKKKEIEDL 928
AL EK R LA E E K Q R + S + +T E + L Q++ E
Sbjct: 974 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE-EAAAA 1032
Query: 929 EIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLEL 988
+ +++ RD L ++ + + +L QL+ ++ + L + E + E
Sbjct: 1033 HAQEVRRLQEQARD---LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE- 1088
Query: 989 IDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES 1048
+ ++ Q Q + + E K L++ +EE+ + +K + ++S D E
Sbjct: 1089 -SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1147
Query: 1049 KLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
KLA + +E + L + ++ E + ++E Q+K L + +
Sbjct: 1148 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1207
Query: 1109 TEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTEL 1168
+G + + L+V +E + +R LQEQ + T
Sbjct: 1208 LQGRLALGE-RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-LQEQEGEFRTRE 1265
Query: 1169 QECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAV 1228
+ + E G + + L+ KLE E AEL +S+A
Sbjct: 1266 RRLLGSL-------EEARGTEKQQLDHARGLELKLEAARAE-------AAELGLRLSAAE 1311
Query: 1229 DQ-RGFEIAELWKQHLAQREADFQ 1251
+ +G E AEL + + +R A+ Q
Sbjct: 1312 GRAQGLE-AELARVEVQRRAAEAQ 1334
Score = 60.5 bits (140), Expect = 5e-08
Identities = 212/1171 (18%), Positives = 451/1171 (38%), Gaps = 93/1171 (7%)
Query: 481 VQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
V E+L+Q L E ++ ++ ++ + E QL +E A+ + ++ + + Q+
Sbjct: 16 VSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEE-QASYRRKLQAYQEGQQRQAQL 74
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYK 600
+ + K+ K L ++L ++ ELE+++ L D + + +ES + +
Sbjct: 75 VQRLQG--KILQYKKRCSELEQQL---LERSGELEQQR------LRDTEHSQDLESALIR 123
Query: 601 KMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
+E E L ++ + ++ D + Q +++ D ++ + + E
Sbjct: 124 --LEEEQQRSASLAQVNAMLREQLDQAGSAN--QALSEDIRKVTNDWTRCRKELEHREAA 179
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNKLQNYIQENMD 719
EE +A +++ L++ + +L +K E D + +L + +
Sbjct: 180 WRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQE 239
Query: 720 LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI---DAKIQERDLYIENIESELSKYKS 776
L + +++E A+ E+Q+ +Q Q D ++E+DL + ++S+L K
Sbjct: 240 AG--LGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADL 297
Query: 777 RICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL--AVLMDHD 834
E +AV + +LE+ DQ+ L EK +A +QE + L
Sbjct: 298 SARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTL 355
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
R + + +L +L + N +L+ LS + R+ S
Sbjct: 356 RDLAQAVLSDSESGVQLSGSERTADASNGSLR-GLSGQR-----TPSPPRRSSPGRGRSP 409
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL--EIEFNTQIESAIRDKKVLNEKYEK 952
+ +S+ + H + + +++ +++D+ E + + +R K++ + + E+
Sbjct: 410 RRGPSPACSDSSTLALIH---SALHKRQLQVQDMRGRYEASQDLLGTLR-KQLSDSESER 465
Query: 953 NI--EYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE 1010
E + +L + E+ V+ L N EL+ + + S +Q E
Sbjct: 466 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSAN-ELLSRE-KSNLAHSLQVAQQQAEE 523
Query: 1011 INKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQ 1070
+ + L+ EE+ ++ Q + + +L + +LE +E + ++K+
Sbjct: 524 LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKE 583
Query: 1071 LLDSKQ-------HNEELQILVREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPM 1121
L++ ++ + LQ E + + + + ++ E+++ K E + ++ +
Sbjct: 584 LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKL 643
Query: 1122 SDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI-IQLET 1180
S A N +++EE+ +Q R EQ A + E QE ++ ++ E
Sbjct: 644 S--ALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEV 701
Query: 1181 LNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK 1240
L G V ++ L+ +L L E L +A+L +S + E +
Sbjct: 702 ARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 761
Query: 1241 Q----HLAQREADFQKTEHE-LRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSL 1295
Q A RE + EH L VQL A E + L + +T+ K + +
Sbjct: 762 QVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL---SEEATRLRLEKEALEGSLFEV 818
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDL-RT 1354
Q +L E L+ + ++ E L E+ + L +
Sbjct: 819 QRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQA 878
Query: 1355 ENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV-NDAEAKVLELTHQLELKD 1413
E ++ ++EQ + E+ +L++ ++ + + + EL +LE +
Sbjct: 879 EREAQASLREQRAAH-EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEK 937
Query: 1414 SEIYQKTHEYTITLTQRNDE----FENVRQQLVEYEKRIEDLTYEK----ESELAILRLK 1465
E+ E L Q DE E+ +QQ + ++ + EK LA + L+
Sbjct: 938 EEL----SEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 993
Query: 1466 MHENANHYETMQKE---------SEIE--RVKLIEELNVKITESVSLNKQVAELNKALEE 1514
M ++ Q++ SE+ R + E E L +Q +L K +
Sbjct: 994 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1053
Query: 1515 EVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQ-----GRD 1569
+ + E++T L E L E+ Q +R S + A + ++ ++
Sbjct: 1054 CLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKE 1113
Query: 1570 EQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
+ N+EL AV +AE + L D
Sbjct: 1114 REALRRSNEELRSAVKKAESERISLKLANED 1144
Score = 55.6 bits (128), Expect = 1e-06
Identities = 130/725 (17%), Positives = 297/725 (40%), Gaps = 51/725 (7%)
Query: 152 KEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXX 211
+EK N LQV + E + +EK+ + + +
Sbjct: 505 REKSNLAHSLQVAQQQAEE-LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 563
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLL---EAARFEIS 268
E + +Q+ +++ + E + ++ L + +D+ + E + L EA R E+
Sbjct: 564 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 623
Query: 269 LEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKI 328
L +KL E LA+ ++ + EEK +L+ +
Sbjct: 624 LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 683
Query: 329 ELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
E Q R LE ++A G E + + + + R+ S+++ +Q
Sbjct: 684 VAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 740
Query: 389 LSSETLNQDTDKKINKNEIAKLEMVIQ--SLNKDLVDKEY-------VISEKD--TXXXX 437
LS + ++ + + + E + ++ + K+ + KE+ V +E++ T
Sbjct: 741 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 800
Query: 438 XXXXXXGKDTL----------IAQLQLEHQQ-HMEGPSLIHVGTNTEDVNEIAKVQEQLK 486
K+ L +AQL+ +Q EG +L+ E+A +++Q+
Sbjct: 801 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL--TGELAGLRQQII 858
Query: 487 QELNDEIKDVNVKDLIEKLKSAEEQI-TQLNDEIDAANKNMIKVKSNHKLKLKQMQKTID 545
E ++ + + +KL AE + L ++ A +++ +++ + ++++
Sbjct: 859 A--TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 916
Query: 546 NF-SKVSDSNKEIV-RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMI 603
S++ +E++ RL E LS+++A L++E+ L L + + + + +K
Sbjct: 917 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE-GLLLAESEKQQALSLKESEKTA 975
Query: 604 EMENLAETR--LKAISL-LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E L TR L ISL +E QK D +Q V +++ L++ + E
Sbjct: 976 LSEKLMGTRHSLATISLEMERQKRDAQSRQ---EQDRSTVNALTSELRDLRAQR--EEAA 1030
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
+ H +E + L ++L ++ + E+L ++ LE+ ++ + +L Q +
Sbjct: 1031 AAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE-AQRKLRE 1088
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICR 780
+ + ++ ++ EL + + + + +E ++ ESE K
Sbjct: 1089 SQEGREVQRQEAGELRRSLGEGAKERE----ALRRSNEELRSAVKKAESERISLKLANED 1144
Query: 781 LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
E+ +A++E+ R ++ ++A +L + LQE +++ E + EL ++ +L + + ++
Sbjct: 1145 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE 1204
Query: 841 LLEIE 845
L E++
Sbjct: 1205 LAELQ 1209
Score = 40.3 bits (90), Expect = 0.056
Identities = 70/378 (18%), Positives = 166/378 (43%), Gaps = 23/378 (6%)
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT----QLNDEIDAANKNMIKVK 530
++++A ++ L Q E++ K I K+K+ E ++ +L + +DA+ +K++
Sbjct: 1501 LDQVATLERSL-QATESELRASQEK--ISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1557
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ ++Q++ +SD + L + + L ++VA+ E + G LQL V+ +
Sbjct: 1558 LQRRSLEGELQRSRLG---LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL-TVERLN 1613
Query: 591 GRM--IESDVYKKMIEMENLAETRLKAISLLES---QKFDLVQELHILQQKYDEVEDKLA 645
G + +E ++ L E ++ + L S + L + L + ++++L
Sbjct: 1614 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1673
Query: 646 DISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKED 705
Q S+ + +S L EQ+ L +L L + +QL ++ + +
Sbjct: 1674 AARQALSE---ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1730
Query: 706 IMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD-LYI 764
+N +Q E L ++L + +++L A+ E+S ++ + A + D +
Sbjct: 1731 ALNTVQKLQDERRLLQERLGSLQ-RALAQLEAEKREVERSALRLEKDRVALRRTLDKVER 1789
Query: 765 ENIES--ELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDE 822
E + S + + + RL+ ++ E +R+ QL + + ++++S ++ D
Sbjct: 1790 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1849
Query: 823 LVNRLAVLMDHDRVVEKQ 840
+L + + +R+ Q
Sbjct: 1850 QQQQLELQQEVERLRSAQ 1867
Score = 38.7 bits (86), Expect = 0.17
Identities = 64/350 (18%), Positives = 143/350 (40%), Gaps = 32/350 (9%)
Query: 1196 INQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEH 1255
+ + +L E D L + + L ++ +R + A + L + A+ ++
Sbjct: 1413 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAER--DSATSRARQLQKAVAESEEARR 1470
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ +LS +++ +SV+ S +E T++QV +L+ LQ E LR QEK
Sbjct: 1471 SVDGRLSGVQAELALQEESVRRSERERR---ATLDQVATLERSLQATESELRASQEK--- 1524
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
I++++ +++E +K L + +S + ++S L +++ A
Sbjct: 1525 -ISKMKANETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1579
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAK--VLELT--------HQLELKDSEIYQKTHEYTI 1425
Q + +V D+E K L+LT ++E + + K T
Sbjct: 1580 Q----AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1635
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEI 1482
L Q + + R + + +K + +++ + L R + E ++ ++ +
Sbjct: 1636 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1695
Query: 1483 ERVKLIEELNVKITESVSLNKQVAE-LNKALEEEVAKTNEMQTALENQEI 1531
R + + +L ++ E+ +Q+ E L + E E A N +Q + + +
Sbjct: 1696 LRGE-VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1744
>BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/CAST
family member 2 protein.
Length = 957
Score = 85.0 bits (201), Expect = 2e-15
Identities = 134/652 (20%), Positives = 275/652 (42%), Gaps = 48/652 (7%)
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKS-NHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
L E+++ + E+ L I A + + NH L+ + + ++F+ + + + R
Sbjct: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT-IELTEENFRR 265
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L E ++++ L + ++L + + KK++EM L L + SL
Sbjct: 266 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM--LQSKGLPSKSLE 323
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + + +V + Q + + + + +H Q+ A K L
Sbjct: 324 DDN-----ERTRRMAEAESQVSHLEVILDQKEKENIHLR-EELHRRSQLQPEPAKTKALQ 377
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
VIE L I+DLE ++I N + D ++++++ K K
Sbjct: 378 TVIEMKDTKIASLERNIRDLE---DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKT 434
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
++ + ++ ++++ +E + ++ S K I L+ES+ E R L+ +
Sbjct: 435 KIDQLKQELSKK--ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 492
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI-EHENKELQKKNQIL 858
D L L+EK+ ++ T Q +L L R + K +LE+ E + LQKK + L
Sbjct: 493 DALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM-KDMLEVKERKINVLQKKIENL 551
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLRDLESNLKRITHEH 914
E+ ++ L++++ +L ++ TD A E ++ + + L+ +R E
Sbjct: 552 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
Query: 915 QTLIVQKKKEIEDLEIEFN------TQIESAIRDKK----VLNEKYEKNIEYVTQLEAQL 964
I +KE +DL+ + N T+ ES++ D K L K + LE +
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 965 QEYKNNIENLNM------NVEELNKMNLELID--KHVQKQQTQSPDYTEQYINEINKLNA 1016
++ K L N+E+ ++MN E D K + K+ + D + E+++L
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA-----QFTTKLENME--EEMQRVSK 1069
+LK+ + E ++KI + + + D K+A Q K +N + EE++R
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
Query: 1070 QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE 1119
+ D+ QH EEL + + ++ K + + ++ + E + + IE
Sbjct: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIE 843
Score = 78.6 bits (185), Expect = 2e-13
Identities = 153/741 (20%), Positives = 322/741 (43%), Gaps = 61/741 (8%)
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+S DL +L LQ++ D + +L DI + + IK+ E K+E A
Sbjct: 144 DSTMLDLQAQLKELQRENDLLRKEL-DIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAA 202
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI-MNKLQNYIQENMDLTDKLEKMSAEKISE-LLA 737
+ + KEQ+ + EN + + LQ+ ++ DL L++ S + +E
Sbjct: 203 ----RMSVLKEQM--RVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 256
Query: 738 KINHEEQSKIQTQFGIDAK-IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
++ E ++Q + AK + +E +E + K + +ESI + + L+
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM---LQ 313
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
K L S E + + + V+ L V++D EK+ + H +EL +++Q
Sbjct: 314 SKG--LPSKSLEDDNERTRRMAEAESQVSHLEVILDQK---EKENI---HLREELHRRSQ 365
Query: 857 ILLEENQNLQI-SLSDMQQHYNALVEKANRTDLAESESTKYQTQLR--DLESNLKRI--- 910
+ E + + ++ +M+ A +E+ R E + K L D E +K+I
Sbjct: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
Query: 911 -THEH--QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+H +T I Q K+E+ E E +++ + N +++IE L+ L
Sbjct: 426 KSHSKFMKTKIDQLKQELSKKESEL-LALQTKLETLSNQNSDCKQHIEV---LKESLTAK 481
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ---YINEINKLNALLKQKDEE 1024
+ L V+ L ++ LE + + K+ Q D TE+ EI + +L+ K+ +
Sbjct: 482 EQRAAILQTEVDAL-RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
Query: 1025 IIALNQKINNAQVSYMS---MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
I L +KI N Q +++ + ++ T N + + + + L + ++ E L
Sbjct: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
Query: 1082 QILVREQDDQ--IKEL----KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ RE+DD+ ++E+ KE K L ++N + E S++ + + A+++
Sbjct: 601 KEQ-RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLK 659
Query: 1135 XXXXXXXLKV---QEEEEFIQERSVLQ-----EQSAKLNTELQECYTKIIQLETLNTELT 1186
L++ Q++EE + + L+ E +++N E + +I QL+ +
Sbjct: 660 RDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFAD---QIKQLDKEASYYR 716
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
Q ++++L L+++ E ++ +AEL S + + ++A L ++
Sbjct: 717 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK 776
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEH 1305
+ + Q E R + S ++ ++ + ++ ++ ++ T ++ S Q L +KE H
Sbjct: 777 KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAH 836
Query: 1306 LRNLQEKYADVINQIEILRSE 1326
L NL+ + + +I ++ E
Sbjct: 837 LANLRIERRKQLEEILEMKQE 857
Score = 70.5 bits (165), Expect = 5e-11
Identities = 129/707 (18%), Positives = 283/707 (40%), Gaps = 62/707 (8%)
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
L+++ ++ EENQ+LQ+++ +Q + + + E N +R+
Sbjct: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
Query: 911 THEHQTLIVQK---KKEIEDLEIEFNTQIESA-IRDKKV------LNEKY--EKNIEYVT 958
EH + +K +E++E+ TQ ++ RD+ + L K K++E
Sbjct: 267 QAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDN 326
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQYINEINKLNAL 1017
+ ++ E ++ + +L + +++ K N+ L ++ H + Q P T+ I +
Sbjct: 327 ERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 386
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFT----------TKLENMEEEMQRV 1067
+ + I L +I + + + D E ++ Q TK++ +++E+ +
Sbjct: 387 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 446
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN--IPKTEGMIISSTIEPMSDDA 1125
+LL + E L + I+ LKE+ E I +TE + +E
Sbjct: 447 ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N L E + +L+ + K+N LQ+ ++E L +L
Sbjct: 507 NKKTKQLQDLTEEKGTLA----GEIRDMKDMLEVKERKINV-LQK------KIENLQEQL 555
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA--VDQRGFEIAELWKQHL 1243
D +Q+ LK +++ L T++ N + +A L ++S + +R E E +
Sbjct: 556 RDKD----KQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
Query: 1244 AQREADFQKTEHELRVQLSAFES----KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKL 1299
+ F+K +L+ +++A ++ K L+D + ++ + + ++ SL+ +
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 1300 QDKEEHLRNL--QEKYADVINQIEILRSEIEDE------KVAFXXXXXXXXXXXXXXXXD 1351
+ K+E L Q K A I + E D+ + ++ +
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE- 1410
+ E ++ K +++ I + + K A++LE + E
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
Query: 1411 -LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
+ D+ + + E L + E + + +L ++ + EKE+ LA LR++ +
Sbjct: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLA----EKEAHLANLRIERRKQ 847
Query: 1470 ANHYETMQKESEIERVKLIEELNVKITE-SVSLNKQVAELNKALEEE 1515
M++E+ + + ++ N+ + E S S K+ E AL+ E
Sbjct: 848 LEEILEMKQEALLAAIS-EKDANIALLELSASKKKKTQEEVMALKRE 893
Score = 64.5 bits (150), Expect = 3e-09
Identities = 100/516 (19%), Positives = 219/516 (42%), Gaps = 53/516 (10%)
Query: 476 NEIAKVQEQLK--QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
+E+ +Q +L+ N + K +++ L E L + E++ L E+DA + + +S
Sbjct: 448 SELLALQTKLETLSNQNSDCKQ-HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
K KQ+Q + ++ EI + + L +K+ L+++ NLQ L D D
Sbjct: 507 NKKTKQLQDLTEEKGTLAG---EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 563
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
D K + + +T L + S+K +++ L +Q+ + ++L +I + +
Sbjct: 564 NLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLK--EQRERDDRERLEEIESFRKE 621
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
+ L+E+++AL A E + +LK L L+ D + + L+
Sbjct: 622 -------NKDLKEKVNALQAELTEKESSLIDLKEHASSLASA--GLKRDSK--LKSLEIA 670
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK 773
I++ + KLE ++L N E+ S++ +F +I++ D E K
Sbjct: 671 IEQKKEECSKLE-------AQLKKAHNIEDDSRMNPEFA--DQIKQLDKEASYYRDECGK 721
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
++ + RL E + +E+ + ++K +L S + + H
Sbjct: 722 AQAEVDRLLEILKEVENEKNDKDKKIAELES------------------------LTLRH 757
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+ K++ ++H + +KKN LLEE + + S++D QH + E N + E
Sbjct: 758 MKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-IEELMNALEKTRQEL 816
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
+ +L + +L L ++++K++E++ + +AI +K E +
Sbjct: 817 DATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELS 876
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + ++ K + L +++ + ++L+
Sbjct: 877 ASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLM 912
Score = 60.5 bits (140), Expect = 5e-08
Identities = 140/706 (19%), Positives = 294/706 (41%), Gaps = 79/706 (11%)
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
+V + +L+++ + KELQ++N +L +E L I S + N++ + E
Sbjct: 141 QVRDSTMLDLQAQLKELQRENDLLRKE---LDIKDSKLGSSMNSIKTFWSPELKKERVLR 197
Query: 895 KYQTQLRDLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
K + + R++HE H L +Q ++ + + N ++ ++ + E
Sbjct: 198 KEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIE 257
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
E +L+A+ + L +EE+ ++ +E QKQ + D + + + E+
Sbjct: 258 LTEENFRRLQAEHDRQAKELFLLRKTLEEM-ELRIE-----TQKQTLNARDESIKKLLEM 311
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
+ L + E+ +++ A+ S VS E L Q + ++ EE+ R S QL
Sbjct: 312 LQSKGLPSKSLEDDNERTRRMAEAE----SQVSHLEVILDQKEKENIHLREELHRRS-QL 366
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ LQ ++ E+K+TK+ + E NI E I+ + AN V
Sbjct: 367 QPEPAKTKALQTVI--------EMKDTKIASLERNIRDLE-----DEIQMLK--ANGV-- 409
Query: 1131 XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV 1190
L ++ EE I++ V + S + T++ + L EL+
Sbjct: 410 -----------LNTEDREEEIKQIEVYKSHSKFMKTKIDQ----------LKQELSK--- 445
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI---AELWKQHLAQRE 1247
+ ++ L++KLE L+ +N + + L+ S++ A +QR + + + L ++E
Sbjct: 446 -KESELLALQTKLETLSNQNSDCKQHIEVLKESLT-AKEQRAAILQTEVDALRLRLEEKE 503
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
+ K +L+ + ++ D +E V +++ +LQ +L+DK++ L
Sbjct: 504 SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 563
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
NL+++ ++ L+++ + A L+ + + + + + I
Sbjct: 564 NLKDR-------VKSLQTDSSNTDTALATLEEALSEKERIIER-LKEQRERDDRERLEEI 615
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ +EN LK+ + D + L +DS++ K+ E I +
Sbjct: 616 ESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKL--KSLE--IAI 671
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
Q+ +E + QL + IED + E A ++ + A++Y +++ E +L
Sbjct: 672 EQKKEECSKLEAQLKKAHN-IEDDS-RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 729
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE-NQEIE 1532
+E L E +K++AEL + N+ L+ NQ++E
Sbjct: 730 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
Score = 50.0 bits (114), Expect = 7e-05
Identities = 73/370 (19%), Positives = 157/370 (42%), Gaps = 22/370 (5%)
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE--IAELWKQHLAQREA 1248
V+ E+ L+ ++ L E L T +L + RG E EL +++ + +A
Sbjct: 213 VSHEENQHLQLTIQALQDE----LRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA 268
Query: 1249 DFQKTEHEL---RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK-LQDKEE 1304
+ + EL R L E + E ++ ++ E K++ M Q L +K L+D E
Sbjct: 269 EHDRQAKELFLLRKTLEEMELRIETQKQTL-NARDESIKKLLEMLQSKGLPSKSLEDDNE 327
Query: 1305 HLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX--XXXXDLRT--ENQSYK 1360
R + E + V + +E++ + E E + L+T E + K
Sbjct: 328 RTRRMAEAESQV-SHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 386
Query: 1361 QMQ-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
E++I ++ +E LK + ++ ++ + +++ E+ +K
Sbjct: 387 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 446
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
E + L + + N ++ + +++ KE AIL+ ++ +A +KE
Sbjct: 447 ESEL-LALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV--DALRLRLEEKE 503
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
S + K ++L E +L ++ ++ LE + K N +Q +EN + ++ + +
Sbjct: 504 SFLN--KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ 561
Query: 1540 ITNLQNMVRA 1549
+TNL++ V++
Sbjct: 562 LTNLKDRVKS 571
Score = 44.4 bits (100), Expect = 0.003
Identities = 102/577 (17%), Positives = 220/577 (38%), Gaps = 51/577 (8%)
Query: 1014 LNALLK--QKDEEIIALNQKINNAQV-SYMSMVSDYESKLAQFTTKLENMEEEMQRVSK- 1069
L A LK Q++ +++ I ++++ S M+ + + S + L E V K
Sbjct: 150 LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE 209
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
Q+ S + N+ LQ+ ++ D+++ ++ + TIE ++ +
Sbjct: 210 QMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF--TIELTEENFRRLQ 267
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ---ERSVLQEQSAKLNTELQECYTKIIQLETL--NTE 1184
L+ EE ++ ++ L + + L+ +K + ++L + E
Sbjct: 268 AEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNE 327
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE-IAELWKQHL 1243
T + Q++ L+ L+Q EN +L + + + + E+ +
Sbjct: 328 RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKI 387
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE 1303
A E + + E E+++ + E + ++ +++ ++ L+ +L KE
Sbjct: 388 ASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 447
Query: 1304 EHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXX-DLRTEN-QSYKQ 1361
L LQ K + NQ + IE K + LR E +S+
Sbjct: 448 SELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN 507
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
+ + + ++ EE L ++N + K+ L QL KD +
Sbjct: 508 KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ------ 561
Query: 1422 EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE 1481
LT D ++++ + ++ LA L + E E ++++ E
Sbjct: 562 -----LTNLKDRVKSLQTD-----------SSNTDTALATLEEALSEKERIIERLKEQRE 605
Query: 1482 IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT 1541
+ + +EE+ S K+ NK L+E+V N +Q L +E ++ L + +
Sbjct: 606 RDDRERLEEIE-------SFRKE----NKDLKEKV---NALQAELTEKESSLIDLKEHAS 651
Query: 1542 NLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+L + SK+ K + A + K+ +L+ + K
Sbjct: 652 SLASAGLKRDSKL-KSLEIAIEQKKEECSKLEAQLKK 687
Score = 40.7 bits (91), Expect = 0.042
Identities = 57/281 (20%), Positives = 115/281 (40%), Gaps = 18/281 (6%)
Query: 72 KEHRKATAELLG-RPFVPGISESLANTLKQKEILMEKI--KQYKELSKRSSTTIVRXXXX 128
+E K +ELL + + +S ++ + E+L E + K+ + ++ +R
Sbjct: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 500
Query: 129 XXXXXXXXXXXQLGDVTH----LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD- 183
QL D+T L+ I++ + L V + K+ +++ I +LQE++ +KD
Sbjct: 501 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDK 560
Query: 184 QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDI 243
Q+ K++ + E+ + ++ E E +D+++R L++I
Sbjct: 561 QLTNLKDRVKS--LQTDSSNTDTALATLEEALSEKERIIERL--KEQRERDDRER-LEEI 615
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPS 303
ES L+E L+A E++ + S L E L +S+E +
Sbjct: 616 ESFRKENKDLKEKVNALQA---ELTEKESSLIDLKEHASSLASAGLKRDSKL--KSLEIA 670
Query: 304 CEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
E+K E K ++ + + QI+Q +KE
Sbjct: 671 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE 711
>BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein.
Length = 957
Score = 85.0 bits (201), Expect = 2e-15
Identities = 134/652 (20%), Positives = 275/652 (42%), Gaps = 48/652 (7%)
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKS-NHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
L E+++ + E+ L I A + + NH L+ + + ++F+ + + + R
Sbjct: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT-IELTEENFRR 265
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L E ++++ L + ++L + + KK++EM L L + SL
Sbjct: 266 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM--LQSKGLPSKSLE 323
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + + +V + Q + + + + +H Q+ A K L
Sbjct: 324 DDN-----ERTRRMAEAESQVSHLEVILDQKEKENIHLR-EELHRRSQLQPEPAKTKALQ 377
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
VIE L I+DLE ++I N + D ++++++ K K
Sbjct: 378 TVIEMKDTKIASLERNIRDLE---DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKT 434
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
++ + ++ ++++ +E + ++ S K I L+ES+ E R L+ +
Sbjct: 435 KIDQLKQELSKK--ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 492
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI-EHENKELQKKNQIL 858
D L L+EK+ ++ T Q +L L R + K +LE+ E + LQKK + L
Sbjct: 493 DALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM-KDMLEVKERKINVLQKKIENL 551
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLRDLESNLKRITHEH 914
E+ ++ L++++ +L ++ TD A E ++ + + L+ +R E
Sbjct: 552 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
Query: 915 QTLIVQKKKEIEDLEIEFN------TQIESAIRDKK----VLNEKYEKNIEYVTQLEAQL 964
I +KE +DL+ + N T+ ES++ D K L K + LE +
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 965 QEYKNNIENLNM------NVEELNKMNLELID--KHVQKQQTQSPDYTEQYINEINKLNA 1016
++ K L N+E+ ++MN E D K + K+ + D + E+++L
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA-----QFTTKLENME--EEMQRVSK 1069
+LK+ + E ++KI + + + D K+A Q K +N + EE++R
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
Query: 1070 QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE 1119
+ D+ QH EEL + + ++ K + + ++ + E + + IE
Sbjct: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIE 843
Score = 78.6 bits (185), Expect = 2e-13
Identities = 153/741 (20%), Positives = 322/741 (43%), Gaps = 61/741 (8%)
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+S DL +L LQ++ D + +L DI + + IK+ E K+E A
Sbjct: 144 DSTMLDLQAQLKELQRENDLLRKEL-DIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAA 202
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI-MNKLQNYIQENMDLTDKLEKMSAEKISE-LLA 737
+ + KEQ+ + EN + + LQ+ ++ DL L++ S + +E
Sbjct: 203 ----RMSVLKEQM--RVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 256
Query: 738 KINHEEQSKIQTQFGIDAK-IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
++ E ++Q + AK + +E +E + K + +ESI + + L+
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM---LQ 313
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
K L S E + + + V+ L V++D EK+ + H +EL +++Q
Sbjct: 314 SKG--LPSKSLEDDNERTRRMAEAESQVSHLEVILDQK---EKENI---HLREELHRRSQ 365
Query: 857 ILLEENQNLQI-SLSDMQQHYNALVEKANRTDLAESESTKYQTQLR--DLESNLKRI--- 910
+ E + + ++ +M+ A +E+ R E + K L D E +K+I
Sbjct: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
Query: 911 -THEH--QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+H +T I Q K+E+ E E +++ + N +++IE L+ L
Sbjct: 426 KSHSKFMKTKIDQLKQELSKKESEL-LALQTKLETLSNQNSDCKQHIEV---LKESLTAK 481
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ---YINEINKLNALLKQKDEE 1024
+ L V+ L ++ LE + + K+ Q D TE+ EI + +L+ K+ +
Sbjct: 482 EQRAAILQTEVDAL-RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
Query: 1025 IIALNQKINNAQVSYMS---MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
I L +KI N Q +++ + ++ T N + + + + L + ++ E L
Sbjct: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
Query: 1082 QILVREQDDQ--IKEL----KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ RE+DD+ ++E+ KE K L ++N + E S++ + + A+++
Sbjct: 601 KEQ-RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLK 659
Query: 1135 XXXXXXXLKV---QEEEEFIQERSVLQ-----EQSAKLNTELQECYTKIIQLETLNTELT 1186
L++ Q++EE + + L+ E +++N E + +I QL+ +
Sbjct: 660 RDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFAD---QIKQLDKEASYYR 716
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
Q ++++L L+++ E ++ +AEL S + + ++A L ++
Sbjct: 717 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK 776
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEH 1305
+ + Q E R + S ++ ++ + ++ ++ ++ T ++ S Q L +KE H
Sbjct: 777 KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAH 836
Query: 1306 LRNLQEKYADVINQIEILRSE 1326
L NL+ + + +I ++ E
Sbjct: 837 LANLRIERRKQLEEILEMKQE 857
Score = 70.5 bits (165), Expect = 5e-11
Identities = 129/707 (18%), Positives = 283/707 (40%), Gaps = 62/707 (8%)
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
L+++ ++ EENQ+LQ+++ +Q + + + E N +R+
Sbjct: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
Query: 911 THEHQTLIVQK---KKEIEDLEIEFNTQIESA-IRDKKV------LNEKY--EKNIEYVT 958
EH + +K +E++E+ TQ ++ RD+ + L K K++E
Sbjct: 267 QAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDN 326
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQYINEINKLNAL 1017
+ ++ E ++ + +L + +++ K N+ L ++ H + Q P T+ I +
Sbjct: 327 ERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 386
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFT----------TKLENMEEEMQRV 1067
+ + I L +I + + + D E ++ Q TK++ +++E+ +
Sbjct: 387 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 446
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN--IPKTEGMIISSTIEPMSDDA 1125
+LL + E L + I+ LKE+ E I +TE + +E
Sbjct: 447 ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N L E + +L+ + K+N LQ+ ++E L +L
Sbjct: 507 NKKTKQLQDLTEEKGTLA----GEIRDMKDMLEVKERKINV-LQK------KIENLQEQL 555
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA--VDQRGFEIAELWKQHL 1243
D +Q+ LK +++ L T++ N + +A L ++S + +R E E +
Sbjct: 556 RDKD----KQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
Query: 1244 AQREADFQKTEHELRVQLSAFES----KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKL 1299
+ F+K +L+ +++A ++ K L+D + ++ + + ++ SL+ +
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 1300 QDKEEHLRNL--QEKYADVINQIEILRSEIEDE------KVAFXXXXXXXXXXXXXXXXD 1351
+ K+E L Q K A I + E D+ + ++ +
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE- 1410
+ E ++ K +++ I + + K A++LE + E
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
Query: 1411 -LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
+ D+ + + E L + E + + +L ++ + EKE+ LA LR++ +
Sbjct: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLA----EKEAHLANLRIERRKQ 847
Query: 1470 ANHYETMQKESEIERVKLIEELNVKITE-SVSLNKQVAELNKALEEE 1515
M++E+ + + ++ N+ + E S S K+ E AL+ E
Sbjct: 848 LEEILEMKQEALLAAIS-EKDANIALLELSASKKKKTQEEVMALKRE 893
Score = 64.5 bits (150), Expect = 3e-09
Identities = 100/516 (19%), Positives = 219/516 (42%), Gaps = 53/516 (10%)
Query: 476 NEIAKVQEQLK--QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
+E+ +Q +L+ N + K +++ L E L + E++ L E+DA + + +S
Sbjct: 448 SELLALQTKLETLSNQNSDCKQ-HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
K KQ+Q + ++ EI + + L +K+ L+++ NLQ L D D
Sbjct: 507 NKKTKQLQDLTEEKGTLAG---EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 563
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
D K + + +T L + S+K +++ L +Q+ + ++L +I + +
Sbjct: 564 NLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLK--EQRERDDRERLEEIESFRKE 621
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
+ L+E+++AL A E + +LK L L+ D + + L+
Sbjct: 622 -------NKDLKEKVNALQAELTEKESSLIDLKEHASSLASA--GLKRDSK--LKSLEIA 670
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK 773
I++ + KLE ++L N E+ S++ +F +I++ D E K
Sbjct: 671 IEQKKEECSKLE-------AQLKKAHNIEDDSRMNPEFA--DQIKQLDKEASYYRDECGK 721
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
++ + RL E + +E+ + ++K +L S + + H
Sbjct: 722 AQAEVDRLLEILKEVENEKNDKDKKIAELES------------------------LTLRH 757
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+ K++ ++H + +KKN LLEE + + S++D QH + E N + E
Sbjct: 758 MKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-IEELMNALEKTRQEL 816
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
+ +L + +L L ++++K++E++ + +AI +K E +
Sbjct: 817 DATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELS 876
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + ++ K + L +++ + ++L+
Sbjct: 877 ASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLM 912
Score = 60.5 bits (140), Expect = 5e-08
Identities = 140/706 (19%), Positives = 294/706 (41%), Gaps = 79/706 (11%)
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
+V + +L+++ + KELQ++N +L +E L I S + N++ + E
Sbjct: 141 QVRDSTMLDLQAQLKELQRENDLLRKE---LDIKDSKLGSSMNSIKTFWSPELKKERVLR 197
Query: 895 KYQTQLRDLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
K + + R++HE H L +Q ++ + + N ++ ++ + E
Sbjct: 198 KEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIE 257
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
E +L+A+ + L +EE+ ++ +E QKQ + D + + + E+
Sbjct: 258 LTEENFRRLQAEHDRQAKELFLLRKTLEEM-ELRIE-----TQKQTLNARDESIKKLLEM 311
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
+ L + E+ +++ A+ S VS E L Q + ++ EE+ R S QL
Sbjct: 312 LQSKGLPSKSLEDDNERTRRMAEAE----SQVSHLEVILDQKEKENIHLREELHRRS-QL 366
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ LQ ++ E+K+TK+ + E NI E I+ + AN V
Sbjct: 367 QPEPAKTKALQTVI--------EMKDTKIASLERNIRDLE-----DEIQMLK--ANGV-- 409
Query: 1131 XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV 1190
L ++ EE I++ V + S + T++ + L EL+
Sbjct: 410 -----------LNTEDREEEIKQIEVYKSHSKFMKTKIDQ----------LKQELSK--- 445
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI---AELWKQHLAQRE 1247
+ ++ L++KLE L+ +N + + L+ S++ A +QR + + + L ++E
Sbjct: 446 -KESELLALQTKLETLSNQNSDCKQHIEVLKESLT-AKEQRAAILQTEVDALRLRLEEKE 503
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
+ K +L+ + ++ D +E V +++ +LQ +L+DK++ L
Sbjct: 504 SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 563
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
NL+++ ++ L+++ + A L+ + + + + + I
Sbjct: 564 NLKDR-------VKSLQTDSSNTDTALATLEEALSEKERIIER-LKEQRERDDRERLEEI 615
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ +EN LK+ + D + L +DS++ K+ E I +
Sbjct: 616 ESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKL--KSLE--IAI 671
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
Q+ +E + QL + IED + E A ++ + A++Y +++ E +L
Sbjct: 672 EQKKEECSKLEAQLKKAHN-IEDDS-RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 729
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE-NQEIE 1532
+E L E +K++AEL + N+ L+ NQ++E
Sbjct: 730 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
Score = 50.0 bits (114), Expect = 7e-05
Identities = 73/370 (19%), Positives = 157/370 (42%), Gaps = 22/370 (5%)
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE--IAELWKQHLAQREA 1248
V+ E+ L+ ++ L E L T +L + RG E EL +++ + +A
Sbjct: 213 VSHEENQHLQLTIQALQDE----LRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA 268
Query: 1249 DFQKTEHEL---RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK-LQDKEE 1304
+ + EL R L E + E ++ ++ E K++ M Q L +K L+D E
Sbjct: 269 EHDRQAKELFLLRKTLEEMELRIETQKQTL-NARDESIKKLLEMLQSKGLPSKSLEDDNE 327
Query: 1305 HLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX--XXXXDLRT--ENQSYK 1360
R + E + V + +E++ + E E + L+T E + K
Sbjct: 328 RTRRMAEAESQV-SHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 386
Query: 1361 QMQ-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
E++I ++ +E LK + ++ ++ + +++ E+ +K
Sbjct: 387 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 446
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
E + L + + N ++ + +++ KE AIL+ ++ +A +KE
Sbjct: 447 ESEL-LALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV--DALRLRLEEKE 503
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
S + K ++L E +L ++ ++ LE + K N +Q +EN + ++ + +
Sbjct: 504 SFLN--KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ 561
Query: 1540 ITNLQNMVRA 1549
+TNL++ V++
Sbjct: 562 LTNLKDRVKS 571
Score = 44.4 bits (100), Expect = 0.003
Identities = 102/577 (17%), Positives = 220/577 (38%), Gaps = 51/577 (8%)
Query: 1014 LNALLK--QKDEEIIALNQKINNAQV-SYMSMVSDYESKLAQFTTKLENMEEEMQRVSK- 1069
L A LK Q++ +++ I ++++ S M+ + + S + L E V K
Sbjct: 150 LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE 209
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
Q+ S + N+ LQ+ ++ D+++ ++ + TIE ++ +
Sbjct: 210 QMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF--TIELTEENFRRLQ 267
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ---ERSVLQEQSAKLNTELQECYTKIIQLETL--NTE 1184
L+ EE ++ ++ L + + L+ +K + ++L + E
Sbjct: 268 AEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNE 327
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE-IAELWKQHL 1243
T + Q++ L+ L+Q EN +L + + + + E+ +
Sbjct: 328 RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKI 387
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE 1303
A E + + E E+++ + E + ++ +++ ++ L+ +L KE
Sbjct: 388 ASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 447
Query: 1304 EHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXX-DLRTEN-QSYKQ 1361
L LQ K + NQ + IE K + LR E +S+
Sbjct: 448 SELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN 507
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
+ + + ++ EE L ++N + K+ L QL KD +
Sbjct: 508 KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ------ 561
Query: 1422 EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE 1481
LT D ++++ + ++ LA L + E E ++++ E
Sbjct: 562 -----LTNLKDRVKSLQTD-----------SSNTDTALATLEEALSEKERIIERLKEQRE 605
Query: 1482 IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT 1541
+ + +EE+ S K+ NK L+E+V N +Q L +E ++ L + +
Sbjct: 606 RDDRERLEEIE-------SFRKE----NKDLKEKV---NALQAELTEKESSLIDLKEHAS 651
Query: 1542 NLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+L + SK+ K + A + K+ +L+ + K
Sbjct: 652 SLASAGLKRDSKL-KSLEIAIEQKKEECSKLEAQLKK 687
Score = 40.7 bits (91), Expect = 0.042
Identities = 57/281 (20%), Positives = 115/281 (40%), Gaps = 18/281 (6%)
Query: 72 KEHRKATAELLG-RPFVPGISESLANTLKQKEILMEKI--KQYKELSKRSSTTIVRXXXX 128
+E K +ELL + + +S ++ + E+L E + K+ + ++ +R
Sbjct: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 500
Query: 129 XXXXXXXXXXXQLGDVTH----LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD- 183
QL D+T L+ I++ + L V + K+ +++ I +LQE++ +KD
Sbjct: 501 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDK 560
Query: 184 QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDI 243
Q+ K++ + E+ + ++ E E +D+++R L++I
Sbjct: 561 QLTNLKDRVKS--LQTDSSNTDTALATLEEALSEKERIIERL--KEQRERDDRER-LEEI 615
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPS 303
ES L+E L+A E++ + S L E L +S+E +
Sbjct: 616 ESFRKENKDLKEKVNALQA---ELTEKESSLIDLKEHASSLASAGLKRDSKL--KSLEIA 670
Query: 304 CEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
E+K E K ++ + + QI+Q +KE
Sbjct: 671 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE 711
>AB035898-1|BAB03309.1| 1388|Homo sapiens kinesin-like protein 2
protein.
Length = 1388
Score = 85.0 bits (201), Expect = 2e-15
Identities = 160/785 (20%), Positives = 352/785 (44%), Gaps = 80/785 (10%)
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKLK+ Q+ Q+ E++ + + + K + + +++ + + K + + + ++ T+
Sbjct: 582 EKLKA---QLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATK 638
Query: 563 ELHHLSQKVAELEE-EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
Q+V++L + L++ + ++ V K EM + + S+L++
Sbjct: 639 ACKR--QEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDN 696
Query: 622 QKFDLVQELHILQQKYDEVEDKLADI----SQLQSDQVCSEIKSVHLEEQIDALSASKKE 677
+ + +Q ++ + ++L + S LQ+ E K++ L++ +D L +
Sbjct: 697 DILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQ 756
Query: 678 LALVIENLKLD----KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKL----EKMSA 729
+ + + ++D +E+L + LE ++ K E DL L +++S+
Sbjct: 757 MQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSS 816
Query: 730 EKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
K+ K N E++ ++ + ++Q +L +EN E L +S+ C + + E
Sbjct: 817 VKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLEN-EKLL---ESKACLQDSYDNLQE 872
Query: 790 DRRYSLERKADQLGSYLQEKQKAYS------EYTIQEDELVNRLAVLMDHDRV-VEKQLL 842
++ +++ + L ++ +E + S E E E N+L++ + D+ K++L
Sbjct: 873 IMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEIL 932
Query: 843 EI-EHENKELQK---KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
++ E +E QK K + + + Q L+ SL ++ ++L EK+ +D +
Sbjct: 933 KVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSL-EKSRDSD--KKVVADLMN 989
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI---E 955
Q+++L +++ T TL K+E++D+ ++N+ + + +VL +K E +I +
Sbjct: 990 QIQELRTSVCEKTETIDTL----KQELKDINCKYNSALVDR-EESRVLIKKQEVDILDLK 1044
Query: 956 YVTQLEAQLQEYKNNI--ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT--EQYINEI 1011
+L ++ + ++ E+L E+LN + E KH Q+ + T E I E+
Sbjct: 1045 ETLRLRILSEDIERDMLCEDLAHATEQLNMLT-EASKKHSGLLQSAQEELTKKEALIQEL 1103
Query: 1012 -NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA--QFTTKL----ENMEEEM 1064
+KLN ++ +++ N K+ + S D +S F T L E E+E+
Sbjct: 1104 QHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEI 1163
Query: 1065 Q--RVSKQLLDS--KQHNEELQILVRE---QDDQIKELKETKLTFEMNIPKTEGMIISST 1117
+ R SK L+ + NE+ ++ E +Q++E++ +L + I K ++
Sbjct: 1164 EDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKN--WLLQGQ 1221
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER---SVLQEQSAKLNTELQEC--- 1171
++ + N D LK E+EE I+ER S + E+ K+ +L+E
Sbjct: 1222 LDDIKRQKENSDQNHPDNQQ----LK-NEQEESIKERLAKSKIVEEMLKMKADLEEVQSA 1276
Query: 1172 -YTKIIQLETLNTELTGHDVVNQ---EQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
Y K ++ + E+ + ++ QL+SKLE++ E + + LR +
Sbjct: 1277 LYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECL 1336
Query: 1228 VDQRG 1232
++ G
Sbjct: 1337 AEENG 1341
Score = 79.4 bits (187), Expect = 1e-13
Identities = 186/931 (19%), Positives = 378/931 (40%), Gaps = 74/931 (7%)
Query: 682 IENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMD--LTDKLEKMSAE---KISELL 736
+E+L L KE+ + K + +ED + +L+ +E+ L ++ +++ +E +I L
Sbjct: 442 LEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLR 501
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDL-YIENIESELSKYKSRICRLEES---IAVMED-- 790
+I H + + + R L +E ++ I +LE++ I+ ME
Sbjct: 502 EQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSD 561
Query: 791 -RRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
+ KA + +K ++ + EL N + + K+ LE+E E +
Sbjct: 562 KNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQ 621
Query: 850 ELQKKNQILLEENQNLQISLSDMQQHYNALVE-KANRTDLAESESTKYQTQLRDLESNLK 908
LQK N L EN L+ + + +Q + L + A + + + YQ R + L
Sbjct: 622 SLQKANLNL--ENL-LEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPK-LS 677
Query: 909 RITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYK 968
+L Q +++ + E + + ++E+ E ++ L+A+L E +
Sbjct: 678 PEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEE 737
Query: 969 NNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA- 1027
+ L +V++L + ++ + ++ D+T+Q +++LN L KQ E
Sbjct: 738 HKNLKLQQHVDKLEHHSTQMQELF----SSERIDWTKQQEELLSQLNVLEKQLQETQTKN 793
Query: 1028 --LNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK-------QLLDSKQHN 1078
L ++++ +V S + S ++++ N E+E ++S+ QL + + N
Sbjct: 794 DFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLEN 853
Query: 1079 EELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXX 1138
E+L D L+E + FE++ E + D NN+
Sbjct: 854 EKLLESKACLQDSYDNLQEI-MKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKER 912
Query: 1139 XXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQ 1198
L +Q EE+ +E S+K ++ E + Q ET E Q
Sbjct: 913 NNKLSLQFEED--------KENSSKEILKVLEAVRQEKQKETAKCE-------------Q 951
Query: 1199 LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE--HE 1256
+K+++L ++LL+T ++ SS+ + D +A+L Q R + +KTE
Sbjct: 952 QMAKVQKLE---ESLLAT-EKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDT 1007
Query: 1257 LRVQLSAFESKYEQ-LLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
L+ +L KY L+D +S + ++ ++ +L+ ++ ++ L E A
Sbjct: 1008 LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAH 1067
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
Q+ +L +E + +L+ + K+ EQ N +
Sbjct: 1068 ATEQLNML-TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMR 1126
Query: 1376 QLKK--SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
QL+ S AK+LE T + E++D + + E+ +T + E
Sbjct: 1127 QLEHVMDSAAEDPQSPKTPPHFQTHLAKLLE-TQEQEIEDGRASKTSLEHLVTKLNEDRE 1185
Query: 1434 FENVR-QQLVEYEKRIEDLTYEKES--ELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
+N ++ E + +E+L E + E L ++ + ++ + +L E
Sbjct: 1186 VKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNE 1245
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
I E ++ +K V E+ K A E+Q+AL N+E+E + + DE+ Q +
Sbjct: 1246 QEESIKERLAKSKIVEEMLKMK----ADLEEVQSALYNKEMECLRMTDEVERTQTL---E 1298
Query: 1551 SSKIQKHVSFASDTKQGRDEQLDNTMNKELL 1581
S Q+ S ++ +E+ + E+L
Sbjct: 1299 SKAFQEKEQLRSKLEEMYEERERTSQEMEML 1329
Score = 77.8 bits (183), Expect = 3e-13
Identities = 167/885 (18%), Positives = 354/885 (40%), Gaps = 84/885 (9%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKL---QNYIQENMDLTDKLEKMSAEKI 732
K A+V E+ + + QL +K L+ ++ + ++++ + T+ +E +
Sbjct: 364 KNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAML 423
Query: 733 SELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRR 792
K E++S I+ ++ +++ +I++ + + + +I RLE+ E R
Sbjct: 424 --FFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK--LHKESRG 479
Query: 793 YSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ 852
L + D+L S L+ + + E I+ V + A + +H E + L + K Q
Sbjct: 480 GFLPEEQDRLLSELRNEIQTLREQ-IEHHPRVAKYA-MENHSLREENRRLRLLEPVKRAQ 537
Query: 853 KKNQILLEENQNLQISLSDMQQ---HYNALVEKANRTDLAESESTKYQTQLRDLESNLKR 909
+ + + + + +S M++ + KA + + + K + QL +++ L
Sbjct: 538 EMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN 597
Query: 910 ITHEHQTLIVQKKKEIEDLEIEF------NTQIESAIRDKKV--------LNEKYEKNIE 955
E++ +K +LE E N +E+ + K LN+ + + ++
Sbjct: 598 SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLK 657
Query: 956 YVTQLEAQLQEYKNNIENLNMNVEELNKM---NLELIDKHVQKQQTQSPDYTEQYINEIN 1012
+T Q + + L+ + + N ++D + + P+ EQ I+
Sbjct: 658 IITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVP-PEMNEQAFEAIS 716
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV-SKQL 1071
+ L+ E++ AL K++ + + KL Q KLE+ +MQ + S +
Sbjct: 717 EE---LRTVQEQMSALQAKLDEEEHKNL--------KLQQHVDKLEHHSTQMQELFSSER 765
Query: 1072 LDSKQHNEEL--QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+D + EEL Q+ V E K+L+ET+ T+ + S + + ++ D
Sbjct: 766 IDWTKQQEELLSQLNVLE-----KQLQETQ---------TKNDFLKSEVHDLRVVLHSAD 811
Query: 1130 XXXXXXXXXXXXLKVQEEEEF--IQERSV---LQEQSAKLNTE--------LQECYTKII 1176
K +E+EF + ER + LQ + +L E LQ+ Y +
Sbjct: 812 KELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQ 871
Query: 1177 QLETLNTELTGHDVVNQEQINQ-LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
++ + ++ N ++ N+ LKS L L + +L + EI
Sbjct: 872 EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEI 931
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKY--EQLLDSVQSSTQEETNKIVT--MEQ 1291
++ + +++ + K E ++ ES E+++ S++ S ++ K+V M Q
Sbjct: 932 LKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKS-RDSDKKVVADLMNQ 990
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L+ + +K E + L+++ D+ + + E+ +V
Sbjct: 991 IQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLR 1050
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
+ +E+ + M + + + E+ L ++S + EA + EL H+L
Sbjct: 1051 ILSEDIE-RDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQ 1109
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENAN 1471
K E+ QK +EY + Q E+V E + + ++ LA L +
Sbjct: 1110 KKEEVEQKKNEYNFKMRQ----LEHVMDSAAE-DPQSPKTPPHFQTHLAKLLETQEQEIE 1164
Query: 1472 HYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL-NKALEEE 1515
+ E KL E+ VK E + + +Q+ E+ N LE +
Sbjct: 1165 DGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQ 1209
Score = 77.0 bits (181), Expect = 5e-13
Identities = 161/923 (17%), Positives = 393/923 (42%), Gaps = 62/923 (6%)
Query: 445 KDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK 504
K T + L L+ ++ ++ +I V + + + K+ ++ + E +D + +L +
Sbjct: 438 KVTQLEDLTLKKEKFIQSNKMI-VKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNE 496
Query: 505 LKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL 564
+++ EQI A +N + N +L+L + K + + E + E+
Sbjct: 497 IQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLE--KAFSEI 554
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKF 624
+ + + Q + + +++ + + E+ N + + L ++
Sbjct: 555 SGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQL 614
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
+L EL LQ+ +E+ L + +V S++ +H E + ++ K L
Sbjct: 615 ELESELQSLQKANLNLENLLEATKACKRQEV-SQLNKIHAET-LKIITTPTKAYQLHSRP 672
Query: 685 L-KLDKEQLYGTIKDLENDKEDIMNK--LQNYIQENMD------LTDKLEKMSAEKISEL 735
+ KL E G+ L I++ L + M+ ++++L + E++S L
Sbjct: 673 VPKLSPEM--GSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQ-EQMSAL 729
Query: 736 LAKINHEEQSKIQTQFGIDA----KIQERDLYI-ENIE--SELSKYKSRICRLEESIAVM 788
AK++ EE ++ Q +D Q ++L+ E I+ + + S++ LE+ +
Sbjct: 730 QAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQET 789
Query: 789 EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
+ + L+ + L L K S ++ + +++ E+ + ++ +
Sbjct: 790 QTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQE--KEFNKLSERHM-HVQLQL 846
Query: 849 KELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT-DLAESESTKYQTQLRDLESNL 907
L+ +N+ LLE LQ S ++Q+ +++ +R + E+ ++ L +L L
Sbjct: 847 DNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELL 906
Query: 908 KRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + L +Q +++ E+ E +E+ ++K+ K E+ + V +LE L
Sbjct: 907 EAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLAT 966
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQK------QQTQSPDYTEQYINEIN-KLNALLKQ 1020
+ I +L + + K+ +L+++ +Q+ ++T++ D +Q + +IN K N+ L
Sbjct: 967 EKVISSLEKSRDSDKKVVADLMNQ-IQELRTSVCEKTETIDTLKQELKDINCKYNSALVD 1025
Query: 1021 KDEEIIALNQK----INNAQVSYMSMVS-DYE-----SKLAQFTTKLENMEEEMQRVSKQ 1070
++E + + ++ ++ + + ++S D E LA T +L + E ++ S
Sbjct: 1026 REESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGL 1085
Query: 1071 LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
L +++ + + L++E ++ + KE ++ + N + + ++ ++D +
Sbjct: 1086 LQSAQEELTKKEALIQELQHKLNQKKE-EVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKT 1144
Query: 1131 XXXXXXXXXXXLKVQEEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGH 1188
L+ QE+E + ++ L+ KLN + + +I++++ E+
Sbjct: 1145 PPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENL 1204
Query: 1189 DVVNQEQINQ---LKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQ 1245
+ +Q+ I + L+ +L+ + + +N + + Q E E K+ LA+
Sbjct: 1205 RLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQ--------QLKNEQEESIKERLAK 1256
Query: 1246 REA--DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE 1303
+ + K + +L SA +K + L + +T + ++ L++KL++
Sbjct: 1257 SKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMY 1316
Query: 1304 EHLRNLQEKYADVINQIEILRSE 1326
E ++ + Q+E L E
Sbjct: 1317 EERERTSQEMEMLRKQVECLAEE 1339
Score = 49.2 bits (112), Expect = 1e-04
Identities = 119/660 (18%), Positives = 270/660 (40%), Gaps = 52/660 (7%)
Query: 219 TKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQEL 278
T+MQE F + +W +++ LL + + ++ + N L++ ++ + +EL
Sbjct: 755 TQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKEL 814
Query: 279 EQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQI 338
K + E + +E L++ N+ +K LLE C
Sbjct: 815 SSVKLEYSSF--------KTNQEKEFNKLSERHMHVQLQLDNLRLENEK--LLESKACLQ 864
Query: 339 RQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSE-TLNQD 397
+ E + S+ + + K+ L KS N ++ + +++ +L +
Sbjct: 865 DSYDNLQEIMKFEIDQLSRNLQNFKKENETL---KSDLNNLMELLEAEKERNNKLSLQFE 921
Query: 398 TDKKINKNEIAK-LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEH 456
DK+ + EI K LE V Q K+ E +++ + +I+ LE
Sbjct: 922 EDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLAT----EKVIS--SLEK 975
Query: 457 QQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN 516
+ + + + +++ + + L E+KD+N K + E ++
Sbjct: 976 SRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKK 1035
Query: 517 DEIDAAN-KNMIKVK-----SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEEL-HHLSQ 569
E+D + K ++++ + + + + + +++++K+ L + L++
Sbjct: 1036 QEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTK 1095
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K A ++E + L + + + ++ KM ++E++ ++ + ++
Sbjct: 1096 KEALIQELQHKLNQKKEEVEQKK---NEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHL 1152
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK 689
+L+ + E+ED A S+ + + +++ + + L KE +ENL+L+
Sbjct: 1153 AKLLETQEQEIEDGRA--SKTSLEHLVTKLNEDREVKNAEIL--RMKEQLREMENLRLES 1208
Query: 690 EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQT 749
+QL L+ +DI + +N Q + D +L+ E I E LAK ++
Sbjct: 1209 QQLIEKNWLLQGQLDDIKRQKENSDQNHPD-NQQLKNEQEESIKERLAK-----SKIVEE 1262
Query: 750 QFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEK 809
+ A ++E + N E E + + E +E + + ++ +QL S L+E
Sbjct: 1263 MLKMKADLEEVQSALYNKEMECLRMTDEV----ERTQTLESKAF---QEKEQLRSKLEEM 1315
Query: 810 QKAYSEYTIQEDELVNRLAVLM--DHDRVVEKQLLEIEHEN-KELQKKNQILLEENQNLQ 866
+ E T QE E++ + + ++ ++V Q L + + L+K+N L EE + L+
Sbjct: 1316 YEE-RERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLR 1374
>AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein.
Length = 970
Score = 85.0 bits (201), Expect = 2e-15
Identities = 134/652 (20%), Positives = 275/652 (42%), Gaps = 48/652 (7%)
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKS-NHKLKLKQMQKTIDNFSKVSDSNKEIVR 559
L E+++ + E+ L I A + + NH L+ + + ++F+ + + + R
Sbjct: 220 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT-IELTEENFRR 278
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLL 619
L E ++++ L + ++L + + KK++EM L L + SL
Sbjct: 279 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM--LQSKGLPSKSLE 336
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+ + + + +V + Q + + + + +H Q+ A K L
Sbjct: 337 DDN-----ERTRRMAEAESQVSHLEVILDQKEKENIHLR-EELHRRSQLQPEPAKTKALQ 390
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKI 739
VIE L I+DLE ++I N + D ++++++ K K
Sbjct: 391 TVIEMKDTKIASLERNIRDLE---DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKT 447
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKA 799
++ + ++ ++++ +E + ++ S K I L+ES+ E R L+ +
Sbjct: 448 KIDQLKQELSKK--ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 505
Query: 800 DQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI-EHENKELQKKNQIL 858
D L L+EK+ ++ T Q +L L R + K +LE+ E + LQKK + L
Sbjct: 506 DALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM-KDMLEVKERKINVLQKKIENL 564
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLA----ESESTKYQTQLRDLESNLKRITHEH 914
E+ ++ L++++ +L ++ TD A E ++ + + L+ +R E
Sbjct: 565 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 624
Query: 915 QTLIVQKKKEIEDLEIEFN------TQIESAIRDKK----VLNEKYEKNIEYVTQLEAQL 964
I +KE +DL+ + N T+ ES++ D K L K + LE +
Sbjct: 625 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 684
Query: 965 QEYKNNIENLNM------NVEELNKMNLELID--KHVQKQQTQSPDYTEQYINEINKLNA 1016
++ K L N+E+ ++MN E D K + K+ + D + E+++L
Sbjct: 685 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 744
Query: 1017 LLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA-----QFTTKLENME--EEMQRVSK 1069
+LK+ + E ++KI + + + D K+A Q K +N + EE++R
Sbjct: 745 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 804
Query: 1070 QLLDSKQH--NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIE 1119
+ D+ QH EEL + + ++ K + + ++ + E + + IE
Sbjct: 805 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIE 856
Score = 78.6 bits (185), Expect = 2e-13
Identities = 153/741 (20%), Positives = 322/741 (43%), Gaps = 61/741 (8%)
Query: 620 ESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELA 679
+S DL +L LQ++ D + +L DI + + IK+ E K+E A
Sbjct: 157 DSTMLDLQAQLKELQRENDLLRKEL-DIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAA 215
Query: 680 LVIENLKLDKEQLYGTIKDLENDKEDI-MNKLQNYIQENMDLTDKLEKMSAEKISE-LLA 737
+ + KEQ+ + EN + + LQ+ ++ DL L++ S + +E
Sbjct: 216 ----RMSVLKEQM--RVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 269
Query: 738 KINHEEQSKIQTQFGIDAK-IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLE 796
++ E ++Q + AK + +E +E + K + +ESI + + L+
Sbjct: 270 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM---LQ 326
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQ 856
K L S E + + + V+ L V++D EK+ + H +EL +++Q
Sbjct: 327 SKG--LPSKSLEDDNERTRRMAEAESQVSHLEVILDQK---EKENI---HLREELHRRSQ 378
Query: 857 ILLEENQNLQI-SLSDMQQHYNALVEKANRTDLAESESTKYQTQLR--DLESNLKRI--- 910
+ E + + ++ +M+ A +E+ R E + K L D E +K+I
Sbjct: 379 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 438
Query: 911 -THEH--QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+H +T I Q K+E+ E E +++ + N +++IE L+ L
Sbjct: 439 KSHSKFMKTKIDQLKQELSKKESEL-LALQTKLETLSNQNSDCKQHIEV---LKESLTAK 494
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQ---YINEINKLNALLKQKDEE 1024
+ L V+ L ++ LE + + K+ Q D TE+ EI + +L+ K+ +
Sbjct: 495 EQRAAILQTEVDAL-RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 553
Query: 1025 IIALNQKINNAQVSYMS---MVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
I L +KI N Q +++ + ++ T N + + + + L + ++ E L
Sbjct: 554 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 613
Query: 1082 QILVREQDDQ--IKEL----KETK-LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXX 1134
+ RE+DD+ ++E+ KE K L ++N + E S++ + + A+++
Sbjct: 614 KEQ-RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLK 672
Query: 1135 XXXXXXXLKV---QEEEEFIQERSVLQ-----EQSAKLNTELQECYTKIIQLETLNTELT 1186
L++ Q++EE + + L+ E +++N E + +I QL+ +
Sbjct: 673 RDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFAD---QIKQLDKEASYYR 729
Query: 1187 GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQR 1246
Q ++++L L+++ E ++ +AEL S + + ++A L ++
Sbjct: 730 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK 789
Query: 1247 EADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEH 1305
+ + Q E R + S ++ ++ + ++ ++ ++ T ++ S Q L +KE H
Sbjct: 790 KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAH 849
Query: 1306 LRNLQEKYADVINQIEILRSE 1326
L NL+ + + +I ++ E
Sbjct: 850 LANLRIERRKQLEEILEMKQE 870
Score = 70.5 bits (165), Expect = 5e-11
Identities = 129/707 (18%), Positives = 283/707 (40%), Gaps = 62/707 (8%)
Query: 851 LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRI 910
L+++ ++ EENQ+LQ+++ +Q + + + E N +R+
Sbjct: 220 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 279
Query: 911 THEHQTLIVQK---KKEIEDLEIEFNTQIESA-IRDKKV------LNEKY--EKNIEYVT 958
EH + +K +E++E+ TQ ++ RD+ + L K K++E
Sbjct: 280 QAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDN 339
Query: 959 QLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQYINEINKLNAL 1017
+ ++ E ++ + +L + +++ K N+ L ++ H + Q P T+ I +
Sbjct: 340 ERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 399
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFT----------TKLENMEEEMQRV 1067
+ + I L +I + + + D E ++ Q TK++ +++E+ +
Sbjct: 400 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 459
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMN--IPKTEGMIISSTIEPMSDDA 1125
+LL + E L + I+ LKE+ E I +TE + +E
Sbjct: 460 ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 519
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTEL 1185
N L E + +L+ + K+N LQ+ ++E L +L
Sbjct: 520 NKKTKQLQDLTEEKGTLA----GEIRDMKDMLEVKERKINV-LQK------KIENLQEQL 568
Query: 1186 TGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA--VDQRGFEIAELWKQHL 1243
D +Q+ LK +++ L T++ N + +A L ++S + +R E E +
Sbjct: 569 RDKD----KQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 624
Query: 1244 AQREADFQKTEHELRVQLSAFES----KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKL 1299
+ F+K +L+ +++A ++ K L+D + ++ + + ++ SL+ +
Sbjct: 625 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 684
Query: 1300 QDKEEHLRNL--QEKYADVINQIEILRSEIEDE------KVAFXXXXXXXXXXXXXXXXD 1351
+ K+E L Q K A I + E D+ + ++ +
Sbjct: 685 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 744
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLE- 1410
+ E ++ K +++ I + + K A++LE + E
Sbjct: 745 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 804
Query: 1411 -LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHEN 1469
+ D+ + + E L + E + + +L ++ + EKE+ LA LR++ +
Sbjct: 805 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLA----EKEAHLANLRIERRKQ 860
Query: 1470 ANHYETMQKESEIERVKLIEELNVKITE-SVSLNKQVAELNKALEEE 1515
M++E+ + + ++ N+ + E S S K+ E AL+ E
Sbjct: 861 LEEILEMKQEALLAAIS-EKDANIALLELSASKKKKTQEEVMALKRE 906
Score = 64.5 bits (150), Expect = 3e-09
Identities = 100/516 (19%), Positives = 219/516 (42%), Gaps = 53/516 (10%)
Query: 476 NEIAKVQEQLK--QELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNH 533
+E+ +Q +L+ N + K +++ L E L + E++ L E+DA + + +S
Sbjct: 461 SELLALQTKLETLSNQNSDCKQ-HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 519
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
K KQ+Q + ++ EI + + L +K+ L+++ NLQ L D D
Sbjct: 520 NKKTKQLQDLTEEKGTLAG---EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 576
Query: 594 IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD 653
D K + + +T L + S+K +++ L +Q+ + ++L +I + +
Sbjct: 577 NLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLK--EQRERDDRERLEEIESFRKE 634
Query: 654 QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY 713
+ L+E+++AL A E + +LK L L+ D + + L+
Sbjct: 635 -------NKDLKEKVNALQAELTEKESSLIDLKEHASSLASA--GLKRDSK--LKSLEIA 683
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK 773
I++ + KLE ++L N E+ S++ +F +I++ D E K
Sbjct: 684 IEQKKEECSKLE-------AQLKKAHNIEDDSRMNPEFA--DQIKQLDKEASYYRDECGK 734
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
++ + RL E + +E+ + ++K +L S + + H
Sbjct: 735 AQAEVDRLLEILKEVENEKNDKDKKIAELES------------------------LTLRH 770
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+ K++ ++H + +KKN LLEE + + S++D QH + E N + E
Sbjct: 771 MKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-IEELMNALEKTRQEL 829
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
+ +L + +L L ++++K++E++ + +AI +K E +
Sbjct: 830 DATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELS 889
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ + ++ K + L +++ + ++L+
Sbjct: 890 ASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLM 925
Score = 60.5 bits (140), Expect = 5e-08
Identities = 140/706 (19%), Positives = 294/706 (41%), Gaps = 79/706 (11%)
Query: 835 RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESEST 894
+V + +L+++ + KELQ++N +L +E L I S + N++ + E
Sbjct: 154 QVRDSTMLDLQAQLKELQRENDLLRKE---LDIKDSKLGSSMNSIKTFWSPELKKERVLR 210
Query: 895 KYQTQLRDLESNLKRITHE---HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE 951
K + + R++HE H L +Q ++ + + N ++ ++ + E
Sbjct: 211 KEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIE 270
Query: 952 KNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEI 1011
E +L+A+ + L +EE+ ++ +E QKQ + D + + + E+
Sbjct: 271 LTEENFRRLQAEHDRQAKELFLLRKTLEEM-ELRIE-----TQKQTLNARDESIKKLLEM 324
Query: 1012 NKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
+ L + E+ +++ A+ S VS E L Q + ++ EE+ R S QL
Sbjct: 325 LQSKGLPSKSLEDDNERTRRMAEAE----SQVSHLEVILDQKEKENIHLREELHRRS-QL 379
Query: 1072 LDSKQHNEELQILVREQDDQIKELKETKL-TFEMNIPKTEGMIISSTIEPMSDDANNVDX 1130
+ LQ ++ E+K+TK+ + E NI E I+ + AN V
Sbjct: 380 QPEPAKTKALQTVI--------EMKDTKIASLERNIRDLE-----DEIQMLK--ANGV-- 422
Query: 1131 XXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDV 1190
L ++ EE I++ V + S + T++ + L EL+
Sbjct: 423 -----------LNTEDREEEIKQIEVYKSHSKFMKTKIDQ----------LKQELSK--- 458
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI---AELWKQHLAQRE 1247
+ ++ L++KLE L+ +N + + L+ S++ A +QR + + + L ++E
Sbjct: 459 -KESELLALQTKLETLSNQNSDCKQHIEVLKESLT-AKEQRAAILQTEVDALRLRLEEKE 516
Query: 1248 ADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLR 1307
+ K +L+ + ++ D +E V +++ +LQ +L+DK++ L
Sbjct: 517 SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 576
Query: 1308 NLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSI 1367
NL+++ ++ L+++ + A L+ + + + + + I
Sbjct: 577 NLKDR-------VKSLQTDSSNTDTALATLEEALSEKERIIER-LKEQRERDDRERLEEI 628
Query: 1368 LNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITL 1427
+ +EN LK+ + D + L +DS++ K+ E I +
Sbjct: 629 ESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKL--KSLE--IAI 684
Query: 1428 TQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
Q+ +E + QL + IED + E A ++ + A++Y +++ E +L
Sbjct: 685 EQKKEECSKLEAQLKKAHN-IEDDS-RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 742
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE-NQEIE 1532
+E L E +K++AEL + N+ L+ NQ++E
Sbjct: 743 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 788
Score = 50.0 bits (114), Expect = 7e-05
Identities = 73/370 (19%), Positives = 157/370 (42%), Gaps = 22/370 (5%)
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE--IAELWKQHLAQREA 1248
V+ E+ L+ ++ L E L T +L + RG E EL +++ + +A
Sbjct: 226 VSHEENQHLQLTIQALQDE----LRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA 281
Query: 1249 DFQKTEHEL---RVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNK-LQDKEE 1304
+ + EL R L E + E ++ ++ E K++ M Q L +K L+D E
Sbjct: 282 EHDRQAKELFLLRKTLEEMELRIETQKQTL-NARDESIKKLLEMLQSKGLPSKSLEDDNE 340
Query: 1305 HLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXX--XXXXDLRT--ENQSYK 1360
R + E + V + +E++ + E E + L+T E + K
Sbjct: 341 RTRRMAEAESQV-SHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 399
Query: 1361 QMQ-EQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK 1419
E++I ++ +E LK + ++ ++ + +++ E+ +K
Sbjct: 400 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 459
Query: 1420 THEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKE 1479
E + L + + N ++ + +++ KE AIL+ ++ +A +KE
Sbjct: 460 ESEL-LALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV--DALRLRLEEKE 516
Query: 1480 SEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDE 1539
S + K ++L E +L ++ ++ LE + K N +Q +EN + ++ + +
Sbjct: 517 SFLN--KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ 574
Query: 1540 ITNLQNMVRA 1549
+TNL++ V++
Sbjct: 575 LTNLKDRVKS 584
Score = 44.4 bits (100), Expect = 0.003
Identities = 102/577 (17%), Positives = 220/577 (38%), Gaps = 51/577 (8%)
Query: 1014 LNALLK--QKDEEIIALNQKINNAQV-SYMSMVSDYESKLAQFTTKLENMEEEMQRVSK- 1069
L A LK Q++ +++ I ++++ S M+ + + S + L E V K
Sbjct: 163 LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE 222
Query: 1070 QLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
Q+ S + N+ LQ+ ++ D+++ ++ + TIE ++ +
Sbjct: 223 QMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF--TIELTEENFRRLQ 280
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQ---ERSVLQEQSAKLNTELQECYTKIIQLETL--NTE 1184
L+ EE ++ ++ L + + L+ +K + ++L + E
Sbjct: 281 AEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNE 340
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE-IAELWKQHL 1243
T + Q++ L+ L+Q EN +L + + + + E+ +
Sbjct: 341 RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKI 400
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE 1303
A E + + E E+++ + E + ++ +++ ++ L+ +L KE
Sbjct: 401 ASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 460
Query: 1304 EHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXX-DLRTEN-QSYKQ 1361
L LQ K + NQ + IE K + LR E +S+
Sbjct: 461 SELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN 520
Query: 1362 MQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
+ + + ++ EE L ++N + K+ L QL KD +
Sbjct: 521 KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ------ 574
Query: 1422 EYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESE 1481
LT D ++++ + ++ LA L + E E ++++ E
Sbjct: 575 -----LTNLKDRVKSLQTD-----------SSNTDTALATLEEALSEKERIIERLKEQRE 618
Query: 1482 IERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEIT 1541
+ + +EE+ S K+ NK L+E+V N +Q L +E ++ L + +
Sbjct: 619 RDDRERLEEIE-------SFRKE----NKDLKEKV---NALQAELTEKESSLIDLKEHAS 664
Query: 1542 NLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
+L + SK+ K + A + K+ +L+ + K
Sbjct: 665 SLASAGLKRDSKL-KSLEIAIEQKKEECSKLEAQLKK 700
Score = 40.7 bits (91), Expect = 0.042
Identities = 57/281 (20%), Positives = 115/281 (40%), Gaps = 18/281 (6%)
Query: 72 KEHRKATAELLG-RPFVPGISESLANTLKQKEILMEKI--KQYKELSKRSSTTIVRXXXX 128
+E K +ELL + + +S ++ + E+L E + K+ + ++ +R
Sbjct: 454 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 513
Query: 129 XXXXXXXXXXXQLGDVTH----LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD- 183
QL D+T L+ I++ + L V + K+ +++ I +LQE++ +KD
Sbjct: 514 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDK 573
Query: 184 QIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDI 243
Q+ K++ + E+ + ++ E E +D+++R L++I
Sbjct: 574 QLTNLKDRVKS--LQTDSSNTDTALATLEEALSEKERIIERL--KEQRERDDRER-LEEI 628
Query: 244 ESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPS 303
ES L+E L+A E++ + S L E L +S+E +
Sbjct: 629 ESFRKENKDLKEKVNALQA---ELTEKESSLIDLKEHASSLASAGLKRDSKL--KSLEIA 683
Query: 304 CEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKE 344
E+K E K ++ + + QI+Q +KE
Sbjct: 684 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE 724
>AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1116
Score = 84.2 bits (199), Expect = 3e-15
Identities = 161/784 (20%), Positives = 333/784 (42%), Gaps = 59/784 (7%)
Query: 466 IHVGTN-TEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANK 524
IHV + TED + +V+ + + + + N + L L + E ++ +E NK
Sbjct: 147 IHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK 206
Query: 525 NMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLH 584
++ + L K+ T+ + SN +I ELH QK E+E+ ++L
Sbjct: 207 QIVHFQQELSLSEKK-NLTLSKEVQQIQSNYDIA--IAELH--VQKSKNQEQEEKIMKLS 261
Query: 585 LVDYDSGRMIESDVYKKMIEMENLAETR-LKAISLLESQKFDLVQELHILQQKYDEVEDK 643
+ R I ++V + + + E R L ++S + + DL+ L L +E
Sbjct: 262 NEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISN--IDLLN-LRDLSNGSEEDNLP 318
Query: 644 LADISQLQSDQVCS-EIKSVHLEE--QIDALSASKKELALVIENLKLDKEQLYGTIKDLE 700
+ L +D + S ++K ++E + ++ +S + + + + + I++LE
Sbjct: 319 NTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELE 378
Query: 701 NDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISE---LLAKINHEEQSK-----IQTQFG 752
E + +++ Y EN L +K K + + E L+ ++ E Q K +Q Q
Sbjct: 379 QQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHV 438
Query: 753 IDAKIQERDL---------YIENIESELSKYK---SRICRLEESIAVMEDRRYSLERKAD 800
++ K +L I+ +E+ L K S +LE+ I E LER
Sbjct: 439 VEGKRALSELTQGVTCYKAKIKELETILETQKVERSHSAKLEQDILEKESIILKLERNLK 498
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+ +LQ+ K + ++E +L + L ++ + + K LL+++ E +E ++ L+
Sbjct: 499 EFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLK 557
Query: 861 ENQNLQISLSDMQQHYNALVEK-ANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
E L S + Q L K + DL E + T + Q++ ++ + + E + L +
Sbjct: 558 E--ELSASSARTQNLKADLQRKEEDYADLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRI 614
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
K E+E + + + +++ R + L E+ ++E +Q+Y+ ++LN+ +
Sbjct: 615 -KINELEKKKNQCSQELDMKQRTIQQLKEQLNNQ-----KVEEAIQQYERACKDLNVKEK 668
Query: 980 ELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSY 1039
+ M + L ++ ++ Q + E + E+ +L L++ E+ L K N
Sbjct: 669 IIEDMRMTLEEQ--EQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKE 726
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSK-----QHNEELQILVREQDDQIKE 1094
+D KL +L+ E++ K+ L+ K Q E I +E ++
Sbjct: 727 HENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAED 786
Query: 1095 LKE-TKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQE 1153
+ K EM I + S ++ ++ + + VQ++ E Q
Sbjct: 787 RERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQL 846
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQL---ETLNTE-LTGHDVVNQEQINQLKSKLE--QLN 1207
+ ++ E S K+ T++ + K I + L TE L+ +++ +I L+ +++
Sbjct: 847 KRIISETS-KIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVS 905
Query: 1208 TEND 1211
TEND
Sbjct: 906 TEND 909
Score = 80.2 bits (189), Expect = 6e-14
Identities = 166/840 (19%), Positives = 348/840 (41%), Gaps = 89/840 (10%)
Query: 761 DLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQE 820
+L I++EL+K K + + +E L+++ ++ S +QE + + + I +
Sbjct: 10 ELKFNQIKAELAKTKGELIKTKEE----------LKKRENESDSLIQELETSIKKI-ITQ 58
Query: 821 DELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV 880
++ + L ++D +K+ E +N + +N + + + + + N V
Sbjct: 59 NQRIKELINIID-----QKEDTINEFQNLKSLMENTFKCNDKADTSSLIINNKLICNETV 113
Query: 881 E--KANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIES 938
E K +++ + + +L+ E K+ + + I + +K+ E++ +
Sbjct: 114 EVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI-----A 168
Query: 939 AIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH---VQK 995
I D +VL E E ++ +E +L+ K LN + + L L +K + K
Sbjct: 169 EIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQ-ELSLSEKKNLTLSK 227
Query: 996 QQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE---SKLAQ 1052
+ Q + I E++ + ++++E+I+ L+ +I A S + VS + +K+ +
Sbjct: 228 EVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDE 287
Query: 1053 FTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI--PKTE 1110
T L+++ + L D +EE + + D + +K E I P E
Sbjct: 288 LRT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRE 346
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ------EEEEFIQERSVLQEQSAKL 1164
SS IE + ++ + L+ Q E + + E + L+E+ K
Sbjct: 347 NSFHSS-IEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKN 405
Query: 1165 NTELQECYTKIIQLETLNTELTGHDVVNQEQINQL---KSKLEQLNTENDNLLSTVAELR 1221
+L + +IQ L EL +V QI + K L +L + + EL
Sbjct: 406 QDDLLKEKETLIQ--QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE 463
Query: 1222 SSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE 1281
+ + + +R A+L +Q + ++E+ K E L+ F+ E L DSV+++
Sbjct: 464 TILETQKVERSHS-AKL-EQDILEKESIILKLERNLK----EFQ---EHLQDSVKNTKDL 514
Query: 1282 ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXX 1341
++ E++T L N LQD +HL L+E+ + Q E EK+
Sbjct: 515 NVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ--------ETEKL--KEELSAS 563
Query: 1342 XXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAK 1401
DL+ + + Y ++E+ + + ++ Q++K ++N+ E K
Sbjct: 564 SARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKK 622
Query: 1402 VLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAI 1461
+ + +L++K I Q Q N+ + V + + +YE+ +DL KE +
Sbjct: 623 KNQCSQELDMKQRTIQQLKE-------QLNN--QKVEEAIQQYERACKDLNV-KEKIIED 672
Query: 1462 LRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNE 1521
+R+ + E +T ++ ++ KL EE+ TE ++ +L + K +E
Sbjct: 673 MRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATELEKWKEKCNDLETKNNQRSNKEHE 728
Query: 1522 MQTALENQEIEIVTLNDEITNLQNMVRASSSK-IQKHVSFASDTKQGRDEQLDNTMNKEL 1580
T + ++ L DE+ + A K +++ + + K+ +N NKE+
Sbjct: 729 NNTDVLG---KLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEA-----ENIRNKEM 780
Score = 77.4 bits (182), Expect = 4e-13
Identities = 177/912 (19%), Positives = 376/912 (41%), Gaps = 73/912 (8%)
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
C E+K ++ + L+ +K EL E LK + + I++LE + I+ + Q I+
Sbjct: 8 CLELKFNQIKAE---LAKTKGELIKTKEELKKRENESDSLIQELETSIKKIITQNQR-IK 63
Query: 716 ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYK 775
E +++ D+ E + + L + + E K + + I L K
Sbjct: 64 ELINIIDQKED-TINEFQNLKSLM--ENTFKCNDKADTSSLIINNKLICNETVEVPKDSK 120
Query: 776 SRICRLEESIAVMEDRRYSLERKADQL--GSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
S+IC + + E ++ K + S + E QK E E+ + + VL ++
Sbjct: 121 SKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIED-IRVLQEN 179
Query: 834 DRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+ + LL IE+E K + EE L + QQ + L EK N T E +
Sbjct: 180 NEGLRAFLLTIENELKNEK-------EEKAELNKQIVHFQQELS-LSEKKNLTLSKEVQQ 231
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IESAIRDKKVLNEKYE- 951
+ + E ++++ ++ Q + K EIE T+ I + + K+++ K +
Sbjct: 232 IQSNYDIAIAELHVQKSKNQEQEEKIMKLSN----EIETATRSITNNVSQIKLMHTKIDE 287
Query: 952 -KNIEYVTQLE----AQLQEYKNNIENLNMNVEELNKM-NLELIDKHVQKQQTQSPDYTE 1005
+ ++ V+Q+ L++ N E N+ +L+ + N L+ K V++ + Q P+
Sbjct: 288 LRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNREN 347
Query: 1006 QYINEINKL----NALLK---QKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK-L 1057
+ + I + ++K +K +I L Q+I Q D ++L + K
Sbjct: 348 SFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY-KDENNRLKEKEHKNQ 406
Query: 1058 ENMEEEMQRVSKQLLDSKQH-NEELQILVR---EQDDQIKELKETKLTFEMNIPKTEGMI 1113
+++ +E + + +QL + Q N L + ++ E + EL + ++ I + E ++
Sbjct: 407 DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETIL 466
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER----SVLQEQSAKLNTELQ 1169
+ +E D ++E +E +Q+ L + KL E+
Sbjct: 467 ETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT 526
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD 1229
+ + ++ L + N+++ +LK +L + NL A+L+ D
Sbjct: 527 QLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK---ADLQRKEEDYAD 583
Query: 1230 QRGFEIAELWKQ-HLAQREADFQKTEHEL-RVQLSAFESKYEQL---LDSVQSSTQ---E 1281
+ ++ + KQ Q+E + E +L R++++ E K Q LD Q + Q E
Sbjct: 584 LKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE 642
Query: 1282 ETNKIVTMEQVTSLQNKLQD---KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
+ N E + + +D KE+ + +++ + Q ++ + ++ + K+
Sbjct: 643 QLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ-EQTQVEQDQVLEAKLEEVERL 701
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
DL T+N + ++ ++ + L+ R
Sbjct: 702 ATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNADRKKWL 759
Query: 1399 EAKVLELTHQLE---LKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEK 1455
E K++ +T E +++ E+ + + Q+N E E + QL E + ++ E+
Sbjct: 760 EEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN-EMEILTAQLTEKDSDLQKWREER 818
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
+ +A L +++ A +QK++EIE++K I KI E+ ++ + ++ A + +
Sbjct: 819 DQLVAALEIQL--KALISSNVQKDNEIEQLKRIISETSKI-ETQIMDIKPKRISSA-DPD 874
Query: 1516 VAKTNEMQTALE 1527
+T + T+ E
Sbjct: 875 KLQTEPLSTSFE 886
Score = 59.3 bits (137), Expect = 1e-07
Identities = 133/726 (18%), Positives = 305/726 (42%), Gaps = 50/726 (6%)
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDL-VDKEYVISEKDTXXXXXXXXXXGKDTLIA 450
E NQD K + I +L+ +Q N L V ++V+ K K I
Sbjct: 402 EHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK-AKIK 460
Query: 451 QLQ--LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ---ELNDEIKDVNVKDLIEKL 505
+L+ LE Q+ S E + I K++ LK+ L D +K N KDL K
Sbjct: 461 ELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVK--NTKDLNVKE 518
Query: 506 KSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELH 565
+E+ITQL + + K+++++K + +Q + + ++S S+ L +L
Sbjct: 519 LKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNLKADLQ 575
Query: 566 HLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM-IEMENLAETRLKAISLLESQKF 624
+ A+L+E+ + + + + D K + I++ L + + + SQ+
Sbjct: 576 RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC-----SQEL 630
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSE--IKSVHLEEQIDALSASKKELALVI 682
D+ Q +QQ +++ ++ + + Q ++ C + +K +E+ L ++
Sbjct: 631 DMKQRT--IQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQD 688
Query: 683 ENLKLDKEQLYGTIKDLE------NDKEDIMNKLQNYIQEN-MDLTDKLEKMSAEKISEL 735
+ L+ E++ +LE ND E N+ N EN D+ KL + E + E
Sbjct: 689 QVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE-LQES 747
Query: 736 LAKINHEEQSKIQTQFGIDAKIQE----RDLYIENIESELSKYKSRICRLEESIAVMEDR 791
K N + + ++ + + + +E R+ ++ + ++ + +E A + ++
Sbjct: 748 EQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEK 807
Query: 792 RYSLER---KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
L++ + DQL + L+ + KA +Q+D + +L ++ +E Q+++I+ +
Sbjct: 808 DSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKR 867
Query: 849 KELQKKNQILLEE-NQNLQISLSDMQQHYNALVEKANRTDLAESESTKY-----QTQLRD 902
+++ E + + +IS + ++ ++V + +ST++ + Q
Sbjct: 868 ISSADPDKLQTEPLSTSFEISRNKIED--GSVVLDSCEVSTENDQSTRFPKPELEIQFTP 925
Query: 903 LESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEA 962
L+ N + H T V K + + + N E ++ + N N+++ +
Sbjct: 926 LQPNKMAVKHPGCTTPVTVKIP-KARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDR 984
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
K + + ++ + + V + +++ + + ++L+ K
Sbjct: 985 NSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKA 1044
Query: 1023 EEIIAL--NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEE 1080
++II + K++N + S ++ +K +T+++ + + +V L+D K +
Sbjct: 1045 KKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVI--LMDQKMKESD 1102
Query: 1081 LQILVR 1086
QI+ R
Sbjct: 1103 HQIIKR 1108
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 503 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 561
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 562 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 617
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 618 ELEKKKNQCSQELD 631
>AL590377-2|CAI14630.2| 1406|Homo sapiens chromosome 9 open reading
frame 39 protein.
Length = 1406
Score = 84.2 bits (199), Expect = 3e-15
Identities = 226/1183 (19%), Positives = 488/1183 (41%), Gaps = 104/1183 (8%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE----KLKSAEEQITQLNDEIDAANKN 525
TN + ++ V E+ KQ+ E KD V ++++ K++ E++ + L EI+ K
Sbjct: 136 TNPDLTQVVSLVVEREKQK--SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR 193
Query: 526 MIKVKSNHKLKLKQ---MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
I V + K+ ++K + S+ KE V+ EE + L K LEEE L
Sbjct: 194 KIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK--NLEEENKKLS 251
Query: 583 LHLVDY--DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
D D ++ + + + + + A+ + +L+E++K E+ + Q KY+
Sbjct: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----EVEVSQSKYNAL 306
Query: 639 --EVEDKLADISQLQSD--QVCSEIKSV-HLEEQIDALSASKKELALVIENLKLDKEQLY 693
++ +K ++ Q D V E++ + +L +Q +A + EL ++ L +D +++
Sbjct: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
+D+ + KL N + + T E M + ++ L ++ +EQ + +
Sbjct: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK----L 422
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
K+QE + E S S++ +E S + + + YLQEK K
Sbjct: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE----YLQEKLKIA 478
Query: 814 SEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEENQNLQISL 869
+E I ++ +R +++ + ++ ++ ++ L K+ EE Q L+ +
Sbjct: 479 NEKLSENISANKGFSRKSIMTSAEGKHKEPPVK---RSRSLSPKSSFTDSEELQKLRKAE 535
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDL 928
++ AL K+ D K + +L+ L++N + + + Q EI +
Sbjct: 536 RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
Query: 929 EIEFNTQIESAIRDKKVLNE-KYEK--NIEYVTQ---LEAQLQEYKNNIENLNMNVEELN 982
+ Q+ D V NE Y K N E + Q LE +L E K +I ++ELN
Sbjct: 596 KRADPQQLRQEDSDA-VWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELN 654
Query: 983 KMNLELIDKHVQKQ-----------QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ E ++ + + + + EQ + ++ +L LK ++ ++K
Sbjct: 655 RCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKR----SRK 710
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ M +S L Q E E+E++++ K D ++ N ELQ+ + E + +
Sbjct: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEF 1150
+ L+ + E N + E I PM + D +KV+ +
Sbjct: 771 VTSLR--RQVAEANALRNEN---EELINPMEKSHQSAD----RAKSEMATMKVRSGRYDC 821
Query: 1151 IQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ ++ ++AK N + +T + ++ ++ E +++ S E ++
Sbjct: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ 881
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ-------KTEHELRVQLS 1262
L + + E IS D + + ++ + Q + Q KT + +
Sbjct: 882 --TLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKN 939
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
A + +++ +Q S+ V E+ ++ Q ++ L+E+ + Q +
Sbjct: 940 AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI--TAQKSSSNIILLRERIISLQQQNSV 997
Query: 1323 LRSEIEDEKVA---FXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILNINEENAQLK 1378
L++ + +++ + +T Q+ K++ + + L +E+ K
Sbjct: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLEL--THQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
S +V +V L + ++L+ ++ K T LT+++ +
Sbjct: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKT 1117
Query: 1437 VRQQLVEYEKRIEDLTYEKESEL-AILRLKMH--ENANHYETMQKESEIERVKLIEELNV 1493
++ +L+ E+ I+++ +EK S + + +K H E+ + + ES ++++ L+
Sbjct: 1118 LKFELLAKEEHIKEM-HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK 1176
Query: 1494 KI---TESVSLNKQVA--ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
K+ TE S NK+V+ L + L V + ++ + + + E+ + ++T L + +
Sbjct: 1177 KVKTLTEECS-NKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRIS 1235
Query: 1549 ASSSKIQKHVSFASDTKQG---RDEQLDNTMNKELLDAVPRAE 1588
+ S + + + AS Q + EQ+ K LL A + E
Sbjct: 1236 ETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVE 1278
Score = 62.9 bits (146), Expect = 9e-09
Identities = 134/722 (18%), Positives = 284/722 (39%), Gaps = 37/722 (5%)
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
++ +++E++L ++ E Q + + + LQ++ D+ Q + +VE+ + A
Sbjct: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ Q++D + ++ L K+EI DL + + A+ ++ K
Sbjct: 158 KDRKVLEILQVKD--AKIQEFEQRESVL----KQEINDL-----VKRKIAVDEENAFLRK 206
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
++E + + + QE K+ E + N EE N++ ++ +++ +K T+ D +
Sbjct: 207 EFSDLE--KKFKDKSQEIKDTKECV-QNKEEQNRLVIKNLEEENKKLSTRCTDLLND-LE 262
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ K A L+++ A + + + V +SK + +L N + E+ +
Sbjct: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDM 322
Query: 1070 QLLDSKQHNEELQILVREQDD---QIKELKETKLTFEMNIPKT-EGMIISSTIEPMSDDA 1125
+ ++ +ELQ L ++ Q EL + M+ K T E +S
Sbjct: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ-SAKLNTELQECYTKIIQLETLNTE 1184
+ +++ +Q++ + +EQ +AKL +LQE + L +
Sbjct: 383 LYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAELWKQHL 1243
V ++ ++ L++ + +E + L + +S + +GF +
Sbjct: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAE 502
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK 1302
+ + K L + S +S+ Q L + + E + ++ L++ + +
Sbjct: 503 GKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
Query: 1303 EEHLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
+E L+ LQ Y V + Q E E K+ +L +
Sbjct: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLELKDSEIYQ 1418
+++ Q +N+ EE +LK V + E ++ E+K S +
Sbjct: 623 QELMIQK-MNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK 681
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
E Q+ E EN + + +++++ + E L+ + + ET +K
Sbjct: 682 NGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREK 741
Query: 1479 ESE--IERVKLIE----ELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E E I+ K +E EL VKI TE SL +QVAE N E N M+ + ++
Sbjct: 742 ELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQS 801
Query: 1529 QE 1530
+
Sbjct: 802 AD 803
Score = 59.7 bits (138), Expect = 9e-08
Identities = 73/354 (20%), Positives = 157/354 (44%), Gaps = 35/354 (9%)
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGT--IKD--LENDKEDIMN---KLQNYI 714
+ L++Q L +KK L ++ K E+L + D + ++ I L
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
Query: 715 QENMDLTDKLEKMSA-EKISELLAKINHE--EQSKIQTQFGIDAKIQERDLYIENIESEL 771
+E DL KLE S ++E +++ + + + +D ++++ ++N +EL
Sbjct: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+K S + L+ + E+ + K ++ E+ + I++ L R V +
Sbjct: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRM-----ERDITMKRHLIED--LKFRQKVNL 1161
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
+ ++ + L + L KK + L EE N ++S+ ++Q N V++ ++ +
Sbjct: 1162 ESNKSFSEML-------QNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
Query: 892 ESTKYQTQLRDLESNL--KRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+S K + + +DL+ L RI+ + K++++L ++ +E A + +
Sbjct: 1215 KS-KEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLA 1273
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQT 998
NEK E+ + T ++A +E +N++ + + EL KM N + K QT
Sbjct: 1274 NEKVEE---FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQT 1324
Score = 53.2 bits (122), Expect = 7e-06
Identities = 207/1153 (17%), Positives = 450/1153 (39%), Gaps = 107/1153 (9%)
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQR-LLKDIESKDVRISSLEEANKLLEAARFEIS-LEH 271
T +T++ + E + + K R +L+ ++ KD +I E+ +L+ EI+ L
Sbjct: 136 TNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQ---EINDLVK 192
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAK-QSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K+A + E K Q I+ + E EE+ L I N+ E KK+
Sbjct: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
Query: 331 --LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
+ LN + +E + T++K + + + + +RK + SK + Q
Sbjct: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTF---EDNLIEARKEVEVSQSKYNALSLQ 309
Query: 389 LSS---ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
LS+ E + +D D + + E+ +L+ + + + + +I + +
Sbjct: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQELNDEIKDVNVKDLI 502
+ + + +Q+ + T + + + +Q+QL Q+ + K L
Sbjct: 370 EDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK------LK 423
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKL+ ++ L E D + H+ L ++ + VS + EI L E
Sbjct: 424 EKLQESQGAPLPLPQESDPDYSAQVP----HRPSLSSLETLM-----VSQKS-EIEYLQE 473
Query: 563 ELHHLSQKVAE-LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
+L ++K++E + KG + ++ G+ E V + + T + + L
Sbjct: 474 KLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRK 533
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ + LQ K E D+L D + + +++ + ++EQ+ +
Sbjct: 534 AERKIENLEKALQLKSQE-NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSG-MTE 591
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKI 739
+ + + D +QL + D + + N+L + +EN +L ++KM+ E+ + EL I
Sbjct: 592 IRKIKRADPQQLR------QEDSDAVWNELAYFKRENQELM--IQKMNLEEELDELKVHI 643
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY------KSRICRLEESIAVMEDRRY 793
+ ++ + IQ A+ +E L+ + E+ + K + + + + +E+R
Sbjct: 644 SIDKAA-IQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLK 702
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S E+++ +L +E K + + D L + L + EK+L +I +K+++K
Sbjct: 703 SFEKRSRKL----KEGNKKLMK---ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
EN LQ+ +S+++ +L + + +E+ + + + R E
Sbjct: 756 -------ENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSE 808
Query: 914 HQTLIVQK-----KKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNI-EYVTQ------ 959
T+ V+ K + ++ + + S R VLN K N+ E +++
Sbjct: 809 MATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDV 868
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ-------QTQSPDYTEQYINEIN 1012
E+ + L + E ++ D QK+ QTQ + + Y+N
Sbjct: 869 SESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDG 928
Query: 1013 KL-NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
K K+ + +K Q S + V ++ + + + +++
Sbjct: 929 KTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERI 988
Query: 1072 LDSKQHNEELQILVREQDDQIKELKET--KLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +Q N LQ + + +KE KE KL + + TI+ + N+D
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKL-----NLD 1043
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
K++ E S+ +E S +Q T + +++ E+
Sbjct: 1044 LAGLRKEKEDLLKKLESSSEI---TSLAEENSQVTFPRIQ--VTSLSPSRSMDLEMKQLQ 1098
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ N+L + + T LL+ ++ + + + +I K+HL +
Sbjct: 1099 YKLKNATNELTKQSSNVKTLKFELLAKEEHIK-EMHEKISRMERDIT--MKRHLIEDLKF 1155
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
QK E +F + L V++ T+E +NK V+++ + N ++ +
Sbjct: 1156 RQKVNLESN---KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQM 1212
Query: 1310 QEKYADVINQIEI 1322
+K + + + ++
Sbjct: 1213 YQKSKEELEKKDL 1225
Score = 34.7 bits (76), Expect = 2.8
Identities = 72/386 (18%), Positives = 153/386 (39%), Gaps = 42/386 (10%)
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+L +L EL ++E + L +L+ N + ++S V E S A D++ EI
Sbjct: 108 ELSSLKEELALCQA-DKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEIL 166
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
++ K Q +F++ E L+ +++ D V+ + ++ + L+
Sbjct: 167 QV-KDAKIQ---EFEQRESVLKQEIN----------DLVKRKIAVDEENAFLRKEFSDLE 212
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
K +DK + +++ +E + Q ++ +E+E DL +
Sbjct: 213 KKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEEN-----------KKLSTRCTDLLNDL 261
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
+ ++ + ++ +E V +++K L+ QL K +E+
Sbjct: 262 EKLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTEL 317
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETM 1476
QK + T+ + + E +N+ +Q + + +L +L +L + + + E +
Sbjct: 318 IQKDMDITL-VRKELQELQNLYKQNSTHTAQQAELI----QQLQVLNMDTQKVLRNQEDV 372
Query: 1477 QKESEIERVKLIEELNV--KITES--VSLNKQVAELNKAL---EEEVAKTNEMQTALENQ 1529
I KL EL++ + T+S L + V L L E+E AK E +
Sbjct: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
Query: 1530 EIEIVTLNDEITNLQNMVRASSSKIQ 1555
+ + +D + Q R S S ++
Sbjct: 433 PLPLPQESDPDYSAQVPHRPSLSSLE 458
>AL365436-2|CAI16590.1| 1203|Homo sapiens cingulin protein.
Length = 1203
Score = 84.2 bits (199), Expect = 3e-15
Identities = 145/824 (17%), Positives = 333/824 (40%), Gaps = 59/824 (7%)
Query: 318 IANMTELTKKIELLEH-LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR 376
+A ELT+K+E L+ L+ ++++ K LE + + + + + L+ R+ G
Sbjct: 358 VAGQGELTRKVEELQRKLDEEVKKRQK-LEPSQVGLERQLEEKTEECSRLQELLERRKGE 416
Query: 377 NTASKMKSPWSQLSSETLNQDTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
S + Q L+Q D + + ++ +L+ ++ + KE ++ +
Sbjct: 417 AQQSNKEL---QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETR 473
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
GK + QL+L ++ + + D E+ V++Q +++
Sbjct: 474 ELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDT------ 526
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
E+L+ + + TQ + ++A + M + + +L++ + ++ + NK
Sbjct: 527 -------EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
Query: 556 EIVRLT-EELHHLSQKVAELEEEKGNL------QLHLVDYDSGRMIESDVYKKMI----- 603
E +R T +EL L + E+EEE G +L +G + +V KK +
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYD---EVEDKLADISQL--QSDQVCSE 658
E++ L R + +L ++L +L+ + D E+E++ + + Q Q C E
Sbjct: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
Query: 659 IKSVHLEEQIDALSASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE 716
+ + +A ++ A+ + + + ++ I LE ++ +
Sbjct: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
Query: 717 NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
L DKL+++ AEK + E L EE S + ++A+++E + + E
Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
Query: 775 KSRICR-------LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ L A +E+++ L+R D+L L EK S+ +Q+ +
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL-EKIGEDSKQALQQLQ----- 873
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A L D+ +++ + + + K+ + + LQ + ++Q A +A R D
Sbjct: 874 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQA--SQAER-D 930
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
A + +L+ LE + Q ++ K +E+ T+++ ++L
Sbjct: 931 TARLDKELLAQRLQGLEQEAEN-KKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLT 989
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
++ + + V QL +L + ++ ++L + L + N +L + + Q P +
Sbjct: 990 DRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQ 1049
Query: 1008 INEINK-LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ N+ L L+ ++ E L + + E + + + + ++
Sbjct: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKA 1109
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
+ +Q+ ++++ E L L ++ +++E E + I E
Sbjct: 1110 LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153
Score = 69.3 bits (162), Expect = 1e-10
Identities = 118/677 (17%), Positives = 292/677 (43%), Gaps = 49/677 (7%)
Query: 221 MQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQ 280
++E + + E + +Q+ +D E + + + +LEA R ++S L +ELE+
Sbjct: 504 LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
Query: 281 XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE-EKGSLEIANMTELTKKIELLEHLNCQIR 339
K+ + + +E ++ EK +E EL +KIE+L+ Q R
Sbjct: 564 TSEETGHWQSMFQK-NKEDLRATKQELLQLRMEKEEME----EELGEKIEVLQRELEQAR 618
Query: 340 QT---NKELE-NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLN 395
+ +++E K + T+ + +++ S + +GR+ +++ QL+ +
Sbjct: 619 ASAGDTRQVEVLKKELLRTQEELKELQAERQSQEV---AGRHRDRELE---KQLAVLRVE 672
Query: 396 QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
D +++ + + +L+ +Q L +D + + +T + + Q E
Sbjct: 673 ADRGRELEEQNL-QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE 731
Query: 456 HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIK--DVNVKDLIEKLKSAEEQIT 513
+ + ++ + ++ + E ++ L D+++ + + L E L +++E+
Sbjct: 732 NDEFRR--RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEG 789
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAE 573
L A + + + +L Q Q+T++ + +E++R + +++ +
Sbjct: 790 SLAAAKRALEARLEEAQRG-LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 848
Query: 574 LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHIL 633
++ N +L + DS + ++ + ++E+ E + ++ + Q D E
Sbjct: 849 RTVDRLNKELEKIGEDSKQALQ----QLQAQLEDYKEKARREVADAQRQAKDWASEAEKT 904
Query: 634 QQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
++D++ + Q LQ+ Q +E + L++++ L+ + L EN K ++
Sbjct: 905 SGGLSRLQDEIQRLRQALQASQ--AERDTARLDKEL--LAQRLQGLEQEAENKKRSQDDR 960
Query: 693 YGTIKDLE----------NDKEDIMNKLQNYIQENMDLTDKL--EKMSAEKISELLA--K 738
+K LE +++++ + L + + D D+L E M + L K
Sbjct: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
Query: 739 INHEEQSK-IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
I+ E Q+K ++T+ Q+ + +ES+ + R+ E V++ LER
Sbjct: 1021 ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1080
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
K +L ++++++ ++ Q+D+L R+ L E+++ ++ K+ Q++ +
Sbjct: 1081 KVKELSIQIEDERQHVND---QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
Query: 858 LLEENQNLQISLSDMQQ 874
E N+ LQ + +++
Sbjct: 1138 QHEVNEQLQARIKSLEK 1154
Score = 64.9 bits (151), Expect = 2e-09
Identities = 144/814 (17%), Positives = 326/814 (40%), Gaps = 47/814 (5%)
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
L+RK D+ ++++QK E +L + ++E++ E + NKELQ
Sbjct: 371 LQRKLDE---EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ LL++ ++L+ L ++ + A+ K + R+L +
Sbjct: 428 KR-LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-------TQ----LEAQ 963
+ + +++E+ L+ ++ S ++ + + ++Y+++ E + TQ LEA+
Sbjct: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE 546
Query: 964 LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
Q+ + L +EE ++ QK + ++ + + + ++ E
Sbjct: 547 RQKMSALVRGLQRELEETSEETGHW-QSMFQKNKEDLRATKQELLQLRMEKEEMEEELGE 605
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE-ELQ 1082
+I L +++ A+ S K T+ E E + +R S+++ + E E Q
Sbjct: 606 KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQ 665
Query: 1083 ILV-REQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V R + D+ +EL+E L + + + ++ M +A
Sbjct: 666 LAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL 725
Query: 1142 LKVQEEEEFIQERSVLQEQSAKLNTELQE--------CYTKIIQLETLNTELTGHDVVNQ 1193
+ QEE + + R + EQ K L + K+ +LE +L +Q
Sbjct: 726 RETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQ 785
Query: 1194 EQINQL---KSKLEQLNTENDNLLSTVAELRSSISSAVDQRG--FEIAELWKQHLAQREA 1248
E+ L K LE E L+ + + + +++ A+++ G E+ K L +++
Sbjct: 786 EEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKR 845
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
+T L +L +Q L +Q+ ++ K +V Q + +D
Sbjct: 846 LLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEK--ARREVADAQRQAKDWASEAEK 903
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQE---Q 1365
+ + ++I+ LR ++ + A L E ++ K+ Q+ +
Sbjct: 904 TSGGLSRLQDEIQRLRQALQASQ-AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRAR 962
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+ + E+ ++L+ RVN +V +L +L +++ Q I
Sbjct: 963 QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL-MQERSARQDLECDKI 1021
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLT-YEKESELAILRLKMHENANHYETMQKESEIER 1484
+L ++N + + ++K L+ E +++L RL+ E +T+ + + +
Sbjct: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE---KTVLQSTNRKL 1078
Query: 1485 VKLIEELNVKI-TESVSLNKQVAELN---KALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
+ ++EL+++I E +N Q +L+ KAL+ +V + E L+ + +E
Sbjct: 1079 ERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQ 1138
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
+ ++A ++K S+ ++ + L N
Sbjct: 1139 HEVNEQLQARIKSLEKD-SWRKASRSAAESALKN 1171
Score = 42.3 bits (95), Expect = 0.014
Identities = 122/690 (17%), Positives = 280/690 (40%), Gaps = 50/690 (7%)
Query: 55 ERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKEL 114
E ++ LE V ++++ + L G + E +A+ ++ E + ++ ++ E
Sbjct: 474 ELLEEVLEGKQRVEEQLRLRERELTALKG-----ALKEEVASRDQEVEHVRQQYQRDTEQ 528
Query: 115 SKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILD 174
+RS + G L T +E + S+ Q + + T +
Sbjct: 529 LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQE 588
Query: 175 LQEKINEKDQIIEAKNKA--TTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEW 232
L + EK+++ E + E K+++ + QE ++AE
Sbjct: 589 LLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAER 648
Query: 233 KDEKQR-LLKDIE-SKDVRISSLE-EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
+ ++ +D E K + + +E + + LE ++ +L Q+ E+
Sbjct: 649 QSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAE 708
Query: 290 XXXXXLAKQ--SIEPSCEEKTEIEEKGSLEIANMTELTKKIELL----EHLNCQIRQTNK 343
L ++ ++E + E E ++ I + + K+ L E + ++R +
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 768
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSE--TLNQDTDKK 401
LE + + E +S ++GS ++++ + + ++L E TLN+ +++
Sbjct: 769 RLEAEKQQL--EEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 826
Query: 402 INKNEI-----AKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTLI-AQLQ 453
+ E+ A+LE + L++ D ++KE +D+ +D A+ +
Sbjct: 827 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 886
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV----KDLI-EKLKSA 508
+ Q + ++ + ++L+Q L + + K+L+ ++L+
Sbjct: 887 VADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL 946
Query: 509 EEQI-TQLNDEIDAAN--KNMIKVKSNHKLKLKQMQKTIDNFS-KVSDSNKEIVRLTEEL 564
E++ + + D A K + + S + +L + + T++ + +V+ ++ +L EL
Sbjct: 947 EQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL 1006
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLE 620
+LE +K +L+ D + R+ S+ ++K + ++E+ + + + E
Sbjct: 1007 MQERSARQDLECDKISLERQNKDLKT-RLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1065
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQL---QSDQVCSEIKSV-----HLEEQIDALS 672
+K L L++K E+ ++ D Q Q DQ+ +K++ EE+I+ L
Sbjct: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLEND 702
+K+ +E EQL IK LE D
Sbjct: 1126 GLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155
>AL354738-1|CAI16195.2| 1406|Homo sapiens chromosome 9 open reading
frame 39 protein.
Length = 1406
Score = 84.2 bits (199), Expect = 3e-15
Identities = 226/1183 (19%), Positives = 488/1183 (41%), Gaps = 104/1183 (8%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE----KLKSAEEQITQLNDEIDAANKN 525
TN + ++ V E+ KQ+ E KD V ++++ K++ E++ + L EI+ K
Sbjct: 136 TNPDLTQVVSLVVEREKQK--SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR 193
Query: 526 MIKVKSNHKLKLKQ---MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
I V + K+ ++K + S+ KE V+ EE + L K LEEE L
Sbjct: 194 KIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK--NLEEENKKLS 251
Query: 583 LHLVDY--DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
D D ++ + + + + + A+ + +L+E++K E+ + Q KY+
Sbjct: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----EVEVSQSKYNAL 306
Query: 639 --EVEDKLADISQLQSD--QVCSEIKSV-HLEEQIDALSASKKELALVIENLKLDKEQLY 693
++ +K ++ Q D V E++ + +L +Q +A + EL ++ L +D +++
Sbjct: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
+D+ + KL N + + T E M + ++ L ++ +EQ + +
Sbjct: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK----L 422
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
K+QE + E S S++ +E S + + + YLQEK K
Sbjct: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE----YLQEKLKIA 478
Query: 814 SEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEENQNLQISL 869
+E I ++ +R +++ + ++ ++ ++ L K+ EE Q L+ +
Sbjct: 479 NEKLSENISANKGFSRKSIMTSAEGKHKEPPVK---RSRSLSPKSSFTDSEELQKLRKAE 535
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDL 928
++ AL K+ D K + +L+ L++N + + + Q EI +
Sbjct: 536 RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
Query: 929 EIEFNTQIESAIRDKKVLNE-KYEK--NIEYVTQ---LEAQLQEYKNNIENLNMNVEELN 982
+ Q+ D V NE Y K N E + Q LE +L E K +I ++ELN
Sbjct: 596 KRADPQQLRQEDSDA-VWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELN 654
Query: 983 KMNLELIDKHVQKQ-----------QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ E ++ + + + + EQ + ++ +L LK ++ ++K
Sbjct: 655 RCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKR----SRK 710
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ M +S L Q E E+E++++ K D ++ N ELQ+ + E + +
Sbjct: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEF 1150
+ L+ + E N + E I PM + D +KV+ +
Sbjct: 771 VTSLR--RQVAEANALRNEN---EELINPMEKSHQSAD----RAKSEMATMKVRSGRYDC 821
Query: 1151 IQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ ++ ++AK N + +T + ++ ++ E +++ S E ++
Sbjct: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ 881
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ-------KTEHELRVQLS 1262
L + + E IS D + + ++ + Q + Q KT + +
Sbjct: 882 --TLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKN 939
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
A + +++ +Q S+ V E+ ++ Q ++ L+E+ + Q +
Sbjct: 940 AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI--TAQKSSSNIILLRERIISLQQQNSV 997
Query: 1323 LRSEIEDEKVA---FXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILNINEENAQLK 1378
L++ + +++ + +T Q+ K++ + + L +E+ K
Sbjct: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLEL--THQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
S +V +V L + ++L+ ++ K T LT+++ +
Sbjct: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKT 1117
Query: 1437 VRQQLVEYEKRIEDLTYEKESEL-AILRLKMH--ENANHYETMQKESEIERVKLIEELNV 1493
++ +L+ E+ I+++ +EK S + + +K H E+ + + ES ++++ L+
Sbjct: 1118 LKFELLAKEEHIKEM-HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK 1176
Query: 1494 KI---TESVSLNKQVA--ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
K+ TE S NK+V+ L + L V + ++ + + + E+ + ++T L + +
Sbjct: 1177 KVKTLTEECS-NKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRIS 1235
Query: 1549 ASSSKIQKHVSFASDTKQG---RDEQLDNTMNKELLDAVPRAE 1588
+ S + + + AS Q + EQ+ K LL A + E
Sbjct: 1236 ETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVE 1278
Score = 62.9 bits (146), Expect = 9e-09
Identities = 134/722 (18%), Positives = 284/722 (39%), Gaps = 37/722 (5%)
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
++ +++E++L ++ E Q + + + LQ++ D+ Q + +VE+ + A
Sbjct: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ Q++D + ++ L K+EI DL + + A+ ++ K
Sbjct: 158 KDRKVLEILQVKD--AKIQEFEQRESVL----KQEINDL-----VKRKIAVDEENAFLRK 206
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
++E + + + QE K+ E + N EE N++ ++ +++ +K T+ D +
Sbjct: 207 EFSDLE--KKFKDKSQEIKDTKECV-QNKEEQNRLVIKNLEEENKKLSTRCTDLLND-LE 262
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ K A L+++ A + + + V +SK + +L N + E+ +
Sbjct: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDM 322
Query: 1070 QLLDSKQHNEELQILVREQDD---QIKELKETKLTFEMNIPKT-EGMIISSTIEPMSDDA 1125
+ ++ +ELQ L ++ Q EL + M+ K T E +S
Sbjct: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ-SAKLNTELQECYTKIIQLETLNTE 1184
+ +++ +Q++ + +EQ +AKL +LQE + L +
Sbjct: 383 LYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAELWKQHL 1243
V ++ ++ L++ + +E + L + +S + +GF +
Sbjct: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAE 502
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK 1302
+ + K L + S +S+ Q L + + E + ++ L++ + +
Sbjct: 503 GKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
Query: 1303 EEHLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
+E L+ LQ Y V + Q E E K+ +L +
Sbjct: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLELKDSEIYQ 1418
+++ Q +N+ EE +LK V + E ++ E+K S +
Sbjct: 623 QELMIQK-MNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK 681
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
E Q+ E EN + + +++++ + E L+ + + ET +K
Sbjct: 682 NGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREK 741
Query: 1479 ESE--IERVKLIE----ELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E E I+ K +E EL VKI TE SL +QVAE N E N M+ + ++
Sbjct: 742 ELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQS 801
Query: 1529 QE 1530
+
Sbjct: 802 AD 803
Score = 59.7 bits (138), Expect = 9e-08
Identities = 73/354 (20%), Positives = 157/354 (44%), Gaps = 35/354 (9%)
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGT--IKD--LENDKEDIMN---KLQNYI 714
+ L++Q L +KK L ++ K E+L + D + ++ I L
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
Query: 715 QENMDLTDKLEKMSA-EKISELLAKINHE--EQSKIQTQFGIDAKIQERDLYIENIESEL 771
+E DL KLE S ++E +++ + + + +D ++++ ++N +EL
Sbjct: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+K S + L+ + E+ + K ++ E+ + I++ L R V +
Sbjct: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRM-----ERDITMKRHLIED--LKFRQKVNL 1161
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
+ ++ + L + L KK + L EE N ++S+ ++Q N V++ ++ +
Sbjct: 1162 ESNKSFSEML-------QNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
Query: 892 ESTKYQTQLRDLESNL--KRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+S K + + +DL+ L RI+ + K++++L ++ +E A + +
Sbjct: 1215 KS-KEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLA 1273
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQT 998
NEK E+ + T ++A +E +N++ + + EL KM N + K QT
Sbjct: 1274 NEKVEE---FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQT 1324
Score = 53.2 bits (122), Expect = 7e-06
Identities = 207/1153 (17%), Positives = 450/1153 (39%), Gaps = 107/1153 (9%)
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQR-LLKDIESKDVRISSLEEANKLLEAARFEIS-LEH 271
T +T++ + E + + K R +L+ ++ KD +I E+ +L+ EI+ L
Sbjct: 136 TNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQ---EINDLVK 192
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAK-QSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K+A + E K Q I+ + E EE+ L I N+ E KK+
Sbjct: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
Query: 331 --LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
+ LN + +E + T++K + + + + +RK + SK + Q
Sbjct: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTF---EDNLIEARKEVEVSQSKYNALSLQ 309
Query: 389 LSS---ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
LS+ E + +D D + + E+ +L+ + + + + +I + +
Sbjct: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQELNDEIKDVNVKDLI 502
+ + + +Q+ + T + + + +Q+QL Q+ + K L
Sbjct: 370 EDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK------LK 423
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKL+ ++ L E D + H+ L ++ + VS + EI L E
Sbjct: 424 EKLQESQGAPLPLPQESDPDYSAQVP----HRPSLSSLETLM-----VSQKS-EIEYLQE 473
Query: 563 ELHHLSQKVAE-LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
+L ++K++E + KG + ++ G+ E V + + T + + L
Sbjct: 474 KLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRK 533
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ + LQ K E D+L D + + +++ + ++EQ+ +
Sbjct: 534 AERKIENLEKALQLKSQE-NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSG-MTE 591
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKI 739
+ + + D +QL + D + + N+L + +EN +L ++KM+ E+ + EL I
Sbjct: 592 IRKIKRADPQQLR------QEDSDAVWNELAYFKRENQELM--IQKMNLEEELDELKVHI 643
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY------KSRICRLEESIAVMEDRRY 793
+ ++ + IQ A+ +E L+ + E+ + K + + + + +E+R
Sbjct: 644 SIDKAA-IQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLK 702
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S E+++ +L +E K + + D L + L + EK+L +I +K+++K
Sbjct: 703 SFEKRSRKL----KEGNKKLMK---ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
EN LQ+ +S+++ +L + + +E+ + + + R E
Sbjct: 756 -------ENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSE 808
Query: 914 HQTLIVQK-----KKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNI-EYVTQ------ 959
T+ V+ K + ++ + + S R VLN K N+ E +++
Sbjct: 809 MATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDV 868
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ-------QTQSPDYTEQYINEIN 1012
E+ + L + E ++ D QK+ QTQ + + Y+N
Sbjct: 869 SESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDG 928
Query: 1013 KL-NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
K K+ + +K Q S + V ++ + + + +++
Sbjct: 929 KTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERI 988
Query: 1072 LDSKQHNEELQILVREQDDQIKELKET--KLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +Q N LQ + + +KE KE KL + + TI+ + N+D
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKL-----NLD 1043
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
K++ E S+ +E S +Q T + +++ E+
Sbjct: 1044 LAGLRKEKEDLLKKLESSSEI---TSLAEENSQVTFPRIQ--VTSLSPSRSMDLEMKQLQ 1098
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ N+L + + T LL+ ++ + + + +I K+HL +
Sbjct: 1099 YKLKNATNELTKQSSNVKTLKFELLAKEEHIK-EMHEKISRMERDIT--MKRHLIEDLKF 1155
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
QK E +F + L V++ T+E +NK V+++ + N ++ +
Sbjct: 1156 RQKVNLESN---KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQM 1212
Query: 1310 QEKYADVINQIEI 1322
+K + + + ++
Sbjct: 1213 YQKSKEELEKKDL 1225
Score = 34.7 bits (76), Expect = 2.8
Identities = 72/386 (18%), Positives = 153/386 (39%), Gaps = 42/386 (10%)
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+L +L EL ++E + L +L+ N + ++S V E S A D++ EI
Sbjct: 108 ELSSLKEELALCQA-DKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEIL 166
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
++ K Q +F++ E L+ +++ D V+ + ++ + L+
Sbjct: 167 QV-KDAKIQ---EFEQRESVLKQEIN----------DLVKRKIAVDEENAFLRKEFSDLE 212
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
K +DK + +++ +E + Q ++ +E+E DL +
Sbjct: 213 KKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEEN-----------KKLSTRCTDLLNDL 261
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
+ ++ + ++ +E V +++K L+ QL K +E+
Sbjct: 262 EKLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTEL 317
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETM 1476
QK + T+ + + E +N+ +Q + + +L +L +L + + + E +
Sbjct: 318 IQKDMDITL-VRKELQELQNLYKQNSTHTAQQAELI----QQLQVLNMDTQKVLRNQEDV 372
Query: 1477 QKESEIERVKLIEELNV--KITES--VSLNKQVAELNKAL---EEEVAKTNEMQTALENQ 1529
I KL EL++ + T+S L + V L L E+E AK E +
Sbjct: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
Query: 1530 EIEIVTLNDEITNLQNMVRASSSKIQ 1555
+ + +D + Q R S S ++
Sbjct: 433 PLPLPQESDPDYSAQVPHRPSLSSLE 458
>AL354711-1|CAH72682.2| 1406|Homo sapiens chromosome 9 open reading
frame 39 protein.
Length = 1406
Score = 84.2 bits (199), Expect = 3e-15
Identities = 226/1183 (19%), Positives = 488/1183 (41%), Gaps = 104/1183 (8%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE----KLKSAEEQITQLNDEIDAANKN 525
TN + ++ V E+ KQ+ E KD V ++++ K++ E++ + L EI+ K
Sbjct: 136 TNPDLTQVVSLVVEREKQK--SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR 193
Query: 526 MIKVKSNHKLKLKQ---MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
I V + K+ ++K + S+ KE V+ EE + L K LEEE L
Sbjct: 194 KIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK--NLEEENKKLS 251
Query: 583 LHLVDY--DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
D D ++ + + + + + A+ + +L+E++K E+ + Q KY+
Sbjct: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----EVEVSQSKYNAL 306
Query: 639 --EVEDKLADISQLQSD--QVCSEIKSV-HLEEQIDALSASKKELALVIENLKLDKEQLY 693
++ +K ++ Q D V E++ + +L +Q +A + EL ++ L +D +++
Sbjct: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
+D+ + KL N + + T E M + ++ L ++ +EQ + +
Sbjct: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK----L 422
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
K+QE + E S S++ +E S + + + YLQEK K
Sbjct: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE----YLQEKLKIA 478
Query: 814 SEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEENQNLQISL 869
+E I ++ +R +++ + ++ ++ ++ L K+ EE Q L+ +
Sbjct: 479 NEKLSENISANKGFSRKSIMTSAEGKHKEPPVK---RSRSLSPKSSFTDSEELQKLRKAE 535
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDL 928
++ AL K+ D K + +L+ L++N + + + Q EI +
Sbjct: 536 RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
Query: 929 EIEFNTQIESAIRDKKVLNE-KYEK--NIEYVTQ---LEAQLQEYKNNIENLNMNVEELN 982
+ Q+ D V NE Y K N E + Q LE +L E K +I ++ELN
Sbjct: 596 KRADPQQLRQEDSDA-VWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELN 654
Query: 983 KMNLELIDKHVQKQ-----------QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ E ++ + + + + EQ + ++ +L LK ++ ++K
Sbjct: 655 RCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKR----SRK 710
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ M +S L Q E E+E++++ K D ++ N ELQ+ + E + +
Sbjct: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEF 1150
+ L+ + E N + E I PM + D +KV+ +
Sbjct: 771 VTSLR--RQVAEANALRNEN---EELINPMEKSHQSAD----RAKSEMATMKVRSGRYDC 821
Query: 1151 IQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ ++ ++AK N + +T + ++ ++ E +++ S E ++
Sbjct: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ 881
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ-------KTEHELRVQLS 1262
L + + E IS D + + ++ + Q + Q KT + +
Sbjct: 882 --TLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKN 939
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
A + +++ +Q S+ V E+ ++ Q ++ L+E+ + Q +
Sbjct: 940 AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI--TAQKSSSNIILLRERIISLQQQNSV 997
Query: 1323 LRSEIEDEKVA---FXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILNINEENAQLK 1378
L++ + +++ + +T Q+ K++ + + L +E+ K
Sbjct: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLEL--THQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
S +V +V L + ++L+ ++ K T LT+++ +
Sbjct: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKT 1117
Query: 1437 VRQQLVEYEKRIEDLTYEKESEL-AILRLKMH--ENANHYETMQKESEIERVKLIEELNV 1493
++ +L+ E+ I+++ +EK S + + +K H E+ + + ES ++++ L+
Sbjct: 1118 LKFELLAKEEHIKEM-HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK 1176
Query: 1494 KI---TESVSLNKQVA--ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
K+ TE S NK+V+ L + L V + ++ + + + E+ + ++T L + +
Sbjct: 1177 KVKTLTEECS-NKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRIS 1235
Query: 1549 ASSSKIQKHVSFASDTKQG---RDEQLDNTMNKELLDAVPRAE 1588
+ S + + + AS Q + EQ+ K LL A + E
Sbjct: 1236 ETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVE 1278
Score = 62.9 bits (146), Expect = 9e-09
Identities = 134/722 (18%), Positives = 284/722 (39%), Gaps = 37/722 (5%)
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
++ +++E++L ++ E Q + + + LQ++ D+ Q + +VE+ + A
Sbjct: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ Q++D + ++ L K+EI DL + + A+ ++ K
Sbjct: 158 KDRKVLEILQVKD--AKIQEFEQRESVL----KQEINDL-----VKRKIAVDEENAFLRK 206
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
++E + + + QE K+ E + N EE N++ ++ +++ +K T+ D +
Sbjct: 207 EFSDLE--KKFKDKSQEIKDTKECV-QNKEEQNRLVIKNLEEENKKLSTRCTDLLND-LE 262
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ K A L+++ A + + + V +SK + +L N + E+ +
Sbjct: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDM 322
Query: 1070 QLLDSKQHNEELQILVREQDD---QIKELKETKLTFEMNIPKT-EGMIISSTIEPMSDDA 1125
+ ++ +ELQ L ++ Q EL + M+ K T E +S
Sbjct: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ-SAKLNTELQECYTKIIQLETLNTE 1184
+ +++ +Q++ + +EQ +AKL +LQE + L +
Sbjct: 383 LYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAELWKQHL 1243
V ++ ++ L++ + +E + L + +S + +GF +
Sbjct: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAE 502
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK 1302
+ + K L + S +S+ Q L + + E + ++ L++ + +
Sbjct: 503 GKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
Query: 1303 EEHLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
+E L+ LQ Y V + Q E E K+ +L +
Sbjct: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLELKDSEIYQ 1418
+++ Q +N+ EE +LK V + E ++ E+K S +
Sbjct: 623 QELMIQK-MNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK 681
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
E Q+ E EN + + +++++ + E L+ + + ET +K
Sbjct: 682 NGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREK 741
Query: 1479 ESE--IERVKLIE----ELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E E I+ K +E EL VKI TE SL +QVAE N E N M+ + ++
Sbjct: 742 ELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQS 801
Query: 1529 QE 1530
+
Sbjct: 802 AD 803
Score = 59.7 bits (138), Expect = 9e-08
Identities = 73/354 (20%), Positives = 157/354 (44%), Gaps = 35/354 (9%)
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGT--IKD--LENDKEDIMN---KLQNYI 714
+ L++Q L +KK L ++ K E+L + D + ++ I L
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
Query: 715 QENMDLTDKLEKMSA-EKISELLAKINHE--EQSKIQTQFGIDAKIQERDLYIENIESEL 771
+E DL KLE S ++E +++ + + + +D ++++ ++N +EL
Sbjct: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+K S + L+ + E+ + K ++ E+ + I++ L R V +
Sbjct: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRM-----ERDITMKRHLIED--LKFRQKVNL 1161
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
+ ++ + L + L KK + L EE N ++S+ ++Q N V++ ++ +
Sbjct: 1162 ESNKSFSEML-------QNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
Query: 892 ESTKYQTQLRDLESNL--KRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+S K + + +DL+ L RI+ + K++++L ++ +E A + +
Sbjct: 1215 KS-KEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLA 1273
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQT 998
NEK E+ + T ++A +E +N++ + + EL KM N + K QT
Sbjct: 1274 NEKVEE---FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQT 1324
Score = 53.2 bits (122), Expect = 7e-06
Identities = 207/1153 (17%), Positives = 450/1153 (39%), Gaps = 107/1153 (9%)
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQR-LLKDIESKDVRISSLEEANKLLEAARFEIS-LEH 271
T +T++ + E + + K R +L+ ++ KD +I E+ +L+ EI+ L
Sbjct: 136 TNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQ---EINDLVK 192
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAK-QSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K+A + E K Q I+ + E EE+ L I N+ E KK+
Sbjct: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
Query: 331 --LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
+ LN + +E + T++K + + + + +RK + SK + Q
Sbjct: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTF---EDNLIEARKEVEVSQSKYNALSLQ 309
Query: 389 LSS---ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
LS+ E + +D D + + E+ +L+ + + + + +I + +
Sbjct: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQELNDEIKDVNVKDLI 502
+ + + +Q+ + T + + + +Q+QL Q+ + K L
Sbjct: 370 EDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK------LK 423
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKL+ ++ L E D + H+ L ++ + VS + EI L E
Sbjct: 424 EKLQESQGAPLPLPQESDPDYSAQVP----HRPSLSSLETLM-----VSQKS-EIEYLQE 473
Query: 563 ELHHLSQKVAE-LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
+L ++K++E + KG + ++ G+ E V + + T + + L
Sbjct: 474 KLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRK 533
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ + LQ K E D+L D + + +++ + ++EQ+ +
Sbjct: 534 AERKIENLEKALQLKSQE-NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSG-MTE 591
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKI 739
+ + + D +QL + D + + N+L + +EN +L ++KM+ E+ + EL I
Sbjct: 592 IRKIKRADPQQLR------QEDSDAVWNELAYFKRENQELM--IQKMNLEEELDELKVHI 643
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY------KSRICRLEESIAVMEDRRY 793
+ ++ + IQ A+ +E L+ + E+ + K + + + + +E+R
Sbjct: 644 SIDKAA-IQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLK 702
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S E+++ +L +E K + + D L + L + EK+L +I +K+++K
Sbjct: 703 SFEKRSRKL----KEGNKKLMK---ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
EN LQ+ +S+++ +L + + +E+ + + + R E
Sbjct: 756 -------ENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSE 808
Query: 914 HQTLIVQK-----KKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNI-EYVTQ------ 959
T+ V+ K + ++ + + S R VLN K N+ E +++
Sbjct: 809 MATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDV 868
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ-------QTQSPDYTEQYINEIN 1012
E+ + L + E ++ D QK+ QTQ + + Y+N
Sbjct: 869 SESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDG 928
Query: 1013 KL-NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
K K+ + +K Q S + V ++ + + + +++
Sbjct: 929 KTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERI 988
Query: 1072 LDSKQHNEELQILVREQDDQIKELKET--KLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +Q N LQ + + +KE KE KL + + TI+ + N+D
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKL-----NLD 1043
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
K++ E S+ +E S +Q T + +++ E+
Sbjct: 1044 LAGLRKEKEDLLKKLESSSEI---TSLAEENSQVTFPRIQ--VTSLSPSRSMDLEMKQLQ 1098
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ N+L + + T LL+ ++ + + + +I K+HL +
Sbjct: 1099 YKLKNATNELTKQSSNVKTLKFELLAKEEHIK-EMHEKISRMERDIT--MKRHLIEDLKF 1155
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
QK E +F + L V++ T+E +NK V+++ + N ++ +
Sbjct: 1156 RQKVNLESN---KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQM 1212
Query: 1310 QEKYADVINQIEI 1322
+K + + + ++
Sbjct: 1213 YQKSKEELEKKDL 1225
Score = 34.7 bits (76), Expect = 2.8
Identities = 72/386 (18%), Positives = 153/386 (39%), Gaps = 42/386 (10%)
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+L +L EL ++E + L +L+ N + ++S V E S A D++ EI
Sbjct: 108 ELSSLKEELALCQA-DKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEIL 166
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
++ K Q +F++ E L+ +++ D V+ + ++ + L+
Sbjct: 167 QV-KDAKIQ---EFEQRESVLKQEIN----------DLVKRKIAVDEENAFLRKEFSDLE 212
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
K +DK + +++ +E + Q ++ +E+E DL +
Sbjct: 213 KKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEEN-----------KKLSTRCTDLLNDL 261
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
+ ++ + ++ +E V +++K L+ QL K +E+
Sbjct: 262 EKLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTEL 317
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETM 1476
QK + T+ + + E +N+ +Q + + +L +L +L + + + E +
Sbjct: 318 IQKDMDITL-VRKELQELQNLYKQNSTHTAQQAELI----QQLQVLNMDTQKVLRNQEDV 372
Query: 1477 QKESEIERVKLIEELNV--KITES--VSLNKQVAELNKAL---EEEVAKTNEMQTALENQ 1529
I KL EL++ + T+S L + V L L E+E AK E +
Sbjct: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
Query: 1530 EIEIVTLNDEITNLQNMVRASSSKIQ 1555
+ + +D + Q R S S ++
Sbjct: 433 PLPLPQESDPDYSAQVPHRPSLSSLE 458
>AL162725-3|CAH70424.1| 1406|Homo sapiens chromosome 9 open reading
frame 39 protein.
Length = 1406
Score = 84.2 bits (199), Expect = 3e-15
Identities = 226/1183 (19%), Positives = 488/1183 (41%), Gaps = 104/1183 (8%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE----KLKSAEEQITQLNDEIDAANKN 525
TN + ++ V E+ KQ+ E KD V ++++ K++ E++ + L EI+ K
Sbjct: 136 TNPDLTQVVSLVVEREKQK--SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR 193
Query: 526 MIKVKSNHKLKLKQ---MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
I V + K+ ++K + S+ KE V+ EE + L K LEEE L
Sbjct: 194 KIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK--NLEEENKKLS 251
Query: 583 LHLVDY--DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
D D ++ + + + + + A+ + +L+E++K E+ + Q KY+
Sbjct: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----EVEVSQSKYNAL 306
Query: 639 --EVEDKLADISQLQSD--QVCSEIKSV-HLEEQIDALSASKKELALVIENLKLDKEQLY 693
++ +K ++ Q D V E++ + +L +Q +A + EL ++ L +D +++
Sbjct: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
+D+ + KL N + + T E M + ++ L ++ +EQ + +
Sbjct: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK----L 422
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
K+QE + E S S++ +E S + + + YLQEK K
Sbjct: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE----YLQEKLKIA 478
Query: 814 SEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEENQNLQISL 869
+E I ++ +R +++ + ++ ++ ++ L K+ EE Q L+ +
Sbjct: 479 NEKLSENISANKGFSRKSIMTSAEGKHKEPPVK---RSRSLSPKSSFTDSEELQKLRKAE 535
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDL 928
++ AL K+ D K + +L+ L++N + + + Q EI +
Sbjct: 536 RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
Query: 929 EIEFNTQIESAIRDKKVLNE-KYEK--NIEYVTQ---LEAQLQEYKNNIENLNMNVEELN 982
+ Q+ D V NE Y K N E + Q LE +L E K +I ++ELN
Sbjct: 596 KRADPQQLRQEDSDA-VWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELN 654
Query: 983 KMNLELIDKHVQKQ-----------QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ E ++ + + + + EQ + ++ +L LK ++ ++K
Sbjct: 655 RCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKR----SRK 710
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ M +S L Q E E+E++++ K D ++ N ELQ+ + E + +
Sbjct: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEF 1150
+ L+ + E N + E I PM + D +KV+ +
Sbjct: 771 VTSLR--RQVAEANALRNEN---EELINPMEKSHQSAD----RAKSEMATMKVRSGRYDC 821
Query: 1151 IQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ ++ ++AK N + +T + ++ ++ E +++ S E ++
Sbjct: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ 881
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ-------KTEHELRVQLS 1262
L + + E IS D + + ++ + Q + Q KT + +
Sbjct: 882 --TLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKN 939
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
A + +++ +Q S+ V E+ ++ Q ++ L+E+ + Q +
Sbjct: 940 AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI--TAQKSSSNIILLRERIISLQQQNSV 997
Query: 1323 LRSEIEDEKVA---FXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILNINEENAQLK 1378
L++ + +++ + +T Q+ K++ + + L +E+ K
Sbjct: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLEL--THQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
S +V +V L + ++L+ ++ K T LT+++ +
Sbjct: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKT 1117
Query: 1437 VRQQLVEYEKRIEDLTYEKESEL-AILRLKMH--ENANHYETMQKESEIERVKLIEELNV 1493
++ +L+ E+ I+++ +EK S + + +K H E+ + + ES ++++ L+
Sbjct: 1118 LKFELLAKEEHIKEM-HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK 1176
Query: 1494 KI---TESVSLNKQVA--ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
K+ TE S NK+V+ L + L V + ++ + + + E+ + ++T L + +
Sbjct: 1177 KVKTLTEECS-NKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRIS 1235
Query: 1549 ASSSKIQKHVSFASDTKQG---RDEQLDNTMNKELLDAVPRAE 1588
+ S + + + AS Q + EQ+ K LL A + E
Sbjct: 1236 ETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVE 1278
Score = 62.9 bits (146), Expect = 9e-09
Identities = 134/722 (18%), Positives = 284/722 (39%), Gaps = 37/722 (5%)
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
++ +++E++L ++ E Q + + + LQ++ D+ Q + +VE+ + A
Sbjct: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ Q++D + ++ L K+EI DL + + A+ ++ K
Sbjct: 158 KDRKVLEILQVKD--AKIQEFEQRESVL----KQEINDL-----VKRKIAVDEENAFLRK 206
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
++E + + + QE K+ E + N EE N++ ++ +++ +K T+ D +
Sbjct: 207 EFSDLE--KKFKDKSQEIKDTKECV-QNKEEQNRLVIKNLEEENKKLSTRCTDLLND-LE 262
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ K A L+++ A + + + V +SK + +L N + E+ +
Sbjct: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDM 322
Query: 1070 QLLDSKQHNEELQILVREQDD---QIKELKETKLTFEMNIPKT-EGMIISSTIEPMSDDA 1125
+ ++ +ELQ L ++ Q EL + M+ K T E +S
Sbjct: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ-SAKLNTELQECYTKIIQLETLNTE 1184
+ +++ +Q++ + +EQ +AKL +LQE + L +
Sbjct: 383 LYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAELWKQHL 1243
V ++ ++ L++ + +E + L + +S + +GF +
Sbjct: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAE 502
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK 1302
+ + K L + S +S+ Q L + + E + ++ L++ + +
Sbjct: 503 GKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
Query: 1303 EEHLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
+E L+ LQ Y V + Q E E K+ +L +
Sbjct: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLELKDSEIYQ 1418
+++ Q +N+ EE +LK V + E ++ E+K S +
Sbjct: 623 QELMIQK-MNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK 681
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
E Q+ E EN + + +++++ + E L+ + + ET +K
Sbjct: 682 NGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREK 741
Query: 1479 ESE--IERVKLIE----ELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E E I+ K +E EL VKI TE SL +QVAE N E N M+ + ++
Sbjct: 742 ELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQS 801
Query: 1529 QE 1530
+
Sbjct: 802 AD 803
Score = 59.7 bits (138), Expect = 9e-08
Identities = 73/354 (20%), Positives = 157/354 (44%), Gaps = 35/354 (9%)
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGT--IKD--LENDKEDIMN---KLQNYI 714
+ L++Q L +KK L ++ K E+L + D + ++ I L
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
Query: 715 QENMDLTDKLEKMSA-EKISELLAKINHE--EQSKIQTQFGIDAKIQERDLYIENIESEL 771
+E DL KLE S ++E +++ + + + +D ++++ ++N +EL
Sbjct: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+K S + L+ + E+ + K ++ E+ + I++ L R V +
Sbjct: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRM-----ERDITMKRHLIED--LKFRQKVNL 1161
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
+ ++ + L + L KK + L EE N ++S+ ++Q N V++ ++ +
Sbjct: 1162 ESNKSFSEML-------QNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
Query: 892 ESTKYQTQLRDLESNL--KRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+S K + + +DL+ L RI+ + K++++L ++ +E A + +
Sbjct: 1215 KS-KEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLA 1273
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQT 998
NEK E+ + T ++A +E +N++ + + EL KM N + K QT
Sbjct: 1274 NEKVEE---FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQT 1324
Score = 53.2 bits (122), Expect = 7e-06
Identities = 207/1153 (17%), Positives = 450/1153 (39%), Gaps = 107/1153 (9%)
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQR-LLKDIESKDVRISSLEEANKLLEAARFEIS-LEH 271
T +T++ + E + + K R +L+ ++ KD +I E+ +L+ EI+ L
Sbjct: 136 TNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQ---EINDLVK 192
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAK-QSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K+A + E K Q I+ + E EE+ L I N+ E KK+
Sbjct: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
Query: 331 --LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
+ LN + +E + T++K + + + + +RK + SK + Q
Sbjct: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTF---EDNLIEARKEVEVSQSKYNALSLQ 309
Query: 389 LSS---ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
LS+ E + +D D + + E+ +L+ + + + + +I + +
Sbjct: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQELNDEIKDVNVKDLI 502
+ + + +Q+ + T + + + +Q+QL Q+ + K L
Sbjct: 370 EDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK------LK 423
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKL+ ++ L E D + H+ L ++ + VS + EI L E
Sbjct: 424 EKLQESQGAPLPLPQESDPDYSAQVP----HRPSLSSLETLM-----VSQKS-EIEYLQE 473
Query: 563 ELHHLSQKVAE-LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
+L ++K++E + KG + ++ G+ E V + + T + + L
Sbjct: 474 KLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRK 533
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ + LQ K E D+L D + + +++ + ++EQ+ +
Sbjct: 534 AERKIENLEKALQLKSQE-NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSG-MTE 591
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKI 739
+ + + D +QL + D + + N+L + +EN +L ++KM+ E+ + EL I
Sbjct: 592 IRKIKRADPQQLR------QEDSDAVWNELAYFKRENQELM--IQKMNLEEELDELKVHI 643
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY------KSRICRLEESIAVMEDRRY 793
+ ++ + IQ A+ +E L+ + E+ + K + + + + +E+R
Sbjct: 644 SIDKAA-IQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLK 702
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S E+++ +L +E K + + D L + L + EK+L +I +K+++K
Sbjct: 703 SFEKRSRKL----KEGNKKLMK---ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
EN LQ+ +S+++ +L + + +E+ + + + R E
Sbjct: 756 -------ENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSE 808
Query: 914 HQTLIVQK-----KKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNI-EYVTQ------ 959
T+ V+ K + ++ + + S R VLN K N+ E +++
Sbjct: 809 MATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDV 868
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ-------QTQSPDYTEQYINEIN 1012
E+ + L + E ++ D QK+ QTQ + + Y+N
Sbjct: 869 SESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDG 928
Query: 1013 KL-NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
K K+ + +K Q S + V ++ + + + +++
Sbjct: 929 KTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERI 988
Query: 1072 LDSKQHNEELQILVREQDDQIKELKET--KLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +Q N LQ + + +KE KE KL + + TI+ + N+D
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKL-----NLD 1043
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
K++ E S+ +E S +Q T + +++ E+
Sbjct: 1044 LAGLRKEKEDLLKKLESSSEI---TSLAEENSQVTFPRIQ--VTSLSPSRSMDLEMKQLQ 1098
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ N+L + + T LL+ ++ + + + +I K+HL +
Sbjct: 1099 YKLKNATNELTKQSSNVKTLKFELLAKEEHIK-EMHEKISRMERDIT--MKRHLIEDLKF 1155
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
QK E +F + L V++ T+E +NK V+++ + N ++ +
Sbjct: 1156 RQKVNLESN---KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQM 1212
Query: 1310 QEKYADVINQIEI 1322
+K + + + ++
Sbjct: 1213 YQKSKEELEKKDL 1225
Score = 34.7 bits (76), Expect = 2.8
Identities = 72/386 (18%), Positives = 153/386 (39%), Gaps = 42/386 (10%)
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+L +L EL ++E + L +L+ N + ++S V E S A D++ EI
Sbjct: 108 ELSSLKEELALCQA-DKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEIL 166
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
++ K Q +F++ E L+ +++ D V+ + ++ + L+
Sbjct: 167 QV-KDAKIQ---EFEQRESVLKQEIN----------DLVKRKIAVDEENAFLRKEFSDLE 212
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
K +DK + +++ +E + Q ++ +E+E DL +
Sbjct: 213 KKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEEN-----------KKLSTRCTDLLNDL 261
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
+ ++ + ++ +E V +++K L+ QL K +E+
Sbjct: 262 EKLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTEL 317
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETM 1476
QK + T+ + + E +N+ +Q + + +L +L +L + + + E +
Sbjct: 318 IQKDMDITL-VRKELQELQNLYKQNSTHTAQQAELI----QQLQVLNMDTQKVLRNQEDV 372
Query: 1477 QKESEIERVKLIEELNV--KITES--VSLNKQVAELNKAL---EEEVAKTNEMQTALENQ 1529
I KL EL++ + T+S L + V L L E+E AK E +
Sbjct: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
Query: 1530 EIEIVTLNDEITNLQNMVRASSSKIQ 1555
+ + +D + Q R S S ++
Sbjct: 433 PLPLPQESDPDYSAQVPHRPSLSSLE 458
>AL133214-3|CAH70743.2| 1406|Homo sapiens chromosome 9 open reading
frame 39 protein.
Length = 1406
Score = 84.2 bits (199), Expect = 3e-15
Identities = 226/1183 (19%), Positives = 488/1183 (41%), Gaps = 104/1183 (8%)
Query: 470 TNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIE----KLKSAEEQITQLNDEIDAANKN 525
TN + ++ V E+ KQ+ E KD V ++++ K++ E++ + L EI+ K
Sbjct: 136 TNPDLTQVVSLVVEREKQK--SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR 193
Query: 526 MIKVKSNHKLKLKQ---MQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQ 582
I V + K+ ++K + S+ KE V+ EE + L K LEEE L
Sbjct: 194 KIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK--NLEEENKKLS 251
Query: 583 LHLVDY--DSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
D D ++ + + + + + A+ + +L+E++K E+ + Q KY+
Sbjct: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----EVEVSQSKYNAL 306
Query: 639 --EVEDKLADISQLQSD--QVCSEIKSV-HLEEQIDALSASKKELALVIENLKLDKEQLY 693
++ +K ++ Q D V E++ + +L +Q +A + EL ++ L +D +++
Sbjct: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
Query: 694 GTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGI 753
+D+ + KL N + + T E M + ++ L ++ +EQ + +
Sbjct: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK----L 422
Query: 754 DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAY 813
K+QE + E S S++ +E S + + + YLQEK K
Sbjct: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE----YLQEKLKIA 478
Query: 814 SEY---TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEENQNLQISL 869
+E I ++ +R +++ + ++ ++ ++ L K+ EE Q L+ +
Sbjct: 479 NEKLSENISANKGFSRKSIMTSAEGKHKEPPVK---RSRSLSPKSSFTDSEELQKLRKAE 535
Query: 870 SDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE-HQTLIVQKKKEIEDL 928
++ AL K+ D K + +L+ L++N + + + Q EI +
Sbjct: 536 RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
Query: 929 EIEFNTQIESAIRDKKVLNE-KYEK--NIEYVTQ---LEAQLQEYKNNIENLNMNVEELN 982
+ Q+ D V NE Y K N E + Q LE +L E K +I ++ELN
Sbjct: 596 KRADPQQLRQEDSDA-VWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELN 654
Query: 983 KMNLELIDKHVQKQ-----------QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ E ++ + + + + EQ + ++ +L LK ++ ++K
Sbjct: 655 RCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKR----SRK 710
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQ 1091
+ M +S L Q E E+E++++ K D ++ N ELQ+ + E + +
Sbjct: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE-EEEF 1150
+ L+ + E N + E I PM + D +KV+ +
Sbjct: 771 VTSLR--RQVAEANALRNEN---EELINPMEKSHQSAD----RAKSEMATMKVRSGRYDC 821
Query: 1151 IQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELTGHDVVNQEQINQLKSKLEQLNTE 1209
+ ++ ++AK N + +T + ++ ++ E +++ S E ++
Sbjct: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ 881
Query: 1210 NDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQ-------KTEHELRVQLS 1262
L + + E IS D + + ++ + Q + Q KT + +
Sbjct: 882 --TLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKN 939
Query: 1263 AFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
A + +++ +Q S+ V E+ ++ Q ++ L+E+ + Q +
Sbjct: 940 AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI--TAQKSSSNIILLRERIISLQQQNSV 997
Query: 1323 LRSEIEDEKVA---FXXXXXXXXXXXXXXXXDLRTENQSYKQMQ-EQSILNINEENAQLK 1378
L++ + +++ + +T Q+ K++ + + L +E+ K
Sbjct: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Query: 1379 KSSXXXXXXXXXXXXRVNDAEAKVLEL--THQLELKDSEIYQKTHEYTITLTQRNDEFEN 1436
S +V +V L + ++L+ ++ K T LT+++ +
Sbjct: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKT 1117
Query: 1437 VRQQLVEYEKRIEDLTYEKESEL-AILRLKMH--ENANHYETMQKESEIERVKLIEELNV 1493
++ +L+ E+ I+++ +EK S + + +K H E+ + + ES ++++ L+
Sbjct: 1118 LKFELLAKEEHIKEM-HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK 1176
Query: 1494 KI---TESVSLNKQVA--ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
K+ TE S NK+V+ L + L V + ++ + + + E+ + ++T L + +
Sbjct: 1177 KVKTLTEECS-NKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRIS 1235
Query: 1549 ASSSKIQKHVSFASDTKQG---RDEQLDNTMNKELLDAVPRAE 1588
+ S + + + AS Q + EQ+ K LL A + E
Sbjct: 1236 ETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVE 1278
Score = 62.9 bits (146), Expect = 9e-09
Identities = 134/722 (18%), Positives = 284/722 (39%), Gaps = 37/722 (5%)
Query: 830 LMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLA 889
++ +++E++L ++ E Q + + + LQ++ D+ Q + +VE+ + A
Sbjct: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
Query: 890 ESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEK 949
+ Q++D + ++ L K+EI DL + + A+ ++ K
Sbjct: 158 KDRKVLEILQVKD--AKIQEFEQRESVL----KQEINDL-----VKRKIAVDEENAFLRK 206
Query: 950 YEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYIN 1009
++E + + + QE K+ E + N EE N++ ++ +++ +K T+ D +
Sbjct: 207 EFSDLE--KKFKDKSQEIKDTKECV-QNKEEQNRLVIKNLEEENKKLSTRCTDLLND-LE 262
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSK 1069
++ K A L+++ A + + + V +SK + +L N + E+ +
Sbjct: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDM 322
Query: 1070 QLLDSKQHNEELQILVREQDD---QIKELKETKLTFEMNIPKT-EGMIISSTIEPMSDDA 1125
+ ++ +ELQ L ++ Q EL + M+ K T E +S
Sbjct: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
Query: 1126 NNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ-SAKLNTELQECYTKIIQLETLNTE 1184
+ +++ +Q++ + +EQ +AKL +LQE + L +
Sbjct: 383 LYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
Query: 1185 LTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRGFEIAELWKQHL 1243
V ++ ++ L++ + +E + L + +S + +GF +
Sbjct: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAE 502
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDK 1302
+ + K L + S +S+ Q L + + E + ++ L++ + +
Sbjct: 503 GKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
Query: 1303 EEHLRNLQEKYADV---INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSY 1359
+E L+ LQ Y V + Q E E K+ +L +
Sbjct: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
Query: 1360 KQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVND-AEAKVLELTHQLELKDSEIYQ 1418
+++ Q +N+ EE +LK V + E ++ E+K S +
Sbjct: 623 QELMIQK-MNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK 681
Query: 1419 KTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQK 1478
E Q+ E EN + + +++++ + E L+ + + ET +K
Sbjct: 682 NGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREK 741
Query: 1479 ESE--IERVKLIE----ELNVKI----TESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
E E I+ K +E EL VKI TE SL +QVAE N E N M+ + ++
Sbjct: 742 ELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQS 801
Query: 1529 QE 1530
+
Sbjct: 802 AD 803
Score = 59.7 bits (138), Expect = 9e-08
Identities = 73/354 (20%), Positives = 157/354 (44%), Gaps = 35/354 (9%)
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGT--IKD--LENDKEDIMN---KLQNYI 714
+ L++Q L +KK L ++ K E+L + D + ++ I L
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
Query: 715 QENMDLTDKLEKMSA-EKISELLAKINHE--EQSKIQTQFGIDAKIQERDLYIENIESEL 771
+E DL KLE S ++E +++ + + + +D ++++ ++N +EL
Sbjct: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
Query: 772 SKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLM 831
+K S + L+ + E+ + K ++ E+ + I++ L R V +
Sbjct: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRM-----ERDITMKRHLIED--LKFRQKVNL 1161
Query: 832 DHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAES 891
+ ++ + L + L KK + L EE N ++S+ ++Q N V++ ++ +
Sbjct: 1162 ESNKSFSEML-------QNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
Query: 892 ESTKYQTQLRDLESNL--KRITHEHQTLI---VQKKKEIEDLEIEFNTQIESAIRDKKVL 946
+S K + + +DL+ L RI+ + K++++L ++ +E A + +
Sbjct: 1215 KS-KEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLA 1273
Query: 947 NEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQT 998
NEK E+ + T ++A +E +N++ + + EL KM N + K QT
Sbjct: 1274 NEKVEE---FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQT 1324
Score = 53.2 bits (122), Expect = 7e-06
Identities = 207/1153 (17%), Positives = 450/1153 (39%), Gaps = 107/1153 (9%)
Query: 214 TKQQMTKMQENFIAMEAEWKDEKQR-LLKDIESKDVRISSLEEANKLLEAARFEIS-LEH 271
T +T++ + E + + K R +L+ ++ KD +I E+ +L+ EI+ L
Sbjct: 136 TNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQ---EINDLVK 192
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAK-QSIEPSCEEKTEIEEKGSLEIANMTELTKKIEL 330
K+A + E K Q I+ + E EE+ L I N+ E KK+
Sbjct: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
Query: 331 --LEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQ 388
+ LN + +E + T++K + + + + +RK + SK + Q
Sbjct: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTF---EDNLIEARKEVEVSQSKYNALSLQ 309
Query: 389 LSS---ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGK 445
LS+ E + +D D + + E+ +L+ + + + + +I + +
Sbjct: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
Query: 446 DTLIAQLQLEHQQHMEGPSLIHVGTNTEDV---NEIAKVQEQLKQELNDEIKDVNVKDLI 502
+ + + +Q+ + T + + + +Q+QL Q+ + K L
Sbjct: 370 EDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK------LK 423
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE 562
EKL+ ++ L E D + H+ L ++ + VS + EI L E
Sbjct: 424 EKLQESQGAPLPLPQESDPDYSAQVP----HRPSLSSLETLM-----VSQKS-EIEYLQE 473
Query: 563 ELHHLSQKVAE-LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLES 621
+L ++K++E + KG + ++ G+ E V + + T + + L
Sbjct: 474 KLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRK 533
Query: 622 QKFDLVQELHILQQKYDEVEDKLADISQLQSDQV-CSEIKSVHLEEQIDALSASKKELAL 680
+ + LQ K E D+L D + + +++ + ++EQ+ +
Sbjct: 534 AERKIENLEKALQLKSQE-NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSG-MTE 591
Query: 681 VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK-ISELLAKI 739
+ + + D +QL + D + + N+L + +EN +L ++KM+ E+ + EL I
Sbjct: 592 IRKIKRADPQQLR------QEDSDAVWNELAYFKRENQELM--IQKMNLEEELDELKVHI 643
Query: 740 NHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY------KSRICRLEESIAVMEDRRY 793
+ ++ + IQ A+ +E L+ + E+ + K + + + + +E+R
Sbjct: 644 SIDKAA-IQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLK 702
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S E+++ +L +E K + + D L + L + EK+L +I +K+++K
Sbjct: 703 SFEKRSRKL----KEGNKKLMK---ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
EN LQ+ +S+++ +L + + +E+ + + + R E
Sbjct: 756 -------ENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSE 808
Query: 914 HQTLIVQK-----KKEIEDLEIEFNTQIESAIRDKKVLNE--KYEKNI-EYVTQ------ 959
T+ V+ K + ++ + + S R VLN K N+ E +++
Sbjct: 809 MATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDV 868
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ-------QTQSPDYTEQYINEIN 1012
E+ + L + E ++ D QK+ QTQ + + Y+N
Sbjct: 869 SESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDG 928
Query: 1013 KL-NALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL 1071
K K+ + +K Q S + V ++ + + + +++
Sbjct: 929 KTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERI 988
Query: 1072 LDSKQHNEELQILVREQDDQIKELKET--KLTFEMNIPKTEGMIISSTIEPMSDDANNVD 1129
+ +Q N LQ + + +KE KE KL + + TI+ + N+D
Sbjct: 989 ISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKL-----NLD 1043
Query: 1130 XXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD 1189
K++ E S+ +E S +Q T + +++ E+
Sbjct: 1044 LAGLRKEKEDLLKKLESSSEI---TSLAEENSQVTFPRIQ--VTSLSPSRSMDLEMKQLQ 1098
Query: 1190 VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD 1249
+ N+L + + T LL+ ++ + + + +I K+HL +
Sbjct: 1099 YKLKNATNELTKQSSNVKTLKFELLAKEEHIK-EMHEKISRMERDIT--MKRHLIEDLKF 1155
Query: 1250 FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNL 1309
QK E +F + L V++ T+E +NK V+++ + N ++ +
Sbjct: 1156 RQKVNLESN---KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQM 1212
Query: 1310 QEKYADVINQIEI 1322
+K + + + ++
Sbjct: 1213 YQKSKEELEKKDL 1225
Score = 34.7 bits (76), Expect = 2.8
Identities = 72/386 (18%), Positives = 153/386 (39%), Gaps = 42/386 (10%)
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIA 1236
+L +L EL ++E + L +L+ N + ++S V E S A D++ EI
Sbjct: 108 ELSSLKEELALCQA-DKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEIL 166
Query: 1237 ELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
++ K Q +F++ E L+ +++ D V+ + ++ + L+
Sbjct: 167 QV-KDAKIQ---EFEQRESVLKQEIN----------DLVKRKIAVDEENAFLRKEFSDLE 212
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
K +DK + +++ +E + Q ++ +E+E DL +
Sbjct: 213 KKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEEN-----------KKLSTRCTDLLNDL 261
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI 1416
+ ++ + ++ +E V +++K L+ QL K +E+
Sbjct: 262 EKLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTEL 317
Query: 1417 YQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETM 1476
QK + T+ + + E +N+ +Q + + +L +L +L + + + E +
Sbjct: 318 IQKDMDITL-VRKELQELQNLYKQNSTHTAQQAELI----QQLQVLNMDTQKVLRNQEDV 372
Query: 1477 QKESEIERVKLIEELNV--KITES--VSLNKQVAELNKAL---EEEVAKTNEMQTALENQ 1529
I KL EL++ + T+S L + V L L E+E AK E +
Sbjct: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
Query: 1530 EIEIVTLNDEITNLQNMVRASSSKIQ 1555
+ + +D + Q R S S ++
Sbjct: 433 PLPLPQESDPDYSAQVPHRPSLSSLE 458
>AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens
cDNA FLJ43937 fis, clone TESTI4013924. ).
Length = 623
Score = 84.2 bits (199), Expect = 3e-15
Identities = 124/511 (24%), Positives = 238/511 (46%), Gaps = 58/511 (11%)
Query: 477 EIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLK 536
E K +E LK + + I+ +K +KL+ A E+ ++ DE+ N ++K K K +
Sbjct: 110 EAEKRREDLKLKAQESIRQWKLKH--KKLERALEKQSETVDELTGKNNQILKEKDELKTQ 167
Query: 537 LKQMQKTIDNFSK-VSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVD-YDSGRMI 594
L + I+N K ++D + EELH +K+ +++ + +L+L + + D+ +
Sbjct: 168 LYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRL 227
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSD- 653
ES++ KK ++++ + KA LE + +L + + K E+++ + D+S +++D
Sbjct: 228 ESEL-KKQSKIQSQMKVE-KAH--LEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADL 283
Query: 654 --QVCSE--IKSVHLEEQIDALSASK---KELALVIENLKLDKEQLYGTIKDLENDKEDI 706
++ E K L++ D + +K +E A +I LKL+++ +KDL + + +
Sbjct: 284 ANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV 343
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
K + IQE M K EK AE L + EE++ AKI
Sbjct: 344 KTKHEQNIQELMKHFKK-EKSEAENHIRTLKAESLEEKNM--------AKIH-------- 386
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN- 825
+L K KS+ RL E + E+ L+ K L L+E++K S I+E+ L
Sbjct: 387 -RGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHIS---IEEEHLRRM 442
Query: 826 RLAVLMDHDRVVEKQLLEIEHEN------KELQKKNQILLEEN-QNLQISLSDMQQHYNA 878
A L D+++ LE E E+ KE+ + +++ + L++ S HY+
Sbjct: 443 EEARLQLKDQLL---CLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDP 499
Query: 879 LVEKANRTDLAESESTKYQ---TQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQ 935
LAES+ TK Q +L++ E+ K + H+ Q + E+ E E
Sbjct: 500 ------HRWLAESK-TKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCL 552
Query: 936 IESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
+ R +++L+E + + + + + + + +E
Sbjct: 553 FQQIERQEQLLDEIHREKRDLLEETQRKDEE 583
Score = 74.1 bits (174), Expect = 4e-12
Identities = 122/552 (22%), Positives = 245/552 (44%), Gaps = 60/552 (10%)
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQV 655
S + ++ E++ E + K + L SQ +L +EL +++ ++ D+L +I Q+
Sbjct: 11 SAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI---QNHFD 67
Query: 656 CSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQ 715
E + H + QI L+ ++ E + +Q ++ E +ED+ K Q I+
Sbjct: 68 TCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIR 127
Query: 716 E----NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESEL 771
+ + L LEK S E + EL K N + K + + + A +Q+ IEN+ EL
Sbjct: 128 QWKLKHKKLERALEKQS-ETVDELTGKNNQILKEKDELKTQLYAALQQ----IENLRKEL 182
Query: 772 SKYKSRICRLEESIAVMEDRRYSLE-RKAD-------------QLGSYLQEKQKAYSEYT 817
+ ++ EE + E++ ++ +AD +L S L+++ K S+
Sbjct: 183 NDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMK 242
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK-----KNQILLEENQNLQI--SLS 870
+++ L +A L + +LLE++ K+L N++ EE + LS
Sbjct: 243 VEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 302
Query: 871 DM-QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH----QTLIVQKKKEI 925
D+ Q + E A + E +Q +L+DL S+L+ + +H Q L+ KKE
Sbjct: 303 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 362
Query: 926 EDLEIEFNTQIESAIRDKKV----------LNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
+ E T ++ +K + L + ++ E +TQ E + ++ K + L
Sbjct: 363 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 422
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNA 1035
+EE K ++ + ++H+++ + +Q + + ++L +EI A + +
Sbjct: 423 DQLEEREK-HISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKD 481
Query: 1036 QVSYMSMVS-------DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
V + + S D LA+ TKL+ + EE+ K+ + +++ +L R+Q
Sbjct: 482 SVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL----KERENREKNLRHQLMLCRQQ 537
Query: 1089 DDQIKELKETKL 1100
+ E KE++L
Sbjct: 538 LRNLTENKESEL 549
Score = 66.9 bits (156), Expect = 6e-10
Identities = 104/493 (21%), Positives = 210/493 (42%), Gaps = 37/493 (7%)
Query: 788 MEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE 847
M D R L A + S L+E ++ ++ L +++ L EKQ L++
Sbjct: 1 MSDLRVQLNFSA--MASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDR 58
Query: 848 NKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR--TDLAESESTKYQTQLRDLES 905
KE+Q E ++ + +S++ +H ++A R ++L +SE+ K + + R +
Sbjct: 59 LKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDL 118
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQ 965
LK Q + KK E LE + T E ++ ++L EK E TQL A LQ
Sbjct: 119 KLKAQESIRQWKLKHKKLE-RALEKQSETVDELTGKNNQILKEKDELK----TQLYAALQ 173
Query: 966 EYKNNIENLN--MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQ-KD 1022
+ +N + LN + L + L ++ ++ ++ D + N ++ ++ L + K
Sbjct: 174 QIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKK 233
Query: 1023 EEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
+ I K+ A + +++ + AQ KL M+E ++ +S D E +
Sbjct: 234 QSKIQSQMKVEKAHLE--EEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEE 291
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
R + +K+L + LT + E I + ++ + D + + +
Sbjct: 292 ---RAKKAVLKDLSD--LTAQAKSRDEETATIITQLK-LERDVHQRE--LKDLTSSLQSV 343
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
K + E+ +QE E E I L+ + E +++ Q+ +LKS+
Sbjct: 344 KTKHEQN-------IQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQ 396
Query: 1203 LEQLN---TENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRV 1259
++L T+N+N + + +++R I+ + ++HL + E + +L+
Sbjct: 397 CDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHIS-IEEEHLRRME----EARLQLKD 451
Query: 1260 QLSAFESKYEQLL 1272
QL E++ E +L
Sbjct: 452 QLLCLETEQESIL 464
Score = 63.7 bits (148), Expect = 5e-09
Identities = 92/480 (19%), Positives = 195/480 (40%), Gaps = 47/480 (9%)
Query: 872 MQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIE 931
+Q +++A+ + K + L NL R + +Q +++++
Sbjct: 6 VQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNH 65
Query: 932 FNT----------QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE- 980
F+T QI R + ++ E+ + + Q EA +E + E+L + +E
Sbjct: 66 FDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQES 125
Query: 981 LNKMNLELIDKHVQKQQTQSPDYTEQYINEIN-KLNALLKQKDEEIIALNQKINNAQVSY 1039
+ + L KH K+ ++ + + ++E+ K N +LK+KDE + +
Sbjct: 126 IRQWKL----KH--KKLERALEKQSETVDELTGKNNQILKEKDE--------LKTQLYAA 171
Query: 1040 MSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKEL---- 1095
+ + + +L TK EEE+ ++L D K H +L++ V+ D I L
Sbjct: 172 LQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL 231
Query: 1096 -KETKLTFEMNIPKT--EGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ 1152
K++K+ +M + K E I D A ++ ++ + +
Sbjct: 232 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLE--MQESIKDLSAIRADLANKLAE 289
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
E + L+ + ++ + T+ T+L V+Q ++ L S L+ + T+++
Sbjct: 290 EERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHE- 348
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLL 1272
+ EL + I L + L E + K R QL +S+ ++L
Sbjct: 349 --QNIQELMKHFKKEKSEAENHIRTLKAESL--EEKNMAKIH---RGQLEKLKSQCDRLT 401
Query: 1273 DSV-QSSTQEETNKI---VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+ + Q+ + + K+ +Q+ + + +EEHLR ++E + +Q+ L +E E
Sbjct: 402 EELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQE 461
Score = 52.8 bits (121), Expect = 1e-05
Identities = 64/324 (19%), Positives = 142/324 (43%), Gaps = 20/324 (6%)
Query: 1256 ELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+LRVQL+ F + +L + + +++ K QV +L +L++ E+ + ++ +
Sbjct: 3 DLRVQLN-FSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKE 61
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA 1375
+ N + +E + + L +E Q + ++E++ +
Sbjct: 62 IQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL-SELQQSEALKEEA----EKRRE 116
Query: 1376 QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE 1435
LK + ++ A K E +L K+++I ++ E L + E
Sbjct: 117 DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE 176
Query: 1436 NVRQQLVEY-EKRI--EDLTYEKESELAILRLKMH----ENANHYETMQK-ESEIERVKL 1487
N+R++L + KR E+ + KE +L ++ E N +T+ + ESE+++
Sbjct: 177 NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK 236
Query: 1488 IEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
I+ +K+ E L +++AEL K+ ++ AK EMQ +++ ++ + ++ N
Sbjct: 237 IQS-QMKV-EKAHLEEEIAELKKSQAQDKAKLLEMQESIK----DLSAIRADLANKLAEE 290
Query: 1548 RASSSKIQKHVSFASDTKQGRDEQ 1571
+ + K +S + + RDE+
Sbjct: 291 ERAKKAVLKDLSDLTAQAKSRDEE 314
Score = 52.8 bits (121), Expect = 1e-05
Identities = 95/441 (21%), Positives = 175/441 (39%), Gaps = 53/441 (12%)
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNT---ENDNLLSTVAELRSSISSAVDQRGF 1233
Q+E L EL + + +++LK +T E + ++EL A Q
Sbjct: 37 QVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAER 96
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFE-----SKYEQLLDSVQSSTQEETNKI-V 1287
++EL + + EA+ ++ + +L+ Q S + K E+ L+ + E T K
Sbjct: 97 YLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQ 156
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI--EDEKVAFXXXXXXXXXXX 1345
+++ L+ +L + + NL+++ DV+ + + E+ ++EK+
Sbjct: 157 ILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELE 216
Query: 1346 XXXXXDL--RTENQSYKQMQEQSILNIN-----EENAQLKKSSXXXXXXXXXXXXRVNDA 1398
D R E++ KQ + QS + + EE A+LKKS + D
Sbjct: 217 VKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDL 276
Query: 1399 EAKVLELTHQL---ELKDSEIYQKTHEYTITLTQRNDEFENVRQQL-VE---YEKRIEDL 1451
A +L ++L E + + + T R++E + QL +E +++ ++DL
Sbjct: 277 SAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDL 336
Query: 1452 TYEKES-----ELAILRLKMH------ENANHYETMQKES------------EIERVK-- 1486
T +S E I L H E NH T++ ES ++E++K
Sbjct: 337 TSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQ 396
Query: 1487 ---LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNL 1543
L EEL E+ L + L LEE + + L E + L D++ L
Sbjct: 397 CDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCL 456
Query: 1544 QNMVRASSSKIQKHVSFASDT 1564
+ + I K + A T
Sbjct: 457 ETEQESILGVIGKEIDAACKT 477
Score = 52.4 bits (120), Expect = 1e-05
Identities = 117/605 (19%), Positives = 237/605 (39%), Gaps = 69/605 (11%)
Query: 960 LEAQLQEYKNNIENLNMNVEELNKM--NLELIDKHVQKQQTQSPDYTEQYINEINKLNAL 1017
+ ++L+E K +E + L NL ++ +KQQ Q D ++ N + A
Sbjct: 13 MASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAE 72
Query: 1018 LKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQH 1077
K D +I L + +A +S+ + A + E+ + + + K
Sbjct: 73 RKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLK 132
Query: 1078 NEELQILVREQDDQIKEL--KETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXX 1135
+++L+ + +Q + + EL K ++ E + KT+ IE + + N+V
Sbjct: 133 HKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDV------- 185
Query: 1136 XXXXXXLKVQEEEEFIQERSV--LQEQSAKLNTELQECYTKIIQLET-------LNTELT 1186
+QEEE +E + ++ A L E++ I +LE+ + +++
Sbjct: 186 ---LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMK 242
Query: 1187 GHDVVNQEQINQLK-------SKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELW 1239
+E+I +LK +KL ++ +L + A+L + ++ + + +L
Sbjct: 243 VEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL- 301
Query: 1240 KQHLAQREADFQKTEH---ELRVQLSAFESKYEQLLDSVQS-STQEETNKIVTMEQVTSL 1295
AQ ++ ++T +L+++ + + + L S+QS T+ E N E +
Sbjct: 302 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQN---IQELMKHF 358
Query: 1296 QNKLQDKEEHLRNLQEKYADVINQIEILRSEIED---------EKVAFXXXXXXXXXXXX 1346
+ + + E H+R L+ + + N +I R ++E E++
Sbjct: 359 KKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKY 418
Query: 1347 XXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVN---DAEAKVL 1403
D E + + ++E+ + + E QLK + DA K
Sbjct: 419 QCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTF 478
Query: 1404 ELTHQLELK----DSEIYQKTHEYTIT-----------LTQRNDEFENVRQQLVEYEKRI 1448
+LK +I+ H + L +R + +N+R QL+ +++
Sbjct: 479 SKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQL 538
Query: 1449 EDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAEL 1508
+LT KESEL L + E + E E+ L+EE K E SL +V L
Sbjct: 539 RNLTENKESELQCL----FQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIAL 594
Query: 1509 NKALE 1513
+ +
Sbjct: 595 ETSTQ 599
Score = 45.2 bits (102), Expect = 0.002
Identities = 120/630 (19%), Positives = 271/630 (43%), Gaps = 80/630 (12%)
Query: 309 EIEEKGSLEIANMTE-LTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS 367
E ++K +A+ E LT+++E E Q+ KE++N T E K +
Sbjct: 25 ERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISE-- 82
Query: 368 PLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYV 427
++R + T + SE L ++ +K+ ++ E + Q K + +
Sbjct: 83 --LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 140
Query: 428 ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ 487
+ +T GK+ I L+ + ++ T+ + ++ E L++
Sbjct: 141 EKQSET-----VDELTGKNNQI----LKEKDELK----------TQLYAALQQI-ENLRK 180
Query: 488 ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF 547
ELND + +++ E+L S EE++ + +++ +L++K TI
Sbjct: 181 ELNDVLTKRALQE--EELHSKEEKLRDIKSH-----------QADLELEVKNSLDTIHRL 227
Query: 548 -SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSG----RMIESDVYKKM 602
S++ +K ++ E HL +++AEL++ + + L++ I +D+ K+
Sbjct: 228 ESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKL 287
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELH--ILQQKYDEVEDKLADISQLQSDQVCSEIK 660
E E + LK +S L +Q +E I Q K + D+ Q + + S ++
Sbjct: 288 AEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLER------DVHQRELKDLTSSLQ 341
Query: 661 SVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDL 720
SV + + + + ++++ K +K + I+ L+ E + K N + +
Sbjct: 342 SVKTKHE--------QNIQELMKHFKKEKSEAENHIRTLK--AESLEEK--NMAKIHRGQ 389
Query: 721 TDKLEKMSAEKISELLAKINHEEQSKIQTQFG-IDAKIQERDLYIENIESELSKYKSRIC 779
+KL K ++++E L + N E K++ ++ + +++ER+ +I E L + +
Sbjct: 390 LEKL-KSQCDRLTEELTQ-NENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARL 447
Query: 780 RLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR-LAVLMDHDRVVE 838
+L++ + +E + S+ +G + K +S+ ++++ ++ + + D R +
Sbjct: 448 QLKDQLLCLETEQESI---LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLA 504
Query: 839 KQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQT 898
+ +++ +EL+++ E+N Q+ L Q N T+ ESE
Sbjct: 505 ESKTKLQWLCEELKEREN--REKNLRHQLMLCRQQLR--------NLTENKESELQCLFQ 554
Query: 899 QLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
Q+ E L I E + L+ + +++ E++
Sbjct: 555 QIERQEQLLDEIHREKRDLLEETQRKDEEM 584
>AF263462-1|AAF74498.1| 1203|Homo sapiens cingulin protein.
Length = 1203
Score = 84.2 bits (199), Expect = 3e-15
Identities = 145/824 (17%), Positives = 333/824 (40%), Gaps = 59/824 (7%)
Query: 318 IANMTELTKKIELLEH-LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR 376
+A ELT+K+E L+ L+ ++++ K LE + + + + + L+ R+ G
Sbjct: 358 VAGQGELTRKVEELQRKLDEEVKKRQK-LEPSQVGLERQLEEKTEECSRLQELLERRKGE 416
Query: 377 NTASKMKSPWSQLSSETLNQDTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
S + Q L+Q D + + ++ +L+ ++ + KE ++ +
Sbjct: 417 AQQSNKEL---QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETR 473
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
GK + QL+L ++ + + D E+ V++Q +++
Sbjct: 474 ELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDT------ 526
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
E+L+ + + TQ + ++A + M + + +L++ + ++ + NK
Sbjct: 527 -------EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
Query: 556 EIVRLT-EELHHLSQKVAELEEEKGNL------QLHLVDYDSGRMIESDVYKKMI----- 603
E +R T +EL L + E+EEE G +L +G + +V KK +
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYD---EVEDKLADISQL--QSDQVCSE 658
E++ L R + +L ++L +L+ + D E+E++ + + Q Q C E
Sbjct: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
Query: 659 IKSVHLEEQIDALSASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE 716
+ + +A ++ A+ + + + ++ I LE ++ +
Sbjct: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
Query: 717 NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
L DKL+++ AEK + E L EE S + ++A+++E + + E
Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
Query: 775 KSRICR-------LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ L A +E+++ L+R D+L L EK S+ +Q+ +
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL-EKIGEDSKQALQQLQ----- 873
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A L D+ +++ + + + K+ + + LQ + ++Q A +A R D
Sbjct: 874 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQA--SQAER-D 930
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
A + +L+ LE + Q ++ K +E+ T+++ ++L
Sbjct: 931 TARLDKELLAQRLQGLEQEAEN-KKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLT 989
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
++ + + V QL +L + ++ ++L + L + N +L + + Q P +
Sbjct: 990 DRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQ 1049
Query: 1008 INEINK-LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ N+ L L+ ++ E L + + E + + + + ++
Sbjct: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKA 1109
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
+ +Q+ ++++ E L L ++ +++E E + I E
Sbjct: 1110 LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153
Score = 69.3 bits (162), Expect = 1e-10
Identities = 118/677 (17%), Positives = 292/677 (43%), Gaps = 49/677 (7%)
Query: 221 MQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQ 280
++E + + E + +Q+ +D E + + + +LEA R ++S L +ELE+
Sbjct: 504 LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
Query: 281 XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE-EKGSLEIANMTELTKKIELLEHLNCQIR 339
K+ + + +E ++ EK +E EL +KIE+L+ Q R
Sbjct: 564 TSEETGHWQSMFQK-NKEDLRATKQELLQLRMEKEEME----EELGEKIEVLQRELEQAR 618
Query: 340 QT---NKELE-NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLN 395
+ +++E K + T+ + +++ S + +GR+ +++ QL+ +
Sbjct: 619 ASAGDTRQVEVLKKELLRTQEELKELQAERQSQEV---AGRHRDRELE---KQLAVLRVE 672
Query: 396 QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
D +++ + + +L+ +Q L +D + + +T + + Q E
Sbjct: 673 ADRGRELEEQNL-QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE 731
Query: 456 HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIK--DVNVKDLIEKLKSAEEQIT 513
+ + ++ + ++ + E ++ L D+++ + + L E L +++E+
Sbjct: 732 NDEFRR--RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEG 789
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAE 573
L A + + + +L Q Q+T++ + +E++R + +++ +
Sbjct: 790 SLAAAKRALEARLEEAQRG-LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 848
Query: 574 LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHIL 633
++ N +L + DS + ++ + ++E+ E + ++ + Q D E
Sbjct: 849 RTVDRLNKELEKIGEDSKQALQ----QLQAQLEDYKEKARREVADAQRQAKDWASEAEKT 904
Query: 634 QQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
++D++ + Q LQ+ Q +E + L++++ L+ + L EN K ++
Sbjct: 905 SGGLSRLQDEIQRLRQALQASQ--AERDTARLDKEL--LAQRLQGLEQEAENKKRSQDDR 960
Query: 693 YGTIKDLE----------NDKEDIMNKLQNYIQENMDLTDKL--EKMSAEKISELLA--K 738
+K LE +++++ + L + + D D+L E M + L K
Sbjct: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
Query: 739 INHEEQSK-IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
I+ E Q+K ++T+ Q+ + +ES+ + R+ E V++ LER
Sbjct: 1021 ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1080
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
K +L ++++++ ++ Q+D+L R+ L E+++ ++ K+ Q++ +
Sbjct: 1081 KVKELSIQIEDERQHVND---QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
Query: 858 LLEENQNLQISLSDMQQ 874
E N+ LQ + +++
Sbjct: 1138 QHEVNEQLQARIKSLEK 1154
Score = 64.9 bits (151), Expect = 2e-09
Identities = 144/814 (17%), Positives = 326/814 (40%), Gaps = 47/814 (5%)
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
L+RK D+ ++++QK E +L + ++E++ E + NKELQ
Sbjct: 371 LQRKLDE---EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ LL++ ++L+ L ++ + A+ K + R+L +
Sbjct: 428 KR-LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-------TQ----LEAQ 963
+ + +++E+ L+ ++ S ++ + + ++Y+++ E + TQ LEA+
Sbjct: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE 546
Query: 964 LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
Q+ + L +EE ++ QK + ++ + + + ++ E
Sbjct: 547 RQKMSALVRGLQRELEETSEETGHW-QSMFQKNKEDLRATKQELLQLRMEKEEMEEELGE 605
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE-ELQ 1082
+I L +++ A+ S K T+ E E + +R S+++ + E E Q
Sbjct: 606 KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQ 665
Query: 1083 ILV-REQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V R + D+ +EL+E L + + + ++ M +A
Sbjct: 666 LAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL 725
Query: 1142 LKVQEEEEFIQERSVLQEQSAKLNTELQE--------CYTKIIQLETLNTELTGHDVVNQ 1193
+ QEE + + R + EQ K L + K+ +LE +L +Q
Sbjct: 726 RETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQ 785
Query: 1194 EQINQL---KSKLEQLNTENDNLLSTVAELRSSISSAVDQRG--FEIAELWKQHLAQREA 1248
E+ L K LE E L+ + + + +++ A+++ G E+ K L +++
Sbjct: 786 EEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKR 845
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
+T L +L +Q L +Q+ ++ K +V Q + +D
Sbjct: 846 LLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEK--ARREVADAQRQAKDWASEAEK 903
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQE---Q 1365
+ + ++I+ LR ++ + A L E ++ K+ Q+ +
Sbjct: 904 TSGGLSRLQDEIQRLRQALQASQ-AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRAR 962
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+ + E+ ++L+ RVN +V +L +L +++ Q I
Sbjct: 963 QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL-MQERSARQDLECDKI 1021
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLT-YEKESELAILRLKMHENANHYETMQKESEIER 1484
+L ++N + + ++K L+ E +++L RL+ E +T+ + + +
Sbjct: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE---KTVLQSTNRKL 1078
Query: 1485 VKLIEELNVKI-TESVSLNKQVAELN---KALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
+ ++EL+++I E +N Q +L+ KAL+ +V + E L+ + +E
Sbjct: 1079 ERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQ 1138
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
+ ++A ++K S+ ++ + L N
Sbjct: 1139 HEVNEQLQARIKSLEKD-SWRKASRSAAESALKN 1171
Score = 42.3 bits (95), Expect = 0.014
Identities = 122/690 (17%), Positives = 280/690 (40%), Gaps = 50/690 (7%)
Query: 55 ERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKEL 114
E ++ LE V ++++ + L G + E +A+ ++ E + ++ ++ E
Sbjct: 474 ELLEEVLEGKQRVEEQLRLRERELTALKG-----ALKEEVASRDQEVEHVRQQYQRDTEQ 528
Query: 115 SKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILD 174
+RS + G L T +E + S+ Q + + T +
Sbjct: 529 LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQE 588
Query: 175 LQEKINEKDQIIEAKNKA--TTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEW 232
L + EK+++ E + E K+++ + QE ++AE
Sbjct: 589 LLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAER 648
Query: 233 KDEKQR-LLKDIE-SKDVRISSLE-EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
+ ++ +D E K + + +E + + LE ++ +L Q+ E+
Sbjct: 649 QSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAE 708
Query: 290 XXXXXLAKQ--SIEPSCEEKTEIEEKGSLEIANMTELTKKIELL----EHLNCQIRQTNK 343
L ++ ++E + E E ++ I + + K+ L E + ++R +
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 768
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSE--TLNQDTDKK 401
LE + + E +S ++GS ++++ + + ++L E TLN+ +++
Sbjct: 769 RLEAEKQQL--EEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 826
Query: 402 INKNEI-----AKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTLI-AQLQ 453
+ E+ A+LE + L++ D ++KE +D+ +D A+ +
Sbjct: 827 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 886
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV----KDLI-EKLKSA 508
+ Q + ++ + ++L+Q L + + K+L+ ++L+
Sbjct: 887 VADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL 946
Query: 509 EEQI-TQLNDEIDAAN--KNMIKVKSNHKLKLKQMQKTIDNFS-KVSDSNKEIVRLTEEL 564
E++ + + D A K + + S + +L + + T++ + +V+ ++ +L EL
Sbjct: 947 EQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL 1006
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLE 620
+LE +K +L+ D + R+ S+ ++K + ++E+ + + + E
Sbjct: 1007 MQERSARQDLECDKISLERQNKDLKT-RLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1065
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQL---QSDQVCSEIKSV-----HLEEQIDALS 672
+K L L++K E+ ++ D Q Q DQ+ +K++ EE+I+ L
Sbjct: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLEND 702
+K+ +E EQL IK LE D
Sbjct: 1126 GLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155
>AF032862-1|AAC32548.1| 724|Homo sapiens intracellular hyaluronic
acid binding protein protein.
Length = 724
Score = 84.2 bits (199), Expect = 3e-15
Identities = 132/654 (20%), Positives = 300/654 (45%), Gaps = 49/654 (7%)
Query: 480 KVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDE----IDAANKNMIKVKSNHKL 535
K Q++ KQ LN + KD + K+KS+E + +Q ND+ ++ + +++ +
Sbjct: 45 KQQKESKQNLNVD-KDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDS 103
Query: 536 KLKQMQKTIDNF-SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
+++ ++ ++ ++++ + +E L+ L +++ EL L+ + + + +
Sbjct: 104 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL 163
Query: 595 ESDVYKKMIEMENLAETRLKAISLLE---SQKFDLVQ-ELHILQQKYDEVEDKLADISQL 650
+ +++++ N ET+++ + + K + Q L Q K ++E KL I +
Sbjct: 164 RI-LSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 222
Query: 651 QSDQVCSEIKSVHLEEQI----DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDI 706
+ D+ K + E+I D + K ++A + ENLK +++ + LE + I
Sbjct: 223 KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE-ENIVI 281
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGID----AKIQERDL 762
++K + L +K ++ + E +N E Q+ ++ +F ++ K+Q+++L
Sbjct: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQN-LKQKFILEQQEREKLQQKEL 340
Query: 763 YIENI---ESEL-SKYKSRICRLEESIAVMEDRRY--SLERKADQLGSYLQEKQKAYSEY 816
I+++ E EL S ++C +E + V E + L++ D+L Q++++A
Sbjct: 341 QIDSLLQQEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQTLDELDKLQQKEEQAERLV 399
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQ--- 873
E+E +R L + ++ + E+E + + +L E+ ++ SL D+
Sbjct: 400 KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF 459
Query: 874 QHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFN 933
+ Y AL A+ + + E++ Q + N + + +HQ L + + E + + +
Sbjct: 460 ESYKALT--ASEIEDLKLENSSLQEKAAKAGKNAEDV--QHQILATESSNQ-EYVRMLLD 514
Query: 934 TQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHV 993
Q +SA+++ ++ E ++ +T L+ QL++ + + + EE K E +
Sbjct: 515 LQTKSALKETEI-KEITVSFLQKITDLQNQLKQQEEDFRK-QLEDEEGRKAEKENTTAEL 572
Query: 994 QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQF 1053
++ + E+ N+ L + E AL + AQ ++ + D +KL
Sbjct: 573 TEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ-EQLNKIRDSYAKLLGH 631
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQI--KELKETKLTFEMN 1105
+N++++++ V K K N +L+ V + Q+ K+ ETKL E+N
Sbjct: 632 ----QNLKQKIKHVVK----LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 677
Score = 83.0 bits (196), Expect = 8e-15
Identities = 148/688 (21%), Positives = 295/688 (42%), Gaps = 72/688 (10%)
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKY-EKNIEYVTQLEAQ----LQEYKNNIENL 974
Q+K+ ++L ++ +T + ++ R K K +KN + + LE + LQE +
Sbjct: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDSRI 105
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQKDEEIIALNQK-I 1032
EL KM L +K + + T E+ + E+ + N LLK K E NQK +
Sbjct: 106 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE--NGNQKNL 163
Query: 1033 NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ-ILVREQDDQ 1091
+ M + + E+K+ K E ME ++Q + L +S+ +L+ LV + ++
Sbjct: 164 RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 223
Query: 1092 IKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI 1151
I E ET+ E IE +S ++ V+ LK ++ +E +
Sbjct: 224 IDEKSETEKLLEY-------------IEEISCASDQVEKYKLDIAQLEENLK-EKNDEIL 269
Query: 1152 QERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND 1211
+ L+E L+ Q+E LN + + ++ +N+ + E LN E
Sbjct: 270 SLKQSLEENIVILSK----------QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQ 319
Query: 1212 NLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT---EHELRVQLSAFESKY 1268
NL L + Q+ +I L +Q + QK + E+ + + FE +
Sbjct: 320 NLKQKFI-LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEEL 378
Query: 1269 EQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIE 1328
+Q LD + Q+E ++Q L+ + + + E L+ L+EK + E+ +S
Sbjct: 379 KQTLDELDKLQQKEEQAERLVKQ---LEEEAKSRAEELKLLEEKLKG--KEAELEKSSAA 433
Query: 1329 DEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXX 1388
+ D+ + +SYK + I ++ EN+ L++ +
Sbjct: 434 HTQATLLLQEKYDSMVQSLE--DVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNA 491
Query: 1389 XXXXXRVNDAEAK-------VLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN-VRQQ 1440
++ E+ +L+L + LK++EI E T++ Q+ + +N ++QQ
Sbjct: 492 EDVQHQILATESSNQEYVRMLLDLQTKSALKETEI----KEITVSFLQKITDLQNQLKQQ 547
Query: 1441 LVEYEKRIED---LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITE 1497
++ K++ED EKE+ A L ++++ YE + +++ +++L ++ +
Sbjct: 548 EEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA---FEVEK 604
Query: 1498 SVSLNKQVA---ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKI 1554
LN+ A +LNK + + AK Q L+ + +V L DE + L++ V SK+
Sbjct: 605 QALLNEHGAAQEQLNK-IRDSYAKLLGHQN-LKQKIKHVVKLKDENSQLKSEV----SKL 658
Query: 1555 QKHVSFASDTKQGRDEQLDNTMNKELLD 1582
+ ++ ++ E+L+ + + D
Sbjct: 659 RCQLAKKKQSETKLQEELNKVLGIKHFD 686
Score = 77.0 bits (181), Expect = 5e-13
Identities = 122/613 (19%), Positives = 267/613 (43%), Gaps = 50/613 (8%)
Query: 485 LKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM-QKT 543
L++E+ +++ +D +++ E ++ ++ ++AA + + +N+ KQ+ + T
Sbjct: 87 LEKEIRVLLQERGAQD--SRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 144
Query: 544 IDNF---SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYK 600
N SK S++ + + L LS ++ +L ++ ++ G ++ V +
Sbjct: 145 RTNELLKSKFSENGNQ-----KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 199
Query: 601 KMIEMEN--LAETRLKAISLLESQKFD-------LVQELHILQQKYDEVEDKLADISQLQ 651
+ +E +A+ K +S+ E +K D L++ + + D+VE DI+QL+
Sbjct: 200 RSLEESQGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 258
Query: 652 SD--QVCSEIKSVH--LEEQIDALSASKKELALVIENLKLDKEQLYGTIKDL-ENDKEDI 706
+ + EI S+ LEE I LS ++L + + L+ +KE ++ EN ++
Sbjct: 259 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEM 318
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAK-IQERDLYIE 765
N Q +I E + +KL++ + I LL + S Q + ++E++L+ E
Sbjct: 319 QNLKQKFILEQQE-REKLQQKELQ-IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEE 376
Query: 766 NIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVN 825
++ L + + E++ +++ + +A++L L+EK K E +++ +
Sbjct: 377 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL-KLLEEKLKG-KEAELEKSSAAH 434
Query: 826 RLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR 885
A L+ ++ + + +E + + + E ++L++ S +Q+ + A
Sbjct: 435 TQATLLLQEKY-DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED 493
Query: 886 TD----LAESESTKYQTQLRDL-------ESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
ES + +Y L DL E+ +K IT I + +++ E +F
Sbjct: 494 VQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRK 553
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q+E K + E + + +E N + + ++ L+++H
Sbjct: 554 QLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGA 613
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFT 1054
Q+ Q + Y + N LKQK + ++ L K N+Q+ S VS +LA+
Sbjct: 614 AQE-QLNKIRDSYAKLLGHQN--LKQKIKHVVKL--KDENSQLK--SEVSKLRCQLAKKK 666
Query: 1055 TKLENMEEEMQRV 1067
++EE+ +V
Sbjct: 667 QSETKLQEELNKV 679
Score = 73.7 bits (173), Expect = 5e-12
Identities = 108/501 (21%), Positives = 218/501 (43%), Gaps = 47/501 (9%)
Query: 839 KQLLEIEHENKELQKKNQILLEEN-------QNLQISLSDMQQHYNALVEKANRTDLAES 891
K+ + + + K L+K+ ++LL+E Q+L+ L M+ NA + + +T L+ +
Sbjct: 75 KESQKNDKDLKILEKEIRVLLQERGAQDSRIQDLETELEKMEARLNAALRE--KTSLSAN 132
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI-EFNTQIESAIRDKKVLNEKY 950
+T + QL +L + + + QK I LE+ + + E+ +R E
Sbjct: 133 NAT-LEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGM 191
Query: 951 EKNIEYVTQLEAQLQEYK-NNIENLNMNVEELN---KMNLELIDKHVQKQQTQSPDYTEQ 1006
E ++ VTQ + + K +E +++E+ K E + +++++ S D E+
Sbjct: 192 EMKLQ-VTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS-DQVEK 249
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLE-------- 1058
Y +I +L LK+K++EI++L Q + V V D K + E
Sbjct: 250 YKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNRE 309
Query: 1059 ---NMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIIS 1115
N+ EMQ + ++ + +Q E+LQ + D +++ KE + +
Sbjct: 310 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK--------LC 361
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ-EQSAKLNTELQECYTK 1174
S E M + N + L+ +EE+ ER V Q E+ AK E + +
Sbjct: 362 SFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ---AERLVKQLEEEAKSRAEELKLLEE 418
Query: 1175 IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
+L+ EL + + L+ K + + +++ + ++ +S ++ E
Sbjct: 419 --KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 476
Query: 1235 IAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN-KIVT---ME 1290
+ L ++ A+ + + +H++ S+ + LLD S +ET K +T ++
Sbjct: 477 NSSL-QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 535
Query: 1291 QVTSLQNKLQDKEEHLRNLQE 1311
++T LQN+L+ +EE R E
Sbjct: 536 KITDLQNQLKQQEEDFRKQLE 556
Score = 51.6 bits (118), Expect = 2e-05
Identities = 134/692 (19%), Positives = 281/692 (40%), Gaps = 66/692 (9%)
Query: 235 EKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXX 294
E Q+ KD++ + I L + ++ ++ E K+ L
Sbjct: 76 ESQKNDKDLKILEKEIRVLLQERGAQDSRIQDLETELEKMEARLNAALREKTSLSANNAT 135
Query: 295 LAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
L KQ IE + E+ + E N L +I LE + + ++ K G
Sbjct: 136 LEKQLIELT--RTNELLKSKFSENGNQKNL--RILSLELMKLRNKRETKMRGMMAKQEGM 191
Query: 355 ESKA-VSSPSKKGSP-LISRKSGRNTASKMKSPWSQLSSETLNQDTDK-KINKNEIAKLE 411
E K V+ S + S I++ G+ + + + + +E L + ++ +++ K +
Sbjct: 192 EMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYK 251
Query: 412 MVIQSLNKDLVDK-EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGT 470
+ I L ++L +K + ++S K + + L + QL ++ + HV
Sbjct: 252 LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED-----HVNR 306
Query: 471 NTEDVNEIAKVQEQLKQEL---NDEIKDVNVKDL-IEKLKSAEEQITQ-LNDEIDAANKN 525
N E + + LKQ+ E + + K+L I+ L E++++ L+ ++ + +
Sbjct: 307 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE 366
Query: 526 MIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHL 585
M+K K+ + +LKQ D K+ ++ RL V +LEEE + L
Sbjct: 367 MVKEKNLFEEELKQTL---DELDKLQQKEEQAERL----------VKQLEEEAKSRAEEL 413
Query: 586 VDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD------- 638
+++E + K E+E + +A LL+ + +VQ L + +++
Sbjct: 414 ------KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 467
Query: 639 -EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIK 697
E+ED + S LQ + + ++ QI A +S +E ++ +L Q +K
Sbjct: 468 SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL-----QTKSALK 522
Query: 698 DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKI 757
+ E I +++Q+ DL ++L K E + L + K T + +I
Sbjct: 523 ETE-----IKEITVSFLQKITDLQNQL-KQQEEDFRKQLEDEEGRKAEKENTTAELTEEI 576
Query: 758 QERDLYIENIESELSKYKSRICRLE-ESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEY 816
+ L E + ++ ++ ++ E E A++ + + E QL K
Sbjct: 577 NKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE----QLNKIRDSYAKLLGHQ 632
Query: 817 TIQEDELVNRLAVLMDHDRVVEKQLLEIEHE-NKELQKKNQILLEENQNLQISLSDMQQ- 874
+++ + + L D + ++ ++ ++ + K+ Q + ++ E N+ L I D +
Sbjct: 633 NLKQK--IKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 690
Query: 875 -HYNALVEKANRTDLAESESTKYQTQLRDLES 905
H+ + A +T L E + Y+ + ES
Sbjct: 691 FHHESKENFALKTPLKEGNTNCYRAPMECQES 722
Score = 43.2 bits (97), Expect = 0.008
Identities = 76/460 (16%), Positives = 184/460 (40%), Gaps = 20/460 (4%)
Query: 1142 LKVQEEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
LK+ E+E +QER + L TEL++ ++ T L+ ++ ++Q+ +L
Sbjct: 84 LKILEKEIRVLLQERGAQDSRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 143
Query: 1200 KSKLEQLNT---ENDNLLSTVAELRSSISSAVDQRGFEIAELW-KQHLAQREADF-QKTE 1254
E L + EN N + L + ++R ++ + KQ + + Q++
Sbjct: 144 TRTNELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 202
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT-MEQVTSLQNKLQDKEEHLRNLQEKY 1313
E + +++ E K + + + + ET K++ +E+++ ++++ + + L+E
Sbjct: 203 EESQGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 261
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ ++I L+ +E+ V L E + + + N+N E
Sbjct: 262 KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL----LEKEKEDHVNRNREHNENLNAE 317
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
LK+ ++ E ++ L Q + S ++QK + + + +
Sbjct: 318 MQNLKQK----FILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNL 373
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
FE +Q ++ +++ + E + L + A + ++++ + + +L +
Sbjct: 374 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 433
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTL-NDEITNLQNMVRASSS 1552
++ L ++ + ++LE+ A+ E AL EIE + L N + ++
Sbjct: 434 HTQATLLLQEKYDSMVQSLEDVTAQF-ESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 492
Query: 1553 KIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+Q + + Q L + K L E+ ++
Sbjct: 493 DVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVS 532
>AB037740-1|BAA92557.1| 1208|Homo sapiens KIAA1319 protein protein.
Length = 1208
Score = 84.2 bits (199), Expect = 3e-15
Identities = 145/824 (17%), Positives = 333/824 (40%), Gaps = 59/824 (7%)
Query: 318 IANMTELTKKIELLEH-LNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR 376
+A ELT+K+E L+ L+ ++++ K LE + + + + + L+ R+ G
Sbjct: 363 VAGQGELTRKVEELQRKLDEEVKKRQK-LEPSQVGLERQLEEKTEECSRLQELLERRKGE 421
Query: 377 NTASKMKSPWSQLSSETLNQDTDKKIN-KNEIAKLEMVIQSLNKDLVDKEYVISEKDTXX 435
S + Q L+Q D + + ++ +L+ ++ + KE ++ +
Sbjct: 422 AQQSNKEL---QNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETR 478
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKD 495
GK + QL+L ++ + + D E+ V++Q +++
Sbjct: 479 ELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDT------ 531
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
E+L+ + + TQ + ++A + M + + +L++ + ++ + NK
Sbjct: 532 -------EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 584
Query: 556 EIVRLT-EELHHLSQKVAELEEEKGNL------QLHLVDYDSGRMIESDVYKKMI----- 603
E +R T +EL L + E+EEE G +L +G + +V KK +
Sbjct: 585 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 644
Query: 604 EMENLAETRLKAISLLESQKFDLVQELHILQQKYD---EVEDKLADISQL--QSDQVCSE 658
E++ L R + +L ++L +L+ + D E+E++ + + Q Q C E
Sbjct: 645 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 704
Query: 659 IKSVHLEEQIDALSASKKELAL--VIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQE 716
+ + +A ++ A+ + + + ++ I LE ++ +
Sbjct: 705 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 764
Query: 717 NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKY 774
L DKL+++ AEK + E L EE S + ++A+++E + + E
Sbjct: 765 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 824
Query: 775 KSRICR-------LEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL 827
+ L A +E+++ L+R D+L L EK S+ +Q+ +
Sbjct: 825 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL-EKIGEDSKQALQQLQ----- 878
Query: 828 AVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD 887
A L D+ +++ + + + K+ + + LQ + ++Q A +A R D
Sbjct: 879 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQA--SQAER-D 935
Query: 888 LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLN 947
A + +L+ LE + Q ++ K +E+ T+++ ++L
Sbjct: 936 TARLDKELLAQRLQGLEQEAEN-KKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLT 994
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
++ + + V QL +L + ++ ++L + L + N +L + + Q P +
Sbjct: 995 DRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQ 1054
Query: 1008 INEINK-LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ N+ L L+ ++ E L + + E + + + + ++
Sbjct: 1055 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKA 1114
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTE 1110
+ +Q+ ++++ E L L ++ +++E E + I E
Sbjct: 1115 LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1158
Score = 69.3 bits (162), Expect = 1e-10
Identities = 118/677 (17%), Positives = 292/677 (43%), Gaps = 49/677 (7%)
Query: 221 MQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQ 280
++E + + E + +Q+ +D E + + + +LEA R ++S L +ELE+
Sbjct: 509 LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 568
Query: 281 XXXXXXXXXXXXXXLAKQSIEPSCEEKTEIE-EKGSLEIANMTELTKKIELLEHLNCQIR 339
K+ + + +E ++ EK +E EL +KIE+L+ Q R
Sbjct: 569 TSEETGHWQSMFQK-NKEDLRATKQELLQLRMEKEEME----EELGEKIEVLQRELEQAR 623
Query: 340 QT---NKELE-NKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLN 395
+ +++E K + T+ + +++ S + +GR+ +++ QL+ +
Sbjct: 624 ASAGDTRQVEVLKKELLRTQEELKELQAERQSQEV---AGRHRDRELE---KQLAVLRVE 677
Query: 396 QDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLE 455
D +++ + + +L+ +Q L +D + + +T + + Q E
Sbjct: 678 ADRGRELEEQNL-QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE 736
Query: 456 HQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIK--DVNVKDLIEKLKSAEEQIT 513
+ + ++ + ++ + E ++ L D+++ + + L E L +++E+
Sbjct: 737 NDEFRR--RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEG 794
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAE 573
L A + + + +L Q Q+T++ + +E++R + +++ +
Sbjct: 795 SLAAAKRALEARLEEAQRG-LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 853
Query: 574 LEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHIL 633
++ N +L + DS + ++ + ++E+ E + ++ + Q D E
Sbjct: 854 RTVDRLNKELEKIGEDSKQALQ----QLQAQLEDYKEKARREVADAQRQAKDWASEAEKT 909
Query: 634 QQKYDEVEDKLADISQ-LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
++D++ + Q LQ+ Q +E + L++++ L+ + L EN K ++
Sbjct: 910 SGGLSRLQDEIQRLRQALQASQ--AERDTARLDKEL--LAQRLQGLEQEAENKKRSQDDR 965
Query: 693 YGTIKDLE----------NDKEDIMNKLQNYIQENMDLTDKL--EKMSAEKISELLA--K 738
+K LE +++++ + L + + D D+L E M + L K
Sbjct: 966 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1025
Query: 739 INHEEQSK-IQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
I+ E Q+K ++T+ Q+ + +ES+ + R+ E V++ LER
Sbjct: 1026 ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1085
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
K +L ++++++ ++ Q+D+L R+ L E+++ ++ K+ Q++ +
Sbjct: 1086 KVKELSIQIEDERQHVND---QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1142
Query: 858 LLEENQNLQISLSDMQQ 874
E N+ LQ + +++
Sbjct: 1143 QHEVNEQLQARIKSLEK 1159
Score = 64.9 bits (151), Expect = 2e-09
Identities = 144/814 (17%), Positives = 326/814 (40%), Gaps = 47/814 (5%)
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
L+RK D+ ++++QK E +L + ++E++ E + NKELQ
Sbjct: 376 LQRKLDE---EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 432
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ LL++ ++L+ L ++ + A+ K + R+L +
Sbjct: 433 KR-LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 491
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYV-------TQ----LEAQ 963
+ + +++E+ L+ ++ S ++ + + ++Y+++ E + TQ LEA+
Sbjct: 492 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE 551
Query: 964 LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDE 1023
Q+ + L +EE ++ QK + ++ + + + ++ E
Sbjct: 552 RQKMSALVRGLQRELEETSEETGHW-QSMFQKNKEDLRATKQELLQLRMEKEEMEEELGE 610
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNE-ELQ 1082
+I L +++ A+ S K T+ E E + +R S+++ + E E Q
Sbjct: 611 KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQ 670
Query: 1083 ILV-REQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
+ V R + D+ +EL+E L + + + ++ M +A
Sbjct: 671 LAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL 730
Query: 1142 LKVQEEEEFIQERSVLQEQSAKLNTELQE--------CYTKIIQLETLNTELTGHDVVNQ 1193
+ QEE + + R + EQ K L + K+ +LE +L +Q
Sbjct: 731 RETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQ 790
Query: 1194 EQINQL---KSKLEQLNTENDNLLSTVAELRSSISSAVDQRG--FEIAELWKQHLAQREA 1248
E+ L K LE E L+ + + + +++ A+++ G E+ K L +++
Sbjct: 791 EEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKR 850
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
+T L +L +Q L +Q+ ++ K +V Q + +D
Sbjct: 851 LLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEK--ARREVADAQRQAKDWASEAEK 908
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQE---Q 1365
+ + ++I+ LR ++ + A L E ++ K+ Q+ +
Sbjct: 909 TSGGLSRLQDEIQRLRQALQASQ-AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRAR 967
Query: 1366 SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTI 1425
+ + E+ ++L+ RVN +V +L +L +++ Q I
Sbjct: 968 QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL-MQERSARQDLECDKI 1026
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLT-YEKESELAILRLKMHENANHYETMQKESEIER 1484
+L ++N + + ++K L+ E +++L RL+ E +T+ + + +
Sbjct: 1027 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE---KTVLQSTNRKL 1083
Query: 1485 VKLIEELNVKI-TESVSLNKQVAELN---KALEEEVAKTNEMQTALENQEIEIVTLNDEI 1540
+ ++EL+++I E +N Q +L+ KAL+ +V + E L+ + +E
Sbjct: 1084 ERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQ 1143
Query: 1541 TNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDN 1574
+ ++A ++K S+ ++ + L N
Sbjct: 1144 HEVNEQLQARIKSLEKD-SWRKASRSAAESALKN 1176
Score = 42.3 bits (95), Expect = 0.014
Identities = 122/690 (17%), Positives = 280/690 (40%), Gaps = 50/690 (7%)
Query: 55 ERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKEL 114
E ++ LE V ++++ + L G + E +A+ ++ E + ++ ++ E
Sbjct: 479 ELLEEVLEGKQRVEEQLRLRERELTALKG-----ALKEEVASRDQEVEHVRQQYQRDTEQ 533
Query: 115 SKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMETTILD 174
+RS + G L T +E + S+ Q + + T +
Sbjct: 534 LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQE 593
Query: 175 LQEKINEKDQIIEAKNKA--TTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEW 232
L + EK+++ E + E K+++ + QE ++AE
Sbjct: 594 LLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAER 653
Query: 233 KDEKQR-LLKDIE-SKDVRISSLE-EANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
+ ++ +D E K + + +E + + LE ++ +L Q+ E+
Sbjct: 654 QSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAE 713
Query: 290 XXXXXLAKQ--SIEPSCEEKTEIEEKGSLEIANMTELTKKIELL----EHLNCQIRQTNK 343
L ++ ++E + E E ++ I + + K+ L E + ++R +
Sbjct: 714 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 773
Query: 344 ELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSE--TLNQDTDKK 401
LE + + E +S ++GS ++++ + + ++L E TLN+ +++
Sbjct: 774 RLEAEKQQL--EEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 831
Query: 402 INKNEI-----AKLEMVIQSLNK--DLVDKEYVISEKDTXXXXXXXXXXGKDTLI-AQLQ 453
+ E+ A+LE + L++ D ++KE +D+ +D A+ +
Sbjct: 832 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 891
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNV----KDLI-EKLKSA 508
+ Q + ++ + ++L+Q L + + K+L+ ++L+
Sbjct: 892 VADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL 951
Query: 509 EEQI-TQLNDEIDAAN--KNMIKVKSNHKLKLKQMQKTIDNFS-KVSDSNKEIVRLTEEL 564
E++ + + D A K + + S + +L + + T++ + +V+ ++ +L EL
Sbjct: 952 EQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL 1011
Query: 565 HHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK----MIEMENLAETRLKAISLLE 620
+LE +K +L+ D + R+ S+ ++K + ++E+ + + + E
Sbjct: 1012 MQERSARQDLECDKISLERQNKDLKT-RLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1070
Query: 621 SQKFDLVQELHILQQKYDEVEDKLADISQL---QSDQVCSEIKSV-----HLEEQIDALS 672
+K L L++K E+ ++ D Q Q DQ+ +K++ EE+I+ L
Sbjct: 1071 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1130
Query: 673 ASKKELALVIENLKLDKEQLYGTIKDLEND 702
+K+ +E EQL IK LE D
Sbjct: 1131 GLRKKAQREVEEQHEVNEQLQARIKSLEKD 1160
>Z11584-1|CAA77670.1| 2101|Homo sapiens NuMA protein protein.
Length = 2101
Score = 83.8 bits (198), Expect = 5e-15
Identities = 178/901 (19%), Positives = 351/901 (38%), Gaps = 85/901 (9%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEK---ISELLAKINHEEQSKIQTQFGIDAKIQERDLY 763
M +L+ + + D+LE AE ++E A+I +Q +I ++ K L
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQ-RIDRLALLNEKQAASPLE 274
Query: 764 IENIESELSKYKSRICRLEESIAVMED---RRYSLERKADQLGSY---LQEKQKAYSEYT 817
+ +E K +S RL E++ +D + ++RK +QL L K + ++ +
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQ---KKNQILLEENQNLQISLSDMQQ 874
Q + +N L +H + ++ L + KEL + + L E+N+ LQ LS +++
Sbjct: 335 QQLQDALNELTE--EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 875 HYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT 934
H + L + + + E QL L+ + + Q + +E LE E
Sbjct: 393 HLSQLQDNPPQE---KGEVLGDVLQLETLKQEAATLAANN----TQLQARVEMLETERGQ 445
Query: 935 QIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQ 994
Q + ++ E+ + QL + + + +++I NL+ EEL + + H
Sbjct: 446 QEAKLLAERGHFEEEKQ-------QLSSLITDLQSSISNLSQAKEELEQAS----QAHGA 494
Query: 995 KQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYES------ 1048
+ Q T +E+ LNA ++Q+D+E+ L Q+ Q + E
Sbjct: 495 RLTAQVASLT----SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR 550
Query: 1049 -KLAQFTTKLENMEEEMQRVS-KQLLDSKQHNEELQILVREQDDQIKE----LKETKLTF 1102
++ Q ++ L+ E++++ V+ KQ + H ++L E++ ++E LK+ +
Sbjct: 551 HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALE 610
Query: 1103 EMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFI----QERSVLQ 1158
+ K E + + + D+ KV+E + + QE+ Q
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
Query: 1159 EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVA 1218
Q A+L +L+ K + E + E D + QEQ+ LK L+ + A
Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQE---KDQL-QEQLQALKESLKVTKGSLEEEKRRAA 726
Query: 1219 ELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSS 1278
+ + + E L +QH +R K E R E++ QL ++ Q+
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRER-----KELEEERAGRKGLEARLLQLGEAHQAE 781
Query: 1279 TQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXX 1338
T+ V ++ E L ++ A + E + E F
Sbjct: 782 TE------VLRRELAEAMAAQHTAESECEQLVKEVAAWRDGYEDSQQEEAQYGAMFQEQL 835
Query: 1339 XXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+L+ + ++ S L I+ + +L + +V +
Sbjct: 836 MTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNKLAE----LHANLARALQQVQEK 891
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYT--ITLTQR-NDEFENVRQQLVEYEKRIEDLTYEK 1455
E + +L L ++ + E TL ++ ++ E ++LV+ R D E
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
Query: 1456 ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEE 1515
E + + A + M++E+E + +E L + ES Q E E E
Sbjct: 952 LEEQQGRQFCSTQAA--LQAMEREAE-QMGNELERLRAALMES---QGQQQEERGQQERE 1005
Query: 1516 VAKTNE----MQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQ 1571
VA+ + Q L ++ L + N N R + +Q+ ++ A K+G+D++
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
Query: 1572 L 1572
L
Sbjct: 1066 L 1066
Score = 80.2 bits (189), Expect = 6e-14
Identities = 191/1010 (18%), Positives = 416/1010 (41%), Gaps = 86/1010 (8%)
Query: 638 DEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA-SKKELALVIENLKL----DKEQ- 691
DE+E +LA+ +L +++ + + ++++ID L+ ++K+ A +E +L DK +
Sbjct: 231 DELELELAENRKLLTEK---DAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNES 287
Query: 692 ----LYGTIK---DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINH--E 742
L+ T+K DL+ +K + K+ +EN DL+ KL + A + +L +N E
Sbjct: 288 LTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREF-ASHLQQLQDALNELTE 346
Query: 743 EQSKIQTQFGIDAKIQERDLYIENIESELS-KYKSRICRLEESIAVMEDRRYSLERKADQ 801
E SK TQ ++ + Q +E ELS + + C LEE +++ + LE Q
Sbjct: 347 EHSK-ATQEWLEKQAQ--------LEKELSAALQDKKC-LEEKNEILQGKLSQLEEHLSQ 396
Query: 802 L-GSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK--QLLEIEHENKE--LQKKNQ 856
L + QEK + + +Q + L A L ++ ++ ++LE E +E L +
Sbjct: 397 LQDNPPQEKGEVLGD-VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Query: 857 ILLEENQNLQISLSDMQQHYNALVE-KANRTDLAESESTKYQTQLRDLESNLKRITHEHQ 915
EE Q L ++D+Q + L + K +++ + Q+ L S L +
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL----N 511
Query: 916 TLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLN 975
I Q+ +E+ L+ + A + L + ++ + L Q+++ ++++
Sbjct: 512 ATIQQQDQELAGLK-------QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564
Query: 976 MNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINE----INKLNALLKQKDEEIIALNQK 1031
++E+ + H Q+ T + + E + E + +L AL K+K ++ L Q+
Sbjct: 565 QQLKEVAEKQEATRQDHAQQLATAAEE-REASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 1032 I---NNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ N A+ S + V+ + + A+ + K+E ++ ++ ++ +++ EL++ +R +
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE 683
Query: 1089 DDQIKELKETKLTFEMNIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ E + + + + + + T + ++ LK +
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
Query: 1147 E---EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
E+ +ER L+E+ A + +++QL + T +V+ +E + ++
Sbjct: 744 RSLVEQHKRERKELEEERA----GRKGLEARLLQLGEAHQAET--EVLRRELAEAMAAQ- 796
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL---RVQ 1260
+E + L+ VA R + Q + ++++ L + + +K EL + +
Sbjct: 797 HTAESECEQLVKEVAAWRDGYEDS-QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK 855
Query: 1261 LSAFESKYEQLLDSVQSSTQE-ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV--- 1316
++ ES E + Q+ E N ++QV + + Q + L LQEK A
Sbjct: 856 VAGIESHSELQISRQQNKLAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 915
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENA- 1375
+ ++E L + +++ + E Q + Q+ L E A
Sbjct: 916 VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Query: 1376 ----QLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEI-YQKTHEYTITLTQR 1430
+L++ E +V LT + +++ +K + + +
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEE 1490
N E + E LT ++ + + +L+ E A E + ++++K E+
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLK--EQ 1093
Query: 1491 LNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRAS 1550
L K E S + +E E K ++ + E + ++ +L+ + A
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
Query: 1551 SSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAELDLAMYMLHQRD 1600
+ + S A +T QG+ E+ + A+ A+ +LA + +D
Sbjct: 1154 RASRAERDS-ALETLQGQLEEKAQELGHS-QSALASAQRELAAFRTKVQD 1201
Score = 78.6 bits (185), Expect = 2e-13
Identities = 251/1422 (17%), Positives = 567/1422 (39%), Gaps = 119/1422 (8%)
Query: 212 EDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEH 271
+ + + ++ E EW +++ +L K++ + LEE N++L+ ++ EH
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE-EH 393
Query: 272 SKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELL 331
Q+ KQ T+++ + +E+ ++ +LL
Sbjct: 394 LSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR--VEMLETERGQQEAKLL 451
Query: 332 EHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSS 391
+ ++L + + + + +S +K+ S+ G +++ S S+L+
Sbjct: 452 AERG-HFEEEKQQLSSLITDLQSSISNLSQ-AKEELEQASQAHGARLTAQVASLTSELT- 508
Query: 392 ETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQ 451
TLN ++ E+A L+ + L + +++ + L +
Sbjct: 509 -TLNATIQQQ--DQELAGLKQQAKEKQAQLAQ---TLQQQEQASQGLRHQV---EQLSSS 559
Query: 452 LQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSA--- 508
L+ + QQ E T + ++A E+ + L + + + +EK K+A
Sbjct: 560 LKQKEQQLKEVAEK-QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
Query: 509 --EEQITQLNDEIDAANKNMIKV---KSNHKLKLKQMQKTIDNF-SKVSDSNKEIVRLTE 562
++Q+ N+ D+A ++ + K+ K++++Q ++ + ++ ++ L
Sbjct: 619 ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
Query: 563 ELHHLSQKVAELE---EEKGNLQLHLVDY-DSGRMIESDVYKKMIEMENLAETRLKAISL 618
+L QK E E +EK LQ L +S ++ + + ++ + E + + IS
Sbjct: 679 QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE 738
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
L+++ LV++ H ++K E+E++ A L++ + ++ H + + + L E
Sbjct: 739 LKAETRSLVEQ-HKRERK--ELEEERAGRKGLEARLL--QLGEAH-QAETEVLRRELAEA 792
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNY---IQEN-MDLTDKLEKMSAE--KI 732
+ + EQL + + ED + Y QE M L ++ EK E +
Sbjct: 793 MAAQHTAESECEQLVKEVAAWRDGYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA 852
Query: 733 SELLAKINHEEQSKIQTQFGIDA-----------KIQERDLYIENIESELSKYKSRICRL 781
E +A I + +I Q A ++QE+++ + + +LS + ++
Sbjct: 853 KEKVAGIESHSELQISRQQNKLAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
Query: 782 EESIAVMEDR-RYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQ 840
+ +A +E R + E++ ++E +A +E R ++
Sbjct: 913 SKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR--QFCSTQAALQAM 970
Query: 841 LLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANR--TDLAESESTKYQT 898
E E EL++ L+E Q ++ L ++ R DLA ++ + +
Sbjct: 971 EREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL 1030
Query: 899 QLRDLESNLKRITHEHQTL-----IVQKKKEIEDLEIEFNTQIESA-IRDKKVLNEKYEK 952
++R L++ L E TL +KE +D E+ +E+A I++ + L + ++
Sbjct: 1031 EMR-LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
Query: 953 NIEYVTQLEAQ-------LQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
E + + E + E E +E L + + +++ QKQQ Q+ D E
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL-RAEVSKLEQQCQKQQEQA-DSLE 1147
Query: 1006 QYINEINKLNALLKQKDEEII--ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEE 1063
+ + E + + + E + L +K S S ++ + +LA F TK+++ +
Sbjct: 1148 RSL-EAERASRAERDSALETLQGQLEEKAQELGHS-QSALASAQRELAAFRTKVQDHSKA 1205
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
Q+ +Q E L+ ++++ L L E + + ++++ S+
Sbjct: 1206 EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAE-----SE 1260
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT 1183
+ ++ V E +Q ++L + + + +E + + E L
Sbjct: 1261 KSQKLEESCACCRQRQPA-TVPE----LQNAALLCGRRCRASG--REAEKQRVASENLRQ 1313
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL 1243
ELT +E +LK+ E+ + + LST+ +L + + A+ L +Q
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKF-FQKEQALSTL-QLEHTSTQALVSELLPAKHLCQQLQ 1371
Query: 1244 AQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE 1303
A++ A ++ EL A +LL Q E +++ + Q + Q +
Sbjct: 1372 AEQAAAEKRHREELEQSKQAAGGLRAELL-----RAQRELGELIPLRQKVAEQER---TA 1423
Query: 1304 EHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ 1363
+ LR + YA+ ++ ++ + +E ++ + K +Q
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAEEN-----RGLGERANLGRQFLEVELDQAREKYVQ 1478
Query: 1364 EQSILNINEEN--AQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTH 1421
E + + + E A++++ + + A+ KVLE + + + ++ +
Sbjct: 1479 ELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1538
Query: 1422 EYTITLTQRNDEFENVRQQLVEY------EKRIEDLTYEKESELAILRLKMHENANHYET 1475
E + L +D+ V+QQ ++ E + E ++ + +L E A +
Sbjct: 1539 ELSKKLAD-SDQASKVQQQKLKAVQAQGGESQQEAQRFQAQLNELQAQLSQKEQAAEHYK 1597
Query: 1476 MQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT-NEMQTA-LENQEIEI 1533
+Q E ++ N ++ E + +Q+ + NK L E + +E+Q A L+ +E E
Sbjct: 1598 LQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQ 1657
Query: 1534 VT--LNDEITNLQNMVRASSSKIQKHVSF--ASDTKQGRDEQ 1571
L ++ +L+ V + +++ F A+D + R+ Q
Sbjct: 1658 TCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQ 1699
Score = 73.3 bits (172), Expect = 6e-12
Identities = 252/1388 (18%), Positives = 523/1388 (37%), Gaps = 103/1388 (7%)
Query: 72 KEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQYKELSKRSSTTIVRXXXXXXX 131
+EH KAT E L + + + L+ L+ K+ L EK E+ + + +
Sbjct: 346 EEHSKATQEWLEKQ--AQLEKELSAALQDKKCLEEK----NEILQGKLSQLEEHLSQLQD 399
Query: 132 XXXXXXXXQLGDVTHLSNTIKEKDNALSV----LQVKMKIMETTILDLQEKINEKDQIIE 187
LGDV L T+K++ L+ LQ +++++ET + K+ + E
Sbjct: 400 NPPQEKGEVLGDVLQLE-TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 188 AKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKD 247
+ + + E+ +Q A A E L I+ +D
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 248 VRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK 307
++ L++ K +A + + + +Q L K+ E +E
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK--QEA 576
Query: 308 TEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGS 367
T + L A E + + Q+ KE KL + + + +
Sbjct: 577 TRQDHAQQLATA-AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQ 635
Query: 368 PLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYV 427
+++ K Q ET Q+ + + ++A+LE+ ++S + +KE V
Sbjct: 636 TSVTQAQREKAELSRKVEELQACVETARQEQHEA--QAQVAELELQLRSEQQKATEKERV 693
Query: 428 ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQ 487
EKD QLQ E Q ++ + G+ E+ A E+ +Q
Sbjct: 694 AQEKD------------------QLQ-EQLQALKESLKVTKGSLEEEKRRAADALEE-QQ 733
Query: 488 ELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNF 547
E+K + L+E+ K +++ + ++++ H+ + + +++ +
Sbjct: 734 RCISELK-AETRSLVEQHKRERKELEEERAGRKGLEARLLQLGEAHQAETEVLRRELAEA 792
Query: 548 SKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN 607
+ + E L ++VA + + Q Y G M + + E E
Sbjct: 793 MAAQHTAES------ECEQLVKEVAAWRDGYEDSQQEEAQY--GAMFQEQLMTLKEECEK 844
Query: 608 LAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLAD-ISQLQSDQVCSEIKSVHLEE 666
+ +A + + ++ Q K E+ LA + Q+Q +V ++ + L
Sbjct: 845 ARQELQEAKEKVAGIESHSELQISRQQNKLAELHANLARALQQVQEKEVRAQKLADDLST 904
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK 726
+ ++A+ KE+A + ++ EQ ++L + ++ +++E
Sbjct: 905 LQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG-RQFCST 963
Query: 727 MSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA 786
+A + E A+ E +++ ++++ Q+++ + E E+++ R + +A
Sbjct: 964 QAALQAMEREAEQMGNELERLRAAL-MESQGQQQEERGQQ-EREVARLTQERGRAQADLA 1021
Query: 787 VMEDRRYSLE-RKADQLGSYLQE---KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLL 842
+ + R LE R + L E Q+A + +++ LA L + K+L
Sbjct: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
Query: 843 EIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVE------KANRTDLA--ESEST 894
E+ K+L K Q+ +E ++ S S Q E +A R +++ E +
Sbjct: 1082 ELRQTVKQL--KEQLAKKEKEHA--SGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137
Query: 895 KYQTQLRDLESNLK--RITH-EHQTLIVQKKKEIEDLEIEFN---TQIESAIRDKKVLNE 948
K Q Q LE +L+ R + E + + + ++E+ E + + SA R+
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
K + + + + +AQ+ + E N + L + + ++++ V +++ +S + +
Sbjct: 1198 KVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEE-EVSILNRQVLEKEGESKELKRLVM 1256
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTK-LENMEEEMQRV 1067
E K QK EE A ++ A V + + + + + + E + +
Sbjct: 1257 AESEK-----SQKLEESCACCRQRQPATVPELQNAALLCGRRCRASGREAEKQRVASENL 1311
Query: 1068 SKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
++L + EEL ++ ++ + ++ T ++ T+ ++ S + P
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV--SELLPAKHLCQQ 1369
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTG 1187
+ Q ++ R+ L +L EL K+ + E +L
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG-ELIPLRQKVAEQERTAQQLRA 1428
Query: 1188 HDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQ-RGFEIAELW------K 1240
EQ++ LK L EN L R + +DQ R + EL +
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488
Query: 1241 QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQ 1300
LA+ + + Q T EL V + +E ++L+ Q QEE K+ QV L KL
Sbjct: 1489 TRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRF-QEERQKLTA--QVEELSKKLA 1545
Query: 1301 DKEEHLRNLQEKYADVI-----NQIEILRSEIE-DEKVAFXXXXXXXXXXXXXXXXDLRT 1354
D ++ + Q+K V +Q E R + + +E A +T
Sbjct: 1546 DSDQASKVQQQKLKAVQAQGGESQQEAQRFQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1605
Query: 1355 ENQSYKQ----MQEQ--SILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQ 1408
+ KQ +QEQ S+ + +EN +L+ + + +AE LT Q
Sbjct: 1606 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1665
Query: 1409 LELKDSEI 1416
+ ++++
Sbjct: 1666 VRSLEAQV 1673
Score = 62.5 bits (145), Expect = 1e-08
Identities = 103/535 (19%), Positives = 226/535 (42%), Gaps = 44/535 (8%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQI-------LVREQDDQIKELKE--TKLTFEMNIP 1107
L+ + +M+R+ KQL D + + +EL++ L+ E+D QI +++ +L +N
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL-LNEK 267
Query: 1108 KTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTE 1167
+ + +E + D ++ LK E+ + ++ + L E++ L+ +
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT-EKSQMDRKINQLSEENGDLSFK 326
Query: 1168 LQECYTKIIQLETLNTELT-GHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISS 1226
L+E + + QL+ ELT H QE + K QL E LS + + +
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWL----EKQAQLEKE----LSAALQDKKCLEE 378
Query: 1227 AVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETN-K 1285
+ ++++L ++HL+Q + + + + E+ + E+ ++ ++TQ + +
Sbjct: 379 KNEILQGKLSQL-EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
Query: 1286 IVTMEQVTSLQNKLQDK---EEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
++ E+ L ++ EE + L D+ + I L E+ + A
Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNI----NEENAQLKKSSXXXXXXXXXXXXRVNDA 1398
+L T N + +Q Q+Q + + E+ AQL ++ +V
Sbjct: 498 AQVASLTSELTTLNATIQQ-QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQL 556
Query: 1399 EAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESE 1458
+ + + QL+ + ++ L +E E ++ K++E L EK ++
Sbjct: 557 SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAK 616
Query: 1459 LAILRLKM---HENANHYETMQKESEIERVKL---IEELNVKI----TESVSLNKQVAEL 1508
L IL+ ++ +E + +T +++ E+ +L +EEL + E QVAEL
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL 676
Query: 1509 NKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASD 1563
L E K E + + ++ L +++ L+ ++ + +++ A+D
Sbjct: 677 ELQLRSEQQKATEKERVAQEKD----QLQEQLQALKESLKVTKGSLEEEKRRAAD 727
>D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein.
Length = 1388
Score = 83.8 bits (198), Expect = 5e-15
Identities = 135/696 (19%), Positives = 292/696 (41%), Gaps = 48/696 (6%)
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
K++ L E L + Q ELE++ ++ L + + + E +K +E R K
Sbjct: 447 KKLYTLEEHLSNEMQAKEELEQKCKSVNTRL-EKTAKELEEEITLRKSVESALRQLEREK 505
Query: 615 AISLLESQKFDL-----VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
A+ ++ ++ + L+ + ++D+L D+ + + S K L+ Q+D
Sbjct: 506 ALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLD 565
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK--- 726
+A + + L+ + + I+ LE++ D+ +K N + E L KLEK
Sbjct: 566 ETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDK--NCLLETAKL--KLEKEFI 621
Query: 727 -MSAEKISELLAKINHEE-QSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEE 783
+ + SE + + E + +Q + G++ ++ + + +E E + + R LE+
Sbjct: 622 NLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEK 681
Query: 784 SIAVME-DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL-AVLMDHDRVVEKQL 841
+ ME D Y L + Q + + KA ++++ + + + +EK+L
Sbjct: 682 EKSNMEIDMTYQL-KVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKL 740
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE------STK 895
LE E QK +LLE + + D++Q + E + D+ + +
Sbjct: 741 LE---ERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIE 797
Query: 896 YQTQLRDLESN-LKRITHEHQTLIVQKKKEIED----LEIEFNTQIESA-IRDKKVLNEK 949
+TQ R L N LK T + TL + +K+ ++ +E++ N + ++A +R ++ +
Sbjct: 798 QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 857
Query: 950 YEKNIEYVTQLEAQLQE-YKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQSPDYTEQ 1006
K ++ + E YK + L EE K+ EL K +Q ++ E
Sbjct: 858 QMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEI 917
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ + + +E+ L ++ ++ M++ ++ +L + + ++EE +
Sbjct: 918 TLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRT 977
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLT-------FEMNIPKTEGMIISSTIE 1119
++ + + EEL +++ +Q+ LK+ +++ FE + TE + + +
Sbjct: 978 LTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQL-LTERTLKTQAVN 1036
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKII 1176
+++ N + + + + E ER L +Q K EL E +I
Sbjct: 1037 KLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA 1096
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+ + EL I QL+S+L+ L+ D+
Sbjct: 1097 EESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDS 1132
Score = 77.8 bits (183), Expect = 3e-13
Identities = 127/714 (17%), Positives = 292/714 (40%), Gaps = 49/714 (6%)
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
+E D E + + ++ LEE ++ + LE+K + + L++ K
Sbjct: 429 RENDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKEL---- 484
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
E+E+ R +V R +E++ ++H+N E Q+K ++ +NL+ ++ ++
Sbjct: 485 --EEEITLRKSV-ESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLE 541
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
L ++ + ++ + + Q QL + + L+ T ++K + +I+
Sbjct: 542 DLKKRNQNSQISTEKVNQLQRQLDETNALLR--TESDTAARLRKTQAESSKQIQQLESNN 599
Query: 938 SAIRDKKVLNE----KYEKN-IEYVTQLEAQLQEYKNNIENLN------MNVEE-LNKMN 985
++DK L E K EK I + LE++ ++ + E +N +EE L
Sbjct: 600 RDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGK 659
Query: 986 LELIDKHVQKQQTQS--PDYTEQYIN-------EINKLNALLKQKDEEIIALNQKINNAQ 1036
+ L ++K+Q Q D ++ N ++ + L+Q++ E A ++ +
Sbjct: 660 ILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKN 719
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
Y S+ + + KL Q+V LL++++ L +++ +I EL
Sbjct: 720 KIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELL 779
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEP--MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
+ K ++ I T + +D LK QE ++ +
Sbjct: 780 KQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLK-QENNHLMEMK 838
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
L++Q+A+L E Q+ ++ +L+ + + Q+ +LK + E+ L
Sbjct: 839 MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQ 898
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLA-----QREADFQKTEHELRVQLSAFESKYE 1269
EL+ S Q + + + LA ++ +D +K + +++ ++++
Sbjct: 899 QKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK 958
Query: 1270 QLLDSVQS--STQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
Q L + ++ EETN+ +T + V +L N+ ++ L+++QE+ + + ++ EI + I
Sbjct: 959 QELTEKDATIASLEETNRTLTSD-VANLANEKEELNNKLKDVQEQLSRLKDE-EISAAAI 1016
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
+ + ++ + K+ + + +EN +L
Sbjct: 1017 KAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHME------- 1069
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
++ K + ++++ + +E Q E +TL ++ + E +R QL
Sbjct: 1070 LKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1123
Score = 76.2 bits (179), Expect = 9e-13
Identities = 152/730 (20%), Positives = 315/730 (43%), Gaps = 71/730 (9%)
Query: 299 SIEPSCEEKTEIEEKGSLEIANMTELTKKIELL-EHLNCQIRQTNKELENKLATMGTESK 357
S PSC E I+ + + E E+ KK+ L EHL+ ++ Q +ELE K ++ T +
Sbjct: 423 SDSPSCRENDSIQSRKNEE---SQEIQKKLYTLEEHLSNEM-QAKEELEQKCKSVNTRLE 478
Query: 358 AVSSPSKKGSPL-ISRKSGRNTASKMKSPWSQLSSE---TLNQDTDKKIN-KNEIAKLEM 412
+ ++ L S +S + K+ ++E + + DKK N +N++ L+
Sbjct: 479 KTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD 538
Query: 413 VIQSLNK----DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
++ L K + E V + DT +L Q + +
Sbjct: 539 QLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDT---AARLRKTQAESSKQIQQL 595
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK----SAEEQITQLNDEIDAANK 524
+N D+ + + E K +L E +N++ +E + E I L I +
Sbjct: 596 ESNNRDLQDKNCLLETAKLKLEKEF--INLQSALESERRDRTHGSEIINDLQGRICGLEE 653
Query: 525 NMIKVK---SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
++ K + +L+ +Q+Q+ + K SN EI +T +L + Q + + E E
Sbjct: 654 DLKNGKILLAKVELEKRQLQERFTDLEK-EKSNMEI-DMTYQLKVIQQSLEQEEAEHKAT 711
Query: 582 QLHLVD----YDSGRMIES----DVYKKMIE-------MENLAETRLKAISLLESQKFDL 626
+ L D Y+S +S ++ KK++E +ENL K SLL+
Sbjct: 712 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 771
Query: 627 VQELHILQQKYDEVEDKLADIS---QLQSDQVCSEIKSVHLE-EQIDALSASKKELALVI 682
Q+++ L ++ D + + + +++ + ++ + C + ++ +Q++ L S+K+L
Sbjct: 772 QQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQEN 831
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
+L K L +L +++D +++ +Q+ ++ + ++ EL K E
Sbjct: 832 NHLMEMKMNLEKQNAELRKERQDADGQMKE-LQDQLEAEQYFSTLYKTQVREL--KEECE 888
Query: 743 EQSKI--QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E++K+ + Q ERD +E L+K S +L SIA E++ LE++
Sbjct: 889 EKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE--QLARSIA--EEQYSDLEKEKI 944
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
++E + + ++D + A L + +R + + + +E +EL K L+
Sbjct: 945 MKELEIKEMMARHKQELTEKDATI---ASLEETNRTLTSDVANLANEKEELNNK----LK 997
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAE-SESTKYQTQLRDLESNLKRITHEHQTLIV 919
+ Q L D + A+ + + L E + T+ +L ++ + + + + T +
Sbjct: 998 DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1057
Query: 920 QKKKEIEDLEIEFNTQIE----SAIRDKKVLNE---KYEKNIEYVTQLEAQLQEYKNNIE 972
+K+KE L +E ++ E I+ +K LNE + + + +L+ L ++IE
Sbjct: 1058 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1117
Query: 973 NLNMNVEELN 982
L ++ L+
Sbjct: 1118 QLRSQLQALH 1127
Score = 74.5 bits (175), Expect = 3e-12
Identities = 123/633 (19%), Positives = 251/633 (39%), Gaps = 54/633 (8%)
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN-KLNALLKQKDEEII------- 1026
N +E+ K L +++H+ + Q+ + EQ +N +L K+ +EEI
Sbjct: 439 NEESQEIQK-KLYTLEEHLSNEM-QAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVES 496
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVR 1086
AL Q + + ++Y+ K K N+E ++ + QL D K+ N+ QI
Sbjct: 497 ALRQ-LEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTE 555
Query: 1087 EQDDQIKELKETKL---TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK 1143
+ + ++L ET T + S+ + ++NN D LK
Sbjct: 556 KVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK 615
Query: 1144 VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
+ E+EFI +S L+ + + E +N +L G +E + K L
Sbjct: 616 L--EKEFINLQSALESERRD----------RTHGSEIIN-DLQGRICGLEEDLKNGKILL 662
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL----RV 1259
++ E L +L S+ +++ + +Q L Q EA+ + T+ L ++
Sbjct: 663 AKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVI-QQSLEQEEAEHKATKARLADKNKI 721
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
S E+K E + + + +E T K + + + + L+ Q+K +++ Q
Sbjct: 722 YESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQ 781
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
++L ++ + DL+ + Q ++ S + +EN L +
Sbjct: 782 KDVLNEDVRN----LTLKIEQETQKRCLTQNDLKMQTQQVNTLK-MSEKQLKQENNHLME 836
Query: 1380 SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQ 1439
DA+ ++ EL QLE +E Y T Y + + +E E +
Sbjct: 837 MKMNLEKQNAELRKERQDADGQMKELQDQLE---AEQYFSTL-YKTQVRELKEECEEKTK 892
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKM----HENANHYETMQKESEIERVKLIEELNVK- 1494
E +++ ++L E++S A L + + E ++ S++E+ K+++EL +K
Sbjct: 893 LGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKE 952
Query: 1495 --------ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
+TE + + E N+ L +VA + L N+ ++ + + +
Sbjct: 953 MMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEIS 1012
Query: 1547 VRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
A ++ +K + K +L MN++
Sbjct: 1013 AAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK 1045
Score = 64.5 bits (150), Expect = 3e-09
Identities = 137/697 (19%), Positives = 289/697 (41%), Gaps = 65/697 (9%)
Query: 847 ENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT--DLAESESTK--YQTQLRD 902
E++E+QKK L E N + +++Q ++ + +T +L E + + ++ LR
Sbjct: 441 ESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQ 500
Query: 903 LESNLKRITH---EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
LE + H E+Q + + +LE + N+ ++ + D K N+ + + E V Q
Sbjct: 501 LEREKALLQHKNAEYQRKADHEADKKRNLENDVNS-LKDQLEDLKKRNQNSQISTEKVNQ 559
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI----------N 1009
L+ QL E + + L K E K +Q+ ++ + D ++
Sbjct: 560 LQRQLDETNALLRTESDTAARLRKTQAES-SKQIQQLESNNRDLQDKNCLLETAKLKLEK 618
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENMEEEMQR 1066
E L + L+ + + ++ IN+ Q + D ++ LA+ + ++E
Sbjct: 619 EFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTD 678
Query: 1067 VSKQLLDSK-QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD-D 1124
+ K+ + + +L+++ + + + E K TK + K I + E M + +
Sbjct: 679 LEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLA-DKNKIYESIEEAKSEAMKEME 737
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFI--------QERSVLQEQSAKLNTELQECYTKII 1176
++ L+ ++ + Q+ + L +Q LN +++ KI
Sbjct: 738 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIE 797
Query: 1177 QLETLNTELTGHDVVNQ-EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR---G 1232
Q ET LT +D+ Q +Q+N LK +QL EN++L+ L + +R
Sbjct: 798 Q-ETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDAD 856
Query: 1233 FEIAELWKQHLAQRE-ADFQKTE-HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME 1290
++ EL Q A++ + KT+ EL+ + ++K + L + Q+E + +
Sbjct: 857 GQMKELQDQLEAEQYFSTLYKTQVRELKEECEE-KTKLGKELQQKKQELQDERDSLAAQL 915
Query: 1291 QVTSLQNKLQDKEEHLRNL-QEKYAD-----VINQIEI----LRSEIE-DEKVAFXXXXX 1339
++T + D E+ R++ +E+Y+D ++ ++EI R + E EK A
Sbjct: 916 EITLTK---ADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE 972
Query: 1340 XXXXXXXXXXXDLRTE----NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
+L E N K +QEQ + + +E
Sbjct: 973 ETNRTLTSDVANLANEKEELNNKLKDVQEQ-LSRLKDEEISAAAIKAQFEKQLLTERTLK 1031
Query: 1396 NDAEAKVLELTHQLEL----KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
A K+ E+ ++ E D+++ +K E + E E + QQ+++Y+K + ++
Sbjct: 1032 TQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEM 1091
Query: 1452 TYEKESELAI-LRLKMHENANHYETMQKESEIERVKL 1487
+ E I + L+M ++ + Q S+++ + +
Sbjct: 1092 QAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHI 1128
Score = 48.4 bits (110), Expect = 2e-04
Identities = 107/523 (20%), Positives = 215/523 (41%), Gaps = 44/523 (8%)
Query: 220 KMQENFI----AMEAEWKDEKQ--RLLKDIESKDVRISSLEEANKLLEAARFEISLEHSK 273
K+++ FI A+E+E +D ++ D++ RI LEE K + ++ LE +
Sbjct: 615 KLEKEFINLQSALESERRDRTHGSEIINDLQG---RICGLEEDLKNGKILLAKVELEKRQ 671
Query: 274 LAQ---ELEQXXXXXXXXXXXXXXLAKQSIEPSCEE----KTEIEEKG----SLEIAN-- 320
L + +LE+ + +QS+E E K + +K S+E A
Sbjct: 672 LQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSE 731
Query: 321 -MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT- 378
M E+ KK+ L ++ E E + + + + K +K + L+ +K N
Sbjct: 732 AMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLK---QSQQKINELLKQKDVLNED 788
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL---NKDLVDKEYVISEKDTXX 435
+ Q + + D K+ ++ L+M + L N L++ + + +++
Sbjct: 789 VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAEL 848
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDE 492
G+ + Q QLE +Q+ V E+ E K+ ++L KQEL DE
Sbjct: 849 RKERQDADGQMKEL-QDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDE 907
Query: 493 IKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+ + I K+ EQ+ + + ++ K K +L++K+M + ++++
Sbjct: 908 RDSLAAQLEITLTKADSEQLAR--SIAEEQYSDLEKEKIMKELEIKEMMAR--HKQELTE 963
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS--GRMIESDVYKKMIEMENLAE 610
+ I L E L+ VA L EK L L D R+ + ++ I+ + E
Sbjct: 964 KDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQ--FE 1021
Query: 611 TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH--LEEQI 668
+L L++Q + + E+ ++ D + ++ ++ E+KS L +Q+
Sbjct: 1022 KQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQM 1081
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
E+ I + +L T+ ++D E + ++LQ
Sbjct: 1082 IKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQ 1124
Score = 35.5 bits (78), Expect = 1.6
Identities = 53/261 (20%), Positives = 107/261 (40%), Gaps = 15/261 (5%)
Query: 160 VLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMT 219
V ++K + E T L +++ +K Q ++ + + ++Q +
Sbjct: 880 VRELKEECEEKT--KLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYS 937
Query: 220 KMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE 279
+++ I E E K+ R +++ KD I+SLEE N+ L + ++ E +L +L+
Sbjct: 938 DLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLK 997
Query: 280 QXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN-MTELTKKIELLEHLN-CQ 337
A +I+ E++ E + N + E+ + E ++ N
Sbjct: 998 DVQEQLSRLKDEEISAA--AIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTD 1055
Query: 338 IRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQD 397
+R+ KE EN+ M +S+ K +I + N + SQ+ E L
Sbjct: 1056 VRR--KEKENRKLHMELKSER----EKLTQQMIKYQKELNEMQAQIAEESQIRIE-LQMT 1108
Query: 398 TDKKINKNEIAKLEMVIQSLN 418
D K ++I +L +Q+L+
Sbjct: 1109 LDSK--DSDIEQLRSQLQALH 1127
Score = 33.1 bits (72), Expect = 8.5
Identities = 71/359 (19%), Positives = 140/359 (38%), Gaps = 32/359 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQ--VKMKIMETTILDLQEKI--NEKDQIIEAKNKATTXXXX 198
DV +L+ I+++ + Q +KM+ + L + EK E + ++E K
Sbjct: 788 DVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAE 847
Query: 199 XXXXXXXXXXXXXE-----DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSL 253
E + +Q + + + + E +EK +L K+++ K +
Sbjct: 848 LRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQ-- 905
Query: 254 EEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSI-EPSCEEKTEIEE 312
+E + L AA+ EI+L + Q + + I E K E+ E
Sbjct: 906 DERDSL--AAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTE 963
Query: 313 K----GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTES-KAVSSPSKKGS 367
K SLE N T LT + L + ++ K+++ +L+ + E A + ++
Sbjct: 964 KDATIASLEETNRT-LTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEK 1022
Query: 368 PLISRKSGRNTA-SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS---------- 416
L++ ++ + A +K+ ++ DTD + + E KL M ++S
Sbjct: 1023 QLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMI 1082
Query: 417 -LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
K+L + + I+E+ KD+ I QL+ + Q G +G+ D
Sbjct: 1083 KYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGD 1141
>AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein.
Length = 948
Score = 83.8 bits (198), Expect = 5e-15
Identities = 134/682 (19%), Positives = 286/682 (41%), Gaps = 65/682 (9%)
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
KEL L+ + L+ + E T K N +++ + KL +Q L + E+ E
Sbjct: 279 KELFLLRKTLE-EMELRIETQKQTLNARDESIKKLLEMLQSK-----GLSAKATEEDHER 332
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIES--ELSKYKSRICRLEESIAVMEDRRY 793
++ E + ++ K +E + E + E + ++ L+ I + + +
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 794 SLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQK 853
S+ER L +Q + + T + +E + ++ V H + ++ ++ +++ E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 854 KNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHE 913
+ L + + L SD +QH L E E + QT++ L L+ E
Sbjct: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAK---EQRAAILQTEVDALRLRLE----E 505
Query: 914 HQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIEN 973
+T++ +K K+I+D+ E TQ I D K + + E+ + + + IEN
Sbjct: 506 KETMLNKKTKQIQDMAEEKGTQA-GEIHDLKDMLDVKERKVNVL----------QKKIEN 554
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKIN 1033
L + + K + + + V+ Q + + T+ + L L +K+ I L ++ +
Sbjct: 555 LQEQLRDKEKQ-MSSLKERVKSLQADTTN-TD---TALTTLEEALAEKERTIERLKEQRD 609
Query: 1034 NAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + +Y+ L K+ ++ ++ LLD K+H L ++D ++K
Sbjct: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
Query: 1094 EL-------KETKLTFEMNIPKTEGMIISSTIEP-MSDDANNVDXXXXXXXXXXXXLKVQ 1145
L KE L E + K + + P MSD +++ + +
Sbjct: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 729
Query: 1146 EEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS-- 1201
+ E ++E + K EL+ ++ Q++ N ++ ++ ++EQ+ + KS
Sbjct: 730 VDRLLEILKEVENEKNDKDKKIAELESLTSR--QVKDQNKKVA--NLKHKEQVEKKKSAQ 785
Query: 1202 KLEQLNTENDNLLSTVAELR-SSISSAVDQRGFEIAEL------WKQHLAQREADFQKTE 1254
LE+ DNL + +L+ + A+++ E+ + +Q LA++E
Sbjct: 786 MLEEARRREDNLNDSSQQLQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR 845
Query: 1255 HELRVQL-SAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQD-----KEEHLRN 1308
E R L E K E LL ++ ++++ N + + +++S + K Q+ K E R
Sbjct: 846 AERRKHLEEVLEMKQEALLAAI---SEKDAN--IALLELSSSKKKTQEEVAALKREKDRL 900
Query: 1309 LQEKYADVINQIEILRSEIEDE 1330
+Q+ N+++++ ED+
Sbjct: 901 VQQLKQQTQNRMKLMADNYEDD 922
Score = 63.7 bits (148), Expect = 5e-09
Identities = 121/657 (18%), Positives = 261/657 (39%), Gaps = 57/657 (8%)
Query: 900 LRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEY--V 957
+ DL++ LK + E+ L +K E+++ ++ + ++ E+ + E +
Sbjct: 151 IMDLQTQLKEVLRENDLL--RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
Query: 958 TQLEAQLQEYKNNIENLNMNVEELN-----KMNLELIDKHVQKQQTQSPDYTEQYINEIN 1012
T + Q + + +++ M ++ L + +L + + +T P E
Sbjct: 209 TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
Query: 1013 KLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---------EE 1063
+L+A +++ +E+ L + + ++ + ++ LE ++ EE
Sbjct: 269 RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
Query: 1064 MQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD 1123
+++L +++ H L+ L+ +++ + L+E N P + T+ M D
Sbjct: 329 DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD 388
Query: 1124 DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNT 1183
L+ EEE IQ + + + L+TE +E K Q+E +
Sbjct: 389 SK---------ISSMERGLRDLEEE--IQ----MLKSNGALSTEEREEEMK--QMEVYRS 431
Query: 1184 ELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHL 1243
H + +I Q+K +L + +TE LL+ +L + + D + + E+ K+ L
Sbjct: 432 ----HSKFMKNKIGQVKQELSRKDTE---LLALQTKLETLTNQFSDSK--QHIEVLKESL 482
Query: 1244 A---QREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSL----Q 1296
QR A Q LR++L E+ + +Q +E+ + + + + +
Sbjct: 483 TAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE 542
Query: 1297 NKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTEN 1356
K+ ++ + NLQE+ D Q+ L+ ++ + RT
Sbjct: 543 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE 602
Query: 1357 QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELT-HQLELKDSE 1415
+ K+ +++ EE KK +++ EA +L+L H L S
Sbjct: 603 R-LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 661
Query: 1416 IYQKTHEYT--ITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHY 1473
+ + + T I L Q+ +E + QL + + + E I L+
Sbjct: 662 LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 721
Query: 1474 ETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQE 1530
E+ + ++E++R L+E L E +K++AEL +V N+ L+++E
Sbjct: 722 ESSKAQAEVDR--LLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKE 776
Score = 63.7 bits (148), Expect = 5e-09
Identities = 143/726 (19%), Positives = 298/726 (41%), Gaps = 52/726 (7%)
Query: 837 VEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALV--EKANRTDLAESEST 894
++ QL E+ EN L+K ++ + L S++ ++ ++ + E+A R D A S+ T
Sbjct: 154 LQTQLKEVLRENDLLRKDVEV---KESKLSSSMNSIKTFWSPELKKERALRKDEA-SKIT 209
Query: 895 KYQTQLRDLESNLKRITHEHQTLIVQKKKEIE-DLEIEFNTQIESAIRDKKVLNEKYEKN 953
++ Q R ++ + + Q L Q + I+ DL F Q S+ + + E E+N
Sbjct: 210 IWKEQYRVVQEENQHMQMTIQAL--QDELRIQRDLNQLFQ-QDSSSRTGEPCVAELTEEN 266
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
+ +L A+ + + L +EE+ ++ +E QKQ + D + + + E+ +
Sbjct: 267 FQ---RLHAEHERQAKELFLLRKTLEEM-ELRIE-----TQKQTLNARDESIKKLLEMLQ 317
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLD 1073
L + EE +++ A++ V ES L Q + + EEM R + D
Sbjct: 318 SKGLSAKATEEDHERTRRLAEAEMH----VHHLESLLEQKEKENSMLREEMHRRFENAPD 373
Query: 1074 SKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXX 1133
S + + LQ ++ +D +I ++ E I + ST E ++ ++
Sbjct: 374 SAK-TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALST-EEREEEMKQMEVYRS 431
Query: 1134 XXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHD---V 1190
+ Q ++E ++ + L KL T + +E L LT +
Sbjct: 432 HSKFMKNKIG-QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 490
Query: 1191 VNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ-HLAQREAD 1249
+ Q +++ L+ +LE E + +L+ + ++ + EI +L + +R+ +
Sbjct: 491 ILQTEVDALRLRLE----EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 546
Query: 1250 -FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
QK L+ QL E + L + V+S + TN T +T+L+ L +KE +
Sbjct: 547 VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN---TDTALTTLEEALAEKERTIER 603
Query: 1309 LQEKY----ADVINQIEILRSEIED--EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM 1362
L+E+ + +I+ + +++D EKV+ + + S
Sbjct: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
Query: 1363 QEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHE 1422
++ + + Q K+ +A A E++ +++ + EI + E
Sbjct: 664 KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP-EMSDRIQHLEREITRYKDE 722
Query: 1423 YTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE----NANHYETMQK 1478
+ + + E +++ VE EK +D + L ++K N H E ++K
Sbjct: 723 SSKAQAEVDRLLEILKE--VENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEK 780
Query: 1479 ESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLND 1538
+ + ++ + +S S QV EL A+E+ + M+ L + + +
Sbjct: 781 KKSAQMLEEARRREDNLNDS-SQQLQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 839
Query: 1539 EITNLQ 1544
+TNL+
Sbjct: 840 HLTNLR 845
Score = 60.1 bits (139), Expect = 6e-08
Identities = 101/586 (17%), Positives = 242/586 (41%), Gaps = 35/586 (5%)
Query: 144 VTHLSNTIKEKDNALSVLQVKMKIMETTILD------LQEKINEKDQIIEAKNKATTXXX 197
V HL + +++K+ S+L+ +M D LQ I KD I + +
Sbjct: 343 VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLE 402
Query: 198 XXXXXXXXXXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEAN 257
E+ +++M +M E + + K++ ++ +++ KD + +L+
Sbjct: 403 EEIQMLKSNGALSTEEREEEMKQM-EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKL 461
Query: 258 KLLEAARFEISLEHSKLAQE---LEQXXXXXXXXXXXXXXLAKQSIEPSCEEKT-EIEEK 313
+ L +F S +H ++ +E ++ L + E +KT +I++
Sbjct: 462 ETL-TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 520
Query: 314 GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRK 373
+ E+ ++L+ ++ K++EN + + K +SS ++ L +
Sbjct: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADT 580
Query: 374 SGRNTA--------SKMKSPWSQLSSETLNQDTDKKIN----KNEIAKLEMVIQSLNKDL 421
+ +TA ++ + +L + + +K+ K ++ L+ + L DL
Sbjct: 581 TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 640
Query: 422 VDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKV 481
+KE + + KD+ + L++ +Q E + + + + +E A +
Sbjct: 641 SEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKE--ECLKMESQLKKAHE-AAL 697
Query: 482 QEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQ 541
+ + E++D I+ +++ I + K + D + K + K++ K+ +++
Sbjct: 698 EARASPEMSDRIQ--HLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 755
Query: 542 KTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKK 601
+V D NK++ L + +K A++ EE + +L DS + ++ V +
Sbjct: 756 SLTSR--QVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL--NDSSQQLQ--VEEL 809
Query: 602 MIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKS 661
++ ME + + + L S + L ++ L E L ++ +++ + + + I
Sbjct: 810 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE 869
Query: 662 VHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
+ LS+SKK+ + LK +K++L +K ++ +M
Sbjct: 870 KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLM 915
Score = 58.0 bits (134), Expect = 3e-07
Identities = 91/456 (19%), Positives = 189/456 (41%), Gaps = 21/456 (4%)
Query: 483 EQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQK 542
E L + +D + + V L E L + E++ L E+DA + + ++ K KQ+Q
Sbjct: 462 ETLTNQFSDSKQHIEV--LKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ- 518
Query: 543 TIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKM 602
D + EI L + L +KV L+++ NLQ L D + + K +
Sbjct: 519 --DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
Query: 603 IEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSV 662
+T L + ++K ++ L +Q+ + +K +I + D + K
Sbjct: 577 QADTTNTDTALTTLEEALAEKERTIERLK--EQRDRDEREKQEEIDNYKKDLKDLKEKVS 634
Query: 663 HLEEQIDALSAS---KKELALVIENLKLDKEQLYGTIK-DLENDKEDIMNKLQNYIQENM 718
L+ + AS KE A + + L K+ T++ LE KE+ + K+++ +++
Sbjct: 635 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL-KMESQLKKAH 693
Query: 719 D--LTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKS 776
+ L + +++I L +I + + Q +D ++ ++ +E+E +
Sbjct: 694 EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE----ILKEVENEKNDKDK 749
Query: 777 RICRLEE-SIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHD- 834
+I LE + ++D+ + + ++ + E +ED L + L +
Sbjct: 750 KIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQVEEL 809
Query: 835 -RVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESES 893
+EK E+E +L Q L E+ +L ++ ++H ++E LA
Sbjct: 810 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE 869
Query: 894 TKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
L +L S+ K+ E L +K + ++ L+
Sbjct: 870 KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLK 905
Score = 44.0 bits (99), Expect = 0.005
Identities = 97/522 (18%), Positives = 212/522 (40%), Gaps = 49/522 (9%)
Query: 51 QIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFVPGISESLANTLKQKEILMEKIKQ 110
Q+K E ++K E AL +K ++ ++ + + + ESL ++ IL ++
Sbjct: 442 QVKQELSRKDTELLALQTK-LETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTEVDA 498
Query: 111 YKELSKRSSTTIVRXXXXXXXXXXXXXXXQLGDVTHLSNTIKEKDNALSVLQVKMKIMET 170
+ L T++ Q G++ L + + K+ ++VLQ K++ ++
Sbjct: 499 LR-LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
Query: 171 TILDLQEK---INEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMTK----MQE 223
+ D +++ + E+ + ++A T E K+Q + QE
Sbjct: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
Query: 224 NFIAMEAEWKD--EKQRLLK-DIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQ 280
+ + KD EK LL+ D+ K+ + L+E L ++ + L LEQ
Sbjct: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 677
Query: 281 XXXXXXXXXXXXXXLAKQSIEP-SCEEKTEIEEKGSLEIANMTELTKKIE-----LLEHL 334
+ ++E + E ++ + EI + + K + LLE L
Sbjct: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 737
Query: 335 NCQIRQTNKELENKLATM-GTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSET 393
++ + + K+A + S+ V +KK + L ++ S ++ +
Sbjct: 738 K-EVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 796
Query: 394 LNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQ 453
LN D+ +++ ++ +L M ++ + ++L + +S K+T + L+
Sbjct: 797 LN-DSSQQL---QVEELLMAMEKVKQELESMKAKLSSTQQSLAE-------KETHLTNLR 845
Query: 454 LEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQIT 513
E ++H+ E+V E+ QE L ++++ ++ + +L K +E++
Sbjct: 846 AERRKHL------------EEVLEMK--QEALLAAISEKDANIALLELSSSKKKTQEEVA 891
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
L E D +K ++ +++KL D+F K S SN+
Sbjct: 892 ALKREKDRL-VQQLKQQTQNRMKLMADNYEDDHF-KSSHSNQ 931
Score = 37.9 bits (84), Expect = 0.30
Identities = 30/141 (21%), Positives = 66/141 (46%), Gaps = 4/141 (2%)
Query: 1410 ELKDSEIYQKTHEYTIT-LTQRNDEFENVRQQLVEYEKRIEDLTYE-KESELAILRLKMH 1467
E+K E+Y+ ++ + Q E +L+ + ++E LT + +S+ I LK
Sbjct: 422 EMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 481
Query: 1468 ENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALE 1527
A ++E++ ++L L K T KQ+ ++ + + + ++++ L+
Sbjct: 482 LTAKEQRAAILQTEVDALRL--RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLD 539
Query: 1528 NQEIEIVTLNDEITNLQNMVR 1548
+E ++ L +I NLQ +R
Sbjct: 540 VKERKVNVLQKKIENLQEQLR 560
Score = 36.3 bits (80), Expect = 0.91
Identities = 53/262 (20%), Positives = 106/262 (40%), Gaps = 17/262 (6%)
Query: 1355 ENQSYKQMQEQSILNINEENAQ-LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKD 1413
+ S + E + + EEN Q L + + E ++ L +D
Sbjct: 247 QQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 1414 SEI---YQKTHEYTITLTQRNDEFENVRQQLVEYEKRI---EDLTYEKESELAILRLKMH 1467
I + ++ ++ E R+ L E E + E L +KE E ++LR +MH
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 1468 ---ENA-NHYETMQKESEIE----RVKLIEELNVKITESVSLNKQVAELNKALEEEVAKT 1519
ENA + +T ++ IE ++ +E + E + + K L+ EE K
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 1520 NEMQTALEN-QEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLDNTMNK 1578
E+ + + +I + E++ + A +K++ + SD+KQ + ++ K
Sbjct: 426 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 485
Query: 1579 ELLDAVPRAELDLAMYMLHQRD 1600
E A+ + E+D L +++
Sbjct: 486 EQRAAILQTEVDALRLRLEEKE 507
>AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein.
Length = 1428
Score = 83.8 bits (198), Expect = 5e-15
Identities = 135/696 (19%), Positives = 292/696 (41%), Gaps = 48/696 (6%)
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
K++ L E L + Q ELE++ ++ L + + + E +K +E R K
Sbjct: 487 KKLYTLEEHLSNEMQAKEELEQKCKSVNTRL-EKTAKELEEEITLRKSVESALRQLEREK 545
Query: 615 AISLLESQKFDL-----VQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQID 669
A+ ++ ++ + L+ + ++D+L D+ + + S K L+ Q+D
Sbjct: 546 ALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLD 605
Query: 670 ALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEK--- 726
+A + + L+ + + I+ LE++ D+ +K N + E L KLEK
Sbjct: 606 ETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDK--NCLLETAKL--KLEKEFI 661
Query: 727 -MSAEKISELLAKINHEE-QSKIQTQF-GIDAKIQERDLYIENIESELSKYKSRICRLEE 783
+ + SE + + E + +Q + G++ ++ + + +E E + + R LE+
Sbjct: 662 NLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEK 721
Query: 784 SIAVME-DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL-AVLMDHDRVVEKQL 841
+ ME D Y L + Q + + KA ++++ + + + +EK+L
Sbjct: 722 EKSNMEIDMTYQL-KVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKL 780
Query: 842 LEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESE------STK 895
LE E QK +LLE + + D++Q + E + D+ + +
Sbjct: 781 LE---ERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIE 837
Query: 896 YQTQLRDLESN-LKRITHEHQTLIVQKKKEIED----LEIEFNTQIESA-IRDKKVLNEK 949
+TQ R L N LK T + TL + +K+ ++ +E++ N + ++A +R ++ +
Sbjct: 838 QETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 897
Query: 950 YEKNIEYVTQLEAQLQE-YKNNIENLNMNVEELNKMNLELIDK--HVQKQQTQSPDYTEQ 1006
K ++ + E YK + L EE K+ EL K +Q ++ E
Sbjct: 898 QMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEI 957
Query: 1007 YINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQR 1066
+ + + +E+ L ++ ++ M++ ++ +L + + ++EE +
Sbjct: 958 TLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRT 1017
Query: 1067 VSKQLLDSKQHNEELQILVREQDDQIKELKETKLT-------FEMNIPKTEGMIISSTIE 1119
++ + + EEL +++ +Q+ LK+ +++ FE + TE + + +
Sbjct: 1018 LTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQL-LTERTLKTQAVN 1076
Query: 1120 PMSDDANNVDXXXXXXXXXXXXLKVQEEE---EFIQERSVLQEQSAKLNTELQECYTKII 1176
+++ N + + + + E ER L +Q K EL E +I
Sbjct: 1077 KLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA 1136
Query: 1177 QLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
+ + EL I QL+S+L+ L+ D+
Sbjct: 1137 EESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDS 1172
Score = 77.8 bits (183), Expect = 3e-13
Identities = 127/714 (17%), Positives = 292/714 (40%), Gaps = 49/714 (6%)
Query: 758 QERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYT 817
+E D E + + ++ LEE ++ + LE+K + + L++ K
Sbjct: 469 RENDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKEL---- 524
Query: 818 IQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYN 877
E+E+ R +V R +E++ ++H+N E Q+K ++ +NL+ ++ ++
Sbjct: 525 --EEEITLRKSV-ESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLE 581
Query: 878 ALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIE 937
L ++ + ++ + + Q QL + + L+ T ++K + +I+
Sbjct: 582 DLKKRNQNSQISTEKVNQLQRQLDETNALLR--TESDTAARLRKTQAESSKQIQQLESNN 639
Query: 938 SAIRDKKVLNE----KYEKN-IEYVTQLEAQLQEYKNNIENLN------MNVEE-LNKMN 985
++DK L E K EK I + LE++ ++ + E +N +EE L
Sbjct: 640 RDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGK 699
Query: 986 LELIDKHVQKQQTQS--PDYTEQYIN-------EINKLNALLKQKDEEIIALNQKINNAQ 1036
+ L ++K+Q Q D ++ N ++ + L+Q++ E A ++ +
Sbjct: 700 ILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKN 759
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
Y S+ + + KL Q+V LL++++ L +++ +I EL
Sbjct: 760 KIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELL 819
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEP--MSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
+ K ++ I T + +D LK QE ++ +
Sbjct: 820 KQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLK-QENNHLMEMK 878
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
L++Q+A+L E Q+ ++ +L+ + + Q+ +LK + E+ L
Sbjct: 879 MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQ 938
Query: 1215 STVAELRSSISSAVDQRGFEIAELWKQHLA-----QREADFQKTEHELRVQLSAFESKYE 1269
EL+ S Q + + + LA ++ +D +K + +++ ++++
Sbjct: 939 QKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK 998
Query: 1270 QLLDSVQS--STQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
Q L + ++ EETN+ +T + V +L N+ ++ L+++QE+ + + ++ EI + I
Sbjct: 999 QELTEKDATIASLEETNRTLTSD-VANLANEKEELNNKLKDVQEQLSRLKDE-EISAAAI 1056
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
+ + ++ + K+ + + +EN +L
Sbjct: 1057 KAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHME------- 1109
Query: 1388 XXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQL 1441
++ K + ++++ + +E Q E +TL ++ + E +R QL
Sbjct: 1110 LKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1163
Score = 76.2 bits (179), Expect = 9e-13
Identities = 152/730 (20%), Positives = 315/730 (43%), Gaps = 71/730 (9%)
Query: 299 SIEPSCEEKTEIEEKGSLEIANMTELTKKIELL-EHLNCQIRQTNKELENKLATMGTESK 357
S PSC E I+ + + E E+ KK+ L EHL+ ++ Q +ELE K ++ T +
Sbjct: 463 SDSPSCRENDSIQSRKNEE---SQEIQKKLYTLEEHLSNEM-QAKEELEQKCKSVNTRLE 518
Query: 358 AVSSPSKKGSPL-ISRKSGRNTASKMKSPWSQLSSE---TLNQDTDKKIN-KNEIAKLEM 412
+ ++ L S +S + K+ ++E + + DKK N +N++ L+
Sbjct: 519 KTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD 578
Query: 413 VIQSLNK----DLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHV 468
++ L K + E V + DT +L Q + +
Sbjct: 579 QLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDT---AARLRKTQAESSKQIQQL 635
Query: 469 GTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLK----SAEEQITQLNDEIDAANK 524
+N D+ + + E K +L E +N++ +E + E I L I +
Sbjct: 636 ESNNRDLQDKNCLLETAKLKLEKEF--INLQSALESERRDRTHGSEIINDLQGRICGLEE 693
Query: 525 NMIKVK---SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL 581
++ K + +L+ +Q+Q+ + K SN EI +T +L + Q + + E E
Sbjct: 694 DLKNGKILLAKVELEKRQLQERFTDLEK-EKSNMEI-DMTYQLKVIQQSLEQEEAEHKAT 751
Query: 582 QLHLVD----YDSGRMIES----DVYKKMIE-------MENLAETRLKAISLLESQKFDL 626
+ L D Y+S +S ++ KK++E +ENL K SLL+
Sbjct: 752 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 811
Query: 627 VQELHILQQKYDEVEDKLADIS---QLQSDQVCSEIKSVHLE-EQIDALSASKKELALVI 682
Q+++ L ++ D + + + +++ + ++ + C + ++ +Q++ L S+K+L
Sbjct: 812 QQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQEN 871
Query: 683 ENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHE 742
+L K L +L +++D +++ +Q+ ++ + ++ EL K E
Sbjct: 872 NHLMEMKMNLEKQNAELRKERQDADGQMKE-LQDQLEAEQYFSTLYKTQVREL--KEECE 928
Query: 743 EQSKI--QTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
E++K+ + Q ERD +E L+K S +L SIA E++ LE++
Sbjct: 929 EKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE--QLARSIA--EEQYSDLEKEKI 984
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
++E + + ++D + A L + +R + + + +E +EL K L+
Sbjct: 985 MKELEIKEMMARHKQELTEKDATI---ASLEETNRTLTSDVANLANEKEELNNK----LK 1037
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAE-SESTKYQTQLRDLESNLKRITHEHQTLIV 919
+ Q L D + A+ + + L E + T+ +L ++ + + + + T +
Sbjct: 1038 DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1097
Query: 920 QKKKEIEDLEIEFNTQIE----SAIRDKKVLNE---KYEKNIEYVTQLEAQLQEYKNNIE 972
+K+KE L +E ++ E I+ +K LNE + + + +L+ L ++IE
Sbjct: 1098 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1157
Query: 973 NLNMNVEELN 982
L ++ L+
Sbjct: 1158 QLRSQLQALH 1167
Score = 74.5 bits (175), Expect = 3e-12
Identities = 123/633 (19%), Positives = 251/633 (39%), Gaps = 54/633 (8%)
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEIN-KLNALLKQKDEEII------- 1026
N +E+ K L +++H+ + Q+ + EQ +N +L K+ +EEI
Sbjct: 479 NEESQEIQK-KLYTLEEHLSNEM-QAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVES 536
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVR 1086
AL Q + + ++Y+ K K N+E ++ + QL D K+ N+ QI
Sbjct: 537 ALRQ-LEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTE 595
Query: 1087 EQDDQIKELKETKL---TFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLK 1143
+ + ++L ET T + S+ + ++NN D LK
Sbjct: 596 KVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK 655
Query: 1144 VQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKL 1203
+ E+EFI +S L+ + + E +N +L G +E + K L
Sbjct: 656 L--EKEFINLQSALESERRD----------RTHGSEIIN-DLQGRICGLEEDLKNGKILL 702
Query: 1204 EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHEL----RV 1259
++ E L +L S+ +++ + +Q L Q EA+ + T+ L ++
Sbjct: 703 AKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVI-QQSLEQEEAEHKATKARLADKNKI 761
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQ 1319
S E+K E + + + +E T K + + + + L+ Q+K +++ Q
Sbjct: 762 YESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQ 821
Query: 1320 IEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
++L ++ + DL+ + Q ++ S + +EN L +
Sbjct: 822 KDVLNEDVRN----LTLKIEQETQKRCLTQNDLKMQTQQVNTLK-MSEKQLKQENNHLME 876
Query: 1380 SSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQ 1439
DA+ ++ EL QLE +E Y T Y + + +E E +
Sbjct: 877 MKMNLEKQNAELRKERQDADGQMKELQDQLE---AEQYFSTL-YKTQVRELKEECEEKTK 932
Query: 1440 QLVEYEKRIEDLTYEKESELAILRLKM----HENANHYETMQKESEIERVKLIEELNVK- 1494
E +++ ++L E++S A L + + E ++ S++E+ K+++EL +K
Sbjct: 933 LGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKE 992
Query: 1495 --------ITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
+TE + + E N+ L +VA + L N+ ++ + + +
Sbjct: 993 MMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEIS 1052
Query: 1547 VRASSSKIQKHVSFASDTKQGRDEQLDNTMNKE 1579
A ++ +K + K +L MN++
Sbjct: 1053 AAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK 1085
Score = 64.5 bits (150), Expect = 3e-09
Identities = 137/697 (19%), Positives = 289/697 (41%), Gaps = 65/697 (9%)
Query: 847 ENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRT--DLAESESTK--YQTQLRD 902
E++E+QKK L E N + +++Q ++ + +T +L E + + ++ LR
Sbjct: 481 ESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQ 540
Query: 903 LESNLKRITH---EHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQ 959
LE + H E+Q + + +LE + N+ ++ + D K N+ + + E V Q
Sbjct: 541 LEREKALLQHKNAEYQRKADHEADKKRNLENDVNS-LKDQLEDLKKRNQNSQISTEKVNQ 599
Query: 960 LEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI----------N 1009
L+ QL E + + L K E K +Q+ ++ + D ++
Sbjct: 600 LQRQLDETNALLRTESDTAARLRKTQAES-SKQIQQLESNNRDLQDKNCLLETAKLKLEK 658
Query: 1010 EINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK---LAQFTTKLENMEEEMQR 1066
E L + L+ + + ++ IN+ Q + D ++ LA+ + ++E
Sbjct: 659 EFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTD 718
Query: 1067 VSKQLLDSK-QHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSD-D 1124
+ K+ + + +L+++ + + + E K TK + K I + E M + +
Sbjct: 719 LEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLA-DKNKIYESIEEAKSEAMKEME 777
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFI--------QERSVLQEQSAKLNTELQECYTKII 1176
++ L+ ++ + Q+ + L +Q LN +++ KI
Sbjct: 778 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIE 837
Query: 1177 QLETLNTELTGHDVVNQ-EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQR---G 1232
Q ET LT +D+ Q +Q+N LK +QL EN++L+ L + +R
Sbjct: 838 Q-ETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDAD 896
Query: 1233 FEIAELWKQHLAQRE-ADFQKTE-HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTME 1290
++ EL Q A++ + KT+ EL+ + ++K + L + Q+E + +
Sbjct: 897 GQMKELQDQLEAEQYFSTLYKTQVRELKEECEE-KTKLGKELQQKKQELQDERDSLAAQL 955
Query: 1291 QVTSLQNKLQDKEEHLRNL-QEKYAD-----VINQIEI----LRSEIE-DEKVAFXXXXX 1339
++T + D E+ R++ +E+Y+D ++ ++EI R + E EK A
Sbjct: 956 EITLTK---ADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE 1012
Query: 1340 XXXXXXXXXXXDLRTE----NQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRV 1395
+L E N K +QEQ + + +E
Sbjct: 1013 ETNRTLTSDVANLANEKEELNNKLKDVQEQ-LSRLKDEEISAAAIKAQFEKQLLTERTLK 1071
Query: 1396 NDAEAKVLELTHQLEL----KDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
A K+ E+ ++ E D+++ +K E + E E + QQ+++Y+K + ++
Sbjct: 1072 TQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEM 1131
Query: 1452 TYEKESELAI-LRLKMHENANHYETMQKESEIERVKL 1487
+ E I + L+M ++ + Q S+++ + +
Sbjct: 1132 QAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHI 1168
Score = 48.4 bits (110), Expect = 2e-04
Identities = 107/523 (20%), Positives = 215/523 (41%), Gaps = 44/523 (8%)
Query: 220 KMQENFI----AMEAEWKDEKQ--RLLKDIESKDVRISSLEEANKLLEAARFEISLEHSK 273
K+++ FI A+E+E +D ++ D++ RI LEE K + ++ LE +
Sbjct: 655 KLEKEFINLQSALESERRDRTHGSEIINDLQG---RICGLEEDLKNGKILLAKVELEKRQ 711
Query: 274 LAQ---ELEQXXXXXXXXXXXXXXLAKQSIEPSCEE----KTEIEEKG----SLEIAN-- 320
L + +LE+ + +QS+E E K + +K S+E A
Sbjct: 712 LQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSE 771
Query: 321 -MTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNT- 378
M E+ KK+ L ++ E E + + + + K +K + L+ +K N
Sbjct: 772 AMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLK---QSQQKINELLKQKDVLNED 828
Query: 379 ASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSL---NKDLVDKEYVISEKDTXX 435
+ Q + + D K+ ++ L+M + L N L++ + + +++
Sbjct: 829 VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAEL 888
Query: 436 XXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDE 492
G+ + Q QLE +Q+ V E+ E K+ ++L KQEL DE
Sbjct: 889 RKERQDADGQMKEL-QDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDE 947
Query: 493 IKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSD 552
+ + I K+ EQ+ + + ++ K K +L++K+M + ++++
Sbjct: 948 RDSLAAQLEITLTKADSEQLAR--SIAEEQYSDLEKEKIMKELEIKEMMAR--HKQELTE 1003
Query: 553 SNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS--GRMIESDVYKKMIEMENLAE 610
+ I L E L+ VA L EK L L D R+ + ++ I+ + E
Sbjct: 1004 KDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQ--FE 1061
Query: 611 TRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVH--LEEQI 668
+L L++Q + + E+ ++ D + ++ ++ E+KS L +Q+
Sbjct: 1062 KQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQM 1121
Query: 669 DALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
E+ I + +L T+ ++D E + ++LQ
Sbjct: 1122 IKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQ 1164
Score = 35.5 bits (78), Expect = 1.6
Identities = 53/261 (20%), Positives = 107/261 (40%), Gaps = 15/261 (5%)
Query: 160 VLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXXXXXXXEDTKQQMT 219
V ++K + E T L +++ +K Q ++ + + ++Q +
Sbjct: 920 VRELKEECEEKT--KLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYS 977
Query: 220 KMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELE 279
+++ I E E K+ R +++ KD I+SLEE N+ L + ++ E +L +L+
Sbjct: 978 DLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLK 1037
Query: 280 QXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIAN-MTELTKKIELLEHLN-CQ 337
A +I+ E++ E + N + E+ + E ++ N
Sbjct: 1038 DVQEQLSRLKDEEISAA--AIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTD 1095
Query: 338 IRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQD 397
+R+ KE EN+ M +S+ K +I + N + SQ+ E L
Sbjct: 1096 VRR--KEKENRKLHMELKSER----EKLTQQMIKYQKELNEMQAQIAEESQIRIE-LQMT 1148
Query: 398 TDKKINKNEIAKLEMVIQSLN 418
D K ++I +L +Q+L+
Sbjct: 1149 LDSK--DSDIEQLRSQLQALH 1167
Score = 33.1 bits (72), Expect = 8.5
Identities = 71/359 (19%), Positives = 140/359 (38%), Gaps = 32/359 (8%)
Query: 143 DVTHLSNTIKEKDNALSVLQ--VKMKIMETTILDLQEKI--NEKDQIIEAKNKATTXXXX 198
DV +L+ I+++ + Q +KM+ + L + EK E + ++E K
Sbjct: 828 DVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAE 887
Query: 199 XXXXXXXXXXXXXE-----DTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSL 253
E + +Q + + + + E +EK +L K+++ K +
Sbjct: 888 LRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQ-- 945
Query: 254 EEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSI-EPSCEEKTEIEE 312
+E + L AA+ EI+L + Q + + I E K E+ E
Sbjct: 946 DERDSL--AAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTE 1003
Query: 313 K----GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTES-KAVSSPSKKGS 367
K SLE N T LT + L + ++ K+++ +L+ + E A + ++
Sbjct: 1004 KDATIASLEETNRT-LTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEK 1062
Query: 368 PLISRKSGRNTA-SKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQS---------- 416
L++ ++ + A +K+ ++ DTD + + E KL M ++S
Sbjct: 1063 QLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMI 1122
Query: 417 -LNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
K+L + + I+E+ KD+ I QL+ + Q G +G+ D
Sbjct: 1123 KYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGD 1181
>M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy chain
protein.
Length = 1337
Score = 83.4 bits (197), Expect = 6e-15
Identities = 105/506 (20%), Positives = 222/506 (43%), Gaps = 23/506 (4%)
Query: 593 MIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQS 652
M + + K+ E + AE RL + L+SQ + ++L + +Q E E A+ +L++
Sbjct: 848 MAKEEELVKVREKQLAAENRLTEMETLQSQL--MAEKLQLQEQLQAETE-LCAEAEELRA 904
Query: 653 DQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQN 712
K LEE L A +E ++L+ +K+++ I++LE E+ + Q
Sbjct: 905 RLTA---KKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 713 YIQENMDLTDKLEKMSAEKI--SELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESE 770
E + KL+K+ E+I + K+ E++ + E + +++
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
+K+++ I LEE + E +R LE+ +L + +E Q EL +LA
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-- 1079
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
+ ++ L +E +E +KN + L++ + L+ +S++Q+ + E+A+R + AE
Sbjct: 1080 -KKEEELQAALARVE---EEAAQKN-MALKKIRELESQISELQEDLES--ERASR-NKAE 1131
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKY 950
+ +L L++ L+ + K +++ I T E A + + E
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMR 1191
Query: 951 EKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK-HVQKQQTQSPDYTEQYIN 1009
+K+ + V +L QL++ K NL + L EL ++ V Q ++ + +
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 1010 -EINKLNALLKQKDEEIIALNQKINNAQV---SYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
++ +L + + L K+ QV + ++S +SK ++ T +E ++Q
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 1066 RVSKQLLDSKQHNEELQILVREQDDQ 1091
+ L + + L +++ +D+
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDE 1337
Score = 62.5 bits (145), Expect = 1e-08
Identities = 107/533 (20%), Positives = 221/533 (41%), Gaps = 39/533 (7%)
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
K K + + QE+E++ + L+ +V EKQL E+ E++ L+ E LQ
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELV---KVREKQLAA-ENRLTEMETLQSQLMAEKLQLQ-- 886
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDL 928
+Q E ++ + + DLE+ ++ Q L +KKK +++
Sbjct: 887 -EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 929 -EIEFNTQIESAIRDK----KVLNE-KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELN 982
E+E + E + R K KV E K +K E LE Q + + L + E
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 983 KMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSM 1042
E +K K + + E I ++ + +++ +E+ +K+
Sbjct: 1006 TNLTEEEEK--SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063
Query: 1043 VSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTF 1102
+++ ++++A+ +L EEE+Q ++ + +RE + QI EL+E +
Sbjct: 1064 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE 1123
Query: 1103 EMNIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQ 1160
+ K E + +E + + + L+ + E+E + L+E+
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELED----TLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 1161 SAKLNTELQECYTKIIQ-LETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE 1219
+ ++QE K Q +E L +L EQ ++K+ LE+ +N E
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQL--------EQTKRVKANLEKAKQTLEN---ERGE 1228
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHE-LRVQLSAFESKYEQLLDSVQS- 1277
L + + + +G + K +E + E E +R +L+ +K + LD+V
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 1278 STQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDE 1330
+Q ++ + ++L+++LQD +E L+ + + +++ ++EDE
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK----QVEDE 1337
Score = 62.5 bits (145), Expect = 1e-08
Identities = 81/384 (21%), Positives = 171/384 (44%), Gaps = 45/384 (11%)
Query: 1145 QEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLE 1204
QEEE +E +++ + +L E ++ ++ETL ++L + QEQ+
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAE-----NRLTEMETLQSQLMAEKLQLQEQL-------- 889
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
Q TE L + ELR+ +++ E+ E+ A+ E + ++ +H L A
Sbjct: 890 QAETE---LCAEAEELRARLTAKKQ----ELEEICHDLEARVEEEEERCQH-----LQAE 937
Query: 1265 ESKYEQLLDSVQSSTQEETN--KIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEI 1322
+ K +Q + ++ +EE + + + +E+VT+ + KL+ EE L+++ + + ++
Sbjct: 938 KKKMQQNIQELEEQLEEEESARQKLQLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKL 996
Query: 1323 LRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSX 1382
L ++++A L+ ++++ E+ + ++ +L+K+
Sbjct: 997 L-----EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 1383 XXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLV 1442
++ + +A++ EL QL K+ E+ Q+N + +R
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR---- 1107
Query: 1443 EYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLN 1502
E E +I +L + ESE R ++ + +E E + +L + L+ + +
Sbjct: 1108 ELESQISELQEDLESE----RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 1503 KQVAELN---KALEEEVAKTNEMQ 1523
K+ E+N K LEEE AKT+E Q
Sbjct: 1164 KREQEVNILKKTLEEE-AKTHEAQ 1186
Score = 58.8 bits (136), Expect = 1e-07
Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 27/482 (5%)
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
RLTE SQ +AE + + LQ + + + K E+E + +
Sbjct: 867 RLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLAD----ISQLQSDQVCSEIKSVHLEEQIDALSAS 674
E + L E +QQ E+E++L + +LQ ++V +E K LEE+ L
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986
Query: 675 KKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENM-DLTDKL--EKMSAEK 731
+LA + L D+ + T E +K + KL+N + + DL ++L E+ ++
Sbjct: 987 NCKLAKE-KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIA---VM 788
+ + K+ + + A+I E + + E EL ++ + R+EE A +
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL---QAALARVEEEAAQKNMA 1102
Query: 789 EDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRL-AVLMDHDRVVEKQLLEIEHE 847
+ LE + +L L+ ++ + ++ Q+ +L L A+ + + ++ + E
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162
Query: 848 NKELQKKN---QILLEENQNLQISLSDM-QQHYNALVEKANRTDLAESESTKYQTQLRDL 903
+K Q+ N + L EE + + + +M Q+H A+ E A + + + + + L
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 904 ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNI-EYVTQLEA 962
E+ + +E + L+ Q K + E + Q++ ++ K E+ + + VT+L+
Sbjct: 1223 ENERGELANEVKVLL-QGKGDSEHKRKKVEAQLQE-LQVKFNEGERVRTELADKVTKLQV 1280
Query: 963 QLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKD 1022
+L + + +L K + ++ +Q Q + Q ++ L+ LKQ +
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTK-DFSALESQLQDTQELLQEENRQKLS----LSTKLKQVE 1335
Query: 1023 EE 1024
+E
Sbjct: 1336 DE 1337
Score = 58.8 bits (136), Expect = 1e-07
Identities = 93/491 (18%), Positives = 213/491 (43%), Gaps = 43/491 (8%)
Query: 228 MEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXX 287
++++ EK +L + ++++ + EE L A + E+ L +E+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 288 XXXXXXXLAK--QSIEPSCEEKTEIEEKGSLEIANMTELTKKIE----LLEHLNCQIRQT 341
+ + Q +E EE+ +K LE KK+E +LE NC++ +
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 342 NKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKK 401
K LE+++A T SK + +K+K+ E + D +++
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSK-------------SLAKLKN-----KHEAMITDLEER 1035
Query: 402 INKNEIAK--LEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQH 459
+ + E + LE + L D D I+E K+ + Q L +
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL-QAALARVEE 1094
Query: 460 MEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDE 518
+ + E ++I+++QE L+ E K + +DL E+L++ + T+L D
Sbjct: 1095 EAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK---TELEDT 1151
Query: 519 IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRL--TEELHHLSQKVAELEE 576
+D+ +++S + ++ ++KT++ +K ++ + +R ++ + L++++ + +
Sbjct: 1152 LDSTAAQQ-ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 577 EKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQK 636
K NL+ ++ R ++ K +++ + +E + K + E+Q +L + + ++
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV---EAQLQELQVKFNEGERV 1267
Query: 637 YDEVEDKLADISQLQSDQVC-----SEIKSVHLEEQIDALSASKKELALVIENLKLDKEQ 691
E+ DK+ + Q++ D V S+ KS L + AL + ++ +++ K
Sbjct: 1268 RTELADKVTKL-QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 692 LYGTIKDLEND 702
L +K +E++
Sbjct: 1327 LSTKLKQVEDE 1337
Score = 48.8 bits (111), Expect = 2e-04
Identities = 86/456 (18%), Positives = 196/456 (42%), Gaps = 33/456 (7%)
Query: 215 KQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKL 274
KQ++ ++ + A E ++ Q L + + I LEE + E+AR ++ LE
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 275 AQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHL 334
+L++ LAK EK +E++ + N+TE +K + L L
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAK--------EKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 335 NCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETL 394
+ +LE +L + + + +K G +T + Q L
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRK-------LEGDSTDLSDQIAELQAQIAEL 1074
Query: 395 NQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQL 454
KK + + A + ++ K++ K+ I E ++ + ++ +
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKK--IRELESQISELQEDLESERA--SRNKA 1130
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQ 514
E Q+ G L + T ED + Q++L+ + E+ ++ K L E+ K+ E QI +
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV-NILKKTLEEEAKTHEAQIQE 1189
Query: 515 LNDEIDAANKNM---IKVKSNHKLKLKQMQKTIDN-FSKVSDSNKEIVRLTEELHHLSQK 570
+ + A + + ++ K L++ ++T++N ++++ K +++ + H +K
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 571 V-AELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
V A+L+E LQ V ++ G + +++ K+ +++ + +S +S+ L ++
Sbjct: 1250 VEAQLQE----LQ---VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLE 665
L+ + + ++ L + ++ Q + +++K V E
Sbjct: 1303 FSALESQLQDTQELLQEENR-QKLSLSTKLKQVEDE 1337
Score = 46.0 bits (104), Expect = 0.001
Identities = 64/299 (21%), Positives = 123/299 (41%), Gaps = 23/299 (7%)
Query: 148 SNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKD---QIIEAKNKATTXXXXXXXXXX 204
+N +E++ + S+ ++K K E I DL+E++ ++ Q +E +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNK-HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 205 XXXXXXXEDTKQQMTKMQENFIAMEAEWKDE---KQRLLKDIESKDVRISSLEEANKLLE 261
+ K Q+ K +E A A ++E K LK I + +IS L+E +
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 262 AARFEISLEHSKLAQELE----QXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLE 317
A+R + + L +ELE + +K+ E + +KT +EE+
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT-LEEEAKTH 1183
Query: 318 IANMTELTKK-IELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGR 376
A + E+ +K + +E L Q+ QT + N T + + L+ K
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG-- 1241
Query: 377 NTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMV--IQSLNKDLVDKEYVISEKDT 433
++ K K +QL Q+ K N+ E + E+ + L +L + ++S+ D+
Sbjct: 1242 DSEHKRKKVEAQL------QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294
>M63618-1|AAA35606.1| 2095|Homo sapiens bullous pemphigoid antigen
protein.
Length = 2095
Score = 83.0 bits (196), Expect = 8e-15
Identities = 152/793 (19%), Positives = 337/793 (42%), Gaps = 72/793 (9%)
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
+LT ++ L + VAEL+++K ++ L E+++ K+ +E+++ +++A
Sbjct: 581 KLTGKISELERMVAELKKQKSRVEEELPKVREA--AENELRKQQRNVEDISLQKIRA--- 635
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
ES+ +EL + ++ + E +L + QL + +E K +EE + +E
Sbjct: 636 -ESEAKQYRRELETIVREKEAAERELERVRQLTIE---AEAKRAAVEENLLNFRNQLEEN 691
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL-LA 737
L+ ++ ++ DLE K NKL ++ D ++L K+ + +L
Sbjct: 692 TFTRRTLEDHLKRKDLSLNDLEQQK----NKLMEELRRKRDNEEELLKLIKQMEKDLAFQ 747
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K E+Q K + + ++A+ + ++ E+ L +C + ++ + L++
Sbjct: 748 KQVAEKQLKEKQKIELEARRKITEIQYTCRENALP-----VCPITQATSCRAVT--GLQQ 800
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
+ D KQKA +EL ++ L +R E+ + E+ +E LQ +
Sbjct: 801 EHD--------KQKA--------EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS 844
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
E+ + L+ L + L + R D AE Y QLR+L L + T + +
Sbjct: 845 SEEKARLLKDKLDETNNTLRCLKLELERKDQAEK---GYSQQLRELGRQLNQTTGKAEE- 900
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
+Q+ +++ ++ + ++ES +K L + ++ E +Q + I + +
Sbjct: 901 AMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR-D 959
Query: 978 VEELNKMNL-ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+EL ++ + + H+++Q +S + Q I + N +++ +EE+ N+ +
Sbjct: 960 EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLK 1019
Query: 1037 VSYMSMV-SDYESKL--AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + E+KL + + EN+ E Q + ++ K + + +R ++ +
Sbjct: 1020 QKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLH 1079
Query: 1094 ELKETKLTFEMNIPKTE-----GMIISSTIEPMSDDAN-NVDXXXXXXXXXXXXLKVQEE 1147
+ +T+ F+ I E + S + D N + L +E
Sbjct: 1080 KQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKE 1139
Query: 1148 EEFIQERSV--LQEQSAKLNTELQECYTKIIQLETLNTELTGHD-VVNQEQINQLKSKLE 1204
E+ E+ V Q Q +LN L++ + + L+T+ ++T V+ QE+ + K E
Sbjct: 1140 EKRRGEQKVQLQQAQVQELNNRLKKVQDE-LHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1198
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
+ + + L + S + + D G + + L Q + Q+ +
Sbjct: 1199 EFRKKMEKL------MESKVITENDISGIRLDFV---SLQQENSRAQENAKLCETNIKEL 1249
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVI----NQI 1320
E + +Q + +Q E N ++ L+++L ++ + NL++K I +Q+
Sbjct: 1250 ERQLQQYREQMQQGQHMEANH---YQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1306
Query: 1321 EILRSEIEDEKVA 1333
+L+ EI+ + A
Sbjct: 1307 VLLQCEIQKKSTA 1319
Score = 65.3 bits (152), Expect = 2e-09
Identities = 133/676 (19%), Positives = 282/676 (41%), Gaps = 60/676 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEK--QRLLKD-IESKDVRISSLEEA-NKLLEAARFEIS 268
+ + + ++EN + + ++ +R L+D ++ KD+ ++ LE+ NKL+E R +
Sbjct: 669 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 728
Query: 269 LEHS--KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK-TEIE---EKGSLEIANMT 322
E KL +++E+ KQ IE K TEI+ + +L + +T
Sbjct: 729 NEEELLKLIKQMEKDLAFQKQVAEKQLK-EKQKIELEARRKITEIQYTCRENALPVCPIT 787
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+ T + +Q +EL+ ++ + ++ ++K + + A ++
Sbjct: 788 QATSCRAVTGLQQEHDKQKAEELKQQVDEL-------TAANRKAEQDMRELTYELNALQL 840
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ S+ + L D+ N KLE+ KD +K Y ++
Sbjct: 841 EKTSSEEKARLLKDKLDETNNTLRCLKLELE----RKDQAEKGYSQQLRELGRQLNQTTG 896
Query: 443 XGKDTL--IAQLQ-LEHQQHMEGPSLIHV-GTNTEDVNEIAK---VQEQLKQELNDEIKD 495
++ + + L+ ++ +E SL H G +V+ I + V E+ Q LN +I
Sbjct: 897 KAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHS 956
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+ +E+L+ + + L ++ + +H+ L+ ++ +N K+ N+
Sbjct: 957 FRDEKELERLQICQRKSDHLKEQFE----------KSHEQLLQNIKAEKENNDKIQRLNE 1006
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ + E L QKV EL + +L + + E+ V +K + +++A
Sbjct: 1007 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES--ENIVLEKQTIQQRCEALKIQA 1064
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQ--LQSDQVCSEIKSVHLEEQIDALSA 673
+ Q + LH + + + K+ + + +S + SE K ++Q +
Sbjct: 1065 DG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ-KCDQQNIIIQN 1122
Query: 674 SKKELALVIENLKLDKEQ-LYGTIK-DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
+KKE+ + L KE+ G K L+ + +N +Q+ + L E+M+ K
Sbjct: 1123 TKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRK 1182
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN----IESELSKYKSRICRLEESIAV 787
+ + +QS + + ++ K+ E + EN I + + R +E+ +
Sbjct: 1183 MVLFQEESGKFKQSAEEFRKKME-KLMESKVITENDISGIRLDFVSLQQENSRAQENAKL 1241
Query: 788 MEDRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
E LER+ Q +Q+ Q Y + EDEL+ + + + + +++Q+ E
Sbjct: 1242 CETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKE 1301
Query: 844 IEHE----NKELQKKN 855
EH+ E+QKK+
Sbjct: 1302 HEHQLVLLQCEIQKKS 1317
Score = 59.3 bits (137), Expect = 1e-07
Identities = 147/860 (17%), Positives = 351/860 (40%), Gaps = 68/860 (7%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
IEN+ S L +++S + + +ED + +D++ +E+ + + + D+L
Sbjct: 328 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 387
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL------LEENQNLQISLSDMQ-QHY 876
V R + H + ++ +L ++E K L+ +++ + Q + + Q ++
Sbjct: 388 VERWQNV--HVQ-IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 444
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRIT-----HEHQTLIVQKKKEIEDLEIE 931
L + N+ + SE Q+++ + + ++ + +E QT+ + + +
Sbjct: 445 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 504
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
+++S+ ++ E + Y + Q K ++L EE K E +
Sbjct: 505 KRRRMQSSA--DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 562
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
Q T + E +KL + + + + L ++ + + + E++L
Sbjct: 563 GAYSDLLQRQKAT---VLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 619
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETK-LTFEMNIPKTE 1110
+ +E++ +Q++ + ++KQ+ EL+ +VRE++ +EL+ + LT E +
Sbjct: 620 KQQRNVEDI--SLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKR-- 674
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE--EEEFIQERSVLQEQSAKLNTEL 1168
++ E + + N ++ LK ++ + Q+++ L E+ +
Sbjct: 675 ----AAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE 730
Query: 1169 QECYTKIIQLE---TLNTELTGHDVVNQEQIN-QLKSKLEQLN-TENDNLLS----TVAE 1219
+E I Q+E ++ + +++I + + K+ ++ T +N L T A
Sbjct: 731 EELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQAT 790
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR---VQLSAFESKYEQLLDSVQ 1276
+++ + + AE KQ + + A +K E ++R +L+A + + + +
Sbjct: 791 SCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKAR 850
Query: 1277 --SSTQEETNKIVTMEQVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ETN + ++ L+ K Q ++ + LR L + + E E D K
Sbjct: 851 LLKDKLDETNNTLRCLKL-ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK 909
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
L+ E + + NI N+Q+
Sbjct: 910 -KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQI 968
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
R +D + E +H+ L++ + ++ ++ + + N+E E + ++++E+L
Sbjct: 969 CQRKSDHLKEQFEKSHEQLLQNIKAEKENND---KIQRLNEELEKSNECAEMLKQKVEEL 1025
Query: 1452 TYE-KESELAILRLKMH-EN-ANHYETMQKESEIERVKL------IEELNVKITESVSLN 1502
T + E++L + R++ EN +T+Q+ E +++ + N + +
Sbjct: 1026 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTE 1085
Query: 1503 KQVAELNKALEEEVAKT----NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
+ K LEE++AK+ +E + + Q I I E+ NL + AS + ++
Sbjct: 1086 QDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEE-KRRG 1144
Query: 1559 SFASDTKQGRDEQLDNTMNK 1578
+Q + ++L+N + K
Sbjct: 1145 EQKVQLQQAQVQELNNRLKK 1164
>L11690-1|AAA52288.1| 2649|Homo sapiens bullous pemphigoid antigen
protein.
Length = 2649
Score = 83.0 bits (196), Expect = 8e-15
Identities = 152/793 (19%), Positives = 337/793 (42%), Gaps = 72/793 (9%)
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
+LT ++ L + VAEL+++K ++ L E+++ K+ +E+++ +++A
Sbjct: 1135 KLTGKISELERMVAELKKQKSRVEEELPKVREA--AENELRKQQRNVEDISLQKIRA--- 1189
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
ES+ +EL + ++ + E +L + QL + +E K +EE + +E
Sbjct: 1190 -ESEAKQYRRELETIVREKEAAERELERVRQLTIE---AEAKRAAVEENLLNFRNQLEEN 1245
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL-LA 737
L+ ++ ++ DLE K NKL ++ D ++L K+ + +L
Sbjct: 1246 TFTRRTLEDHLKRKDLSLNDLEQQK----NKLMEELRRKRDNEEELLKLIKQMEKDLAFQ 1301
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K E+Q K + + ++A+ + ++ E+ L +C + ++ + L++
Sbjct: 1302 KQVAEKQLKEKQKIELEARRKITEIQYTCRENALP-----VCPITQATSCRAVT--GLQQ 1354
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
+ D KQKA +EL ++ L +R E+ + E+ +E LQ +
Sbjct: 1355 EHD--------KQKA--------EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS 1398
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
E+ + L+ L + L + R D AE Y QLR+L L + T + +
Sbjct: 1399 SEEKARLLKDKLDETNNTLRCLKLELERKDQAEK---GYSQQLRELGRQLNQTTGKAEE- 1454
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
+Q+ +++ ++ + ++ES +K L + ++ E +Q + I + +
Sbjct: 1455 AMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR-D 1513
Query: 978 VEELNKMNL-ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+EL ++ + + H+++Q +S + Q I + N +++ +EE+ N+ +
Sbjct: 1514 EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLK 1573
Query: 1037 VSYMSMV-SDYESKL--AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + E+KL + + EN+ E Q + ++ K + + +R ++ +
Sbjct: 1574 QKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLH 1633
Query: 1094 ELKETKLTFEMNIPKTE-----GMIISSTIEPMSDDAN-NVDXXXXXXXXXXXXLKVQEE 1147
+ +T+ F+ I E + S + D N + L +E
Sbjct: 1634 KQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKE 1693
Query: 1148 EEFIQERSV--LQEQSAKLNTELQECYTKIIQLETLNTELTGHD-VVNQEQINQLKSKLE 1204
E+ E+ V Q Q +LN L++ + + L+T+ ++T V+ QE+ + K E
Sbjct: 1694 EKRRGEQKVQLQQAQVQELNNRLKKVQDE-LHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1752
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
+ + + L + S + + D G + + L Q + Q+ +
Sbjct: 1753 EFRKKMEKL------MESKVITENDISGIRLDFV---SLQQENSRAQENAKLCETNIKEL 1803
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVI----NQI 1320
E + +Q + +Q E N ++ L+++L ++ + NL++K I +Q+
Sbjct: 1804 ERQLQQYREQMQQGQHMEANH---YQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
Query: 1321 EILRSEIEDEKVA 1333
+L+ EI+ + A
Sbjct: 1861 VLLQCEIQKKSTA 1873
Score = 65.3 bits (152), Expect = 2e-09
Identities = 133/676 (19%), Positives = 282/676 (41%), Gaps = 60/676 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEK--QRLLKD-IESKDVRISSLEEA-NKLLEAARFEIS 268
+ + + ++EN + + ++ +R L+D ++ KD+ ++ LE+ NKL+E R +
Sbjct: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
Query: 269 LEHS--KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK-TEIE---EKGSLEIANMT 322
E KL +++E+ KQ IE K TEI+ + +L + +T
Sbjct: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLK-EKQKIELEARRKITEIQYTCRENALPVCPIT 1341
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+ T + +Q +EL+ ++ + ++ ++K + + A ++
Sbjct: 1342 QATSCRAVTGLQQEHDKQKAEELKQQVDEL-------TAANRKAEQDMRELTYELNALQL 1394
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ S+ + L D+ N KLE+ KD +K Y ++
Sbjct: 1395 EKTSSEEKARLLKDKLDETNNTLRCLKLELE----RKDQAEKGYSQQLRELGRQLNQTTG 1450
Query: 443 XGKDTL--IAQLQ-LEHQQHMEGPSLIHV-GTNTEDVNEIAK---VQEQLKQELNDEIKD 495
++ + + L+ ++ +E SL H G +V+ I + V E+ Q LN +I
Sbjct: 1451 KAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHS 1510
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+ +E+L+ + + L ++ + +H+ L+ ++ +N K+ N+
Sbjct: 1511 FRDEKELERLQICQRKSDHLKEQFE----------KSHEQLLQNIKAEKENNDKIQRLNE 1560
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ + E L QKV EL + +L + + E+ V +K + +++A
Sbjct: 1561 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES--ENIVLEKQTIQQRCEALKIQA 1618
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQ--LQSDQVCSEIKSVHLEEQIDALSA 673
+ Q + LH + + + K+ + + +S + SE K ++Q +
Sbjct: 1619 DG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ-KCDQQNIIIQN 1676
Query: 674 SKKELALVIENLKLDKEQ-LYGTIK-DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
+KKE+ + L KE+ G K L+ + +N +Q+ + L E+M+ K
Sbjct: 1677 TKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRK 1736
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN----IESELSKYKSRICRLEESIAV 787
+ + +QS + + ++ K+ E + EN I + + R +E+ +
Sbjct: 1737 MVLFQEESGKFKQSAEEFRKKME-KLMESKVITENDISGIRLDFVSLQQENSRAQENAKL 1795
Query: 788 MEDRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
E LER+ Q +Q+ Q Y + EDEL+ + + + + +++Q+ E
Sbjct: 1796 CETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKE 1855
Query: 844 IEHE----NKELQKKN 855
EH+ E+QKK+
Sbjct: 1856 HEHQLVLLQCEIQKKS 1871
Score = 59.3 bits (137), Expect = 1e-07
Identities = 147/860 (17%), Positives = 351/860 (40%), Gaps = 68/860 (7%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
IEN+ S L +++S + + +ED + +D++ +E+ + + + D+L
Sbjct: 882 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL------LEENQNLQISLSDMQ-QHY 876
V R + H + ++ +L ++E K L+ +++ + Q + + Q ++
Sbjct: 942 VERWQNV--HVQ-IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 998
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRIT-----HEHQTLIVQKKKEIEDLEIE 931
L + N+ + SE Q+++ + + ++ + +E QT+ + + +
Sbjct: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
+++S+ ++ E + Y + Q K ++L EE K E +
Sbjct: 1059 KRRRMQSSA--DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
Q T + E +KL + + + + L ++ + + + E++L
Sbjct: 1117 GAYSDLLQRQKAT---VLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETK-LTFEMNIPKTE 1110
+ +E++ +Q++ + ++KQ+ EL+ +VRE++ +EL+ + LT E +
Sbjct: 1174 KQQRNVEDI--SLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKR-- 1228
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE--EEEFIQERSVLQEQSAKLNTEL 1168
++ E + + N ++ LK ++ + Q+++ L E+ +
Sbjct: 1229 ----AAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE 1284
Query: 1169 QECYTKIIQLE---TLNTELTGHDVVNQEQIN-QLKSKLEQLN-TENDNLLS----TVAE 1219
+E I Q+E ++ + +++I + + K+ ++ T +N L T A
Sbjct: 1285 EELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQAT 1344
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR---VQLSAFESKYEQLLDSVQ 1276
+++ + + AE KQ + + A +K E ++R +L+A + + + +
Sbjct: 1345 SCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKAR 1404
Query: 1277 --SSTQEETNKIVTMEQVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ETN + ++ L+ K Q ++ + LR L + + E E D K
Sbjct: 1405 LLKDKLDETNNTLRCLKL-ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK 1463
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
L+ E + + NI N+Q+
Sbjct: 1464 -KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQI 1522
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
R +D + E +H+ L++ + ++ ++ + + N+E E + ++++E+L
Sbjct: 1523 CQRKSDHLKEQFEKSHEQLLQNIKAEKENND---KIQRLNEELEKSNECAEMLKQKVEEL 1579
Query: 1452 TYE-KESELAILRLKMH-EN-ANHYETMQKESEIERVKL------IEELNVKITESVSLN 1502
T + E++L + R++ EN +T+Q+ E +++ + N + +
Sbjct: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTE 1639
Query: 1503 KQVAELNKALEEEVAKT----NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
+ K LEE++AK+ +E + + Q I I E+ NL + AS + ++
Sbjct: 1640 QDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEE-KRRG 1698
Query: 1559 SFASDTKQGRDEQLDNTMNK 1578
+Q + ++L+N + K
Sbjct: 1699 EQKVQLQQAQVQELNNRLKK 1718
>BC108904-1|AAI08905.1| 725|Homo sapiens hyaluronan-mediated motility
receptor (RHAMM) protein.
Length = 725
Score = 83.0 bits (196), Expect = 8e-15
Identities = 149/689 (21%), Positives = 294/689 (42%), Gaps = 73/689 (10%)
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYE--KNIEYVTQLEAQ----LQEYKNNIEN 973
Q+K+ ++L ++ +T + ++ R K K E KN + + LE + LQE
Sbjct: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEICVLLQERGAQDRR 105
Query: 974 LNMNVEELNKMNLELIDKHVQKQQTQSPDYT-EQYINEINKLNALLKQKDEEIIALNQK- 1031
+ EL KM L +K + + T E+ + E+ + N LLK K E NQK
Sbjct: 106 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE--NGNQKN 163
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ-ILVREQDD 1090
+ + M + + E+K+ K E ME ++Q + L +S+ +L+ LV + +
Sbjct: 164 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 223
Query: 1091 QIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEF 1150
+I E ET+ E IE +S ++ V+ LK ++ +E
Sbjct: 224 KIDEKSETEKLLEY-------------IEEISCASDQVEKYKLDIAQLEENLK-EKNDEI 269
Query: 1151 IQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEN 1210
+ + L+E L+ Q+E LN + + ++ +N+ + E LN E
Sbjct: 270 LSLKQSLEENIVILSK----------QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEM 319
Query: 1211 DNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT---EHELRVQLSAFESK 1267
NL L + Q+ +I L +Q + QK + E+ + + FE +
Sbjct: 320 QNLKQKFI-LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMAKEKNLFEEE 378
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
+Q LD + Q+E ++Q L+ + + + E L+ L+EK + E+ +S
Sbjct: 379 LKQTLDELDKLQQKEEQAERLVKQ---LEEEAKSRAEELKLLEEKLKG--KEAELEKSSA 433
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXX 1387
+ D+ + +SYK + I ++ EN+ L++
Sbjct: 434 AHTQATLLLQEKYDSMVQSLE--DVTAQFESYKALTASEIEDLKLENSSLQEKVAKAGKN 491
Query: 1388 XXXXXXRVNDAEAK-------VLELTHQLELKDSEIYQKTHEYTITLTQRNDEFEN-VRQ 1439
++ E+ +L+L + LK++EI E T++ Q+ + +N ++Q
Sbjct: 492 AEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI----KEITVSFLQKITDLQNQLKQ 547
Query: 1440 QLVEYEKRIED---LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKIT 1496
Q ++ K++ED EKE+ A L ++++ YE + +++ +++L ++
Sbjct: 548 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA---FEVE 604
Query: 1497 ESVSLNKQVA---ELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
+ LN+ A +LNK + + AK Q L+ + +V L DE + L++ V SK
Sbjct: 605 KQALLNEHGAAQEQLNK-IRDSYAKLLGHQN-LKQKIKHVVKLKDENSQLKSEV----SK 658
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELLD 1582
++ ++ ++ E+L+ + + D
Sbjct: 659 LRCQLAKKKQSETKLQEELNKVLGIKHFD 687
Score = 77.0 bits (181), Expect = 5e-13
Identities = 97/512 (18%), Positives = 223/512 (43%), Gaps = 37/512 (7%)
Query: 807 QEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQ 866
+E QK + I E E+ VL+ ++++ ++E E ++++ + L E +L
Sbjct: 76 KESQKNDKDLKILEKEI----CVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLS 131
Query: 867 ISLSDMQQHYNALVEKANRTDLAESESTKY--QTQLRDLESNLKRITHEHQTLIVQKKKE 924
+ + +++ L+E +L +S+ ++ Q LR L L ++ ++ +T + +
Sbjct: 132 ANNATLEKQ---LIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 188
Query: 925 IEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKM 984
E +E++ S + + + K + +E + + K+ E L +EE++
Sbjct: 189 QEGMEMKLQVTQRSLEESQGKIAQLEGK----LVSIEKEKIDEKSETEKLLEYIEEIS-- 242
Query: 985 NLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVS 1044
V+K + E + +++ +L + +E I+ L++++ + V +
Sbjct: 243 ---CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
Query: 1045 DYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM 1104
+ E + + EN+ EMQ + ++ + +Q E+LQ + D +++ KE +
Sbjct: 300 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ 359
Query: 1105 NIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQ-EQSAK 1163
+ S E M+ + N + L+ +EE+ ER V Q E+ AK
Sbjct: 360 K--------LCSFQEEMAKEKNLFEEELKQTLDELDKLQQKEEQ---AERLVKQLEEEAK 408
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
E + + +L+ EL + + L+ K + + +++ + ++
Sbjct: 409 SRAEELKLLEE--KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKAL 466
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEET 1283
+S ++ E + L ++ +A+ + + +H++ S+ + LLD S +ET
Sbjct: 467 TASEIEDLKLENSSL-QEKVAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 525
Query: 1284 N-KIVT---MEQVTSLQNKLQDKEEHLRNLQE 1311
K +T ++++T LQN+L+ +EE R E
Sbjct: 526 EIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
Score = 75.4 bits (177), Expect = 2e-12
Identities = 119/594 (20%), Positives = 257/594 (43%), Gaps = 48/594 (8%)
Query: 504 KLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM-QKTIDNF---SKVSDSNKEIVR 559
+++ E ++ ++ ++AA + + +N+ KQ+ + T N SK S++ +
Sbjct: 105 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ--- 161
Query: 560 LTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMEN--LAETRLKAIS 617
+ L LS ++ +L ++ ++ G ++ V ++ +E +A+ K +S
Sbjct: 162 --KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 219
Query: 618 LLESQKFD-------LVQELHILQQKYDEVEDKLADISQLQSD--QVCSEIKSVH--LEE 666
+ E +K D L++ + + D+VE DI+QL+ + + EI S+ LEE
Sbjct: 220 I-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE 278
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDL-ENDKEDIMNKLQNYIQENMDLTDKLE 725
I LS ++L + + L+ +KE ++ EN ++ N Q +I E + +KL+
Sbjct: 279 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE-REKLQ 337
Query: 726 KMSAEKISELLAKINHEEQSKIQTQFGIDAKI-QERDLYIENIESELSKYKSRICRLEES 784
+ + I LL + S Q ++ +E++L+ E ++ L + + E++
Sbjct: 338 QKELQ-IDSLLQQEKELSSSLHQKLCSFQEEMAKEKNLFEEELKQTLDELDKLQQKEEQA 396
Query: 785 IAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEI 844
+++ + +A++L L+EK K E +++ + A L+ ++ + + +
Sbjct: 397 ERLVKQLEEEAKSRAEEL-KLLEEKLKG-KEAELEKSSAAHTQATLLLQEKY-DSMVQSL 453
Query: 845 EHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTD----LAESESTKYQTQL 900
E + + + E ++L++ S +Q+ + A ES + +Y L
Sbjct: 454 EDVTAQFESYKALTASEIEDLKLENSSLQEKVAKAGKNAEDVQHQILATESSNQEYVRML 513
Query: 901 RDL-------ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKN 953
DL E+ +K IT I + +++ E +F Q+E K +
Sbjct: 514 LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAEL 573
Query: 954 IEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINK 1013
E + + +E N + + ++ L+++H Q+ Q + Y +
Sbjct: 574 TEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QLNKIRDSYAKLLGH 632
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
N LKQK + ++ L K N+Q+ S VS +LA+ ++EE+ +V
Sbjct: 633 QN--LKQKIKHVVKL--KDENSQLK--SEVSKLRCQLAKKKQSETKLQEELNKV 680
Score = 51.6 bits (118), Expect = 2e-05
Identities = 136/697 (19%), Positives = 282/697 (40%), Gaps = 66/697 (9%)
Query: 230 AEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFEISLEHSKLAQELEQXXXXXXXXX 289
+E K E Q+ KD++ + I L + + ++ E K+ L
Sbjct: 72 SESKKESQKNDKDLKILEKEICVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLS 131
Query: 290 XXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKL 349
L KQ IE + E+ + E N L +I LE + + ++ K
Sbjct: 132 ANNATLEKQLIELT--RTNELLKSKFSENGNQKNL--RILSLELMKLRNKRETKMRGMMA 187
Query: 350 ATMGTESKA-VSSPSKKGSP-LISRKSGRNTASKMKSPWSQLSSETLNQDTDK-KINKNE 406
G E K V+ S + S I++ G+ + + + + +E L + ++ ++
Sbjct: 188 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 247
Query: 407 IAKLEMVIQSLNKDLVDK-EYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSL 465
+ K ++ I L ++L +K + ++S K + + L + QL ++ +
Sbjct: 248 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED---- 303
Query: 466 IHVGTNTEDVNEIAKVQEQLKQEL---NDEIKDVNVKDL-IEKLKSAEEQITQ-LNDEID 520
HV N E + + LKQ+ E + + K+L I+ L E++++ L+ ++
Sbjct: 304 -HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLC 362
Query: 521 AANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGN 580
+ + M K K+ + +LKQ D K+ ++ RL V +LEEE +
Sbjct: 363 SFQEEMAKEKNLFEEELKQTL---DELDKLQQKEEQAERL----------VKQLEEEAKS 409
Query: 581 LQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYD-- 638
L +++E + K E+E + +A LL+ + +VQ L + +++
Sbjct: 410 RAEEL------KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 463
Query: 639 ------EVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
E+ED + S LQ + + ++ QI A +S +E ++ +L Q
Sbjct: 464 KALTASEIEDLKLENSSLQEKVAKAGKNAEDVQHQILATESSNQEYVRMLLDL-----QT 518
Query: 693 YGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
+K+ E I +++Q+ DL ++L K E + L + K T
Sbjct: 519 KSALKETE-----IKEITVSFLQKITDLQNQL-KQQEEDFRKQLEDEEGRKAEKENTTAE 572
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLE-ESIAVMEDRRYSLERKADQLGSYLQEKQK 811
+ +I + L E + ++ ++ ++ E E A++ + + E QL K
Sbjct: 573 LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE----QLNKIRDSYAK 628
Query: 812 AYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHE-NKELQKKNQILLEENQNLQISLS 870
+++ + + L D + ++ ++ ++ + K+ Q + ++ E N+ L I
Sbjct: 629 LLGHQNLKQK--IKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 686
Query: 871 DMQQ--HYNALVEKANRTDLAESESTKYQTQLRDLES 905
D + H+ + A +T L E + Y+ + ES
Sbjct: 687 DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQES 723
Score = 44.4 bits (100), Expect = 0.003
Identities = 77/456 (16%), Positives = 186/456 (40%), Gaps = 21/456 (4%)
Query: 1142 LKVQEEE--EFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQL 1199
LK+ E+E +QER + L TEL++ ++ T L+ ++ ++Q+ +L
Sbjct: 85 LKILEKEICVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 144
Query: 1200 KSKLEQLNT---ENDNLLSTVAELRSSISSAVDQRGFEIAELW-KQHLAQREADF-QKTE 1254
E L + EN N + L + ++R ++ + KQ + + Q++
Sbjct: 145 TRTNELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 203
Query: 1255 HELRVQLSAFESKYEQLLDSVQSSTQEETNKIVT-MEQVTSLQNKLQDKEEHLRNLQEKY 1313
E + +++ E K + + + + ET K++ +E+++ ++++ + + L+E
Sbjct: 204 EESQGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 262
Query: 1314 ADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEE 1373
+ ++I L+ +E+ V L E + + + N+N E
Sbjct: 263 KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL----LEKEKEDHVNRNREHNENLNAE 318
Query: 1374 NAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDE 1433
LK+ ++ E ++ L Q + S ++QK + + + +
Sbjct: 319 MQNLKQK----FILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMAKEKNL 374
Query: 1434 FENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNV 1493
FE +Q ++ +++ + E + L + A + ++++ + + +L +
Sbjct: 375 FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 434
Query: 1494 KITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
++ L ++ + ++LE+ A+ E AL EIE + L E ++LQ V +
Sbjct: 435 HTQATLLLQEKYDSMVQSLEDVTAQF-ESYKALTASEIEDLKL--ENSSLQEKVAKAGKN 491
Query: 1554 IQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAEL 1589
+ T+ E + ++ + A+ E+
Sbjct: 492 AEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 527
>AL096710-6|CAI22047.1| 2649|Homo sapiens dystonin protein.
Length = 2649
Score = 83.0 bits (196), Expect = 8e-15
Identities = 152/793 (19%), Positives = 337/793 (42%), Gaps = 72/793 (9%)
Query: 559 RLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL 618
+LT ++ L + VAEL+++K ++ L E+++ K+ +E+++ +++A
Sbjct: 1135 KLTGKISELERMVAELKKQKSRVEEELPKVREA--AENELRKQQRNVEDISLQKIRA--- 1189
Query: 619 LESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKEL 678
ES+ +EL + ++ + E +L + QL + +E K +EE + +E
Sbjct: 1190 -ESEAKQYRRELETIVREKEAAERELERVRQLTIE---AEAKRAAVEENLLNFRNQLEEN 1245
Query: 679 ALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL-LA 737
L+ ++ ++ DLE K NKL ++ D ++L K+ + +L
Sbjct: 1246 TFTRRTLEDHLKRKDLSLNDLEQQK----NKLMEELRRKRDNEEELLKLIKQMEKDLAFQ 1301
Query: 738 KINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLER 797
K E+Q K + + ++A+ + ++ E+ L +C + ++ + L++
Sbjct: 1302 KQVAEKQLKEKQKIELEARRKITEIQYTCRENALP-----VCPITQATSCRAVT--GLQQ 1354
Query: 798 KADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQI 857
+ D KQKA +EL ++ L +R E+ + E+ +E LQ +
Sbjct: 1355 EHD--------KQKA--------EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS 1398
Query: 858 LLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL 917
E+ + L+ L + L + R D AE Y QLR+L L + T + +
Sbjct: 1399 SEEKARLLKDKLDETNNTLRCLKLELERKDQAEK---GYSQQLRELGRQLNQTTGKAEE- 1454
Query: 918 IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMN 977
+Q+ +++ ++ + ++ES +K L + ++ E +Q + I + +
Sbjct: 1455 AMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR-D 1513
Query: 978 VEELNKMNL-ELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
+EL ++ + + H+++Q +S + Q I + N +++ +EE+ N+ +
Sbjct: 1514 EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLK 1573
Query: 1037 VSYMSMV-SDYESKL--AQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK 1093
+ + E+KL + + EN+ E Q + ++ K + + +R ++ +
Sbjct: 1574 QKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLH 1633
Query: 1094 ELKETKLTFEMNIPKTE-----GMIISSTIEPMSDDAN-NVDXXXXXXXXXXXXLKVQEE 1147
+ +T+ F+ I E + S + D N + L +E
Sbjct: 1634 KQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKE 1693
Query: 1148 EEFIQERSV--LQEQSAKLNTELQECYTKIIQLETLNTELTGHD-VVNQEQINQLKSKLE 1204
E+ E+ V Q Q +LN L++ + + L+T+ ++T V+ QE+ + K E
Sbjct: 1694 EKRRGEQKVQLQQAQVQELNNRLKKVQDE-LHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1752
Query: 1205 QLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAF 1264
+ + + L + S + + D G + + L Q + Q+ +
Sbjct: 1753 EFRKKMEKL------MESKVITENDISGIRLDFV---SLQQENSRAQENAKLCETNIKEL 1803
Query: 1265 ESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVI----NQI 1320
E + +Q + +Q E N ++ L+++L ++ + NL++K I +Q+
Sbjct: 1804 ERQLQQYREQMQQGQHMEANH---YQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
Query: 1321 EILRSEIEDEKVA 1333
+L+ EI+ + A
Sbjct: 1861 VLLQCEIQKKSTA 1873
Score = 65.3 bits (152), Expect = 2e-09
Identities = 133/676 (19%), Positives = 282/676 (41%), Gaps = 60/676 (8%)
Query: 213 DTKQQMTKMQENFIAMEAEWKDEK--QRLLKD-IESKDVRISSLEEA-NKLLEAARFEIS 268
+ + + ++EN + + ++ +R L+D ++ KD+ ++ LE+ NKL+E R +
Sbjct: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
Query: 269 LEHS--KLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEK-TEIE---EKGSLEIANMT 322
E KL +++E+ KQ IE K TEI+ + +L + +T
Sbjct: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLK-EKQKIELEARRKITEIQYTCRENALPVCPIT 1341
Query: 323 ELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKKGSPLISRKSGRNTASKM 382
+ T + +Q +EL+ ++ + ++ ++K + + A ++
Sbjct: 1342 QATSCRAVTGLQQEHDKQKAEELKQQVDEL-------TAANRKAEQDMRELTYELNALQL 1394
Query: 383 KSPWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVDKEYVISEKDTXXXXXXXXX 442
+ S+ + L D+ N KLE+ KD +K Y ++
Sbjct: 1395 EKTSSEEKARLLKDKLDETNNTLRCLKLELE----RKDQAEKGYSQQLRELGRQLNQTTG 1450
Query: 443 XGKDTL--IAQLQ-LEHQQHMEGPSLIHV-GTNTEDVNEIAK---VQEQLKQELNDEIKD 495
++ + + L+ ++ +E SL H G +V+ I + V E+ Q LN +I
Sbjct: 1451 KAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHS 1510
Query: 496 VNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNK 555
+ +E+L+ + + L ++ + +H+ L+ ++ +N K+ N+
Sbjct: 1511 FRDEKELERLQICQRKSDHLKEQFE----------KSHEQLLQNIKAEKENNDKIQRLNE 1560
Query: 556 EIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
E+ + E L QKV EL + +L + + E+ V +K + +++A
Sbjct: 1561 ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES--ENIVLEKQTIQQRCEALKIQA 1618
Query: 616 ISLLESQKFDLVQELHILQQKYDEVEDKLADISQ--LQSDQVCSEIKSVHLEEQIDALSA 673
+ Q + LH + + + K+ + + +S + SE K ++Q +
Sbjct: 1619 DG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ-KCDQQNIIIQN 1676
Query: 674 SKKELALVIENLKLDKEQ-LYGTIK-DLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEK 731
+KKE+ + L KE+ G K L+ + +N +Q+ + L E+M+ K
Sbjct: 1677 TKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRK 1736
Query: 732 ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN----IESELSKYKSRICRLEESIAV 787
+ + +QS + + ++ K+ E + EN I + + R +E+ +
Sbjct: 1737 MVLFQEESGKFKQSAEEFRKKME-KLMESKVITENDISGIRLDFVSLQQENSRAQENAKL 1795
Query: 788 MEDRRYSLERKADQLGSYLQEKQ----KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLE 843
E LER+ Q +Q+ Q Y + EDEL+ + + + + +++Q+ E
Sbjct: 1796 CETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKE 1855
Query: 844 IEHE----NKELQKKN 855
EH+ E+QKK+
Sbjct: 1856 HEHQLVLLQCEIQKKS 1871
Score = 59.3 bits (137), Expect = 1e-07
Identities = 147/860 (17%), Positives = 351/860 (40%), Gaps = 68/860 (7%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
IEN+ S L +++S + + +ED + +D++ +E+ + + + D+L
Sbjct: 882 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL------LEENQNLQISLSDMQ-QHY 876
V R + H + ++ +L ++E K L+ +++ + Q + + Q ++
Sbjct: 942 VERWQNV--HVQ-IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 998
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRIT-----HEHQTLIVQKKKEIEDLEIE 931
L + N+ + SE Q+++ + + ++ + +E QT+ + + +
Sbjct: 999 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1058
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
+++S+ ++ E + Y + Q K ++L EE K E +
Sbjct: 1059 KRRRMQSSA--DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH 1116
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLA 1051
Q T + E +KL + + + + L ++ + + + E++L
Sbjct: 1117 GAYSDLLQRQKAT---VLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
Query: 1052 QFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETK-LTFEMNIPKTE 1110
+ +E++ +Q++ + ++KQ+ EL+ +VRE++ +EL+ + LT E +
Sbjct: 1174 KQQRNVEDI--SLQKIRAE-SEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKR-- 1228
Query: 1111 GMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQE--EEEFIQERSVLQEQSAKLNTEL 1168
++ E + + N ++ LK ++ + Q+++ L E+ +
Sbjct: 1229 ----AAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE 1284
Query: 1169 QECYTKIIQLE---TLNTELTGHDVVNQEQIN-QLKSKLEQLN-TENDNLLS----TVAE 1219
+E I Q+E ++ + +++I + + K+ ++ T +N L T A
Sbjct: 1285 EELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQAT 1344
Query: 1220 LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR---VQLSAFESKYEQLLDSVQ 1276
+++ + + AE KQ + + A +K E ++R +L+A + + + +
Sbjct: 1345 SCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKAR 1404
Query: 1277 --SSTQEETNKIVTMEQVTSLQNKLQDKE---EHLRNLQEKYADVINQIEILRSEIEDEK 1331
+ETN + ++ L+ K Q ++ + LR L + + E E D K
Sbjct: 1405 LLKDKLDETNNTLRCLKL-ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLK 1463
Query: 1332 VAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
L+ E + + NI N+Q+
Sbjct: 1464 -KIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQI 1522
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDL 1451
R +D + E +H+ L++ + ++ ++ + + N+E E + ++++E+L
Sbjct: 1523 CQRKSDHLKEQFEKSHEQLLQNIKAEKENND---KIQRLNEELEKSNECAEMLKQKVEEL 1579
Query: 1452 TYE-KESELAILRLKMH-EN-ANHYETMQKESEIERVKL------IEELNVKITESVSLN 1502
T + E++L + R++ EN +T+Q+ E +++ + N + +
Sbjct: 1580 TRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTE 1639
Query: 1503 KQVAELNKALEEEVAKT----NEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHV 1558
+ K LEE++AK+ +E + + Q I I E+ NL + AS + ++
Sbjct: 1640 QDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEE-KRRG 1698
Query: 1559 SFASDTKQGRDEQLDNTMNK 1578
+Q + ++L+N + K
Sbjct: 1699 EQKVQLQQAQVQELNNRLKK 1718
>X63105-1|CAA44819.1| 726|Homo sapiens Tpr protein.
Length = 726
Score = 82.6 bits (195), Expect = 1e-14
Identities = 128/595 (21%), Positives = 266/595 (44%), Gaps = 48/595 (8%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ L++ E+E+ + IRD++V + + E ++Q L Y+ NIE L
Sbjct: 501 RVLLM----ELEE------ARGNHVIRDEEVSSADISSSSEVISQ---HLVSYR-NIEEL 546
Query: 975 NMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYI---NEINKLNALLKQKDEEI 1025
+ L EL + + ++Q+T S TE + + + +L L K + ++
Sbjct: 547 QQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601
Score = 72.5 bits (170), Expect = 1e-11
Identities = 124/618 (20%), Positives = 259/618 (41%), Gaps = 49/618 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ---FGIDAKIQERDLY 763
+NKL +Q +KLEK A++ SE+ E+ K++++ F I+ ++
Sbjct: 14 LNKLPKSVQ------NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
+ N E + + +L + + ++ LE D+ S++T ++EL
Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDR-------NIAIQSQFTRTKEEL 120
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN---LQISLSDMQQHYNALV 880
A D R E+ E+E+ +++++ N+ L E N LQ+ L ++Q ++
Sbjct: 121 E---AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
Query: 881 EKANRTD----LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQI 936
+ R + L S++T T+L+ L + E I++ K +E+ + E + ++
Sbjct: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVS-RL 236
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
E + K NE +K++E L +L+E K + +M + N++N + ++ K
Sbjct: 237 EEQMNGLKTSNEHLQKHVE---DLLTKLKEAKE--QQASMEEKFHNELNAHIKLSNLYKS 291
Query: 997 QTQSPDY-TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + +L+ LLK+ E A+ + + S M + K+ +
Sbjct: 292 AADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK 351
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNI-PKTEGMI 1113
+LEN + + ++ + EEL + K +K KLT N +T+ +
Sbjct: 352 ELENANDLLSATKRK--GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
+ +E + +D LK Q EE ER+ Q+ A L+ +L++
Sbjct: 410 LLEKLENKRIN-KYLDEIVKEVEAKAPILKRQREE---YERA--QKAVASLSVKLEQAMK 463
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
+I +L+ + V + +++ +++ L+ + LL + E R + ++
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
+ ++Q ++ E EL+ Q +L T+E + T ++T
Sbjct: 524 ADISSSSEVISQHLVSYRNIE-ELQQQNQRLLVALREL-----GETREREEQETTSSKIT 577
Query: 1294 SLQNKLQDKEEHLRNLQE 1311
LQ KL+ L L++
Sbjct: 578 ELQLKLESALTELEQLRK 595
Score = 71.7 bits (168), Expect = 2e-11
Identities = 113/562 (20%), Positives = 235/562 (41%), Gaps = 36/562 (6%)
Query: 634 QQKYDEVEDKLADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLD 688
+Q+Y E+E +L+ SQ + E +S+ LE Q+ AL+ KEL + +
Sbjct: 51 EQQYFEIEKRLSH-SQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAI 109
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
+ Q T ++LE +K D++ + QE LT+ +++++ EK+ E E Q K+
Sbjct: 110 QSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLN-EKLKE-SNTTKGELQLKLD 167
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
D ++ R+ + +E E S+ L + D +L R+ L+
Sbjct: 168 ELQASDVSVKYRE---KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC 224
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ E + +E +N L +H + + LL E KE Q + N I
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL---ESNLKRITHEHQTLIVQKKKEI 925
LS++ + A+ ++ +E T+ +L L + +H + Q K ++
Sbjct: 285 LSNLYK------SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM 338
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN 985
E +E ++E + + L ++ +++ E + V ++ K
Sbjct: 339 EKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAA------MSPTAAAVAKIVKPG 392
Query: 986 LELIDKHVQKQQTQSPDYTEQYINE-INK-LNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
++L + + +TQ E+ N+ INK L+ ++K+ + + L ++ + + V
Sbjct: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERA-QKAV 451
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK----ELKETK 1099
+ KL Q +++ ++E+ + +KQ ++ N ++I V++ QI+ EL+E +
Sbjct: 452 ASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSD---DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + ISS+ E +S N++ L+ E +E+
Sbjct: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
Query: 1157 LQEQSAKLNTELQECYTKIIQL 1178
+ +L +L+ T++ QL
Sbjct: 572 TSSKITELQLKLESALTELEQL 593
Score = 69.3 bits (162), Expect = 1e-10
Identities = 130/688 (18%), Positives = 290/688 (42%), Gaps = 56/688 (8%)
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT---QIESAIRDKKVLNE 948
E + +L L + LK +T +++ L + + + I ++ +F ++E+ RD NE
Sbjct: 74 ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA-IQSQFTRTKEELEAEKRDLIRTNE 132
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+ + +EY+T+ +L E K N +L L+ D V+ ++ + E
Sbjct: 133 RLSQELEYLTEDVKRLNE-KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
++ LN LK K +E++AL ++ N ++ + LEN +EE+ R+
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGN--------------EILELKCNLENKKEEVSRLE 237
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPMSDD-- 1124
+Q+ K NE LQ V + ++KE KE + + E + +S+ + +DD
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA-KLNTELQECYTKI-IQLETLN 1182
A + + + E + IQ+ + EQS ++ E+ E ++ +LE N
Sbjct: 298 AKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
Query: 1183 TELTGHD----VVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAEL 1238
L+ ++++E++ + S + + EL ++ DQ E E
Sbjct: 358 DLLSATKRKGAILSEEELAAM-SPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLEN 416
Query: 1239 WK--QHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQ 1296
+ ++L + + + L+ Q +E + ++ + S+ ++ +I +++ T
Sbjct: 417 KRINKYLDEIVKEVEAKAPILKRQREEYE-RAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475
Query: 1297 NKLQD-KEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTE 1355
NK E R ++ + D+ QI +L E+E+ + ++ ++
Sbjct: 476 NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQ 535
Query: 1356 N-QSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDS 1414
+ SY+ ++E + ++N +L + ++ L+L + L +
Sbjct: 536 HLVSYRNIEE-----LQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTEL 590
Query: 1415 EIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYE 1474
E +K+ ++ + L ++ + L+ + + + + +
Sbjct: 591 EQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD----DVSLASTPKRPS 646
Query: 1475 TMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIV 1534
T Q S V +IE + + E+ + KQ+ E+ + ++E A+ ++Q N+++E
Sbjct: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQ----NEQLE-- 698
Query: 1535 TLNDEITNLQNMVRASSSKIQKHVSFAS 1562
L +++T+L R+ ++KI + FAS
Sbjct: 699 KLQEQVTDL----RSQNTKISTQLDFAS 722
Score = 48.0 bits (109), Expect = 3e-04
Identities = 87/429 (20%), Positives = 170/429 (39%), Gaps = 23/429 (5%)
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE-QINQLKS 1201
KV+ E+++ + L +L E +EC + ++LE LN +L N+E +I Q ++
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN 106
Query: 1202 KL--EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR- 1258
Q + L + +L + + + ++ + + +E++ K E +L+
Sbjct: 107 IAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166
Query: 1259 --VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+Q S KY + + N + E T L E + E ++
Sbjct: 167 DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
N+ E + S +E++ L+ + M+E+ NE NA
Sbjct: 227 ENKKEEV-SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF---HNELNAH 282
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE- 1435
+K S+ + N+ V EL H+L + E + ++ + + Q D+ E
Sbjct: 283 IKLSN-LYKSAADDSEAKSNELTRAVEEL-HKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
Query: 1436 NVRQQLVEYEKRIE---DLTYEKESELAILRLKMHENANHYETMQKESEIER--VKLIEE 1490
+ +++ EK +E DL + + AI L E A T ++I + +KL E
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAI--LSEEELAAMSPTAAAVAKIVKPGMKLTEL 398
Query: 1491 LN--VKITESVSLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
N V+ + + L K + +NK L+E V + L+ Q E + +L +
Sbjct: 399 YNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKL 458
Query: 1548 RASSSKIQK 1556
+ +IQ+
Sbjct: 459 EQAMKEIQR 467
Score = 34.7 bits (76), Expect = 2.8
Identities = 86/483 (17%), Positives = 184/483 (38%), Gaps = 18/483 (3%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
LS ++ + L K+K TT +LQ K++E ++A + +
Sbjct: 134 LSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE----LQASDVSVKYREKRLEQEKEL 189
Query: 207 XXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFE 266
++ + +A+ E +E L ++E+K +S LEE L+ +
Sbjct: 190 LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
+ L +L++ I+ S K+ ++ A ELT+
Sbjct: 250 LQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----AKSNELTR 305
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSP--SKKGSPLISRKSGRNTASKMKS 384
+E L L + + NK +++ L + + K G ++ + S K
Sbjct: 306 AVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKR 365
Query: 385 PWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVD-KEYVISEK-DTXXXXXXXXX 442
+ LS E L + +I K M + L V+ ++ ++ EK +
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE 425
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
K+ L+ Q+ + V + + + + K ++L+++ + K +V L
Sbjct: 426 IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--LE 483
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT-IDNFSKVSDSNKEIVRLT 561
+ E Q+ L+ +I + + + NH ++ +++ I + S+V + R
Sbjct: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNI 543
Query: 562 EELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESD--VYKKMIEMENLAETRLKAISL 618
EEL +Q++ E G + + S ++ E + + E+E L ++R + L
Sbjct: 544 EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQL 603
Query: 619 LES 621
++S
Sbjct: 604 VDS 606
>BC094764-1|AAH94764.1| 692|Homo sapiens TPR protein protein.
Length = 692
Score = 82.6 bits (195), Expect = 1e-14
Identities = 128/595 (21%), Positives = 266/595 (44%), Gaps = 48/595 (8%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ L++ E+E+ + IRD++V + + E ++Q L Y+ NIE L
Sbjct: 501 RVLLM----ELEE------ARGNHVIRDEEVSSADISSSSEVISQ---HLVSYR-NIEEL 546
Query: 975 NMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYI---NEINKLNALLKQKDEEI 1025
+ L EL + + ++Q+T S TE + + + +L L K + ++
Sbjct: 547 QQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601
Score = 72.5 bits (170), Expect = 1e-11
Identities = 124/618 (20%), Positives = 259/618 (41%), Gaps = 49/618 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ---FGIDAKIQERDLY 763
+NKL +Q +KLEK A++ SE+ E+ K++++ F I+ ++
Sbjct: 14 LNKLPKSVQ------NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
+ N E + + +L + + ++ LE D+ S++T ++EL
Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDR-------NIAIQSQFTRTKEEL 120
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN---LQISLSDMQQHYNALV 880
A D R E+ E+E+ +++++ N+ L E N LQ+ L ++Q ++
Sbjct: 121 E---AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
Query: 881 EKANRTD----LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQI 936
+ R + L S++T T+L+ L + E I++ K +E+ + E + ++
Sbjct: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVS-RL 236
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
E + K NE +K++E L +L+E K + +M + N++N + ++ K
Sbjct: 237 EEQMNGLKTSNEHLQKHVE---DLLTKLKEAKE--QQASMEEKFHNELNAHIKLSNLYKS 291
Query: 997 QTQSPDY-TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + +L+ LLK+ E A+ + + S M + K+ +
Sbjct: 292 AADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK 351
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNI-PKTEGMI 1113
+LEN + + ++ + EEL + K +K KLT N +T+ +
Sbjct: 352 ELENANDLLSATKRK--GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
+ +E + +D LK Q EE ER+ Q+ A L+ +L++
Sbjct: 410 LLEKLENKRIN-KYLDEIVKEVEAKAPILKRQREE---YERA--QKAVASLSVKLEQAMK 463
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
+I +L+ + V + +++ +++ L+ + LL + E R + ++
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
+ ++Q ++ E EL+ Q +L T+E + T ++T
Sbjct: 524 ADISSSSEVISQHLVSYRNIE-ELQQQNQRLLVALREL-----GETREREEQETTSSKIT 577
Query: 1294 SLQNKLQDKEEHLRNLQE 1311
LQ KL+ L L++
Sbjct: 578 ELQLKLESALTELEQLRK 595
Score = 71.7 bits (168), Expect = 2e-11
Identities = 113/562 (20%), Positives = 235/562 (41%), Gaps = 36/562 (6%)
Query: 634 QQKYDEVEDKLADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLD 688
+Q+Y E+E +L+ SQ + E +S+ LE Q+ AL+ KEL + +
Sbjct: 51 EQQYFEIEKRLSH-SQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAI 109
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
+ Q T ++LE +K D++ + QE LT+ +++++ EK+ E E Q K+
Sbjct: 110 QSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLN-EKLKE-SNTTKGELQLKLD 167
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
D ++ R+ + +E E S+ L + D +L R+ L+
Sbjct: 168 ELQASDVSVKYRE---KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC 224
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ E + +E +N L +H + + LL E KE Q + N I
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL---ESNLKRITHEHQTLIVQKKKEI 925
LS++ + A+ ++ +E T+ +L L + +H + Q K ++
Sbjct: 285 LSNLYK------SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM 338
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN 985
E +E ++E + + L ++ +++ E + V ++ K
Sbjct: 339 EKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAA------MSPTAAAVAKIVKPG 392
Query: 986 LELIDKHVQKQQTQSPDYTEQYINE-INK-LNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
++L + + +TQ E+ N+ INK L+ ++K+ + + L ++ + + V
Sbjct: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERA-QKAV 451
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK----ELKETK 1099
+ KL Q +++ ++E+ + +KQ ++ N ++I V++ QI+ EL+E +
Sbjct: 452 ASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSD---DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + ISS+ E +S N++ L+ E +E+
Sbjct: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
Query: 1157 LQEQSAKLNTELQECYTKIIQL 1178
+ +L +L+ T++ QL
Sbjct: 572 TSSKITELQLKLESALTELEQL 593
Score = 64.9 bits (151), Expect = 2e-09
Identities = 114/567 (20%), Positives = 235/567 (41%), Gaps = 49/567 (8%)
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT---QIESAIRDKKVLNE 948
E + +L L + LK +T +++ L + + + I ++ +F ++E+ RD NE
Sbjct: 74 ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA-IQSQFTRTKEELEAEKRDLIRTNE 132
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+ + +EY+T+ +L E K N +L L+ D V+ ++ + E
Sbjct: 133 RLSQELEYLTEDVKRLNE-KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
++ LN LK K +E++AL ++ N ++ + LEN +EE+ R+
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGN--------------EILELKCNLENKKEEVSRLE 237
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPMSDD-- 1124
+Q+ K NE LQ V + ++KE KE + + E + +S+ + +DD
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA-KLNTELQECYTKI-IQLETLN 1182
A + + + E + IQ+ + EQS ++ E+ E ++ +LE N
Sbjct: 298 AKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
Query: 1183 TELTGHD----VVNQEQINQLK------SKLEQLNTENDNLLSTVAELRSS-ISSAVDQR 1231
L+ ++++E++ + +K+ + + L + E + + ++ +
Sbjct: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK 417
Query: 1232 GFE--IAELWKQHLAQREADFQKTEHELRVQ--LSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ E+ K+ A+ ++ E R Q +++ K EQ + +Q QE+T+K
Sbjct: 418 RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ-RLQEDTDKAN 476
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXXX 1345
V N+ E +++L ++ ++ ++E R I DE+V+
Sbjct: 477 KQSSVLERDNRRM--EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
Query: 1346 XXXXXDLRTEN-QSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
E Q Q ++ + E E + + +S + + E
Sbjct: 535 QHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR 594
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQ 1429
HQ++L DS + Q+ Y I L+Q
Sbjct: 595 KSRQHQMQLVDSIVRQR-DMYRILLSQ 620
Score = 48.0 bits (109), Expect = 3e-04
Identities = 87/429 (20%), Positives = 170/429 (39%), Gaps = 23/429 (5%)
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE-QINQLKS 1201
KV+ E+++ + L +L E +EC + ++LE LN +L N+E +I Q ++
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN 106
Query: 1202 KL--EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR- 1258
Q + L + +L + + + ++ + + +E++ K E +L+
Sbjct: 107 IAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166
Query: 1259 --VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+Q S KY + + N + E T L E + E ++
Sbjct: 167 DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
N+ E + S +E++ L+ + M+E+ NE NA
Sbjct: 227 ENKKEEV-SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF---HNELNAH 282
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE- 1435
+K S+ + N+ V EL H+L + E + ++ + + Q D+ E
Sbjct: 283 IKLSN-LYKSAADDSEAKSNELTRAVEEL-HKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
Query: 1436 NVRQQLVEYEKRIE---DLTYEKESELAILRLKMHENANHYETMQKESEIER--VKLIEE 1490
+ +++ EK +E DL + + AI L E A T ++I + +KL E
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAI--LSEEELAAMSPTAAAVAKIVKPGMKLTEL 398
Query: 1491 LN--VKITESVSLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
N V+ + + L K + +NK L+E V + L+ Q E + +L +
Sbjct: 399 YNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKL 458
Query: 1548 RASSSKIQK 1556
+ +IQ+
Sbjct: 459 EQAMKEIQR 467
Score = 34.7 bits (76), Expect = 2.8
Identities = 86/483 (17%), Positives = 184/483 (38%), Gaps = 18/483 (3%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
LS ++ + L K+K TT +LQ K++E ++A + +
Sbjct: 134 LSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE----LQASDVSVKYREKRLEQEKEL 189
Query: 207 XXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFE 266
++ + +A+ E +E L ++E+K +S LEE L+ +
Sbjct: 190 LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
+ L +L++ I+ S K+ ++ A ELT+
Sbjct: 250 LQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----AKSNELTR 305
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSP--SKKGSPLISRKSGRNTASKMKS 384
+E L L + + NK +++ L + + K G ++ + S K
Sbjct: 306 AVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKR 365
Query: 385 PWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVD-KEYVISEK-DTXXXXXXXXX 442
+ LS E L + +I K M + L V+ ++ ++ EK +
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE 425
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
K+ L+ Q+ + V + + + + K ++L+++ + K +V L
Sbjct: 426 IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--LE 483
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT-IDNFSKVSDSNKEIVRLT 561
+ E Q+ L+ +I + + + NH ++ +++ I + S+V + R
Sbjct: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNI 543
Query: 562 EELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESD--VYKKMIEMENLAETRLKAISL 618
EEL +Q++ E G + + S ++ E + + E+E L ++R + L
Sbjct: 544 EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQL 603
Query: 619 LES 621
++S
Sbjct: 604 VDS 606
>BC016514-1|AAH16514.1| 687|Homo sapiens TPR protein protein.
Length = 687
Score = 82.6 bits (195), Expect = 1e-14
Identities = 128/595 (21%), Positives = 266/595 (44%), Gaps = 48/595 (8%)
Query: 455 EHQQHMEGPSLIHVGTNTEDVNEIAKVQEQL---KQELNDEIKDVNVKDL-IEKLKSAEE 510
+ Q ++G H E + +++++L ++ L +E ++ L +EKL + +
Sbjct: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLK 90
Query: 511 QITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQ 569
+T+ N E++ A I ++S ++++ + + ++ ++E+ LTE++ L++
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE 150
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
K+ E KG LQL L + + + K++ + + L ++ ++ K D +
Sbjct: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA 210
Query: 630 L------HILQQKYDEVEDKLADISQLQSD----QVCSEIKSVHLEEQIDALSASKKELA 679
L IL+ K + +E+K ++S+L+ + +E H+E+ + L +K++ A
Sbjct: 211 LGREKGNEILELKCN-LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Query: 680 LVIENLKLDKE---QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELL 736
+ E + +L K +D E N+L ++E KL K + E +
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE----LHKLLKEAGEANKAIQ 325
Query: 737 AKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRL-EESIAVMEDRRYSL 795
+ EQSK Q + + KI + +EN LS K + L EE +A M ++
Sbjct: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV 385
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKN 855
K + G L E AY E +D+L+ ++ +++ + E+E + L+++
Sbjct: 386 -AKIVKPGMKLTELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 856 QILLEENQNLQISLS-DMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
+ E Q SLS ++Q + TD A +S+ + R +E +K ++ +
Sbjct: 442 E-EYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
+ L++ E+E+ + IRD++V + + E ++Q L Y+ NIE L
Sbjct: 501 RVLLM----ELEE------ARGNHVIRDEEVSSADISSSSEVISQ---HLVSYR-NIEEL 546
Query: 975 NMNVEELNKMNLELID-KHVQKQQTQSPDYTEQYI---NEINKLNALLKQKDEEI 1025
+ L EL + + ++Q+T S TE + + + +L L K + ++
Sbjct: 547 QQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601
Score = 72.5 bits (170), Expect = 1e-11
Identities = 124/618 (20%), Positives = 259/618 (41%), Gaps = 49/618 (7%)
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ---FGIDAKIQERDLY 763
+NKL +Q +KLEK A++ SE+ E+ K++++ F I+ ++
Sbjct: 14 LNKLPKSVQ------NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
+ N E + + +L + + ++ LE D+ S++T ++EL
Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDR-------NIAIQSQFTRTKEEL 120
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQN---LQISLSDMQQHYNALV 880
A D R E+ E+E+ +++++ N+ L E N LQ+ L ++Q ++
Sbjct: 121 E---AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
Query: 881 EKANRTD----LAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQI 936
+ R + L S++T T+L+ L + E I++ K +E+ + E + ++
Sbjct: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVS-RL 236
Query: 937 ESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQ 996
E + K NE +K++E L +L+E K + +M + N++N + ++ K
Sbjct: 237 EEQMNGLKTSNEHLQKHVE---DLLTKLKEAKE--QQASMEEKFHNELNAHIKLSNLYKS 291
Query: 997 QTQSPDY-TEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTT 1055
+ + + + +L+ LLK+ E A+ + + S M + K+ +
Sbjct: 292 AADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK 351
Query: 1056 KLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE-TKLTFEMNI-PKTEGMI 1113
+LEN + + ++ + EEL + K +K KLT N +T+ +
Sbjct: 352 ELENANDLLSATKRK--GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
Query: 1114 ISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYT 1173
+ +E + +D LK Q EE ER+ Q+ A L+ +L++
Sbjct: 410 LLEKLENKRIN-KYLDEIVKEVEAKAPILKRQREE---YERA--QKAVASLSVKLEQAMK 463
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGF 1233
+I +L+ + V + +++ +++ L+ + LL + E R + ++
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 1234 EIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVT 1293
+ ++Q ++ E EL+ Q +L T+E + T ++T
Sbjct: 524 ADISSSSEVISQHLVSYRNIE-ELQQQNQRLLVALREL-----GETREREEQETTSSKIT 577
Query: 1294 SLQNKLQDKEEHLRNLQE 1311
LQ KL+ L L++
Sbjct: 578 ELQLKLESALTELEQLRK 595
Score = 71.7 bits (168), Expect = 2e-11
Identities = 113/562 (20%), Positives = 235/562 (41%), Gaps = 36/562 (6%)
Query: 634 QQKYDEVEDKLADISQLQSDQVCSEIKSVHLE-----EQIDALSASKKELALVIENLKLD 688
+Q+Y E+E +L+ SQ + E +S+ LE Q+ AL+ KEL + +
Sbjct: 51 EQQYFEIEKRLSH-SQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAI 109
Query: 689 KEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
+ Q T ++LE +K D++ + QE LT+ +++++ EK+ E E Q K+
Sbjct: 110 QSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLN-EKLKE-SNTTKGELQLKLD 167
Query: 749 TQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQE 808
D ++ R+ + +E E S+ L + D +L R+ L+
Sbjct: 168 ELQASDVSVKYRE---KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC 224
Query: 809 KQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ E + +E +N L +H + + LL E KE Q + N I
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL---ESNLKRITHEHQTLIVQKKKEI 925
LS++ + A+ ++ +E T+ +L L + +H + Q K ++
Sbjct: 285 LSNLYK------SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM 338
Query: 926 EDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMN 985
E +E ++E + + L ++ +++ E + V ++ K
Sbjct: 339 EKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAA------MSPTAAAVAKIVKPG 392
Query: 986 LELIDKHVQKQQTQSPDYTEQYINE-INK-LNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
++L + + +TQ E+ N+ INK L+ ++K+ + + L ++ + + V
Sbjct: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERA-QKAV 451
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIK----ELKETK 1099
+ KL Q +++ ++E+ + +KQ ++ N ++I V++ QI+ EL+E +
Sbjct: 452 ASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
Query: 1100 LTFEMNIPKTEGMIISSTIEPMSD---DANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV 1156
+ + ISS+ E +S N++ L+ E +E+
Sbjct: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
Query: 1157 LQEQSAKLNTELQECYTKIIQL 1178
+ +L +L+ T++ QL
Sbjct: 572 TSSKITELQLKLESALTELEQL 593
Score = 64.9 bits (151), Expect = 2e-09
Identities = 114/567 (20%), Positives = 235/567 (41%), Gaps = 49/567 (8%)
Query: 892 ESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT---QIESAIRDKKVLNE 948
E + +L L + LK +T +++ L + + + I ++ +F ++E+ RD NE
Sbjct: 74 ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA-IQSQFTRTKEELEAEKRDLIRTNE 132
Query: 949 KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYI 1008
+ + +EY+T+ +L E K N +L L+ D V+ ++ + E
Sbjct: 133 RLSQELEYLTEDVKRLNE-KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 1009 NEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVS 1068
++ LN LK K +E++AL ++ N ++ + LEN +EE+ R+
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGN--------------EILELKCNLENKKEEVSRLE 237
Query: 1069 KQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK--TEGMIISSTIEPMSDD-- 1124
+Q+ K NE LQ V + ++KE KE + + E + +S+ + +DD
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
Query: 1125 ANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSA-KLNTELQECYTKI-IQLETLN 1182
A + + + E + IQ+ + EQS ++ E+ E ++ +LE N
Sbjct: 298 AKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
Query: 1183 TELTGHD----VVNQEQINQLK------SKLEQLNTENDNLLSTVAELRSS-ISSAVDQR 1231
L+ ++++E++ + +K+ + + L + E + + ++ +
Sbjct: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK 417
Query: 1232 GFE--IAELWKQHLAQREADFQKTEHELRVQ--LSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ E+ K+ A+ ++ E R Q +++ K EQ + +Q QE+T+K
Sbjct: 418 RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ-RLQEDTDKAN 476
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSE--IEDEKVAFXXXXXXXXXXX 1345
V N+ E +++L ++ ++ ++E R I DE+V+
Sbjct: 477 KQSSVLERDNRRM--EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
Query: 1346 XXXXXDLRTEN-QSYKQMQEQSILNINE--ENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
E Q Q ++ + E E + + +S + + E
Sbjct: 535 QHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR 594
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQ 1429
HQ++L DS + Q+ Y I L+Q
Sbjct: 595 KSRQHQMQLVDSIVRQR-DMYRILLSQ 620
Score = 48.0 bits (109), Expect = 3e-04
Identities = 87/429 (20%), Positives = 170/429 (39%), Gaps = 23/429 (5%)
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQE-QINQLKS 1201
KV+ E+++ + L +L E +EC + ++LE LN +L N+E +I Q ++
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRN 106
Query: 1202 KL--EQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELR- 1258
Q + L + +L + + + ++ + + +E++ K E +L+
Sbjct: 107 IAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166
Query: 1259 --VQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADV 1316
+Q S KY + + N + E T L E + E ++
Sbjct: 167 DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
Query: 1317 INQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQ 1376
N+ E + S +E++ L+ + M+E+ NE NA
Sbjct: 227 ENKKEEV-SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF---HNELNAH 282
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFE- 1435
+K S+ + N+ V EL H+L + E + ++ + + Q D+ E
Sbjct: 283 IKLSN-LYKSAADDSEAKSNELTRAVEEL-HKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
Query: 1436 NVRQQLVEYEKRIE---DLTYEKESELAILRLKMHENANHYETMQKESEIER--VKLIEE 1490
+ +++ EK +E DL + + AI L E A T ++I + +KL E
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAI--LSEEELAAMSPTAAAVAKIVKPGMKLTEL 398
Query: 1491 LN--VKITESVSLNK-QVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMV 1547
N V+ + + L K + +NK L+E V + L+ Q E + +L +
Sbjct: 399 YNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKL 458
Query: 1548 RASSSKIQK 1556
+ +IQ+
Sbjct: 459 EQAMKEIQR 467
Score = 34.7 bits (76), Expect = 2.8
Identities = 86/483 (17%), Positives = 184/483 (38%), Gaps = 18/483 (3%)
Query: 147 LSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXXX 206
LS ++ + L K+K TT +LQ K++E ++A + +
Sbjct: 134 LSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE----LQASDVSVKYREKRLEQEKEL 189
Query: 207 XXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARFE 266
++ + +A+ E +E L ++E+K +S LEE L+ +
Sbjct: 190 LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
Query: 267 ISLEHSKLAQELEQXXXXXXXXXXXXXXLAKQSIEPSCEEKTEIEEKGSLEIANMTELTK 326
+ L +L++ I+ S K+ ++ A ELT+
Sbjct: 250 LQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----AKSNELTR 305
Query: 327 KIELLEHLNCQIRQTNKELENKLATMGTESKAVSSP--SKKGSPLISRKSGRNTASKMKS 384
+E L L + + NK +++ L + + K G ++ + S K
Sbjct: 306 AVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKR 365
Query: 385 PWSQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVD-KEYVISEK-DTXXXXXXXXX 442
+ LS E L + +I K M + L V+ ++ ++ EK +
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE 425
Query: 443 XGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLI 502
K+ L+ Q+ + V + + + + K ++L+++ + K +V L
Sbjct: 426 IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--LE 483
Query: 503 EKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKT-IDNFSKVSDSNKEIVRLT 561
+ E Q+ L+ +I + + + NH ++ +++ I + S+V + R
Sbjct: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNI 543
Query: 562 EELHHLSQKVAELEEEKGNL-QLHLVDYDSGRMIESD--VYKKMIEMENLAETRLKAISL 618
EEL +Q++ E G + + S ++ E + + E+E L ++R + L
Sbjct: 544 EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQL 603
Query: 619 LES 621
++S
Sbjct: 604 VDS 606
>AK024959-1|BAB15043.1| 696|Homo sapiens protein ( Homo sapiens cDNA:
FLJ21306 fis, clone COL02125. ).
Length = 696
Score = 82.6 bits (195), Expect = 1e-14
Identities = 130/610 (21%), Positives = 267/610 (43%), Gaps = 49/610 (8%)
Query: 476 NEIAKVQEQLKQELNDEIKDVNVK-DLIEKLK-SAEEQITQLNDEIDAANKNMIKVKSNH 533
NE+ +E+ K ELN +I + L EK + +++ Q+ D A + KS +
Sbjct: 107 NELKNEKEE-KAELNKQIVHSQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 165
Query: 534 KLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRM 593
+ +Q +K + +++ + + I ++ + K+ EL Q+ +D + R
Sbjct: 166 Q---EQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRD 222
Query: 594 IESDVYKKMIEMENLAETRLKAIS---LLESQ-KFDLVQELHILQQKYDEVEDKLADISQ 649
+ + E +NL T+L + L+ Q K +QE + + +E + +
Sbjct: 223 LSNGS-----EEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKE 277
Query: 650 LQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNK 709
+ + LE+QI+ L A K EN +L KE+ + DL +KE ++ +
Sbjct: 278 IVKASSKKSHQIEELEQQIEKLQAEVK--GYKDENNRL-KEREHKNQDDLLKEKETLIQQ 334
Query: 710 LQNYIQE-NMDLTDKLEKMSAEK--ISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
L+ +QE N+ L +++ + K +SEL + + AKI+E + +E
Sbjct: 335 LKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK-----------AKIKELETILET 383
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
+ E +S +LE+ I E LER + +LQ+ K + ++E +L
Sbjct: 384 QKVE----RSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEE 439
Query: 827 LAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEK-ANR 885
+ L ++ + + K LL+++ E +E ++ L+E L S + Q L K +
Sbjct: 440 ITQLTNNLQDM-KHLLQLKEEEEETNRQETEKLKE--ELSASSARTQNLKADLQRKEEDY 496
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKV 945
DL E + T + Q++ ++ + + E + L + K E+E + + + +++ R +
Sbjct: 497 ADLKE-KLTDAKKQIKQVQKEVSVMRDEDKLLRI-KINELEKKKNQCSQELDMKQRTIQQ 554
Query: 946 LNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTE 1005
L E+ ++E +Q+Y+ ++LN+ + + M + L ++ ++ Q + E
Sbjct: 555 LKEQLNNQ-----KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ--EQTQVEQDQVLE 607
Query: 1006 QYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQ 1065
+ E+ +L L++ E+ L K N +D KL +L+ E++
Sbjct: 608 AKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN 667
Query: 1066 RVSKQLLDSK 1075
K+ L+ K
Sbjct: 668 ADRKKWLEEK 677
Score = 74.5 bits (175), Expect = 3e-12
Identities = 139/691 (20%), Positives = 290/691 (41%), Gaps = 72/691 (10%)
Query: 880 VEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESA 939
V K +++ + + +L+ E K+ + + I + +K+ E++ +
Sbjct: 30 VPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPSI-----AE 84
Query: 940 IRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKH---VQKQ 996
I D +VL E E ++ +E +L+ K LN + ++ L L +K + K+
Sbjct: 85 IEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH-SQQELSLSEKKNLTLSKE 143
Query: 997 QTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE---SKLAQF 1053
Q + I E++ + ++++E+I+ L+ +I A S + VS + +K+ +
Sbjct: 144 VQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDEL 203
Query: 1054 TTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNI--PKTEG 1111
T L+++ + L D +EE + + D + +K E I P E
Sbjct: 204 RT-LDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNREN 262
Query: 1112 MIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQ------EEEEFIQERSVLQEQSAKLN 1165
SS IE + ++ + L+ Q E + + E + L+E+ K
Sbjct: 263 SFHSS-IEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEREHKNQ 321
Query: 1166 TELQECYTKIIQLETLNTELTGHDVVNQEQINQL---KSKLEQLNTENDNLLSTVAELRS 1222
+L + +IQ L EL +V QI + K L +L + + EL +
Sbjct: 322 DDLLKEKETLIQ--QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELET 379
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
+ + +R A+L +Q + ++E+ K E L+ F+ E L DSV+++
Sbjct: 380 ILETQKVERSHS-AKL-EQDILEKESIILKLERNLK----EFQ---EHLQDSVKNTKDLN 430
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXX 1342
++ E++T L N LQD +HL L+E+ + Q E EK+
Sbjct: 431 VKELKLKEEITQLTNNLQDM-KHLLQLKEEEEETNRQ--------ETEKL--KEELSASS 479
Query: 1343 XXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKV 1402
DL+ + + Y ++E+ + + ++ Q++K ++N+ E K
Sbjct: 480 ARTQNLKADLQRKEEDYADLKEK-LTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKK 538
Query: 1403 LELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAIL 1462
+ + +L++K I Q Q N+ + V + + +YE+ +DL KE + +
Sbjct: 539 NQCSQELDMKQRTIQQLKE-------QLNN--QKVEEAIQQYERACKDLNV-KEKIIEDM 588
Query: 1463 RLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEM 1522
R+ + E Q+++++E+ +++E K+ E L ++ + + + K N+
Sbjct: 589 RMTLEE--------QEQTQVEQDQVLE---AKLEEVERLATELEKWKEKCNDLETKNNQR 637
Query: 1523 QTALENQEIEIVTLNDEITNLQNMVRASSSK 1553
+++ ++TNLQ+ ++ S K
Sbjct: 638 SNKEHENNTDVL---GKLTNLQDELQESEQK 665
Score = 36.3 bits (80), Expect = 0.91
Identities = 30/129 (23%), Positives = 63/129 (48%), Gaps = 2/129 (1%)
Query: 1427 LTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVK 1486
+T+ + E VR + E E I L E A L +E N E + E + V
Sbjct: 68 ITEDQKKSEEVRPSIAEIED-IRVLQENNEGLRAFLLTIENELKNEKEE-KAELNKQIVH 125
Query: 1487 LIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
+EL++ ++++L+K+V ++ + +A+ + ++ + QE +I+ L++EI
Sbjct: 126 SQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRS 185
Query: 1547 VRASSSKIQ 1555
+ + S+I+
Sbjct: 186 ITNNVSQIK 194
Score = 33.1 bits (72), Expect = 8.5
Identities = 23/134 (17%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 146 HLSNTIKEKDNALSVLQVKMKIMETTILDLQEKINEKDQIIEAKNKATTXXXXXXXXXXX 205
HL +++K + L+V ++K+K T + + + + Q+ E + +
Sbjct: 418 HLQDSVKNTKD-LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELS 476
Query: 206 XXXXXXEDTKQQMTKMQENFIAMEAEWKDEKQRLLKDIESKDVRISSLEEANKLLEAARF 265
++ K + + +E++ ++ + D K+++ K ++ + +S + + +KLL
Sbjct: 477 ASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI-KQVQKE---VSVMRDEDKLLRIKIN 532
Query: 266 EISLEHSKLAQELE 279
E+ + ++ +QEL+
Sbjct: 533 ELEKKKNQCSQELD 546
>BC048203-1|AAH48203.1| 663|Homo sapiens Unknown (protein for
IMAGE:4139784) protein.
Length = 663
Score = 81.8 bits (193), Expect = 2e-14
Identities = 146/680 (21%), Positives = 298/680 (43%), Gaps = 55/680 (8%)
Query: 555 KEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLK 614
+E+ + ++ HL Q+ A L+++ ++ + M+E+ Y++ ++ + LK
Sbjct: 27 EELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKV--MVEA--YRRDATSKDQLISELK 82
Query: 615 AI-SLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSA 673
A L+S+ +L QEL Q + E A++S+L + LE + +
Sbjct: 83 ATRKRLDSELKELRQEL---MQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQK 139
Query: 674 SKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKIS 733
+ E+ +++L+ DKEQ+ + E K+ I +LQ + +T++ +KM ++
Sbjct: 140 ERDEMETHLQSLQFDKEQMVAVTEANEALKKQI-EELQQ--EARKAITEQKQKM--RRLG 194
Query: 734 ELLAKINHEEQSK---IQTQFGI-DAKIQERDLYIENIESELSKYKSRICRLEESIAVME 789
L E ++K + GI ++QE E ++EL + +++ + S+A+ E
Sbjct: 195 SDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHE 254
Query: 790 DRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENK 849
R +LE E Q T+ E EL +A+ +++LE+E E +
Sbjct: 255 -RIQALEA----------ELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQ 303
Query: 850 E---LQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESN 906
E +KK + L E N+ L + L + L + + L E S +T L E++
Sbjct: 304 ESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQ--SNAALREHNSI-LETALAKREAD 360
Query: 907 LKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQE 966
L ++ + Q ++ ++KE ED +++ Q A +K+ EK E V + +
Sbjct: 361 LVQLNLQVQAVL--QRKEEEDRQMKHLVQALQASLEKE--KEKVNSLKEQVAAAKVEAGH 416
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYT---EQYINEINKLNALLKQKDE 1023
+ + + ++ + E+ K L+ + VQK Q ++ D ++ EI + A L +
Sbjct: 417 NRRHFKAASLELSEVKK-ELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARA 475
Query: 1024 EIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQHNEELQ 1082
++ L ++++ Q+S + + ++ +++ E E+Q + +QL L +Q +EL+
Sbjct: 476 QLQLLQKQLDE-QLSKQPVGNQ---EMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELE 531
Query: 1083 ILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXL 1142
L + + EL+ + M K + M+ + +S+ NN+ L
Sbjct: 532 GLQQLLQNVKSELEMAQEDLSMT-QKDKFMLQAK----VSELKNNMKTLLQQNQQLKLDL 586
Query: 1143 KVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
+ + + + + ++ +C LE L L V++E + L S
Sbjct: 587 RRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEEL---LRPPPAVSKEPLKNLNSC 643
Query: 1203 LEQLNTENDNLLSTVAELRS 1222
L+QL E D+L + EL S
Sbjct: 644 LQQLKQEMDSLQRQMEELSS 663
Score = 74.9 bits (176), Expect = 2e-12
Identities = 115/535 (21%), Positives = 244/535 (45%), Gaps = 49/535 (9%)
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
++E+ +++L EL E++ ++ EK ++AE ++++L+ E+ ++M ++ + +
Sbjct: 78 ISELKATRKRLDSELK-ELRQELMQVHGEK-RTAEAELSRLHREVAQVRQHMADLEGHLQ 135
Query: 535 LKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMI 594
K+ + + + +++V +TE L +++ EL++E R +
Sbjct: 136 SAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITE--QKQKMRRL 193
Query: 595 ESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQLQSDQ 654
SD+ EM+ + A+ +L + LQ+ E A++ QL++ Q
Sbjct: 194 GSDLTSAQKEMKTKHKAYENAVGILSRR----------LQEALAAKEAADAELGQLRA-Q 242
Query: 655 VCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYG-TIKDLENDKEDIMNKLQNY 713
S S+ L E+I AL A + ++ L+ + +++ T ++LE +E ++ +L++
Sbjct: 243 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL-ELEDE 301
Query: 714 IQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSK 773
+QE+ K++++ E +L ++ H E+ K+ +A ++E + +E+ L+K
Sbjct: 302 LQESRGFRKKIKRLE-ESNKKLALELEH-EKGKLTGLGQSNAALREHN---SILETALAK 356
Query: 774 YKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDH 833
++ + +L + + R+ +R+ L LQ + E E V V H
Sbjct: 357 READLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH 416
Query: 834 DRVVEKQL-LEIEHENKELQKKNQILLEENQNLQISLSDMQ----QHYNALVEKANRTDL 888
+R K LE+ KELQ K ++ Q LQ D+Q +H + +
Sbjct: 417 NRRHFKAASLELSEVKKELQAKEHLV----QKLQAEADDLQIREGKHSQEIAQFQAELAE 472
Query: 889 AESESTKYQTQLRDLESNLKRITHEHQTL---IVQKKKEIEDLEIEFNTQIESAIRDKKV 945
A ++ Q QL + S E + L + QK++EI+ L+ + + + ++ +
Sbjct: 473 ARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG 532
Query: 946 L-----NEKYEKNIEY----VTQ-----LEAQLQEYKNNIENLNMNVEELNKMNL 986
L N K E + +TQ L+A++ E KNN++ L ++L K++L
Sbjct: 533 LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL-KLDL 586
Score = 53.6 bits (123), Expect = 6e-06
Identities = 84/548 (15%), Positives = 214/548 (39%), Gaps = 38/548 (6%)
Query: 1061 EEEMQRVSKQLLDSKQHNEELQILVREQ----DDQIKELKETKLTFEMNIPKTEGMIISS 1116
+EE+ R +++L + + E +RE+ Q++ L++ + + K + +
Sbjct: 1 KEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ 60
Query: 1117 TI--EPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTK 1174
+ E DA + D L E +E QE + + EL + +
Sbjct: 61 KVMVEAYRRDATSKDQLISELKATRKRLD-SELKELRQELMQVHGEKRTAEAELSRLHRE 119
Query: 1175 IIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFE 1234
+ Q+ +L GH Q++ +++++ L+ L + + +++ V E ++ +++ E
Sbjct: 120 VAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA-VTEANEALKKQIEELQQE 178
Query: 1235 IAEL---WKQHLAQREADFQKTEHELRVQLSAFES-------KYEQLLDSVQSSTQE--- 1281
+ KQ + + +D + E++ + A+E+ + ++ L + +++ E
Sbjct: 179 ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 238
Query: 1282 -------ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAF 1334
+ + E++ +L+ +LQ H + L EK + + E EKV
Sbjct: 239 LRAQGGSSDSSLALHERIQALEAELQ-AVSHSKTLLEKELQEVIALTSQELEESREKVLE 297
Query: 1335 XXXXXXXXXXXXXXXXDLRTENQSYK---QMQEQSILNINEENAQLKKSSXXXXXXXXXX 1391
L N+ + ++ + + + NA L++ +
Sbjct: 298 LEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKR 357
Query: 1392 XXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRNDEFENVRQQLVEYEKRI-ED 1450
+ +V + + E +D ++ +L + ++ ++++Q+ + +
Sbjct: 358 EADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHN 417
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIE-----ELNVKITESVSLNKQV 1505
+ K + L + +K A + + ++E + +++ E E+ E Q+
Sbjct: 418 RRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQL 477
Query: 1506 AELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFASDTK 1565
L K L+E+++K +EN + E+ EI +L+ + + + +K +
Sbjct: 478 QLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLL 537
Query: 1566 QGRDEQLD 1573
Q +L+
Sbjct: 538 QNVKSELE 545
Score = 41.1 bits (92), Expect = 0.032
Identities = 87/547 (15%), Positives = 218/547 (39%), Gaps = 42/547 (7%)
Query: 844 IEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDL 903
+E +EL K+ + Q MQ+ +++ + ++T + +L
Sbjct: 22 LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 81
Query: 904 ESNLKRITHEHQTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQ 963
++ KR+ E KE+ ++ + + +A + L+ + + +++ LE
Sbjct: 82 KATRKRLDSE--------LKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGH 133
Query: 964 LQEYKNNIENLNMNVEEL--NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQK 1021
LQ + + + +++ L +K + + + + + Q + ++ I + +++
Sbjct: 134 LQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRL 193
Query: 1022 DEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL 1081
++ + +++ +Y + V +L + E + E+ ++ Q S + L
Sbjct: 194 GSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQG-GSSDSSLAL 252
Query: 1082 QILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXX 1141
++ + +++ + +K E + + +I+ T + + + V
Sbjct: 253 HERIQALEAELQAVSHSKTLLEKELQE----VIALTSQELEESREKVLELED-------- 300
Query: 1142 LKVQEEEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKS 1201
++QE F ++ L+E + KL EL+ K+ L N L H+ + + + + ++
Sbjct: 301 -ELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREA 359
Query: 1202 KLEQLNTENDNLLSTVAE-------LRSSISSAVDQRGFEIAELWKQHLAQREADFQKTE 1254
L QLN + +L E L ++ +++++ ++ L +Q A +
Sbjct: 360 DLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRR 419
Query: 1255 HELRVQLSAFESKYE-QLLDSVQSSTQEETNKIVTME-----QVTSLQNKLQDKEEHLRN 1308
H L E K E Q + + Q E + + E ++ Q +L + L+
Sbjct: 420 HFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQL 479
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQ--EQS 1366
LQ++ + +++ + E+E+ K + DL TE Q K+++ +Q
Sbjct: 480 LQKQLDEQLSKQPVGNQEMENLK--WEVDQKEREIQSLKQQLDL-TEQQGRKELEGLQQL 536
Query: 1367 ILNINEE 1373
+ N+ E
Sbjct: 537 LQNVKSE 543
>AF485338-1|AAL93149.1| 1498|Homo sapiens golgin-160 protein.
Length = 1498
Score = 81.4 bits (192), Expect = 2e-14
Identities = 163/785 (20%), Positives = 340/785 (43%), Gaps = 63/785 (8%)
Query: 451 QLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEE 510
QL+ Q+H++ L+ T T++ + + Q DE++ + +L + S E+
Sbjct: 711 QLEALQQEHLD---LMKQLTLTQEALQSREQSLDALQTRYDELQ-ARLGELQGEAASRED 766
Query: 511 QITQLNDE---IDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTE-ELHH 566
I L +E ++AA + K +++++ + S+ + +E + + ++ H
Sbjct: 767 TICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEH 826
Query: 567 LSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI-SLLESQKFD 625
L Q+ A L+++ ++ + M+E+ Y++ ++ + LKA L+S+ +
Sbjct: 827 LQQETAALKKQMQKIKEQFLQQKV--MVEA--YRRDATSKDQLISELKATRKRLDSELKE 882
Query: 626 LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENL 685
L QEL Q + E A++S+L + LE + + + E+ +++L
Sbjct: 883 LRQEL---MQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEVETHLQSL 939
Query: 686 KLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQS 745
+ DKEQ+ + E K+ I +LQ + +T++ +KM ++ L E ++
Sbjct: 940 QFDKEQMVAVTEANEALKKQI-EELQQ--EARKAITEQKQKM--RRLGSDLTSAQKEMKT 994
Query: 746 K---IQTQFGI-DAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ 801
K + GI ++QE E ++EL + +++ + S+A+ E R +LE
Sbjct: 995 KHKAYENAVGILSRRLQEALAAREAADAELGQLRAQGGSSDSSLALHE-RIQALEA---- 1049
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKE---LQKKNQIL 858
E Q T+ E EL +A+ +++LE+E E +E +KK + L
Sbjct: 1050 ------ELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRL 1103
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
E N+ L + L + L + + L E S +T L E++L ++ + Q ++
Sbjct: 1104 EESNKKLALELEHEKGKLTGLGQ--SNAALREHNSI-LETALAKREADLVQLNLQVQAVL 1160
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNV 978
++KE ED +++ Q A +K+ EK E V + + + + + ++ +
Sbjct: 1161 --QRKEEEDRQMKHLVQALQASLEKE--KEKVNSLKEQVAAAKVEAGHNRRHFKAASLEL 1216
Query: 979 EELNKMNLELIDKHVQKQQTQSPDYT---EQYINEINKLNALLKQKDEEIIALNQKINNA 1035
E+ K L+ + VQK Q ++ D ++ EI + A L + ++ L ++++
Sbjct: 1217 SEVKK-ELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ 1275
Query: 1036 QVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQL-LDSKQHNEELQILVREQDDQIKE 1094
+S ++ +++ E E+Q + +QL L +Q +EL+ L + + E
Sbjct: 1276 ----LSKQPAGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGWKELEGLQQLLQNVKSE 1331
Query: 1095 LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
L+ + M K + M+ + +S+ NN+ L+ + + +
Sbjct: 1332 LEMAQEDLSMT-QKDKFMLQAK----VSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPK 1386
Query: 1155 SVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLL 1214
+ ++ +C LE L L V++E + L S L+QL E D+L
Sbjct: 1387 GEASSSNPATPIKIPDCPVPASLLEEL---LRPPPAVSKEPLKNLNSCLQQLKQEMDSLR 1443
Query: 1215 STVAE 1219
+ E
Sbjct: 1444 RQMEE 1448
Score = 78.2 bits (184), Expect = 2e-13
Identities = 157/939 (16%), Positives = 379/939 (40%), Gaps = 52/939 (5%)
Query: 479 AKVQEQLKQELNDEIK-DVNVKDLIEKLKSAEEQITQLNDEIDA-ANKNMIKVKSNHKLK 536
A+ QE++ Q L ++++ + ++ L + A ++ +L ++ A + K +V+ +H +
Sbjct: 401 AETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQ 460
Query: 537 LKQMQKTIDNFSKVSDSNKEIVRLTEELHH-LSQKVAELEEEKGNLQLHLVDYDSGRMIE 595
+Q + S ++ R +L + L K A L +LQ+ Y
Sbjct: 461 QRQ-DSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKV 519
Query: 596 SDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADISQL----Q 651
D+ + M+ +N + ++ L+SQ + E L K + +++ + + Q
Sbjct: 520 EDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQ 579
Query: 652 SDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQ 711
++ V L+ ++ + + A ++E+LKL+ L + + ++ ++
Sbjct: 580 QQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIA 639
Query: 712 NYIQE-NMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESE 770
+Q D+ D ++ + +I E + + Q +++ G ++Q ++E +
Sbjct: 640 AQLQGIEADMLD--QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQ 697
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
L + K + + ++ + ++ L ++ LQ ++++ + DEL RL L
Sbjct: 698 LEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTRYDELQARLGEL 757
Query: 831 MDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDMQQHYNALVEKANRTDLAE 890
E + +++E L+ Q + L +++ E +
Sbjct: 758 QGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREEL 817
Query: 891 SESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEFNT--QIESAIR-DKKVLN 947
+ + L+ + LK+ + + +Q+K +E + + Q+ S ++ +K L+
Sbjct: 818 AIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLD 877
Query: 948 EKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQY 1007
+ ++ + + Q+ + + + + L+ V ++ + +L + H+Q Q + D E +
Sbjct: 878 SELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADL-EGHLQSAQKER-DEVETH 935
Query: 1008 INEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRV 1067
+ + + E AL ++I Q +++ + K+ + + L + ++EM+
Sbjct: 936 LQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTK 995
Query: 1068 SKQLLDSKQH-NEELQ--ILVREQDD-QIKELK------ETKLTFEMNIPKTEGMI--IS 1115
K ++ + LQ + RE D ++ +L+ ++ L I E + +S
Sbjct: 996 HKAYENAVGILSRRLQEALAAREAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVS 1055
Query: 1116 STIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSV------LQEQSAKLNTELQ 1169
+ + + V ++ E+E + R L+E + KL EL+
Sbjct: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELE 1115
Query: 1170 ECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE-------LRS 1222
K+ L N L H+ + + + + ++ L QLN + +L E L
Sbjct: 1116 HEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQ 1175
Query: 1223 SISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYE-QLLDSVQSSTQE 1281
++ +++++ ++ L +Q A + H L E K E Q + + Q
Sbjct: 1176 ALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQA 1235
Query: 1282 ETNKIVTME-----QVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXX 1336
E + + E ++ Q +L + L+ LQ++ + +++ E+E+ K +
Sbjct: 1236 EADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPAGNQEMENLK--WEV 1293
Query: 1337 XXXXXXXXXXXXXXDLRTENQSYKQMQ--EQSILNINEE 1373
DL TE Q +K+++ +Q + N+ E
Sbjct: 1294 DQKEREIQSLKQQLDL-TEQQGWKELEGLQQLLQNVKSE 1331
Score = 77.8 bits (183), Expect = 3e-13
Identities = 159/987 (16%), Positives = 401/987 (40%), Gaps = 62/987 (6%)
Query: 632 ILQQKYDEVEDKLADIS---QLQSDQVCSEI--KSVHLEEQIDALSASKKELALV--IEN 684
+LQ E +D+ +++ + + D +CS + +S E Q + L K+++ L +E
Sbjct: 364 VLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEA 423
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ 744
L L+ Q +L+ + KLQ ++ + + + +S+E + L E+
Sbjct: 424 LSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSE-VDTLKQSCWDLER 482
Query: 745 SKIQTQFGIDAK---IQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQ 801
+ Q ++AK + + ++ E + + +++ ++ S+ ++ + L ++
Sbjct: 483 AMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTA 542
Query: 802 LGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEE 861
L S LQ+ Q + T + ++ L + ++QL + LQ + ++
Sbjct: 543 LQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE-MAHIQV 601
Query: 862 NQNLQISLSDMQQHYN-ALVEKANRTD-LAESESTKYQTQLRDLESNLKRITHEHQTLIV 919
Q Q L + + N +L ++ T + E + QL+ +E+++ + E + +
Sbjct: 602 GQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADM--LDQEAAFMQI 659
Query: 920 QKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVE 979
Q+ K + +E + ++E ++ E+ ++ + LE QL++ K + + +E
Sbjct: 660 QEAKTM--VEEDLQRRLEEFEGER----ERLQRMADSAASLEQQLEQVKLTLLQRDQQLE 713
Query: 980 ELNKMNLELIDKHVQKQQT-QSPDYTEQYIN-EINKLNALLKQKDEEIIALNQKINNAQV 1037
L + +L+L+ + Q+ QS + + + ++L A L + E + I Q
Sbjct: 714 ALQQEHLDLMKQLTLTQEALQSREQSLDALQTRYDELQARLGELQGEAASREDTICLLQN 773
Query: 1038 SYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKE 1097
+ + E+ L + E ++ +R+ + ++ + E+L+ + + Q++ L++
Sbjct: 774 EKIIL----EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQ 829
Query: 1098 TKLTFEMNIPKTEGMIISSTI--EPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERS 1155
+ + K + + + E DA + D L E +E QE
Sbjct: 830 ETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLD-SELKELRQELM 888
Query: 1156 VLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLS 1215
+ + EL + ++ Q+ +L GH Q++ +++++ L+ L + + +++
Sbjct: 889 QVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEVETHLQSLQFDKEQMVA 948
Query: 1216 TVAELRSSISSAVDQRGFEIAEL---WKQHLAQREADFQKTEHELRVQLSAFES------ 1266
V E ++ +++ E + KQ + + +D + E++ + A+E+
Sbjct: 949 -VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILS 1007
Query: 1267 -KYEQLLDSVQSSTQE----------ETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYAD 1315
+ ++ L + +++ E + + E++ +L+ +LQ H + L EK
Sbjct: 1008 RRLQEALAAREAADAELGQLRAQGGSSDSSLALHERIQALEAELQ-AVSHSKTLLEKELQ 1066
Query: 1316 VINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYK---QMQEQSILNINE 1372
+ + E EKV L N+ + ++ + + +
Sbjct: 1067 EVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQ 1126
Query: 1373 ENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLTQRND 1432
NA L++ + + +V + + E +D ++ +L + +
Sbjct: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKE 1186
Query: 1433 EFENVRQQLVEYEKRI-EDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLIE-- 1489
+ ++++Q+ + + + K + L + +K A + + ++E + +++ E
Sbjct: 1187 KVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGK 1246
Query: 1490 ---ELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNM 1546
E+ E Q+ L K L+E+++K +EN + E+ EI +L+
Sbjct: 1247 HSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPAGNQEMENLKWEVDQKEREIQSLKQQ 1306
Query: 1547 VRASSSKIQKHVSFASDTKQGRDEQLD 1573
+ + + K + Q +L+
Sbjct: 1307 LDLTEQQGWKELEGLQQLLQNVKSELE 1333
>DQ444714-1|ABE01857.1| 805|Homo sapiens cenexin 1 protein.
Length = 805
Score = 81.0 bits (191), Expect = 3e-14
Identities = 141/736 (19%), Positives = 318/736 (43%), Gaps = 94/736 (12%)
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
+L+D+S D K +++ID+L + L ++ K +++ +++ + +
Sbjct: 80 RLSDLSTEDDDS--GHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEE 137
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---- 758
E++ ++L EN L +E+M EK +L K + +++ + ++A++
Sbjct: 138 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 197
Query: 759 -ERDLYIENIESELSKYKSRICR-----------LEESIAVMEDRRYSL-----ERKADQ 801
++ + +++ +L K C L + ++ E+ +L E+ +
Sbjct: 198 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE 257
Query: 802 LGSYLQEKQKAYSEYTIQED-ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
L E+Q A + + D E L +L D D+ VE+ L EI+ E + + ++
Sbjct: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE---- 313
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L S+ M+ H A + E+E+++ Q++ NL+R ++H+ +
Sbjct: 314 ----LSKSMESMRGHLQAQLRS------KEAENSRLCMQIK----NLERSGNQHKAEVEA 359
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIEN 973
+++++L+ + + ES + + E+ EK+ EY QL QL E + +E+
Sbjct: 360 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 419
Query: 974 ----LNMNVEELNKMNLELI---DK---HVQKQQTQSPDYTEQYINEINKLN------AL 1017
N V+E + LE+I D+ V +QQT E + + +L+ +
Sbjct: 420 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 479
Query: 1018 LKQKDEEIIA----LNQKINNAQV----------SYMSMVSDYESKLAQFTTKLENMEEE 1063
K ++E + A + K+N A + +Y M+ +Y+S++ + + + + +
Sbjct: 480 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 539
Query: 1064 MQRVSKQ-LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
++R K+ + + N+E++ R+ Q+ +L++ ++ TE + +
Sbjct: 540 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKI----TEAKLAECQDQLQG 595
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+D ++ E +E+ Q+++ +L+ ++ E K+
Sbjct: 596 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ 655
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N E +E I+Q + +LE+ E L +L S+I A Q E K+
Sbjct: 656 NIEFLQVIAKREEAIHQSQLRLEEKTRECGTL---ARQLESAIEDARRQ-----VEQTKE 707
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQ 1300
H +E Q +L QLS +++ QL S + + +++ + +++ ++ +
Sbjct: 708 HALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 767
Query: 1301 DKEEHLRNLQEKYADV 1316
+ +++ L+ YA+V
Sbjct: 768 SMQNYVQFLKSSYANV 783
Score = 77.8 bits (183), Expect = 3e-13
Identities = 136/680 (20%), Positives = 291/680 (42%), Gaps = 66/680 (9%)
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
I R+ EE + L++EK L LV+ + M + K+++ +++ +LK
Sbjct: 159 IERMKEEKDFTILQKKHLQQEKECLMSKLVEAE---MDGAAAAKQVMALKDTIG-KLKTE 214
Query: 617 SLLESQKFD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+ + L ++ +L QK E+ + L +Q C E S L EQ AL
Sbjct: 215 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE-DSERLMEQQGAL---L 270
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
K LA +K +L ++D + + E+++ ++Q +K + +A ++S+
Sbjct: 271 KRLA----EADSEKARLLLLLQDKDKEVEELLQEIQ---------CEKAQAKTASELSKS 317
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
+ + Q++++++ +A+ + I+N+E +++K+ E A+ME + L
Sbjct: 318 MESMRGHLQAQLRSK---EAENSRLCMQIKNLERSGNQHKA------EVEAIMEQLK-EL 367
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV-LMDHDRVVEKQLLEIEHENKELQKK 854
++K D+ L++ +A E + +E +L V L D D V + L +E +
Sbjct: 368 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR---SRY 424
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
NQ+ ++E +L++ + +V TDL + T + D +S ++R+ H
Sbjct: 425 NQV-VKEKGDLELEI---------IVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-HRQ 473
Query: 915 QTLIVQKKKEIEDLEIEF---NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI 971
K E E L+ F ++ A + + L + + ++Q+ + +
Sbjct: 474 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 533
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ + +E +K N L D+ ++ + + Q + ++ +L +LK + ++ +
Sbjct: 534 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ-LADLQQLPDILKITEAKLAECQDQ 592
Query: 1032 INNAQ---VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ + + +++SD S++ KLE E+ Q S++ N++L + V E
Sbjct: 593 LQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA-------SQKENKQLSLKVDEL 645
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISS--TIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ +++ + F I K E I S +E + + + Q
Sbjct: 646 ERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQT 705
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+E + + Q + L T+L T++ QL + D Q ++ LK +LEQ
Sbjct: 706 KEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDA---DRRYQSRLQDLKDRLEQS 762
Query: 1207 NTENDNLLSTVAELRSSISS 1226
+ N ++ + V L+SS ++
Sbjct: 763 ESTNRSMQNYVQFLKSSYAN 782
Score = 46.8 bits (106), Expect = 6e-04
Identities = 86/451 (19%), Positives = 182/451 (40%), Gaps = 23/451 (5%)
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
ER + + + EL+E ++ + E NT L + +E+ + + + L E +
Sbjct: 123 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 182
Query: 1213 LLSTVAELRSSISSAVDQ---RGFEIAEL-WKQHLAQREADFQKTEHELRVQ-LSAFESK 1267
L+S + E ++A Q I +L ++ + + + + EL +Q LS FE
Sbjct: 183 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 242
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L D ++ +E ++ + MEQ +L +L + + L D ++E L EI
Sbjct: 243 NRTLRDLLREQHCKEDSERL-MEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 301
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN--EENAQLKKSSXXXX 1385
+ EK A L+ + +S + + + I E + K+
Sbjct: 302 QCEK-AQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 360
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK-THEYTITLTQRNDEFENVRQQLVEY 1444
+ D + + L+ + + + +E ++ + + L ++ L +
Sbjct: 361 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 420
Query: 1445 EKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
R + EK E E+ +L ++ + N +T++++ +R L+E L+ + E +
Sbjct: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+ N+ L+ A M+ L +E+ L + N + M+ S++ K
Sbjct: 481 KLE----NERLKASFA---PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK-TRLE 532
Query: 1562 SDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+D + E+ D NK L D + + E++ A
Sbjct: 533 ADEVAAQLERCDKE-NKILKDEMNK-EIEAA 561
Score = 42.3 bits (95), Expect = 0.014
Identities = 87/522 (16%), Positives = 193/522 (36%), Gaps = 27/522 (5%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
LE +EE++ V+ +L +++ N L R +++KE K+ + + ++ + + ++S
Sbjct: 131 LEERKEELEEVAHELAETEHENTVL----RHNIERMKEEKDFTILQKKHLQQEKECLMSK 186
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+E D A LK +++ ++ +++ L T
Sbjct: 187 LVEAEMDGAAAAKQVMALKDTIGK-LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRT 245
Query: 1177 QLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ L + D EQ L +L + ++E LL + + + + + E
Sbjct: 246 LRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEK 305
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQ 1291
A+ + ++ + L+ QL + E++ +L ++ S Q + MEQ
Sbjct: 306 AQA--KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQ 363
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L+ K +E L+ + + E ++ +
Sbjct: 364 LKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ-------LADKDLYVAEALST 416
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
L + Y Q+ ++ ++ E L ++ + ++E H+
Sbjct: 417 LESWRSRYNQVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 475
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
+ S + + D+ QQL K E + +S++ RL+ E
Sbjct: 476 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 535
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
A E KE++I + ++ +E+ + S + +L L+ AK E Q L+
Sbjct: 536 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 595
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKI----QKHVSFASDTKQ 1566
E + + L I++L++ + K+ +KH + + KQ
Sbjct: 596 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQ 637
>DQ444713-1|ABE01856.1| 824|Homo sapiens cenexin 1 variant 1 protein.
Length = 824
Score = 81.0 bits (191), Expect = 3e-14
Identities = 141/736 (19%), Positives = 318/736 (43%), Gaps = 94/736 (12%)
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
+L+D+S D K +++ID+L + L ++ K +++ +++ + +
Sbjct: 99 RLSDLSTEDDDS--GHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEE 156
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---- 758
E++ ++L EN L +E+M EK +L K + +++ + ++A++
Sbjct: 157 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 216
Query: 759 -ERDLYIENIESELSKYKSRICR-----------LEESIAVMEDRRYSL-----ERKADQ 801
++ + +++ +L K C L + ++ E+ +L E+ +
Sbjct: 217 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE 276
Query: 802 LGSYLQEKQKAYSEYTIQED-ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
L E+Q A + + D E L +L D D+ VE+ L EI+ E + + ++
Sbjct: 277 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE---- 332
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L S+ M+ H A + E+E+++ Q++ NL+R ++H+ +
Sbjct: 333 ----LSKSMESMRGHLQAQLRS------KEAENSRLCMQIK----NLERSGNQHKAEVEA 378
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIEN 973
+++++L+ + + ES + + E+ EK+ EY QL QL E + +E+
Sbjct: 379 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 438
Query: 974 ----LNMNVEELNKMNLELI---DK---HVQKQQTQSPDYTEQYINEINKLN------AL 1017
N V+E + LE+I D+ V +QQT E + + +L+ +
Sbjct: 439 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 498
Query: 1018 LKQKDEEIIA----LNQKINNAQV----------SYMSMVSDYESKLAQFTTKLENMEEE 1063
K ++E + A + K+N A + +Y M+ +Y+S++ + + + + +
Sbjct: 499 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 558
Query: 1064 MQRVSKQ-LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
++R K+ + + N+E++ R+ Q+ +L++ ++ TE + +
Sbjct: 559 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKI----TEAKLAECQDQLQG 614
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+D ++ E +E+ Q+++ +L+ ++ E K+
Sbjct: 615 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ 674
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N E +E I+Q + +LE+ E L +L S+I A Q E K+
Sbjct: 675 NIEFLQVIAKREEAIHQSQLRLEEKTRECGTL---ARQLESAIEDARRQ-----VEQTKE 726
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQ 1300
H +E Q +L QLS +++ QL S + + +++ + +++ ++ +
Sbjct: 727 HALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 786
Query: 1301 DKEEHLRNLQEKYADV 1316
+ +++ L+ YA+V
Sbjct: 787 SMQNYVQFLKSSYANV 802
Score = 77.8 bits (183), Expect = 3e-13
Identities = 136/680 (20%), Positives = 291/680 (42%), Gaps = 66/680 (9%)
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
I R+ EE + L++EK L LV+ + M + K+++ +++ +LK
Sbjct: 178 IERMKEEKDFTILQKKHLQQEKECLMSKLVEAE---MDGAAAAKQVMALKDTIG-KLKTE 233
Query: 617 SLLESQKFD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+ + L ++ +L QK E+ + L +Q C E S L EQ AL
Sbjct: 234 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE-DSERLMEQQGAL---L 289
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
K LA +K +L ++D + + E+++ ++Q +K + +A ++S+
Sbjct: 290 KRLA----EADSEKARLLLLLQDKDKEVEELLQEIQ---------CEKAQAKTASELSKS 336
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
+ + Q++++++ +A+ + I+N+E +++K+ E A+ME + L
Sbjct: 337 MESMRGHLQAQLRSK---EAENSRLCMQIKNLERSGNQHKA------EVEAIMEQLK-EL 386
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV-LMDHDRVVEKQLLEIEHENKELQKK 854
++K D+ L++ +A E + +E +L V L D D V + L +E +
Sbjct: 387 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR---SRY 443
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
NQ+ ++E +L++ + +V TDL + T + D +S ++R+ H
Sbjct: 444 NQV-VKEKGDLELEI---------IVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-HRQ 492
Query: 915 QTLIVQKKKEIEDLEIEF---NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI 971
K E E L+ F ++ A + + L + + ++Q+ + +
Sbjct: 493 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 552
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ + +E +K N L D+ ++ + + Q + ++ +L +LK + ++ +
Sbjct: 553 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ-LADLQQLPDILKITEAKLAECQDQ 611
Query: 1032 INNAQ---VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ + + +++SD S++ KLE E+ Q S++ N++L + V E
Sbjct: 612 LQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA-------SQKENKQLSLKVDEL 664
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISS--TIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ +++ + F I K E I S +E + + + Q
Sbjct: 665 ERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQT 724
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+E + + Q + L T+L T++ QL + D Q ++ LK +LEQ
Sbjct: 725 KEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDA---DRRYQSRLQDLKDRLEQS 781
Query: 1207 NTENDNLLSTVAELRSSISS 1226
+ N ++ + V L+SS ++
Sbjct: 782 ESTNRSMQNYVQFLKSSYAN 801
Score = 46.8 bits (106), Expect = 6e-04
Identities = 86/451 (19%), Positives = 182/451 (40%), Gaps = 23/451 (5%)
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
ER + + + EL+E ++ + E NT L + +E+ + + + L E +
Sbjct: 142 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 201
Query: 1213 LLSTVAELRSSISSAVDQ---RGFEIAEL-WKQHLAQREADFQKTEHELRVQ-LSAFESK 1267
L+S + E ++A Q I +L ++ + + + + EL +Q LS FE
Sbjct: 202 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 261
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L D ++ +E ++ + MEQ +L +L + + L D ++E L EI
Sbjct: 262 NRTLRDLLREQHCKEDSERL-MEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 320
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN--EENAQLKKSSXXXX 1385
+ EK A L+ + +S + + + I E + K+
Sbjct: 321 QCEK-AQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 379
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK-THEYTITLTQRNDEFENVRQQLVEY 1444
+ D + + L+ + + + +E ++ + + L ++ L +
Sbjct: 380 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 439
Query: 1445 EKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
R + EK E E+ +L ++ + N +T++++ +R L+E L+ + E +
Sbjct: 440 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 499
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+ N+ L+ A M+ L +E+ L + N + M+ S++ K
Sbjct: 500 KLE----NERLKASFA---PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK-TRLE 551
Query: 1562 SDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+D + E+ D NK L D + + E++ A
Sbjct: 552 ADEVAAQLERCDKE-NKILKDEMNK-EIEAA 580
Score = 42.3 bits (95), Expect = 0.014
Identities = 87/522 (16%), Positives = 193/522 (36%), Gaps = 27/522 (5%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
LE +EE++ V+ +L +++ N L R +++KE K+ + + ++ + + ++S
Sbjct: 150 LEERKEELEEVAHELAETEHENTVL----RHNIERMKEEKDFTILQKKHLQQEKECLMSK 205
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+E D A LK +++ ++ +++ L T
Sbjct: 206 LVEAEMDGAAAAKQVMALKDTIGK-LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRT 264
Query: 1177 QLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ L + D EQ L +L + ++E LL + + + + + E
Sbjct: 265 LRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEK 324
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQ 1291
A+ + ++ + L+ QL + E++ +L ++ S Q + MEQ
Sbjct: 325 AQA--KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQ 382
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L+ K +E L+ + + E ++ +
Sbjct: 383 LKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ-------LADKDLYVAEALST 435
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
L + Y Q+ ++ ++ E L ++ + ++E H+
Sbjct: 436 LESWRSRYNQVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 494
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
+ S + + D+ QQL K E + +S++ RL+ E
Sbjct: 495 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 554
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
A E KE++I + ++ +E+ + S + +L L+ AK E Q L+
Sbjct: 555 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 614
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKI----QKHVSFASDTKQ 1566
E + + L I++L++ + K+ +KH + + KQ
Sbjct: 615 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQ 656
>BC109126-1|AAI09127.1| 872|Homo sapiens chromosome 10 open reading
frame 80 protein.
Length = 872
Score = 81.0 bits (191), Expect = 3e-14
Identities = 132/689 (19%), Positives = 299/689 (43%), Gaps = 46/689 (6%)
Query: 673 ASKKELALVIENLKLDK--EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
A + LAL E + L K EQ G D ++ D++ + +E L ++ K+
Sbjct: 116 AKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLR-- 173
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
E LA+ ++Q +++ + I + I+ ++E S+ + +LE+ + ++
Sbjct: 174 ---ESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
Query: 791 RRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
S + + L Y+Q+ ++ E ++E +++N A + + +++ EN
Sbjct: 231 DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAA--KELEQFQMRNAKLQQEN 288
Query: 849 KELQKKNQILLEENQN--LQISLSDMQQHYNAL-VEKANRTDLAESESTKYQTQLRDLES 905
++ + L +ENQ L++ + + H L + K N+ + + T+ + E
Sbjct: 289 EQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKI-REQIHKKLHHTEDQKAEV 347
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ T ++Q + ++++ E + E + + ++ +R++ +LN+ K + TQ + L
Sbjct: 348 EQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVN-ATQKQTDL 406
Query: 965 ----QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ----TQSPDYTEQYI---NEINK 1013
++ K N+E N ++ + ++I H++K++ Q+ D T++ + +I
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDEAQKQRKII-FHLEKERDRYINQASDLTQKVLMNMEDIKV 465
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRVSKQ 1070
+ ++I K+ Q Y ++ SD Y L + ++ +M+ +++ + Q
Sbjct: 466 RETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQ 525
Query: 1071 LLDSKQH---NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
+ + K+ E + + + +I++ KET L E+ + + + IE +
Sbjct: 526 VDELKEDISAKESALVKLHLEQQRIEKEKET-LKAELQKLRQQALETKHFIEKQEAEERK 584
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELT 1186
+ K +E ++ I ER +L Q + N EL Y KI IQ LN
Sbjct: 585 LLRIIAEADGERLRQK-KELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLN---K 640
Query: 1187 GHDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
G NQ E + L+ ++++L E L ++A + + + E +
Sbjct: 641 GESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRAL 700
Query: 1245 QREADFQKTEHELRVQLSAFESKYE--QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+ E + H R ++ + YE Q + ++Q +T ++V E + + KL +
Sbjct: 701 EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYME 760
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+H+ ++ + Q+++ R + D+K
Sbjct: 761 LKHVL-ARQPGPEAAEQLKLYRRTLHDKK 788
Score = 78.2 bits (184), Expect = 2e-13
Identities = 133/651 (20%), Positives = 285/651 (43%), Gaps = 47/651 (7%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK-LKSAEEQITQLNDEIDAANKNMIKVKS 531
E + I++ Q++++Q N+ ++ K+ +EK LK + + EI A + + K K
Sbjct: 192 EAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKE 251
Query: 532 N-HKLK--LKQMQ-------KTIDNF----SKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
KL+ LK+ + K ++ F +K+ N++ + E+L +Q+ A LE +
Sbjct: 252 ELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKA-LELK 310
Query: 578 KGNLQLHLVDYDSGRM--IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
++H + D G++ I ++KK+ E+ + L++Q L +E+ +
Sbjct: 311 AKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEA-SK 369
Query: 636 KYDEVEDKLADISQLQSDQVCSE-IKSVHL-EEQIDALSA---SKKELALVIENLKLDKE 690
K E++ K D + D + +K+V+ ++Q D + +K+ L I+N K + +
Sbjct: 370 KQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQ 429
Query: 691 QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ 750
+ I LE +++ +N+ + Q+ + + + K+ +I + KI E Q Q
Sbjct: 430 KQRKIIFHLEKERDRYINQASDLTQKVLMNMEDI-KVRETQIFDYRKKIAESEIKLKQQQ 488
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQ 810
+A +R+LY +N+ + +L+ I +++ + + K L E+Q
Sbjct: 489 NLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQ 548
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQ------LLEI--EHENKELQKKNQI--LLE 860
+ E + EL ++ +EKQ LL I E + + L++K ++ ++
Sbjct: 549 RIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVIS 608
Query: 861 ENQNLQISLSDMQQHYNALVEKAN-RTDLAESESTKYQTQLRD---LESNLKRITHEHQT 916
E L L L EK + + ++Y +L D L +K++ E +
Sbjct: 609 ERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE-KG 667
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDK---KVLNEKYEK--NIEYVTQLEAQLQEYKNNI 971
++ + +E+L EF ++++ + L E+ E N+ +LEA I
Sbjct: 668 ILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ ++ + L E+++K + Q+ + +++ +Q L+ K
Sbjct: 728 QKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDK 787
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
+V S ++ YE + ++ ++E + E+Q + K+ L K+ E+LQ
Sbjct: 788 KQQLKV-LSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKR-KEQLQ 836
Score = 72.9 bits (171), Expect = 9e-12
Identities = 172/825 (20%), Positives = 359/825 (43%), Gaps = 94/825 (11%)
Query: 471 NTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL-----------KSAEEQITQLNDEI 519
N E V AKV LK +D+ ++K IEK + A+E I L +EI
Sbjct: 68 NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
Query: 520 DAANKNMIK---VKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAELE 575
K + + + + ++ + + + +K D E+V+L E L +++ E E
Sbjct: 128 VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
Query: 576 EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL-LESQKFDLVQELHILQ 634
K + + + + + + E LK I ++S++ E+ LQ
Sbjct: 188 RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQ----TEIKALQ 243
Query: 635 QKYDEVEDKLADI-SQLQSDQVCSEIKSVHLEE---QIDALSASKKELALVIENLKLDKE 690
Q + +++L + QL+ ++ +E + LE+ + L ++ +LV E L + +
Sbjct: 244 QYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQ 303
Query: 691 QLYGTIKDLEND----KEDI--MNKLQNYIQENMDLTD--KLE-KMSAEKISELLAKINH 741
Q +K E + + DI +NK++ I + + T+ K E + E + + +
Sbjct: 304 QKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLER 363
Query: 742 E-EQSKIQTQF---GIDAKIQERDLYIENIESEL--SKYKSRICRL-EESIAVMEDRRYS 794
E E SK Q + +D ++ERD+ +N+ + ++ ++ + +L E++ +E +
Sbjct: 364 EVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQN 423
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
+ +A + + +K Y Q +L ++ + M+ +V E Q+ + + E
Sbjct: 424 YKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE---- 479
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
++I L++ QNL Y A+ +++R +L + Q ++ D++ LK + H+
Sbjct: 480 SEIKLKQQQNL----------YEAV--RSDR-NLYSKNLVEAQDEITDMKRKLKIMIHQ- 525
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
V + K ED+ + + ++ + +++ EK E + +L Q E K+ IE
Sbjct: 526 ----VDELK--EDISAKESALVKLHLEQQRIEKEKETLKAE-LQKLRQQALETKHFIEK- 577
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+E + L I ++ + +Q I+E + L + L ++++E+ L +KI
Sbjct: 578 ----QEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKI 633
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
Q S+++ ES Q+ +LE+M R+ + L+ K+ E IL R + ++E
Sbjct: 634 QQ----SVLNKGES---QYNQRLEDM-----RILR--LEIKKLRREKGILARSMAN-VEE 678
Query: 1095 LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
L++ F M + +E ++ NV ++ ++ +Q+R
Sbjct: 679 LRQE--FFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKR 736
Query: 1155 SVLQ-EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQI--NQLKSKLEQLNTEND 1211
+ + E+ + LQE ++L+ + G + Q ++ L K +QL +
Sbjct: 737 LISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSS 796
Query: 1212 NLLSTVAELRS-SISSAVDQRGFEIAELWKQHLAQ-READFQKTE 1254
L + E++S V++ E+ L K++LAQ R+ QK +
Sbjct: 797 EL--NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
Score = 60.5 bits (140), Expect = 5e-08
Identities = 133/660 (20%), Positives = 287/660 (43%), Gaps = 84/660 (12%)
Query: 306 EKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK 365
+K ++E++ A+M +I+ L+ Q Q +KE KL E K ++ + K
Sbjct: 217 KKEKLEKELKQIQADMDSRQTEIKALQ----QYVQKSKEELQKLEQQLKEQKILNERAAK 272
Query: 366 GSPLISRKSGRNTASKMKSPW--SQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVD 423
++ + + QLS E + + K + E+ ++ + I LNK
Sbjct: 273 ELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNK---I 329
Query: 424 KEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQE 483
+E + + K+TL Q+ VG E E +K Q
Sbjct: 330 REQIHKKLHHTEDQKAEVEQHKETLKNQI---------------VGLERE--VEASKKQA 372
Query: 484 QLKQELNDEI---KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
+L ++ DE+ +D+ K++++ + + ++Q T L + A +N+ N+K + ++
Sbjct: 373 ELDRKAMDELLRERDILNKNMLKAVNATQKQ-TDLVKLHEQAKRNLEGEIQNYKDEAQKQ 431
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYK 600
+K I + K D R + L+QKV E+ + + DY ++ ES++
Sbjct: 432 RKIIFHLEKERD------RYINQASDLTQKVLMNMEDIKVRETQIFDYRK-KIAESEI-- 482
Query: 601 KMIEMENLAET-----RLKAISLLESQK--FDLVQELHILQQKYDEVEDKLADISQLQSD 653
K+ + +NL E L + +L+E+Q D+ ++L I+ + DE+++ DIS +S
Sbjct: 483 KLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE---DISAKESA 539
Query: 654 QVCSEIKSVHLEEQIDALSASKKEL---AL----VIENLKLDKEQLYGTIKDLENDKEDI 706
V ++ +E++ + L A ++L AL IE + ++ +L I + + ++
Sbjct: 540 LVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQ 599
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
+L I E L +L + + ++++ L KI ++ + + + +++ D+ I
Sbjct: 600 KKELDQVISERDILGSQLVRRN-DELALLYEKIKIQQSVLNKGESQYNQRLE--DMRILR 656
Query: 767 IE-SELSKYKSRICRLEESIAVMEDRRYSLER-------KADQLGSYLQEKQKAYSEYTI 818
+E +L + K + R ++ + + ++R + L L+ + +
Sbjct: 657 LEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKL 716
Query: 819 QED-----ELVNRLAVLMDH-----DRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ EL+ ++ L + VVEK+LL E E ++ K+ + + +
Sbjct: 717 EASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPE---A 773
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL----IVQKKKE 924
++ + L +K + + SE Y+ Q ++ + ++++T+E Q L + QK+KE
Sbjct: 774 AEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
Score = 59.7 bits (138), Expect = 9e-08
Identities = 71/398 (17%), Positives = 164/398 (41%), Gaps = 26/398 (6%)
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRG 1232
+I+ L L + +G + I L E++ E D LLS V +LR S++ + Q+
Sbjct: 126 EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
Query: 1233 FEIAELWKQH-LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ 1291
E ++ +H ++Q + + Q+ ++E + E K E+ L +Q+ +I ++Q
Sbjct: 186 TERSKEEAEHAISQFQQEIQQRQNEASREFRKKE-KLEKELKQIQADMDSRQTEIKALQQ 244
Query: 1292 -VTSLQNKLQDKEEHLRN---LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
V + +LQ E+ L+ L E+ A + Q ++ ++++ E
Sbjct: 245 YVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQ 304
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
+L+ + + QM+ I +N+ Q+ K + +++ L
Sbjct: 305 KALELKAKEEEVHQMR-LDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLER 363
Query: 1408 QLE----------------LKDSEIYQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIED 1450
++E L++ +I K + TQ+ + + +Q E I++
Sbjct: 364 EVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQN 423
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNK 1510
E + + I+ + + + Y + + + +E++ V+ T+ K++AE
Sbjct: 424 YKDEAQKQRKII-FHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEI 482
Query: 1511 ALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
L+++ +++ +V DEIT+++ ++
Sbjct: 483 KLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLK 520
Score = 54.4 bits (125), Expect = 3e-06
Identities = 94/592 (15%), Positives = 243/592 (41%), Gaps = 43/592 (7%)
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNA-QVSY--MSMVSDYESKLAQFTTKLENME 1061
+ Y NE +L A ++ + EI+ + K+ A ++S + ++ + ++ + +++
Sbjct: 52 KSYDNE-KRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAY 110
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQD----DQIKELKETKLTFEMNIPKTEGMIISST 1117
++ Q+ + +L K+ L LV + DQ +++ L F+ + K ++S
Sbjct: 111 DKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL-LRFKEEVTKERDQLLSEV 169
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQERS--VLQE--QSAKLNTELQECY 1172
++ A + + + ++ IQ+R +E + KL EL++
Sbjct: 170 VKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQ 229
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE--LRSSISSAVDQ 1230
+ +T L + ++E++ +L+ +L++ N+ + + +R++ ++
Sbjct: 230 ADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENE 289
Query: 1231 RGFEIAELWKQHLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQSSTQE----ET 1283
+ + E Q Q+ + + E H++R+ + EQ+ + + + E
Sbjct: 290 QHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQ 349
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXX 1343
+K Q+ L+ +++ ++ ++ +++ + +IL + + V
Sbjct: 350 HKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNML-KAVNATQKQTDLVK 408
Query: 1344 XXXXXXXDLRTENQSYK---QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
+L E Q+YK Q Q + I ++ +E + + + E
Sbjct: 409 LHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRET 468
Query: 1401 KVLELTHQLELKDSEIYQKTHEYTITLTQRN----------DEFENVRQQLVEYEKRIED 1450
++ + ++ + ++ Q+ + Y + RN DE +++++L ++++
Sbjct: 469 QIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE 528
Query: 1451 LTYE---KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
L + KES L L L+ ET++ E + R + +E + + K +
Sbjct: 529 LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRI 588
Query: 1508 LNKALEEEVAKTNEMQTALENQEI---EIVTLNDEITNLQNMVRASSSKIQK 1556
+ +A E + + E+ + ++I ++V NDE+ L ++ S + K
Sbjct: 589 IAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNK 640
Score = 52.8 bits (121), Expect = 1e-05
Identities = 133/776 (17%), Positives = 308/776 (39%), Gaps = 59/776 (7%)
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLS 870
K+ ++ I+ + L + D+++ + + E+ E K L+ +Q+ Q +++
Sbjct: 34 KSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIA 93
Query: 871 DMQQHYNALVEKA-NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+++ +EKA D A + K + + L+ + +T L+ Q L
Sbjct: 94 SLKKE----IEKAWKMVDSAYDKEQKAKETILALKEEIVNLTK----LVEQGS----GLS 141
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
++ ++ I +R K+ + ++ ++ + V +L L + + + EE +
Sbjct: 142 MDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQ 201
Query: 990 DKHVQKQQTQSPDYT--EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
+ Q+Q S ++ E+ E+ ++ A + + EI AL Q + ++ + +
Sbjct: 202 QEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLK 261
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK---ETKLTFEM 1104
+ + +E+ R +K +++QH+ + L +E + ELK E +
Sbjct: 262 EQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRL 321
Query: 1105 NIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE-------------EE 1149
+I K + I + D V+ L+ + E +E
Sbjct: 322 DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDE 381
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQL-ETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
++ER +L + K Q+ T +++L E L G +++ + + + L
Sbjct: 382 LLRERDILNKNMLKAVNATQK-QTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEK 440
Query: 1209 ENDNLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFES 1266
E D ++ ++L + ++ ++ +++ +A+ E K + L + + +
Sbjct: 441 ERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL-KQQQNLYEAVRSDRN 499
Query: 1267 KYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
Y + L Q + K+ + + QV L+ + KE L L + + + E L++
Sbjct: 500 LYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKA 559
Query: 1326 EIED------EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
E++ E F + E K+ +Q I + +QL +
Sbjct: 560 ELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVR 619
Query: 1380 SSXXXXXXXXXXXXR---VNDAEAKVLELTHQLELKDSEIYQKTHEYTI------TLTQR 1430
+ + +N E++ + + + EI + E I + +
Sbjct: 620 RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEEL 679
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE--NANHYETMQKESEIERVKLI 1488
EF +++++L++ R L E E+ L + R + E + N YE +QK +++ +LI
Sbjct: 680 RQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQK-RLI 738
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+ ++ E L ++ +L L+ +A+ + A E ++ TL+D+ L+
Sbjct: 739 SKTE-EVVEKELLLQEKEKLYMELKHVLARQPGPEAA-EQLKLYRRTLHDKKQQLK 792
Score = 49.2 bits (112), Expect = 1e-04
Identities = 81/460 (17%), Positives = 188/460 (40%), Gaps = 39/460 (8%)
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+EE +ER L + KL L + T Q ET ++ ++Q Q +++ + +
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQ--TTEQQQETERSKEEAEHAISQFQ-QEIQQRQNEA 211
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
+ E EL+ I + +D R EI L +Q++ + + + QK E +L+ Q E
Sbjct: 212 SREFRKKEKLEKELKQ-IQADMDSRQTEIKAL-QQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 1267 KYEQL----LDSVQSSTQEETNKIVTME-----QVTSLQNKLQDKEEH--------LRNL 1309
++L + + + + E + +V + Q +L+ K +++E H L +
Sbjct: 270 AAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKI 329
Query: 1310 QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM-QEQSIL 1368
+E+ ++ E ++E+E K + ++ ++ +E+ IL
Sbjct: 330 REQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDIL 389
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
N N A R + E ++ + + + I+ E +
Sbjct: 390 NKNMLKAVNATQKQTDLVKLHEQAKR--NLEGEIQNYKDEAQKQRKIIFHLEKERDRYIN 447
Query: 1429 QRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLI 1488
Q +D + V + + + R E ++ ++A +K+ + N YE ++ + + L+
Sbjct: 448 QASDLTQKVLMNMEDIKVR-ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLV 506
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
E + ++ ++ + L+ + + +E++ + +E +V L+ E ++
Sbjct: 507 EAQD-----------EITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKE 555
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAE 1588
+++QK A +TK ++Q ++LL + A+
Sbjct: 556 TLKAELQKLRQQALETKHFIEKQ--EAEERKLLRIIAEAD 593
Score = 40.7 bits (91), Expect = 0.042
Identities = 58/321 (18%), Positives = 128/321 (39%), Gaps = 19/321 (5%)
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
D + + E+ + S+ +L +S+ +T+++ + E+ ++ + ++ ++
Sbjct: 150 DLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEA---EHAISQFQQEIQQ 206
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
Q + + + E L E++ + + +Q++EQ IL
Sbjct: 207 RQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKIL 266
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQ---LELKDSEIYQKTHEYTI 1425
N E A + + + L +Q LELK E ++ H+ +
Sbjct: 267 N---ERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKE--EEVHQMRL 321
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERV 1485
+ + N +R+Q+ + ED E E L+ ++ E +K++E++R
Sbjct: 322 DIGKLN----KIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDR- 376
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
K ++EL + E LNK + + A +++ + A N E EI DE +
Sbjct: 377 KAMDEL---LRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
Query: 1546 MVRASSSKIQKHVSFASDTKQ 1566
++ + ++++ ASD Q
Sbjct: 434 IIFHLEKERDRYINQASDLTQ 454
>BC091500-1|AAH91500.1| 829|Homo sapiens ODF2 protein protein.
Length = 829
Score = 81.0 bits (191), Expect = 3e-14
Identities = 141/736 (19%), Positives = 318/736 (43%), Gaps = 94/736 (12%)
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
+L+D+S D K +++ID+L + L ++ K +++ +++ + +
Sbjct: 104 RLSDLSTEDDDS--GHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEE 161
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---- 758
E++ ++L EN L +E+M EK +L K + +++ + ++A++
Sbjct: 162 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 221
Query: 759 -ERDLYIENIESELSKYKSRICR-----------LEESIAVMEDRRYSL-----ERKADQ 801
++ + +++ +L K C L + ++ E+ +L E+ +
Sbjct: 222 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE 281
Query: 802 LGSYLQEKQKAYSEYTIQED-ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
L E+Q A + + D E L +L D D+ VE+ L EI+ E + + ++
Sbjct: 282 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE---- 337
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L S+ M+ H A + E+E+++ Q++ NL+R ++H+ +
Sbjct: 338 ----LSKSMESMRGHLQAQLRS------KEAENSRLCMQIK----NLERSGNQHKAEVEA 383
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIEN 973
+++++L+ + + ES + + E+ EK+ EY QL QL E + +E+
Sbjct: 384 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 443
Query: 974 ----LNMNVEELNKMNLELI---DK---HVQKQQTQSPDYTEQYINEINKLN------AL 1017
N V+E + LE+I D+ V +QQT E + + +L+ +
Sbjct: 444 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 503
Query: 1018 LKQKDEEIIA----LNQKINNAQV----------SYMSMVSDYESKLAQFTTKLENMEEE 1063
K ++E + A + K+N A + +Y M+ +Y+S++ + + + + +
Sbjct: 504 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 563
Query: 1064 MQRVSKQ-LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
++R K+ + + N+E++ R+ Q+ +L++ ++ TE + +
Sbjct: 564 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKI----TEAKLAECQDQLQG 619
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+D ++ E +E+ Q+++ +L+ ++ E K+
Sbjct: 620 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ 679
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N E +E I+Q + +LE+ E L +L S+I A Q E K+
Sbjct: 680 NIEFLQVIAKREEAIHQSQLRLEEKTRECGTL---ARQLESAIEDARRQ-----VEQTKE 731
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQ 1300
H +E Q +L QLS +++ QL S + + +++ + +++ ++ +
Sbjct: 732 HALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 791
Query: 1301 DKEEHLRNLQEKYADV 1316
+ +++ L+ YA+V
Sbjct: 792 SMQNYVQFLKSSYANV 807
Score = 77.8 bits (183), Expect = 3e-13
Identities = 136/680 (20%), Positives = 291/680 (42%), Gaps = 66/680 (9%)
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
I R+ EE + L++EK L LV+ + M + K+++ +++ +LK
Sbjct: 183 IERMKEEKDFTILQKKHLQQEKECLMSKLVEAE---MDGAAAAKQVMALKDTIG-KLKTE 238
Query: 617 SLLESQKFD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+ + L ++ +L QK E+ + L +Q C E S L EQ AL
Sbjct: 239 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE-DSERLMEQQGAL---L 294
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
K LA +K +L ++D + + E+++ ++Q +K + +A ++S+
Sbjct: 295 KRLA----EADSEKARLLLLLQDKDKEVEELLQEIQ---------CEKAQAKTASELSKS 341
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
+ + Q++++++ +A+ + I+N+E +++K+ E A+ME + L
Sbjct: 342 MESMRGHLQAQLRSK---EAENSRLCMQIKNLERSGNQHKA------EVEAIMEQLK-EL 391
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV-LMDHDRVVEKQLLEIEHENKELQKK 854
++K D+ L++ +A E + +E +L V L D D V + L +E +
Sbjct: 392 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR---SRY 448
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
NQ+ ++E +L++ + +V TDL + T + D +S ++R+ H
Sbjct: 449 NQV-VKEKGDLELEI---------IVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-HRQ 497
Query: 915 QTLIVQKKKEIEDLEIEF---NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI 971
K E E L+ F ++ A + + L + + ++Q+ + +
Sbjct: 498 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 557
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ + +E +K N L D+ ++ + + Q + ++ +L +LK + ++ +
Sbjct: 558 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ-LADLQQLPDILKITEAKLAECQDQ 616
Query: 1032 INNAQ---VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ + + +++SD S++ KLE E+ Q S++ N++L + V E
Sbjct: 617 LQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA-------SQKENKQLSLKVDEL 669
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISS--TIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ +++ + F I K E I S +E + + + Q
Sbjct: 670 ERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQT 729
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+E + + Q + L T+L T++ QL + D Q ++ LK +LEQ
Sbjct: 730 KEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDA---DRRYQSRLQDLKDRLEQS 786
Query: 1207 NTENDNLLSTVAELRSSISS 1226
+ N ++ + V L+SS ++
Sbjct: 787 ESTNRSMQNYVQFLKSSYAN 806
Score = 46.8 bits (106), Expect = 6e-04
Identities = 86/451 (19%), Positives = 182/451 (40%), Gaps = 23/451 (5%)
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
ER + + + EL+E ++ + E NT L + +E+ + + + L E +
Sbjct: 147 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 206
Query: 1213 LLSTVAELRSSISSAVDQ---RGFEIAEL-WKQHLAQREADFQKTEHELRVQ-LSAFESK 1267
L+S + E ++A Q I +L ++ + + + + EL +Q LS FE
Sbjct: 207 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 266
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L D ++ +E ++ + MEQ +L +L + + L D ++E L EI
Sbjct: 267 NRTLRDLLREQHCKEDSERL-MEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 325
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN--EENAQLKKSSXXXX 1385
+ EK A L+ + +S + + + I E + K+
Sbjct: 326 QCEK-AQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 384
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK-THEYTITLTQRNDEFENVRQQLVEY 1444
+ D + + L+ + + + +E ++ + + L ++ L +
Sbjct: 385 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 444
Query: 1445 EKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
R + EK E E+ +L ++ + N +T++++ +R L+E L+ + E +
Sbjct: 445 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 504
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+ N+ L+ A M+ L +E+ L + N + M+ S++ K
Sbjct: 505 KLE----NERLKASFA---PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK-TRLE 556
Query: 1562 SDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+D + E+ D NK L D + + E++ A
Sbjct: 557 ADEVAAQLERCDKE-NKILKDEMNK-EIEAA 585
Score = 42.3 bits (95), Expect = 0.014
Identities = 87/522 (16%), Positives = 193/522 (36%), Gaps = 27/522 (5%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
LE +EE++ V+ +L +++ N L R +++KE K+ + + ++ + + ++S
Sbjct: 155 LEERKEELEEVAHELAETEHENTVL----RHNIERMKEEKDFTILQKKHLQQEKECLMSK 210
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+E D A LK +++ ++ +++ L T
Sbjct: 211 LVEAEMDGAAAAKQVMALKDTIGK-LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRT 269
Query: 1177 QLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ L + D EQ L +L + ++E LL + + + + + E
Sbjct: 270 LRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEK 329
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQ 1291
A+ + ++ + L+ QL + E++ +L ++ S Q + MEQ
Sbjct: 330 AQA--KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQ 387
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L+ K +E L+ + + E ++ +
Sbjct: 388 LKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ-------LADKDLYVAEALST 440
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
L + Y Q+ ++ ++ E L ++ + ++E H+
Sbjct: 441 LESWRSRYNQVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 499
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
+ S + + D+ QQL K E + +S++ RL+ E
Sbjct: 500 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 559
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
A E KE++I + ++ +E+ + S + +L L+ AK E Q L+
Sbjct: 560 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 619
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKI----QKHVSFASDTKQ 1566
E + + L I++L++ + K+ +KH + + KQ
Sbjct: 620 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQ 661
>BC036225-1|AAH36225.1| 872|Homo sapiens chromosome 10 open reading
frame 80 protein.
Length = 872
Score = 81.0 bits (191), Expect = 3e-14
Identities = 132/689 (19%), Positives = 299/689 (43%), Gaps = 46/689 (6%)
Query: 673 ASKKELALVIENLKLDK--EQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAE 730
A + LAL E + L K EQ G D ++ D++ + +E L ++ K+
Sbjct: 116 AKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLR-- 173
Query: 731 KISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMED 790
E LA+ ++Q +++ + I + I+ ++E S+ + +LE+ + ++
Sbjct: 174 ---ESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
Query: 791 RRYSLERKADQLGSYLQEKQKAYS--EYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHEN 848
S + + L Y+Q+ ++ E ++E +++N A + + +++ EN
Sbjct: 231 DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAA--KELEQFQMRNAKLQQEN 288
Query: 849 KELQKKNQILLEENQN--LQISLSDMQQHYNAL-VEKANRTDLAESESTKYQTQLRDLES 905
++ + L +ENQ L++ + + H L + K N+ + + T+ + E
Sbjct: 289 EQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKI-REQIHKKLHHTEDQKAEV 347
Query: 906 NLKRITHEHQTLIVQKKKEIEDLEIEFNTQ-IESAIRDKKVLNEKYEKNIEYVTQLEAQL 964
+ T ++Q + ++++ E + E + + ++ +R++ +LN+ K + TQ + L
Sbjct: 348 EQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVN-ATQKQTDL 406
Query: 965 ----QEYKNNIENLNMNVEELNKMNLELIDKHVQKQQ----TQSPDYTEQYI---NEINK 1013
++ K N+E N ++ + ++I H++K++ Q+ D T++ + +I
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDEAQKQRKII-FHLEKERDRYINQASDLTQKVLMNMEDIKV 465
Query: 1014 LNALLKQKDEEIIALNQKINNAQVSYMSMVSD---YESKLAQFTTKLENMEEEMQRVSKQ 1070
+ ++I K+ Q Y ++ SD Y L + ++ +M+ +++ + Q
Sbjct: 466 RETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQ 525
Query: 1071 LLDSKQH---NEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANN 1127
+ + K+ E + + + +I++ KET L E+ + + + IE +
Sbjct: 526 VDELKEDISAKESALVKLHLEQQRIEKEKET-LKAELQKLRQQALETKHFIEKQEAEERK 584
Query: 1128 VDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKI-IQLETLNTELT 1186
+ K +E ++ I ER +L Q + N EL Y KI IQ LN
Sbjct: 585 LLRIIAEADGERLRQK-KELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLN---K 640
Query: 1187 GHDVVNQ--EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLA 1244
G NQ E + L+ ++++L E L ++A + + + E +
Sbjct: 641 GESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRAL 700
Query: 1245 QREADFQKTEHELRVQLSAFESKYE--QLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDK 1302
+ E + H R ++ + YE Q + ++Q +T ++V E + + KL +
Sbjct: 701 EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYME 760
Query: 1303 EEHLRNLQEKYADVINQIEILRSEIEDEK 1331
+H+ ++ + Q+++ R + D+K
Sbjct: 761 LKHVL-ARQPGPEAAEQLKLYRRTLHDKK 788
Score = 78.2 bits (184), Expect = 2e-13
Identities = 133/651 (20%), Positives = 285/651 (43%), Gaps = 47/651 (7%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEK-LKSAEEQITQLNDEIDAANKNMIKVKS 531
E + I++ Q++++Q N+ ++ K+ +EK LK + + EI A + + K K
Sbjct: 192 EAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKE 251
Query: 532 N-HKLK--LKQMQ-------KTIDNF----SKVSDSNKEIVRLTEELHHLSQKVAELEEE 577
KL+ LK+ + K ++ F +K+ N++ + E+L +Q+ A LE +
Sbjct: 252 ELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKA-LELK 310
Query: 578 KGNLQLHLVDYDSGRM--IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQ 635
++H + D G++ I ++KK+ E+ + L++Q L +E+ +
Sbjct: 311 AKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEA-SK 369
Query: 636 KYDEVEDKLADISQLQSDQVCSE-IKSVHL-EEQIDALSA---SKKELALVIENLKLDKE 690
K E++ K D + D + +K+V+ ++Q D + +K+ L I+N K + +
Sbjct: 370 KQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQ 429
Query: 691 QLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQ 750
+ I LE +++ +N+ + Q+ + + + K+ +I + KI E Q Q
Sbjct: 430 KQRKIIFHLEKERDRYINQASDLTQKVLMNMEDI-KVRETQIFDYRKKIAESEIKLKQQQ 488
Query: 751 FGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQ 810
+A +R+LY +N+ + +L+ I +++ + + K L E+Q
Sbjct: 489 NLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQ 548
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQ------LLEI--EHENKELQKKNQI--LLE 860
+ E + EL ++ +EKQ LL I E + + L++K ++ ++
Sbjct: 549 RIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVIS 608
Query: 861 ENQNLQISLSDMQQHYNALVEKAN-RTDLAESESTKYQTQLRD---LESNLKRITHEHQT 916
E L L L EK + + ++Y +L D L +K++ E +
Sbjct: 609 ERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE-KG 667
Query: 917 LIVQKKKEIEDLEIEFNTQIESAIRDK---KVLNEKYEK--NIEYVTQLEAQLQEYKNNI 971
++ + +E+L EF ++++ + L E+ E N+ +LEA I
Sbjct: 668 ILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ ++ + L E+++K + Q+ + +++ +Q L+ K
Sbjct: 728 QKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDK 787
Query: 1032 INNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQ 1082
+V S ++ YE + ++ ++E + E+Q + K+ L K+ E+LQ
Sbjct: 788 KQQLKV-LSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKR-KEQLQ 836
Score = 72.9 bits (171), Expect = 9e-12
Identities = 172/825 (20%), Positives = 359/825 (43%), Gaps = 94/825 (11%)
Query: 471 NTEDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKL-----------KSAEEQITQLNDEI 519
N E V AKV LK +D+ ++K IEK + A+E I L +EI
Sbjct: 68 NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
Query: 520 DAANKNMIK---VKSNHKLKLKQMQKTIDNFSKVSDS-NKEIVRLTEELHHLSQKVAELE 575
K + + + + ++ + + + +K D E+V+L E L +++ E E
Sbjct: 128 VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
Query: 576 EEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISL-LESQKFDLVQELHILQ 634
K + + + + + + E LK I ++S++ E+ LQ
Sbjct: 188 RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQ----TEIKALQ 243
Query: 635 QKYDEVEDKLADI-SQLQSDQVCSEIKSVHLEE---QIDALSASKKELALVIENLKLDKE 690
Q + +++L + QL+ ++ +E + LE+ + L ++ +LV E L + +
Sbjct: 244 QYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQ 303
Query: 691 QLYGTIKDLEND----KEDI--MNKLQNYIQENMDLTD--KLE-KMSAEKISELLAKINH 741
Q +K E + + DI +NK++ I + + T+ K E + E + + +
Sbjct: 304 QKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLER 363
Query: 742 E-EQSKIQTQF---GIDAKIQERDLYIENIESEL--SKYKSRICRL-EESIAVMEDRRYS 794
E E SK Q + +D ++ERD+ +N+ + ++ ++ + +L E++ +E +
Sbjct: 364 EVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQN 423
Query: 795 LERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKK 854
+ +A + + +K Y Q +L ++ + M+ +V E Q+ + + E
Sbjct: 424 YKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE---- 479
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
++I L++ QNL Y A+ +++R +L + Q ++ D++ LK + H+
Sbjct: 480 SEIKLKQQQNL----------YEAV--RSDR-NLYSKNLVEAQDEITDMKRKLKIMIHQ- 525
Query: 915 QTLIVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL 974
V + K ED+ + + ++ + +++ EK E + +L Q E K+ IE
Sbjct: 526 ----VDELK--EDISAKESALVKLHLEQQRIEKEKETLKAE-LQKLRQQALETKHFIEK- 577
Query: 975 NMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINN 1034
+E + L I ++ + +Q I+E + L + L ++++E+ L +KI
Sbjct: 578 ----QEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKI 633
Query: 1035 AQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKE 1094
Q S+++ ES Q+ +LE+M R+ + L+ K+ E IL R + ++E
Sbjct: 634 QQ----SVLNKGES---QYNQRLEDM-----RILR--LEIKKLRREKGILARSMAN-VEE 678
Query: 1095 LKETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER 1154
L++ F M + +E ++ NV ++ ++ +Q+R
Sbjct: 679 LRQE--FFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKR 736
Query: 1155 SVLQ-EQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQI--NQLKSKLEQLNTEND 1211
+ + E+ + LQE ++L+ + G + Q ++ L K +QL +
Sbjct: 737 LISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSS 796
Query: 1212 NLLSTVAELRS-SISSAVDQRGFEIAELWKQHLAQ-READFQKTE 1254
L + E++S V++ E+ L K++LAQ R+ QK +
Sbjct: 797 EL--NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
Score = 60.5 bits (140), Expect = 5e-08
Identities = 133/660 (20%), Positives = 287/660 (43%), Gaps = 84/660 (12%)
Query: 306 EKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGTESKAVSSPSKK 365
+K ++E++ A+M +I+ L+ Q Q +KE KL E K ++ + K
Sbjct: 217 KKEKLEKELKQIQADMDSRQTEIKALQ----QYVQKSKEELQKLEQQLKEQKILNERAAK 272
Query: 366 GSPLISRKSGRNTASKMKSPW--SQLSSETLNQDTDKKINKNEIAKLEMVIQSLNKDLVD 423
++ + + QLS E + + K + E+ ++ + I LNK
Sbjct: 273 ELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNK---I 329
Query: 424 KEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNEIAKVQE 483
+E + + K+TL Q+ VG E E +K Q
Sbjct: 330 REQIHKKLHHTEDQKAEVEQHKETLKNQI---------------VGLERE--VEASKKQA 372
Query: 484 QLKQELNDEI---KDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQM 540
+L ++ DE+ +D+ K++++ + + ++Q T L + A +N+ N+K + ++
Sbjct: 373 ELDRKAMDELLRERDILNKNMLKAVNATQKQ-TDLVKLHEQAKRNLEGEIQNYKDEAQKQ 431
Query: 541 QKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYK 600
+K I + K D R + L+QKV E+ + + DY ++ ES++
Sbjct: 432 RKIIFHLEKERD------RYINQASDLTQKVLMNMEDIKVRETQIFDYRK-KIAESEI-- 482
Query: 601 KMIEMENLAET-----RLKAISLLESQK--FDLVQELHILQQKYDEVEDKLADISQLQSD 653
K+ + +NL E L + +L+E+Q D+ ++L I+ + DE+++ DIS +S
Sbjct: 483 KLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE---DISAKESA 539
Query: 654 QVCSEIKSVHLEEQIDALSASKKEL---AL----VIENLKLDKEQLYGTIKDLENDKEDI 706
V ++ +E++ + L A ++L AL IE + ++ +L I + + ++
Sbjct: 540 LVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQ 599
Query: 707 MNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIEN 766
+L I E L +L + + ++++ L KI ++ + + + +++ D+ I
Sbjct: 600 KKELDQVISERDILGSQLVRRN-DELALLYEKIKIQQSVLNKGESQYNQRLE--DMRILR 656
Query: 767 IE-SELSKYKSRICRLEESIAVMEDRRYSLER-------KADQLGSYLQEKQKAYSEYTI 818
+E +L + K + R ++ + + ++R + L L+ + +
Sbjct: 657 LEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKL 716
Query: 819 QED-----ELVNRLAVLMDH-----DRVVEKQLLEIEHENKELQKKNQILLEENQNLQIS 868
+ EL+ ++ L + VVEK+LL E E ++ K+ + + +
Sbjct: 717 EASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPE---A 773
Query: 869 LSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTL----IVQKKKE 924
++ + L +K + + SE Y+ Q ++ + ++++T+E Q L + QK+KE
Sbjct: 774 AEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
Score = 59.7 bits (138), Expect = 9e-08
Identities = 71/398 (17%), Positives = 164/398 (41%), Gaps = 26/398 (6%)
Query: 1174 KIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVD-QRG 1232
+I+ L L + +G + I L E++ E D LLS V +LR S++ + Q+
Sbjct: 126 EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
Query: 1233 FEIAELWKQH-LAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQ 1291
E ++ +H ++Q + + Q+ ++E + E K E+ L +Q+ +I ++Q
Sbjct: 186 TERSKEEAEHAISQFQQEIQQRQNEASREFRKKE-KLEKELKQIQADMDSRQTEIKALQQ 244
Query: 1292 -VTSLQNKLQDKEEHLRN---LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXX 1347
V + +LQ E+ L+ L E+ A + Q ++ ++++ E
Sbjct: 245 YVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQ 304
Query: 1348 XXXDLRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTH 1407
+L+ + + QM+ I +N+ Q+ K + +++ L
Sbjct: 305 KALELKAKEEEVHQMR-LDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLER 363
Query: 1408 QLE----------------LKDSEIYQKTHEYTITLTQRNDEFENVRQQLV-EYEKRIED 1450
++E L++ +I K + TQ+ + + +Q E I++
Sbjct: 364 EVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQN 423
Query: 1451 LTYEKESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNK 1510
E + + I+ + + + Y + + + +E++ V+ T+ K++AE
Sbjct: 424 YKDEAQKQRKII-FHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEI 482
Query: 1511 ALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
L+++ +++ +V DEIT+++ ++
Sbjct: 483 KLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLK 520
Score = 54.4 bits (125), Expect = 3e-06
Identities = 94/592 (15%), Positives = 243/592 (41%), Gaps = 43/592 (7%)
Query: 1005 EQYINEINKLNALLKQKDEEIIALNQKINNA-QVSY--MSMVSDYESKLAQFTTKLENME 1061
+ Y NE +L A ++ + EI+ + K+ A ++S + ++ + ++ + +++
Sbjct: 52 KSYDNE-KRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAY 110
Query: 1062 EEMQRVSKQLLDSKQHNEELQILVREQD----DQIKELKETKLTFEMNIPKTEGMIISST 1117
++ Q+ + +L K+ L LV + DQ +++ L F+ + K ++S
Sbjct: 111 DKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL-LRFKEEVTKERDQLLSEV 169
Query: 1118 IEPMSDDANNVDXXXXXXXXXXXXLK-VQEEEEFIQERS--VLQE--QSAKLNTELQECY 1172
++ A + + + ++ IQ+R +E + KL EL++
Sbjct: 170 VKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQ 229
Query: 1173 TKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAE--LRSSISSAVDQ 1230
+ +T L + ++E++ +L+ +L++ N+ + + +R++ ++
Sbjct: 230 ADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENE 289
Query: 1231 RGFEIAELWKQHLAQREADFQKTE---HELRVQLSAFESKYEQLLDSVQSSTQE----ET 1283
+ + E Q Q+ + + E H++R+ + EQ+ + + + E
Sbjct: 290 QHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQ 349
Query: 1284 NKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXX 1343
+K Q+ L+ +++ ++ ++ +++ + +IL + + V
Sbjct: 350 HKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNML-KAVNATQKQTDLVK 408
Query: 1344 XXXXXXXDLRTENQSYK---QMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEA 1400
+L E Q+YK Q Q + I ++ +E + + + E
Sbjct: 409 LHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRET 468
Query: 1401 KVLELTHQLELKDSEIYQKTHEYTITLTQRN----------DEFENVRQQLVEYEKRIED 1450
++ + ++ + ++ Q+ + Y + RN DE +++++L ++++
Sbjct: 469 QIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE 528
Query: 1451 LTYE---KESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAE 1507
L + KES L L L+ ET++ E + R + +E + + K +
Sbjct: 529 LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRI 588
Query: 1508 LNKALEEEVAKTNEMQTALENQEI---EIVTLNDEITNLQNMVRASSSKIQK 1556
+ +A E + + E+ + ++I ++V NDE+ L ++ S + K
Sbjct: 589 IAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNK 640
Score = 52.8 bits (121), Expect = 1e-05
Identities = 133/776 (17%), Positives = 308/776 (39%), Gaps = 59/776 (7%)
Query: 811 KAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLS 870
K+ ++ I+ + L + D+++ + + E+ E K L+ +Q+ Q +++
Sbjct: 34 KSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIA 93
Query: 871 DMQQHYNALVEKA-NRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLE 929
+++ +EKA D A + K + + L+ + +T L+ Q L
Sbjct: 94 SLKKE----IEKAWKMVDSAYDKEQKAKETILALKEEIVNLTK----LVEQGS----GLS 141
Query: 930 IEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
++ ++ I +R K+ + ++ ++ + V +L L + + + EE +
Sbjct: 142 MDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQ 201
Query: 990 DKHVQKQQTQSPDYT--EQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
+ Q+Q S ++ E+ E+ ++ A + + EI AL Q + ++ + +
Sbjct: 202 QEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLK 261
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK---ETKLTFEM 1104
+ + +E+ R +K +++QH+ + L +E + ELK E +
Sbjct: 262 EQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRL 321
Query: 1105 NIPKTEGM--IISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE-------------EE 1149
+I K + I + D V+ L+ + E +E
Sbjct: 322 DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDE 381
Query: 1150 FIQERSVLQEQSAKLNTELQECYTKIIQL-ETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
++ER +L + K Q+ T +++L E L G +++ + + + L
Sbjct: 382 LLRERDILNKNMLKAVNATQK-QTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEK 440
Query: 1209 ENDNLLSTVAELRSSISSAVDQRGFEIAEL--WKQHLAQREADFQKTEHELRVQLSAFES 1266
E D ++ ++L + ++ ++ +++ +A+ E K + L + + +
Sbjct: 441 ERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL-KQQQNLYEAVRSDRN 499
Query: 1267 KYEQLLDSVQSSTQEETNKI-VTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRS 1325
Y + L Q + K+ + + QV L+ + KE L L + + + E L++
Sbjct: 500 LYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKA 559
Query: 1326 EIED------EKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNINEENAQLKK 1379
E++ E F + E K+ +Q I + +QL +
Sbjct: 560 ELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVR 619
Query: 1380 SSXXXXXXXXXXXXR---VNDAEAKVLELTHQLELKDSEIYQKTHEYTI------TLTQR 1430
+ + +N E++ + + + EI + E I + +
Sbjct: 620 RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEEL 679
Query: 1431 NDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHE--NANHYETMQKESEIERVKLI 1488
EF +++++L++ R L E E+ L + R + E + N YE +QK +++ +LI
Sbjct: 680 RQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQK-RLI 738
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQ 1544
+ ++ E L ++ +L L+ +A+ + A E ++ TL+D+ L+
Sbjct: 739 SKTE-EVVEKELLLQEKEKLYMELKHVLARQPGPEAA-EQLKLYRRTLHDKKQQLK 792
Score = 49.2 bits (112), Expect = 1e-04
Identities = 81/460 (17%), Positives = 188/460 (40%), Gaps = 39/460 (8%)
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+EE +ER L + KL L + T Q ET ++ ++Q Q +++ + +
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQ--TTEQQQETERSKEEAEHAISQFQ-QEIQQRQNEA 211
Query: 1207 NTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
+ E EL+ I + +D R EI L +Q++ + + + QK E +L+ Q E
Sbjct: 212 SREFRKKEKLEKELKQ-IQADMDSRQTEIKAL-QQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 1267 KYEQL----LDSVQSSTQEETNKIVTME-----QVTSLQNKLQDKEEH--------LRNL 1309
++L + + + + E + +V + Q +L+ K +++E H L +
Sbjct: 270 AAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKI 329
Query: 1310 QEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQM-QEQSIL 1368
+E+ ++ E ++E+E K + ++ ++ +E+ IL
Sbjct: 330 REQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDIL 389
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQKTHEYTITLT 1428
N N A R + E ++ + + + I+ E +
Sbjct: 390 NKNMLKAVNATQKQTDLVKLHEQAKR--NLEGEIQNYKDEAQKQRKIIFHLEKERDRYIN 447
Query: 1429 QRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKLI 1488
Q +D + V + + + R E ++ ++A +K+ + N YE ++ + + L+
Sbjct: 448 QASDLTQKVLMNMEDIKVR-ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLV 506
Query: 1489 EELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVR 1548
E + ++ ++ + L+ + + +E++ + +E +V L+ E ++
Sbjct: 507 EAQD-----------EITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKE 555
Query: 1549 ASSSKIQKHVSFASDTKQGRDEQLDNTMNKELLDAVPRAE 1588
+++QK A +TK ++Q ++LL + A+
Sbjct: 556 TLKAELQKLRQQALETKHFIEKQ--EAEERKLLRIIAEAD 593
Score = 40.7 bits (91), Expect = 0.042
Identities = 58/321 (18%), Positives = 128/321 (39%), Gaps = 19/321 (5%)
Query: 1249 DFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRN 1308
D + + E+ + S+ +L +S+ +T+++ + E+ ++ + ++ ++
Sbjct: 150 DLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEA---EHAISQFQQEIQQ 206
Query: 1309 LQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSIL 1368
Q + + + E L E++ + + +Q++EQ IL
Sbjct: 207 RQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKIL 266
Query: 1369 NINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQ---LELKDSEIYQKTHEYTI 1425
N E A + + + L +Q LELK E ++ H+ +
Sbjct: 267 N---ERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKE--EEVHQMRL 321
Query: 1426 TLTQRNDEFENVRQQLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERV 1485
+ + N +R+Q+ + ED E E L+ ++ E +K++E++R
Sbjct: 322 DIGKLN----KIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDR- 376
Query: 1486 KLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQN 1545
K ++EL + E LNK + + A +++ + A N E EI DE +
Sbjct: 377 KAMDEL---LRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
Query: 1546 MVRASSSKIQKHVSFASDTKQ 1566
++ + ++++ ASD Q
Sbjct: 434 IIFHLEKERDRYINQASDLTQ 454
>BC010629-1|AAH10629.1| 763|Homo sapiens outer dense fiber of sperm
tails 2 protein.
Length = 763
Score = 81.0 bits (191), Expect = 3e-14
Identities = 141/736 (19%), Positives = 318/736 (43%), Gaps = 94/736 (12%)
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
+L+D+S D K +++ID+L + L ++ K +++ +++ + +
Sbjct: 38 RLSDLSTEDDDS--GHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEE 95
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---- 758
E++ ++L EN L +E+M EK +L K + +++ + ++A++
Sbjct: 96 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 155
Query: 759 -ERDLYIENIESELSKYKSRICR-----------LEESIAVMEDRRYSL-----ERKADQ 801
++ + +++ +L K C L + ++ E+ +L E+ +
Sbjct: 156 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE 215
Query: 802 LGSYLQEKQKAYSEYTIQED-ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
L E+Q A + + D E L +L D D+ VE+ L EI+ E + + ++
Sbjct: 216 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE---- 271
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L S+ M+ H A + E+E+++ Q++ NL+R ++H+ +
Sbjct: 272 ----LSKSMESMRGHLQAQLRS------KEAENSRLCMQIK----NLERSGNQHKAEVEA 317
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIEN 973
+++++L+ + + ES + + E+ EK+ EY QL QL E + +E+
Sbjct: 318 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 377
Query: 974 ----LNMNVEELNKMNLELI---DK---HVQKQQTQSPDYTEQYINEINKLN------AL 1017
N V+E + LE+I D+ V +QQT E + + +L+ +
Sbjct: 378 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 437
Query: 1018 LKQKDEEIIA----LNQKINNAQV----------SYMSMVSDYESKLAQFTTKLENMEEE 1063
K ++E + A + K+N A + +Y M+ +Y+S++ + + + + +
Sbjct: 438 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 497
Query: 1064 MQRVSKQ-LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
++R K+ + + N+E++ R+ Q+ +L++ ++ TE + +
Sbjct: 498 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKI----TEAKLAECQDQLQG 553
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+D ++ E +E+ Q+++ +L+ ++ E K+
Sbjct: 554 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ 613
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N E +E I+Q + +LE+ E L +L S+I A Q E K+
Sbjct: 614 NIEFLQVIAKREEAIHQSQLRLEEKTRECGTL---ARQLESAIEDARRQ-----VEQTKE 665
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQ 1300
H +E Q +L QLS +++ QL S + + +++ + +++ ++ +
Sbjct: 666 HALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 725
Query: 1301 DKEEHLRNLQEKYADV 1316
+ +++ L+ YA+V
Sbjct: 726 SMQNYVQFLKSSYANV 741
Score = 77.8 bits (183), Expect = 3e-13
Identities = 136/680 (20%), Positives = 291/680 (42%), Gaps = 66/680 (9%)
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
I R+ EE + L++EK L LV+ + M + K+++ +++ +LK
Sbjct: 117 IERMKEEKDFTILQKKHLQQEKECLMSKLVEAE---MDGAAAAKQVMALKDTIG-KLKTE 172
Query: 617 SLLESQKFD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+ + L ++ +L QK E+ + L +Q C E S L EQ AL
Sbjct: 173 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE-DSERLMEQQGAL---L 228
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
K LA +K +L ++D + + E+++ ++Q +K + +A ++S+
Sbjct: 229 KRLA----EADSEKARLLLLLQDKDKEVEELLQEIQ---------CEKAQAKTASELSKS 275
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
+ + Q++++++ +A+ + I+N+E +++K+ E A+ME + L
Sbjct: 276 MESMRGHLQAQLRSK---EAENSRLCMQIKNLERSGNQHKA------EVEAIMEQLK-EL 325
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV-LMDHDRVVEKQLLEIEHENKELQKK 854
++K D+ L++ +A E + +E +L V L D D V + L +E +
Sbjct: 326 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR---SRY 382
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
NQ+ ++E +L++ + +V TDL + T + D +S ++R+ H
Sbjct: 383 NQV-VKEKGDLELEI---------IVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-HRQ 431
Query: 915 QTLIVQKKKEIEDLEIEF---NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI 971
K E E L+ F ++ A + + L + + ++Q+ + +
Sbjct: 432 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 491
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ + +E +K N L D+ ++ + + Q + ++ +L +LK + ++ +
Sbjct: 492 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ-LADLQQLPDILKITEAKLAECQDQ 550
Query: 1032 INNAQ---VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ + + +++SD S++ KLE E+ Q S++ N++L + V E
Sbjct: 551 LQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA-------SQKENKQLSLKVDEL 603
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISS--TIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ +++ + F I K E I S +E + + + Q
Sbjct: 604 ERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQT 663
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+E + + Q + L T+L T++ QL + D Q ++ LK +LEQ
Sbjct: 664 KEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDA---DRRYQSRLQDLKDRLEQS 720
Query: 1207 NTENDNLLSTVAELRSSISS 1226
+ N ++ + V L+SS ++
Sbjct: 721 ESTNRSMQNYVQFLKSSYAN 740
Score = 46.8 bits (106), Expect = 6e-04
Identities = 86/451 (19%), Positives = 182/451 (40%), Gaps = 23/451 (5%)
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
ER + + + EL+E ++ + E NT L + +E+ + + + L E +
Sbjct: 81 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 140
Query: 1213 LLSTVAELRSSISSAVDQ---RGFEIAEL-WKQHLAQREADFQKTEHELRVQ-LSAFESK 1267
L+S + E ++A Q I +L ++ + + + + EL +Q LS FE
Sbjct: 141 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 200
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L D ++ +E ++ + MEQ +L +L + + L D ++E L EI
Sbjct: 201 NRTLRDLLREQHCKEDSERL-MEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 259
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN--EENAQLKKSSXXXX 1385
+ EK A L+ + +S + + + I E + K+
Sbjct: 260 QCEK-AQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 318
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK-THEYTITLTQRNDEFENVRQQLVEY 1444
+ D + + L+ + + + +E ++ + + L ++ L +
Sbjct: 319 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 378
Query: 1445 EKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
R + EK E E+ +L ++ + N +T++++ +R L+E L+ + E +
Sbjct: 379 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 438
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+ N+ L+ A M+ L +E+ L + N + M+ S++ K
Sbjct: 439 KLE----NERLKASFA---PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK-TRLE 490
Query: 1562 SDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+D + E+ D NK L D + + E++ A
Sbjct: 491 ADEVAAQLERCDKE-NKILKDEMNK-EIEAA 519
Score = 42.3 bits (95), Expect = 0.014
Identities = 87/522 (16%), Positives = 193/522 (36%), Gaps = 27/522 (5%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
LE +EE++ V+ +L +++ N L R +++KE K+ + + ++ + + ++S
Sbjct: 89 LEERKEELEEVAHELAETEHENTVL----RHNIERMKEEKDFTILQKKHLQQEKECLMSK 144
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+E D A LK +++ ++ +++ L T
Sbjct: 145 LVEAEMDGAAAAKQVMALKDTIGK-LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRT 203
Query: 1177 QLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ L + D EQ L +L + ++E LL + + + + + E
Sbjct: 204 LRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEK 263
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQ 1291
A+ + ++ + L+ QL + E++ +L ++ S Q + MEQ
Sbjct: 264 AQA--KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQ 321
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L+ K +E L+ + + E ++ +
Sbjct: 322 LKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ-------LADKDLYVAEALST 374
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
L + Y Q+ ++ ++ E L ++ + ++E H+
Sbjct: 375 LESWRSRYNQVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 433
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
+ S + + D+ QQL K E + +S++ RL+ E
Sbjct: 434 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 493
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
A E KE++I + ++ +E+ + S + +L L+ AK E Q L+
Sbjct: 494 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 553
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKI----QKHVSFASDTKQ 1566
E + + L I++L++ + K+ +KH + + KQ
Sbjct: 554 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQ 595
>AY366499-1|AAQ73195.1| 805|Homo sapiens outer dense fiber of sperm
tails 2 protein.
Length = 805
Score = 81.0 bits (191), Expect = 3e-14
Identities = 141/736 (19%), Positives = 318/736 (43%), Gaps = 94/736 (12%)
Query: 643 KLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLEND 702
+L+D+S D K +++ID+L + L ++ K +++ +++ + +
Sbjct: 80 RLSDLSTEDDDS--GHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEE 137
Query: 703 KEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQ---- 758
E++ ++L EN L +E+M EK +L K + +++ + ++A++
Sbjct: 138 LEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAA 197
Query: 759 -ERDLYIENIESELSKYKSRICR-----------LEESIAVMEDRRYSL-----ERKADQ 801
++ + +++ +L K C L + ++ E+ +L E+ +
Sbjct: 198 AKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE 257
Query: 802 LGSYLQEKQKAYSEYTIQED-ELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
L E+Q A + + D E L +L D D+ VE+ L EI+ E + + ++
Sbjct: 258 DSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASE---- 313
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
L S+ M+ H A + E+E+++ Q++ NL+R ++H+ +
Sbjct: 314 ----LSKSMESMRGHLQAQLRS------KEAENSRLCMQIK----NLERSGNQHKAEVEA 359
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQL-------QEYKNNIEN 973
+++++L+ + + ES + + E+ EK+ EY QL QL E + +E+
Sbjct: 360 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLES 419
Query: 974 ----LNMNVEELNKMNLELI---DK---HVQKQQTQSPDYTEQYINEINKLN------AL 1017
N V+E + LE+I D+ V +QQT E + + +L+ +
Sbjct: 420 WRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSA 479
Query: 1018 LKQKDEEIIA----LNQKINNAQV----------SYMSMVSDYESKLAQFTTKLENMEEE 1063
K ++E + A + K+N A + +Y M+ +Y+S++ + + + + +
Sbjct: 480 FKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQ 539
Query: 1064 MQRVSKQ-LLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMS 1122
++R K+ + + N+E++ R+ Q+ +L++ ++ TE + +
Sbjct: 540 LERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKI----TEAKLAECQDQLQG 595
Query: 1123 DDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVLQEQSAKLNTELQECYTKIIQLETL 1181
+ N+D ++ E +E+ Q+++ +L+ ++ E K+
Sbjct: 596 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQ 655
Query: 1182 NTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQ 1241
N E +E I+Q + +LE+ E L +L S+I A Q E K+
Sbjct: 656 NIEFLQVIAKREEAIHQSQLRLEEKTRECGTL---ARQLESAIEDARRQ-----VEQTKE 707
Query: 1242 HLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTM-EQVTSLQNKLQ 1300
H +E Q +L QLS +++ QL S + + +++ + +++ ++ +
Sbjct: 708 HALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNR 767
Query: 1301 DKEEHLRNLQEKYADV 1316
+ +++ L+ YA+V
Sbjct: 768 SMQNYVQFLKSSYANV 783
Score = 77.8 bits (183), Expect = 3e-13
Identities = 136/680 (20%), Positives = 291/680 (42%), Gaps = 66/680 (9%)
Query: 557 IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAI 616
I R+ EE + L++EK L LV+ + M + K+++ +++ +LK
Sbjct: 159 IERMKEEKDFTILQKKHLQQEKECLMSKLVEAE---MDGAAAAKQVMALKDTIG-KLKTE 214
Query: 617 SLLESQKFD-LVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASK 675
+ + L ++ +L QK E+ + L +Q C E S L EQ AL
Sbjct: 215 KQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKE-DSERLMEQQGAL---L 270
Query: 676 KELALVIENLKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISEL 735
K LA +K +L ++D + + E+++ ++Q +K + +A ++S+
Sbjct: 271 KRLA----EADSEKARLLLLLQDKDKEVEELLQEIQ---------CEKAQAKTASELSKS 317
Query: 736 LAKINHEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSL 795
+ + Q++++++ +A+ + I+N+E +++K+ E A+ME + L
Sbjct: 318 MESMRGHLQAQLRSK---EAENSRLCMQIKNLERSGNQHKA------EVEAIMEQLK-EL 367
Query: 796 ERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAV-LMDHDRVVEKQLLEIEHENKELQKK 854
++K D+ L++ +A E + +E +L V L D D V + L +E +
Sbjct: 368 KQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWR---SRY 424
Query: 855 NQILLEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEH 914
NQ+ ++E +L++ + +V TDL + T + D +S ++R+ H
Sbjct: 425 NQV-VKEKGDLELEI---------IVLNDRVTDLVNQQQTLEEKMREDRDSLVERL-HRQ 473
Query: 915 QTLIVQKKKEIEDLEIEF---NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNI 971
K E E L+ F ++ A + + L + + ++Q+ + +
Sbjct: 474 TAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 533
Query: 972 ENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQK 1031
+ + +E +K N L D+ ++ + + Q + ++ +L +LK + ++ +
Sbjct: 534 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ-LADLQQLPDILKITEAKLAECQDQ 592
Query: 1032 INNAQ---VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
+ + + +++SD S++ KLE E+ Q S++ N++L + V E
Sbjct: 593 LQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQA-------SQKENKQLSLKVDEL 645
Query: 1089 DDQIKELKETKLTFEMNIPKTEGMIISS--TIEPMSDDANNVDXXXXXXXXXXXXLKVQE 1146
+ +++ + F I K E I S +E + + + Q
Sbjct: 646 ERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQT 705
Query: 1147 EEEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQL 1206
+E + + Q + L T+L T++ QL + D Q ++ LK +LEQ
Sbjct: 706 KEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDA---DRRYQSRLQDLKDRLEQS 762
Query: 1207 NTENDNLLSTVAELRSSISS 1226
+ N ++ + V L+SS ++
Sbjct: 763 ESTNRSMQNYVQFLKSSYAN 782
Score = 46.8 bits (106), Expect = 6e-04
Identities = 86/451 (19%), Positives = 182/451 (40%), Gaps = 23/451 (5%)
Query: 1153 ERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDN 1212
ER + + + EL+E ++ + E NT L + +E+ + + + L E +
Sbjct: 123 ERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKEC 182
Query: 1213 LLSTVAELRSSISSAVDQ---RGFEIAEL-WKQHLAQREADFQKTEHELRVQ-LSAFESK 1267
L+S + E ++A Q I +L ++ + + + + EL +Q LS FE
Sbjct: 183 LMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEET 242
Query: 1268 YEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEI 1327
L D ++ +E ++ + MEQ +L +L + + L D ++E L EI
Sbjct: 243 NRTLRDLLREQHCKEDSERL-MEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEI 301
Query: 1328 EDEKVAFXXXXXXXXXXXXXXXXDLRTENQSYKQMQEQSILNIN--EENAQLKKSSXXXX 1385
+ EK A L+ + +S + + + I E + K+
Sbjct: 302 QCEK-AQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAI 360
Query: 1386 XXXXXXXXRVNDAEAKVLELTHQLELKDSEIYQK-THEYTITLTQRNDEFENVRQQLVEY 1444
+ D + + L+ + + + +E ++ + + L ++ L +
Sbjct: 361 MEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESW 420
Query: 1445 EKRIEDLTYEK---ESELAILRLKMHENANHYETMQKESEIERVKLIEELNVKITESVSL 1501
R + EK E E+ +L ++ + N +T++++ +R L+E L+ + E +
Sbjct: 421 RSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAF 480
Query: 1502 NKQVAELNKALEEEVAKTNEMQTALENQEIEIVTLNDEITNLQNMVRASSSKIQKHVSFA 1561
+ N+ L+ A M+ L +E+ L + N + M+ S++ K
Sbjct: 481 KLE----NERLKASFA---PMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMK-TRLE 532
Query: 1562 SDTKQGRDEQLDNTMNKELLDAVPRAELDLA 1592
+D + E+ D NK L D + + E++ A
Sbjct: 533 ADEVAAQLERCDKE-NKILKDEMNK-EIEAA 561
Score = 42.3 bits (95), Expect = 0.014
Identities = 87/522 (16%), Positives = 193/522 (36%), Gaps = 27/522 (5%)
Query: 1057 LENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPKTEGMIISS 1116
LE +EE++ V+ +L +++ N L R +++KE K+ + + ++ + + ++S
Sbjct: 131 LEERKEELEEVAHELAETEHENTVL----RHNIERMKEEKDFTILQKKHLQQEKECLMSK 186
Query: 1117 TIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNTELQECYTKII 1176
+E D A LK +++ ++ +++ L T
Sbjct: 187 LVEAEMDGAAAAKQVMALKDTIGK-LKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRT 245
Query: 1177 QLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEI 1235
+ L + D EQ L +L + ++E LL + + + + + E
Sbjct: 246 LRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEK 305
Query: 1236 AELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQ----SSTQEETNKIVTMEQ 1291
A+ + ++ + L+ QL + E++ +L ++ S Q + MEQ
Sbjct: 306 AQA--KTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQ 363
Query: 1292 VTSLQNKLQDKEEHLRNLQEKYADVINQIEILRSEIEDEKVAFXXXXXXXXXXXXXXXXD 1351
+ L+ K +E L+ + + E ++ +
Sbjct: 364 LKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQ-------LADKDLYVAEALST 416
Query: 1352 LRTENQSYKQMQEQSILNINEENAQLKKSSXXXXXXXXXXXXRVNDAEAKVLELTHQLEL 1411
L + Y Q+ ++ ++ E L ++ + ++E H+
Sbjct: 417 LESWRSRYNQVVKEKG-DLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTA 475
Query: 1412 KDSEIYQKTHEYTITLTQRNDEFENVR---QQLVEYEKRIEDLTYEKESELAILRLKMHE 1468
+ S + + D+ QQL K E + +S++ RL+ E
Sbjct: 476 EYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADE 535
Query: 1469 NANHYETMQKESEIERVKLIEELNVKITESVSLNKQVAELNKALEEEVAKTNEMQTALEN 1528
A E KE++I + ++ +E+ + S + +L L+ AK E Q L+
Sbjct: 536 VAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQG 595
Query: 1529 QEIEIVTLNDEITNLQNMVRASSSKI----QKHVSFASDTKQ 1566
E + + L I++L++ + K+ +KH + + KQ
Sbjct: 596 YERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQ 637
>AL590005-3|CAI14988.1| 5457|Homo sapiens dystonin protein.
Length = 5457
Score = 81.0 bits (191), Expect = 3e-14
Identities = 263/1381 (19%), Positives = 561/1381 (40%), Gaps = 138/1381 (9%)
Query: 314 GSLEIANMTELTKKIELLEHLNC-QIRQTNKE---LENKLATMGTESKAVSSPSKKGSPL 369
G+ ++ E TKK++ L +I++ N L N ++ + T +KA+++ G+ L
Sbjct: 2317 GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2376
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQD-TDKK--------INKNEIAKLEMVIQSLNKD 420
+G TA+ + W+ ++ +D TD + K++IA+L + L K
Sbjct: 2377 ----NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
Query: 421 LVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ + + + + DT + Q+E + E + N V E
Sbjct: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA----ELKQNVNKVQE 2488
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN----DEIDAANKNMIK---VK 530
+ +L +E D + K ++ ++ S +++ QL +++ ++ N+ + V+
Sbjct: 2489 LKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVE 2548
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ K L + + + +S + +++ L Q+ A + + QL
Sbjct: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE--QLTAAGQGI 2606
Query: 591 GRMIESDVYKKMIEMENLAETRLKAISLLE--SQKFDLVQELHILQQKYDEV----EDKL 644
D + I E LA K SL S + D + + + +Y + DKL
Sbjct: 2607 LSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2666
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK---EQLYGTIKDLEN 701
+D+ S + + +Q++ K+E+ + +K+ + E L +K+ E
Sbjct: 2667 SDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE-EY 2725
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD 761
K ++ +L+ ++ D+ K E + + A + +Q Q +D K +E++
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAEN-HVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
Query: 762 ------LYIENIESELSKYKSRICRL-------EESIAVMED---RRYSLERKADQLG-S 804
++ +ES + +K L E++IA E+ + E+ A QL +
Sbjct: 2785 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2844
Query: 805 YLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEEN 862
++ +++ + E++L L + + VE I+ L++ L E
Sbjct: 2845 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2904
Query: 863 QN----LQISLSDMQQHYNALVEKANRT-----DLAESESTKYQTQLRDLESNLKRITHE 913
+N L+ +M QH+ +VE N T + E + + + L + +T +
Sbjct: 2905 ENSIAKLKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 2963
Query: 914 HQTL------IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + QK KE +++ E Q++ A +++ +++ Y + LQ
Sbjct: 2964 LHSKKFCLENMTQKFKEFQEVSKESKRQLQCA-KEQLDIHDSLGSQA-YSNKYLTMLQTQ 3021
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +++ L V+ ++ +L+ + + T D Q + + L +Q DE+
Sbjct: 3022 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSF 3079
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---EEMQRVSKQLLDSKQHNEELQIL 1084
L K+ + + + + S+ A+F +L++M + + + KQ K ++L+ L
Sbjct: 3080 LETKLQGIG-HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3138
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV-DXXXXXXXXXXXXLK 1143
+ D+ K K T E + P G I +E +S N + D +K
Sbjct: 3139 MASNDNANKTCKMMLATEETS-PDLVG--IKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3195
Query: 1144 VQEE-EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
EE ++E S+L Q A+ + E Q ++ ET+N +L V +E+I L+ K
Sbjct: 3196 RLEEFYSKLKEFSILL-QKAEEHEESQGPVG--METETINQQLNMFKVFQKEEIEPLQGK 3252
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK---QHLAQREADFQKTEHELRV 1259
+ +N L+ + A +S+ + ++ ++ WK + +AQR A Q E +
Sbjct: 3253 QQDVNWLGQGLIQSAA--KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQ----EALL 3306
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEKYADVIN 1318
F+ E LL S +T ++V ++ S + K+ + + + LQ D +
Sbjct: 3307 HCGRFQDALESLL-----SWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKS 3361
Query: 1319 QIEILRSEIEDEKVAFXXX-XXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNINEENAQ 1376
+E+++ E EK+A D R E K + + + + I+ Q
Sbjct: 3362 TVEVIKR--EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3419
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAE-----AKVLE--LTHQLELKDSEIYQKTHEYTITLTQ 1429
++ R+ + E A LE + L+D I H +
Sbjct: 3420 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3479
Query: 1430 RNDEFENVRQ--QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
++ + + R+ +V+ + + Y + E + R ++ + A + E E+E +
Sbjct: 3480 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3539
Query: 1488 IEELNVKITE-------SVSLNKQVAELNKALEEEV--AKTNEMQTALENQEIEIVTLND 1538
+ E++ K+++ + L KQ +EL + L+E++ K N Q L E+ T D
Sbjct: 3540 LNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGD 3598
Query: 1539 EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD-----NTMNKELLDAVPRAELDLAM 1593
E+ +Q+ + A ++ + ++D + ++ L ++ ++EL + + E++L
Sbjct: 3599 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3658
Query: 1594 Y 1594
Y
Sbjct: 3659 Y 3659
Score = 67.3 bits (157), Expect = 4e-10
Identities = 176/873 (20%), Positives = 365/873 (41%), Gaps = 99/873 (11%)
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKE--- 556
+ + +K A + + +L +E K++ + K H K K++QK + N SK + D+ K
Sbjct: 1414 MTQYIKFAGDSLKRLEEE----EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKP 1469
Query: 557 -IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
+ +S K +L E +QL L + +M + + + +++ L E+
Sbjct: 1470 PFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD-KMTDEERNELEKQVKTLQESYNLL 1528
Query: 616 IS-----LLESQKF-DLVQELHILQQKYDEVEDKLADISQLQS---DQVCSEIKSVHLEE 666
S L ESQ D+ E I+ ++ E ++KL I L + +++ ++ + +
Sbjct: 1529 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1588
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLEN------------DKEDIMNKLQNY- 713
L + + + ++++ + L +K+ EN DK I KL
Sbjct: 1589 GTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAK 1648
Query: 714 IQ-ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE--SE 770
I+ E ++L + K +K+ K E+ + ++ KI+ ++ N++ SE
Sbjct: 1649 IKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE 1708
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
+ K + + E S + D++ L E T QE+ V
Sbjct: 1709 RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVK 1768
Query: 831 MDHDRVVEK-QLLEIEHENKE--LQKKNQILL-EENQNLQISLSDMQQHYN-ALVEKANR 885
H++++ + Q + I ++ + L+K+ Q L EE + LQ ++ +++ HY AL E +
Sbjct: 1769 AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKK 1828
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI---EFNTQIESAIRD 942
L S Q +L +++ H Q Q ++E+E+LE + N + R
Sbjct: 1829 MKLTHS----LQEELEKFDADYTEFEHWLQ----QSEQELENLEAGADDINGLMTKLKRQ 1880
Query: 943 KKVLNE--KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS 1000
K + ++ ++ Y+T ++ E + + K++ + VQ++ +
Sbjct: 1881 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSK-----RDGGKVDTSATHREVQRKLDHA 1935
Query: 1001 PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
D ++ N L LK +++ Q +A ++ + E+ ++ + E +
Sbjct: 1936 TDRFRSLYSKCNVLGNNLK----DLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPI 1989
Query: 1061 EEEMQRVSKQLLDSKQHNEEL---QILVREQDDQIKELKETK---LTFEMNIPKTEGMII 1114
+ + + +QL ++K ++ Q+ V + + L + + L + +I KT I+
Sbjct: 1990 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2049
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE-EEFIQ-----ERSVLQEQSAKLN-TE 1167
E +S N + L VQ+ +E + E S+ ++ LN T
Sbjct: 2050 GR-YEDLSKSVN--ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2106
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
LQ+ +K I LE ++ G Q IN + K+++ D ST + L++ +
Sbjct: 2107 LQDIISKNIMLEQ---DIAGR----QSSINAMNEKVKKFMETTDP--STASSLQAKMKD- 2156
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ R E + K+ LA+ E EL+ ++ FE+ E+L +++ TQ T V
Sbjct: 2157 LSARFSEASHKHKETLAKME--------ELKTKVELFENLSEKLQTFLETKTQALTEVDV 2208
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ VT L +Q+ +K+ +V++ +
Sbjct: 2209 PGKDVTELSQYMQESTSEFLE-HKKHLEVLHSL 2240
Score = 62.5 bits (145), Expect = 1e-08
Identities = 179/1044 (17%), Positives = 417/1044 (39%), Gaps = 81/1044 (7%)
Query: 297 KQSIEPSCEEKTEIEEK--GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
K+ ++ C+ T+ E + G E + + T +EL ++ + Q + K+++ +
Sbjct: 1560 KEKLQGICDLLTQTENRLIGHQEAFMIGDGT--VELKKYQSKQ-EELQKDMQGSAQALAE 1616
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
K + K+ +S++ K+ +++ E LN ++ +K E+ K+
Sbjct: 1617 VVKNTENFLKENGEKLSQEDKALIEQKLNE--AKIKCEQLNLKAEQ--SKKELDKVVTTA 1672
Query: 415 QSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
+ V + E T D + +H+Q +E GT+ ++
Sbjct: 1673 IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE-----QNGTHFQE 1727
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
+ + + E+ E+N + + +V ++ + +E + Q ++ A ++ +I
Sbjct: 1728 GDGKSAIGEE--DEVNGNLLETDVDG---QVGTTQENLNQQYQKVKAQHEKIISQHQAVI 1782
Query: 535 LKLKQMQKTIDNFSK-VSDSNKE-IVRLTEELH-HLSQKVAELEEEKG---NLQLHLVDY 588
+ + Q ++ + +S KE + + +EL H +AE E++ +LQ L +
Sbjct: 1783 IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKF 1842
Query: 589 DSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D+ E + + E+ENL L+ K ++ K D ++
Sbjct: 1843 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1902
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
L++ + CS+ ++D SA+ +E+ +++ LY L N+ +D++
Sbjct: 1903 RVLEAAKSCSKRDG----GKVDT-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLV 1957
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY-IEN 766
+K Q+Y + L L+ A L I +D K +R L +
Sbjct: 1958 DKYQHYEDASCGLLAGLQACEATASKHLSEPI------------AVDPKNLQRQLEETKA 2005
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
++ ++S + + +L+++ V+ D R SL + + L + Y + + +E +
Sbjct: 2006 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2065
Query: 827 LAVLMDHDRVVEKQLLEI----EHENKELQKKNQI---------LLEENQNLQISLSDMQ 873
L + + V+ L E+ + L+++ Q+ ++ +N L+ ++ Q
Sbjct: 2066 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2125
Query: 874 QHYNALVEKANRTDLAESEST--KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI- 930
NA+ EK + ST Q +++DL + +H+H+ + + ++ +E+
Sbjct: 2126 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2185
Query: 931 -EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ ++++ + K + + + VT+L +QE + ++E L+ + E+
Sbjct: 2186 ENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEIS 2245
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + T + ++ +K+K E + + ++++ QV +V +S
Sbjct: 2246 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV----LVKSLKSW 2301
Query: 1050 LAQFTTKLENMEEEM--QRVSKQLLDSKQHNEELQILVRE-QDDQIKELKETKLTFEMNI 1106
+ + T K+ ++ + + K L D+K+ E+ + E Q + L +
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2361
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT 1166
P + S ++ + + +K ++ ++ L
Sbjct: 2362 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIK----KDMTDISHGYEDLGLLLKD 2417
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND-NLLSTVAELRSSIS 1225
++ E TK+ +L+ E + + +++N+ +K +Q D + T E S
Sbjct: 2418 KIAELNTKLSKLQKAQEESSAM-MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFE 2476
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELR--VQLSAFESKYE---QLLDSVQSSTQ 1280
+ + Q ++ EL K L + + T R L+ +SK++ QL Q +
Sbjct: 2477 AELKQNVNKVQEL-KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2535
Query: 1281 EETNKIVTMEQV-TSLQNKLQDKE 1303
E +N + + V L+ L +KE
Sbjct: 2536 ESSNNLTQFQTVEAQLKQWLVEKE 2559
Score = 61.7 bits (143), Expect = 2e-08
Identities = 167/876 (19%), Positives = 359/876 (40%), Gaps = 83/876 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ-ITQLND--EIDAANKNMIKV 529
+++ + A+ +EQ + N I +V +++ +L++ E++ I Q+ E D ++++ ++
Sbjct: 1049 QELLKSAEREEQEESVYNLYISEV--RNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1106
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL-QLHLVD- 587
KLK K++++ D+ +++ +E + +EL N+ Q++ +
Sbjct: 1107 TEQEKLK-KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1165
Query: 588 -YDSGRMIESDVYKKMIEMENLA---ETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
Y + V K E L ET+L + + K ++ + L+Q EV++K
Sbjct: 1166 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1225
Query: 644 LADISQLQSD-----QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ + + E+ + E +D K++ ++E + Q+ ++D
Sbjct: 1226 RQVFHALEDELQKAKAISDEMFKTYKERDLD-FDWHKEKADQLVERWQNVHVQIDNRLRD 1284
Query: 699 LENDKE------DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
LE + D + L ++IQ+ K+++ E L ++N ++ + +
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1344
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKA 812
+K+ E Y E + + Y+ + + + R +QE
Sbjct: 1345 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1403
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+ YT + + D + +E++ +E E KE +K + L + N+ +L D
Sbjct: 1404 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDA 1463
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK-----KKEIED 927
++ K + +E STK + QL + ++ +H + + +K+++
Sbjct: 1464 EKAGKPPFSKQKIS--SEEISTK-KEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1520
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
L+ +N +++ + + +E E Q QEYK ++ + + L +
Sbjct: 1521 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQ-QEYKEKLQGI---CDLLTQTENR 1576
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
LI ++ D T E+ K + K EE L + + + + +V + E
Sbjct: 1577 LIG---HQEAFMIGDGTV----ELKK----YQSKQEE---LQKDMQGSAQALAEVVKNTE 1622
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM-NI 1106
+ L + KL +E+ + ++L ++K E+L + + ++ ++ T + E +
Sbjct: 1623 NFLKENGEKLS--QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKV 1680
Query: 1107 PKTEGMIISST-IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ--ERSVLQEQSAK 1163
+ + S T IE + D +NVD + Q F + +S + E+ +
Sbjct: 1681 AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEED-E 1739
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
+N L L T++ G QE +NQ + +++ +++ ++S + +
Sbjct: 1740 VNGNL------------LETDVDGQVGTTQENLNQ---QYQKVKAQHEKIISQHQAVIIA 1784
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
SA + E Q+L+ E + QK EL+V ++ E+ + + S QEE
Sbjct: 1785 TQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM-KLTHSLQEE 1838
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
K T ++ LQ E+ L NL E AD IN
Sbjct: 1839 LEKFDA--DYTEFEHWLQQSEQELENL-EAGADDIN 1871
Score = 59.3 bits (137), Expect = 1e-07
Identities = 176/886 (19%), Positives = 364/886 (41%), Gaps = 84/886 (9%)
Query: 471 NTEDVN-EIAKVQEQLKQE--LNDEIKDVNVKDLIE--------KLKSAEEQITQLNDEI 519
N E + + +K++EQ+ Q L D+I + N K L + K+ S+ E + ++
Sbjct: 3440 NCEPIGTQASKLEEQIAQHKALEDDIINHN-KHLHQAVSIGQSLKVLSSREDKDMVQSKL 3498
Query: 520 DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
D + I+++ + + +Q+ + N + E++ E+H K+++L +
Sbjct: 3499 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---DKLSKLSVQDY 3555
Query: 580 NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+ + R+++ D+ ++ +N+ + L + LL+ D E+ I+Q K +
Sbjct: 3556 STEGLWKQQSELRVLQEDI---LLRKQNVDQALLNGLELLKQTTGD---EVLIIQDKLEA 3609
Query: 640 VEDKLADISQLQSD---------QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
++ + DI++L +D Q+ + S H EE L + EL + +E
Sbjct: 3610 IKARYKDITKLSTDVAKTLEQALQLARRLHSTH-EELCTWLDKVEVELLSYETQVLKGEE 3668
Query: 691 QLYGTIKDLENDKEDIMNK--LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
++ E KE NK L + + + L + + + E + +++A+ N +
Sbjct: 3669 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSD 3728
Query: 749 TQFGIDAKIQERDLYI---ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
T I K++E D I + + S I E+ + + D R LE+ DQ +
Sbjct: 3729 T---ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR--LEQ--DQTSAQ 3781
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
LQ QK ++ ++ ++++ L V H + E E + ++KK +L+ +
Sbjct: 3782 LQ-VQKTFTMEILRHKDIIDDL-VKSGHKIMTACS----EEEKQSMKKKLDKVLKNYDTI 3835
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK--K 923
S+ N+ E + T+ + + S L E++TL Q++ +
Sbjct: 3836 CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHR 3895
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
++ +L E I+ +N+ + +E +QE + L ++E K
Sbjct: 3896 QLRELIAEHKPHIDK-------MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3948
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+D+ + Q TQ D +Q + + ++ L+Q I A +KI Q+S V
Sbjct: 3949 KRAVALDEAI-SQSTQFHDKIDQILESLERIVERLRQ-PPSISAEVEKIKE-QISENKNV 4005
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVS---KQLLDSKQHNEEL--QILVREQDDQIKELKET 1098
S KL L+ EEM S + + +K ++L + + E + E +E
Sbjct: 4006 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREA 4065
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVL 1157
KL M + + S I + D + + + QE E I+E L
Sbjct: 4066 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4125
Query: 1158 QEQ---SAKLNTEL----QECYTKIIQ--LETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
QE+ L +EL E I++ ++ LN+ + +++I++L+ ++
Sbjct: 4126 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4185
Query: 1209 ENDNLLSTV--AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
D L + ++ +++ G ++ E KQ + + + F+ ++ ++++
Sbjct: 4186 YQDGLQAVFDWVDIAGGKLASMSPIGTDL-ETVKQQIEELK-QFKSEAYQQQIEMERLNH 4243
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
+ E LL V EE++K + + L+ EE + N Q K
Sbjct: 4244 QAELLLKKV----TEESDKHTVQDPLMELKLIWDSLEERIINRQHK 4285
Score = 55.6 bits (128), Expect = 1e-06
Identities = 170/872 (19%), Positives = 355/872 (40%), Gaps = 111/872 (12%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE-NKLATMGT-- 354
+ I+ + + ++ E++ +TE KK+ L + + QT+ +L+ K TM
Sbjct: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
+ K G +++ S S K +L N DT +IN +LE
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKK----KLDKVLKNYDTICQINSERYLQLERAQ 3850
Query: 415 QSLNKD----------LVDKEYVISEKDTXXXXXXXXXXGKDT--LIAQLQLEHQQHME- 461
+N+ L + + +IS+ ++ + +L EH+ H++
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3910
Query: 462 ----GPSLIHVGTNTEDVNEIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQL 515
GP L+ + E +QE+ L +IK+ +VK L A Q TQ
Sbjct: 3911 MNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKE-DVKKRAVALDEAISQSTQF 3964
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELE 575
+D+ID +++ ++ + + + ++ + NK + E+L L + + +
Sbjct: 3965 HDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4023
Query: 576 EEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENL----AETRLKAISLLE-SQKF----- 624
EE + D D S + ++ + + + EN+ E K + ++E ++KF
Sbjct: 4024 EEM-IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4082
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
L+ + Q ++ED D S ++ Q +E + E+ID L ++EL +VI N
Sbjct: 4083 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET----IREEIDGL---QEELDIVI-N 4134
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ 744
L + G E DK I+ K + + D +K K +K+ E + Q
Sbjct: 4135 LGSELIAACG-----EPDKP-IVKKSIDELNSAWDSLNKAWKDRIDKLEEAM-------Q 4181
Query: 745 SKIQTQFGIDAKIQERDLY------IENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q G+ A D+ + I ++L K +I L++ + ++ +ER
Sbjct: 4182 AAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4241
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
Q L++ + ++T+Q D ++E +L+ E + + +++++
Sbjct: 4242 NHQAELLLKKVTEESDKHTVQ--------------DPLMELKLIWDSLEERIINRQHKL- 4286
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+ ++L Q + L+ T+ SE + +E L + H Q +
Sbjct: 4287 ----EGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HHVLQNDV 4341
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDK--------KVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + +E + N IES+ ++ +VLN++++ +E Q + QL
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 971 IENLNMNVEELNKMNLELIDKHV--QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
+ + +E+L + L ++H+ K P+ ++ +N ++ A + K+E +L
Sbjct: 4402 AKGFHGEIEDLQQW-LTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4460
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
QK Q E+ + Q + N++E+ + V +L + K EE L E
Sbjct: 4461 MQK---GQQMLARCPKSAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEF 4514
Query: 1089 DDQIKELKE--TKLTFEMNIPKTEGMIISSTI 1118
+ +++ T+ +N+ +I+ + +
Sbjct: 4515 HNSLQDFINWLTQAEQTLNVASRPSLILDTVL 4546
Score = 44.8 bits (101), Expect = 0.003
Identities = 203/1055 (19%), Positives = 421/1055 (39%), Gaps = 111/1055 (10%)
Query: 298 QSIEPSCEEK-TEIEEKGSLEIANMTE---LTKKIELLEHLNCQIRQTNKELENKLATMG 353
QS+ S +K ++++ K S +A T + +++E + + +I+Q K+++ A
Sbjct: 2656 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2715
Query: 354 TESKAVSSPSKKGSPLISR------KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
S V K +SR KS ++ K ++ L S + ++++++
Sbjct: 2716 DLSALVKEEYLKAE--LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2773
Query: 408 AKLEMVIQSLNKDLVDKEYVISEK-DTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
A L+ K+ +K + IS K D TL AQ + + EG +L+
Sbjct: 2774 AWLDT-----KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
Query: 467 HVGTNTEDVNEIAKVQEQLK------QELNDEIKDVN--VKDLIEKLKSAEEQITQLNDE 518
T+ +E A +Q QL N ++K+ +K+ +EK +EQ+ L
Sbjct: 2829 ---LKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
Query: 519 IDAANKNMIKVK--------SNHKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQ 569
ID N+ ++K N KLK +QK +D +F V N L + + +
Sbjct: 2885 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDK 2943
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+V +E K +Q VD M+ ++ K +EN+ +QKF QE
Sbjct: 2944 EVV-TDENKSLIQ--KVD-----MVTEQLHSKKFCLENM------------TQKFKEFQE 2983
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL---VIENLK 686
+ ++ + + DI Q S L+ Q +L A K ++ L + ++L
Sbjct: 2984 VSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3043
Query: 687 LDKEQLYGT---IKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS--AEKISELLAKI-N 740
++ GT + +E ++ Q ++ L KL+ + I E+ ++
Sbjct: 3044 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3103
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+++ G DA+ ++ E I++ L K ++ + + + + + E D
Sbjct: 3104 FDDELDSMAPVGRDAETLQKQK--ETIKAFLKKLEALMASNDNANKTCKMMLATEETSPD 3161
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+G ++ +A S+ Q ++L++R + VE + +E +L K+ ILL+
Sbjct: 3162 LVG--IKRDLEALSK---QCNKLLDRAQA---REEQVEGTIKRLEEFYSKL-KEFSILLQ 3212
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ + + S + + ++ N + + E ++ L+ + + Q LI
Sbjct: 3213 KAEEHEESQGPVGMETETINQQLNMFKVFQKE------EIEPLQGKQQDVNWLGQGLIQS 3266
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL---NMN 977
K +E + ++ K LN+K + + + +++ +E+L ++
Sbjct: 3267 AAKSTSTQGLEHD--LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
Query: 978 VEEL-NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
EEL + V K Q Q ++ +++ ++K++ E+I + + +
Sbjct: 3325 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD--K 3382
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
V + +S +S+ K E +++ +S + ++Q +E L+ L E I++
Sbjct: 3383 VKILKQLSLLDSRWEALLNKAETRNRQLEGIS---VVAQQFHETLEPL-NEWLTTIEKRL 3438
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV---QEEEEFIQE 1153
K E I + + DD N + LKV +E+++ +Q
Sbjct: 3439 VNCEPIGTQASKLEEQIAQH--KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3496
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDN 1212
+ + E ++++Q N ++ G D V +N++ KL +L+ ++
Sbjct: 3497 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD-- 3554
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
ST + V Q E L KQ++ Q + + + ++ + K E +
Sbjct: 3555 -YSTEGLWKQQSELRVLQ---EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3610
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+ T+ T+ T+EQ L +L E L
Sbjct: 3611 KARYKDITKLSTDVAKTLEQALQLARRLHSTHEEL 3645
>AL590005-2|CAI14989.1| 7543|Homo sapiens dystonin protein.
Length = 7543
Score = 81.0 bits (191), Expect = 3e-14
Identities = 263/1381 (19%), Positives = 561/1381 (40%), Gaps = 138/1381 (9%)
Query: 314 GSLEIANMTELTKKIELLEHLNC-QIRQTNKE---LENKLATMGTESKAVSSPSKKGSPL 369
G+ ++ E TKK++ L +I++ N L N ++ + T +KA+++ G+ L
Sbjct: 4403 GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 4462
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQD-TDKK--------INKNEIAKLEMVIQSLNKD 420
+G TA+ + W+ ++ +D TD + K++IA+L + L K
Sbjct: 4463 ----NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 4518
Query: 421 LVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ + + + + DT + Q+E + E + N V E
Sbjct: 4519 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA----ELKQNVNKVQE 4574
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN----DEIDAANKNMIK---VK 530
+ +L +E D + K ++ ++ S +++ QL +++ ++ N+ + V+
Sbjct: 4575 LKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVE 4634
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ K L + + + +S + +++ L Q+ A + + QL
Sbjct: 4635 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE--QLTAAGQGI 4692
Query: 591 GRMIESDVYKKMIEMENLAETRLKAISLLE--SQKFDLVQELHILQQKYDEV----EDKL 644
D + I E LA K SL S + D + + + +Y + DKL
Sbjct: 4693 LSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 4752
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK---EQLYGTIKDLEN 701
+D+ S + + +Q++ K+E+ + +K+ + E L +K+ E
Sbjct: 4753 SDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE-EY 4811
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD 761
K ++ +L+ ++ D+ K E + + A + +Q Q +D K +E++
Sbjct: 4812 LKAELSRQLEGILKSFKDVEQKAEN-HVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 4870
Query: 762 ------LYIENIESELSKYKSRICRL-------EESIAVMED---RRYSLERKADQLG-S 804
++ +ES + +K L E++IA E+ + E+ A QL +
Sbjct: 4871 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 4930
Query: 805 YLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEEN 862
++ +++ + E++L L + + VE I+ L++ L E
Sbjct: 4931 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 4990
Query: 863 QN----LQISLSDMQQHYNALVEKANRT-----DLAESESTKYQTQLRDLESNLKRITHE 913
+N L+ +M QH+ +VE N T + E + + + L + +T +
Sbjct: 4991 ENSIAKLKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 5049
Query: 914 HQTL------IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + QK KE +++ E Q++ A +++ +++ Y + LQ
Sbjct: 5050 LHSKKFCLENMTQKFKEFQEVSKESKRQLQCA-KEQLDIHDSLGSQA-YSNKYLTMLQTQ 5107
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +++ L V+ ++ +L+ + + T D Q + + L +Q DE+
Sbjct: 5108 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSF 5165
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---EEMQRVSKQLLDSKQHNEELQIL 1084
L K+ + + + + S+ A+F +L++M + + + KQ K ++L+ L
Sbjct: 5166 LETKLQGIG-HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 5224
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV-DXXXXXXXXXXXXLK 1143
+ D+ K K T E + P G I +E +S N + D +K
Sbjct: 5225 MASNDNANKTCKMMLATEETS-PDLVG--IKRDLEALSKQCNKLLDRAQAREEQVEGTIK 5281
Query: 1144 VQEE-EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
EE ++E S+L Q A+ + E Q ++ ET+N +L V +E+I L+ K
Sbjct: 5282 RLEEFYSKLKEFSILL-QKAEEHEESQGPVG--METETINQQLNMFKVFQKEEIEPLQGK 5338
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK---QHLAQREADFQKTEHELRV 1259
+ +N L+ + A +S+ + ++ ++ WK + +AQR A Q E +
Sbjct: 5339 QQDVNWLGQGLIQSAA--KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQ----EALL 5392
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEKYADVIN 1318
F+ E LL S +T ++V ++ S + K+ + + + LQ D +
Sbjct: 5393 HCGRFQDALESLL-----SWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKS 5447
Query: 1319 QIEILRSEIEDEKVAFXXX-XXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNINEENAQ 1376
+E+++ E EK+A D R E K + + + + I+ Q
Sbjct: 5448 TVEVIKR--EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 5505
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAE-----AKVLE--LTHQLELKDSEIYQKTHEYTITLTQ 1429
++ R+ + E A LE + L+D I H +
Sbjct: 5506 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 5565
Query: 1430 RNDEFENVRQ--QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
++ + + R+ +V+ + + Y + E + R ++ + A + E E+E +
Sbjct: 5566 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 5625
Query: 1488 IEELNVKITE-------SVSLNKQVAELNKALEEEV--AKTNEMQTALENQEIEIVTLND 1538
+ E++ K+++ + L KQ +EL + L+E++ K N Q L E+ T D
Sbjct: 5626 LNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGD 5684
Query: 1539 EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD-----NTMNKELLDAVPRAELDLAM 1593
E+ +Q+ + A ++ + ++D + ++ L ++ ++EL + + E++L
Sbjct: 5685 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 5744
Query: 1594 Y 1594
Y
Sbjct: 5745 Y 5745
Score = 62.5 bits (145), Expect = 1e-08
Identities = 179/1044 (17%), Positives = 417/1044 (39%), Gaps = 81/1044 (7%)
Query: 297 KQSIEPSCEEKTEIEEK--GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
K+ ++ C+ T+ E + G E + + T +EL ++ + Q + K+++ +
Sbjct: 3646 KEKLQGICDLLTQTENRLIGHQEAFMIGDGT--VELKKYQSKQ-EELQKDMQGSAQALAE 3702
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
K + K+ +S++ K+ +++ E LN ++ +K E+ K+
Sbjct: 3703 VVKNTENFLKENGEKLSQEDKALIEQKLNE--AKIKCEQLNLKAEQ--SKKELDKVVTTA 3758
Query: 415 QSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
+ V + E T D + +H+Q +E GT+ ++
Sbjct: 3759 IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE-----QNGTHFQE 3813
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
+ + + E+ E+N + + +V ++ + +E + Q ++ A ++ +I
Sbjct: 3814 GDGKSAIGEE--DEVNGNLLETDVDG---QVGTTQENLNQQYQKVKAQHEKIISQHQAVI 3868
Query: 535 LKLKQMQKTIDNFSK-VSDSNKE-IVRLTEELH-HLSQKVAELEEEKG---NLQLHLVDY 588
+ + Q ++ + +S KE + + +EL H +AE E++ +LQ L +
Sbjct: 3869 IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKF 3928
Query: 589 DSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D+ E + + E+ENL L+ K ++ K D ++
Sbjct: 3929 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 3988
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
L++ + CS+ ++D SA+ +E+ +++ LY L N+ +D++
Sbjct: 3989 RVLEAAKSCSKRDG----GKVDT-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLV 4043
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY-IEN 766
+K Q+Y + L L+ A L I +D K +R L +
Sbjct: 4044 DKYQHYEDASCGLLAGLQACEATASKHLSEPI------------AVDPKNLQRQLEETKA 4091
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
++ ++S + + +L+++ V+ D R SL + + L + Y + + +E +
Sbjct: 4092 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 4151
Query: 827 LAVLMDHDRVVEKQLLEI----EHENKELQKKNQI---------LLEENQNLQISLSDMQ 873
L + + V+ L E+ + L+++ Q+ ++ +N L+ ++ Q
Sbjct: 4152 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 4211
Query: 874 QHYNALVEKANRTDLAESEST--KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI- 930
NA+ EK + ST Q +++DL + +H+H+ + + ++ +E+
Sbjct: 4212 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 4271
Query: 931 -EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ ++++ + K + + + VT+L +QE + ++E L+ + E+
Sbjct: 4272 ENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEIS 4331
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + T + ++ +K+K E + + ++++ QV +V +S
Sbjct: 4332 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV----LVKSLKSW 4387
Query: 1050 LAQFTTKLENMEEEM--QRVSKQLLDSKQHNEELQILVRE-QDDQIKELKETKLTFEMNI 1106
+ + T K+ ++ + + K L D+K+ E+ + E Q + L +
Sbjct: 4388 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 4447
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT 1166
P + S ++ + + +K ++ ++ L
Sbjct: 4448 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIK----KDMTDISHGYEDLGLLLKD 4503
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND-NLLSTVAELRSSIS 1225
++ E TK+ +L+ E + + +++N+ +K +Q D + T E S
Sbjct: 4504 KIAELNTKLSKLQKAQEESSAM-MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFE 4562
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELR--VQLSAFESKYE---QLLDSVQSSTQ 1280
+ + Q ++ EL K L + + T R L+ +SK++ QL Q +
Sbjct: 4563 AELKQNVNKVQEL-KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 4621
Query: 1281 EETNKIVTMEQV-TSLQNKLQDKE 1303
E +N + + V L+ L +KE
Sbjct: 4622 ESSNNLTQFQTVEAQLKQWLVEKE 4645
Score = 59.3 bits (137), Expect = 1e-07
Identities = 176/886 (19%), Positives = 364/886 (41%), Gaps = 84/886 (9%)
Query: 471 NTEDVN-EIAKVQEQLKQE--LNDEIKDVNVKDLIE--------KLKSAEEQITQLNDEI 519
N E + + +K++EQ+ Q L D+I + N K L + K+ S+ E + ++
Sbjct: 5526 NCEPIGTQASKLEEQIAQHKALEDDIINHN-KHLHQAVSIGQSLKVLSSREDKDMVQSKL 5584
Query: 520 DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
D + I+++ + + +Q+ + N + E++ E+H K+++L +
Sbjct: 5585 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---DKLSKLSVQDY 5641
Query: 580 NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+ + R+++ D+ ++ +N+ + L + LL+ D E+ I+Q K +
Sbjct: 5642 STEGLWKQQSELRVLQEDI---LLRKQNVDQALLNGLELLKQTTGD---EVLIIQDKLEA 5695
Query: 640 VEDKLADISQLQSD---------QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
++ + DI++L +D Q+ + S H EE L + EL + +E
Sbjct: 5696 IKARYKDITKLSTDVAKTLEQALQLARRLHSTH-EELCTWLDKVEVELLSYETQVLKGEE 5754
Query: 691 QLYGTIKDLENDKEDIMNK--LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
++ E KE NK L + + + L + + + E + +++A+ N +
Sbjct: 5755 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSD 5814
Query: 749 TQFGIDAKIQERDLYI---ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
T I K++E D I + + S I E+ + + D R LE+ DQ +
Sbjct: 5815 T---ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR--LEQ--DQTSAQ 5867
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
LQ QK ++ ++ ++++ L V H + E E + ++KK +L+ +
Sbjct: 5868 LQ-VQKTFTMEILRHKDIIDDL-VKSGHKIMTACS----EEEKQSMKKKLDKVLKNYDTI 5921
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK--K 923
S+ N+ E + T+ + + S L E++TL Q++ +
Sbjct: 5922 CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHR 5981
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
++ +L E I+ +N+ + +E +QE + L ++E K
Sbjct: 5982 QLRELIAEHKPHIDK-------MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 6034
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+D+ + Q TQ D +Q + + ++ L+Q I A +KI Q+S V
Sbjct: 6035 KRAVALDEAI-SQSTQFHDKIDQILESLERIVERLRQ-PPSISAEVEKIKE-QISENKNV 6091
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVS---KQLLDSKQHNEEL--QILVREQDDQIKELKET 1098
S KL L+ EEM S + + +K ++L + + E + E +E
Sbjct: 6092 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREA 6151
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVL 1157
KL M + + S I + D + + + QE E I+E L
Sbjct: 6152 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 6211
Query: 1158 QEQ---SAKLNTEL----QECYTKIIQ--LETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
QE+ L +EL E I++ ++ LN+ + +++I++L+ ++
Sbjct: 6212 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 6271
Query: 1209 ENDNLLSTV--AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
D L + ++ +++ G ++ E KQ + + + F+ ++ ++++
Sbjct: 6272 YQDGLQAVFDWVDIAGGKLASMSPIGTDL-ETVKQQIEELK-QFKSEAYQQQIEMERLNH 6329
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
+ E LL V EE++K + + L+ EE + N Q K
Sbjct: 6330 QAELLLKKV----TEESDKHTVQDPLMELKLIWDSLEERIINRQHK 6371
Score = 57.6 bits (133), Expect = 3e-07
Identities = 171/907 (18%), Positives = 378/907 (41%), Gaps = 96/907 (10%)
Query: 459 HMEGPSLIHVGTNT--EDVNEIAKVQ-EQLKQELNDEIKDVNV--KDLIEKLKSAEEQIT 513
H+E S+ H T ++ ++ + +Q+ ++ E+ + V ++ + KLKS + ++
Sbjct: 3471 HVEELSISHQSLKTAFSSLSNVSSERTKQIMLAIDSEMSKLAVSHEEFLHKLKSFSDWVS 3530
Query: 514 QLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHH-LSQKVA 572
+ + + + ++ V+ + +K K+++ + + + ++ ++ +S+
Sbjct: 3531 EKSKSVK--DIEIVNVQDSEYVK-KRLEFLKNVLKDLGHTKMQLETTAFDVQFFISEYAQ 3587
Query: 573 ELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHI 632
+L + L L++ + DV + + ET+L L+ QK +V E
Sbjct: 3588 DLSPNQSKQLLRLLNTTQKCFL--DVQESVTTQVERLETQLHLEQDLDDQK--IVAER-- 3641
Query: 633 LQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQL 692
QQ+Y E + D+ +++ ++ + + L + + + ++++ + L
Sbjct: 3642 -QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQAL 3700
Query: 693 YGTIKDLEN------------DKEDIMNKLQNY-IQ-ENMDLTDKLEKMSAEKISELLAK 738
+K+ EN DK I KL I+ E ++L + K +K+ K
Sbjct: 3701 AEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 3760
Query: 739 INHEEQSKIQTQFGIDAKIQERDLYIENIE--SELSKYKSRICRLEESIAVMEDRRYSLE 796
E+ + ++ KI+ ++ N++ SE + K + + E S
Sbjct: 3761 EETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAI 3820
Query: 797 RKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEK-QLLEIEHENKE--LQK 853
+ D++ L E T QE+ V H++++ + Q + I ++ + L+K
Sbjct: 3821 GEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEK 3880
Query: 854 KNQILL-EENQNLQISLSDMQQHYN-ALVEKANRTDLAESESTKYQTQLRDLESNLKRIT 911
+ Q L EE + LQ ++ +++ HY AL E + L S Q +L +++
Sbjct: 3881 QGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS----LQEELEKFDADYTEFE 3936
Query: 912 HEHQTLIVQKKKEIEDLEI---EFNTQIESAIRDKKVLNE--KYEKNIEYVTQLEAQLQE 966
H Q Q ++E+E+LE + N + R K + ++ ++ Y+T ++ E
Sbjct: 3937 HWLQ----QSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLE 3992
Query: 967 YKNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEII 1026
+ + K++ + VQ++ + D ++ N L LK +++
Sbjct: 3993 AAKSCSK-----RDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----DLV 4043
Query: 1027 ALNQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEEL---QI 1083
Q +A ++ + E+ ++ + E + + + + +QL ++K ++ Q+
Sbjct: 4044 DKYQHYEDASCGLLAGLQACEATASKHLS--EPIAVDPKNLQRQLEETKALQGQISSQQV 4101
Query: 1084 LVREQDDQIKELKETK---LTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXX 1140
V + + L + + L + +I KT I+ E +S N +
Sbjct: 4102 AVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR-YEDLSKSVN--ERNEKLQITLTR 4158
Query: 1141 XLKVQEE-EEFIQ-----ERSVLQEQSAKLN-TELQECYTKIIQLETLNTELTGHDVVNQ 1193
L VQ+ +E + E S+ ++ LN T LQ+ +K I LE ++ G Q
Sbjct: 4159 SLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ---DIAGR----Q 4211
Query: 1194 EQINQLKSKLEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREADFQKT 1253
IN + K+++ D ST + L++ + + R E + K+ LA+ E
Sbjct: 4212 SSINAMNEKVKKFMETTDP--STASSLQAKMKD-LSARFSEASHKHKETLAKME------ 4262
Query: 1254 EHELRVQLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEKY 1313
EL+ ++ FE+ E+L +++ TQ T V + VT L +Q+ +K+
Sbjct: 4263 --ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE-HKKH 4319
Query: 1314 ADVINQI 1320
+V++ +
Sbjct: 4320 LEVLHSL 4326
Score = 55.6 bits (128), Expect = 1e-06
Identities = 170/872 (19%), Positives = 355/872 (40%), Gaps = 111/872 (12%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE-NKLATMGT-- 354
+ I+ + + ++ E++ +TE KK+ L + + QT+ +L+ K TM
Sbjct: 5821 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 5880
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
+ K G +++ S S K +L N DT +IN +LE
Sbjct: 5881 HKDIIDDLVKSGHKIMTACSEEEKQSMKK----KLDKVLKNYDTICQINSERYLQLERAQ 5936
Query: 415 QSLNKD----------LVDKEYVISEKDTXXXXXXXXXXGKDT--LIAQLQLEHQQHME- 461
+N+ L + + +IS+ ++ + +L EH+ H++
Sbjct: 5937 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 5996
Query: 462 ----GPSLIHVGTNTEDVNEIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQL 515
GP L+ + E +QE+ L +IK+ +VK L A Q TQ
Sbjct: 5997 MNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKE-DVKKRAVALDEAISQSTQF 6050
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELE 575
+D+ID +++ ++ + + + ++ + NK + E+L L + + +
Sbjct: 6051 HDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 6109
Query: 576 EEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENL----AETRLKAISLLE-SQKF----- 624
EE + D D S + ++ + + + EN+ E K + ++E ++KF
Sbjct: 6110 EEM-IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 6168
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
L+ + Q ++ED D S ++ Q +E + E+ID L ++EL +VI N
Sbjct: 6169 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET----IREEIDGL---QEELDIVI-N 6220
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ 744
L + G E DK I+ K + + D +K K +K+ E + Q
Sbjct: 6221 LGSELIAACG-----EPDKP-IVKKSIDELNSAWDSLNKAWKDRIDKLEEAM-------Q 6267
Query: 745 SKIQTQFGIDAKIQERDLY------IENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q G+ A D+ + I ++L K +I L++ + ++ +ER
Sbjct: 6268 AAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 6327
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
Q L++ + ++T+Q D ++E +L+ E + + +++++
Sbjct: 6328 NHQAELLLKKVTEESDKHTVQ--------------DPLMELKLIWDSLEERIINRQHKL- 6372
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+ ++L Q + L+ T+ SE + +E L + H Q +
Sbjct: 6373 ----EGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HHVLQNDV 6427
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDK--------KVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + +E + N IES+ ++ +VLN++++ +E Q + QL
Sbjct: 6428 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 6487
Query: 971 IENLNMNVEELNKMNLELIDKHV--QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
+ + +E+L + L ++H+ K P+ ++ +N ++ A + K+E +L
Sbjct: 6488 AKGFHGEIEDLQQW-LTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 6546
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
QK Q E+ + Q + N++E+ + V +L + K EE L E
Sbjct: 6547 MQK---GQQMLARCPKSAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEF 6600
Query: 1089 DDQIKELKE--TKLTFEMNIPKTEGMIISSTI 1118
+ +++ T+ +N+ +I+ + +
Sbjct: 6601 HNSLQDFINWLTQAEQTLNVASRPSLILDTVL 6632
Score = 44.8 bits (101), Expect = 0.003
Identities = 203/1055 (19%), Positives = 421/1055 (39%), Gaps = 111/1055 (10%)
Query: 298 QSIEPSCEEK-TEIEEKGSLEIANMTE---LTKKIELLEHLNCQIRQTNKELENKLATMG 353
QS+ S +K ++++ K S +A T + +++E + + +I+Q K+++ A
Sbjct: 4742 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 4801
Query: 354 TESKAVSSPSKKGSPLISR------KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
S V K +SR KS ++ K ++ L S + ++++++
Sbjct: 4802 DLSALVKEEYLKAE--LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 4859
Query: 408 AKLEMVIQSLNKDLVDKEYVISEK-DTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
A L+ K+ +K + IS K D TL AQ + + EG +L+
Sbjct: 4860 AWLDT-----KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 4914
Query: 467 HVGTNTEDVNEIAKVQEQLK------QELNDEIKDVN--VKDLIEKLKSAEEQITQLNDE 518
T+ +E A +Q QL N ++K+ +K+ +EK +EQ+ L
Sbjct: 4915 ---LKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 4970
Query: 519 IDAANKNMIKVK--------SNHKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQ 569
ID N+ ++K N KLK +QK +D +F V N L + + +
Sbjct: 4971 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDK 5029
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+V +E K +Q VD M+ ++ K +EN+ +QKF QE
Sbjct: 5030 EVV-TDENKSLIQ--KVD-----MVTEQLHSKKFCLENM------------TQKFKEFQE 5069
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL---VIENLK 686
+ ++ + + DI Q S L+ Q +L A K ++ L + ++L
Sbjct: 5070 VSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 5129
Query: 687 LDKEQLYGT---IKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS--AEKISELLAKI-N 740
++ GT + +E ++ Q ++ L KL+ + I E+ ++
Sbjct: 5130 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 5189
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+++ G DA+ ++ E I++ L K ++ + + + + + E D
Sbjct: 5190 FDDELDSMAPVGRDAETLQKQK--ETIKAFLKKLEALMASNDNANKTCKMMLATEETSPD 5247
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+G ++ +A S+ Q ++L++R + VE + +E +L K+ ILL+
Sbjct: 5248 LVG--IKRDLEALSK---QCNKLLDRAQA---REEQVEGTIKRLEEFYSKL-KEFSILLQ 5298
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ + + S + + ++ N + + E ++ L+ + + Q LI
Sbjct: 5299 KAEEHEESQGPVGMETETINQQLNMFKVFQKE------EIEPLQGKQQDVNWLGQGLIQS 5352
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL---NMN 977
K +E + ++ K LN+K + + + +++ +E+L ++
Sbjct: 5353 AAKSTSTQGLEHD--LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 5410
Query: 978 VEEL-NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
EEL + V K Q Q ++ +++ ++K++ E+I + + +
Sbjct: 5411 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD--K 5468
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
V + +S +S+ K E +++ +S + ++Q +E L+ L E I++
Sbjct: 5469 VKILKQLSLLDSRWEALLNKAETRNRQLEGIS---VVAQQFHETLEPL-NEWLTTIEKRL 5524
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV---QEEEEFIQE 1153
K E I + + DD N + LKV +E+++ +Q
Sbjct: 5525 VNCEPIGTQASKLEEQIAQH--KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 5582
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDN 1212
+ + E ++++Q N ++ G D V +N++ KL +L+ ++
Sbjct: 5583 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD-- 5640
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
ST + V Q E L KQ++ Q + + + ++ + K E +
Sbjct: 5641 -YSTEGLWKQQSELRVLQ---EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 5696
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+ T+ T+ T+EQ L +L E L
Sbjct: 5697 KARYKDITKLSTDVAKTLEQALQLARRLHSTHEEL 5731
Score = 44.0 bits (99), Expect = 0.005
Identities = 101/540 (18%), Positives = 226/540 (41%), Gaps = 48/540 (8%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ-ITQLND--EIDAANKNMIKV 529
+++ + A+ +EQ + N I +V +++ +L++ E++ I Q+ E D ++++ ++
Sbjct: 1049 QELLKSAEREEQEESVYNLYISEV--RNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1106
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL-QLHLVD- 587
KLK K++++ D+ +++ +E + +EL N+ Q++ +
Sbjct: 1107 TEQEKLK-KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1165
Query: 588 -YDSGRMIESDVYKKMIEMENLA---ETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
Y + V K E L ET+L + + K ++ + L+Q EV++K
Sbjct: 1166 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1225
Query: 644 LADISQLQSD-----QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ + + E+ + E +D K++ ++E + Q+ ++D
Sbjct: 1226 RQVFHALEDELQKAKAISDEMFKTYKERDLD-FDWHKEKADQLVERWQNVHVQIDNRLRD 1284
Query: 699 LENDKE------DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
LE + D + L ++IQ+ K+++ E L ++N ++ + +
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1344
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKA 812
+K+ E Y E + + Y+ + + + R +QE
Sbjct: 1345 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1403
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+ YT + + D + +E++ +E E KE +K + L + N+ +L D
Sbjct: 1404 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD- 1462
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEIEF 932
EKA + +K + ++ + ++++ QT+ + K + + E
Sbjct: 1463 -------AEKAGKPPF-----SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE 1510
Query: 933 NTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEE-LNKMNLELIDK 991
++E + K L E Y N+ + L+ QLQE + + + + VEE L+K+ ID+
Sbjct: 1511 RNELEKQV---KTLQESY--NLLFSESLK-QLQESQTSGD---VKVEEKLDKVIAGTIDQ 1561
Score = 35.5 bits (78), Expect = 1.6
Identities = 66/380 (17%), Positives = 167/380 (43%), Gaps = 33/380 (8%)
Query: 764 IENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDEL 823
IEN+ S L +++S + + +ED + +D++ +E+ + + + D+L
Sbjct: 1208 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 1267
Query: 824 VNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL------LEENQNLQISLSDMQ-QHY 876
V R + H + ++ +L ++E K L+ +++ + Q + + Q ++
Sbjct: 1268 VERWQNV--HVQ-IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS 1324
Query: 877 NALVEKANRTDLAESESTKYQTQLRDLESNLKRIT-----HEHQTLIVQKKKEIEDLEIE 931
L + N+ + SE Q+++ + + ++ + +E QT+ + + +
Sbjct: 1325 KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPV 1384
Query: 932 FNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDK 991
+++S+ ++ E + Y + Q K ++L +EE K E +
Sbjct: 1385 KRRRMQSSA--DLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLK-RLEEEEKSLEEEKKE 1441
Query: 992 HVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVS-YMSMVSDYESKL 1050
HV+K + +++++ I+K ++ + + QKI++ ++S +S+ +
Sbjct: 1442 HVEKAKE-----LQKWVSNISKTLKDAEKAGKPPFS-KQKISSEEISTKKEQLSEALQTI 1495
Query: 1051 AQFTTKL--ENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEMNIPK 1108
F K + +EE + KQ+ K E +L E +K+L+E++ + ++ + +
Sbjct: 1496 QLFLAKHGDKMTDEERNELEKQV---KTLQESYNLLFSE---SLKQLQESQTSGDVKVEE 1549
Query: 1109 TEGMIISSTIEPMSDDANNV 1128
+I+ TI+ + + +V
Sbjct: 1550 KLDKVIAGTIDQTTGEVLSV 1569
>AL512448-3|CAI16610.1| 5144|Homo sapiens dystonin protein.
Length = 5144
Score = 81.0 bits (191), Expect = 3e-14
Identities = 263/1381 (19%), Positives = 561/1381 (40%), Gaps = 138/1381 (9%)
Query: 314 GSLEIANMTELTKKIELLEHLNC-QIRQTNKE---LENKLATMGTESKAVSSPSKKGSPL 369
G+ ++ E TKK++ L +I++ N L N ++ + T +KA+++ G+ L
Sbjct: 1991 GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2050
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQD-TDKK--------INKNEIAKLEMVIQSLNKD 420
+G TA+ + W+ ++ +D TD + K++IA+L + L K
Sbjct: 2051 ----NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2106
Query: 421 LVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ + + + + DT + Q+E + E + N V E
Sbjct: 2107 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA----ELKQNVNKVQE 2162
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN----DEIDAANKNMIK---VK 530
+ +L +E D + K ++ ++ S +++ QL +++ ++ N+ + V+
Sbjct: 2163 LKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVE 2222
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ K L + + + +S + +++ L Q+ A + + QL
Sbjct: 2223 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE--QLTAAGQGI 2280
Query: 591 GRMIESDVYKKMIEMENLAETRLKAISLLE--SQKFDLVQELHILQQKYDEV----EDKL 644
D + I E LA K SL S + D + + + +Y + DKL
Sbjct: 2281 LSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2340
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK---EQLYGTIKDLEN 701
+D+ S + + +Q++ K+E+ + +K+ + E L +K+ E
Sbjct: 2341 SDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE-EY 2399
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD 761
K ++ +L+ ++ D+ K E + + A + +Q Q +D K +E++
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQKAEN-HVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2458
Query: 762 ------LYIENIESELSKYKSRICRL-------EESIAVMED---RRYSLERKADQLG-S 804
++ +ES + +K L E++IA E+ + E+ A QL +
Sbjct: 2459 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2518
Query: 805 YLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEEN 862
++ +++ + E++L L + + VE I+ L++ L E
Sbjct: 2519 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2578
Query: 863 QN----LQISLSDMQQHYNALVEKANRT-----DLAESESTKYQTQLRDLESNLKRITHE 913
+N L+ +M QH+ +VE N T + E + + + L + +T +
Sbjct: 2579 ENSIAKLKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 2637
Query: 914 HQTL------IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + QK KE +++ E Q++ A +++ +++ Y + LQ
Sbjct: 2638 LHSKKFCLENMTQKFKEFQEVSKESKRQLQCA-KEQLDIHDSLGSQA-YSNKYLTMLQTQ 2695
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +++ L V+ ++ +L+ + + T D Q + + L +Q DE+
Sbjct: 2696 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSF 2753
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---EEMQRVSKQLLDSKQHNEELQIL 1084
L K+ + + + + S+ A+F +L++M + + + KQ K ++L+ L
Sbjct: 2754 LETKLQGIG-HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 2812
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV-DXXXXXXXXXXXXLK 1143
+ D+ K K T E + P G I +E +S N + D +K
Sbjct: 2813 MASNDNANKTCKMMLATEETS-PDLVG--IKRDLEALSKQCNKLLDRAQAREEQVEGTIK 2869
Query: 1144 VQEE-EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
EE ++E S+L Q A+ + E Q ++ ET+N +L V +E+I L+ K
Sbjct: 2870 RLEEFYSKLKEFSILL-QKAEEHEESQGPVG--METETINQQLNMFKVFQKEEIEPLQGK 2926
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK---QHLAQREADFQKTEHELRV 1259
+ +N L+ + A +S+ + ++ ++ WK + +AQR A Q E +
Sbjct: 2927 QQDVNWLGQGLIQSAA--KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQ----EALL 2980
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEKYADVIN 1318
F+ E LL S +T ++V ++ S + K+ + + + LQ D +
Sbjct: 2981 HCGRFQDALESLL-----SWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKS 3035
Query: 1319 QIEILRSEIEDEKVAFXXX-XXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNINEENAQ 1376
+E+++ E EK+A D R E K + + + + I+ Q
Sbjct: 3036 TVEVIKR--EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3093
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAE-----AKVLE--LTHQLELKDSEIYQKTHEYTITLTQ 1429
++ R+ + E A LE + L+D I H +
Sbjct: 3094 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3153
Query: 1430 RNDEFENVRQ--QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
++ + + R+ +V+ + + Y + E + R ++ + A + E E+E +
Sbjct: 3154 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3213
Query: 1488 IEELNVKITE-------SVSLNKQVAELNKALEEEV--AKTNEMQTALENQEIEIVTLND 1538
+ E++ K+++ + L KQ +EL + L+E++ K N Q L E+ T D
Sbjct: 3214 LNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGD 3272
Query: 1539 EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD-----NTMNKELLDAVPRAELDLAM 1593
E+ +Q+ + A ++ + ++D + ++ L ++ ++EL + + E++L
Sbjct: 3273 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3332
Query: 1594 Y 1594
Y
Sbjct: 3333 Y 3333
Score = 67.3 bits (157), Expect = 4e-10
Identities = 176/873 (20%), Positives = 365/873 (41%), Gaps = 99/873 (11%)
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKE--- 556
+ + +K A + + +L +E K++ + K H K K++QK + N SK + D+ K
Sbjct: 1088 MTQYIKFAGDSLKRLEEE----EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKP 1143
Query: 557 -IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
+ +S K +L E +QL L + +M + + + +++ L E+
Sbjct: 1144 PFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD-KMTDEERNELEKQVKTLQESYNLL 1202
Query: 616 IS-----LLESQKF-DLVQELHILQQKYDEVEDKLADISQLQS---DQVCSEIKSVHLEE 666
S L ESQ D+ E I+ ++ E ++KL I L + +++ ++ + +
Sbjct: 1203 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1262
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLEN------------DKEDIMNKLQNY- 713
L + + + ++++ + L +K+ EN DK I KL
Sbjct: 1263 GTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAK 1322
Query: 714 IQ-ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE--SE 770
I+ E ++L + K +K+ K E+ + ++ KI+ ++ N++ SE
Sbjct: 1323 IKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE 1382
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
+ K + + E S + D++ L E T QE+ V
Sbjct: 1383 RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVK 1442
Query: 831 MDHDRVVEK-QLLEIEHENKE--LQKKNQILL-EENQNLQISLSDMQQHYN-ALVEKANR 885
H++++ + Q + I ++ + L+K+ Q L EE + LQ ++ +++ HY AL E +
Sbjct: 1443 AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKK 1502
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI---EFNTQIESAIRD 942
L S Q +L +++ H Q Q ++E+E+LE + N + R
Sbjct: 1503 MKLTHS----LQEELEKFDADYTEFEHWLQ----QSEQELENLEAGADDINGLMTKLKRQ 1554
Query: 943 KKVLNE--KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS 1000
K + ++ ++ Y+T ++ E + + K++ + VQ++ +
Sbjct: 1555 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSK-----RDGGKVDTSATHREVQRKLDHA 1609
Query: 1001 PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
D ++ N L LK +++ Q +A ++ + E+ ++ + E +
Sbjct: 1610 TDRFRSLYSKCNVLGNNLK----DLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPI 1663
Query: 1061 EEEMQRVSKQLLDSKQHNEEL---QILVREQDDQIKELKETK---LTFEMNIPKTEGMII 1114
+ + + +QL ++K ++ Q+ V + + L + + L + +I KT I+
Sbjct: 1664 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 1723
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE-EEFIQ-----ERSVLQEQSAKLN-TE 1167
E +S N + L VQ+ +E + E S+ ++ LN T
Sbjct: 1724 GR-YEDLSKSVN--ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 1780
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
LQ+ +K I LE ++ G Q IN + K+++ D ST + L++ +
Sbjct: 1781 LQDIISKNIMLEQ---DIAGR----QSSINAMNEKVKKFMETTDP--STASSLQAKMKD- 1830
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ R E + K+ LA+ E EL+ ++ FE+ E+L +++ TQ T V
Sbjct: 1831 LSARFSEASHKHKETLAKME--------ELKTKVELFENLSEKLQTFLETKTQALTEVDV 1882
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ VT L +Q+ +K+ +V++ +
Sbjct: 1883 PGKDVTELSQYMQESTSEFLE-HKKHLEVLHSL 1914
Score = 62.5 bits (145), Expect = 1e-08
Identities = 179/1044 (17%), Positives = 417/1044 (39%), Gaps = 81/1044 (7%)
Query: 297 KQSIEPSCEEKTEIEEK--GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
K+ ++ C+ T+ E + G E + + T +EL ++ + Q + K+++ +
Sbjct: 1234 KEKLQGICDLLTQTENRLIGHQEAFMIGDGT--VELKKYQSKQ-EELQKDMQGSAQALAE 1290
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
K + K+ +S++ K+ +++ E LN ++ +K E+ K+
Sbjct: 1291 VVKNTENFLKENGEKLSQEDKALIEQKLNE--AKIKCEQLNLKAEQ--SKKELDKVVTTA 1346
Query: 415 QSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
+ V + E T D + +H+Q +E GT+ ++
Sbjct: 1347 IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE-----QNGTHFQE 1401
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
+ + + E+ E+N + + +V ++ + +E + Q ++ A ++ +I
Sbjct: 1402 GDGKSAIGEE--DEVNGNLLETDVDG---QVGTTQENLNQQYQKVKAQHEKIISQHQAVI 1456
Query: 535 LKLKQMQKTIDNFSK-VSDSNKE-IVRLTEELH-HLSQKVAELEEEKG---NLQLHLVDY 588
+ + Q ++ + +S KE + + +EL H +AE E++ +LQ L +
Sbjct: 1457 IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKF 1516
Query: 589 DSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D+ E + + E+ENL L+ K ++ K D ++
Sbjct: 1517 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1576
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
L++ + CS+ ++D SA+ +E+ +++ LY L N+ +D++
Sbjct: 1577 RVLEAAKSCSKRDG----GKVDT-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLV 1631
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY-IEN 766
+K Q+Y + L L+ A L I +D K +R L +
Sbjct: 1632 DKYQHYEDASCGLLAGLQACEATASKHLSEPI------------AVDPKNLQRQLEETKA 1679
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
++ ++S + + +L+++ V+ D R SL + + L + Y + + +E +
Sbjct: 1680 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 1739
Query: 827 LAVLMDHDRVVEKQLLEI----EHENKELQKKNQI---------LLEENQNLQISLSDMQ 873
L + + V+ L E+ + L+++ Q+ ++ +N L+ ++ Q
Sbjct: 1740 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 1799
Query: 874 QHYNALVEKANRTDLAESEST--KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI- 930
NA+ EK + ST Q +++DL + +H+H+ + + ++ +E+
Sbjct: 1800 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 1859
Query: 931 -EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ ++++ + K + + + VT+L +QE + ++E L+ + E+
Sbjct: 1860 ENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEIS 1919
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + T + ++ +K+K E + + ++++ QV +V +S
Sbjct: 1920 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV----LVKSLKSW 1975
Query: 1050 LAQFTTKLENMEEEM--QRVSKQLLDSKQHNEELQILVRE-QDDQIKELKETKLTFEMNI 1106
+ + T K+ ++ + + K L D+K+ E+ + E Q + L +
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2035
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT 1166
P + S ++ + + +K ++ ++ L
Sbjct: 2036 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIK----KDMTDISHGYEDLGLLLKD 2091
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND-NLLSTVAELRSSIS 1225
++ E TK+ +L+ E + + +++N+ +K +Q D + T E S
Sbjct: 2092 KIAELNTKLSKLQKAQEESSAM-MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFE 2150
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELR--VQLSAFESKYE---QLLDSVQSSTQ 1280
+ + Q ++ EL K L + + T R L+ +SK++ QL Q +
Sbjct: 2151 AELKQNVNKVQEL-KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2209
Query: 1281 EETNKIVTMEQV-TSLQNKLQDKE 1303
E +N + + V L+ L +KE
Sbjct: 2210 ESSNNLTQFQTVEAQLKQWLVEKE 2233
Score = 61.7 bits (143), Expect = 2e-08
Identities = 167/876 (19%), Positives = 359/876 (40%), Gaps = 83/876 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ-ITQLND--EIDAANKNMIKV 529
+++ + A+ +EQ + N I +V +++ +L++ E++ I Q+ E D ++++ ++
Sbjct: 723 QELLKSAEREEQEESVYNLYISEV--RNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 780
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL-QLHLVD- 587
KLK K++++ D+ +++ +E + +EL N+ Q++ +
Sbjct: 781 TEQEKLK-KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 839
Query: 588 -YDSGRMIESDVYKKMIEMENLA---ETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
Y + V K E L ET+L + + K ++ + L+Q EV++K
Sbjct: 840 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 899
Query: 644 LADISQLQSD-----QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ + + E+ + E +D K++ ++E + Q+ ++D
Sbjct: 900 RQVFHALEDELQKAKAISDEMFKTYKERDLD-FDWHKEKADQLVERWQNVHVQIDNRLRD 958
Query: 699 LENDKE------DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
LE + D + L ++IQ+ K+++ E L ++N ++ + +
Sbjct: 959 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1018
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKA 812
+K+ E Y E + + Y+ + + + R +QE
Sbjct: 1019 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1077
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+ YT + + D + +E++ +E E KE +K + L + N+ +L D
Sbjct: 1078 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDA 1137
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK-----KKEIED 927
++ K + +E STK + QL + ++ +H + + +K+++
Sbjct: 1138 EKAGKPPFSKQKIS--SEEISTK-KEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1194
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
L+ +N +++ + + +E E Q QEYK ++ + + L +
Sbjct: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQ-QEYKEKLQGI---CDLLTQTENR 1250
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
LI ++ D T E+ K + K EE L + + + + +V + E
Sbjct: 1251 LIG---HQEAFMIGDGTV----ELKK----YQSKQEE---LQKDMQGSAQALAEVVKNTE 1296
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM-NI 1106
+ L + KL +E+ + ++L ++K E+L + + ++ ++ T + E +
Sbjct: 1297 NFLKENGEKLS--QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKV 1354
Query: 1107 PKTEGMIISST-IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ--ERSVLQEQSAK 1163
+ + S T IE + D +NVD + Q F + +S + E+ +
Sbjct: 1355 AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEED-E 1413
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
+N L L T++ G QE +NQ + +++ +++ ++S + +
Sbjct: 1414 VNGNL------------LETDVDGQVGTTQENLNQ---QYQKVKAQHEKIISQHQAVIIA 1458
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
SA + E Q+L+ E + QK EL+V ++ E+ + + S QEE
Sbjct: 1459 TQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM-KLTHSLQEE 1512
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
K T ++ LQ E+ L NL E AD IN
Sbjct: 1513 LEKFDA--DYTEFEHWLQQSEQELENL-EAGADDIN 1545
Score = 59.3 bits (137), Expect = 1e-07
Identities = 176/886 (19%), Positives = 364/886 (41%), Gaps = 84/886 (9%)
Query: 471 NTEDVN-EIAKVQEQLKQE--LNDEIKDVNVKDLIE--------KLKSAEEQITQLNDEI 519
N E + + +K++EQ+ Q L D+I + N K L + K+ S+ E + ++
Sbjct: 3114 NCEPIGTQASKLEEQIAQHKALEDDIINHN-KHLHQAVSIGQSLKVLSSREDKDMVQSKL 3172
Query: 520 DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
D + I+++ + + +Q+ + N + E++ E+H K+++L +
Sbjct: 3173 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---DKLSKLSVQDY 3229
Query: 580 NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+ + R+++ D+ ++ +N+ + L + LL+ D E+ I+Q K +
Sbjct: 3230 STEGLWKQQSELRVLQEDI---LLRKQNVDQALLNGLELLKQTTGD---EVLIIQDKLEA 3283
Query: 640 VEDKLADISQLQSD---------QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
++ + DI++L +D Q+ + S H EE L + EL + +E
Sbjct: 3284 IKARYKDITKLSTDVAKTLEQALQLARRLHSTH-EELCTWLDKVEVELLSYETQVLKGEE 3342
Query: 691 QLYGTIKDLENDKEDIMNK--LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
++ E KE NK L + + + L + + + E + +++A+ N +
Sbjct: 3343 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSD 3402
Query: 749 TQFGIDAKIQERDLYI---ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
T I K++E D I + + S I E+ + + D R LE+ DQ +
Sbjct: 3403 T---ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR--LEQ--DQTSAQ 3455
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
LQ QK ++ ++ ++++ L V H + E E + ++KK +L+ +
Sbjct: 3456 LQ-VQKTFTMEILRHKDIIDDL-VKSGHKIMTACS----EEEKQSMKKKLDKVLKNYDTI 3509
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK--K 923
S+ N+ E + T+ + + S L E++TL Q++ +
Sbjct: 3510 CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHR 3569
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
++ +L E I+ +N+ + +E +QE + L ++E K
Sbjct: 3570 QLRELIAEHKPHIDK-------MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3622
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+D+ + Q TQ D +Q + + ++ L+Q I A +KI Q+S V
Sbjct: 3623 KRAVALDEAI-SQSTQFHDKIDQILESLERIVERLRQ-PPSISAEVEKIKE-QISENKNV 3679
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVS---KQLLDSKQHNEEL--QILVREQDDQIKELKET 1098
S KL L+ EEM S + + +K ++L + + E + E +E
Sbjct: 3680 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREA 3739
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVL 1157
KL M + + S I + D + + + QE E I+E L
Sbjct: 3740 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 3799
Query: 1158 QEQ---SAKLNTEL----QECYTKIIQ--LETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
QE+ L +EL E I++ ++ LN+ + +++I++L+ ++
Sbjct: 3800 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 3859
Query: 1209 ENDNLLSTV--AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
D L + ++ +++ G ++ E KQ + + + F+ ++ ++++
Sbjct: 3860 YQDGLQAVFDWVDIAGGKLASMSPIGTDL-ETVKQQIEELK-QFKSEAYQQQIEMERLNH 3917
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
+ E LL V EE++K + + L+ EE + N Q K
Sbjct: 3918 QAELLLKKV----TEESDKHTVQDPLMELKLIWDSLEERIINRQHK 3959
Score = 55.6 bits (128), Expect = 1e-06
Identities = 170/872 (19%), Positives = 355/872 (40%), Gaps = 111/872 (12%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE-NKLATMGT-- 354
+ I+ + + ++ E++ +TE KK+ L + + QT+ +L+ K TM
Sbjct: 3409 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3468
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
+ K G +++ S S K +L N DT +IN +LE
Sbjct: 3469 HKDIIDDLVKSGHKIMTACSEEEKQSMKK----KLDKVLKNYDTICQINSERYLQLERAQ 3524
Query: 415 QSLNKD----------LVDKEYVISEKDTXXXXXXXXXXGKDT--LIAQLQLEHQQHME- 461
+N+ L + + +IS+ ++ + +L EH+ H++
Sbjct: 3525 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3584
Query: 462 ----GPSLIHVGTNTEDVNEIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQL 515
GP L+ + E +QE+ L +IK+ +VK L A Q TQ
Sbjct: 3585 MNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKE-DVKKRAVALDEAISQSTQF 3638
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELE 575
+D+ID +++ ++ + + + ++ + NK + E+L L + + +
Sbjct: 3639 HDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 3697
Query: 576 EEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENL----AETRLKAISLLE-SQKF----- 624
EE + D D S + ++ + + + EN+ E K + ++E ++KF
Sbjct: 3698 EEM-IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 3756
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
L+ + Q ++ED D S ++ Q +E + E+ID L ++EL +VI N
Sbjct: 3757 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET----IREEIDGL---QEELDIVI-N 3808
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ 744
L + G E DK I+ K + + D +K K +K+ E + Q
Sbjct: 3809 LGSELIAACG-----EPDKP-IVKKSIDELNSAWDSLNKAWKDRIDKLEEAM-------Q 3855
Query: 745 SKIQTQFGIDAKIQERDLY------IENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q G+ A D+ + I ++L K +I L++ + ++ +ER
Sbjct: 3856 AAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 3915
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
Q L++ + ++T+Q D ++E +L+ E + + +++++
Sbjct: 3916 NHQAELLLKKVTEESDKHTVQ--------------DPLMELKLIWDSLEERIINRQHKL- 3960
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+ ++L Q + L+ T+ SE + +E L + H Q +
Sbjct: 3961 ----EGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HHVLQNDV 4015
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDK--------KVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + +E + N IES+ ++ +VLN++++ +E Q + QL
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075
Query: 971 IENLNMNVEELNKMNLELIDKHV--QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
+ + +E+L + L ++H+ K P+ ++ +N ++ A + K+E +L
Sbjct: 4076 AKGFHGEIEDLQQW-LTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4134
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
QK Q E+ + Q + N++E+ + V +L + K EE L E
Sbjct: 4135 MQK---GQQMLARCPKSAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEF 4188
Query: 1089 DDQIKELKE--TKLTFEMNIPKTEGMIISSTI 1118
+ +++ T+ +N+ +I+ + +
Sbjct: 4189 HNSLQDFINWLTQAEQTLNVASRPSLILDTVL 4220
Score = 44.8 bits (101), Expect = 0.003
Identities = 203/1055 (19%), Positives = 421/1055 (39%), Gaps = 111/1055 (10%)
Query: 298 QSIEPSCEEK-TEIEEKGSLEIANMTE---LTKKIELLEHLNCQIRQTNKELENKLATMG 353
QS+ S +K ++++ K S +A T + +++E + + +I+Q K+++ A
Sbjct: 2330 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2389
Query: 354 TESKAVSSPSKKGSPLISR------KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
S V K +SR KS ++ K ++ L S + ++++++
Sbjct: 2390 DLSALVKEEYLKAE--LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2447
Query: 408 AKLEMVIQSLNKDLVDKEYVISEK-DTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
A L+ K+ +K + IS K D TL AQ + + EG +L+
Sbjct: 2448 AWLDT-----KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2502
Query: 467 HVGTNTEDVNEIAKVQEQLK------QELNDEIKDVN--VKDLIEKLKSAEEQITQLNDE 518
T+ +E A +Q QL N ++K+ +K+ +EK +EQ+ L
Sbjct: 2503 ---LKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2558
Query: 519 IDAANKNMIKVK--------SNHKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQ 569
ID N+ ++K N KLK +QK +D +F V N L + + +
Sbjct: 2559 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDK 2617
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+V +E K +Q VD M+ ++ K +EN+ +QKF QE
Sbjct: 2618 EVV-TDENKSLIQ--KVD-----MVTEQLHSKKFCLENM------------TQKFKEFQE 2657
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL---VIENLK 686
+ ++ + + DI Q S L+ Q +L A K ++ L + ++L
Sbjct: 2658 VSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 2717
Query: 687 LDKEQLYGT---IKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS--AEKISELLAKI-N 740
++ GT + +E ++ Q ++ L KL+ + I E+ ++
Sbjct: 2718 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 2777
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+++ G DA+ ++ E I++ L K ++ + + + + + E D
Sbjct: 2778 FDDELDSMAPVGRDAETLQKQK--ETIKAFLKKLEALMASNDNANKTCKMMLATEETSPD 2835
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+G ++ +A S+ Q ++L++R + VE + +E +L K+ ILL+
Sbjct: 2836 LVG--IKRDLEALSK---QCNKLLDRAQA---REEQVEGTIKRLEEFYSKL-KEFSILLQ 2886
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ + + S + + ++ N + + E ++ L+ + + Q LI
Sbjct: 2887 KAEEHEESQGPVGMETETINQQLNMFKVFQKE------EIEPLQGKQQDVNWLGQGLIQS 2940
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL---NMN 977
K +E + ++ K LN+K + + + +++ +E+L ++
Sbjct: 2941 AAKSTSTQGLEHD--LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 2998
Query: 978 VEEL-NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
EEL + V K Q Q ++ +++ ++K++ E+I + + +
Sbjct: 2999 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD--K 3056
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
V + +S +S+ K E +++ +S + ++Q +E L+ L E I++
Sbjct: 3057 VKILKQLSLLDSRWEALLNKAETRNRQLEGIS---VVAQQFHETLEPL-NEWLTTIEKRL 3112
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV---QEEEEFIQE 1153
K E I + + DD N + LKV +E+++ +Q
Sbjct: 3113 VNCEPIGTQASKLEEQIAQH--KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3170
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDN 1212
+ + E ++++Q N ++ G D V +N++ KL +L+ ++
Sbjct: 3171 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD-- 3228
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
ST + V Q E L KQ++ Q + + + ++ + K E +
Sbjct: 3229 -YSTEGLWKQQSELRVLQ---EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3284
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+ T+ T+ T+EQ L +L E L
Sbjct: 3285 KARYKDITKLSTDVAKTLEQALQLARRLHSTHEEL 3319
>AL512448-2|CAI16608.1| 5457|Homo sapiens dystonin protein.
Length = 5457
Score = 81.0 bits (191), Expect = 3e-14
Identities = 263/1381 (19%), Positives = 561/1381 (40%), Gaps = 138/1381 (9%)
Query: 314 GSLEIANMTELTKKIELLEHLNC-QIRQTNKE---LENKLATMGTESKAVSSPSKKGSPL 369
G+ ++ E TKK++ L +I++ N L N ++ + T +KA+++ G+ L
Sbjct: 2317 GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVL 2376
Query: 370 ISRKSGRNTASKMKSPWSQLSSETLNQD-TDKK--------INKNEIAKLEMVIQSLNKD 420
+G TA+ + W+ ++ +D TD + K++IA+L + L K
Sbjct: 2377 ----NGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
Query: 421 LVDKEYV---ISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTEDVNE 477
+ + + + + DT + Q+E + E + N V E
Sbjct: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA----ELKQNVNKVQE 2488
Query: 478 IAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLN----DEIDAANKNMIK---VK 530
+ +L +E D + K ++ ++ S +++ QL +++ ++ N+ + V+
Sbjct: 2489 LKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVE 2548
Query: 531 SNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDS 590
+ K L + + + +S + +++ L Q+ A + + QL
Sbjct: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE--QLTAAGQGI 2606
Query: 591 GRMIESDVYKKMIEMENLAETRLKAISLLE--SQKFDLVQELHILQQKYDEV----EDKL 644
D + I E LA K SL S + D + + + +Y + DKL
Sbjct: 2607 LSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2666
Query: 645 ADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDK---EQLYGTIKDLEN 701
+D+ S + + +Q++ K+E+ + +K+ + E L +K+ E
Sbjct: 2667 SDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKE-EY 2725
Query: 702 DKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERD 761
K ++ +L+ ++ D+ K E + + A + +Q Q +D K +E++
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAEN-HVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
Query: 762 ------LYIENIESELSKYKSRICRL-------EESIAVMED---RRYSLERKADQLG-S 804
++ +ES + +K L E++IA E+ + E+ A QL +
Sbjct: 2785 KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2844
Query: 805 YLQEKQKAYSEYTIQ-EDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL-LEEN 862
++ +++ + E++L L + + VE I+ L++ L E
Sbjct: 2845 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2904
Query: 863 QN----LQISLSDMQQHYNALVEKANRT-----DLAESESTKYQTQLRDLESNLKRITHE 913
+N L+ +M QH+ +VE N T + E + + + L + +T +
Sbjct: 2905 ENSIAKLKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQ 2963
Query: 914 HQTL------IVQKKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEY 967
+ + QK KE +++ E Q++ A +++ +++ Y + LQ
Sbjct: 2964 LHSKKFCLENMTQKFKEFQEVSKESKRQLQCA-KEQLDIHDSLGSQA-YSNKYLTMLQTQ 3021
Query: 968 KNNIENLNMNVEELNKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIA 1027
+ +++ L V+ ++ +L+ + + T D Q + + L +Q DE+
Sbjct: 3022 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSF 3079
Query: 1028 LNQKINNAQVSYMSMVSDYESKLAQFTTKLENME---EEMQRVSKQLLDSKQHNEELQIL 1084
L K+ + + + + S+ A+F +L++M + + + KQ K ++L+ L
Sbjct: 3080 LETKLQGIG-HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3138
Query: 1085 VREQDDQIKELKETKLTFEMNIPKTEGMIISSTIEPMSDDANNV-DXXXXXXXXXXXXLK 1143
+ D+ K K T E + P G I +E +S N + D +K
Sbjct: 3139 MASNDNANKTCKMMLATEETS-PDLVG--IKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3195
Query: 1144 VQEE-EEFIQERSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSK 1202
EE ++E S+L Q A+ + E Q ++ ET+N +L V +E+I L+ K
Sbjct: 3196 RLEEFYSKLKEFSILL-QKAEEHEESQGPVG--METETINQQLNMFKVFQKEEIEPLQGK 3252
Query: 1203 LEQLNTENDNLLSTVAELRSSISSAVDQRGFEIAELWK---QHLAQREADFQKTEHELRV 1259
+ +N L+ + A +S+ + ++ ++ WK + +AQR A Q E +
Sbjct: 3253 QQDVNWLGQGLIQSAA--KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQ----EALL 3306
Query: 1260 QLSAFESKYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKE-EHLRNLQEKYADVIN 1318
F+ E LL S +T ++V ++ S + K+ + + + LQ D +
Sbjct: 3307 HCGRFQDALESLL-----SWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKS 3361
Query: 1319 QIEILRSEIEDEKVAFXXX-XXXXXXXXXXXXXDLRTENQSYK-QMQEQSILNINEENAQ 1376
+E+++ E EK+A D R E K + + + + I+ Q
Sbjct: 3362 TVEVIKR--EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3419
Query: 1377 LKKSSXXXXXXXXXXXXRVNDAE-----AKVLE--LTHQLELKDSEIYQKTHEYTITLTQ 1429
++ R+ + E A LE + L+D I H +
Sbjct: 3420 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3479
Query: 1430 RNDEFENVRQ--QLVEYEKRIEDLTYEKESELAILRLKMHENANHYETMQKESEIERVKL 1487
++ + + R+ +V+ + + Y + E + R ++ + A + E E+E +
Sbjct: 3480 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3539
Query: 1488 IEELNVKITE-------SVSLNKQVAELNKALEEEV--AKTNEMQTALENQEIEIVTLND 1538
+ E++ K+++ + L KQ +EL + L+E++ K N Q L E+ T D
Sbjct: 3540 LNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGD 3598
Query: 1539 EITNLQNMVRASSSKIQKHVSFASDTKQGRDEQLD-----NTMNKELLDAVPRAELDLAM 1593
E+ +Q+ + A ++ + ++D + ++ L ++ ++EL + + E++L
Sbjct: 3599 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLS 3658
Query: 1594 Y 1594
Y
Sbjct: 3659 Y 3659
Score = 67.3 bits (157), Expect = 4e-10
Identities = 176/873 (20%), Positives = 365/873 (41%), Gaps = 99/873 (11%)
Query: 501 LIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSK-VSDSNKE--- 556
+ + +K A + + +L +E K++ + K H K K++QK + N SK + D+ K
Sbjct: 1414 MTQYIKFAGDSLKRLEEE----EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKP 1469
Query: 557 -IVRLTEELHHLSQKVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKA 615
+ +S K +L E +QL L + +M + + + +++ L E+
Sbjct: 1470 PFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD-KMTDEERNELEKQVKTLQESYNLL 1528
Query: 616 IS-----LLESQKF-DLVQELHILQQKYDEVEDKLADISQLQS---DQVCSEIKSVHLEE 666
S L ESQ D+ E I+ ++ E ++KL I L + +++ ++ + +
Sbjct: 1529 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1588
Query: 667 QIDALSASKKELALVIENLKLDKEQLYGTIKDLEN------------DKEDIMNKLQNY- 713
L + + + ++++ + L +K+ EN DK I KL
Sbjct: 1589 GTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAK 1648
Query: 714 IQ-ENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLYIENIE--SE 770
I+ E ++L + K +K+ K E+ + ++ KI+ ++ N++ SE
Sbjct: 1649 IKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE 1708
Query: 771 LSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNRLAVL 830
+ K + + E S + D++ L E T QE+ V
Sbjct: 1709 RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVK 1768
Query: 831 MDHDRVVEK-QLLEIEHENKE--LQKKNQILL-EENQNLQISLSDMQQHYN-ALVEKANR 885
H++++ + Q + I ++ + L+K+ Q L EE + LQ ++ +++ HY AL E +
Sbjct: 1769 AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKK 1828
Query: 886 TDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI---EFNTQIESAIRD 942
L S Q +L +++ H Q Q ++E+E+LE + N + R
Sbjct: 1829 MKLTHS----LQEELEKFDADYTEFEHWLQ----QSEQELENLEAGADDINGLMTKLKRQ 1880
Query: 943 KKVLNE--KYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELIDKHVQKQQTQS 1000
K + ++ ++ Y+T ++ E + + K++ + VQ++ +
Sbjct: 1881 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSK-----RDGGKVDTSATHREVQRKLDHA 1935
Query: 1001 PDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESKLAQFTTKLENM 1060
D ++ N L LK +++ Q +A ++ + E+ ++ + E +
Sbjct: 1936 TDRFRSLYSKCNVLGNNLK----DLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPI 1989
Query: 1061 EEEMQRVSKQLLDSKQHNEEL---QILVREQDDQIKELKETK---LTFEMNIPKTEGMII 1114
+ + + +QL ++K ++ Q+ V + + L + + L + +I KT I+
Sbjct: 1990 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2049
Query: 1115 SSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEE-EEFIQ-----ERSVLQEQSAKLN-TE 1167
E +S N + L VQ+ +E + E S+ ++ LN T
Sbjct: 2050 GR-YEDLSKSVN--ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2106
Query: 1168 LQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSSISSA 1227
LQ+ +K I LE ++ G Q IN + K+++ D ST + L++ +
Sbjct: 2107 LQDIISKNIMLEQ---DIAGR----QSSINAMNEKVKKFMETTDP--STASSLQAKMKD- 2156
Query: 1228 VDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFESKYEQLLDSVQSSTQEETNKIV 1287
+ R E + K+ LA+ E EL+ ++ FE+ E+L +++ TQ T V
Sbjct: 2157 LSARFSEASHKHKETLAKME--------ELKTKVELFENLSEKLQTFLETKTQALTEVDV 2208
Query: 1288 TMEQVTSLQNKLQDKEEHLRNLQEKYADVINQI 1320
+ VT L +Q+ +K+ +V++ +
Sbjct: 2209 PGKDVTELSQYMQESTSEFLE-HKKHLEVLHSL 2240
Score = 62.5 bits (145), Expect = 1e-08
Identities = 179/1044 (17%), Positives = 417/1044 (39%), Gaps = 81/1044 (7%)
Query: 297 KQSIEPSCEEKTEIEEK--GSLEIANMTELTKKIELLEHLNCQIRQTNKELENKLATMGT 354
K+ ++ C+ T+ E + G E + + T +EL ++ + Q + K+++ +
Sbjct: 1560 KEKLQGICDLLTQTENRLIGHQEAFMIGDGT--VELKKYQSKQ-EELQKDMQGSAQALAE 1616
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
K + K+ +S++ K+ +++ E LN ++ +K E+ K+
Sbjct: 1617 VVKNTENFLKENGEKLSQEDKALIEQKLNE--AKIKCEQLNLKAEQ--SKKELDKVVTTA 1672
Query: 415 QSLNKDLVDKEYVISEKDTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLIHVGTNTED 474
+ V + E T D + +H+Q +E GT+ ++
Sbjct: 1673 IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE-----QNGTHFQE 1727
Query: 475 VNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQITQLNDEIDAANKNMIKVKSNHK 534
+ + + E+ E+N + + +V ++ + +E + Q ++ A ++ +I
Sbjct: 1728 GDGKSAIGEE--DEVNGNLLETDVDG---QVGTTQENLNQQYQKVKAQHEKIISQHQAVI 1782
Query: 535 LKLKQMQKTIDNFSK-VSDSNKE-IVRLTEELH-HLSQKVAELEEEKG---NLQLHLVDY 588
+ + Q ++ + +S KE + + +EL H +AE E++ +LQ L +
Sbjct: 1783 IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKF 1842
Query: 589 DSGRM-IESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDEVEDKLADI 647
D+ E + + E+ENL L+ K ++ K D ++
Sbjct: 1843 DADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGN 1902
Query: 648 SQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKDLENDKEDIM 707
L++ + CS+ ++D SA+ +E+ +++ LY L N+ +D++
Sbjct: 1903 RVLEAAKSCSKRDG----GKVDT-SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLV 1957
Query: 708 NKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFGIDAKIQERDLY-IEN 766
+K Q+Y + L L+ A L I +D K +R L +
Sbjct: 1958 DKYQHYEDASCGLLAGLQACEATASKHLSEPI------------AVDPKNLQRQLEETKA 2005
Query: 767 IESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKAYSEYTIQEDELVNR 826
++ ++S + + +L+++ V+ D R SL + + L + Y + + +E +
Sbjct: 2006 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2065
Query: 827 LAVLMDHDRVVEKQLLEI----EHENKELQKKNQI---------LLEENQNLQISLSDMQ 873
L + + V+ L E+ + L+++ Q+ ++ +N L+ ++ Q
Sbjct: 2066 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2125
Query: 874 QHYNALVEKANRTDLAESEST--KYQTQLRDLESNLKRITHEHQTLIVQKKKEIEDLEI- 930
NA+ EK + ST Q +++DL + +H+H+ + + ++ +E+
Sbjct: 2126 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2185
Query: 931 -EFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLELI 989
+ ++++ + K + + + VT+L +QE + ++E L+ + E+
Sbjct: 2186 ENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEIS 2245
Query: 990 DKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYESK 1049
+ + + T + ++ +K+K E + + ++++ QV +V +S
Sbjct: 2246 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV----LVKSLKSW 2301
Query: 1050 LAQFTTKLENMEEEM--QRVSKQLLDSKQHNEELQILVRE-QDDQIKELKETKLTFEMNI 1106
+ + T K+ ++ + + K L D+K+ E+ + E Q + L +
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2361
Query: 1107 PKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQERSVLQEQSAKLNT 1166
P + S ++ + + +K ++ ++ L
Sbjct: 2362 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIK----KDMTDISHGYEDLGLLLKD 2417
Query: 1167 ELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTEND-NLLSTVAELRSSIS 1225
++ E TK+ +L+ E + + +++N+ +K +Q D + T E S
Sbjct: 2418 KIAELNTKLSKLQKAQEESSAM-MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFE 2476
Query: 1226 SAVDQRGFEIAELWKQHLAQREADFQKTEHELR--VQLSAFESKYE---QLLDSVQSSTQ 1280
+ + Q ++ EL K L + + T R L+ +SK++ QL Q +
Sbjct: 2477 AELKQNVNKVQEL-KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLE 2535
Query: 1281 EETNKIVTMEQV-TSLQNKLQDKE 1303
E +N + + V L+ L +KE
Sbjct: 2536 ESSNNLTQFQTVEAQLKQWLVEKE 2559
Score = 61.7 bits (143), Expect = 2e-08
Identities = 167/876 (19%), Positives = 359/876 (40%), Gaps = 83/876 (9%)
Query: 473 EDVNEIAKVQEQLKQELNDEIKDVNVKDLIEKLKSAEEQ-ITQLND--EIDAANKNMIKV 529
+++ + A+ +EQ + N I +V +++ +L++ E++ I Q+ E D ++++ ++
Sbjct: 1049 QELLKSAEREEQEESVYNLYISEV--RNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI 1106
Query: 530 KSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKGNL-QLHLVD- 587
KLK K++++ D+ +++ +E + +EL N+ Q++ +
Sbjct: 1107 TEQEKLK-KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1165
Query: 588 -YDSGRMIESDVYKKMIEMENLA---ETRLKAISLLESQKFDLVQELHILQQKYDEVEDK 643
Y + V K E L ET+L + + K ++ + L+Q EV++K
Sbjct: 1166 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEK 1225
Query: 644 LADISQLQSD-----QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKEQLYGTIKD 698
L+ + + E+ + E +D K++ ++E + Q+ ++D
Sbjct: 1226 RQVFHALEDELQKAKAISDEMFKTYKERDLD-FDWHKEKADQLVERWQNVHVQIDNRLRD 1284
Query: 699 LENDKE------DIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQTQFG 752
LE + D + L ++IQ+ K+++ E L ++N ++ + +
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1344
Query: 753 IDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSYLQEKQKA 812
+K+ E Y E + + Y+ + + + R +QE
Sbjct: 1345 -QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1403
Query: 813 YSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNLQISLSDM 872
+ YT + + D + +E++ +E E KE +K + L + N+ +L D
Sbjct: 1404 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDA 1463
Query: 873 QQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQK-----KKEIED 927
++ K + +E STK + QL + ++ +H + + +K+++
Sbjct: 1464 EKAGKPPFSKQKIS--SEEISTK-KEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1520
Query: 928 LEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNKMNLE 987
L+ +N +++ + + +E E Q QEYK ++ + + L +
Sbjct: 1521 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQ-QEYKEKLQGI---CDLLTQTENR 1576
Query: 988 LIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMVSDYE 1047
LI ++ D T E+ K + K EE L + + + + +V + E
Sbjct: 1577 LIG---HQEAFMIGDGTV----ELKK----YQSKQEE---LQKDMQGSAQALAEVVKNTE 1622
Query: 1048 SKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELKETKLTFEM-NI 1106
+ L + KL +E+ + ++L ++K E+L + + ++ ++ T + E +
Sbjct: 1623 NFLKENGEKLS--QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKV 1680
Query: 1107 PKTEGMIISST-IEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQ--ERSVLQEQSAK 1163
+ + S T IE + D +NVD + Q F + +S + E+ +
Sbjct: 1681 AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEED-E 1739
Query: 1164 LNTELQECYTKIIQLETLNTELTGHDVVNQEQINQLKSKLEQLNTENDNLLSTVAELRSS 1223
+N L L T++ G QE +NQ + +++ +++ ++S + +
Sbjct: 1740 VNGNL------------LETDVDGQVGTTQENLNQ---QYQKVKAQHEKIISQHQAVIIA 1784
Query: 1224 ISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQLLDSVQSSTQEE 1282
SA + E Q+L+ E + QK EL+V ++ E+ + + S QEE
Sbjct: 1785 TQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM-KLTHSLQEE 1838
Query: 1283 TNKIVTMEQVTSLQNKLQDKEEHLRNLQEKYADVIN 1318
K T ++ LQ E+ L NL E AD IN
Sbjct: 1839 LEKFDA--DYTEFEHWLQQSEQELENL-EAGADDIN 1871
Score = 59.3 bits (137), Expect = 1e-07
Identities = 176/886 (19%), Positives = 364/886 (41%), Gaps = 84/886 (9%)
Query: 471 NTEDVN-EIAKVQEQLKQE--LNDEIKDVNVKDLIE--------KLKSAEEQITQLNDEI 519
N E + + +K++EQ+ Q L D+I + N K L + K+ S+ E + ++
Sbjct: 3440 NCEPIGTQASKLEEQIAQHKALEDDIINHN-KHLHQAVSIGQSLKVLSSREDKDMVQSKL 3498
Query: 520 DAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELEEEKG 579
D + I+++ + + +Q+ + N + E++ E+H K+++L +
Sbjct: 3499 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---DKLSKLSVQDY 3555
Query: 580 NLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQELHILQQKYDE 639
+ + R+++ D+ ++ +N+ + L + LL+ D E+ I+Q K +
Sbjct: 3556 STEGLWKQQSELRVLQEDI---LLRKQNVDQALLNGLELLKQTTGD---EVLIIQDKLEA 3609
Query: 640 VEDKLADISQLQSD---------QVCSEIKSVHLEEQIDALSASKKELALVIENLKLDKE 690
++ + DI++L +D Q+ + S H EE L + EL + +E
Sbjct: 3610 IKARYKDITKLSTDVAKTLEQALQLARRLHSTH-EELCTWLDKVEVELLSYETQVLKGEE 3668
Query: 691 QLYGTIKDLENDKEDIMNK--LQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQSKIQ 748
++ E KE NK L + + + L + + + E + +++A+ N +
Sbjct: 3669 ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSD 3728
Query: 749 TQFGIDAKIQERDLYI---ENIESELSKYKSRICRLEESIAVMEDRRYSLERKADQLGSY 805
T I K++E D I + + S I E+ + + D R LE+ DQ +
Sbjct: 3729 T---ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR--LEQ--DQTSAQ 3781
Query: 806 LQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLEENQNL 865
LQ QK ++ ++ ++++ L V H + E E + ++KK +L+ +
Sbjct: 3782 LQ-VQKTFTMEILRHKDIIDDL-VKSGHKIMTACS----EEEKQSMKKKLDKVLKNYDTI 3835
Query: 866 QISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQKK--K 923
S+ N+ E + T+ + + S L E++TL Q++ +
Sbjct: 3836 CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHR 3895
Query: 924 EIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENLNMNVEELNK 983
++ +L E I+ +N+ + +E +QE + L ++E K
Sbjct: 3896 QLRELIAEHKPHIDK-------MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3948
Query: 984 MNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQVSYMSMV 1043
+D+ + Q TQ D +Q + + ++ L+Q I A +KI Q+S V
Sbjct: 3949 KRAVALDEAI-SQSTQFHDKIDQILESLERIVERLRQ-PPSISAEVEKIKE-QISENKNV 4005
Query: 1044 SDYESKLAQFTTKLENMEEEMQRVS---KQLLDSKQHNEEL--QILVREQDDQIKELKET 1098
S KL L+ EEM S + + +K ++L + + E + E +E
Sbjct: 4006 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREA 4065
Query: 1099 KLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKVQEEEEFIQER-SVL 1157
KL M + + S I + D + + + QE E I+E L
Sbjct: 4066 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4125
Query: 1158 QEQ---SAKLNTEL----QECYTKIIQ--LETLNTELTGHDVVNQEQINQLKSKLEQLNT 1208
QE+ L +EL E I++ ++ LN+ + +++I++L+ ++
Sbjct: 4126 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4185
Query: 1209 ENDNLLSTV--AELRSSISSAVDQRGFEIAELWKQHLAQREADFQKTEHELRVQLSAFES 1266
D L + ++ +++ G ++ E KQ + + + F+ ++ ++++
Sbjct: 4186 YQDGLQAVFDWVDIAGGKLASMSPIGTDL-ETVKQQIEELK-QFKSEAYQQQIEMERLNH 4243
Query: 1267 KYEQLLDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHLRNLQEK 1312
+ E LL V EE++K + + L+ EE + N Q K
Sbjct: 4244 QAELLLKKV----TEESDKHTVQDPLMELKLIWDSLEERIINRQHK 4285
Score = 55.6 bits (128), Expect = 1e-06
Identities = 170/872 (19%), Positives = 355/872 (40%), Gaps = 111/872 (12%)
Query: 298 QSIEPSCEEKTEIEEKGSLEIANMTELTKKIELLEHLNCQIRQTNKELE-NKLATMGT-- 354
+ I+ + + ++ E++ +TE KK+ L + + QT+ +L+ K TM
Sbjct: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
Query: 355 ESKAVSSPSKKGSPLISRKSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEIAKLEMVI 414
+ K G +++ S S K +L N DT +IN +LE
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKK----KLDKVLKNYDTICQINSERYLQLERAQ 3850
Query: 415 QSLNKD----------LVDKEYVISEKDTXXXXXXXXXXGKDT--LIAQLQLEHQQHME- 461
+N+ L + + +IS+ ++ + +L EH+ H++
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3910
Query: 462 ----GPSLIHVGTNTEDVNEIAKVQEQL--KQELNDEIKDVNVKDLIEKLKSAEEQITQL 515
GP L+ + E +QE+ L +IK+ +VK L A Q TQ
Sbjct: 3911 MNKTGPQLLELSPG-----EGFSIQEKYVAADTLYSQIKE-DVKKRAVALDEAISQSTQF 3964
Query: 516 NDEIDAANKNMIKVKSNHKLKLKQMQKTIDNFSKVSDSNKEIVRLTEELHHLSQKVAELE 575
+D+ID +++ ++ + + + ++ + NK + E+L L + + +
Sbjct: 3965 HDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4023
Query: 576 EEKGNLQLHLVDYD-SGRMIESDVYKKMIEMENL----AETRLKAISLLE-SQKF----- 624
EE + D D S + ++ + + + EN+ E K + ++E ++KF
Sbjct: 4024 EEM-IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4082
Query: 625 DLVQELHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELALVIEN 684
L+ + Q ++ED D S ++ Q +E + E+ID L ++EL +VI N
Sbjct: 4083 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET----IREEIDGL---QEELDIVI-N 4134
Query: 685 LKLDKEQLYGTIKDLENDKEDIMNKLQNYIQENMDLTDKLEKMSAEKISELLAKINHEEQ 744
L + G E DK I+ K + + D +K K +K+ E + Q
Sbjct: 4135 LGSELIAACG-----EPDKP-IVKKSIDELNSAWDSLNKAWKDRIDKLEEAM-------Q 4181
Query: 745 SKIQTQFGIDAKIQERDLY------IENIESELSKYKSRICRLEESIAVMEDRRYSLERK 798
+ +Q Q G+ A D+ + I ++L K +I L++ + ++ +ER
Sbjct: 4182 AAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4241
Query: 799 ADQLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQIL 858
Q L++ + ++T+Q D ++E +L+ E + + +++++
Sbjct: 4242 NHQAELLLKKVTEESDKHTVQ--------------DPLMELKLIWDSLEERIINRQHKL- 4286
Query: 859 LEENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLI 918
+ ++L Q + L+ T+ SE + +E L + H Q +
Sbjct: 4287 ----EGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HHVLQNDV 4341
Query: 919 VQKKKEIEDLEIEFNTQIESAIRDK--------KVLNEKYEKNIEYVTQLEAQLQEYKNN 970
+ + +E + N IES+ ++ +VLN++++ +E Q + QL
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 971 IENLNMNVEELNKMNLELIDKHV--QKQQTQSPDYTEQYINEINKLNALLKQKDEEIIAL 1028
+ + +E+L + L ++H+ K P+ ++ +N ++ A + K+E +L
Sbjct: 4402 AKGFHGEIEDLQQW-LTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4460
Query: 1029 NQKINNAQVSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQ 1088
QK Q E+ + Q + N++E+ + V +L + K EE L E
Sbjct: 4461 MQK---GQQMLARCPKSAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEF 4514
Query: 1089 DDQIKELKE--TKLTFEMNIPKTEGMIISSTI 1118
+ +++ T+ +N+ +I+ + +
Sbjct: 4515 HNSLQDFINWLTQAEQTLNVASRPSLILDTVL 4546
Score = 44.8 bits (101), Expect = 0.003
Identities = 203/1055 (19%), Positives = 421/1055 (39%), Gaps = 111/1055 (10%)
Query: 298 QSIEPSCEEK-TEIEEKGSLEIANMTE---LTKKIELLEHLNCQIRQTNKELENKLATMG 353
QS+ S +K ++++ K S +A T + +++E + + +I+Q K+++ A
Sbjct: 2656 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2715
Query: 354 TESKAVSSPSKKGSPLISR------KSGRNTASKMKSPWSQLSSETLNQDTDKKINKNEI 407
S V K +SR KS ++ K ++ L S + ++++++
Sbjct: 2716 DLSALVKEEYLKAE--LSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2773
Query: 408 AKLEMVIQSLNKDLVDKEYVISEK-DTXXXXXXXXXXGKDTLIAQLQLEHQQHMEGPSLI 466
A L+ K+ +K + IS K D TL AQ + + EG +L+
Sbjct: 2774 AWLDT-----KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
Query: 467 HVGTNTEDVNEIAKVQEQLK------QELNDEIKDVN--VKDLIEKLKSAEEQITQLNDE 518
T+ +E A +Q QL N ++K+ +K+ +EK +EQ+ L
Sbjct: 2829 ---LKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
Query: 519 IDAANKNMIKVK--------SNHKLKLKQMQKTID-NFSKVSDSNKEIVRLTEELHHLSQ 569
ID N+ ++K N KLK +QK +D +F V N L + + +
Sbjct: 2885 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDK 2943
Query: 570 KVAELEEEKGNLQLHLVDYDSGRMIESDVYKKMIEMENLAETRLKAISLLESQKFDLVQE 629
+V +E K +Q VD M+ ++ K +EN+ +QKF QE
Sbjct: 2944 EVV-TDENKSLIQ--KVD-----MVTEQLHSKKFCLENM------------TQKFKEFQE 2983
Query: 630 LHILQQKYDEVEDKLADISQLQSDQVCSEIKSVHLEEQIDALSASKKELAL---VIENLK 686
+ ++ + + DI Q S L+ Q +L A K ++ L + ++L
Sbjct: 2984 VSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV 3043
Query: 687 LDKEQLYGT---IKDLENDKEDIMNKLQNYIQENMDLTDKLEKMS--AEKISELLAKI-N 740
++ GT + +E ++ Q ++ L KL+ + I E+ ++
Sbjct: 3044 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3103
Query: 741 HEEQSKIQTQFGIDAKIQERDLYIENIESELSKYKSRICRLEESIAVMEDRRYSLERKAD 800
+++ G DA+ ++ E I++ L K ++ + + + + + E D
Sbjct: 3104 FDDELDSMAPVGRDAETLQKQK--ETIKAFLKKLEALMASNDNANKTCKMMLATEETSPD 3161
Query: 801 QLGSYLQEKQKAYSEYTIQEDELVNRLAVLMDHDRVVEKQLLEIEHENKELQKKNQILLE 860
+G ++ +A S+ Q ++L++R + VE + +E +L K+ ILL+
Sbjct: 3162 LVG--IKRDLEALSK---QCNKLLDRAQA---REEQVEGTIKRLEEFYSKL-KEFSILLQ 3212
Query: 861 ENQNLQISLSDMQQHYNALVEKANRTDLAESESTKYQTQLRDLESNLKRITHEHQTLIVQ 920
+ + + S + + ++ N + + E ++ L+ + + Q LI
Sbjct: 3213 KAEEHEESQGPVGMETETINQQLNMFKVFQKE------EIEPLQGKQQDVNWLGQGLIQS 3266
Query: 921 KKKEIEDLEIEFNTQIESAIRDKKVLNEKYEKNIEYVTQLEAQLQEYKNNIENL---NMN 977
K +E + ++ K LN+K + + + +++ +E+L ++
Sbjct: 3267 AAKSTSTQGLEHD--LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
Query: 978 VEEL-NKMNLELIDKHVQKQQTQSPDYTEQYINEINKLNALLKQKDEEIIALNQKINNAQ 1036
EEL + V K Q Q ++ +++ ++K++ E+I + + +
Sbjct: 3325 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD--K 3382
Query: 1037 VSYMSMVSDYESKLAQFTTKLENMEEEMQRVSKQLLDSKQHNEELQILVREQDDQIKELK 1096
V + +S +S+ K E +++ +S + ++Q +E L+ L E I++
Sbjct: 3383 VKILKQLSLLDSRWEALLNKAETRNRQLEGIS---VVAQQFHETLEPL-NEWLTTIEKRL 3438
Query: 1097 ETKLTFEMNIPKTEGMIISSTIEPMSDDANNVDXXXXXXXXXXXXLKV---QEEEEFIQE 1153
K E I + + DD N + LKV +E+++ +Q
Sbjct: 3439 VNCEPIGTQASKLEEQIAQH--KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3496
Query: 1154 RSVLQEQSAKLNTELQECYTKIIQLETLNTELTGHDVVN-QEQINQLKSKLEQLNTENDN 1212
+ + E ++++Q N ++ G D V +N++ KL +L+ ++
Sbjct: 3497 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD-- 3554
Query: 1213 LLSTVAELRSSISSAVDQRGFEIAELWKQHLAQREAD-FQKTEHELRVQLSAFESKYEQL 1271
ST + V Q E L KQ++ Q + + + ++ + K E +
Sbjct: 3555 -YSTEGLWKQQSELRVLQ---EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3610
Query: 1272 LDSVQSSTQEETNKIVTMEQVTSLQNKLQDKEEHL 1306
+ T+ T+ T+EQ L +L E L
Sbjct: 3611 KARYKDITKLSTDVAKTLEQALQLARRLHSTHEEL 3645
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.307 0.124 0.316
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 168,866,301
Number of Sequences: 224733
Number of extensions: 6362263
Number of successful extensions: 73268
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 522
Number of HSP's successfully gapped in prelim test: 2673
Number of HSP's that attempted gapping in prelim test: 36734
Number of HSP's gapped (non-prelim): 21774
length of query: 1630
length of database: 73,234,838
effective HSP length: 100
effective length of query: 1530
effective length of database: 50,761,538
effective search space: 77665153140
effective search space used: 77665153140
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.6 bits)
S2: 72 (33.1 bits)
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