Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000864-TA|BGIBMGA000864-PA|IPR007420|Protein of unknown
function DUF465
(1109 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein. 113 4e-24
L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated prote... 113 4e-24
X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (... 109 4e-23
M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain p... 108 1e-22
M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain p... 108 1e-22
Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein. 107 2e-22
EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7, ... 107 2e-22
D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heav... 107 2e-22
BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7, ... 107 2e-22
BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7, ... 107 2e-22
AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypepti... 107 2e-22
X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy... 107 3e-22
AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antige... 107 3e-22
BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6, ... 106 5e-22
AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain... 105 9e-22
Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heav... 104 2e-21
AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein p... 102 6e-21
AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb ... 100 6e-20
AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein. 100 6e-20
D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heav... 99 8e-20
BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,... 99 8e-20
BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,... 99 8e-20
AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin he... 99 8e-20
AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin he... 99 8e-20
AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain prot... 99 8e-20
AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY... 99 8e-20
AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein. 99 8e-20
X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain ... 95 2e-18
BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2, ... 95 2e-18
AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa ... 95 2e-18
AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/... 94 3e-18
Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein. 93 5e-18
AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related... 92 9e-18
M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein. 91 2e-17
M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy ch... 91 2e-17
BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,... 91 2e-17
AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein p... 91 2e-17
X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin he... 91 2e-17
BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1, ... 91 2e-17
Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein. 91 3e-17
X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mR... 91 3e-17
X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 ... 91 3e-17
BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,... 91 3e-17
X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy ch... 90 4e-17
AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein. 90 4e-17
AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein. 90 4e-17
X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for ... 90 5e-17
AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein ... 89 8e-17
AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein ... 89 8e-17
AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome assoc... 89 8e-17
Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9, no... 89 1e-16
M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle... 89 1e-16
CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein. 89 1e-16
AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy... 89 1e-16
X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein. 88 2e-16
U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein. 88 2e-16
U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protei... 88 2e-16
BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein pr... 87 2e-16
AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 prot... 87 2e-16
AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein ... 87 2e-16
AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein ... 87 2e-16
U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein. 87 3e-16
U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein. 87 3e-16
AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F, 3... 87 3e-16
AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F, 3... 87 3e-16
X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein. 85 1e-15
X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein. 85 1e-15
AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter r... 85 1e-15
AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter r... 85 1e-15
U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein. 84 2e-15
Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated microtub... 83 5e-15
AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein ... 83 7e-15
AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin he... 83 7e-15
AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin he... 83 7e-15
AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain cont... 81 2e-14
AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain cont... 81 2e-14
AK024959-1|BAB15043.1| 696|Homo sapiens protein ( Homo sapiens ... 81 2e-14
AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical rhabdomyos... 80 4e-14
AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,... 80 4e-14
AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,... 80 4e-14
BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein. 80 5e-14
AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein. 80 5e-14
AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein. 80 5e-14
AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein. 80 5e-14
AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110... 79 7e-14
AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110... 79 7e-14
AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein. 79 7e-14
AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein. 79 7e-14
AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein. 79 7e-14
AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein. 78 2e-13
BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein. 78 2e-13
BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein. 78 2e-13
AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein... 78 2e-13
AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein. 78 2e-13
AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein. 78 2e-13
AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransfera... 77 4e-13
AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated pr... 77 4e-13
AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golg... 77 4e-13
M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protei... 76 6e-13
AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein. 76 6e-13
U93121-1|AAB88727.1| 753|Homo sapiens M-phase phosphoprotein-1 ... 76 8e-13
X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa pro... 75 1e-12
BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex pr... 75 1e-12
BC060769-1|AAH60769.2| 1107|Homo sapiens chromosome 6 open readi... 75 1e-12
AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex pr... 75 1e-12
AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex pr... 75 1e-12
AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a varian... 75 1e-12
AL365275-1|CAI40383.1| 1140|Homo sapiens chromosome 6 open readi... 75 2e-12
AL137009-1|CAI20344.1| 1140|Homo sapiens chromosome 6 open readi... 75 2e-12
AL132874-2|CAI42604.1| 1140|Homo sapiens chromosome 6 open readi... 75 2e-12
AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein. 75 2e-12
AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110... 74 2e-12
X64838-1|CAA46050.1| 1427|Homo sapiens restin protein. 74 3e-12
BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein. 74 3e-12
D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 prot... 73 4e-12
BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containi... 73 4e-12
AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens ... 73 4e-12
L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein. 73 6e-12
D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein. 73 6e-12
BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein. 73 8e-12
AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-... 73 8e-12
BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 72 1e-11
BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 72 1e-11
AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein. 72 1e-11
AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein. 71 2e-11
AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex pr... 71 2e-11
X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal ... 71 2e-11
M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein. 71 2e-11
AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250... 71 2e-11
AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein. 71 2e-11
AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associ... 71 2e-11
BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein. 71 3e-11
BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein. 71 3e-11
BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein. 71 3e-11
AY739715-1|AAW65984.1| 617|Homo sapiens M-phase phosphoprotein ... 71 3e-11
AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein. 69 7e-11
AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein pr... 69 9e-11
U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein. 69 1e-10
BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with ... 69 1e-10
BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with ... 69 1e-10
AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens ... 69 1e-10
AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein. 69 1e-10
AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein. 69 1e-10
DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein. 68 2e-10
BX537964-1|CAD97928.1| 898|Homo sapiens hypothetical protein pr... 67 3e-10
BC105632-1|AAI05633.1| 898|Homo sapiens chromosome 10 open read... 67 3e-10
BC103499-1|AAI03500.1| 898|Homo sapiens chromosome 10 open read... 67 3e-10
BC100670-1|AAI00671.1| 1004|Homo sapiens C10orf118 protein protein. 67 3e-10
X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac m... 66 5e-10
BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein. 66 5e-10
BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for IM... 66 5e-10
AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein. 66 5e-10
AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment e... 66 5e-10
AB111886-1|BAC98374.1| 1571|Homo sapiens KIAA2034 protein protein. 66 7e-10
M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy cha... 66 9e-10
AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antige... 66 9e-10
AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein. 66 9e-10
J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplak... 65 1e-09
BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-... 65 1e-09
BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 1... 65 1e-09
BC028423-1|AAH28423.1| 1022|Homo sapiens PMFBP1 protein protein. 65 1e-09
AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein. 65 1e-09
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 65 1e-09
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 65 2e-09
AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein. 65 2e-09
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 65 2e-09
BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein. 64 2e-09
AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protei... 64 2e-09
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 64 2e-09
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 64 2e-09
AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protei... 64 2e-09
AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protei... 64 2e-09
AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protei... 64 2e-09
AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protei... 64 2e-09
AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring prot... 64 2e-09
AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein. 64 2e-09
BC051733-1|AAH51733.1| 1026|Homo sapiens LUZP1 protein protein. 64 3e-09
AL031428-1|CAI19705.1| 1026|Homo sapiens leucine zipper protein ... 64 3e-09
AK074153-1|BAB84979.1| 1046|Homo sapiens FLJ00226 protein protein. 64 3e-09
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 64 4e-09
AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting cit... 64 4e-09
BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein. 63 5e-09
BC050555-1|AAH50555.1| 873|Homo sapiens KTN1 protein protein. 63 5e-09
BC050281-1|AAH50281.1| 1011|Homo sapiens PPFIBP1 protein protein. 63 5e-09
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 63 5e-09
AB033056-1|BAA86544.2| 932|Homo sapiens KIAA1230 protein protein. 63 5e-09
BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/C... 62 8e-09
BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein. 62 8e-09
AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein. 62 8e-09
U53445-1|AAA98972.1| 752|Homo sapiens DOC1 protein. 62 1e-08
AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens ... 62 1e-08
AF273054-1|AAM44457.1| 613|Homo sapiens CTCL tumor antigen HD-C... 62 1e-08
Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50 p... 62 1e-08
M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain beta-s... 62 1e-08
BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting p... 62 1e-08
AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein. 62 1e-08
AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein. 62 1e-08
Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein. 61 2e-08
X04201-1|CAA27798.1| 285|Homo sapiens protein ( Human skeletal ... 61 2e-08
D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein. 61 2e-08
BC117174-1|AAI17175.1| 1291|Homo sapiens KIF15 protein protein. 61 2e-08
BC008425-1|AAH08425.1| 285|Homo sapiens tropomyosin 3 protein. 61 2e-08
BC008407-1|AAH08407.1| 285|Homo sapiens tropomyosin 3 protein. 61 2e-08
AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit S... 61 2e-08
AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein. 61 2e-08
AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 1... 61 2e-08
AY165122-1|AAO39147.1| 1995|Homo sapiens myosin heavy chain prot... 61 2e-08
AL590431-11|CAH71269.1| 284|Homo sapiens tropomyosin 3 protein. 61 2e-08
AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein p... 61 2e-08
AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant... 61 2e-08
AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant... 61 2e-08
BC056146-1|AAH56146.1| 718|Homo sapiens hook homolog 3 (Drosoph... 60 3e-08
AL832009-1|CAD89912.1| 1177|Homo sapiens hypothetical protein pr... 60 3e-08
AF241830-1|AAK29204.1| 718|Homo sapiens golgi-associated microt... 60 3e-08
U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein. 60 4e-08
BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-... 60 4e-08
BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-... 60 4e-08
BC126912-1|AAI26913.1| 1132|Homo sapiens CROCC protein protein. 60 4e-08
BC126911-1|AAI26912.1| 1132|Homo sapiens CROCC protein protein. 60 4e-08
AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-... 60 4e-08
AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-... 60 4e-08
AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein... 60 4e-08
AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein. 60 4e-08
AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein. 60 4e-08
X63105-1|CAA44819.1| 726|Homo sapiens Tpr protein. 60 6e-08
D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein. 60 6e-08
BC094764-1|AAH94764.1| 692|Homo sapiens TPR protein protein. 60 6e-08
BC071583-1|AAH71583.1| 1139|Homo sapiens DCTN1 protein protein. 60 6e-08
BC016514-1|AAH16514.1| 687|Homo sapiens TPR protein protein. 60 6e-08
AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens ... 60 6e-08
AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein. 60 6e-08
AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein. 60 6e-08
X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (... 59 8e-08
M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac m... 59 8e-08
X03541-1|CAA27243.1| 641|Homo sapiens protein ( Human mRNA of t... 59 1e-07
L12579-1|AAA35654.1| 678|Homo sapiens protein ( Human alternati... 59 1e-07
BC066592-1|AAH66592.1| 1516|Homo sapiens CUTL1 protein protein. 59 1e-07
BC050058-1|AAH50058.1| 703|Homo sapiens Unknown (protein for MG... 59 1e-07
BC043398-1|AAH43398.1| 805|Homo sapiens CEP290 protein protein. 59 1e-07
AK222832-1|BAD96552.1| 678|Homo sapiens CCAAT displacement prot... 59 1e-07
AC005086-1|AAP22331.1| 317|Homo sapiens unknown protein. 59 1e-07
AB059622-1|BAB69690.1| 1594|Homo sapiens Rb1-inducible coiled co... 59 1e-07
AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A p... 58 1e-07
AL590431-10|CAH71268.1| 247|Homo sapiens tropomyosin 3 protein. 58 1e-07
AL589649-3|CAH71820.1| 1213|Homo sapiens filamin A interacting p... 58 1e-07
AL589649-1|CAH71818.1| 1114|Homo sapiens filamin A interacting p... 58 1e-07
AL445465-2|CAH73615.1| 1213|Homo sapiens filamin A interacting p... 58 1e-07
AL445465-1|CAH73614.1| 1114|Homo sapiens filamin A interacting p... 58 1e-07
AL365436-2|CAI16590.1| 1203|Homo sapiens cingulin protein. 58 1e-07
AF263462-1|AAF74498.1| 1203|Homo sapiens cingulin protein. 58 1e-07
AB086011-1|BAC77067.1| 1213|Homo sapiens L-FILIP protein. 58 1e-07
AB037740-1|BAA92557.1| 1208|Homo sapiens KIAA1319 protein protein. 58 1e-07
AB033101-1|BAA86589.1| 1140|Homo sapiens KIAA1275 protein protein. 58 1e-07
X98801-1|CAA67333.1| 1263|Homo sapiens dynactin protein. 58 2e-07
M75165-1|AAB59509.1| 284|Homo sapiens tropomyosin protein. 58 2e-07
M74817-1|AAA61230.1| 284|Homo sapiens tropomyosin-1 protein. 58 2e-07
M12125-1|AAA36773.1| 284|Homo sapiens protein ( Human fibroblas... 58 2e-07
BC025422-1|AAH25422.1| 676|Homo sapiens cut-like 1, CCAAT displ... 58 2e-07
BC011776-1|AAH11776.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 58 2e-07
AL133410-2|CAI10974.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 58 2e-07
AK223258-1|BAD96978.1| 284|Homo sapiens tropomyosin 2 (beta) is... 58 2e-07
AK026958-1|BAB15602.1| 715|Homo sapiens protein ( Homo sapiens ... 58 2e-07
AF086947-1|AAD03694.1| 1261|Homo sapiens dynactin 1 protein. 58 2e-07
AF064205-2|AAD55812.1| 1144|Homo sapiens dynactin 1 p135 isoform... 58 2e-07
AF064205-1|AAD55811.1| 1278|Homo sapiens dynactin 1 p150 isoform... 58 2e-07
AB209625-1|BAD92862.1| 459|Homo sapiens dynactin 1 isoform 1 va... 58 2e-07
BX538286-1|CAD98081.1| 724|Homo sapiens hypothetical protein pr... 58 2e-07
AY640415-1|AAT68295.1| 284|Homo sapiens tropomyosin alpha stria... 58 2e-07
AL590431-12|CAH71270.1| 242|Homo sapiens tropomyosin 3 protein. 58 2e-07
AL139421-4|CAI22511.1| 720|Homo sapiens coiled-coil domain cont... 58 2e-07
AK092690-1|BAC03946.1| 243|Homo sapiens protein ( Homo sapiens ... 58 2e-07
AK027705-1|BAB55310.1| 965|Homo sapiens protein ( Homo sapiens ... 58 2e-07
D86958-1|BAA13194.2| 1593|Homo sapiens KIAA0203 protein. 57 3e-07
D63997-1|BAA23661.1| 1530|Homo sapiens GCP170 protein. 57 3e-07
BC111801-1|AAI11802.1| 703|Homo sapiens ROCK2 protein protein. 57 3e-07
BC086869-1|AAH86869.1| 954|Homo sapiens FLJ25770 protein protein. 57 3e-07
BC017556-1|AAH17556.1| 1594|Homo sapiens RB1-inducible coiled-co... 57 3e-07
AL590431-9|CAH71267.1| 248|Homo sapiens tropomyosin 3 protein. 57 3e-07
AK131384-1|BAD18535.1| 326|Homo sapiens protein ( Homo sapiens ... 57 3e-07
AK131080-1|BAC85130.1| 563|Homo sapiens FLJ00279 protein protein. 57 3e-07
AF250731-1|AAO27830.1| 713|Homo sapiens centrosomal colon cance... 57 3e-07
AF209746-1|AAF17621.1| 257|Homo sapiens beta tropomyosin protein. 57 3e-07
AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein. 57 3e-07
AB208965-1|BAD92202.1| 705|Homo sapiens Rho-associated, coiled-... 57 3e-07
AB027133-1|BAB71953.1| 1390|Homo sapiens male enhanced antigen-2... 57 3e-07
M19713-1|AAA61225.1| 284|Homo sapiens TPM1 protein. 57 4e-07
AL590543-3|CAI10943.1| 722|Homo sapiens chromosome 6 open readi... 57 4e-07
AL359494-1|CAH71980.1| 722|Homo sapiens chromosome 6 open readi... 57 4e-07
AL133410-1|CAI10975.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 57 4e-07
AF485338-1|AAL93149.1| 1498|Homo sapiens golgin-160 protein. 57 4e-07
AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-... 57 4e-07
AB053469-1|BAC54108.1| 720|Homo sapiens ELKS gamma protein. 57 4e-07
Z11584-1|CAA77670.1| 2101|Homo sapiens NuMA protein protein. 56 5e-07
AK023677-1|BAB14636.1| 574|Homo sapiens protein ( Homo sapiens ... 56 5e-07
X06825-1|CAA29971.1| 284|Homo sapiens protein ( Human mRNA for ... 56 7e-07
AL133410-4|CAI10977.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 56 7e-07
AL133410-3|CAI10976.1| 322|Homo sapiens tropomyosin 2 (beta) pr... 56 7e-07
AK092490-1|BAC03904.1| 280|Homo sapiens protein ( Homo sapiens ... 56 7e-07
AF461266-1|AAL67520.1| 606|Homo sapiens RUFY2 protein. 56 7e-07
AF411980-1|AAL04164.1| 590|Homo sapiens Run- and FYVE-domain co... 56 7e-07
AB046785-1|BAB13391.2| 1313|Homo sapiens KIAA1565 protein protein. 56 7e-07
AB041533-1|BAB16440.1| 759|Homo sapiens sperm antigen protein. 56 7e-07
AB040970-1|BAA96061.1| 619|Homo sapiens KIAA1537 protein protein. 56 7e-07
BC114627-1|AAI14628.1| 790|Homo sapiens SLMAP protein protein. 56 9e-07
BC060803-1|AAH60803.1| 715|Homo sapiens chromosome 6 open readi... 56 9e-07
BC057235-1|AAH57235.1| 613|Homo sapiens HMMR protein protein. 56 9e-07
AL590431-5|CAH71266.1| 248|Homo sapiens tropomyosin 3 protein. 56 9e-07
AJ271784-1|CAB75427.1| 1232|Homo sapiens chromokinesin protein. 56 9e-07
AF474157-1|AAL84570.1| 247|Homo sapiens TPMsk3 protein. 56 9e-07
M21665-1|AAA36345.1| 524|Homo sapiens protein ( Human beta-myos... 55 1e-06
M19714-1|AAA61226.1| 264|Homo sapiens TPM1 protein. 55 1e-06
D67035-1|BAA22586.1| 973|Homo sapiens SCP-1 protein. 55 1e-06
BX538186-1|CAD98058.1| 971|Homo sapiens hypothetical protein pr... 55 1e-06
BC048304-1|AAH48304.1| 597|Homo sapiens HOOK3 protein protein. 55 1e-06
AK097517-1|BAC05084.1| 621|Homo sapiens protein ( Homo sapiens ... 55 1e-06
AK027881-1|BAB55428.1| 690|Homo sapiens protein ( Homo sapiens ... 55 1e-06
AF317887-1|AAK01919.1| 589|Homo sapiens monoclonal antibody 3H1... 55 1e-06
BC032762-1|AAH32762.1| 571|Homo sapiens OPTN protein protein. 55 2e-06
BC013876-1|AAH13876.1| 577|Homo sapiens optineurin protein. 55 2e-06
AF420373-1|AAL76329.1| 577|Homo sapiens optineurin isoform 3 pr... 55 2e-06
AF420372-1|AAL76328.1| 577|Homo sapiens optineurin isoform 2 pr... 55 2e-06
AF420371-1|AAL76327.1| 577|Homo sapiens optineurin isoform 1 pr... 55 2e-06
AF041004-1|AAD17459.1| 1756|Homo sapiens periplakin protein. 55 2e-06
AF013717-1|AAC39668.1| 1756|Homo sapiens periplakin protein. 55 2e-06
AF001691-1|AAC17738.1| 1756|Homo sapiens 195 kDa cornified envel... 55 2e-06
Z97054-3|CAI42646.1| 1233|Homo sapiens structural maintenance of... 54 2e-06
S78271-1|AAB34405.1| 1233|Homo sapiens SB1.8/DXS423E protein. 54 2e-06
D80000-1|BAA11495.2| 1233|Homo sapiens KIAA0178 protein. 54 2e-06
BC112127-1|AAI12128.1| 1233|Homo sapiens SMC1 structural mainten... 54 2e-06
BC108904-1|AAI08905.1| 725|Homo sapiens hyaluronan-mediated mot... 54 2e-06
BC033618-1|AAH33618.1| 481|Homo sapiens SPECC1 protein protein. 54 2e-06
BC029425-1|AAH29425.1| 272|Homo sapiens Unknown (protein for IM... 54 2e-06
BC021123-1|AAH21123.2| 987|Homo sapiens sperm antigen with calp... 54 2e-06
AY816329-1|AAW30002.1| 1068|Homo sapiens structure protein NSP5b... 54 2e-06
AY816328-1|AAW30001.1| 790|Homo sapiens structure protein NSP5b... 54 2e-06
AY816327-1|AAW30000.1| 987|Homo sapiens structure protein NSP5a... 54 2e-06
AY816326-1|AAW29999.1| 709|Homo sapiens structure protein NSP5a... 54 2e-06
AL589986-1|CAH70024.1| 1943|Homo sapiens trichohyalin protein. 54 2e-06
AL161779-1|CAI42089.1| 1233|Homo sapiens structural maintenance ... 54 2e-06
AF273044-1|AAG34904.1| 761|Homo sapiens CTCL tumor antigen se2-... 54 2e-06
M63618-1|AAA35606.1| 2095|Homo sapiens bullous pemphigoid antige... 54 3e-06
L11690-1|AAA52288.1| 2649|Homo sapiens bullous pemphigoid antige... 54 3e-06
CR533567-1|CAG38598.1| 691|Homo sapiens KIAA1536 protein. 54 3e-06
BX537985-1|CAD97945.1| 1202|Homo sapiens hypothetical protein pr... 54 3e-06
BC032639-1|AAH32639.1| 1220|Homo sapiens eukaryotic translation ... 54 3e-06
BC003177-1|AAH03177.1| 691|Homo sapiens calcium binding and coi... 54 3e-06
AY563137-1|AAT68474.1| 691|Homo sapiens calphoglin protein. 54 3e-06
AY358397-1|AAQ88763.1| 691|Homo sapiens EESP2436 protein. 54 3e-06
AY004867-1|AAF87083.1| 247|Homo sapiens tropomyosin isoform pro... 54 3e-06
AL133563-1|CAB63717.1| 1132|Homo sapiens hypothetical protein pr... 54 3e-06
AL096710-6|CAI22047.1| 2649|Homo sapiens dystonin protein. 54 3e-06
AJ006776-1|CAB44357.1| 1220|Homo sapiens IF2 protein protein. 54 3e-06
AC079447-4|AAX93258.1| 492|Homo sapiens unknown protein. 54 3e-06
AB040969-1|BAA96060.1| 645|Homo sapiens KIAA1536 protein protein. 54 3e-06
AB018284-1|BAA34461.2| 1222|Homo sapiens KIAA0741 protein protein. 54 3e-06
M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myo... 54 4e-06
BC130385-1|AAI30386.1| 1197|Homo sapiens structural maintenance ... 54 4e-06
BC114620-1|AAI14621.1| 1756|Homo sapiens periplakin protein. 54 4e-06
BC023021-1|AAH23021.1| 731|Homo sapiens golgi autoantigen, golg... 54 4e-06
AY644768-1|AAV85456.1| 731|Homo sapiens cell proliferation-indu... 54 4e-06
AL590431-8|CAH71265.1| 232|Homo sapiens tropomyosin 3 protein. 54 4e-06
AL354938-1|CAI16923.1| 1197|Homo sapiens structural maintenance ... 54 4e-06
AL161791-1|CAI16866.1| 1197|Homo sapiens structural maintenance ... 54 4e-06
AL031283-6|CAI21428.1| 692|Homo sapiens forkhead-associated (FH... 54 4e-06
AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20... 54 4e-06
AF085199-1|AAD09753.1| 731|Homo sapiens golgin-84 protein. 54 4e-06
AB011140-1|BAA25494.1| 1426|Homo sapiens KIAA0568 protein protein. 54 4e-06
BC016162-1|AAH16162.1| 314|Homo sapiens PPP1R9B protein protein. 53 5e-06
AY422473-1|AAR13704.1| 1326|Homo sapiens myosin tail domain-cont... 53 5e-06
AL662788-1|CAI95333.1| 1326|Homo sapiens chromosome 9 open readi... 53 5e-06
AL592153-1|CAI95316.1| 1326|Homo sapiens chromosome 9 open readi... 53 5e-06
AL359877-3|CAI94977.1| 1326|Homo sapiens chromosome 9 open readi... 53 5e-06
AL355355-6|CAI16549.1| 577|Homo sapiens optineurin protein. 53 5e-06
AL355355-5|CAI16550.1| 571|Homo sapiens optineurin protein. 53 5e-06
AK090540-1|BAC03473.1| 373|Homo sapiens protein ( Homo sapiens ... 53 5e-06
AJ401189-1|CAC37685.1| 817|Homo sapiens neurabin II protein pro... 53 5e-06
AF293357-1|AAL37035.1| 436|Homo sapiens AT2 receptor-interactin... 53 5e-06
AF121259-1|AAG33674.1| 436|Homo sapiens transcription factor MT... 53 5e-06
AF092563-1|AAC72360.1| 1197|Homo sapiens chromosome-associated p... 53 5e-06
AF032862-1|AAC32548.1| 724|Homo sapiens intracellular hyaluroni... 53 5e-06
AB033114-1|BAA86602.1| 1245|Homo sapiens KIAA1288 protein protein. 53 5e-06
Z98949-1|CAI17892.1| 2566|Homo sapiens protein ( Human DNA seque... 53 7e-06
X04588-1|CAB37185.1| 248|Homo sapiens protein ( Human 2.5 kb mR... 53 7e-06
BC090932-1|AAH90932.1| 1377|Homo sapiens NIN protein protein. 53 7e-06
BC072428-1|AAH72428.1| 248|Homo sapiens tropomyosin 3 protein. 53 7e-06
BC057227-1|AAH57227.1| 318|Homo sapiens Unknown (protein for IM... 53 7e-06
BC015403-1|AAH15403.1| 248|Homo sapiens tropomyosin 3 protein. 53 7e-06
BC004524-1|AAH04524.1| 395|Homo sapiens EF-hand calcium binding... 53 7e-06
BC000771-1|AAH00771.1| 248|Homo sapiens tropomyosin 3 protein. 53 7e-06
AY359522-1|AAQ57128.1| 657|Homo sapiens hypothetical protein DK... 53 7e-06
AL834265-1|CAD38940.1| 505|Homo sapiens hypothetical protein pr... 53 7e-06
AL590431-7|CAH71264.1| 248|Homo sapiens tropomyosin 3 protein. 53 7e-06
AL445928-1|CAH72248.1| 657|Homo sapiens novel protein protein. 53 7e-06
AL080245-1|CAI16965.1| 2566|Homo sapiens protein ( Human DNA seq... 53 7e-06
AL079300-1|CAI17881.1| 2566|Homo sapiens protein ( Human DNA seq... 53 7e-06
AL022329-3|CAI17968.1| 2566|Homo sapiens protein ( Human DNA seq... 53 7e-06
AK097021-1|BAC04928.1| 512|Homo sapiens protein ( Homo sapiens ... 53 7e-06
AF091711-1|AAD39719.1| 1773|Homo sapiens splice variant AKAP350 ... 53 7e-06
AF078035-1|AAD16006.1| 1220|Homo sapiens translation initiation ... 53 7e-06
U22816-1|AAC50173.1| 1202|Homo sapiens LAR-interacting protein 1... 52 9e-06
U22815-1|AAC50172.1| 1185|Homo sapiens LAR-interacting protein 1... 52 9e-06
L06148-1|AAA35921.1| 579|Homo sapiens golgin-165 protein. 52 9e-06
BC101520-1|AAI01521.1| 1194|Homo sapiens protein tyrosine phosph... 52 9e-06
BC101518-1|AAI01519.1| 1194|Homo sapiens protein tyrosine phosph... 52 9e-06
BC101026-1|AAI01027.1| 490|Homo sapiens SASS6 protein protein. 52 9e-06
BC048203-1|AAH48203.1| 663|Homo sapiens Unknown (protein for IM... 52 9e-06
BC034046-1|AAH34046.1| 1202|Homo sapiens protein tyrosine phosph... 52 9e-06
AY166853-1|AAO17292.1| 1317|Homo sapiens kinesin motor protein p... 52 9e-06
AL118509-3|CAI43063.2| 1392|Homo sapiens chromosome 20 open read... 52 9e-06
AL118509-2|CAM28305.1| 1317|Homo sapiens chromosome 20 open read... 52 9e-06
AL117376-3|CAI43180.2| 1392|Homo sapiens chromosome 20 open read... 52 9e-06
AL117376-2|CAI43181.2| 1317|Homo sapiens chromosome 20 open read... 52 9e-06
AL049794-2|CAI22745.2| 1392|Homo sapiens chromosome 20 open read... 52 9e-06
AL049794-1|CAM28307.1| 1317|Homo sapiens chromosome 20 open read... 52 9e-06
AK097432-1|BAC05050.1| 466|Homo sapiens protein ( Homo sapiens ... 52 9e-06
AF332010-1|AAO32947.1| 676|Homo sapiens CDV-1R variant b protein. 52 9e-06
AF283527-1|AAG00497.1| 577|Homo sapiens FIP2 protein. 52 9e-06
AF250326-1|AAL50343.1| 676|Homo sapiens CDV-1R protein. 52 9e-06
AF139540-1|AAP97269.1| 676|Homo sapiens CDV protein protein. 52 9e-06
AF061034-2|AAC16047.1| 520|Homo sapiens FIP2 protein. 52 9e-06
AF061034-1|AAC16046.1| 577|Homo sapiens FIP2 protein. 52 9e-06
AB067524-1|BAB67830.1| 704|Homo sapiens KIAA1937 protein protein. 52 9e-06
AB046810-1|BAB13416.2| 1393|Homo sapiens KIAA1590 protein protein. 52 9e-06
AB014554-1|BAA31629.2| 1267|Homo sapiens KIAA0654 protein protein. 52 9e-06
BC033545-1|AAH33545.1| 700|Homo sapiens cancer antigen 1 protein. 52 1e-05
BC026194-1|AAH26194.1| 700|Homo sapiens cancer antigen 1 protein. 52 1e-05
BC022260-1|AAH22260.1| 400|Homo sapiens Unknown (protein for IM... 52 1e-05
AL139095-7|CAI16451.1| 847|Homo sapiens cancer antigen 1 protein. 52 1e-05
AL139095-5|CAI16449.1| 545|Homo sapiens cancer antigen 1 protein. 52 1e-05
AK097760-1|BAC05162.1| 824|Homo sapiens protein ( Homo sapiens ... 52 1e-05
AF414185-1|AAO47239.1| 641|Homo sapiens CAGE-1 protein. 52 1e-05
AB046861-1|BAB13467.1| 718|Homo sapiens KIAA1641 protein protein. 52 1e-05
BC115701-1|AAI15702.1| 828|Homo sapiens SLMAP protein protein. 52 2e-05
BC092419-1|AAH92419.1| 701|Homo sapiens hypothetical LOC550631 ... 52 2e-05
BC077732-1|AAH77732.1| 662|Homo sapiens FKBP15 protein protein. 52 2e-05
BC053545-1|AAH53545.1| 245|Homo sapiens tropomyosin 1 (alpha) p... 52 2e-05
BC045832-1|AAH45832.1| 249|Homo sapiens SDCCAG8 protein protein. 52 2e-05
BC006984-1|AAH06984.1| 512|Homo sapiens Unknown (protein for IM... 52 2e-05
AK091549-1|BAC03690.1| 623|Homo sapiens protein ( Homo sapiens ... 52 2e-05
AK023385-1|BAB14554.1| 284|Homo sapiens protein ( Homo sapiens ... 52 2e-05
AF092564-1|AAC72361.1| 1202|Homo sapiens chromosome-associated p... 52 2e-05
AB019987-1|BAA73535.1| 1288|Homo sapiens chromosome-associated p... 52 2e-05
AB018346-1|BAA34523.1| 1708|Homo sapiens KIAA0803 protein protein. 52 2e-05
DQ424903-1|ABD83668.1| 245|Homo sapiens tropomyosin 1 alpha var... 51 2e-05
BC013023-1|AAH13023.1| 1193|Homo sapiens NUMA1 protein protein. 51 2e-05
AL449305-3|CAI10964.1| 1244|Homo sapiens FK506 binding protein 1... 51 2e-05
AL449105-1|CAI95402.1| 1244|Homo sapiens FK506 binding protein 1... 51 2e-05
AF115510-1|AAD41258.1| 603|Homo sapiens LRR FLI-I interacting p... 51 2e-05
AB014574-1|BAA31649.1| 1234|Homo sapiens KIAA0674 protein protein. 51 2e-05
U29343-1|AAC52049.1| 725|Homo sapiens hyaluronan receptor protein. 51 3e-05
DQ139275-1|ABA43896.1| 1313|Homo sapiens Tax1-binding protein 2 ... 51 3e-05
BT019621-1|AAV38427.1| 419|Homo sapiens inhibitor of kappa ligh... 51 3e-05
BC070281-1|AAH70281.1| 552|Homo sapiens HMMR protein protein. 51 3e-05
BC050612-1|AAH50612.1| 419|Homo sapiens IKBKG protein protein. 51 3e-05
BC047324-1|AAH47324.1| 1217|Homo sapiens structural maintenance ... 51 3e-05
BC046922-1|AAH46922.1| 419|Homo sapiens IKBKG protein protein. 51 3e-05
BC012114-1|AAH12114.1| 419|Homo sapiens IKBKG protein protein. 51 3e-05
BC000299-1|AAH00299.1| 419|Homo sapiens IKBKG protein protein. 51 3e-05
AY533564-1|AAS45545.2| 2039|Homo sapiens ankyrin repeat-containi... 51 3e-05
AY373757-1|AAR25662.1| 2062|Homo sapiens ankyrin repeat-containi... 51 3e-05
AY114157-1|AAM44073.1| 487|Homo sapiens inhibitor of kappaB kin... 51 3e-05
AY077700-1|AAL75811.1| 2568|Homo sapiens myosin-like protein pro... 51 3e-05
AL451125-2|CAI14346.1| 767|Homo sapiens golgi autoantigen, golg... 51 3e-05
AL450306-3|CAI17324.2| 1919|Homo sapiens discs, large homolog 5 ... 51 3e-05
AL391421-2|CAI12104.2| 1919|Homo sapiens discs, large homolog 5 ... 51 3e-05
AL359260-2|CAI16576.1| 1217|Homo sapiens structural maintenance ... 51 3e-05
AL354928-1|CAI39632.1| 767|Homo sapiens golgi autoantigen, golg... 51 3e-05
AJ310932-1|CAC70714.3| 2567|Homo sapiens myosin heavy chain prot... 51 3e-05
AJ310931-1|CAC70712.2| 2567|Homo sapiens myosin heavy chain prot... 51 3e-05
AJ271718-1|CAB93146.1| 419|Homo sapiens NF-KB Essential Modulat... 51 3e-05
AF352034-1|AAL83938.1| 1809|Homo sapiens DLG5 protein. 51 3e-05
AF317425-1|AAG38609.1| 2062|Homo sapiens GAC-1 protein. 51 3e-05
AF277315-2|AAL27012.1| 419|Homo sapiens NFkappaB essential modu... 51 3e-05
AF261086-1|AAF99679.1| 419|Homo sapiens NF-kB essential modulat... 51 3e-05
AF091453-1|AAD38081.1| 419|Homo sapiens NEMO protein protein. 51 3e-05
AF074382-1|AAC36330.1| 419|Homo sapiens IkB kinase gamma subuni... 51 3e-05
AF020043-1|AAC14893.1| 1217|Homo sapiens chromosome-associated p... 51 3e-05
AB208841-1|BAD92078.1| 1585|Homo sapiens Nuclear mitotic apparat... 51 3e-05
AB075376-1|BAC16363.1| 2567|Homo sapiens bk125H2.1 protein. 51 3e-05
AB042648-1|BAB55550.2| 2080|Homo sapiens bk125H2.1 protein. 51 3e-05
AB020671-1|BAA74887.2| 1402|Homo sapiens KIAA0864 protein protein. 51 3e-05
AB011155-1|BAA25509.2| 1952|Homo sapiens KIAA0583 protein protein. 51 3e-05
M25142-1|AAA60387.1| 389|Homo sapiens myosin heavy chain alpha-... 50 3e-05
L16782-1|AAC37542.1| 566|Homo sapiens putative M phase phosphop... 50 3e-05
BX537396-1|CAD97638.1| 442|Homo sapiens hypothetical protein pr... 50 3e-05
BC036523-1|AAH36523.1| 411|Homo sapiens MIPOL1 protein protein. 50 3e-05
BC035870-1|AAH35870.1| 261|Homo sapiens MIPOL1 protein protein. 50 3e-05
BC008345-1|AAH08345.1| 963|Homo sapiens Unknown (protein for IM... 50 3e-05
AY640414-1|AAT68294.1| 284|Homo sapiens sarcomeric tropomyosin ... 50 3e-05
AY059470-1|AAL27798.1| 442|Homo sapiens mirror-image polydactyl... 50 3e-05
AF352033-1|AAL83937.1| 1809|Homo sapiens DLG5 protein. 50 3e-05
AF062089-1|AAD12183.1| 419|Homo sapiens leucine zipper protein ... 50 3e-05
AB209992-1|BAE06074.1| 2319|Homo sapiens DSP variant protein pro... 50 3e-05
BC111719-1|AAI11720.2| 1147|Homo sapiens caspase recruitment dom... 50 5e-05
AK074049-1|BAB84875.1| 1171|Homo sapiens FLJ00120 protein protein. 50 5e-05
AF495910-1|AAN60442.1| 8797|Homo sapiens nesprin-1 protein. 50 5e-05
U51587-1|AAB81549.1| 767|Homo sapiens Golgi complex autoantigen... 50 6e-05
M19267-1|AAA36771.1| 284|Homo sapiens protein ( Human tropomyos... 50 6e-05
D11393-1|BAA01989.1| 208|Homo sapiens human non-muscle myosin h... 50 6e-05
BC089426-1|AAH89426.1| 840|Homo sapiens establishment of cohesi... 50 6e-05
>X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein.
Length = 1411
Score = 113 bits (271), Expect = 4e-24
Identities = 229/1050 (21%), Positives = 436/1050 (41%), Gaps = 97/1050 (9%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM--E 118
Q LKE +E+ K + L E +++Q+ E + L L+++ L +++ E
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQRE--EKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 119 NLTKDKEIKNLT-DSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
+ KE + L+ + L K +++ +LQ + L + E VT S L ++D K+ ++
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ- 491
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
Q+ + E + + + Q K+ IQ+L SK N S+ +
Sbjct: 492 -EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK--SKENISLLEKERED 548
Query: 238 RYNKICTLQSE---LDAGREDCKELCEDFTSI----KNHLELHEPNMTMDLDEKLGENNE 290
Y KI + E L+ +E L E T + KN E H+ +L +++ E
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE-NLHDQVQEQKA 607
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID-RYKDSLLAVLDAEFGTTSLDVFE 349
A + ++ ++N L+ QL NESK+ +D + K +L AE T+
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQL--NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD- 664
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE-KENACNIL 408
+ N ++ Q L + ++ K+ L++ T++L+ E + L S L E KE ++
Sbjct: 665 --LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL- 721
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++ E+ I K E + E+ + L L+ R L+ DL + T L
Sbjct: 722 ---EQKTEELEG----QIKKLEADSLEVKASKEQALQDLQQQ--RQLNTDLEL--RATEL 770
Query: 469 FDALITQYEL-SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L + E+ S T +++K+ LE+ K F+TL + E K
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALES--IKQKLTKQEEEKQILKQDFETLSQ---ETKI 825
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS---EKDNKLTE- 583
HEEL ++ V E + L E+ +K ++K + + + EK+N+ +
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
Query: 584 -LVSTINGLKEENNSLK-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
++ KE + L+ + + + +KE + S LE+ + Q EL+ M+ ++
Sbjct: 886 AILDLEKTCKELKHQLQVQMENTLKEQKELKKS-LEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCSRL--EINIKTHEKTAEIQNR 698
++ + L+ N+ LK+ E+K + L E+ I +KT E++N+
Sbjct: 945 NTLKQN--------EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT-ELENK 995
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ +L + QE L EKE K++ L N YE + + D RE+ L T++DL
Sbjct: 996 LQQQLTQAAQE---LAAEKE-KISVLQNNYEKSQETFKQLQSDFYG-RES-ELLATRQDL 1049
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
+E + Q + T ++ K +
Sbjct: 1050 -----KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA------KKEQQL 1098
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETCAEYLQERDEQCARLKK 877
+ + D + KE+ L ++EL + K + E+++ +C E + +E LK
Sbjct: 1099 QERCKALQDIQ----KEKSLK-EKELVNEKSKLAEIEEIKCRQEKEITKLNEE----LKS 1149
Query: 878 EKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
KL ++++NLK+ Q+ QQ +E Q K + +++ N ++ D++ + E E
Sbjct: 1150 HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN-QQILKDQVKKEEE-EL 1207
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
K ++ +L ++K M+K E K + A + L K E + ++R
Sbjct: 1208 KKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
Query: 996 KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALEKQIESLSNTPVSNS 1054
EL+++ + + E + + E + LE K + L+ ++ L + N+
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQR-KLDNT 1323
Query: 1055 TMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
T V Q+ QI N+K + N
Sbjct: 1324 TAAVQELGRENQSLQIKHTQALNRKWAEDN 1353
Score = 108 bits (259), Expect = 1e-22
Identities = 226/1043 (21%), Positives = 439/1043 (42%), Gaps = 116/1043 (11%)
Query: 55 ISCKMCQSLKESS----NEINLKLEKLSGELFDIKEQKSALEGKYQNLILE----TQTRD 106
+ C+ QS +S + I+++L + +KE+ S +E KYQ+L E Q R+
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 107 -------LLMSQIKSLEMENLTKD----------KEIKNL-TDSLKTKSKKINELQEEND 148
L S+I L + L + KE + L ++ L K +++ +LQ +
Sbjct: 404 EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463
Query: 149 TLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLK 208
L + E VT S L ++D K+ ++ Q+ + E + + + Q K
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQ--EQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 209 ENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSE---LDAGREDCKELCEDFT- 264
+ IQ+L SK N S+ + Y KI + E L+ +E L E T
Sbjct: 522 DQKIQNLEALLQK--SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQ 579
Query: 265 ---SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
+KN E H+ +L +++ E A + ++ ++N L+ QL NESK+
Sbjct: 580 LTEKLKNQSESHK-QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL--NESKEK 636
Query: 322 KDHID-RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+D + K +L AE T+ + N ++ Q L + ++ K+ L++
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQ---RADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
Query: 381 TSELKSVNEKLASLNSQLIE-KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
T++L+ E + L S L E KE ++ +++ E+ I K E + E+
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSL----EQKTEELEG----QIKKLEADSLEVKAS 745
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL-SRTDYEIEKEKLRLETGTAK 498
+ L L+ R L+ DL + T L L + E+ S T +++K+ LE + K
Sbjct: 746 KEQALQDLQQQ--RQLNTDL--ELRATELSKQLEMEKEIVSSTRLDLQKKSEALE--SIK 799
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
F+TL + E K HEEL ++ V E + L E+
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 559 ALKIAIAKNEEKM---LSLSEKDNK--LTELVSTINGLKEENNSLK-SLNDVITREKETQ 612
+K ++K + + S EK+N+ ++ KE + L+ + + + +KE +
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQ 671
S LE+ + Q EL+ M+ ++ ++ + L+ N+ LK+
Sbjct: 917 KS-LEKEKEASHQLKLELNSMQEQLIQ--------AQNTLKQNEKEEQQLQGNINELKQS 967
Query: 672 CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
E+K + L E+ I +KT E++N++ +L + QE L EKE K++ L N YE
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKT-ELENKLQQQLTQAAQE---LAAEKE-KISVLQNNYE 1022
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
+ + D RE+ L T++DL +E + Q +
Sbjct: 1023 KSQETFKQLQSDF-YGRES-ELLATRQDL-----KSVEEKLSLAQEDLISNRNQIGNQNK 1075
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
T ++ K + + + D + KE+ L ++EL + K
Sbjct: 1076 LIQELKTAKATLEQ------DSAKKEQQLQERCKALQDIQ----KEKSLK-EKELVNEKS 1124
Query: 850 RYKELDD-ECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFA 906
+ E+++ +C E + +E LK KL ++++NLK+ Q+ QQ +E Q K
Sbjct: 1125 KLAEIEEIKCRQEKEITKLNEE----LKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE---ELRYKKQDLKNTVTKMQKA 963
+ +++ N ++ D++ + E K + + K + E++ K+ +K K
Sbjct: 1181 SLKAAVEQEKRN-QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
Query: 964 MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAK 1023
+ T ++ +KE + + + EL+++ +L E ++ +++ + L E
Sbjct: 1240 TMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERC 1299
Query: 1024 IALE-IVDKLSNQKVALEKQIES 1045
+ E ++KL + + L++++++
Sbjct: 1300 LKGEGEIEKLQTKVLELQRKLDN 1322
Score = 89.8 bits (213), Expect = 5e-17
Identities = 209/1071 (19%), Positives = 439/1071 (40%), Gaps = 93/1071 (8%)
Query: 61 QSLKESSNEINLKL-EKLSGELFDIKEQKSAL---EGKYQNLILE---TQTRDLLMSQIK 113
+SL+E++ + +L E+L+ E I++ K+ L G +L+ Q + L+ +
Sbjct: 183 RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTL 242
Query: 114 SLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK 173
E E+ E K L + I++L+ E + V E L V++L +
Sbjct: 243 ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
Query: 174 NNECLTQKCI----DLEKLVNE-SENKIGPKNICAQCKLKE---NLIQSLHIGYDNTLSK 225
N+ LT+ + D KL + +E + KNI A K+ +QS + +L +
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 226 LNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKL 285
++ +S+ +T+ K+ SE++ + K + + E H + ++++
Sbjct: 363 IHVELSEKGEATQ--KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 286 GENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL 345
+ E E + + +K SE+L++ E + + + K S L E T S
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL---KLSRLEEQLKEKVTNST 477
Query: 346 DVFEILMDNIINKYQIDL---DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
++ + +D ++Q K + Q DL + ++ ++K+ +L + L + +
Sbjct: 478 EL-QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
Query: 403 NACNILRIQKERIH------EISSAVTIDIVKKENELKEILTKECLKLS------KLKID 450
++L ++E ++ E +AV + +K + L+E +T+ KL K +
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 451 IPRDLDQDLPAHKKIT----ILFDALITQY--ELSRTDYEIEKEKLRLETGTAKAVXXXX 504
D Q+ AH + + + + + +L+ + ++ + ++++ T + +
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT-ELLLSAE 655
Query: 505 XXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAI 564
+ L+ A N ++ +EL K+ +++D+ A L + E L+ +
Sbjct: 656 AAKTAQRADLQNHLDTAQNALQDKQQELNKI-TTQLDQVTAKL---QDKQEHCSQLESHL 711
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
+ +EK LSL +K +L + K E +SL+ + KE +L++ Q+
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIK-----KLEADSLE-----VKASKEQALQDLQQQRQLNT 761
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
++ + M + +S+ ++ +E+ + +D L
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 685 NIKTHEKTAEIQNRM---IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
K + E+ NR+ + LQK E + L E T ++L+ ++LK K+
Sbjct: 822 ETKIQHE--ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Query: 742 LESSREAVNQLT-TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT 800
+ + A+ L T K+L ++E+ ++ ++
Sbjct: 880 NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 801 FGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
L +N K + + +I+ + S Q K+++ + Q EL + EL+++ +
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSS-EQKKKQIEALQGELKIAVLQKTELENKLQQ 998
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ Q E A +KEK+S+ Q ++ Q + + +++ T +D ++
Sbjct: 999 --QLTQAAQELAA--EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA-TRQDLKSVE 1053
Query: 921 SVVVDRMSYDAEVEKNK--RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKK----DKEF 974
+ D +N+ K I+EL+ K L+ K ++ +++ K KE
Sbjct: 1054 EKL-SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE-EQCKRLKEAKIALEIVDKLS 1033
K KEL + K++L E+++ ++E E LK + E K + K A ++ L
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL---LI 1169
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI--TDVMKENQKLKK 1082
QK+ L+ + +SL A +NQQI V KE ++LKK
Sbjct: 1170 QQKLELQGKADSLK-----------AAVEQEKRNQQILKDQVKKEEEELKK 1209
Score = 77.0 bits (181), Expect = 4e-13
Identities = 203/1092 (18%), Positives = 453/1092 (41%), Gaps = 108/1092 (9%)
Query: 62 SLKES---SNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
SLKE S E+ +LEK G +++Q++ +G + E Q+ L Q++ + E
Sbjct: 98 SLKEEKWYSEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQS---LEQQLEEAQTE 150
Query: 119 NLTKDKEIKNLTDS----LKTKSKKINELQEENDTLSNLIMENVTE-SDNLNKE---VDD 170
N K++K+L + L T+ I +E +L + VT ++ LNKE + D
Sbjct: 151 NFNI-KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
Query: 171 LK---------KNNECLTQKCIDLEKLVNES--ENKIGPKNICAQCKLKENLIQSLHIGY 219
LK ++ L ++ + ++ L++ E + + + +CK +QS +
Sbjct: 210 LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK----LQSQYASS 265
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTM 279
+ T+S+L ++ ++ EL + EL + ++ +L E + T
Sbjct: 266 EATISQLRSELAKGP-----QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 280 DLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID---------RYKD 330
L+EK E + + + + + L +L +E+ + H++ + K+
Sbjct: 321 -LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 379
Query: 331 SLLAV------LDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSEL 384
L V L AEF E + + Q +++++ K + + L E L
Sbjct: 380 ELSEVETKYQHLKAEFKQLQQQREEKEQHGL--QLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 385 KSVNEKLASLNSQLIEKENACNILRIQKERIHE-ISSAVT--------IDIVKKENELKE 435
K +L+S +L++KE L+++ R+ E + VT +D K++++ ++
Sbjct: 438 KE-QRQLSS--EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 436 ILTKECL-KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLET 494
L + KL + + D+ + L Q +KI L +AL+ + + + + E E+E L +
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL-EALLQKSKENISLLEKEREDLYAKI 553
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILS 554
+ + L+E ++ +L E++T+L + +++ ++ + L
Sbjct: 554 QAGEG-----------ETAVLNQLQEKNH---TLQEQVTQLTEKLKNQSESHKQAQENLH 599
Query: 555 EEIDALKIAIAKNEEKMLSLSEKDNKLT-------ELVSTIN-GLKEENNSLKSLNDVIT 606
+++ K + ++++LSL N+L E VS ++ +K + L S T
Sbjct: 600 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 607 REKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
++ + L+ + ++ EL+K+ + K E+ L
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 667 ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
+L+++ EE +LE + K ++ Q ++ Q+Q+ D +L + +K E+
Sbjct: 720 SLEQKTEELEGQIKKLEAD-SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 727 KYEALKR-DYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXX 785
+ + R D + LES ++ + + +K +++ L + + +
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTV 838
Query: 786 XXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELD 845
T +D + K+ DS K S S + E + K +L ++
Sbjct: 839 TELQKVKMEKEALMTELSTVKD--KLSKVSDSLKNSKSEF-EKENQKGKAAILDLEKTCK 895
Query: 846 DLKERYK-ELDD---ECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVER 901
+LK + + ++++ E + + L++ E +LK E S+++Q+ + ++ + E+
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
Q + + + + A ++K + K ++L Q+L K+
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKIS 1015
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL----KQREEQCK 1017
Y K + F+ + + ++EL +Q K ++E+ E L Q Q K
Sbjct: 1016 VLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK 1075
Query: 1018 RLKEAKIALEIVDKLSNQK-VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDV-MK 1075
++E K A +++ S +K L+++ ++L + S + + +I ++ +
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135
Query: 1076 ENQKLKKMNAKL 1087
+ +++ K+N +L
Sbjct: 1136 QEKEITKLNEEL 1147
Score = 60.9 bits (141), Expect = 2e-08
Identities = 161/838 (19%), Positives = 333/838 (39%), Gaps = 74/838 (8%)
Query: 246 QSELDAGREDCKELCEDFTSIKNHLE---LHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+S L R+D L ++ ++ L+ + + +L++ G + E K ++++
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ-EAKPDGLVTDS 133
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF-----EILMDNIIN 357
L SL +QL E++ +I + KD L A+ T D+ E +
Sbjct: 134 SAELQSLEQQL--EEAQTENFNIKQMKD-LFEQKAAQLATEIADIKSKYDEERSLREAAE 190
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
+ L E L K V DL + + E +A L +L++ + + + +++ER E
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGI-EDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIP---RDLDQDLPAHKKITILFDALIT 474
+ + + +++ +L+K ++ ++L + + ++T L
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
DY +EK E+ + K + L + + +H EL++
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369
Query: 535 LYKS--KVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTING 590
++ K+ E + + + L E L+ + E+ L L + N+L ++L+ T
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 591 LKEENNSLKSLNDVITR---EKETQASELERSCQVIKQ-------NGFELDKMKADILMX 640
L E + LK + + +KE Q ++L+ +++ N EL
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
EA++ LEQ L Q +K + LE ++ ++ + +
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVL---RQIGDKDQKIQNLEALLQKSKENISLLEKER 546
Query: 701 MRLQKQIQEDDKLFIEKETK-LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
L +IQ E ET LN+L K L+ + L++ E+ Q Q++L
Sbjct: 547 EDLYAKIQAG-----EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ--AQENLH 599
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPK 819
+ ++ E ++ +R Q + ++ L K
Sbjct: 600 D-QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK-------EKVSQLDIQIKAKTELL 651
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK--- 876
S ++ + L+ L + Q L D ++ ++ + + LQ++ E C++L+
Sbjct: 652 LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
Query: 877 ---KEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
KEK LSLEQ+ L+ QI+ + +A +V + ++ +L +++ D E
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIK-----KLEADSLEVKASKEQALQDLQQ--QRQLNTDLE 764
Query: 933 V---EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
+ E +K+L E + + DL+ ++ +K TK+++E + +++ E +
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS---Q 821
Query: 990 ELKQRYKELDEECETCAEYLK----QREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQ 1042
E K +++EL+ +T L+ ++E L K L ++ D L N K EK+
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Score = 41.1 bits (92), Expect = 0.021
Identities = 81/402 (20%), Positives = 161/402 (40%), Gaps = 40/402 (9%)
Query: 32 SKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSAL 91
S + +I+ Q N +K + + + LK+SS + ++E L GEL QK+ L
Sbjct: 935 SMQEQLIQAQ-NTLKQNEKEEQQLQGNI-NELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 92 EGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE-IKNL-------TDSLKTKSKKINEL 143
E K Q + + + S+ N K +E K L L + + +
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLK-----------KNNECLTQKCIDLEKLVNES 192
+E+ ++ N + N NK + +LK K + L ++C L+ + +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI--QK 1110
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
E + K + + K K I+ + + ++KLN + S+ +I L+
Sbjct: 1111 EKSLKEKELVNE-KSKLAEIEEIKCRQEKEITKLNEELK-SHKLESIKEITNLKDAKQLL 1168
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE----NNEFETKAVKVMSEIKRNLNS 308
+ EL S+K +E + N + D+ E EF K K+ SEIK
Sbjct: 1169 IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG 1228
Query: 309 LSEQLINNESKKS------KDHI----DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ + NE+K + +++ ++ S V + E T L +++ +
Sbjct: 1229 MKKH-EENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
Q + +LE+ K +G++ + +++ + KL + + + E
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329
>L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated protein
protein.
Length = 1410
Score = 113 bits (271), Expect = 4e-24
Identities = 212/968 (21%), Positives = 409/968 (42%), Gaps = 95/968 (9%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM--E 118
Q LKE +E+ K + L E +++Q+ E + L L+++ L +++ E
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQRE--EKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 119 NLTKDKEIKNLT-DSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
+ KE + L+ + L K +++ +LQ + L + E VT S L ++D K+ ++
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ- 491
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
Q+ + E + + + Q K+ IQ+L SK N S+ +
Sbjct: 492 -EQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQNLEALLQK--SKENISLLEKERED 548
Query: 238 RYNKICTLQSE---LDAGREDCKELCEDFT----SIKNHLELHEPNMTMDLDEKLGENNE 290
Y KI + E L+ +E L ++ T ++KN E H+ +L +++ E
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLTENVKNQSESHKQAQE-NLHDQVQEQKA 607
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID-RYKDSLLAVLDAEFGTTSLDVFE 349
A + ++ ++N L+ QL NESK+ +D + K +L AE T+
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQL--NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD- 664
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE-KENACNIL 408
+ N ++ Q L + ++ K+ L++ T++L+ E + L S L E KE ++
Sbjct: 665 --LQNHLDTAQNALQDKHQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL- 721
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++ E+ I K E + E+ + L L+ R L+ DL + T L
Sbjct: 722 ---EQKTEELEG----QIKKLEADSLEVKASKEQALQDLQQQ--RQLNTDLEL--RATEL 770
Query: 469 FDALITQYEL-SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L + E+ S T +++K+ LE+ K F+TL + E K
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALES--IKQKLTKQEEEKQILKQDFETLSQ---ETKI 825
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS---EKDNKLTE- 583
HEEL ++ V E + L E+ +K ++K + + + EK+N+ +
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
Query: 584 -LVSTINGLKEENNSLK-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
++ KE + L+ + + + +KE + S LE+ + Q EL+ M+ ++
Sbjct: 886 AILDLEKTCKELKHQLQVQMENTLKEQKELKKS-LEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCSRL--EINIKTHEKTAEIQNR 698
++ + L+ N+ LK+ E+K + L E+ I +KT E++N+
Sbjct: 945 NTLKQN--------EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT-ELENK 995
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ +L + QE L EKE K++ L N YE + + D RE+ L T++DL
Sbjct: 996 LQQQLTQAAQE---LAAEKE-KISVLQNNYEKSQETFKQLQSDFYG-RES-ELLATRQDL 1049
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
+E + Q + T ++ K +
Sbjct: 1050 -----KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA------KKEQQL 1098
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETCAEYLQERDEQCARLKK 877
+ + D + KE+ L ++EL + K + E+++ +C E + +E LK
Sbjct: 1099 QERCKALQDIQ----KEKSLK-EKELVNEKSKLAEIEEIKCRQEKEITKLNEE----LKS 1149
Query: 878 EKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
KL ++++NLK+ Q+ QQ +E Q K + +++ N ++ D++ + E E
Sbjct: 1150 HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN-QQILKDQVKKEEE-EL 1207
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
K ++ +L ++K M+K E K + A + L K E + ++R
Sbjct: 1208 KKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
Query: 996 KELDEECE 1003
EL+++ +
Sbjct: 1265 SELEKQTD 1272
Score = 108 bits (260), Expect = 9e-23
Identities = 225/1043 (21%), Positives = 441/1043 (42%), Gaps = 116/1043 (11%)
Query: 55 ISCKMCQSLKESS----NEINLKLEKLSGELFDIKEQKSALEGKYQNLILE----TQTRD 106
+ C+ QS +S + I+++L + +KE+ S +E KYQ+L E Q R+
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 107 -------LLMSQIKSLEMENLTKD----------KEIKNL-TDSLKTKSKKINELQEEND 148
L S+I L + L + KE + L ++ L K +++ +LQ +
Sbjct: 404 EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463
Query: 149 TLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLK 208
L + E VT S L ++D K+ ++ Q+ + E + + + Q K
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQ--EQQALQQSTTAKLREAQNDLEQVLRQIGEK 521
Query: 209 ENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSE---LDAGREDCKELCEDFT- 264
+ IQ+L SK N S+ + Y KI + E L+ +E L ++ T
Sbjct: 522 DQKIQNLEALLQK--SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQ 579
Query: 265 ---SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
++KN E H+ +L +++ E A + ++ ++N L+ QL NESK+
Sbjct: 580 LTENVKNQSESHK-QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL--NESKEK 636
Query: 322 KDHID-RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+D + K +L AE T+ + N ++ Q L + ++ K+ L++
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQ---RADLQNHLDTAQNALQDKHQELNKITTQLDQV 693
Query: 381 TSELKSVNEKLASLNSQLIE-KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
T++L+ E + L S L E KE ++ +++ E+ I K E + E+
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSL----EQKTEELEG----QIKKLEADSLEVKAS 745
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL-SRTDYEIEKEKLRLETGTAK 498
+ L L+ R L+ DL + T L L + E+ S T +++K+ LE + K
Sbjct: 746 KEQALQDLQQQ--RQLNTDL--ELRATELSKQLEMEKEIVSSTRLDLQKKSEALE--SIK 799
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
F+TL + E K HEEL ++ V E + L E+
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 559 ALKIAIAKNEEKM---LSLSEKDNK--LTELVSTINGLKEENNSLK-SLNDVITREKETQ 612
+K ++K + + S EK+N+ ++ KE + L+ + + + +KE +
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQ 671
S LE+ + Q EL+ M+ ++ ++ + L+ N+ LK+
Sbjct: 917 KS-LEKEKEASHQLKLELNSMQEQLIQ--------AQNTLKQNEKEEQQLQGNINELKQS 967
Query: 672 CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
E+K + L E+ I +KT E++N++ +L + QE L EKE K++ L N YE
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKT-ELENKLQQQLTQAAQE---LAAEKE-KISVLQNNYE 1022
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
+ + D RE+ L T++DL +E + Q +
Sbjct: 1023 KSQETFKQLQSDF-YGRES-ELLATRQDL-----KSVEEKLSLAQEDLISNRNQIGNQNK 1075
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
T ++ K + + + D + KE+ L ++EL + K
Sbjct: 1076 LIQELKTAKATLEQ------DSAKKEQQLQERCKALQDIQ----KEKSLK-EKELVNEKS 1124
Query: 850 RYKELDD-ECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFA 906
+ E+++ +C E + +E LK KL ++++NLK+ Q+ QQ +E Q K
Sbjct: 1125 KLAEIEEIKCRQEKEITKLNEE----LKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE---ELRYKKQDLKNTVTKMQKA 963
+ +++ N ++ D++ + E K + + K + E++ K+ +K K
Sbjct: 1181 SLKAAVEQEKRN-QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
Query: 964 MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAK 1023
+ T ++ +KE + + + EL+++ +L E ++ +++ + L E
Sbjct: 1240 TMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERC 1299
Query: 1024 IALE-IVDKLSNQKVALEKQIES 1045
+ E ++KL + + L++++++
Sbjct: 1300 LKGEGEIEKLQTKVLELQRKLDN 1322
Score = 85.0 bits (201), Expect = 1e-15
Identities = 194/1028 (18%), Positives = 415/1028 (40%), Gaps = 73/1028 (7%)
Query: 84 IKEQKSALEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKIN- 141
+K++ ++ N+ LE + + L + K E + + + I L L +++
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDESKKFESQYASSEATISQLRSELSKGPQEVRV 285
Query: 142 ---ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK-IG 197
ELQ+ +++ L +N T ++NL K+ D K E ++ + + + K +
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 345
Query: 198 PKNICAQCKLKENLIQSLHIGYD---NTLSKLNRSISDSNTSTRYNK--ICTLQSELDAG 252
+ + ++ E + +H+ KL +S+ T ++ K LQ + +
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK 405
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV----KVMSEIKRNLNS 308
+ +L + + + L L + +L E + ++ + + +++++ L+
Sbjct: 406 EQHGLQLQSEINQLHSKL-LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 309 LSEQLIN--NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEI 366
L EQL S + + +D+ K + TT+ + E N + + + E
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA-KLRE--AQNDLEQVLRQIGEK 521
Query: 367 LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVT--I 424
+K ++ L + + + ++ L +++ E +L +E+ H + VT
Sbjct: 522 DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLT 581
Query: 425 DIVKKENEL-KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE-LSRTD 482
+ VK ++E K+ ++ + K + D+ L + L L E +S+ D
Sbjct: 582 ENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
Query: 483 YEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD 541
+I+ K +L L AK + L+ A N ++ H+EL K+ +++D
Sbjct: 642 IQIKAKTELLLSAEAAKTAQRADLQ---------NHLDTAQNALQDKHQELNKI-TTQLD 691
Query: 542 ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL 601
+ A L + E L+ + + +EK LSL +K +L + K E +SL+
Sbjct: 692 QVTAKL---QDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK-----KLEADSLE-- 741
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ KE +L++ Q+ ++ + M + +S+
Sbjct: 742 ---VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 662 LEQNLALKEQCEEKTRDCSRLEINIK-THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
++ +E+ + +D L K HE+ + LQK E + L E T
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQL-TTQKDLVEGRIAELESDIRTEQTATVX 779
++L+ ++LK K+ + + A+ L T K+L ++E+ ++ ++
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
L +N K + + +I+ + S Q K+++ +
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS-EQKKKQIEA 977
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
Q EL + EL+++ + + L + ++ A +KEK+S+ Q ++ Q
Sbjct: 978 LQGELKIAVLQKTELENKLQ---QQLTQAAQELA-AEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK--RLMKTIEELRYKKQDLKNTV 957
+ + +++ + T +D ++ + D +N+ K I+EL+ K L+
Sbjct: 1034 DFYGRESEL-LATRQDLKSVEE-KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091
Query: 958 TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE-ECETCAEYLKQREEQC 1016
K ++ +++ K ++ + K K L++ EL K + E++E +C E K EE
Sbjct: 1092 AKKEQQLQERCKALQDIQ-KEKSLKE--KELVNEKSKLAEIEEIKCRQEKEITKLNEE-- 1146
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI--TDVM 1074
LK K LE + +++N K A + I+ ++ A +NQQI V
Sbjct: 1147 --LKSHK--LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE-KRNQQILKDQVK 1201
Query: 1075 KENQKLKK 1082
KE ++LKK
Sbjct: 1202 KEEEELKK 1209
Score = 78.2 bits (184), Expect = 2e-13
Identities = 201/1069 (18%), Positives = 442/1069 (41%), Gaps = 81/1069 (7%)
Query: 51 GTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMS 110
G +T S QSL++ +LE+ E F+IK+ K E K L T+ D+
Sbjct: 128 GLVTDSSAELQSLEQ-------QLEEAQTENFNIKQMKDLFEQKAAQLA--TEIADIKSK 178
Query: 111 QIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
+ + + K + LT+ L ++ I +L+ E L +E+V +V
Sbjct: 179 YDEERSLREAAEQK-VTRLTEELNKEATVIQDLKTE--LLQRPGIEDVAVLKKELVQVQT 235
Query: 171 LKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNT---LSKLN 227
L N ++ + EKL +ES+ K + ++ + + L L G + +L
Sbjct: 236 LMDNMTLERER--ESEKLKDESK-KFESQYASSEATISQ-LRSELSKGPQEVRVYVQELQ 291
Query: 228 RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE 287
+ S N T+ N+ TL L +D +L E N + + N+ L +K +
Sbjct: 292 KLKSSVNELTQKNQ--TLTENLLKKEQDYTKLEEKH----NEESVSKKNIQATLHQKDLD 345
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV 347
+ +++ + + R LSE+ ++K K+ + ++ L AEF
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEK--GEATQKLKEELSEV-ETKYQHLKAEFKQLQQQR 402
Query: 348 FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI 407
E + + Q +++++ K + + L E LK +L+S +L++KE
Sbjct: 403 EEKEQHGL--QLQSEINQLHSKLLETERQLGEAHGRLKE-QRQLSS--EKLMDKEQQVAD 457
Query: 408 LRIQKERIHE-ISSAVT--------IDIVKKENELKEILTKECL-KLSKLKIDIPRDLDQ 457
L+++ R+ E + VT +D K++++ ++ L + KL + + D+ + L Q
Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+KI L +AL+ + + + + E E+E L + + +
Sbjct: 518 IGEKDQKIQNL-EALLQKSKENISLLEKEREDLYAKIQAGEG-----------ETAVLNQ 565
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
L+E ++ +L +E+T+L ++ +++ ++ + L +++ K + ++++LSL
Sbjct: 566 LQEKNH---TLQDEVTQLTENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 578 DNKLT-------ELVSTIN-GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFE 629
N+L E VS ++ +K + L S T ++ + L+ + ++ E
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKHQE 682
Query: 630 LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH 689
L+K+ + K E+ L+L+++ EE +LE +
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD-SLE 741
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKR-DYDAAVKDLESSREA 748
K ++ Q ++ Q+Q+ D +L + +K E+ + + R D + LES ++
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +K +++ L + + + T +D
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD- 860
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYK-ELDD---ECETCAEY 864
+ K+ DS K S S + E + K +L ++ +LK + + ++++ E + +
Sbjct: 861 -KLSKVSDSLKNSKSEF-EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
L++ E +LK E S+++Q+ + ++ + E+Q + + + +
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
A ++K + K ++L Q+L K+ Y K + F+ + +
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 985 KAELEELKQRYKELDEECETCAEYL----KQREEQCKRLKEAKIALEIVDKLSNQK-VAL 1039
++EL +Q K ++E+ E L Q Q K ++E K A +++ S +K L
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDV-MKENQKLKKMNAKL 1087
+++ ++L + S + + +I ++ ++ +++ K+N +L
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Score = 62.9 bits (146), Expect = 6e-09
Identities = 160/839 (19%), Positives = 335/839 (39%), Gaps = 76/839 (9%)
Query: 246 QSELDAGREDCKELCEDFTSIKNHLE---LHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+S L R+D L ++ ++ L+ + + +L++ G + E K ++++
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ-EAKPDGLVTDS 133
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF-----EILMDNIIN 357
L SL +QL E++ +I + KD L A+ T D+ E +
Sbjct: 134 SAELQSLEQQL--EEAQTENFNIKQMKD-LFEQKAAQLATEIADIKSKYDEERSLREAAE 190
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER--- 414
+ L E L K V DL + + E +A L +L++ + + + +++ER
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGI-EDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 415 -IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
+ + S E + ++ ++ ++++ + ++L + + ++T L
Sbjct: 250 KLKDESKKFESQYASSEATISQLRSELSKGPQEVRVYV-QELQKLKSSVNELTQKNQTLT 308
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
DY +EK E+ + K + L + + +H EL+
Sbjct: 309 ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS 368
Query: 534 KLYKS--KVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTIN 589
+ ++ K+ E + + + L E L+ + E+ L L + N+L ++L+ T
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 590 GLKEENNSLKSLNDVITR---EKETQASELERSCQVIKQ-------NGFELDKMKADILM 639
L E + LK + + +KE Q ++L+ +++ N EL
Sbjct: 429 QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
EA++ LEQ L Q EK + LE ++ ++ + +
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDLEQVL---RQIGEKDQKIQNLEALLQKSKENISLLEKE 545
Query: 700 IMRLQKQIQEDDKLFIEKETK-LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
L +IQ E ET LN+L K L+ + +++++ E+ Q Q++L
Sbjct: 546 REDLYAKIQAG-----EGETAVLNQLQEKNHTLQDEVTQLTENVKNQSESHKQ--AQENL 598
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
+ ++ E ++ +R Q + ++ L K
Sbjct: 599 HD-QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK-------EKVSQLDIQIKAKTEL 650
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-- 876
S ++ + L+ L + Q L D + ++ + + LQ++ E C++L+
Sbjct: 651 LLSAEAAKTAQRADLQNHLDTAQNALQDKHQELNKITTQLDQVTAKLQDKQEHCSQLESH 710
Query: 877 ----KEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
KEK LSLEQ+ L+ QI+ + +A +V + ++ +L +++ D
Sbjct: 711 LKEYKEKYLSLEQKTEELEGQIK-----KLEADSLEVKASKEQALQDLQQ--QRQLNTDL 763
Query: 932 EV---EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
E+ E +K+L E + + DL+ ++ +K TK+++E + +++ E
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS--- 820
Query: 989 EELKQRYKELDEECETCAEYLK----QREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQ 1042
+E K +++EL+ +T L+ ++E L K L ++ D L N K EK+
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Score = 41.9 bits (94), Expect = 0.012
Identities = 83/406 (20%), Positives = 164/406 (40%), Gaps = 41/406 (10%)
Query: 32 SKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSAL 91
S + +I+ Q N +K + + + LK+SS + ++E L GEL QK+ L
Sbjct: 935 SMQEQLIQAQ-NTLKQNEKEEQQLQGNI-NELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 92 EGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE-IKNL-------TDSLKTKSKKINEL 143
E K Q + + + S+ N K +E K L L + + +
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLK-----------KNNECLTQKCIDLEKLVNES 192
+E+ ++ N + N NK + +LK K + L ++C L+ + +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI--QK 1110
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
E + K + + K K I+ + + ++KLN + S+ +I L+
Sbjct: 1111 EKSLKEKELVNE-KSKLAEIEEIKCRQEKEITKLNEELK-SHKLESIKEITNLKDAKQLL 1168
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE----NNEFETKAVKVMSEIKRNLNS 308
+ EL S+K +E + N + D+ E EF K K+ SEIK
Sbjct: 1169 IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG 1228
Query: 309 LSEQLINNESKKS------KDHI----DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ + NE+K + +++ ++ S V + E T L +++ +
Sbjct: 1229 MKKH-EENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-QLIEKEN 403
Q + +LE+ K +G++ + +++ + KL + + Q + +EN
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAVQELGREN 1333
Score = 35.5 bits (78), Expect = 1.1
Identities = 40/173 (23%), Positives = 85/173 (49%), Gaps = 13/173 (7%)
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL-EDCKAELEELKQRYKE 997
L + +++L+ ++ K +++K +EKY ++ EAK L D AEL+ L+Q+
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ-EAKPDGLVTDSSAELQSLEQQL-- 144
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS------NQKVALEKQIESLSNTPV 1051
EE +T +KQ ++ ++ K A++A EI D S + + A E+++ L+
Sbjct: 145 --EEAQTENFNIKQMKDLFEQ-KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN 201
Query: 1052 SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENE 1104
+T+ + ++Q I DV ++L ++ + + +R + ++E
Sbjct: 202 KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
>X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (1151
AA) protein.
Length = 1151
Score = 109 bits (263), Expect = 4e-23
Identities = 221/1111 (19%), Positives = 460/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 98 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 151
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 152 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 211
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 212 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 267
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 268 KRKLEGDLKLTQESIMDLENDKQQLEERLK-KKDFELNALNARIEDEQALG--SQLQKKL 324
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 325 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 383
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 384 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 443
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 444 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 500
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 501 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 559
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 560 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 618
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 619 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 666
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 667 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 725
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 726 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 784
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 785 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 841
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 842 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 897
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K D+E +E +Q Q L +K ++ +S L+ ++
Sbjct: 898 QAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 957
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 958 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1015
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1016 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1069
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1070 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1126
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1127 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1151
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 63 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 115
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 116 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 174
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 175 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 230
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 231 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 279
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 280 ESIMDLENDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 339
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + + + + ELE + +++ G +
Sbjct: 340 AERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 378
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 379 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 437
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 438 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 497
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 498 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 546
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 547 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 606
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 607 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 659
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 660 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 717
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 718 NKNLQEEISDLTE 730
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 62 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 121
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 122 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 179
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 180 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 233
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 234 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLE 293
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 294 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 331
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 51 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 99
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 100 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 150
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 53 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 112
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 113 NLADAEERCDQLIKNKIQLEAKVKEMN 139
>M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 108 bits (259), Expect = 1e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 1109 KELQARIEELEEELESERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1681
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1742 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1800 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1911 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1935
Score = 58.4 bits (135), Expect = 1e-07
Identities = 142/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 899
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 900 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 959 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 1014
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 1015 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 1063
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
S ++ + + + + ELE + +++ G +
Sbjct: 1124 SERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 1162
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 1221
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 1330
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1443
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1444 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1502 NKNLQEEISDLTE 1514
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 835 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 883
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 934
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 108 bits (259), Expect = 1e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 1109 KELQARIEELEEELESERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1681
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1742 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1800 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1911 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1935
Score = 58.4 bits (135), Expect = 1e-07
Identities = 142/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 899
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 900 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 959 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 1014
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 1015 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 1063
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
S ++ + + + + ELE + +++ G +
Sbjct: 1124 SERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 1162
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 1221
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 1330
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1443
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1444 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1502 NKNLQEEISDLTE 1514
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 835 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 883
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 934
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein.
Length = 2663
Score = 107 bits (257), Expect = 2e-22
Identities = 228/1086 (20%), Positives = 462/1086 (42%), Gaps = 118/1086 (10%)
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+I+ + ++L Y NL+L+ + + + EME K+K + ++L+ K+KK E
Sbjct: 495 NIESELNSLRADYDNLVLDYE-----QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQE 549
Query: 143 LQ--EENDTLSNLI----MENVTESDNLNKEVDDLKKNNECL--TQKCIDLEKLVN-ESE 193
+Q E L NL+ + N + L+ +V+ L++ + + Q+ ID +KL N + +
Sbjct: 550 MQLIHEISNLKNLVKHREVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMD 609
Query: 194 NKIGPKNICAQCKLKENLIQSLHIGYDNT-----LSKLNRSISD--SNTSTRY----NKI 242
++I ++K+ L + + D L N + + +T Y N I
Sbjct: 610 LSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDI 669
Query: 243 CTLQSELDAGRE---DC-KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
QS+L+A ++ D KEL F I L + + DL L + ++
Sbjct: 670 QLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKEL 729
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
E++ N E ++ +E K ++R + + + TS + L +++K
Sbjct: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEK--DKLFSEVVHK 787
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + +LE+ K + DL S KS +++ + + ++ E ++ + ER+++
Sbjct: 788 -ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI------------T 466
++ + K ++ L + T+ K +L+ + R++ + L +++ T
Sbjct: 847 IVNLSKEAQKFDSSLGALKTELSYKTQELQ-EKTREVQERLNEMEQLKEQLENRDSPLQT 905
Query: 467 ILFDALITQYELSRTDYEI-----EKEKLR-LETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+ + + +L +T E+ EK+ L+ L+ DT E+
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 521 AHNEVKSL--HEELTKLYKSKVDEN-NANLNLIKILSEEIDALK---IAIAKNEE----- 569
N ++SL H+E KSK+ E + NL++ + E D + + I K ++
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 570 -KMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ L+ KDN++ E I L +E N L+ + + + EKE ++L+ + ++ +N
Sbjct: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE 1085
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINIK 687
EL ++ D L E+N A+K++ E +R C RL E+ K
Sbjct: 1086 EL-RLLGDELKKQQEIVAQ---------------EKNHAIKKE-GELSRTCDRLAEVEEK 1128
Query: 688 THEKTAEIQNR--MIMRLQKQIQEDDKLFIEKETKLNELTNK---YEALKRDYDAAVKDL 742
EK+ ++Q + ++ +Q+++ E K E E NEL NK E ++ + + L
Sbjct: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKL 1188
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+ E V +T ++ +++ EL+ TE+
Sbjct: 1189 NENYEEVKSITKERKVLK----ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHL 1244
Query: 803 DENRDLGENPKLDDSPKRS-ISVISDSEVS--QLKERL--LSCQQE-LDDLKE--RYKEL 854
E+++ + + S K + I D E S +L+E + L +QE L ++K+ +E
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKKVSETQET 1304
Query: 855 DDECETCAEYLQERDE-QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD 913
+E E E +D AR++ E+L L ++ +E+I++ K A+
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
D H + + + A++++++ K + L K++D N TK+ ME++ KD
Sbjct: 1365 HDQLKEH--IRETL---AKIQESQ--SKQEQSLNMKEKD--NETTKIVSEMEQFKPKDSA 1415
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEE---CETCAEYLKQREEQCKRLKEAKIA--LEI 1028
E+ L+E K + +E + E L+ +Q K + +A LE
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET 1475
Query: 1029 VDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN-----QKLKKM 1083
++L L++Q E+++ V+ S + Q + I D ++ +K +++
Sbjct: 1476 EEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQL 1535
Query: 1084 NAKLIT 1089
N K I+
Sbjct: 1536 NIKQIS 1541
Score = 104 bits (249), Expect = 2e-21
Identities = 213/1014 (21%), Positives = 422/1014 (41%), Gaps = 79/1014 (7%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
L E ++KE+ L Y+ + + Q L SQ+++ + + +KE+++ + + TK
Sbjct: 644 LRSENLELKEKMKELATTYKQMENDIQ---LYQSQLEAKKKMQVDLEKELQSAFNEI-TK 699
Query: 137 SKKINELQEENDTLSNLIMEN-VTE-SDNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
+ + + D L NL +E +T+ LNKEV++ NE L ++ I L SE
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEE----NEALREEVILL------SEL 749
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI--SDSNTSTRYNKICTLQSELDAG 252
K P + K ++ + LHI + KL + +S +I + +L
Sbjct: 750 KSLPSEVERLRKEIQDKSEELHI-ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808
Query: 253 REDCKELCEDFTSIKN-HLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
+ + K ++F + K H++ E M L+E N E + K + +L +L
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDF-EQKYKMVLEENERMNQEIVNLS-KEAQKFDSSLGALKT 866
Query: 312 QL---INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
+L +K+++ +R + E + L E I K Q L+E+ +
Sbjct: 867 ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEV-K 925
Query: 369 KYTKVQGDLNECTSELKSVNEKLAS-----LNSQLIEKE---NACNILRIQKERIHEISS 420
T+ + DL + L+ ++L S +N + +E NA L+ +E I+ + S
Sbjct: 926 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985
Query: 421 AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY-ELS 479
++ ++ + N E T E + K+ + D QDL A T+ D + E
Sbjct: 986 KISEEVSR--NLHMEENTGETKDEFQQKM-VGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1042
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
R + + +EK L+ + T+E E++ L +EL K +
Sbjct: 1043 RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN-QEELRLLGDELKKQQEIV 1101
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
E N + LS D L K +EK L EK +L + ++ ++++ N ++
Sbjct: 1102 AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
Query: 600 SL-NDVITREKETQASELER--SCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+L N++ +E + E ER Q + +N E+ + + +
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
Query: 657 EAKSLLEQNLALKEQCE-----EKTRDCSRLEINIKTHEKTAEIQNRMIM-----RLQKQ 706
+ + L KE+ + K + E+ EKTA+I N + +LQ++
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 707 I---QEDDKLF--IEKETKLNELTNKYEALKRDYDAAVKDLES-SREAVNQLTTQKDLVE 760
I E+ +L ++K ++ E N+ E L + KD + +R + +L + E
Sbjct: 1282 IPVLHEEQELLPNVKKVSETQETMNELELLTE--QSTTKDSTTLARIEMERLRLNEKFQE 1339
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
+ E++S + + ++ + +
Sbjct: 1340 SQ-EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 821 SISVISDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ ++S+ E + K+ LL + E+ L +R +E DE ++ A +E+D+ RL++
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA---KEKDD-LQRLQEVL 1454
Query: 880 LSLEQQV-SNLKEQIRTQQPVERQAKFADVAVNTDEDWAN-LHSVVVDRMSYDAEVEK-- 935
S Q+ N+KE + E + K A + E+ N L + ++ + + ++K
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514
Query: 936 ---NKRLMKTIEELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
N +L I+E+ K++ L ++++Q+ + + + + +AK L+ ++++ EL
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQLNIKQISEVQENVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
R +E EE + +K++EE KR++EA + +E N K + K ES
Sbjct: 1575 TNRLQESQEEIQI---MIKEKEEM-KRVQEA-LQIERDQLKENTKEIVAKMKES 1623
Score = 83.8 bits (198), Expect = 3e-15
Identities = 185/928 (19%), Positives = 371/928 (39%), Gaps = 88/928 (9%)
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
KEI +L L+ S + E D L+ L+ E N+++++L + +T +
Sbjct: 350 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTR--MLVTSSSL 407
Query: 184 DLEKLVNESE-----------NKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
L++ + NK+ N Q + N+ H N L +++ S+
Sbjct: 408 TLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVC- 466
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
S + N + TL SE++ E+ S N L N+ +D ++ E E E
Sbjct: 467 SESDVFSNTLDTL-SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEME 525
Query: 293 TKA-----VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV 347
K + ++R E + +E K+ + ++++ L+ E ++ +++
Sbjct: 526 LKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV-KHREVYNQDLENEL-SSKVEL 583
Query: 348 FEILMDNIINKYQIDLDEILEKYTKVQGDLN---ECTSELKSVNEKLASLNSQLIEKENA 404
D I K Q +D +K ++ DL+ E + K + + L + ++ +
Sbjct: 584 LREKEDQ-IKKLQEYIDS--QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
Query: 405 CNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
LR + + E + + EN++ ++ + K+++D+ ++L K
Sbjct: 641 SAFLRSENLELKEKMKELATTYKQMENDI-QLYQSQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+T L D + + L + E+E + L+ K V +E
Sbjct: 700 LTSLIDGKVPKDLL--CNLELEGKITDLQKELNKEVEENEALREEVILL---------SE 748
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TE 583
+KSL E+ +L K D++ + I++ E D L + E ++ L E+ K +
Sbjct: 749 LKSLPSEVERLRKEIQDKSEE----LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDD 804
Query: 584 LVSTINGLK---EENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
L +T + K +E + K+L+ ++ + E ER Q I E K + +
Sbjct: 805 LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL 864
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
E + L + LKEQ E + +E EKT +
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVE-----REKTL-----IT 914
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
+LQ+ ++E L EK+ +L E+L+ + D D+ + VN ++ +
Sbjct: 915 EKLQQTLEEVKTLTQEKD----DLKQLQESLQIERDQLKSDI---HDTVNMNIDTQEQLR 967
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
+ L+ T T F + + + L+ +
Sbjct: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027
Query: 821 SISV-ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+++ + D+E+ + + ++ S QE ++L++ + + E E L+E E +E+
Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE-NQEE 1086
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
L L L ++++ QQ + Q K + A+ + + S DR+ AEVE ++L
Sbjct: 1087 LRL------LGDELKKQQEIVAQEK--NHAIKKEGEL----SRTCDRL---AEVE--EKL 1129
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
+ ++L+ K+Q L N +Q+ M + KK E E + EL++ + LE ++ EL
Sbjct: 1130 KEKSQQLQEKQQQLLN----VQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELA 1185
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALE 1027
++ E +K ++ K LKE + + E
Sbjct: 1186 QKLNENYEEVKSITKERKVLKELQKSFE 1213
Score = 80.6 bits (190), Expect = 3e-14
Identities = 198/998 (19%), Positives = 414/998 (41%), Gaps = 77/998 (7%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
LKE + + L G + +I + + L+ K + I ++ I L K
Sbjct: 1205 LKELQKSFETERDHLRGYIREI--EATGLQTKEELKIAHIHLKEH-QETIDELRRSVSEK 1261
Query: 123 DKEIKNLTDSLKTKSK---KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN---E 176
+I N D K+ +K +I L EE + L N+ + V+E+ E++ L + + +
Sbjct: 1262 TAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV--KKVSETQETMNELELLTEQSTTKD 1319
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLI---QSLHIGYDNTLSKLNRSISDS 233
T I++E+L + + + I + K ++NL ++L + +D + +++
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI 1379
Query: 234 NTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
S + E D E F + L E M + L ++L E+++ E
Sbjct: 1380 QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM-LGLSKRLQESHD-EM 1437
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
K+V ++ K +L L E ++ +ES + K++I K+ + L+ E +
Sbjct: 1438 KSV---AKEKDDLQRLQE-VLQSESDQLKENI---KEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
IN+ +++L E + + +Q +L+++N+KL + ++ EKE NI +
Sbjct: 1491 ETINELRVNLSEKETEISTIQ-------KQLEAINDKLQNKIQEIYEKEEQLNI-----K 1538
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
+I E+ ++ +K+ E ++ + +++ L + + ++I I+ +
Sbjct: 1539 QISEVQE--NVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE---SQEEIQIM---IK 1590
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
+ E+ R ++ E+ +L+ T + V T A NE + E++
Sbjct: 1591 EKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT---AVNETQ---EKMC 1644
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
++ K LNL I +E I +I + +N E+M S++++ + L + T LK
Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQI-LHENLEEMRSVTKERDDLRSVEET---LKV 1700
Query: 594 ENNSLK-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXX 652
E + LK +L + ITR+ E Q EL+ +K++ +DK++ +
Sbjct: 1701 ERDQLKENLRETITRDLEKQ-EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759
Query: 653 XXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK 712
D K+ Q+L ++E+ + I + + +QK ++ +
Sbjct: 1760 HSNDALKA---QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816
Query: 713 LFIEKETKLNELTNKYEALKRDYDAA---VKDLESSREAV--NQLTTQKDLVEG-RIA-E 765
EK +L ++ LK+D + V ++E ++ + LT K +E +A E
Sbjct: 1817 KLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQE 1876
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD-ENRDLGENPKLDDSPKRSISV 824
L ++ ++ + + + RDL +L + R +S
Sbjct: 1877 LHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA--RMLSK 1934
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQ 884
V +L+E++ ++ D+++ + DE + + LQ+++ Q R+ KE +++
Sbjct: 1935 EHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRV-KEDVNMSH 1993
Query: 885 QVSNLKEQIRTQQPVERQAKF-ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ N EQ++ Q K D T + +L + + D E+ + K +K
Sbjct: 1994 KKINEMEQLKKQFEPNYLCKCEMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKME 2052
Query: 944 EE--LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE- 1000
+ + ++ + Q EK D + E C + ++EL +RY E+D+
Sbjct: 2053 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLMESLREKC-SRIKELLKRYSEMDDH 2111
Query: 1001 -ECETCAEYLKQREEQCKR-LKEAKIALEIVDKLSNQK 1036
EC ++E + R +K+ K L V K+ ++
Sbjct: 2112 YECLNRLSLDLEKEIEFHRIMKKLKYVLSYVTKIKEEQ 2149
Score = 78.6 bits (185), Expect = 1e-13
Identities = 161/785 (20%), Positives = 331/785 (42%), Gaps = 85/785 (10%)
Query: 276 NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK-DHIDRYKDSLLA 334
N+ ++DE + ++ + + +SEI+ N + +L+N E+ +S+ + + D+L
Sbjct: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNP---ATKLLNQENIESELNSLRADYDNL-- 510
Query: 335 VLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASL 394
VLD E T + E+ + K +D E LE+ TK E++ ++E +++L
Sbjct: 511 VLDYEQLRTEKEEMELKLKE---KNDLDEFEALERKTKKD-------QEMQLIHE-ISNL 559
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK-ECLKLSKLKIDIPR 453
+ L++ N ++ +E+SS V + + +KE+++K++ + KL +K+D+
Sbjct: 560 KN-LVKHREVYN-----QDLENELSSKVEL-LREKEDQIKKLQEYIDSQKLENIKMDLSY 612
Query: 454 DLDQ-DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
L+ + P K T LFDA + R + E L L+ +
Sbjct: 613 SLESIEDPKQMKQT-LFDAETVALDAKRESAFLRSENLELKEKMKELAT----------- 660
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVD---ENNANLNLIKILSEEIDALKIAIAKNEE 569
T ++ N+++ +L K +VD E + N I L+ ID K +
Sbjct: 661 ----TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG------KVPK 710
Query: 570 KMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFE 629
+L E + K+T+L +N EEN +L+ ++ E ++ SE+ER + I+ E
Sbjct: 711 DLLCNLELEGKITDLQKELNKEVEENEALRE-EVILLSELKSLPSEVERLRKEIQDKSEE 769
Query: 630 L-------DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
L DK+ ++++ D+ + + ++ +
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
E K + E N+ I+ L K+ Q+ D +T+L+ T + + R+
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV------- 882
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+E +N++ K+ +E R + L++ + E+T
Sbjct: 883 ---QERLNEMEQLKEQLENRDSPLQT-VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQ 938
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE-----LDDE 857
+ + + K D ++++ + ++ E L Q+ ++ LK + E L E
Sbjct: 939 ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA 917
E E E ++ + K++ + L ++ + +E+Q K + +E
Sbjct: 999 -ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQ 1057
Query: 918 NLHSVVVDRMSYDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
L SV+ ++ ++++N + ++ EELR +LK + A EK KE E
Sbjct: 1058 MLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV--AQEKNHAIKKEGEL 1115
Query: 977 KRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQ 1035
R D AE+EE LK++ ++L E+ + ++ E K++ E + + ++L N+
Sbjct: 1116 SR--TCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE---NLKNELKNK 1170
Query: 1036 KVALE 1040
++ LE
Sbjct: 1171 ELTLE 1175
Score = 75.4 bits (177), Expect = 1e-12
Identities = 224/1086 (20%), Positives = 454/1086 (41%), Gaps = 140/1086 (12%)
Query: 33 KNDNIIETQSNPIKLQDSGTITISCKMCQ---SLKESSNEINLKLEKLSGELFDIKE--- 86
+N N ++ K +DS +I KM + L+ES EI + +++ E+ ++E
Sbjct: 1545 ENVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKE-EMKRVQEALQ 1603
Query: 87 -QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK--EIKNLTDSLKTKSKKINEL 143
++ L+ + ++ + + Q + N T++K EI++L + +T+ + +
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
+ EN L+ ++ EN+ E ++ KE DDL+ E L + L++ + E+ +++
Sbjct: 1664 ETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT----RDLEK 1719
Query: 204 QCKLKENLIQSLHI-GYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCED 262
Q +LK I +H+ + T+ KL +S+ + N+I +Q +L+ + K +D
Sbjct: 1720 QEELK---IVHMHLKEHQETIDKLRGIVSE-----KTNEISNMQKDLEHSNDALK--AQD 1769
Query: 263 FTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK-KS 321
+K EL +M L E E K ++SE L+++ + L N+ +K +
Sbjct: 1770 ---LKIQEELRIAHM------HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEI-LMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
K + + L L + T V E+ + I + L ++ + + +L+E
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHEN 1880
Query: 381 TSELKSV---NEKLASLNSQL-IEKENACNILRIQKERIHEISSAV-TIDIVKKENELKE 435
E+KSV + L + L +E++ L+ K R EI + T ++ KE+ KE
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEH--KE 1938
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG 495
+ K K+S+ I I D+ +DL K EL + E++K++L+L
Sbjct: 1939 TVDKLREKISEKTIQI-SDIQKDLDKSKD------------ELQKKIQELQKKELQL--- 1982
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
+ + NE++ L ++ Y K + + N L K L E
Sbjct: 1983 -------------LRVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEMD--NFQLTKKLHE 2027
Query: 556 EIDALKIAIAKNEEKMLSLSEK-DNKLTELVSTINGL---KEENNSLKSLNDVITREKET 611
++ ++I +AK +++ + E + + ++T+ + +N+ +K +++ ++
Sbjct: 2028 SLEEIRI-VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH 2086
Query: 612 QASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQ 671
L C IK EL K +++ D + L +L L+++
Sbjct: 2087 LMESLREKCSRIK----ELLKRYSEM-----------------DDHYECLNRLSLDLEKE 2125
Query: 672 CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL 731
E R +L+ + K E Q+ I + + FI++ K EL K + L
Sbjct: 2126 IEFH-RIMKKLKYVLSYVTKIKEEQHECINKFEMD-------FIDEVEKQKELLIKIQHL 2177
Query: 732 KRDYDAAVKDLESSREAVN-QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
++D D ++L + N L ++ L + +E S I+TE +
Sbjct: 2178 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPS-IKTEFQQVLSNRKEMTQFLEE 2236
Query: 791 XXXXXXXXXTFGDENRDLGENPKL----DDSPKRSISVISDSEVSQLKERLLS--CQQEL 844
+N EN ++ + R I+++++S + + +S +Q+L
Sbjct: 2237 WLNTRFDIEKL--KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDL 2294
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
LKE+ ++L +T L + + K V++ Q+ T++ E +
Sbjct: 2295 KSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNK---NPHVTSRATQLTTEKIRELENS 2351
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAEVEKN--KRLMKTIEELRYKKQDLKNTVTKMQK 962
+ E + S ++ +M + EV + +L + E + K T+ +Q
Sbjct: 2352 LHE----AKESAMHKESKII-KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQD 2406
Query: 963 AMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA 1022
+ K KE E + +++ K +LE++K KE ++E ++ ++E + L+E
Sbjct: 2407 KVALGAKPYKE-EIEDLKMKLVKIDLEKMKNA-KEFEKEISATKATVEYQKEVIRLLRE- 2463
Query: 1023 KIALEIVDKLSNQKVALEKQIESLSNTP-VSNSTMYVATGSAIVQNQQITDVMKENQKLK 1081
L + A + + S P SN + GS IVQN + + E+ +L+
Sbjct: 2464 --------NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLE 2515
Query: 1082 KMNAKL 1087
K +KL
Sbjct: 2516 KEISKL 2521
Score = 60.9 bits (141), Expect = 2e-08
Identities = 116/550 (21%), Positives = 226/550 (41%), Gaps = 39/550 (7%)
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD-NKLTELVSTINGLKEENNSLKSLNDV 604
++NL++ + E + + + + +LSE + N T+L++ N ++ E NSL++ D
Sbjct: 454 SINLLREIDESVCSESDVFSNTLD---TLSEIEWNPATKLLNQEN-IESELNSLRADYDN 509
Query: 605 ITREKETQASELERSCQVIKQNGFELD-------KMKADILMXXXXXXXXXXXXXXXXDE 657
+ + E +E E +K+ +LD K K D M +
Sbjct: 510 LVLDYEQLRTEKEEMELKLKEKN-DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHREV 568
Query: 658 AKSLLEQNLALK-EQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
LE L+ K E EK +L+ I + +K I +M + + ED K
Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQEYIDS-QKLENI--KMDLSYSLESIEDPKQM-- 623
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
K+T + T +A + ++LE +E + +L T +E I +S + ++
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLEL-KEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD----DSPKRSISVISDSEVSQ 832
V G +DL N +L+ D K + ++E +
Sbjct: 683 QVDLEKELQSAFNEITKLTSLID--GKVPKDLLCNLELEGKITDLQKELNKEVEENEALR 740
Query: 833 LKERLLSCQQELDDLKERY-KELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
+ LLS + L ER KE+ D+ E E+D +L E + E +V L E
Sbjct: 741 EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD----KLFSEVVHKESRVQGLLE 796
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKK 950
+I + + A +TD+++ N ++ +D Y +E+N+R+ + I L +
Sbjct: 797 EIGKTK--DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 951 QDLKNTV----TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
Q +++ T++ ++ +K +E + + E+E K +LE + ++ E
Sbjct: 855 QKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLIT 914
Query: 1007 EYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
E L+Q E+ K L + K L ++ + L ++ L+ I N + ++
Sbjct: 915 EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK 974
Query: 1066 QNQQITDVMK 1075
Q+Q+ + +K
Sbjct: 975 QHQETINTLK 984
Score = 58.4 bits (135), Expect = 1e-07
Identities = 45/168 (26%), Positives = 87/168 (51%), Gaps = 7/168 (4%)
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
R YD V ++L EE+ K ++ KN + + + A+E+ TKKD+E + E+ + K
Sbjct: 504 RADYDNLVLDYEQLRTEKEEMELKLKE-KNDLDEFE-ALERKTKKDQEMQLIH-EISNLK 560
Query: 986 AELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
++ + ++L+ E + E L+++E+Q K+L+E + KL N K+ L +ES
Sbjct: 561 NLVKHREVYNQDLENELSSKVELLREKEDQIKKLQEYIDS----QKLENIKMDLSYSLES 616
Query: 1046 LSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ + T++ A A+ ++ + EN +LK+ +L T K+
Sbjct: 617 IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664
>EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 107 bits (257), Expect = 2e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1681
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1742 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1800 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1911 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1935
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 899
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 900 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 959 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 1014
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 1015 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 1063
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + + + + ELE + +++ G +
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 1162
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 1221
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 1330
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1443
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1444 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1502 NKNLQEEISDLTE 1514
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 835 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 883
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 934
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 107 bits (257), Expect = 2e-22
Identities = 213/1093 (19%), Positives = 447/1093 (40%), Gaps = 88/1093 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 884 QEKNDLQLQVQAEQDNLNDAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 937
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 938 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 997
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI------GPKN 200
L + + + +V+ L K+ L Q+ DLE + E E K+ +
Sbjct: 998 KKALQEAHQQALDDLQAEEDKVNTLSKSKVKLEQQVDDLEGSL-EQEKKVRMDLERAKRK 1056
Query: 201 ICAQCKLKENLIQSLH---IGYDNTLSKLNRSISDSNTSTRYNKICTLQ-----SELDAG 252
+ KL + I L + + L K I+ N+ ++ LQ E A
Sbjct: 1057 LEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQAR 1116
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ +E E + + +E +++ +L+E + E E A V E+ + + ++
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 313 LINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQIDLDEI-- 366
+ + + + H D AE G +L + ++ ++++++LD++
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
+E+ K + +L + + +++ ++ +L E + + N Q+ ++ + ++
Sbjct: 1236 NMEQIIKAKANLEKVS---RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELSRQ 1292
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ +KE + + LT+ L ++ D+ R L+++ A + + +L R YE
Sbjct: 1293 LEEKEALISQ-LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEE 1351
Query: 486 EKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
E E K L+ +KA ++T +A + L E KL + D
Sbjct: 1352 ETEAKAELQRVLSKA-----NSEVAQCRTKYET--DAIQRTEELEEAKKKLAQRLQDAEE 1404
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
A + + ++ K + E ++ E+ N + K++ N K L +
Sbjct: 1405 A-VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFDKILAEW 1458
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+ +E+Q SELE S + + EL K+K +E L EQ
Sbjct: 1459 KQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
Query: 665 -NLALKEQCE-EKTR---DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
K E EK R + +LE+ E A +++ L+ Q+ E +++ E E
Sbjct: 1518 LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL-EFNQIKAEIER 1576
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIAELESDIRTEQT 775
KL E + E KR++ V L++S +A N++ K +EG + E+E
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME-------- 1628
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ D L + + +D K +I+++ + + L+
Sbjct: 1629 --IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLLQA 1685
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + ++ + K D E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1686 ELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQSEV-- 1743
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQDLK 954
++ V+ + A A + + A +E+ K+ M +TI++L+++ + +
Sbjct: 1744 EEAVQECRNAEEKAKKAITHAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1803
Query: 955 NTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQRE 1013
Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q E
Sbjct: 1804 ------QIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTE 1857
Query: 1014 EQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDV 1073
E K L + ++VDKL + A ++Q E +N + + + + ++ D+
Sbjct: 1858 EDKKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1914
Query: 1074 MKENQKLKKMNAK 1086
+ ++ K+ AK
Sbjct: 1915 AE--SQVNKLRAK 1925
Score = 51.6 bits (118), Expect = 2e-05
Identities = 57/248 (22%), Positives = 118/248 (47%), Gaps = 34/248 (13%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQER 868
S ++ E++ +KE ++ L+ + R KEL++ + + AE L +
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K+ LE +V + E++ ++ E A+ +++ + L + D
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
A+VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE
Sbjct: 962 TLAKVEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1015
Query: 988 LEELKQRYK---ELDEECETCAEYLKQRE------EQCKRLKEA--KIALEIVDKLSNQK 1036
+++ K +L+++ + L+Q + E+ KR E K+ E + L N K
Sbjct: 1016 EDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 1037 VALEKQIE 1044
+ LE++++
Sbjct: 1076 LQLEEKLK 1083
Score = 50.4 bits (115), Expect = 3e-05
Identities = 54/220 (24%), Positives = 104/220 (47%), Gaps = 19/220 (8%)
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
A +KE +++++ +KE + + ++ + V++ +++ L DAE
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
E+ +L+K K L+ V +M + +E + + E AK+++LED E ELK
Sbjct: 905 -ERCDQLIKN-------KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED---ECSELK 953
Query: 993 QRYKELDEECETCAEYLKQR---EEQCKRLKEAKIAL-EIVDKLSNQKVAL-EKQIESLS 1047
K++D+ T A+ K++ E + K L E L EI+ KL+ +K AL E ++L
Sbjct: 954 ---KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1010
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + + S + QQ+ D+ ++ KK+ L
Sbjct: 1011 DLQAEEDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050
Score = 38.3 bits (85), Expect = 0.15
Identities = 24/97 (24%), Positives = 51/97 (52%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ + + ++ EA+RKELE+ ++ L Q +L + + +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEE---KMVSLLQEKNDLQLQVQAEQDN 899
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 900 LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 936
>BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 107 bits (257), Expect = 2e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1681
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1742 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1800 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1911 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1935
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 899
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 900 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 959 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 1014
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 1015 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 1063
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + + + + ELE + +++ G +
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 1162
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 1221
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 1330
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1443
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1444 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1502 NKNLQEEISDLTE 1514
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 835 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 883
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 934
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 107 bits (257), Expect = 2e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1681
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1742 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1800 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1911 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1935
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 899
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 900 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 959 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 1014
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 1015 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 1063
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + + + + ELE + +++ G +
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 1162
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 1221
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 1330
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1443
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1444 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1502 NKNLQEEISDLTE 1514
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 835 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 883
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 934
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypeptide 7,
cardiac muscle, beta variant protein.
Length = 1574
Score = 107 bits (257), Expect = 2e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 521 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 574
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 575 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 634
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 635 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 690
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 691 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 747
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 748 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 806
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 807 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 866
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 867 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 923
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 924 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 982
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 983 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1041
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1042 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1089
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1090 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1148
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1149 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1207
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1208 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1264
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1265 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1320
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1321 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1380
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1381 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1438
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1439 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1492
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1493 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1549
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1550 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1574
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 486 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 538
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 539 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 597
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 598 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 653
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 654 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 702
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 703 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 762
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + + + + ELE + +++ G +
Sbjct: 763 AERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 801
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 802 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 860
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 861 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 920
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 921 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 969
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 970 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1029
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1030 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1082
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1083 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1140
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1141 NKNLQEEISDLTE 1153
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 485 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 544
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 545 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 602
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 603 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 656
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 657 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 716
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 717 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 754
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 474 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 522
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 523 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 573
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 476 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 535
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 536 NLADAEERCDQLIKNKIQLEAKVKEMN 562
>X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy
chain protein.
Length = 1934
Score = 107 bits (256), Expect = 3e-22
Identities = 220/1111 (19%), Positives = 458/1111 (41%), Gaps = 97/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K +N+ E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRNVEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A E+ +
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSCQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV--ERRNNL 1680
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K D E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1681 QAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1740
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1741 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1798
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1799 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1852
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1853 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1909
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1910 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1934
Score = 57.6 bits (133), Expect = 2e-07
Identities = 63/280 (22%), Positives = 131/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE + ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ N +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRNVEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.7B protein.
Length = 1179
Score = 107 bits (256), Expect = 3e-22
Identities = 220/1111 (19%), Positives = 459/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 126 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 179
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 180 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 239
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 240 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 295
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 296 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 352
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A V E+ +
Sbjct: 353 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKR 411
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 412 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 471
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 472 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQTEN 528
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 529 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 587
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 588 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 646
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 647 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 694
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 695 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 753
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 754 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 812
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 813 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 869
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 870 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 925
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 926 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 985
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 986 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1043
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1044 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1097
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1098 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1154
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1155 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1179
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/733 (19%), Positives = 291/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 91 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 143
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 144 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 202
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 203 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 258
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 259 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 307
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 308 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 367
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + + + + ELE + +++ G +
Sbjct: 368 AERTARAKVEKLRSDLSRELEEISERLEEAG---------------------GATSVQIE 406
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 407 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 465
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 466 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQ 525
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 526 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 574
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 575 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 634
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 635 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 687
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 688 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 745
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 746 NKNLQEEISDLTE 758
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 90 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 149
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 150 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 207
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 208 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 261
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 262 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 321
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 322 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 359
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 79 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 127
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 128 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 178
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 81 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 140
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 141 NLADAEERCDQLIKNKIQLEAKVKEMN 167
>BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6,
cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
protein.
Length = 1939
Score = 106 bits (254), Expect = 5e-22
Identities = 213/1097 (19%), Positives = 443/1097 (40%), Gaps = 96/1097 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 884 QEKNDLQLQVQAEQDNLNDAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 937
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 938 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 997
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI------GPKN 200
L + + + +V+ L K+ L Q+ DLE + E E K+ +
Sbjct: 998 KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSL-EQEKKVRMDLERAKRK 1056
Query: 201 ICAQCKLKENLIQSLH---IGYDNTLSKLNRSISDSNTSTRYNKICTLQ-----SELDAG 252
+ KL + I L + + L K I+ N+ ++ LQ E A
Sbjct: 1057 LEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQAR 1116
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ +E E + + +E +++ +L+E + E E A V E+ + + ++
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 313 LINNESKKSKDHIDRYKDSLLAVLD--AEFGTT--SLDVFEILMDNIINKYQIDLDEI-- 366
+ + + + H D AE G +L + ++ ++++++LD++
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
+E+ K + +L + + +++ ++ +L E + + N Q+ ++ + +
Sbjct: 1236 NMEQIIKAKANLEKVS---RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQ 1292
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ +KE + + LT+ L ++ D+ R L+++ A + + +L R YE
Sbjct: 1293 LEEKEALISQ-LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEE 1351
Query: 486 EKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
E E K L+ +KA EE K L + L ++ V+ N
Sbjct: 1352 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA-VEAVN 1410
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
A + ++ K + E ++ E+ N + K++ N K L +
Sbjct: 1411 AKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFDKILAEW 1458
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+ +E+Q SELE S + + EL K+K +E L EQ
Sbjct: 1459 KQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
Query: 665 -NLALKEQCE-EKTR---DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
K E EK R + +LE+ E A +++ L+ Q+ E +++ E E
Sbjct: 1518 LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL-EFNQIKAEIER 1576
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIAELESDIRTEQT 775
KL E + E KR++ V L++S +A N++ K +EG + E+E
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME-------- 1628
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ D L + + +D K +I+++ + + L+
Sbjct: 1629 --IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLLQA 1685
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + ++ + K + E +E +Q Q L +K +E ++ L+ ++
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV-- 1743
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEELRYKKQD-- 952
++ V+ + A D A + + A +E+ K+ M+ TI++L+++ +
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1803
Query: 953 ---LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
LK ++QK + + + E EA++K + + + ++R KEL
Sbjct: 1804 QIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL----------T 1853
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
Q EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 YQTEEDKKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEE 1910
Query: 1070 ITDVMKENQKLKKMNAK 1086
D+ + ++ K+ AK
Sbjct: 1911 RADIAE--SQVNKLRAK 1925
Score = 51.2 bits (117), Expect = 2e-05
Identities = 55/220 (25%), Positives = 105/220 (47%), Gaps = 19/220 (8%)
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
A +KE +++++ +KE + + ++ + V++ +++ L DAE
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
E+ +L+K K L+ V +M + +E + + E AK+++LED E ELK
Sbjct: 905 -ERCDQLIKN-------KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED---ECSELK 953
Query: 993 QRYKELDEECETCAEYLKQR---EEQCKRLKEAKIAL-EIVDKLSNQKVAL-EKQIESLS 1047
K++D+ T A+ K++ E + K L E L EI+ KL+ +K AL E ++L
Sbjct: 954 ---KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1010
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ V + + S + QQ+ D+ ++ KK+ L
Sbjct: 1011 DLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050
Score = 50.4 bits (115), Expect = 3e-05
Identities = 56/248 (22%), Positives = 117/248 (47%), Gaps = 34/248 (13%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQER 868
S ++ E++ +KE ++ L+ + R KEL++ + + AE L +
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K+ LE +V + E++ ++ E A+ +++ + L + D
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
A+VEK K + K ++L + + + + K TK+ K EA ++ L+D + E
Sbjct: 962 TLAKVEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 988 LEELKQRYK---ELDEECETCAEYLKQRE------EQCKRLKEA--KIALEIVDKLSNQK 1036
+++ K +L+++ + L+Q + E+ KR E K+ E + L N K
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 1037 VALEKQIE 1044
+ LE++++
Sbjct: 1076 LQLEEKLK 1083
Score = 38.3 bits (85), Expect = 0.15
Identities = 24/97 (24%), Positives = 51/97 (52%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ + + ++ EA+RKELE+ ++ L Q +L + + +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEE---KMVSLLQEKNDLQLQVQAEQDN 899
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 900 LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 936
>AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 105 bits (252), Expect = 9e-22
Identities = 219/1111 (19%), Positives = 458/1111 (41%), Gaps = 96/1111 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 882 QEKNDLQLQVQAEQDNLADAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 935
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L K + L E RD+ L + +E E + ++KNLT+ + TK
Sbjct: 936 LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK +++LQ E D ++ L V L ++VDDL+ + E + +DLE+
Sbjct: 996 KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
E + K+ ++I K+ L + L D L+ LN I D +++
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLK-KKDFELNALNARIEDEQALG--SQLQKKL 1108
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
EL A E+ +E E + + +E +++ +L+E + E E A E+ +
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSCQIEMNKKR 1167
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQID 362
+ +++ + + + H D AE G +L + ++ ++++++
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 363 LDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
LD++ +E+ K + +L + +++ +++ S+ E + + N L Q+ ++ +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
++ + +KE + + LT+ L ++ D+ R L++++ A + + +L
Sbjct: 1285 GELSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 480 RTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
R YE E E K L+ +KA EE K L + L + +
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EE 1402
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
V+ NA + ++ K + E ++ E+ N + K++ N
Sbjct: 1403 AVEAVNAKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFD 1450
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K L + + +E+Q SELE S + + EL K+K +E
Sbjct: 1451 KILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 659 KSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
L EQ + + E K + ++E+ E A +++ L+ Q+ E +++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQI 1568
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E E KL E + E KR++ V L++S +A + + V+ ++E D+
Sbjct: 1569 KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK---KKMEGDLNEM 1625
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ + D L + + +D K +I+++ + + L
Sbjct: 1626 E---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLL 1681
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L + ++ + K + E +E +Q Q L +K ++ +S L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQD 952
++ V+ + A D A + + A +E+ K+ M +TI++L+++ +
Sbjct: 1742 --EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQ 1011
+ Q A++ K+ ++ EA+ +ELE + +AE + + K + + E Q
Sbjct: 1800 AE------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 TEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D+ + ++ K+ AK I G G N E
Sbjct: 1911 DIAE--SQVNKLRAKSRDI----GTKGLNEE 1935
Score = 54.0 bits (124), Expect = 3e-06
Identities = 62/280 (22%), Positives = 129/280 (46%), Gaps = 29/280 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQERDEQC 872
+ E++ +KE ++ L+ + R KEL++ + + AE L + +E+C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+L K K+ LE +V + E++ ++ E A+ +++ + L + D A+
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAELEEL 991
VEK K + K ++L + + + + K TK+ K EA ++ L+D +AE +++
Sbjct: 964 VEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 992 KQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLS 1047
K +L+++ + L+Q ++ L+ AK LE KL+ + + LE + L
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
A + I Q + ++ +KLK++ A++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARI 1115
Score = 54.0 bits (124), Expect = 3e-06
Identities = 143/733 (19%), Positives = 289/733 (39%), Gaps = 73/733 (9%)
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K M+ +K L E L +E+++ + ++ ++++L E L V + DN+
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKE-----LEEKMVSLLQ-EKNDLQLQV-QAEQDNLA 899
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ + D++++ +++ + E L+ E A L ++ + E+ C+ L+ + +
Sbjct: 900 DAEE-RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ V + EN++K LT+E L ++ + ++ AH++ D L +
Sbjct: 959 LTLAKVEKEKHATENKVKN-LTEEMAGLDEIIAKLTKEKKALQEAHQQA---LDDLQAEE 1014
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ T + K K++LE + V D LE A + L +L
Sbjct: 1015 DKVNT---LTKAKVKLE----QQVDDLEGSLEQEKKVRMD-LERAK---RKLEGDLKLTQ 1063
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+S +D N L + L ++ L A+ E++ S+ KL EL + I L+EE
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ ++ + E S+L R + I + E +
Sbjct: 1124 AERTARAKV----EKLRSDLSRELEEISERLEE-----------------AGGATSCQIE 1162
Query: 657 EAKSLLEQNLALKEQCEEKT--RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
K + ++ EE T + + + K + AE+ I LQ+ Q+ +K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKLEKEK 1221
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + +L+++T+ E + + K + + +N+ ++ + + + +L S Q
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
T T+ + DL +L++ K + L
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR--QLEEEVKAK---------NALA 1330
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-KEKLSLEQQVSNLKEQI 893
L S + + D L+E+Y+E + L + + + A+ + K + Q+ L+E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 894 RTQQPVERQAKFADVAVNT-----DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++A+ A AVN ++ L + + D M +VE++ ++
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---VDVERSNAAAAALD---- 1443
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
KKQ +N + + +KY + E E+ +KE EL +LK Y+E E ET
Sbjct: 1444 KKQ--RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 1009 LKQREEQCKRLKE 1021
K +E+ L E
Sbjct: 1502 NKNLQEEISDLTE 1514
Score = 41.9 bits (94), Expect = 0.012
Identities = 32/111 (28%), Positives = 60/111 (54%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E + + +K T++++A+EK EA+RKELE+ ++ L Q
Sbjct: 835 KIKPLLKSAEREK-EMASMKEEFTRLKEALEKS-------EARRKELEE---KMVSLLQE 883
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + + L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 934
Score = 33.5 bits (73), Expect = 4.3
Identities = 21/87 (24%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K +++KE + ++E K LE+ + R KEL+E+ + + + Q + ++
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 896
Query: 1022 -AKIALEIVDKLSNQKVALEKQIESLS 1047
A E D+L K+ LE +++ ++
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMN 923
>Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 104 bits (250), Expect = 2e-21
Identities = 213/1097 (19%), Positives = 442/1097 (40%), Gaps = 96/1097 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ L D +E +
Sbjct: 884 QEKNDLQLQVQAEQDNLNDAE------ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE 937
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 938 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 997
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI------GPKN 200
L + + + +V+ L K+ L Q+ DLE + E E K+ +
Sbjct: 998 KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSL-EQEKKVRMDLERAKRK 1056
Query: 201 ICAQCKLKENLIQSLH---IGYDNTLSKLNRSISDSNTSTRYNKICTLQ-----SELDAG 252
+ KL + I L + + L K I+ N+ + LQ E A
Sbjct: 1057 LEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQAR 1116
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ +E E + + +E +++ +L+E + E E A V E+ + + ++
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEE-ISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 313 LINNESKKSKDHIDRYKDSLLAVLD--AEFGTT--SLDVFEILMDNIINKYQIDLDEI-- 366
+ + + + H D AE G +L + ++ ++++++LD++
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
+E+ K + +L + + +++ ++ +L E + + N Q+ ++ + +
Sbjct: 1236 NMEQIIKAKANLEKVS---RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQ 1292
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ +KE + + LT+ L ++ D+ R L+++ A + + +L R YE
Sbjct: 1293 LEEKEALISQ-LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEE 1351
Query: 486 EKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
E E K L+ +KA EE K L + L ++ V+ N
Sbjct: 1352 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA-VEAVN 1410
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
A + ++ K + E ++ E+ N + K++ N K L +
Sbjct: 1411 AKCS-------SLEKTKHRLQNEIEDLMVDVERSNAAAAALD-----KKQRNFDKILAEW 1458
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+ +E+Q SELE S + + EL K+K +E L EQ
Sbjct: 1459 KQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
Query: 665 -NLALKEQCE-EKTR---DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
K E EK R + +LE+ E A +++ L+ Q+ E +++ E E
Sbjct: 1518 LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL-EFNQIKAEIER 1576
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIAELESDIRTEQT 775
KL E + E KR++ V L++S +A N++ K +EG + E+E
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME-------- 1628
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ D L + + +D K +I+++ + + L+
Sbjct: 1629 --IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV-ERRNNLLQA 1685
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + ++ + K + E +E +Q Q L +K +E ++ L+ ++
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV-- 1743
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEELRYKKQD-- 952
++ V+ + A D A + + A +E+ K+ M+ TI++L+++ +
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1803
Query: 953 ---LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
LK ++QK + + + E EA++K + + + ++R KEL
Sbjct: 1804 QIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL----------T 1853
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
Q EE K L + ++VDKL + A ++Q E +N + + + + ++
Sbjct: 1854 YQTEEDKKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEE 1910
Query: 1070 ITDVMKENQKLKKMNAK 1086
D+ + ++ K+ AK
Sbjct: 1911 RADIAE--SQVNKLRAK 1925
Score = 52.0 bits (119), Expect = 1e-05
Identities = 63/292 (21%), Positives = 136/292 (46%), Gaps = 38/292 (13%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDD------------ECETCAEY--LQER 868
S ++ E++ +KE ++ L+ + R KEL++ + + AE L +
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K+ LE +V + E++ ++ E A+ +++ + L + D
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNERLEDEE--EMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
A+VEK K + K ++L + + + + K TK+ K EA ++ L+D + E
Sbjct: 962 TLAKVEKEKHATEN------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 988 LEELKQRYK---ELDEECETCAEYLKQRE------EQCKRLKEA--KIALEIVDKLSNQK 1036
+++ K +L+++ + L+Q + E+ KR E K+ E + L N K
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ-KLKKMNAKL 1087
+ LE++++ ++ + A+ Q+ +KENQ +++++ +L
Sbjct: 1076 LQLEEKLKK-KEFDINQQNSKIEDEQALA--LQLQKKLKENQARIEELEEEL 1124
Score = 38.3 bits (85), Expect = 0.15
Identities = 24/97 (24%), Positives = 51/97 (52%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ + + ++ EA+RKELE+ ++ L Q +L + + +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEE---KMVSLLQEKNDLQLQVQAEQDN 899
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C +L + KI LE K N+++ E+++ +
Sbjct: 900 LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 936
>AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein
protein.
Length = 2585
Score = 102 bits (245), Expect = 6e-21
Identities = 213/1015 (20%), Positives = 425/1015 (41%), Gaps = 81/1015 (7%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
L E ++KE+ L Y+ + + Q L SQ+++ + + +KE+++ + + TK
Sbjct: 624 LRSENLELKEKMKELATTYKQMENDIQ---LYQSQLEAKKKMQVDLEKELQSAFNEI-TK 679
Query: 137 SKKINELQEENDTLSNLIMEN-VTE-SDNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
+ + + D L NL +E +T+ LNKEV++ NE L ++ I L SE
Sbjct: 680 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEE----NEALREEVILL------SEL 729
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI--SDSNTSTRYNKICTLQSELDAG 252
K P + K ++ + LHI + KL + +S +I + +L
Sbjct: 730 KSLPSEVERLRKEIQDKSEELHI-ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 788
Query: 253 REDCKELCEDFTSIKN-HLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
+ + K ++F + K H++ E M L+E N E + K + +L +L
Sbjct: 789 QSNYKSTDQEFQNFKTLHMDF-EQKYKMVLEENERMNQEIVNLS-KEAQKFDSSLGALKT 846
Query: 312 QL---INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
+L +K+++ +R + E ++L E I K Q L+E+ +
Sbjct: 847 ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV-K 905
Query: 369 KYTKVQGDLNECTSELKSVNEKLAS-----LNSQLIEKE---NACNILRIQKERIHEISS 420
T+ + DL + L+ ++L S +N + +E NA L+ +E I+ + S
Sbjct: 906 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 965
Query: 421 AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY-ELS 479
++ ++ + N E T E + K+ + D QDL A T+ D + E
Sbjct: 966 KISEEVSR--NLHMEENTGETKDEFQQKM-VGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1022
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
R + + +EK L+ + T+E E++ L +EL K +
Sbjct: 1023 RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN-QEELRLLGDELKKQQEIV 1081
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
E N + LS D L K +EK L EK +L + ++ ++++ N ++
Sbjct: 1082 AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1141
Query: 600 SL-NDVITREKETQASELER--SCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+L N++ +E + E ER Q + +N E+ + + +
Sbjct: 1142 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1201
Query: 657 EAKSLLEQNLALKEQCE-----EKTRDCSRLEINIKTHEKTAEIQNRMIM-----RLQKQ 706
+ + L KE+ + K + E+ EKTA+I N + +LQ++
Sbjct: 1202 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1261
Query: 707 I---QEDDKLF--IEKETKLNELTNKYEALKRDYDAAVKDLES-SREAVNQLTTQKDLVE 760
I E+ +L +++ ++ E N+ E L + KD + +R + +L + E
Sbjct: 1262 IPVLHEEQELLPNVKEVSETQETMNELELLTE--QSTTKDSTTLARIEMERLRLNEKFQE 1319
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
+ E++S + + ++ + +
Sbjct: 1320 SQ-EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1378
Query: 821 SISVISDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ ++S+ E + K+ LL + E+ L +R +E DE ++ A +E+D+ RL++
Sbjct: 1379 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA---KEKDD-LQRLQEVL 1434
Query: 880 LSLEQQV-SNLKEQIRTQQPVERQAKFADVAVNTDEDWAN-LHSVVVDRMSYDAEVEK-- 935
S Q+ N+KE + E + K A + E+ N L + ++ + + ++K
Sbjct: 1435 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1494
Query: 936 ---NKRLMKTIEELRYKKQDLKN--TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
N +L I+E+ Y+K++ N ++++Q+ + + + + +AK L+ ++++ E
Sbjct: 1495 EAINDKLQNKIQEI-YEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLE 1553
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L R +E EE + +K++EE KR++EA + +E N K + K ES
Sbjct: 1554 LTNRLQESQEEIQI---MIKEKEEM-KRVQEA-LQIERDQLKENTKEIVAKMKES 1603
Score = 91.9 bits (218), Expect = 1e-17
Identities = 220/1045 (21%), Positives = 445/1045 (42%), Gaps = 100/1045 (9%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSAL-EGKYQNLILET---QTRDLLMSQIKSLEMENL 120
++ ++ LE L I KS + E +NL +E +T+D ++ ++ +
Sbjct: 941 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1000
Query: 121 TKDKEIKNLTDSLKT-----KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
+ K + LT +K + +KI L +E + L ++ + E + L DLK+N
Sbjct: 1001 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT---DLKENI 1057
Query: 176 ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT 235
E + +L L +E + + + I AQ K + + L+++ + + +
Sbjct: 1058 EMTIENQEELRLLGDELKKQ---QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1114
Query: 236 ST--RYNKICTLQSELDAGREDCKELCEDFTSIKN-HLEL-HEPNMTMDLDEKLGENNEF 291
+ ++ +Q E+ ++ E+ +KN L L H ++L +KL EN E
Sbjct: 1115 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1174
Query: 292 E---TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
TK KV+ E++++ + + L + + ++ +A + + ++D
Sbjct: 1175 VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID-- 1232
Query: 349 EILMDNIINKYQIDLDEILEK-YTKVQGDL------NECTSELKSVNEKLASLNS-QLIE 400
E+ QI + LEK +TK+Q ++ E +K V+E ++N +L+
Sbjct: 1233 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLT 1292
Query: 401 KEN----ACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLD 456
+++ + + RI+ ER+ + + + E+K LTKE L +K + D
Sbjct: 1293 EQSTTKDSTTLARIEMERLR-----LNEKFQESQEEIKS-LTKERDNLKTIKEALEVKHD 1346
Query: 457 QDLPAHKKITI--LFDALITQYE-LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXX 513
Q L H + T+ + ++ Q + L+ + + E K+ E K
Sbjct: 1347 Q-LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG 1405
Query: 514 XFDTLEEAHNEVKSLHEE------LTKLYKSKVDENNANLNLI--KILSEEIDALKIA-- 563
L+E+H+E+KS+ +E L ++ +S+ D+ N+ I K L E + LK+A
Sbjct: 1406 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE-EELKVAHC 1464
Query: 564 -IAKNEEKM----LSLSEKDNKLTELVSTINGLKEE-NNSLKSLNDVITREKETQASELE 617
+ + EE + ++LSEK+ +++ + + + ++ N ++ + + + Q SE++
Sbjct: 1465 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1524
Query: 618 RSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR 677
+KQ E K K L E E + +KE+ EE R
Sbjct: 1525 EKVNELKQFK-EHRKAKDSALQSIESKMLELTNRLQESQE-----EIQIMIKEK-EEMKR 1577
Query: 678 DCSRLEINI-KTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY---EALKR 733
L+I + E T EI +M K+ QE + F+ K T +NE K E LK
Sbjct: 1578 VQEALQIERDQLKENTKEIVAKM-----KESQEKEYQFL-KMTAVNETQEKMCEIEHLKE 1631
Query: 734 DYDAAVKDLESSREAVNQLTT--QKDLVEGR-IAELESDIRT-EQTATVXXXXXXXXXXX 789
++ +LE+ +LT ++L E R + + D+R+ E+T V
Sbjct: 1632 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1691
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
+ L E+ + D + +S +E+S +++ L + D LK
Sbjct: 1692 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE-KTNEISNMQKDL---EHSNDALKA 1747
Query: 850 RYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA 909
+ ++ +E +L+E+ E +L+ ++SN+++ + + Q K ++
Sbjct: 1748 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN-AKLQEKIQELK 1806
Query: 910 VNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK----TIEELRYKK----QDLKNTVTKMQ 961
N + L V + +E+E+ K+ +K T+ +L + Q L + +M+
Sbjct: 1807 AN-EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK 1865
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
M++ + E + E + K L+E K R E+ +E +T K+ +E +L+E
Sbjct: 1866 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1925
Query: 1022 AKIALEIVDKLSNQKVALEKQIESL 1046
KI+ + + ++S+ + L+K + L
Sbjct: 1926 -KISEKTI-QISDIQKDLDKSKDEL 1948
Score = 87.8 bits (208), Expect = 2e-16
Identities = 193/983 (19%), Positives = 400/983 (40%), Gaps = 80/983 (8%)
Query: 76 KLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
K GEL ++ + +E K + + Q + + ++ E K EI+NL + LK
Sbjct: 1090 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKN 1149
Query: 136 KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
K + ++ E L+ + EN E ++ KE LK+ + + L + E E
Sbjct: 1150 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE-- 1207
Query: 196 IGPKNICAQCKLKENL-IQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGR 253
+ KE L I +H+ + T+ +L RS+S+ + L+ +
Sbjct: 1208 ------ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ--DLEKSHTKLQ 1259
Query: 254 EDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
E+ L E+ + N E+ E TM+ E L E + TK ++ I+ L+E+
Sbjct: 1260 EEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST--TKDSTTLARIEMERLRLNEKF 1317
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV 373
ES++ + + +D+L + +A E+ D + + L +I E +K
Sbjct: 1318 --QESQEEIKSLTKERDNLKTIKEA---------LEVKHDQLKEHIRETLAKIQESQSKQ 1366
Query: 374 QGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ----KERIHEISSAVTIDIVKK 429
+ LN E + K+ S Q K++A + I+ +R+ E + + K+
Sbjct: 1367 EQSLN--MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK-SVAKE 1423
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE--------LSRT 481
+++L+ + + +LK +I + + L +++ + L Q E LS
Sbjct: 1424 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1483
Query: 482 DYEIEKEKLRLETGTAKA---VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
+ EI + +LE K + ++E NE+K E +
Sbjct: 1484 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA 1543
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEK-------MLSLSEKDNKLTELVSTINGL 591
+ L L L E + ++I I + EE + + E+V+ +
Sbjct: 1544 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1603
Query: 592 KEENNSLKSLNDVI-TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
+E+ + V T+EK + L+ + K N ++ +
Sbjct: 1604 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1663
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
D+ +S+ E ++Q +E R+ ++ EK E++ + M L++ +
Sbjct: 1664 VTKERDDLRSVEETLKVERDQLKENLRETITRDL-----EKQEELKI-VHMHLKEHQETI 1717
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAA-VKDL---ESSREAVNQLTTQKDLVEGRIAEL 766
DKL K NE++N + L+ DA +DL E R A L Q++ ++ ++ +
Sbjct: 1718 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID-KLRGI 1776
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
S+ +T++ + + +E++ + ++++ K+ +S +
Sbjct: 1777 VSE-KTDKLSNMQKDLENSNAKLQEKIQELKA----NEHQLITLKKDVNETQKK-VSEME 1830
Query: 827 DSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
+ Q+K++ L+ + E+++L K L + E ++ERD + KL +Q
Sbjct: 1831 QLK-KQIKDQSLTLSKLEIENLNLAQK-LHENLEEMKSVMKERDNLRRVEETLKLERDQL 1888
Query: 886 VSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN-LHSVVVDRMSYDAEVEKNKRLMKTIE 944
+L+E ++++ K A + ++ + L + ++ ++++K+ L K+ +
Sbjct: 1889 KESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKD--LDKSKD 1946
Query: 945 ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
EL+ KKQD +N K +K + D + E C + ++EL +RY E+D+ E
Sbjct: 1947 ELQ-KKQDRQNHQVKPEKRL----LSDGQQHLTESLREKC-SRIKELLKRYSEMDDHYEC 2000
Query: 1005 CAEYLKQREEQCKRLKEAKIALE 1027
E++ + KE + ++
Sbjct: 2001 LNRLSLDLEKEIEFQKELSMRVK 2023
Score = 82.6 bits (195), Expect = 7e-15
Identities = 204/1049 (19%), Positives = 417/1049 (39%), Gaps = 124/1049 (11%)
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
KEI +L L+ S + E D L+ L+ E N+++++L + +T +
Sbjct: 355 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTR--MLVTSSSL 412
Query: 184 DLEKLVNESE-----------NKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI-- 230
L++ + NK+ N Q + N+ H N L +++ S+
Sbjct: 413 TLQQELKAKRKRRVTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCS 472
Query: 231 -SD--SNT-----------STRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
SD SNT +T+ ++SEL++ R D L D+ ++ E
Sbjct: 473 ESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKE----E 528
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES--KKSKDHIDRYK----- 329
M + L EK + +EFE K + + L+S E L E KK +++ID K
Sbjct: 529 MELKLKEK-NDLDEFEALERKTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLENIK 587
Query: 330 ----DSLLAVLD-AEFGTTSLDVFEILMD-----NIINKYQIDLDEILEK----YTKVQG 375
SL ++ D + T D + +D + ++L E +++ Y +++
Sbjct: 588 MDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 647
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNIL------RIQKERI--HEISSAVTIDIV 427
D+ S+L++ + L +L N L ++ K+ + E+ +T D+
Sbjct: 648 DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKIT-DLQ 706
Query: 428 K---KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL-ITQYELSRTDY 483
K KE E E L +E + LS+LK +P ++++ K+I + L I E +
Sbjct: 707 KELNKEVEENEALREEVILLSELK-SLPSEVER---LRKEIQDKSEELHIITSEKDKLFS 762
Query: 484 EIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDEN 543
E+ ++ R++ G + + T +E N K+LH + + YK ++EN
Sbjct: 763 EVVHKESRVQ-GLLEEIGKTKDDLATTQSNYKSTDQEFQN-FKTLHMDFEQKYKMVLEEN 820
Query: 544 NANLNLIKILSEEIDAL--KIAIAKNE--EKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
I LS+E + K E K L EK ++ E ++ + LKE+ +
Sbjct: 821 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 880
Query: 600 SLNDVITREKETQASELERSCQVIK------------QNGFEL--DKMKADILMXXXXXX 645
S + REK +L+++ + +K Q ++ D++K+DI
Sbjct: 881 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 940
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
+ K E LK + E+ +E N T E E Q +M+ +K
Sbjct: 941 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN--TGETKDEFQQKMVGIDKK 998
Query: 706 Q-IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIA 764
Q ++ + + + K NE+ + +R + +++ ++ + + +K+ ++ +
Sbjct: 999 QDLEAKNTQTLTADVKDNEIIEQ----QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1054
Query: 765 E-LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E +E I ++ + G+ +R ++++ K
Sbjct: 1055 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE--- 1111
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
++ + +++LL+ Q+E+ +++++ E+ E L+ ++ ++ E+L L
Sbjct: 1112 --KSQQLQEKQQQLLNVQEEMSEMQKKINEI----ENLKNELKNKELTLEHMETERLELA 1165
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN------K 937
Q+++ E++++ + K + T+ D + ++ + E K
Sbjct: 1166 QKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1225
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+TI+ELR + + Q + +TK +E +E +EL KE
Sbjct: 1226 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE--------QELLPNVKE 1277
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
+ E ET E L+ EQ +A +++L + E Q E S T ++
Sbjct: 1278 VSETQETMNE-LELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1336
Query: 1058 VATGSAIVQNQQITDVMKENQKLKKMNAK 1086
+ + +Q + + K+++ +K
Sbjct: 1337 IKEALEVKHDQLKEHIRETLAKIQESQSK 1365
Score = 79.0 bits (186), Expect = 9e-14
Identities = 210/1008 (20%), Positives = 415/1008 (41%), Gaps = 108/1008 (10%)
Query: 46 KLQDSGTITISCKMCQ---SLKESSNEINLKLEKLSGELFDIKE----QKSALEGKYQNL 98
K +DS +I KM + L+ES EI + +++ E+ ++E ++ L+ + +
Sbjct: 1538 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKE-EMKRVQEALQIERDQLKENTKEI 1596
Query: 99 ILETQTRDLLMSQIKSLEMENLTKDK--EIKNLTDSLKTKSKKINELQEENDTLSNLIME 156
+ + + Q + N T++K EI++L + +T+ + ++ EN L+ ++ E
Sbjct: 1597 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1656
Query: 157 NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLH 216
N+ E ++ KE DDL+ E L + L++ + E+ +++ Q +LK I +H
Sbjct: 1657 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT----RDLEKQEELK---IVHMH 1709
Query: 217 I-GYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEP 275
+ + T+ KL +S+ + N+I +Q +L+ + K +D +K EL
Sbjct: 1710 LKEHQETIDKLRGIVSE-----KTNEISNMQKDLEHSNDALK--AQD---LKIQEELRIA 1759
Query: 276 NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK-KSKDHIDRYKDSLLA 334
+M L E E K ++SE L+++ + L N+ +K + K + + L
Sbjct: 1760 HM------HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1813
Query: 335 VLDAEFGTTSLDVFEI-LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSV---NEK 390
L + T V E+ + I + L ++ + + L+E E+KSV +
Sbjct: 1814 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1873
Query: 391 LASLNSQL-IEKENACNILRIQKERIHEISSAV-TIDIVKKENELKEILTKECLKLSKLK 448
L + L +E++ L+ K R EI + T ++ KE+ KE + K K+S+
Sbjct: 1874 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEH--KETVDKLREKISEKT 1931
Query: 449 IDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXX--X 506
I I D+ +DL K D L Q + R +++++ EK L G
Sbjct: 1932 IQI-SDIQKDLDKSK------DEL--QKKQDRQNHQVKPEKRLLSDGQQHLTESLREKCS 1982
Query: 507 XXXXXXXXFDTLEEAHNEVKSLHEELTK---LYKSKVDENNANLNLIKILSEEIDALKIA 563
+ +++ + + L +L K K ANL+L + ++ I+ L A
Sbjct: 1983 RIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTA 2042
Query: 564 IAKNEEKMLSLSEKDNKLTELVSTINGLKEE-NNSLKSLN----DVITREKE--TQASEL 616
N+ + KL ++S + +KEE + S+ D + ++KE + L
Sbjct: 2043 ---NQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2099
Query: 617 ERSCQVIKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE- 674
++ C V + +L D+ + E + +L + + EE
Sbjct: 2100 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEW 2159
Query: 675 -KTR-DCSRLEINI-KTHEKTAEI----QNRMIMRLQKQIQ-EDDKLFIEKETK--LNEL 724
TR D +L+ I K +++ ++ NR+I + + + E+ I KE + L L
Sbjct: 2160 LNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL 2219
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLT--TQKDLVEGRIAELESD-IRTEQTATVXXX 781
K E L ++Y L S + VN T + V R +L ++ IR + +
Sbjct: 2220 KEKNEKLFKNYQTLKTSLASGAQ-VNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK 2278
Query: 782 XXXXXXXXXXXXXXXXXXTFGD----ENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
D + E+ K + K +I V+ D K
Sbjct: 2279 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAK--- 2335
Query: 838 LSCQQELDDLKERYKELD-DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
++E++DLK + ++D ++ + E+ +E A ++ +K + + L+E +R
Sbjct: 2336 -PYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQK----EVIRLLRENLRRS 2390
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
Q + + ++ +TD +N V+ K L+ E +R +K+
Sbjct: 2391 QQAQDTSVISE---HTDPQPSNKPLTCGGGSGI---VQNTKALILKSEHIRLEKE----- 2439
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKEL-EDCKAELEELKQRYKELDEECE 1003
++K+++ E+ K+ E + + L + K E +R CE
Sbjct: 2440 ISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2487
Score = 75.4 bits (177), Expect = 1e-12
Identities = 226/1079 (20%), Positives = 439/1079 (40%), Gaps = 122/1079 (11%)
Query: 30 AKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKL--SGELFDIK-E 86
AK + + QS +K +D+ T I +M Q + S + +++E L S L + E
Sbjct: 1357 AKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE 1416
Query: 87 QKSALEGK--YQNL--ILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
KS + K Q L +L++++ D L IK + ++L ++E+K LK + + INE
Sbjct: 1417 MKSVAKEKDDLQRLQEVLQSES-DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1475
Query: 143 LQ----EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
L+ E+ +S + + +D L ++ ++ + E K I V E N++
Sbjct: 1476 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE---VQEKVNEL-- 1530
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC-----TLQSELDAGR 253
K K K++ +QS+ ++L S + + + LQ E D +
Sbjct: 1531 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1590
Query: 254 EDCKELCEDFT-SIKNHLELHEPNMTMDLDEKLGE----NNEFETKAVK---VMSEIKRN 305
E+ KE+ S + + + + EK+ E +FET+ + + +E R
Sbjct: 1591 ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL 1650
Query: 306 LNSLSEQLINNES-KKSKDHIDRYKDSLLAVLDA-EFGTTSLDVFEILMDNIINKYQIDL 363
L E L S K +D + +++L D + ++ + + L
Sbjct: 1651 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1710
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEISSAV 422
E E K++G ++E T+E+ ++ + L N L ++ L+IQ+E RI +
Sbjct: 1711 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD-----LKIQEELRIAHMHLKE 1765
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIP------RDLDQDLPA--HKKITILFDALIT 474
+ + K L+ I++++ KLS ++ D+ ++ Q+L A H+ IT+ D T
Sbjct: 1766 QQETIDK---LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1822
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE-EAHNEVKSLHEELT 533
Q ++S E+E+ K +++ + LE E N + LHE L
Sbjct: 1823 QKKVS----EMEQLKKQIKDQSL----------------TLSKLEIENLNLAQKLHENLE 1862
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
++ KS + E + + + L E D LK ++ + + + L + +++ K ++S KE
Sbjct: 1863 EM-KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI-QQELKTARMLS-----KE 1915
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQN-GFELDKMKADILMXXXXXXXXXXXXX 652
++ L + I+ EK Q S++++ K + D+ +
Sbjct: 1916 HKETVDKLREKIS-EKTIQISDIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDGQQHLT 1974
Query: 653 XXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK------- 705
E S +++ L + ++ +RL +++ EK E Q + MR++
Sbjct: 1975 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDL---EKEIEFQKELSMRVKANLSLPYL 2031
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAE 765
Q + +KLF + E + LK K E E++N+ + D ++ +
Sbjct: 2032 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF--EMDFIDEVEKQ 2089
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI 825
E I+ + ++ E P + ++ +S
Sbjct: 2090 KELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLS-- 2147
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER-----------DEQCAR 874
+ E++Q E L+ + +++ LK ++ +D + R +E+ A
Sbjct: 2148 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2207
Query: 875 LKKEKLSLEQQVSNLKEQ----IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
+ KE EQ + +LKE+ + Q ++ T +D N H V +
Sbjct: 2208 ISKE---WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPH---VTSRATQ 2261
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
EK + L ++ E + ++ + KMQK +E + +AK E C LE+
Sbjct: 2262 LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC---LEK 2318
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
K+ + L ++ A+ K+ E K +K KI LE K+ N K EK+I + T
Sbjct: 2319 TKETIQVLQDKVALGAKPYKEEIEDLK-MKLVKIDLE---KMKNAK-EFEKEISATKAT 2372
Score = 72.5 bits (170), Expect = 8e-12
Identities = 150/741 (20%), Positives = 287/741 (38%), Gaps = 50/741 (6%)
Query: 369 KYTKVQGDLNECTSE---LKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
KY K +NE +++ LK +++ L QL E ++K+++ ++ +
Sbjct: 332 KYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDL- 390
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ K +NE E LT+ + S L L Q+L A +K + + L ++ ++Y
Sbjct: 391 LQKVQNEKIENLTRMLVTSSSLT------LQQELKAKRKRRVTW-CLGKINKMKNSNYAD 443
Query: 486 EKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH-EELTKLYKSKVDEN 543
+ + T T K D + + + TKL + E+
Sbjct: 444 QSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIES 503
Query: 544 NANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLND 603
N + +D ++ K EE L L EK N L E + K++ + S
Sbjct: 504 ELNSLRADYDNLVLDYEQLRTEK-EEMELKLKEK-NDLDEFEALERKTKKDQENELSSKV 561
Query: 604 VITREKETQASELERSCQVIKQNGFELDKMKA-----DILMXXXXXXXXXXXXXXXXDEA 658
+ REKE Q +L+ K ++D + D E+
Sbjct: 562 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 621
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ----EDDKLF 714
L +NL LKE+ +E ++E +I+ ++ E + +M + L+K++Q E KL
Sbjct: 622 AFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLT 681
Query: 715 ------IEKETKLN-ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
+ K+ N EL K L+++ + V++ E+ RE V L+ K L + L
Sbjct: 682 SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSL-PSEVERLR 740
Query: 768 SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+I+ + +E +G+ K D + +S +D
Sbjct: 741 KEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE---IGKT-KDDLATTQSNYKSTD 796
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
E K + +Q+ + E + ++ E ++ Q+ D LK E L +
Sbjct: 797 QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE---LSYKTQ 853
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
L+E+ R Q ER + + + + L +V ++ EK ++ ++ ++ L
Sbjct: 854 ELQEKTREVQ--ERLNEMEQLKEQLENRDSTLQTVEREKTLI---TEKLQQTLEEVKTLT 908
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
+K DLK +Q +E+ K + + D + +L + K+ E T
Sbjct: 909 QEKDDLKQLQESLQ--IERDQLKSDIHDTVNMNI-DTQEQLRNALESLKQHQETINTLKS 965
Query: 1008 YLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQN 1067
K EE + L + E D+ + V ++K+ + L T V I Q
Sbjct: 966 --KISEEVSRNLHMEENTGETKDEFQQKMVGIDKK-QDLEAKNTQTLTADVKDNEIIEQQ 1022
Query: 1068 QQITDVMKENQKLKKMNAKLI 1088
++I +++E +L++M +I
Sbjct: 1023 RKIFSLIQEKNELQQMLESVI 1043
Score = 48.8 bits (111), Expect = 1e-04
Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 7/183 (3%)
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKD 971
DE + V + + +E+E N + E + + L+ + E+ +
Sbjct: 467 DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK 526
Query: 972 KEFEAKRKELEDCKAELEELKQRYKELDE-ECETCAEYLKQREEQCKRLKEAKIALEIVD 1030
+E E K KE D E E L+++ K+ E E + E L+++E+Q K+L+E +
Sbjct: 527 EEMELKLKEKNDLD-EFEALERKTKKDQENELSSKVELLREKEDQIKKLQEYIDS----Q 581
Query: 1031 KLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITI 1090
KL N K+ L +ES+ + T++ A A+ ++ + EN +LK+ +L T
Sbjct: 582 KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATT 641
Query: 1091 CKK 1093
K+
Sbjct: 642 YKQ 644
Score = 48.0 bits (109), Expect = 2e-04
Identities = 56/288 (19%), Positives = 134/288 (46%), Gaps = 23/288 (7%)
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
++++ + E + L+ L ++++ +L YK+++++ + L+ + + L+KE
Sbjct: 612 TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ 671
Query: 881 SLEQQVSNLKEQIRTQQP------VERQAKFADVA----VNTDEDWANLHSVVV--DRMS 928
S +++ L I + P +E + K D+ +E+ A V++ + S
Sbjct: 672 SAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKS 731
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+EVE RL K I++ K ++L ++ K + K+ + +E+ K +L
Sbjct: 732 LPSEVE---RLRKEIQD---KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 785
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKE--AKIALEIVDKLSNQKVALEKQIESL 1046
+ YK D+E + E++ K + E ++ EIV+ LS + + + +L
Sbjct: 786 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN-LSKEAQKFDSSLGAL 844
Query: 1047 SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKR 1094
T +S T + + VQ +++ ++ + ++L+ ++ L T+ +++
Sbjct: 845 -KTELSYKTQELQEKTREVQ-ERLNEMEQLKEQLENRDSTLQTVEREK 890
>AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb
protein.
Length = 1939
Score = 99.5 bits (237), Expect = 6e-20
Identities = 192/1044 (18%), Positives = 436/1044 (41%), Gaps = 72/1044 (6%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 886 QEKNDLQLQVQAEADALADAE------ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE 939
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSL----KTKSKKINE 142
L K + L E +D+ L + +E E + ++KNLT+ + +T +K E
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 143 ---LQE-ENDTLSNLIME-----NVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVN-- 190
LQE TL +L ME +T++ L ++VDDL+ + E + C+DLE+
Sbjct: 1000 KKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKL 1059
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
E + K+ ++ K+ L + L + +S L I D ++ EL
Sbjct: 1060 EGDLKLAQESTMDTENDKQQLNEKLK-KKEFEMSNLQGKIEDEQALAM--QLQKKIKELQ 1116
Query: 251 AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
A E+ +E E + + E +++ +L+E + E E A E+ + +
Sbjct: 1117 ARIEELEEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQIELNKKREAEF 1175
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQIDLDEI 366
+++ + + + H D AE G SL + ++ ++ +++++++
Sbjct: 1176 QKMRRDLEESTLQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDL 1235
Query: 367 LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDI 426
V +++ ++L+ + ++ E++ N L QK R+H S + +
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQL 1295
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ + ++ + +++ ++ R L+++ A + + +L R YE E
Sbjct: 1296 DEKDAMVSQLSRGKQAFTQQIE-ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE 1354
Query: 487 KE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVDEN 543
+E K L+ G +KA EE K L + L + + V+
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 544 NANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLN 602
A+L K L E++ L I + ++ ++L +K ++++ K++ ++
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE---WKQKYEETQAEL 1471
Query: 603 DVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ +E + ++EL + +++ L+ +K + + K +
Sbjct: 1472 EASQKESRSLSTELFKVKNAYEESLDHLETLKRE---NKNLQQEISDLTEQIAEGGKHIH 1528
Query: 663 EQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
E K+ EK S L+ +++ E + E + I+R+Q ++ +++ E + K+
Sbjct: 1529 ELEKVKKQLDHEK----SELQTSLEEAEASLEHEEGKILRIQLEL---NQVKSEIDRKIA 1581
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
E + + LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1582 EKDEELDQLKRNHLRVVESMQSTLDA--EIRSRNDALRIK-KKMEGDLNEME---IQLNH 1635
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
D L + + D K ++++ + + ++ + +
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMV-ERRANLMQAEVEELRA 1694
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
L+ + K + E +E +Q Q L K LE +S ++ ++ + V+
Sbjct: 1695 SLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM--EDIVQEA 1752
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQDLKNTVTKMQ 961
+ A D A + + A +E+ K+ M +T+++L+ + + + Q
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLGEAE------Q 1806
Query: 962 KAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK 1020
A++ K+ ++ EA+ +ELE + ++E + + K L + E Q EE K +
Sbjct: 1807 LALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNIL 1866
Query: 1021 EAKIALEIVDKLSNQKVALEKQIE 1044
+ ++VDKL + A ++Q E
Sbjct: 1867 RLQ---DLVDKLQTKVKAYKRQAE 1887
Score = 99.1 bits (236), Expect = 8e-20
Identities = 186/1042 (17%), Positives = 425/1042 (40%), Gaps = 63/1042 (6%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE 86
L A+ + D +I+T K+Q I + + +E + E+ K KL E ++K+
Sbjct: 902 LADAEERCDQLIKT-----KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 956
Query: 87 QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT----KSKKINE 142
LE + E + +++K+L E D+ I LT K + +++
Sbjct: 957 DIDDLELTLAKVEKEKHATE---NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN--KIGPKN 200
LQ E D ++ L L ++VDDL+ + E + C+DLE+ + E K+ ++
Sbjct: 1014 LQMEEDKVNTLTKAKT----KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES 1069
Query: 201 ICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELC 260
K+ L + L + +S L I D ++ EL A E+ +E
Sbjct: 1070 TMDTENDKQQLNEKLK-KKEFEMSNLQGKIEDEQALAM--QLQKKIKELQARIEELEEEI 1126
Query: 261 EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKK 320
E + + E +++ +L+E + E E A E+ + + +++ + +
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQIELNKKREAEFQKMRRDLEES 1185
Query: 321 SKDHIDRYKDSLLAVLD--AEFGTT--SLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ H D AE G SL + ++ ++ +++++++ V
Sbjct: 1186 TLQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKA 1245
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEI 436
+++ ++L+ + ++ E++ N L QK R+H S + + +K+ + ++
Sbjct: 1246 KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 437 LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE-KLRLETG 495
+ +++ ++ R L+++ A + + +L R YE E+E K L+ G
Sbjct: 1306 SRGKQAFTQQIE-ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVDENNANLNLIKI- 552
+KA EE K L + L + + V+ A+L K
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR 1424
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQ 612
L E++ L I + ++ ++L +K ++++ K++ ++ + +E +
Sbjct: 1425 LQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE---WKQKYEETQAELEASQKESRSL 1481
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
++EL + +++ L+ +K + + K + E K+
Sbjct: 1482 STELFKVKNAYEESLDHLETLKRE---NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK 732
EK S L+ +++ E + E + I+R+Q ++ + E + K+ E + + LK
Sbjct: 1539 HEK----SELQTSLEEAEASLEHEEGKILRIQLELNQVKS---EIDRKIAEKDEELDQLK 1591
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
R++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1592 RNHLRVVESMQSTLDA--EIRSRNDALRIK-KKMEGDLNEME---IQLNHANRQAAEALR 1645
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYK 852
D L + + D K ++++ + + ++ + + L+ + K
Sbjct: 1646 NLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMV-ERRANLMQAEVEELRASLERTERGRK 1704
Query: 853 ELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNT 912
+ E +E +Q Q L K LE +S ++ ++ R A+ + A
Sbjct: 1705 MAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE--EKAKKA 1762
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEELRYKKQD-----LKNTVTKMQKAMEK 966
D A + + A +E+ K+ M+ T+++L+ + + LK ++QK +
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLGEAEQLALKGGKKQIQKLEAR 1822
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL----KEA 1022
+ + E E+++K + L + ++R KEL + E + + + ++ +L K
Sbjct: 1823 VRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY 1882
Query: 1023 KIALEIVDKLSNQKVALEKQIE 1044
K E ++ SN +A ++++
Sbjct: 1883 KRQAEEAEEQSNVNLAKFRKLQ 1904
Score = 83.4 bits (197), Expect = 4e-15
Identities = 104/547 (19%), Positives = 222/547 (40%), Gaps = 31/547 (5%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
A+ E++M ++ E+ K E ++ ++E L+ + +EK +++ +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKE---LEEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
D++ + + L + L+++C E +D LE+
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
+ EK + L +++ D ET + +LT + +AL+ + + DL+
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLTKEKKALQEAHQQTLDDLQM 1016
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ VN LT K +E ++ +LE + E+ + ++
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEND 1076
Query: 805 NRDLGENPKLDDSPKRSI-SVISDSE--VSQLKERLLSCQQELDDLKERYKELDDECETC 861
+ L E K + ++ I D + QL++++ Q +++L+E E++ E +
Sbjct: 1077 KQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEE---EIEAERASR 1133
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA--NL 919
A+ ++R + L++ LE+ QI + +R+A+F + + +E
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIELNK--KREAEFQKMRRDLEESTLQHEA 1191
Query: 920 HSVVVDRMSYDAEVEKNKR---LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
+ + + D+ E K+ L + ++L +K +LK + + ME +K FE
Sbjct: 1192 TAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEK 1251
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LED +E++ ++ + L E L + R + K A+ V +LS K
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM--VSQLSRGK 1309
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN-QKLKKMNAKLITICKKRG 1095
A +QIE L + A+ + D+++E ++ ++ A+L +RG
Sbjct: 1310 QAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL-----QRG 1364
Query: 1096 KTGANRE 1102
+ AN E
Sbjct: 1365 MSKANSE 1371
Score = 66.5 bits (155), Expect = 5e-10
Identities = 115/596 (19%), Positives = 249/596 (41%), Gaps = 34/596 (5%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 947 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + +L T+ E Q +LE S + K+ +L++ K
Sbjct: 1006 AHQQ------TLDDLQMEEDKVNTLTKAKTK-LEQQVDDLEGSLEQEKKLCMDLERAKRK 1058
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ 696
+ + L++ + K D L + ++ +K E+Q
Sbjct: 1059 LEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQ--KKIKELQ 1116
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSREAVN 750
R I L+++I+ + + E + ++L+ + E + + +A +L REA
Sbjct: 1117 AR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEF 1175
Query: 751 QLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGDENRD 807
Q ++DL E + + +R + +V + E D
Sbjct: 1176 Q-KMRRDLEESTLQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEIND 1234
Query: 808 LGENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
L N + K + + + ++S++K + Q+ +++L + L E +
Sbjct: 1235 LASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQ 1294
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
L E+D ++L + K + QQ+ LK Q+ ++ + ++ A + D L
Sbjct: 1295 LDEKDAMVSQLSRGKQAFTQQIEELKRQL--EEETKAKSTLAHALQSARHDCDLLREQYE 1352
Query: 925 DRMSYDAEVEKN-KRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
+ AE+++ + + + R K + D ++++A +K ++ ++ E + +
Sbjct: 1353 EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVALEK 1041
A LE+ KQR L E E +++ C L K+ + +++ + + +
Sbjct: 1413 SKCASLEKTKQR---LQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQA 1469
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMK-ENQKLKKMNAKLITICKKRGK 1096
++E+ S ST +A ++ + +K EN+ L++ + L + GK
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGK 1525
Score = 58.4 bits (135), Expect = 1e-07
Identities = 164/880 (18%), Positives = 337/880 (38%), Gaps = 72/880 (8%)
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV---MSE 301
+Q+E DA D +E C+ K LE +T +++ N E K K+ SE
Sbjct: 895 VQAEADA-LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 302 IKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
+K++++ L L E +K H K L A T + + + +Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK---HATENKVKNLTEEMAGLDETIAKLTKE-KKALQEAHQQ 1009
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH---EI 418
LD++ + KV N T + +++ L L +++ C L K ++ ++
Sbjct: 1010 TLDDLQMEEDKV----NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQ 475
+ T+D + +L E L K+ ++S L+ I + + KKI L + L +
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEE 1125
Query: 476 YELSRTDY-EIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH---EE 531
E R + EK++ L + + + ++ E + + EE
Sbjct: 1126 IEAERASRAKAEKQRSDLSR-ELEEISERLEEAGGATSAQIELNKKREAEFQKMRRDLEE 1184
Query: 532 LTKLYKSKVDE-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
T +++ + + + L ++ID+L+ K E++ L + N L + T++
Sbjct: 1185 STLQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244
Query: 591 LKEENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
K + ++L D ++ E +T+ E +R + L +
Sbjct: 1245 AKANFEKMCRTLEDQLS-EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVS 1303
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+E+ LK Q EE+T+ S L +++ ++ L++Q +E
Sbjct: 1304 QLSRGKQAFTQQIEE---LKRQLEEETKAKSTLAHALQSARHDCDL-------LREQYEE 1353
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDA-AVKDLESSREAVNQLTTQKDLVEGRIAELES 768
+ + E + +++ ++ + Y+ A++ E EA +L + E + + S
Sbjct: 1354 EQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
+ + + R+ + L + ++ ++
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK--VLAEWKQKYEETQAEL 1471
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
E SQ + R LS EL +K Y+E D ET LK+E +L+Q++S+
Sbjct: 1472 EASQKESRSLST--ELFKVKNAYEESLDHLET--------------LKRENKNLQQEISD 1515
Query: 889 LKEQ-------IRTQQPVERQA--KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-R 938
L EQ I + V++Q + +++ + +E A+L + E+ + K
Sbjct: 1516 LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSE 1575
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ + I E + LK ++ ++M+ + D E ++ L K +L + +L
Sbjct: 1576 IDRKIAEKDEELDQLKRNHLRVVESMQ--STLDAEIRSRNDALRIKKKMEGDLNEMEIQL 1633
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIV----DKLSNQKVALEKQIESL-SNTPVSN 1053
+ AE L+ LK+ ++ L+ D L Q +E++ + +
Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELR 1693
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+++ + Q++ D + Q L N LI KK
Sbjct: 1694 ASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKK 1733
Score = 58.0 bits (134), Expect = 2e-07
Identities = 59/283 (20%), Positives = 130/283 (45%), Gaps = 27/283 (9%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--------------AEYLQER 868
S ++ E++ +KE ++EL + + KEL+++ T A+ L +
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADA 905
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K+ LE ++ + E R + E A+ +++ + L + D
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
A+VEK K + K ++L + + + + K TK+ K EA ++ L+D + E
Sbjct: 964 TLAKVEKEKHATEN------KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017
Query: 988 LEELKQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+++ K +L+++ + L+Q ++ C L+ AK LE KL+ + + +
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077
Query: 1045 SLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
N + ++ ++++Q M+ +K+K++ A++
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQAL-AMQLQKKIKELQARI 1119
Score = 44.0 bits (99), Expect = 0.003
Identities = 28/97 (28%), Positives = 51/97 (52%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ EK ++ + EAKRKELE+ ++ L Q +L + + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEE---KMVTLMQEKNDLQLQVQAEADA 901
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C +L + KI LE K ++ E++I +
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA 938
Score = 35.9 bits (79), Expect = 0.80
Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K + +KE ++E E K EL + + + KEL+E+ T + + Q + +
Sbjct: 841 KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 1022 AKI-ALEIVDKLSNQKVALEKQIESLS 1047
A A E D+L K+ LE +I+ ++
Sbjct: 901 ALADAEERCDQLIKTKIQLEAKIKEVT 927
>AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein.
Length = 1956
Score = 99.5 bits (237), Expect = 6e-20
Identities = 215/1074 (20%), Positives = 439/1074 (40%), Gaps = 108/1074 (10%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK 85
Q+ + KND I++ Q+ + T+ + C+ L +S ++ ++++LS + + +
Sbjct: 899 QVSLTQEKNDLILQLQA------EQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEE 952
Query: 86 EQKSALEGKYQNLI-----LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
E S L + + L L+ + DL +KS E E T + ++KNLT+ ++ ++ I
Sbjct: 953 EINSELTARGRKLEDECFELKKEIDDLETMLVKS-EKEKRTTEHKVKNLTEEVEFLNEDI 1011
Query: 141 NELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE-KLVNESENKIGPK 199
++L + + + + +++ L K N L Q+ +LE L E + ++ +
Sbjct: 1012 SKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCE 1071
Query: 200 --------NICAQCKLKENLIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKICTLQS--- 247
N+ + ENL S H+ + +L S +S + LQ
Sbjct: 1072 RELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVK 1131
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDL---DEKLGE-----------NNEFET 293
EL +D KE E + + +E ++T DL +E+L E + ET
Sbjct: 1132 ELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQET 1191
Query: 294 KAVKVMSEI---------------KRNLNSLSE---QLINNESKKSKDHIDRYKDSLLAV 335
K K+ ++ KR+ +SL+E Q+ N + K K D+ D L V
Sbjct: 1192 KIQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDK-SDLQLEV 1250
Query: 336 LDAEFGTTSLDVFEILMDNIINKYQIDLDEI---LEKYTKVQGDL--------NECTSEL 384
D + + + + Y+ L E L+K T++ DL +E L
Sbjct: 1251 DDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFL 1310
Query: 385 KSVNEKLASLNSQLIEKEN---ACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+ + EK A +N EK N LR Q E+ + SA+ + K + + ++L ++
Sbjct: 1311 RRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDC-DLLREQY 1369
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVX 501
+ ++K ++ R L + + + ++ + Q D + E E A V
Sbjct: 1370 EEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVA 1429
Query: 502 XXXXXXXXXXXXXFDT-LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDAL 560
L +A +++ + +L + ++ A + K EE AL
Sbjct: 1430 NARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADW-KQKHEESQAL 1488
Query: 561 KIAIAKNEEKMLS-LSEKDNKLTELVSTINGLKEENNSLKSLNDVIT---REKETQASEL 616
A K + + + L + N E + L+ EN +L+ +T RE +E+
Sbjct: 1489 LDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEM 1548
Query: 617 ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT 676
E+ ++I++ E+ + EAK+ LE+ L+ K++ E
Sbjct: 1549 EKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENF 1608
Query: 677 RDCSRLEINIKTHEKTAEIQNRM-IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
R + I+ +E ++R+ + RL+K+++ED LNE+ + R
Sbjct: 1609 RRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEED----------LNEMELQLSCANRQV 1658
Query: 736 DAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXX 795
A K L + + L Q D +L SD++ EQ A
Sbjct: 1659 SEATKSLGQLQIQIKDLQMQLD----DSTQLNSDLK-EQVAVAERRNSLLQSELEDLRSL 1713
Query: 796 XXXXTFG---DENRDLGENPKLDDSPKRSISVIS-----DSEVSQLKERLLSCQQELDDL 847
G E L +++ ++ S++S +++V+++++ QE +
Sbjct: 1714 QEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNA 1773
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+E+ K+ E +E L+++ + A L++ + ++EQ +++L++++ + +
Sbjct: 1774 EEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQ 1833
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
+ + L + + AE ++ +RL + I+EL Y+ ++ K +++MQ M+K
Sbjct: 1834 IQ-KLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDK 1892
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK 1020
K + + ++++E + + + +YK+ E E + E Q +LK
Sbjct: 1893 LQLKVQNY---KQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLK 1943
Score = 79.0 bits (186), Expect = 9e-14
Identities = 214/1101 (19%), Positives = 423/1101 (38%), Gaps = 120/1101 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
LKE ++ LEK + ++K ++ +L + +LIL+ Q ++ ++ + E L K
Sbjct: 874 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEE-QCEWLIK 932
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDL----------K 172
K L +K S+++ E +E N L+ + E L KE+DDL K
Sbjct: 933 SK--IQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEK 990
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYD--NTLSKLN--- 227
+ E + + + +NE +K+ Q + + + LH+ + ++LSK N
Sbjct: 991 RTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQ-EAHQQTLDDLHMEEEKLSSLSKANLKL 1049
Query: 228 -RSISDSNTSTRYNKICTLQSE-----LDAGREDCKELCEDFTSIKNHL--ELHEPNMTM 279
+ + + + + + E L+ + +E E+ S + HL EL + + +
Sbjct: 1050 EQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELEL 1109
Query: 280 -DLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAV 335
++ K+ + K + E++ + L E+L +K ++ D +D LA
Sbjct: 1110 SQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQD--LAD 1167
Query: 336 LD---AEFGTTSLDVFEIL--MDNIINKYQIDLDEILEKYTKVQGDLN----ECTSELKS 386
L+ E G +SL EI + I K D++E + L + +EL+
Sbjct: 1168 LNERLEEVGGSSLAQLEITKKQETKIQKLHRDMEEATLHFETTSASLKKRHADSLAELEG 1227
Query: 387 VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSK 446
E L + Q +EK+ + +Q E ++ + K E L +E L +
Sbjct: 1228 QVENLQQV-KQKLEKDKS----DLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEAT 1282
Query: 447 LKIDIPRDLDQDLPAHKKITILF-------------DALITQYELSRTDYEIEKEKLR-- 491
K+D L DL A K T L+ +ALI Q ++++ + E LR
Sbjct: 1283 AKLDKVTQLANDLAAQK--TKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQ 1340
Query: 492 --LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL----------YKSK 539
ET + A+ + EE LH L+K+ Y++
Sbjct: 1341 LEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENN 1400
Query: 540 V-----DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
V D +A L L E +A+ +A A+N + + +L + +S + ++
Sbjct: 1401 VIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSA 1460
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
L + + E S ++ + E+ + ++L
Sbjct: 1461 AARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETL 1520
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
E K+L E+ L Q E T+ N+ EK ++ +Q ++E +
Sbjct: 1521 RRENKNLQEEISNLTNQVREGTK-------NLTEMEKVKKLIEEEKTEVQVTLEETEGAL 1573
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E+K+ L + E L+ + K E E N Q+ ++ + L+S+ ++
Sbjct: 1574 ERNESKI--LHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRI 1631
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE--------NPKLDDSPKRSISVIS 826
T + + LG+ +LDDS + + +
Sbjct: 1632 EVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKE 1691
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
V++ + LL Q EL+DL+ ++ + E L E E+ + SL Q
Sbjct: 1692 QVAVAERRNSLL--QSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQK 1749
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + Q ++A+ E+ A ++ +S E+ K+ TI L
Sbjct: 1750 KKLEADVARMQ---KEAEEVVQECQNAEEKAKKAAIEAANLS-----EELKKKQDTIAHL 1801
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
+++++ T+T +QK + EA++ L + ++++L+ R +EL+ E E
Sbjct: 1802 ERTRENMEQTITDLQKRLA---------EAEQMALMGSRKQIQKLESRVRELEGELEGEI 1852
Query: 1007 EYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLSNTPVSNSTMYVATGSAIV 1065
+ + +RL+ L + + ++ ++ Q++ L V N V
Sbjct: 1853 RRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKL-QLKVQNYKQQVEVAET-Q 1910
Query: 1066 QNQQITDVMKENQKLKKMNAK 1086
NQ ++ K+ +L ++ +
Sbjct: 1911 ANQYLSKYKKQQHELNEVKER 1931
Score = 40.3 bits (90), Expect = 0.037
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 11/111 (9%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K K L+K+ E+ + LK ++QKA+EK EF+ R+EL KA+ L Q
Sbjct: 857 KIKPLVKS-SEVGEEVAGLKEECAQLQKALEK-----SEFQ--REEL---KAKQVSLTQE 905
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
+L + + E L EEQC+ L ++KI LE K +++V E++I S
Sbjct: 906 KNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINS 956
>D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heavy
chain protein.
Length = 1052
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 399/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 75 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 133
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 134 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 179
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 180 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 235
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 236 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 294
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 295 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 341
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 342 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 400
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 401 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 460
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 461 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 520
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 521 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 580
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 581 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 637
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 638 GKNVHELEKSKRALETQMEEMKTQLEELEDELQASE-DAKLRLEVNMQALKGQFERD--- 693
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R K +EG + +LE
Sbjct: 694 -LQARDEQNE--EKRRQLQRQLHEYETELEDERNERALAAAAKKKLEGDLKDLE------ 744
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 745 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 799
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 800 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 859
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 860 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 919
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 920 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 979
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 980 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1031
Score = 93.1 bits (221), Expect = 5e-18
Identities = 201/1016 (19%), Positives = 407/1016 (40%), Gaps = 73/1016 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 49 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 105
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 106 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 163
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 164 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 223
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 224 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 272
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 273 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 331
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 332 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 391
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 392 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 451
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 452 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 511
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 512 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 571
Query: 586 STINGLKEENNSLKSLNDVITREKETQA--------------SELERSCQVIKQNGFELD 631
+ + + + + REKET+A ELER+ +++K +L
Sbjct: 572 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 631
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
K D+ +E K+ LE+ L+++ + RLE+N++ +
Sbjct: 632 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEE---LEDELQASEDAKLRLEVNMQALKG 688
Query: 692 TAE--IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE---ALKRDYDAAVKDLESSR 746
E +Q R +K+ Q +L E ET+L + N+ A K+ + +KDLE
Sbjct: 689 QFERDLQARDEQNEEKRRQLQRQLH-EYETELEDERNERALAAAAKKKLEGDLKDLEL-- 745
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
+A + + +++ ++ ++ +L++ ++ Q + +
Sbjct: 746 QADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 804
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
L E+ + ++ +D E +L E L S + L++ + L+ E L+
Sbjct: 805 QLQEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 860
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV- 923
E + QQ L ++ T++ ++ + A + E + LH +
Sbjct: 861 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 920
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELE 982
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 921 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 980
Query: 983 DCKAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 981 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1036
Score = 71.7 bits (168), Expect = 1e-11
Identities = 156/800 (19%), Positives = 329/800 (41%), Gaps = 66/800 (8%)
Query: 279 MDLDEKLGENNEFETKAV--KVMSEIKRNLNSLSEQLI-----NNE-SKKSKDHIDRYKD 330
+DL+E+L E K KV +E K + L ++++ NN+ SK+ K +R D
Sbjct: 67 LDLEEQLEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEERISD 124
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLD------EILEKYT-KVQGDLNECTSE 383
+ + E +L + +++I++ ++ L + LEK K++GD ++ +
Sbjct: 125 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 184
Query: 384 LKSVNEKLASLNSQLIEKENACN--ILRIQKERIHEISSAVTI-DIVKKENELKEILTKE 440
+ + ++A L QL +KE + R+ E + ++ I ++ ++L+E L E
Sbjct: 185 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 244
Query: 441 CLKLSKLKIDIPRDLDQDLPAHK-KITILFDALITQYEL-SRTDYEIEKEKLRLETGTAK 498
+K + RDL ++L A K ++ D+ TQ EL ++ + E+ K L+ T +
Sbjct: 245 RAARNKAEKQ-KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-R 302
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL-NLIKILSE-- 555
+ + L E + K L K K +++ NA+L +++L +
Sbjct: 303 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 361
Query: 556 -EIDALKIAI-AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
E++ K + A+ +E S+ + EL ++ L+ E S+ + E E +A
Sbjct: 362 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LNEAEGKA 417
Query: 614 SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCE 673
+L + + + ++ + + + L++ + K+ E
Sbjct: 418 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 477
Query: 674 EKTRDCSRLEINIKTHEK-------TAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
R S L I + +K T E R QK+I+ + + EK ++L
Sbjct: 478 ---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 534
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXX 786
L+++ D V DL++ R+ V+ L ++ + +AE E +I ++
Sbjct: 535 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 593
Query: 787 XXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDD 846
R L E + + +R+ ++ +E+ L + + +
Sbjct: 594 EKETKALSLA---------RALEEALEAKEELERTNKMLK-AEMEDLVSSKDDVGKNVHE 643
Query: 847 LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
L++ + L+ + E L+E +++ + KL LE + LK Q ER +
Sbjct: 644 LEKSKRALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQF------ERDLQAR 697
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
D +E+ + + E E+N+R + + + + DLK+ + A++
Sbjct: 698 D---EQNEEKRRQLQRQLHEYETELEDERNERALAAAAKKKLEG-DLKDLELQADSAIKG 753
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL 1026
+ K+ + +++D + ELE+ + E+ + + K E +L+E A
Sbjct: 754 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 813
Query: 1027 EIVDKLSN-QKVALEKQIES 1045
E K ++ +K L +++ S
Sbjct: 814 ERARKQADLEKEELAEELAS 833
Score = 70.1 bits (164), Expect = 4e-11
Identities = 198/1054 (18%), Positives = 429/1054 (40%), Gaps = 90/1054 (8%)
Query: 96 QNLILET-QTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLI 154
+NL+ E Q L ++ + + + K +E++ + ++ + L+EE D L
Sbjct: 3 ENLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR------LEEEEDRGQQLQ 56
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
E + + ++++ + E QK + LEK+ E++ K I L +
Sbjct: 57 AERKKMAQQM-LDLEEQLEEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 114
Query: 215 LHIGYDNTLSKLNRSISDS-----NTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNH 269
+ + +S L ++++ N + NK ++ SEL+ + ++ ++ +K
Sbjct: 115 RKL-LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 173
Query: 270 LELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLI--NNESKKSKDHIDR 327
LE + + + + E + + K E++ L L +++ NN KK ++ ++
Sbjct: 174 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE-LEG 232
Query: 328 YKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY-TKVQGDLNECTS--EL 384
+ L LD+E N K + DL E LE T+++ L+ + EL
Sbjct: 233 HISDLQEDLDSERAAR----------NKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 282
Query: 385 KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI-DIVKKENELKEILTKECLK 443
++ E+ ++ + +++E + ++Q+ R + + + +++ K L K
Sbjct: 283 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 342
Query: 444 LSKLKIDIPRDLDQDLPAHKKITILFDALITQY-ELSRTDYEIEKEKLRLETGTAKAVXX 502
L K D+ +L A +++ L Q EL + E+ + L K
Sbjct: 343 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 402
Query: 503 XXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDA 559
++ A +V SL +L + +E LN+ ++ L EE ++
Sbjct: 403 VESVTGMLNEAEGKAIKLA-KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 461
Query: 560 LK------IAIAKNEEKMLS-----LSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
L+ + +N E+ +S LS+ KL + ST+ L+E + + +T++
Sbjct: 462 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 521
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
E +A+ ++ + + ELD + D+ ++ + +Q LA
Sbjct: 522 YEEKAAAYDKLEKTKNRLQQELDDLVVDL--------DNQRQLVSNLEKKQRKFDQLLAE 573
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
++ K D R + EK + + + L++ ++ ++L E+ K+ L +
Sbjct: 574 EKNISSKYAD-ERDRAEAEAREKETKALS-LARALEEALEAKEEL--ERTNKM--LKAEM 627
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E L D K++ ++ L TQ + ++ ++ ELE +++ + A +
Sbjct: 628 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALK 687
Query: 789 XXXXXXXXXXXTFGDENR-----DLGE-NPKLDDSP-KRSISVISDSEVS-QLKERLLSC 840
+E R L E +L+D +R+++ + ++ LK+ L
Sbjct: 688 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERNERALAAAAKKKLEGDLKDLELQA 747
Query: 841 QQELDDLKERYKELDDECETCAEYLQE-------RDEQCARLK---KEKLSLEQQVSNLK 890
+ +E K+L ++ +E RDE A K K+ SLE + L+
Sbjct: 748 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 807
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYK 949
E + ER K AD+ +E L S + R + E + R+ + EEL +
Sbjct: 808 EDLAA---AERARKQADL--EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 862
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
+ +++ +++KA ++ + E +R + ++ ++L+++ KEL + +
Sbjct: 863 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 922
Query: 1010 KQREEQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQN 1067
K + + EAKIA E V++ + +K A K ++ + + + V + +
Sbjct: 923 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQVEDERKMAE- 980
Query: 1068 QQITDVMKENQKLKKMNAKLITICKKRGKTGANR 1101
Q K N ++K++ +L ++ + ANR
Sbjct: 981 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1014
Score = 66.9 bits (156), Expect = 4e-10
Identities = 163/946 (17%), Positives = 365/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 143 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 201
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 202 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 259
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 260 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 318
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 319 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 378
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 379 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 434
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 435 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 479
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 480 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 539
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 540 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 591
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 592 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 650
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 651 LETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 710
Query: 612 QASELERSCQVIKQN----GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + + K++ D+ + + L Q
Sbjct: 711 QLHEYETELEDERNERALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 770
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 771 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 828
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 829 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 876
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 877 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 936
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 937 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 996
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 997 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1041
Score = 54.4 bits (125), Expect = 2e-06
Identities = 100/553 (18%), Positives = 220/553 (39%), Gaps = 42/553 (7%)
Query: 523 NEVKSLHEEL---TKLYKSKVDENNANLNLIKILSEEI-DALKIAIAKNEEKMLSLSEKD 578
N L E+L T+LY ++ +E L K EEI ++ + + E++ L +
Sbjct: 1 NSENLLQEQLQAETELY-AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 59
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
K+ + + + EE + + + E + +LE V+ +L K +
Sbjct: 60 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK--- 116
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ ++AK+L + LK + E S LE+ +K EK+ + +
Sbjct: 117 LLEERISDLTTNLAEEEEKAKNLTK----LKNKHESMI---SELEVRLKKEEKSRQELEK 169
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ +L+ + + + + ++ EL + + + AA+ L+ N +
Sbjct: 170 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 229
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
+EG I++L+ D+ +E+ A D +L
Sbjct: 230 LEGHISDLQEDLDSERAA---RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 286
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE 878
++ ++V+ + L E S + ++ ++++++ + +E E L++ A L K
Sbjct: 287 EQEVTVLKKA----LDEETRSHEAQVQEMRQKHAQAVEE---LTEQLEQFKRAKANLDKN 339
Query: 879 KLSLEQQVSNLKEQIR----TQQPVERQAKFADVAV----NTDEDWANLHSVVVDRM-SY 929
K +LE++ ++L ++R +Q VE + K + V + D + + D++
Sbjct: 340 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 399
Query: 930 DAEVEKNKRLMKTIE----ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
EVE ++ E +L L + + Q+ +++ T++ K ++LE+ +
Sbjct: 400 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 459
Query: 986 AELEELKQRYKELDEECETCAEYLK-QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
L++ E + E L Q + K+L++ V+ L K +K+IE
Sbjct: 460 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIE 516
Query: 1045 SLSNTPVSNSTMY 1057
+L+ + Y
Sbjct: 517 NLTQQYEEKAAAY 529
>BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 400/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 1019
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 1020 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 1065
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 1066 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 1121
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 1180
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 1181 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 1227
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 1228 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 1523
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-DAKLRLEVNMQALKGQFERD--- 1579
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R+ K +EG + +LE
Sbjct: 1580 -LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE------ 1630
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 1631 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 1685
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 92.3 bits (219), Expect = 9e-18
Identities = 203/1014 (20%), Positives = 406/1014 (40%), Gaps = 69/1014 (6%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 991
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 1049
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 1110 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 1158
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 1159 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK----MKADILMXX 641
+ + + + + REKET+A L R+ + + EL++ +KA++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE------KTRDCS-RLEINIKTHEKTAE 694
++L Q +K Q EE T D RLE+N++ + E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 695 --IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL----KRDYDAAVKDLESSREA 748
+Q R +K+ Q +L E ET+L + K AL K+ + +KDLE +A
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLH-EYETELED-ERKQRALAAAAKKKLEGDLKDLEL--QA 1633
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +++ ++ ++ +L++ ++ Q + + L
Sbjct: 1634 DSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E+ + ++ +D E +L E L S + L++ + L+ E L+E
Sbjct: 1693 QEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV-VD 925
+ QQ L ++ T++ ++ + A + E + LH +
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDC 984
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 985 KAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 77.4 bits (182), Expect = 3e-13
Identities = 206/1085 (18%), Positives = 445/1085 (41%), Gaps = 92/1085 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q+ ++ K L + + +++K LE ++ +E L + L+ +++
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 141 NELQE-------ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
E +E + L ++ E + L+ + + Q+ +DLE+ + E E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 194 ---NKIGPKNICAQCKLKENLIQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
K+ + + A+ K+K+ + L + +N LSK + + + R + + T +E
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE-----RISDLTTNLAEE 1018
Query: 250 DAGREDCKELCEDFTSIKNHLELH---EPNMTMDLDE---KL-GENNEFETKAVKV---M 299
+ ++ +L S+ + LE+ E +L++ KL G+ ++F + + +
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV---FEILMDNII 356
+E+K L E+L + D I + ++L + + E + L E N
Sbjct: 1079 AELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 357 NKYQIDLDEILEKY-TKVQGDLNECTS--ELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K + DL E LE T+++ L+ + EL++ E+ ++ + +++E + ++Q+
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 414 RIHEISSAVTI-DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
R + + + +++ K L K L K D+ +L A +++ L
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 473 ITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q EL + E+ + L K ++ A +V SL +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-KDVASLSSQ 1316
Query: 532 LTKLYKSKVDENNANLNL---IKILSEEIDALK------IAIAKNEEKMLS-----LSEK 577
L + +E LN+ ++ L EE ++L+ + +N E+ +S LS+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
KL + ST+ L+E + + +T++ E +A+ ++ + + ELD + D+
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
++ + +Q LA ++ K D R + EK + +
Sbjct: 1437 --------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALS 1487
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ +
Sbjct: 1488 -LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE-N 811
++ ++ ELE +++ + A + +E R L E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 812 PKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-- 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 868 -----RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
RDE A K K+ SLE + L+E + ER K AD+ +E L
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAEEL 1717
Query: 920 HSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + R + E + R+ + EEL ++ +++ +++KA ++ + E +R
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQK 1036
+ ++ ++L+++ KEL + +K + + EAKIA E V++ + +K
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
A K ++ + + + V + + Q K N ++K++ +L ++ +
Sbjct: 1838 QAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 1097 TGANR 1101
ANR
Sbjct: 1896 INANR 1900
Score = 77.0 bits (181), Expect = 4e-13
Identities = 167/856 (19%), Positives = 350/856 (40%), Gaps = 73/856 (8%)
Query: 263 FTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
FT +K L++ M E +L + E + KA + E+++ + L+E+ N ++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQL 896
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + Y + AE L + ++ I+++ + L+E ++ ++Q
Sbjct: 897 QAETELYAE-------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ------- 942
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+E K + +++ L QL E+E A L+++K + +I+ +++ + L+KE
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK-LSKER 1001
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQYEL-----SRTDYEIEKEKLRLE 493
L + D+ +L ++ K +T L +++I++ E+ ++ E+EK K +LE
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---- 549
G A L + E+++ L +L +NNA +
Sbjct: 1062 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNNALKKIRELE 1117
Query: 550 --IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENN 596
I L E++D+ + A K E++ L E+ L TEL T++ ++E
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 597 SLKSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
LK D TR E Q E+ ++ Q +++ +L++ K
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-- 1295
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 1296 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLK 834
+ +D + L++ KR I + ++Q
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQY 1408
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
E + +L+ K R L E + L + + + L+K++ +Q ++ K I
Sbjct: 1409 EEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-IS 1464
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDL 953
++ ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 1465 SKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETC 1005
V +++K+ + +E + + +EL ED K LE Q K + + + +
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 1006 AEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSA 1063
E +++ Q +R L E + LE K A +K++E L + + + A
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 1064 IVQNQQITDVMKENQK 1079
I Q +++ MK+ Q+
Sbjct: 1644 IKQLRKLQAQMKDFQR 1659
Score = 68.5 bits (160), Expect = 1e-10
Identities = 165/946 (17%), Positives = 366/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 1145
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 1146 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 1320
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 1321 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 1365
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 1426 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 1536
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 612 QASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + KQ K++ D+ + + L Q
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 1714
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 1715 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1927
Score = 47.6 bits (108), Expect = 2e-04
Identities = 44/196 (22%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
CA YL+ R+ Q RL + L Q +E + +++ + A N ++ H
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 921 SVVVDRMSY-DAEVEKNKRLMKTIEELRY----KKQDLKNTVTKMQKAMEKYTKKDKEFE 975
S + + + +++ L EE+R KKQ+L+ + +M+ +E+ + ++ +
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 976 AKRKELE----DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+RK++ D + +LEE + ++L E T +K+ E++ + + +K
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN------NK 996
Query: 1032 LSNQKVALEKQIESLS 1047
LS ++ LE++I L+
Sbjct: 997 LSKERKLLEERISDLT 1012
>BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 400/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 1019
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 1020 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 1065
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 1066 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 1121
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 1180
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 1181 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 1227
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 1228 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 1523
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-DAKLRLEVNMQALKGQFERD--- 1579
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R+ K +EG + +LE
Sbjct: 1580 -LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE------ 1630
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 1631 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 1685
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 92.3 bits (219), Expect = 9e-18
Identities = 203/1014 (20%), Positives = 406/1014 (40%), Gaps = 69/1014 (6%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 935 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 991
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 1049
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 1110 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 1158
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 1159 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK----MKADILMXX 641
+ + + + + REKET+A L R+ + + EL++ +KA++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE------KTRDCS-RLEINIKTHEKTAE 694
++L Q +K Q EE T D RLE+N++ + E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 695 --IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL----KRDYDAAVKDLESSREA 748
+Q R +K+ Q +L E ET+L + K AL K+ + +KDLE +A
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLH-EYETELED-ERKQRALAAAAKKKLEGDLKDLEL--QA 1633
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +++ ++ ++ +L++ ++ Q + + L
Sbjct: 1634 DSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E+ + ++ +D E +L E L S + L++ + L+ E L+E
Sbjct: 1693 QEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV-VD 925
+ QQ L ++ T++ ++ + A + E + LH +
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDC 984
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 985 KAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 77.4 bits (182), Expect = 3e-13
Identities = 206/1085 (18%), Positives = 445/1085 (41%), Gaps = 92/1085 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q+ ++ K L + + +++K LE ++ +E L + L+ +++
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 141 NELQE-------ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
E +E + L ++ E + L+ + + Q+ +DLE+ + E E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 194 ---NKIGPKNICAQCKLKENLIQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
K+ + + A+ K+K+ + L + +N LSK + + + R + + T +E
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE-----RISDLTTNLAEE 1018
Query: 250 DAGREDCKELCEDFTSIKNHLELH---EPNMTMDLDE---KL-GENNEFETKAVKV---M 299
+ ++ +L S+ + LE+ E +L++ KL G+ ++F + + +
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV---FEILMDNII 356
+E+K L E+L + D I + ++L + + E + L E N
Sbjct: 1079 AELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 357 NKYQIDLDEILEKY-TKVQGDLNECTS--ELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K + DL E LE T+++ L+ + EL++ E+ ++ + +++E + ++Q+
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 414 RIHEISSAVTI-DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
R + + + +++ K L K L K D+ +L A +++ L
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 473 ITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q EL + E+ + L K ++ A +V SL +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-KDVASLSSQ 1316
Query: 532 LTKLYKSKVDENNANLNL---IKILSEEIDALK------IAIAKNEEKMLS-----LSEK 577
L + +E LN+ ++ L EE ++L+ + +N E+ +S LS+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
KL + ST+ L+E + + +T++ E +A+ ++ + + ELD + D+
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
++ + +Q LA ++ K D R + EK + +
Sbjct: 1437 --------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALS 1487
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ +
Sbjct: 1488 -LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE-N 811
++ ++ ELE +++ + A + +E R L E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 812 PKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-- 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 868 -----RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
RDE A K K+ SLE + L+E + ER K AD+ +E L
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAEEL 1717
Query: 920 HSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + R + E + R+ + EEL ++ +++ +++KA ++ + E +R
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQK 1036
+ ++ ++L+++ KEL + +K + + EAKIA E V++ + +K
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
A K ++ + + + V + + Q K N ++K++ +L ++ +
Sbjct: 1838 QAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 1097 TGANR 1101
ANR
Sbjct: 1896 INANR 1900
Score = 77.0 bits (181), Expect = 4e-13
Identities = 167/856 (19%), Positives = 350/856 (40%), Gaps = 73/856 (8%)
Query: 263 FTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
FT +K L++ M E +L + E + KA + E+++ + L+E+ N ++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQL 896
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + Y + AE L + ++ I+++ + L+E ++ ++Q
Sbjct: 897 QAETELYAE-------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ------- 942
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+E K + +++ L QL E+E A L+++K + +I+ +++ + L+KE
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK-LSKER 1001
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQYEL-----SRTDYEIEKEKLRLE 493
L + D+ +L ++ K +T L +++I++ E+ ++ E+EK K +LE
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---- 549
G A L + E+++ L +L +NNA +
Sbjct: 1062 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNNALKKIRELE 1117
Query: 550 --IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENN 596
I L E++D+ + A K E++ L E+ L TEL T++ ++E
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 597 SLKSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
LK D TR E Q E+ ++ Q +++ +L++ K
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-- 1295
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 1296 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLK 834
+ +D + L++ KR I + ++Q
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQY 1408
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
E + +L+ K R L E + L + + + L+K++ +Q ++ K I
Sbjct: 1409 EEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-IS 1464
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDL 953
++ ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 1465 SKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETC 1005
V +++K+ + +E + + +EL ED K LE Q K + + + +
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 1006 AEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSA 1063
E +++ Q +R L E + LE K A +K++E L + + + A
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 1064 IVQNQQITDVMKENQK 1079
I Q +++ MK+ Q+
Sbjct: 1644 IKQLRKLQAQMKDFQR 1659
Score = 68.5 bits (160), Expect = 1e-10
Identities = 165/946 (17%), Positives = 366/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 1145
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 1146 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 1320
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 1321 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 1365
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 1426 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 1536
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 612 QASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + KQ K++ D+ + + L Q
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 1714
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 1715 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1927
Score = 47.6 bits (108), Expect = 2e-04
Identities = 44/196 (22%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
CA YL+ R+ Q RL + L Q +E + +++ + A N ++ H
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 921 SVVVDRMSY-DAEVEKNKRLMKTIEELRY----KKQDLKNTVTKMQKAMEKYTKKDKEFE 975
S + + + +++ L EE+R KKQ+L+ + +M+ +E+ + ++ +
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 976 AKRKELE----DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+RK++ D + +LEE + ++L E T +K+ E++ + + +K
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN------NK 996
Query: 1032 LSNQKVALEKQIESLS 1047
LS ++ LE++I L+
Sbjct: 997 LSKERKLLEERISDLT 1012
>AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin heavy
chain isoform SM2 protein.
Length = 1945
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 400/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 1026
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 1027 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 1072
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 1073 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 1128
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 1187
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 1188 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 1234
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 1235 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 1530
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-DAKLRLEVNMQALKGQFERD--- 1586
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R+ K +EG + +LE
Sbjct: 1587 -LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE------ 1637
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 1638 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 1692
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 92.3 bits (219), Expect = 9e-18
Identities = 203/1014 (20%), Positives = 406/1014 (40%), Gaps = 69/1014 (6%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 998
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 1056
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 1117 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 1165
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 1166 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK----MKADILMXX 641
+ + + + + REKET+A L R+ + + EL++ +KA++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE------KTRDCS-RLEINIKTHEKTAE 694
++L Q +K Q EE T D RLE+N++ + E
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 695 --IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL----KRDYDAAVKDLESSREA 748
+Q R +K+ Q +L E ET+L + K AL K+ + +KDLE +A
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLH-EYETELED-ERKQRALAAAAKKKLEGDLKDLEL--QA 1640
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +++ ++ ++ +L++ ++ Q + + L
Sbjct: 1641 DSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E+ + ++ +D E +L E L S + L++ + L+ E L+E
Sbjct: 1700 QEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV-VD 925
+ QQ L ++ T++ ++ + A + E + LH +
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDC 984
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 985 KAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 77.4 bits (182), Expect = 3e-13
Identities = 206/1085 (18%), Positives = 445/1085 (41%), Gaps = 92/1085 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q+ ++ K L + + +++K LE ++ +E L + L+ +++
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 141 NELQE-------ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
E +E + L ++ E + L+ + + Q+ +DLE+ + E E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 194 ---NKIGPKNICAQCKLKENLIQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
K+ + + A+ K+K+ + L + +N LSK + + + R + + T +E
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE-----RISDLTTNLAEE 1025
Query: 250 DAGREDCKELCEDFTSIKNHLELH---EPNMTMDLDE---KL-GENNEFETKAVKV---M 299
+ ++ +L S+ + LE+ E +L++ KL G+ ++F + + +
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV---FEILMDNII 356
+E+K L E+L + D I + ++L + + E + L E N
Sbjct: 1086 AELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 357 NKYQIDLDEILEKY-TKVQGDLNECTS--ELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K + DL E LE T+++ L+ + EL++ E+ ++ + +++E + ++Q+
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 414 RIHEISSAVTI-DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
R + + + +++ K L K L K D+ +L A +++ L
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 473 ITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q EL + E+ + L K ++ A +V SL +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-KDVASLSSQ 1323
Query: 532 LTKLYKSKVDENNANLNL---IKILSEEIDALK------IAIAKNEEKMLS-----LSEK 577
L + +E LN+ ++ L EE ++L+ + +N E+ +S LS+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
KL + ST+ L+E + + +T++ E +A+ ++ + + ELD + D+
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
++ + +Q LA ++ K D R + EK + +
Sbjct: 1444 --------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALS 1494
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ +
Sbjct: 1495 -LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE-N 811
++ ++ ELE +++ + A + +E R L E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 812 PKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-- 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 868 -----RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
RDE A K K+ SLE + L+E + ER K AD+ +E L
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAEEL 1724
Query: 920 HSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + R + E + R+ + EEL ++ +++ +++KA ++ + E +R
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQK 1036
+ ++ ++L+++ KEL + +K + + EAKIA E V++ + +K
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
A K ++ + + + V + + Q K N ++K++ +L ++ +
Sbjct: 1845 QAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 1097 TGANR 1101
ANR
Sbjct: 1903 INANR 1907
Score = 77.0 bits (181), Expect = 4e-13
Identities = 167/856 (19%), Positives = 350/856 (40%), Gaps = 73/856 (8%)
Query: 263 FTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
FT +K L++ M E +L + E + KA + E+++ + L+E+ N ++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQL 903
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + Y + AE L + ++ I+++ + L+E ++ ++Q
Sbjct: 904 QAETELYAE-------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ------- 949
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+E K + +++ L QL E+E A L+++K + +I+ +++ + L+KE
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK-LSKER 1008
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQYEL-----SRTDYEIEKEKLRLE 493
L + D+ +L ++ K +T L +++I++ E+ ++ E+EK K +LE
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---- 549
G A L + E+++ L +L +NNA +
Sbjct: 1069 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNNALKKIRELE 1124
Query: 550 --IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENN 596
I L E++D+ + A K E++ L E+ L TEL T++ ++E
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 597 SLKSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
LK D TR E Q E+ ++ Q +++ +L++ K
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-- 1302
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 1303 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLK 834
+ +D + L++ KR I + ++Q
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQY 1415
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
E + +L+ K R L E + L + + + L+K++ +Q ++ K I
Sbjct: 1416 EEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-IS 1471
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDL 953
++ ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 1472 SKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETC 1005
V +++K+ + +E + + +EL ED K LE Q K + + + +
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 1006 AEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSA 1063
E +++ Q +R L E + LE K A +K++E L + + + A
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 1064 IVQNQQITDVMKENQK 1079
I Q +++ MK+ Q+
Sbjct: 1651 IKQLRKLQAQMKDFQR 1666
Score = 68.5 bits (160), Expect = 1e-10
Identities = 165/946 (17%), Positives = 366/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 1152
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 1153 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 1327
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 1328 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 1372
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 1433 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 1543
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 612 QASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + KQ K++ D+ + + L Q
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 1721
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 1722 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1934
Score = 47.6 bits (108), Expect = 2e-04
Identities = 44/196 (22%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
CA YL+ R+ Q RL + L Q +E + +++ + A N ++ H
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 921 SVVVDRMSY-DAEVEKNKRLMKTIEELRY----KKQDLKNTVTKMQKAMEKYTKKDKEFE 975
S + + + +++ L EE+R KKQ+L+ + +M+ +E+ + ++ +
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 976 AKRKELE----DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+RK++ D + +LEE + ++L E T +K+ E++ + + +K
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN------NK 1003
Query: 1032 LSNQKVALEKQIESLS 1047
LS ++ LE++I L+
Sbjct: 1004 LSKERKLLEERISDLT 1019
>AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin heavy
chain isoform SM1 protein.
Length = 1979
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 400/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 1026
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 1027 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 1072
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 1073 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 1128
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 1187
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 1188 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 1234
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 1235 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 1530
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-DAKLRLEVNMQALKGQFERD--- 1586
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R+ K +EG + +LE
Sbjct: 1587 -LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE------ 1637
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 1638 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 1692
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 92.3 bits (219), Expect = 9e-18
Identities = 203/1014 (20%), Positives = 406/1014 (40%), Gaps = 69/1014 (6%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 942 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 998
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 1056
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 1117 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 1165
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 1166 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK----MKADILMXX 641
+ + + + + REKET+A L R+ + + EL++ +KA++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE------KTRDCS-RLEINIKTHEKTAE 694
++L Q +K Q EE T D RLE+N++ + E
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 695 --IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL----KRDYDAAVKDLESSREA 748
+Q R +K+ Q +L E ET+L + K AL K+ + +KDLE +A
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLH-EYETELED-ERKQRALAAAAKKKLEGDLKDLEL--QA 1640
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +++ ++ ++ +L++ ++ Q + + L
Sbjct: 1641 DSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E+ + ++ +D E +L E L S + L++ + L+ E L+E
Sbjct: 1700 QEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV-VD 925
+ QQ L ++ T++ ++ + A + E + LH +
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDC 984
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 985 KAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 77.4 bits (182), Expect = 3e-13
Identities = 206/1085 (18%), Positives = 445/1085 (41%), Gaps = 92/1085 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q+ ++ K L + + +++K LE ++ +E L + L+ +++
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 141 NELQE-------ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
E +E + L ++ E + L+ + + Q+ +DLE+ + E E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 194 ---NKIGPKNICAQCKLKENLIQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
K+ + + A+ K+K+ + L + +N LSK + + + R + + T +E
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE-----RISDLTTNLAEE 1025
Query: 250 DAGREDCKELCEDFTSIKNHLELH---EPNMTMDLDE---KL-GENNEFETKAVKV---M 299
+ ++ +L S+ + LE+ E +L++ KL G+ ++F + + +
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV---FEILMDNII 356
+E+K L E+L + D I + ++L + + E + L E N
Sbjct: 1086 AELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 357 NKYQIDLDEILEKY-TKVQGDLNECTS--ELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K + DL E LE T+++ L+ + EL++ E+ ++ + +++E + ++Q+
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 414 RIHEISSAVTI-DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
R + + + +++ K L K L K D+ +L A +++ L
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 473 ITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q EL + E+ + L K ++ A +V SL +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-KDVASLSSQ 1323
Query: 532 LTKLYKSKVDENNANLNL---IKILSEEIDALK------IAIAKNEEKMLS-----LSEK 577
L + +E LN+ ++ L EE ++L+ + +N E+ +S LS+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
KL + ST+ L+E + + +T++ E +A+ ++ + + ELD + D+
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
++ + +Q LA ++ K D R + EK + +
Sbjct: 1444 --------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALS 1494
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ +
Sbjct: 1495 -LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE-N 811
++ ++ ELE +++ + A + +E R L E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 812 PKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-- 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 868 -----RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
RDE A K K+ SLE + L+E + ER K AD+ +E L
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAEEL 1724
Query: 920 HSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + R + E + R+ + EEL ++ +++ +++KA ++ + E +R
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQK 1036
+ ++ ++L+++ KEL + +K + + EAKIA E V++ + +K
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
A K ++ + + + V + + Q K N ++K++ +L ++ +
Sbjct: 1845 QAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 1097 TGANR 1101
ANR
Sbjct: 1903 INANR 1907
Score = 77.0 bits (181), Expect = 4e-13
Identities = 167/856 (19%), Positives = 350/856 (40%), Gaps = 73/856 (8%)
Query: 263 FTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
FT +K L++ M E +L + E + KA + E+++ + L+E+ N ++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQL 903
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + Y + AE L + ++ I+++ + L+E ++ ++Q
Sbjct: 904 QAETELYAE-------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ------- 949
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+E K + +++ L QL E+E A L+++K + +I+ +++ + L+KE
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK-LSKER 1008
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQYEL-----SRTDYEIEKEKLRLE 493
L + D+ +L ++ K +T L +++I++ E+ ++ E+EK K +LE
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---- 549
G A L + E+++ L +L +NNA +
Sbjct: 1069 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNNALKKIRELE 1124
Query: 550 --IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENN 596
I L E++D+ + A K E++ L E+ L TEL T++ ++E
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 597 SLKSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
LK D TR E Q E+ ++ Q +++ +L++ K
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-- 1302
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 1303 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLK 834
+ +D + L++ KR I + ++Q
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQY 1415
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
E + +L+ K R L E + L + + + L+K++ +Q ++ K I
Sbjct: 1416 EEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-IS 1471
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDL 953
++ ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 1472 SKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETC 1005
V +++K+ + +E + + +EL ED K LE Q K + + + +
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Query: 1006 AEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSA 1063
E +++ Q +R L E + LE K A +K++E L + + + A
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 1064 IVQNQQITDVMKENQK 1079
I Q +++ MK+ Q+
Sbjct: 1651 IKQLRKLQAQMKDFQR 1666
Score = 68.5 bits (160), Expect = 1e-10
Identities = 165/946 (17%), Positives = 366/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 1152
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 1153 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 1327
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 1328 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 1372
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 1433 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 1543
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 612 QASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + KQ K++ D+ + + L Q
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 1721
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 1722 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1934
Score = 47.6 bits (108), Expect = 2e-04
Identities = 44/196 (22%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
CA YL+ R+ Q RL + L Q +E + +++ + A N ++ H
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 921 SVVVDRMSY-DAEVEKNKRLMKTIEELRY----KKQDLKNTVTKMQKAMEKYTKKDKEFE 975
S + + + +++ L EE+R KKQ+L+ + +M+ +E+ + ++ +
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 976 AKRKELE----DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+RK++ D + +LEE + ++L E T +K+ E++ + + +K
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN------NK 1003
Query: 1032 LSNQKVALEKQIESLS 1047
LS ++ LE++I L+
Sbjct: 1004 LSKERKLLEERISDLT 1019
>AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain protein.
Length = 1938
Score = 99.1 bits (236), Expect = 8e-20
Identities = 199/1060 (18%), Positives = 428/1060 (40%), Gaps = 80/1060 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ QS L D+ + C+ L +S + K+++L+ L + +E S
Sbjct: 886 QEKNDLQLQVQSETENLMDAE------ERCEGLIKSKILLEAKVKELTERLEEEEEMNSE 939
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K +NL + + RD+ L + +E E + ++KNL++ + + I++L +E
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI------GPKN 200
+L + + + +V+ L K N L Q+ DLE + E E K+ +
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL-EQEKKLRADLERAKRK 1058
Query: 201 ICAQCKLKENLIQSLHIGYDNTLSKLNRS---ISDSNTSTRYNKICTLQ-----SELDAG 252
+ K+ + I L KL + +S ++ +LQ EL A
Sbjct: 1059 LEGDLKMSQESIMDLENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQAR 1118
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ +E E +++ +E ++ +L+E + E E + A E+ + + ++
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQRSDLARELEE-ISERLEEASGATSAQIEMNKKREAEFQK 1177
Query: 313 LINNESKKSKDHIDRYKDSLLAVLD--AEFGTT--SLDVFEILMDNIINKYQIDLDEILE 368
+ + + + H D AE G +L + ++ ++ ++++D++
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
+ + ++V ++ + + ++ ++ + L +QK R+ + ++ + +
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
KE+ + + LTK L++ ++ R ++++ A + + +L R YE E+E
Sbjct: 1298 KESLISQ-LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 489 -KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL 547
K L+ +KA EE K L + L + + N+
Sbjct: 1357 AKAELQRALSKANSEVAQWKTKYETDAIQRTEELEEAKKKLAQRLQEAEEKTETANSKCA 1416
Query: 548 NLIKI---LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
+L K L E++ L + ++ +L +K ++++ K++ + ++ +
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE---WKQKLDESQAELEA 1473
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+E + ++EL + ++ +L+ ++ + + K+L E
Sbjct: 1474 AQKESRSLSTELFKMRNAYEEVVDQLETLRRE---NKNLQEEISDLTEQIAETGKNLQEA 1530
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
K +EK S L++ ++ E + E + I+R+Q ++ + E + K+ E
Sbjct: 1531 EKTKKLVEQEK----SDLQVALEEVEGSLEHEESKILRVQLELSQVKS---ELDRKVIEK 1583
Query: 725 TNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+ E LKR+ A + L+S +A N K +EG + E+E +
Sbjct: 1584 DEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAET 1643
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL------K 834
N DL E + + +R+ ++ + E ++ +
Sbjct: 1644 QRHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVE--RRNGLLLEELEEMKVALEQTER 1701
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
R LS +QEL D +R + L + + ++ + A+ + E + Q+ N +E+ +
Sbjct: 1702 TRRLS-EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760
Query: 895 -----TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN--KRLMKTIEELR 947
E K D + + + NL V D E E+ K K I++L
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL-----EDCKAEL------EELKQRYK 996
+ ++L+N + QK + K ++E K KE+ ED K L ++L+ + K
Sbjct: 1821 NRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVK 1880
Query: 997 ELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQ 1035
+ E E + +C+R++ E + A E D +Q
Sbjct: 1881 SYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQ 1920
Score = 78.2 bits (184), Expect = 2e-13
Identities = 181/961 (18%), Positives = 394/961 (40%), Gaps = 73/961 (7%)
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNL---NKEVDDLKKNNEC 177
TK++ ++ + + K ++ LQE+ND L ++ +E++NL + + L K+
Sbjct: 863 TKEELARSEARRKELEEKMVSLLQEKND----LQLQVQSETENLMDAEERCEGLIKSKIL 918
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L K +L + + E E + A+ + E+ SL D+ L + + + +
Sbjct: 919 LEAKVKELTERLEEEEEM--NSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATE 976
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
NK+ L E+ A E+ +L ++ S++ E H+ T+D D ++ E+ +K
Sbjct: 977 --NKVKNLSEEMTALEENISKLTKEKKSLQ---EAHQ--QTLD-DLQVEEDKV--NGLIK 1026
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD-AEFGTTSLDVFEILMDNII 356
+ +++++ + L L + KK + ++R K L L ++ L+ + ++ +
Sbjct: 1027 INAKLEQQTDDLEGSL--EQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKL 1084
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER-- 414
K + +L ++ + Q + ++K + ++ L + IE E+ +I+K+R
Sbjct: 1085 KKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEE-IEAEHTLRA-KIEKQRSD 1142
Query: 415 ----IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR-DLDQDLPA---HKKIT 466
+ EIS + ++ E+ K + K++ D+ L + A KK
Sbjct: 1143 LARELEEISERLEEASGATSAQI-EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA 1201
Query: 467 ILFDALITQYE-LSRTDYEIEKEK--LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
L Q + L R ++EKEK L++E + T+E+ +
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 524 EVKSLHEELTKLY------KSKVDENNANLNLI----KILSEEIDALKIAIAKNEEKMLS 573
E+K+ E+ T+L K+++ N L+ + L ++ K A+ + E++
Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD-K 632
E++ K ++ + L+ + L + E+E +A EL+R+ + K
Sbjct: 1322 QMEEETKAKNAMA--HALQSSRHDCDLLREQYEEEQEAKA-ELQRALSKANSEVAQWKTK 1378
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
+ D + EA+ E+ +C + RL+ ++ +
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAE---EKTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E + L K+ + DK+ E + KL+E + EA +++ + +L R A ++
Sbjct: 1436 LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 753 TTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q + + L+ +I TEQ A E ++
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE--EVEG 1553
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLK---ERYKE-----LDDECETCA 862
+ + ++S + + S+L +++ +E++ LK +R E LD E +
Sbjct: 1554 SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN 1613
Query: 863 EYLQERDEQCARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKF-ADVAVNTDEDWAN 918
+ L+ + + L + ++ L +Q++ + +RT Q + ++ D A+ ++ED
Sbjct: 1614 DALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALRSNEDLKE 1673
Query: 919 LHSVVVDRMSYDAE-VEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
++V R E +E+ K ++ E R +Q+L + ++Q + T +
Sbjct: 1674 QLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKK 1733
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
++ C+AE+E Q + +E+ + E+ K+ ++ LE + K Q
Sbjct: 1734 LEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793
Query: 1037 V 1037
V
Sbjct: 1794 V 1794
Score = 67.7 bits (158), Expect = 2e-10
Identities = 77/423 (18%), Positives = 172/423 (40%), Gaps = 20/423 (4%)
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
L+ + L+++C RD LE+ + EK + L +++ E
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTA-------LEEN 992
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+++LT + ++L+ + + DL+ + VN L +E + +LE + E+
Sbjct: 993 ISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADL 1052
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSC 840
+E + + E K + + D E + L
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKKKEFELSQLQARIDDE----QVHSLQF 1108
Query: 841 QQELDDLKERYKELDDECET----CAEYLQERDEQCARLKK--EKLSLEQQVSNLKEQIR 894
Q+++ +L+ R +EL++E E A+ ++R + L++ E+L ++ + ++
Sbjct: 1109 QKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMKTIEELRYKKQDL 953
++ E Q D+ T + A ++ + AE+ E+ L + ++L +K +L
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSEL 1228
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE 1013
K + M +E +K E + +ED +E++ ++ +L + L+ +
Sbjct: 1229 KMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQN 1288
Query: 1014 EQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDV 1073
+ E K +L + +L+ K AL +Q+E L + A A+ ++ D+
Sbjct: 1289 GELSHRVEEKESL--ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 1074 MKE 1076
++E
Sbjct: 1347 LRE 1349
Score = 59.3 bits (137), Expect = 8e-08
Identities = 92/467 (19%), Positives = 193/467 (41%), Gaps = 35/467 (7%)
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E+ MK D ++ SLL++ L+ Q + +T + E +
Sbjct: 852 EMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEG 911
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
K+ + + L ++++E++++ E K L +K +LKRD D DLE +
Sbjct: 912 LIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID----DLELT--- 964
Query: 749 VNQLTTQKDLVEGRIAELESDIRT-EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ ++ +K E ++ L ++ E+ + N
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE 867
+ N KL+ D E S +E+ L DL+ ++L+ + + E + +
Sbjct: 1025 IKINAKLEQQ-------TDDLEGSLEQEKKLRA-----DLERAKRKLEGDLKMSQESIMD 1072
Query: 868 RDEQCARLKKEKLSLEQQVSNLKEQIRTQQ--PVERQAKFADVAVNTDEDWANLHSVVVD 925
+ + +++++ E ++S L+ +I +Q ++ Q K ++ +E L +
Sbjct: 1073 LENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEE----LEEEIEA 1128
Query: 926 RMSYDAEVEKNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A++EK + L + +EE+ + ++ T Q M K K++ EF+ R++LE+
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASG-ATSAQIEMNK--KREAEFQKMRRDLEEA 1185
Query: 985 KAELEELKQ--RYKELDEECETCAEYLK-QREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+ E R K+ D E + QR +Q +++++ +EI D SN + AL K
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE-ALSK 1244
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQ-ITDVMKENQKLKKMNAKL 1087
++ T + + + Q Q I D+ + +L+ N +L
Sbjct: 1245 SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291
Score = 55.6 bits (128), Expect = 9e-07
Identities = 60/284 (21%), Positives = 136/284 (47%), Gaps = 29/284 (10%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDD--------------ECETCAEYLQER 868
S ++ E++ +KE ++EL + R KEL++ + ++ E L +
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C L K K+ LE +V L E++ ++ E ++ N ++ ++L + D
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEE--EMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
+VEK K + K ++L +T +++ + K TK+ K EA ++ L+D + E
Sbjct: 964 TLTKVEKEKHATEN------KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 988 LEELKQRYK---ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQI 1043
+++ K +L+++ + L+Q ++ L+ AK LE K+S + + LE +
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEK 1077
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + + ++ A + ++Q+ ++ +K+K++ A++
Sbjct: 1078 QQIEE-KLKKKEFELSQLQARIDDEQVHS-LQFQKKIKELQARI 1119
Score = 41.1 bits (92), Expect = 0.021
Identities = 26/97 (26%), Positives = 52/97 (53%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ E+ ++ EA+RKELE+ ++ L Q +L + ++ E
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEE---KMVSLLQEKNDLQLQVQSETEN 901
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C+ L ++KI LE K +++ E+++ S
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNS 938
>AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY11)
(5'partial) protein.
Length = 1857
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 400/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 846 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 904
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 905 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 950
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 951 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 1006
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 1007 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 1065
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 1066 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 1112
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 1113 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1171
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 1172 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1231
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 1232 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1291
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 1292 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1351
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 1352 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 1408
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 1409 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-DAKLRLEVNMQALKGQFERD--- 1464
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R+ K +EG + +LE
Sbjct: 1465 -LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE------ 1515
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 1516 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 1570
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 1571 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1630
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 1631 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1690
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 1691 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1750
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 1751 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1802
Score = 92.3 bits (219), Expect = 9e-18
Identities = 203/1014 (20%), Positives = 406/1014 (40%), Gaps = 69/1014 (6%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 820 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 876
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 877 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 934
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 935 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 994
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 995 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 1043
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 1044 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1102
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 1103 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1162
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 1163 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1222
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 1223 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1282
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 1283 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1342
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK----MKADILMXX 641
+ + + + + REKET+A L R+ + + EL++ +KA++
Sbjct: 1343 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1402
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE------KTRDCS-RLEINIKTHEKTAE 694
++L Q +K Q EE T D RLE+N++ + E
Sbjct: 1403 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1462
Query: 695 --IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL----KRDYDAAVKDLESSREA 748
+Q R +K+ Q +L E ET+L + K AL K+ + +KDLE +A
Sbjct: 1463 RDLQARDEQNEEKRRQLQRQLH-EYETELED-ERKQRALAAAAKKKLEGDLKDLEL--QA 1518
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +++ ++ ++ +L++ ++ Q + + L
Sbjct: 1519 DSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1577
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E+ + ++ +D E +L E L S + L++ + L+ E L+E
Sbjct: 1578 QEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1633
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV-VD 925
+ QQ L ++ T++ ++ + A + E + LH +
Sbjct: 1634 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1693
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDC 984
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 1694 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1753
Query: 985 KAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 1754 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1807
Score = 77.4 bits (182), Expect = 3e-13
Identities = 206/1085 (18%), Positives = 445/1085 (41%), Gaps = 92/1085 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q+ ++ K L + + +++K LE ++ +E L + L+ +++
Sbjct: 729 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 788
Query: 141 NELQE-------ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
E +E + L ++ E + L+ + + Q+ +DLE+ + E E
Sbjct: 789 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 848
Query: 194 ---NKIGPKNICAQCKLKENLIQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
K+ + + A+ K+K+ + L + +N LSK + + + R + + T +E
Sbjct: 849 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE-----RISDLTTNLAEE 903
Query: 250 DAGREDCKELCEDFTSIKNHLELH---EPNMTMDLDE---KL-GENNEFETKAVKV---M 299
+ ++ +L S+ + LE+ E +L++ KL G+ ++F + + +
Sbjct: 904 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 963
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV---FEILMDNII 356
+E+K L E+L + D I + ++L + + E + L E N
Sbjct: 964 AELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1022
Query: 357 NKYQIDLDEILEKY-TKVQGDLNECTS--ELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K + DL E LE T+++ L+ + EL++ E+ ++ + +++E + ++Q+
Sbjct: 1023 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1082
Query: 414 RIHEISSAVTI-DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
R + + + +++ K L K L K D+ +L A +++ L
Sbjct: 1083 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1142
Query: 473 ITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q EL + E+ + L K ++ A +V SL +
Sbjct: 1143 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-KDVASLSSQ 1201
Query: 532 LTKLYKSKVDENNANLNL---IKILSEEIDALK------IAIAKNEEKMLS-----LSEK 577
L + +E LN+ ++ L EE ++L+ + +N E+ +S LS+
Sbjct: 1202 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1261
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
KL + ST+ L+E + + +T++ E +A+ ++ + + ELD + D+
Sbjct: 1262 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1321
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
++ + +Q LA ++ K D R + EK + +
Sbjct: 1322 --------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALS 1372
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ +
Sbjct: 1373 -LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1427
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE-N 811
++ ++ ELE +++ + A + +E R L E
Sbjct: 1428 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1487
Query: 812 PKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-- 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 1488 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1547
Query: 868 -----RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
RDE A K K+ SLE + L+E + ER K AD+ +E L
Sbjct: 1548 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAEEL 1602
Query: 920 HSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + R + E + R+ + EEL ++ +++ +++KA ++ + E +R
Sbjct: 1603 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1662
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQK 1036
+ ++ ++L+++ KEL + +K + + EAKIA E V++ + +K
Sbjct: 1663 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1722
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
A K ++ + + + V + + Q K N ++K++ +L ++ +
Sbjct: 1723 QAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQR 1780
Query: 1097 TGANR 1101
ANR
Sbjct: 1781 INANR 1785
Score = 77.0 bits (181), Expect = 4e-13
Identities = 167/856 (19%), Positives = 350/856 (40%), Gaps = 73/856 (8%)
Query: 263 FTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
FT +K L++ M E +L + E + KA + E+++ + L+E+ N ++
Sbjct: 723 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQL 781
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + Y + AE L + ++ I+++ + L+E ++ ++Q
Sbjct: 782 QAETELYAE-------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ------- 827
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+E K + +++ L QL E+E A L+++K + +I+ +++ + L+KE
Sbjct: 828 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK-LSKER 886
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQYEL-----SRTDYEIEKEKLRLE 493
L + D+ +L ++ K +T L +++I++ E+ ++ E+EK K +LE
Sbjct: 887 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 946
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---- 549
G A L + E+++ L +L +NNA +
Sbjct: 947 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNNALKKIRELE 1002
Query: 550 --IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENN 596
I L E++D+ + A K E++ L E+ L TEL T++ ++E
Sbjct: 1003 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1062
Query: 597 SLKSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
LK D TR E Q E+ ++ Q +++ +L++ K
Sbjct: 1063 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1122
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 1123 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-- 1180
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 1181 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1235
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLK 834
+ +D + L++ KR I + ++Q
Sbjct: 1236 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQY 1293
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
E + +L+ K R L E + L + + + L+K++ +Q ++ K I
Sbjct: 1294 EEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-IS 1349
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDL 953
++ ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 1350 SKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1408
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETC 1005
V +++K+ + +E + + +EL ED K LE Q K + + + +
Sbjct: 1409 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1468
Query: 1006 AEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSA 1063
E +++ Q +R L E + LE K A +K++E L + + + A
Sbjct: 1469 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1528
Query: 1064 IVQNQQITDVMKENQK 1079
I Q +++ MK+ Q+
Sbjct: 1529 IKQLRKLQAQMKDFQR 1544
Score = 68.5 bits (160), Expect = 1e-10
Identities = 165/946 (17%), Positives = 366/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 914 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 972
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 973 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 1030
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 1031 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1089
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 1090 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1149
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 1150 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 1205
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 1206 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 1250
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 1251 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1310
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 1311 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 1362
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 1363 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 1421
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 1422 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1481
Query: 612 QASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + KQ K++ D+ + + L Q
Sbjct: 1482 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1541
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 1542 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 1599
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 1600 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1647
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 1648 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1707
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 1708 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1767
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 1768 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1812
Score = 47.6 bits (108), Expect = 2e-04
Identities = 44/196 (22%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
CA YL+ R+ Q RL + L Q +E + +++ + A N ++ H
Sbjct: 708 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 767
Query: 921 SVVVDRMSY-DAEVEKNKRLMKTIEELRY----KKQDLKNTVTKMQKAMEKYTKKDKEFE 975
S + + + +++ L EE+R KKQ+L+ + +M+ +E+ + ++ +
Sbjct: 768 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 827
Query: 976 AKRKELE----DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+RK++ D + +LEE + ++L E T +K+ E++ + + +K
Sbjct: 828 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN------NK 881
Query: 1032 LSNQKVALEKQIESLS 1047
LS ++ LE++I L+
Sbjct: 882 LSKERKLLEERISDLT 897
>AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein.
Length = 1984
Score = 99.1 bits (236), Expect = 8e-20
Identities = 197/1012 (19%), Positives = 400/1012 (39%), Gaps = 74/1012 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
+E + L+LEK++ E K + L QN L + R LL +I L ++
Sbjct: 973 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEE 1031
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI 183
++ KNLT +L+ +++++ + + + + + +E++ LK+ L
Sbjct: 1032 EKAKNLT-----------KLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDAS 1077
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
D + + + + +I + Q KE +Q+ D+ +++ N ++ + I
Sbjct: 1078 DFHEQIADLQAQIA--ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH--IS 1133
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
LQ +LD+ R + + + LE + + LD E K + ++ +K
Sbjct: 1134 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLK 1192
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
+ +L E+ ++E++ + R K + E T L+ F+ N+ Q
Sbjct: 1193 K---ALDEETRSHEAQVQE---MRQKHAQA----VEELTEQLEQFKRAKANLDKNKQ--- 1239
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN---ILRIQ-KERIHEIS 419
+ ++ + G+L + V K L +Q+ E ++ C+ R + +++H++
Sbjct: 1240 -TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1298
Query: 420 SAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ V ++ + E E K I L K+ LS D L ++ ++ L +
Sbjct: 1299 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1358
Query: 478 --LSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+ D E+E K+ L T + LEE + E LT+
Sbjct: 1359 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1418
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
Y+ K + L +E+D L + + + + +L +K K +L++ + +
Sbjct: 1419 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1478
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
+ + REKET+A L R+ + + EL++ M
Sbjct: 1479 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDV 1535
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR-LQKQIQEDDKL 713
L + AL+ Q EE LE ++ E A+++ + M+ L+ Q + D
Sbjct: 1536 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-DAKLRLEVNMQALKGQFERD--- 1591
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L+R +LE R+ K +EG + +LE
Sbjct: 1592 -LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE------ 1642
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ D R+L E+ + + + ++ + L
Sbjct: 1643 ----LQADSAIKGREEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSL 1697
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L+ Q++L + K+ D E E AE L L+ EK LE +++ L+E++
Sbjct: 1698 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1757
Query: 894 RTQQ-----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
+Q +R K A + A S S ++E+ NK L + E+
Sbjct: 1758 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1817
Query: 948 -YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
K K+T+ ++ K + + ++E K+ + K + ++LK+ ++++E +
Sbjct: 1818 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1877
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+Y +Q E+ R+K+ K LE ++ S + A ++++ L SN M
Sbjct: 1878 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1929
Score = 92.3 bits (219), Expect = 9e-18
Identities = 203/1014 (20%), Positives = 406/1014 (40%), Gaps = 69/1014 (6%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ ++ + +K++ ++ D++EQ E Q L LE T + ++IK LE E L D
Sbjct: 947 EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE---AKIKKLEDEILVMD 1003
Query: 124 KEIKNLTDSLKTKSKKINELQ----EENDTLSNLI-MENVTESDNLNKEVDDLKKNNECL 178
+ L+ K ++I++L EE + NL ++N ES + E++ K E
Sbjct: 1004 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES--MISELEVRLKKEEKS 1061
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTS 236
Q+ L++ + + + Q ++ E +Q L++L+ I+ N +
Sbjct: 1062 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1121
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
+ KI EL+ D +E + + +N E + DL E+L E + E +
Sbjct: 1122 LK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLGEEL-EALKTELEDT 1170
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ ++ L + EQ + KK+ D R ++ + + + ++ E L
Sbjct: 1171 LDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1229
Query: 357 NKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIEKENACNI---LRIQ 411
K +D + + LEK + G+L + V K L +Q+ E ++ C+ R +
Sbjct: 1230 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1289
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
+++H++ + V ++ + E E K I L K+ LS D L ++ ++
Sbjct: 1290 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1349
Query: 469 FDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + D E+E K+ L T + LEE
Sbjct: 1350 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1409
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ E LT+ Y+ K + L +E+D L + + + + +L +K K +L+
Sbjct: 1410 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1469
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK----MKADILMXX 641
+ + + + + REKET+A L R+ + + EL++ +KA++
Sbjct: 1470 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1529
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE------KTRDCS-RLEINIKTHEKTAE 694
++L Q +K Q EE T D RLE+N++ + E
Sbjct: 1530 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1589
Query: 695 --IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL----KRDYDAAVKDLESSREA 748
+Q R +K+ Q +L E ET+L + K AL K+ + +KDLE +A
Sbjct: 1590 RDLQARDEQNEEKRRQLQRQLH-EYETELED-ERKQRALAAAAKKKLEGDLKDLEL--QA 1645
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ + +++ ++ ++ +L++ ++ Q + + L
Sbjct: 1646 DSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1704
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E+ + ++ +D E +L E L S + L++ + L+ E L+E
Sbjct: 1705 QEDLAAAERARKQ----ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1760
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA--DVAVNTDEDWANLHSVV-VD 925
+ QQ L ++ T++ ++ + A + E + LH +
Sbjct: 1761 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1820
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDC 984
+ + + + + + +EE ++ K TK K +K K+ + E +RK E
Sbjct: 1821 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1880
Query: 985 KAELEE----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
K + E+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 1881 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1934
Score = 77.4 bits (182), Expect = 3e-13
Identities = 206/1085 (18%), Positives = 445/1085 (41%), Gaps = 92/1085 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q+ ++ K L + + +++K LE ++ +E L + L+ +++
Sbjct: 856 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 915
Query: 141 NELQE-------ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
E +E + L ++ E + L+ + + Q+ +DLE+ + E E
Sbjct: 916 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 975
Query: 194 ---NKIGPKNICAQCKLKENLIQSLHIG-YDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
K+ + + A+ K+K+ + L + +N LSK + + + R + + T +E
Sbjct: 976 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE-----RISDLTTNLAEE 1030
Query: 250 DAGREDCKELCEDFTSIKNHLELH---EPNMTMDLDE---KL-GENNEFETKAVKV---M 299
+ ++ +L S+ + LE+ E +L++ KL G+ ++F + + +
Sbjct: 1031 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1090
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV---FEILMDNII 356
+E+K L E+L + D I + ++L + + E + L E N
Sbjct: 1091 AELKMQLAKKEEEL-QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1149
Query: 357 NKYQIDLDEILEKY-TKVQGDLNECTS--ELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K + DL E LE T+++ L+ + EL++ E+ ++ + +++E + ++Q+
Sbjct: 1150 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1209
Query: 414 RIHEISSAVTI-DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
R + + + +++ K L K L K D+ +L A +++ L
Sbjct: 1210 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1269
Query: 473 ITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q EL + E+ + L K ++ A +V SL +
Sbjct: 1270 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA-KDVASLSSQ 1328
Query: 532 LTKLYKSKVDENNANLNL---IKILSEEIDALK------IAIAKNEEKMLS-----LSEK 577
L + +E LN+ ++ L EE ++L+ + +N E+ +S LS+
Sbjct: 1329 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1388
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
KL + ST+ L+E + + +T++ E +A+ ++ + + ELD + D+
Sbjct: 1389 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1448
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
++ + +Q LA ++ K D R + EK + +
Sbjct: 1449 --------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKALS 1499
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ +
Sbjct: 1500 -LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1554
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE-N 811
++ ++ ELE +++ + A + +E R L E
Sbjct: 1555 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1614
Query: 812 PKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-- 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 1615 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1674
Query: 868 -----RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
RDE A K K+ SLE + L+E + ER K AD+ +E L
Sbjct: 1675 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAEEL 1729
Query: 920 HSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + R + E + R+ + EEL ++ +++ +++KA ++ + E +R
Sbjct: 1730 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1789
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQK 1036
+ ++ ++L+++ KEL + +K + + EAKIA E V++ + +K
Sbjct: 1790 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1849
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
A K ++ + + + V + + Q K N ++K++ +L ++ +
Sbjct: 1850 QAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEESQR 1907
Query: 1097 TGANR 1101
ANR
Sbjct: 1908 INANR 1912
Score = 77.0 bits (181), Expect = 4e-13
Identities = 167/856 (19%), Positives = 350/856 (40%), Gaps = 73/856 (8%)
Query: 263 FTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
FT +K L++ M E +L + E + KA + E+++ + L+E+ N ++
Sbjct: 850 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQL 908
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + Y + AE L + ++ I+++ + L+E ++ ++Q
Sbjct: 909 QAETELYAE-------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ------- 954
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
+E K + +++ L QL E+E A L+++K + +I+ +++ + L+KE
Sbjct: 955 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK-LSKER 1013
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITIL---FDALITQYEL-----SRTDYEIEKEKLRLE 493
L + D+ +L ++ K +T L +++I++ E+ ++ E+EK K +LE
Sbjct: 1014 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1073
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---- 549
G A L + E+++ L +L +NNA +
Sbjct: 1074 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNNALKKIRELE 1129
Query: 550 --IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENN 596
I L E++D+ + A K E++ L E+ L TEL T++ ++E
Sbjct: 1130 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1189
Query: 597 SLKSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
LK D TR E Q E+ ++ Q +++ +L++ K
Sbjct: 1190 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1249
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 1250 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-- 1307
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 1308 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1362
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLK 834
+ +D + L++ KR I + ++Q
Sbjct: 1363 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQY 1420
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
E + +L+ K R L E + L + + + L+K++ +Q ++ K I
Sbjct: 1421 EEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-IS 1476
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDL 953
++ ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 1477 SKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1535
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETC 1005
V +++K+ + +E + + +EL ED K LE Q K + + + +
Sbjct: 1536 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1595
Query: 1006 AEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSA 1063
E +++ Q +R L E + LE K A +K++E L + + + A
Sbjct: 1596 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1655
Query: 1064 IVQNQQITDVMKENQK 1079
I Q +++ MK+ Q+
Sbjct: 1656 IKQLRKLQAQMKDFQR 1671
Score = 68.5 bits (160), Expect = 1e-10
Identities = 165/946 (17%), Positives = 366/946 (38%), Gaps = 74/946 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K+K++++I +K ++ + K+ + L+ +++ + ++ L ++ ++K Q +
Sbjct: 1041 KNKHESMISELEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1099
Query: 91 LEGKYQNLIL----ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQ 144
E + Q + E ++ + +I+ LE + +L +D + + + K K+ +L
Sbjct: 1100 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLG 1157
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICA 203
EE + L + E+ +S +E+ ++ + +K +D E +E++ ++ K+ A
Sbjct: 1158 EELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1216
Query: 204 QCKLKENLIQ--SLHIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDC 256
+L E L Q D L + +D R ++ + +L+A ++
Sbjct: 1217 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1276
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+ C D + L + +++ G NE E KA+K+ ++ SLS QL +
Sbjct: 1277 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDT 1332
Query: 317 ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGD 376
+ ++ R K ++ +T L E N Q LDE +E ++
Sbjct: 1333 QELLQEE--TRQKLNV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERH 1377
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENEL 433
++ +L +KL S + E + + E + +E +A + K +N L
Sbjct: 1378 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1437
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
++ L + L D R L +L ++ FD L+ + + + Y E+++ E
Sbjct: 1438 QQELDDLVVDL-----DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAE 1489
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-I 552
+ + LE + +K+ E+L K V +N L K
Sbjct: 1490 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRA 1548
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKET 611
L +++ +K + + E+++ + + +L + + G E + + N+ R+ +
Sbjct: 1549 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1608
Query: 612 QASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
Q E E + KQ K++ D+ + + L Q
Sbjct: 1609 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1668
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ + E+ + K +EK A+ +M+LQ+ + ++ + + + EL
Sbjct: 1669 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-- 1726
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXX 784
++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 1727 ------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1774
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQE 843
+ +N + + + RS + + + S+ K + + + +
Sbjct: 1775 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1834
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ L+E+ ++ E + + L+++D++ + + + KEQ +Q
Sbjct: 1835 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1894
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + N + + R D E N+ + + + L+ K
Sbjct: 1895 KRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 1939
Score = 47.6 bits (108), Expect = 2e-04
Identities = 44/196 (22%), Positives = 93/196 (47%), Gaps = 15/196 (7%)
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
CA YL+ R+ Q RL + L Q +E + +++ + A N ++ H
Sbjct: 835 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 894
Query: 921 SVVVDRMSY-DAEVEKNKRLMKTIEELRY----KKQDLKNTVTKMQKAMEKYTKKDKEFE 975
S + + + +++ L EE+R KKQ+L+ + +M+ +E+ + ++ +
Sbjct: 895 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 954
Query: 976 AKRKELE----DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+RK++ D + +LEE + ++L E T +K+ E++ + + +K
Sbjct: 955 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN------NK 1008
Query: 1032 LSNQKVALEKQIESLS 1047
LS ++ LE++I L+
Sbjct: 1009 LSKERKLLEERISDLT 1024
>X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain (1437
AA) protein.
Length = 1437
Score = 94.7 bits (225), Expect = 2e-18
Identities = 204/1093 (18%), Positives = 447/1093 (40%), Gaps = 87/1093 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K KND ++ QS L D+ + C+ L ++ ++ K+++++ + +E +
Sbjct: 384 KEKNDLQLQVQSEADSLADAE------ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE 437
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 438 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKE 497
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ A+ K
Sbjct: 498 KKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL-EQEKKLRMDLERAKRK 556
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSI 266
L+ +L + DN K D + +I L S+++ + +L + +
Sbjct: 557 LEGDLKLAQESTMDNENDKQQ---LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKEL 613
Query: 267 KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN-NESKKSKDHI 325
+ +E +L E++ KA K S++ R L +SE+L + ++ +
Sbjct: 614 QARIE--------ELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEL 665
Query: 326 DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY---QIDLDEILEKYTKVQGDLNECTS 382
++ +++ L + +L E ++ + K+ +L E ++ +V+ L + S
Sbjct: 666 NKKREAEFQKLRRDLEEATLQ-HEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKS 724
Query: 383 ELKSVNEKLASLNSQLIEK-------------ENACNILRIQKERIHEISSAVTIDIVKK 429
ELK + L+S N++ I K E+ + L+ ++E + + +T +
Sbjct: 725 ELKMETDDLSS-NAEAISKAKGNLEKDGGRSLEDQVSELKTKEEEQQRLINDLTAQRARL 783
Query: 430 ENEL----KEILTKECL--KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDY 483
+ E +++ K+ L +LS+ K + +++ ++ T +AL + SR D
Sbjct: 784 QTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDC 843
Query: 484 EIEKEKLRLE-TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
++ +E+ E G A+ +T +A + L EE K ++ E
Sbjct: 844 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTNTETDAIQRTEEL-EEAKKKLAQRLQE 902
Query: 543 NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLN 602
++ + ++ K + E ++ E+ N + K++ N K L+
Sbjct: 903 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD-----KKQRNFDKVLS 957
Query: 603 DVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ + +ETQA ELE S + + EL K+K E L
Sbjct: 958 EWKQKYEETQA-ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLT 1016
Query: 663 EQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNR--MIMRLQKQIQEDDKLFI 715
EQ +Q E K + + EI E A +++ I+R+Q ++ +++
Sbjct: 1017 EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLEL---NQVKS 1073
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E + K+ E + + LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ +
Sbjct: 1074 EVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA--EIRSRNDALRVK-KKMEGDLNEME- 1129
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ + L + + + K ++++ + + L+
Sbjct: 1130 --IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIV-ERRANLLQA 1186
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
+ L+ + K + E +E +Q Q L K LE VS L+ ++
Sbjct: 1187 EIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV-- 1244
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLK 954
++ ++ + A D A + + A +E+ K L +T+++L+++ + +
Sbjct: 1245 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1304
Query: 955 NTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQRE 1013
Q A++ K+ ++ EA+ +ELE + + E + + K L + E Q E
Sbjct: 1305 ------QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTE 1358
Query: 1014 EQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDV 1073
E K + + ++VDKL + + ++Q E +N + + + + ++ D+
Sbjct: 1359 EDRKNVLRLQ---DLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADI 1415
Query: 1074 MKENQKLKKMNAK 1086
+ ++ K+ K
Sbjct: 1416 AE--SQVNKLRVK 1426
Score = 77.8 bits (183), Expect = 2e-13
Identities = 109/530 (20%), Positives = 218/530 (41%), Gaps = 38/530 (7%)
Query: 555 EEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
+E+ +K K ++++ K +L E + T+ LKE+N+ L + E ++ A
Sbjct: 349 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTL--LKEKND----LQLQVQSEADSLAD 402
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
ER Q+IK N +L+ ++ + L + L+++C E
Sbjct: 403 AEERCEQLIK-NKIQLEAKIKEV----------TERAEEEEEINAELTAKKRKLEDECSE 451
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
+D LE+ + EK + L +++ D ET + +L+ + +AL+
Sbjct: 452 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLSKEKKALQET 504
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ + DL++ + VN LT K +E ++ +LE + EQ +
Sbjct: 505 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL--EQEKKLRMDLERAKRKLEGDLK 562
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
T +EN + KL+ ++IS E Q E + Q+++ +L+ R +EL
Sbjct: 563 LAQESTMDNENDKQQLDEKLEKKEFEISNLISKIEDEQAVE--IQLQKKIKELQARIEEL 620
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKFADVAVNT 912
+E E + ++Q + L +E + +++ Q + +R+A+F + +
Sbjct: 621 GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL 680
Query: 913 DEDWANLHSVVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
+E ++V A+ E+ L + ++L +K +LK + E
Sbjct: 681 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 740
Query: 968 TKKDKEFEAK-RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL 1026
+K E + LED +EL+ ++ + L + L+ + R + K AL
Sbjct: 741 SKAKGNLEKDGGRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDAL 800
Query: 1027 EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
V +LS K A +QIE L + + A A+ ++ D+++E
Sbjct: 801 --VSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE 848
Score = 67.3 bits (157), Expect = 3e-10
Identities = 115/596 (19%), Positives = 245/596 (41%), Gaps = 33/596 (5%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 445 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE 503
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + L T+ E Q +LE S + K+ +L++ K
Sbjct: 504 THQQ------TLDDLQAEEDKVNILTKAKTK-LEQQVDDLEGSLEQEKKLRMDLERAKRK 556
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ 696
+ + LE+ K D +EI ++ +K E+Q
Sbjct: 557 LEGDLKLAQESTMDNENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ--KKIKELQ 614
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSREAVN 750
R I L ++I+ + + E + ++L+ + E + + +A +L REA
Sbjct: 615 AR-IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEF 673
Query: 751 QLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGDENRD 807
Q ++DL E + + + +R + ++ + E D
Sbjct: 674 Q-KLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD 732
Query: 808 LGENPKLDDSPKRSISVIS----DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L N + K ++ + +VS+LK + Q+ ++DL + L E +
Sbjct: 733 LSSNAEAISKAKGNLEKDGGRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR 792
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
L E+D ++L + K + QQ+ LK Q+ ++ + + A ++ D L
Sbjct: 793 QLDEKDALVSQLSRSKQASTQQIEELKHQL--EEETKAKNALAHALQSSRHDCDLLREQY 850
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKK-DKEFEAKRKELE 982
+ AE++ + L K E+ + + + + + +E+ KK + + + +E
Sbjct: 851 EEEQEGKAELQ--RALSKANSEVAQWRTNTETDAIQRTEELEEAKKKLAQRLQEAEEHVE 908
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVALEK 1041
A+ L++ + L E E +++ C L K+ + +++ + + +
Sbjct: 909 AVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQA 968
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
++E+ S ST + ++ Q+ + +EN+ L++ + L + GK
Sbjct: 969 ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1024
Score = 62.5 bits (145), Expect = 8e-09
Identities = 202/1087 (18%), Positives = 406/1087 (37%), Gaps = 100/1087 (9%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDL-LMSQIKSLE 116
K ++ KE + + + +K EL + ++ LE K L+ E L + S+ SL
Sbjct: 343 KSAETEKEMAT-MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA 401
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
++ IKN L+ K K++ E EE + ++ E + L E +LKK+ +
Sbjct: 402 DAEERCEQLIKNKIQ-LEAKIKEVTERAEEEEEIN---AELTAKKRKLEDECSELKKDID 457
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
L +EK + +ENK+ +NL + + G D T++KL++ +
Sbjct: 458 DLELTLAKVEKEKHATENKV------------KNLTEEM-AGLDETIAKLSKE-KKALQE 503
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
T + LQ+E ED + T K LE DL+ L + +
Sbjct: 504 THQQTLDDLQAE-----EDKVNI---LTKAKTKLE----QQVDDLEGSLEQEKKLRMDLE 551
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ +++ +L E ++NE+ K + LD + ++ L+ I
Sbjct: 552 RAKRKLEGDLKLAQESTMDNENDKQQ-------------LDEKLEKKEFEISN-LISKIE 597
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
++ +++ ++ +K ++Q + E E+++ A Q + + L ER+
Sbjct: 598 DEQAVEI-QLQKKIKELQARIEELGEEIEAERASRAKAEKQ---RSDLSRELEEISERLE 653
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA-HKKITILFDALITQ 475
E A + + EL + E KL + + + + A KK L Q
Sbjct: 654 EAGGATSAQV-----ELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ 708
Query: 476 YE-LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD---TLEEAHNEVKSLHEE 531
+ L R ++EKEK L+ T D +LE+ +E+K+ EE
Sbjct: 709 IDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKDGGRSLEDQVSELKTKEEE 768
Query: 532 LTKLYKSKVDEN---NANLNLIKILSEEIDALKIAIAKNEEKMLS-LSEKDNKLTELVST 587
+L + +E DAL ++++++ + E ++L E
Sbjct: 769 QQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKA 828
Query: 588 INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
N L S + D++ + E E E ++ + L K +++
Sbjct: 829 KNALAHALQSSRHDCDLLREQYE---EEQEGKAELQRA----LSKANSEVAQWRTNTETD 881
Query: 648 XXXXXXXXDEAKSLLEQNL--------ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+EAK L Q L A+ +C + RL+ ++ E N
Sbjct: 882 AIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA 941
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
L K+ + DK+ E + K E + EA +++ + +L + + Q + +
Sbjct: 942 CAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL 1001
Query: 760 EGRIAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
L+ +I TEQ A E + + + ++
Sbjct: 1002 RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA--SLEHEEG 1059
Query: 818 PKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE--------LDDECETCAEYLQERD 869
I + + S++ ++ +E+D LK + LD E + + L+ +
Sbjct: 1060 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKK 1119
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIR----TQQPVERQAKFADVAVNTDEDWANLHSVVVD 925
+ L + ++ L E +R TQ ++ D A+ ED ++V
Sbjct: 1120 KMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVER 1179
Query: 926 RMSY-DAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELED 983
R + AE+E+ ++ E R +Q+L + ++Q + T + ++
Sbjct: 1180 RANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ 1239
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQ 1042
++E+EE+ Q + +E+ + E+ K+ ++ LE + K Q V L+ +
Sbjct: 1240 LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1299
Query: 1043 IESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
++ + + A V +++ ++ QK K + ++R K +
Sbjct: 1300 LDEAEQLALKGGKKQIQKLEARV--RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQT 1357
Query: 1103 NEDPSDV 1109
ED +V
Sbjct: 1358 EEDRKNV 1364
Score = 56.8 bits (131), Expect = 4e-07
Identities = 185/986 (18%), Positives = 381/986 (38%), Gaps = 80/986 (8%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
+IK L S +T+ + +E T L + K V LK+ N+ Q +
Sbjct: 337 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 396
Query: 185 LEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICT 244
+ L + E C Q +K + I ++ I+ T+ +
Sbjct: 397 ADSLADAEER-------CEQL-IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRK---- 444
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEP-NMTMDLDEKLGENNEFETKAVKVMSEIK 303
L+ E ++D +L + T K E H N +L E++ +E K K ++
Sbjct: 445 LEDECSELKKDIDDL--ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ 502
Query: 304 RNLNSLSEQLINNESK-----KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ L E K K+K +++ D L L+ E + ++ K
Sbjct: 503 ETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE------KKLRMDLERAKRK 556
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ DL E + D + +L+ ++++L S+ IE E A I ++QK +I E+
Sbjct: 557 LEGDLKLAQESTMDNENDKQQLDEKLEKKEFEISNLISK-IEDEQAVEI-QLQK-KIKEL 613
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL 478
+ + ++ E E K K + D+ R+L++ +++ A Q EL
Sbjct: 614 QARI-----EELGEEIEAERASRAKAEKQRSDLSRELEE---ISERLEEAGGATSAQVEL 665
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
++ E E +KLR + +A D++ E ++ +L KL K
Sbjct: 666 NKKR-EAEFQKLRRDL--EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKE 722
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS--LSEKDNKLTELVSTINGLKEENN 596
K E + + +E I K + K+ + L +SE K E IN L +
Sbjct: 723 K-SELKMETDDLSSNAEAISKAKGNLEKDGGRSLEDQVSELKTKEEEQQRLINDLTAQRA 781
Query: 597 SLKSLNDVITR---EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
L++ +R EK+ S+L RS Q Q +++++K +
Sbjct: 782 RLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ---QIEELKHQLEEETKAKNALAHALQS 838
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI---KTHEKTAEIQN-RMIMRLQKQIQE 709
+ L EQ +E E R S+ + +T+ +T IQ + +K++ +
Sbjct: 839 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTNTETDAIQRTEELEEAKKKLAQ 898
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
+ E +N E K+ V+DL E N D + ++ S+
Sbjct: 899 RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSE 958
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ + T +E+ D E + ++ + E
Sbjct: 959 WKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQ-------E 1011
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDE-CETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+S L E++ +++ +L++ K+++ E CE A L+E + + + L ++ +++
Sbjct: 1012 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA-LEEAEASLEHEEGKILRIQLELNQ 1070
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM--SYDAEVEKNKRLMKTIEEL 946
+K ++ K A+ D+ N H+ VV+ M + DAE+ ++ +++
Sbjct: 1071 VKSEV--------DRKIAEKDEEIDQLKRN-HTRVVETMQSTLDAEIRSRNDALRVKKKM 1121
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
+ DL ++ A + + + + L++ + L++ + ++L E+
Sbjct: 1122 ---EGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVE 1178
Query: 1007 EYLKQREEQCKRLKEAKIALEIVDKLSNQKV--ALEK-QIESLSNTPVSNSTMYVATGSA 1063
+ + + L E K++ Q++ A E+ Q+ NT + N+ + +
Sbjct: 1179 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1238
Query: 1064 IVQNQQITDVMKENQKLKKMNAKLIT 1089
+Q+ ++ +V++E++ ++ K IT
Sbjct: 1239 QLQS-EVEEVIQESRNAEEKAKKAIT 1263
Score = 42.3 bits (95), Expect = 0.009
Identities = 70/396 (17%), Positives = 154/396 (38%), Gaps = 39/396 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR--DLLMSQIKSLEMENL 120
++ + E LE G++ I+ + + ++ + I E L + + +E
Sbjct: 1043 IQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQS 1102
Query: 121 TKDKEIKNLTDSLKTKSKK---INELQEENDTLSNLIME---NVTESDNLNKE----VDD 170
T D EI++ D+L+ K K +NE++ + + + L E N + + KE +DD
Sbjct: 1103 TLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDD 1162
Query: 171 LKKNNECLTQKCIDLEKLVN----------------ESENKIGPKNICAQCKLKENLIQS 214
+ E L ++ +E+ N E KI + + + + L+ +
Sbjct: 1163 ALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASE-RVQLLHT 1221
Query: 215 LHIGYDNTLSKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKN---H 269
+ NT KL +S S + + + D + E+ ++ H
Sbjct: 1222 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1281
Query: 270 LELHEPNMTM---DLDEKLGENNEFETKA-VKVMSEIKRNLNSLSEQLINNESKKSKDHI 325
LE + N+ DL +L E + K K + +++ + L + + NE K++ + +
Sbjct: 1282 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE-VENEQKRNAEAV 1340
Query: 326 DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELK 385
+ V + + T + + ++++K Q + + + + N S+ +
Sbjct: 1341 KGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1400
Query: 386 SVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
+ +L + E+ N LR++ +H SA
Sbjct: 1401 KLQHELEEAEERADIAESQVNKLRVKSREVHTKISA 1436
>BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2,
skeletal muscle, adult protein.
Length = 1941
Score = 94.7 bits (225), Expect = 2e-18
Identities = 198/1088 (18%), Positives = 448/1088 (41%), Gaps = 78/1088 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 888 KEKNDLQLQVQAEAEGLADAE------ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE 941
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 942 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ A+ K
Sbjct: 1002 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL-EQEKKLRMDLERAKRK 1060
Query: 207 LKENL---------IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ-----SELDAG 252
L+ +L I++ D L K IS+ + + +Q EL A
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLD---EKLGENNEFETKAV----KVMSEIKRN 305
E+ +E E + + E +++ +L+ E+L E + + K +E ++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI-DLD 364
L E + +E+ + ++ DS +A L + ++ + K +I DL
Sbjct: 1181 RRDLEEATLQHEATAATLR-KKHADS-VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
+E +K +G+L + +++ ++L+ L S+ E++ N L Q+ R+ S +
Sbjct: 1239 SNVETVSKAKGNLEKM---CRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ +KE + ++ + +++ ++ R L++++ A + + +L R YE
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIE-ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYE 1354
Query: 485 IEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVD 541
E+E K L+ +KA EE K L + L + + V+
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 542 ENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
A+L K L E++ L + + + +L +K ++++ EE ++
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1474
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ +E + +EL + +++ +L+ +K + E
Sbjct: 1475 ASQ---KEARSLGTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGK 1527
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+ + +K+Q E++ C L+ ++ E + E + I+R+Q ++ +++ E + K
Sbjct: 1528 RIHELEKIKKQVEQE--KC-ELQAALEEAEASLEHEEGKILRIQLEL---NQVKSEVDRK 1581
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+ E + + LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDLNEME---IQL 1635
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSC 840
D L + + + K ++++ + + L+ +
Sbjct: 1636 NHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEEL 1694
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
+ L+ + K + E +E +Q Q L K LE +S ++ ++
Sbjct: 1695 RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEA 1754
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQDLKNTVTK 959
R A+ + A D A + + A +E+ K+ M +T+++L+ + + +
Sbjct: 1755 RNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE----- 1807
Query: 960 MQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
Q A++ K+ ++ EA+ +ELE + ++E + + K L + E Q EE K
Sbjct: 1808 -QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 1019 LKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ + ++VDKL + + ++Q E +N + + + ++ D+ +
Sbjct: 1867 ILRLQ---DLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE--S 1921
Query: 1079 KLKKMNAK 1086
++ K+ K
Sbjct: 1922 QVNKLRVK 1929
Score = 93.5 bits (222), Expect = 4e-18
Identities = 192/1044 (18%), Positives = 428/1044 (40%), Gaps = 67/1044 (6%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE 86
L A+ + D +I+T K+Q I + + +E + E+ K KL E ++K+
Sbjct: 904 LADAEERCDQLIKT-----KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958
Query: 87 QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT----KSKKINE 142
LE + E + +++K+L E D+ I LT K + +++
Sbjct: 959 DIDDLELTLAKVEKEKHATE---NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN--KIGPKN 200
LQ E D ++ L + L ++VDDL+ + E + +DLE+ + E K+ ++
Sbjct: 1016 LQAEEDKVNTLTKAKI----KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 201 ICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS--TRYNKICTLQSELDAGREDCK- 257
I K+ L + L + +S L I D KI LQ+ ++ E+ +
Sbjct: 1072 IMDIENEKQQLDEKLK-KKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 258 ELCEDFTSIKNHLELHEP--NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN 315
E + K +L ++ L+E G + K +E ++ L E +
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQ 374
+E+ + ++ DS+ A L + ++ + K +ID L +E +K +
Sbjct: 1191 HEATAATLR-KKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 375 GDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELK 434
G+L + +++ ++L+ L S+ E++ N L Q+ R+ S + + +KE +
Sbjct: 1249 GNLEKMC---RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 435 EILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE-KLRLE 493
++ + +++ ++ R L++++ A + + +L R YE E+E K L+
Sbjct: 1306 QLSRGKQAFTQQIE-ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVDENNANLNLIK 551
+KA EE K L + L + + V+ A+L K
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 552 I-LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE 610
L E++ L + + + +L +K ++++ EE ++ + +E
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ---KEAR 1481
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ +EL + +++ +L+ +K + E + + +K+
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 671 QCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA 730
Q E++ C L+ ++ E + E + I+R+Q ++ + E + K+ E + +
Sbjct: 1538 QVEQEK--CE-LQAALEEAEASLEHEEGKILRIQLELNQVKS---EVDRKIAEKDEEIDQ 1591
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1592 LKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDLNEME---IQLNHANRMAAEA 1645
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
D L + + + K ++++ + + L+ + + L+ +
Sbjct: 1646 LRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRATLEQTERS 1704
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
K + E +E +Q Q L K LE +S ++ ++ R A+ + A
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE--EKAK 1762
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEELRYKKQD-----LKNTVTKMQKAM 964
D A + + A +E+ K+ M+ T+++L+ + + LK ++QK
Sbjct: 1763 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE 1822
Query: 965 EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL----K 1020
+ + + E E+++K + L + ++R KEL + E + + + ++ +L K
Sbjct: 1823 ARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 1021 EAKIALEIVDKLSNQKVALEKQIE 1044
K E ++ SN +A ++++
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFRKLQ 1906
Score = 77.4 bits (182), Expect = 3e-13
Identities = 96/520 (18%), Positives = 210/520 (40%), Gaps = 25/520 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
A+ E++M ++ E+ K+ + ++ ++E L+ + +EK +++ + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKE---LEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
D++ + + L + L+++C E +D LE+
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
+ EK + L +++ D ET + +LT + +AL+ + + DL++
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLTKEKKALQEAHQQTLDDLQA 1018
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ VN LT K +E ++ +LE + E+ + +E
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078
Query: 805 NRDLGENPKLDDSPKRSI-SVISDSEV--SQLKERLLSCQQELDDLKERYKELDDECETC 861
+ L E K + ++ S I D + QL++++ Q +++L+E E++ E +
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE---EIEAERASR 1135
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
A+ ++R + L++ LE+ QI + +R+A+F + + +E +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEA 1193
Query: 922 VVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ E+ L + ++L +K ++K + + +E +K E
Sbjct: 1194 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK 1253
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LED +EL+ ++ + L + L+ + R + K AL V +LS K
Sbjct: 1254 MCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL--VSQLSRGK 1311
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
A +QIE L A A+ ++ D+++E
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLRE 1351
Score = 65.3 bits (152), Expect = 1e-09
Identities = 115/598 (19%), Positives = 250/598 (41%), Gaps = 38/598 (6%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 949 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + +L + E Q +LE S + K+ +L++ K
Sbjct: 1008 AHQQ------TLDDLQAEEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKLRMDLERAKRK 1060
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE----QCEEKTRDCSRLEINIKTHEKT 692
+ + K L++ L KE + K D L I ++ +K
Sbjct: 1061 L----EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ--KKI 1114
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSR 746
E+Q R I L+++I+ + + E + ++L+ + E + + +A ++ R
Sbjct: 1115 KELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1173
Query: 747 EAVNQLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGD 803
EA Q ++DL E + + +R + +V +
Sbjct: 1174 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 804 ENRDLGENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
E DL N + K ++ + + ++S+LK + Q+ ++DL + L E
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGE 1292
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ L E++ ++L + K + QQ+ LK Q+ ++ ++ + A ++ D L
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL--EEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 921 SVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ AE+++ T E +++ + + + + ++ E K + +A +
Sbjct: 1351 EQYEEEQESKAELQRALSKANT-EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH 1409
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVAL 1039
+E A+ L++ + L E E +++ C L K+ + +I+ + +
Sbjct: 1410 VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET 1469
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
++E+ S T +A ++ Q+ + +EN+ L++ + L + GK
Sbjct: 1470 HAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Score = 64.1 bits (149), Expect = 3e-09
Identities = 194/984 (19%), Positives = 390/984 (39%), Gaps = 77/984 (7%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLN-KEVDDLKKNNECLTQKCI 183
+IK L S +T+ K++ ++EE + + + ++ + L K V LK+ N+ Q
Sbjct: 841 KIKPLLKSAETE-KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ E L + E C Q +K + I ++ I+ T+ + K+
Sbjct: 900 EAEGLADAEER-------CDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKK-RKLE 950
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI- 302
SEL +D + K+ E N+T ++ L E TK K + E
Sbjct: 951 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAH 1009
Query: 303 KRNLNSL-SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
++ L+ L +E+ N K+K +++ D L L+ E + ++ K +
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE------KKLRMDLERAKRKLEG 1063
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
DL E ++ + + +LK ++++L S+ IE E A I ++QK +I E+ +
Sbjct: 1064 DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK-IEDEQALGI-QLQK-KIKELQAR 1120
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRT 481
+ + E E++ K K + D+ R+L++ +++ A Q E+++
Sbjct: 1121 IE----ELEEEIEAERASRA-KAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNKK 1172
Query: 482 DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD 541
E E +K+R + +A D++ E ++ +L KL K K
Sbjct: 1173 R-EAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK-S 1228
Query: 542 ENNANLNLIKILSEEIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTINGLKEENNSLKS 600
E ++ + E + K + K + LSE +K E IN L + L++
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288
Query: 601 LNDVITR---EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE 657
+ +R EKE S+L R Q Q EL + + + D
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN-RMIMRLQKQIQEDDKLFIE 716
+ E+ K + + + +T +T IQ + +K++ + + E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+N E K+ V+DL E N D + ++ ++ + +
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1468
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
T +E+ D E K ++ + E+S L E+
Sbjct: 1469 THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ-------EISDLTEQ 1521
Query: 837 LLSCQQELDDLKERYKELDDE-CETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
+ + + +L++ K+++ E CE A L+E + + + L ++ +++ +K ++
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAA-LEEAEASLEHEEGKILRIQLELNQVKSEV-- 1578
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRM--SYDAEVEKNK---RLMKTIE-ELRYK 949
K A+ D+ N H +V+ M + DAE+ RL K +E +L
Sbjct: 1579 ------DRKIAEKDEEIDQLKRN-HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEEC---ETCA 1006
+ L + +A+ Y + + L+D E+LK++ ++ +
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 1007 EYLKQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
E L+ EQ +R + KIA E++D ++++V Q+ NT + N+ + T + +
Sbjct: 1692 EELRATLEQTERSR--KIAEQELLD--ASERV----QLLHTQNTSLINTKKKLETDISQM 1743
Query: 1066 QNQQITDVMKENQKLKKMNAKLIT 1089
Q ++ D+++E + ++ K IT
Sbjct: 1744 QG-EMEDILQEARNAEEKAKKAIT 1766
Score = 58.0 bits (134), Expect = 2e-07
Identities = 76/408 (18%), Positives = 172/408 (42%), Gaps = 15/408 (3%)
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVK 740
+L IK K+AE + M ++++ Q+ + E K EL K L ++ +
Sbjct: 837 KLFFKIKPLLKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 741 DLESSREAVNQLTTQKD-LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+++ E + + D L++ +I +LE+ I+ T
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKI-QLEAKIKE---VTERAEDEEEINAELTAKKRKLED 951
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
+ +D+ ++ +L + ++++V L E + + + L + K L + +
Sbjct: 952 ECSELKKDI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
+ LQ +++ L K K+ LEQQV +L+ + ++ + + A + D A
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
+ ++ + EK K+ I L+ K +D + ++QK +++ + +E E +
Sbjct: 1071 SIMDIENEKQQLD-EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE---E 1126
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL 1039
E+E +A + +++ +L E E +E L E+ A+I + + QK+
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + +L + + + S +QI ++ + QKL+K +++
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1230
>AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa
protein.
Length = 1941
Score = 94.7 bits (225), Expect = 2e-18
Identities = 198/1088 (18%), Positives = 448/1088 (41%), Gaps = 78/1088 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 888 KEKNDLQLQVQAEAEGLADAE------ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE 941
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 942 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ A+ K
Sbjct: 1002 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL-EQEKKLRMDLERAKRK 1060
Query: 207 LKENL---------IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ-----SELDAG 252
L+ +L I++ D L K IS+ + + +Q EL A
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLD---EKLGENNEFETKAV----KVMSEIKRN 305
E+ +E E + + E +++ +L+ E+L E + + K +E ++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI-DLD 364
L E + +E+ + ++ DS +A L + ++ + K +I DL
Sbjct: 1181 RRDLEEATLQHEATAATLR-KKHADS-VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
+E +K +G+L + +++ ++L+ L S+ E++ N L Q+ R+ S +
Sbjct: 1239 SNVETVSKAKGNLEKM---CRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ +KE + ++ + +++ ++ R L++++ A + + +L R YE
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIE-ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYE 1354
Query: 485 IEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVD 541
E+E K L+ +KA EE K L + L + + V+
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 542 ENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
A+L K L E++ L + + + +L +K ++++ EE ++
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1474
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ +E + +EL + +++ +L+ +K + E
Sbjct: 1475 ASQ---KEARSLGTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGK 1527
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+ + +K+Q E++ C L+ ++ E + E + I+R+Q ++ +++ E + K
Sbjct: 1528 RIHELEKIKKQVEQE--KC-ELQAALEEAEASLEHEEGKILRIQLEL---NQVKSEVDRK 1581
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+ E + + LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDLNEME---IQL 1635
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSC 840
D L + + + K ++++ + + L+ +
Sbjct: 1636 NHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEEL 1694
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
+ L+ + K + E +E +Q Q L K LE +S ++ ++
Sbjct: 1695 RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEA 1754
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQDLKNTVTK 959
R A+ + A D A + + A +E+ K+ M +T+++L+ + + +
Sbjct: 1755 RNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE----- 1807
Query: 960 MQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
Q A++ K+ ++ EA+ +ELE + ++E + + K L + E Q EE K
Sbjct: 1808 -QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 1019 LKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ + ++VDKL + + ++Q E +N + + + ++ D+ +
Sbjct: 1867 ILRLQ---DLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAE--S 1921
Query: 1079 KLKKMNAK 1086
++ K+ K
Sbjct: 1922 QVNKLRVK 1929
Score = 93.5 bits (222), Expect = 4e-18
Identities = 192/1044 (18%), Positives = 428/1044 (40%), Gaps = 67/1044 (6%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE 86
L A+ + D +I+T K+Q I + + +E + E+ K KL E ++K+
Sbjct: 904 LADAEERCDQLIKT-----KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958
Query: 87 QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT----KSKKINE 142
LE + E + +++K+L E D+ I LT K + +++
Sbjct: 959 DIDDLELTLAKVEKEKHATE---NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN--KIGPKN 200
LQ E D ++ L + L ++VDDL+ + E + +DLE+ + E K+ ++
Sbjct: 1016 LQAEEDKVNTLTKAKI----KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 201 ICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS--TRYNKICTLQSELDAGREDCK- 257
I K+ L + L + +S L I D KI LQ+ ++ E+ +
Sbjct: 1072 IMDIENEKQQLDEKLK-KKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 258 ELCEDFTSIKNHLELHEP--NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN 315
E + K +L ++ L+E G + K +E ++ L E +
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQ 374
+E+ + ++ DS+ A L + ++ + K +ID L +E +K +
Sbjct: 1191 HEATAATLR-KKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 375 GDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELK 434
G+L + +++ ++L+ L S+ E++ N L Q+ R+ S + + +KE +
Sbjct: 1249 GNLEKMC---RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 435 EILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE-KLRLE 493
++ + +++ ++ R L++++ A + + +L R YE E+E K L+
Sbjct: 1306 QLSRGKQAFTQQIE-ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVDENNANLNLIK 551
+KA EE K L + L + + V+ A+L K
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 552 I-LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE 610
L E++ L + + + +L +K ++++ EE ++ + +E
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ---KEAR 1481
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ +EL + +++ +L+ +K + E + + +K+
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 671 QCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA 730
Q E++ C L+ ++ E + E + I+R+Q ++ + E + K+ E + +
Sbjct: 1538 QVEQEK--CE-LQAALEEAEASLEHEEGKILRIQLELNQVKS---EVDRKIAEKDEEIDQ 1591
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1592 LKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDLNEME---IQLNHANRMAAEA 1645
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
D L + + + K ++++ + + L+ + + L+ +
Sbjct: 1646 LRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRATLEQTERS 1704
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
K + E +E +Q Q L K LE +S ++ ++ R A+ + A
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE--EKAK 1762
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEELRYKKQD-----LKNTVTKMQKAM 964
D A + + A +E+ K+ M+ T+++L+ + + LK ++QK
Sbjct: 1763 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE 1822
Query: 965 EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL----K 1020
+ + + E E+++K + L + ++R KEL + E + + + ++ +L K
Sbjct: 1823 ARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 1021 EAKIALEIVDKLSNQKVALEKQIE 1044
K E ++ SN +A ++++
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFRKLQ 1906
Score = 77.4 bits (182), Expect = 3e-13
Identities = 96/520 (18%), Positives = 210/520 (40%), Gaps = 25/520 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
A+ E++M ++ E+ K+ + ++ ++E L+ + +EK +++ + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKE---LEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
D++ + + L + L+++C E +D LE+
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
+ EK + L +++ D ET + +LT + +AL+ + + DL++
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLTKEKKALQEAHQQTLDDLQA 1018
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ VN LT K +E ++ +LE + E+ + +E
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078
Query: 805 NRDLGENPKLDDSPKRSI-SVISDSEV--SQLKERLLSCQQELDDLKERYKELDDECETC 861
+ L E K + ++ S I D + QL++++ Q +++L+E E++ E +
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE---EIEAERASR 1135
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
A+ ++R + L++ LE+ QI + +R+A+F + + +E +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEA 1193
Query: 922 VVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ E+ L + ++L +K ++K + + +E +K E
Sbjct: 1194 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK 1253
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LED +EL+ ++ + L + L+ + R + K AL V +LS K
Sbjct: 1254 MCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL--VSQLSRGK 1311
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
A +QIE L A A+ ++ D+++E
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLRE 1351
Score = 65.3 bits (152), Expect = 1e-09
Identities = 115/598 (19%), Positives = 250/598 (41%), Gaps = 38/598 (6%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 949 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + +L + E Q +LE S + K+ +L++ K
Sbjct: 1008 AHQQ------TLDDLQAEEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKLRMDLERAKRK 1060
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE----QCEEKTRDCSRLEINIKTHEKT 692
+ + K L++ L KE + K D L I ++ +K
Sbjct: 1061 L----EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ--KKI 1114
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSR 746
E+Q R I L+++I+ + + E + ++L+ + E + + +A ++ R
Sbjct: 1115 KELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1173
Query: 747 EAVNQLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGD 803
EA Q ++DL E + + +R + +V +
Sbjct: 1174 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 804 ENRDLGENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
E DL N + K ++ + + ++S+LK + Q+ ++DL + L E
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGE 1292
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ L E++ ++L + K + QQ+ LK Q+ ++ ++ + A ++ D L
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL--EEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 921 SVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ AE+++ T E +++ + + + + ++ E K + +A +
Sbjct: 1351 EQYEEEQESKAELQRALSKANT-EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH 1409
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVAL 1039
+E A+ L++ + L E E +++ C L K+ + +I+ + +
Sbjct: 1410 VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET 1469
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
++E+ S T +A ++ Q+ + +EN+ L++ + L + GK
Sbjct: 1470 HAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Score = 64.1 bits (149), Expect = 3e-09
Identities = 194/984 (19%), Positives = 390/984 (39%), Gaps = 77/984 (7%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLN-KEVDDLKKNNECLTQKCI 183
+IK L S +T+ K++ ++EE + + + ++ + L K V LK+ N+ Q
Sbjct: 841 KIKPLLKSAETE-KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ E L + E C Q +K + I ++ I+ T+ + K+
Sbjct: 900 EAEGLADAEER-------CDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKK-RKLE 950
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI- 302
SEL +D + K+ E N+T ++ L E TK K + E
Sbjct: 951 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAH 1009
Query: 303 KRNLNSL-SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
++ L+ L +E+ N K+K +++ D L L+ E + ++ K +
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE------KKLRMDLERAKRKLEG 1063
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
DL E ++ + + +LK ++++L S+ IE E A I ++QK +I E+ +
Sbjct: 1064 DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK-IEDEQALGI-QLQK-KIKELQAR 1120
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRT 481
+ + E E++ K K + D+ R+L++ +++ A Q E+++
Sbjct: 1121 IE----ELEEEIEAERASRA-KAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNKK 1172
Query: 482 DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD 541
E E +K+R + +A D++ E ++ +L KL K K
Sbjct: 1173 R-EAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK-S 1228
Query: 542 ENNANLNLIKILSEEIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTINGLKEENNSLKS 600
E ++ + E + K + K + LSE +K E IN L + L++
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288
Query: 601 LNDVITR---EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE 657
+ +R EKE S+L R Q Q EL + + + D
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN-RMIMRLQKQIQEDDKLFIE 716
+ E+ K + + + +T +T IQ + +K++ + + E
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+N E K+ V+DL E N D + ++ ++ + +
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1468
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
T +E+ D E K ++ + E+S L E+
Sbjct: 1469 THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ-------EISDLTEQ 1521
Query: 837 LLSCQQELDDLKERYKELDDE-CETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
+ + + +L++ K+++ E CE A L+E + + + L ++ +++ +K ++
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAA-LEEAEASLEHEEGKILRIQLELNQVKSEV-- 1578
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRM--SYDAEVEKNK---RLMKTIE-ELRYK 949
K A+ D+ N H +V+ M + DAE+ RL K +E +L
Sbjct: 1579 ------DRKIAEKDEEIDQLKRN-HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEEC---ETCA 1006
+ L + +A+ Y + + L+D E+LK++ ++ +
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 1007 EYLKQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
E L+ EQ +R + KIA E++D ++++V Q+ NT + N+ + T + +
Sbjct: 1692 EELRATLEQTERSR--KIAEQELLD--ASERV----QLLHTQNTSLINTKKKLETDISQM 1743
Query: 1066 QNQQITDVMKENQKLKKMNAKLIT 1089
Q ++ D+++E + ++ K IT
Sbjct: 1744 QG-EMEDILQEARNAEEKAKKAIT 1766
Score = 58.0 bits (134), Expect = 2e-07
Identities = 76/408 (18%), Positives = 172/408 (42%), Gaps = 15/408 (3%)
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVK 740
+L IK K+AE + M ++++ Q+ + E K EL K L ++ +
Sbjct: 837 KLFFKIKPLLKSAETEKEMAT-MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 741 DLESSREAVNQLTTQKD-LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+++ E + + D L++ +I +LE+ I+ T
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKI-QLEAKIKE---VTERAEDEEEINAELTAKKRKLED 951
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
+ +D+ ++ +L + ++++V L E + + + L + K L + +
Sbjct: 952 ECSELKKDI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1010
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
+ LQ +++ L K K+ LEQQV +L+ + ++ + + A + D A
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
+ ++ + EK K+ I L+ K +D + ++QK +++ + +E E +
Sbjct: 1071 SIMDIENEKQQLD-EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE---E 1126
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL 1039
E+E +A + +++ +L E E +E L E+ A+I + + QK+
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + +L + + + S +QI ++ + QKL+K +++
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1230
>AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/d
protein.
Length = 1939
Score = 93.9 bits (223), Expect = 3e-18
Identities = 194/1088 (17%), Positives = 451/1088 (41%), Gaps = 78/1088 (7%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 886 QEKNDLQLQVQAEADSLADAE------ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE 939
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E KI A+ K
Sbjct: 1000 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL-EQEKKIRMDLERAKRK 1058
Query: 207 LKEN--LIQSLHIGYDNTLSKLNRSI--SDSNTSTRYNKI-------CTLQ---SELDAG 252
L+ + L Q + +N +L+ + + S +KI LQ EL A
Sbjct: 1059 LEGDLKLAQESAMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQAR 1118
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLD---EKLGENNEFETKAV----KVMSEIKRN 305
E+ +E E + + E +++ +L+ E+L E + + K +E ++
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1178
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI-DLD 364
L E + +E+ + ++ DS +A L + ++ + K +I DL
Sbjct: 1179 RRDLEEATLQHEATAATLR-KKHADS-VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1236
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
+E +K +G+L + +++ ++L+ + ++ E++ N L Q+ R+ S +
Sbjct: 1237 SNMETVSKAKGNLEKM---CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ +K+ + ++ + +++ ++ R L++++ A + + +L R YE
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIE-ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE 1352
Query: 485 IEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVD 541
E+E K L+ +KA EE K L + L + + V+
Sbjct: 1353 EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 542 ENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
A+L K L E++ L I + + +L +K ++++ EE ++
Sbjct: 1413 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1472
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ +E + ++EL + +++ +L+ +K + E
Sbjct: 1473 ASQ---KESRSLSTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGK 1525
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+ + +K+Q E++ S L+ ++ E + E + I+R+Q ++ +++ E + K
Sbjct: 1526 RIHELEKIKKQVEQEK---SELQAALEEAEASLEHEEGKILRIQLEL---NQVKSEVDRK 1579
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+ E + + +KR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1580 IAEKDEEIDQMKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDLNEME---IQL 1633
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSC 840
D L + + + K ++++ + + L+ +
Sbjct: 1634 NHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEEL 1692
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
+ L+ + K + E +E +Q Q L K LE +S ++ ++ + ++
Sbjct: 1693 RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM--EDIIQ 1750
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTK 959
+ A D A + + A +E+ K L +T+++L+++ + +
Sbjct: 1751 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE----- 1805
Query: 960 MQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
Q A++ K+ ++ EA+ +ELE + ++E + + K L + E Q EE K
Sbjct: 1806 -QLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKN 1864
Query: 1019 LKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ + ++VDKL + + ++Q E N + + + + ++ D+ +
Sbjct: 1865 ILRLQ---DLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAE--S 1919
Query: 1079 KLKKMNAK 1086
++ K+ K
Sbjct: 1920 QVNKLRVK 1927
Score = 90.6 bits (215), Expect = 3e-17
Identities = 183/1022 (17%), Positives = 421/1022 (41%), Gaps = 64/1022 (6%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDI 84
+ L A+ + D +I+T K+Q I + + +E + E+ K KL E ++
Sbjct: 900 DSLADAEERCDQLIKT-----KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT----KSKKI 140
K+ LE + E + +++K+L E D+ I LT K + +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATE---NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 141 NELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN--KIGP 198
++LQ E D ++ L + L ++VDDL+ + E + +DLE+ + E K+
Sbjct: 1012 DDLQAEEDKVNTLTKAKI----KLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQ 1067
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICTLQSELDAGREDC 256
++ K+ L + L + +S L I D KI LQ+ ++ E+
Sbjct: 1068 ESAMDIENDKQQLDEKLK-KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEI 1126
Query: 257 K-ELCEDFTSIKNHLELHEP--NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
+ E + K +L ++ L+E G + K +E ++ L E
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTK 372
+ +E+ + ++ DS+ A L + ++ + K +ID L +E +K
Sbjct: 1187 LQHEATAATLR-KKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK 1244
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
+G+L + +++ ++L+ + ++ E++ N L Q+ R+ S + + +K+
Sbjct: 1245 AKGNLEKMC---RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE-KLR 491
+ ++ + +++ ++ R L++++ A + + +L R YE E+E K
Sbjct: 1302 VSQLSRGKQAFTQQIE-ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 492 LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVDENNANLNL 549
L+ +KA EE K L + L + + V+ A+L
Sbjct: 1361 LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420
Query: 550 IKI-LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
K L E++ L I + + +L +K ++++ EE ++ + +E
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ---KE 1477
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
+ ++EL + +++ +L+ +K + E + + +
Sbjct: 1478 SRSLSTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHELEKI 1533
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K+Q E++ S L+ ++ E + E + I+R+Q ++ + E + K+ E +
Sbjct: 1534 KKQVEQEK---SELQAALEEAEASLEHEEGKILRIQLELNQVKS---EVDRKIAEKDEEI 1587
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
+ +KR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1588 DQMKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDLNEME---IQLNHANRMAA 1641
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLK 848
D L + + + K ++++ + + L+ + + L+ +
Sbjct: 1642 EALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRATLEQTE 1700
Query: 849 ERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADV 908
K + E +E +Q Q L K LE +S ++ ++ R A+ +
Sbjct: 1701 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAE--EK 1758
Query: 909 AVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKTIEELRYKKQD-----LKNTVTKMQK 962
A D A + + A +E+ K+ L +T+++L+++ + LK ++QK
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 963 AMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA 1022
+ + + E E+++K + L + +++ KEL + E + + + ++ +L +A
Sbjct: 1819 LEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKL-QA 1877
Query: 1023 KI 1024
K+
Sbjct: 1878 KV 1879
Score = 76.6 bits (180), Expect = 5e-13
Identities = 95/520 (18%), Positives = 206/520 (39%), Gaps = 25/520 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
A+ E++M ++ E+ K E ++ ++E L+ + +EK +++ +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKE---LEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
D++ + + L + L+++C E +D LE+
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
+ EK + L +++ D ET + +LT + +AL+ + + DL++
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLTKEKKALQEAHQQTLDDLQA 1016
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ VN LT K +E ++ +LE + E+ + ++
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIEND 1076
Query: 805 NRDLGENPKLDDSPKRSI-SVISDSEV--SQLKERLLSCQQELDDLKERYKELDDECETC 861
+ L E K + + S I D + QL++++ Q +++L+E E++ E +
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE---EIEAERASR 1133
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
A+ ++R + L++ LE+ QI + +R+A+F + + +E +
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEA 1191
Query: 922 VVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ E+ L + ++L +K ++K + + ME +K E
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LED +E++ ++ + L + L+ + R + K L V +LS K
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL--VSQLSRGK 1309
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
A +QIE L A A+ ++ D+++E
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE 1349
Score = 66.5 bits (155), Expect = 5e-10
Identities = 191/986 (19%), Positives = 385/986 (39%), Gaps = 81/986 (8%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
+IK L S +T+ + N +E T L + K V +++ N+ Q +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 185 LEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICT 244
+ L + E C Q +K + I ++ I+ T+ + K+
Sbjct: 899 ADSLADAEER-------CDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKK-RKLED 949
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI-K 303
SEL +D + K+ E N+T ++ L E TK K + E +
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQ 1008
Query: 304 RNLNSL-SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+ L+ L +E+ N K+K +++ D L L+ E + ++ K + D
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE------KKIRMDLERAKRKLEGD 1062
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L E ++ D + +LK +++ L S+ IE E A +++QK +I E+ + +
Sbjct: 1063 LKLAQESAMDIENDKQQLDEKLKKKEFEMSGLQSK-IEDEQALG-MQLQK-KIKELQARI 1119
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRT- 481
+ E E++ K K + D+ R+L++ +++ A Q E+++
Sbjct: 1120 E----ELEEEIEAERASRA-KAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNKKR 1171
Query: 482 DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN--EVKSLHEELTKLYKSK 539
+ E +K + LE T + + E+ N VK E+ K +
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1231
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+D+ +N+ + ++ + A+ E+++ + K+ + L IN L + L+
Sbjct: 1232 IDDLASNMETVSKAKGNLEKMCRAL---EDQLSEIKTKEEEQQRL---INDLTAQRARLQ 1285
Query: 600 SLNDVITR---EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + +R EK+T S+L R Q Q EL + + + D
Sbjct: 1286 TESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD 1345
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN-RMIMRLQKQIQEDDKLFI 715
+ E+ K + + + +T +T IQ + +K++ + +
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E +N E K+ V+DL E N D + ++ ++ + +
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
T +E+ D E K ++ + E+S L E
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQ-------EISDLTE 1518
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN-LKEQIR 894
++ + + +L++ K+++ QE+ E A L++ + SLE + L+ Q+
Sbjct: 1519 QIAEGGKRIHELEKIKKQVE----------QEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 895 TQQ-PVERQAKFADVAVNTDEDWANLHSVVVDRM--SYDAEVEKNK---RLMKTIE-ELR 947
Q E K A+ D+ N H +V+ M + DAE+ RL K +E +L
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRN-HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEEC---ET 1004
+ L + +A+ Y + + L+D E+LK++ ++ +
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687
Query: 1005 CAEYLKQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSA 1063
E L+ EQ +R + KIA E++D ++++V Q+ NT + N+ + T +
Sbjct: 1688 EIEELRATLEQTERSR--KIAEQELLD--ASERV----QLLHTQNTSLINTKKKLETDIS 1739
Query: 1064 IVQNQQITDVMKENQKLKKMNAKLIT 1089
+Q ++ D+++E + ++ K IT
Sbjct: 1740 QIQG-EMEDIIQEARNAEEKAKKAIT 1764
Score = 64.9 bits (151), Expect = 2e-09
Identities = 119/600 (19%), Positives = 255/600 (42%), Gaps = 42/600 (7%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 947 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + +L + E Q +LE S + K+ +L++ K
Sbjct: 1006 AHQQ------TLDDLQAEEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKIRMDLERAKRK 1058
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE----QCEEKTRDCSRLEINIKTHEKT 692
+ + K L++ L KE + K D L + ++ +K
Sbjct: 1059 L----EGDLKLAQESAMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQ--KKI 1112
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSR 746
E+Q R I L+++I+ + + E + ++L+ + E + + +A ++ R
Sbjct: 1113 KELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 747 EAVNQLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGD 803
EA Q ++DL E + + +R + +V +
Sbjct: 1172 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 804 ENRDLGENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
E DL N + K ++ + + ++S++K + Q+ ++DL + L E
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE 1290
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ L E+D ++L + K + QQ+ LK Q+ ++ ++ ++ A ++ D L
Sbjct: 1291 YSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL--EEEIKAKSALAHALQSSRHDCDLLR 1348
Query: 921 SVVVDRMSYDAEVEK-NKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
+ AE+++ + + + R K + D ++++A +K ++ ++ E
Sbjct: 1349 EQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKV 1037
+ + A LE+ KQR L E E +++ C L K+ + +I+ + +
Sbjct: 1409 EAVNAKCASLEKTKQR---LQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 1038 ALEKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
++E+ S ST +A ++ Q+ + +EN+ L++ + L + GK
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525
Score = 57.6 bits (133), Expect = 2e-07
Identities = 73/408 (17%), Positives = 175/408 (42%), Gaps = 15/408 (3%)
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVK 740
+L IK K+AE + M ++++ ++ + + E K EL K L ++ +
Sbjct: 835 KLYFKIKPLLKSAETEKEMA-NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 741 DLESSREAVNQLTTQKD-LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+++ +++ + D L++ +I +LE+ I+ T
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKI-QLEAKIKE---VTERAEDEEEINAELTAKKRKLED 949
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
+ +D+ ++ +L + ++++V L E + + + L + K L + +
Sbjct: 950 ECSELKKDI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
+ LQ +++ L K K+ LEQQV +L+ + ++ + + A + D A
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
++ ++ + EK K+ + L+ K +D + ++QK +++ + +E E +
Sbjct: 1069 SAMDIENDKQQLD-EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE---E 1124
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL 1039
E+E +A + +++ +L E E +E L E+ A+I + + QK+
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + +L + + + S +QI ++ + QKL+K +++
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1228
>Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein.
Length = 1937
Score = 93.1 bits (221), Expect = 5e-18
Identities = 188/1058 (17%), Positives = 439/1058 (41%), Gaps = 74/1058 (6%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K KND ++ QS L D+ + C+ L ++ ++ K+++++ + +E +
Sbjct: 885 KEKNDLQLQVQSEADSLADAE------ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE 938
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 939 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKE 998
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ A+ K
Sbjct: 999 KKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL-EQEKKLRMDLERAKRK 1057
Query: 207 LKEN--LIQSLHIGYDNTLSKLNRSI--SDSNTSTRYNKI-------CTLQ---SELDAG 252
L+ + L Q + +N +L+ + + S +KI LQ EL A
Sbjct: 1058 LEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQAR 1117
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ E E + + E +++ +L+E + E E A E+ + + ++
Sbjct: 1118 IEELGEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQVELNKKREAEFQK 1176
Query: 313 LINNESKKSKDHIDRYKDSLLAVLD--AEFG--TTSLDVFEILMDNIINKYQIDLDEI-- 366
L + + + H D AE G +L + ++ ++ +++ D++
Sbjct: 1177 LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSS 1236
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
E +K +G+L + +S+ ++++ L ++ E++ N L Q+ R+ + +
Sbjct: 1237 NAEAISKAKGNLEKM---CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ 1293
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ +K+ + ++ + +++ ++ L+++ A + + +L R YE
Sbjct: 1294 LDEKDALVSQLSRSKQASTQQIE-ELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE 1352
Query: 486 EKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL--YKSKVDE 542
E+E K L+ +KA EE K L + L + + V+
Sbjct: 1353 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNA 1412
Query: 543 NNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL 601
A+L K L E++ L + + ++ +L +K +++S K++ ++
Sbjct: 1413 KCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSE---WKQKYEETQAE 1469
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ +E + ++EL + V +++ +L+ ++ + + K +
Sbjct: 1470 LEASQKESRSLSTELFKVKNVYEESLDQLETLRRE---NKNLQQEISDLTEQIAEGGKQI 1526
Query: 662 LEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
E +K+Q E++ C ++ ++ E + E + I+R+Q ++ +++ E + K+
Sbjct: 1527 HELE-KIKKQVEQE--KC-EIQAALEEAEASLEHEEGKILRIQLEL---NQVKSEVDRKI 1579
Query: 722 NELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXX 781
E + + LKR++ V+ ++S+ +A ++ ++ D + + ++E D+ + +
Sbjct: 1580 AEKDEEIDQLKRNHTRVVETMQSTLDA--EIRSRNDALRVK-KKMEGDLNEME---IQLN 1633
Query: 782 XXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQ 841
+ L + + + K ++++ + + L+ +
Sbjct: 1634 HANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIV-ERRANLLQAEIEELW 1692
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVER 901
L+ + K + E +E +Q Q L K LE VS L+ ++ ++ ++
Sbjct: 1693 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV--EEVIQE 1750
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKM 960
+ A D A + + A +E+ K L +T+++L+++ + +
Sbjct: 1751 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE------ 1804
Query: 961 QKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
Q A++ K+ ++ EA+ +ELE + + E + + K L + E Q EE K +
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1864
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
+ ++VDKL + + ++Q E +N + +
Sbjct: 1865 LRLQ---DLVDKLQAKVKSYKRQAEEAEEQSNANLSKF 1899
Score = 81.4 bits (192), Expect = 2e-14
Identities = 107/529 (20%), Positives = 218/529 (41%), Gaps = 37/529 (6%)
Query: 555 EEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
+E+ +K K ++++ K +L E + T+ LKE+N+ L + E ++ A
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTL--LKEKND----LQLQVQSEADSLAD 903
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
ER Q+IK N +L+ ++ + L + L+++C E
Sbjct: 904 AEERCEQLIK-NKIQLEAKIKEV----------TERAEEEEEINAELTAKKRKLEDECSE 952
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
+D LE+ + EK + L +++ D ET + +L+ + +AL+
Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLSKEKKALQET 1005
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ + DL++ + VN LT K +E ++ +LE + E+ +
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1065
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
++ + L E KL+ ++IS E Q E + Q+++ +L+ R +EL
Sbjct: 1066 QESTMDMENDKQQLDE--KLEKKEFEISNLISKIEDEQAVE--IQLQKKIKELQARIEEL 1121
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKFADVAVNT 912
+E E + ++Q + L +E + +++ Q + +R+A+F + +
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL 1181
Query: 913 DEDWANLHSVVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
+E ++V A+ E+ L + ++L +K +LK + E
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
+K E + LED +EL+ ++ + L + L+ + R + K AL
Sbjct: 1242 SKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDAL- 1300
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
V +LS K A +QIE L + + A A+ ++ D+++E
Sbjct: 1301 -VSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE 1348
Score = 70.1 bits (164), Expect = 4e-11
Identities = 120/596 (20%), Positives = 249/596 (41%), Gaps = 34/596 (5%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 946 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE 1004
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + L T+ E Q +LE S + K+ +L++ K
Sbjct: 1005 THQQ------TLDDLQAEEDKVNILTKAKTK-LEQQVDDLEGSLEQEKKLRMDLERAKRK 1057
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ 696
+ + LE+ K D +EI ++ +K E+Q
Sbjct: 1058 LEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ--KKIKELQ 1115
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSREAVN 750
R I L ++I+ + + E + ++L+ + E + + +A +L REA
Sbjct: 1116 AR-IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEF 1174
Query: 751 QLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGDENRD 807
Q ++DL E + + + +R + ++ + E D
Sbjct: 1175 Q-KLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD 1233
Query: 808 LGENPKLDDSPKRSISVISDS---EVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
L N + K ++ + S +VS+LK + Q+ ++DL + L E +
Sbjct: 1234 LSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ 1293
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
L E+D ++L + K + QQ+ LK Q+ ++ + + A ++ D L
Sbjct: 1294 LDEKDALVSQLSRSKQASTQQIEELKHQL--EEETKAKNALAHALQSSRHDCDLLREQYE 1351
Query: 925 DRMSYDAEVEKN-KRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
+ AE+++ + + + R K + D ++++A +K ++ +E E + +
Sbjct: 1352 EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVN 1411
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVALEK 1041
A LE+ KQR L E E +++ C L K+ + +++ + + +
Sbjct: 1412 AKCASLEKTKQR---LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQA 1468
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
++E+ S ST + ++ Q+ + +EN+ L++ + L + GK
Sbjct: 1469 ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1524
Score = 66.5 bits (155), Expect = 5e-10
Identities = 189/1042 (18%), Positives = 394/1042 (37%), Gaps = 74/1042 (7%)
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL----SNLIMENVTESDNLNKEVDDL 171
E E T +E + D L K EL+E+ TL ++L ++ +E+D+L D
Sbjct: 849 EKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA----DA 904
Query: 172 KKNNECLTQKCIDLEKLVNE-SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI 230
++ E L + I LE + E +E + I A+ K+ ++ + S+L + I
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE-------DECSELKKDI 957
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL--HEPNMTMDLDEKLGEN 288
D + + ++ E A K L E+ + + E + ++ ++
Sbjct: 958 DDLELT-----LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINN--ESKKSKDHIDRYKDSLLAVLD-AEFGTTSL 345
+ E V ++++ K L + L + + KK + ++R K L L A+ T +
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 346 DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ + +D + K + ++ ++ K Q + ++K + ++ L + IE E A
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEE-IEAERAS 1131
Query: 406 NILRIQKER------IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQD- 458
+ +K+R + EIS + + + E+ K + KL+ D+ Q
Sbjct: 1132 RA-KAEKQRSDLSRELEEISERLE-EAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189
Query: 459 ---LPAHKKITILFDALITQYE-LSRTDYEIEKEK--LRLETGTAKAVXXXXXXXXXXXX 512
KK L Q + L R ++EKEK L++ET +
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDEN---NANLNLIKILSEEIDALKIAIAKNEE 569
+LE+ +E+K+ EE +L + +E DAL ++++++
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309
Query: 570 KMLS-LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA---SELERSCQVIKQ 625
+ E ++L E N L S + D++ + E + +EL+R+
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS 1369
Query: 626 NGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ K + D + EA+ +E A+ +C + RL+
Sbjct: 1370 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVE---AVNAKCASLEKTKQRLQN 1426
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
++ E N L K+ + DK+ E + K E + EA +++ + +L
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK 1486
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+ + Q + + L+ +I TEQ A
Sbjct: 1487 VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA 1546
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE--------L 854
E + + + ++ I + + S++ ++ +E+D LK + L
Sbjct: 1547 LEEAEA--SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTL 1604
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR----TQQPVERQAKFADVAV 910
D E + + L+ + + L + ++ L E +R TQ ++ D A+
Sbjct: 1605 DAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDAL 1664
Query: 911 NTDEDWANLHSVVVDRMSY-DAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYT 968
ED ++V R + AE+E+ ++ E R +Q+L + ++Q + T
Sbjct: 1665 RGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNT 1724
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ ++ ++E+EE+ Q + +E+ + E+ K+ ++ LE
Sbjct: 1725 SLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1784
Query: 1029 VDKLSNQKVA-LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ K Q V L+ +++ + + A V +++ ++ QK K
Sbjct: 1785 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV--RELEGEVENEQKRNAEAVKG 1842
Query: 1088 ITICKKRGKTGANRENEDPSDV 1109
+ ++R K + ED +V
Sbjct: 1843 LRKHERRVKELTYQTEEDRKNV 1864
Score = 54.8 bits (126), Expect = 2e-06
Identities = 187/992 (18%), Positives = 386/992 (38%), Gaps = 93/992 (9%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
+IK L S +T+ + +E T L + K V LK+ N+ Q +
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 185 LEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICT 244
+ L + E C Q +K + I ++ I+ T+ +
Sbjct: 898 ADSLADAEER-------CEQL-IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRK---- 945
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEP-NMTMDLDEKLGENNEFETKAVKVMSEIK 303
L+ E ++D +L + T K E H N +L E++ +E K K ++
Sbjct: 946 LEDECSELKKDIDDL--ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ 1003
Query: 304 RNLNSLSEQLINNESK-----KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ L E K K+K +++ D L L+ E + ++ K
Sbjct: 1004 ETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE------KKLRMDLERAKRK 1057
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ DL E ++ D + +L+ ++++L S+ IE E A I ++QK +I E+
Sbjct: 1058 LEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK-IEDEQAVEI-QLQK-KIKEL 1114
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL 478
+ + ++ E E K K + D+ R+L++ +++ A Q EL
Sbjct: 1115 QARI-----EELGEEIEAERASRAKAEKQRSDLSRELEE---ISERLEEAGGATSAQVEL 1166
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
++ E E +KLR + +A D++ E ++ +L KL K
Sbjct: 1167 NKKR-EAEFQKLRRDL--EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKE 1223
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAK---NEEKML-----SLSEKDNKLTELVSTING 590
K + +K+ ++++ + AI+K N EKM +SE K E IN
Sbjct: 1224 KSE--------LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIND 1275
Query: 591 LKEENNSLKSLNDVITR---EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
L + L++ +R EK+ S+L RS Q Q +++++K +
Sbjct: 1276 LTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ---QIEELKHQLEEETKAKNAL 1332
Query: 648 XXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI---KTHEKTAEIQN-RMIMRL 703
+ L EQ +E E R S+ + +T +T IQ +
Sbjct: 1333 AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1392
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
+K++ + + E +N E K+ V+DL E N D +
Sbjct: 1393 KKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNF 1452
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
++ S+ + + T +E+ D E + ++ +
Sbjct: 1453 DKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQ-- 1510
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDE-CETCAEYLQERDEQCARLKKEKLSL 882
E+S L E++ +++ +L++ K+++ E CE A L+E + + + L +
Sbjct: 1511 -----EISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA-LEEAEASLEHEEGKILRI 1564
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM--SYDAEVEKNKRLM 940
+ +++ +K ++ K A+ D+ N H+ VV+ M + DAE+ +
Sbjct: 1565 QLELNQVKSEV--------DRKIAEKDEEIDQLKRN-HTRVVETMQSTLDAEIRSRNDAL 1615
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
+ +++ + DL ++ A + + + + L++ + L++ + ++L E
Sbjct: 1616 RVKKKM---EGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKE 1672
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV--ALEK-QIESLSNTPVSNSTMY 1057
+ + + + L E K++ Q++ A E+ Q+ NT + N+
Sbjct: 1673 QLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1732
Query: 1058 VATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ + +Q+ ++ +V++E++ ++ K IT
Sbjct: 1733 LENDVSQLQS-EVEEVIQESRNAEEKAKKAIT 1763
Score = 52.0 bits (119), Expect = 1e-05
Identities = 66/311 (21%), Positives = 143/311 (45%), Gaps = 29/311 (9%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--------------AEYLQER 868
S ++ E++ +KE + EL + + KEL+++ T A+ L +
Sbjct: 845 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K+ LE ++ + E R ++ E A+ +++ + L + D
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTE--RAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 929 YDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQK----AMEKYTKKDKEFEAKRKELED 983
A+VEK K + ++ L + L T+ K+ K E + + + +A+ ++
Sbjct: 963 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI 1022
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA--KIALEIVDKLSNQKVALEK 1041
+L+Q+ +L+ E + L+ E+ KR E K+A E + N K L++
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081
Query: 1042 QIESLSNTPVSNSTMYVATGSAI-VQNQ-QITDVMKENQKL-KKMNAKLITICK-KRGKT 1097
++E +SN + A+ +Q Q +I ++ ++L +++ A+ + K ++ ++
Sbjct: 1082 KLEK-KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRS 1140
Query: 1098 GANRENEDPSD 1108
+RE E+ S+
Sbjct: 1141 DLSRELEEISE 1151
Score = 50.0 bits (114), Expect = 5e-05
Identities = 122/722 (16%), Positives = 280/722 (38%), Gaps = 51/722 (7%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM 117
KMC+SL++ +E+ K E+ + D+ Q++ L+ + + +D L+SQ+ +
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309
Query: 118 ENLTKDKEIKN-LTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD-DLKKNN 175
+ + +E+K+ L + K K+ + LQ +L+ E E E+ L K N
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHD-CDLLREQYEEEQEGKAELQRALSKAN 1368
Query: 176 ECLTQ--KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLH---IGYDNTLSKLNRSI 230
+ Q + + + E + K + + + E +++++ + T +L +
Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEV 1428
Query: 231 SDSNTST-RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN 289
D R N C + LD + + ++ ++ + E ++ +K E+
Sbjct: 1429 EDLMLDVERSNAAC---AALDKKQRNFDKVLSEWKQ-----KYEETQAELEASQK--ESR 1478
Query: 290 EFETKAVKVMSEIKRNLNSLSEQLINNES--KKSKDHIDRYKDSLLAVLDAEFGTTSLDV 347
T+ KV + + +L+ L N++ ++ D ++ + + + E ++
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ 1538
Query: 348 FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE-KENACN 406
+ + + + + L+ K ++Q +LN+ SE V+ K+A + ++ + K N
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSE---VDRKIAEKDEEIDQLKRNHTR 1595
Query: 407 ILRIQKERIH-EISSAVTIDIVKK--ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK 463
++ + + EI S VKK E +L E + + ++L + R+ K
Sbjct: 1596 VVETMQSTLDAEIRSRNDALRVKKKMEGDLNE-MEIQLNHANRLAAESLRNYRNTQGILK 1654
Query: 464 KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
+ + D + E + I + + L + + L +A
Sbjct: 1655 ETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASE 1714
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LT 582
V+ LH + T L +K K L ++ L+ + + ++ + EK K +T
Sbjct: 1715 RVQLLHTQNTSLINTK-----------KKLENDVSQLQSEVEEVIQESRNAEEKAKKAIT 1763
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ LK+E ++ L + + + E +L+ +Q + K + L
Sbjct: 1764 DAAMMAEELKKEQDTSAHL-ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL---- 1818
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E ++ ++N + + R L + K ++ +
Sbjct: 1819 -----EARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDK 1873
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
LQ +++ + E E + N +K+ L+ + + A + + VN+L + V +
Sbjct: 1874 LQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERAHIAESQVNKLRVKSREVHTK 1933
Query: 763 IA 764
I+
Sbjct: 1934 IS 1935
Score = 42.3 bits (95), Expect = 0.009
Identities = 70/396 (17%), Positives = 154/396 (38%), Gaps = 39/396 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR--DLLMSQIKSLEMENL 120
++ + E LE G++ I+ + + ++ + I E L + + +E
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQS 1602
Query: 121 TKDKEIKNLTDSLKTKSKK---INELQEENDTLSNLIME---NVTESDNLNKE----VDD 170
T D EI++ D+L+ K K +NE++ + + + L E N + + KE +DD
Sbjct: 1603 TLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDD 1662
Query: 171 LKKNNECLTQKCIDLEKLVN----------------ESENKIGPKNICAQCKLKENLIQS 214
+ E L ++ +E+ N E KI + + + + L+ +
Sbjct: 1663 ALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASE-RVQLLHT 1721
Query: 215 LHIGYDNTLSKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKN---H 269
+ NT KL +S S + + + D + E+ ++ H
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 270 LELHEPNMTM---DLDEKLGENNEFETKA-VKVMSEIKRNLNSLSEQLINNESKKSKDHI 325
LE + N+ DL +L E + K K + +++ + L + + NE K++ + +
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE-VENEQKRNAEAV 1840
Query: 326 DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELK 385
+ V + + T + + ++++K Q + + + + N S+ +
Sbjct: 1841 KGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900
Query: 386 SVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
+ +L + E+ N LR++ +H SA
Sbjct: 1901 KLQHELEEAEERAHIAESQVNKLRVKSREVHTKISA 1936
>AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related
protein protein.
Length = 1820
Score = 92.3 bits (219), Expect = 9e-18
Identities = 193/970 (19%), Positives = 391/970 (40%), Gaps = 82/970 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ SL+ + +K +K T S + + + E ++ + L N E+ L++++D
Sbjct: 499 SQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD 558
Query: 170 DLKKNNECLT-----QKCIDL-----EKLVNESENKIGPKNICAQCKLKENLIQSL---- 215
+ N+ +K +DL +KL+NE + K+ + K++E + Q
Sbjct: 559 KTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL-----TLEFKIREEVTQEFTQYW 613
Query: 216 ---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL 272
+ TL + R I + N R L + D E K++C T ++ E
Sbjct: 614 AQREADFKETLLQ-EREILEENAERRLAIFKDLVGKCDTREEAAKDICA--TKVETE-ET 669
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK--KSKDHIDRYKD 330
H D+ + L +N K ++ +L E E K + K + + K
Sbjct: 670 HNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKG 729
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L+ + L E D++I + + + +I+ + +++ +N + ++NE
Sbjct: 730 ELIKTKE------ELKKRENESDSLIQELKTSIKKIITQNQRIKELINIIDQKEDTINE- 782
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-EL-KEILTKECLKLSKLK 448
+L S L+E CN ++ S + ++ E E+ K+ +K C + ++
Sbjct: 783 FQNLKS-LMENTFKCN------DKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVN 835
Query: 449 IDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE---IEKEKLRLETGTAKAVXXXXX 505
+L QD P KK +I + IT+ + + E E +R+ + +
Sbjct: 836 ---ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 892
Query: 506 XXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIA 565
+ E + ++ +EL+ K + + + I L + +
Sbjct: 893 TIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKS 952
Query: 566 KNEEKMLSLSEKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
KN+E+ + + N++ T S N + + ++++ T + +Q S ++
Sbjct: 953 KNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDL 1012
Query: 625 QNGFELDKM---KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCS 680
NG E D + + D+L ++ ++ A+ E+C+E + S
Sbjct: 1013 SNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASS 1072
Query: 681 RLEINIKTHEKTAEIQNRMIM-------RL-QKQIQEDDKLFIEKETKLNELTNKYEALK 732
+ I+ E+ E + RL +K+ + D L EKET + +L + +
Sbjct: 1073 KKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKN 1132
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRT---EQTATVXXXXXXXXXXX 789
D ++ + + A+++LT + +I ELE+ + T E++ +
Sbjct: 1133 VTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVERSHSAKLEQDILEKES 1192
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
F + +D +N K D + + + E++QL L + L LKE
Sbjct: 1193 IILKLERNLKEFQEHLQDSVKNTK--DLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKE 1247
Query: 850 RYKELD-DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADV 908
+E + E E E L + LK + E+ ++LKE++ + +Q + +V
Sbjct: 1248 EEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEV 1306
Query: 909 AVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEK 966
+V DED L + ++ + + MK TI++L K+ L N K+++A+++
Sbjct: 1307 SVMRDED--KLLRIKINELEKKKNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQ 1359
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL 1026
Y + K+ K K +ED + LEE +Q E D+ E E +++ + ++ KE L
Sbjct: 1360 YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1419
Query: 1027 EIVDKLSNQK 1036
E + + K
Sbjct: 1420 ETKNNQRSNK 1429
Score = 83.0 bits (196), Expect = 5e-15
Identities = 219/1060 (20%), Positives = 448/1060 (42%), Gaps = 91/1060 (8%)
Query: 62 SLKESSNE--INLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQTRD--LLMSQIKSL 115
SL +SN +N+K +S E L D+ E + +E + +N ETQ + LL +
Sbjct: 503 SLDSNSNSKILNVKRATISWENSLEDLMEDEDLVE-ELENAE-ETQNVETKLLDEDLDKT 560
Query: 116 EMEN--LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDN---LNKEVD- 169
EN +E + L D ++ KK+ ++E TL I E VT+ +E D
Sbjct: 561 LEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADF 620
Query: 170 --DLKKNNECLTQ----KCIDLEKLVNESENK-IGPKNICAQCKLKENLIQSLHIGYDNT 222
L + E L + + + LV + + + K+ICA K++ + ++G+++
Sbjct: 621 KETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICA-TKVETEETHN-YVGFEDI 678
Query: 223 LSKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD 280
+ L +++D + I +L +A C EL F IK L + +
Sbjct: 679 IDSLQDNVADIKKQAEIAHLYIASLPDPQEA--TACLEL--KFNQIKAELAKTKGELIKT 734
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNL--NSLSEQLINNESKKSKDHIDRYKDSLLAVLDA 338
+E NE ++ ++ + IK+ + N ++LIN +K +D I+ ++ +L ++++
Sbjct: 735 KEELKKRENESDSLIQELKTSIKKIITQNQRIKELINIIDQK-EDTINEFQ-NLKSLMEN 792
Query: 339 EFG-TTSLDVFEILMDN--IINK-YQIDLD---EILEKYTKV-QGDL--NECTSELKSVN 388
F D ++++N I N+ ++ D +I + +V + +L +E ++ S++
Sbjct: 793 TFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIH 852
Query: 389 EKLASLNSQLIEKENACNILRIQKERI-HEISSAVTIDIVKKENELKEILTKECLKLSKL 447
A Q +E NI I+ R+ E + + ++ ENELK +E +L+K
Sbjct: 853 VSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKN-EKEEKAELNKQ 911
Query: 448 KIDIPRDLD----QDLPAHKKITIL---FDALITQYELSRTDYEIEKE---KLRLETGTA 497
+ ++L ++L K++ + +D I + + ++ + ++E KL E TA
Sbjct: 912 IVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETA 971
Query: 498 KAVXXXXXXXXXXXXXXFDTLE--EAHNEVKSLH-EELTKLYKSKVDEN--NANLNLI-- 550
D L ++ +++ ++ L L ++N N L+L+
Sbjct: 972 TRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGN 1031
Query: 551 -KILSEEIDALKIAIAKNEEKMLSLSEKD-NKLTELVSTINGLKEENNSLKSLNDVITRE 608
++S+++ +I E S E + E+V + + L+ + + E
Sbjct: 1032 DYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAE 1091
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
+ E R + +N +L K K ++ + + ++E AL
Sbjct: 1092 VKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV--QIQHVVEGKRAL 1149
Query: 669 KEQCEEKTRDCSRLEI-NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL-TN 726
E + T C + +I ++T +T +++ +L++ I E + + ++ E L E +
Sbjct: 1150 SELTQGVT--CYKAKIKELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEH 1207
Query: 727 KYEALKRDYDAAVKDL---ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXX 783
+++K D VK+L E + N L K L++ + E E++ + +
Sbjct: 1208 LQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS 1267
Query: 784 XXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE------VSQLKERL 837
+ D L + K ++ +SV+ D + +++L+++
Sbjct: 1268 SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKK 1327
Query: 838 LSCQQELDDLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
C QELD + ++L ++ + E +Q+ + C L ++ +E L+EQ +T
Sbjct: 1328 NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1387
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
Q VE Q + + + E A ++ + D E + N+R K E L N
Sbjct: 1388 Q--VE-QDQVLEAKLEEVERLATELEKWKEKCN-DLETKNNQRSNKEHENNTDVLGKLTN 1443
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
++Q++ +KY K++ ++ L E E + R KE+ + E + KQ+ E
Sbjct: 1444 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI--RNKEMKKYAEDRERFFKQQNEM 1501
Query: 1016 ---CKRLKEAKIALEIVDKLSNQKV-ALEKQIESLSNTPV 1051
+L E L+ + +Q V ALE Q+++L ++ V
Sbjct: 1502 EILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNV 1541
Score = 70.5 bits (165), Expect = 3e-11
Identities = 179/947 (18%), Positives = 379/947 (40%), Gaps = 71/947 (7%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEM 117
C LK N+I +L K GEL KE+ E + +LI L+T + ++ + E+
Sbjct: 712 CLELK--FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELKTSIKKIITQNQRIKEL 769
Query: 118 ENLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
N+ KE N +LK+ + + ++ DT S+LI+ N N EV K+
Sbjct: 770 INIIDQKEDTINEFQNLKSLMENTFKCNDKADT-SSLIINNKLIC-NETVEVPKDSKSKI 827
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
C +K ++ E + + E +I + E+ +S + + + R + ++N
Sbjct: 828 CSERKRVN-ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 886
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE-PNMTMDLDEKLGENNEFETKA 295
R + T+++EL +E+ EL + + L L E N+T+ + + ++N ++
Sbjct: 887 LR-AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN-YDIAI 944
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDN 354
++ ++++ N E+ I K + I+ S+ V + T +D L D+
Sbjct: 945 AEL--HVQKSKNQEQEEKI----MKLSNEIETATRSITNNVSQIKLMHTKIDELRTL-DS 997
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSV-NEKLAS--LNSQLIEKENACNILRIQ 411
+ IDL + + + D N ++L + N+ L S + I++ N N
Sbjct: 998 VSQISNIDLLNLRDLSNGSEED-NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1056
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
E I E + KK ++++E+ ++ KL+ ++ D++ +K D
Sbjct: 1057 IEAIWEECKEIVKASSKKSHQIEELEQ----QIEKLQAEVKGYKDENNRLKEKEHKNQDD 1112
Query: 472 LITQYE--LSRTDYEIEKEKLRLETG-----TAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
L+ + E + + E++++ + L+ K LE
Sbjct: 1113 LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 1172
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
K KL + +++ + L L + L E + L+ ++ KN + L+ K+ KL E
Sbjct: 1173 QKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV-KNTK---DLNVKELKLKEE 1228
Query: 585 VSTI-NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
++ + N L++ +K L + E+ET E E+ + + + +KAD+
Sbjct: 1229 ITQLTNNLQD----MKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1284
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
+ K + ++ ++++ + + LE + +++ R I +L
Sbjct: 1285 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1344
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
++Q+ K+ E +YE +D + K +E R + + Q + + ++
Sbjct: 1345 KEQLNNQ---------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQV 1394
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E + + E+ AT + LG+ L D + S
Sbjct: 1395 LEAKLE-EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQ 1453
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
+ L+E+++ Q + R KE+ +Y ++R+ R K++ +E
Sbjct: 1454 KYNADRKKWLEEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEME 1502
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ L E+ +++ + D V E L +++ + D E+E+ KR++
Sbjct: 1503 ILTAQLTEK---DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISET 1557
Query: 944 EELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ + D+K ++ + FE R ++ED L+
Sbjct: 1558 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 1604
Score = 41.1 bits (92), Expect = 0.021
Identities = 57/290 (19%), Positives = 131/290 (45%), Gaps = 17/290 (5%)
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
+N K + + V E+S +++ L+ +E+ ++ Y E QE++
Sbjct: 899 KNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQE 958
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLHSV----VV 924
E+ +L E + + ++N QI+ ++ V+ ++ D NL +
Sbjct: 959 EKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEE 1018
Query: 925 DRM-SYDAEVEKNKRLM-KTIEELRYKKQDLKNTV-TKMQKAMEKYTKKDKEFEAKRKEL 981
D + + ++ N L+ K ++E R ++ + +N+ + ++ E+ + K K ++
Sbjct: 1019 DNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQI 1078
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALE 1040
E+ + ++E+L+ K +E E K+ + Q LKE + + ++ ++L + V L+
Sbjct: 1079 EELEQQIEKLQAEVKGYKDENNRLKE--KEHKNQDDLLKEKETLIQQLKEELQEKNVTLD 1136
Query: 1041 KQIESL--SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM-NAKL 1087
QI+ + +S T V A ++ + + E QK+++ +AKL
Sbjct: 1137 VQIQHVVEGKRALSELTQGVTCYKAKIKE---LETILETQKVERSHSAKL 1183
Score = 36.3 bits (80), Expect = 0.61
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 1401 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 1458
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 1459 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1518
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 1519 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1572
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 1573 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEASTENDQ-STRFPKPELEIQ 1626
Score = 33.5 bits (73), Expect = 4.3
Identities = 60/298 (20%), Positives = 118/298 (39%), Gaps = 18/298 (6%)
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
LD + + + + IS E +L + + +++L + E+ ++L E + E QE + A
Sbjct: 557 LDKTLEENKAFISHEEKRKLLDLIEDLKKKL--INEKKEKLTLEFKIREEVTQEFTQYWA 614
Query: 874 RLKKE-KLSLEQQVSNLKEQIRTQQPVERQ-AKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ + + K +L Q+ L+E + + + D +D + +Y
Sbjct: 615 QREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVG 674
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL--- 988
+ L + +++ + + + + E + +F + EL K EL
Sbjct: 675 FEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKT 734
Query: 989 -EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLS 1047
EELK+R E D + +K+ Q +R+KE + I+D+ + + +
Sbjct: 735 KEELKKRENESDSLIQELKTSIKKIITQNQRIKE---LINIIDQKEDTINEFQNLKSLME 791
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENED 1105
NT N T S I+ N+ I + E K K IC +R + N +D
Sbjct: 792 NTFKCNDK--ADTSSLIINNKLICNETVEVPKDSKSK-----ICSERKRVNENELQQD 842
>M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein.
Length = 1976
Score = 91.5 bits (217), Expect = 2e-17
Identities = 168/888 (18%), Positives = 372/888 (41%), Gaps = 64/888 (7%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
+L++ E+ +E + + K ++ H ++ LDE+ G + + + V ++IK+
Sbjct: 926 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEE 985
Query: 308 S--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL----DVFEILMDNI---INK 358
L E + K+ K DR + + + E +L + E+++ ++ + K
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1045
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN--ILRIQKERIH 416
+ E+ + K+ G+ + ++ + ++ L QL +KE + R E +H
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105
Query: 417 EISS-AVTIDIVKKENELKEILTKECLKLSKLKID-IPRDLDQDLPAHK-KITILFDALI 473
+ ++ V ++ + EL+E E K S+ K + RDL ++L A K ++ D
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESE--KASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 474 TQYEL-SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL 532
Q EL ++ + E+ + K LE T K + L E + K L
Sbjct: 1164 AQQELRTKREQEVAELKKALEEET-KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 533 TKLYKSKVDENNANLNLIKILSE--------------EIDALKIAIAKNEEKMLSLSEKD 578
K + +N +K+L + ++ L +++ + + L+EK
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
+KL + ++ L EE K + ++ + S+L+ + +++++ + + + I
Sbjct: 1283 SKLQNELDNVSTLLEEAEK-KGIK--FAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ K+L +Q LAL+ Q + + +++ ++ T E E + +
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK---KVDDDLGTIESLEEAKKK 1396
Query: 699 MIM---RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLESSREAVNQL 752
++ L ++++E + + E N L + + L D D +LE ++ +QL
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++ + R AE E D R E A F +N+ L +
Sbjct: 1457 LAEEKSISARYAE-ERD-RAEAEAR-EKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--AEYLQERDE 870
+ S K + V +L++ + +Q++++++ + +EL+DE + A+ E +
Sbjct: 1514 EDLMSSKDDVG----KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 871 QCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
Q + + E+ L + + K+++ +Q E +A+ D A+ + +D
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 930 DAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKA---MEKYTKKDKEFEAKRKELE--- 982
+A++E NK + I++LR + +K+ ++++A ++ + KE E K K LE
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 983 -DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+ EL ++ + ++E + A+ + L + K LE +++ E+
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKL 1087
L N +T+ V T +A + ++ +N Q+L++ N +L
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Score = 87.4 bits (207), Expect = 2e-16
Identities = 165/848 (19%), Positives = 345/848 (40%), Gaps = 57/848 (6%)
Query: 263 FTSIKNHLELHEPNMTMDL-DEKLGENNEFETKAVKVMSEIKRN-------LNSLSEQL- 313
FT +K L++ + DE+L + E +TK + E++R N L+EQL
Sbjct: 838 FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897
Query: 314 ----INNESKKSKDHIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
+ E+++ + + K L +L D E + ++ N K Q + ++ E
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQ--LIEKENACNIL--RIQKERIHEISSAVTI 424
+ + +G + E + K+ + + L+E +N+ I ++ ++RI E SS +
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ K +N L +I K+ + +S L+ + ++ ++ +K D T + + +
Sbjct: 1018 EEEKAKN-LAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQDQIAELQ 1075
Query: 485 IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
+ ++L+L+ + + + E+++ EL + ++S+ N
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN-GLKEENNSLKSLND 603
+ LSEE++ALK + + + E K + V+ + L+EE + ++
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195
Query: 604 VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
+ + T EL + K+ L+K K + E++ +
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1255
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE 723
+ A ++ K + RL + + EK +++QN + D + T L E
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELA--EKASKLQNEL-----------DNV----STLLEE 1298
Query: 724 LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRT-EQTATVXXXX 782
K +D + L+ ++E + + T QK + RI +LE + + ++
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
T + DLG L+++ K+ ++ D+E L +RL
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK---LLKDAEA--LSQRLEEKAL 1413
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
D L++ L E + L + + + L+K++ +Q ++ K I + ER
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS-ISARYAEERD 1472
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQ 961
A+ A + +L + + + E E+ NK+L +E+L K D+ V +++
Sbjct: 1473 RAEAE-AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 962 KAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETCAEYLKQRE 1013
K+ ++ +E + +EL ED K LE Q K + + + +T E ++++
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 1014 E-QCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSAIVQNQQIT 1071
K+++E + LE K VA +K++E L + A I Q +++
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 1072 DVMKENQK 1079
MK+ Q+
Sbjct: 1652 AQMKDYQR 1659
Score = 81.4 bits (192), Expect = 2e-14
Identities = 192/1002 (19%), Positives = 400/1002 (39%), Gaps = 82/1002 (8%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSAL--EGKYQNLILETQTRDLLMSQIKSLEME 118
Q L+ K++K+ E+ +++Q S E K + + L + K+ +
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 119 NLTKDKE--IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
+ +E I +L + LK + K EL++ L + + L ++D+LK
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ-- 1084
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
L +K +L+ + +++ KN + ++E Q + D K +R+ ++
Sbjct: 1085 -LAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
++ L++EL ED D T+ + L +L + L E + +
Sbjct: 1143 DLSEELEALKTEL----EDTL----DTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 297 KVMSEIKRN-LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
+ M + L LSEQL ++K+ K ++++ K L + E + ++ ++
Sbjct: 1195 QDMRQRHATALEELSEQL--EQAKRFKANLEKNKQG-LETDNKELACEVKVLQQVKAESE 1251
Query: 356 INKYQIDLDEILEKYTKV-QGDLNECTSELKSVNEKLASLNSQLIEKENACNIL-RIQKE 413
+ ++D ++ E + KV +GD EL EK + L ++L +N +L +K+
Sbjct: 1252 HKRKKLDA-QVQELHAKVSEGD--RLRVELA---EKASKLQNEL---DNVSTLLEEAEKK 1302
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
I A +++ + + +E+L +E + L I R L+++ + ++
Sbjct: 1303 GIKFAKDAASLE--SQLQDTQELLQEETRQKLNLSSRI-RQLEEEKNSLQE--------- 1350
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
Q E +EK+ L L++ A ++LEEA ++ E L+
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLA-----DTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+ + K + L +E+D L + + + +L +K K +L++ +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ + REKET+A L R+ + + E ++ +
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E L + AL++Q EE LE ++ E A+++ + M+ K E D
Sbjct: 1526 NVHE---LEKSKRALEQQVEEMRTQLEELEDELQATE-DAKLRLEVNMQAMKAQFERD-- 1579
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L + +LE R+ K +E + +LE+ I
Sbjct: 1580 -LQTRDEQNE--EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
A D R+L E + + S S+ ++ L
Sbjct: 1637 NKA----------RDEVIKQLRKLQAQMKDYQREL-EEARASRDEIFAQSKESEKKLKSL 1685
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ +L Q+EL + + + E + A+ + + L EK LE +++ L+E++
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745
Query: 894 RTQQP-VE-RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQ 951
+Q +E +F + D A L +R + ++L + +EL+ K Q
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAEL---AAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 952 DLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDC----KAELEELKQRYKELDEEC 1002
+L+ V KA K + +++ E + KE + ++LK+ + ++++E
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862
Query: 1003 ETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+Y +Q E+ R+K+ K LE ++ + + A ++++
Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Score = 53.2 bits (122), Expect = 5e-06
Identities = 174/899 (19%), Positives = 351/899 (39%), Gaps = 80/899 (8%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL--QDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
+L GA ++ D+ ++N +K+ + I + +S K S N+ + LS EL
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 84 IK-EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+K E + L+ L T+ + K+LE E TK+ E + + D + + + E
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--TKNHEAQ-IQDMRQRHATALEE 1207
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L E+ + NL K L+ +N+ L + L+++ ESE+K K +
Sbjct: 1208 LSEQLEQAKRF-------KANLEKNKQGLETDNKELACEVKVLQQVKAESEHK--RKKLD 1258
Query: 203 AQCK---LKENLIQSLHIGYDNTLSKLNRSISDSNT-----STRYNKICTLQSELDAGRE 254
AQ + K + L + SKL + + +T + K + L++ +
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 255 DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLI 314
D +EL ++ T K +L + L+E+ E + + + +++ + +L QL
Sbjct: 1319 DTQELLQEETRQKLNLS----SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 315 NNESKKSKD--HIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNII---NKYQIDLDEI-- 366
+ + K D I+ +++ +L DAE + L+ + D + N+ Q +LD++
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEISSAVTI 424
L+ +V +L + + + + S++++ E+ + +KE + ++ A+
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 425 DIVKKEN--ELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
+ KE + L + L K D+ +++ +L K+ AL Q E RT
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV-HELEKSKR------ALEQQVEEMRTQ 1547
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
E +++L+ + T +E + E K L L K +V E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL------LIK-QVRE 1600
Query: 543 NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLN 602
A L E + + A+A +K + + KD L + N ++E +K L
Sbjct: 1601 LEAEL--------EDERKQRALAVASKKKMEIDLKD--LEAQIEAANKARDE--VIKQLR 1648
Query: 603 DVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ + K+ Q ELE + + + F K L + A+
Sbjct: 1649 KLQAQMKDYQR-ELEEA-RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 663 EQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
EQ E +E T S + ++ ++ R I +L+++++E+ +
Sbjct: 1707 EQER--DELADEITNSASGKSALL---DEKRRLEAR-IAQLEEELEEEQSNMELLNDRFR 1760
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
+ T + + L + A + S A QL Q ++ ++ ELE ++++ AT+
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSC 840
N+ + K K + D Q KE++
Sbjct: 1821 AKIGQLEEQLEQEAKERAAA--NKLVRRTEK---KLKEIFMQVEDERRHADQYKEQMEKA 1875
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ LK + +E ++E ++ + + L ++VS LK ++R P+
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934
>M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy chain
protein.
Length = 1937
Score = 91.5 bits (217), Expect = 2e-17
Identities = 198/1097 (18%), Positives = 458/1097 (41%), Gaps = 96/1097 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K KND ++ QS L D+ + C+ L ++ ++ K+++++ + +E +
Sbjct: 885 KEKNDLQLQVQSEADSLADAE------ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE 938
Query: 91 LEGKYQNLI-----LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
L K + L L+ DL ++ K + ++ T++K +KNLT+ + + I +L +
Sbjct: 939 LTAKKRKLEDECSELKKDIDDLELTLAKVEKQKHATENK-VKNLTEEMAGLDETIAKLSK 997
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQC 205
E L + + + +V+ L K L Q+ DLE + E E K+ A+
Sbjct: 998 EKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL-EQEKKLRMDLERAKR 1056
Query: 206 KLKENLIQSLHIGYDNTLSKLN-RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
KL+ + L + ++T+ N + D + +I L S+++ + +L +
Sbjct: 1057 KLEGD----LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIK 1112
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN-NESKKSKD 323
++ +E +L E++ KA K S++ R L +SE+L + ++
Sbjct: 1113 ELQARIE--------ELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV 1164
Query: 324 HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY---QIDLDEILEKYTKVQGDLNEC 380
+++ +++ L + +L E ++ + K+ +L E ++ +V+ L +
Sbjct: 1165 ELNKKREAEFQKLRRDLEEATLQ-HEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKE 1223
Query: 381 TSELKSVNEKLASLNSQLIEK-----ENACNI-------LRIQKERIHEISSAVTIDIVK 428
SELK + L+S N++ I K E C L+ ++E + + +T +
Sbjct: 1224 KSELKMETDDLSS-NAEAISKAKGHLEKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRAR 1282
Query: 429 KENEL----KEILTKECL--KLSKLK-------IDIPRDLDQDLPAHKKITILFDALITQ 475
+ E +++ ++ L +LS+ K ++ L+++ A + +
Sbjct: 1283 LQTEAGEYSRQLDEQDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342
Query: 476 YELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
+L R YE E+E K L+ +KA EE K L + L +
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1402
Query: 535 L--YKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
+ V+ A+L K L E++ L + + ++ +L +K +++S
Sbjct: 1403 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSE---W 1459
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
K++ ++ + +E + ++EL + V +++ LD+++
Sbjct: 1460 KQKYEETQAELEASQKESRSLSTELFKVKNVYEES---LDQLETLRRAHKNLQQEISDLT 1516
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+ K + E +K+Q E++ C ++ ++ E + E + I+R+Q ++ +
Sbjct: 1517 EQIAEGGKQIHELE-KIKKQVEQE--KC-EIQAALEEAEASLEHEEGKILRIQLEL---N 1569
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
++ E + K+ E + + LKR++ V+ ++S+ +A ++ ++ D + + ++E D+
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA--EIRSRNDALRVK-KKMEGDLN 1626
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
+ + + L + + + K ++++ + +
Sbjct: 1627 EME---IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIV-ERRAN 1682
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
L+ + L+ + K + E +E +Q Q L K LE VS L+
Sbjct: 1683 LLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQS 1742
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKK 950
++ ++ ++ + A D A + + A +E+ K L +T+++L+++
Sbjct: 1743 EV--EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1800
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYL 1009
+ + Q A++ K+ ++ EA+ +ELE + + E + + K L + E
Sbjct: 1801 DEAE------QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHDRRVKELT 1854
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
Q EE K + + ++VDKL + + ++Q E +N + + + + ++
Sbjct: 1855 YQTEEDRKNVLRLQ---DLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Query: 1070 ITDVMKENQKLKKMNAK 1086
D+ + ++ K+ K
Sbjct: 1912 RADIAE--SQVNKLRVK 1926
Score = 77.0 bits (181), Expect = 4e-13
Identities = 105/529 (19%), Positives = 217/529 (41%), Gaps = 37/529 (6%)
Query: 555 EEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
+E+ +K K ++++ K +L E + T+ LKE+N+ L + E ++ A
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTL--LKEKND----LQLQVQSEADSLAD 903
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
ER Q+IK N +L+ ++ + L + L+++C E
Sbjct: 904 AEERCEQLIK-NKIQLEAKIKEV----------TERAEEEEEINAELTAKKRKLEDECSE 952
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
+D LE+ + EK + L +++ D ET + +L+ + +AL+
Sbjct: 953 LKKDIDDLELTLAKVEKQKHATENKVKNLTEEMAGLD------ET-IAKLSKEKKALQET 1005
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ + DL++ + VN LT K +E ++ +LE + E+ +
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1065
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
++ + L E KL+ ++IS E Q E + Q+++ +L+ R +EL
Sbjct: 1066 QESTMDMENDKQQLDE--KLEKKEFEISNLISKIEDEQAVE--IQLQKKIKELQARIEEL 1121
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKFADVAVNT 912
+E E + ++Q + L +E + +++ Q + +R+A+F + +
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL 1181
Query: 913 DEDWANLHSVVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
+E ++V A+ E+ L + ++L +K +LK + E
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
+K E + LED + L+ ++ + L + L+ + R + + AL
Sbjct: 1242 SKAKGHLEKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEQDAL- 1300
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
V +LS K A +QIE L + + A A+ ++ D+++E
Sbjct: 1301 -VSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE 1348
Score = 63.7 bits (148), Expect = 4e-09
Identities = 176/887 (19%), Positives = 338/887 (38%), Gaps = 86/887 (9%)
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV---MSE 301
+QSE D+ D +E CE K LE +T +E+ N E K K+ SE
Sbjct: 894 VQSEADS-LADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE 952
Query: 302 IKRNLNSLSEQLINNESKK--SKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+K++++ L L E +K +++ + + + A LD S + + L + +
Sbjct: 953 LKKDIDDLELTLAKVEKQKHATENKVKNLTEEM-AGLDETIAKLSKEK-KALQET----H 1006
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH--- 416
Q LD++ + KV N T + +++ L L +++ L K ++
Sbjct: 1007 QQTLDDLQAEEDKV----NILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+++ T+D+ + +L E L K+ ++S L I + ++ KKI L Q
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKEL------QA 1116
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+ EIE E+ AKA + LEEA S EL K
Sbjct: 1117 RIEELGEEIEAER----ASRAKAEKQRSDLSRELEEIS-ERLEEAGGAT-SAQVELNKKR 1170
Query: 537 KSKVDENNANLNLIKILSEE-IDALKIAIAKNEEKMLSLSEKDNKLTELVSTI----NGL 591
+++ + +L + E + AL+ K+ + M L E+ + L + + + L
Sbjct: 1171 EAEFQKLRRDLEEATLQHEAMVAALR---KKHADSMAELGEQIDNLQRVKQKLEKEKSEL 1227
Query: 592 KEENNSLKSLNDVITREK---ETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXX 648
K E + L S + I++ K E LE +K E ++ D+
Sbjct: 1228 KMETDDLSSNAEAISKAKGHLEKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEA 1287
Query: 649 XXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ 708
DE +L+ Q L + T+ L+ + E+ + +N + LQ
Sbjct: 1288 GEYSRQLDEQDALVSQ---LSRSKQASTQQIEELKHQL---EEETKAKNALAHALQSSRH 1341
Query: 709 EDDKLFIEKETKLNELTNKYEAL-KRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
+ D L + E + AL K + + A + +A+ Q T + + + ++A+
Sbjct: 1342 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI-QRTEELEEAKKKLAQRL 1400
Query: 768 SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+ E+ D R LD + D
Sbjct: 1401 QE--AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNF-----D 1453
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+S+ K++ Q EL+ ++ + L E +E +Q L++ +L+Q++S
Sbjct: 1454 KVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRAHKNLQQEIS 1513
Query: 888 NLKEQIR----------------TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+L EQI Q+ E QA + + + + + + ++ +
Sbjct: 1514 DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKS 1573
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
EV+ +++ + EE+ K++ V MQ ++ + + +K++E +L E+
Sbjct: 1574 EVD--RKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME---GDLNEM 1628
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQIESL- 1046
+ +L+ AE L+ LKE ++ AL + L Q +E++ L
Sbjct: 1629 E---IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685
Query: 1047 SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ +T+ S + Q++ D + Q L N LI KK
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1732
Score = 57.2 bits (132), Expect = 3e-07
Identities = 79/412 (19%), Positives = 179/412 (43%), Gaps = 23/412 (5%)
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVK 740
+L IK K+AE + M ++++ Q+ + E K EL K L ++ +
Sbjct: 834 KLFFKIKPLLKSAETEKEMAT-MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQL 892
Query: 741 DLESSREAVNQLTTQ-KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
++S +++ + + L++ +I +LE+ I+ T
Sbjct: 893 QVQSEADSLADAEERCEQLIKNKI-QLEAKIKE---VTERAEEEEEINAELTAKKRKLED 948
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
+ +D+ ++ +L + ++++V L E + + + L + K L + +
Sbjct: 949 ECSELKKDI-DDLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 1007
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
+ LQ +++ L K K LEQQV +L+ + ++ + + A + D A
Sbjct: 1008 QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ--KAME-KYTKKDKEFEA 976
++ ++E +K+ + E+L K+ ++ N ++K++ +A+E + KK KE +A
Sbjct: 1068 STM---------DMENDKQQLD--EKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQA 1116
Query: 977 KRKEL-EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQ 1035
+ +EL E+ +AE + K+ + E + +R E+ A++ L + Q
Sbjct: 1117 RIEELGEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQVELNKKREAEFQ 1175
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
K+ + + +L + + + S +QI ++ + QKL+K ++L
Sbjct: 1176 KLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSEL 1227
Score = 52.0 bits (119), Expect = 1e-05
Identities = 66/311 (21%), Positives = 143/311 (45%), Gaps = 29/311 (9%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--------------AEYLQER 868
S ++ E++ +KE + EL + + KEL+++ T A+ L +
Sbjct: 845 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K+ LE ++ + E R ++ E A+ +++ + L + D
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTE--RAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 929 YDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQK----AMEKYTKKDKEFEAKRKELED 983
A+VEK K + ++ L + L T+ K+ K E + + + +A+ ++
Sbjct: 963 TLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI 1022
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA--KIALEIVDKLSNQKVALEK 1041
+L+Q+ +L+ E + L+ E+ KR E K+A E + N K L++
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081
Query: 1042 QIESLSNTPVSNSTMYVATGSAI-VQNQ-QITDVMKENQKL-KKMNAKLITICK-KRGKT 1097
++E +SN + A+ +Q Q +I ++ ++L +++ A+ + K ++ ++
Sbjct: 1082 KLEK-KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRS 1140
Query: 1098 GANRENEDPSD 1108
+RE E+ S+
Sbjct: 1141 DLSRELEEISE 1151
Score = 41.9 bits (94), Expect = 0.012
Identities = 70/396 (17%), Positives = 154/396 (38%), Gaps = 39/396 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR--DLLMSQIKSLEMENL 120
++ + E LE G++ I+ + + ++ + I E L + + +E
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQS 1602
Query: 121 TKDKEIKNLTDSLKTKSKK---INELQEENDTLSNLIME---NVTESDNLNKE----VDD 170
T D EI++ D+L+ K K +NE++ + + + L E N + + KE +DD
Sbjct: 1603 TLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDD 1662
Query: 171 LKKNNECLTQKCIDLEKLVN----------------ESENKIGPKNICAQCKLKENLIQS 214
+ E L ++ +E+ N E KI + + + + L+ +
Sbjct: 1663 ALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASE-RVQLLHT 1721
Query: 215 LHIGYDNTLSKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKN---H 269
+ NT KL +S S + + + D + E+ ++ H
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 270 LELHEPNMTM---DLDEKLGENNEFETKA-VKVMSEIKRNLNSLSEQLINNESKKSKDHI 325
LE + N+ DL +L E + K K + +++ + L + + NE K++ + +
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE-VENEQKRNAEAV 1840
Query: 326 DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELK 385
+ V + + T + + ++++K Q + + + + N S+ +
Sbjct: 1841 KGLRKHDRRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900
Query: 386 SVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
+ +L + E+ N LR++ +H SA
Sbjct: 1901 KLQHELEEAEERADIAESQVNKLRVKSREVHTKISA 1936
>BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 91.5 bits (217), Expect = 2e-17
Identities = 168/888 (18%), Positives = 372/888 (41%), Gaps = 64/888 (7%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
+L++ E+ +E + + K ++ H ++ LDE+ G + + + V ++IK+
Sbjct: 926 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEE 985
Query: 308 S--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL----DVFEILMDNI---INK 358
L E + K+ K DR + + + E +L + E+++ ++ + K
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1045
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN--ILRIQKERIH 416
+ E+ + K+ G+ + ++ + ++ L QL +KE + R E +H
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105
Query: 417 EISS-AVTIDIVKKENELKEILTKECLKLSKLKID-IPRDLDQDLPAHK-KITILFDALI 473
+ ++ V ++ + EL+E E K S+ K + RDL ++L A K ++ D
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESE--KASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 474 TQYEL-SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL 532
Q EL ++ + E+ + K LE T K + L E + K L
Sbjct: 1164 AQQELRTKREQEVAELKKALEEET-KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 533 TKLYKSKVDENNANLNLIKILSE--------------EIDALKIAIAKNEEKMLSLSEKD 578
K + +N +K+L + ++ L +++ + + L+EK
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
+KL + ++ L EE K + ++ + S+L+ + +++++ + + + I
Sbjct: 1283 SKLQNELDNVSTLLEEAEK-KGIK--FAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ K+L +Q LAL+ Q + + +++ ++ T E E + +
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK---KVDDDLGTIESLEEAKKK 1396
Query: 699 MIM---RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLESSREAVNQL 752
++ L ++++E + + E N L + + L D D +LE ++ +QL
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++ + R AE E D R E A F +N+ L +
Sbjct: 1457 LAEEKSISARYAE-ERD-RAEAEAR-EKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--AEYLQERDE 870
+ S K + V +L++ + +Q++++++ + +EL+DE + A+ E +
Sbjct: 1514 EDLMSSKDDVG----KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 871 QCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
Q + + E+ L + + K+++ +Q E +A+ D A+ + +D
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 930 DAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKA---MEKYTKKDKEFEAKRKELE--- 982
+A++E NK + I++LR + +K+ ++++A ++ + KE E K K LE
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 983 -DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+ EL ++ + ++E + A+ + L + K LE +++ E+
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKL 1087
L N +T+ V T +A + ++ +N Q+L++ N +L
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Score = 87.4 bits (207), Expect = 2e-16
Identities = 165/848 (19%), Positives = 345/848 (40%), Gaps = 57/848 (6%)
Query: 263 FTSIKNHLELHEPNMTMDL-DEKLGENNEFETKAVKVMSEIKRN-------LNSLSEQL- 313
FT +K L++ + DE+L + E +TK + E++R N L+EQL
Sbjct: 838 FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897
Query: 314 ----INNESKKSKDHIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
+ E+++ + + K L +L D E + ++ N K Q + ++ E
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQ--LIEKENACNIL--RIQKERIHEISSAVTI 424
+ + +G + E + K+ + + L+E +N+ I ++ ++RI E SS +
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ K +N L +I K+ + +S L+ + ++ ++ +K D T + + +
Sbjct: 1018 EEEKAKN-LAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQDQIAELQ 1075
Query: 485 IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
+ ++L+L+ + + + E+++ EL + ++S+ N
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN-GLKEENNSLKSLND 603
+ LSEE++ALK + + + E K + V+ + L+EE + ++
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195
Query: 604 VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
+ + T EL + K+ L+K K + E++ +
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1255
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE 723
+ A ++ K + RL + + EK +++QN + D + T L E
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELA--EKASKLQNEL-----------DNV----STLLEE 1298
Query: 724 LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRT-EQTATVXXXX 782
K +D + L+ ++E + + T QK + RI +LE + + ++
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
T + DLG L+++ K+ ++ D+E L +RL
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK---LLKDAEA--LSQRLEEKAL 1413
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
D L++ L E + L + + + L+K++ +Q ++ K I + ER
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS-ISARYAEERD 1472
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQ 961
A+ A + +L + + + E E+ NK+L +E+L K D+ V +++
Sbjct: 1473 RAEAE-AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 962 KAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETCAEYLKQRE 1013
K+ ++ +E + +EL ED K LE Q K + + + +T E ++++
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 1014 E-QCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSAIVQNQQIT 1071
K+++E + LE K VA +K++E L + A I Q +++
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 1072 DVMKENQK 1079
MK+ Q+
Sbjct: 1652 AQMKDYQR 1659
Score = 81.4 bits (192), Expect = 2e-14
Identities = 192/1002 (19%), Positives = 400/1002 (39%), Gaps = 82/1002 (8%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSAL--EGKYQNLILETQTRDLLMSQIKSLEME 118
Q L+ K++K+ E+ +++Q S E K + + L + K+ +
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 119 NLTKDKE--IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
+ +E I +L + LK + K EL++ L + + L ++D+LK
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ-- 1084
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
L +K +L+ + +++ KN + ++E Q + D K +R+ ++
Sbjct: 1085 -LAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
++ L++EL ED D T+ + L +L + L E + +
Sbjct: 1143 DLSEELEALKTEL----EDTL----DTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 297 KVMSEIKRN-LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
+ M + L LSEQL ++K+ K ++++ K L + E + ++ ++
Sbjct: 1195 QDMRQRHATALEELSEQL--EQAKRFKANLEKNKQG-LETDNKELACEVKVLQQVKAESE 1251
Query: 356 INKYQIDLDEILEKYTKV-QGDLNECTSELKSVNEKLASLNSQLIEKENACNIL-RIQKE 413
+ ++D ++ E + KV +GD EL EK + L ++L +N +L +K+
Sbjct: 1252 HKRKKLDA-QVQELHAKVSEGD--RLRVELA---EKASKLQNEL---DNVSTLLEEAEKK 1302
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
I A +++ + + +E+L +E + L I R L+++ + ++
Sbjct: 1303 GIKFAKDAASLE--SQLQDTQELLQEETRQKLNLSSRI-RQLEEEKNSLQE--------- 1350
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
Q E +EK+ L L++ A ++LEEA ++ E L+
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLA-----DTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+ + K + L +E+D L + + + +L +K K +L++ +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ + REKET+A L R+ + + E ++ +
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E L + AL++Q EE LE ++ E A+++ + M+ K E D
Sbjct: 1526 NVHE---LEKSKRALEQQVEEMRTQLEELEDELQATE-DAKLRLEVNMQAMKAQFERD-- 1579
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L + +LE R+ K +E + +LE+ I
Sbjct: 1580 -LQTRDEQNE--EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
A D R+L E + + S S+ ++ L
Sbjct: 1637 NKA----------RDEVIKQLRKLQAQMKDYQREL-EEARASRDEIFAQSKESEKKLKSL 1685
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ +L Q+EL + + + E + A+ + + L EK LE +++ L+E++
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745
Query: 894 RTQQP-VE-RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQ 951
+Q +E +F + D A L +R + ++L + +EL+ K Q
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAEL---AAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 952 DLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDC----KAELEELKQRYKELDEEC 1002
+L+ V KA K + +++ E + KE + ++LK+ + ++++E
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862
Query: 1003 ETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+Y +Q E+ R+K+ K LE ++ + + A ++++
Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Score = 53.2 bits (122), Expect = 5e-06
Identities = 174/899 (19%), Positives = 351/899 (39%), Gaps = 80/899 (8%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL--QDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
+L GA ++ D+ ++N +K+ + I + +S K S N+ + LS EL
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 84 IK-EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+K E + L+ L T+ + K+LE E TK+ E + + D + + + E
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--TKNHEAQ-IQDMRQRHATALEE 1207
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L E+ + NL K L+ +N+ L + L+++ ESE+K K +
Sbjct: 1208 LSEQLEQAKRF-------KANLEKNKQGLETDNKELACEVKVLQQVKAESEHK--RKKLD 1258
Query: 203 AQCK---LKENLIQSLHIGYDNTLSKLNRSISDSNT-----STRYNKICTLQSELDAGRE 254
AQ + K + L + SKL + + +T + K + L++ +
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 255 DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLI 314
D +EL ++ T K +L + L+E+ E + + + +++ + +L QL
Sbjct: 1319 DTQELLQEETRQKLNLS----SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 315 NNESKKSKD--HIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNII---NKYQIDLDEI-- 366
+ + K D I+ +++ +L DAE + L+ + D + N+ Q +LD++
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEISSAVTI 424
L+ +V +L + + + + S++++ E+ + +KE + ++ A+
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 425 DIVKKEN--ELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
+ KE + L + L K D+ +++ +L K+ AL Q E RT
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV-HELEKSKR------ALEQQVEEMRTQ 1547
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
E +++L+ + T +E + E K L L K +V E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL------LIK-QVRE 1600
Query: 543 NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLN 602
A L E + + A+A +K + + KD L + N ++E +K L
Sbjct: 1601 LEAEL--------EDERKQRALAVASKKKMEIDLKD--LEAQIEAANKARDE--VIKQLR 1648
Query: 603 DVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ + K+ Q ELE + + + F K L + A+
Sbjct: 1649 KLQAQMKDYQR-ELEEA-RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 663 EQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
EQ E +E T S + ++ ++ R I +L+++++E+ +
Sbjct: 1707 EQER--DELADEITNSASGKSALL---DEKRRLEAR-IAQLEEELEEEQSNMELLNDRFR 1760
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
+ T + + L + A + S A QL Q ++ ++ ELE ++++ AT+
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSC 840
N+ + K K + D Q KE++
Sbjct: 1821 AKIGQLEEQLEQEAKERAAA--NKLVRRTEK---KLKEIFMQVEDERRHADQYKEQMEKA 1875
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ LK + +E ++E ++ + + L ++VS LK ++R P+
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934
>AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein
protein.
Length = 2018
Score = 91.5 bits (217), Expect = 2e-17
Identities = 168/888 (18%), Positives = 372/888 (41%), Gaps = 64/888 (7%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
+L++ E+ +E + + K ++ H ++ LDE+ G + + + V ++IK+
Sbjct: 968 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEE 1027
Query: 308 S--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL----DVFEILMDNI---INK 358
L E + K+ K DR + + + E +L + E+++ ++ + K
Sbjct: 1028 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1087
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN--ILRIQKERIH 416
+ E+ + K+ G+ + ++ + ++ L QL +KE + R E +H
Sbjct: 1088 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1147
Query: 417 EISS-AVTIDIVKKENELKEILTKECLKLSKLKID-IPRDLDQDLPAHK-KITILFDALI 473
+ ++ V ++ + EL+E E K S+ K + RDL ++L A K ++ D
Sbjct: 1148 KNNALKVVRELQAQIAELQEDFESE--KASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1205
Query: 474 TQYEL-SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL 532
Q EL ++ + E+ + K LE T K + L E + K L
Sbjct: 1206 AQQELRTKREQEVAELKKALEEET-KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1264
Query: 533 TKLYKSKVDENNANLNLIKILSE--------------EIDALKIAIAKNEEKMLSLSEKD 578
K + +N +K+L + ++ L +++ + + L+EK
Sbjct: 1265 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1324
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
+KL + ++ L EE K + ++ + S+L+ + +++++ + + + I
Sbjct: 1325 SKLQNELDNVSTLLEEAEK-KGIK--FAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1381
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ K+L +Q LAL+ Q + + +++ ++ T E E + +
Sbjct: 1382 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK---KVDDDLGTIESLEEAKKK 1438
Query: 699 MIM---RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLESSREAVNQL 752
++ L ++++E + + E N L + + L D D +LE ++ +QL
Sbjct: 1439 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1498
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++ + R AE E D R E A F +N+ L +
Sbjct: 1499 LAEEKSISARYAE-ERD-RAEAEAR-EKETKALSLARALEEALEAKEEFERQNKQLRADM 1555
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--AEYLQERDE 870
+ S K + V +L++ + +Q++++++ + +EL+DE + A+ E +
Sbjct: 1556 EDLMSSKDDVG----KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1611
Query: 871 QCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
Q + + E+ L + + K+++ +Q E +A+ D A+ + +D
Sbjct: 1612 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1671
Query: 930 DAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKA---MEKYTKKDKEFEAKRKELE--- 982
+A++E NK + I++LR + +K+ ++++A ++ + KE E K K LE
Sbjct: 1672 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1731
Query: 983 -DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+ EL ++ + ++E + A+ + L + K LE +++ E+
Sbjct: 1732 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1791
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKL 1087
L N +T+ V T +A + ++ +N Q+L++ N +L
Sbjct: 1792 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1839
Score = 87.4 bits (207), Expect = 2e-16
Identities = 165/848 (19%), Positives = 345/848 (40%), Gaps = 57/848 (6%)
Query: 263 FTSIKNHLELHEPNMTMDL-DEKLGENNEFETKAVKVMSEIKRN-------LNSLSEQL- 313
FT +K L++ + DE+L + E +TK + E++R N L+EQL
Sbjct: 880 FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 939
Query: 314 ----INNESKKSKDHIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
+ E+++ + + K L +L D E + ++ N K Q + ++ E
Sbjct: 940 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 999
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQ--LIEKENACNIL--RIQKERIHEISSAVTI 424
+ + +G + E + K+ + + L+E +N+ I ++ ++RI E SS +
Sbjct: 1000 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1059
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ K +N L +I K+ + +S L+ + ++ ++ +K D T + + +
Sbjct: 1060 EEEKAKN-LAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQDQIAELQ 1117
Query: 485 IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
+ ++L+L+ + + + E+++ EL + ++S+ N
Sbjct: 1118 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1177
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN-GLKEENNSLKSLND 603
+ LSEE++ALK + + + E K + V+ + L+EE + ++
Sbjct: 1178 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1237
Query: 604 VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
+ + T EL + K+ L+K K + E++ +
Sbjct: 1238 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1297
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE 723
+ A ++ K + RL + + EK +++QN + D + T L E
Sbjct: 1298 KLDAQVQELHAKVSEGDRLRVELA--EKASKLQNEL-----------DNV----STLLEE 1340
Query: 724 LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRT-EQTATVXXXX 782
K +D + L+ ++E + + T QK + RI +LE + + ++
Sbjct: 1341 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1400
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
T + DLG L+++ K+ ++ D+E L +RL
Sbjct: 1401 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK---LLKDAEA--LSQRLEEKAL 1455
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
D L++ L E + L + + + L+K++ +Q ++ K I + ER
Sbjct: 1456 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS-ISARYAEERD 1514
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQ 961
A+ A + +L + + + E E+ NK+L +E+L K D+ V +++
Sbjct: 1515 RAEAE-AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1573
Query: 962 KAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETCAEYLKQRE 1013
K+ ++ +E + +EL ED K LE Q K + + + +T E ++++
Sbjct: 1574 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1633
Query: 1014 E-QCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSAIVQNQQIT 1071
K+++E + LE K VA +K++E L + A I Q +++
Sbjct: 1634 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1693
Query: 1072 DVMKENQK 1079
MK+ Q+
Sbjct: 1694 AQMKDYQR 1701
Score = 81.4 bits (192), Expect = 2e-14
Identities = 192/1002 (19%), Positives = 400/1002 (39%), Gaps = 82/1002 (8%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSAL--EGKYQNLILETQTRDLLMSQIKSLEME 118
Q L+ K++K+ E+ +++Q S E K + + L + K+ +
Sbjct: 1009 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1068
Query: 119 NLTKDKE--IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
+ +E I +L + LK + K EL++ L + + L ++D+LK
Sbjct: 1069 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ-- 1126
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
L +K +L+ + +++ KN + ++E Q + D K +R+ ++
Sbjct: 1127 -LAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAELQEDFESEKASRNKAEKQKR 1184
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
++ L++EL ED D T+ + L +L + L E + +
Sbjct: 1185 DLSEELEALKTEL----EDTL----DTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1236
Query: 297 KVMSEIKRN-LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
+ M + L LSEQL ++K+ K ++++ K L + E + ++ ++
Sbjct: 1237 QDMRQRHATALEELSEQL--EQAKRFKANLEKNKQG-LETDNKELACEVKVLQQVKAESE 1293
Query: 356 INKYQIDLDEILEKYTKV-QGDLNECTSELKSVNEKLASLNSQLIEKENACNIL-RIQKE 413
+ ++D ++ E + KV +GD EL EK + L ++L +N +L +K+
Sbjct: 1294 HKRKKLDA-QVQELHAKVSEGD--RLRVELA---EKASKLQNEL---DNVSTLLEEAEKK 1344
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
I A +++ + + +E+L +E + L I R L+++ + ++
Sbjct: 1345 GIKFAKDAASLE--SQLQDTQELLQEETRQKLNLSSRI-RQLEEEKNSLQE--------- 1392
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
Q E +EK+ L L++ A ++LEEA ++ E L+
Sbjct: 1393 QQEEEEEARKNLEKQVLALQSQLA-----DTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1447
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+ + K + L +E+D L + + + +L +K K +L++ +
Sbjct: 1448 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1507
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ + REKET+A L R+ + + E ++ +
Sbjct: 1508 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1567
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E L + AL++Q EE LE ++ E A+++ + M+ K E D
Sbjct: 1568 NVHE---LEKSKRALEQQVEEMRTQLEELEDELQATE-DAKLRLEVNMQAMKAQFERD-- 1621
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
++ + NE K L + +LE R+ K +E + +LE+ I
Sbjct: 1622 -LQTRDEQNE--EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1678
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
A D R+L E + + S S+ ++ L
Sbjct: 1679 NKA----------RDEVIKQLRKLQAQMKDYQREL-EEARASRDEIFAQSKESEKKLKSL 1727
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ +L Q+EL + + + E + A+ + + L EK LE +++ L+E++
Sbjct: 1728 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1787
Query: 894 RTQQP-VE-RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQ 951
+Q +E +F + D A L +R + ++L + +EL+ K Q
Sbjct: 1788 EEEQSNMELLNDRFRKTTLQVDTLNAEL---AAERSAAQKSDNARQQLERQNKELKAKLQ 1844
Query: 952 DLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDC----KAELEELKQRYKELDEEC 1002
+L+ V KA K + +++ E + KE + ++LK+ + ++++E
Sbjct: 1845 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1904
Query: 1003 ETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+Y +Q E+ R+K+ K LE ++ + + A ++++
Sbjct: 1905 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1946
Score = 53.2 bits (122), Expect = 5e-06
Identities = 174/899 (19%), Positives = 351/899 (39%), Gaps = 80/899 (8%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL--QDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
+L GA ++ D+ ++N +K+ + I + +S K S N+ + LS EL
Sbjct: 1133 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1192
Query: 84 IK-EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+K E + L+ L T+ + K+LE E TK+ E + + D + + + E
Sbjct: 1193 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--TKNHEAQ-IQDMRQRHATALEE 1249
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L E+ + NL K L+ +N+ L + L+++ ESE+K K +
Sbjct: 1250 LSEQLEQAKRF-------KANLEKNKQGLETDNKELACEVKVLQQVKAESEHK--RKKLD 1300
Query: 203 AQCK---LKENLIQSLHIGYDNTLSKLNRSISDSNT-----STRYNKICTLQSELDAGRE 254
AQ + K + L + SKL + + +T + K + L++ +
Sbjct: 1301 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1360
Query: 255 DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLI 314
D +EL ++ T K +L + L+E+ E + + + +++ + +L QL
Sbjct: 1361 DTQELLQEETRQKLNLS----SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1416
Query: 315 NNESKKSKD--HIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNII---NKYQIDLDEI-- 366
+ + K D I+ +++ +L DAE + L+ + D + N+ Q +LD++
Sbjct: 1417 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1476
Query: 367 -LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEISSAVTI 424
L+ +V +L + + + + S++++ E+ + +KE + ++ A+
Sbjct: 1477 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1536
Query: 425 DIVKKEN--ELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
+ KE + L + L K D+ +++ +L K+ AL Q E RT
Sbjct: 1537 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV-HELEKSKR------ALEQQVEEMRTQ 1589
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
E +++L+ + T +E + E K L L K +V E
Sbjct: 1590 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL------LIK-QVRE 1642
Query: 543 NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLN 602
A L E + + A+A +K + + KD L + N ++E +K L
Sbjct: 1643 LEAEL--------EDERKQRALAVASKKKMEIDLKD--LEAQIEAANKARDE--VIKQLR 1690
Query: 603 DVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ + K+ Q ELE + + + F K L + A+
Sbjct: 1691 KLQAQMKDYQR-ELEEA-RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1748
Query: 663 EQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
EQ E +E T S + ++ ++ R I +L+++++E+ +
Sbjct: 1749 EQER--DELADEITNSASGKSALL---DEKRRLEAR-IAQLEEELEEEQSNMELLNDRFR 1802
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
+ T + + L + A + S A QL Q ++ ++ ELE ++++ AT+
Sbjct: 1803 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1862
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSC 840
N+ + K K + D Q KE++
Sbjct: 1863 AKIGQLEEQLEQEAKERAAA--NKLVRRTEK---KLKEIFMQVEDERRHADQYKEQMEKA 1917
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ LK + +E ++E ++ + + L ++VS LK ++R P+
Sbjct: 1918 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1976
>X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin heavy
chain protein.
Length = 881
Score = 91.1 bits (216), Expect = 2e-17
Identities = 171/854 (20%), Positives = 336/854 (39%), Gaps = 52/854 (6%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD 282
L++L+ I+ N + + KI EL+ D +E + + +N E + DL
Sbjct: 5 LARLDDEIAQKNNALK--KI----RELEGHISDLQEDLDSERAARNKAEKQK----RDLG 54
Query: 283 EKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGT 342
E+L E + E + + ++ L + EQ + KK+ D R ++ + + +
Sbjct: 55 EEL-EALKTELEDTLDSTATQQELRAKREQEVT-VLKKALDEETRSHEAQVQEMRQKHAQ 112
Query: 343 TSLDVFEILMDNIINKYQIDLD-EILEKYTK-VQGDLNECTSELKSVNEKLASLNSQLIE 400
++ E L K +D + + LEK + G+L + V K L +Q+ E
Sbjct: 113 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 172
Query: 401 KENACNI---LRIQ-KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRD 454
++ C+ R + +++H++ + V ++ + E E K I L K+ LS D
Sbjct: 173 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 232
Query: 455 LDQDLPAHKKITILFDALITQYEL--SRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXX 511
L ++ ++ L + + D E+E K+ L T
Sbjct: 233 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 292
Query: 512 XXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
+ LEE + E LT+ Y+ K + L +E+D L + + + +
Sbjct: 293 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 352
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
+L +K K +L++ + + + + REKET+A L R+ + + EL+
Sbjct: 353 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 412
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
+ M L + AL+ Q EE LE ++ E
Sbjct: 413 RTNK---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 469
Query: 692 TAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ 751
A+++ + M+ K E D ++ + NE K L+R +LE R+
Sbjct: 470 -AKLRLEVNMQALKGQFERD---LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRAL 523
Query: 752 LTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
K +EG + +LE + D R+L E+
Sbjct: 524 AAAAKKKLEGDLKDLE----------LQADSAIKGREEAIKQLRKLQAQMKDFQREL-ED 572
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
+ + + ++ + L+ L+ Q++L + K+ D E E AE L
Sbjct: 573 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 632
Query: 872 CARLKKEKLSLEQQVSNLKEQIRTQQP-----VERQAKFADVAVNTDEDWANLHSVVVDR 926
L+ EK LE +++ L+E++ +Q +R K A + A S
Sbjct: 633 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 692
Query: 927 MSYDAEVEK-NKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKK-DKEFEAKRKELED 983
S ++E+ NK L + E+ K K+T+ ++ + + ++ ++E K+ +
Sbjct: 693 ESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 752
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
K + ++LK+ ++++E + +Y +Q E+ R+K+ K LE ++ S + A +++
Sbjct: 753 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 812
Query: 1044 E-SLSNTPVSNSTM 1056
+ L SN M
Sbjct: 813 QRELDEATESNEAM 826
Score = 62.1 bits (144), Expect = 1e-08
Identities = 108/554 (19%), Positives = 221/554 (39%), Gaps = 38/554 (6%)
Query: 550 IKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVSTINGL----------KEENNSL 598
I L E++D+ + A K E++ L E+ L TEL T++ ++E L
Sbjct: 29 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 88
Query: 599 KSLNDVITREKETQASEL-ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE 657
K D TR E Q E+ ++ Q +++ +L++ K E
Sbjct: 89 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 148
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
+ L + ++ + ++ L+ E+ N + +LQ +++ +
Sbjct: 149 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM---- 204
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
LNE K L +D + L+ ++E + + T QK V ++ +LE + + Q
Sbjct: 205 ---LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 261
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLKER 836
+ +D + L++ KR I + ++Q E
Sbjct: 262 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN--LTQQYEE 319
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ +L+ K R L E + L + + + L+K++ +Q ++ K I ++
Sbjct: 320 KAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-ISSK 375
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDLKN 955
ER A+ A + +L + + + E+E+ +++K +E+L K D+
Sbjct: 376 YADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 434
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETCAE 1007
V +++K+ + +E + + +EL ED K LE Q K + + + + E
Sbjct: 435 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 494
Query: 1008 YLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSAIV 1065
+++ Q +R L E + LE K A +K++E L + + + AI
Sbjct: 495 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 554
Query: 1066 QNQQITDVMKENQK 1079
Q +++ MK+ Q+
Sbjct: 555 QLRKLQAQMKDFQR 568
Score = 60.9 bits (141), Expect = 2e-08
Identities = 120/607 (19%), Positives = 249/607 (41%), Gaps = 46/607 (7%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
DT E E + TKL + + + N+ L L EE++A + + LS
Sbjct: 228 DTQELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAKQNLERHISTLNIQLS 283
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
+ KL + ST+ L+E + + +T++ E +A+ ++ + + ELD +
Sbjct: 284 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 343
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
D+ ++ + +Q LA ++ K D R + EK +
Sbjct: 344 DL--------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAREKETKA 394
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
+ + L++ ++ ++L E+ K+ L + E L D K++ ++ L TQ
Sbjct: 395 LS-LARALEEALEAKEEL--ERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 449
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR-----DLGE 810
+ ++ ++ ELE +++ + A + +E R L E
Sbjct: 450 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 509
Query: 811 -NPKLDDSPK-RSISVISDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQE 867
+L+D K R+++ + ++ LK+ L + +E K+L ++ +E
Sbjct: 510 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 569
Query: 868 -------RDEQCARLK---KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA 917
RDE A K K+ SLE + L+E + ER K AD+ +E
Sbjct: 570 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA---AERARKQADL--EKEELAE 624
Query: 918 NLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
L S + R + E + R+ + EEL ++ +++ +++KA ++ + E
Sbjct: 625 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 684
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL--EIVDKLSN 1034
+R + ++ ++L+++ KEL + +K + + EAKIA E V++ +
Sbjct: 685 ERSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 744
Query: 1035 QKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKR 1094
+K A K ++ + + + V + + Q K N ++K++ +L ++
Sbjct: 745 EKQAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKEQAEKGNARVKQLKRQLEEAEEES 802
Query: 1095 GKTGANR 1101
+ ANR
Sbjct: 803 QRINANR 809
Score = 59.7 bits (138), Expect = 6e-08
Identities = 154/872 (17%), Positives = 330/872 (37%), Gaps = 69/872 (7%)
Query: 101 ETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENV 158
E ++ + +I+ LE + +L +D + + + K K+ +L EE + L + E+
Sbjct: 11 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR--DLGEELEALKTEL-EDT 67
Query: 159 TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE-NKIGPKNICAQCKLKENLIQ--SL 215
+S +E+ ++ + +K +D E +E++ ++ K+ A +L E L Q
Sbjct: 68 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 127
Query: 216 HIGYDNTLSKLNRSISDSNTSTRY-----NKICTLQSELDAGREDCKELCEDFTSIKNHL 270
D L + +D R ++ + +L+A ++ + C D + L
Sbjct: 128 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 187
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ +++ G NE E KA+K+ ++ SLS QL + + ++ R K
Sbjct: 188 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA----SLSSQLQDTQELLQEE--TRQKL 241
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
++ +T L E N Q LDE +E ++ ++ +L +K
Sbjct: 242 NV---------STKLRQLE----EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 288
Query: 391 LASLNSQLIEKENACNILRIQKERI---HEISSAVTIDIVKKENELKEILTKECLKLSKL 447
L S + E + + E + +E +A + K +N L++ L + L
Sbjct: 289 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL--- 345
Query: 448 KIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXX 507
D R L +L ++ FD L+ + + + Y E+++ E +
Sbjct: 346 --DNQRQLVSNLEKKQR---KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 400
Query: 508 XXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-ILSEEIDALKIAIAK 566
+ LE + +K+ E+L K V +N L K L +++ +K + +
Sbjct: 401 LEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEE 459
Query: 567 NEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDVITREKETQASELERSCQ-VIK 624
E+++ + + +L + + G E + + N+ R+ + Q E E + K
Sbjct: 460 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 519
Query: 625 QNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
Q K++ D+ + + L Q + + E+
Sbjct: 520 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 579
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
+ K +EK A+ +M+LQ+ + ++ + + + EL ++
Sbjct: 580 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA--------------EE 625
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXXXXXXXXXXXXXXXX 798
L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 626 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 685
Query: 799 XTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDE 857
+ +N + + + RS + + + S+ K + + + ++ L+E+ ++ E
Sbjct: 686 RSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 745
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA 917
+ + L+++D++ + + + KEQ +Q K +
Sbjct: 746 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 805
Query: 918 NLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
N + + R D E N+ + + + L+ K
Sbjct: 806 NANRRKLQR-ELDEATESNEAMGREVNALKSK 836
Score = 52.4 bits (120), Expect = 9e-06
Identities = 129/636 (20%), Positives = 250/636 (39%), Gaps = 70/636 (11%)
Query: 39 ETQSNPIKL-QDSGTITISCKMCQSL--KESSNEINL--KLEKLSGELFDIKEQ-KSALE 92
E + IKL +D +++ + Q L +E+ ++N+ KL +L E +++Q +E
Sbjct: 207 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 266
Query: 93 GKYQNLILETQTRDLLMSQ-----------IKSLEMENLTKDKEIKNLTDSLKTKSKKIN 141
K QNL T ++ +S +++LE KEI+NLT + K+ +
Sbjct: 267 AK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 325
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+L++ + L + + V + DN + V +L+K Q + EK ++ +K +
Sbjct: 326 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNIS---SKYADERD 381
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSE-LDAGREDCKELC 260
A+ + +E ++L + L ++ R NK+ + E L + ++D +
Sbjct: 382 RAEAEAREKETKALSLA-----RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 436
Query: 261 EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK-------VMSEIKRNLNSLSEQL 313
+ K LE M L+E E E ++ + + +R+L + EQ
Sbjct: 437 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ- 495
Query: 314 INNESKK---------SKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLD 364
N E ++ + D K LA + L E+ D+ I +
Sbjct: 496 -NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK----GRE 550
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
E +++ K+Q + + EL+ + + E E L ++ E +A
Sbjct: 551 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA-- 608
Query: 425 DIVKKENEL-KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDY 483
+ +K+ +L KE L +E S L R+ QD +++ L + E + +
Sbjct: 609 ERARKQADLEKEELAEEL--ASSLS---GRNALQD--EKRRLEARIAQLEEELEEEQGNM 661
Query: 484 EIEKEKLRLETGTAKAVX---XXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
E +++R T A+ + LE + E++S E+ KSK
Sbjct: 662 EAMSDRVRKATQQAEQLSNELATERSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKF 721
Query: 541 DENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING---LKEENN 596
A L I L E+++ + + SL +KD KL E++ + + E+
Sbjct: 722 KSTIAALEAKIAQLEEQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 778
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+ ++ + Q E E Q I N +L +
Sbjct: 779 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 814
Score = 50.4 bits (115), Expect = 3e-05
Identities = 134/709 (18%), Positives = 282/709 (39%), Gaps = 62/709 (8%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN 119
C + + E+N K+ KL E+ + + EGK L + + L SQ++ + +
Sbjct: 177 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---LSSQLQ--DTQE 231
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT 179
L +++ + L S K+ +L+EE ++L + + E + NL + + L
Sbjct: 232 LLQEETRQKL-----NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 286
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+K D V E G K + ENL Q Y+ + ++ N
Sbjct: 287 KKLQDFASTVEALEE--GKKRFQKEI---ENLTQQ----YEEKAAAYDKLEKTKN----- 332
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
LQ ELD D ++ + ++LE + L E+ ++++ + +
Sbjct: 333 ----RLQQELD----DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 384
Query: 300 SEIK-RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+E + + +LS E+ ++K+ ++R L A ++ + ++ DV + + + + K
Sbjct: 385 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHE--LEK 441
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNE-KL-ASLNSQLIEKENACNILRIQKERIH 416
+ L+ +E +++ L E EL++ + KL +N Q ++ + + L+ + E+
Sbjct: 442 SKRALETQME---EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNE 497
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKKITILFDAL--I 473
E + + + E EL++ + L + K + DL D +L A I +A+ +
Sbjct: 498 EKRRQLQRQLHEYETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQL 556
Query: 474 TQYELSRTDYEIEKEKLRLET----GTAKAVXXXXXXXXXXXXXXFDTL---EEAHNEVK 526
+ + D++ E E R TAK + L E A +
Sbjct: 557 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 616
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
EEL + S + NA + + L I L+ + + + M ++S++ K T+
Sbjct: 617 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 676
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
++ S N+ ++ E Q EL RS ++ + G K K+ I
Sbjct: 677 QLSNELATERSTAQKNESSRQQLERQNKEL-RS-KLHEMEGAVKSKFKSTI-------AA 727
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
++ + + A + ++K + + + ++ K AE + +
Sbjct: 728 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 787
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
+++ + E E + + L+R+ D A + E+ VN L ++
Sbjct: 788 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 836
Score = 34.3 bits (75), Expect = 2.5
Identities = 42/172 (24%), Positives = 73/172 (42%), Gaps = 13/172 (7%)
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK----EFEAKRKELE--- 982
D E+ + +K I EL DL+ + + A K K+ + E EA + ELE
Sbjct: 9 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 68
Query: 983 DCKAELEELK-QRYKELDEECETCAEYLKQREEQCK--RLKEAKIALEIVDKLSNQKVAL 1039
D A +EL+ +R +E+ + E + E Q + R K A+ E+ ++L K A
Sbjct: 69 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 128
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITIC 1091
++ N+ + G V Q +V + +KL+ +L + C
Sbjct: 129 ANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 177
>BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1,
skeletal muscle, adult protein.
Length = 1939
Score = 91.1 bits (216), Expect = 2e-17
Identities = 184/1040 (17%), Positives = 433/1040 (41%), Gaps = 92/1040 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 886 QEKNDLQLQVQAEADSLADAE------ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE 939
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ + + I +L +E
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E KI A+ K
Sbjct: 1000 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL-EQEKKIRMDLERAKRK 1058
Query: 207 LKENLIQSLHIGYDNTLSKLN-RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
L+ +L + ++T+ N + D + ++ LQS+++ + +L +
Sbjct: 1059 LEGDL----KLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE 1114
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL----------IN 315
++ +E +L+E++ KA K S++ R L +SE+L I
Sbjct: 1115 LQARIE--------ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1166
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSL------DVFEI--LMDNII----------N 357
K+ + +D A L E +L V E+ +DN+ +
Sbjct: 1167 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1226
Query: 358 KYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+ ++++D++ +E +K +G+L + +++ ++L+ + ++ E++ N L Q+ R
Sbjct: 1227 EMKMEIDDLASNMETVSKAKGNLEKMC---RALEDQLSEIKTKEEEQQRLINDLTAQRAR 1283
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
+ S + + +K+ + ++ + +++ ++ R L++++ A + +
Sbjct: 1284 LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIE-ELKRQLEEEIKAKSALAHALQSSRH 1342
Query: 475 QYELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL- 532
+L R YE E+E K L+ +KA EE K L + L
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402
Query: 533 -TKLYKSKVDENNANLNLIKI-LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+ + V+ A+L K L E++ L I + + +L +K ++++
Sbjct: 1403 DAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQ 1462
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
EE ++ + +E + ++EL + +++ +L+ +K +
Sbjct: 1463 KCEETHAELEASQ---KESRSLSTELFKIKNAYEESLDQLETLKRE----NKNLQQEISD 1515
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
E + + +K+Q E++ S L+ ++ E + E + I+R+Q ++ +
Sbjct: 1516 LTEQIAEGGKRIHELKKIKKQVEQEK---SELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI 770
E + K+ E + + +KR++ V+ ++S+ +A ++ ++ D + + ++E D+
Sbjct: 1573 KS---EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA--EIRSRNDAIRLK-KKMEGDL 1626
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
+ + D L + + + K ++++ +
Sbjct: 1627 NEME---IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRA 1682
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLK 890
+ L+ + + L+ + K + E +E +Q Q L K LE +S ++
Sbjct: 1683 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQ 1742
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKTIEELRYK 949
++ R A+ + A D A + + A +E+ K+ L +T+++L+++
Sbjct: 1743 GEMEDIIQEARNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800
Query: 950 KQD-----LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
+ LK ++QK + + + E E+++K + L + +++ KEL + E
Sbjct: 1801 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEE 1860
Query: 1005 CAEYLKQREEQCKRLKEAKI 1024
+ + + ++ +L +AK+
Sbjct: 1861 DRKNILRLQDLVDKL-QAKV 1879
Score = 76.6 bits (180), Expect = 5e-13
Identities = 95/520 (18%), Positives = 206/520 (39%), Gaps = 25/520 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
A+ E++M ++ E+ K E ++ ++E L+ + +EK +++ +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKE---LEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
D++ + + L + L+++C E +D LE+
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
+ EK + L +++ D ET + +LT + +AL+ + + DL++
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLD------ET-IAKLTKEKKALQEAHQQTLDDLQA 1016
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ VN LT K +E ++ +LE + E+ + ++
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076
Query: 805 NRDLGENPKLDDSPKRSI-SVISDSEV--SQLKERLLSCQQELDDLKERYKELDDECETC 861
+ L E K + + S I D + QL++++ Q +++L+E E++ E +
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE---EIEAERASR 1133
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
A+ ++R + L++ LE+ QI + +R+A+F + + +E +
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEA 1191
Query: 922 VVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ E+ L + ++L +K ++K + + ME +K E
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LED +E++ ++ + L + L+ + R + K L V +LS K
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL--VSQLSRGK 1309
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
A +QIE L A A+ ++ D+++E
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE 1349
Score = 71.3 bits (167), Expect = 2e-11
Identities = 192/982 (19%), Positives = 376/982 (38%), Gaps = 100/982 (10%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
+IK L S +T+ + N +E T L + K V +++ N+ Q +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 185 LEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICT 244
+ L + E C Q +K + I ++ I+ T+ + K+
Sbjct: 899 ADSLADAEER-------CDQL-IKTKIQLEAKIKEVTERAEDEEEINAELTAKK-RKLED 949
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI-K 303
SEL +D + K+ E N+T ++ L E TK K + E +
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQ 1008
Query: 304 RNLNSL-SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+ L+ L +E+ N K+K +++ D L L+ E + ++ K + D
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE------KKIRMDLERAKRKLEGD 1062
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L E ++ D + +LK +++ L S+ IE E A +++QK +I E+ + +
Sbjct: 1063 LKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK-IEDEQALG-MQLQK-KIKELQARI 1119
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRT- 481
+ E E++ K K + D+ R+L++ +++ A Q E+++
Sbjct: 1120 E----ELEEEIEAERASRA-KAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNKKR 1171
Query: 482 DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN--EVKSLHEELTKLYKSK 539
+ E +K + LE T + + E+ N VK E+ K +
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1231
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+D+ +N+ + ++ + A+ E+++ + K+ + L IN L + L+
Sbjct: 1232 IDDLASNMETVSKAKGNLEKMCRAL---EDQLSEIKTKEEEQQRL---INDLTAQRARLQ 1285
Query: 600 SLNDVITR---EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + +R EK+T S+L R Q Q EL + + +
Sbjct: 1286 TESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI------------------ 1327
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
+AKS AL + DC L + +E+ E + + + K E + +
Sbjct: 1328 KAKS------ALAHALQSSRHDCDLLR---EQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
ET + T + E K+ ++D E EAVN + + R+ D+ +
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
T +E + +L+ S K S S+ +E+ ++K
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKESRSL--STELFKIKNA 1491
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+L+ LK K L E E + E ++ LKK K +EQ+ S L
Sbjct: 1492 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELKKIKKQVEQEKSEL------- 1544
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
QA + + + + + + ++ +EV+ +++ + EE+ K++
Sbjct: 1545 -----QAALEEAEASLEHEEGKILRIQLELNQVKSEVD--RKIAEKDEEIDQMKRNHIRI 1597
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
V MQ ++ + + +K++E +L E++ +L+ AE L+
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKME---GDLNEME---IQLNHANRMAAEALRNYRNTQ 1651
Query: 1017 KRLKEAKI----ALEIVDKLSNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQIT 1071
LK+ ++ AL + L Q +E++ L + +T+ S + Q++
Sbjct: 1652 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL 1711
Query: 1072 DVMKENQKLKKMNAKLITICKK 1093
D + Q L N LI KK
Sbjct: 1712 DASERVQLLHTQNTSLINTKKK 1733
Score = 64.9 bits (151), Expect = 2e-09
Identities = 119/600 (19%), Positives = 255/600 (42%), Gaps = 42/600 (7%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE 576
LE+ +E+K ++L +L +KV+ E +A N +K L+EE+ L IAK ++ +L E
Sbjct: 947 LEDECSELKKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ T++ L+ E + + +L + E Q +LE S + K+ +L++ K
Sbjct: 1006 AHQQ------TLDDLQAEEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKIRMDLERAKRK 1058
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE----QCEEKTRDCSRLEINIKTHEKT 692
+ + K L++ L KE + K D L + ++ +K
Sbjct: 1059 L----EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQ--KKI 1112
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD------AAVKDLESSR 746
E+Q R I L+++I+ + + E + ++L+ + E + + +A ++ R
Sbjct: 1113 KELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 747 EAVNQLTTQKDLVEGRIAE--LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT-FGD 803
EA Q ++DL E + + +R + +V +
Sbjct: 1172 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 804 ENRDLGENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
E DL N + K ++ + + ++S++K + Q+ ++DL + L E
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE 1290
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ L E+D ++L + K + QQ+ LK Q+ ++ ++ ++ A ++ D L
Sbjct: 1291 YSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL--EEEIKAKSALAHALQSSRHDCDLLR 1348
Query: 921 SVVVDRMSYDAEVEK-NKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
+ AE+++ + + + R K + D ++++A +K ++ ++ E
Sbjct: 1349 EQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKV 1037
+ + A LE+ KQR L E E +++ C L K+ + +I+ + +
Sbjct: 1409 EAVNAKCASLEKTKQR---LQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 1038 ALEKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
++E+ S ST +A ++ Q+ + +EN+ L++ + L + GK
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525
Score = 59.3 bits (137), Expect = 8e-08
Identities = 177/981 (18%), Positives = 385/981 (39%), Gaps = 75/981 (7%)
Query: 105 RDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL----SNLIMENVTE 160
+ LL S EM N+ ++ E K + KT++K+ EL+E+ TL ++L ++ E
Sbjct: 841 KPLLKSAETEKEMANMKEEFE-KTKEELAKTEAKR-KELEEKMVTLMQEKNDLQLQVQAE 898
Query: 161 SDNLNKEVDDLKKNNECLTQKCIDLEKLVNE-SENKIGPKNICAQCKLKENLIQSLHIGY 219
+D+L D ++ + L + I LE + E +E + I A+ K+ ++
Sbjct: 899 ADSLA----DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 220 DNTLSKLNRSIS--DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
+ L +++ + NK+ L E+ E +L ++ +++ E H+
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ---EAHQQT- 1010
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
LD+ E ++ T K ++++ ++ L L + KK + ++R K L L
Sbjct: 1011 ---LDDLQAEEDKVNT-LTKAKIKLEQQVDDLEGSL--EQEKKIRMDLERAKRKLEGDLK 1064
Query: 338 -AEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ T ++ + +D + K + ++ + K Q + ++K + ++ L
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 397 QLIEKENACNILRIQKER------IHEISSAVTIDIVKKENELKEILTKECLKLSKLKID 450
+ IE E A + +K+R + EIS + + + E+ K + K++ D
Sbjct: 1125 E-IEAERASRA-KAEKQRSDLSRELEEISERLE-EAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 451 IPR-DLDQDLPA---HKKITILFDALITQYE-LSRTDYEIEKEK--LRLETGTAKAVXXX 503
+ L + A KK L Q + L R ++EKEK +++E +
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 504 XXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY----------KSKVDENNANLNLIKIL 553
LE+ +E+K+ EE +L +++ E + L+ L
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
++ K A + E++ E++ K ++ + L+ + L + E+E +A
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA--HALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 614 SELERSCQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
EL+R+ + K + D + +A+ +E A+ +C
Sbjct: 1360 -ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE---AVNAKC 1415
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK 732
+ RL+ ++ E N L K+ + DK+ E + K E + EA +
Sbjct: 1416 ASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1475
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXX 790
++ + +L + A + Q + ++ L+ +I TEQ A
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELKKIKK 1535
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
E + + + ++ I + + S++ ++ +E+D +K
Sbjct: 1536 QVEQEKSELQAALEEAEA--SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN 1593
Query: 851 YKELDDECETCAEYLQERDEQCARLKKE------KLSLEQQVSN------LKEQIRTQQP 898
+ + + ++ + RLKK+ ++ ++ +N L+ TQ
Sbjct: 1594 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAI 1653
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSY-DAEVEKNKRLMKTIEELR-YKKQDLKNT 956
++ D A+ + ED ++V R + AE+E+ + ++ E R +Q+L +
Sbjct: 1654 LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
++Q + T + ++ + E+E++ Q + +E+ + E+
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773
Query: 1017 KRLKEAKIALEIVDKLSNQKV 1037
K+ ++ LE + K Q V
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTV 1794
Score = 57.6 bits (133), Expect = 2e-07
Identities = 73/408 (17%), Positives = 175/408 (42%), Gaps = 15/408 (3%)
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVK 740
+L IK K+AE + M ++++ ++ + + E K EL K L ++ +
Sbjct: 835 KLYFKIKPLLKSAETEKEMA-NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 741 DLESSREAVNQLTTQKD-LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+++ +++ + D L++ +I +LE+ I+ T
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKI-QLEAKIKE---VTERAEDEEEINAELTAKKRKLED 949
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
+ +D+ ++ +L + ++++V L E + + + L + K L + +
Sbjct: 950 ECSELKKDI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
+ LQ +++ L K K+ LEQQV +L+ + ++ + + A + D A
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
++ ++ + EK K+ + L+ K +D + ++QK +++ + +E E +
Sbjct: 1069 STMDIENDKQQLD-EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE---E 1124
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL 1039
E+E +A + +++ +L E E +E L E+ A+I + + QK+
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 1040 EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + +L + + + S +QI ++ + QKL+K +++
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1228
>Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein.
Length = 1356
Score = 90.6 bits (215), Expect = 3e-17
Identities = 214/1077 (19%), Positives = 422/1077 (39%), Gaps = 116/1077 (10%)
Query: 48 QDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ--- 103
+D+ CK + Q + N+ + ++ + ++++ + + K ETQ
Sbjct: 345 EDAAATKDRCKQLTQEMMTEKERSNVVMTRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQ 404
Query: 104 -----TRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK-SKKINELQEENDTLSNLIMEN 157
R+ + ++I L+ EN + N T+ L++K S ++N+L+++ L N + E
Sbjct: 405 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 464
Query: 158 V-------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK 208
+ N + LK + ++ +++ + + +E++ +++ ++ K
Sbjct: 465 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK 524
Query: 209 ENLIQSLHIGYDNTL---SKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDF 263
EN +QSLH +TL +L + + + R NK +LQ ++ E + L
Sbjct: 525 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 584
Query: 264 TSIKNHL--ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESK 319
+ + + + +L + + E ++ + ++ + L S E+L I N +
Sbjct: 585 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 644
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K + + + A + + D+ I + L + + LN+
Sbjct: 645 LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 704
Query: 380 CTSELKSVNEKLASL-----NSQLIEKENACNILRIQK-ERIHEISSAVTIDIVKKENEL 433
LKS +KL +L N ++E+ C + +K + + E+ I + KE EL
Sbjct: 705 QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 764
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
I T+ S L ++ QDL A + + F +L+ EL + +E +
Sbjct: 765 NAIRTEN----SSLTKEV-----QDLKAKQNDQVSFASLVE--ELKKVIHE--------K 805
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
G K+V T+++ E+K+L EE+ + K + L++ +
Sbjct: 806 DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ----LSITSKV 861
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKE 610
E + LK + L EK+ L + L+EEN SLK+ + + ++
Sbjct: 862 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 921
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ AS+ E V+K+ G EL +++A + DE K Q LK+
Sbjct: 922 SSASQFEELEIVLKEKGNELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 981
Query: 671 QCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA 730
Q ++ + HE+ L K I E +K E NEL + +A
Sbjct: 982 QNYQQAS-------SFPPHEE-----------LLKVISEREK---EISGLWNELDSLKDA 1020
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
++ E + EA+ L + + +++ ++ + + R +Q V
Sbjct: 1021 VEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE-RQQQVEAVELEAKEVLKKLF 1079
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLK-- 848
++G+ + K ++ S SE ++ E L E+ L
Sbjct: 1080 PKVSVPSNLSYGEWLHG------FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQL 1133
Query: 849 --ERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
E+YK + E E + LQ EQ K K+ +++ +K+ Q +
Sbjct: 1134 ECEKYKSVLAETEGILQKLQRSVEQ--EENKWKVKVDESHKTIKQM---QSSFTSSEQEL 1188
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAME 965
+ + ++D NL +R + E+EK + T + E+R +LK+ +T++QK
Sbjct: 1189 ERLRSENKDIENLRR---EREHLEMELEKAEMERSTYVTEVR----ELKDLLTELQK--- 1238
Query: 966 KYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIA 1025
K E + +EL KA+L E + + E + A L + +Q L ++KI
Sbjct: 1239 KLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL-HKAQQSLELIQSKIV 1297
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
K + +E S TM V+ + Q QQ+ + NQ+L K
Sbjct: 1298 -----KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV--NQQLTK 1347
Score = 65.3 bits (152), Expect = 1e-09
Identities = 121/596 (20%), Positives = 255/596 (42%), Gaps = 45/596 (7%)
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTEL 584
KS ELT L +++ L+ + E+ A K + ++M++ E+ N +T +
Sbjct: 320 KSSKGELTTLIHQLQEKDK----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVMTRM 375
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI-LMXXXX 643
I L++E+N + N + +ETQ +++ QV +Q E+ +K + ++
Sbjct: 376 KDRIGTLEKEHNVFQ--NKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAV 432
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E L + L + EKT + E+ K E+ A +L
Sbjct: 433 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-------QL 485
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRD----YDAAVKDLESSREAVNQLTTQKDLV 759
+ Q+QE ++ + E ++ + + T ++EA ++D + A +++S + K +
Sbjct: 486 KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL 545
Query: 760 EGRIAEL-ESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD--LGEN-P 812
E R+ +L ES+ + E++ + + L E
Sbjct: 546 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH 605
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
K+ + I DS S+ ++RL S ++EL D++ L E + E+
Sbjct: 606 KVIAEKDKQIKQTEDSLASE-RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 664
Query: 873 ARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
L+K + S+ + ++ L+EQ++ E K + + D++ A L S V +
Sbjct: 665 HELEKMQQSVYVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKA-LKSEVQKLQTL 719
Query: 930 DAEVEKNKRLMKTIEE-LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E + NK +++ +E+ ++ K + LK ++ + + K++E A R E E+
Sbjct: 720 VSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 778
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVA---LEKQIE 1044
++LK + + E K E+ ++K + LE + K++N++ L+++I+
Sbjct: 779 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 838
Query: 1045 SLSNTPVSNSTMYVATGSAIVQN-QQITDVMK-ENQKLKKMNAKLITICKKRGKTG 1098
+L + N + A +I Q++ +++K + +++ M A L K TG
Sbjct: 839 ALKE-EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 893
Score = 59.3 bits (137), Expect = 8e-08
Identities = 178/858 (20%), Positives = 342/858 (39%), Gaps = 69/858 (8%)
Query: 39 ETQSNPIKLQDS--GTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ 96
E QS KL D+ + ++ Q ++ +N K E L ++ DI EQ AL+ + Q
Sbjct: 527 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN-KEESLQMQVQDILEQNEALKAQIQ 585
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN---L 153
+ + + L KDK+IK DSL ++ ++ +EE + N L
Sbjct: 586 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 645
Query: 154 IMENVTESDNLNKE----VDDLKKNNECLTQKCIDL----EKLVNESENKIGP-KNICAQ 204
+ V + L E +L+K + + K + E+L +E NK+ K + Q
Sbjct: 646 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 705
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
K ++ +Q L +K + + K+ T++ L+ G E+
Sbjct: 706 NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELN 765
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFET---KAVKVMSEIKRNLNSLSEQLINNESKK- 320
+I+ DL K + F + + KV+ E + S+ E+L+ E K
Sbjct: 766 AIRTE-NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV-EELLEAELLKV 823
Query: 321 -SKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL----EKYTKVQG 375
+K+ + + L E G L+ + L +I +K Q +L +L E+ ++
Sbjct: 824 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL--SITSKVQ-ELQNLLKGKEEQMNTMKA 880
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA---VTIDIVKKE-- 430
L E +L + + L L + + ++ + + + E SSA ++IV KE
Sbjct: 881 VLEEKEKDLANTGKWLQDLQEE--NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKG 938
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKL 490
NELK + + LK + + L QD+ K LF + I Q L + +Y+ +
Sbjct: 939 NELKRL--EAMLKERESDLSSKTQLLQDVQDENK---LFKSQIEQ--LKQQNYQ-QASSF 990
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
K + ++ L+ + V+ ++ L + + A +
Sbjct: 991 PPHEELLKVI----SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1046
Query: 551 KILSEEIDALKIAIAKNEEKM-LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK 609
K+L ++++ + E + L E KL VS + L + L+ + K
Sbjct: 1047 KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYG----EWLHGFEKKAK 1102
Query: 610 ETQA-SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ-NLA 667
E A + +V++ E D+M + + + + +EQ
Sbjct: 1103 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1162
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAE---IQNRMIMRLQKQIQEDDKLFIEK-ETKLNE 723
K + +E + +++ + + E+ E +N+ I L+++ +E ++ +EK E + +
Sbjct: 1163 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE-REHLEMELEKAEMERST 1221
Query: 724 LTNKYEALKRDYDAAVKDLESS-REAVNQLTTQKDLVEGRIAELESDIRTEQ-----TAT 777
+ LK K L+ S EAV Q + +L++ ++ E + +RTEQ A
Sbjct: 1222 YVTEVRELKDLLTELQKKLDDSYSEAVRQ-NEELNLLKAQLNETLTKLRTEQNERQKVAG 1280
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
T EN D+ +P+ + S K ++SV + V+QL++ L
Sbjct: 1281 DLHKAQQSLELIQSKIVKAAGDTTVIENSDV--SPETESSEKETMSVSLNQTVTQLQQLL 1338
Query: 838 LSCQQELDDLKERYKELD 855
+ Q+L KE Y+ L+
Sbjct: 1339 QAVNQQLTKEKEHYQVLE 1356
Score = 43.6 bits (98), Expect = 0.004
Identities = 56/276 (20%), Positives = 123/276 (44%), Gaps = 16/276 (5%)
Query: 814 LDDSPKRSISVISDSEVSQLKER---LLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ D+ K+S + + QL+E+ L + +++ K+R K+L E T E +
Sbjct: 314 IQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE---RSNV 370
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRT--QQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
R+K +LE++ + + +I Q+ + Q KF V + + A+L + +
Sbjct: 371 VMTRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQE--NGIL 428
Query: 929 YDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
DA +L K EL +QD V ++ + K +++ + + + K +
Sbjct: 429 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 488
Query: 988 LEELKQRYKELDE--ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L+E ++R++E+ T Q++ Q K + + + KL++ V+ ++Q+E
Sbjct: 489 LQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-KQQLEQ 547
Query: 1046 LSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK 1081
+ + V ++ Q+ D++++N+ LK
Sbjct: 548 RLMQLMESEQKRVNKEESL--QMQVQDILEQNEALK 581
Score = 42.3 bits (95), Expect = 0.009
Identities = 129/600 (21%), Positives = 237/600 (39%), Gaps = 62/600 (10%)
Query: 516 DTLEEAHNEVKSLHE-ELTKL---YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
D + N+++S EL KL Y V+E K+ EE+ A + K+
Sbjct: 430 DAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTG--KLQQEEVQKKNAEQAATQLKV 487
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKS--LNDVITREKETQASELERSCQVIKQNGFE 629
L E + + E+ S I E+ + + + + +E E Q+ + + ++ + E
Sbjct: 488 -QLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLE 546
Query: 630 LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH 689
M+ LM + + +LEQN ALK Q ++ +I +T
Sbjct: 547 QRLMQ---LMESEQKRVNKEESLQM--QVQDILEQNEALKAQIQQ-----FHSQIAAQTS 596
Query: 690 EKT-AEIQNRMIMRLQKQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
AE +++I KQI Q +D L E++ LT+K E LK D L++ +
Sbjct: 597 ASVLAEELHKVIAEKDKQIKQTEDSLASERD----RLTSKEEELK-DIQNMNFLLKAEVQ 651
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ L ++ ELE + +Q+ V F N
Sbjct: 652 KLQALANEQ---AAAAHELE---KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN-- 703
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE 867
+N L ++ +++S+ + E++ C QE D E+ K +++ ET +
Sbjct: 704 -DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD---EKLKTVEELLETGLIQVAT 759
Query: 868 RDEQCARLKKEKLSLEQQVSNLK----EQIRTQQPVERQAKFA---DVAVNTDEDW---- 916
++E+ ++ E SL ++V +LK +Q+ VE K D + + E+
Sbjct: 760 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 819
Query: 917 ----ANLHSVVVD-RMSYDAEVEK--NKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYT 968
AN V D + A E+ N +L K + + K Q+L+N + ++ M
Sbjct: 820 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 879
Query: 969 ----KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
+K+K+ K L+D + E E LK +E+ + A Q EE LKE
Sbjct: 880 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKGN 939
Query: 1025 ALEIVDKLSNQKVA-LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
L+ ++ + ++ + L + + L + N QN Q +++L K+
Sbjct: 940 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 999
Score = 32.3 bits (70), Expect = 9.9
Identities = 33/153 (21%), Positives = 64/153 (41%), Gaps = 7/153 (4%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK 85
+ +G K +E + N K++ + S K + ++ S +LE+L E DI+
Sbjct: 1144 ETEGILQKLQRSVEQEENKWKVK----VDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1199
Query: 86 EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
+ E L R +++++ E+++L + + K L DS ++ EL
Sbjct: 1200 NLRREREHLEMELEKAEMERSTYVTEVR--ELKDLLTELQ-KKLDDSYSEAVRQNEELNL 1256
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
L+ + + TE + K DL K + L
Sbjct: 1257 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1289
>X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mRNA
for embryonic myosin heavy chain (SMHCE). ).
Length = 1085
Score = 90.6 bits (215), Expect = 3e-17
Identities = 204/1097 (18%), Positives = 434/1097 (39%), Gaps = 96/1097 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 28 QEKNDLQLQVQAESENLLDAE------ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 81
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ L + I +L E
Sbjct: 82 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 141
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ + + +
Sbjct: 142 KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-EQEKKL---RVDLE-R 196
Query: 207 LKENLIQSLHIGYDNTLSKLN-RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
K L L + ++ L N + D + + C LQS++ ED + L F
Sbjct: 197 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV----EDEQTLGLQFQK 252
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL----------IN 315
L+ +L+E++ K K S+ R L LSE+L I
Sbjct: 253 KIKELQAR----IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 308
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSL------DVFEI--LMDNI----------IN 357
K+ + + +D A L E +L V E+ +DN+ +
Sbjct: 309 LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 368
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
++++++D++ V +++ ++L+ + E + + + L QK R+
Sbjct: 369 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 428
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ ++ + +KE+ + + L++ ++ ++ R L+++ A + + +
Sbjct: 429 EAGELSRQLEEKESIVSQ-LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 487
Query: 478 LSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
L R YE E+E K L+ +KA EE EE K
Sbjct: 488 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL--------EEAKKKL 539
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
++ ++ + + ++ K + E ++ E+ N L + K++ N
Sbjct: 540 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD-----KKQRN 594
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
K L + T+ +E+QA ELE S + + EL K+K
Sbjct: 595 FDKVLAEWKTKCEESQA-ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 653
Query: 657 EAKSLLEQ---NLALKEQCEE--KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
E L EQ N + E+ K + + +I + E A +++ L+ Q+ E
Sbjct: 654 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL-ELT 712
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
++ E + K+ E + E LKR+Y V+ ++S+ +A ++ ++ + + + ++E D+
Sbjct: 713 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA--EVRSRNEAIRLK-KKMEGDLN 769
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
+ + D L + + + K ++++ + +
Sbjct: 770 EIE---IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV-ERRAN 825
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
L+ + + L+ + K + E E +Q Q L K LE + L+
Sbjct: 826 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 885
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKK 950
++ R A+ + A D A + + A +E+ K L +T+++L+++
Sbjct: 886 EVEDASRDARNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 943
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYL 1009
+ + Q A++ K+ ++ E + +ELE + + E ++ + K L + E
Sbjct: 944 DEAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELT 997
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
Q EE K + + ++VDKL + + ++Q E ++ T + + + ++
Sbjct: 998 YQSEEDRKNVLRLQ---DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEE 1054
Query: 1070 ITDVMKENQKLKKMNAK 1086
D+ + ++ K+ AK
Sbjct: 1055 RADIAE--SQVNKLRAK 1069
Score = 73.7 bits (173), Expect = 3e-12
Identities = 188/993 (18%), Positives = 384/993 (38%), Gaps = 98/993 (9%)
Query: 73 KLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE-IKNLTD 131
+ +K EL + ++ LE K L+ Q ++ L Q+++ E ENL +E L
Sbjct: 1 EFQKTKDELAKSEAKRKELEEKLVTLV---QEKNDLQLQVQA-ESENLLDAEERCDQLIK 56
Query: 132 SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE 191
+ KI E+ E + + E + L E +LKK+ + L +EK +
Sbjct: 57 AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 116
Query: 192 SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDA 251
+ENK+ +NL + L G D T++KL R + + LQ+E D
Sbjct: 117 TENKV------------KNLTEELS-GLDETIAKLTRE-KKALQEAHQQALDDLQAEEDK 162
Query: 252 GREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
K+ LE DL+ L + + + +++ +L E
Sbjct: 163 --------VNSLNKTKSKLE----QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 210
Query: 312 QLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYT 371
+++ E+ K + +R K + + I + Q ++E+ E+
Sbjct: 211 SILDLENDKQQLD-ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 269
Query: 372 KVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN 431
+ + + +L L+ +L E A + Q E ++ + +K
Sbjct: 270 AERATRAKTEKQRSDYARELEELSERL---EEAGGVTSTQIE----LNKKREAEFLKLRR 322
Query: 432 ELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR 491
+L+E + ++ L+ + D ++I L + + E ++++++E + L
Sbjct: 323 DLEEATLQHEAMVATLR---KKHADSVAELGEQIDNL-QRVKQKLEKEKSEFKLEIDDL- 377
Query: 492 LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL--YKSKVD----ENNA 545
+ + ++V D L EA + + + L++L KS++ E +
Sbjct: 378 --SSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 435
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
L + + ++ K A + E++ E++NK ++ + L+ + L +
Sbjct: 436 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA--HALQSSRHDCDLLREQY 493
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
E+E +A EL+R+ L K +++ +EAK L Q
Sbjct: 494 EEEQEGKA-ELQRA----------LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 542
Query: 666 LA-LKEQCEEKTRDCSRLE-----INIKTHEKTAEIQ--NRMIMRLQKQIQEDDKLFIEK 717
L +EQ E C+ LE + + + +++ N + L K+ + DK+ E
Sbjct: 543 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 602
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR--TEQT 775
+TK E + EA ++ + +L + A + Q + V+ LE +I TEQ
Sbjct: 603 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 662
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
A E + + +++ I + S++
Sbjct: 663 AENGKTIHELEKSRKQIELEKADIQLALEEAEAA--LEHEEAKILRIQLELTQVKSEIDR 720
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKE 891
++ +E++ LK Y+ + ++ + + RLKK + +E Q+S+
Sbjct: 721 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR 780
Query: 892 Q----IRTQQPVERQAK----FADVAVNTDEDWANLHSVVVDRMS-YDAEVEKNKRLMKT 942
Q ++ + V+ Q K D A+ ED ++V R + AEVE+ + ++
Sbjct: 781 QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 840
Query: 943 IEELR-YKKQDLKNTVTKMQKAMEK-----YTKKDKEFEAK--RKELEDCKAELEELKQR 994
E R +Q+L ++ ++Q + +TKK E + + E+ED + +++
Sbjct: 841 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 900
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
K+ + AE LK+ ++ L+ K LE
Sbjct: 901 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 933
Score = 69.7 bits (163), Expect = 5e-11
Identities = 185/894 (20%), Positives = 350/894 (39%), Gaps = 96/894 (10%)
Query: 245 LQSELDAGRE---DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV--- 298
LQ ++ A E D +E C+ K LE +T +++ N E K K+
Sbjct: 33 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 92
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--II 356
SE+K++++ L L E +K H K + L E + ++ + +
Sbjct: 93 CSELKKDIDDLELTLAKVEKEK---HATENK---VKNLTEELSGLDETIAKLTREKKALQ 146
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+Q LD++ + KV LN+ S+L+ E L S Q EK+ ++ R +++
Sbjct: 147 EAHQQALDDLQAEEDKVNS-LNKTKSKLEQQVEDLESSLEQ--EKKLRVDLERNKRKLEG 203
Query: 417 EISSAVT--IDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD---- 470
++ A +D+ + +L E L K+ + +L+ + + L KKI L
Sbjct: 204 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 263
Query: 471 ---------ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
A + E R+DY E E+L A V F L
Sbjct: 264 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 323
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
E HE + + K ++ A L E+ID L+ K E++ SE ++
Sbjct: 324 LEEATLQHEAMVATLRKKHADSVAELG------EQIDNLQRVKQKLEKEK---SEFKLEI 374
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
+L S++ + + +L+ I R E Q SE + I+++ EL K+ +
Sbjct: 375 DDLSSSMESVSKSKANLEK----ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEA 430
Query: 642 XXXXXXXXXXXXXXDEA----KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ ++ +Q LK Q EE+ + + L +++ ++
Sbjct: 431 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 490
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ-LTTQK 756
Q+ E + + +++ + KYE D ++LE +++ + Q L +
Sbjct: 491 EQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEAKKKLAQRLQDSE 547
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLD 815
+ VE A+ S +T+Q + ++ L E K +
Sbjct: 548 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 607
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+S ++ E S + R LS EL LK Y+E D+ ET +
Sbjct: 608 ESQ-------AELEASLKESRSLST--ELFKLKNAYEEALDQLET--------------V 644
Query: 876 KKEKLSLEQQVSNLKEQI----RTQQPVERQAK-----FADVAVNTDEDWANLHSVVVDR 926
K+E +LEQ++++L EQI +T +E+ K AD+ + +E A L
Sbjct: 645 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 704
Query: 927 MSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ E+ E ++++ + EE+ K++ + TV MQ A++ + E +K++
Sbjct: 705 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 764
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALE 1040
E +L E++ + + + ++L+ + Q K + AL + L Q +E
Sbjct: 765 E---GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 821
Query: 1041 KQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
++ L + +T+ + + Q++ D + Q L N LI KK
Sbjct: 822 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK 875
Score = 57.2 bits (132), Expect = 3e-07
Identities = 61/267 (22%), Positives = 126/267 (47%), Gaps = 22/267 (8%)
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
S+++ +L+E+L++ QE +DL +L + E +E L + +E+C +L K K LE +
Sbjct: 12 SEAKRKELEEKLVTLVQEKNDL-----QLQVQAE--SENLLDAEERCDQLIKAKFQLEAK 64
Query: 886 VSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEE 945
+ + E R + E A+ +++ + L + D A+VEK K +
Sbjct: 65 IKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN--- 119
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE---LEELKQRYKELDEE 1001
K ++L ++ + + + K T++ K EA ++ L+D +AE + L + +L+++
Sbjct: 120 ---KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ 176
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLSNTPVSNSTMYVAT 1060
E L+Q ++ L+ K LE KL+ + + LE + L Y
Sbjct: 177 VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQL 236
Query: 1061 GSAIVQNQQITDVMKENQKLKKMNAKL 1087
S + Q + ++ +K+K++ A++
Sbjct: 237 QSKVEDEQTLG--LQFQKKIKELQARI 261
>X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 AA)
protein.
Length = 1167
Score = 90.6 bits (215), Expect = 3e-17
Identities = 205/1097 (18%), Positives = 439/1097 (40%), Gaps = 96/1097 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 110 QEKNDLQLQVQAESENLLDAE------ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 163
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ L + I +L E
Sbjct: 164 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 223
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ + + +
Sbjct: 224 KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-EQEKKL---RVDLE-R 278
Query: 207 LKENLIQSLHIGYDNTLSKLN-RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
K L L + ++ L N + D + + C LQS++ ED + L F
Sbjct: 279 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV----EDEQTLGLQFQK 334
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL----------IN 315
L+ +L+E++ K K S+ R L LSE+L I
Sbjct: 335 KIKELQAR----IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 390
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSL------DVFEI--LMDNI----------IN 357
K+ + + +D A L E +L V E+ +DN+ +
Sbjct: 391 LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 450
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
++++++D++ V +++ ++L+ + E + + + L QK R+
Sbjct: 451 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 510
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ ++ + +KE+ + + L++ ++ ++ R L+++ A + + +
Sbjct: 511 EAGELSRQLEEKESIVSQ-LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 569
Query: 478 LSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
L R YE E+E K L+ +KA ++T +A + L E KL
Sbjct: 570 LLREQYEEEQEGKAELQRALSKA-----NSEVAQWRTKYET--DAIQRTEELEEAQEKL- 621
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
++ ++ + + ++ K + E ++ E+ N L + K++ N
Sbjct: 622 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD-----KKQRN 676
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
K L + T+ +E+QA ELE S + + EL K+K
Sbjct: 677 FDKVLAEWKTKCEESQA-ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 735
Query: 657 EAKSLLEQ---NLALKEQCEE--KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
E L EQ N + E+ K + + +I + E A +++ L+ Q+ E
Sbjct: 736 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL-ELT 794
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
++ E + K+ E + E LKR+Y V+ ++S+ +A ++ ++ + + + ++E D+
Sbjct: 795 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA--EVRSRNEAIRLK-KKMEGDLN 851
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
+ + D L + + + K ++++ + +
Sbjct: 852 EIE---IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALQTQEDLKEQLAIV-ERRAN 907
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
L+ + + L+ + K + E E +Q Q L K LE + L+
Sbjct: 908 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 967
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKK 950
++ R A+ + A D A + + A +E+ K L +T+++L+++
Sbjct: 968 EVEDASRDARNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1025
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYL 1009
+ + Q A++ K+ ++ E + +ELE + + E ++ + K L + E
Sbjct: 1026 DEAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELT 1079
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
Q EE K + + ++VDKL + + ++Q E ++ T + + + ++
Sbjct: 1080 YQSEEDRKNVLRLQ---DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEE 1136
Query: 1070 ITDVMKENQKLKKMNAK 1086
D+ + ++ K+ AK
Sbjct: 1137 RADIAE--SQVNKLRAK 1151
Score = 78.6 bits (185), Expect = 1e-13
Identities = 186/972 (19%), Positives = 383/972 (39%), Gaps = 90/972 (9%)
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
E E T +E + D L K EL+E+ TL V E ++L +V +N
Sbjct: 74 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTL-------VQEKNDLQLQVQAESENL 126
Query: 176 ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIG---YDNTLSKLNRSISD 232
++C L K + E KI K + + + +E + L ++ S+L + I D
Sbjct: 127 LDAEERCDQLIKAKFQLEAKI--KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 184
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE--LHEPNMTMDLDEKLGENNE 290
+ + ++ E A K L E+ + + + E + ++ ++ +
Sbjct: 185 LELT-----LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ 239
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
E V +++ K L E L ++ ++ K +D ++ D + S+
Sbjct: 240 AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI----- 294
Query: 351 LMDNIINKYQIDLDEILEK----YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
+D +K Q LDE L+K Y ++Q + + + +K+ L +++ E E
Sbjct: 295 -LDLENDKQQ--LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 351
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEI--LTKECLKLSKLK----IDIPRDLDQDLP 460
R + + + S ++ + L+E +T ++L+K + + + RDL++
Sbjct: 352 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 411
Query: 461 AHKKITILF-----DALITQYE----LSRTDYEIEKEK--LRLE----TGTAKAVXXXXX 505
H+ + D++ E L R ++EKEK +LE + + ++V
Sbjct: 412 QHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 471
Query: 506 XXXXXXXXXFDTLEEAHNEVKSLHEELTKL--YKSKVD----ENNANLNLIKILSEEIDA 559
D L EA + + + L++L KS++ E + L + + ++
Sbjct: 472 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 531
Query: 560 LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERS 619
K A + E++ E++NK ++ + L+ + L + E+E +A EL+R+
Sbjct: 532 SKQAFTQQTEELKRQLEEENKAKNALA--HALQSSRHDCDLLREQYEEEQEGKA-ELQRA 588
Query: 620 CQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD 678
+ K + D + +++ +E A+ +C +
Sbjct: 589 LSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVE---AVNAKCASLEKT 645
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAA 738
RL+ ++ E N + L K+ + DK+ E +TK E + EA ++ +
Sbjct: 646 KQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL 705
Query: 739 VKDLESSREAVNQLTTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXX 796
+L + A + Q + V+ LE +I TEQ A
Sbjct: 706 STELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 765
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
E + + +++ I + S++ ++ +E++ LK Y+ +
Sbjct: 766 ADIQLALEEAEAA--LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVE 823
Query: 857 ECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQ----IRTQQPVERQAK---- 904
++ + + RLKK + +E Q+S+ Q ++ + V+ Q K
Sbjct: 824 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 883
Query: 905 FADVAVNTDEDWANLHSVVVDRMS-YDAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQK 962
D A+ T ED ++V R + AEVE+ + ++ E R +Q+L ++ ++Q
Sbjct: 884 HLDDALQTQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 943
Query: 963 AMEK-----YTKKDKEFEAK--RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
+ +TKK E + + E+ED + +++ K+ + AE LK+ ++
Sbjct: 944 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1003
Query: 1016 CKRLKEAKIALE 1027
L+ K LE
Sbjct: 1004 SAHLERMKKNLE 1015
Score = 72.9 bits (171), Expect = 6e-12
Identities = 186/894 (20%), Positives = 351/894 (39%), Gaps = 96/894 (10%)
Query: 245 LQSELDAGRE---DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV--- 298
LQ ++ A E D +E C+ K LE +T +++ N E K K+
Sbjct: 115 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 174
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--II 356
SE+K++++ L L E +K H K + L E + ++ + +
Sbjct: 175 CSELKKDIDDLELTLAKVEKEK---HATENK---VKNLTEELSGLDETIAKLTREKKALQ 228
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+Q LD++ + KV LN+ S+L+ E L S Q EK+ ++ R +++
Sbjct: 229 EAHQQALDDLQAEEDKVNS-LNKTKSKLEQQVEDLESSLEQ--EKKLRVDLERNKRKLEG 285
Query: 417 EISSAVT--IDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD---- 470
++ A +D+ + +L E L K+ + +L+ + + L KKI L
Sbjct: 286 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 345
Query: 471 ---------ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
A + E R+DY E E+L A V F L
Sbjct: 346 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 405
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
E HE + + K ++ A L E+ID L+ K E++ SE ++
Sbjct: 406 LEEATLQHEAMVATLRKKHADSVAELG------EQIDNLQRVKQKLEKEK---SEFKLEI 456
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
+L S++ + + +L+ I R E Q SE + I+++ EL K+ +
Sbjct: 457 DDLSSSMESVSKSKANLEK----ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEA 512
Query: 642 XXXXXXXXXXXXXXDEA----KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ ++ +Q LK Q EE+ + + L +++ ++
Sbjct: 513 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 572
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ-LTTQK 756
Q+ E + + +++ + KYE D ++LE ++E + Q L +
Sbjct: 573 EQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEAQEKLAQRLQDSE 629
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLD 815
+ VE A+ S +T+Q + ++ L E K +
Sbjct: 630 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 689
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+S ++ E S + R LS EL LK Y+E D+ ET +
Sbjct: 690 ESQ-------AELEASLKESRSLST--ELFKLKNAYEEALDQLET--------------V 726
Query: 876 KKEKLSLEQQVSNLKEQI----RTQQPVERQAK-----FADVAVNTDEDWANLHSVVVDR 926
K+E +LEQ++++L EQI +T +E+ K AD+ + +E A L
Sbjct: 727 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 786
Query: 927 MSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ E+ E ++++ + EE+ K++ + TV MQ A++ + E +K++
Sbjct: 787 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 846
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALE 1040
E +L E++ + + + ++L+ + Q K + AL+ + L Q +E
Sbjct: 847 E---GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALQTQEDLKEQLAIVE 903
Query: 1041 KQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
++ L + +T+ + + Q++ D + Q L N LI KK
Sbjct: 904 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK 957
Score = 52.4 bits (120), Expect = 9e-06
Identities = 61/284 (21%), Positives = 126/284 (44%), Gaps = 29/284 (10%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--------------AEYLQER 868
S ++ E++ +KE + EL + + KEL+++ T +E L +
Sbjct: 70 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 129
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K LE ++ + E R + E A+ +++ + L + D
Sbjct: 130 EERCDQLIKAKFQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 187
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
A+VEK K + K ++L ++ + + + K T++ K EA ++ L+D +AE
Sbjct: 188 TLAKVEKEKHATEN------KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 241
Query: 988 ---LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQI 1043
+ L + +L+++ E L+Q ++ L+ K LE KL+ + + LE
Sbjct: 242 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 301
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ L Y S + Q + ++ +K+K++ A++
Sbjct: 302 QQLDERLKKKDFEYCQLQSKVEDEQTLG--LQFQKKIKELQARI 343
Score = 50.0 bits (114), Expect = 5e-05
Identities = 56/259 (21%), Positives = 107/259 (41%), Gaps = 14/259 (5%)
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
++E+ +KE +++ DE +E +E+ L +EK L+ QV E + + E
Sbjct: 74 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE--E 131
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + + D +AE+ K ++L EL+ DL+ T+ K
Sbjct: 132 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 191
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++K EK+ ++K + +EL + +L + K L E + + L+ E++ L
Sbjct: 192 VEK--EKHATENK-VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSL 248
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQ 1078
+ K KL Q LE +E V G + + I D+ + Q
Sbjct: 249 NKTK------SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 302
Query: 1079 KL-KKMNAKLITICKKRGK 1096
+L +++ K C+ + K
Sbjct: 303 QLDERLKKKDFEYCQLQSK 321
Score = 41.5 bits (93), Expect = 0.016
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ +K + + EAKRKELE+ +L L Q +L + + +E
Sbjct: 69 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEE---KLVTLVQEKNDLQLQVQAESEN 125
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C +L +AK LE K ++ E++I +
Sbjct: 126 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINA 162
Score = 33.9 bits (74), Expect = 3.2
Identities = 23/87 (26%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K + +KE ++E + K EL + + + KEL+E+ T + + Q + E
Sbjct: 65 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESE 124
Query: 1022 AKI-ALEIVDKLSNQKVALEKQIESLS 1047
+ A E D+L K LE +I+ ++
Sbjct: 125 NLLDAEERCDQLIKAKFQLEAKIKEVT 151
>BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 90.6 bits (215), Expect = 3e-17
Identities = 168/888 (18%), Positives = 372/888 (41%), Gaps = 64/888 (7%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
+L++ E+ +E + + K ++ H ++ LDE+ G + + + V ++IK+
Sbjct: 926 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEE 985
Query: 308 S--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL----DVFEILMDNI---INK 358
L E + K+ K DR + + + E +L + E+++ ++ + K
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1045
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN--ILRIQKERIH 416
+ E+ + K+ G+ + ++ + ++ L QL +KE + R E +H
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105
Query: 417 EISS-AVTIDIVKKENELKEILTKECLKLSKLKID-IPRDLDQDLPAHK-KITILFDALI 473
+ ++ V ++ + EL+E E K S+ K + RDL ++L A K ++ D
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESE--KASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 474 TQYEL-SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL 532
Q EL ++ + E+ + K LE T K + L E + K L
Sbjct: 1164 AQQELRTKREQEVAELKKALEEET-KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 533 TKLYKSKVDENNANLNLIKILSE--------------EIDALKIAIAKNEEKMLSLSEKD 578
K + +N +K+L + ++ L +++ + + L+EK
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
+KL + ++ L EE K + ++ + S+L+ + +++++ + + + I
Sbjct: 1283 SKLQNELDNVSTLLEEAEK-KGIK--FAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ K+L +Q LAL+ Q + + +++ ++ T E E + +
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK---KVDDDLGTIESLEEAKKK 1396
Query: 699 MIM---RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLESSREAVNQL 752
++ L ++++E + + E N L + + L D D +LE ++ +QL
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++ + R AE E D R E A F +N+ L +
Sbjct: 1457 LAEEKSISARYAE-ERD-RAEAEAR-EKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--AEYLQERDE 870
+ S K + V +L++ + +Q++++++ + +EL+DE + A+ E +
Sbjct: 1514 EDLMSSKDDVG----KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 871 QCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
Q + + E+ L + + K+++ +Q E +A+ D A+ + +D
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 930 DAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKA---MEKYTKKDKEFEAKRKELE--- 982
+A++E NK + I++LR + +K+ ++++A ++ + KE E K K LE
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 983 -DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+ EL ++ + ++E + A+ + L + K LE +++ E+
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKL 1087
L N +T+ V T +A + ++ +N Q+L++ N +L
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Score = 89.4 bits (212), Expect = 6e-17
Identities = 198/1010 (19%), Positives = 401/1010 (39%), Gaps = 68/1010 (6%)
Query: 64 KESSNEI-NLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS----LEME 118
+E N+I + +K+ + D++EQ EG Q L LE T + + +++ LE +
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 119 NLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLI-MENVTESD---NLNKEV---DDL 171
N KE K + D + S ++ E +E+ L+ + + V SD L KE +L
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
+K L + DL+ + E + +I + K +E L +L G D TL K N
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKL-QLAKKEEELQGALARGDDETLHKNNALKV 1112
Query: 232 DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEF 291
+ I LQ + ++ + + + + LE + + LD + E
Sbjct: 1113 VRELQAQ---IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ-EL 1168
Query: 292 ETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL 351
TK + ++E+K+ +L E+ N+E++ +D R+ +L + + F+
Sbjct: 1169 RTKREQEVAELKK---ALEEETKNHEAQ-IQDMRQRHATALEELSEQ---LEQAKRFKAN 1221
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
++ NK ++ D E +V+ L + +E + +KL + +L K + + LR++
Sbjct: 1222 LEK--NKQGLETDN-KELACEVKV-LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE 1277
Query: 412 -KERIHEISSAV-TIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
E+ ++ + + + + +E E K I K+ L D L ++ ++
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337
Query: 469 FDALITQYELSRTDYEIEKE---KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
L + + E E+E L + ++ ++LEEA ++
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
E L++ + K + L +E D L + + + +L +K K +L+
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+ + + + REKET+A L R+ + + E ++ +
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
E L + AL++Q EE LE ++ E A+++ + M+ K
Sbjct: 1518 SSKDDVGKNVHE---LEKSKRALEQQVEEMRTQLEELEDELQATED-AKLRLEVNMQAMK 1573
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAE 765
E D ++ + NE K L + +LE R+ K +E + +
Sbjct: 1574 AQFERD---LQTRDEQNE--EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI 825
LE+ I A D R+L E + + S
Sbjct: 1629 LEAQIEAANKAR----------DEVIKQLRKLQAQMKDYQREL-EEARASRDEIFAQSKE 1677
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
S+ ++ L+ +L Q+EL + + + E + A+ + + L EK LE +
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEAR 1737
Query: 886 VSNLKEQIRTQQPVER--QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
++ L+E++ +Q +F + D A L +R + ++L +
Sbjct: 1738 IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL---AAERSAAQKSDNARQQLERQN 1794
Query: 944 EELRYKKQDLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDCKAEL----EELKQR 994
+EL+ K Q+L+ V KA K + +++ E + KE + ++LK+
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI 1854
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+ ++++E +Y +Q E+ R+K+ K LE ++ + + A ++++
Sbjct: 1855 FMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Score = 86.6 bits (205), Expect = 4e-16
Identities = 165/848 (19%), Positives = 345/848 (40%), Gaps = 57/848 (6%)
Query: 263 FTSIKNHLELHEPNMTMDL-DEKLGENNEFETKAVKVMSEIKRN-------LNSLSEQL- 313
FT +K L++ + DE+L + E +TK + E++R N L+EQL
Sbjct: 838 FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897
Query: 314 ----INNESKKSKDHIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
+ E+++ + + K L +L D E + ++ N K Q + ++ E
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQ--LIEKENACNIL--RIQKERIHEISSAVTI 424
+ + +G + E + K+ + + L+E +N+ I ++ ++RI E SS +
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ K +N L +I K+ + +S L+ + ++ ++ +K D T + + +
Sbjct: 1018 EEEKAKN-LAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQDQIAELQ 1075
Query: 485 IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
+ ++L+L+ + + + E+++ EL + ++S+ N
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN 1135
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN-GLKEENNSLKSLND 603
+ LSEE++ALK + + + E K + V+ + L+EE + ++
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195
Query: 604 VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
+ + T EL + K+ L+K K + E++ +
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1255
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE 723
+ A ++ K + RL + + EK +++QN + D + T L E
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELA--EKASKLQNEL-----------DNV----STLLEE 1298
Query: 724 LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRT-EQTATVXXXX 782
K +D + L+ ++E + + T QK + RI +LE + + ++
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
T + DLG L+++ K+ ++ D+E L +RL
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK---LLKDAEA--LSQRLEEKAL 1413
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
D L++ L E + L + + + L+K++ +Q ++ K I + ER
Sbjct: 1414 AYDKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS-ISARYAEERD 1472
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQ 961
A+ A + +L + + + E E+ NK+L +E+L K D+ V +++
Sbjct: 1473 RAEAE-AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 962 KAMEKYTKKDKEFEAKRKEL-------EDCKAELEELKQRYK-ELDEECETCAEYLKQRE 1013
K+ ++ +E + +EL ED K LE Q K + + + +T E ++++
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 1014 E-QCKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTMYVATGSAIVQNQQIT 1071
K+++E + LE K VA +K++E L + A I Q +++
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 1072 DVMKENQK 1079
MK+ Q+
Sbjct: 1652 AQMKDYQR 1659
Score = 52.4 bits (120), Expect = 9e-06
Identities = 168/901 (18%), Positives = 354/901 (39%), Gaps = 84/901 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL--QDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
+L GA ++ D+ ++N +K+ + I + +S K S N+ + LS EL
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 84 IK-EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+K E + L+ L T+ + K+LE E TK+ E + + D + + + E
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--TKNHEAQ-IQDMRQRHATALEE 1207
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L E+ + NL K L+ +N+ L + L+++ ESE+K K +
Sbjct: 1208 LSEQLEQAKRF-------KANLEKNKQGLETDNKELACEVKVLQQVKAESEHK--RKKLD 1258
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCED 262
AQ +Q LH +L +++ S N++ + + L+ + + +D
Sbjct: 1259 AQ-------VQELHAKVSEG-DRLRVELAEK-ASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 263 FTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
S+++ L+ D E L E + + +++ NSL EQ E ++++
Sbjct: 1310 AASLESQLQ--------DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ--QEEEEEAR 1359
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTS 382
++++ +LA L ++ T V D+ + + L+E +K K L++
Sbjct: 1360 KNLEK---QVLA-LQSQLADTKKKV-----DDDLGTIE-SLEEAKKKLLKDAEALSQRLE 1409
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
E +KL ++L ++ + L + + +++S ++ KK+ + ++L +E
Sbjct: 1410 EKALAYDKLEKTKNRLQQEPDD---LTVDLDHQRQVAS----NLEKKQKKFDQLLAEE-- 1460
Query: 443 KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL-SRTDYEIEKEKLRLETGTAKAVX 501
K + RD + K+ L A + L ++ ++E + ++LR + +
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520
Query: 502 XXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDEN-NANLNLIKILSEEIDAL 560
LE+ E+++ EEL ++ D +N+ + ++ L
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
Query: 561 KIAIAKNEEKMLSL--------SEKDNKLTELVSTINGLKEENNSLKSLN---DVITREK 609
+ +NEEK L +E +++ + + K+ LK L + + +
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 610 ETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL-LEQNLAL 668
+ +L + +K EL++ +A EA+ L L++ LA
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARAS--RDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 669 KEQCE---EKTRDCSRLEINIKTHEKTAEIQNRM-----IMRLQKQIQEDDKLFIEKETK 720
E+ E+ RD EI K+A + + I +L+++++E+ +
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+ T + + L + A + S A QL Q ++ ++ ELE ++++ AT+
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLL 838
N+ + K K + D Q KE++
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAA--NKLVRRTEK---KLKEIFMQVEDERRHADQYKEQME 1873
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
+ LK + +E ++E ++ + + L ++VS LK ++R P
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP 1933
Query: 899 V 899
+
Sbjct: 1934 I 1934
>X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy chain
(1085 AA) protein.
Length = 1085
Score = 90.2 bits (214), Expect = 4e-17
Identities = 208/1101 (18%), Positives = 431/1101 (39%), Gaps = 104/1101 (9%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 28 QEKNDLQLQVQAESENLLDAE------ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 81
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ L + I +L E
Sbjct: 82 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 141
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ + + +
Sbjct: 142 KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-EQEKKL---RVDLE-R 196
Query: 207 LKENLIQSLHIGYDNTLSKLN-RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
K L L + ++ L N + D + + C LQS++ ED + L F
Sbjct: 197 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV----EDEQTLGLQFQK 252
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL----------IN 315
L+ +L+E++ K K S+ R L LSE+L I
Sbjct: 253 KIKELQAR----IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 308
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSL------DVFEI--LMDNI----------IN 357
K+ + + +D A L E +L V E+ +DN+ +
Sbjct: 309 LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 368
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
++++++D++ V +++ ++L+ + E + + + L QK R+
Sbjct: 369 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 428
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ ++ + +KE+ + + L++ ++ ++ R L+++ A + + +
Sbjct: 429 EAGELSRQLEEKESIVSQ-LSRSKQAFTQQTEELKRQLEEENKAKNALGHALQSSRHDCD 487
Query: 478 LSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
L R YE E+E K L+ +KA EE EE K
Sbjct: 488 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL--------EEAKKKL 539
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
++ ++ + + ++ K + E ++ E+ N L + K++ N
Sbjct: 540 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD-----KKQRN 594
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
K L + T+ +E+QA ELE S + + EL K+K
Sbjct: 595 FDKVLAEWKTKCEESQA-ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 653
Query: 657 EAKSLLEQ---NLALKEQCEE--KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
E L EQ N + E+ K + + +I + E A +++ L+ Q+ E
Sbjct: 654 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL-ELT 712
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA----VNQLTTQKDLVEGRIAELE 767
++ E + K+ E + E LKR+Y V+ ++S+ +A N+ K +EG + E+E
Sbjct: 713 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDLNEIE 772
Query: 768 SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+ D L + + + K ++++ +
Sbjct: 773 ----------IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV-E 821
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+ L+ + + L+ + K + E E +Q Q L K LE +
Sbjct: 822 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM 881
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEEL 946
L+ ++ R A+ + A D A + + A +E+ K L +T+++L
Sbjct: 882 QLQSEVEDASRDARNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 939
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETC 1005
+++ + + Q A++ K+ ++ E + +ELE + + E ++ + K L +
Sbjct: 940 QHRLDEAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRV 993
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
E Q EE K + + ++VDKL + + ++Q E ++ T + +
Sbjct: 994 KELTYQSEEDRKNVLRLQ---DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1050
Query: 1066 QNQQITDVMKENQKLKKMNAK 1086
+ ++ D+ + ++ K+ AK
Sbjct: 1051 EAEERADIAE--SQVNKLRAK 1069
Score = 75.8 bits (178), Expect = 8e-13
Identities = 189/993 (19%), Positives = 384/993 (38%), Gaps = 98/993 (9%)
Query: 73 KLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE-IKNLTD 131
+ +K EL + ++ LE K L+ Q ++ L Q+++ E ENL +E L
Sbjct: 1 EFQKTKDELAKSEAKRKELEEKLVTLV---QEKNDLQLQVQA-ESENLLDAEERCDQLIK 56
Query: 132 SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE 191
+ KI E+ E + + E + L E +LKK+ + L +EK +
Sbjct: 57 AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 116
Query: 192 SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDA 251
+ENK+ +NL + L G D T++KL R + + LQ+E D
Sbjct: 117 TENKV------------KNLTEELS-GLDETIAKLTRE-KKALQEAHQQALDDLQAEEDK 162
Query: 252 GREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
K+ LE DL+ L + + + +++ +L E
Sbjct: 163 --------VNSLNKTKSKLE----QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 210
Query: 312 QLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYT 371
+++ E+ K + +R K + + I + Q ++E+ E+
Sbjct: 211 SILDLENDKQQLD-ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 269
Query: 372 KVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN 431
+ + + +L L+ +L E A + Q E ++ + +K
Sbjct: 270 AERATRAKTEKQRSDYARELEELSERL---EEAGGVTSTQIE----LNKKREAEFLKLRR 322
Query: 432 ELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR 491
+L+E + ++ L+ + D ++I L + + E ++++++E + L
Sbjct: 323 DLEEATLQHEAMVATLR---KKHADSVAELGEQIDNL-QRVKQKLEKEKSEFKLEIDDL- 377
Query: 492 LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL--YKSKVD----ENNA 545
+ + ++V D L EA + + + L++L KS++ E +
Sbjct: 378 --SSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 435
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
L + + ++ K A + E++ E++NK + + L+ + L +
Sbjct: 436 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALG--HALQSSRHDCDLLREQY 493
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
E+E +A EL+R+ L K +++ +EAK L Q
Sbjct: 494 EEEQEGKA-ELQRA----------LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 542
Query: 666 LA-LKEQCEEKTRDCSRLE-----INIKTHEKTAEIQ--NRMIMRLQKQIQEDDKLFIEK 717
L +EQ E C+ LE + + + +++ N + L K+ + DK+ E
Sbjct: 543 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 602
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR--TEQT 775
+TK E + EA ++ + +L + A + Q + V+ LE +I TEQ
Sbjct: 603 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 662
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
A E + + +++ I + S++
Sbjct: 663 AENGKTIHELEKSRKQIELEKADIQLALEEAEAA--LEHEEAKILRIQLELTQVKSEIDR 720
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKE 891
++ +E++ LK Y+ + ++ + R + RLKK + +E Q+S+
Sbjct: 721 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDLNEIEIQLSHANR 780
Query: 892 Q----IRTQQPVERQAK----FADVAVNTDEDWANLHSVVVDRMS-YDAEVEKNKRLMKT 942
Q ++ + V+ Q K D A+ ED ++V R + AEVE+ + ++
Sbjct: 781 QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 840
Query: 943 IEELR-YKKQDLKNTVTKMQKAMEK-----YTKKDKEFEAK--RKELEDCKAELEELKQR 994
E R +Q+L ++ ++Q + +TKK E + + E+ED + +++
Sbjct: 841 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 900
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
K+ + AE LK+ ++ L+ K LE
Sbjct: 901 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 933
Score = 70.1 bits (164), Expect = 4e-11
Identities = 185/894 (20%), Positives = 351/894 (39%), Gaps = 96/894 (10%)
Query: 245 LQSELDAGRE---DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV--- 298
LQ ++ A E D +E C+ K LE +T +++ N E K K+
Sbjct: 33 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 92
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--II 356
SE+K++++ L L E +K H K + L E + ++ + +
Sbjct: 93 CSELKKDIDDLELTLAKVEKEK---HATENK---VKNLTEELSGLDETIAKLTREKKALQ 146
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+Q LD++ + KV LN+ S+L+ E L S Q EK+ ++ R +++
Sbjct: 147 EAHQQALDDLQAEEDKVNS-LNKTKSKLEQQVEDLESSLEQ--EKKLRVDLERNKRKLEG 203
Query: 417 EISSAVT--IDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD---- 470
++ A +D+ + +L E L K+ + +L+ + + L KKI L
Sbjct: 204 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 263
Query: 471 ---------ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
A + E R+DY E E+L A V F L
Sbjct: 264 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 323
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
E HE + + K ++ A L E+ID L+ K E++ SE ++
Sbjct: 324 LEEATLQHEAMVATLRKKHADSVAELG------EQIDNLQRVKQKLEKEK---SEFKLEI 374
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
+L S++ + + +L+ I R E Q SE + I+++ EL K+ +
Sbjct: 375 DDLSSSMESVSKSKANLEK----ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEA 430
Query: 642 XXXXXXXXXXXXXXDEA----KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ ++ +Q LK Q EE+ + + L +++ ++
Sbjct: 431 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALGHALQSSRHDCDLLR 490
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ-LTTQK 756
Q+ E + + +++ + KYE D ++LE +++ + Q L +
Sbjct: 491 EQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEAKKKLAQRLQDSE 547
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLD 815
+ VE A+ S +T+Q + ++ L E K +
Sbjct: 548 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 607
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+S ++ E S + R LS EL LK Y+E D+ ET +
Sbjct: 608 ESQ-------AELEASLKESRSLST--ELFKLKNAYEEALDQLET--------------V 644
Query: 876 KKEKLSLEQQVSNLKEQI----RTQQPVERQAK-----FADVAVNTDEDWANLHSVVVDR 926
K+E +LEQ++++L EQI +T +E+ K AD+ + +E A L
Sbjct: 645 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 704
Query: 927 MSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ E+ E ++++ + EE+ K++ + TV MQ A++ ++ E +K++
Sbjct: 705 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKM 764
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALE 1040
E +L E++ + + + ++L+ + Q K + AL + L Q +E
Sbjct: 765 E---GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 821
Query: 1041 KQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
++ L + +T+ + + Q++ D + Q L N LI KK
Sbjct: 822 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK 875
Score = 57.2 bits (132), Expect = 3e-07
Identities = 61/267 (22%), Positives = 126/267 (47%), Gaps = 22/267 (8%)
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
S+++ +L+E+L++ QE +DL +L + E +E L + +E+C +L K K LE +
Sbjct: 12 SEAKRKELEEKLVTLVQEKNDL-----QLQVQAE--SENLLDAEERCDQLIKAKFQLEAK 64
Query: 886 VSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEE 945
+ + E R + E A+ +++ + L + D A+VEK K +
Sbjct: 65 IKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN--- 119
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE---LEELKQRYKELDEE 1001
K ++L ++ + + + K T++ K EA ++ L+D +AE + L + +L+++
Sbjct: 120 ---KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ 176
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQIESLSNTPVSNSTMYVAT 1060
E L+Q ++ L+ K LE KL+ + + LE + L Y
Sbjct: 177 VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQL 236
Query: 1061 GSAIVQNQQITDVMKENQKLKKMNAKL 1087
S + Q + ++ +K+K++ A++
Sbjct: 237 QSKVEDEQTLG--LQFQKKIKELQARI 261
>AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein.
Length = 1583
Score = 90.2 bits (214), Expect = 4e-17
Identities = 229/1058 (21%), Positives = 429/1058 (40%), Gaps = 115/1058 (10%)
Query: 33 KNDNIIETQSNPIK-LQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF-DIKEQKSA 90
KN N ++ + +K + + C++ S KE EIN KL +L L + +
Sbjct: 131 KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN-KLNELKENLVKQCEASEKN 189
Query: 91 LEGKYQ----NLILETQTRDLLMSQIKSLEMENLT-----KDKEIKNLTDSLKTKSKKIN 141
++ KY+ NL T + +QI S+ ++ T ++++K+L D+LK + +
Sbjct: 190 IQKKYECELENLRKATSNANQ-DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 248
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEV----DDLK-KNNECLTQK----CIDLEKLVNES 192
L++E ++NL ++ ++ ++ E +DL+ K NE L K C+ +EKL +E
Sbjct: 249 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV-IEKLKSEL 307
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS-ISDSNTSTRYNKICTLQSELDA 251
K C + +QSL + +S+LN + +SDS TL E+
Sbjct: 308 AGL--NKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEK-----LTLMFEIQG 360
Query: 252 GREDCKELCEDFT-SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
+E C+ L ++ +I N+ L E + L +LGE+ A K+ E + +
Sbjct: 361 LKEQCENLQQEKQEAILNYESLRE--IMEILQTELGES------AGKISQEFESMKQQQA 412
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
+ + K + KD+LL ++ G + + ++ + + + + EK
Sbjct: 413 SDVHELQQKLRTAFTE--KDALLETVNRLQGENEKLLSQ---QELVPELENTIKNLQEKN 467
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L++ + LK + K+ SL EK++ N L+ E + D K+
Sbjct: 468 GVYLLSLSQRDTMLKELEGKINSLTE---EKDDFINKLKNSHEEM---------DNFHKK 515
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI-TQYELSRTDYEIEKEK 489
E +E L E K + I +L+Q K+ L L T E + D ++EK
Sbjct: 516 CEREERLILELGKKVEQTIQYNSELEQ------KVNELTGGLEETLKEKDQNDQKLEKLM 569
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD----ENNA 545
+++ K + ++ + +E K L +L K D E+
Sbjct: 570 VQM-----KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 624
Query: 546 NLNL-IKILSEEIDAL-KIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLND 603
L ++++ EE D L K+ + +K+ ++ L E+ S ++ EE K + +
Sbjct: 625 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEE----KDVVN 680
Query: 604 VITREKETQASELERSCQVIKQNG---FELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
V+ E+ A E C + Q EL+K + ++ K
Sbjct: 681 VLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV 740
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ---------EDD 711
LL + L + Q E++ LE+ +EKT +++++++ Q E +
Sbjct: 741 LLRKELE-EIQSEKEALQSDLLEMK-NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE 798
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAV-KD-LESSREAVNQ-LTTQKDLVEGRIAELES 768
K FI++ L L + E R + + KD L S N L++ K+L E +I LE
Sbjct: 799 KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEK 857
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
+ + ++ T +E L + R + ++S
Sbjct: 858 ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 917
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+ L E +Q LD KER + E L+ QC + + L ++
Sbjct: 918 YKNLLLEYEKQSEQ-LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 976
Query: 889 LKEQIRTQQ----PVERQAKFADVAVNTD----EDWANLHSVVVDRMS-YDAEVEKNKR- 938
L+ + + V+R D + + E H+ V+ + +++K K+
Sbjct: 977 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQ 1036
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK----RKELEDCKAELEELKQR 994
L KT++EL K+D + T T M + Y + KE K ++ED + E++ KQ+
Sbjct: 1037 LQKTMQELELVKKDAQQT-TLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK 1095
Query: 995 YKELDEECETCAEYLKQREEQCKRLKE--AKIALEIVD 1030
+ L EE + ++Q EE+ ++K+ K E+ D
Sbjct: 1096 QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1133
Score = 81.4 bits (192), Expect = 2e-14
Identities = 184/1055 (17%), Positives = 412/1055 (39%), Gaps = 53/1055 (5%)
Query: 59 MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
M Q +E+ KL E + E + L+G+ + L+ + + L + IK+L+ +
Sbjct: 407 MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEK 466
Query: 119 NLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD-------DL 171
N + LK KIN L EE D N + + E DN +K+ + +L
Sbjct: 467 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 526
Query: 172 KKNNECLTQKCIDLEKLVNE----SENKIGPKNICAQCKLKENLIQSLHIGYD-NTLSKL 226
K E Q +LE+ VNE E + K+ Q KL++ ++Q + D LS
Sbjct: 527 GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ-KLEKLMVQMKVLSEDKEVLSAE 585
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+S+ + N NK+ + + +L E ED +K H+ E + + ++E+
Sbjct: 586 VKSLYEEN-----NKLSSEKKQLSRDLEVFLSQKED-VILKEHITQLEKKLQLMVEEQDN 639
Query: 287 ENNEFETKAVK---VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
N E + V+ V +++ L + ++ + +K ++ + LA ++ E
Sbjct: 640 LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL 699
Query: 344 SL--DVFEILMDNIINKYQ----IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ D + ++ I Q + +E+ + + EL+ + + +L S
Sbjct: 700 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 759
Query: 398 LIEKENACNILRIQKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L+E +NA R++ + ++ E+S + + E E I E LK L+ R
Sbjct: 760 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLK-PLLEQKELR 818
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXX 513
D +L K ++ + LS E+E++ LE K
Sbjct: 819 DRRAELILLKD-SLAKSPSVKNDPLSSVK-ELEEKIENLEK-ECKEKEEKINKIKLVAVK 875
Query: 514 XFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
L+ + E +++ EEL L +S+ D+ +A++ + +E L + K E++
Sbjct: 876 AKKELDSSRKETQTVKEELESL-RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDV 934
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA--SELERSCQVIKQNGFELD 631
E+ N + + ++ NS + + ++ A L+ + ++++ E+
Sbjct: 935 EKERANNFEHRIEDLT--RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 992
Query: 632 KMKADI-LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+ KA + L E + L++Q ++ + LE+ +K
Sbjct: 993 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELEL-VKKDA 1051
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
+ + N I ++ ++E ++ K K+ +L + + K+ + +++ S + +V
Sbjct: 1052 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1111
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL-G 809
Q + ++ + + + ++ + A + + ++
Sbjct: 1112 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1171
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
E K+ + K S +S ++R+ + Q+E K + E E+ + R
Sbjct: 1172 EKHKIHEHLKTSAEQ-HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES----YKVRV 1226
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ +K K + + K++ + + Q K + + + N+ + + +
Sbjct: 1227 HNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI-KLQDSQNNLQINVSELQTLQSEH 1285
Query: 930 DAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
D +E+ NK L +T+ + ++ L + ++ ++T+ + ++ + L + +
Sbjct: 1286 DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN--SFR 1343
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
++++ +E + ET + L + E Q +LK V + K E++ L
Sbjct: 1344 DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPL 1403
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
+ T G + ++ Q L+++
Sbjct: 1404 LDMHTVTREEGEGMETTDTESVSSASTYTQSLEQL 1438
Score = 75.8 bits (178), Expect = 8e-13
Identities = 202/1028 (19%), Positives = 418/1028 (40%), Gaps = 108/1028 (10%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINE--------LQEENDT---LSNLIMENVTES 161
K LE ++ KEI+NL + L K +E L+E +T LS +
Sbjct: 17 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSE 76
Query: 162 DNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN 221
DN+ K ++++K ++ + L+K ++ + ++ K Q +N+I++ Y
Sbjct: 77 DNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDE--KKETVTQL---QNIIEANSQHYQK 131
Query: 222 TLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL----ELHEPNM 277
++ L + + ++ L +++A ++ + +K +L E E N+
Sbjct: 132 NINSLQEELLQLK-AIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNI 190
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNL---NSLSEQLINNESKKSKDHIDRYKDSLLA 334
+ +L EN T ++I L N+ EQ++N + K +D + +
Sbjct: 191 QKKYECEL-ENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSI 249
Query: 335 VLDAEFGTTSLDV-FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
+ D +L + E+ +I +++ + +++ K ++ E ++ + +LA
Sbjct: 250 LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 309
Query: 394 LNSQL---IEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID 450
LN Q +E+ N + ++++ EIS + E E K L E L + +
Sbjct: 310 LNKQFCYTVEQHNR-EVQSLKEQHQKEISELNETFLSDSEKE-KLTLMFEIQGLKEQCEN 367
Query: 451 IPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXX 510
+ ++ + + ++ + + + I Q EL + +I +E ++ A V
Sbjct: 368 LQQEKQEAILNYESLREIME--ILQTELGESAGKISQEFESMKQQQASDVHELQ------ 419
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
L A E +L E + +L EN L+ +++ E + +K KN
Sbjct: 420 -----QKLRTAFTEKDALLETVNRLQ----GENEKLLSQQELVPELENTIKNLQEKNGVY 470
Query: 571 MLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFEL 630
+LSLS++D L EL IN L EE + +N + + + + C+ ++ EL
Sbjct: 471 LLSLSQRDTMLKELEGKINSLTEEKDDF--INKL--KNSHEEMDNFHKKCEREERLILEL 526
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
K + +E +QN E+ + + S + +
Sbjct: 527 GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 586
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFI-EKE-----TKLNELTNKYEALKRDYDAAVKDLES 744
K+ +N + +KQ+ D ++F+ +KE + +L K + + + D K LE+
Sbjct: 587 KSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLEN 646
Query: 745 SREAVNQLTTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E V +L + L G + E+ S++ +E+ V
Sbjct: 647 --EQVQKLFVKTQLY-GFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQR 703
Query: 803 DEN--------RDLGENPKLDDSPKRSI-------SVISDSEVSQLKERLLSCQQELDDL 847
DE + L E + +S+ V+ E+ +++ + Q +L ++
Sbjct: 704 DEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEM 763
Query: 848 KERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQQVSNLKEQIRTQQPVERQA 903
K ++ E + ++E + C++ +KEK +++ NLK + ++ +R+A
Sbjct: 764 KNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEH-ENLKPLLEQKELRDRRA 822
Query: 904 KFADVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTKMQK 962
+ + + A SV D +S E+ EK + L K +E K +K K +K
Sbjct: 823 EL----ILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKK 878
Query: 963 AMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA 1022
++ KE + ++ELE ++E ++L ++L + E+ L + E+Q ++L
Sbjct: 879 ELD---SSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE 935
Query: 1023 KIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
K ++ +N E +IE L+ + NST+ T N D++ + L+
Sbjct: 936 K------ERANN----FEHRIEDLTR-QLRNSTLQCET-----INSDNEDLLARIETLQS 979
Query: 1083 MNAKLITI 1090
NAKL+ +
Sbjct: 980 -NAKLLEV 986
Score = 68.5 bits (160), Expect = 1e-10
Identities = 153/741 (20%), Positives = 311/741 (41%), Gaps = 63/741 (8%)
Query: 37 IIETQSNPIKLQDSGTIT---ISCKMCQSLKESSNEINLKLEK--LSGELFDIKEQKSAL 91
++E Q N KL ++ + + ++ LKE +E++ E+ + L + E + +
Sbjct: 633 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 692
Query: 92 EGKYQNLILETQTRDL-LMSQIKSLEMENLTKDKEIKNLTDSLKTKS----KKINELQEE 146
+ NL + + L L +IK L+ E++ + +E+K+L + + K++ E+Q E
Sbjct: 693 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 752
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
+ L + ++E ++ E +L E ++Q C E + NE E ++ +
Sbjct: 753 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE-IHNEKEKCFIKEHENLKPL 811
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSI 266
L++ ++ + L K + + S S + + + L+ +++ ++CKE E I
Sbjct: 812 LEQKELRDRRA--ELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI 869
Query: 267 KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID 326
K L + +D K ET+ VK E +L S +QL S +D I
Sbjct: 870 K--LVAVKAKKELDSSRK-------ETQTVK---EELESLRSEKDQL----SASMRDLIQ 913
Query: 327 RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS 386
+ +L+ E + LDV + +N ++ + DL L T +N +L +
Sbjct: 914 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIE-DLTRQLRNSTLQCETINSDNEDLLA 972
Query: 387 VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILT-----KEC 441
E L S N++L+E + IL +Q+ + + + + ++KE ++KE T +E
Sbjct: 973 RIETLQS-NAKLLEVQ----ILEVQRAKAM-VDKELEAEKLQKEQKIKEHATTVNELEEL 1026
Query: 442 -LKLSKLKIDIPRDLDQDLPAHKKI---TILFDALITQYE-----LSR--TDYEIEKEKL 490
++L K K + + + Q+L KK T L + I YE L++ T+ + E L
Sbjct: 1027 QVQLQKQKKQLQKTM-QELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDL 1085
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
E K EE + ++K L + K +L L
Sbjct: 1086 EQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ 1145
Query: 551 KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR-EK 609
L E++A + + + ++ ++ + +K+ E + T ++ +L + +T ++
Sbjct: 1146 ASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT--SAEQHQRTLSAYQQRVTALQE 1203
Query: 610 ETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK 669
E +A++ E Q + FE K++ ++ + + LE L
Sbjct: 1204 ECRAAKAE---QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEM---LI 1257
Query: 670 EQCEEKTRDC-SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
+Q + K +D + L+IN+ + + ++ R K +QE E KL + ++
Sbjct: 1258 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN 1317
Query: 729 EALKRDYDAAVKDLESSREAV 749
+K ++ V L S E +
Sbjct: 1318 MMMKSEHTQTVSQLTSQNEVL 1338
>AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein.
Length = 1635
Score = 90.2 bits (214), Expect = 4e-17
Identities = 229/1058 (21%), Positives = 429/1058 (40%), Gaps = 115/1058 (10%)
Query: 33 KNDNIIETQSNPIK-LQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF-DIKEQKSA 90
KN N ++ + +K + + C++ S KE EIN KL +L L + +
Sbjct: 183 KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN-KLNELKENLVKQCEASEKN 241
Query: 91 LEGKYQ----NLILETQTRDLLMSQIKSLEMENLT-----KDKEIKNLTDSLKTKSKKIN 141
++ KY+ NL T + +QI S+ ++ T ++++K+L D+LK + +
Sbjct: 242 IQKKYECELENLRKATSNANQ-DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 300
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEV----DDLK-KNNECLTQK----CIDLEKLVNES 192
L++E ++NL ++ ++ ++ E +DL+ K NE L K C+ +EKL +E
Sbjct: 301 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV-IEKLKSEL 359
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS-ISDSNTSTRYNKICTLQSELDA 251
K C + +QSL + +S+LN + +SDS TL E+
Sbjct: 360 AGL--NKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEK-----LTLMFEIQG 412
Query: 252 GREDCKELCEDFT-SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
+E C+ L ++ +I N+ L E + L +LGE+ A K+ E + +
Sbjct: 413 LKEQCENLQQEKQEAILNYESLRE--IMEILQTELGES------AGKISQEFESMKQQQA 464
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
+ + K + KD+LL ++ G + + ++ + + + + EK
Sbjct: 465 SDVHELQQKLRTAFTE--KDALLETVNRLQGENEKLLSQ---QELVPELENTIKNLQEKN 519
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L++ + LK + K+ SL EK++ N L+ E + D K+
Sbjct: 520 GVYLLSLSQRDTMLKELEGKINSLTE---EKDDFINKLKNSHEEM---------DNFHKK 567
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI-TQYELSRTDYEIEKEK 489
E +E L E K + I +L+Q K+ L L T E + D ++EK
Sbjct: 568 CEREERLILELGKKVEQTIQYNSELEQ------KVNELTGGLEETLKEKDQNDQKLEKLM 621
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD----ENNA 545
+++ K + ++ + +E K L +L K D E+
Sbjct: 622 VQM-----KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 676
Query: 546 NLNL-IKILSEEIDAL-KIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLND 603
L ++++ EE D L K+ + +K+ ++ L E+ S ++ EE K + +
Sbjct: 677 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEE----KDVVN 732
Query: 604 VITREKETQASELERSCQVIKQNG---FELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
V+ E+ A E C + Q EL+K + ++ K
Sbjct: 733 VLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV 792
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ---------EDD 711
LL + L + Q E++ LE+ +EKT +++++++ Q E +
Sbjct: 793 LLRKELE-EIQSEKEALQSDLLEMK-NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE 850
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAV-KD-LESSREAVNQ-LTTQKDLVEGRIAELES 768
K FI++ L L + E R + + KD L S N L++ K+L E +I LE
Sbjct: 851 KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEE-KIENLEK 909
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
+ + ++ T +E L + R + ++S
Sbjct: 910 ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 969
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+ L E +Q LD KER + E L+ QC + + L ++
Sbjct: 970 YKNLLLEYEKQSEQ-LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1028
Query: 889 LKEQIRTQQ----PVERQAKFADVAVNTD----EDWANLHSVVVDRMS-YDAEVEKNKR- 938
L+ + + V+R D + + E H+ V+ + +++K K+
Sbjct: 1029 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1088
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK----RKELEDCKAELEELKQR 994
L KT++EL K+D + T T M + Y + KE K ++ED + E++ KQ+
Sbjct: 1089 LQKTMQELELVKKDAQQT-TLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK 1147
Query: 995 YKELDEECETCAEYLKQREEQCKRLKE--AKIALEIVD 1030
+ L EE + ++Q EE+ ++K+ K E+ D
Sbjct: 1148 QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELAD 1185
Score = 80.2 bits (189), Expect = 4e-14
Identities = 183/1055 (17%), Positives = 412/1055 (39%), Gaps = 53/1055 (5%)
Query: 59 MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
M Q +E+ KL E + E + L+G+ + L+ + + L + IK+L+ +
Sbjct: 459 MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEK 518
Query: 119 NLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD-------DL 171
N + LK KIN L EE D N + + E DN +K+ + +L
Sbjct: 519 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 578
Query: 172 KKNNECLTQKCIDLEKLVNE----SENKIGPKNICAQCKLKENLIQSLHIGYD-NTLSKL 226
K E Q +LE+ VNE E + K+ Q KL++ ++Q + D LS
Sbjct: 579 GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ-KLEKLMVQMKVLSEDKEVLSAE 637
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+S+ + N NK+ + + +L E ED +K H+ E + + ++E+
Sbjct: 638 VKSLYEEN-----NKLSSEKKQLSRDLEVFLSQKED-VILKEHITQLEKKLQLMVEEQDN 691
Query: 287 ENNEFETKAVK---VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
N E + V+ V +++ L + ++ + +K ++ + LA ++ E
Sbjct: 692 LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL 751
Query: 344 SL--DVFEILMDNIINKYQ----IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ D + ++ I Q + +E+ + + EL+ + + +L S
Sbjct: 752 AFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 811
Query: 398 LIEKENACNILRIQKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L+E +NA R++ + ++ E+S + + E E I E LK L+ R
Sbjct: 812 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLK-PLLEQKELR 870
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXX 513
D +L K ++ + LS E+E++ LE K
Sbjct: 871 DRRAELILLKD-SLAKSPSVKNDPLSSVK-ELEEKIENLEK-ECKEKEEKINKIKLVAVK 927
Query: 514 XFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
L+ + E +++ EEL L +S+ D+ +A++ + +E L + K E++
Sbjct: 928 AKKELDSSRKETQTVKEELESL-RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDV 986
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA--SELERSCQVIKQNGFELD 631
E+ N + + ++ NS + + ++ A L+ + ++++ E+
Sbjct: 987 EKERANNFEHRIEDLT--RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 1044
Query: 632 KMKADI-LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+ KA + L E + L+++ ++ + LE+ +K
Sbjct: 1045 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL-VKKDA 1103
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
+ + N I ++ ++E ++ K K+ +L + + K+ + +++ S + +V
Sbjct: 1104 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1163
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL-G 809
Q + ++ + + + ++ + A + + ++
Sbjct: 1164 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1223
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
E K+ + K S +S ++R+ + Q+E K + E E+ + R
Sbjct: 1224 EKHKIHEHLKTSAEQ-HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES----YKVRV 1278
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ +K K + + K++ + + Q K + + + N+ + + +
Sbjct: 1279 HNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI-KLQDSQNNLQINVSELQTLQSEH 1337
Query: 930 DAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
D +E+ NK L +T+ + ++ L + ++ ++T+ + ++ + L + +
Sbjct: 1338 DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN--SFR 1395
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
++++ +E + ET + L + E Q +LK V + K E++ L
Sbjct: 1396 DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPL 1455
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
+ T G + ++ Q L+++
Sbjct: 1456 LDMHTVTREEGEGMETTDTESVSSASTYTQSLEQL 1490
Score = 78.6 bits (185), Expect = 1e-13
Identities = 210/1070 (19%), Positives = 436/1070 (40%), Gaps = 112/1070 (10%)
Query: 75 EKLSGELFDIKE-QKSALEGKYQNLILETQTRDLLMSQ---IKSLEMENLTKDKEIKNLT 130
E+L L + E ++ L K +N+ ++ + D + K LE ++ KEI+NL
Sbjct: 27 ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLK 86
Query: 131 DSLKTKSKKINE--------LQEENDT---LSNLIMENVTESDNLNKEVDDLKKNNECLT 179
+ L K +E L+E +T LS + DN+ K ++++K
Sbjct: 87 NELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFE 146
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
++ + L+K ++ + ++ K Q +N+I++ Y ++ L + +
Sbjct: 147 EQILYLQKQLDATTDE--KKETVTQL---QNIIEANSQHYQKNINSLQEELLQLK-AIHQ 200
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHL----ELHEPNMTMDLDEKLGENNEFETKA 295
++ L +++A ++ + +K +L E E N+ + +L EN T
Sbjct: 201 EEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECEL-ENLRKATSN 259
Query: 296 VKVMSEIKRNL---NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV-FEIL 351
++I L N+ EQ++N + K +D + + + D +L + E+
Sbjct: 260 ANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMD 319
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL---IEKENACNIL 408
+I +++ + +++ K ++ E ++ + +LA LN Q +E+ N +
Sbjct: 320 AQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNR-EVQ 378
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
++++ EIS + E E K L E L + ++ ++ + + ++ + +
Sbjct: 379 SLKEQHQKEISELNETFLSDSEKE-KLTLMFEIQGLKEQCENLQQEKQEAILNYESLREI 437
Query: 469 FDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL 528
+ I Q EL + +I +E ++ A V L A E +L
Sbjct: 438 ME--ILQTELGESAGKISQEFESMKQQQASDVHELQ-----------QKLRTAFTEKDAL 484
Query: 529 HEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTI 588
E + +L EN L+ +++ E + +K KN +LSLS++D L EL I
Sbjct: 485 LETVNRLQ----GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI 540
Query: 589 NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXX 648
N L EE + +N + + + + C+ ++ EL K +
Sbjct: 541 NSLTEEKDDF--INKL--KNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKV 596
Query: 649 XXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ 708
+E +QN E+ + + S + + K+ +N + +KQ+
Sbjct: 597 NELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLS 656
Query: 709 EDDKLFI-EKE-----TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
D ++F+ +KE + +L K + + + D K LE+ E V +L + L G
Sbjct: 657 RDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLEN--EQVQKLFVKTQLY-GF 713
Query: 763 IAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDEN--------RDLGENP 812
+ E+ S++ +E+ V DE + L E
Sbjct: 714 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 773
Query: 813 KLDDSPKRSI-------SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
+ +S+ V+ E+ +++ + Q +L ++K ++ E + +
Sbjct: 774 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQV 833
Query: 866 QERDEQCARL----KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
+E + C++ +KEK +++ NLK + ++ +R+A+ + + A S
Sbjct: 834 EEVSQTCSKSEIHNEKEKCFIKEH-ENLKPLLEQKELRDRRAEL----ILLKDSLAKSPS 888
Query: 922 VVVDRMSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
V D +S E+ EK + L K +E K +K K +K ++ KE + ++E
Sbjct: 889 VKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELD---SSRKETQTVKEE 945
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALE 1040
LE ++E ++L ++L + E+ L + E+Q ++L K ++ +N E
Sbjct: 946 LESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK------ERANN----FE 995
Query: 1041 KQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITI 1090
+IE L+ + NST+ T N D++ + L+ NAKL+ +
Sbjct: 996 HRIEDLTR-QLRNSTLQCET-----INSDNEDLLARIETLQS-NAKLLEV 1038
Score = 68.5 bits (160), Expect = 1e-10
Identities = 151/741 (20%), Positives = 310/741 (41%), Gaps = 63/741 (8%)
Query: 37 IIETQSNPIKLQDSGTIT---ISCKMCQSLKESSNEINLKLEK--LSGELFDIKEQKSAL 91
++E Q N KL ++ + + ++ LKE +E++ E+ + L + E + +
Sbjct: 685 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 744
Query: 92 EGKYQNLILETQTRDL-LMSQIKSLEMENLTKDKEIKNLTDSLKTKS----KKINELQEE 146
+ NL + + L L +IK L+ E++ + +E+K+L + + K++ E+Q E
Sbjct: 745 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 804
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
+ L + ++E ++ E +L E ++Q C E + NE E ++ +
Sbjct: 805 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE-IHNEKEKCFIKEHENLKPL 863
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSI 266
L++ ++ + L K + + S S + + + L+ +++ ++CKE E I
Sbjct: 864 LEQKELRDRRA--ELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI 921
Query: 267 KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID 326
K L + +D K ET+ VK E +L S +QL S +D I
Sbjct: 922 K--LVAVKAKKELDSSRK-------ETQTVK---EELESLRSEKDQL----SASMRDLIQ 965
Query: 327 RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS 386
+ +L+ E + LDV + +N ++ + DL L T +N +L +
Sbjct: 966 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIE-DLTRQLRNSTLQCETINSDNEDLLA 1024
Query: 387 VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSK 446
E L S N++L+E + IL +Q+ + + + + ++KE ++KE T +L +
Sbjct: 1025 RIETLQS-NAKLLEVQ----ILEVQRAKAM-VDKELEAEKLQKEQKIKEHATT-VNELEE 1077
Query: 447 LKIDIPRDLDQ------DLPAHKKI---TILFDALITQYE-----LSR--TDYEIEKEKL 490
L++ + ++ Q +L KK T L + I YE L++ T+ + E L
Sbjct: 1078 LQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDL 1137
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
E K EE + ++K L + K +L L
Sbjct: 1138 EQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ 1197
Query: 551 KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR-EK 609
L E++A + + + ++ ++ + +K+ E + T ++ +L + +T ++
Sbjct: 1198 ASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT--SAEQHQRTLSAYQQRVTALQE 1255
Query: 610 ETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK 669
E +A++ E Q + FE K++ ++ + + LE L
Sbjct: 1256 ECRAAKAE---QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEM---LI 1309
Query: 670 EQCEEKTRDC-SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
+Q + K +D + L+IN+ + + ++ R K +QE E KL + ++
Sbjct: 1310 DQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN 1369
Query: 729 EALKRDYDAAVKDLESSREAV 749
+K ++ V L S E +
Sbjct: 1370 MMMKSEHTQTVSQLTSQNEVL 1390
Score = 53.2 bits (122), Expect = 5e-06
Identities = 102/526 (19%), Positives = 215/526 (40%), Gaps = 32/526 (6%)
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS 586
L +E+ +L V E ++ IK L+E +DAL + A+ E++ LSL +++ K+ E+
Sbjct: 2 LEKEIEELRSKPVTEGTGDI--IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVED 59
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
++ + + + L+ + +E E +EL ++ L K + +
Sbjct: 60 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE 119
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK---TAEIQNRM---I 700
D K L E+ ++ EE+ + +++ T EK ++QN +
Sbjct: 120 QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK-QLDATTDEKKETVTQLQNIIEANS 178
Query: 701 MRLQKQIQ--EDDKLFIE--KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK 756
QK I +++ L ++ + ++ EL + EA ++++A + L +E L Q
Sbjct: 179 QHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKE---NLVKQC 235
Query: 757 DLVEGRI-AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
+ E I + E ++ + AT ++ + L + K
Sbjct: 236 EASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKEL 295
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLK-ERYKELDDECETCAEYLQERDEQ-CA 873
+S S++ D EV+ + L + + +K E + E +D E L ++EQ C
Sbjct: 296 ESQH---SILKD-EVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 351
Query: 874 --RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM-SYD 930
+LK E L +Q EQ + ++ +++ + ++ + M
Sbjct: 352 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 411
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EKYTKKDKEFEA-KRKELEDCKAEL 988
E+ + L + +E + L+ + +Q + E K +EFE+ K+++ D
Sbjct: 412 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 471
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
++L+ + E D ET + E K L + ++ E+ + + N
Sbjct: 472 QKLRTAFTEKDALLETVNRLQGENE---KLLSQQELVPELENTIKN 514
>X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for
embryonic myosin heavy chain. ).
Length = 1940
Score = 89.8 bits (213), Expect = 5e-17
Identities = 205/1097 (18%), Positives = 439/1097 (40%), Gaps = 96/1097 (8%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L ++ ++ K+++++ D +E +
Sbjct: 883 QEKNDLQLQVQAESENLLDAE------ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 936
Query: 91 LEGKYQNLILETQT--RDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
L K + L E +D+ L + +E E + ++KNLT+ L + I +L E
Sbjct: 937 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 996
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L + + + +V+ L K L Q+ DLE + E E K+ + + +
Sbjct: 997 KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-EQEKKL---RVDLE-R 1051
Query: 207 LKENLIQSLHIGYDNTLSKLN-RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
K L L + ++ L N + D + + C LQS++ ED + L F
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV----EDEQTLGLQFQK 1107
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL----------IN 315
L+ +L+E++ K K S+ R L LSE+L I
Sbjct: 1108 KIKELQAR----IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 1163
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSL------DVFEI--LMDNI----------IN 357
K+ + + +D A L E +L V E+ +DN+ +
Sbjct: 1164 LNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1223
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
++++++D++ V +++ ++L+ + E + + + L QK R+
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ ++ + +KE+ + + L++ ++ ++ R L+++ A + + +
Sbjct: 1284 EAGELSRQLEEKESIVSQ-LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342
Query: 478 LSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
L R YE E+E K L+ +KA ++T +A + L E KL
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKA-----NSEVAQWRTKYET--DAIQRTEELEEAQEKL- 1394
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
++ ++ + + ++ K + E ++ E+ N L + K++ N
Sbjct: 1395 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD-----KKQRN 1449
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
K L + T+ +E+QA ELE S + + EL K+K
Sbjct: 1450 FDKVLAEWKTKCEESQA-ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Query: 657 EAKSLLEQ---NLALKEQCEE--KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
E L EQ N + E+ K + + +I + E A +++ L+ Q+ E
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL-ELT 1567
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
++ E + K+ E + E LKR+Y V+ ++S+ +A ++ ++ + + + ++E D+
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA--EVRSRNEAIRLK-KKMEGDLN 1624
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
+ + D L + + + K ++++ + +
Sbjct: 1625 EIE---IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV-ERRAN 1680
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
L+ + + L+ + K + E E +Q Q L K LE + L+
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKK 950
++ R A+ + A D A + + A +E+ K L +T+++L+++
Sbjct: 1741 EVEDASRDARNAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1798
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYL 1009
+ + Q A++ K+ ++ E + +ELE + + E ++ + K L + E
Sbjct: 1799 DEAE------QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELT 1852
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
Q EE K + + ++VDKL + + ++Q E ++ T + + + ++
Sbjct: 1853 YQSEEDRKNVLRLQ---DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEE 1909
Query: 1070 ITDVMKENQKLKKMNAK 1086
D+ + ++ K+ AK
Sbjct: 1910 RADIAE--SQVNKLRAK 1924
Score = 83.4 bits (197), Expect = 4e-15
Identities = 114/533 (21%), Positives = 212/533 (39%), Gaps = 48/533 (9%)
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQ 612
+ EE K +AK+E K L EK LV+ + +E N L+ + E E
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEK------LVTLV----QEKNDLQLQ---VQAESENL 899
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
ER Q+IK F+L+ ++ + L + L+++C
Sbjct: 900 LDAEERCDQLIKAK-FQLEAKIKEV----------TERAEDEEEINAELTAKKRKLEDEC 948
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK 732
E +D LE+ + EK + L +++ D ET + +LT + +AL+
Sbjct: 949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD------ET-IAKLTREKKALQ 1001
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
+ A+ DL++ + VN L K +E ++ +LES + E+ V
Sbjct: 1002 EAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 1061
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYK 852
++ + L E K D + S+V + L Q+++ +L+ R +
Sbjct: 1062 LAQESILDLENDKQQLDERLKKKDFEYCQL----QSKVEDEQTLGLQFQKKIKELQARIE 1117
Query: 853 ELDDECE----TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADV 908
EL++E E T A+ ++R + L++ LE+ QI + +R+A+F +
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK--KREAEFLKL 1175
Query: 909 AVNTDEDWANLHSVVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKA 963
+ +E ++V A+ E+ L + ++L +K + K + + +
Sbjct: 1176 RRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSS 1235
Query: 964 MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAK 1023
ME +K E + LED +E + + E T L+ + R E K
Sbjct: 1236 MESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Query: 1024 IALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
+ IV +LS K A +Q E L + A A+ ++ D+++E
Sbjct: 1296 ES--IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 1346
Score = 75.8 bits (178), Expect = 8e-13
Identities = 185/972 (19%), Positives = 382/972 (39%), Gaps = 90/972 (9%)
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
E E T +E + D L K EL+E+ TL V E ++L +V +N
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTL-------VQEKNDLQLQVQAESENL 899
Query: 176 ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIG---YDNTLSKLNRSISD 232
++C L K + E KI K + + + +E + L ++ S+L + I D
Sbjct: 900 LDAEERCDQLIKAKFQLEAKI--KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE--LHEPNMTMDLDEKLGENNE 290
+ + ++ E A K L E+ + + + E + ++ ++ +
Sbjct: 958 LELT-----LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ 1012
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
E V +++ K L E L ++ ++ K +D ++ D + S+
Sbjct: 1013 AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI----- 1067
Query: 351 LMDNIINKYQIDLDEILEK----YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
+D +K Q LDE L+K Y ++Q + + + +K+ L +++ E E
Sbjct: 1068 -LDLENDKQQ--LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEI--LTKECLKLSKLK----IDIPRDLDQDLP 460
R + + + S ++ + L+E +T ++L+K + + + RDL++
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 461 AHKKITILF-----DALITQYE----LSRTDYEIEKEK--LRLE----TGTAKAVXXXXX 505
H+ + D++ E L R ++EKEK +LE + + ++V
Sbjct: 1185 QHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 506 XXXXXXXXXFDTLEEAHNEVKSLHEELTKL--YKSKVD----ENNANLNLIKILSEEIDA 559
D L EA + + + L++L KS++ E + L + + ++
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 1304
Query: 560 LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERS 619
K A + E++ E++NK ++ + L+ + L + E+E +A EL+R+
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKAKNALA--HALQSSRHDCDLLREQYEEEQEGKA-ELQRA 1361
Query: 620 CQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD 678
+ K + D + +++ +E A+ +C +
Sbjct: 1362 LSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVE---AVNAKCASLEKT 1418
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAA 738
RL+ ++ E N + L K+ + DK+ E +TK E + EA ++ +
Sbjct: 1419 KQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL 1478
Query: 739 VKDLESSREAVNQLTTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXX 796
+L + A + Q + V+ LE +I TEQ A
Sbjct: 1479 STELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
E + + +++ I + S++ ++ +E++ LK Y+ +
Sbjct: 1539 ADIQLALEEAEAA--LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVE 1596
Query: 857 ECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQ----IRTQQPVERQAK---- 904
++ + + RLKK + +E Q+S+ Q ++ + V+ Q K
Sbjct: 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 905 FADVAVNTDEDWANLHSVVVDRMS-YDAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQK 962
D A+ ED ++V R + AEVE+ + ++ E R +Q+L ++ ++Q
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Query: 963 AMEK-----YTKKDKEFEAK--RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
+ +TKK E + + E+ED + +++ K+ + AE LK+ ++
Sbjct: 1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Query: 1016 CKRLKEAKIALE 1027
L+ K LE
Sbjct: 1777 SAHLERMKKNLE 1788
Score = 70.9 bits (166), Expect = 2e-11
Identities = 186/894 (20%), Positives = 350/894 (39%), Gaps = 96/894 (10%)
Query: 245 LQSELDAGRE---DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV--- 298
LQ ++ A E D +E C+ K LE +T +++ N E K K+
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--II 356
SE+K++++ L L E +K H K + L E + ++ + +
Sbjct: 948 CSELKKDIDDLELTLAKVEKEK---HATENK---VKNLTEELSGLDETIAKLTREKKALQ 1001
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+Q LD++ + KV LN+ S+L+ E L S Q EK+ ++ R +++
Sbjct: 1002 EAHQQALDDLQAEEDKVNS-LNKTKSKLEQQVEDLESSLEQ--EKKLRVDLERNKRKLEG 1058
Query: 417 EISSAVT--IDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD---- 470
++ A +D+ + +L E L K+ + +L+ + + L KKI L
Sbjct: 1059 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 471 ---------ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
A + E R+DY E E+L A V F L
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
E HE + + K ++ A L E+ID L+ K E++ SE ++
Sbjct: 1179 LEEATLQHEAMVATLRKKHADSVAELG------EQIDNLQRVKQKLEKEK---SEFKLEI 1229
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
+L S++ + + +L+ I R E Q SE + I+++ EL K+ +
Sbjct: 1230 DDLSSSMESVSKSKANLEK----ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEA 1285
Query: 642 XXXXXXXXXXXXXXDEA----KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ ++ +Q LK Q EE+ + + L +++ ++
Sbjct: 1286 GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ-LTTQK 756
Q+ E + + +++ + KYE D ++LE ++E + Q L +
Sbjct: 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEAQEKLAQRLQDSE 1402
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLD 815
+ VE A+ S +T+Q + ++ L E K +
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+S ++ E S + R LS EL LK Y+E D+ ET +
Sbjct: 1463 ESQ-------AELEASLKESRSLST--ELFKLKNAYEEALDQLET--------------V 1499
Query: 876 KKEKLSLEQQVSNLKEQI----RTQQPVERQAK-----FADVAVNTDEDWANLHSVVVDR 926
K+E +LEQ++++L EQI +T +E+ K AD+ + +E A L
Sbjct: 1500 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 1559
Query: 927 MSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ E+ E ++++ + EE+ K++ + TV MQ A++ + E +K++
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 1619
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALE 1040
E +L E++ + + + ++L+ + Q K + AL + L Q +E
Sbjct: 1620 E---GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676
Query: 1041 KQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
++ L + +T+ + + Q++ D + Q L N LI KK
Sbjct: 1677 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK 1730
Score = 61.3 bits (142), Expect = 2e-08
Identities = 183/925 (19%), Positives = 358/925 (38%), Gaps = 70/925 (7%)
Query: 139 KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVN-ESENKIG 197
K E ++E T+ + E + +L++ L Q+ DL+ V ESEN +
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 198 PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCK 257
+ C Q +K I ++ I+ T+ + L+ E ++D
Sbjct: 902 AEERCDQL-IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK----LEDECSELKKDID 956
Query: 258 ELCEDFTSIKNHLELHEP-NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+L + T K E H N +L E+L +E K + ++ + L
Sbjct: 957 DL--ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 317 ESKKSKDHIDRYKDSL-LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQG 375
E K + +++ K L V D E + ++ K + DL E ++
Sbjct: 1015 EDKVNS--LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN 1072
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE 435
D + LK + + L S+ +E E L+ QK +I E+ + I+ +++E E E
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSK-VEDEQTLG-LQFQK-KIKELQAR--IEELEEEIEA-E 1126
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG 495
T+ K K + D R+L++ +++ TQ EL++ + E E L+L
Sbjct: 1127 RATRA--KTEKQRSDYARELEE---LSERLEEAGGVTSTQIELNK---KREAEFLKLRRD 1178
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK------VDENNANL-- 547
+A D++ E ++ +L KL K K +D+ ++++
Sbjct: 1179 LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Query: 548 ------NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL 601
NL KI D L A KNEE SLSE + + L + L + +S+
Sbjct: 1239 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
++R K+ + E + +++ + + A L E K+
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNAL-AHALQSSRHDCDLLREQYEEEQEGKAE 1357
Query: 662 LEQNLALKEQCEEKTRDCSRLEIN-IKTHEKTAEIQNRMIMRLQ---KQIQEDDKLFIEK 717
L++ AL + E + ++ E + I+ E+ E Q ++ RLQ +Q++ +
Sbjct: 1358 LQR--ALSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 718 ETKLNELTNKYEALKRDYDAA---VKDLESSREAVNQLTTQ-KDLVEGRIAELESDIRTE 773
E L + E L D + A L+ + +++ + K E AELE+ ++
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN-PKLDDSPKRSISVISDSEVSQ 832
++ + T EN++L + L + + I + E S+
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLE----TVKRENKNLEQEIADLTEQIAENGKTIHELEKSR 1531
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
+ L +L L+E L+ E E + + + ++ ++++ LK
Sbjct: 1532 KQIELEKADIQLA-LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRN 1590
Query: 893 IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLMKTIEELRYK 949
Q+ VE D V + + L + ++ + E++ N++ +T++ LR
Sbjct: 1591 Y--QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN-EIEIQLSHANRQAAETLKHLRSV 1647
Query: 950 KQDLKNTVTKMQKAM-------EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEEC 1002
+ LK+T + A+ E+ ++ + E+E+ +A LE+ ++ K ++E
Sbjct: 1648 QGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQEL 1707
Query: 1003 ETCAEYLKQREEQCKRLKEAKIALE 1027
E ++ Q L K LE
Sbjct: 1708 LDSNERVQLLHTQNTSLIHTKKKLE 1732
Score = 52.4 bits (120), Expect = 9e-06
Identities = 61/284 (21%), Positives = 126/284 (44%), Gaps = 29/284 (10%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC--------------AEYLQER 868
S ++ E++ +KE + EL + + KEL+++ T +E L +
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
+E+C +L K K LE ++ + E R + E A+ +++ + L + D
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAE 987
A+VEK K + K ++L ++ + + + K T++ K EA ++ L+D +AE
Sbjct: 961 TLAKVEKEKHATEN------KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 988 ---LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA-LEKQI 1043
+ L + +L+++ E L+Q ++ L+ K LE KL+ + + LE
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ L Y S + Q + ++ +K+K++ A++
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLG--LQFQKKIKELQARI 1116
Score = 50.0 bits (114), Expect = 5e-05
Identities = 56/259 (21%), Positives = 107/259 (41%), Gaps = 14/259 (5%)
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
++E+ +KE +++ DE +E +E+ L +EK L+ QV E + + E
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE--E 904
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + + D +AE+ K ++L EL+ DL+ T+ K
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++K EK+ ++K + +EL + +L + K L E + + L+ E++ L
Sbjct: 965 VEK--EKHATENK-VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSL 1021
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQ 1078
+ K KL Q LE +E V G + + I D+ + Q
Sbjct: 1022 NKTK------SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
Query: 1079 KL-KKMNAKLITICKKRGK 1096
+L +++ K C+ + K
Sbjct: 1076 QLDERLKKKDFEYCQLQSK 1094
Score = 41.5 bits (93), Expect = 0.016
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 3/97 (3%)
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
K + + + M++ +K + + EAKRKELE+ +L L Q +L + + +E
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEE---KLVTLVQEKNDLQLQVQAESEN 898
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L EE+C +L +AK LE K ++ E++I +
Sbjct: 899 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINA 935
Score = 33.9 bits (74), Expect = 3.2
Identities = 23/87 (26%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + K + +KE ++E + K EL + + + KEL+E+ T + + Q + E
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESE 897
Query: 1022 AKI-ALEIVDKLSNQKVALEKQIESLS 1047
+ A E D+L K LE +I+ ++
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAKIKEVT 924
>AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 89.0 bits (211), Expect = 8e-17
Identities = 189/968 (19%), Positives = 385/968 (39%), Gaps = 78/968 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ SL+ + +K +K T S + + + E ++ + L N E+ L++++D
Sbjct: 499 SQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD 558
Query: 170 DLKKNNECLT-----QKCIDL-----EKLVNESENKIGPKNICAQCKLKENLIQSL---- 215
+ N+ +K +DL +KL+NE + K+ + K++E + Q
Sbjct: 559 KTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL-----TLEFKIREEVTQEFTQYW 613
Query: 216 ---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL 272
+ TL + R I + N R L + D E K++C T ++ E
Sbjct: 614 AQREADFKETLLQ-EREILEENAERRLAIFKDLVGKCDTREEAAKDICA--TKVETE-ET 669
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK--KSKDHIDRYKD 330
H D+ + L +N K ++ +L E E K + K + + K
Sbjct: 670 HNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKG 729
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L+ + L E D++I + + +I+ + +++ +N + ++NE
Sbjct: 730 ELIKTKE------ELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINE- 782
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-EL-KEILTKECLKLSKLK 448
+L S + E CN ++ S + ++ E E+ K+ +K C + ++
Sbjct: 783 FQNLKSHM-ENTFKCN------DKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVN 835
Query: 449 IDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE---IEKEKLRLETGTAKAVXXXXX 505
+L QD P KK +I + IT+ + + E E +R+ + +
Sbjct: 836 ---ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 892
Query: 506 XXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIA 565
+ E + ++ +EL+ K + + + I L + +
Sbjct: 893 TIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKS 952
Query: 566 KNEEKMLSLSEKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
KN+E+ + + N++ T S N + + ++++ T + +Q S ++
Sbjct: 953 KNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDL 1012
Query: 625 QNGFELDKM---KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCS 680
NG E D + + D+L ++ ++ A+ E+C+E + S
Sbjct: 1013 SNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASS 1072
Query: 681 RLEINIKTHEKTAEIQNRMIM-------RL-QKQIQEDDKLFIEKETKLNELTNKYEALK 732
+ I+ E+ E + RL +K+ + D L EKET + +L + +
Sbjct: 1073 KKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKN 1132
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
D ++ + + A+++LT + +I ELE+ + T++
Sbjct: 1133 VTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKES 1192
Query: 793 XXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
+ L ++ K D + + + E++QL L + L LKE
Sbjct: 1193 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKEEE 1249
Query: 852 KELD-DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
+E + E E E L + LK + E+ ++LKE++ + +Q + +V+V
Sbjct: 1250 EETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEVSV 1308
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYT 968
DED L + ++ + + MK TI++L K+ L N K+++A+++Y
Sbjct: 1309 MRDED--KLLRIKINELEKKKNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQYE 1361
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ K+ K K +ED + LEE +Q E D+ E E +++ + ++ KE LE
Sbjct: 1362 RACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLET 1421
Query: 1029 VDKLSNQK 1036
+ + K
Sbjct: 1422 KNNQRSNK 1429
Score = 71.7 bits (168), Expect = 1e-11
Identities = 180/947 (19%), Positives = 379/947 (40%), Gaps = 71/947 (7%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEM 117
C LK N+I +L K GEL KE+ E + +LI LET + ++ + E+
Sbjct: 712 CLELK--FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL 769
Query: 118 ENLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
N+ KE N +LK+ + + ++ DT S+LI+ N N EV K+
Sbjct: 770 INIIDQKEDTINEFQNLKSHMENTFKCNDKADT-SSLIINNKLIC-NETVEVPKDSKSKI 827
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
C +K ++ E + + E +I + E+ +S + + + R + ++N
Sbjct: 828 CSERKRVN-ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 886
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE-PNMTMDLDEKLGENNEFETKA 295
R + T+++EL +E+ EL + + L L E N+T+ + + ++N ++
Sbjct: 887 LR-AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN-YDIAI 944
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDN 354
++ ++++ N E+ I K + I+ S+ V + T +D L D+
Sbjct: 945 AEL--HVQKSKNQEQEEKI----MKLSNEIETATRSITNNVSQIKLMHTKIDELRTL-DS 997
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSV-NEKLAS--LNSQLIEKENACNILRIQ 411
+ IDL + + + D N ++L + N+ L S + I++ N N
Sbjct: 998 VSQISNIDLLNLRDLSNGSEED-NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1056
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
E I E + KK ++++E+ ++ KL+ ++ D++ +K D
Sbjct: 1057 IEAIWEECKEIVKASSKKSHQIEELEQ----QIEKLQAEVKGYKDENNRLKEKEHKNQDD 1112
Query: 472 LITQYE--LSRTDYEIEKEKLRLETG-----TAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
L+ + E + + E++++ + L+ K LE
Sbjct: 1113 LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 1172
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
K KL + +++ + L L + L E + L+ ++ KN + L+ K+ KL E
Sbjct: 1173 QKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV-KNTK---DLNVKELKLKEE 1228
Query: 585 VSTI-NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
++ + N L++ +K L + E+ET E E+ + + + +KAD+
Sbjct: 1229 ITQLTNNLQD----MKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1284
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
+ K + ++ ++++ + + LE + +++ R I +L
Sbjct: 1285 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1344
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
++Q+ K+ E +YE +D + K +E R + + Q + + ++
Sbjct: 1345 KEQLNNQ---------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQV 1394
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E + + E+ AT + LG+ L D + S
Sbjct: 1395 LEAKLE-EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQ 1453
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
+ L+E+++ Q + R KE+ +Y ++R+ R K++ +E
Sbjct: 1454 KYNADRKKWLEEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEME 1502
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ L E+ +++ + D V E L +++ + D E+E+ KR++
Sbjct: 1503 ILTAQLTEK---DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISET 1557
Query: 944 EELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ + D+K ++ + FE R ++ED L+
Sbjct: 1558 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 1604
Score = 62.9 bits (146), Expect = 6e-09
Identities = 216/1091 (19%), Positives = 442/1091 (40%), Gaps = 116/1091 (10%)
Query: 62 SLKESSNE--INLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQTRD--LLMSQIKSL 115
SL +SN +N+K +S E L D+ E + +E + +N ETQ + LL +
Sbjct: 503 SLDSNSNSKILNVKRATISWENSLEDLMEDEDLVE-ELENAE-ETQNVETKLLDEDLDKT 560
Query: 116 EMEN--LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDN---LNKEVD- 169
EN +E + L D ++ KK+ ++E TL I E VT+ +E D
Sbjct: 561 LEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADF 620
Query: 170 --DLKKNNECLTQ----KCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIGYDNT 222
L + E L + + + LV + + + K+ICA K++ + ++G+++
Sbjct: 621 KETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICAT-KVETEETHN-YVGFEDI 678
Query: 223 LSKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD 280
+ L +++D + I +L +A C EL F IK L + +
Sbjct: 679 IDSLQDNVADIKKQAEIAHLYIASLPDPQEATA--CLEL--KFNQIKAELAKTKGELIKT 734
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNL--NSLSEQLINNESKKSKDHIDRYKDSLLAVLDA 338
+E NE ++ ++ + K+ + N ++LIN +K +D I+ +++ L + ++
Sbjct: 735 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQN-LKSHMEN 792
Query: 339 EFGTTS-LDVFEILMDN--IINK-YQIDLD---EILEKYTKV-QGDLNECTSELK--SVN 388
F D ++++N I N+ ++ D +I + +V + +L + K S++
Sbjct: 793 TFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIH 852
Query: 389 EKLASLNSQLIEKENACNILRIQKERI-HEISSAVTIDIVKKENELKEILTKECLKLSKL 447
A Q +E NI I+ R+ E + + ++ ENELK +E +L+K
Sbjct: 853 VSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNE-KEEKAELNKQ 911
Query: 448 KIDIPRDLD----QDLPAHKKITIL---FDALITQYELSRTDYEIEKEK---LRLETGTA 497
+ ++L ++L K++ + +D I + + ++ + ++EK L E TA
Sbjct: 912 IVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETA 971
Query: 498 KAVXXXXXXXXXXXXXXFDTLE--EAHNEVKSLHE-ELTKLYKSKVDEN--NANLNLIK- 551
D L ++ +++ ++ L L ++N N L+L+
Sbjct: 972 TRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGN 1031
Query: 552 --ILSEEIDALKIAIAKNEEKMLSLSEKD-NKLTELVSTINGLKEENNSLKSLNDVITRE 608
++S+++ +I E S E + E+V + + L+ + + E
Sbjct: 1032 DYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAE 1091
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
+ E R + +N +L K K ++ + + ++E AL
Sbjct: 1092 VKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV--QIQHVVEGKRAL 1149
Query: 669 KEQCEEKTRDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
E + T C + +I ++T +T +++ +L++ I E + + ++ E L E
Sbjct: 1150 SELTQGVT--CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEH 1207
Query: 728 YE-ALKRDYDAAVKDLESSREAV---NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXX 783
+ ++K D VK+L+ E N L K L++ + E E++ + +
Sbjct: 1208 LQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS 1267
Query: 784 XXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE------VSQLKERL 837
+ D L + K ++ +SV+ D + +++L+++
Sbjct: 1268 SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKK 1327
Query: 838 LSCQQELDDLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
C QELD + ++L ++ + E +Q+ + C L ++ +E L+EQ +T
Sbjct: 1328 NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1387
Query: 896 Q-----------QPVERQA--------KFADVAVNTDEDWANLHSVVVDRMS-------- 928
Q + VER A K D+ ++ H D +
Sbjct: 1388 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1447
Query: 929 -YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
++E + N K +EE K K M+KY + + F ++ E+E A+
Sbjct: 1448 LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQ 1507
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQI 1043
L E ++ EE + L E Q K L + + +E + ++ ++ +E QI
Sbjct: 1508 LTEKDSDLQKWREERDQLVAAL---EIQLKALISSNVQKDNEIEQLKRIISETSKIETQI 1564
Query: 1044 ESLSNTPVSNS 1054
+ +S++
Sbjct: 1565 MDIKPKRISSA 1575
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 1401 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 1458
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 1459 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1518
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 1519 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1572
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 1573 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 1626
>AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 89.0 bits (211), Expect = 8e-17
Identities = 189/968 (19%), Positives = 385/968 (39%), Gaps = 78/968 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ SL+ + +K +K T S + + + E ++ + L N E+ L++++D
Sbjct: 499 SQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD 558
Query: 170 DLKKNNECLT-----QKCIDL-----EKLVNESENKIGPKNICAQCKLKENLIQSL---- 215
+ N+ +K +DL +KL+NE + K+ + K++E + Q
Sbjct: 559 KTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL-----TLEFKIREEVTQEFTQYW 613
Query: 216 ---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL 272
+ TL + R I + N R L + D E K++C T ++ E
Sbjct: 614 AQREADFKETLLQ-EREILEENAERRLAIFKDLVGKCDTREEAAKDICA--TKVETE-ET 669
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK--KSKDHIDRYKD 330
H D+ + L +N K ++ +L E E K + K + + K
Sbjct: 670 HNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKG 729
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L+ + L E D++I + + +I+ + +++ +N + ++NE
Sbjct: 730 ELIKTKE------ELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINE- 782
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-EL-KEILTKECLKLSKLK 448
+L S + E CN ++ S + ++ E E+ K+ +K C + ++
Sbjct: 783 FQNLKSHM-ENTFKCN------DKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVN 835
Query: 449 IDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE---IEKEKLRLETGTAKAVXXXXX 505
+L QD P KK +I + IT+ + + E E +R+ + +
Sbjct: 836 ---ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLL 892
Query: 506 XXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIA 565
+ E + ++ +EL+ K + + + I L + +
Sbjct: 893 TIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKS 952
Query: 566 KNEEKMLSLSEKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
KN+E+ + + N++ T S N + + ++++ T + +Q S ++
Sbjct: 953 KNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDL 1012
Query: 625 QNGFELDKM---KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCS 680
NG E D + + D+L ++ ++ A+ E+C+E + S
Sbjct: 1013 SNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASS 1072
Query: 681 RLEINIKTHEKTAEIQNRMIM-------RL-QKQIQEDDKLFIEKETKLNELTNKYEALK 732
+ I+ E+ E + RL +K+ + D L EKET + +L + +
Sbjct: 1073 KKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKN 1132
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
D ++ + + A+++LT + +I ELE+ + T++
Sbjct: 1133 VTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKES 1192
Query: 793 XXXXXXXTFGDENRDLGENPK-LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
+ L ++ K D + + + E++QL L + L LKE
Sbjct: 1193 IILKLERNLKEFQEHLQDSVKNTKDLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKEEE 1249
Query: 852 KELD-DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
+E + E E E L + LK + E+ ++LKE++ + +Q + +V+V
Sbjct: 1250 EETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEVSV 1308
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYT 968
DED L + ++ + + MK TI++L K+ L N K+++A+++Y
Sbjct: 1309 MRDED--KLLRIKINELEKKKNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQYE 1361
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ K+ K K +ED + LEE +Q E D+ E E +++ + ++ KE LE
Sbjct: 1362 RACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLET 1421
Query: 1029 VDKLSNQK 1036
+ + K
Sbjct: 1422 KNNQRSNK 1429
Score = 71.7 bits (168), Expect = 1e-11
Identities = 180/947 (19%), Positives = 379/947 (40%), Gaps = 71/947 (7%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEM 117
C LK N+I +L K GEL KE+ E + +LI LET + ++ + E+
Sbjct: 712 CLELK--FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL 769
Query: 118 ENLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
N+ KE N +LK+ + + ++ DT S+LI+ N N EV K+
Sbjct: 770 INIIDQKEDTINEFQNLKSHMENTFKCNDKADT-SSLIINNKLIC-NETVEVPKDSKSKI 827
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
C +K ++ E + + E +I + E+ +S + + + R + ++N
Sbjct: 828 CSERKRVN-ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 886
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE-PNMTMDLDEKLGENNEFETKA 295
R + T+++EL +E+ EL + + L L E N+T+ + + ++N ++
Sbjct: 887 LR-AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN-YDIAI 944
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDN 354
++ ++++ N E+ I K + I+ S+ V + T +D L D+
Sbjct: 945 AEL--HVQKSKNQEQEEKI----MKLSNEIETATRSITNNVSQIKLMHTKIDELRTL-DS 997
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSV-NEKLAS--LNSQLIEKENACNILRIQ 411
+ IDL + + + D N ++L + N+ L S + I++ N N
Sbjct: 998 VSQISNIDLLNLRDLSNGSEED-NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1056
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
E I E + KK ++++E+ ++ KL+ ++ D++ +K D
Sbjct: 1057 IEAIWEECKEIVKASSKKSHQIEELEQ----QIEKLQAEVKGYKDENNRLKEKEHKNQDD 1112
Query: 472 LITQYE--LSRTDYEIEKEKLRLETG-----TAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
L+ + E + + E++++ + L+ K LE
Sbjct: 1113 LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 1172
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
K KL + +++ + L L + L E + L+ ++ KN + L+ K+ KL E
Sbjct: 1173 QKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV-KNTK---DLNVKELKLKEE 1228
Query: 585 VSTI-NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
++ + N L++ +K L + E+ET E E+ + + + +KAD+
Sbjct: 1229 ITQLTNNLQD----MKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1284
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
+ K + ++ ++++ + + LE + +++ R I +L
Sbjct: 1285 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1344
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
++Q+ K+ E +YE +D + K +E R + + Q + + ++
Sbjct: 1345 KEQLNNQ---------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQV 1394
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E + + E+ AT + LG+ L D + S
Sbjct: 1395 LEAKLE-EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQ 1453
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
+ L+E+++ Q + R KE+ +Y ++R+ R K++ +E
Sbjct: 1454 KYNADRKKWLEEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEME 1502
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ L E+ +++ + D V E L +++ + D E+E+ KR++
Sbjct: 1503 ILTAQLTEK---DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISET 1557
Query: 944 EELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ + D+K ++ + FE R ++ED L+
Sbjct: 1558 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 1604
Score = 62.9 bits (146), Expect = 6e-09
Identities = 216/1091 (19%), Positives = 442/1091 (40%), Gaps = 116/1091 (10%)
Query: 62 SLKESSNE--INLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQTRD--LLMSQIKSL 115
SL +SN +N+K +S E L D+ E + +E + +N ETQ + LL +
Sbjct: 503 SLDSNSNSKILNVKRATISWENSLEDLMEDEDLVE-ELENAE-ETQNVETKLLDEDLDKT 560
Query: 116 EMEN--LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDN---LNKEVD- 169
EN +E + L D ++ KK+ ++E TL I E VT+ +E D
Sbjct: 561 LEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADF 620
Query: 170 --DLKKNNECLTQ----KCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIGYDNT 222
L + E L + + + LV + + + K+ICA K++ + ++G+++
Sbjct: 621 KETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICAT-KVETEETHN-YVGFEDI 678
Query: 223 LSKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD 280
+ L +++D + I +L +A C EL F IK L + +
Sbjct: 679 IDSLQDNVADIKKQAEIAHLYIASLPDPQEATA--CLEL--KFNQIKAELAKTKGELIKT 734
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNL--NSLSEQLINNESKKSKDHIDRYKDSLLAVLDA 338
+E NE ++ ++ + K+ + N ++LIN +K +D I+ +++ L + ++
Sbjct: 735 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQN-LKSHMEN 792
Query: 339 EFGTTS-LDVFEILMDN--IINK-YQIDLD---EILEKYTKV-QGDLNECTSELK--SVN 388
F D ++++N I N+ ++ D +I + +V + +L + K S++
Sbjct: 793 TFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIH 852
Query: 389 EKLASLNSQLIEKENACNILRIQKERI-HEISSAVTIDIVKKENELKEILTKECLKLSKL 447
A Q +E NI I+ R+ E + + ++ ENELK +E +L+K
Sbjct: 853 VSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNE-KEEKAELNKQ 911
Query: 448 KIDIPRDLD----QDLPAHKKITIL---FDALITQYELSRTDYEIEKEK---LRLETGTA 497
+ ++L ++L K++ + +D I + + ++ + ++EK L E TA
Sbjct: 912 IVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETA 971
Query: 498 KAVXXXXXXXXXXXXXXFDTLE--EAHNEVKSLHE-ELTKLYKSKVDEN--NANLNLIK- 551
D L ++ +++ ++ L L ++N N L+L+
Sbjct: 972 TRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGN 1031
Query: 552 --ILSEEIDALKIAIAKNEEKMLSLSEKD-NKLTELVSTINGLKEENNSLKSLNDVITRE 608
++S+++ +I E S E + E+V + + L+ + + E
Sbjct: 1032 DYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAE 1091
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
+ E R + +N +L K K ++ + + ++E AL
Sbjct: 1092 VKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV--QIQHVVEGKRAL 1149
Query: 669 KEQCEEKTRDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
E + T C + +I ++T +T +++ +L++ I E + + ++ E L E
Sbjct: 1150 SELTQGVT--CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEH 1207
Query: 728 YE-ALKRDYDAAVKDLESSREAV---NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXX 783
+ ++K D VK+L+ E N L K L++ + E E++ + +
Sbjct: 1208 LQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSAS 1267
Query: 784 XXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE------VSQLKERL 837
+ D L + K ++ +SV+ D + +++L+++
Sbjct: 1268 SARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKK 1327
Query: 838 LSCQQELDDLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
C QELD + ++L ++ + E +Q+ + C L ++ +E L+EQ +T
Sbjct: 1328 NQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1387
Query: 896 Q-----------QPVERQA--------KFADVAVNTDEDWANLHSVVVDRMS-------- 928
Q + VER A K D+ ++ H D +
Sbjct: 1388 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1447
Query: 929 -YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
++E + N K +EE K K M+KY + + F ++ E+E A+
Sbjct: 1448 LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQ 1507
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQI 1043
L E ++ EE + L E Q K L + + +E + ++ ++ +E QI
Sbjct: 1508 LTEKDSDLQKWREERDQLVAAL---EIQLKALISSNVQKDNEIEQLKRIISETSKIETQI 1564
Query: 1044 ESLSNTPVSNS 1054
+ +S++
Sbjct: 1565 MDIKPKRISSA 1575
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 1401 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 1458
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 1459 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1518
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 1519 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1572
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 1573 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 1626
>AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome associated
protein protein.
Length = 2442
Score = 89.0 bits (211), Expect = 8e-17
Identities = 184/1002 (18%), Positives = 417/1002 (41%), Gaps = 68/1002 (6%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIK----SLEM 117
SL + ++ ++E L +L + + +E + Q + ETQ + + +++ SL +
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
+ K++ + L ++ + ++++ L+++ E + + L +EV + K +
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADF 1117
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L Q+ LE+L + I + + A +E LH+ +T S+L ++
Sbjct: 1118 LAQEAQLLEEL---EASHITEQQLRASLWAQEAKAAQLHLRLRSTESQLEALAAEQQPGN 1174
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
+ L S A ++ +CE + + ++ D+ G + F+ +
Sbjct: 1175 QAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN-GARSLFKRGPLL 1233
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+ ++L + ++ + K++ D +D + L+ T + ++ + +
Sbjct: 1234 TALSAEAVASALLK--LHQDLWKTQQTRDVLRDQVQK-LEERLTDTEAEKSQVHTE--LQ 1288
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
Q L + E+ +K +G N SEL ++E +ASL S+L E + R++ + E
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----LQRMEAQGERE 1344
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ A ++ + L+ + + + S I L++DL + L + + E
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGI-----LEEDLRTARSALKLKNE---EVE 1396
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYK 537
R + +E+ L+ KA+ + +E +++ L E+ ++ K
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQEL-EKQREMQK 1455
Query: 538 SKVDENNANLNL----IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+ ++ + +L + + E+I L+ + E +++ E++ KLT I +E
Sbjct: 1456 AALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI---RE 1512
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
++ +V+ E Q ELE+ Q+I+ ++ +K ++
Sbjct: 1513 PEKDRETQRNVL----EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
+ K + E L+ Q E + + L ++++ + + Q+ I L+ +
Sbjct: 1569 MECQQKLIKE----LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE 1624
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E++ ++ + E L+R + +DLE + +L QK+ RI LE D RT
Sbjct: 1625 LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ---ELMLQKE----RIQVLE-DQRTR 1676
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXT-FGDENRDLGENPKLDDSPKRSISVISDSEVSQ 832
QT + E + G+ P S + S+ + +
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP----SKAQRGSLEHMKLILR 1732
Query: 833 LKERLLSCQQE-LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
KE+ + CQQE + +L+E +L+ + + + E ++ ++E + L+QQ+ +E
Sbjct: 1733 DKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEARE 1792
Query: 892 QIRT-QQPVERQAKFADVAV-NTDEDWANLHSVVVDRMSYDAEV-EKNKRLMKTIEE--- 945
Q +Q ++ Q A A+ D++ L + V EK L +E+
Sbjct: 1793 QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHM 1852
Query: 946 -LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
L+ + +L++ + ++ E+ + + +A + L D +AE E ++ L ++
Sbjct: 1853 TLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQ--- 1909
Query: 1005 CAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV-ALEKQIES 1045
CAE ++ E + + L+++ + + V K +Q++ AL + +S
Sbjct: 1910 CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Score = 74.9 bits (176), Expect = 1e-12
Identities = 197/1041 (18%), Positives = 418/1041 (40%), Gaps = 75/1041 (7%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIK----EQKSALEGKYQNLILETQT-RDLLMSQI 112
K +SL+ E+ ++L++ E+ I+ E+++ E + LET+ R L+ +
Sbjct: 875 KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL 934
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTE-SDNLNKEVDDL 171
+ E ++++ L +K + K+ E QE L + E E + + DDL
Sbjct: 935 LQTQKELADASQQLERLRQDMKVQ--KLKE-QETTGILQTQLQEAQRELKEAARQHRDDL 991
Query: 172 ---KKNNECLTQKCIDLEKLVNESENKIGPKNICAQC---KLKENLIQSLHIGYDNTLSK 225
++ + L Q +DL+K V + ++++ ++ + +++E L ++ Y+ +
Sbjct: 992 AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE--YNRIQKE 1049
Query: 226 LNRSISDSNTST--RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE 283
L R + S + ++ LQ +++ L +D + + M + E
Sbjct: 1050 LEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
Query: 284 KLGENNEFETKAVKVMSEIKRNL---NSLSEQLINNESKKSKDHID-RYKDSLLAVLDAE 339
+ +F + +++ E++ + L L E+K ++ H+ R +S L L AE
Sbjct: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLHLRLRSTESQLEALAAE 1169
Query: 340 FGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTS------ELKSVNE--KL 391
+ + + ++ + Q L + E ++ G + S + K
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
Query: 392 ASLNSQLIEKENACNILRIQKE--RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI 449
L + L + A +L++ ++ + + + + K E L + ++ ++L+
Sbjct: 1230 GPLLTALSAEAVASALLKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQ- 1288
Query: 450 DIPRDLDQDLPAHKKITILFDALITQY-ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
D+ R L Q+ K ++L ++ EL T ++ R E +A
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQA 1348
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI-AIAKN 567
+E V + + + D A + +K+ +EE+++ + A A
Sbjct: 1349 AKENLTAQ-VEHLQAAVVEARAQASAAGILEEDLRTAR-SALKLKNEEVESERERAQALQ 1406
Query: 568 EEKMLSLSEK---DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
E+ L +++ L L T+ +EE +L+ + +++E Q + LE +K
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ E+D + I + + L Q ++E EK R+ R
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREP--EKDRETQR--- 1521
Query: 685 NIKTHEKTA-EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
N+ H+ E +++MI + Q+Q+ K + E EL + ++ +K+LE
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ-QKLIKELE 1580
Query: 744 SSREAVNQLTTQKDL-VEGRIAELE---SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
RE T L +E R EL+ S I ++ +
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 800 TFGDENRDLGENPKLDDSP----KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD 855
+ L ++ + D K I V+ D Q K +++L+ +K +E
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK----ILEEDLEQIKLSLRERG 1696
Query: 856 DECETCAEYLQERDEQC-ARLKKEKLSLEQQVSNLKE---QIRTQQPVERQAKFADVAVN 911
E T + +QER E+ K ++ SLE L++ ++ QQ E + ++
Sbjct: 1697 RELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ--EHIHELQELKDQ 1754
Query: 912 TDEDWANLHSVVVDRMSYDAEVEKN-----KRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
++ LH V + ++ E+ ++L + E+ K+Q L++ + + Q+A+
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL-- 1812
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL 1026
++D+E EA ++E + + + E +K++ L E LK+R + + KE L
Sbjct: 1813 -AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL 1871
Query: 1027 EIVDKLSNQKV-ALEKQIESL 1046
E + ++V ALE+ + L
Sbjct: 1872 EEELAVEGRRVQALEEVLGDL 1892
Score = 61.3 bits (142), Expect = 2e-08
Identities = 184/980 (18%), Positives = 388/980 (39%), Gaps = 73/980 (7%)
Query: 68 NEINLKLEKLSGELFDIKEQKSALEGKYQNLILET----QTRDLLMSQIKSLEMENLTKD 123
++++ +L+ L +L +E+KS EGK +L E +T L S+++ E++ +
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
Query: 124 KEIKNLTDSLKTKSKKINELQEE-NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
E + L + + + ++ LQ + + + E D L LK NE + +
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED-LRTARSALKLKNEEVESER 1399
Query: 183 IDLEKLVNESENKIG-----PKNICAQCKL---KENLIQSLHIGYDNTLSKLNRSISDSN 234
+ L + E K+ +N+ + +E +++L G L K R + +
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR-GQIQELEK-QREMQKAA 1457
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETK 294
+ E+D +E +EL E S+ HL P + ++KL E + +
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQIQEL-EKCRSVLEHL----PMAVQEREQKLTVQRE-QIR 1511
Query: 295 AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+ E +RN+ L QL+ E KD + + + L + T E+ ++
Sbjct: 1512 EPEKDRETQRNV--LEHQLLELE---KKDQMIESQRGQVQDLKKQLVTLECLALELEENH 1566
Query: 355 IINKYQIDLDEILEKYTKVQG-DLNECTSELKSVNEKLASLNSQLIEKENACNIL-RIQK 412
+ Q L + LE + Q L T +L+ +++L + +SQ+ + E+ +L R +
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-KITILFDA 471
ER E+ S + +++ KE LT+ D+ R DQ+L K +I +L D
Sbjct: 1627 ERDQEVKS--QREQIEELQRQKEHLTQ----------DLER-RDQELMLQKERIQVLEDQ 1673
Query: 472 LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
Q ++ D E K LR E G + E H +
Sbjct: 1674 RTRQTKILEEDLEQIKLSLR-ERGRELTTQRQLMQERAEEGKGPSKAQRGSLE----HMK 1728
Query: 532 LTKLYKSK-VDENNANLNLIKILSEEID-ALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
L K K V+ +++ ++ L ++++ L+ K E L LS+++ ++ L +
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
Query: 590 GLKEE----NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+E+ SL+S D R + ELE Q +Q + +++K
Sbjct: 1789 EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
E + EQ L+E+ + R LE + + Q + ++ LQ+
Sbjct: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL----ESSREAVNQLTTQKDLVEG 761
Q E + + L + + +A+ ++ D ++ L +SSR + + ++
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQE 1968
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
+ + + ++ ++ + +R L E ++ + +
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD 2028
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ +V QL++ L +EL +ER + L+ + +++Q L++E
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGLERE--- 2085
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK 941
E+++ L + +R Q Q + + + + NL ++ + E + K
Sbjct: 2086 -EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK---- 2140
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
++ L + L+ + ++Q A+ + ++ E+ R++ +D L + K L E
Sbjct: 2141 -LDSLEPR---LQRELERLQAALRQTEAREIEW---REKAQDLALSLAQTKASVSSLQEV 2193
Query: 1002 CETCAEYLKQREEQCKRLKE 1021
+ +R+ + +RL++
Sbjct: 2194 AMFLQASVLERDSEQQRLQD 2213
Score = 60.1 bits (139), Expect = 4e-08
Identities = 137/723 (18%), Positives = 283/723 (39%), Gaps = 48/723 (6%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNILRIQKER 414
+ K + D + + +QG+++ + E + + + L QL + ++ A + R+ E
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
+ SA +++ E + +E +L ++ + + + L + +++
Sbjct: 497 QLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESIHL 554
Query: 475 QYELSRTDY-EIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE-EAHNEVKSLHEE- 531
+ EL R + E+ R E A+ ++ A NE +L +
Sbjct: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + +EN + + ++ + +AL++ +A+ E++ +L EK+ T L + +
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN---THLEAQLQKA 671
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+E L++ I EKE +L S + +L+++ +
Sbjct: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQE-------AKRQEEVL 724
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
E ++L+ + AL+ + + RD L ++ E+ + Q+Q D
Sbjct: 725 ARAVQEKEALVREKAALEVRLQAVERDRQDLAAQLQGLSSAKELLESSLFEAQQQNSVID 784
Query: 712 KLFIEKETKLNELTNKYE-------ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIA 764
+ + E ++ +T E LK + D E R+A + Q + EG+ A
Sbjct: 785 EPQGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE-QEGKTA 843
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV 824
+ E+ + E +L K + +I
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQ 884
+ E +Q + L CQ +L+ KER L+ +T E L + +Q RL++ +
Sbjct: 904 QREEERTQAESAL--CQMQLETEKERVSLLETLLQTQKE-LADASQQLERLRQ-----DM 955
Query: 885 QVSNLKEQ----IRTQQPVERQAKFADVAVNTDEDWANLH----SVVVDRMSYDAEVEKN 936
+V LKEQ I Q E Q + + A +D A L S++ D+M +VE
Sbjct: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015
Query: 937 K-RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
K +L+ + R +Q+++ + + Q +Y + KE E ++ L E E+
Sbjct: 1016 KSQLVAQDDSQRLVEQEVQEKLRETQ----EYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 996 KELDEECETCAEYLKQREEQCK-RLKEAKIALEIVDKLSNQKVA--LEKQIESLSNTPVS 1052
+E D + L+Q ++ + KE +E++ + +K A L ++ + L S
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
Query: 1053 NST 1055
+ T
Sbjct: 1132 HIT 1134
Score = 52.8 bits (121), Expect = 7e-06
Identities = 55/267 (20%), Positives = 124/267 (46%), Gaps = 8/267 (2%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
RS + + EV +ER + Q++ + + K L + + L ER+E+ L+ +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 880 LSLEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
LE+Q K + ++++ + D+ ++ SV+ + + + E+ ++
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL-EHLPMAVQ-EREQK 1502
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L E++R ++D + ++ + + KKD+ E++R +++D K +L L+ EL
Sbjct: 1503 LTVQREQIREPEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 999 DE---ECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESL-SNTPVSN 1053
+E + E + +K+ E Q + + A L + +++ S + A QI L S++ V
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKL 1080
+ Q +QI ++ ++ + L
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHL 1649
Score = 48.0 bits (109), Expect = 2e-04
Identities = 58/273 (21%), Positives = 120/273 (43%), Gaps = 12/273 (4%)
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
L++++ ++ L D + ++ E + L + E+ ++ + ++ SLE ++ L E
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 893 IRTQQPVERQAKFADVAVNTDEDWA-----NLHSVVVDRMSYDAEVEKNKRLMKTIEE-L 946
+ + Q R+A+ + + + NL + V + E +EE L
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
R + LK +++ E+ ++ E K + + + L L Q E +EE ET
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 1007 EYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL-EKQIESLS--NTPVSNSTMYV--ATG 1061
+++ E+Q + K A L + K NQ+V L ++QI+ L + + + M V
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 1062 SAIVQNQQITDVMKENQKLKK-MNAKLITICKK 1093
VQ +QI + K+ + + + +L+ + KK
Sbjct: 1502 KLTVQREQIREPEKDRETQRNVLEHQLLELEKK 1534
Score = 45.2 bits (102), Expect = 0.001
Identities = 77/424 (18%), Positives = 159/424 (37%), Gaps = 18/424 (4%)
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
EK A +++ +++L+ Q + ++ T+L+ L + + DY+ +K L + E +
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
T+ E ++ + + + + +
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGLENSLELESSIF 376
Query: 810 ENPKLDDSPK-----RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
D+ K RS+ V L+++L CQ+ ++ L++++ + ++E + +
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR 436
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
LQ+ + L + + L+ +V +L ++ Q + + + V E W L V V
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR-QQLEVLEQEAW-RLRRVNV 494
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ + K + EEL ++ + + K ++ E R+ LE
Sbjct: 495 ELQLQGDSAQGQKEEQQ--EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESI 552
Query: 985 KAELEELKQRYKELD---EECETCAEYLKQREEQCKR----LKEAKIALEIVDK-LSNQK 1036
E E L+Q E+ E L E K L+ A + L +++ L+ K
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 1037 VALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRG 1095
V L +Q+ L S S M A + + + K + L + N L +K
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 1096 KTGA 1099
+ GA
Sbjct: 673 EAGA 676
Score = 41.5 bits (93), Expect = 0.016
Identities = 31/120 (25%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Query: 33 KNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE-QKSAL 91
K D +IE+Q ++ +T+ C + L+E+ +++ + +KL EL +E Q+ AL
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLEC-LALELEENHHKMECQ-QKLIKELEGQRETQRVAL 1590
Query: 92 EGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLS 151
+L +Q SQI LE + +E++ +K++ ++I ELQ + + L+
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Score = 40.3 bits (90), Expect = 0.037
Identities = 171/970 (17%), Positives = 358/970 (36%), Gaps = 77/970 (7%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + E+ + + S EL +K Q + + Q+ + E L + + + +N
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE------LSALLTQSQKQNEDY 302
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
+K IK L ++++ EL E +LS E + K++ + +
Sbjct: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
LE + E E+ I + L++S+ + L + ++ +
Sbjct: 363 SGLENSL-ELESSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL--- 418
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
LQ + D E+ K L + + + T+DL ++ ++ K E+
Sbjct: 419 --LQQQHDQWEEEGKALRQRLQKLTGERDTLA-GQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 303 KRNLNSLSEQL-----INNESKKSKDHIDRYKDSL-----LAVLDAEFGTTSLDVFEILM 352
++ L L ++ +N E + D K+ LAV + E L E
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQ 535
Query: 353 DNIINKYQIDLDEILEKYTKVQGDL-----NECTSELKSVNEKLASLNSQLIEKENACNI 407
+++ I L E LE ++G+L E T+ L + +A L+S +
Sbjct: 536 SESLSEL-ITLREALESI-HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI--DIPRDLDQDLP-AHKK 464
LR ++ ++ A+ +D V +L ++ + S+++ L DL A K+
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR 653
Query: 465 ITILFDA---LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
L++ L Q + + + LR + + LE+
Sbjct: 654 REALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
H E K E L + + K + L E AL++ + E L+ + L
Sbjct: 714 HQEAKRQEEVLARAVQEK-----------EALVREKAALEVRLQAVERDRQDLAAQLQGL 762
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI--LM 639
+ + E S+ D + E Q + ++ +VI Q K++ D
Sbjct: 763 SSAKELLESSLFEAQQQNSVIDEPQGQLEVQIQTVTQAKEVI-QGEVRCLKLELDTERSQ 821
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
E K+ LEQ A E+ E+N + EK + ++
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEK-----------EVN-QLREKWEKERSWH 869
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
L K ++ ++ +E E +L E + EA++ + ES+ + QL T+K+
Sbjct: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM-QLETEKE-- 926
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDSP 818
R++ LE+ ++T++ T G L E + L ++
Sbjct: 927 --RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 819 KRSISVIS--DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
++ ++ E S L + + Q++++DLK + DD + +QE+ +
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYN 1044
Query: 877 KEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN 936
+ + LE++ ++L + ++ +R + ++ + L + + E+
Sbjct: 1045 RIQKELEREKASLTLSLMEKE--QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102
Query: 937 KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
L++ +E++ K+ D ++ + +E +++ R L +A+ +L R +
Sbjct: 1103 MELLR--QEVKEKEADFLAQEAQLLEELEASHITEQQL---RASLWAQEAKAAQLHLRLR 1157
Query: 997 ELDEECETCA 1006
+ + E A
Sbjct: 1158 STESQLEALA 1167
Score = 33.5 bits (73), Expect = 4.3
Identities = 51/252 (20%), Positives = 104/252 (41%), Gaps = 17/252 (6%)
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
T G ++R+ + ++D + ++ ++ +L++ QEL LK + D E
Sbjct: 224 TVGAQSREPNGSGRMDGREPAQLLLLL-AKTQELEKEAHERSQELIQLKSQG---DLEKA 279
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP--VERQAKFADVAVNTDEDWA 917
+ + E + +K+ E+ + L+E + + E A ++ N E+
Sbjct: 280 ELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKL 339
Query: 918 NLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK 977
+L V+ D E N +E +L++++ + Y DK
Sbjct: 340 SLQQVIKDITQVMVEEGDNIAQGSGLEN----SLELESSIF----SQFDYQDADKALTLV 391
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE--AKIALEIVDKLSNQ 1035
R L + +++L+Q+ E + Q EE+ K L++ K+ E D L+ Q
Sbjct: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQ 450
Query: 1036 KVALEKQIESLS 1047
V L+ +++SLS
Sbjct: 451 TVDLQGEVDSLS 462
>Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9,
non-muscle protein.
Length = 1960
Score = 88.6 bits (210), Expect = 1e-16
Identities = 189/1054 (17%), Positives = 430/1054 (40%), Gaps = 77/1054 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E + Q+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 98 LILETQTRDLLMSQIKS-LEMENLTKDK-EIKNLTDSLKTKSKKINE-----------LQ 144
L E + + +++ LE E + K +++ +T + K KK+ E L
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLA 991
Query: 145 EENDTLSNLIME---NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+E L + I E N+TE + +K + LK +E + DLE+ + E +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQ------ 1042
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
+ + ++ + +++L I++ K LQ+ L E+ +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-KKEEELQAALARVEEEAAQKNM 1101
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
I+ LE + DL+ + N+ E + + E++ L + L + +++
Sbjct: 1102 ALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 322 -KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + L L+ E T + E+ + ++ +L E LE+ +V+ +L +
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH--SQAVEELAEQLEQTKRVKANLEKA 1218
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
L++ +LA+ L++ + E + A ++ K NE + + T+
Sbjct: 1219 KQTLENERGELANEVKVLLQGKG-------DSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 441 CLKLSKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIE-KEKLRLETGT 496
K++KL++++ L Q K+T F AL +Q + ++ + E ++KL L T
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST-K 1330
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
K V + ++ +LH ++ + K K++++ L + + +
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM-KKKMEDSVGCLETAEEVKRK 1389
Query: 557 IDA-LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ L+ ++EEK+ + + + T L ++ L + + + + ++++
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
L + + E D+ +A+ ++ L N + + E+
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRD 734
+ ++ EK+ + + ++ Q++E +D+L ++ KL L +A+K
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL-RLEVNLQAMKAQ 1568
Query: 735 YDAAVKDL-ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
++ ++ E S E QL Q +E AELE D R +++ V
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREME---AELE-DERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 794 XXXXXXTFGDEN----RDLGENPK-----LDDSPKRSISVI-----SDSEVSQLKERLLS 839
DE R L K LDD+ ++ ++ ++ ++ ++
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP- 898
Q+EL + ++ E + A+ + + A +EK LE +++ L+E++ +Q
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 899 ---VERQAKFADV---AVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR-YKKQ 951
+ + K A++ +NTD + H+ + E +NK L ++E+ K
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE-RQNKELKVKLQEMEGTVKS 1803
Query: 952 DLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
K ++T ++ K + + D E + ++ + + ++LK ++D+E +Y
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
Q ++ RLK+ K LE ++ + + A ++++
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Score = 72.1 bits (169), Expect = 1e-11
Identities = 150/703 (21%), Positives = 295/703 (41%), Gaps = 57/703 (8%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL V EK + ++L E E + L +K ++ E A T ++ + EL+ LT +
Sbjct: 853 ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET-ELCAEAEELRARLTAKKQ 911
Query: 443 KLSKLKIDIPRDLDQD------LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
+L ++ D+ ++++ L A KK I + E + E ++KL+LE T
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKK---KMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
+A D + E K L + + + + +E + +L K+ ++
Sbjct: 969 TEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH 1025
Query: 557 ---IDALKIAIAKNEEKMLSLSEKDNKL----TELVSTINGLKEENNSLKSLNDVITREK 609
I L+ + + E++ L + KL T+L I L+ + LK + +E+
Sbjct: 1026 EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM--QLAKKEE 1083
Query: 610 ETQASELERSCQVIKQNGFELDKMK---ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
E QA+ L R + Q L K++ + I + + L E+
Sbjct: 1084 ELQAA-LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 667 ALKEQCEEKTRDCSRLEINIKT-HEKTAEIQNRMIMRLQK----QIQEDDKLFIEKETKL 721
ALK + E+ T D + + +++ E+ I + + K QIQE + + +L
Sbjct: 1143 ALKTELED-TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 722 NELTNKYEALKRDYDAAVKDLESSR-EAVNQLTTQKDLVEGRIAELESDIRTE---QTAT 777
E + + +K + + A + LE+ R E N++ K L++G+ + E Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEV---KVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V + L ++ + S + +S++ +E L
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-ESQLQDTQELL 1317
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ 897
++ L + K+++DE + E L+E +E L+K+ +L QV+++K+++
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIE----ELRYKKQD 952
A+ +V +D L ++++ ++EK K RL + ++ +L +++Q
Sbjct: 1378 GCLETAE--EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELED-CKAELEELKQR----YKELDEECETCAE 1007
N + K QK ++ ++K AK E D +AE E + + + L+E E AE
Sbjct: 1436 ACN-LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
Query: 1008 ---YLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQIESL 1046
KQ + + L +K + + V +L K ALE+Q+E +
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Score = 62.5 bits (145), Expect = 8e-09
Identities = 154/886 (17%), Positives = 347/886 (39%), Gaps = 65/886 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILE-TQTRDLLMSQIKSLEMENLTK 122
++ E+ KL G+ D+ +Q + L+ + L ++ + + L + + +E E K
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
+ +K + + +I+ELQE+ ++ + + +L +E++ LK E
Sbjct: 1100 NMALKKIREL----ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 183 IDLEKLVNESENKIG--PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN-TSTRY 239
++L ++ E ++ K + + K E IQ + + + +L + +
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 240 NKIC-TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K TL++E + K L + ++ + E + +L K E T+
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL-QELQVKFNEGERVRTELADK 1274
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+++++ L++++ L ++SK SK KD + L+++ T E+L + K
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSK----LTKD--FSALESQLQDTQ----ELLQEENRQK 1324
Query: 359 YQID--LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ L ++ ++ + L E ++ +++A+L++Q+ + + E
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 417 EISSAVTIDI--VKKENELK----EILTKECLKLSKLKIDIPRDLDQDLPAH---KKITI 467
E+ + D+ + + +E K + L K +L + D+ DLD + +K
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
FD L+ + + Y E+++ E A+ + E K
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAE---AREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 528 LHEELTKLYKSKVDENNANLNLIK---ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
E+ L SK D + L K L ++++ +K + + E+++ + +D KL L
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT--EDAKL-RL 1558
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQ----ASELERSCQVIKQNGFELDKMKADILMX 640
+ +K + D + EK+ Q E+E + ++ + + M
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD--CSRLEI--NIKTHEKTAEIQ 696
DEA L + A + C + D SR EI K +EK +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK 756
+++LQ+++ ++ + + + +EL ++ A+++ + QL +
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK--- 813
+ +G + ++ +N++L +
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1798
Query: 814 --LDDSPKRSISVISDSEVSQL--------KERLLSCQQEL---DDLKERYKELDDECET 860
+ K SI+ + +++++QL KER +C+Q LK+ ++DDE
Sbjct: 1799 GTVKSKYKASITAL-EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+Y + D+ RLK+ K LE+ + +++ ++R+ + A
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 56.0 bits (129), Expect = 7e-07
Identities = 50/234 (21%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 828 SEVSQLKERLLSCQQ---ELDDLKERY----KELDDECETCAEYLQERDEQCARLKKEKL 880
+E QL+E+L + + E ++L+ R +EL++ C ++E +E+C L+ EK
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
++Q + L+EQ+ ++ ++ + V T+ L + + ++ K K+L+
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLE--KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 941 K-TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK--- 996
+ I E + + + K K+ + E + + E + ELE+ +++ +
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 997 -EL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+L D+ E A+ + + + K+ +E + AL V++ + QK K+I L +
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Score = 50.0 bits (114), Expect = 5e-05
Identities = 57/245 (23%), Positives = 106/245 (43%), Gaps = 16/245 (6%)
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
P L S + + + E+ +++E+ L+ + L +++ +L E E LQ E
Sbjct: 836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 872 CA-------RLKKEKLSLEQQVSNLKEQIRTQQP--VERQAKFADVAVNTDEDWANLHSV 922
CA RL +K LE+ +L+ ++ ++ QA+ + N E L
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R E + +K +EE + +D + K +K +E + EF E E
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAEFTTNLTEEE 1012
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEK 1041
+ L +LK +++ + + E E L++ E+Q + L++ + LE LS+Q L+
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 1042 QIESL 1046
QI L
Sbjct: 1070 QIAEL 1074
Score = 50.0 bits (114), Expect = 5e-05
Identities = 116/685 (16%), Positives = 279/685 (40%), Gaps = 58/685 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ-TRDLLMSQIKSLEMENLT 121
L + ++ ++L+ ++G L + S L + L + Q T++LL + + + L+
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR----QKLS 1326
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNEC 177
++K + D + +++ E +E L I + ++ K+++D L+ E
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTS 236
+ DLE L E K+ + + K + + + L + D+ + + +
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH---QRQSACNLEKKQ 1443
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE----NNEFE 292
+++++ + + A + ++ E K L + E+ E N +F
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 293 TKAVKVMS---EIKRNLNSL--SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV 347
T+ +MS ++ ++++ L S++ + + ++ K ++ +D L A DA+
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR------ 1557
Query: 348 FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI 407
E+ + + +++ DL E+ + + L E+++ E S +
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE- 1616
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLK-LSKLKIDIPRDLDQDLPAHKKIT 466
+ ++ H S+ D K+ + K+C++ L + L Q KK+
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 467 ILFDALIT-QYELS---RTDYEIEKEKLRL------ETGTAKAVXXXXXXXXXXXXXXFD 516
+ +I Q EL+ R + ++E+ L +G +
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE 1736
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK-NEEKMLSLS 575
LEE + +++ L K ++D+ N +LNL + +++ + + + + N+E + L
Sbjct: 1737 ELEEEQGNTELINDRLKKA-NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 576 EKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E + + ++ ++I L+ + L+ D T+E++ ++ R+ +K
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT-----------EKKL 1844
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS----RLEINIKTHE 690
D+L+ D+A + L+Q E+ EE+ + + +L+ ++
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFI 715
+TA+ NR + L+ +++ D F+
Sbjct: 1905 ETADAMNREVSSLKNKLRRGDLPFV 1929
Score = 49.2 bits (112), Expect = 8e-05
Identities = 76/387 (19%), Positives = 169/387 (43%), Gaps = 35/387 (9%)
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L+++ + E A+ + + +R +KQ+ +++L E ET ++L + L+ A +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVR-EKQLAAENRL-TEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ E +LT +K +E +LE+ + E+
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERC--------------QHLQAEKKKM 941
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
++L E + ++S ++ + V +++++ +L+E + + + L + K L+D
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ----QPVER-QAKFADVAVNTD 913
L E +E+ L K K E +++L+E++R + Q +E+ + K + +
Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+ A L + + + +M + E+ + + +EE +K + +++ + + + +
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 973 EFEAKRKELEDCKAEL-EELKQRYKELDEECETCA---EYLKQREEQCKRLK-----EAK 1023
A R + E K +L EEL+ EL++ ++ A E +RE++ LK EAK
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 1024 I-ALEIVDKLSNQKVALEKQIESLSNT 1049
+I + A+E+ E L T
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQT 1208
Score = 39.5 bits (88), Expect = 0.065
Identities = 37/180 (20%), Positives = 78/180 (43%), Gaps = 6/180 (3%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N +T+M+ + + + +
Sbjct: 827 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVD 1030
+ + + AE EEL+ R +EL+E C +++ EE+C+ L+ E K + +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 1031 KLSNQKVALEKQIESLSNTPV-SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+L Q E + L V + + + I+ Q + KE + L+ A+ T
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
>M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle
myosin heavy chain (NMHC) mRNA, 3' end. ).
Length = 1247
Score = 88.6 bits (210), Expect = 1e-16
Identities = 186/1054 (17%), Positives = 425/1054 (40%), Gaps = 76/1054 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E +YQ+
Sbjct: 160 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERYQH 219
Query: 98 LILETQTRDLLMSQIKS-LEMENLTKDK-EIKNLTDSLKTKSKKINE-----------LQ 144
L E + + +++ LE E + K +++ +T + K KK+ E L
Sbjct: 220 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLA 277
Query: 145 EENDTLSNLIME---NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+E L + I E N+TE + +K + LK +E + DLE+ + E +
Sbjct: 278 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQ------ 328
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
+ + ++ + +++L I++ K LQ+ L E+ +
Sbjct: 329 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-KKEEELQAALARVEEEAAQKNM 387
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
I+ LE + DL+ + N+ E + + E++ L + L + +++
Sbjct: 388 ALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 446
Query: 322 -KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + L L+ E T + E+ + ++ +L E LE+ +V+ +L +
Sbjct: 447 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH--SQAVEELAEQLEQTKRVKANLEKA 504
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
L++ +LA+ L++ E + A ++ K NE + + T+
Sbjct: 505 KQTLENERGELANEVKVLLQGGR-------DSEHKRKKVEAQLQELQVKFNEGERVRTEL 557
Query: 441 CLKLSKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIE-KEKLRLETGT 496
K++KL++++ L Q K+T F AL +Q + ++ + E ++KL L T
Sbjct: 558 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 617
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
+ + ++ +LH ++ + K K++++ L + + +
Sbjct: 618 KQVEDEKNSFREQLEEEEEEAKHNLEKQIATLHAQVADM-KKKMEDSVGCLETAEEVKRK 676
Query: 557 IDA-LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ L+ ++EEK+ + + + T L ++ L + + + + ++++
Sbjct: 677 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 736
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
L + + E D+ +A+ ++ L N + + E+
Sbjct: 737 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 796
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRD 734
+ ++ EK+ + + ++ Q++E +D+L ++ KL L +A+K
Sbjct: 797 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL-RLEVNLQAMKAQ 855
Query: 735 YDAAVKDL-ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
++ ++ E S E QL Q +E AELE D R +++ V
Sbjct: 856 FERDLQGRDEQSEEKKKQLVRQVREME---AELE-DERKQRSMAVAARKKLEMDLKDLEA 911
Query: 794 XXXXXXTFGDEN----RDLGENPK-----LDDSPKRSISVI-----SDSEVSQLKERLLS 839
DE R L K LDD+ ++ ++ ++ ++ ++
Sbjct: 912 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 971
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
Q+EL + ++ E + A+ + + A +EK LE +++ L+E++ +Q
Sbjct: 972 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1031
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
N D N + ++R ++L + +EL+ K Q+++ TV
Sbjct: 1032 TELINDRLKKANLQIDQINA-DLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1090
Query: 960 MQKAM-----EKYTKKDKEFEAKRKELEDCKAELEELKQRYK----ELDEECETCAEYLK 1010
KA K + +++ + + KE + ++ +++ K ++D+E +Y
Sbjct: 1091 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1150
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
Q ++ RLK+ K LE ++ + + A ++++
Sbjct: 1151 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1184
Score = 63.3 bits (147), Expect = 5e-09
Identities = 156/887 (17%), Positives = 349/887 (39%), Gaps = 66/887 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILE-TQTRDLLMSQIKSLEMENLTK 122
++ E+ KL G+ D+ +Q + L+ + L ++ + + L + + +E E K
Sbjct: 326 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 385
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
+ +K + + +I+ELQE+ ++ + + +L +E++ LK E
Sbjct: 386 NMALKKIREL----ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 441
Query: 183 IDLEKLVNESENKIG--PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN-TSTRY 239
++L ++ E ++ K + + K E IQ + + + +L + +
Sbjct: 442 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 501
Query: 240 NKIC-TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K TL++E + K L + ++ + E + +L K E T+
Sbjct: 502 EKAKQTLENERGELANEVKVLLQGGRDSEHKRKKVEAQL-QELQVKFNEGERVRTELADK 560
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+++++ L++++ L ++SK SK KD + L+++ T E+L + K
Sbjct: 561 VTKLQVELDNVTGLLSQSDSKSSK----LTKD--FSALESQLQDTQ----ELLQEENRQK 610
Query: 359 YQID--LDEILEKYTKVQGDLNECTSELK-SVNEKLASLNSQLIEKENACNILRIQKERI 415
+ L ++ ++ + L E E K ++ +++A+L++Q+ + + E
Sbjct: 611 LSLSTKLKQVEDEKNSFREQLEEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 670
Query: 416 HEISSAVTIDI--VKKENELK----EILTKECLKLSKLKIDIPRDLDQDLPAH---KKIT 466
E+ + D+ + + +E K + L K +L + D+ DLD + +K
Sbjct: 671 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 730
Query: 467 ILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
FD L+ + + Y E+++ E A+ + E K
Sbjct: 731 KKFDQLLAEEKTISAKYAEERDRAEAE---AREKETKALSLARALEEAMEQKAELERLNK 787
Query: 527 SLHEELTKLYKSKVDENNANLNLIK---ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E+ L SK D + L K L ++++ +K + + E+++ + +D KL
Sbjct: 788 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT--EDAKL-R 844
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQ----ASELERSCQVIKQNGFELDKMKADILM 639
L + +K + D + EK+ Q E+E + ++ + + M
Sbjct: 845 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 904
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD--CSRLEI--NIKTHEKTAEI 695
DEA L + A + C + D SR EI K +EK +
Sbjct: 905 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 964
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
+++LQ+++ ++ + + + +EL ++ A+++ + QL +
Sbjct: 965 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1024
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-- 813
+ +G + ++ +N++L +
Sbjct: 1025 LEEEQGNTELINDRLKKANLQIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEM 1084
Query: 814 ---LDDSPKRSISVISDSEVSQL--------KERLLSCQQEL---DDLKERYKELDDECE 859
+ K SI+ + +++++QL KER +C+Q LK+ ++DDE
Sbjct: 1085 EGTVKSKYKASITAL-EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERR 1143
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+Y + D+ RLK+ K LE+ + +++ ++R+ + A
Sbjct: 1144 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1190
Score = 51.6 bits (118), Expect = 2e-05
Identities = 49/234 (20%), Positives = 110/234 (47%), Gaps = 15/234 (6%)
Query: 828 SEVSQLKERLLSCQQ---ELDDLKERY----KELDDECETCAEYLQERDEQCARLKKEKL 880
+E QL+E+L + + E ++L+ R +EL++ C ++E +E+ L+ EK
Sbjct: 166 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKK 225
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
++Q + L+EQ+ ++ ++ + V T+ L + + ++ K K+L+
Sbjct: 226 KMQQNIQELEEQLEEEESARQKLQLE--KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 283
Query: 941 K-TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK--- 996
+ I E + + + K K+ + E + + E + ELE+ +++ +
Sbjct: 284 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 343
Query: 997 -EL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+L D+ E A+ + + + K+ +E + AL V++ + QK K+I L +
Sbjct: 344 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 397
Score = 50.0 bits (114), Expect = 5e-05
Identities = 76/387 (19%), Positives = 170/387 (43%), Gaps = 35/387 (9%)
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L+++ + E A+ + + +R +KQ+ +++L +E ET ++L + L+ A +
Sbjct: 124 LQVSRQEEEMMAKEEELVKVR-EKQLAAENRL-MEMETLQSQLMAEKLQLQEQLQAETEL 181
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ E +LT +K +E +LE+ + E+
Sbjct: 182 CAEAEELRARLTAKKQELEEICHDLEARVEEEEER--------------YQHLQAEKKKM 227
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
++L E + ++S ++ + V +++++ +L+E + + + L + K L+D
Sbjct: 228 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 287
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ----QPVER-QAKFADVAVNTD 913
L E +E+ L K K E +++L+E++R + Q +E+ + K + +
Sbjct: 288 AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 347
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+ A L + + + +M + E+ + + +EE +K + +++ + + + +
Sbjct: 348 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 407
Query: 973 EFEAKRKELEDCKAEL-EELKQRYKELDEECETCA---EYLKQREEQCKRLK-----EAK 1023
A R + E K +L EEL+ EL++ ++ A E +RE++ LK EAK
Sbjct: 408 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 467
Query: 1024 I-ALEIVDKLSNQKVALEKQIESLSNT 1049
+I + A+E+ E L T
Sbjct: 468 THEAQIQEMRQKHSQAVEELAEQLEQT 494
Score = 49.6 bits (113), Expect = 6e-05
Identities = 116/684 (16%), Positives = 279/684 (40%), Gaps = 55/684 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + ++ ++L+ ++G L + S L + L + Q L+ + ++ TK
Sbjct: 557 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 616
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNECL 178
K++++ +S + + ++ E +E L I + ++ K+++D L+ E
Sbjct: 617 LKQVEDEKNSFREQLEE--EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 674
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTST 237
+ DLE L E K+ + + K + + + L + D+ + + +
Sbjct: 675 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH---QRQSACNLEKKQK 731
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE----NNEFET 293
+++++ + + A + ++ E K L + E+ E N +F T
Sbjct: 732 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 791
Query: 294 KAVKVMS---EIKRNLNSL--SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ +MS ++ ++++ L S++ + + ++ K ++ +D L A DA+
Sbjct: 792 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR------L 845
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
E+ + + +++ DL E+ + + L E+++ E S + +
Sbjct: 846 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE-M 904
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLK-LSKLKIDIPRDLDQDLPAHKKITI 467
++ H S+ D K+ + K+C++ L + L Q KK+
Sbjct: 905 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 964
Query: 468 LFDALIT-QYELS---RTDYEIEKEKLRL------ETGTAKAVXXXXXXXXXXXXXXFDT 517
+ +I Q EL+ R + ++E+ L +G +
Sbjct: 965 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1024
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK-NEEKMLSLSE 576
LEE + +++ L K ++D+ NA+LNL + +++ + + + + N+E + L E
Sbjct: 1025 LEEEQGNTELINDRLKKA-NLQIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQE 1083
Query: 577 KDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
+ + ++ ++I L+ + L+ D T+E++ ++ R+ +K
Sbjct: 1084 MEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT-----------EKKLK 1132
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS----RLEINIKTHEK 691
D+L+ D+A + L+Q E+ EE+ + + +L+ ++ +
Sbjct: 1133 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1192
Query: 692 TAEIQNRMIMRLQKQIQEDDKLFI 715
TA+ NR + L+ +++ D F+
Sbjct: 1193 TADAMNREVSSLKNKLRRGDLPFV 1216
Score = 49.2 bits (112), Expect = 8e-05
Identities = 57/245 (23%), Positives = 106/245 (43%), Gaps = 16/245 (6%)
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
P L S + + + E+ +++E+ L+ + L +++ +L E E LQ E
Sbjct: 122 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLMEMETLQSQLMAEKLQLQEQLQAETEL 181
Query: 872 CA-------RLKKEKLSLEQQVSNLKEQIRTQQP--VERQAKFADVAVNTDEDWANLHSV 922
CA RL +K LE+ +L+ ++ ++ QA+ + N E L
Sbjct: 182 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQLEEE 241
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R E + +K +EE + +D + K +K +E + EF E E
Sbjct: 242 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAEFTTNLTEEE 298
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEK 1041
+ L +LK +++ + + E E L++ E+Q + L++ + LE LS+Q L+
Sbjct: 299 EKSKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 355
Query: 1042 QIESL 1046
QI L
Sbjct: 356 QIAEL 360
Score = 32.7 bits (71), Expect = 7.5
Identities = 35/180 (19%), Positives = 76/180 (42%), Gaps = 6/180 (3%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N + +M+ + + + +
Sbjct: 113 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLMEMETLQSQLMAEKLQLQ 172
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVD 1030
+ + + AE EEL+ R +EL+E C +++ EE+ + L+ E K + +
Sbjct: 173 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQ 232
Query: 1031 KLSNQKVALEKQIESLSNTPV-SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+L Q E + L V + + + I+ Q + KE + L+ A+ T
Sbjct: 233 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 292
>CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein.
Length = 1960
Score = 88.6 bits (210), Expect = 1e-16
Identities = 189/1054 (17%), Positives = 430/1054 (40%), Gaps = 77/1054 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E + Q+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 98 LILETQTRDLLMSQIKS-LEMENLTKDK-EIKNLTDSLKTKSKKINE-----------LQ 144
L E + + +++ LE E + K +++ +T + K KK+ E L
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLA 991
Query: 145 EENDTLSNLIME---NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+E L + I E N+TE + +K + LK +E + DLE+ + E +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQ------ 1042
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
+ + ++ + +++L I++ K LQ+ L E+ +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-KKEEELQAALARVEEEAAQKNM 1101
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
I+ LE + DL+ + N+ E + + E++ L + L + +++
Sbjct: 1102 ALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 322 -KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + L L+ E T + E+ + ++ +L E LE+ +V+ +L +
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH--SQAVEELAEQLEQTKRVKANLEKA 1218
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
L++ +LA+ L++ + E + A ++ K NE + + T+
Sbjct: 1219 KQTLENERGELANEVKVLLQGKG-------DSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 441 CLKLSKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIE-KEKLRLETGT 496
K++KL++++ L Q K+T F AL +Q + ++ + E ++KL L T
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST-K 1330
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
K V + ++ +LH ++ + K K++++ L + + +
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM-KKKMEDSVGCLETAEEVKRK 1389
Query: 557 IDA-LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ L+ ++EEK+ + + + T L ++ L + + + + ++++
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
L + + E D+ +A+ ++ L N + + E+
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRD 734
+ ++ EK+ + + ++ Q++E +D+L ++ KL L +A+K
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL-RLEVNLQAMKAQ 1568
Query: 735 YDAAVKDL-ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
++ ++ E S E QL Q +E AELE D R +++ V
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREME---AELE-DERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 794 XXXXXXTFGDEN----RDLGENPK-----LDDSPKRSISVI-----SDSEVSQLKERLLS 839
DE R L K LDD+ ++ ++ ++ ++ ++
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP- 898
Q+EL + ++ E + A+ + + A +EK LE +++ L+E++ +Q
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 899 ---VERQAKFADV---AVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR-YKKQ 951
+ + K A++ +NTD + H+ + E +NK L ++E+ K
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE-RQNKELKVKLQEMEGTVKS 1803
Query: 952 DLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
K ++T ++ K + + D E + ++ + + ++LK ++D+E +Y
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
Q ++ RLK+ K LE ++ + + A ++++
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Score = 72.1 bits (169), Expect = 1e-11
Identities = 150/703 (21%), Positives = 295/703 (41%), Gaps = 57/703 (8%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL V EK + ++L E E + L +K ++ E A T ++ + EL+ LT +
Sbjct: 853 ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET-ELCAEAEELRARLTAKKQ 911
Query: 443 KLSKLKIDIPRDLDQD------LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
+L ++ D+ ++++ L A KK I + E + E ++KL+LE T
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKK---KMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
+A D + E K L + + + + +E + +L K+ ++
Sbjct: 969 TEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH 1025
Query: 557 ---IDALKIAIAKNEEKMLSLSEKDNKL----TELVSTINGLKEENNSLKSLNDVITREK 609
I L+ + + E++ L + KL T+L I L+ + LK + +E+
Sbjct: 1026 EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM--QLAKKEE 1083
Query: 610 ETQASELERSCQVIKQNGFELDKMK---ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
E QA+ L R + Q L K++ + I + + L E+
Sbjct: 1084 ELQAA-LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 667 ALKEQCEEKTRDCSRLEINIKT-HEKTAEIQNRMIMRLQK----QIQEDDKLFIEKETKL 721
ALK + E+ T D + + +++ E+ I + + K QIQE + + +L
Sbjct: 1143 ALKTELED-TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 722 NELTNKYEALKRDYDAAVKDLESSR-EAVNQLTTQKDLVEGRIAELESDIRTE---QTAT 777
E + + +K + + A + LE+ R E N++ K L++G+ + E Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEV---KVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V + L ++ + S + +S++ +E L
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-ESQLQDTQELL 1317
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ 897
++ L + K+++DE + E L+E +E L+K+ +L QV+++K+++
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIE----ELRYKKQD 952
A+ +V +D L ++++ ++EK K RL + ++ +L +++Q
Sbjct: 1378 GCLETAE--EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELED-CKAELEELKQR----YKELDEECETCAE 1007
N + K QK ++ ++K AK E D +AE E + + + L+E E AE
Sbjct: 1436 ACN-LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
Query: 1008 ---YLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQIESL 1046
KQ + + L +K + + V +L K ALE+Q+E +
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Score = 62.5 bits (145), Expect = 8e-09
Identities = 154/886 (17%), Positives = 347/886 (39%), Gaps = 65/886 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILE-TQTRDLLMSQIKSLEMENLTK 122
++ E+ KL G+ D+ +Q + L+ + L ++ + + L + + +E E K
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
+ +K + + +I+ELQE+ ++ + + +L +E++ LK E
Sbjct: 1100 NMALKKIREL----ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 183 IDLEKLVNESENKIG--PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN-TSTRY 239
++L ++ E ++ K + + K E IQ + + + +L + +
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 240 NKIC-TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K TL++E + K L + ++ + E + +L K E T+
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL-QELQVKFNEGERVRTELADK 1274
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+++++ L++++ L ++SK SK KD + L+++ T E+L + K
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSK----LTKD--FSALESQLQDTQ----ELLQEENRQK 1324
Query: 359 YQID--LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ L ++ ++ + L E ++ +++A+L++Q+ + + E
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 417 EISSAVTIDI--VKKENELK----EILTKECLKLSKLKIDIPRDLDQDLPAH---KKITI 467
E+ + D+ + + +E K + L K +L + D+ DLD + +K
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
FD L+ + + Y E+++ E A+ + E K
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAE---AREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 528 LHEELTKLYKSKVDENNANLNLIK---ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
E+ L SK D + L K L ++++ +K + + E+++ + +D KL L
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT--EDAKL-RL 1558
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQ----ASELERSCQVIKQNGFELDKMKADILMX 640
+ +K + D + EK+ Q E+E + ++ + + M
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD--CSRLEI--NIKTHEKTAEIQ 696
DEA L + A + C + D SR EI K +EK +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK 756
+++LQ+++ ++ + + + +EL ++ A+++ + QL +
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK--- 813
+ +G + ++ +N++L +
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1798
Query: 814 --LDDSPKRSISVISDSEVSQL--------KERLLSCQQEL---DDLKERYKELDDECET 860
+ K SI+ + +++++QL KER +C+Q LK+ ++DDE
Sbjct: 1799 GTVKSKYKASITAL-EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+Y + D+ RLK+ K LE+ + +++ ++R+ + A
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 56.0 bits (129), Expect = 7e-07
Identities = 50/234 (21%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 828 SEVSQLKERLLSCQQ---ELDDLKERY----KELDDECETCAEYLQERDEQCARLKKEKL 880
+E QL+E+L + + E ++L+ R +EL++ C ++E +E+C L+ EK
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
++Q + L+EQ+ ++ ++ + V T+ L + + ++ K K+L+
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLE--KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 941 K-TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK--- 996
+ I E + + + K K+ + E + + E + ELE+ +++ +
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 997 -EL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+L D+ E A+ + + + K+ +E + AL V++ + QK K+I L +
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Score = 50.0 bits (114), Expect = 5e-05
Identities = 57/245 (23%), Positives = 106/245 (43%), Gaps = 16/245 (6%)
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
P L S + + + E+ +++E+ L+ + L +++ +L E E LQ E
Sbjct: 836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 872 CA-------RLKKEKLSLEQQVSNLKEQIRTQQP--VERQAKFADVAVNTDEDWANLHSV 922
CA RL +K LE+ +L+ ++ ++ QA+ + N E L
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R E + +K +EE + +D + K +K +E + EF E E
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAEFTTNLTEEE 1012
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEK 1041
+ L +LK +++ + + E E L++ E+Q + L++ + LE LS+Q L+
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 1042 QIESL 1046
QI L
Sbjct: 1070 QIAEL 1074
Score = 50.0 bits (114), Expect = 5e-05
Identities = 116/685 (16%), Positives = 279/685 (40%), Gaps = 58/685 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ-TRDLLMSQIKSLEMENLT 121
L + ++ ++L+ ++G L + S L + L + Q T++LL + + + L+
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR----QKLS 1326
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNEC 177
++K + D + +++ E +E L I + ++ K+++D L+ E
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTS 236
+ DLE L E K+ + + K + + + L + D+ + + +
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH---QRQSACNLEKKQ 1443
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE----NNEFE 292
+++++ + + A + ++ E K L + E+ E N +F
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 293 TKAVKVMS---EIKRNLNSL--SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV 347
T+ +MS ++ ++++ L S++ + + ++ K ++ +D L A DA+
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR------ 1557
Query: 348 FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI 407
E+ + + +++ DL E+ + + L E+++ E S +
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE- 1616
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLK-LSKLKIDIPRDLDQDLPAHKKIT 466
+ ++ H S+ D K+ + K+C++ L + L Q KK+
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 467 ILFDALIT-QYELS---RTDYEIEKEKLRL------ETGTAKAVXXXXXXXXXXXXXXFD 516
+ +I Q EL+ R + ++E+ L +G +
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE 1736
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK-NEEKMLSLS 575
LEE + +++ L K ++D+ N +LNL + +++ + + + + N+E + L
Sbjct: 1737 ELEEEQGNTELINDRLKKA-NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 576 EKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E + + ++ ++I L+ + L+ D T+E++ ++ R+ +K
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT-----------EKKL 1844
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS----RLEINIKTHE 690
D+L+ D+A + L+Q E+ EE+ + + +L+ ++
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFI 715
+TA+ NR + L+ +++ D F+
Sbjct: 1905 ETADAMNREVSSLKNKLRRGDLPFV 1929
Score = 49.2 bits (112), Expect = 8e-05
Identities = 76/387 (19%), Positives = 169/387 (43%), Gaps = 35/387 (9%)
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L+++ + E A+ + + +R +KQ+ +++L E ET ++L + L+ A +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVR-EKQLAAENRL-TEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ E +LT +K +E +LE+ + E+
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERC--------------QHLQAEKKKM 941
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
++L E + ++S ++ + V +++++ +L+E + + + L + K L+D
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ----QPVER-QAKFADVAVNTD 913
L E +E+ L K K E +++L+E++R + Q +E+ + K + +
Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+ A L + + + +M + E+ + + +EE +K + +++ + + + +
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 973 EFEAKRKELEDCKAEL-EELKQRYKELDEECETCA---EYLKQREEQCKRLK-----EAK 1023
A R + E K +L EEL+ EL++ ++ A E +RE++ LK EAK
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 1024 I-ALEIVDKLSNQKVALEKQIESLSNT 1049
+I + A+E+ E L T
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQT 1208
Score = 39.5 bits (88), Expect = 0.065
Identities = 37/180 (20%), Positives = 78/180 (43%), Gaps = 6/180 (3%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N +T+M+ + + + +
Sbjct: 827 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVD 1030
+ + + AE EEL+ R +EL+E C +++ EE+C+ L+ E K + +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 1031 KLSNQKVALEKQIESLSNTPV-SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+L Q E + L V + + + I+ Q + KE + L+ A+ T
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
>AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy
polypeptide 9 protein.
Length = 1960
Score = 88.6 bits (210), Expect = 1e-16
Identities = 189/1054 (17%), Positives = 430/1054 (40%), Gaps = 77/1054 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E + Q+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 98 LILETQTRDLLMSQIKS-LEMENLTKDK-EIKNLTDSLKTKSKKINE-----------LQ 144
L E + + +++ LE E + K +++ +T + K KK+ E L
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLA 991
Query: 145 EENDTLSNLIME---NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+E L + I E N+TE + +K + LK +E + DLE+ + E +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQ------ 1042
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
+ + ++ + +++L I++ K LQ+ L E+ +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-KKEEELQAALARVEEEAAQKNM 1101
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
I+ LE + DL+ + N+ E + + E++ L + L + +++
Sbjct: 1102 ALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 322 -KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + L L+ E T + E+ + ++ +L E LE+ +V+ +L +
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH--SQAVEELAEQLEQTKRVKANLEKA 1218
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
L++ +LA+ L++ + E + A ++ K NE + + T+
Sbjct: 1219 KQTLENERGELANEVKVLLQGKG-------DSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 441 CLKLSKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIE-KEKLRLETGT 496
K++KL++++ L Q K+T F AL +Q + ++ + E ++KL L T
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST-K 1330
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
K V + ++ +LH ++ + K K++++ L + + +
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM-KKKMEDSVGCLETAEEVKRK 1389
Query: 557 IDA-LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ L+ ++EEK+ + + + T L ++ L + + + + ++++
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
L + + E D+ +A+ ++ L N + + E+
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRD 734
+ ++ EK+ + + ++ Q++E +D+L ++ KL L +A+K
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL-RLEVNLQAMKAQ 1568
Query: 735 YDAAVKDL-ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
++ ++ E S E QL Q +E AELE D R +++ V
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREME---AELE-DERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 794 XXXXXXTFGDEN----RDLGENPK-----LDDSPKRSISVI-----SDSEVSQLKERLLS 839
DE R L K LDD+ ++ ++ ++ ++ ++
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP- 898
Q+EL + ++ E + A+ + + A +EK LE +++ L+E++ +Q
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 899 ---VERQAKFADV---AVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR-YKKQ 951
+ + K A++ +NTD + H+ + E +NK L ++E+ K
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE-RQNKELKVKLQEMEGTVKS 1803
Query: 952 DLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
K ++T ++ K + + D E + ++ + + ++LK ++D+E +Y
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
Q ++ RLK+ K LE ++ + + A ++++
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Score = 72.1 bits (169), Expect = 1e-11
Identities = 150/703 (21%), Positives = 295/703 (41%), Gaps = 57/703 (8%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL V EK + ++L E E + L +K ++ E A T ++ + EL+ LT +
Sbjct: 853 ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET-ELCAEAEELRARLTAKKQ 911
Query: 443 KLSKLKIDIPRDLDQD------LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
+L ++ D+ ++++ L A KK I + E + E ++KL+LE T
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKK---KMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
+A D + E K L + + + + +E + +L K+ ++
Sbjct: 969 TEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH 1025
Query: 557 ---IDALKIAIAKNEEKMLSLSEKDNKL----TELVSTINGLKEENNSLKSLNDVITREK 609
I L+ + + E++ L + KL T+L I L+ + LK + +E+
Sbjct: 1026 EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM--QLAKKEE 1083
Query: 610 ETQASELERSCQVIKQNGFELDKMK---ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
E QA+ L R + Q L K++ + I + + L E+
Sbjct: 1084 ELQAA-LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 667 ALKEQCEEKTRDCSRLEINIKT-HEKTAEIQNRMIMRLQK----QIQEDDKLFIEKETKL 721
ALK + E+ T D + + +++ E+ I + + K QIQE + + +L
Sbjct: 1143 ALKTELED-TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 722 NELTNKYEALKRDYDAAVKDLESSR-EAVNQLTTQKDLVEGRIAELESDIRTE---QTAT 777
E + + +K + + A + LE+ R E N++ K L++G+ + E Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEV---KVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V + L ++ + S + +S++ +E L
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-ESQLQDTQELL 1317
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ 897
++ L + K+++DE + E L+E +E L+K+ +L QV+++K+++
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIE----ELRYKKQD 952
A+ +V +D L ++++ ++EK K RL + ++ +L +++Q
Sbjct: 1378 GCLETAE--EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELED-CKAELEELKQR----YKELDEECETCAE 1007
N + K QK ++ ++K AK E D +AE E + + + L+E E AE
Sbjct: 1436 ACN-LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
Query: 1008 ---YLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQIESL 1046
KQ + + L +K + + V +L K ALE+Q+E +
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Score = 62.5 bits (145), Expect = 8e-09
Identities = 154/886 (17%), Positives = 347/886 (39%), Gaps = 65/886 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILE-TQTRDLLMSQIKSLEMENLTK 122
++ E+ KL G+ D+ +Q + L+ + L ++ + + L + + +E E K
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
+ +K + + +I+ELQE+ ++ + + +L +E++ LK E
Sbjct: 1100 NMALKKIREL----ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 183 IDLEKLVNESENKIG--PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN-TSTRY 239
++L ++ E ++ K + + K E IQ + + + +L + +
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 240 NKIC-TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K TL++E + K L + ++ + E + +L K E T+
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL-QELQVKFNEGERVRTELADK 1274
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+++++ L++++ L ++SK SK KD + L+++ T E+L + K
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSK----LTKD--FSALESQLQDTQ----ELLQEENRQK 1324
Query: 359 YQID--LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
+ L ++ ++ + L E ++ +++A+L++Q+ + + E
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 417 EISSAVTIDI--VKKENELK----EILTKECLKLSKLKIDIPRDLDQDLPAH---KKITI 467
E+ + D+ + + +E K + L K +L + D+ DLD + +K
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
FD L+ + + Y E+++ E A+ + E K
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAE---AREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 528 LHEELTKLYKSKVDENNANLNLIK---ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
E+ L SK D + L K L ++++ +K + + E+++ + +D KL L
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT--EDAKL-RL 1558
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQ----ASELERSCQVIKQNGFELDKMKADILMX 640
+ +K + D + EK+ Q E+E + ++ + + M
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD--CSRLEI--NIKTHEKTAEIQ 696
DEA L + A + C + D SR EI K +EK +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK 756
+++LQ+++ ++ + + + +EL ++ A+++ + QL +
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK--- 813
+ +G + ++ +N++L +
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1798
Query: 814 --LDDSPKRSISVISDSEVSQL--------KERLLSCQQEL---DDLKERYKELDDECET 860
+ K SI+ + +++++QL KER +C+Q LK+ ++DDE
Sbjct: 1799 GTVKSKYKASITAL-EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+Y + D+ RLK+ K LE+ + +++ ++R+ + A
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 56.0 bits (129), Expect = 7e-07
Identities = 50/234 (21%), Positives = 111/234 (47%), Gaps = 15/234 (6%)
Query: 828 SEVSQLKERLLSCQQ---ELDDLKERY----KELDDECETCAEYLQERDEQCARLKKEKL 880
+E QL+E+L + + E ++L+ R +EL++ C ++E +E+C L+ EK
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
++Q + L+EQ+ ++ ++ + V T+ L + + ++ K K+L+
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLE--KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 941 K-TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK--- 996
+ I E + + + K K+ + E + + E + ELE+ +++ +
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 997 -EL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+L D+ E A+ + + + K+ +E + AL V++ + QK K+I L +
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Score = 50.0 bits (114), Expect = 5e-05
Identities = 57/245 (23%), Positives = 106/245 (43%), Gaps = 16/245 (6%)
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
P L S + + + E+ +++E+ L+ + L +++ +L E E LQ E
Sbjct: 836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 872 CA-------RLKKEKLSLEQQVSNLKEQIRTQQP--VERQAKFADVAVNTDEDWANLHSV 922
CA RL +K LE+ +L+ ++ ++ QA+ + N E L
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R E + +K +EE + +D + K +K +E + EF E E
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAEFTTNLTEEE 1012
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEK 1041
+ L +LK +++ + + E E L++ E+Q + L++ + LE LS+Q L+
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 1042 QIESL 1046
QI L
Sbjct: 1070 QIAEL 1074
Score = 50.0 bits (114), Expect = 5e-05
Identities = 116/685 (16%), Positives = 279/685 (40%), Gaps = 58/685 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ-TRDLLMSQIKSLEMENLT 121
L + ++ ++L+ ++G L + S L + L + Q T++LL + + + L+
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR----QKLS 1326
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNEC 177
++K + D + +++ E +E L I + ++ K+++D L+ E
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTS 236
+ DLE L E K+ + + K + + + L + D+ + + +
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH---QRQSACNLEKKQ 1443
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE----NNEFE 292
+++++ + + A + ++ E K L + E+ E N +F
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 293 TKAVKVMS---EIKRNLNSL--SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV 347
T+ +MS ++ ++++ L S++ + + ++ K ++ +D L A DA+
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR------ 1557
Query: 348 FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI 407
E+ + + +++ DL E+ + + L E+++ E S +
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE- 1616
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLK-LSKLKIDIPRDLDQDLPAHKKIT 466
+ ++ H S+ D K+ + K+C++ L + L Q KK+
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 467 ILFDALIT-QYELS---RTDYEIEKEKLRL------ETGTAKAVXXXXXXXXXXXXXXFD 516
+ +I Q EL+ R + ++E+ L +G +
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE 1736
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK-NEEKMLSLS 575
LEE + +++ L K ++D+ N +LNL + +++ + + + + N+E + L
Sbjct: 1737 ELEEEQGNTELINDRLKKA-NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 576 EKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E + + ++ ++I L+ + L+ D T+E++ ++ R+ +K
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT-----------EKKL 1844
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS----RLEINIKTHE 690
D+L+ D+A + L+Q E+ EE+ + + +L+ ++
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFI 715
+TA+ NR + L+ +++ D F+
Sbjct: 1905 ETADAMNREVSSLKNKLRRGDLPFV 1929
Score = 49.2 bits (112), Expect = 8e-05
Identities = 76/387 (19%), Positives = 169/387 (43%), Gaps = 35/387 (9%)
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L+++ + E A+ + + +R +KQ+ +++L E ET ++L + L+ A +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVR-EKQLAAENRL-TEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ E +LT +K +E +LE+ + E+
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERC--------------QHLQAEKKKM 941
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
++L E + ++S ++ + V +++++ +L+E + + + L + K L+D
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ----QPVER-QAKFADVAVNTD 913
L E +E+ L K K E +++L+E++R + Q +E+ + K + +
Sbjct: 1002 AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+ A L + + + +M + E+ + + +EE +K + +++ + + + +
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 973 EFEAKRKELEDCKAEL-EELKQRYKELDEECETCA---EYLKQREEQCKRLK-----EAK 1023
A R + E K +L EEL+ EL++ ++ A E +RE++ LK EAK
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 1024 I-ALEIVDKLSNQKVALEKQIESLSNT 1049
+I + A+E+ E L T
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQT 1208
Score = 39.5 bits (88), Expect = 0.065
Identities = 37/180 (20%), Positives = 78/180 (43%), Gaps = 6/180 (3%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N +T+M+ + + + +
Sbjct: 827 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVD 1030
+ + + AE EEL+ R +EL+E C +++ EE+C+ L+ E K + +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 1031 KLSNQKVALEKQIESLSNTPV-SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+L Q E + L V + + + I+ Q + KE + L+ A+ T
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
>X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein.
Length = 2185
Score = 87.8 bits (208), Expect = 2e-16
Identities = 205/1051 (19%), Positives = 443/1051 (42%), Gaps = 102/1051 (9%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLM---SQIKSLEMENL 120
+E ++ + LEK E I ++K E LE Q + +L ++++ L+ E
Sbjct: 505 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE-LELQKKAILTESENKLRDLQQEAE 563
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT- 179
T I L SL+ KS + N+ Q + D +L E + + V+ K E L
Sbjct: 564 TYRTRILELESSLE-KSLQENKNQSK-DLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
Query: 180 -QKCIDLEKL-VNESENKIGPKNICAQCKL-KENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q + EKL V + + + + + +C+ KE L++ I + + ++N +
Sbjct: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK-LD 680
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN------- 289
+ ++ +L SEL + +L E+ + +K+ + + + +DE+ +
Sbjct: 681 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Query: 290 -EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
E E + +K +N L E L+ K K+H + ++L A + G L
Sbjct: 741 KEHEVSIQRTEKALKDQINQL-ELLLKERDKHLKEH-QAHVENLEADIKRSEG--ELQQA 796
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNI 407
+D + YQ E + Y + L + +L++ L +++ +K++ C
Sbjct: 797 SAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L K ++ ++ + +K+N E K ++ + K++ D +++ K+I +
Sbjct: 856 LDAHKIQVQDLMQQL-----EKQNSEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILV 907
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
+ +I Q E +K+++ + T A F E+ +VK
Sbjct: 908 EKENMILQMR------EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE----KMLSLSEKDNK-LT 582
+E+ + K K+ + A L +E++ + +++ E+ KML +++ ++ ++
Sbjct: 962 KAKEMQETLKKKLLDQEAKLK------KELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
Query: 583 ELVSTIN-GLKEENNSL-----KSLNDVIT---REKETQASELERSCQV-IKQNGFELDK 632
+ VS + KE+ SL + LNDVI+ ++ QA EL+ ++ +++ E+ +
Sbjct: 1016 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAE 1075
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL---EINIKTH 689
+K IL+ +E L+EQ ++K+ + L E +K H
Sbjct: 1076 LKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAH 1135
Query: 690 EKTAEIQ-NRMIMR---LQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAA 738
+ E+ N+ + LQ+Q+ E L E + K++ELT+K +++LK ++ +
Sbjct: 1136 LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKS 1195
Query: 739 VKDLESS----REAVNQLTTQKD--------LVEGRIAELESDIRTEQTATVXXXXXXXX 786
K LE ++ +L Q D L+E + EL +I + +T +
Sbjct: 1196 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL-INISSSKTNAILSRISHCQ 1254
Query: 787 XXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE-RLLSCQQELD 845
T + ++ +IS + + KE ++ S + +++
Sbjct: 1255 HRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE 1314
Query: 846 DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ----PVER 901
L + L E + E++ +LKKE V+ +KE+++ ++ + +
Sbjct: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSK 1374
Query: 902 QAKFADVAVNTDEDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDL-KNTVTK 959
Q +V + + + + R YD E+ L+ +++L +K L K ++
Sbjct: 1375 QLTDLNVQLQNSISLSEKEAAISSLRKQYD---EEKCELLDQVQDLSFKVDTLSKEKISA 1431
Query: 960 MQKA---MEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQREEQ 1015
+++ K+++ K+ +++ + ++ EL+ +L+ + KE E+ E ++ ++Q
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 1016 CKRLKEAKIALE-IVDKLSNQKVALEKQIES 1045
KR K +E K+ ++ LE +++S
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Score = 76.2 bits (179), Expect = 6e-13
Identities = 208/1084 (19%), Positives = 430/1084 (39%), Gaps = 80/1084 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-----LETQTRDLLMSQIKSL 115
Q + EI + +KLS + I E K++N ++ + +++ + K L
Sbjct: 915 QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 974
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKIN-ELQEENDTLSNLIMENVTESDNLNKE-VDDLKK 173
+ KE++N L K K+ N ++ E S I + V+ + KE ++ L +
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 174 NNECLTQKCIDL-EKLVNESENKIGPKNICAQCKLKENLIQSLH---IGYDNTLSKLNRS 229
+ I + EK +N+ ++ + Q + KE + L + + ++N+
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEI-QLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 230 IS--DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE 287
I+ + + LQ +L L +D T +K HLE + +DL++ L E
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE----KLEVDLNKSLKE 1149
Query: 288 NNEFETKAVKVM---SEIKRNLNSLSEQL-INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
N + + V++ E KR ++ L+ +L +E +S + L EF
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGD-LNECTSELKSVNEKLASLNSQLIEKE 402
S ++ I +D K + L+ + + N S + + + L+ K
Sbjct: 1210 SEEL-AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
+ L Q ++ E + + I + ++L+E KE ++ +K DI L + A
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEE---KEN-QIKSMKADI-ESLVTEKEAL 1323
Query: 463 KKITILFDALITQYELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
+K ++ E T + E E + T + + D +
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 522 HNEVKSLHEE--LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD- 578
N + +E ++ L K +E L+ ++ LS ++D L ++EK+ +L + D
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL------SKEKISALEQVDD 1437
Query: 579 --NKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
NK +E + N++K L + K +A E + ++K+ + +K +
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQ-IQLELKSKEAYEKDEQINLLKEELDQQNK-RF 1495
Query: 636 DILMXXXXXXXXXXXXXXXX--DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
D L E KS + + L++ +KT + L +K + +
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 694 EIQNR-MIMRLQ--KQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+I+++ ++ +LQ +++ +E D E E K+ L N+ ++K + + K+LE +V
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV 1615
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF--GDENRD 807
+ +E R+ E ES + + + G E+
Sbjct: 1616 KSKEEELKALEDRL-ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674
Query: 808 LGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
N KL + +R + ++ + V + L + ++ ++ + + + C +
Sbjct: 1675 SELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 866 -QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS--V 922
+E+ R EK L Q+V KE+ + E + ++ + + + A H
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH-FEMRCQYQERLIKLEHAEAKQHEDQS 1792
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYK---------KQDLKNTVTKMQKAMEKYTKKDKE 973
++ + + E EKNK+ + + K KQ+L+N +QK +++ +
Sbjct: 1793 MIGHLQEELE-EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
E K KEL+ C L K+ ++ EE + E L+ ++ R K ++ E ++ S
Sbjct: 1852 LEQKIKELDSC---LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ----QITDVMKENQKLKKMNAKLIT 1089
+ Q + LSN ++ + A + Q +I + K+ + L+K + + +
Sbjct: 1909 KSHLV---QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1965
Query: 1090 ICKK 1093
I KK
Sbjct: 1966 ILKK 1969
Score = 58.0 bits (134), Expect = 2e-07
Identities = 146/657 (22%), Positives = 267/657 (40%), Gaps = 63/657 (9%)
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIH----EISSAVTID--IVKKENELKE 435
S++ S E L NS + KE LR + + + S VT + +++ +L+
Sbjct: 118 SDMDSEAEDLVG-NSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE--LSRTDYEIEKEKLRLE 493
IL++ K + ++ +L D A K + FDA + + + +S ++ K RL
Sbjct: 177 ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT--KLYKSKVDENNANLNLIK 551
G F E ++ + + E+ T K ++ NL+K
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296
Query: 552 ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKET 611
E I + K E+ L SEK+ L E L E L+ + D+ EK
Sbjct: 297 RCKETIQSHK------EQCTLLTSEKE-ALQEQ------LDERLQELEKIKDLHMAEKTK 343
Query: 612 QASELERSCQVIKQNGFELDKMKADIL-MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
++L + +I+Q + + A+ K + Q L+E
Sbjct: 344 LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403
Query: 671 QCEEKTRDC-SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
Q E+ R LE + T +KT E + ++ + +QI+ +K E+ L + ++
Sbjct: 404 QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSR-- 461
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
+K++ +K +SS E + +L QK L E +A E ++ T++ T
Sbjct: 462 -VKQEVVDVMK--KSSEEQIAKL--QK-LHEKELARKEQEL-TKKLQTREREFQEQMKVA 514
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
+ ++ E+ L++ + +++++SE +L QQE + +
Sbjct: 515 LEKSQSEYLKI--SQEKEQQESLALEELELQKKAILTESE-----NKLRDLQQEAETYRT 567
Query: 850 RYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA 909
R EL+ E + LQE Q L + LE + + ++I T + + + +
Sbjct: 568 RILELESSLE---KSLQENKNQSKDLA---VHLEAEKNKHNKEI-TVMVEKHKTELESLK 620
Query: 910 VNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
D W V+ + Y E+EK + K +E K+ LK+ Q +E+ +
Sbjct: 621 HQQDALWTEKLQVL--KQQYQTEMEKLRE--KCEQE---KETLLKDKEIIFQAHIEEMNE 673
Query: 970 KDKE-FEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
K E + K+ ELE +EL E LK R+K L+EE LK + ++ K+ EAK+
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHK-LEEELSV----LKDQTDKMKQELEAKM 725
Score = 53.6 bits (123), Expect = 4e-06
Identities = 150/825 (18%), Positives = 325/825 (39%), Gaps = 56/825 (6%)
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
++ + K+++ ++E++ L +Q ++ D KD ++VL + +
Sbjct: 179 SQSQDKSLRRIAELREELQM--DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS-VNEKLASLNSQLIEKENACNI 407
M+ + K L+ E +TK + ++ ++ + K Q ++++ N+
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQE--NL 294
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L+ KE I T+ +KE L+E L + +L K+K DL K IT
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKE-ALQEQLDERLQELEKIK-----DLHM-AEKTKLITQ 347
Query: 468 LFDA--LITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
L DA LI Q E + E ++ ET K + + E+
Sbjct: 348 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
++ EEL K + A L + E+I ++ +EE+ +SL ++ +++ +
Sbjct: 408 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE---KTSEEERISLQQELSRVKQ 464
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
V + K + L + +E + EL + Q ++ F+ ++MK +
Sbjct: 465 EVVDVMK-KSSEEQIAKLQKLHEKELARKEQELTKKLQT-REREFQ-EQMKVALEKSQSE 521
Query: 644 XXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
A LE Q A+ + E K RD + +T + E+++ +
Sbjct: 522 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT--RILELESSLEKS 579
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV---------NQLT 753
LQ+ + L + E + N+ + + + ++ L+ ++A+ Q
Sbjct: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
T+ + + + E E + + + + +L E K
Sbjct: 640 TEMEKLREK-CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
+ +SV+ D + ++K+ L + ++D+ K +++ D E +R E+
Sbjct: 699 ARHKLEEELSVLKD-QTDKMKQEL---EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL 754
Query: 874 R--LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ + + +L L+++ +LKE Q VE AD+ + E + V + A
Sbjct: 755 KDQINQLELLLKERDKHLKEH---QAHVENLE--ADIKRSEGELQQASAKLDVFQSYQSA 809
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
E+ K + + +L+ K DL+ + TK+ E EA++K++ C EL+
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETERILL-------TKQVAEVEAQKKDV--C-TELDAH 859
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPV 1051
K + ++L ++ E ++Q+ + ++ E+K+ ++ +++ +EK+ L
Sbjct: 860 KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREG 919
Query: 1052 SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+ + T + I + +E + K K + K++ K
Sbjct: 920 QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Score = 49.6 bits (113), Expect = 6e-05
Identities = 158/775 (20%), Positives = 312/775 (40%), Gaps = 70/775 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINL--KLEKLSGELFD 83
QL S+N N + +K + ++S ++ + N I+L K +S
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK--EIKNLTDSLKTKSKK-I 140
E+K L + Q+L + T L +I +LE + +K E K S T+ + +
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDT--LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 141 NELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-- 198
ELQ + + S E + + L +E+D K +CL + D + + + E+ +
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKE 258
K+ A+ E+ I I ++ L+++ ++ + + LQ + G E
Sbjct: 1521 KSQTARIMELEDHITQKTIEIES-LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 259 LCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ E I LE +M +L+ K E E + V S+ + L +L ++L +ES
Sbjct: 1580 VKEAEEKILT-LENQVYSMKAELETK---KKELEHVNLSVKSK-EEELKALEDRL-ESES 1633
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLN 378
+ R + +A + + L E + + L E+ K + + +++
Sbjct: 1634 AAKLAELKRKAEQKIAAIKKQL----LSQMEEKEEQYKKGTESHLSELNTKLQEREREVH 1689
Query: 379 ECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILT 438
+LKSV +S + LI +A N+ ++ + V +K + L+ LT
Sbjct: 1690 ILEEKLKSVE---SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
Query: 439 KECLKLSKLKID----IPRDLDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKL 490
++ L ++ + + + +++ L A Q+E + E+E++
Sbjct: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV-KSLHE-ELT-KLYKSKVDENNANL 547
+ A+ V LE ++V K+L E ELT ++ + K+ E ++ L
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAK---QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
Query: 548 NLIKILSEEIDALKIA-IAKNEEKMLSLSEKD--NKLTELVSTINGLKEENNSLKSLNDV 604
+ +E+ +++ + EK+ +L + D NK TEL+ EE + +
Sbjct: 1864 ----VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT---EEKSKSHLVQPK 1916
Query: 605 ITREKETQASELE---RSCQVIKQN-GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ E Q ++LE + KQ G E+ +++ D+ M D+ +
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1976
Query: 661 L----------LEQNLALKEQCEEKTRDCSR----LEINIK-THEKTAEIQNRMIMRLQK 705
L+ N LK+ E ++ LE+ IK T K E++ ++ Q+
Sbjct: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE 2036
Query: 706 QIQEDDKLFIEKETKLNELTNKYE----ALKRDYDAAVKDLESSREAVNQLTTQK 756
+ + K EK+ L +YE A + + A V+DL++ E + + QK
Sbjct: 2037 ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 2091
Score = 41.9 bits (94), Expect = 0.012
Identities = 121/616 (19%), Positives = 257/616 (41%), Gaps = 50/616 (8%)
Query: 24 RNQLDGAKSKNDNIIETQSNPI-KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
+++++ +S + +++Q+ I +L+D IT +SL E N + + EL
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDH--ITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 83 DIKEQKSALEGKYQNLILETQTRDL-LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKIN 141
+ L + N + E + + L L +Q+ S++ E TK KE++++ S+K+K +++
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
L++ ++ S + + +++ +KK + L+Q E+ +E+ + N
Sbjct: 1624 ALEDRLESESAAKLAELKR--KAEQKIAAIKK--QLLSQMEEKEEQYKKGTESHLSELN- 1678
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGREDCKELC 260
KL+E + +HI + L + S S++ R K + + +A + C +
Sbjct: 1679 ---TKLQER-EREVHI-LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ-- 1731
Query: 261 EDFTSIKNHLELHEPNMT--MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ + + + + N+T L +++G+ E ET V S + E+LI E
Sbjct: 1732 ---KTYEEKISVLQRNLTEKEKLLQRVGQEKE-ET----VSSHFEMRC-QYQERLIKLEH 1782
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII---NKYQIDLDEILEK-YTKVQ 374
++K H D+ S++ L E + I+ ++ K I + LE + VQ
Sbjct: 1783 AEAKQHEDQ---SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 375 GDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI-HEISSAVTIDIVKKENEL 433
L E + + +K+ L+S L+ ++ + R++ E + + + + N+
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQK---EVHRVEMEELTSKYEKLQALQQMDGRNKP 1896
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI-LFDALITQYELSRTDYEIEKEKLRL 492
E+L + + SK + P+ L H + L A + +L + ++K+ L
Sbjct: 1897 TELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 493 ETGTAKAVXXXXXXXXXXXXXXF----DTLEEAHNE-VKSLHEELTKLYKSKVDENNANL 547
+ + + LE HN +K L E K E +
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI 2016
Query: 548 NLIKILSEEIDALKIAIAKNEEKML--SLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
++E++A + + E L ++EKD+ +L T +E ++ +
Sbjct: 2017 KETINKAQEVEAELLESHQEETNQLLKKIAEKDD---DLKRTAKRYEEILDAREEEMTAK 2073
Query: 606 TREKETQASELERSCQ 621
R+ +TQ EL++ Q
Sbjct: 2074 VRDLQTQLEELQKKYQ 2089
>U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein.
Length = 2230
Score = 87.8 bits (208), Expect = 2e-16
Identities = 205/1051 (19%), Positives = 443/1051 (42%), Gaps = 102/1051 (9%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLM---SQIKSLEMENL 120
+E ++ + LEK E I ++K E LE Q + +L ++++ L+ E
Sbjct: 505 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE-LELQKKAILTESENKLRDLQQEAE 563
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT- 179
T I L SL+ KS + N+ Q + D +L E + + V+ K E L
Sbjct: 564 TYRTRILELESSLE-KSLQENKNQSK-DLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
Query: 180 -QKCIDLEKL-VNESENKIGPKNICAQCKL-KENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q + EKL V + + + + + +C+ KE L++ I + + ++N +
Sbjct: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK-LD 680
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN------- 289
+ ++ +L SEL + +L E+ + +K+ + + + +DE+ +
Sbjct: 681 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Query: 290 -EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
E E + +K +N L E L+ K K+H + ++L A + G L
Sbjct: 741 KEHEVSIQRTEKALKDQINQL-ELLLKERDKHLKEH-QAHVENLEADIKRSEG--ELQQA 796
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNI 407
+D + YQ E + Y + L + +L++ L +++ +K++ C
Sbjct: 797 SAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L K ++ ++ + +K+N E K ++ + K++ D +++ K+I +
Sbjct: 856 LDAHKIQVQDLMQQL-----EKQNSEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILV 907
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
+ +I Q E +K+++ + T A F E+ +VK
Sbjct: 908 EKENMILQMR------EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE----KMLSLSEKDNK-LT 582
+E+ + K K+ + A L +E++ + +++ E+ KML +++ ++ ++
Sbjct: 962 KAKEMQETLKKKLLDQEAKLK------KELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
Query: 583 ELVSTIN-GLKEENNSL-----KSLNDVIT---REKETQASELERSCQV-IKQNGFELDK 632
+ VS + KE+ SL + LNDVI+ ++ QA EL+ ++ +++ E+ +
Sbjct: 1016 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAE 1075
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL---EINIKTH 689
+K IL+ +E L+EQ ++K+ + L E +K H
Sbjct: 1076 LKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAH 1135
Query: 690 EKTAEIQ-NRMIMR---LQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAA 738
+ E+ N+ + LQ+Q+ E L E + K++ELT+K +++LK ++ +
Sbjct: 1136 LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKS 1195
Query: 739 VKDLESS----REAVNQLTTQKD--------LVEGRIAELESDIRTEQTATVXXXXXXXX 786
K LE ++ +L Q D L+E + EL +I + +T +
Sbjct: 1196 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL-INISSSKTNAILSRISHCQ 1254
Query: 787 XXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE-RLLSCQQELD 845
T + ++ +IS + + KE ++ S + +++
Sbjct: 1255 HRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE 1314
Query: 846 DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ----PVER 901
L + L E + E++ +LKKE V+ +KE+++ ++ + +
Sbjct: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSK 1374
Query: 902 QAKFADVAVNTDEDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDL-KNTVTK 959
Q +V + + + + R YD E+ L+ +++L +K L K ++
Sbjct: 1375 QLTDLNVQLQNSISLSEKEAAISSLRKQYD---EEKCELLDQVQDLSFKVDTLSKEKISA 1431
Query: 960 MQKA---MEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQREEQ 1015
+++ K+++ K+ +++ + ++ EL+ +L+ + KE E+ E ++ ++Q
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 1016 CKRLKEAKIALE-IVDKLSNQKVALEKQIES 1045
KR K +E K+ ++ LE +++S
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Score = 76.2 bits (179), Expect = 6e-13
Identities = 208/1084 (19%), Positives = 430/1084 (39%), Gaps = 80/1084 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-----LETQTRDLLMSQIKSL 115
Q + EI + +KLS + I E K++N ++ + +++ + K L
Sbjct: 915 QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 974
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKIN-ELQEENDTLSNLIMENVTESDNLNKE-VDDLKK 173
+ KE++N L K K+ N ++ E S I + V+ + KE ++ L +
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 174 NNECLTQKCIDL-EKLVNESENKIGPKNICAQCKLKENLIQSLH---IGYDNTLSKLNRS 229
+ I + EK +N+ ++ + Q + KE + L + + ++N+
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEI-QLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 230 IS--DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE 287
I+ + + LQ +L L +D T +K HLE + +DL++ L E
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE----KLEVDLNKSLKE 1149
Query: 288 NNEFETKAVKVM---SEIKRNLNSLSEQL-INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
N + + V++ E KR ++ L+ +L +E +S + L EF
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGD-LNECTSELKSVNEKLASLNSQLIEKE 402
S ++ I +D K + L+ + + N S + + + L+ K
Sbjct: 1210 SEEL-AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
+ L Q ++ E + + I + ++L+E KE ++ +K DI L + A
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEE---KEN-QIKSMKADI-ESLVTEKEAL 1323
Query: 463 KKITILFDALITQYELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
+K ++ E T + E E + T + + D +
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 522 HNEVKSLHEE--LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD- 578
N + +E ++ L K +E L+ ++ LS ++D L ++EK+ +L + D
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL------SKEKISALEQVDD 1437
Query: 579 --NKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
NK +E + N++K L + K +A E + ++K+ + +K +
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQ-IQLELKSKEAYEKDEQINLLKEELDQQNK-RF 1495
Query: 636 DILMXXXXXXXXXXXXXXXX--DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
D L E KS + + L++ +KT + L +K + +
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 694 EIQNR-MIMRLQ--KQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+I+++ ++ +LQ +++ +E D E E K+ L N+ ++K + + K+LE +V
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV 1615
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF--GDENRD 807
+ +E R+ E ES + + + G E+
Sbjct: 1616 KSKEEELKALEDRL-ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674
Query: 808 LGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
N KL + +R + ++ + V + L + ++ ++ + + + C +
Sbjct: 1675 SELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 866 -QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS--V 922
+E+ R EK L Q+V KE+ + E + ++ + + + A H
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH-FEMRCQYQERLIKLEHAEAKQHEDQS 1792
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYK---------KQDLKNTVTKMQKAMEKYTKKDKE 973
++ + + E EKNK+ + + K KQ+L+N +QK +++ +
Sbjct: 1793 MIGHLQEELE-EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
E K KEL+ C L K+ ++ EE + E L+ ++ R K ++ E ++ S
Sbjct: 1852 LEQKIKELDSC---LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ----QITDVMKENQKLKKMNAKLIT 1089
+ Q + LSN ++ + A + Q +I + K+ + L+K + + +
Sbjct: 1909 KSHLV---QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1965
Query: 1090 ICKK 1093
I KK
Sbjct: 1966 ILKK 1969
Score = 58.0 bits (134), Expect = 2e-07
Identities = 146/657 (22%), Positives = 267/657 (40%), Gaps = 63/657 (9%)
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIH----EISSAVTID--IVKKENELKE 435
S++ S E L NS + KE LR + + + S VT + +++ +L+
Sbjct: 118 SDMDSEAEDLVG-NSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE--LSRTDYEIEKEKLRLE 493
IL++ K + ++ +L D A K + FDA + + + +S ++ K RL
Sbjct: 177 ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT--KLYKSKVDENNANLNLIK 551
G F E ++ + + E+ T K ++ NL+K
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296
Query: 552 ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKET 611
E I + K E+ L SEK+ L E L E L+ + D+ EK
Sbjct: 297 RCKETIQSHK------EQCTLLTSEKE-ALQEQ------LDERLQELEKIKDLHMAEKTK 343
Query: 612 QASELERSCQVIKQNGFELDKMKADIL-MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
++L + +I+Q + + A+ K + Q L+E
Sbjct: 344 LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403
Query: 671 QCEEKTRDC-SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
Q E+ R LE + T +KT E + ++ + +QI+ +K E+ L + ++
Sbjct: 404 QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSR-- 461
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
+K++ +K +SS E + +L QK L E +A E ++ T++ T
Sbjct: 462 -VKQEVVDVMK--KSSEEQIAKL--QK-LHEKELARKEQEL-TKKLQTREREFQEQMKVA 514
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
+ ++ E+ L++ + +++++SE +L QQE + +
Sbjct: 515 LEKSQSEYLKI--SQEKEQQESLALEELELQKKAILTESE-----NKLRDLQQEAETYRT 567
Query: 850 RYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA 909
R EL+ E + LQE Q L + LE + + ++I T + + + +
Sbjct: 568 RILELESSLE---KSLQENKNQSKDLA---VHLEAEKNKHNKEI-TVMVEKHKTELESLK 620
Query: 910 VNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
D W V+ + Y E+EK + K +E K+ LK+ Q +E+ +
Sbjct: 621 HQQDALWTEKLQVL--KQQYQTEMEKLRE--KCEQE---KETLLKDKEIIFQAHIEEMNE 673
Query: 970 KDKE-FEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
K E + K+ ELE +EL E LK R+K L+EE LK + ++ K+ EAK+
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHK-LEEELSV----LKDQTDKMKQELEAKM 725
Score = 53.6 bits (123), Expect = 4e-06
Identities = 150/825 (18%), Positives = 325/825 (39%), Gaps = 56/825 (6%)
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
++ + K+++ ++E++ L +Q ++ D KD ++VL + +
Sbjct: 179 SQSQDKSLRRIAELREELQM--DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS-VNEKLASLNSQLIEKENACNI 407
M+ + K L+ E +TK + ++ ++ + K Q ++++ N+
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQE--NL 294
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L+ KE I T+ +KE L+E L + +L K+K DL K IT
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKE-ALQEQLDERLQELEKIK-----DLHM-AEKTKLITQ 347
Query: 468 LFDA--LITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
L DA LI Q E + E ++ ET K + + E+
Sbjct: 348 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
++ EEL K + A L + E+I ++ +EE+ +SL ++ +++ +
Sbjct: 408 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE---KTSEEERISLQQELSRVKQ 464
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
V + K + L + +E + EL + Q ++ F+ ++MK +
Sbjct: 465 EVVDVMK-KSSEEQIAKLQKLHEKELARKEQELTKKLQT-REREFQ-EQMKVALEKSQSE 521
Query: 644 XXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
A LE Q A+ + E K RD + +T + E+++ +
Sbjct: 522 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT--RILELESSLEKS 579
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV---------NQLT 753
LQ+ + L + E + N+ + + + ++ L+ ++A+ Q
Sbjct: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
T+ + + + E E + + + + +L E K
Sbjct: 640 TEMEKLREK-CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
+ +SV+ D + ++K+ L + ++D+ K +++ D E +R E+
Sbjct: 699 ARHKLEEELSVLKD-QTDKMKQEL---EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL 754
Query: 874 R--LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ + + +L L+++ +LKE Q VE AD+ + E + V + A
Sbjct: 755 KDQINQLELLLKERDKHLKEH---QAHVENLE--ADIKRSEGELQQASAKLDVFQSYQSA 809
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
E+ K + + +L+ K DL+ + TK+ E EA++K++ C EL+
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETERILL-------TKQVAEVEAQKKDV--C-TELDAH 859
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPV 1051
K + ++L ++ E ++Q+ + ++ E+K+ ++ +++ +EK+ L
Sbjct: 860 KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREG 919
Query: 1052 SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+ + T + I + +E + K K + K++ K
Sbjct: 920 QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Score = 49.6 bits (113), Expect = 6e-05
Identities = 158/775 (20%), Positives = 312/775 (40%), Gaps = 70/775 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINL--KLEKLSGELFD 83
QL S+N N + +K + ++S ++ + N I+L K +S
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK--EIKNLTDSLKTKSKK-I 140
E+K L + Q+L + T L +I +LE + +K E K S T+ + +
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDT--LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 141 NELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-- 198
ELQ + + S E + + L +E+D K +CL + D + + + E+ +
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKE 258
K+ A+ E+ I I ++ L+++ ++ + + LQ + G E
Sbjct: 1521 KSQTARIMELEDHITQKTIEIES-LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 259 LCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ E I LE +M +L+ K E E + V S+ + L +L ++L +ES
Sbjct: 1580 VKEAEEKILT-LENQVYSMKAELETK---KKELEHVNLSVKSK-EEELKALEDRL-ESES 1633
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLN 378
+ R + +A + + L E + + L E+ K + + +++
Sbjct: 1634 AAKLAELKRKAEQKIAAIKKQL----LSQMEEKEEQYKKGTESHLSELNTKLQEREREVH 1689
Query: 379 ECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILT 438
+LKSV +S + LI +A N+ ++ + V +K + L+ LT
Sbjct: 1690 ILEEKLKSVE---SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
Query: 439 KECLKLSKLKID----IPRDLDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKL 490
++ L ++ + + + +++ L A Q+E + E+E++
Sbjct: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV-KSLHE-ELT-KLYKSKVDENNANL 547
+ A+ V LE ++V K+L E ELT ++ + K+ E ++ L
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAK---QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
Query: 548 NLIKILSEEIDALKIA-IAKNEEKMLSLSEKD--NKLTELVSTINGLKEENNSLKSLNDV 604
+ +E+ +++ + EK+ +L + D NK TEL+ EE + +
Sbjct: 1864 ----VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT---EEKSKSHLVQPK 1916
Query: 605 ITREKETQASELE---RSCQVIKQN-GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ E Q ++LE + KQ G E+ +++ D+ M D+ +
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1976
Query: 661 L----------LEQNLALKEQCEEKTRDCSR----LEINIK-THEKTAEIQNRMIMRLQK 705
L+ N LK+ E ++ LE+ IK T K E++ ++ Q+
Sbjct: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE 2036
Query: 706 QIQEDDKLFIEKETKLNELTNKYE----ALKRDYDAAVKDLESSREAVNQLTTQK 756
+ + K EK+ L +YE A + + A V+DL++ E + + QK
Sbjct: 2037 ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 2091
Score = 41.9 bits (94), Expect = 0.012
Identities = 121/616 (19%), Positives = 257/616 (41%), Gaps = 50/616 (8%)
Query: 24 RNQLDGAKSKNDNIIETQSNPI-KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
+++++ +S + +++Q+ I +L+D IT +SL E N + + EL
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDH--ITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 83 DIKEQKSALEGKYQNLILETQTRDL-LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKIN 141
+ L + N + E + + L L +Q+ S++ E TK KE++++ S+K+K +++
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
L++ ++ S + + +++ +KK + L+Q E+ +E+ + N
Sbjct: 1624 ALEDRLESESAAKLAELKR--KAEQKIAAIKK--QLLSQMEEKEEQYKKGTESHLSELN- 1678
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGREDCKELC 260
KL+E + +HI + L + S S++ R K + + +A + C +
Sbjct: 1679 ---TKLQER-EREVHI-LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ-- 1731
Query: 261 EDFTSIKNHLELHEPNMT--MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ + + + + N+T L +++G+ E ET V S + E+LI E
Sbjct: 1732 ---KTYEEKISVLQRNLTEKEKLLQRVGQEKE-ET----VSSHFEMRC-QYQERLIKLEH 1782
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII---NKYQIDLDEILEK-YTKVQ 374
++K H D+ S++ L E + I+ ++ K I + LE + VQ
Sbjct: 1783 AEAKQHEDQ---SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 375 GDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI-HEISSAVTIDIVKKENEL 433
L E + + +K+ L+S L+ ++ + R++ E + + + + N+
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQK---EVHRVEMEELTSKYEKLQALQQMDGRNKP 1896
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI-LFDALITQYELSRTDYEIEKEKLRL 492
E+L + + SK + P+ L H + L A + +L + ++K+ L
Sbjct: 1897 TELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 493 ETGTAKAVXXXXXXXXXXXXXXF----DTLEEAHNE-VKSLHEELTKLYKSKVDENNANL 547
+ + + LE HN +K L E K E +
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI 2016
Query: 548 NLIKILSEEIDALKIAIAKNEEKML--SLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
++E++A + + E L ++EKD+ +L T +E ++ +
Sbjct: 2017 KETINKAQEVEAELLESHQEETNQLLKKIAEKDD---DLKRTAKRYEEILDAREEEMTAK 2073
Query: 606 TREKETQASELERSCQ 621
R+ +TQ EL++ Q
Sbjct: 2074 VRDLQTQLEELQKKYQ 2089
>U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protein
protein.
Length = 3210
Score = 87.8 bits (208), Expect = 2e-16
Identities = 208/1024 (20%), Positives = 439/1024 (42%), Gaps = 112/1024 (10%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
+ EL I+ +K+++E ++ L LE +++ ++ LE +N K K I L + L
Sbjct: 1996 VENELSRIRSEKASIE--HEALYLEADL-EVVQTEKLCLEKDNENKQKVIVCLEEELSVV 2052
Query: 137 SKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
+ + N+L+ E DT+S + T D L++++ + + E +C+ + +E ++
Sbjct: 2053 TSERNQLRGELDTMS----KKTTALDQLSEKMKEKTQELESHQSECL---HCIQVAEAEV 2105
Query: 197 GPKNICAQCKLKENLIQSLHIGYDNT-LSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
K Q L ++ + L D T L + +S+ + + K C L++++ ++
Sbjct: 2106 KEKTELLQ-TLSSDVSELLK---DKTHLQEKLQSLEKDSQALSLTK-CELENQIAQLNKE 2160
Query: 256 CKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEF------------------ETK 294
+ L ++ S++ L + + N++ L+ L E EF E
Sbjct: 2161 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2220
Query: 295 AVKVMSEIKRNLN---SLSEQLINNESKKSK-DHIDR-----YKDSLLAVLDAEFGTTSL 345
V++ ++ K+ L+ L E+ N+S K K ++++R ++ L +LDAE +
Sbjct: 2221 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2280
Query: 346 DVFEILMDNI---INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + ++ + + +++DL + + + + E +L +++ L+S S L EKE
Sbjct: 2281 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2340
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEIL--TKECLKLSKLKIDIPRDLDQDL- 459
A IQ + + + + + +K+ NE L +E +K ++ +D P + + L
Sbjct: 2341 QA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2396
Query: 460 PAHKKITILFDA-----LITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXXXXX 509
+ +K+ +A L +L +++ + E L E A+
Sbjct: 2397 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE 2456
Query: 510 XXXXXFDTL----EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE-EI--DALKI 562
+TL E ++ L ++ + K D N + +SE EI + +
Sbjct: 2457 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFEN 2516
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL-ND-VITREKETQASELERSC 620
+ + E++ + + EK + E++ T LKE N + +L ND + KE S
Sbjct: 2517 ILQEKEQEKVQMKEKSSTAMEMLQT--QLKELNERVAALHNDQEACKAKEQNLSSQVECL 2574
Query: 621 QVIKQNGFE-LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ K + LD+ K + ++ + + E+ LK Q +++ +
Sbjct: 2575 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2634
Query: 680 SRLEINIKTH----EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
S+L H E+ E++N + + L+++IQ + L L + Y+ L+ +
Sbjct: 2635 SKLSQVEGEHQLWKEQNLELRN-LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2693
Query: 736 DAAVKDLESSREAVNQLTT-----QKDLVE--GRIAELESDIRTEQTATVXXXXXXXXXX 788
+ D S E VN++T Q+++ E + AEL+ ++ E+
Sbjct: 2694 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2753
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD--SEVSQLKERLLSCQQELDD 846
EN +L ++ LD K + E+++ + RL +++
Sbjct: 2754 KSSKDQLKELTL---ENSELKKS--LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2808
Query: 847 -LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
L + K+ + E +T E L + E+C L +KL ++ S+ KE++ ++ +
Sbjct: 2809 LLLDTNKQYEVEIQTYREKLTSK-EEC--LSSQKLEIDLLKSS-KEELNNS--LKATTQI 2862
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
+ T D NL V + + K K L+K+ ++L +K+ L+ ++++Q A E
Sbjct: 2863 LEELKKTKMD--NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2920
Query: 966 KY---TKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K T D + + E+++ K LEE K+ + LD+ C + ++ E+ K + E
Sbjct: 2921 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH--EKLEKAKEMLE 2978
Query: 1022 AKIA 1025
++A
Sbjct: 2979 TQVA 2982
Score = 77.8 bits (183), Expect = 2e-13
Identities = 215/1013 (21%), Positives = 386/1013 (38%), Gaps = 74/1013 (7%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ L L K +E++ D LK K+ + Q + D+L + + +N E +LK
Sbjct: 10 EGLPTRTLQKIQELEGQLDKLK---KEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLK 66
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ N+ L + C LEK + +++ K +Q +E + S + +L R S+
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKE--SQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
S + QS D C + FT+ + + + DL EK N E E
Sbjct: 125 LERSQQ-----AAQS-ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY--NKEVE 176
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDV----F 348
+ ++ +E+K + Q + + +D S + E + L
Sbjct: 177 ERK-RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT 235
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQG--DLNECTSELKSVNEKLASLNSQLIEKENACN 406
I D + + +L+ + T G D N S L L +Q E N N
Sbjct: 236 PIRRDFSASYFSGELEVTPSRSTLQIGKRDANSSFFGNSSSPHLLDQLKAQNQELRNKIN 295
Query: 407 ILRI-----QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
L + +KE +++ + + + E E++ KE + L+K + ++ R Q A
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQL-QLEKAKVELIEKEKV-LNKCRDELVRTTAQYDQA 353
Query: 462 HKKITILFDAL--ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
K T L L +T+ +LS E + LE K F TL+
Sbjct: 354 STKYTALEQKLKKLTE-DLSCQRQNAESARCSLEQ-KIKEKEKEFQEELSRQQRSFQTLD 411
Query: 520 EAHNEVKS-LHEEL--TKLYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLS 575
+ ++K+ L +EL K + + L +K L ++ K + + E+ +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K+N EL ++ +K+ENN LKS ++ RE +EL+ Q + Q+ ++MKA
Sbjct: 472 IKEN---ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA 528
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ SL + L L EK RDCS + +K E E
Sbjct: 529 ---KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS--QDLLKKREHHIEQ 583
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
N +L K +E L E K E YE LK + + + + Q+ ++
Sbjct: 584 LND---KLSKTEKESKALLSALELKKKE----YEELKEEKTLFSCWKSENEKLLTQMESE 636
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG---DENRDLGENP 812
K+ ++ +I LE+ ++T+Q + D E
Sbjct: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
Query: 813 KLDDSPKRSISVISDSE-VSQLKERLLSCQQ---ELDDLKERYKELDDEC---ETCAEYL 865
KL + + SD + +++ L Q +++DL+ + + L +E + C + L
Sbjct: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
Query: 866 QERDEQCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
E L K K SL + + + Q FA++ + + S
Sbjct: 757 HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI-IGEQGSMPSERSEC- 814
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
R+ D + + L ++ L + + K + +QK E+ + E E + E
Sbjct: 815 -RLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 985 -KAELEELKQRYKELDEEC----ETCAEYLKQREEQCKRLK--EAKIALE--IVDKLSNQ 1035
++ + E QR +L E+ AE L E + K L+ K+ E + +L
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS 933
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKL 1087
LE ++ L + S S I N ++I ++ +EN LK++NA L
Sbjct: 934 NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
Score = 76.6 bits (180), Expect = 5e-13
Identities = 206/989 (20%), Positives = 416/989 (42%), Gaps = 99/989 (10%)
Query: 65 ESSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
E NE K + L EL + +++ L G+ + +T D L ++K E +
Sbjct: 2032 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 2091
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT-QKC 182
E + + + K+ EL + TLS+ + E + + +L +++ L+K+++ L+ KC
Sbjct: 2092 SECLHCIQVAEAEVKEKTELLQ---TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2148
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
E EN+I N + +KE+ + ++ KLN +S + + K
Sbjct: 2149 --------ELENQIAQLNKEKELLVKESESLQARLS-ESDYEKLN--VSKALEAALVEK- 2196
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEP---NMTMDLDEKLGENNEFETKAVKVM 299
L + +E+ +L ++ +E E ++ L E+ EN+ + K +
Sbjct: 2197 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2256
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
E++ ++ +++L+ +++ SK ++ K + E SL VFE+ + + ++
Sbjct: 2257 RELQ--MSEENQELVILDAENSKAEVETLKTQI------EEMARSLKVFELDLVTLRSEK 2308
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK-ENACNILRIQKERIHEI 418
+ +I EK ++ +L++ S KS+ E+ Q+ E+ + A +L+ Q + ++E
Sbjct: 2309 ENLTKQIQEKQGQLS-ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2367
Query: 419 SSAVTID--IVKK-ENELKEILTKECL---KLSKLKIDIPRDLDQDLPAHKKITIL---F 469
+A+ D I+K E L + +E + KL+ + D + L +++
Sbjct: 2368 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2427
Query: 470 DALITQYELSRTDYEIEK---EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
D L + E + EI + E LE +K LE ++
Sbjct: 2428 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2487
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
S E+LT + K E + L +I E I + + E++ + + EK + E++
Sbjct: 2488 SEKEDLTNELQ-KEQERISELEIINSSFENI------LQEKEQEKVQMKEKSSTAMEMLQ 2540
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
T LKE N + +L++ ++ +A E S QV EL+K A +L
Sbjct: 2541 T--QLKELNERVAALHN---DQEACKAKEQNLSSQV---ECLELEK--AQLLQGLDEAKN 2590
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+ L+++ K++ E+K + SRL+ I+ E+ ++ +L Q
Sbjct: 2591 NYIVLQSSVN---GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-------LVSKLS-Q 2639
Query: 707 IQEDDKLFIEKETKLNELTNKYEA---LKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
++ + +L+ E+ +L LT + E + + +A+++D LE + + L + +L +
Sbjct: 2640 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT--K 2697
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI 822
+ ++ + + G++NR GE L + K S
Sbjct: 2698 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2757
Query: 823 SVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
+ + E S+LK+ L C + D E+ ++ +E AEY E A K + L
Sbjct: 2758 DQLKELTLENSELKKSL-DCMHK--DQVEKEGKVREEI---AEYQLRLHE--AEKKHQAL 2809
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN--KR 938
L+ +N + ++ Q E+ + + E+ + + +D + E N K
Sbjct: 2810 LLD---TNKQYEVEIQTYREK--------LTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2858
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ +EEL+ K D V +++K E+ K K K+LE+ K L++ + +
Sbjct: 2859 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2918
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALE 1027
E+ +T + +E +KE K LE
Sbjct: 2919 QEKQKTGTVMDTKVDELTTEIKELKETLE 2947
Score = 72.1 bits (169), Expect = 1e-11
Identities = 184/941 (19%), Positives = 371/941 (39%), Gaps = 74/941 (7%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKE 167
L ++K ENL I++ +++ ++ EL + +M + L K
Sbjct: 1868 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI 1927
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYD-NTLSKL 226
V +LKK N L++K LE + + + + + E L L + D ++ +
Sbjct: 1928 VGELKKENSDLSEK---LEYFSCDHQ------ELLQRVETSEGLNSDLEMHADKSSREDI 1978
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++ N S + + +++EL R + + + ++ LE+ + L
Sbjct: 1979 GDNVAKVNDSWK-ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-----LE 2032
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
++NE + K + + E + S QL ++ SKK+ +D+ + + + T
Sbjct: 2033 KDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT-TALDQLSEKM------KEKTQ 2085
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
L+ + + I + ++ E E + D++E + + EKL SL +
Sbjct: 2086 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE----KDSQ 2141
Query: 404 ACNILRIQKE-RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
A ++ + + E +I +++ + +VK+ L+ L++ + K+++ + L+ L
Sbjct: 2142 ALSLTKCELENQIAQLNKEKEL-LVKESESLQARLSESDYE----KLNVSKALEAALVEK 2196
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEE 520
+ + + TQ E+ + IEK ++R+E K + D +E
Sbjct: 2197 GEFALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2254
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
E++ + EE +L + + A + +K EE+ A + + + + L SEK+N
Sbjct: 2255 LERELQ-MSEENQELVILDAENSKAEVETLKTQIEEM-ARSLKVFELDLVTLR-SEKENL 2311
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREK--ETQASELERSCQVIKQNGF-ELDKMKADI 637
++ L E + L S ++ ++ E Q E ++ + QN EL++ A +
Sbjct: 2312 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2371
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLE--QNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+E L + L + + +EK + C + +K E A++
Sbjct: 2372 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADL 2429
Query: 696 QNRMIMRLQKQIQ----EDDKLFIEKETKLNE---LTNKYEALKRDYDAAVKDLESSREA 748
+ L+++++ + +E E E L K E + + D+ + R
Sbjct: 2430 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2489
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
LT + + RI+ELE + + T E +
Sbjct: 2490 KEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2549
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
D ++ S+V L+ Q LD+ K Y L +QE
Sbjct: 2550 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN---GLIQEV 2606
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVD-R 926
++ +L+K+ ++++S LK QI+ Q Q V + ++ E L ++ V+
Sbjct: 2607 EDGKQKLEKK----DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2662
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKN--TVTKMQK-----AMEKYTKKDKEFEAKRK 979
KN L T+E L+ ++L+N +TKM K + K T K+ E + +
Sbjct: 2663 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2722
Query: 980 ELEDCKAEL-EELKQRYKELDEECETCAEYLKQREEQCKRL 1019
E+ AEL EEL L E + E +K ++Q K L
Sbjct: 2723 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2763
Score = 67.7 bits (158), Expect = 2e-10
Identities = 177/964 (18%), Positives = 398/964 (41%), Gaps = 90/964 (9%)
Query: 55 ISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS 114
+S KM + +E + + L + ++KE+ L+ ++ + + L +++S
Sbjct: 2076 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS 2135
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD----- 169
LE ++ L + + +K+ L +E+++L + E+ E N++K ++
Sbjct: 2136 LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2195
Query: 170 ------DLKKNNECLTQKCIDLEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDN- 221
L E + Q +EKL V ++ +I + K +E SL +N
Sbjct: 2196 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENL 2255
Query: 222 ----TLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
+S+ N+ + + ++ TL+++++ K D ++++ E N+
Sbjct: 2256 ERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE----NL 2311
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
T + EK G+ +E + K++S K L EQ ++SK ++ ++ L + +
Sbjct: 2312 TKQIQEKQGQLSELD----KLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQLKELNE 2366
Query: 338 AEFGTTSLDVFEILMD-NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A V + D I+ + LD +E+ +++ + + + L++ +K +
Sbjct: 2367 A--------VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2418
Query: 397 QLIEKENACNILRIQKERI-HEISSAVTID---IVKKENELKEILTKECLKLSKLKIDIP 452
QL E E+ ++L+ + E + E+ A T ++ EN E+ T + K+ + +
Sbjct: 2419 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA-KIEGMTQSL- 2476
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
R L+ D+ +TI + EL + I + ++ + + +
Sbjct: 2477 RGLELDV-----VTIRSEKEDLTNELQKEQERISELEI-INSSFENILQEKEQEKVQMKE 2530
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+E ++K L+E + L+ + N LS +++ L++ + + +
Sbjct: 2531 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN----LSSQVECLEL---EKAQLLQ 2583
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L E N L S++NGL +E K +K+ + S L+ Q +Q +L +
Sbjct: 2584 GLDEAKNNYIVLQSSVNGLIQEVEDGKQK----LEKKDEEISRLKNQIQDQEQLVSKLSQ 2639
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL--EINIKTHE 690
++ + + + + L +N +L++ E L E+ + +
Sbjct: 2640 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2699
Query: 691 KTAEIQ--NRMIMRLQKQIQEDDKLFIEKETKL-NELTNKYEALKRDYDAAVKDLESSRE 747
K + ++ N+M + + ++Q + +K +L EL+ + L + +++++SS++
Sbjct: 2700 KMSFVEKVNKMTAK-ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2758
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ +LT + ++ + + D + E+ V E
Sbjct: 2759 QLKELTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQLRL-------------HEAEK 2804
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAEYLQ 866
+ LD + + + + + E KE LS Q+ E+D LK +EL++ + + L+
Sbjct: 2805 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2864
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
E LKK K+ + V+ LK++ + + + K + E+ + + +
Sbjct: 2865 E-------LKKTKMDNLKYVNQLKKE---NERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2914
Query: 927 MSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
+ E +K +M T ++EL + ++LK T+ + K ++Y K ++LE K
Sbjct: 2915 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2974
Query: 986 AELE 989
LE
Sbjct: 2975 EMLE 2978
Score = 63.7 bits (148), Expect = 4e-09
Identities = 141/735 (19%), Positives = 298/735 (40%), Gaps = 54/735 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL----E 116
++LK E+ L+ +L ++ +K L + Q + D L+S KSL E
Sbjct: 2281 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2340
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINEL-------QEENDTLSNLIMENVTESDNLNKEVD 169
+ +E K + L+ + K++NE QE + + E L ++
Sbjct: 2341 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2400
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTL-SKLNR 228
L+ E +K + + + + ESE+ + ++ ENL + L I N + L
Sbjct: 2401 KLRARLEADEKKQLCVLQQLKESEHHAD----LLKGRV-ENLERELEIARTNQEHAALEA 2455
Query: 229 SISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGE 287
S T KI + L D + + + N L+ + ++ +++ E
Sbjct: 2456 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFE 2515
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-LD 346
N E + KV + K +S + +++ + K+ + + + A E +S ++
Sbjct: 2516 NILQEKEQEKVQMKEK---SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2572
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE-------LKSVNEKLASLNSQLI 399
E+ ++ LDE Y +Q +N E L+ +E+++ L +Q+
Sbjct: 2573 CLELEKAQLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2628
Query: 400 EKENACNILRIQKERIHEISSAVTIDI----VKKENELKEILTKECLKLSKLKI--DIPR 453
++E + L Q E H++ +++ V+ E +++ + +K L++ +
Sbjct: 2629 DQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2687
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA-VXXXXXXXXXXXX 512
+L+ +L K + F + + T+ + E ++ +T + +
Sbjct: 2688 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2747
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ ++ + +++K L E ++L KS + + + EEI ++ + + E+K
Sbjct: 2748 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ 2807
Query: 573 SLSEKDNKLTEL-VSTINGL---KEENNSLKSLN-DVITREKETQASELERSCQVIKQNG 627
+L NK E+ + T KEE S + L D++ KE + L+ + Q+++
Sbjct: 2808 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE--- 2864
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
EL K K D L + K L++ L+E+ E ++ S+L+ +
Sbjct: 2865 -ELKKTKMDNLKYVNQLKKENERAQG---KMKLLIKSCKQLEEEKEILQKELSQLQA-AQ 2919
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+KT + + + L +I+E + EK + +E +KY +L ++ K E
Sbjct: 2920 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2979
Query: 748 AVNQLTTQKDLVEGR 762
V L +Q+ + R
Sbjct: 2980 QVAHLCSQQSKQDSR 2994
Score = 61.7 bits (143), Expect = 1e-08
Identities = 190/989 (19%), Positives = 410/989 (41%), Gaps = 110/989 (11%)
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+D LK N+ L K +LE + E ++ G N + +L+ + I + L+K
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ T+ +Y++ T + L+ + K+L ED + + + E ++ + EK
Sbjct: 340 RDELV--RTTAQYDQASTKYTALE---QKLKKLTEDLSCQRQNAESARCSLEQKIKEK-- 392
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
EF+ + +S +R+ +L ++ I +++ +++ + + K+ + VL AE L
Sbjct: 393 -EKEFQEE----LSRQQRSFQTLDQECIQMKARLTQE-LQQAKN-MHNVLQAELD--KLT 443
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLI---- 399
+ ++N + +++ L + + Q +L E+K N L S + Q
Sbjct: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 400 ----EKENACNILRIQKERIHEISSAVTI------DIVKKENELKEILTKECLKLSKLKI 449
E +N L + E+ + T D+ +K N+ + LT E LKL+ +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 450 DIPRDLDQDLPAHKK--ITILFD----------ALITQYELSRTDYEIEKEKLRLET--- 494
+ RD QDL ++ I L D AL++ EL + +YE KE+ L +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEA--HNEVKSLHEELTKLYKSKVDENNANL---NL 549
+ + + LE ++KS HE ++ ++D N ++ NL
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLETCLKTQQIKS-HEYNERVRTLEMDRENLSVEIRNL 682
Query: 550 IKIL---SEEIDALKIAIAKNEEKMLSLSEKDNKLTELV----STINGLKEE-NNSLKSL 601
+L S E++ K+A + ++K +K K E + S + G E+ + L+ L
Sbjct: 683 HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
Query: 602 -NDVITREKETQA--SELERSCQVIKQNGFEL--DKMKADILMXXXXXXXXXXXXXXXXD 656
N+++ +++ Q +E E ++K L ++ L+
Sbjct: 743 SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
E S+ + + + ++ ++ + L+ + + E + E Q +M LQKQ +E ++ E
Sbjct: 803 EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK-DLVEGRIAELE---SDIRT 772
E L + +++ + + L+ A + + +E + EL+ + T
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
Query: 773 EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQ 832
EQ T E +++ L+ KR I ++ E
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN---KREIEELTQ-ENGT 978
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQ---Q 885
LKE S QE +L ++ E+ A Y+ ER++ + L K+EKL L Q +
Sbjct: 979 LKEINASLNQEKMNLIQK-------SESFANYIDEREKSISELSDQYKQEKLILLQRCEE 1031
Query: 886 VSNLKEQI--RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
N E + + + E+ +K + +N ++++ +A ++++ + +
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKL-ECLLNECTSLCENRKNELEQLK-EAFAKEHQEFLTKL 1089
Query: 944 EELRYKKQDLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ Q+L + +Q+A+ + E ++E+ K E ++++ +L
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-----NQKVALEKQIESLSNTPVSN 1053
+E E + +K + E C+ L+ I + ++ S N K ++ +++ +S + +
Sbjct: 1150 LQENEQLMKVMKTKHE-CQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS---LDS 1205
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ A+++N+++ ++E++K K+
Sbjct: 1206 YNAQLVQLEAMLRNKELK--LQESEKEKE 1232
Score = 61.7 bits (143), Expect = 1e-08
Identities = 190/970 (19%), Positives = 386/970 (39%), Gaps = 75/970 (7%)
Query: 114 SLEMENLTKD-------KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
SL+ ENLT+ K ++ L + + + +L+E+ + S IM+N E L +
Sbjct: 1626 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME--SQGIMKN-KEIQELEQ 1682
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+ ++ +CL ++ + + + + K+ + + KL Q+ + + +++L
Sbjct: 1683 LLSSERQELDCLRKQYLSENE---QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1739
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ + S+R + + E C E + H+ + D D +
Sbjct: 1740 Q--LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQD 1797
Query: 287 ENNEFE----TKAVKVMSEI--KRNLNSLSEQLINNESKKSKDHIDRYKDS---LLAVLD 337
N + E T AVK E +++ ++ E ++++ S + I S L +D
Sbjct: 1798 LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMD 1857
Query: 338 AEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ ++ + N+ L I ++ KV+ LNE +K ++ KL Q
Sbjct: 1858 FLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE----MKELDSKLHLQEVQ 1913
Query: 398 LIEKENAC----NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L+ K AC I+ K+ ++S + + L+ + T E L S L++ +
Sbjct: 1914 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN-SDLEMHADK 1972
Query: 454 DLDQDLPAH-KKITILFDA--LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXX 510
+D+ + K+ + L + ELSR I EK +E
Sbjct: 1973 SSREDIGDNVAKVNDSWKERFLDVENELSR----IRSEKASIEHEALYLEADLEVVQTEK 2028
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
D E + L EEL+ + E N + +S++ AL K +EK
Sbjct: 2029 LCLEKDN-ENKQKVIVCLEEELSVV----TSERNQLRGELDTMSKKTTALDQLSEKMKEK 2083
Query: 571 MLSLSEKDNKLTELVSTING-LKEENNSLKSLN-DV--ITREK---ETQASELERSCQVI 623
L ++ + +KE+ L++L+ DV + ++K + + LE+ Q +
Sbjct: 2084 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2143
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK-SLLEQNLALKEQCEEKTRDCSRL 682
EL+ A + E+ L + AL+ EK RL
Sbjct: 2144 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2203
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
T E+ +++ R I +L+ +I+ D+K + KL E + ++LK + ++L
Sbjct: 2204 S---STQEEVHQLR-RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2259
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ S E NQ D E AE+E+ ++T+ +
Sbjct: 2260 QMSEE--NQELVILD-AENSKAEVET-LKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 2315
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET- 860
++ L E KL S K + +E+ Q+KE + ++ L+ + KEL++
Sbjct: 2316 QEKQGQLSELDKLLSSFKSLLEEKEQAEI-QIKEE---SKTAVEMLQNQLKELNEAVAAL 2371
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VNTDEDWANL 919
C + QE + + + E Q+ N E++R + + + + + + E A+L
Sbjct: 2372 CGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL 2429
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
V+ + + E+ + + +E K +++ K++ + + + R
Sbjct: 2430 LKGRVENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2488
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-AKIALEIVDKLSNQKVA 1038
E ED EL++ ++R EL+ + L+++E++ ++KE + A+E+ L Q
Sbjct: 2489 EKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM---LQTQLKE 2545
Query: 1039 LEKQIESLSN 1048
L +++ +L N
Sbjct: 2546 LNERVAALHN 2555
Score = 58.8 bits (136), Expect = 1e-07
Identities = 198/1024 (19%), Positives = 398/1024 (38%), Gaps = 99/1024 (9%)
Query: 59 MCQSLKESSN--EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLE 116
M + L+E N E +L LEKL + D+++Q+ ++DLL + +E
Sbjct: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC-------------SQDLLKKREHHIE 582
Query: 117 MEN--LTK-DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK 173
N L+K +KE K L +L+ K K+ EL+EE S EN + E ++L+
Sbjct: 583 QLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQS 642
Query: 174 NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDS 233
L + C+ +++ + N + + +ENL S+ I L+ +
Sbjct: 643 KINHL-ETCLKTQQIKSHEYN----ERVRTLEMDRENL--SVEI------RNLHNVLDSK 689
Query: 234 NTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
+ K+ ++ + A +F+ K+ E+ NM + + G+ + E
Sbjct: 690 SVEVETQKLAYMELQQKA----------EFSDQKHQKEIE--NMCLKTSQLTGQVEDLEH 737
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
K + +EI Q ++ E + +D + SL+ D + + D +
Sbjct: 738 KLQLLSNEIMD--KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHH 795
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
+ N + + + ++ + + ++ + ++ SL L ++ + L+ Q E
Sbjct: 796 SFANIIG-EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID-------IPRDLDQDLPAHKKIT 466
+ +I + +++K E + + + ++SKL+ D + L K++
Sbjct: 855 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Query: 467 ILFDALITQ----YELSRTDYEIEK--EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+L D + T+ EL ++++ +E ++L+L + T + L +
Sbjct: 915 LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL---SEK 577
+ +K ++ L + + + ++ + N I + I +++ +EK++ L E
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS--ELSDQYKQEKLILLQRCEET 1032
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N +L +E+N+ L+ L + T E + +ELE+ +K+ K +
Sbjct: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ----LKE---AFAKEHQEF 1085
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
L + + L + Q K+ + L+ I T E QN
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMT-DNQNNSKS-EAGGLKQEIMT---LKEEQN 1140
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+M + +QE+++L +TK +E N R+ +VK+ ES R N Q D
Sbjct: 1141 KMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRN---SVKERESERNQCN-FKPQMD 1195
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDEN-RDLGENPKLDD 816
L + E+ D Q + + R E L D
Sbjct: 1196 L---EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQD 1252
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
+ IS + D E+ +E+ +S EL + L +T L E ++ C L+
Sbjct: 1253 MQSQEISGLKDCEI-DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
Query: 877 KEKLSLEQQVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYDAEV 933
EK L ++++ + + T++ E K + ++D LH +V D +
Sbjct: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
Query: 934 EKNKR----LMKTIEELRYKKQDLKNTVTKMQKA--MEKYTKKDKEFEAKRKELEDCKAE 987
+ N++ L E Y+ L + +M A EK+ E + + ++
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSK 1431
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE--IVDKLSNQKVALEKQIES 1045
+ EL+ L E + L R Q +KE ++ LE +V LS+ V + S
Sbjct: 1432 MSELQTYVDSLKAENLVLSTNL--RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSS 1489
Query: 1046 LSNT 1049
L ++
Sbjct: 1490 LGDS 1493
Score = 56.0 bits (129), Expect = 7e-07
Identities = 186/857 (21%), Positives = 341/857 (39%), Gaps = 91/857 (10%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-----I 302
EL D E E F+ +H EL + T + G N++ E A K E +
Sbjct: 1930 ELKKENSDLSEKLEYFSC--DHQELLQRVETSE-----GLNSDLEMHADKSSREDIGDNV 1982
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAV-LDAEFGTTSLDVFEILMDNIINKYQI 361
+ +S E+ ++ E++ S+ ++ A+ L+A+ + + DN NK ++
Sbjct: 1983 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE-NKQKV 2041
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEIS 419
+ + E+ + V + N+ EL ++++K +L+ QL EK E + Q E +H I
Sbjct: 2042 IVC-LEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEKTQELESHQSECLHCIQ 2099
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
A VK++ EL + L+ + +L K K + L Q L + L T+ EL
Sbjct: 2100 VAEAE--VKEKTELLQTLSSDVSELLKDKTHLQEKL-QSLEKDSQALSL-----TKCELE 2151
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
++ KEK L V ++ L N K+L L + +
Sbjct: 2152 NQIAQLNKEKELL-------VKESESLQARLSESDYEKL----NVSKALEAALVEKGEFA 2200
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+ ++ + + L I+ L++ I +E+K L ++EK + + EN+SLK
Sbjct: 2201 LRLSSTQEEVHQ-LRRGIEKLRVRIEADEKKQLHIAEK----------LKERERENDSLK 2249
Query: 600 SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK 659
+ V E+E Q SE + ++ + + KA++ +
Sbjct: 2250 --DKVENLERELQMSEENQELVIL-----DAENSKAEVETLKTQIEEMARSLKVFELDLV 2302
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-E 718
+L + L +Q +EK S L+ + + + E + + + QI+E+ K +E +
Sbjct: 2303 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA----EIQIKEESKTAVEMLQ 2358
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
+L EL AL D + +S + + ++ +E A LE+D + +Q +
Sbjct: 2359 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK-KQLCVL 2417
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
+ R E+ L+ S EV LK ++
Sbjct: 2418 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-------SKGEVETLKAKIE 2470
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
Q L L+ + E E LQ+ E+ + L+ S E + KEQ + Q
Sbjct: 2471 GMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQE-KEQEKVQ-- 2527
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ ++ A + T N V +A K + L +E L +K L +
Sbjct: 2528 MKEKSSTAMEMLQTQLKELN-ERVAALHNDQEACKAKEQNLSSQVECLELEKAQL---LQ 2583
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
+ +A Y +E+ED K +LE+ DEE ++ +E+ +
Sbjct: 2584 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK-------KDEEISRLKNQIQDQEQLVSK 2636
Query: 1019 LK----EAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGS-AIVQNQ-QIT 1071
L E ++ E +L N V LE++I+ L + S T+ V S ++N+ ++T
Sbjct: 2637 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2696
Query: 1072 --DVMKENQKLKKMNAK 1086
D M +K+ KM AK
Sbjct: 2697 KMDKMSFVEKVNKMTAK 2713
Score = 44.0 bits (99), Expect = 0.003
Identities = 55/254 (21%), Positives = 106/254 (41%), Gaps = 22/254 (8%)
Query: 847 LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+KE+ KE +E Q D++C ++K QQ N+ + Q +++
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVL--QAELDKLTSVK 446
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
N E++ + ++ A K L +++EE++ + LK+ QKA E
Sbjct: 447 QQLENNLEEFK--QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS--HSEQKAREV 502
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQR---EEQCKRLKEAK 1023
EA+ K ++ C + + + K + ET L+++ +E L++ K
Sbjct: 503 C-----HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 1024 IALEIVDKLSNQKVAL----EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
+A+ ++K + L E IE L++ A SA+ ++ + +KE +
Sbjct: 558 LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 1080 L----KKMNAKLIT 1089
L K N KL+T
Sbjct: 618 LFSCWKSENEKLLT 631
>BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein
protein.
Length = 1694
Score = 87.4 bits (207), Expect = 2e-16
Identities = 201/1036 (19%), Positives = 426/1036 (41%), Gaps = 76/1036 (7%)
Query: 80 ELFDIKEQKSALEGKYQ---NLILETQTRDLLMSQ--IKSLEMENLTKDKEIKNLTDSLK 134
EL D +E+ LE Q + ++ET + Q I+ L++E + K+++ L D +K
Sbjct: 1 ELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIK 60
Query: 135 TKSKKINELQEENDTL----SNLIMEN---VTESDNLNKEVDDLK----KNNECLTQK-- 181
+KK++ + + D L L +E + E +NL E L+ K ++ +T+K
Sbjct: 61 DINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKER 120
Query: 182 ----------CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
L++ ++++EN+I + Q +L+ +L++ L+ Y+ S R IS
Sbjct: 121 ILAQSASVEEVFRLQQALSDAENEIMRLSSLNQEELQMSLLK-LNNEYEVIKSTATRDIS 179
Query: 232 -DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
DS + + EL+ + + L + + + +M + D+ + NE
Sbjct: 180 LDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 239
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSK--DHIDRYKDSLLAVLDAEFGTTSLDVF 348
++ ++S++K++LN +++ E K +D K+ L+ +E L +
Sbjct: 240 GDS----IISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLI---QSEVALNDLHLT 292
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ +++ + L++ E +Q + E ++ E+L+ + ++L++ N +
Sbjct: 293 KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNS 352
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI- 467
+ + E + V ++ + +EL+++ E LK K+ D+ + ++ + A + +
Sbjct: 353 NFKDTLLKEREAEVR-NLKQNLSELEQL--NENLK--KVAFDVKMENEKLVLACEDVRHQ 407
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD-TLEEAHNEVK 526
L + L +LS I E L++E G +A ++ T+EE N +
Sbjct: 408 LEECLAGNNQLSLEKNTIV-ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSN-AR 465
Query: 527 SLHEELTKLYKSKVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+L+ +L + + N ++ I L + I+ + + ++ + S E+ +LT+L+
Sbjct: 466 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 525
Query: 586 ST----INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI--LM 639
+ I LKE ++ L+ D ++ + +E+ R Q I++ L MK + L
Sbjct: 526 NKKEIFIEKLKERSSKLQEELDKYSQA--LRKNEILR--QTIEEKDRSLGSMKEENNHLQ 581
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ K+L + L + + LE IK H+K E QN+
Sbjct: 582 EELERLREEQSRTAPVADPKTL-DSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQS 640
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
M+L + +QE K E + ++ + L + D +K L+ + + Q+ TQ
Sbjct: 641 KMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQ---KTIEQIKTQLHEE 697
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD--- 816
I SDI ++T G + R+L E L++
Sbjct: 698 RQDIQTDNSDI-FQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL-EIKLLNEKNI 755
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
S + I +S EV +L + + E+ L R + YLQ++ + A +
Sbjct: 756 SLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVV--YLQQQLQAYAMER 813
Query: 877 KEKLSLEQQVSNLKEQIRTQQPVERQAKFA-DVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
++ ++ + + ++T+ A + A+ +D S + D E
Sbjct: 814 EKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET 873
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
+ L + I E + L + ++ + ++ + E+ E + LKQ+
Sbjct: 874 IQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDTLKQQV 933
Query: 996 KELDEECETCAEYLKQREEQCKRLKEAKIALE---IVDKLSNQKVALEKQIESLSNTPVS 1052
K+++E + ++ + + +L+E L+ +VD +N K L+ L +
Sbjct: 934 KKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSK--LQVDYTGLIQSYEQ 991
Query: 1053 NSTMYVATGSAIVQNQ 1068
N T G + Q Q
Sbjct: 992 NETKLKNFGQELAQVQ 1007
Score = 68.1 bits (159), Expect = 2e-10
Identities = 189/1067 (17%), Positives = 436/1067 (40%), Gaps = 101/1067 (9%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDI-----KEQKSALEGKYQNLILETQTR--DLLMS 110
K+ QS + + N+++L +KL ++ ++ K Q+S + + +NL L+ R + +S
Sbjct: 278 KLIQS-EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 336
Query: 111 QIKSLEMENLTKDKEIKNLTDSL--------KTKSKKINELQEENDTLSNLIMENVTESD 162
+I++ M++L +D N D+L + + ++EL++ N+ L + + E++
Sbjct: 337 RIRNELMQSLNQDSN-SNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENE 395
Query: 163 NLNKEVDDLKKN-NECLT-QKCIDLEKLVNESENKIGPKNICAQ-CKLKENLIQSLHIGY 219
L +D++ ECL + LEK K+ I A+ C K+ L++ + Y
Sbjct: 396 KLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEAN-KY 454
Query: 220 DNTLSKLN--RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
+ T+ +L+ R+++ S + + L + D + K+ E + +H E + +
Sbjct: 455 EKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDT--DHKETKDV-L 511
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRY----KDSLL 333
+ L+E+ K + + ++K + L E+L K+ I R KD L
Sbjct: 512 SSSLEEQKQLTQLINKKEIFI-EKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSL 570
Query: 334 AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
+ E ++ E L + + + L+ T++ ++++ + + + E++
Sbjct: 571 GSMKEENNHLQEEL-ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKH 629
Query: 394 LNSQLIEKENACNI-----LRIQKERI------HEISSAVTIDI-VKKENELKEIL-TKE 440
+ ++IE +N + L+ QK+ + HE +A + ++K+ E+K + T E
Sbjct: 630 -HQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 688
Query: 441 CLK--LSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE-----IEKEKLRLE 493
+K L + + DI D K ++ + +++LS+ + E I++ +L ++
Sbjct: 689 QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIK 748
Query: 494 TGTAKAVXXXXXXXXXXXXXX---FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
K + +++ E+++LH ++ ++ D L
Sbjct: 749 LLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQ-DVVYLQQQLQ 807
Query: 551 KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING----LKEENNSLKSLNDVIT 606
E + K E L + +K+ ++V+ L++EN L + + +
Sbjct: 808 AYAMEREKVFAVLNEKTRENS-HLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE--S 864
Query: 607 REKETQASELERSCQVIKQNGFELDKMKAD---ILMXXXXXXXXXXXXXXXXDEAKSLLE 663
++ ++ ++I++ E+D + +L ++ + LL+
Sbjct: 865 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 924
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
+ LK+Q ++ ++ ++ + ++A++Q + +LQ Q+ D + +
Sbjct: 925 ERDTLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL-HQLQAQVLVDSDNNSKLQVDYT 983
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI----AELES-DIRTEQTAT 777
L YE + ++L + ++ QL KDL+ G++ +L S + T Q+A
Sbjct: 984 GLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE 1043
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGD--ENRDLGENPKLDDSPKRSISVISDSEVS---- 831
+ +D +++ + S S+ + SE+
Sbjct: 1044 CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1103
Query: 832 -QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLK 890
Q + +++ D L++ KE D + ++ L +E E L Q V+NLK
Sbjct: 1104 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLK 1163
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKK 950
E+I + D+ E+ + + Y A E N + + E ++
Sbjct: 1164 ERILILE--------MDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC 1215
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
+K ++ + K+KE + K EL ++ ++++ +E + LK
Sbjct: 1216 HSMKEKALAFEQLL-----KEKE-QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALK 1269
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
Q++ + L+ +V +L +++ +++E L N + + Y
Sbjct: 1270 QKQMENTALQ------NVVQRLRDKEFRSNQELERLRNHLLESEDSY 1310
Score = 68.1 bits (159), Expect = 2e-10
Identities = 191/1086 (17%), Positives = 438/1086 (40%), Gaps = 88/1086 (8%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R+QL+ + N+ + ++ ++ I ++C + K E N K EK EL +
Sbjct: 405 RHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEAN-KYEKTIEELSN 463
Query: 84 IKE-QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ SAL+ ++++LI Q +D+ ++++K + T KE K++ S + K++ +
Sbjct: 464 ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 523
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L + + + E S L +E+D K ++ L + I L + + E + +G
Sbjct: 524 LINKKEIFIEKLKER---SSKLQEELD---KYSQALRKNEI-LRQTIEEKDRSLGSMKE- 575
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICTLQSELDAGREDCKELC 260
L+E L + L T + DS T ++ +++ T++ L+ + +++
Sbjct: 576 ENNHLQEEL-ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKII 634
Query: 261 EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQL 313
ED K L ++DE ++ + ++ E +++ + + QL
Sbjct: 635 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 694
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII-------------NKYQ 360
D+ D ++++ + L+ E G+ D+ + + ++ N+
Sbjct: 695 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN 754
Query: 361 IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEIS 419
I L + +++ +K ++ + T ++ + ++ +L++++ + +++ +Q++ + + +
Sbjct: 755 ISLTKQIDQLSK--DEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME 812
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL------I 473
++ ++ L E K+ + L + +KK++ F++
Sbjct: 813 REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRE 872
Query: 474 TQYELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
T LSR + +IE + L + T AV + EE E +L ++
Sbjct: 873 TIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDTLKQQ 932
Query: 532 LTKL--YKSKVDENNANLNLIKI-LSEEIDALKIAI---AKNEEKML--------SLSEK 577
+ K+ +K +V N+ L EE+ L+ + + N K+ S +
Sbjct: 933 VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQN 992
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
+ KL + ++ L + D++ + + + +L + + Q+ L K+++
Sbjct: 993 ETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1052
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
L + KSL E++ ++ E R + + K E +
Sbjct: 1053 L-----SESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1107
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
I +L+++ KL EK+ + +++ + ++ V + E R+AV L +
Sbjct: 1108 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL 1167
Query: 758 LVEGRIAELESD----IRTEQ-TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++E I +L+ + + T + T + + L
Sbjct: 1168 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1227
Query: 813 KLDDSPKRSISVISD--SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE-RD 869
L + + ++ + V ++E+ + QQE D + K+ E +Q RD
Sbjct: 1228 LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNVVQRLRD 1287
Query: 870 EQC-ARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD 925
++ + + E+L LE + S +E + + +R+AK +E + S ++
Sbjct: 1288 KEFRSNQELERLRNHLLESEDSYTREALAAE---DREAKLRKKVTVLEEKLVS-SSNAME 1343
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA-----KRKE 980
S+ A V+ + L + + + ++ + ++ Q+ +++Y + +++E
Sbjct: 1344 NASHQASVQV-ESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEE 1402
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALE 1040
AELE+ KQ E + E + +E C L EA AL+ +L+ Q E
Sbjct: 1403 KAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE-C--LDEANAALDSASRLTEQLDVKE 1459
Query: 1041 KQIESL 1046
+QIE L
Sbjct: 1460 EQIEEL 1465
Score = 59.3 bits (137), Expect = 8e-08
Identities = 98/478 (20%), Positives = 202/478 (42%), Gaps = 61/478 (12%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM---------IMRLQKQI 707
E + L + + E+CE +CS+L+ + T + R+ + RLQ+ +
Sbjct: 79 EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAL 138
Query: 708 QEDDKLFI--------EKETKLNELTNKYEALK----RDY--DAAVKDLESSREAVNQLT 753
+ + + E + L +L N+YE +K RD D+ + DL + EA Q
Sbjct: 139 SDAENEIMRLSSLNQEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQEL 198
Query: 754 TQK-DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
Q E IAE+E R Q AT + D E
Sbjct: 199 NQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND--EKK 256
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
++ + + + +V KE+L+ + L+DL ++L+D+ E + L + E
Sbjct: 257 RVHQLEDDKMDITKELDVQ--KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESN 314
Query: 873 ARLKKEKLSL-------EQQVSNLKEQIRTQQPVERQAKFADVAV--------NTDEDWA 917
++KE L L E+++S ++ ++ + + F D + N ++ +
Sbjct: 315 VSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS 374
Query: 918 NLHSV--VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L + + ++++D ++E N++L+ E++R++ ++ Q ++EK T E
Sbjct: 375 ELEQLNENLKKVAFDVKME-NEKLVLACEDVRHQLEEC--LAGNNQLSLEKNT----IVE 427
Query: 976 AKRKELEDCKAELEELKQR-YKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLS 1033
+ E + +AEL K+R +E ++ +T E R L+ E + +++ K
Sbjct: 428 TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 487
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN----QKLKKMNAKL 1087
+ L+K IE + + S++ + +Q+T ++ + +KLK+ ++KL
Sbjct: 488 MEIAELKKNIEQMDTDHKETKDV---LSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 542
Score = 41.1 bits (92), Expect = 0.021
Identities = 46/219 (21%), Positives = 96/219 (43%), Gaps = 13/219 (5%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
V +L+++ QEL+ L+ E +D A ++R+ A+L+K+ LE+++
Sbjct: 1282 VQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE---AKLRKKVTVLEEKL--- 1335
Query: 890 KEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV--EKNKRLMKTIEELR 947
+ + +E + A V V + ++ N+ S D + V E+ K+ ++ L+
Sbjct: 1336 ---VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQ 1392
Query: 948 YKKQDLKNTVTKMQKA-MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
+ + M A +EK + E++ + LE L+E +
Sbjct: 1393 MVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLT 1452
Query: 1007 EYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALEKQIE 1044
E L +EEQ + LK + ++ E++D + + ++L E
Sbjct: 1453 EQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1491
>AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 protein.
Length = 1357
Score = 87.4 bits (207), Expect = 2e-16
Identities = 213/1077 (19%), Positives = 421/1077 (39%), Gaps = 116/1077 (10%)
Query: 48 QDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ--- 103
+D+ CK + Q + N+ + ++ + ++++ + + K ETQ
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQ 405
Query: 104 -----TRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK-SKKINELQEENDTLSNLIMEN 157
R+ + ++I L+ EN + N T+ L++K S ++N+L+++ L N + E
Sbjct: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
Query: 158 V-------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK 208
+ N + LK + ++ +++ + + +E++ +++ ++ K
Sbjct: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK 525
Query: 209 ENLIQSLHIGYDNTL---SKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDF 263
EN +QSLH +TL +L + + + R NK +LQ ++ E + L
Sbjct: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
Query: 264 TSIKNHL--ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESK 319
+ + + + +L + + E ++ + ++ + L S E+L I N +
Sbjct: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K + + + A + + D+ I + L + + LN+
Sbjct: 646 LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 705
Query: 380 CTSELKSVNEKLASL-----NSQLIEKENACNILRIQK-ERIHEISSAVTIDIVKKENEL 433
LKS +KL +L N ++E+ C + +K + + E+ I + KE EL
Sbjct: 706 QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
I T+ S L ++ QDL A + + F +L+ EL + +E +
Sbjct: 766 NAIRTEN----SSLTKEV-----QDLKAKQNDQVSFASLVE--ELKKVIHE--------K 806
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
G K+V T+++ E+K+L EE+ + K + L++ +
Sbjct: 807 DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ----LSITSKV 862
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKE 610
E + LK + L EK+ L + L+EEN SLK+ + + ++
Sbjct: 863 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 922
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ AS+ E V+K+ EL +++A + DE K Q LK+
Sbjct: 923 SSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
Query: 671 QCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA 730
Q ++ + HE+ L K I E +K E NEL + +A
Sbjct: 983 QNYQQAS-------SFPPHEE-----------LLKVISEREK---EISGLWNELDSLKDA 1021
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
++ E + EA+ L + + +++ ++ + + R +Q V
Sbjct: 1022 VEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE-RQQQVEAVELEAKEVLKKLF 1080
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLK-- 848
++G+ + K ++ S SE ++ E L E+ L
Sbjct: 1081 PKVSVPSNLSYGEWLHG------FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQL 1134
Query: 849 --ERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
E+YK + E E + LQ EQ K K+ +++ +K+ Q +
Sbjct: 1135 ECEKYKSVLAETEGILQKLQRSVEQ--EENKWKVKVDESHKTIKQM---QSSFTSSEQEL 1189
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAME 965
+ + ++D NL +R + E+EK + T + E+R +LK+ +T++QK
Sbjct: 1190 ERLRSENKDIENLRR---EREHLEMELEKAEMERSTYVTEVR----ELKDLLTELQK--- 1239
Query: 966 KYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIA 1025
K E + +EL KA+L E + + E + A L + +Q L ++KI
Sbjct: 1240 KLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL-HKAQQSLELIQSKIV 1298
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
K + +E S TM V+ + Q QQ+ + NQ+L K
Sbjct: 1299 -----KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV--NQQLTK 1348
Score = 65.3 bits (152), Expect = 1e-09
Identities = 121/596 (20%), Positives = 255/596 (42%), Gaps = 45/596 (7%)
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTEL 584
KS ELT L +++ L+ + E+ A K + ++M++ E+ N +T +
Sbjct: 321 KSSKGELTTLIHQLQEKDK----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM 376
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI-LMXXXX 643
I L++E+N + N + +ETQ +++ QV +Q E+ +K + ++
Sbjct: 377 KDRIGTLEKEHNVFQ--NKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAV 433
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E L + L + EKT + E+ K E+ A +L
Sbjct: 434 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-------QL 486
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRD----YDAAVKDLESSREAVNQLTTQKDLV 759
+ Q+QE ++ + E ++ + + T ++EA ++D + A +++S + K +
Sbjct: 487 KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL 546
Query: 760 EGRIAEL-ESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD--LGEN-P 812
E R+ +L ES+ + E++ + + L E
Sbjct: 547 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH 606
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
K+ + I DS S+ ++RL S ++EL D++ L E + E+
Sbjct: 607 KVIAEKDKQIKQTEDSLASE-RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
Query: 873 ARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
L+K + S+ + ++ L+EQ++ E K + + D++ A L S V +
Sbjct: 666 HELEKMQQSVYVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKA-LKSEVQKLQTL 720
Query: 930 DAEVEKNKRLMKTIEE-LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E + NK +++ +E+ ++ K + LK ++ + + K++E A R E E+
Sbjct: 721 VSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 779
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVA---LEKQIE 1044
++LK + + E K E+ ++K + LE + K++N++ L+++I+
Sbjct: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 839
Query: 1045 SLSNTPVSNSTMYVATGSAIVQN-QQITDVMK-ENQKLKKMNAKLITICKKRGKTG 1098
+L + N + A +I Q++ +++K + +++ M A L K TG
Sbjct: 840 ALKE-EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 894
Score = 60.9 bits (141), Expect = 2e-08
Identities = 177/858 (20%), Positives = 342/858 (39%), Gaps = 69/858 (8%)
Query: 39 ETQSNPIKLQDS--GTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ 96
E QS KL D+ + ++ Q ++ +N K E L ++ DI EQ AL+ + Q
Sbjct: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN-KEESLQMQVQDILEQNEALKAQIQ 586
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN---L 153
+ + + L KDK+IK DSL ++ ++ +EE + N L
Sbjct: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
Query: 154 IMENVTESDNLNKE----VDDLKKNNECLTQKCIDL----EKLVNESENKIGP-KNICAQ 204
+ V + L E +L+K + + K + E+L +E NK+ K + Q
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
K ++ +Q L +K + + K+ T++ L+ G E+
Sbjct: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELN 766
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFET---KAVKVMSEIKRNLNSLSEQLINNESKK- 320
+I+ DL K + F + + KV+ E + S+ E+L+ E K
Sbjct: 767 AIRTE-NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV-EELLEAELLKV 824
Query: 321 -SKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL----EKYTKVQG 375
+K+ + + L E G L+ + L +I +K Q +L +L E+ ++
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL--SITSKVQ-ELQNLLKGKEEQMNTMKA 881
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA-----VTIDIVKKE 430
L E +L + + L L + + ++ + + + E SSA + I + +KE
Sbjct: 882 VLEEKEKDLANTGKWLQDLQEE--NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 939
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKL 490
NELK + + LK + + L QD+ K LF + I Q L + +Y+ +
Sbjct: 940 NELKRL--EAMLKERESDLSSKTQLLQDVQDENK---LFKSQIEQ--LKQQNYQ-QASSF 991
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
K + ++ L+ + V+ ++ L + + A +
Sbjct: 992 PPHEELLKVI----SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1047
Query: 551 KILSEEIDALKIAIAKNEEKM-LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK 609
K+L ++++ + E + L E KL VS + L + L+ + K
Sbjct: 1048 KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYG----EWLHGFEKKAK 1103
Query: 610 ETQA-SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ-NLA 667
E A + +V++ E D+M + + + + +EQ
Sbjct: 1104 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1163
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAE---IQNRMIMRLQKQIQEDDKLFIEK-ETKLNE 723
K + +E + +++ + + E+ E +N+ I L+++ +E ++ +EK E + +
Sbjct: 1164 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE-REHLEMELEKAEMERST 1222
Query: 724 LTNKYEALKRDYDAAVKDLESS-REAVNQLTTQKDLVEGRIAELESDIRTEQ-----TAT 777
+ LK K L+ S EAV Q + +L++ ++ E + +RTEQ A
Sbjct: 1223 YVTEVRELKDLLTELQKKLDDSYSEAVRQ-NEELNLLKAQLNETLTKLRTEQNERQKVAG 1281
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
T EN D+ +P+ + S K ++SV + V+QL++ L
Sbjct: 1282 DLHKAQQSLELIQSKIVKAAGDTTVIENSDV--SPETESSEKETMSVSLNQTVTQLQQLL 1339
Query: 838 LSCQQELDDLKERYKELD 855
+ Q+L KE Y+ L+
Sbjct: 1340 QAVNQQLTKEKEHYQVLE 1357
Score = 43.6 bits (98), Expect = 0.004
Identities = 56/276 (20%), Positives = 123/276 (44%), Gaps = 16/276 (5%)
Query: 814 LDDSPKRSISVISDSEVSQLKER---LLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ D+ K+S + + QL+E+ L + +++ K+R K+L E T E +
Sbjct: 315 IQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE---RSNV 371
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRT--QQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
R+K +LE++ + + +I Q+ + Q KF V + + A+L + +
Sbjct: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQE--NGIL 429
Query: 929 YDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
DA +L K EL +QD V ++ + K +++ + + + K +
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
Query: 988 LEELKQRYKELDE--ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L+E ++R++E+ T Q++ Q K + + + KL++ V+ ++Q+E
Sbjct: 490 LQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-KQQLEQ 548
Query: 1046 LSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK 1081
+ + V ++ Q+ D++++N+ LK
Sbjct: 549 RLMQLMESEQKRVNKEESL--QMQVQDILEQNEALK 582
Score = 43.6 bits (98), Expect = 0.004
Identities = 129/600 (21%), Positives = 238/600 (39%), Gaps = 62/600 (10%)
Query: 516 DTLEEAHNEVKSLHE-ELTKL---YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
D + N+++S EL KL Y V+E K+ EE+ A + K+
Sbjct: 431 DAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTG--KLQQEEVQKKNAEQAATQLKV 488
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKS--LNDVITREKETQASELERSCQVIKQNGFE 629
L E + + E+ S I E+ + + + + +E E Q+ + + ++ + E
Sbjct: 489 -QLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLE 547
Query: 630 LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH 689
M+ LM + + +LEQN ALK Q ++ +I +T
Sbjct: 548 QRLMQ---LMESEQKRVNKEESLQM--QVQDILEQNEALKAQIQQ-----FHSQIAAQTS 597
Query: 690 EKT-AEIQNRMIMRLQKQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
AE +++I KQI Q +D L E++ LT+K E LK D L++ +
Sbjct: 598 ASVLAEELHKVIAEKDKQIKQTEDSLASERD----RLTSKEEELK-DIQNMNFLLKAEVQ 652
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ L ++ ELE + +Q+ V F N
Sbjct: 653 KLQALANEQ---AAAAHELE---KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN-- 704
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE 867
+N L ++ +++S+ + E++ C QE D E+ K +++ ET +
Sbjct: 705 -DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD---EKLKTVEELLETGLIQVAT 760
Query: 868 RDEQCARLKKEKLSLEQQVSNLK----EQIRTQQPVERQAKFA---DVAVNTDEDW---- 916
++E+ ++ E SL ++V +LK +Q+ VE K D + + E+
Sbjct: 761 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 917 ----ANLHSVVVD-RMSYDAEVEK--NKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYT 968
AN V D + A E+ N +L K + + K Q+L+N + ++ M
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880
Query: 969 ----KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
+K+K+ K L+D + E E LK +E+ + A Q EE LKE +
Sbjct: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940
Query: 1025 ALEIVDKLSNQKVA-LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
L+ ++ + ++ + L + + L + N QN Q +++L K+
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000
Score = 32.3 bits (70), Expect = 9.9
Identities = 33/153 (21%), Positives = 64/153 (41%), Gaps = 7/153 (4%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK 85
+ +G K +E + N K++ + S K + ++ S +LE+L E DI+
Sbjct: 1145 ETEGILQKLQRSVEQEENKWKVK----VDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 86 EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
+ E L R +++++ E+++L + + K L DS ++ EL
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVR--ELKDLLTELQ-KKLDDSYSEAVRQNEELNL 1257
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
L+ + + TE + K DL K + L
Sbjct: 1258 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1290
>AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 87.4 bits (207), Expect = 2e-16
Identities = 188/953 (19%), Positives = 383/953 (40%), Gaps = 88/953 (9%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ SL+ + +K +K T S + + + E ++ + L N E+ L++++D
Sbjct: 499 SQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD 558
Query: 170 DLKKNNECLT-----QKCIDL-----EKLVNESENKIGPKNICAQCKLKENLIQSL---- 215
+ N+ +K +DL +KL+NE + K+ + K++E + Q
Sbjct: 559 KTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL-----TLEFKIREEVTQEFTQYW 613
Query: 216 ---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL 272
+ TL + R I + N R L + D E K++C + K E
Sbjct: 614 AQREADFKETLLQ-EREILEENAERRLAIFKDLVGKCDTREEAAKDIC----ATKVETEE 668
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE--QLINNESKKSKDHIDRYKD 330
+ + ++ E + + + +K E+K+ N Q + +KK R K+
Sbjct: 669 ATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKE 728
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L+ ++D + ++ IN++Q +L +E K + TS L +N K
Sbjct: 729 -LINIIDQK-------------EDTINEFQ-NLKSHMENTFKCNDKAD--TSSL-IINNK 770
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-ELKEILTKECLKLSKLKI 449
L + + K++ I +++R++E KK + + +T++ K +++
Sbjct: 771 LICNETVEVPKDSKSKICS-ERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRP 829
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
+I D + + L + EL ++EK L K +
Sbjct: 830 NIAEIEDIRVLQENNEGLRAFLLTIENELKNE----KEEKAELN----KQIVHFQQELSL 881
Query: 510 XXXXXFDTLEEAHNEVKSLHE-ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
TL + +++S ++ + +L+ K ++K LS EI+ +I N
Sbjct: 882 SEKKNL-TLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMK-LSNEIETATRSITNNV 939
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
++ + K ++L L S + N L +L D+ +E + + N +
Sbjct: 940 SQIKLMHTKIDELRTLDSVS---QISNIDLLNLRDLSNGSEEDNLPNTQLD---LLGNDY 993
Query: 629 ELDK-MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
+ K +K + +E K +++ + Q EE + +L+ +K
Sbjct: 994 LVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVK 1053
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
++ + NR+ +K+ + D L EKET + +L + + D ++ + +
Sbjct: 1054 GYK---DENNRL---KEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKR 1107
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
A+++LT + +I ELE+ + T++ +
Sbjct: 1108 ALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEH 1167
Query: 808 LGENPK-LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD-DECETCAEYL 865
L ++ K D + + + E++QL L + L LKE +E + E E E L
Sbjct: 1168 LQDSVKNTKDLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKEEEEETNRQETEKLKEEL 1224
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD 925
+ LK + E+ ++LKE++ + +Q + +V+V DED L + ++
Sbjct: 1225 SASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEVSVMRDED--KLLRIKIN 1281
Query: 926 RMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELED 983
+ + MK TI++L K+ L N K+++A+++Y + K+ K K +ED
Sbjct: 1282 ELEKKKNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQYERACKDLNVKEKIIED 1336
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LEE +Q E D+ E E +++ + ++ KE LE + + K
Sbjct: 1337 MRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNK 1389
Score = 71.7 bits (168), Expect = 1e-11
Identities = 180/947 (19%), Positives = 379/947 (40%), Gaps = 71/947 (7%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEM 117
C LK N+I +L K GEL KE+ E + +LI LET + ++ + E+
Sbjct: 672 CLELK--FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL 729
Query: 118 ENLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
N+ KE N +LK+ + + ++ DT S+LI+ N N EV K+
Sbjct: 730 INIIDQKEDTINEFQNLKSHMENTFKCNDKADT-SSLIINNKLIC-NETVEVPKDSKSKI 787
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
C +K ++ E + + E +I + E+ +S + + + R + ++N
Sbjct: 788 CSERKRVN-ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 846
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE-PNMTMDLDEKLGENNEFETKA 295
R + T+++EL +E+ EL + + L L E N+T+ + + ++N ++
Sbjct: 847 LR-AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN-YDIAI 904
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDN 354
++ ++++ N E+ I K + I+ S+ V + T +D L D+
Sbjct: 905 AEL--HVQKSKNQEQEEKI----MKLSNEIETATRSITNNVSQIKLMHTKIDELRTL-DS 957
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSV-NEKLAS--LNSQLIEKENACNILRIQ 411
+ IDL + + + D N ++L + N+ L S + I++ N N
Sbjct: 958 VSQISNIDLLNLRDLSNGSEED-NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1016
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
E I E + KK ++++E+ ++ KL+ ++ D++ +K D
Sbjct: 1017 IEAIWEECKEIVKASSKKSHQIEELEQ----QIEKLQAEVKGYKDENNRLKEKEHKNQDD 1072
Query: 472 LITQYE--LSRTDYEIEKEKLRLETG-----TAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
L+ + E + + E++++ + L+ K LE
Sbjct: 1073 LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 1132
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
K KL + +++ + L L + L E + L+ ++ KN + L+ K+ KL E
Sbjct: 1133 QKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV-KNTK---DLNVKELKLKEE 1188
Query: 585 VSTI-NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
++ + N L++ +K L + E+ET E E+ + + + +KAD+
Sbjct: 1189 ITQLTNNLQD----MKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1244
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
+ K + ++ ++++ + + LE + +++ R I +L
Sbjct: 1245 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1304
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
++Q+ K+ E +YE +D + K +E R + + Q + + ++
Sbjct: 1305 KEQLNNQ---------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQV 1354
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E + + E+ AT + LG+ L D + S
Sbjct: 1355 LEAKLE-EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQ 1413
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
+ L+E+++ Q + R KE+ +Y ++R+ R K++ +E
Sbjct: 1414 KYNADRKKWLEEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEME 1462
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ L E+ +++ + D V E L +++ + D E+E+ KR++
Sbjct: 1463 ILTAQLTEK---DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISET 1517
Query: 944 EELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ + D+K ++ + FE R ++ED L+
Sbjct: 1518 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 1564
Score = 61.3 bits (142), Expect = 2e-08
Identities = 199/1023 (19%), Positives = 412/1023 (40%), Gaps = 98/1023 (9%)
Query: 117 MENLTKDKE-IKNLTDSLKTKSKKINELQEEND-TLS-NLIMENVTESDNLNKEVDDLKK 173
+E+L +D++ ++ L ++ +T++ + L E+ D TL N + E L ++DLKK
Sbjct: 526 LEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKK 585
Query: 174 NNECLTQKCIDLE-KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL---NRS 229
++ + LE K+ E + + KE L+Q I +N +L
Sbjct: 586 KLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDL 645
Query: 230 ISDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN 288
+ +T K IC + E + C EL F IK L + + +E
Sbjct: 646 VGKCDTREEAAKDICATKVETEEATA-CLEL--KFNQIKAELAKTKGELIKTKEELKKRE 702
Query: 289 NEFETKAVKVMSEIKRNL--NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-L 345
NE ++ ++ + K+ + N ++LIN +K +D I+ +++ L + ++ F
Sbjct: 703 NESDSLIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQN-LKSHMENTFKCNDKA 760
Query: 346 DVFEILMDN--IINK-YQIDLD---EILEKYTKV-QGDLNECTSELK--SVNEKLASLNS 396
D ++++N I N+ ++ D +I + +V + +L + K S++ A
Sbjct: 761 DTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITED 820
Query: 397 QLIEKENACNILRIQKERI-HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
Q +E NI I+ R+ E + + ++ ENELK +E +L+K + ++L
Sbjct: 821 QKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNE-KEEKAELNKQIVHFQQEL 879
Query: 456 D----QDLPAHKKITIL---FDALITQYELSRTDYEIEKEK---LRLETGTAKAVXXXXX 505
++L K++ + +D I + + ++ + ++EK L E TA
Sbjct: 880 SLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNV 939
Query: 506 XXXXXXXXXFDTLE--EAHNEVKSLHE-ELTKLYKSKVDEN--NANLNLIK---ILSEEI 557
D L ++ +++ ++ L L ++N N L+L+ ++S+++
Sbjct: 940 SQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQV 999
Query: 558 DALKIAIAKNEEKMLSLSEKD-NKLTELVSTINGLKEENNSLKSLNDVITREKETQASEL 616
+I E S E + E+V + + L+ + + E + E
Sbjct: 1000 KEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDEN 1059
Query: 617 ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT 676
R + +N +L K K ++ + + ++E AL E + T
Sbjct: 1060 NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV--QIQHVVEGKRALSELTQGVT 1117
Query: 677 RDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE-ALKRD 734
C + +I ++T +T +++ +L++ I E + + ++ E L E + ++K
Sbjct: 1118 --CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
Query: 735 YDAAVKDLESSREAV---NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
D VK+L+ E N L K L++ + E E++ + +
Sbjct: 1176 KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 1235
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE------VSQLKERLLSCQQELD 845
+ D L + K ++ +SV+ D + +++L+++ C QELD
Sbjct: 1236 ADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 1295
Query: 846 DLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ------- 896
+ ++L ++ + E +Q+ + C L ++ +E L+EQ +TQ
Sbjct: 1296 MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVL 1355
Query: 897 ----QPVERQA--------KFADVAVNTDEDWANLHSVVVDRMS---------YDAEVEK 935
+ VER A K D+ ++ H D + ++E +
Sbjct: 1356 EAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKY 1415
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
N K +EE K K M+KY + + F ++ E+E A+L E
Sbjct: 1416 NADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDL 1475
Query: 996 KELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQIESLSNTPV 1051
++ EE + L E Q K L + + +E + ++ ++ +E QI + +
Sbjct: 1476 QKWREERDQLVAAL---EIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1532
Query: 1052 SNS 1054
S++
Sbjct: 1533 SSA 1535
Score = 39.1 bits (87), Expect = 0.086
Identities = 62/284 (21%), Positives = 114/284 (40%), Gaps = 32/284 (11%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKEL--DDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
E ++ +LL ++LD E K +E + +++ ++ KKEKL+LE ++
Sbjct: 544 ETQNVETKLLD--EDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKI 601
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEE 945
Q TQ +R+A F + +++ +R + E+ + K + +
Sbjct: 602 REEVTQEFTQYWAQREADFKE-------------TLLQEREILEENAERRLAIFKDLVGK 648
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL----EELKQRYKELDEE 1001
+++ K+ + E + +F + EL K EL EELK+R E D
Sbjct: 649 CDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSL 708
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
+ K+ Q +R+KE + I+D+ + + + NT N T
Sbjct: 709 IQELETSNKKIITQNQRIKE---LINIIDQKEDTINEFQNLKSHMENTFKCNDK--ADTS 763
Query: 1062 SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENED 1105
S I+ N+ I + E K K IC +R + N +D
Sbjct: 764 SLIINNKLICNETVEVPKDSKSK-----ICSERKRVNENELQQD 802
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 1361 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 1418
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 1419 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1478
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 1479 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1532
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 1533 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 1586
>AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 87.4 bits (207), Expect = 2e-16
Identities = 188/953 (19%), Positives = 383/953 (40%), Gaps = 88/953 (9%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ SL+ + +K +K T S + + + E ++ + L N E+ L++++D
Sbjct: 499 SQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLD 558
Query: 170 DLKKNNECLT-----QKCIDL-----EKLVNESENKIGPKNICAQCKLKENLIQSL---- 215
+ N+ +K +DL +KL+NE + K+ + K++E + Q
Sbjct: 559 KTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL-----TLEFKIREEVTQEFTQYW 613
Query: 216 ---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL 272
+ TL + R I + N R L + D E K++C + K E
Sbjct: 614 AQREADFKETLLQ-EREILEENAERRLAIFKDLVGKCDTREEAAKDIC----ATKVETEE 668
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE--QLINNESKKSKDHIDRYKD 330
+ + ++ E + + + +K E+K+ N Q + +KK R K+
Sbjct: 669 ATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKE 728
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L+ ++D + ++ IN++Q +L +E K + TS L +N K
Sbjct: 729 -LINIIDQK-------------EDTINEFQ-NLKSHMENTFKCNDKAD--TSSL-IINNK 770
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-ELKEILTKECLKLSKLKI 449
L + + K++ I +++R++E KK + + +T++ K +++
Sbjct: 771 LICNETVEVPKDSKSKICS-ERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRP 829
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
+I D + + L + EL ++EK L K +
Sbjct: 830 NIAEIEDIRVLQENNEGLRAFLLTIENELKNE----KEEKAELN----KQIVHFQQELSL 881
Query: 510 XXXXXFDTLEEAHNEVKSLHE-ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
TL + +++S ++ + +L+ K ++K LS EI+ +I N
Sbjct: 882 SEKKNL-TLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMK-LSNEIETATRSITNNV 939
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
++ + K ++L L S + N L +L D+ +E + + N +
Sbjct: 940 SQIKLMHTKIDELRTLDSVS---QISNIDLLNLRDLSNGSEEDNLPNTQLD---LLGNDY 993
Query: 629 ELDK-MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
+ K +K + +E K +++ + Q EE + +L+ +K
Sbjct: 994 LVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVK 1053
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
++ + NR+ +K+ + D L EKET + +L + + D ++ + +
Sbjct: 1054 GYK---DENNRL---KEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKR 1107
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
A+++LT + +I ELE+ + T++ +
Sbjct: 1108 ALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEH 1167
Query: 808 LGENPK-LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD-DECETCAEYL 865
L ++ K D + + + E++QL L + L LKE +E + E E E L
Sbjct: 1168 LQDSVKNTKDLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKEEEEETNRQETEKLKEEL 1224
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD 925
+ LK + E+ ++LKE++ + +Q + +V+V DED L + ++
Sbjct: 1225 SASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEVSVMRDED--KLLRIKIN 1281
Query: 926 RMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELED 983
+ + MK TI++L K+ L N K+++A+++Y + K+ K K +ED
Sbjct: 1282 ELEKKKNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQYERACKDLNVKEKIIED 1336
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ LEE +Q E D+ E E +++ + ++ KE LE + + K
Sbjct: 1337 MRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNK 1389
Score = 71.7 bits (168), Expect = 1e-11
Identities = 180/947 (19%), Positives = 379/947 (40%), Gaps = 71/947 (7%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEM 117
C LK N+I +L K GEL KE+ E + +LI LET + ++ + E+
Sbjct: 672 CLELK--FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKEL 729
Query: 118 ENLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
N+ KE N +LK+ + + ++ DT S+LI+ N N EV K+
Sbjct: 730 INIIDQKEDTINEFQNLKSHMENTFKCNDKADT-SSLIINNKLIC-NETVEVPKDSKSKI 787
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
C +K ++ E + + E +I + E+ +S + + + R + ++N
Sbjct: 788 CSERKRVN-ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 846
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE-PNMTMDLDEKLGENNEFETKA 295
R + T+++EL +E+ EL + + L L E N+T+ + + ++N ++
Sbjct: 847 LR-AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN-YDIAI 904
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDN 354
++ ++++ N E+ I K + I+ S+ V + T +D L D+
Sbjct: 905 AEL--HVQKSKNQEQEEKI----MKLSNEIETATRSITNNVSQIKLMHTKIDELRTL-DS 957
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSV-NEKLAS--LNSQLIEKENACNILRIQ 411
+ IDL + + + D N ++L + N+ L S + I++ N N
Sbjct: 958 VSQISNIDLLNLRDLSNGSEED-NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 1016
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
E I E + KK ++++E+ ++ KL+ ++ D++ +K D
Sbjct: 1017 IEAIWEECKEIVKASSKKSHQIEELEQ----QIEKLQAEVKGYKDENNRLKEKEHKNQDD 1072
Query: 472 LITQYE--LSRTDYEIEKEKLRLETG-----TAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
L+ + E + + E++++ + L+ K LE
Sbjct: 1073 LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 1132
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
K KL + +++ + L L + L E + L+ ++ KN + L+ K+ KL E
Sbjct: 1133 QKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV-KNTK---DLNVKELKLKEE 1188
Query: 585 VSTI-NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
++ + N L++ +K L + E+ET E E+ + + + +KAD+
Sbjct: 1189 ITQLTNNLQD----MKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1244
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
+ K + ++ ++++ + + LE + +++ R I +L
Sbjct: 1245 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1304
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
++Q+ K+ E +YE +D + K +E R + + Q + + ++
Sbjct: 1305 KEQLNNQ---------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQV 1354
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E + + E+ AT + LG+ L D + S
Sbjct: 1355 LEAKLE-EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQ 1413
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
+ L+E+++ Q + R KE+ +Y ++R+ R K++ +E
Sbjct: 1414 KYNADRKKWLEEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEME 1462
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ L E+ +++ + D V E L +++ + D E+E+ KR++
Sbjct: 1463 ILTAQLTEK---DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISET 1517
Query: 944 EELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ + D+K ++ + FE R ++ED L+
Sbjct: 1518 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 1564
Score = 61.3 bits (142), Expect = 2e-08
Identities = 199/1023 (19%), Positives = 412/1023 (40%), Gaps = 98/1023 (9%)
Query: 117 MENLTKDKE-IKNLTDSLKTKSKKINELQEEND-TLS-NLIMENVTESDNLNKEVDDLKK 173
+E+L +D++ ++ L ++ +T++ + L E+ D TL N + E L ++DLKK
Sbjct: 526 LEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKK 585
Query: 174 NNECLTQKCIDLE-KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL---NRS 229
++ + LE K+ E + + KE L+Q I +N +L
Sbjct: 586 KLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDL 645
Query: 230 ISDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN 288
+ +T K IC + E + C EL F IK L + + +E
Sbjct: 646 VGKCDTREEAAKDICATKVETEEATA-CLEL--KFNQIKAELAKTKGELIKTKEELKKRE 702
Query: 289 NEFETKAVKVMSEIKRNL--NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-L 345
NE ++ ++ + K+ + N ++LIN +K +D I+ +++ L + ++ F
Sbjct: 703 NESDSLIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQN-LKSHMENTFKCNDKA 760
Query: 346 DVFEILMDN--IINK-YQIDLD---EILEKYTKV-QGDLNECTSELK--SVNEKLASLNS 396
D ++++N I N+ ++ D +I + +V + +L + K S++ A
Sbjct: 761 DTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITED 820
Query: 397 QLIEKENACNILRIQKERI-HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
Q +E NI I+ R+ E + + ++ ENELK +E +L+K + ++L
Sbjct: 821 QKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNE-KEEKAELNKQIVHFQQEL 879
Query: 456 D----QDLPAHKKITIL---FDALITQYELSRTDYEIEKEK---LRLETGTAKAVXXXXX 505
++L K++ + +D I + + ++ + ++EK L E TA
Sbjct: 880 SLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNV 939
Query: 506 XXXXXXXXXFDTLE--EAHNEVKSLHE-ELTKLYKSKVDEN--NANLNLIK---ILSEEI 557
D L ++ +++ ++ L L ++N N L+L+ ++S+++
Sbjct: 940 SQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQV 999
Query: 558 DALKIAIAKNEEKMLSLSEKD-NKLTELVSTINGLKEENNSLKSLNDVITREKETQASEL 616
+I E S E + E+V + + L+ + + E + E
Sbjct: 1000 KEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDEN 1059
Query: 617 ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT 676
R + +N +L K K ++ + + ++E AL E + T
Sbjct: 1060 NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV--QIQHVVEGKRALSELTQGVT 1117
Query: 677 RDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE-ALKRD 734
C + +I ++T +T +++ +L++ I E + + ++ E L E + ++K
Sbjct: 1118 --CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 1175
Query: 735 YDAAVKDLESSREAV---NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
D VK+L+ E N L K L++ + E E++ + +
Sbjct: 1176 KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 1235
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE------VSQLKERLLSCQQELD 845
+ D L + K ++ +SV+ D + +++L+++ C QELD
Sbjct: 1236 ADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 1295
Query: 846 DLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ------- 896
+ ++L ++ + E +Q+ + C L ++ +E L+EQ +TQ
Sbjct: 1296 MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVL 1355
Query: 897 ----QPVERQA--------KFADVAVNTDEDWANLHSVVVDRMS---------YDAEVEK 935
+ VER A K D+ ++ H D + ++E +
Sbjct: 1356 EAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKY 1415
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
N K +EE K K M+KY + + F ++ E+E A+L E
Sbjct: 1416 NADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDL 1475
Query: 996 KELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQIESLSNTPV 1051
++ EE + L E Q K L + + +E + ++ ++ +E QI + +
Sbjct: 1476 QKWREERDQLVAAL---EIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1532
Query: 1052 SNS 1054
S++
Sbjct: 1533 SSA 1535
Score = 39.1 bits (87), Expect = 0.086
Identities = 62/284 (21%), Positives = 114/284 (40%), Gaps = 32/284 (11%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKEL--DDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
E ++ +LL ++LD E K +E + +++ ++ KKEKL+LE ++
Sbjct: 544 ETQNVETKLLD--EDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKI 601
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEE 945
Q TQ +R+A F + +++ +R + E+ + K + +
Sbjct: 602 REEVTQEFTQYWAQREADFKE-------------TLLQEREILEENAERRLAIFKDLVGK 648
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL----EELKQRYKELDEE 1001
+++ K+ + E + +F + EL K EL EELK+R E D
Sbjct: 649 CDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSL 708
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
+ K+ Q +R+KE + I+D+ + + + NT N T
Sbjct: 709 IQELETSNKKIITQNQRIKE---LINIIDQKEDTINEFQNLKSHMENTFKCNDK--ADTS 763
Query: 1062 SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENED 1105
S I+ N+ I + E K K IC +R + N +D
Sbjct: 764 SLIINNKLICNETVEVPKDSKSK-----ICSERKRVNENELQQD 802
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 1361 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 1418
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 1419 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 1478
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 1479 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 1532
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 1533 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 1586
>U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein.
Length = 2083
Score = 87.0 bits (206), Expect = 3e-16
Identities = 205/1051 (19%), Positives = 442/1051 (42%), Gaps = 102/1051 (9%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLM---SQIKSLEMENL 120
+E ++ + LEK E I ++K E LE Q + +L ++++ L+ E
Sbjct: 360 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE-LELQKKAILTESENKLRDLQQEAE 418
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT- 179
T I L SL+ KS + NE Q + D +L E + + V+ K E L
Sbjct: 419 TYRTRILELESSLE-KSLQENENQSK-DLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 476
Query: 180 -QKCIDLEKL-VNESENKIGPKNICAQCKL-KENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q + E+L V + + + + + +C+ KE L++ I + + ++N +
Sbjct: 477 QQDALWAEELQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK-LD 535
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN------- 289
++ +L SEL + +L E+ + +K+ + + + +DE+ +
Sbjct: 536 VNQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 595
Query: 290 -EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
E E + +K +N L E L+ K K+H + ++L A + G L
Sbjct: 596 KEHEVSIQRTEKALKDQINQL-ELLLKERDKHLKEH-QAHVENLEADIKRSEG--ELQQA 651
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNI 407
+D + YQ E + Y + L + +L++ L +++ +K++ C
Sbjct: 652 SAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 710
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L K ++ ++ + +K+N E K ++ + K++ D +++ K+I +
Sbjct: 711 LDAHKIQVQDLMQQL-----EKQNSEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILV 762
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
+ +I Q E +K+++ + T A F E+ +VK
Sbjct: 763 EKENMILQMR------EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 816
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE----KMLSLSEKDNK-LT 582
+E+ + K K+ + A L +E++ + +++ E+ KML +++ ++ ++
Sbjct: 817 KAKEMQETLKKKLLDQEAKLK------KELENTALELSQKEKQFNAKMLEMAQANSAGIS 870
Query: 583 ELVSTIN-GLKEENNSL-----KSLNDVIT---REKETQASELERSCQV-IKQNGFELDK 632
+ VS + KE+ SL + LNDVI+ ++ QA EL+ ++ +++ E+ +
Sbjct: 871 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAE 930
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL---EINIKTH 689
+K IL+ +E L+EQ ++K+ + L E +K H
Sbjct: 931 LKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAH 990
Query: 690 EKTAEIQ-NRMIMR---LQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAA 738
+ E+ N+ + LQ+Q+ E L E + K++ELT+K +++LK ++ +
Sbjct: 991 LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKS 1050
Query: 739 VKDLESS----REAVNQLTTQKD--------LVEGRIAELESDIRTEQTATVXXXXXXXX 786
K LE ++ +L Q D L+E + EL +I + +T +
Sbjct: 1051 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL-INISSSKTNAILSRISHCQ 1109
Query: 787 XXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE-RLLSCQQELD 845
T + ++ +IS + + KE ++ S + +++
Sbjct: 1110 HRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE 1169
Query: 846 DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ----PVER 901
L + L E + E++ +LKKE V+ +KE+++ ++ + +
Sbjct: 1170 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSK 1229
Query: 902 QAKFADVAVNTDEDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDL-KNTVTK 959
Q +V + + + + R YD E+ L+ +++L +K L K ++
Sbjct: 1230 QLTDLNVQLQNSISLSEKEAAISSLRKQYD---EEKCELLDQVQDLSFKVDTLSKEKISA 1286
Query: 960 MQKA---MEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQREEQ 1015
+++ K+++ K+ +++ + ++ EL+ +L+ + KE E+ E ++ ++Q
Sbjct: 1287 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1346
Query: 1016 CKRLKEAKIALE-IVDKLSNQKVALEKQIES 1045
KR K +E K+ ++ LE +++S
Sbjct: 1347 NKRFDCLKGEMEDDKSKMEKKESNLETELKS 1377
Score = 76.2 bits (179), Expect = 6e-13
Identities = 208/1084 (19%), Positives = 430/1084 (39%), Gaps = 80/1084 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-----LETQTRDLLMSQIKSL 115
Q + EI + +KLS + I E K++N ++ + +++ + K L
Sbjct: 770 QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 829
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKIN-ELQEENDTLSNLIMENVTESDNLNKE-VDDLKK 173
+ KE++N L K K+ N ++ E S I + V+ + KE ++ L +
Sbjct: 830 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 889
Query: 174 NNECLTQKCIDL-EKLVNESENKIGPKNICAQCKLKENLIQSLH---IGYDNTLSKLNRS 229
+ I + EK +N+ ++ + Q + KE + L + + ++N+
Sbjct: 890 VHRRELNDVISIWEKKLNQQAEELQEIHEI-QLQEKEQEVAELKQKILLFGCEKEEMNKE 948
Query: 230 IS--DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE 287
I+ + + LQ +L L +D T +K HLE + +DL++ L E
Sbjct: 949 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE----KLEVDLNKSLKE 1004
Query: 288 NNEFETKAVKVM---SEIKRNLNSLSEQL-INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
N + + V++ E KR ++ L+ +L +E +S + L EF
Sbjct: 1005 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1064
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGD-LNECTSELKSVNEKLASLNSQLIEKE 402
S ++ I +D K + L+ + + N S + + + L+ K
Sbjct: 1065 SEEL-AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1123
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
+ L Q ++ E + + I + ++L+E KE ++ +K DI L + A
Sbjct: 1124 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEE---KEN-QIKSMKADI-ESLVTEKEAL 1178
Query: 463 KKITILFDALITQYELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
+K ++ E T + E E + T + + D +
Sbjct: 1179 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1238
Query: 522 HNEVKSLHEE--LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD- 578
N + +E ++ L K +E L+ ++ LS ++D L ++EK+ +L + D
Sbjct: 1239 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL------SKEKISALEQVDD 1292
Query: 579 --NKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
NK +E + N++K L + K +A E + ++K+ + +K +
Sbjct: 1293 WSNKFSEWKKKAQSRFTQHQNTVKELQ-IQLELKSKEAYEKDEQINLLKEELDQQNK-RF 1350
Query: 636 DILMXXXXXXXXXXXXXXXX--DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
D L E KS + + L++ +KT + L +K + +
Sbjct: 1351 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1410
Query: 694 EIQNR-MIMRLQ--KQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+I+++ ++ +LQ +++ +E D E E K+ L N+ ++K + + K+LE +V
Sbjct: 1411 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV 1470
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF--GDENRD 807
+ +E R+ E ES + + + G E+
Sbjct: 1471 KSKEEELKALEDRL-ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1529
Query: 808 LGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
N KL + +R + ++ + V + L + ++ ++ + + + C +
Sbjct: 1530 SELNTKLQER-EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1588
Query: 866 -QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS--V 922
+E+ R EK L Q+V KE+ + E + ++ + + + A H
Sbjct: 1589 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH-FEMRCQYQERLIKLEHAEAKQHEDQS 1647
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYK---------KQDLKNTVTKMQKAMEKYTKKDKE 973
++ + + E EKNK+ + + K KQ+L+N +QK +++ +
Sbjct: 1648 MIGHLQEELE-EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1706
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
E K KEL+ C L K+ ++ EE + E L+ ++ R K ++ E ++ S
Sbjct: 1707 LEQKIKELDSC---LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1763
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ----QITDVMKENQKLKKMNAKLIT 1089
+ Q + LSN ++ + A + Q +I + K+ + L+K + + +
Sbjct: 1764 KSHLV---QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1820
Query: 1090 ICKK 1093
I KK
Sbjct: 1821 ILKK 1824
Score = 59.3 bits (137), Expect = 8e-08
Identities = 109/490 (22%), Positives = 209/490 (42%), Gaps = 40/490 (8%)
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT-ELVSTINGLKEENNSL 598
V E+ A++ ++ L + + + + + +E + S E+ LT E + L E L
Sbjct: 126 VVEDGASVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL 185
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL-MXXXXXXXXXXXXXXXXDE 657
+ + D+ EK ++L + +I+Q + + A+
Sbjct: 186 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 245
Query: 658 AKSLLEQNLALKEQCEEKTRDC-SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
K + Q L+EQ E+ R LE + T +KT E + ++ + +QI+ +K E
Sbjct: 246 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 305
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+ L + ++ +K++ +K +SS E + +L QK L E +A E ++ T++
Sbjct: 306 ERISLQQELSR---VKQEVVDVMK--KSSEEQIAKL--QK-LHEKELARKEQEL-TKKLQ 356
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
T + ++ E+ L++ + +++++SE +
Sbjct: 357 TREREFQEQMKVALEKSQSEYLKI--SQEKEQQESLALEELELQKKAILTESE-----NK 409
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
L QQE + + R EL+ E + LQE + Q L + LE + + ++I T
Sbjct: 410 LRDLQQEAETYRTRILELESSLE---KSLQENENQSKDLA---VHLEAEKNKHNKEI-TV 462
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+ + + + D WA V+ + Y E+EK + K +E K+ LK+
Sbjct: 463 MVEKHKTELESLKHQQDALWAEELQVL--KQQYQTEMEKLRE--KCEQE---KETLLKDK 515
Query: 957 VTKMQKAMEKYTKKDKE-FEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREE 1014
Q +E+ +K E + + ELE +EL E LK R+K L+EE LK + +
Sbjct: 516 EIIFQAHIEEMNEKTLEKLDVNQTELESLSSELSEVLKARHK-LEEELSV----LKDQTD 570
Query: 1015 QCKRLKEAKI 1024
+ K+ EAK+
Sbjct: 571 KMKQELEAKM 580
Score = 54.0 bits (124), Expect = 3e-06
Identities = 145/824 (17%), Positives = 326/824 (39%), Gaps = 54/824 (6%)
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
++ + K+++ ++E++ L +Q ++ D KD ++VL + +
Sbjct: 34 SQSQDKSLRKIAELREELQM--DQQAKKHLQEEFDASLEEKDQHISVLQTQVSLLKQRLR 91
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS-VNEKLASLNSQLIEKENACNI 407
M+ + K L+ E +TK + ++ ++ + K Q ++++ N+
Sbjct: 92 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGASVKTLETLQQRVKRQE--NL 149
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L+ KE I T+ +KE L+E L + +L K+K DL K IT
Sbjct: 150 LKRCKETIQSHKEQCTLLTSEKE-ALQEQLDERLQELEKIK-----DLHM-AEKTKLITQ 202
Query: 468 LFDA--LITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
L DA LI Q E + E ++ ET K + + E+
Sbjct: 203 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 262
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
++ EEL K + A L + E+I ++ +EE+ +SL ++ +++ +
Sbjct: 263 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE---KTSEEERISLQQELSRVKQ 319
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
V + K + L + +E + EL + Q ++ F+ ++MK +
Sbjct: 320 EVVDVMK-KSSEEQIAKLQKLHEKELARKEQELTKKLQT-REREFQ-EQMKVALEKSQSE 376
Query: 644 XXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
A LE Q A+ + E K RD + +T + E+++ +
Sbjct: 377 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT--RILELESSLEKS 434
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV--NQLTTQKDLVE 760
LQ+ + L + E + N+ + + + ++ L+ ++A+ +L K +
Sbjct: 435 LQENENQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWAEELQVLKQQYQ 494
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
+ +L E+ + + N E ++ +
Sbjct: 495 TEMEKLREKCEQEKETLLKDKEIIFQAHIE------------EMNEKTLEKLDVNQTELE 542
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR--LKKE 878
S+S SE+S++ + ++EL LK++ ++ E E + + +Q +K+
Sbjct: 543 SLS----SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH 598
Query: 879 KLSLEQQVSNLKEQIRTQQPV--ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN 936
++S+++ LK+QI + + ER + + + A++ + A+++
Sbjct: 599 EVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVF 658
Query: 937 KRLMKTIEELR--YKKQ--DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ E Y++Q L+ + ++ TK+ E EA++K++ C EL+ K
Sbjct: 659 QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV--C-TELDAHK 715
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
+ ++L ++ E ++Q+ + ++ E+K+ ++ +++ +EK+ L
Sbjct: 716 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 775
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+ + T + I + +E + K K + K++ K
Sbjct: 776 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 819
Score = 49.6 bits (113), Expect = 6e-05
Identities = 158/775 (20%), Positives = 312/775 (40%), Gaps = 70/775 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINL--KLEKLSGELFD 83
QL S+N N + +K + ++S ++ + N I+L K +S
Sbjct: 1198 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1257
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK--EIKNLTDSLKTKSKK-I 140
E+K L + Q+L + T L +I +LE + +K E K S T+ + +
Sbjct: 1258 YDEEKCELLDQVQDLSFKVDT--LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1315
Query: 141 NELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-- 198
ELQ + + S E + + L +E+D K +CL + D + + + E+ +
Sbjct: 1316 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1375
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKE 258
K+ A+ E+ I I ++ L+++ ++ + + LQ + G E
Sbjct: 1376 KSQTARIMELEDHITQKTIEIES-LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1434
Query: 259 LCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ E I LE +M +L+ K E E + V S+ + L +L ++L +ES
Sbjct: 1435 VKEAEEKILT-LENQVYSMKAELETK---KKELEHVNLSVKSK-EEELKALEDRL-ESES 1488
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLN 378
+ R + +A + + L E + + L E+ K + + +++
Sbjct: 1489 AAKLAELKRKAEQKIAAIKKQL----LSQMEEKEEQYKKGTESHLSELNTKLQEREREVH 1544
Query: 379 ECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILT 438
+LKSV +S + LI +A N+ ++ + V +K + L+ LT
Sbjct: 1545 ILEEKLKSVE---SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1601
Query: 439 KECLKLSKLKID----IPRDLDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKL 490
++ L ++ + + + +++ L A Q+E + E+E++
Sbjct: 1602 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1661
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV-KSLHE-ELT-KLYKSKVDENNANL 547
+ A+ V LE ++V K+L E ELT ++ + K+ E ++ L
Sbjct: 1662 KYSLIVAQHVEKEGGKNNIQAK---QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1718
Query: 548 NLIKILSEEIDALKIA-IAKNEEKMLSLSEKD--NKLTELVSTINGLKEENNSLKSLNDV 604
+ +E+ +++ + EK+ +L + D NK TEL+ EE + +
Sbjct: 1719 ----VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT---EEKSKSHLVQPK 1771
Query: 605 ITREKETQASELE---RSCQVIKQN-GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ E Q ++LE + KQ G E+ +++ D+ M D+ +
Sbjct: 1772 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1831
Query: 661 L----------LEQNLALKEQCEEKTRDCSR----LEINIK-THEKTAEIQNRMIMRLQK 705
L+ N LK+ E ++ LE+ IK T K E++ ++ Q+
Sbjct: 1832 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE 1891
Query: 706 QIQEDDKLFIEKETKLNELTNKYE----ALKRDYDAAVKDLESSREAVNQLTTQK 756
+ + K EK+ L +YE A + + A V+DL++ E + + QK
Sbjct: 1892 ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 1946
Score = 41.9 bits (94), Expect = 0.012
Identities = 121/616 (19%), Positives = 257/616 (41%), Gaps = 50/616 (8%)
Query: 24 RNQLDGAKSKNDNIIETQSNPI-KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
+++++ +S + +++Q+ I +L+D IT +SL E N + + EL
Sbjct: 1361 KSKMEKKESNLETELKSQTARIMELEDH--ITQKTIEIESLNEVLKNYNQQKDIEHKELV 1418
Query: 83 DIKEQKSALEGKYQNLILETQTRDL-LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKIN 141
+ L + N + E + + L L +Q+ S++ E TK KE++++ S+K+K +++
Sbjct: 1419 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1478
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
L++ ++ S + + +++ +KK + L+Q E+ +E+ + N
Sbjct: 1479 ALEDRLESESAAKLAELKR--KAEQKIAAIKK--QLLSQMEEKEEQYKKGTESHLSELN- 1533
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGREDCKELC 260
KL+E + +HI + L + S S++ R K + + +A + C +
Sbjct: 1534 ---TKLQER-EREVHI-LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ-- 1586
Query: 261 EDFTSIKNHLELHEPNMT--MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ + + + + N+T L +++G+ E ET V S + E+LI E
Sbjct: 1587 ---KTYEEKISVLQRNLTEKEKLLQRVGQEKE-ET----VSSHFEMRC-QYQERLIKLEH 1637
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII---NKYQIDLDEILEK-YTKVQ 374
++K H D+ S++ L E + I+ ++ K I + LE + VQ
Sbjct: 1638 AEAKQHEDQ---SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1694
Query: 375 GDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI-HEISSAVTIDIVKKENEL 433
L E + + +K+ L+S L+ ++ + R++ E + + + + N+
Sbjct: 1695 KTLQEKELTCQILEQKIKELDSCLVRQK---EVHRVEMEELTSKYEKLQALQQMDGRNKP 1751
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI-LFDALITQYELSRTDYEIEKEKLRL 492
E+L + + SK + P+ L H + L A + +L + ++K+ L
Sbjct: 1752 TELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1811
Query: 493 ETGTAKAVXXXXXXXXXXXXXXF----DTLEEAHNE-VKSLHEELTKLYKSKVDENNANL 547
+ + + LE HN +K L E K E +
Sbjct: 1812 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTI 1871
Query: 548 NLIKILSEEIDALKIAIAKNEEKML--SLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
++E++A + + E L ++EKD+ +L T +E ++ +
Sbjct: 1872 KETINKAQEVEAELLESHQEETNQLLKKIAEKDD---DLKRTAKRYEEILDAREEEMTAK 1928
Query: 606 TREKETQASELERSCQ 621
R+ +TQ EL++ Q
Sbjct: 1929 VRDLQTQLEELQKKYQ 1944
>U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein.
Length = 3113
Score = 87.0 bits (206), Expect = 3e-16
Identities = 207/1024 (20%), Positives = 438/1024 (42%), Gaps = 112/1024 (10%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
+ EL I+ +K+++E ++ L LE +++ ++ LE +N K K I L + L
Sbjct: 1899 VENELSRIRSEKASIE--HEALYLEADL-EVVQTEKLCLEKDNENKQKVIVCLEEELSVV 1955
Query: 137 SKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
+ + N+L+ E DT+S + T D L++++ + + E +C+ + +E ++
Sbjct: 1956 TSERNQLRGELDTMS----KKTTALDQLSEKMKEKTQELESHQSECL---HCIQVAEAEV 2008
Query: 197 GPKNICAQCKLKENLIQSLHIGYDNT-LSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
K Q L ++ + L D T L + +S+ + + K C L++++ ++
Sbjct: 2009 KEKTELLQ-TLSSDVSELLK---DKTHLQEKLQSLEKDSQALSLTK-CELENQIAQLNKE 2063
Query: 256 CKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEF------------------ETK 294
+ L ++ S++ L + + N++ L+ L E EF E
Sbjct: 2064 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2123
Query: 295 AVKVMSEIKRNLN---SLSEQLINNESKKSK-DHIDR-----YKDSLLAVLDAEFGTTSL 345
V++ ++ K+ L+ L E+ N+S K K ++++R ++ L +LDAE +
Sbjct: 2124 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2183
Query: 346 DVFEILMDNI---INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + ++ + + +++DL + + + + E +L +++ L+S S L EKE
Sbjct: 2184 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2243
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEIL--TKECLKLSKLKIDIPRDLDQDL- 459
A IQ + + + + + +K+ NE L +E +K ++ +D P + + L
Sbjct: 2244 QA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2299
Query: 460 PAHKKITILFDA-----LITQYELSRTDYEIEKEKLRLET--GTAKAVXXXXXXXXXXXX 512
+ +K+ +A L +L +++ + K R+E +
Sbjct: 2300 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE 2359
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKI------- 562
+E +++ + + L L V + NL L +E I L+I
Sbjct: 2360 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFEN 2419
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL-ND-VITREKETQASELERSC 620
+ + E++ + + EK + E++ T LKE N + +L ND + KE S
Sbjct: 2420 ILQEKEQEKVQMKEKSSTAMEMLQT--QLKELNERVAALHNDQEACKAKEQNLSSQVECL 2477
Query: 621 QVIKQNGFE-LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ K + LD+ K + ++ + + E+ LK Q +++ +
Sbjct: 2478 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2537
Query: 680 SRLEINIKTH----EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
S+L H E+ E++N + + L+++IQ + L L + Y+ L+ +
Sbjct: 2538 SKLSQVEGEHQLWKEQNLELRN-LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2596
Query: 736 DAAVKDLESSREAVNQLTT-----QKDLVE--GRIAELESDIRTEQTATVXXXXXXXXXX 788
+ D S E VN++T Q+++ E + AEL+ ++ E+
Sbjct: 2597 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2656
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD--SEVSQLKERLLSCQQELDD 846
EN +L ++ LD K + E+++ + RL +++
Sbjct: 2657 KSSKDQLKELTL---ENSELKKS--LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2711
Query: 847 -LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
L + K+ + E +T E L + E+C L +KL ++ S+ KE++ ++ +
Sbjct: 2712 LLLDTNKQYEVEIQTYREKLTSK-EEC--LSSQKLEIDLLKSS-KEELNNS--LKATTQI 2765
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
+ T D NL V + + K K L+K+ ++L +K+ L+ ++++Q A E
Sbjct: 2766 LEELKKTKMD--NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2823
Query: 966 KY---TKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K T D + + E+++ K LEE K+ + LD+ C + ++ E+ K + E
Sbjct: 2824 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH--EKLEKAKEMLE 2881
Query: 1022 AKIA 1025
++A
Sbjct: 2882 TQVA 2885
Score = 75.8 bits (178), Expect = 8e-13
Identities = 206/989 (20%), Positives = 415/989 (41%), Gaps = 99/989 (10%)
Query: 65 ESSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
E NE K + L EL + +++ L G+ + +T D L ++K E +
Sbjct: 1935 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1994
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT-QKC 182
E + + + K+ EL + TLS+ + E + + +L +++ L+K+++ L+ KC
Sbjct: 1995 SECLHCIQVAEAEVKEKTELLQ---TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2051
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
E EN+I N + +KE+ + ++ KLN +S + + K
Sbjct: 2052 --------ELENQIAQLNKEKELLVKESESLQARLS-ESDYEKLN--VSKALEAALVEK- 2099
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEP---NMTMDLDEKLGENNEFETKAVKVM 299
L + +E+ +L ++ +E E ++ L E+ EN+ + K +
Sbjct: 2100 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2159
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
E++ ++ +++L+ +++ SK ++ K + E SL VFE+ + + ++
Sbjct: 2160 RELQ--MSEENQELVILDAENSKAEVETLKTQI------EEMARSLKVFELDLVTLRSEK 2211
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK-ENACNILRIQKERIHEI 418
+ +I EK ++ +L++ S KS+ E+ Q+ E+ + A +L+ Q + ++E
Sbjct: 2212 ENLTKQIQEKQGQLS-ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2270
Query: 419 SSAVTID--IVKK-ENELKEILTKECL---KLSKLKIDIPRDLDQDLPAHKKITIL---F 469
+A+ D I+K E L + +E + KL+ + D + L +++
Sbjct: 2271 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2330
Query: 470 DALITQYELSRTDYEIEK---EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
D L + E + EI + E LE +K LE ++
Sbjct: 2331 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2390
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
S E LT + K E + L +I E I + + E++ + + EK + E++
Sbjct: 2391 SEKENLTNELQ-KEQERISELEIINSSFENI------LQEKEQEKVQMKEKSSTAMEMLQ 2443
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
T LKE N + +L++ ++ +A E S QV EL+K A +L
Sbjct: 2444 T--QLKELNERVAALHN---DQEACKAKEQNLSSQV---ECLELEK--AQLLQGLDEAKN 2493
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+ L+++ K++ E+K + SRL+ I+ E+ ++ +L Q
Sbjct: 2494 NYIVLQSSVN---GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-------LVSKLS-Q 2542
Query: 707 IQEDDKLFIEKETKLNELTNKYEA---LKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
++ + +L+ E+ +L LT + E + + +A+++D LE + + L + +L +
Sbjct: 2543 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT--K 2600
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI 822
+ ++ + + G++NR GE L + K S
Sbjct: 2601 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2660
Query: 823 SVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
+ + E S+LK+ L C + D E+ ++ +E AEY E A K + L
Sbjct: 2661 DQLKELTLENSELKKSL-DCMHK--DQVEKEGKVREEI---AEYQLRLHE--AEKKHQAL 2712
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN--KR 938
L+ +N + ++ Q E+ + + E+ + + +D + E N K
Sbjct: 2713 LLD---TNKQYEVEIQTYREK--------LTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2761
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ +EEL+ K D V +++K E+ K K K+LE+ K L++ + +
Sbjct: 2762 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2821
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALE 1027
E+ +T + +E +KE K LE
Sbjct: 2822 QEKQKTGTVMDTKVDELTTEIKELKETLE 2850
Score = 72.1 bits (169), Expect = 1e-11
Identities = 209/1010 (20%), Positives = 378/1010 (37%), Gaps = 69/1010 (6%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ L L K +E++ D LK K+ + Q + D+L + + +N E +LK
Sbjct: 10 EGLPTRALQKIQELEGQLDKLK---KEKQQRQFQLDSLEAAPQKQTQKVENEKTEGTNLK 66
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ N+ L + C LEK + +++ K +Q +E + S + +L R S+
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKE--SQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
S + QS D C + FT+ + + + DL EK N E E
Sbjct: 125 LERSQQ-----AAQS-ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY--NKEVE 176
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE--- 349
+ ++ +E+K + Q + + +D S + E + L
Sbjct: 177 ERK-RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT 235
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLIEKENACN 406
+ + Y E+ + +Q D N + S L L +Q E N N
Sbjct: 236 PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 407 ILRI-----QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
L + +KE +++ + + + E E++ KE + L+K + ++ R Q A
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQL-QLEKAKVELIEKEKV-LNKCRDELVRTTAQYDQA 353
Query: 462 HKKITILFDAL--ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
K T L L +T+ +LS E + LE K F TL+
Sbjct: 354 STKYTALEQKLKKLTE-DLSCQRQNAESARCSLEQ-KIKEKEKEFQEELSRQQRSFQTLD 411
Query: 520 EAHNEVKS-LHEEL--TKLYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLS 575
+ ++K+ L +EL K + + L +K L ++ K + + E+ +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K+N EL ++ +K+ENN LKS ++ RE +EL+ Q + Q+ ++MKA
Sbjct: 472 IKEN---ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA 528
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ SL + L L EK RDCS + +K E E
Sbjct: 529 ---KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS--QDLLKKREHHIEQ 583
Query: 696 QNRMIMRLQKQIQE--DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE----AV 749
N + + +K+ + +KE +L E + K + + + +ES +E +
Sbjct: 584 LNDKLSKTEKESKALLSALELKKKEYELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 643
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
N L T + + E +RT + T +L
Sbjct: 644 NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQ 703
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC--ETCAEYLQE 867
+ + D + + SQL ++ + +L L + D C + AEY
Sbjct: 704 QKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD-KDRCYQDLHAEYESL 762
Query: 868 RDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
RD LK + SL + + + Q FA++ + + S R+
Sbjct: 763 RD----LLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI-IGEQGSMPSERSEC--RL 815
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC-KA 986
D + + L ++ L + + K + +QK E+ + E E + E ++
Sbjct: 816 EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQS 875
Query: 987 ELEELKQRYKELDEEC----ETCAEYLKQREEQCKRLK--EAKIALE--IVDKLSNQKVA 1038
+ E QR +L E+ AE L E + K L+ K+ E + +L
Sbjct: 876 FVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHL 935
Query: 1039 LEKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKL 1087
LE ++ L + S S I N ++I ++ +EN LK++NA L
Sbjct: 936 LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 985
Score = 72.1 bits (169), Expect = 1e-11
Identities = 184/941 (19%), Positives = 371/941 (39%), Gaps = 74/941 (7%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKE 167
L ++K ENL I++ +++ ++ EL + +M + L K
Sbjct: 1771 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI 1830
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYD-NTLSKL 226
V +LKK N L++K LE + + + + + E L L + D ++ +
Sbjct: 1831 VGELKKENSDLSEK---LEYFSCDHQ------ELLQRVETSEGLNSDLEMHADKSSREDI 1881
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++ N S + + +++EL R + + + ++ LE+ + L
Sbjct: 1882 GDNVAKVNDSWK-ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-----LE 1935
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
++NE + K + + E + S QL ++ SKK+ +D+ + + + T
Sbjct: 1936 KDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT-TALDQLSEKM------KEKTQ 1988
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
L+ + + I + ++ E E + D++E + + EKL SL +
Sbjct: 1989 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE----KDSQ 2044
Query: 404 ACNILRIQKE-RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
A ++ + + E +I +++ + +VK+ L+ L++ + K+++ + L+ L
Sbjct: 2045 ALSLTKCELENQIAQLNKEKEL-LVKESESLQARLSESDYE----KLNVSKALEAALVEK 2099
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEE 520
+ + + TQ E+ + IEK ++R+E K + D +E
Sbjct: 2100 GEFALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2157
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
E++ + EE +L + + A + +K EE+ A + + + + L SEK+N
Sbjct: 2158 LERELQ-MSEENQELVILDAENSKAEVETLKTQIEEM-ARSLKVFELDLVTLR-SEKENL 2214
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREK--ETQASELERSCQVIKQNGF-ELDKMKADI 637
++ L E + L S ++ ++ E Q E ++ + QN EL++ A +
Sbjct: 2215 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2274
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLE--QNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+E L + L + + +EK + C + +K E A++
Sbjct: 2275 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADL 2332
Query: 696 QNRMIMRLQKQIQ----EDDKLFIEKETKLNE---LTNKYEALKRDYDAAVKDLESSREA 748
+ L+++++ + +E E E L K E + + D+ + R
Sbjct: 2333 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2392
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
LT + + RI+ELE + + T E +
Sbjct: 2393 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2452
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
D ++ S+V L+ Q LD+ K Y L +QE
Sbjct: 2453 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN---GLIQEV 2509
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVD-R 926
++ +L+K+ ++++S LK QI+ Q Q V + ++ E L ++ V+
Sbjct: 2510 EDGKQKLEKK----DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2565
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKN--TVTKMQK-----AMEKYTKKDKEFEAKRK 979
KN L T+E L+ ++L+N +TKM K + K T K+ E + +
Sbjct: 2566 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2625
Query: 980 ELEDCKAEL-EELKQRYKELDEECETCAEYLKQREEQCKRL 1019
E+ AEL EEL L E + E +K ++Q K L
Sbjct: 2626 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2666
Score = 68.9 bits (161), Expect = 9e-11
Identities = 193/1031 (18%), Positives = 417/1031 (40%), Gaps = 97/1031 (9%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNL----TDSLKTKSKK 139
IKE++ + + QT D Q+K+ + L + K + N+ D L + ++
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
Query: 140 I-NELQEENDTL---SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ N L+E L + + + L + ++++KK N L + V E +
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 196 IGPKNICAQCKLKENLIQSL---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ KNI +N + + + + L L I+ S K+ ++L+
Sbjct: 509 L--KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQ 566
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
R DC + + ++H+E L++KL + E E+KA+ E+K+ L E+
Sbjct: 567 R-DCSQ--DLLKKREHHIE--------QLNDKLSK-TEKESKALLSALELKKKEYELKEE 614
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK 372
KS++ + LL +++E + ++ + QI E E+
Sbjct: 615 KTLFSCWKSEN------EKLLTQMESEKENLQSKINH--LETCLKTQQIKSHEYNERVRT 666
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE---RIH--EI------SSA 421
++ D + E+++++ L S + ++ ++ A L+ + E + H EI +S
Sbjct: 667 LEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQ 726
Query: 422 VTIDIVKKENELK----EILTKE-CLKLSKLKIDIPRDLDQDLPA-------HKKITILF 469
+T + E++L+ EI+ K+ C + + + RDL + A H++ + F
Sbjct: 727 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAF 786
Query: 470 DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH 529
D + S + E+ + E + D+LE + K ++
Sbjct: 787 DQQPAMHH-SFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 845
Query: 530 EELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS-T 587
+L K + V + NL+K +E++ + +A+ +++ L E + +V+ T
Sbjct: 846 SDLQKQCEELVQIKGEIEENLMK--AEQMH--QSFVAETSQRISKLQEDTSAHQNVVAET 901
Query: 588 INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
++ L+ + L+ LND + E + + EL++S +++ + EL + + +
Sbjct: 902 LSALENKEKELQLLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI 960
Query: 648 XXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQI 707
E + L ++N LKE ++ L ++ + + + I L Q
Sbjct: 961 ISLNKR---EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1017
Query: 708 QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
+++ + ++ + E N YE L + Y AA + +N+ T+ L E R ELE
Sbjct: 1018 KQEKLILLQ---RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS---LCENRKNELE 1071
Query: 768 SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+ E ++ D+ S
Sbjct: 1072 -----QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN-----SK 1121
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL--SLEQQ 885
SE LK+ +++ ++E + +++ +L E E + ++ + E C L+ E + S++++
Sbjct: 1122 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE-CQNLESEPIRNSVKER 1180
Query: 886 VSNLKEQIRTQQPVERQAKFADVAVNT-DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
S + Q + ++ + K ++++++ + L +++ ++ E EK K ++
Sbjct: 1181 ESE-RNQCNFKPQMDLEVK--EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ--H 1235
Query: 945 ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
EL+ + DL+ + + ++ E KD E +A+ K + EL + L +T
Sbjct: 1236 ELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG-PHELSTSQNDNAHLQCSLQT 1294
Query: 1005 CAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGS 1062
L + E+ C+ L+ K L E+ D S A K E + + N + S
Sbjct: 1295 TMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK--LLNEVKILNDDS 1352
Query: 1063 AIVQNQQITDV 1073
++ + + D+
Sbjct: 1353 GLLHGELVEDI 1363
Score = 68.1 bits (159), Expect = 2e-10
Identities = 195/1019 (19%), Positives = 405/1019 (39%), Gaps = 93/1019 (9%)
Query: 31 KSKNDNII-ETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKS 89
KS+N+ ++ + +S LQ +C Q +K S+E N ++ L + ++ +
Sbjct: 622 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIR 679
Query: 90 ALEGKYQNLILETQTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKKINELQEEND 148
L + +E +T+ L +++ E + KEI+N+ + ++ +L+ +
Sbjct: 680 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 739
Query: 149 TLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLK 208
LSN IM+ +L+ E + L+ + L K L + + + A
Sbjct: 740 LLSNEIMDKDRCYQDLHAEYESLR---DLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF 796
Query: 209 ENLI-QSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE---DCKELCEDFT 264
N+I + + + + +L S N++ N++ +L+ L++ ++ D ++ CE+
Sbjct: 797 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 856
Query: 265 SIKNHLE--------LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE--QLI 314
IK +E +H+ + + +++ + E + V++E L + + QL+
Sbjct: 857 QIKGEIEENLMKAEQMHQ-SFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 915
Query: 315 NNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQ 374
N++ + + I K S + D SL ++L + ++ + ++ I+ +
Sbjct: 916 NDKVETEQAEIQELKKSNHLLED------SLKELQLLSET-LSLEKKEMSSIISLNKREI 968
Query: 375 GDLNECTSELKSVNEKLASLNSQLIEK-ENACNILRIQKERIHEISSAVTIDIVKKENEL 433
+L + LK +N L LI+K E+ N + +++ I E+S D K+E
Sbjct: 969 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELS-----DQYKQE--- 1020
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
K IL + C + D+ + + K+ L + + E + + E KE E
Sbjct: 1021 KLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKE 1080
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
+T+++A L E+T D N + + L
Sbjct: 1081 HQEFLTKLAFAEERNQNLMLELETVQQA------LRSEMT-------DNQNNSKSEAGGL 1127
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS---LNDVITREKE 610
+EI LK K ++++ L +++ +L +++ T K E +L+S N V RE E
Sbjct: 1128 KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKT----KHECQNLESEPIRNSVKERESE 1183
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ ++ LD A ++ E + L + ++
Sbjct: 1184 RNQCNFKPQMD-LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1242
Query: 671 QCE-EKTRDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-----KETKLNE 723
E +D EI+ +K E AE + + + ++D ++ KLNE
Sbjct: 1243 DLETSNLQDMQSQEISGLKDCEIDAE-EKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE 1301
Query: 724 LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXX 783
L E L+ + V +L SR +T + + E + +L ++++ +
Sbjct: 1302 LEKICEILQAEKYELVTELNDSRSEC--ITATRKMAE-EVGKLLNEVK-----ILNDDSG 1353
Query: 784 XXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV----SQLKERLLS 839
+E + P LD+S +SD EV ++L+E+ LS
Sbjct: 1354 LLHGELVEDIPGGEFGEQPNEQHPVSLAP-LDESNSYEHLTLSDKEVQMHFAELQEKFLS 1412
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLK-EQIRTQQP 898
Q E L +++ ++ + Y+ LK E L L + N + + ++ Q
Sbjct: 1413 LQSEHKILHDQHCQMSSKMSELQTYVDS-------LKAENLVLSTNLRNFQGDLVKEMQL 1465
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK--NKRLMKTIEELRYKKQDLKNT 956
+ ++ + D ++L S + D Y A +E+ + L+ +E Q +
Sbjct: 1466 GLEEGLVPSLSSSCVPDSSSLSS-LGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1524
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
V E T+K+ A K +E+ ++ E +Q ++L+E+ E+ +K +E Q
Sbjct: 1525 VFCSSLQEENLTRKETP-SAPAKGVEELESLCEVYRQSLEKLEEKMES-QGIMKNKEIQ 1581
Score = 67.7 bits (158), Expect = 2e-10
Identities = 177/964 (18%), Positives = 398/964 (41%), Gaps = 90/964 (9%)
Query: 55 ISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS 114
+S KM + +E + + L + ++KE+ L+ ++ + + L +++S
Sbjct: 1979 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS 2038
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD----- 169
LE ++ L + + +K+ L +E+++L + E+ E N++K ++
Sbjct: 2039 LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2098
Query: 170 ------DLKKNNECLTQKCIDLEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDN- 221
L E + Q +EKL V ++ +I + K +E SL +N
Sbjct: 2099 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENL 2158
Query: 222 ----TLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
+S+ N+ + + ++ TL+++++ K D ++++ E N+
Sbjct: 2159 ERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE----NL 2214
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
T + EK G+ +E + K++S K L EQ ++SK ++ ++ L + +
Sbjct: 2215 TKQIQEKQGQLSELD----KLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQLKELNE 2269
Query: 338 AEFGTTSLDVFEILMD-NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A V + D I+ + LD +E+ +++ + + + L++ +K +
Sbjct: 2270 A--------VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2321
Query: 397 QLIEKENACNILRIQKERI-HEISSAVTID---IVKKENELKEILTKECLKLSKLKIDIP 452
QL E E+ ++L+ + E + E+ A T ++ EN E+ T + K+ + +
Sbjct: 2322 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA-KIEGMTQSL- 2379
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
R L+ D+ +TI + EL + I + ++ + + +
Sbjct: 2380 RGLELDV-----VTIRSEKENLTNELQKEQERISELEI-INSSFENILQEKEQEKVQMKE 2433
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+E ++K L+E + L+ + N LS +++ L++ + + +
Sbjct: 2434 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN----LSSQVECLEL---EKAQLLQ 2486
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L E N L S++NGL +E K +K+ + S L+ Q +Q +L +
Sbjct: 2487 GLDEAKNNYIVLQSSVNGLIQEVEDGKQK----LEKKDEEISRLKNQIQDQEQLVSKLSQ 2542
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL--EINIKTHE 690
++ + + + + L +N +L++ E L E+ + +
Sbjct: 2543 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2602
Query: 691 KTAEIQ--NRMIMRLQKQIQEDDKLFIEKETKL-NELTNKYEALKRDYDAAVKDLESSRE 747
K + ++ N+M + + ++Q + +K +L EL+ + L + +++++SS++
Sbjct: 2603 KMSFVEKVNKMTAK-ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2661
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ +LT + ++ + + D + E+ V E
Sbjct: 2662 QLKELTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQLRL-------------HEAEK 2707
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAEYLQ 866
+ LD + + + + + E KE LS Q+ E+D LK +EL++ + + L+
Sbjct: 2708 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2767
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
E LKK K+ + V+ LK++ + + + K + E+ + + +
Sbjct: 2768 E-------LKKTKMDNLKYVNQLKKE---NERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2817
Query: 927 MSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
+ E +K +M T ++EL + ++LK T+ + K ++Y K ++LE K
Sbjct: 2818 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2877
Query: 986 AELE 989
LE
Sbjct: 2878 EMLE 2881
Score = 65.3 bits (152), Expect = 1e-09
Identities = 189/988 (19%), Positives = 411/988 (41%), Gaps = 109/988 (11%)
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+D LK N+ L K +LE + E ++ G N + +L+ + I + L+K
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ T+ +Y++ T + L+ + K+L ED + + + E ++ + EK
Sbjct: 340 RDELV--RTTAQYDQASTKYTALE---QKLKKLTEDLSCQRQNAESARCSLEQKIKEK-- 392
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
EF+ + +S +R+ +L ++ I +++ +++ + + K+ + VL AE L
Sbjct: 393 -EKEFQEE----LSRQQRSFQTLDQECIQMKARLTQE-LQQAKN-MHNVLQAELD--KLT 443
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLI---- 399
+ ++N + +++ L + + Q +L E+K N L S + Q
Sbjct: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 400 ----EKENACNILRIQKERIHEISSAVTI------DIVKKENELKEILTKECLKLSKLKI 449
E +N L + E+ + T D+ +K N+ + LT E LKL+ +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 450 DIPRDLDQDLPAHKK--ITILFD----------ALITQYELSRTDYEIEKEKLRLETGTA 497
+ RD QDL ++ I L D AL++ EL + +YE+++EK +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYELKEEKTLFSCWKS 623
Query: 498 K--AVXXXXXXXXXXXXXXFDTLEEA--HNEVKSLHEELTKLYKSKVDENNANL---NLI 550
+ + + LE ++KS HE ++ ++D N ++ NL
Sbjct: 624 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKS-HEYNERVRTLEMDRENLSVEIRNLH 682
Query: 551 KIL---SEEIDALKIAIAKNEEKMLSLSEKDNKLTELV----STINGLKEE-NNSLKSL- 601
+L S E++ K+A + ++K +K K E + S + G E+ + L+ L
Sbjct: 683 NVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 742
Query: 602 NDVITREKETQA--SELERSCQVIKQNGFEL--DKMKADILMXXXXXXXXXXXXXXXXDE 657
N+++ +++ Q +E E ++K L ++ L+ E
Sbjct: 743 NEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGE 802
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
S+ + + + ++ ++ + L+ + + E + E Q +M LQKQ +E ++ E
Sbjct: 803 QGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI 862
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK-DLVEGRIAELE---SDIRTE 773
E L + +++ + + L+ A + + +E + EL+ + TE
Sbjct: 863 EENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETE 922
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
Q T E +++ L+ KR I ++ E L
Sbjct: 923 QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN---KREIEELTQ-ENGTL 978
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQ---QV 886
KE S QE +L ++ E+ A Y+ ER++ + L K+EKL L Q +
Sbjct: 979 KEINASLNQEKMNLIQK-------SESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1031
Query: 887 SNLKEQI--RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
N E + + + E+ +K + +N ++++ +A ++++ + +
Sbjct: 1032 GNAYEDLSQKYKAAQEKNSKL-ECLLNECTSLCENRKNELEQLK-EAFAKEHQEFLTKLA 1089
Query: 945 ELRYKKQDLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
+ Q+L + +Q+A+ + E ++E+ K E ++++ +L
Sbjct: 1090 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1149
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-----NQKVALEKQIESLSNTPVSNS 1054
+E E + +K + E C+ L+ I + ++ S N K ++ +++ +S + +
Sbjct: 1150 QENEQLMKVMKTKHE-CQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS---LDSY 1205
Query: 1055 TMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ A+++N+++ ++E++K K+
Sbjct: 1206 NAQLVQLEAMLRNKELK--LQESEKEKE 1231
Score = 64.1 bits (149), Expect = 3e-09
Identities = 141/735 (19%), Positives = 299/735 (40%), Gaps = 54/735 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL----E 116
++LK E+ L+ +L ++ +K L + Q + D L+S KSL E
Sbjct: 2184 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2243
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINEL-------QEENDTLSNLIMENVTESDNLNKEVD 169
+ +E K + L+ + K++NE QE + + E L ++
Sbjct: 2244 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2303
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTL-SKLNR 228
L+ E +K + + + + ESE+ + ++ ENL + L I N + L
Sbjct: 2304 KLRARLEADEKKQLCVLQQLKESEHHAD----LLKGRV-ENLERELEIARTNQEHAALEA 2358
Query: 229 SISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGE 287
S T KI + L D + + ++ N L+ + ++ +++ E
Sbjct: 2359 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2418
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-LD 346
N E + KV + K +S + +++ + K+ + + + A E +S ++
Sbjct: 2419 NILQEKEQEKVQMKEK---SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2475
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE-------LKSVNEKLASLNSQLI 399
E+ ++ LDE Y +Q +N E L+ +E+++ L +Q+
Sbjct: 2476 CLELEKAQLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2531
Query: 400 EKENACNILRIQKERIHEISSAVTIDI----VKKENELKEILTKECLKLSKLKI--DIPR 453
++E + L Q E H++ +++ V+ E +++ + +K L++ +
Sbjct: 2532 DQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2590
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA-VXXXXXXXXXXXX 512
+L+ +L K + F + + T+ + E ++ +T + +
Sbjct: 2591 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2650
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ ++ + +++K L E ++L KS + + + EEI ++ + + E+K
Sbjct: 2651 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ 2710
Query: 573 SLSEKDNKLTEL-VSTINGL---KEENNSLKSLN-DVITREKETQASELERSCQVIKQNG 627
+L NK E+ + T KEE S + L D++ KE + L+ + Q+++
Sbjct: 2711 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE--- 2767
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
EL K K D L + K L++ L+E+ E ++ S+L+ +
Sbjct: 2768 -ELKKTKMDNLKYVNQLKKENERAQG---KMKLLIKSCKQLEEEKEILQKELSQLQA-AQ 2822
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+KT + + + L +I+E + EK + +E +KY +L ++ K E
Sbjct: 2823 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2882
Query: 748 AVNQLTTQKDLVEGR 762
V L +Q+ + R
Sbjct: 2883 QVAHLCSQQSKQDSR 2897
Score = 58.4 bits (135), Expect = 1e-07
Identities = 188/970 (19%), Positives = 386/970 (39%), Gaps = 75/970 (7%)
Query: 114 SLEMENLTKD-------KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
SL+ ENLT+ K ++ L + + + +L+E+ + S IM+N E L +
Sbjct: 1529 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME--SQGIMKN-KEIQELEQ 1585
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+ ++ +CL ++ + + + + K+ + + KL Q+ + + +++L
Sbjct: 1586 LLSSERQELDCLRKQYLSENE---QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1642
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ + S+R + + E C E + H+ + D D +
Sbjct: 1643 Q--LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQD 1700
Query: 287 ENNEFE----TKAVKVMSEI--KRNLNSLSEQLINNESKKSKDHIDRYKDS---LLAVLD 337
N + E T A+K E +++ ++ E ++++ S + I S L +D
Sbjct: 1701 LNLDIEKITETGALKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMD 1760
Query: 338 AEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ ++ + N+ L I ++ KV+ LNE +K ++ KL Q
Sbjct: 1761 FLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE----MKELDSKLHLQEVQ 1816
Query: 398 LIEKENAC----NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L+ K AC I+ K+ ++S + + L+ + T E L S L++ +
Sbjct: 1817 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN-SDLEMHADK 1875
Query: 454 DLDQDLPAH-KKITILFDA--LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXX 510
+D+ + K+ + L + ELSR I EK +E
Sbjct: 1876 SSREDIGDNVAKVNDSWKERFLDVENELSR----IRSEKASIEHEALYLEADLEVVQTEK 1931
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
D E + L EEL+ + E N + +S++ AL K +EK
Sbjct: 1932 LCLEKDN-ENKQKVIVCLEEELSVV----TSERNQLRGELDTMSKKTTALDQLSEKMKEK 1986
Query: 571 MLSLSEKDNKLTELVSTING-LKEENNSLKSLN-DV--ITREK---ETQASELERSCQVI 623
L ++ + +KE+ L++L+ DV + ++K + + LE+ Q +
Sbjct: 1987 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2046
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK-SLLEQNLALKEQCEEKTRDCSRL 682
EL+ A + E+ L + AL+ EK RL
Sbjct: 2047 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2106
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
T E+ +++ R I +L+ +I+ D+K + KL E + ++LK + ++L
Sbjct: 2107 S---STQEEVHQLR-RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2162
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ S E NQ D E AE+E+ ++T+ +
Sbjct: 2163 QMSEE--NQELVILD-AENSKAEVET-LKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 2218
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET- 860
++ L E KL S K + +E+ Q+KE + ++ L+ + KEL++
Sbjct: 2219 QEKQGQLSELDKLLSSFKSLLEEKEQAEI-QIKEE---SKTAVEMLQNQLKELNEAVAAL 2274
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VNTDEDWANL 919
C + QE + + + E Q+ N E++R + + + + + + E A+L
Sbjct: 2275 CGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL 2332
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
V+ + + E+ + + +E K +++ K++ + + + R
Sbjct: 2333 LKGRVENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2391
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-AKIALEIVDKLSNQKVA 1038
E E+ EL++ ++R EL+ + L+++E++ ++KE + A+E+ L Q
Sbjct: 2392 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM---LQTQLKE 2448
Query: 1039 LEKQIESLSN 1048
L +++ +L N
Sbjct: 2449 LNERVAALHN 2458
Score = 56.4 bits (130), Expect = 5e-07
Identities = 186/857 (21%), Positives = 341/857 (39%), Gaps = 91/857 (10%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-----I 302
EL D E E F+ +H EL + T + G N++ E A K E +
Sbjct: 1833 ELKKENSDLSEKLEYFSC--DHQELLQRVETSE-----GLNSDLEMHADKSSREDIGDNV 1885
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAV-LDAEFGTTSLDVFEILMDNIINKYQI 361
+ +S E+ ++ E++ S+ ++ A+ L+A+ + + DN NK ++
Sbjct: 1886 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE-NKQKV 1944
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEIS 419
+ + E+ + V + N+ EL ++++K +L+ QL EK E + Q E +H I
Sbjct: 1945 IVC-LEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEKTQELESHQSECLHCIQ 2002
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
A VK++ EL + L+ + +L K K + L Q L + L T+ EL
Sbjct: 2003 VAEAE--VKEKTELLQTLSSDVSELLKDKTHLQEKL-QSLEKDSQALSL-----TKCELE 2054
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
++ KEK L V ++ L N K+L L + +
Sbjct: 2055 NQIAQLNKEKELL-------VKESESLQARLSESDYEKL----NVSKALEAALVEKGEFA 2103
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+ ++ + + L I+ L++ I +E+K L ++EK + + EN+SLK
Sbjct: 2104 LRLSSTQEEVHQ-LRRGIEKLRVRIEADEKKQLHIAEK----------LKERERENDSLK 2152
Query: 600 SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK 659
+ V E+E Q SE + ++ + + KA++ +
Sbjct: 2153 --DKVENLERELQMSEENQELVIL-----DAENSKAEVETLKTQIEEMARSLKVFELDLV 2205
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-E 718
+L + L +Q +EK S L+ + + + E + + + QI+E+ K +E +
Sbjct: 2206 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA----EIQIKEESKTAVEMLQ 2261
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
+L EL AL D + +S + + ++ +E A LE+D + +Q +
Sbjct: 2262 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK-KQLCVL 2320
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
+ R E+ L+ S EV LK ++
Sbjct: 2321 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-------SKGEVETLKAKIE 2373
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
Q L L+ + E E LQ+ E+ + L+ S E + KEQ + Q
Sbjct: 2374 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE-KEQEKVQ-- 2430
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ ++ A + T N V +A K + L +E L +K L +
Sbjct: 2431 MKEKSSTAMEMLQTQLKELN-ERVAALHNDQEACKAKEQNLSSQVECLELEKAQL---LQ 2486
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
+ +A Y +E+ED K +LE+ DEE ++ +E+ +
Sbjct: 2487 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK-------KDEEISRLKNQIQDQEQLVSK 2539
Query: 1019 LK----EAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGS-AIVQNQ-QIT 1071
L E ++ E +L N V LE++I+ L + S T+ V S ++N+ ++T
Sbjct: 2540 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2599
Query: 1072 --DVMKENQKLKKMNAK 1086
D M +K+ KM AK
Sbjct: 2600 KMDKMSFVEKVNKMTAK 2616
Score = 47.2 bits (107), Expect = 3e-04
Identities = 60/290 (20%), Positives = 124/290 (42%), Gaps = 17/290 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSL---- 882
+ E+ L +++ + Q E+ +LK+ L+D + LQ E + KKE S+
Sbjct: 909 EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE----LQLLSETLSLEKKEMSSIISLN 964
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADV-AVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-- 939
++++ L ++ T + + + + E +AN +S ++ K ++L
Sbjct: 965 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1024
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
++ EE +DL K + A EK +K + E+ K ELE+LK+ + +
Sbjct: 1025 LQRCEETGNAYEDLSQ---KYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEH 1081
Query: 1000 EECETCAEYLKQREEQCK-RLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTM 1056
+E T + ++R + L+ + AL E+ D +N K + + + M
Sbjct: 1082 QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM 1141
Query: 1057 YVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDP 1106
+ +N+Q+ VMK + + + ++ I K ++ N+ N P
Sbjct: 1142 QKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKP 1191
>AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 87.0 bits (206), Expect = 3e-16
Identities = 207/1024 (20%), Positives = 438/1024 (42%), Gaps = 112/1024 (10%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
+ EL I+ +K+++E ++ L LE +++ ++ LE +N K K I L + L
Sbjct: 1900 VENELSRIRSEKASIE--HEALYLEADL-EVVQTEKLCLEKDNENKQKVIVCLEEELSVV 1956
Query: 137 SKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
+ + N+L+ E DT+S + T D L++++ + + E +C+ + +E ++
Sbjct: 1957 TSERNQLRGELDTMS----KKTTALDQLSEKMKEKTQELESHQSECL---HCIQVAEAEV 2009
Query: 197 GPKNICAQCKLKENLIQSLHIGYDNT-LSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
K Q L ++ + L D T L + +S+ + + K C L++++ ++
Sbjct: 2010 KEKTELLQ-TLSSDVSELLK---DKTHLQEKLQSLEKDSQALSLTK-CELENQIAQLNKE 2064
Query: 256 CKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEF------------------ETK 294
+ L ++ S++ L + + N++ L+ L E EF E
Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124
Query: 295 AVKVMSEIKRNLN---SLSEQLINNESKKSK-DHIDR-----YKDSLLAVLDAEFGTTSL 345
V++ ++ K+ L+ L E+ N+S K K ++++R ++ L +LDAE +
Sbjct: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 346 DVFEILMDNI---INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + ++ + + +++DL + + + + E +L +++ L+S S L EKE
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEIL--TKECLKLSKLKIDIPRDLDQDL- 459
A IQ + + + + + +K+ NE L +E +K ++ +D P + + L
Sbjct: 2245 QA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2300
Query: 460 PAHKKITILFDA-----LITQYELSRTDYEIEKEKLRLET--GTAKAVXXXXXXXXXXXX 512
+ +K+ +A L +L +++ + K R+E +
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE 2360
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKI------- 562
+E +++ + + L L V + NL L +E I L+I
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFEN 2420
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL-ND-VITREKETQASELERSC 620
+ + E++ + + EK + E++ T LKE N + +L ND + KE S
Sbjct: 2421 ILQEKEQEKVQMKEKSSTAMEMLQT--QLKELNERVAALHNDQEACKAKEQNLSSQVECL 2478
Query: 621 QVIKQNGFE-LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ K + LD+ K + ++ + + E+ LK Q +++ +
Sbjct: 2479 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2538
Query: 680 SRLEINIKTH----EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
S+L H E+ E++N + + L+++IQ + L L + Y+ L+ +
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRN-LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597
Query: 736 DAAVKDLESSREAVNQLTT-----QKDLVE--GRIAELESDIRTEQTATVXXXXXXXXXX 788
+ D S E VN++T Q+++ E + AEL+ ++ E+
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD--SEVSQLKERLLSCQQELDD 846
EN +L ++ LD K + E+++ + RL +++
Sbjct: 2658 KSSKDQLKELTL---ENSELKKS--LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2712
Query: 847 -LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
L + K+ + E +T E L + E+C L +KL ++ S+ KE++ ++ +
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSK-EEC--LSSQKLEIDLLKSS-KEELNNS--LKATTQI 2766
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
+ T D NL V + + K K L+K+ ++L +K+ L+ ++++Q A E
Sbjct: 2767 LEELKKTKMD--NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824
Query: 966 KY---TKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K T D + + E+++ K LEE K+ + LD+ C + ++ E+ K + E
Sbjct: 2825 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH--EKLEKAKEMLE 2882
Query: 1022 AKIA 1025
++A
Sbjct: 2883 TQVA 2886
Score = 77.4 bits (182), Expect = 3e-13
Identities = 213/1013 (21%), Positives = 386/1013 (38%), Gaps = 74/1013 (7%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ L L K +E++ D LK K+ + Q + D+L + + + +N E +LK
Sbjct: 10 EGLPTRALQKIQELEGQLDKLK---KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ N+ L + C LEK + +++ K +Q +E + S + +L R S+
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKE--SQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
S + QS D C + FT+ + + + DL EK N E E
Sbjct: 125 LERSQQ-----AAQS-ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY--NKEVE 176
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE--- 349
+ ++ +E+K + Q + + +D S + E + L
Sbjct: 177 ERK-RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT 235
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLIEKENACN 406
+ + Y E+ + +Q D N + S L L +Q E N N
Sbjct: 236 PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 407 ILRI-----QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
L + +KE +++ + + + E E++ KE + L+K + ++ R Q A
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQL-QLEKAKVELIEKEKV-LNKCRDELVRTTAQYDQA 353
Query: 462 HKKITILFDAL--ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
K T L L +T+ +LS E + LE K F TL+
Sbjct: 354 STKYTALEQKLKKLTE-DLSCQRQNAESARCSLEQ-KIKEKEKEFQEELSRQQRSFQTLD 411
Query: 520 EAHNEVKS-LHEEL--TKLYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLS 575
+ ++K+ L +EL K + + L +K L ++ K + + E+ +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K+N EL ++ +K+ENN LKS ++ RE +EL+ Q + Q+ ++MKA
Sbjct: 472 IKEN---ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA 528
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ SL + L L EK RDCS + +K E E
Sbjct: 529 ---KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS--QDLLKKREHHIEQ 583
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
N +L K +E L E K E YE LK + + + + Q+ ++
Sbjct: 584 LND---KLSKTEKESKALLSALELKKKE----YEELKEEKTLFSCWKSENEKLLTQMESE 636
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG---DENRDLGENP 812
K+ ++ +I LE+ ++T+Q + D E
Sbjct: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
Query: 813 KLDDSPKRSISVISDSE-VSQLKERLLSCQQ---ELDDLKERYKELDDEC---ETCAEYL 865
KL + + SD + +++ L Q +++DL+ + + L +E + C + L
Sbjct: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
Query: 866 QERDEQCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
E L K K SL + + + Q FA++ + + S
Sbjct: 757 HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI-IGEQGSMPSERSEC- 814
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
R+ D + + L ++ L + + K + +QK E+ + E E + E
Sbjct: 815 -RLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 985 -KAELEELKQRYKELDEEC----ETCAEYLKQREEQCKRLK--EAKIALE--IVDKLSNQ 1035
++ + E QR +L E+ AE L E + K L+ K+ E + +L
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS 933
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKL 1087
LE ++ L + S S I N ++I ++ +EN LK++NA L
Sbjct: 934 NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
Score = 75.8 bits (178), Expect = 8e-13
Identities = 206/989 (20%), Positives = 415/989 (41%), Gaps = 99/989 (10%)
Query: 65 ESSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
E NE K + L EL + +++ L G+ + +T D L ++K E +
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT-QKC 182
E + + + K+ EL + TLS+ + E + + +L +++ L+K+++ L+ KC
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQ---TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2052
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
E EN+I N + +KE+ + ++ KLN +S + + K
Sbjct: 2053 --------ELENQIAQLNKEKELLVKESESLQARLS-ESDYEKLN--VSKALEAALVEK- 2100
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEP---NMTMDLDEKLGENNEFETKAVKVM 299
L + +E+ +L ++ +E E ++ L E+ EN+ + K +
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
E++ ++ +++L+ +++ SK ++ K + E SL VFE+ + + ++
Sbjct: 2161 RELQ--MSEENQELVILDAENSKAEVETLKTQI------EEMARSLKVFELDLVTLRSEK 2212
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK-ENACNILRIQKERIHEI 418
+ +I EK ++ +L++ S KS+ E+ Q+ E+ + A +L+ Q + ++E
Sbjct: 2213 ENLTKQIQEKQGQLS-ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2271
Query: 419 SSAVTID--IVKK-ENELKEILTKECL---KLSKLKIDIPRDLDQDLPAHKKITIL---F 469
+A+ D I+K E L + +E + KL+ + D + L +++
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 470 DALITQYELSRTDYEIEK---EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
D L + E + EI + E LE +K LE ++
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2391
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
S E LT + K E + L +I E I + + E++ + + EK + E++
Sbjct: 2392 SEKENLTNELQ-KEQERISELEIINSSFENI------LQEKEQEKVQMKEKSSTAMEMLQ 2444
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
T LKE N + +L++ ++ +A E S QV EL+K A +L
Sbjct: 2445 T--QLKELNERVAALHN---DQEACKAKEQNLSSQV---ECLELEK--AQLLQGLDEAKN 2494
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+ L+++ K++ E+K + SRL+ I+ E+ ++ +L Q
Sbjct: 2495 NYIVLQSSVN---GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-------LVSKLS-Q 2543
Query: 707 IQEDDKLFIEKETKLNELTNKYEA---LKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
++ + +L+ E+ +L LT + E + + +A+++D LE + + L + +L +
Sbjct: 2544 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT--K 2601
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI 822
+ ++ + + G++NR GE L + K S
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 823 SVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
+ + E S+LK+ L C + D E+ ++ +E AEY E A K + L
Sbjct: 2662 DQLKELTLENSELKKSL-DCMHK--DQVEKEGKVREEI---AEYQLRLHE--AEKKHQAL 2713
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN--KR 938
L+ +N + ++ Q E+ + + E+ + + +D + E N K
Sbjct: 2714 LLD---TNKQYEVEIQTYREK--------LTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ +EEL+ K D V +++K E+ K K K+LE+ K L++ + +
Sbjct: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2822
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALE 1027
E+ +T + +E +KE K LE
Sbjct: 2823 QEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Score = 72.1 bits (169), Expect = 1e-11
Identities = 184/941 (19%), Positives = 371/941 (39%), Gaps = 74/941 (7%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKE 167
L ++K ENL I++ +++ ++ EL + +M + L K
Sbjct: 1772 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI 1831
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYD-NTLSKL 226
V +LKK N L++K LE + + + + + E L L + D ++ +
Sbjct: 1832 VGELKKENSDLSEK---LEYFSCDHQ------ELLQRVETSEGLNSDLEMHADKSSREDI 1882
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++ N S + + +++EL R + + + ++ LE+ + L
Sbjct: 1883 GDNVAKVNDSWK-ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-----LE 1936
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
++NE + K + + E + S QL ++ SKK+ +D+ + + + T
Sbjct: 1937 KDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT-TALDQLSEKM------KEKTQ 1989
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
L+ + + I + ++ E E + D++E + + EKL SL +
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE----KDSQ 2045
Query: 404 ACNILRIQKE-RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
A ++ + + E +I +++ + +VK+ L+ L++ + K+++ + L+ L
Sbjct: 2046 ALSLTKCELENQIAQLNKEKEL-LVKESESLQARLSESDYE----KLNVSKALEAALVEK 2100
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEE 520
+ + + TQ E+ + IEK ++R+E K + D +E
Sbjct: 2101 GEFALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2158
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
E++ + EE +L + + A + +K EE+ A + + + + L SEK+N
Sbjct: 2159 LERELQ-MSEENQELVILDAENSKAEVETLKTQIEEM-ARSLKVFELDLVTLR-SEKENL 2215
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREK--ETQASELERSCQVIKQNGF-ELDKMKADI 637
++ L E + L S ++ ++ E Q E ++ + QN EL++ A +
Sbjct: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLE--QNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+E L + L + + +EK + C + +K E A++
Sbjct: 2276 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADL 2333
Query: 696 QNRMIMRLQKQIQ----EDDKLFIEKETKLNE---LTNKYEALKRDYDAAVKDLESSREA 748
+ L+++++ + +E E E L K E + + D+ + R
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
LT + + RI+ELE + + T E +
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2453
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
D ++ S+V L+ Q LD+ K Y L +QE
Sbjct: 2454 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN---GLIQEV 2510
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVD-R 926
++ +L+K+ ++++S LK QI+ Q Q V + ++ E L ++ V+
Sbjct: 2511 EDGKQKLEKK----DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKN--TVTKMQK-----AMEKYTKKDKEFEAKRK 979
KN L T+E L+ ++L+N +TKM K + K T K+ E + +
Sbjct: 2567 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626
Query: 980 ELEDCKAEL-EELKQRYKELDEECETCAEYLKQREEQCKRL 1019
E+ AEL EEL L E + E +K ++Q K L
Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Score = 67.7 bits (158), Expect = 2e-10
Identities = 177/964 (18%), Positives = 398/964 (41%), Gaps = 90/964 (9%)
Query: 55 ISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS 114
+S KM + +E + + L + ++KE+ L+ ++ + + L +++S
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS 2039
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD----- 169
LE ++ L + + +K+ L +E+++L + E+ E N++K ++
Sbjct: 2040 LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2099
Query: 170 ------DLKKNNECLTQKCIDLEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDN- 221
L E + Q +EKL V ++ +I + K +E SL +N
Sbjct: 2100 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENL 2159
Query: 222 ----TLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
+S+ N+ + + ++ TL+++++ K D ++++ E N+
Sbjct: 2160 ERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE----NL 2215
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
T + EK G+ +E + K++S K L EQ ++SK ++ ++ L + +
Sbjct: 2216 TKQIQEKQGQLSELD----KLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 338 AEFGTTSLDVFEILMD-NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A V + D I+ + LD +E+ +++ + + + L++ +K +
Sbjct: 2271 A--------VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 397 QLIEKENACNILRIQKERI-HEISSAVTID---IVKKENELKEILTKECLKLSKLKIDIP 452
QL E E+ ++L+ + E + E+ A T ++ EN E+ T + K+ + +
Sbjct: 2323 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA-KIEGMTQSL- 2380
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
R L+ D+ +TI + EL + I + ++ + + +
Sbjct: 2381 RGLELDV-----VTIRSEKENLTNELQKEQERISELEI-INSSFENILQEKEQEKVQMKE 2434
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+E ++K L+E + L+ + N LS +++ L++ + + +
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN----LSSQVECLEL---EKAQLLQ 2487
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L E N L S++NGL +E K +K+ + S L+ Q +Q +L +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQK----LEKKDEEISRLKNQIQDQEQLVSKLSQ 2543
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL--EINIKTHE 690
++ + + + + L +N +L++ E L E+ + +
Sbjct: 2544 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2603
Query: 691 KTAEIQ--NRMIMRLQKQIQEDDKLFIEKETKL-NELTNKYEALKRDYDAAVKDLESSRE 747
K + ++ N+M + + ++Q + +K +L EL+ + L + +++++SS++
Sbjct: 2604 KMSFVEKVNKMTAK-ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2662
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ +LT + ++ + + D + E+ V E
Sbjct: 2663 QLKELTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQLRL-------------HEAEK 2708
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAEYLQ 866
+ LD + + + + + E KE LS Q+ E+D LK +EL++ + + L+
Sbjct: 2709 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2768
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
E LKK K+ + V+ LK++ + + + K + E+ + + +
Sbjct: 2769 E-------LKKTKMDNLKYVNQLKKE---NERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2818
Query: 927 MSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
+ E +K +M T ++EL + ++LK T+ + K ++Y K ++LE K
Sbjct: 2819 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2878
Query: 986 AELE 989
LE
Sbjct: 2879 EMLE 2882
Score = 66.1 bits (154), Expect = 7e-10
Identities = 193/1032 (18%), Positives = 417/1032 (40%), Gaps = 98/1032 (9%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNL----TDSLKTKSKK 139
IKE++ + + QT D Q+K+ + L + K + N+ D L + ++
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
Query: 140 I-NELQEENDTL---SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ N L+E L + + + L + ++++KK N L + V E +
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 196 IGPKNICAQCKLKENLIQSL---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ KNI +N + + + + L L I+ S K+ ++L+
Sbjct: 509 L--KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQ 566
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI-KRNLNSLSE 311
R DC + + ++H+E L++KL + E E+KA+ E+ K+ L E
Sbjct: 567 R-DCSQ--DLLKKREHHIE--------QLNDKLSK-TEKESKALLSALELKKKEYEELKE 614
Query: 312 QLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYT 371
+ KS++ + LL +++E + ++ + QI E E+
Sbjct: 615 EKTLFSCWKSEN------EKLLTQMESEKENLQSKINH--LETCLKTQQIKSHEYNERVR 666
Query: 372 KVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE---RIH--EI------SS 420
++ D + E+++++ L S + ++ ++ A L+ + E + H EI +S
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 421 AVTIDIVKKENELK----EILTKE-CLKLSKLKIDIPRDLDQDLPA-------HKKITIL 468
+T + E++L+ EI+ K+ C + + + RDL + A H++ +
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 469 FDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL 528
FD + S + E+ + E + D+LE + K +
Sbjct: 787 FDQQPAMHH-SFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM 845
Query: 529 HEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS- 586
+ +L K + V + NL+K +E++ + +A+ +++ L E + +V+
Sbjct: 846 NSDLQKQCEELVQIKGEIEENLMK--AEQMH--QSFVAETSQRISKLQEDTSAHQNVVAE 901
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
T++ L+ + L+ LND + E + + EL++S +++ + EL + + +
Sbjct: 902 TLSALENKEKELQLLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
E + L ++N LKE ++ L ++ + + + I L Q
Sbjct: 961 IISLNKR---EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL 766
+++ + ++ + E N YE L + Y AA + +N+ T+ L E R EL
Sbjct: 1018 YKQEKLILLQ---RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS---LCENRKNEL 1071
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
E + E ++ D+ S
Sbjct: 1072 E-----QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN-----S 1121
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL--SLEQ 884
SE LK+ +++ ++E + +++ +L E E + ++ + E C L+ E + S+++
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE-CQNLESEPIRNSVKE 1180
Query: 885 QVSNLKEQIRTQQPVERQAKFADVAVNT-DEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ S + Q + ++ + K ++++++ + L +++ ++ E EK K ++
Sbjct: 1181 RESE-RNQCNFKPQMDLEVK--EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ-- 1235
Query: 944 EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECE 1003
EL+ + DL+ + + ++ E KD E +A+ K + EL + L +
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG-PHELSTSQNDNAHLQCSLQ 1294
Query: 1004 TCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
T L + E+ C+ L+ K L E+ D S A K E + + N +
Sbjct: 1295 TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK--LLNEVKILNDD 1352
Query: 1062 SAIVQNQQITDV 1073
S ++ + + D+
Sbjct: 1353 SGLLHGELVEDI 1364
Score = 64.1 bits (149), Expect = 3e-09
Identities = 141/735 (19%), Positives = 299/735 (40%), Gaps = 54/735 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL----E 116
++LK E+ L+ +L ++ +K L + Q + D L+S KSL E
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINEL-------QEENDTLSNLIMENVTESDNLNKEVD 169
+ +E K + L+ + K++NE QE + + E L ++
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTL-SKLNR 228
L+ E +K + + + + ESE+ + ++ ENL + L I N + L
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHAD----LLKGRV-ENLERELEIARTNQEHAALEA 2359
Query: 229 SISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGE 287
S T KI + L D + + ++ N L+ + ++ +++ E
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-LD 346
N E + KV + K +S + +++ + K+ + + + A E +S ++
Sbjct: 2420 NILQEKEQEKVQMKEK---SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE-------LKSVNEKLASLNSQLI 399
E+ ++ LDE Y +Q +N E L+ +E+++ L +Q+
Sbjct: 2477 CLELEKAQLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2532
Query: 400 EKENACNILRIQKERIHEISSAVTIDI----VKKENELKEILTKECLKLSKLKI--DIPR 453
++E + L Q E H++ +++ V+ E +++ + +K L++ +
Sbjct: 2533 DQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2591
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA-VXXXXXXXXXXXX 512
+L+ +L K + F + + T+ + E ++ +T + +
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2651
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ ++ + +++K L E ++L KS + + + EEI ++ + + E+K
Sbjct: 2652 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ 2711
Query: 573 SLSEKDNKLTEL-VSTINGL---KEENNSLKSLN-DVITREKETQASELERSCQVIKQNG 627
+L NK E+ + T KEE S + L D++ KE + L+ + Q+++
Sbjct: 2712 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE--- 2768
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
EL K K D L + K L++ L+E+ E ++ S+L+ +
Sbjct: 2769 -ELKKTKMDNLKYVNQLKKENERAQG---KMKLLIKSCKQLEEEKEILQKELSQLQA-AQ 2823
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+KT + + + L +I+E + EK + +E +KY +L ++ K E
Sbjct: 2824 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2883
Query: 748 AVNQLTTQKDLVEGR 762
V L +Q+ + R
Sbjct: 2884 QVAHLCSQQSKQDSR 2898
Score = 61.7 bits (143), Expect = 1e-08
Identities = 190/989 (19%), Positives = 410/989 (41%), Gaps = 110/989 (11%)
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+D LK N+ L K +LE + E ++ G N + +L+ + I + L+K
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ T+ +Y++ T + L+ + K+L ED + + + E ++ + EK
Sbjct: 340 RDELV--RTTAQYDQASTKYTALE---QKLKKLTEDLSCQRQNAESARCSLEQKIKEK-- 392
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
EF+ + +S +R+ +L ++ I +++ +++ + + K+ + VL AE L
Sbjct: 393 -EKEFQEE----LSRQQRSFQTLDQECIQMKARLTQE-LQQAKN-MHNVLQAELD--KLT 443
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLI---- 399
+ ++N + +++ L + + Q +L E+K N L S + Q
Sbjct: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 400 ----EKENACNILRIQKERIHEISSAVTI------DIVKKENELKEILTKECLKLSKLKI 449
E +N L + E+ + T D+ +K N+ + LT E LKL+ +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 450 DIPRDLDQDLPAHKK--ITILFD----------ALITQYELSRTDYEIEKEKLRLET--- 494
+ RD QDL ++ I L D AL++ EL + +YE KE+ L +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEA--HNEVKSLHEELTKLYKSKVDENNANL---NL 549
+ + + LE ++KS HE ++ ++D N ++ NL
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLETCLKTQQIKS-HEYNERVRTLEMDRENLSVEIRNL 682
Query: 550 IKIL---SEEIDALKIAIAKNEEKMLSLSEKDNKLTELV----STINGLKEE-NNSLKSL 601
+L S E++ K+A + ++K +K K E + S + G E+ + L+ L
Sbjct: 683 HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
Query: 602 -NDVITREKETQA--SELERSCQVIKQNGFEL--DKMKADILMXXXXXXXXXXXXXXXXD 656
N+++ +++ Q +E E ++K L ++ L+
Sbjct: 743 SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
E S+ + + + ++ ++ + L+ + + E + E Q +M LQKQ +E ++ E
Sbjct: 803 EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK-DLVEGRIAELE---SDIRT 772
E L + +++ + + L+ A + + +E + EL+ + T
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
Query: 773 EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQ 832
EQ T E +++ L+ KR I ++ E
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN---KREIEELTQ-ENGT 978
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQ---Q 885
LKE S QE +L ++ E+ A Y+ ER++ + L K+EKL L Q +
Sbjct: 979 LKEINASLNQEKMNLIQK-------SESFANYIDEREKSISELSDQYKQEKLILLQRCEE 1031
Query: 886 VSNLKEQI--RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
N E + + + E+ +K + +N ++++ +A ++++ + +
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKL-ECLLNECTSLCENRKNELEQLK-EAFAKEHQEFLTKL 1089
Query: 944 EELRYKKQDLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ Q+L + +Q+A+ + E ++E+ K E ++++ +L
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-----NQKVALEKQIESLSNTPVSN 1053
+E E + +K + E C+ L+ I + ++ S N K ++ +++ +S + +
Sbjct: 1150 LQENEQLMKVMKTKHE-CQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS---LDS 1205
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ A+++N+++ ++E++K K+
Sbjct: 1206 YNAQLVQLEAMLRNKELK--LQESEKEKE 1232
Score = 59.7 bits (138), Expect = 6e-08
Identities = 189/970 (19%), Positives = 386/970 (39%), Gaps = 75/970 (7%)
Query: 114 SLEMENLTKD-------KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
SL+ ENLT+ K ++ L + + + +L+E+ + S IM+N E L +
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME--SQGIMKN-KEIQELEQ 1586
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+ ++ +CL ++ + + + + K+ + + KL Q+ + + +++L
Sbjct: 1587 LLSSERQELDCLRKQYLSENE---QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1643
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ + S+R + + E C E + H+ + D D +
Sbjct: 1644 Q--LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQD 1701
Query: 287 ENNEFE----TKAVKVMSEI--KRNLNSLSEQLINNESKKSKDHIDRYKDS---LLAVLD 337
N + E T AVK E +++ ++ E ++++ S + I S L +D
Sbjct: 1702 LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMD 1761
Query: 338 AEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ ++ + N+ L I ++ KV+ LNE +K ++ KL Q
Sbjct: 1762 FLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE----MKELDSKLHLQEVQ 1817
Query: 398 LIEKENAC----NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L+ K AC I+ K+ ++S + + L+ + T E L S L++ +
Sbjct: 1818 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN-SDLEMHADK 1876
Query: 454 DLDQDLPAH-KKITILFDA--LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXX 510
+D+ + K+ + L + ELSR I EK +E
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSR----IRSEKASIEHEALYLEADLEVVQTEK 1932
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
D E + L EEL+ + E N + +S++ AL K +EK
Sbjct: 1933 LCLEKDN-ENKQKVIVCLEEELSVV----TSERNQLRGELDTMSKKTTALDQLSEKMKEK 1987
Query: 571 MLSLSEKDNKLTELVSTING-LKEENNSLKSLN-DV--ITREK---ETQASELERSCQVI 623
L ++ + +KE+ L++L+ DV + ++K + + LE+ Q +
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2047
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK-SLLEQNLALKEQCEEKTRDCSRL 682
EL+ A + E+ L + AL+ EK RL
Sbjct: 2048 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
T E+ +++ R I +L+ +I+ D+K + KL E + ++LK + ++L
Sbjct: 2108 S---STQEEVHQLR-RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2163
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ S E NQ D E AE+E+ ++T+ +
Sbjct: 2164 QMSEE--NQELVILD-AENSKAEVET-LKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 2219
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET- 860
++ L E KL S K + +E+ Q+KE + ++ L+ + KEL++
Sbjct: 2220 QEKQGQLSELDKLLSSFKSLLEEKEQAEI-QIKEE---SKTAVEMLQNQLKELNEAVAAL 2275
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VNTDEDWANL 919
C + QE + + + E Q+ N E++R + + + + + + E A+L
Sbjct: 2276 CGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL 2333
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
V+ + + E+ + + +E K +++ K++ + + + R
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-AKIALEIVDKLSNQKVA 1038
E E+ EL++ ++R EL+ + L+++E++ ++KE + A+E+ L Q
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM---LQTQLKE 2449
Query: 1039 LEKQIESLSN 1048
L +++ +L N
Sbjct: 2450 LNERVAALHN 2459
Score = 58.8 bits (136), Expect = 1e-07
Identities = 198/1024 (19%), Positives = 398/1024 (38%), Gaps = 99/1024 (9%)
Query: 59 MCQSLKESSN--EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLE 116
M + L+E N E +L LEKL + D+++Q+ ++DLL + +E
Sbjct: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC-------------SQDLLKKREHHIE 582
Query: 117 MEN--LTK-DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK 173
N L+K +KE K L +L+ K K+ EL+EE S EN + E ++L+
Sbjct: 583 QLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQS 642
Query: 174 NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDS 233
L + C+ +++ + N + + +ENL S+ I L+ +
Sbjct: 643 KINHL-ETCLKTQQIKSHEYN----ERVRTLEMDRENL--SVEI------RNLHNVLDSK 689
Query: 234 NTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
+ K+ ++ + A +F+ K+ E+ NM + + G+ + E
Sbjct: 690 SVEVETQKLAYMELQQKA----------EFSDQKHQKEIE--NMCLKTSQLTGQVEDLEH 737
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
K + +EI Q ++ E + +D + SL+ D + + D +
Sbjct: 738 KLQLLSNEIMD--KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHH 795
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
+ N + + + ++ + + ++ + ++ SL L ++ + L+ Q E
Sbjct: 796 SFANIIG-EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID-------IPRDLDQDLPAHKKIT 466
+ +I + +++K E + + + ++SKL+ D + L K++
Sbjct: 855 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Query: 467 ILFDALITQ----YELSRTDYEIEK--EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+L D + T+ EL ++++ +E ++L+L + T + L +
Sbjct: 915 LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL---SEK 577
+ +K ++ L + + + ++ + N I + I +++ +EK++ L E
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS--ELSDQYKQEKLILLQRCEET 1032
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N +L +E+N+ L+ L + T E + +ELE+ +K+ K +
Sbjct: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ----LKE---AFAKEHQEF 1085
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
L + + L + Q K+ + L+ I T E QN
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMT-DNQNNSKS-EAGGLKQEIMT---LKEEQN 1140
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+M + +QE+++L +TK +E N R+ +VK+ ES R N Q D
Sbjct: 1141 KMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRN---SVKERESERNQCN-FKPQMD 1195
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDEN-RDLGENPKLDD 816
L + E+ D Q + + R E L D
Sbjct: 1196 L---EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQD 1252
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
+ IS + D E+ +E+ +S EL + L +T L E ++ C L+
Sbjct: 1253 MQSQEISGLKDCEI-DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
Query: 877 KEKLSLEQQVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYDAEV 933
EK L ++++ + + T++ E K + ++D LH +V D +
Sbjct: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
Query: 934 EKNKR----LMKTIEELRYKKQDLKNTVTKMQKA--MEKYTKKDKEFEAKRKELEDCKAE 987
+ N++ L E Y+ L + +M A EK+ E + + ++
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSK 1431
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE--IVDKLSNQKVALEKQIES 1045
+ EL+ L E + L R Q +KE ++ LE +V LS+ V + S
Sbjct: 1432 MSELQTYVDSLKAENLVLSTNL--RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSS 1489
Query: 1046 LSNT 1049
L ++
Sbjct: 1490 LGDS 1493
Score = 56.4 bits (130), Expect = 5e-07
Identities = 186/857 (21%), Positives = 341/857 (39%), Gaps = 91/857 (10%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-----I 302
EL D E E F+ +H EL + T + G N++ E A K E +
Sbjct: 1834 ELKKENSDLSEKLEYFSC--DHQELLQRVETSE-----GLNSDLEMHADKSSREDIGDNV 1886
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAV-LDAEFGTTSLDVFEILMDNIINKYQI 361
+ +S E+ ++ E++ S+ ++ A+ L+A+ + + DN NK ++
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE-NKQKV 1945
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEIS 419
+ + E+ + V + N+ EL ++++K +L+ QL EK E + Q E +H I
Sbjct: 1946 IVC-LEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEKTQELESHQSECLHCIQ 2003
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
A VK++ EL + L+ + +L K K + L Q L + L T+ EL
Sbjct: 2004 VAEAE--VKEKTELLQTLSSDVSELLKDKTHLQEKL-QSLEKDSQALSL-----TKCELE 2055
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
++ KEK L V ++ L N K+L L + +
Sbjct: 2056 NQIAQLNKEKELL-------VKESESLQARLSESDYEKL----NVSKALEAALVEKGEFA 2104
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+ ++ + + L I+ L++ I +E+K L ++EK + + EN+SLK
Sbjct: 2105 LRLSSTQEEVHQ-LRRGIEKLRVRIEADEKKQLHIAEK----------LKERERENDSLK 2153
Query: 600 SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK 659
+ V E+E Q SE + ++ + + KA++ +
Sbjct: 2154 --DKVENLERELQMSEENQELVIL-----DAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-E 718
+L + L +Q +EK S L+ + + + E + + + QI+E+ K +E +
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA----EIQIKEESKTAVEMLQ 2262
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
+L EL AL D + +S + + ++ +E A LE+D + +Q +
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK-KQLCVL 2321
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
+ R E+ L+ S EV LK ++
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-------SKGEVETLKAKIE 2374
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
Q L L+ + E E LQ+ E+ + L+ S E + KEQ + Q
Sbjct: 2375 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE-KEQEKVQ-- 2431
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ ++ A + T N V +A K + L +E L +K L +
Sbjct: 2432 MKEKSSTAMEMLQTQLKELN-ERVAALHNDQEACKAKEQNLSSQVECLELEKAQL---LQ 2487
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
+ +A Y +E+ED K +LE+ DEE ++ +E+ +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK-------KDEEISRLKNQIQDQEQLVSK 2540
Query: 1019 LK----EAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGS-AIVQNQ-QIT 1071
L E ++ E +L N V LE++I+ L + S T+ V S ++N+ ++T
Sbjct: 2541 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 1072 --DVMKENQKLKKMNAK 1086
D M +K+ KM AK
Sbjct: 2601 KMDKMSFVEKVNKMTAK 2617
Score = 44.0 bits (99), Expect = 0.003
Identities = 55/254 (21%), Positives = 106/254 (41%), Gaps = 22/254 (8%)
Query: 847 LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+KE+ KE +E Q D++C ++K QQ N+ + Q +++
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVL--QAELDKLTSVK 446
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
N E++ + ++ A K L +++EE++ + LK+ QKA E
Sbjct: 447 QQLENNLEEFK--QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS--HSEQKAREV 502
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQR---EEQCKRLKEAK 1023
EA+ K ++ C + + + K + ET L+++ +E L++ K
Sbjct: 503 C-----HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 1024 IALEIVDKLSNQKVAL----EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
+A+ ++K + L E IE L++ A SA+ ++ + +KE +
Sbjct: 558 LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 1080 L----KKMNAKLIT 1089
L K N KL+T
Sbjct: 618 LFSCWKSENEKLLT 631
>AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 87.0 bits (206), Expect = 3e-16
Identities = 207/1024 (20%), Positives = 438/1024 (42%), Gaps = 112/1024 (10%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
+ EL I+ +K+++E ++ L LE +++ ++ LE +N K K I L + L
Sbjct: 1900 VENELSRIRSEKASIE--HEALYLEADL-EVVQTEKLCLEKDNENKQKVIVCLEEELSVV 1956
Query: 137 SKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
+ + N+L+ E DT+S + T D L++++ + + E +C+ + +E ++
Sbjct: 1957 TSERNQLRGELDTMS----KKTTALDQLSEKMKEKTQELESHQSECL---HCIQVAEAEV 2009
Query: 197 GPKNICAQCKLKENLIQSLHIGYDNT-LSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
K Q L ++ + L D T L + +S+ + + K C L++++ ++
Sbjct: 2010 KEKTELLQ-TLSSDVSELLK---DKTHLQEKLQSLEKDSQALSLTK-CELENQIAQLNKE 2064
Query: 256 CKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEF------------------ETK 294
+ L ++ S++ L + + N++ L+ L E EF E
Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124
Query: 295 AVKVMSEIKRNLN---SLSEQLINNESKKSK-DHIDR-----YKDSLLAVLDAEFGTTSL 345
V++ ++ K+ L+ L E+ N+S K K ++++R ++ L +LDAE +
Sbjct: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 346 DVFEILMDNI---INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + ++ + + +++DL + + + + E +L +++ L+S S L EKE
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 403 NACNILRIQKERIHEISSAVTIDIVKKENELKEIL--TKECLKLSKLKIDIPRDLDQDL- 459
A IQ + + + + + +K+ NE L +E +K ++ +D P + + L
Sbjct: 2245 QA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2300
Query: 460 PAHKKITILFDA-----LITQYELSRTDYEIEKEKLRLET--GTAKAVXXXXXXXXXXXX 512
+ +K+ +A L +L +++ + K R+E +
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE 2360
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKI------- 562
+E +++ + + L L V + NL L +E I L+I
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFEN 2420
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL-ND-VITREKETQASELERSC 620
+ + E++ + + EK + E++ T LKE N + +L ND + KE S
Sbjct: 2421 ILQEKEQEKVQMKEKSSTAMEMLQT--QLKELNERVAALHNDQEACKAKEQNLSSQVECL 2478
Query: 621 QVIKQNGFE-LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ K + LD+ K + ++ + + E+ LK Q +++ +
Sbjct: 2479 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2538
Query: 680 SRLEINIKTH----EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
S+L H E+ E++N + + L+++IQ + L L + Y+ L+ +
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRN-LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597
Query: 736 DAAVKDLESSREAVNQLTT-----QKDLVE--GRIAELESDIRTEQTATVXXXXXXXXXX 788
+ D S E VN++T Q+++ E + AEL+ ++ E+
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD--SEVSQLKERLLSCQQELDD 846
EN +L ++ LD K + E+++ + RL +++
Sbjct: 2658 KSSKDQLKELTL---ENSELKKS--LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2712
Query: 847 -LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
L + K+ + E +T E L + E+C L +KL ++ S+ KE++ ++ +
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSK-EEC--LSSQKLEIDLLKSS-KEELNNS--LKATTQI 2766
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
+ T D NL V + + K K L+K+ ++L +K+ L+ ++++Q A E
Sbjct: 2767 LEELKKTKMD--NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824
Query: 966 KY---TKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K T D + + E+++ K LEE K+ + LD+ C + ++ E+ K + E
Sbjct: 2825 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH--EKLEKAKEMLE 2882
Query: 1022 AKIA 1025
++A
Sbjct: 2883 TQVA 2886
Score = 77.4 bits (182), Expect = 3e-13
Identities = 213/1013 (21%), Positives = 386/1013 (38%), Gaps = 74/1013 (7%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ L L K +E++ D LK K+ + Q + D+L + + + +N E +LK
Sbjct: 10 EGLPTRALQKIQELEGQLDKLK---KEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ N+ L + C LEK + +++ K +Q +E + S + +L R S+
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKE--SQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
S + QS D C + FT+ + + + DL EK N E E
Sbjct: 125 LERSQQ-----AAQS-ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY--NKEVE 176
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE--- 349
+ ++ +E+K + Q + + +D S + E + L
Sbjct: 177 ERK-RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT 235
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLIEKENACN 406
+ + Y E+ + +Q D N + S L L +Q E N N
Sbjct: 236 PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 407 ILRI-----QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
L + +KE +++ + + + E E++ KE + L+K + ++ R Q A
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQL-QLEKAKVELIEKEKV-LNKCRDELVRTTAQYDQA 353
Query: 462 HKKITILFDAL--ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
K T L L +T+ +LS E + LE K F TL+
Sbjct: 354 STKYTALEQKLKKLTE-DLSCQRQNAESARCSLEQ-KIKEKEKEFQEELSRQQRSFQTLD 411
Query: 520 EAHNEVKS-LHEEL--TKLYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLS 575
+ ++K+ L +EL K + + L +K L ++ K + + E+ +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K+N EL ++ +K+ENN LKS ++ RE +EL+ Q + Q+ ++MKA
Sbjct: 472 IKEN---ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA 528
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ SL + L L EK RDCS + +K E E
Sbjct: 529 ---KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS--QDLLKKREHHIEQ 583
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
N +L K +E L E K E YE LK + + + + Q+ ++
Sbjct: 584 LND---KLSKTEKESKALLSALELKKKE----YEELKEEKTLFSCWKSENEKLLTQMESE 636
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG---DENRDLGENP 812
K+ ++ +I LE+ ++T+Q + D E
Sbjct: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
Query: 813 KLDDSPKRSISVISDSE-VSQLKERLLSCQQ---ELDDLKERYKELDDEC---ETCAEYL 865
KL + + SD + +++ L Q +++DL+ + + L +E + C + L
Sbjct: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
Query: 866 QERDEQCARLKKEK-LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
E L K K SL + + + Q FA++ + + S
Sbjct: 757 HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI-IGEQGSMPSERSEC- 814
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
R+ D + + L ++ L + + K + +QK E+ + E E + E
Sbjct: 815 -RLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 985 -KAELEELKQRYKELDEEC----ETCAEYLKQREEQCKRLK--EAKIALE--IVDKLSNQ 1035
++ + E QR +L E+ AE L E + K L+ K+ E + +L
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS 933
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQKLKKMNAKL 1087
LE ++ L + S S I N ++I ++ +EN LK++NA L
Sbjct: 934 NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
Score = 75.8 bits (178), Expect = 8e-13
Identities = 206/989 (20%), Positives = 415/989 (41%), Gaps = 99/989 (10%)
Query: 65 ESSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
E NE K + L EL + +++ L G+ + +T D L ++K E +
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 124 KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT-QKC 182
E + + + K+ EL + TLS+ + E + + +L +++ L+K+++ L+ KC
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQ---TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2052
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
E EN+I N + +KE+ + ++ KLN +S + + K
Sbjct: 2053 --------ELENQIAQLNKEKELLVKESESLQARLS-ESDYEKLN--VSKALEAALVEK- 2100
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEP---NMTMDLDEKLGENNEFETKAVKVM 299
L + +E+ +L ++ +E E ++ L E+ EN+ + K +
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
E++ ++ +++L+ +++ SK ++ K + E SL VFE+ + + ++
Sbjct: 2161 RELQ--MSEENQELVILDAENSKAEVETLKTQI------EEMARSLKVFELDLVTLRSEK 2212
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK-ENACNILRIQKERIHEI 418
+ +I EK ++ +L++ S KS+ E+ Q+ E+ + A +L+ Q + ++E
Sbjct: 2213 ENLTKQIQEKQGQLS-ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2271
Query: 419 SSAVTID--IVKK-ENELKEILTKECL---KLSKLKIDIPRDLDQDLPAHKKITIL---F 469
+A+ D I+K E L + +E + KL+ + D + L +++
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 470 DALITQYELSRTDYEIEK---EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
D L + E + EI + E LE +K LE ++
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2391
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
S E LT + K E + L +I E I + + E++ + + EK + E++
Sbjct: 2392 SEKENLTNELQ-KEQERISELEIINSSFENI------LQEKEQEKVQMKEKSSTAMEMLQ 2444
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
T LKE N + +L++ ++ +A E S QV EL+K A +L
Sbjct: 2445 T--QLKELNERVAALHN---DQEACKAKEQNLSSQV---ECLELEK--AQLLQGLDEAKN 2494
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+ L+++ K++ E+K + SRL+ I+ E+ ++ +L Q
Sbjct: 2495 NYIVLQSSVN---GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-------LVSKLS-Q 2543
Query: 707 IQEDDKLFIEKETKLNELTNKYEA---LKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
++ + +L+ E+ +L LT + E + + +A+++D LE + + L + +L +
Sbjct: 2544 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT--K 2601
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI 822
+ ++ + + G++NR GE L + K S
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 823 SVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
+ + E S+LK+ L C + D E+ ++ +E AEY E A K + L
Sbjct: 2662 DQLKELTLENSELKKSL-DCMHK--DQVEKEGKVREEI---AEYQLRLHE--AEKKHQAL 2713
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN--KR 938
L+ +N + ++ Q E+ + + E+ + + +D + E N K
Sbjct: 2714 LLD---TNKQYEVEIQTYREK--------LTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ +EEL+ K D V +++K E+ K K K+LE+ K L++ + +
Sbjct: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2822
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALE 1027
E+ +T + +E +KE K LE
Sbjct: 2823 QEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Score = 72.1 bits (169), Expect = 1e-11
Identities = 184/941 (19%), Positives = 371/941 (39%), Gaps = 74/941 (7%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKE 167
L ++K ENL I++ +++ ++ EL + +M + L K
Sbjct: 1772 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI 1831
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYD-NTLSKL 226
V +LKK N L++K LE + + + + + E L L + D ++ +
Sbjct: 1832 VGELKKENSDLSEK---LEYFSCDHQ------ELLQRVETSEGLNSDLEMHADKSSREDI 1882
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++ N S + + +++EL R + + + ++ LE+ + L
Sbjct: 1883 GDNVAKVNDSWK-ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC-----LE 1936
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
++NE + K + + E + S QL ++ SKK+ +D+ + + + T
Sbjct: 1937 KDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT-TALDQLSEKM------KEKTQ 1989
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
L+ + + I + ++ E E + D++E + + EKL SL +
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE----KDSQ 2045
Query: 404 ACNILRIQKE-RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAH 462
A ++ + + E +I +++ + +VK+ L+ L++ + K+++ + L+ L
Sbjct: 2046 ALSLTKCELENQIAQLNKEKEL-LVKESESLQARLSESDYE----KLNVSKALEAALVEK 2100
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEE 520
+ + + TQ E+ + IEK ++R+E K + D +E
Sbjct: 2101 GEFALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2158
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
E++ + EE +L + + A + +K EE+ A + + + + L SEK+N
Sbjct: 2159 LERELQ-MSEENQELVILDAENSKAEVETLKTQIEEM-ARSLKVFELDLVTLR-SEKENL 2215
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREK--ETQASELERSCQVIKQNGF-ELDKMKADI 637
++ L E + L S ++ ++ E Q E ++ + QN EL++ A +
Sbjct: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLE--QNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+E L + L + + +EK + C + +K E A++
Sbjct: 2276 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADL 2333
Query: 696 QNRMIMRLQKQIQ----EDDKLFIEKETKLNE---LTNKYEALKRDYDAAVKDLESSREA 748
+ L+++++ + +E E E L K E + + D+ + R
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
LT + + RI+ELE + + T E +
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2453
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
D ++ S+V L+ Q LD+ K Y L +QE
Sbjct: 2454 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN---GLIQEV 2510
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVD-R 926
++ +L+K+ ++++S LK QI+ Q Q V + ++ E L ++ V+
Sbjct: 2511 EDGKQKLEKK----DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKN--TVTKMQK-----AMEKYTKKDKEFEAKRK 979
KN L T+E L+ ++L+N +TKM K + K T K+ E + +
Sbjct: 2567 QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626
Query: 980 ELEDCKAEL-EELKQRYKELDEECETCAEYLKQREEQCKRL 1019
E+ AEL EEL L E + E +K ++Q K L
Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Score = 67.7 bits (158), Expect = 2e-10
Identities = 177/964 (18%), Positives = 398/964 (41%), Gaps = 90/964 (9%)
Query: 55 ISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS 114
+S KM + +E + + L + ++KE+ L+ ++ + + L +++S
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS 2039
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD----- 169
LE ++ L + + +K+ L +E+++L + E+ E N++K ++
Sbjct: 2040 LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2099
Query: 170 ------DLKKNNECLTQKCIDLEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDN- 221
L E + Q +EKL V ++ +I + K +E SL +N
Sbjct: 2100 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENL 2159
Query: 222 ----TLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
+S+ N+ + + ++ TL+++++ K D ++++ E N+
Sbjct: 2160 ERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE----NL 2215
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
T + EK G+ +E + K++S K L EQ ++SK ++ ++ L + +
Sbjct: 2216 TKQIQEKQGQLSELD----KLLSSFKSLLEE-KEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 338 AEFGTTSLDVFEILMD-NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A V + D I+ + LD +E+ +++ + + + L++ +K +
Sbjct: 2271 A--------VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 397 QLIEKENACNILRIQKERI-HEISSAVTID---IVKKENELKEILTKECLKLSKLKIDIP 452
QL E E+ ++L+ + E + E+ A T ++ EN E+ T + K+ + +
Sbjct: 2323 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA-KIEGMTQSL- 2380
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
R L+ D+ +TI + EL + I + ++ + + +
Sbjct: 2381 RGLELDV-----VTIRSEKENLTNELQKEQERISELEI-INSSFENILQEKEQEKVQMKE 2434
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+E ++K L+E + L+ + N LS +++ L++ + + +
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN----LSSQVECLEL---EKAQLLQ 2487
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L E N L S++NGL +E K +K+ + S L+ Q +Q +L +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQK----LEKKDEEISRLKNQIQDQEQLVSKLSQ 2543
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL--EINIKTHE 690
++ + + + + L +N +L++ E L E+ + +
Sbjct: 2544 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2603
Query: 691 KTAEIQ--NRMIMRLQKQIQEDDKLFIEKETKL-NELTNKYEALKRDYDAAVKDLESSRE 747
K + ++ N+M + + ++Q + +K +L EL+ + L + +++++SS++
Sbjct: 2604 KMSFVEKVNKMTAK-ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKD 2662
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ +LT + ++ + + D + E+ V E
Sbjct: 2663 QLKELTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQLRL-------------HEAEK 2708
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAEYLQ 866
+ LD + + + + + E KE LS Q+ E+D LK +EL++ + + L+
Sbjct: 2709 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE 2768
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
E LKK K+ + V+ LK++ + + + K + E+ + + +
Sbjct: 2769 E-------LKKTKMDNLKYVNQLKKE---NERAQGKMKLLIKSCKQLEEEKEILQKELSQ 2818
Query: 927 MSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
+ E +K +M T ++EL + ++LK T+ + K ++Y K ++LE K
Sbjct: 2819 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAK 2878
Query: 986 AELE 989
LE
Sbjct: 2879 EMLE 2882
Score = 66.1 bits (154), Expect = 7e-10
Identities = 193/1032 (18%), Positives = 417/1032 (40%), Gaps = 98/1032 (9%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNL----TDSLKTKSKK 139
IKE++ + + QT D Q+K+ + L + K + N+ D L + ++
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
Query: 140 I-NELQEENDTL---SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ N L+E L + + + L + ++++KK N L + V E +
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 196 IGPKNICAQCKLKENLIQSL---HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ KNI +N + + + + L L I+ S K+ ++L+
Sbjct: 509 L--KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQ 566
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI-KRNLNSLSE 311
R DC + + ++H+E L++KL + E E+KA+ E+ K+ L E
Sbjct: 567 R-DCSQ--DLLKKREHHIE--------QLNDKLSK-TEKESKALLSALELKKKEYEELKE 614
Query: 312 QLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYT 371
+ KS++ + LL +++E + ++ + QI E E+
Sbjct: 615 EKTLFSCWKSEN------EKLLTQMESEKENLQSKINH--LETCLKTQQIKSHEYNERVR 666
Query: 372 KVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE---RIH--EI------SS 420
++ D + E+++++ L S + ++ ++ A L+ + E + H EI +S
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 421 AVTIDIVKKENELK----EILTKE-CLKLSKLKIDIPRDLDQDLPA-------HKKITIL 468
+T + E++L+ EI+ K+ C + + + RDL + A H++ +
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 469 FDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL 528
FD + S + E+ + E + D+LE + K +
Sbjct: 787 FDQQPAMHH-SFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM 845
Query: 529 HEELTKLYKSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS- 586
+ +L K + V + NL+K +E++ + +A+ +++ L E + +V+
Sbjct: 846 NSDLQKQCEELVQIKGEIEENLMK--AEQMH--QSFVAETSQRISKLQEDTSAHQNVVAE 901
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
T++ L+ + L+ LND + E + + EL++S +++ + EL + + +
Sbjct: 902 TLSALENKEKELQLLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
E + L ++N LKE ++ L ++ + + + I L Q
Sbjct: 961 IISLNKR---EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL 766
+++ + ++ + E N YE L + Y AA + +N+ T+ L E R EL
Sbjct: 1018 YKQEKLILLQ---RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS---LCENRKNEL 1071
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
E + E ++ D+ S
Sbjct: 1072 E-----QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN-----S 1121
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL--SLEQ 884
SE LK+ +++ ++E + +++ +L E E + ++ + E C L+ E + S+++
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE-CQNLESEPIRNSVKE 1180
Query: 885 QVSNLKEQIRTQQPVERQAKFADVAVNT-DEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ S + Q + ++ + K ++++++ + L +++ ++ E EK K ++
Sbjct: 1181 RESE-RNQCNFKPQMDLEVK--EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ-- 1235
Query: 944 EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECE 1003
EL+ + DL+ + + ++ E KD E +A+ K + EL + L +
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG-PHELSTSQNDNAHLQCSLQ 1294
Query: 1004 TCAEYLKQREEQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
T L + E+ C+ L+ K L E+ D S A K E + + N +
Sbjct: 1295 TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK--LLNEVKILNDD 1352
Query: 1062 SAIVQNQQITDV 1073
S ++ + + D+
Sbjct: 1353 SGLLHGELVEDI 1364
Score = 64.1 bits (149), Expect = 3e-09
Identities = 141/735 (19%), Positives = 299/735 (40%), Gaps = 54/735 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL----E 116
++LK E+ L+ +L ++ +K L + Q + D L+S KSL E
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINEL-------QEENDTLSNLIMENVTESDNLNKEVD 169
+ +E K + L+ + K++NE QE + + E L ++
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTL-SKLNR 228
L+ E +K + + + + ESE+ + ++ ENL + L I N + L
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHAD----LLKGRV-ENLERELEIARTNQEHAALEA 2359
Query: 229 SISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGE 287
S T KI + L D + + ++ N L+ + ++ +++ E
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-LD 346
N E + KV + K +S + +++ + K+ + + + A E +S ++
Sbjct: 2420 NILQEKEQEKVQMKEK---SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE-------LKSVNEKLASLNSQLI 399
E+ ++ LDE Y +Q +N E L+ +E+++ L +Q+
Sbjct: 2477 CLELEKAQLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2532
Query: 400 EKENACNILRIQKERIHEISSAVTIDI----VKKENELKEILTKECLKLSKLKI--DIPR 453
++E + L Q E H++ +++ V+ E +++ + +K L++ +
Sbjct: 2533 DQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2591
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA-VXXXXXXXXXXXX 512
+L+ +L K + F + + T+ + E ++ +T + +
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2651
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ ++ + +++K L E ++L KS + + + EEI ++ + + E+K
Sbjct: 2652 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ 2711
Query: 573 SLSEKDNKLTEL-VSTINGL---KEENNSLKSLN-DVITREKETQASELERSCQVIKQNG 627
+L NK E+ + T KEE S + L D++ KE + L+ + Q+++
Sbjct: 2712 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE--- 2768
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
EL K K D L + K L++ L+E+ E ++ S+L+ +
Sbjct: 2769 -ELKKTKMDNLKYVNQLKKENERAQG---KMKLLIKSCKQLEEEKEILQKELSQLQA-AQ 2823
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+KT + + + L +I+E + EK + +E +KY +L ++ K E
Sbjct: 2824 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2883
Query: 748 AVNQLTTQKDLVEGR 762
V L +Q+ + R
Sbjct: 2884 QVAHLCSQQSKQDSR 2898
Score = 61.7 bits (143), Expect = 1e-08
Identities = 190/989 (19%), Positives = 410/989 (41%), Gaps = 110/989 (11%)
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+D LK N+ L K +LE + E ++ G N + +L+ + I + L+K
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ T+ +Y++ T + L+ + K+L ED + + + E ++ + EK
Sbjct: 340 RDELV--RTTAQYDQASTKYTALE---QKLKKLTEDLSCQRQNAESARCSLEQKIKEK-- 392
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
EF+ + +S +R+ +L ++ I +++ +++ + + K+ + VL AE L
Sbjct: 393 -EKEFQEE----LSRQQRSFQTLDQECIQMKARLTQE-LQQAKN-MHNVLQAELD--KLT 443
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQ---GDLNECTSELKSVNEKLASLNSQLI---- 399
+ ++N + +++ L + + Q +L E+K N L S + Q
Sbjct: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 400 ----EKENACNILRIQKERIHEISSAVTI------DIVKKENELKEILTKECLKLSKLKI 449
E +N L + E+ + T D+ +K N+ + LT E LKL+ +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 450 DIPRDLDQDLPAHKK--ITILFD----------ALITQYELSRTDYEIEKEKLRLET--- 494
+ RD QDL ++ I L D AL++ EL + +YE KE+ L +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEA--HNEVKSLHEELTKLYKSKVDENNANL---NL 549
+ + + LE ++KS HE ++ ++D N ++ NL
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLETCLKTQQIKS-HEYNERVRTLEMDRENLSVEIRNL 682
Query: 550 IKIL---SEEIDALKIAIAKNEEKMLSLSEKDNKLTELV----STINGLKEE-NNSLKSL 601
+L S E++ K+A + ++K +K K E + S + G E+ + L+ L
Sbjct: 683 HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
Query: 602 -NDVITREKETQA--SELERSCQVIKQNGFEL--DKMKADILMXXXXXXXXXXXXXXXXD 656
N+++ +++ Q +E E ++K L ++ L+
Sbjct: 743 SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
E S+ + + + ++ ++ + L+ + + E + E Q +M LQKQ +E ++ E
Sbjct: 803 EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK-DLVEGRIAELE---SDIRT 772
E L + +++ + + L+ A + + +E + EL+ + T
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
Query: 773 EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQ 832
EQ T E +++ L+ KR I ++ E
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN---KREIEELTQ-ENGT 978
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQ---Q 885
LKE S QE +L ++ E+ A Y+ ER++ + L K+EKL L Q +
Sbjct: 979 LKEINASLNQEKMNLIQK-------SESFANYIDEREKSISELSDQYKQEKLILLQRCEE 1031
Query: 886 VSNLKEQI--RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
N E + + + E+ +K + +N ++++ +A ++++ + +
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKL-ECLLNECTSLCENRKNELEQLK-EAFAKEHQEFLTKL 1089
Query: 944 EELRYKKQDLKNTVTKMQKAM-----EKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ Q+L + +Q+A+ + E ++E+ K E ++++ +L
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-----NQKVALEKQIESLSNTPVSN 1053
+E E + +K + E C+ L+ I + ++ S N K ++ +++ +S + +
Sbjct: 1150 LQENEQLMKVMKTKHE-CQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEIS---LDS 1205
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ A+++N+++ ++E++K K+
Sbjct: 1206 YNAQLVQLEAMLRNKELK--LQESEKEKE 1232
Score = 59.7 bits (138), Expect = 6e-08
Identities = 189/970 (19%), Positives = 386/970 (39%), Gaps = 75/970 (7%)
Query: 114 SLEMENLTKD-------KEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
SL+ ENLT+ K ++ L + + + +L+E+ + S IM+N E L +
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME--SQGIMKN-KEIQELEQ 1586
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
+ ++ +CL ++ + + + + K+ + + KL Q+ + + +++L
Sbjct: 1587 LLSSERQELDCLRKQYLSENE---QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1643
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+ + S+R + + E C E + H+ + D D +
Sbjct: 1644 Q--LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQD 1701
Query: 287 ENNEFE----TKAVKVMSEI--KRNLNSLSEQLINNESKKSKDHIDRYKDS---LLAVLD 337
N + E T AVK E +++ ++ E ++++ S + I S L +D
Sbjct: 1702 LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMD 1761
Query: 338 AEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ ++ + N+ L I ++ KV+ LNE +K ++ KL Q
Sbjct: 1762 FLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE----MKELDSKLHLQEVQ 1817
Query: 398 LIEKENAC----NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L+ K AC I+ K+ ++S + + L+ + T E L S L++ +
Sbjct: 1818 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN-SDLEMHADK 1876
Query: 454 DLDQDLPAH-KKITILFDA--LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXX 510
+D+ + K+ + L + ELSR I EK +E
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSR----IRSEKASIEHEALYLEADLEVVQTEK 1932
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
D E + L EEL+ + E N + +S++ AL K +EK
Sbjct: 1933 LCLEKDN-ENKQKVIVCLEEELSVV----TSERNQLRGELDTMSKKTTALDQLSEKMKEK 1987
Query: 571 MLSLSEKDNKLTELVSTING-LKEENNSLKSLN-DV--ITREK---ETQASELERSCQVI 623
L ++ + +KE+ L++L+ DV + ++K + + LE+ Q +
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2047
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK-SLLEQNLALKEQCEEKTRDCSRL 682
EL+ A + E+ L + AL+ EK RL
Sbjct: 2048 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
T E+ +++ R I +L+ +I+ D+K + KL E + ++LK + ++L
Sbjct: 2108 S---STQEEVHQLR-RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2163
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ S E NQ D E AE+E+ ++T+ +
Sbjct: 2164 QMSEE--NQELVILD-AENSKAEVET-LKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 2219
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET- 860
++ L E KL S K + +E+ Q+KE + ++ L+ + KEL++
Sbjct: 2220 QEKQGQLSELDKLLSSFKSLLEEKEQAEI-QIKEE---SKTAVEMLQNQLKELNEAVAAL 2275
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VNTDEDWANL 919
C + QE + + + E Q+ N E++R + + + + + + E A+L
Sbjct: 2276 CGD--QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL 2333
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK 979
V+ + + E+ + + +E K +++ K++ + + + R
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-AKIALEIVDKLSNQKVA 1038
E E+ EL++ ++R EL+ + L+++E++ ++KE + A+E+ L Q
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM---LQTQLKE 2449
Query: 1039 LEKQIESLSN 1048
L +++ +L N
Sbjct: 2450 LNERVAALHN 2459
Score = 58.8 bits (136), Expect = 1e-07
Identities = 198/1024 (19%), Positives = 398/1024 (38%), Gaps = 99/1024 (9%)
Query: 59 MCQSLKESSN--EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLE 116
M + L+E N E +L LEKL + D+++Q+ ++DLL + +E
Sbjct: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC-------------SQDLLKKREHHIE 582
Query: 117 MEN--LTK-DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK 173
N L+K +KE K L +L+ K K+ EL+EE S EN + E ++L+
Sbjct: 583 QLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQS 642
Query: 174 NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDS 233
L + C+ +++ + N + + +ENL S+ I L+ +
Sbjct: 643 KINHL-ETCLKTQQIKSHEYN----ERVRTLEMDRENL--SVEI------RNLHNVLDSK 689
Query: 234 NTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
+ K+ ++ + A +F+ K+ E+ NM + + G+ + E
Sbjct: 690 SVEVETQKLAYMELQQKA----------EFSDQKHQKEIE--NMCLKTSQLTGQVEDLEH 737
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
K + +EI Q ++ E + +D + SL+ D + + D +
Sbjct: 738 KLQLLSNEIMD--KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHH 795
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
+ N + + + ++ + + ++ + ++ SL L ++ + L+ Q E
Sbjct: 796 SFANIIG-EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID-------IPRDLDQDLPAHKKIT 466
+ +I + +++K E + + + ++SKL+ D + L K++
Sbjct: 855 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Query: 467 ILFDALITQ----YELSRTDYEIEK--EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+L D + T+ EL ++++ +E ++L+L + T + L +
Sbjct: 915 LLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL---SEK 577
+ +K ++ L + + + ++ + N I + I +++ +EK++ L E
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS--ELSDQYKQEKLILLQRCEET 1032
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N +L +E+N+ L+ L + T E + +ELE+ +K+ K +
Sbjct: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ----LKE---AFAKEHQEF 1085
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
L + + L + Q K+ + L+ I T E QN
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMT-DNQNNSKS-EAGGLKQEIMT---LKEEQN 1140
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+M + +QE+++L +TK +E N R+ +VK+ ES R N Q D
Sbjct: 1141 KMQKEVNDLLQENEQLMKVMKTK-HECQNLESEPIRN---SVKERESERNQCN-FKPQMD 1195
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDEN-RDLGENPKLDD 816
L + E+ D Q + + R E L D
Sbjct: 1196 L---EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQD 1252
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
+ IS + D E+ +E+ +S EL + L +T L E ++ C L+
Sbjct: 1253 MQSQEISGLKDCEI-DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311
Query: 877 KEKLSLEQQVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYDAEV 933
EK L ++++ + + T++ E K + ++D LH +V D +
Sbjct: 1312 AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGE 1371
Query: 934 EKNKR----LMKTIEELRYKKQDLKNTVTKMQKA--MEKYTKKDKEFEAKRKELEDCKAE 987
+ N++ L E Y+ L + +M A EK+ E + + ++
Sbjct: 1372 QPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSK 1431
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE--IVDKLSNQKVALEKQIES 1045
+ EL+ L E + L R Q +KE ++ LE +V LS+ V + S
Sbjct: 1432 MSELQTYVDSLKAENLVLSTNL--RNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSS 1489
Query: 1046 LSNT 1049
L ++
Sbjct: 1490 LGDS 1493
Score = 56.4 bits (130), Expect = 5e-07
Identities = 186/857 (21%), Positives = 341/857 (39%), Gaps = 91/857 (10%)
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-----I 302
EL D E E F+ +H EL + T + G N++ E A K E +
Sbjct: 1834 ELKKENSDLSEKLEYFSC--DHQELLQRVETSE-----GLNSDLEMHADKSSREDIGDNV 1886
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAV-LDAEFGTTSLDVFEILMDNIINKYQI 361
+ +S E+ ++ E++ S+ ++ A+ L+A+ + + DN NK ++
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE-NKQKV 1945
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEIS 419
+ + E+ + V + N+ EL ++++K +L+ QL EK E + Q E +H I
Sbjct: 1946 IVC-LEEELSVVTSERNQLRGELDTMSKKTTALD-QLSEKMKEKTQELESHQSECLHCIQ 2003
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
A VK++ EL + L+ + +L K K + L Q L + L T+ EL
Sbjct: 2004 VAEAE--VKEKTELLQTLSSDVSELLKDKTHLQEKL-QSLEKDSQALSL-----TKCELE 2055
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
++ KEK L V ++ L N K+L L + +
Sbjct: 2056 NQIAQLNKEKELL-------VKESESLQARLSESDYEKL----NVSKALEAALVEKGEFA 2104
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+ ++ + + L I+ L++ I +E+K L ++EK + + EN+SLK
Sbjct: 2105 LRLSSTQEEVHQ-LRRGIEKLRVRIEADEKKQLHIAEK----------LKERERENDSLK 2153
Query: 600 SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK 659
+ V E+E Q SE + ++ + + KA++ +
Sbjct: 2154 --DKVENLERELQMSEENQELVIL-----DAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-E 718
+L + L +Q +EK S L+ + + + E + + + QI+E+ K +E +
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA----EIQIKEESKTAVEMLQ 2262
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
+L EL AL D + +S + + ++ +E A LE+D + +Q +
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK-KQLCVL 2321
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
+ R E+ L+ S EV LK ++
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-------SKGEVETLKAKIE 2374
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
Q L L+ + E E LQ+ E+ + L+ S E + KEQ + Q
Sbjct: 2375 GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE-KEQEKVQ-- 2431
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ ++ A + T N V +A K + L +E L +K L +
Sbjct: 2432 MKEKSSTAMEMLQTQLKELN-ERVAALHNDQEACKAKEQNLSSQVECLELEKAQL---LQ 2487
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
+ +A Y +E+ED K +LE+ DEE ++ +E+ +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK-------KDEEISRLKNQIQDQEQLVSK 2540
Query: 1019 LK----EAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGS-AIVQNQ-QIT 1071
L E ++ E +L N V LE++I+ L + S T+ V S ++N+ ++T
Sbjct: 2541 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 1072 --DVMKENQKLKKMNAK 1086
D M +K+ KM AK
Sbjct: 2601 KMDKMSFVEKVNKMTAK 2617
Score = 44.0 bits (99), Expect = 0.003
Identities = 55/254 (21%), Positives = 106/254 (41%), Gaps = 22/254 (8%)
Query: 847 LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+KE+ KE +E Q D++C ++K QQ N+ + Q +++
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVL--QAELDKLTSVK 446
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
N E++ + ++ A K L +++EE++ + LK+ QKA E
Sbjct: 447 QQLENNLEEFK--QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS--HSEQKAREV 502
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQR---EEQCKRLKEAK 1023
EA+ K ++ C + + + K + ET L+++ +E L++ K
Sbjct: 503 C-----HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 1024 IALEIVDKLSNQKVAL----EKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
+A+ ++K + L E IE L++ A SA+ ++ + +KE +
Sbjct: 558 LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 1080 L----KKMNAKLIT 1089
L K N KL+T
Sbjct: 618 LFSCWKSENEKLLT 631
>X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein.
Length = 3259
Score = 85.4 bits (202), Expect = 1e-15
Identities = 200/1050 (19%), Positives = 437/1050 (41%), Gaps = 78/1050 (7%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L E I+ K E +S + E+++AL K Q I+E + DL+ + LEM+
Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALT-KIQTEIIEQE--DLIKALHTQLEMQAKEH 1450
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
D+ IK L L +K E+ EE+ + + + + + + K E L+
Sbjct: 1451 DERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLAR 1510
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHI---GYDNTLSKLNRSISDSNTSTRY 239
+E+L + + AQ K K+ ++ L + D +++++RS+ ++ + +
Sbjct: 1511 GTIERLTKSLADV--ESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLS-- 1566
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ +L+ L+ ED ++L ++ S+K+ K+ E+ E++ K ++
Sbjct: 1567 SSCESLKLALEGLTEDKEKLVKEIESLKS--------------SKIAESTEWQEKHKELQ 1612
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
E + L S ++NE+++ + ++ + L + +T + E + + +
Sbjct: 1613 KEYEILLQSYEN--VSNEAERIQHVVEAVRQE-KQELYGKLRSTEANKKE--TEKQLQEA 1667
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
+ +++E+ EK K + EL+ N++L + E A + + E + +
Sbjct: 1668 EQEMEEMKEKMRKFAKSKQQKILELEEENDRLRA------EVHPAGDTAKECMETLLSSN 1721
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS 479
+++ ++ + + E E L+K+ L K + ++ QDL H+ + D + Q L
Sbjct: 1722 ASMKEELERVKMEY-ETLSKKFQSLMSEKDSLSEEV-QDL-KHQ----IEDNVSKQANLE 1774
Query: 480 RTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
T+ + + E GT +++ T E+ KS + ++K + S
Sbjct: 1775 ATEKHDNQTNV-TEEGT-QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
Query: 540 VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING----LKEEN 595
DE N L I L E I L+ KN+E +L + N L +ST +G L+EE
Sbjct: 1833 -DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1891
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
+ LN I +E+ ++ ++L+ + + K +L++ + L
Sbjct: 1892 TKMNLLNQQI-QEELSRVTKLKETAEEEKD---DLEERLMNQLAELNGSIGNYCQDVTDA 1947
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
LLE + ++C + + + + KT + +EI+ + ++Q +E
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQLVKEKT-KVESEIRKEYLEKIQGAQKEPGNKSH 2006
Query: 716 EKETK--LNELTNKYEALKRD---YDAAVKDLESSREAVN--QLTTQKDL--VEGRIAEL 766
KE + L E + + L++D Y + LE + +A+ Q +QKDL + +A+
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQA 2066
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK--LDDSPKRSISV 824
+ Q E + E+ K + +
Sbjct: 2067 VEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQ 884
+ +E LKE+ + Q++LD L+ L++ L ++D++ +L++ +L+
Sbjct: 2127 LEQAEEKHLKEK-KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE---NLDS 2182
Query: 885 QVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMK-T 942
V+ L ++ ++ D ++ + W S + + + E N ++K
Sbjct: 2183 TVTQLAAFTKSMSSLQDD---RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ 2239
Query: 943 IEELRYKKQDLKNTVTKMQKAMEKY-TKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+ ++ ++LK +++++ + + +K E + ++K + + E +EL + +E
Sbjct: 2240 LRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHL 2299
Query: 1002 CETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVAT 1060
+ L + E + K LK+ L ++K QK LE I ++ Y
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359
Query: 1061 GSAIVQNQQITDVMKENQKLKKMNAKLITI 1090
+ + ++++T + E +K+ K+I++
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQ--KIISL 2387
Score = 73.3 bits (172), Expect = 4e-12
Identities = 207/1086 (19%), Positives = 436/1086 (40%), Gaps = 119/1086 (10%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE 86
L+ K KN +T N S T ++ + L+E ++NL +++ EL + +
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGEL-KMLQEEVTKMNLLNQQIQEELSRVTK 1910
Query: 87 QKSALEGKYQNLILETQTRDLLMSQIKSLE------MENLTKDKEIKN--LTDSLKTKSK 138
K E + +L + LM+Q+ L +++T D +IKN L +K K
Sbjct: 1911 LKETAEEEKDDL------EERLMNQLAELNGSIGNYCQDVT-DAQIKNELLESEMKNLKK 1963
Query: 139 KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
++EL+EE L+ E + KE L+K ++ E NK
Sbjct: 1964 CVSELEEEKQ---QLVKEKTKVESEIRKEY--LEK-----------IQGAQKEPGNKSHA 2007
Query: 199 KNICAQCKLKENLIQSLH---IGYDNTLSKLNRSISDSN-TSTRYNKICTLQSE-LDAGR 253
K + K K+ ++ L I Y +S L R++ T K + E L
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 254 EDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
E K+ + S K L+ + L + L E ++ V S++K+ L +L
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127
Query: 314 INNESK--KSKDHIDRYKDSLLAV-LDAEFGTTSLDVFEILMDNIINKYQIDLDEI---L 367
E K K K ++ D+L + E + V D + + Q +LD L
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187
Query: 368 EKYTK----VQGDLNECTSELKSVNEKLA----SLNSQLIEKENACNILRIQKER--IHE 417
+TK +Q D + E K K + S ++ KE+ C++L+ Q + IH
Sbjct: 2188 AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM 2247
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI-LFDALITQY 476
+ I ++ + ++ E + ++L + D + +++L + + T L+ + +Q
Sbjct: 2248 EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHS--SQN 2305
Query: 477 ELSRTDYEIEK------------EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE---EA 521
EL++ + E++ EK + + G + + ++ LE +A
Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQA 2365
Query: 522 HNEVKS-LHEELTKLYKSKVDENNANLNLIKIL--------SEEIDALKIAIAKNEEKML 572
E+ S LHEE+ + + + I++ +EI L+ +++ EE+ +
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425
Query: 573 SLSEKD----NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELER---SCQVIKQ 625
L E++ +K +L+ T+ +K+EN K+ D + + ++ +R Q +++
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXX-DEAKSLLEQNLALKEQCEEKTRDCSR-LE 683
+ K ++ L +N L + + D ++ +
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
I ++ E+Q + L+ + + ++ E E +L + AL+ + K++E
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605
Query: 744 SSREAVNQLTTQKDLV--EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
S + +++QLT Q + EG + + ++ ++
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCV 2665
Query: 802 GDE-NRDLGE-NPKL---------DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
E + +GE KL D R+ + ++ V++L L+ +Q+L + +
Sbjct: 2666 QKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKE 2725
Query: 851 YKELDDECETCAEYL----QERD---EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
K L + ++ + RD E+ LK++ + ++++ LKEQ + ER A
Sbjct: 2726 NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNR--ERDA 2783
Query: 904 KFADVA--VNTDED--WANLHSVVVDRMSYDAE-VEKNKRLMKTIEELR-YKK--QDLKN 955
++ A +N+ E+ ++L + +S D + + + +L + +++ + K L+N
Sbjct: 2784 LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
+ +EK+ K ++ + + AE++ LK+ L + + + LK ++Q
Sbjct: 2844 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ 2903
Query: 1016 CKRLKE 1021
++ +
Sbjct: 2904 YLQINQ 2909
Score = 72.1 bits (169), Expect = 1e-11
Identities = 188/1023 (18%), Positives = 412/1023 (40%), Gaps = 80/1023 (7%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE-------ENDTLSNLIMENVTE 160
+ +Q+K +E E + + ++ + T L KS+++ +LQE E ++L + E
Sbjct: 1307 IKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH 1366
Query: 161 SDNLNKEVDDLK------KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKE---NL 211
+++L ++++ + ++ L K +L+KL+++ E + + Q KE
Sbjct: 1367 AESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDV--SYLSGQLSEKEAALTK 1424
Query: 212 IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE 271
IQ+ I ++ + L+ + + +I LQ EL ++ +E+ E+ + K ++
Sbjct: 1425 IQTEIIEQEDLIKALHTQL-EMQAKEHDERIKQLQVELCEMKQKPEEIGEE-SRAKQQIQ 1482
Query: 272 LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS--EQLINNESKKSKDHIDRYK 329
+ E L EN + + I+R SL+ E ++ ++K+ + R
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGR-- 1540
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDN-IINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
LA+L E ++ L++N ++ L LE T+ D + E++S+
Sbjct: 1541 ---LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLK 1594
Query: 389 EKLASLNSQLIEK----ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
+ +++ EK + IL E + + + +V+ + K+ L +
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ-HVVEAVRQEKQELYGKLRST 1653
Query: 445 SKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXX 504
K + + L + +++ + + E E ++LR E A
Sbjct: 1654 EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1713
Query: 505 XXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAI 564
+++E VK +E L+K ++S + E ++ LSEE+ LK I
Sbjct: 1714 METLLSSNA---SMKEELERVKMEYETLSKKFQSLMSEKDS-------LSEEVQDLKHQI 1763
Query: 565 AKNEEKMLSL--SEKDNKLT----ELVSTINGLKEENNSLKSLNDVITREKETQASELER 618
N K +L +EK + T E +I G EE +SL E A
Sbjct: 1764 EDNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 619 SCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD 678
+ + E++ I + +++L + L Q K +
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
Query: 679 CSRLEINI-KTHEKTAEIQNRM--IMRLQKQIQED-DKLFIEKETKLNELTNKYEALKRD 734
L+ + K + +IQ + + +L++ +E+ D L +L EL +D
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943
Query: 735 Y-DAAVKD--LESS----REAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
DA +K+ LES ++ V++L +K + ++ES+IR E +
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN 2003
Query: 788 XXXXXXXXXXXXTFGDENRDLGEN----PKLDDSPKRSISVISDSEVSQLKERLLSCQQE 843
E + L ++ + + +R++ + + K+ L ++
Sbjct: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKD-LEITKEN 2062
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
L E K+ E + L + + AR+ + L L++++ + KE +++Q +
Sbjct: 2063 LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM----KQ 2118
Query: 904 KFADVAVNTDE-DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQK 962
K D+ ++ + +L + DA + L +TI E++ V ++Q+
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178
Query: 963 AMEKYTKKDKEFEAKRKELEDCKAE-LEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
++ + F L+D + ++E K+ ++ + ++ E ++ +E+ C LK+
Sbjct: 2179 NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238
Query: 1022 --AKIALEIVD-KLSNQKVALEKQI-ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN 1077
++++ + + K++ ++ +KQI ES + T V T +N+++ ++E
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG--ENKELLSQLEET 2296
Query: 1078 QKL 1080
+ L
Sbjct: 2297 RHL 2299
Score = 72.1 bits (169), Expect = 1e-11
Identities = 187/1018 (18%), Positives = 404/1018 (39%), Gaps = 103/1018 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E ++ ++L ++ + +I E+ A + + L +R + + KSL+ E
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
I+ LT SL +++ +E DT+ + E D L E+D N+ L+ C
Sbjct: 1512 TIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1571
Query: 185 LEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICT 244
L KL E + KE L++ + S + I++S +K
Sbjct: 1572 L-KLALEGLTED-----------KEKLVKEIE-------SLKSSKIAESTEWQEKHK--E 1610
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKR 304
LQ E + + + + + I++ +E +L KL + + K + E ++
Sbjct: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQE-KQELYGKLRSTEANKKETEKQLQEAEQ 1669
Query: 305 NLNSLSEQLIN-NESKKSKD-HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+ + E++ +SK+ K ++ D L A + G T+ + E L+ + + + +
Sbjct: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA-GDTAKECMETLLSSNASMKE-E 1727
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L+ + +Y + SE S++E++ L Q+ ++N ++ H+ + V
Sbjct: 1728 LERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI--EDNVSKQANLEATEKHDNQTNV 1785
Query: 423 T---IDIVKKENELKEILTKECLKLSKLKIDIPRD----LDQDLPAHKKITILFDALITQ 475
T + E E ++ L+ + + + +D +H +I I Q
Sbjct: 1786 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQ-IDQ 1844
Query: 476 YELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK- 534
+ E EK+K + + T + + E+K L EE+TK
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLE----------NEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 535 -LYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLK 592
L ++ E + + +K EE D L EE+++ N+L EL +I
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDL-------EERLM------NQLAELNGSIGNYC 1941
Query: 593 EENNSLKSLNDVITREKETQ---ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
++ + N+++ E + SELE Q + + E K++++I
Sbjct: 1942 QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK---EKTKVESEIRKEYLEKIQGAQ 1998
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ- 708
AK L E +++ ++ +DC R + I E+T + + QK ++
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 709 --EDDKLFIEKETKLNELTNKYEALKRDYDAAV-----------KDLESSREAVNQLTTQ 755
E+ +E K ++ L D + K+L+S++E+V Q
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
Query: 756 KDL-VEGRIAEL-ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
KD +E R+ + E ++ ++ T +++++ + +
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
DS ++ + S S +R + +D+ K+ ++ D ++ E ++ +++ C+
Sbjct: 2179 NLDSTVTQLAAFTKSMSSLQDDR----DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 874 RLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK + + + LK I R + + A V + + ++ + ++
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD--TLQGENKELLSQ 2292
Query: 933 VEKNKRL----MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E+ + L + +L + + LK+ +T + ++EK ++ E ++ E A++
Sbjct: 2293 LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE---ADI 2349
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ K Y++L+ + + E + E+ +KE K I+ LS ++ A++ I L
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEI-NMKEQK----IISLLSGKEEAIQVAIAEL 2402
Score = 70.1 bits (164), Expect = 4e-11
Identities = 188/1002 (18%), Positives = 398/1002 (39%), Gaps = 69/1002 (6%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINEL 143
+KE++ ++ ++ I + L +K+LE K+++ ++L + +
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 144 QEENDTLSNLIMENVTES-----DNLN--KEVDDLKKNNEC-LTQKCIDLEKLVNESENK 195
Q E + L+ + +E+ DNL KE+ K++ + + QK DLE+ + ++E K
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS--DSNTSTRYNKICTLQSELDAGR 253
+ Q KL + +H+ + T+ ++ +++ D + + ++L A
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHL--EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2191
Query: 254 EDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
+ L +D + + + E + + K E + V+ + R ++ E+L
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSK-EEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV 373
N S+ +H + +S A + + D + ++++ L+E Y
Sbjct: 2251 KINISRL--EHDKQIWESK-AQTEVQLQQKVCDTLQGENKELLSQ----LEETRHLYHSS 2303
Query: 374 QGDLNECTSELKSVNEKLASLNSQLIE-KENACNILRIQKERIHEISSAVTIDIVKKENE 432
Q +L + SELKS+ ++L L++ L + KE N+ I +++ +I ++ + E +
Sbjct: 2304 QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS-KFSYEQLETD 2362
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKK--ITILFDALITQY-----ELSRTDYEI 485
L+ ++E +I++ L + K+ I + L Q+ EL +
Sbjct: 2363 LQA--SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2420
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
E+E + LE KAV T+++ + + K+ + K S ++ +
Sbjct: 2421 EEENIVLEEENKKAVDKTNQLMET-----LKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE----LVSTINGLKEENNSL--- 598
+ + L E L I + K ++ + + ++NKL E L S ++ L EN L
Sbjct: 2476 IVGDYQQLEER--HLSIILEK-DQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2532
Query: 599 -----KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ LN VIT + Q LE Q K+ + K++ +
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2592
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+E + L ++ +LK + TR + L E + + +++ + RL
Sbjct: 2593 LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQ 2652
Query: 712 KLFIEKETKLNELTNKYEALKRD---YDAAVKDLESSREAVNQLTTQKDLVEGRIAELES 768
K E E +L + + EA K+ D K+L+ + + + E R+AEL
Sbjct: 2653 KRIAELEEEL--VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELAR 2710
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
D+ E + + +RD N +LD+ KR S
Sbjct: 2711 DL-VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA-NEELDEL-KRKYDA-SLK 2766
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
E++QLKE+ L ++ L E ++ E +L++ ++Q ++ L L Q+ +
Sbjct: 2767 ELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
Q+++ A + D W L + ++ L+
Sbjct: 2827 SYNQVQSFSKA-----MASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
L+N ++ K ++ ++ + + EL KA+L+E + + K E +
Sbjct: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQK--VALEKQIESLSN 1048
+ + +L+ K + EI ++ ++ +A+ + + LS+
Sbjct: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH 2983
Score = 67.3 bits (157), Expect = 3e-10
Identities = 184/1017 (18%), Positives = 397/1017 (39%), Gaps = 78/1017 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ-TRDLLMSQIKSLEMEN 119
++LKE N ++ E ++ + E S L+ Y + Q +++ L + L+ EN
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE--- 176
+ ++++ + K ++++ L+EE L + + + S+ EV++ K+N E
Sbjct: 989 EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
Query: 177 -CLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK---ENLIQSLHIGYDNTLSKLNRSI 230
C+T KC ++E + + SE ++ ++I + K E Q+L + TL I
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQI 1108
Query: 231 SDSNTSTRYNKIC---TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKL-- 285
N+ + S DA D L ++ I + +L+EK+
Sbjct: 1109 DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA 1168
Query: 286 --GENNEFETKAVKVMSEIKRNLNSL--SEQLINNESKKSKDHIDRYKDSLLAVLDAEFG 341
E + + K + ++ K L E+ + E K+ KD +R L +F
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNR--------LQEQFD 1220
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASL----NSQ 397
S + I + + + QI + E ++ D E S + E L ++Q
Sbjct: 1221 EQSKENENI--GDQLRQLQIQVRESIDGKLP-STDQQESCSSTPGLEEPLFKATEQHHTQ 1277
Query: 398 LIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC---LKLSKLKIDIPRD 454
+ + N C E + ++ +K +LKEI ++ LK+S ++ +
Sbjct: 1278 PVLESNLCPDWPSHSEDASALQGGTSVAQIKA--QLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
++ ++I I + + E+ E L+ + +++
Sbjct: 1336 SEEVFQLQEQIN-KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ--- 1391
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L+E + E+++ L ++ E A L KI +E I+ + A + + +
Sbjct: 1392 -PKLDELQKLISKKEEDVSYL-SGQLSEKEAALT--KIQTEIIEQEDLIKALHTQLEMQA 1447
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITR-EKETQASELERSCQVIKQNGF---EL 630
E D ++ +L + +K++ + + + +++ QA+ + R + +K+N EL
Sbjct: 1448 KEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK-EALKENKSLQEEL 1506
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+ I E ++L + L+E+ ++ + R + ++
Sbjct: 1507 SLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLS 1566
Query: 691 KTAEIQNRMIMRL----QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
+ E + L +K ++E + L K + E K++ L+++Y+ ++ E+
Sbjct: 1567 SSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVS 1626
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG-DEN 805
++ + V EL +R+ + F +
Sbjct: 1627 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ 1686
Query: 806 RDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
+ + E + +D + + D+ + E LLS + + ER K E ET ++
Sbjct: 1687 QKILELEEENDRLRAEVHPAGDT-AKECMETLLSSNASMKEELERVKM---EYETLSKKF 1742
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD 925
Q L EK SL ++V +LK QI + V +QA A ++ N+
Sbjct: 1743 QS-------LMSEKDSLSEEVQDLKHQI--EDNVSKQANLE--ATEKHDNQTNVTEEGTQ 1791
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
+ + E E++ M T K+ + K + + + + + +L++
Sbjct: 1792 SIPGETE-EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ-QIDQLKERI 1849
Query: 986 AELEELKQRYKE----LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
A LEE KQ+ KE L+ E T + ++ + K L+E + ++++ ++++
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1906
Score = 67.3 bits (157), Expect = 3e-10
Identities = 215/1069 (20%), Positives = 426/1069 (39%), Gaps = 112/1069 (10%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN 119
C+SLK + + EKL E+ +K K A ++Q E Q ++ Q EN
Sbjct: 1569 CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ----SYEN 1624
Query: 120 LTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV-DDLKKNNEC 177
++ + E I+++ ++++ + +++ + + + E++ +E+ + ++K +
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1684
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
QK ++LE+ + ++ P A+ + E L+ S + L ++ + S
Sbjct: 1685 KQQKILELEEENDRLRAEVHPAGDTAK-ECMETLLSS-NASMKEELERV--KMEYETLSK 1740
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL-----HEPNMTMDLDEKL-GENNEF 291
++ + + + L +D K ED S + +LE ++ N+T + + + GE E
Sbjct: 1741 KFQSLMSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
Query: 292 ETKAVKVMSEIKRNLNSL-SEQLINNESKKSKDHIDRYKDSL------LAVLD------A 338
++ ++ ++ S S ++ S D I+ Y + +A L+
Sbjct: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK 1860
Query: 339 EFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK-------VQGDLNECTSELKSVNEKL 391
EF T + L+ I K +L + E+ TK +Q +L+ T ++ E+
Sbjct: 1861 EFSQTLENEKNTLLSQISTK-DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEK 1919
Query: 392 ASLNSQLIEK--------ENAC-NILRIQ-KERIHEISSAVTIDIVKKENELKEILTKEC 441
L +L+ + N C ++ Q K + E V + E K+ L KE
Sbjct: 1920 DDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEK 1979
Query: 442 LKL-SKLKIDIPRDLD--QDLPAHKKITILFDALI--TQYELSRTDYEI--EKEKLRLET 494
K+ S+++ + + Q P +K L+ Q E+ + + +EK+
Sbjct: 1980 TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALE 2039
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILS 554
T KA+ + L +A K EL +K +D+ + ++L+
Sbjct: 2040 RTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS-FKVLLDDTQS--EAARVLA 2096
Query: 555 EEIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTI--NGLKEENNSLKSLNDVITREK-- 609
+ + LK + N+E + S + +KD L + LKE+ N + L D + REK
Sbjct: 2097 DNL-KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL-DALRREKVH 2154
Query: 610 -ETQASE----LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS---- 660
E E L + + ++Q LD + DEAK
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214
Query: 661 -------------LLEQNLA-LKEQCEEKTRDCSRLEINIKTHEKTAEI-QNRMIMRLQK 705
L E N + LK+Q + + L+INI E +I +++ +Q
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 706 QIQEDDKLFIEKE---TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
Q + D L E + ++L E + Y + + + +L+S ++ + L+ + + +
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQ 2334
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-DSPKRS 821
LE IR +Q A + + E ++ E + S K
Sbjct: 2335 KGNLEGIIR-QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEE 2393
Query: 822 ISVISDSEVSQLKER-LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
++ +E+ Q ++ + + L +E L++E + + + E +KKE +
Sbjct: 2394 AIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENI 2453
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV---DRMSYDAEVEKNK 937
QQ + L +++ ++ D V + H ++ D++ +A E NK
Sbjct: 2454 ---QQKAQLDSFVKSMSSLQND---RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
L + I LR DL + K+ + +Y ++D K+ + K LE Q+ KE
Sbjct: 2508 -LKEEIRGLRSHMDDLNSENAKLDAELIQY-REDLNQVITIKDSQQ-KQLLEVQLQQNKE 2564
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
L+ + E LK+ EE + L+ + AL+ +K L K+IESL
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSFNALQ------EEKQDLSKEIESL 2607
Score = 59.7 bits (138), Expect = 6e-08
Identities = 191/1006 (18%), Positives = 386/1006 (38%), Gaps = 90/1006 (8%)
Query: 91 LEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL 150
LE ++L+ Q DLL ++ + E N ++++ + T + +EE+ L
Sbjct: 261 LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKIL 320
Query: 151 SNLIMENVTES----DNLNKEVDDLKKNNECLTQKCIDLEKLVN--ESENKIGPKNICAQ 204
+ V E NL +E+ L + E Q +LE + E ++K + +
Sbjct: 321 LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
+ Q L D + ++ + D N T+Q D ++ KE+ +
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQA-VQSAQTIQQLEDQLQQKSKEISQFLN 439
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNE--FETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
+ L+ HE + E + E + + N L+++ +
Sbjct: 440 RLP--LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 497
Query: 323 DHIDRYKDSLLAVLDAE--FGTTSLDVFEILMDNIINKYQIDLDE----ILEK-YTKVQG 375
+ S + +L+A+ G +V EI + +I NK +E +LE +++
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK 557
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE 435
+L+ E+K E++A L QL K +E HE+ + ++ E +
Sbjct: 558 ELSVLLLEMKEAQEEIAFLKLQLQGKR--------AEEADHEVLDQKEMKQMEGEG-IAP 608
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG 495
I K L+ + + + + LPA +K + T+++ SRT EI +E
Sbjct: 609 IKMKVFLEDTGQDFPLMPNEESSLPAVEK-----EQASTEHQ-SRTSEEISLNDAGVELK 662
Query: 496 TAKAVXXXXXXXXXXXXXXF-DTLEEAHNEVKSLH---EELTKLYKSKVDENN---ANLN 548
+ K D LE +++ L + ++Y+ +DE +NLN
Sbjct: 663 STKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN 722
Query: 549 -LIKILSEEID---ALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL-----------KE 593
LI+ + D + A+++ +++LS ++ + +TEL + + L +
Sbjct: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRL 782
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ S + ++++T + + + E + I+ ELD ++
Sbjct: 783 DYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQN 842
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK- 712
E E+ + + EE ++ S+ E+ I ++ + R + LQ+ I+E D+
Sbjct: 843 KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902
Query: 713 ------LFIEKETKLNE-----------LTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
EK +LNE L + L R +A + +E E + L
Sbjct: 903 VTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQN 962
Query: 756 KDLVE--GRIA--ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
D + G+I+ EL+ + + +E +L +
Sbjct: 963 YDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 1022
Query: 812 PK--LDDSPKRSISVISDSEVSQLKERLLS--CQQELDDLKERYKELDDECETCAEYLQE 867
K + S V D E + E+ ++ CQ+ LK+ E + E + + L+E
Sbjct: 1023 SKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1082
Query: 868 R---DEQCARLKKEKLSLEQ----QVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ +EQ L K+ Q Q+ L+ +I Q + ++ ++ + + A +
Sbjct: 1083 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
Query: 921 SVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-R 978
VV E K L + I L +K+ L+ + + + + KK +E E R
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
+EL+ K + L++++ E +E E + L+Q + Q + + K+
Sbjct: 1203 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL 1248
Score = 57.6 bits (133), Expect = 2e-07
Identities = 217/1101 (19%), Positives = 432/1101 (39%), Gaps = 103/1101 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQ-IKSLEMENLT 121
++E ++ I L L+K EL + AL+ + L+ + + + +Q I+ LE +
Sbjct: 374 MEEKTSHI-LSLQKTGQEL---QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQ 429
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESD--NLNKEVDDLKKNNECLT 179
K KEI + L + + Q + N + VTE + +L K V +L+ L
Sbjct: 430 KSKEISQFLNRLPLQQHETAS-QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALL 488
Query: 180 QKCIDLEKLVNESENKIGPKNIC-AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
I+LE+L E+E + AQ + E + I + +K + S +S
Sbjct: 489 LSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL 548
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLE---LHEPNMTMDLDEKLGENNEFETKA 295
N EL + KE E+ +K L+ E + + LD+K + E E A
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV-LDQKEMKQMEGEGIA 607
Query: 296 VKVMSEIKRNLNSLSEQLINNES--------KKSKDHIDRYKDSL-LAVLDAEFGTTSLD 346
M + + N ES + S +H R + + L E +T D
Sbjct: 608 PIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQD 667
Query: 347 VFEIL--MDNIINKYQIDLDEILEKYTKVQGDLNECTSEL-KSVNEKLASLNS--QLIE- 400
+ L + +I +Q +L+ + + +++ + ++ K+++EK +++ QLIE
Sbjct: 668 GDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE 727
Query: 401 -KENACN----ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
K+NA N + +ER +S + +V EL+ + + + L++ + D
Sbjct: 728 FKKNADNNSSAFTALSEERDQLLSQVKELSMV---TELRAQVKQLEMNLAEAERQRRLDY 784
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR-LETGTAKAVXXXXXXXXXXXXXX 514
+ +T +L + + E+ + +L ++ ++
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
Query: 515 FDTLEEAHN--EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ LE A + S EEL++ K E L+ +++ L+ I + ++++
Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904
Query: 573 SLS-EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV---IKQNGF 628
+S K+ +L L E +LK ++++R +E + ++E +V +KQN
Sbjct: 905 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
Query: 629 EL--------DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS 680
E+ ++++ + + K LL++ L+E+ +D S
Sbjct: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN-LKDES 1023
Query: 681 RLEINIKTHEK--------TAEIQNRMIMRLQKQIQEDDKLFI-EKETKLNELTNKYE-- 729
+ EI + E+ E + + ++I+ K I EKE +L + E
Sbjct: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1083
Query: 730 -ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
A + + A VK + + + T Q DL++ I+E ++ I+ T+
Sbjct: 1084 LAAEEQFQALVKQMN---QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 789 XXXXXXXXXXXTFGDEN-------RDLGENPKLDDSPKRSISVISDSEV----SQLKERL 837
T E+ + L + + K+ ++ + +Q KER
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 838 L--SCQQELDD---LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
L +Q+ DD L+E++ E E E + L++ Q KL Q +
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260
Query: 893 IRTQQPV----ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
++P+ E+ + N DW + HS + V + K +K IE
Sbjct: 1261 PGLEEPLFKATEQHHTQPVLESNLCPDWPS-HSEDASALQGGTSVAQIKAQLKEIEA--- 1316
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
+K +L+ K+ + TKK +E ++++ E+E LK E + E+ +
Sbjct: 1317 EKVELE---LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373
Query: 1009 LKQREEQ---CKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
L+ + Q + L+E + L+ + KL ++K E+ + LS + I+
Sbjct: 1374 LESSQLQIAGLEHLRELQPKLDELQKLISKK---EEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 1066 QNQQITDVMKENQKLKKMNAK 1086
+ + D++K +M AK
Sbjct: 1431 EQE---DLIKALHTQLEMQAK 1448
Score = 55.6 bits (128), Expect = 9e-07
Identities = 179/1029 (17%), Positives = 419/1029 (40%), Gaps = 88/1029 (8%)
Query: 103 QTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESD 162
Q D L +I LE E K+KE ++ K+ ++++ ++ L ++ E VT+ +
Sbjct: 1840 QQIDQLKERIAGLEEEK-QKNKEFSQTLEN--EKNTLLSQISTKDGELK-MLQEEVTKMN 1895
Query: 163 NLNKEVDD----LKKNNECLTQKCIDLE-KLVNESENKIGP-KNIC---AQCKLKENLIQ 213
LN+++ + + K E ++ DLE +L+N+ G N C ++K L++
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE 1955
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
S +S+L + + ++SE+ R++ E + + + H
Sbjct: 1956 SEMKNLKKCVSEL-----EEEKQQLVKEKTKVESEI---RKEYLEKIQGAQKEPGN-KSH 2006
Query: 274 EPNMTMDLDEKLGENNEFETKAVKV---MSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ L EK E + + ++ +S ++R + +L + + ES+K ++ K+
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQKD---LEITKE 2061
Query: 331 SLL-AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+L AV + L F++L+D+ ++ L + L+ ++Q + S++K +E
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121
Query: 390 KLASLNSQ-----LIEKENA---CNILRIQKERIHEISSAVTIDIVKKENELKEI----- 436
L Q L EK+N + LR +K + E + + + KK+ E++++
Sbjct: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
Query: 437 -----LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR 491
L +S L+ D R +D+ +K + + + L + + K++LR
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR 2241
Query: 492 LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK 551
+ +++ +A EV+ L +++ + EN L+ ++
Sbjct: 2242 -QMSIHMEELKINISRLEHDKQIWES--KAQTEVQ-LQQKVCDTLQG---ENKELLSQLE 2294
Query: 552 ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKET 611
+ + +AK E ++ SL ++ LT+L +++ KE+ +L+ + + +E +
Sbjct: 2295 ETRHLYHSSQNELAKLESELKSLKDQ---LTDLSNSLEKCKEQKGNLEGI--IRQQEADI 2349
Query: 612 QASELE-RSCQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK 669
Q S+ + Q EL ++ +I M A + L Q +
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 670 -EQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
++ E I ++ K A + +M K I++++ I+++ +L+
Sbjct: 2410 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN---IQQKAQLDSFVKSM 2466
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
+L+ D D V D + E + +KD + A + ++ E
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE------IRGLRSHMD 2520
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS-------DSEVSQLKERLLSCQ 841
DL + + DS ++ + + +++ ++L+E+L +
Sbjct: 2521 DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVER 901
+ +DL+ + L +E + ++ ++ ++L ++ +L+++ + + + E
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 902 QAKFADVAVNTDEDWANLHS--VVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ + + ++ + A L V V + + E +L K ++ L + ++N
Sbjct: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2700
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++ + + + E E K + L Q + + ++ + ++ KR
Sbjct: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQ 1078
+A +L+ + +L Q + ++ LS T S NST + NQQ+ + +++
Sbjct: 2761 YDA--SLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL---LSKDE 2815
Query: 1079 KLKKMNAKL 1087
+L ++++L
Sbjct: 2816 QLLHLSSQL 2824
Score = 43.2 bits (97), Expect = 0.005
Identities = 58/258 (22%), Positives = 111/258 (43%), Gaps = 20/258 (7%)
Query: 802 GDENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
GD++ D LD + + S +++ ++ERL +Q + +LK+ ++ D + +
Sbjct: 18 GDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQ 77
Query: 861 CAEYLQ-ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
E LQ ER ++KK KL + ++++L + I E +A+ V + L
Sbjct: 78 KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIE-----EMKAQGGTVLPTEPQSEEQL 132
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKA-----MEKYTKKDKEF 974
+ E+EK K ++ EEL Q Q A ME++ ++
Sbjct: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
Query: 975 EAKRKELEDCKAELEE------LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ K + + +A+L + +Q +E D ET + +E + + +A + E+
Sbjct: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFET--QVRLHEDELLQLVTQADVETEM 250
Query: 1029 VDKLSNQKVALEKQIESL 1046
KL + LE+ ESL
Sbjct: 251 QQKLRVLQRKLEEHEESL 268
Score = 38.3 bits (85), Expect = 0.15
Identities = 96/539 (17%), Positives = 215/539 (39%), Gaps = 55/539 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANL----NLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
+V++ ++ ++ + K++E+ +L ++ +L +E+ A A +N+ L + +
Sbjct: 245 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTA---AEQRNQILSQQLQQMEA 301
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILM 639
+ L +T+ +EE+ L ++ E++ L+ + + + + +A++
Sbjct: 302 EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL-- 359
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
E + L+L++ +E C L+ + K + +N
Sbjct: 360 ----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK---DQNSKLLQDKNEQ 412
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL- 758
++ + IQ+ + +K ++++ N+ L++ A+ Q T++++
Sbjct: 413 AVQSAQTIQQLEDQLQQKSKEISQFLNRLP-LQQHETASQTSFPDVYNEGTQAVTEENIA 471
Query: 759 -VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT--FGDENRDLGENPKLD 815
++ R+ ELE++ +++ G+ +R++ E +D
Sbjct: 472 SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVD 531
Query: 816 DSPKRSIS-------VISDS------EVSQLKERLLSCQQELDDLK-----ERYKELDDE 857
+ KRS S V+ ++ E+S L + Q+E+ LK +R +E D E
Sbjct: 532 IANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHE 591
Query: 858 CETCAEYLQERDEQCARLKKEKLSLE---QQVSNLKEQIRTQQPVERQAKFADVAVNTDE 914
E Q E A +K K+ LE Q + + + VE++ + T E
Sbjct: 592 VLDQKEMKQMEGEGIAPIKM-KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSE 650
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTI-----EELRYKKQDLKNTVTKMQKAMEKYTK 969
+ +L+ V+ S + +K+ + I +EL K + KA E Y
Sbjct: 651 E-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIY-- 707
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+K + K KE+ + +EE K K D ++R++ ++KE + E+
Sbjct: 708 -EKNLDEKAKEISNLNQLIEEFK---KNADNNSSAFTALSEERDQLLSQVKELSMVTEL 762
Score = 37.5 bits (83), Expect = 0.26
Identities = 86/454 (18%), Positives = 179/454 (39%), Gaps = 39/454 (8%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
A N+ K L L K KLT L I +K + ++ + E Q S+ ++S
Sbjct: 89 ADNKIKKLKLHAKA-KLTSLNKYIEEMKAQGGTVLPTEP----QSEEQLSKHDKSST--- 140
Query: 625 QNGFELDKMKADIL----MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS 680
+ E++K+K + + ++ + +E+ + +K+Q +EK S
Sbjct: 141 EEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIS 200
Query: 681 RLEINI---KTHEKTAEIQNRMIMRLQKQIQ--EDDKLFIEKETKLN-ELTNKYEALKRD 734
L+ + + + ++ R + Q++ ED+ L + + + E+ K L+R
Sbjct: 201 TLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK 260
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ + L + V+ L Q++L AE + I ++Q +
Sbjct: 261 LEEHEESLVGRAQVVDLL--QQELTA---AEQRNQILSQQLQQMEAEHNTLRNTVE---- 311
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
T +E++ L E +L+ + ++ E+ L E+ Q +L+ RY L
Sbjct: 312 -----TEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSAL 366
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTD 913
+ + + AE ++E+ L+K L+ LK+Q + Q QA + +
Sbjct: 367 EQKHK--AE-MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL 423
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQD---LKNTVTKMQKAMEKYTKK 970
ED S + + +++++ +T Y + + + +QK + + +
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483
Query: 971 DKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
ELE+ KAE E+L + L+ + T
Sbjct: 484 KGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
>X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein.
Length = 2349
Score = 85.4 bits (202), Expect = 1e-15
Identities = 208/1054 (19%), Positives = 424/1054 (40%), Gaps = 76/1054 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS-RTDYEIEKE 488
E ++K++ + + L +L+ + +D +I+Q+ +S R E++++
Sbjct: 490 EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
RL + + E +++S EL +L KS+ + +
Sbjct: 550 NQRLLVALRE---LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ----MQ 602
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST-INGLKEENNSLKSLNDVITR 607
L+ + + D +I +++ + L L ST + S + VI
Sbjct: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
Query: 608 EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
+ +A + Q I +N ++ +K + + + K + + A
Sbjct: 663 TEAIEAKAALKQLQEIFEN-YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFA 721
Query: 668 ------LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
L++ E R+ + L + T + Q ++I + + ++ ++ E +
Sbjct: 722 SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 722 NELTNKYEALKRDYDAAVKDLES---SREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
L + E LK + ES + N L T ++G + E++ + ++ +
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
N D+ +L D+ KR + ++ ++ KE L
Sbjct: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDV----QLLDT-KRQLDTETNLHLN-TKELLK 895
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR-TQQ 897
+ Q+E+ LK+ ++ +Q + R K + S ++ V +L Q+R T++
Sbjct: 896 NAQKEIATLKQHLSNME---------VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
V + + + E + + + + + ++ + +V + R K IE + + + +
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR--KNIEVRLKESAEFQTQL 1004
Query: 958 TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC---AEYLKQREE 1014
K K ME +K + + KR+ +E + +L ELK+ + E + A E+
Sbjct: 1005 EK--KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
Query: 1015 QCKR--LKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q +R ++AKIA+E +K + + +E+L
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Score = 73.3 bits (172), Expect = 4e-12
Identities = 206/1066 (19%), Positives = 419/1066 (39%), Gaps = 73/1066 (6%)
Query: 54 TISCKMCQSLKESSNEINLKLE-KLSGELFDIKEQKSALEGKYQNLILETQTRDL--LMS 110
T+S + ES+ I K K E+F+ +++ A K QN LE + L S
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRS 709
Query: 111 QIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
Q + + K + L D+++ ++I L E N L+ + + +N D
Sbjct: 710 QNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK---QEQIINTMTQD 766
Query: 171 LKKNNECLTQKCIDLEKLVNESEN-KIGPKNICAQCK--LKENLIQSLHIGYDNTLSKLN 227
L+ NE L + E L E E K+ + Q + L E Q+L + T+ +
Sbjct: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL 826
Query: 228 RSISDSNTSTRYN-KICTLQSELDAGREDCKELCEDFTSIKNHLELH--EPNMTMDLDEK 284
S++ T R + +I L+ E+ ++ + E ++ +L++ + +D +
Sbjct: 827 ER-SETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 285 LGENN-EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
L N E A K ++ +K++L+++ Q+ + S+++ K+ + ++ T
Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 344 SL--DVFEILMDNIIN--KYQI---DLDEILEKYTKVQGDLNECTS-ELKSVNEKLASLN 395
D+ E L + N +YQ L+E L K +V ++ + LK E L
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE 1005
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+L+E E L+ K R E S + +KK + +E L+ + + +
Sbjct: 1006 KKLMEVEKEKQELQDDKRRAIE-SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXF 515
+D KI + +YE + + E L+ AK
Sbjct: 1065 RRDCQEQAKIAVEAQ---NKYERELMLHAADVEALQ----AAKEQVSKMASVRQHLEETT 1117
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI----KILSEEIDAL--KIAIAKNEE 569
E E K+ EE ++ K +V + + ++L ++I+ L K+ + E
Sbjct: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEG 1177
Query: 570 KM----LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK---ETQASELERSCQV 622
+SLSE+ +++ + ++ E ++ +V E + LER Q
Sbjct: 1178 VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
Query: 623 IKQN-GFELDKMK--ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ + E +K++ A + + K L E+ L++ ++
Sbjct: 1238 LEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKV 1297
Query: 680 SRLEINI-KTHEKTAEIQNR--MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD 736
+LE++I E AE+ + M+ +K ++ED K + + L ++ + + +Y
Sbjct: 1298 RKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL--VSQQKDPDTEEYR 1355
Query: 737 AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
+ + E + + QLT + ++ IA + + Q
Sbjct: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK 1415
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
+ D+ E K K+ I +Q +E L + Q ++ + +
Sbjct: 1416 DLDA---KIIDIQEKVKTITQVKK----IGRRYKTQYEE-LKAQQDKVMETSAQSSGDHQ 1467
Query: 857 ECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
E + +QE E + + + SLE QV NL++ + ++ R + + V +
Sbjct: 1468 EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ--EQTVQLQSEL 1525
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
+ L + DR + + ++ + ++ + E+ R K+ + + ++ TK+++E +
Sbjct: 1526 SRLRQDLQDRTTQEEQLRQ--QITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQ--REEQCKRLKEAKIALEIVDKLSN 1034
+ L+ K +EL R L + E L++ RE Q + L++ E +K+
Sbjct: 1584 RNGALDQQK---DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPE 1640
Query: 1035 QKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKL 1080
Q ++QI +L TP S +T N + T V+ K+
Sbjct: 1641 Q----QRQI-TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKV 1681
Score = 71.7 bits (168), Expect = 1e-11
Identities = 208/1075 (19%), Positives = 433/1075 (40%), Gaps = 92/1075 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
K A L+ + + A + +I K + +++ + ++ L E L E +++K
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGM-KLTELYNAYVETQDQLLLEKL--ENKRINKY 422
Query: 448 KIDIPRDLDQDLPAHKKITILFD-ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXX 506
+I ++++ P K+ ++ A LS + KE RL+ T KA
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 507 XXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV--DENNANLNLIKILSEEIDALKIAI 564
+++ +++ L EL + + V DE ++ ++ S E+ + +
Sbjct: 483 ERDNRRMEIQ-VKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS--SSEVISQHLVS 539
Query: 565 AKNEEKMLSLSEK-DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
+N E++ +++ L EL T +EE + S + + E+ +ELE Q+
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETRE--REEQETTSSKITELQLKLESALTELE---QLR 594
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLALKEQCEEKTRDCSRL 682
K ++ + + + A SL + +LA + T
Sbjct: 595 KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK-RPSTSQTVST 653
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ E T I+ + + KQ+QE + + +++ + ++ N E L++ V DL
Sbjct: 654 PAPVPVIESTEAIEAKAAL---KQLQEIFENYKKEKAENEKIQN--EQLEK-LQEQVTDL 707
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
S +++TQ D R L+ ++ + T
Sbjct: 708 RSQN---TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE-LDDECETC 861
+ R G N KL + R+ ++ + E+ +L E LS Q+E ++R + L +T
Sbjct: 765 QDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822
Query: 862 AEYLQERD-EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
L+ + E RL + LE ++S+LK+++ + VE++ NL
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENE--VEQRHTLT----------RNLD 870
Query: 921 SVVVD-RMSYDAEVE---KNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
++D + D E K L+K + E+ KQ L N ++Q A + + K
Sbjct: 871 VQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSN--MEVQVASQSSQRTGKGQP 928
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQ 1035
+ +++++D ++L + +++ +L E +T ++Q + L+E+ + V + +
Sbjct: 929 SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITI 1090
+ + + + T + M V +Q+ + + Q+L ++ L ++
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSV 1043
Score = 68.1 bits (159), Expect = 2e-10
Identities = 169/908 (18%), Positives = 363/908 (39%), Gaps = 65/908 (7%)
Query: 24 RNQ-LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
RNQ L K + II T + ++ + + ++ ++LK+ + L +LS +
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANE-KLAVAEVRAENLKKEKEMLKLSEVRLSQQRE 803
Query: 83 DIKEQKSALEGKYQNL-----ILE---TQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
+ ++ NL ILE T+T+ L SQI+ LE E K+++N +
Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRH 863
Query: 135 TKSKKIN----ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVN 190
T ++ ++ + + + DT +NL + N KE+ LK++ L+ + + +
Sbjct: 864 TLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH---LSNMEVQVASQSS 920
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
+ K P N L L Q+ D K S SN + +L+ L+
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVND---LKERLKTSTSNVEQYQAMVTSLEESLN 977
Query: 251 AGREDCKELCEDF-TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
++ +E+ ++ +K E + + L E E E + + + +++ L+ L
Sbjct: 978 KEKQVTEEVRKNIEVRLKESAEF-QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 310 SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ L ++ + ++ + R +L A + +I ++ NKY+ +L
Sbjct: 1037 KKTL-SSVQNEVQEALQRASTALSNEQQAR--RDCQEQAKIAVE-AQNKYERELMLHAAD 1092
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI--HEISSAV-TIDI 426
+Q E S++ SV + L + + C ++ER+ E+S V +
Sbjct: 1093 VEALQA-AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 427 VKKENELK----EILTKECLKLSKLKIDIPRD--LDQDLPAHKKITILFDALITQYELSR 480
++K+N L E L+ + + K + P + L ++ + ++I + + + E++
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 481 TDYEI-EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL--HEELTKLYK 537
T +E+ + E LR + V E+ K++ HEEL K +
Sbjct: 1212 TRFEVAQVESLRYR----QRVELLERELQELEDSLNAEREKVQVTAKTMAQHEELMKKTE 1267
Query: 538 SK--VDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING---- 590
+ V E N L K L +++ ++ + K E +L L E + +L+E +
Sbjct: 1268 TMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL 1327
Query: 591 LKEENNSLKSLND-VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
L+E+ K+ N +++++K+ E + + + + ++ +I
Sbjct: 1328 LEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+ +SL E ++ + E +D I+I+ KT ++ R + Q +E
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
++ K+ E + + ++ +V++++ +E +NQ T+ +E ++ L+
Sbjct: 1448 ----LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKT 1503
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + L + + R V + S+
Sbjct: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSK 1563
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
++ L +E ++LK+R LD Q++DE R+ K E ++S L
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALD----------QQKDELDVRITALKSQYEGRISRL 1613
Query: 890 KEQIRTQQ 897
+ ++R Q
Sbjct: 1614 ERELREHQ 1621
Score = 60.1 bits (139), Expect = 4e-08
Identities = 191/1050 (18%), Positives = 415/1050 (39%), Gaps = 104/1050 (9%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
E+ LKLE EL +++ + ++Q ++++ R M +I + + +
Sbjct: 578 ELQLKLESALTELEQLRKSR-----QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
Query: 129 LTD-SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L D SL + K+ + Q + ++E+ TE+ + L++ E ++ + EK
Sbjct: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIES-TEAIEAKAALKQLQEIFENYKKEKAENEK 691
Query: 188 LVNESENKIGPK---------NICAQCKL---KENLIQSLHIGYDNTLSKLNRSISDSNT 235
+ NE K+ + I Q + ++Q GY ++ L+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 236 STRYNK--ICTLQSELDAGRED---CKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN-- 288
+T+ + I T+ +L E + E+ K L+L E ++ + L E
Sbjct: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
Query: 289 -NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLD 346
N T + ++R+ + ++Q ++++ +K + I K L ++ T +LD
Sbjct: 812 QNLLLTNLQTIQGILERS-ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
Query: 347 VFEILMDNIINKYQIDLDEILEKYTK-----VQGDLNECTSELKSVNEKLASLNSQLIEK 401
V L+D K Q+D + L TK Q ++ L ++ ++AS +SQ K
Sbjct: 871 VQ--LLDT---KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
N KE + ++ S + ++ N+LKE L + + + + L++ L
Sbjct: 926 GQPSN-----KEDVDDLVSQLR-QTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEESLNK 978
Query: 462 HKKITI---------LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
K++T L ++ Q +L + E+EKEK L+ +A+
Sbjct: 979 EKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKK 1038
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
TL NEV+ + + ++ KI E + + + + +
Sbjct: 1039 ----TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
Query: 573 SLSEKDNKLTELVSTINGLKE-----ENNSLKSLNDVITREK--ETQASELERSCQVI-K 624
+L +++++ S L+E E+ L+ RE+ + + S+ C+ + K
Sbjct: 1095 ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEK 1154
Query: 625 QNGFELDKMK--ADILMXXXXXXXXXXXXXXXXDEAKS---LLEQNLALKEQCEEKTRDC 679
QN D+++ +D ++ +E KS +LE ++ + E
Sbjct: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQ-EDDKLFIEKETKLN--ELTNKYEALKRDYD 736
++ + + E+ R + L+ + E +K+ + +T EL K E + +
Sbjct: 1215 EVAQVESLRYRQRVELLERELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETM----N 1270
Query: 737 AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
++ + RE +L ++ ++ +LE DI Q A
Sbjct: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
+ N+ L K D + ++S+ EV +R+ +E+ LK +
Sbjct: 1331 DVKRWKARNQHLVSQQK-DPDTEEYRKLLSEKEVHT--KRIQQLTEEIGRLKAEIARSNA 1387
Query: 857 ECETCAEYLQERDEQCARLKKEKLSLEQ----QVSNLKEQIRTQQPVER-----QAKFAD 907
+Q E +++ EK ++++ ++ +++E+++T V++ + ++ +
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EK 966
+ D+ D V++ + L +T+ + K + L++ V +QK + EK
Sbjct: 1448 LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEK 1507
Query: 967 YTKK----------DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
T+ E R++L+D + E+L+Q+ E +E+ K +
Sbjct: 1508 ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHL 1567
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+K+ ++ E ++L + AL++Q + L
Sbjct: 1568 AGVKD-QLTKE-NEELKQRNGALDQQKDEL 1595
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 85.4 bits (202), Expect = 1e-15
Identities = 208/1054 (19%), Positives = 424/1054 (40%), Gaps = 76/1054 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS-RTDYEIEKE 488
E ++K++ + + L +L+ + +D +I+Q+ +S R E++++
Sbjct: 490 EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
RL + + E +++S EL +L KS+ + +
Sbjct: 550 NQRLLVALRE---LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ----MQ 602
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST-INGLKEENNSLKSLNDVITR 607
L+ + + D +I +++ + L L ST + S + VI
Sbjct: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
Query: 608 EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
+ +A + Q I +N ++ +K + + + K + + A
Sbjct: 663 TEAIEAKAALKQLQEIFEN-YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFA 721
Query: 668 ------LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
L++ E R+ + L + T + Q ++I + + ++ ++ E +
Sbjct: 722 SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 722 NELTNKYEALKRDYDAAVKDLES---SREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
L + E LK + ES + N L T ++G + E++ + ++ +
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
N D+ +L D+ KR + ++ ++ KE L
Sbjct: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDV----QLLDT-KRQLDTETNLHLN-TKELLK 895
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR-TQQ 897
+ Q+E+ LK+ ++ +Q + R K + S ++ V +L Q+R T++
Sbjct: 896 NAQKEIATLKQHLSNME---------VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
V + + + E + + + + + ++ + +V + R K IE + + + +
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR--KNIEVRLKESAEFQTQL 1004
Query: 958 TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC---AEYLKQREE 1014
K K ME +K + + KR+ +E + +L ELK+ + E + A E+
Sbjct: 1005 EK--KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
Query: 1015 QCKR--LKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q +R ++AKIA+E +K + + +E+L
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Score = 73.7 bits (173), Expect = 3e-12
Identities = 200/1069 (18%), Positives = 420/1069 (39%), Gaps = 79/1069 (7%)
Query: 54 TISCKMCQSLKESSNEINLKLE-KLSGELFDIKEQKSALEGKYQNLILETQTRDL--LMS 110
T+S + ES+ I K K E+F+ +++ A K QN LE + L S
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRS 709
Query: 111 QIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
Q + + K + L D+++ ++I L E N L+ + + +N D
Sbjct: 710 QNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK---QEQIINTMTQD 766
Query: 171 LKKNNECLTQKCIDLEKLVNESEN-KIGPKNICAQCK--LKENLIQSLHIGYDNTLSKLN 227
L+ NE L + E L E E K+ + Q + L E Q+L + T+ +
Sbjct: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL 826
Query: 228 RSISDSNTSTRYN-KICTLQSELDAGREDCKELCEDFTSIKNHLELH--EPNMTMDLDEK 284
S++ T R + +I L+ E+ ++ + E ++ +L++ + +D +
Sbjct: 827 ER-SETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 285 LGENN-EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
L N E A K ++ +K++L+++ Q+ + S+++ K+ + ++ T
Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 344 SL--DVFEILMDNIIN--KYQI---DLDEILEKYTKVQGDLNECTS-ELKSVNEKLASLN 395
D+ E L + N +YQ L+E L K +V ++ + LK E L
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE 1005
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+L+E E L+ K R E S + +KK + +E L+ + + +
Sbjct: 1006 KKLMEVEKEKQELQDDKRRAIE-SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXF 515
+D KI + +YE + + E L+ AK
Sbjct: 1065 RRDCQEQAKIAVEAQ---NKYERELMLHAADVEALQ----AAKEQVSKMASVRQHLEETT 1117
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI----KILSEEIDAL--KIAIAKNEE 569
E E K+ EE ++ K +V + + ++L ++I+ L K+ + E
Sbjct: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEG 1177
Query: 570 KM----LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK---ETQASELERSCQV 622
+SLSE+ +++ + ++ E ++ +V E + LER Q
Sbjct: 1178 VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+ Q+ ++ K + + ++E N L+E+ E +D ++
Sbjct: 1238 L-QDSLNAEREKVQV---TAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ ++ E+ + ++ E + ++ L E +++A + + KD
Sbjct: 1294 QAKVRK----LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDP 1349
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
++ E +L ++K++ RI +L +I +
Sbjct: 1350 DT--EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407
Query: 803 DENRDLGEN--PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD----- 855
E + ++ K+ D ++ ++ ++V ++ R + +EL +++ E
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTI---TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
Query: 856 --DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD 913
E + +QE E + + + SLE QV NL++ + ++ R + + V
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ--EQTVQLQ 1522
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
+ + L + DR + + ++ + ++ + E+ R K+ + + ++ TK+++E
Sbjct: 1523 SELSRLRQDLQDRTTQEEQLRQ--QITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEE 1580
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQ--REEQCKRLKEAKIALEIVDK 1031
+ + L+ K +EL R L + E L++ RE Q + L++ E +K
Sbjct: 1581 LKQRNGALDQQK---DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNK 1637
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKL 1080
+ Q ++QI +L TP S +T N + T V+ K+
Sbjct: 1638 VPEQ----QRQI-TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKV 1681
Score = 71.7 bits (168), Expect = 1e-11
Identities = 208/1075 (19%), Positives = 433/1075 (40%), Gaps = 92/1075 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
K A L+ + + A + +I K + +++ + ++ L E L E +++K
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGM-KLTELYNAYVETQDQLLLEKL--ENKRINKY 422
Query: 448 KIDIPRDLDQDLPAHKKITILFD-ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXX 506
+I ++++ P K+ ++ A LS + KE RL+ T KA
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 507 XXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV--DENNANLNLIKILSEEIDALKIAI 564
+++ +++ L EL + + V DE ++ ++ S E+ + +
Sbjct: 483 ERDNRRMEIQ-VKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS--SSEVISQHLVS 539
Query: 565 AKNEEKMLSLSEK-DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
+N E++ +++ L EL T +EE + S + + E+ +ELE Q+
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETRE--REEQETTSSKITELQLKLESALTELE---QLR 594
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLALKEQCEEKTRDCSRL 682
K ++ + + + A SL + +LA + T
Sbjct: 595 KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK-RPSTSQTVST 653
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ E T I+ + + KQ+QE + + +++ + ++ N E L++ V DL
Sbjct: 654 PAPVPVIESTEAIEAKAAL---KQLQEIFENYKKEKAENEKIQN--EQLEK-LQEQVTDL 707
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
S +++TQ D R L+ ++ + T
Sbjct: 708 RSQN---TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE-LDDECETC 861
+ R G N KL + R+ ++ + E+ +L E LS Q+E ++R + L +T
Sbjct: 765 QDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822
Query: 862 AEYLQERD-EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
L+ + E RL + LE ++S+LK+++ + VE++ NL
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENE--VEQRHTLT----------RNLD 870
Query: 921 SVVVD-RMSYDAEVE---KNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
++D + D E K L+K + E+ KQ L N ++Q A + + K
Sbjct: 871 VQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSN--MEVQVASQSSQRTGKGQP 928
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQ 1035
+ +++++D ++L + +++ +L E +T ++Q + L+E+ + V + +
Sbjct: 929 SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITI 1090
+ + + + T + M V +Q+ + + Q+L ++ L ++
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSV 1043
Score = 68.1 bits (159), Expect = 2e-10
Identities = 169/908 (18%), Positives = 363/908 (39%), Gaps = 65/908 (7%)
Query: 24 RNQ-LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
RNQ L K + II T + ++ + + ++ ++LK+ + L +LS +
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANE-KLAVAEVRAENLKKEKEMLKLSEVRLSQQRE 803
Query: 83 DIKEQKSALEGKYQNL-----ILE---TQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
+ ++ NL ILE T+T+ L SQI+ LE E K+++N +
Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRH 863
Query: 135 TKSKKIN----ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVN 190
T ++ ++ + + + DT +NL + N KE+ LK++ L+ + + +
Sbjct: 864 TLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH---LSNMEVQVASQSS 920
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
+ K P N L L Q+ D K S SN + +L+ L+
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVND---LKERLKTSTSNVEQYQAMVTSLEESLN 977
Query: 251 AGREDCKELCEDF-TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
++ +E+ ++ +K E + + L E E E + + + +++ L+ L
Sbjct: 978 KEKQVTEEVRKNIEVRLKESAEF-QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 310 SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ L ++ + ++ + R +L A + +I ++ NKY+ +L
Sbjct: 1037 KKTL-SSVQNEVQEALQRASTALSNEQQAR--RDCQEQAKIAVE-AQNKYERELMLHAAD 1092
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI--HEISSAV-TIDI 426
+Q E S++ SV + L + + C ++ER+ E+S V +
Sbjct: 1093 VEALQA-AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 427 VKKENELK----EILTKECLKLSKLKIDIPRD--LDQDLPAHKKITILFDALITQYELSR 480
++K+N L E L+ + + K + P + L ++ + ++I + + + E++
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 481 TDYEI-EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL--HEELTKLYK 537
T +E+ + E LR + V E+ K++ HEEL K +
Sbjct: 1212 TRFEVAQVESLRYR----QRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE 1267
Query: 538 SK--VDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING---- 590
+ V E N L K L +++ ++ + K E +L L E + +L+E +
Sbjct: 1268 TMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL 1327
Query: 591 LKEENNSLKSLND-VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
L+E+ K+ N +++++K+ E + + + + ++ +I
Sbjct: 1328 LEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+ +SL E ++ + E +D I+I+ KT ++ R + Q +E
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
++ K+ E + + ++ +V++++ +E +NQ T+ +E ++ L+
Sbjct: 1448 ----LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKT 1503
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + L + + R V + S+
Sbjct: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSK 1563
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
++ L +E ++LK+R LD Q++DE R+ K E ++S L
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALD----------QQKDELDVRITALKSQYEGRISRL 1613
Query: 890 KEQIRTQQ 897
+ ++R Q
Sbjct: 1614 ERELREHQ 1621
Score = 61.3 bits (142), Expect = 2e-08
Identities = 192/1050 (18%), Positives = 415/1050 (39%), Gaps = 104/1050 (9%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
E+ LKLE EL +++ + ++Q ++++ R M +I + + +
Sbjct: 578 ELQLKLESALTELEQLRKSR-----QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
Query: 129 LTD-SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L D SL + K+ + Q + ++E+ TE+ + L++ E ++ + EK
Sbjct: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIES-TEAIEAKAALKQLQEIFENYKKEKAENEK 691
Query: 188 LVNESENKIGPK---------NICAQCKL---KENLIQSLHIGYDNTLSKLNRSISDSNT 235
+ NE K+ + I Q + ++Q GY ++ L+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 236 STRYNK--ICTLQSELDAGRED---CKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN-- 288
+T+ + I T+ +L E + E+ K L+L E ++ + L E
Sbjct: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
Query: 289 -NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLD 346
N T + ++R+ + ++Q ++++ +K + I K L ++ T +LD
Sbjct: 812 QNLLLTNLQTIQGILERS-ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
Query: 347 VFEILMDNIINKYQIDLDEILEKYTK-----VQGDLNECTSELKSVNEKLASLNSQLIEK 401
V L+D K Q+D + L TK Q ++ L ++ ++AS +SQ K
Sbjct: 871 VQ--LLDT---KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
N KE + ++ S + ++ N+LKE L + + + + L++ L
Sbjct: 926 GQPSN-----KEDVDDLVSQLR-QTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEESLNK 978
Query: 462 HKKITI---------LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
K++T L ++ Q +L + E+EKEK L+ +A+
Sbjct: 979 EKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKK 1038
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
TL NEV+ + + ++ KI E + + + + +
Sbjct: 1039 ----TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
Query: 573 SLSEKDNKLTELVSTINGLKE-----ENNSLKSLNDVITREK--ETQASELERSCQVI-K 624
+L +++++ S L+E E+ L+ RE+ + + S+ C+ + K
Sbjct: 1095 ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEK 1154
Query: 625 QNGFELDKMK--ADILMXXXXXXXXXXXXXXXXDEAKS---LLEQNLALKEQCEEKTRDC 679
QN D+++ +D ++ +E KS +LE ++ + E
Sbjct: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQ-EDDKLFIEKETKLN--ELTNKYEALKRDYD 736
++ + + E+ R + LQ + E +K+ + +T EL K E + +
Sbjct: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETM----N 1270
Query: 737 AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
++ + RE +L ++ ++ +LE DI Q A
Sbjct: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
+ N+ L K D + ++S+ EV +R+ +E+ LK +
Sbjct: 1331 DVKRWKARNQHLVSQQK-DPDTEEYRKLLSEKEVHT--KRIQQLTEEIGRLKAEIARSNA 1387
Query: 857 ECETCAEYLQERDEQCARLKKEKLSLEQ----QVSNLKEQIRTQQPVER-----QAKFAD 907
+Q E +++ EK ++++ ++ +++E+++T V++ + ++ +
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EK 966
+ D+ D V++ + L +T+ + K + L++ V +QK + EK
Sbjct: 1448 LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEK 1507
Query: 967 YTKK----------DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
T+ E R++L+D + E+L+Q+ E +E+ K +
Sbjct: 1508 ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHL 1567
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+K+ ++ E ++L + AL++Q + L
Sbjct: 1568 AGVKD-QLTKE-NEELKQRNGALDQQKDEL 1595
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 85.4 bits (202), Expect = 1e-15
Identities = 208/1054 (19%), Positives = 424/1054 (40%), Gaps = 76/1054 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS-RTDYEIEKE 488
E ++K++ + + L +L+ + +D +I+Q+ +S R E++++
Sbjct: 490 EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
RL + + E +++S EL +L KS+ + +
Sbjct: 550 NQRLLVALRE---LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ----MQ 602
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST-INGLKEENNSLKSLNDVITR 607
L+ + + D +I +++ + L L ST + S + VI
Sbjct: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
Query: 608 EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
+ +A + Q I +N ++ +K + + + K + + A
Sbjct: 663 TEAIEAKAALKQLQEIFEN-YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFA 721
Query: 668 ------LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
L++ E R+ + L + T + Q ++I + + ++ ++ E +
Sbjct: 722 SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 722 NELTNKYEALKRDYDAAVKDLES---SREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
L + E LK + ES + N L T ++G + E++ + ++ +
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
N D+ +L D+ KR + ++ ++ KE L
Sbjct: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDV----QLLDT-KRQLDTETNLHLN-TKELLK 895
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR-TQQ 897
+ Q+E+ LK+ ++ +Q + R K + S ++ V +L Q+R T++
Sbjct: 896 NAQKEIATLKQHLSNME---------VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
V + + + E + + + + + ++ + +V + R K IE + + + +
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR--KNIEVRLKESAEFQTQL 1004
Query: 958 TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC---AEYLKQREE 1014
K K ME +K + + KR+ +E + +L ELK+ + E + A E+
Sbjct: 1005 EK--KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
Query: 1015 QCKR--LKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q +R ++AKIA+E +K + + +E+L
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Score = 73.7 bits (173), Expect = 3e-12
Identities = 200/1069 (18%), Positives = 420/1069 (39%), Gaps = 79/1069 (7%)
Query: 54 TISCKMCQSLKESSNEINLKLE-KLSGELFDIKEQKSALEGKYQNLILETQTRDL--LMS 110
T+S + ES+ I K K E+F+ +++ A K QN LE + L S
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRS 709
Query: 111 QIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
Q + + K + L D+++ ++I L E N L+ + + +N D
Sbjct: 710 QNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK---QEQIINTMTQD 766
Query: 171 LKKNNECLTQKCIDLEKLVNESEN-KIGPKNICAQCK--LKENLIQSLHIGYDNTLSKLN 227
L+ NE L + E L E E K+ + Q + L E Q+L + T+ +
Sbjct: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL 826
Query: 228 RSISDSNTSTRYN-KICTLQSELDAGREDCKELCEDFTSIKNHLELH--EPNMTMDLDEK 284
S++ T R + +I L+ E+ ++ + E ++ +L++ + +D +
Sbjct: 827 ER-SETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 285 LGENN-EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
L N E A K ++ +K++L+++ Q+ + S+++ K+ + ++ T
Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 344 SL--DVFEILMDNIIN--KYQI---DLDEILEKYTKVQGDLNECTS-ELKSVNEKLASLN 395
D+ E L + N +YQ L+E L K +V ++ + LK E L
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE 1005
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+L+E E L+ K R E S + +KK + +E L+ + + +
Sbjct: 1006 KKLMEVEKEKQELQDDKRRAIE-SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXF 515
+D KI + +YE + + E L+ AK
Sbjct: 1065 RRDCQEQAKIAVEAQ---NKYERELMLHAADVEALQ----AAKEQVSKMASVRQHLEETT 1117
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI----KILSEEIDAL--KIAIAKNEE 569
E E K+ EE ++ K +V + + ++L ++I+ L K+ + E
Sbjct: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEG 1177
Query: 570 KM----LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK---ETQASELERSCQV 622
+SLSE+ +++ + ++ E ++ +V E + LER Q
Sbjct: 1178 VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+ Q+ ++ K + + ++E N L+E+ E +D ++
Sbjct: 1238 L-QDSLNAEREKVQV---TAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ ++ E+ + ++ E + ++ L E +++A + + KD
Sbjct: 1294 QAKVRK----LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDP 1349
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
++ E +L ++K++ RI +L +I +
Sbjct: 1350 DT--EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407
Query: 803 DENRDLGEN--PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD----- 855
E + ++ K+ D ++ ++ ++V ++ R + +EL +++ E
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTI---TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
Query: 856 --DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD 913
E + +QE E + + + SLE QV NL++ + ++ R + + V
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ--EQTVQLQ 1522
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
+ + L + DR + + ++ + ++ + E+ R K+ + + ++ TK+++E
Sbjct: 1523 SELSRLRQDLQDRTTQEEQLRQ--QITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEE 1580
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQ--REEQCKRLKEAKIALEIVDK 1031
+ + L+ K +EL R L + E L++ RE Q + L++ E +K
Sbjct: 1581 LKQRNGALDQQK---DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNK 1637
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKL 1080
+ Q ++QI +L TP S +T N + T V+ K+
Sbjct: 1638 VPEQ----QRQI-TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKV 1681
Score = 71.7 bits (168), Expect = 1e-11
Identities = 208/1075 (19%), Positives = 433/1075 (40%), Gaps = 92/1075 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
K A L+ + + A + +I K + +++ + ++ L E L E +++K
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGM-KLTELYNAYVETQDQLLLEKL--ENKRINKY 422
Query: 448 KIDIPRDLDQDLPAHKKITILFD-ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXX 506
+I ++++ P K+ ++ A LS + KE RL+ T KA
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 507 XXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV--DENNANLNLIKILSEEIDALKIAI 564
+++ +++ L EL + + V DE ++ ++ S E+ + +
Sbjct: 483 ERDNRRMEIQ-VKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS--SSEVISQHLVS 539
Query: 565 AKNEEKMLSLSEK-DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
+N E++ +++ L EL T +EE + S + + E+ +ELE Q+
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETRE--REEQETTSSKITELQLKLESALTELE---QLR 594
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLALKEQCEEKTRDCSRL 682
K ++ + + + A SL + +LA + T
Sbjct: 595 KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK-RPSTSQTVST 653
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ E T I+ + + KQ+QE + + +++ + ++ N E L++ V DL
Sbjct: 654 PAPVPVIESTEAIEAKAAL---KQLQEIFENYKKEKAENEKIQN--EQLEK-LQEQVTDL 707
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
S +++TQ D R L+ ++ + T
Sbjct: 708 RSQN---TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE-LDDECETC 861
+ R G N KL + R+ ++ + E+ +L E LS Q+E ++R + L +T
Sbjct: 765 QDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822
Query: 862 AEYLQERD-EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
L+ + E RL + LE ++S+LK+++ + VE++ NL
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENE--VEQRHTLT----------RNLD 870
Query: 921 SVVVD-RMSYDAEVE---KNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
++D + D E K L+K + E+ KQ L N ++Q A + + K
Sbjct: 871 VQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSN--MEVQVASQSSQRTGKGQP 928
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQ 1035
+ +++++D ++L + +++ +L E +T ++Q + L+E+ + V + +
Sbjct: 929 SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITI 1090
+ + + + T + M V +Q+ + + Q+L ++ L ++
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSV 1043
Score = 68.1 bits (159), Expect = 2e-10
Identities = 169/908 (18%), Positives = 363/908 (39%), Gaps = 65/908 (7%)
Query: 24 RNQ-LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
RNQ L K + II T + ++ + + ++ ++LK+ + L +LS +
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANE-KLAVAEVRAENLKKEKEMLKLSEVRLSQQRE 803
Query: 83 DIKEQKSALEGKYQNL-----ILE---TQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
+ ++ NL ILE T+T+ L SQI+ LE E K+++N +
Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRH 863
Query: 135 TKSKKIN----ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVN 190
T ++ ++ + + + DT +NL + N KE+ LK++ L+ + + +
Sbjct: 864 TLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH---LSNMEVQVASQSS 920
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
+ K P N L L Q+ D K S SN + +L+ L+
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVND---LKERLKTSTSNVEQYQAMVTSLEESLN 977
Query: 251 AGREDCKELCEDF-TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
++ +E+ ++ +K E + + L E E E + + + +++ L+ L
Sbjct: 978 KEKQVTEEVRKNIEVRLKESAEF-QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 310 SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ L ++ + ++ + R +L A + +I ++ NKY+ +L
Sbjct: 1037 KKTL-SSVQNEVQEALQRASTALSNEQQAR--RDCQEQAKIAVE-AQNKYERELMLHAAD 1092
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI--HEISSAV-TIDI 426
+Q E S++ SV + L + + C ++ER+ E+S V +
Sbjct: 1093 VEALQA-AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 427 VKKENELK----EILTKECLKLSKLKIDIPRD--LDQDLPAHKKITILFDALITQYELSR 480
++K+N L E L+ + + K + P + L ++ + ++I + + + E++
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 481 TDYEI-EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL--HEELTKLYK 537
T +E+ + E LR + V E+ K++ HEEL K +
Sbjct: 1212 TRFEVAQVESLRYR----QRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE 1267
Query: 538 SK--VDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING---- 590
+ V E N L K L +++ ++ + K E +L L E + +L+E +
Sbjct: 1268 TMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL 1327
Query: 591 LKEENNSLKSLND-VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
L+E+ K+ N +++++K+ E + + + + ++ +I
Sbjct: 1328 LEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+ +SL E ++ + E +D I+I+ KT ++ R + Q +E
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
++ K+ E + + ++ +V++++ +E +NQ T+ +E ++ L+
Sbjct: 1448 ----LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKT 1503
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + L + + R V + S+
Sbjct: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSK 1563
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
++ L +E ++LK+R LD Q++DE R+ K E ++S L
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALD----------QQKDELDVRITALKSQYEGRISRL 1613
Query: 890 KEQIRTQQ 897
+ ++R Q
Sbjct: 1614 ERELREHQ 1621
Score = 61.3 bits (142), Expect = 2e-08
Identities = 192/1050 (18%), Positives = 415/1050 (39%), Gaps = 104/1050 (9%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
E+ LKLE EL +++ + ++Q ++++ R M +I + + +
Sbjct: 578 ELQLKLESALTELEQLRKSR-----QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
Query: 129 LTD-SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L D SL + K+ + Q + ++E+ TE+ + L++ E ++ + EK
Sbjct: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIES-TEAIEAKAALKQLQEIFENYKKEKAENEK 691
Query: 188 LVNESENKIGPK---------NICAQCKL---KENLIQSLHIGYDNTLSKLNRSISDSNT 235
+ NE K+ + I Q + ++Q GY ++ L+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 236 STRYNK--ICTLQSELDAGRED---CKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN-- 288
+T+ + I T+ +L E + E+ K L+L E ++ + L E
Sbjct: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
Query: 289 -NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLD 346
N T + ++R+ + ++Q ++++ +K + I K L ++ T +LD
Sbjct: 812 QNLLLTNLQTIQGILERS-ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
Query: 347 VFEILMDNIINKYQIDLDEILEKYTK-----VQGDLNECTSELKSVNEKLASLNSQLIEK 401
V L+D K Q+D + L TK Q ++ L ++ ++AS +SQ K
Sbjct: 871 VQ--LLDT---KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
N KE + ++ S + ++ N+LKE L + + + + L++ L
Sbjct: 926 GQPSN-----KEDVDDLVSQLR-QTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEESLNK 978
Query: 462 HKKITI---------LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
K++T L ++ Q +L + E+EKEK L+ +A+
Sbjct: 979 EKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKK 1038
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
TL NEV+ + + ++ KI E + + + + +
Sbjct: 1039 ----TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
Query: 573 SLSEKDNKLTELVSTINGLKE-----ENNSLKSLNDVITREK--ETQASELERSCQVI-K 624
+L +++++ S L+E E+ L+ RE+ + + S+ C+ + K
Sbjct: 1095 ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEK 1154
Query: 625 QNGFELDKMK--ADILMXXXXXXXXXXXXXXXXDEAKS---LLEQNLALKEQCEEKTRDC 679
QN D+++ +D ++ +E KS +LE ++ + E
Sbjct: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQ-EDDKLFIEKETKLN--ELTNKYEALKRDYD 736
++ + + E+ R + LQ + E +K+ + +T EL K E + +
Sbjct: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETM----N 1270
Query: 737 AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
++ + RE +L ++ ++ +LE DI Q A
Sbjct: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
+ N+ L K D + ++S+ EV +R+ +E+ LK +
Sbjct: 1331 DVKRWKARNQHLVSQQK-DPDTEEYRKLLSEKEVHT--KRIQQLTEEIGRLKAEIARSNA 1387
Query: 857 ECETCAEYLQERDEQCARLKKEKLSLEQ----QVSNLKEQIRTQQPVER-----QAKFAD 907
+Q E +++ EK ++++ ++ +++E+++T V++ + ++ +
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EK 966
+ D+ D V++ + L +T+ + K + L++ V +QK + EK
Sbjct: 1448 LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEK 1507
Query: 967 YTKK----------DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
T+ E R++L+D + E+L+Q+ E +E+ K +
Sbjct: 1508 ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHL 1567
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+K+ ++ E ++L + AL++Q + L
Sbjct: 1568 AGVKD-QLTKE-NEELKQRNGALDQQKDEL 1595
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein.
Length = 2363
Score = 84.2 bits (199), Expect = 2e-15
Identities = 208/1054 (19%), Positives = 423/1054 (40%), Gaps = 76/1054 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELS-RTDYEIEKE 488
E ++K++ + + L +L+ + +D +I+Q+ +S R E++++
Sbjct: 490 EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
RL + + E +++S EL +L KS+ + +
Sbjct: 550 NQRLLVALRE---LGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ----MQ 602
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST-INGLKEENNSLKSLNDVITR 607
L+ + + D +I +++ + L L ST + S + VI
Sbjct: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
Query: 608 EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
+ +A + Q I +N ++ +K + + + K + + A
Sbjct: 663 TEAIEAKAALKQLQEIFEN-YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFA 721
Query: 668 ------LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
L++ E R+ + L + T + Q ++I + + ++ ++ E +
Sbjct: 722 SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEIRA 781
Query: 722 NELTNKYEALKRDYDAAVKDLES---SREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
L + E LK + ES + N L T ++G + E++ + ++ +
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
N D+ +L D+ KR + ++ ++ KE L
Sbjct: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDV----QLLDT-KRQLDTETNLHLN-TKELLK 895
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR-TQQ 897
+ Q+E+ LK ++ +Q + R K + S ++ V +L Q+R T++
Sbjct: 896 NAQKEIATLKRHLSNME---------VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
V + + + E + + + + + ++ + +V + R K IE + + + +
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR--KNIEVRLKESAEFQTQL 1004
Query: 958 TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC---AEYLKQREE 1014
K K ME +K + + KR+ +E + +L ELK+ + E + A E+
Sbjct: 1005 EK--KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
Query: 1015 QCKR--LKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q +R ++AKIA+E +K + + +E+L
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Score = 75.8 bits (178), Expect = 8e-13
Identities = 202/1069 (18%), Positives = 420/1069 (39%), Gaps = 79/1069 (7%)
Query: 54 TISCKMCQSLKESSNEINLKLE-KLSGELFDIKEQKSALEGKYQNLILETQTRDL--LMS 110
T+S + ES+ I K K E+F+ +++ A K QN LE + L S
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRS 709
Query: 111 QIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
Q + + K + L D+++ ++I L E N L+ + + +N D
Sbjct: 710 QNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK---QEQIINTMTQD 766
Query: 171 LKKNNECLTQKCIDLEKLVNESEN-KIGPKNICAQCK--LKENLIQSLHIGYDNTLSKLN 227
L+ NE L I E L E E K+ + Q + L E Q+L + T+ +
Sbjct: 767 LRGANEKLAVAEIRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL 826
Query: 228 RSISDSNTSTRYN-KICTLQSELDAGREDCKELCEDFTSIKNHLELH--EPNMTMDLDEK 284
S++ T R + +I L+ E+ ++ + E ++ +L++ + +D +
Sbjct: 827 ER-SETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 285 LGENN-EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
L N E A K ++ +KR+L+++ Q+ + S+++ K+ + ++ T
Sbjct: 886 LHLNTKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 344 SL--DVFEILMDNIIN--KYQI---DLDEILEKYTKVQGDLNECTS-ELKSVNEKLASLN 395
D+ E L + N +YQ L+E L K +V ++ + LK E L
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE 1005
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+L+E E L+ K R E S + +KK + +E L+ + + +
Sbjct: 1006 KKLMEVEKEKQELQDDKRRAIE-SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXF 515
+D KI + +YE + + E L+ AK
Sbjct: 1065 RRDCQEQAKIAVEAQ---NKYERELMLHAADVEALQ----AAKEQVSKMASVRQHLEETT 1117
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI----KILSEEIDAL--KIAIAKNEE 569
E E K+ EE ++ K +V + + ++L ++I+ L K+ + E
Sbjct: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEG 1177
Query: 570 KM----LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK---ETQASELERSCQV 622
+SLSE+ +++ + ++ E ++ +V E + LER Q
Sbjct: 1178 VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+ Q+ ++ K + + ++E N L+E+ E +D ++
Sbjct: 1238 L-QDSLNAEREKVQV---TAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ ++ E+ + ++ E + ++ L E +++A + + KD
Sbjct: 1294 QAKVRK----LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDP 1349
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
++ E +L ++K++ RI +L +I +
Sbjct: 1350 DT--EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVR 1407
Query: 803 DENRDLGEN--PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD----- 855
E + ++ K+ D ++ ++ ++V ++ R + +EL +++ E
Sbjct: 1408 TEKETIQKDLDAKIIDIQEKVKTI---TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
Query: 856 --DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD 913
E + +QE E + + + SLE QV NL++ + ++ R + + V
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ--EQTVQLQ 1522
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
+ + L + DR + + ++ + ++ + E+ R K+ + + ++ TK+++E
Sbjct: 1523 SELSRLRQDLQDRTTQEEQLRQ--QITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEE 1580
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQ--REEQCKRLKEAKIALEIVDK 1031
+ + L+ K +EL R L + E L++ RE Q + L++ E +K
Sbjct: 1581 LKQRNGALDQQK---DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNK 1637
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKL 1080
+ Q ++QI +L TP S +T N + T V+ K+
Sbjct: 1638 VPEQ----QRQI-TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKV 1681
Score = 70.5 bits (165), Expect = 3e-11
Identities = 212/1091 (19%), Positives = 424/1091 (38%), Gaps = 103/1091 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKE--RIHEISSAV--TID---IVKKENELKEILTKE 440
K A L+ + + A + +I K ++ E+ +A T D + K EN+ E
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE 425
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ--YELSRTDYEIEKEKLR---LETG 495
+K + K I + ++ +K + Q E+ R + +K + LE
Sbjct: 426 IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK----VDENNANLNLIK 551
+ + LEEA EE++ S + ++ + I+
Sbjct: 486 NRRMEIQVKDLSQQIRVLLME-LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIE 544
Query: 552 ILSEEIDALKIAI-------AKNEEKMLS--LSEKDNKLTELVSTINGLKEENNSLKSLN 602
L ++ L +A+ + E++ S ++E KL ++ + L++ L
Sbjct: 545 ELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLV 604
Query: 603 DVITREKETQASELERSCQV-IKQNGFELDKMK-ADILMXXXXXXXXXXXXXXXXDEAKS 660
D I R+++ L ++ V I + LD + A E+
Sbjct: 605 DSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTE 664
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+E ALK+ E E K + +IQN + +LQ+Q+ + + T+
Sbjct: 665 AIEAKAALKQLQE-------IFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
L+ + +YE L+ + + +++ S E +LT E I + D+R
Sbjct: 718 LDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDL-----GENPKLDDSPKRSISVISDSEVSQLKE 835
+ L G+N L + ++I I + ++ K+
Sbjct: 778 EIRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTN--LQTIQGILERSETETKQ 835
Query: 836 RLLSCQQELD-DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS-NLKEQI 893
RL S ++L+ ++ K+L++E E + D Q K++ L E + N KE +
Sbjct: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ-LDTETNLHLNTKELL 894
Query: 894 RTQQ----PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
+ Q ++R +V V + ++ D V +L +T E++
Sbjct: 895 KNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV---SQLRQTEEQVNDL 951
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
K+ LK + + +++ T ++ +++ E+ + +E R KE E + L
Sbjct: 952 KERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIE---VRLKESAEFQTQLEKKL 1008
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ 1069
+ E++ + L++ K ++ + Q L+K + S+ N V + +T A+ QQ
Sbjct: 1009 MEVEKEKQELQDDK--RRAIESMEQQLSELKKTLSSVQN-EVQEALQRAST--ALSNEQQ 1063
Query: 1070 ITDVMKENQKL 1080
+E K+
Sbjct: 1064 ARRDCQEQAKI 1074
Score = 68.1 bits (159), Expect = 2e-10
Identities = 169/908 (18%), Positives = 363/908 (39%), Gaps = 65/908 (7%)
Query: 24 RNQ-LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
RNQ L K + II T + ++ + + ++ ++LK+ + L +LS +
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANE-KLAVAEIRAENLKKEKEMLKLSEVRLSQQRE 803
Query: 83 DIKEQKSALEGKYQNL-----ILE---TQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
+ ++ NL ILE T+T+ L SQI+ LE E K+++N +
Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRH 863
Query: 135 TKSKKIN----ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVN 190
T ++ ++ + + + DT +NL + N KE+ LK++ L+ + + +
Sbjct: 864 TLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKRH---LSNMEVQVASQSS 920
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
+ K P N L L Q+ D K S SN + +L+ L+
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVND---LKERLKTSTSNVEQYQAMVTSLEESLN 977
Query: 251 AGREDCKELCEDF-TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
++ +E+ ++ +K E + + L E E E + + + +++ L+ L
Sbjct: 978 KEKQVTEEVRKNIEVRLKESAEF-QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 310 SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ L ++ + ++ + R +L A + +I ++ NKY+ +L
Sbjct: 1037 KKTL-SSVQNEVQEALQRASTALSNEQQAR--RDCQEQAKIAVE-AQNKYERELMLHAAD 1092
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI--HEISSAV-TIDI 426
+Q E S++ SV + L + + C ++ER+ E+S V +
Sbjct: 1093 VEALQA-AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 427 VKKENELK----EILTKECLKLSKLKIDIPRD--LDQDLPAHKKITILFDALITQYELSR 480
++K+N L E L+ + + K + P + L ++ + ++I + + + E++
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 481 TDYEI-EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL--HEELTKLYK 537
T +E+ + E LR + V E+ K++ HEEL K +
Sbjct: 1212 TRFEVAQVESLRYR----QRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE 1267
Query: 538 SK--VDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING---- 590
+ V E N L K L +++ ++ + K E +L L E + +L+E +
Sbjct: 1268 TMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL 1327
Query: 591 LKEENNSLKSLND-VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
L+E+ K+ N +++++K+ E + + + + ++ +I
Sbjct: 1328 LEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+ +SL E ++ + E +D I+I+ KT ++ R + Q +E
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
++ K+ E + + ++ +V++++ +E +NQ T+ +E ++ L+
Sbjct: 1448 ----LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKT 1503
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + L + + R V + S+
Sbjct: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSK 1563
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
++ L +E ++LK+R LD Q++DE R+ K E ++S L
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALD----------QQKDELDVRITALKSQYEGRISRL 1613
Query: 890 KEQIRTQQ 897
+ ++R Q
Sbjct: 1614 ERELREHQ 1621
Score = 60.5 bits (140), Expect = 3e-08
Identities = 193/1050 (18%), Positives = 416/1050 (39%), Gaps = 104/1050 (9%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
E+ LKLE EL +++ + ++Q ++++ R M +I + + +
Sbjct: 578 ELQLKLESALTELEQLRKSR-----QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
Query: 129 LTD-SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L D SL + K+ + Q + ++E+ TE+ + L++ E ++ + EK
Sbjct: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIES-TEAIEAKAALKQLQEIFENYKKEKAENEK 691
Query: 188 LVNESENKIGPK---------NICAQCKL---KENLIQSLHIGYDNTLSKLNRSISDSNT 235
+ NE K+ + I Q + ++Q GY ++ L+
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 236 STRYNK--ICTLQSELDAGREDCK--EL-CEDFTSIKNHLELHEPNMTMDLDEKLGEN-- 288
+T+ + I T+ +L E E+ E+ K L+L E ++ + L E
Sbjct: 752 TTQKQEQIINTMTQDLRGANEKLAVAEIRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
Query: 289 -NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLD 346
N T + ++R+ + ++Q ++++ +K + I K L ++ T +LD
Sbjct: 812 QNLLLTNLQTIQGILERS-ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
Query: 347 VFEILMDNIINKYQIDLDEILEKYTK-----VQGDLNECTSELKSVNEKLASLNSQLIEK 401
V L+D K Q+D + L TK Q ++ L ++ ++AS +SQ K
Sbjct: 871 VQ--LLDT---KRQLDTETNLHLNTKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGK 925
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
N KE + ++ S + ++ N+LKE L + + + + L++ L
Sbjct: 926 GQPSN-----KEDVDDLVSQLR-QTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEESLNK 978
Query: 462 HKKITI---------LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
K++T L ++ Q +L + E+EKEK L+ +A+
Sbjct: 979 EKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKK 1038
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
TL NEV+ + + ++ KI E + + + + +
Sbjct: 1039 ----TLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
Query: 573 SLSEKDNKLTELVSTINGLKE-----ENNSLKSLNDVITREK--ETQASELERSCQVI-K 624
+L +++++ S L+E E+ L+ RE+ + + S+ C+ + K
Sbjct: 1095 ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEK 1154
Query: 625 QNGFELDKMK--ADILMXXXXXXXXXXXXXXXXDEAKS---LLEQNLALKEQCEEKTRDC 679
QN D+++ +D ++ +E KS +LE ++ + E
Sbjct: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQ-EDDKLFIEKETKLN--ELTNKYEALKRDYD 736
++ + + E+ R + LQ + E +K+ + +T EL K E + +
Sbjct: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETM----N 1270
Query: 737 AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
++ + RE +L ++ ++ +LE DI Q A
Sbjct: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
+ N+ L K D + ++S+ EV +R+ +E+ LK +
Sbjct: 1331 DVKRWKARNQHLVSQQK-DPDTEEYRKLLSEKEVHT--KRIQQLTEEIGRLKAEIARSNA 1387
Query: 857 ECETCAEYLQERDEQCARLKKEKLSLEQ----QVSNLKEQIRTQQPVER-----QAKFAD 907
+Q E +++ EK ++++ ++ +++E+++T V++ + ++ +
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EK 966
+ D+ D V++ + L +T+ + K + L++ V +QK + EK
Sbjct: 1448 LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEK 1507
Query: 967 YTKK----------DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
T+ E R++L+D + E+L+Q+ E +E+ K +
Sbjct: 1508 ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHL 1567
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+K+ ++ E ++L + AL++Q + L
Sbjct: 1568 AGVKD-QLTKE-NEELKQRNGALDQQKDEL 1595
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated
microtubule-binding protein protein.
Length = 1979
Score = 83.0 bits (196), Expect = 5e-15
Identities = 218/1059 (20%), Positives = 416/1059 (39%), Gaps = 93/1059 (8%)
Query: 80 ELFDIKEQKSALEGKYQ---NLILETQTRDLLMSQ--IKSLEMENLTKDKEIKNLTDSLK 134
EL D +E+ LE Q + ++ET + Q I+ L++E + K+++ L D +K
Sbjct: 257 ELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIK 316
Query: 135 TKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE-KLVNESE 193
+KK++ + + D L E + LN E + + E L +C L+ V +S+
Sbjct: 317 DINKKLSSAENDRDILRR-------EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSD 369
Query: 194 NKIGPKNICAQCKLKENL--IQSLHIGYDNT---LSKLNR--SISDSNTSTRYNKICTLQ 246
+ I AQ E + +Q +N LS LN+ S+++ N + +I L+
Sbjct: 370 TMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM-RIEVLE 428
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMD--LDEKLGENN-EFETKAVKVMSEI- 302
E ++ +EL + N E+ + T D LD +L + E K ++ I
Sbjct: 429 KEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSIS 488
Query: 303 -KRNLNSLSEQLI--NNESKKS----KDHIDRYK---DSLLAVLDAEFGTTSLDVFEILM 352
K L + E+L N E+ K KD + + + DS+++ L + V ++
Sbjct: 489 EKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLED 548
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
D + ++D+ + EK + + LN+ + + +K+ +L QL K N+ IQK
Sbjct: 549 DKMDITKELDVQK--EKLIQSEVALNDLHLTKQKLEDKVENLVDQL-NKSQESNV-SIQK 604
Query: 413 ERIH--EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
E + E ++ + NEL + L ++ S K + ++ + ++ K+ +
Sbjct: 605 ENLELKEHIRQNEEELSRIRNELMQSLNQD--SNSNFKDTLLKEREAEVRNLKQNLSELE 662
Query: 471 ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS-LH 529
L + D ++E EKL L + +T+ E K +
Sbjct: 663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIE 722
Query: 530 EELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK-DNKLTELVSTI 588
EL K ++E N I+ LS + A+ E ++ L++K D ++ EL I
Sbjct: 723 AELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNI 782
Query: 589 NGLKEENNSLKS-LNDVITREKE-TQA-SELERSCQVIKQNGF----ELDKM-----KAD 636
+ ++ K L+ + +K+ TQ ++ E + +K+ ELDK K +
Sbjct: 783 EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE 842
Query: 637 ILMXXXXXXXXXXXXXXXX-----DEAKSLLEQNLALKEQCEEKTRDC------------ 679
IL +E + L E+ + KT D
Sbjct: 843 ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLN 902
Query: 680 ---SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD 736
LE IK H+K E QN+ M+L + +QE K E + ++ + L + D
Sbjct: 903 TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKD 962
Query: 737 AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
+K L+ + + Q+ TQ I SDI ++T
Sbjct: 963 EEIKSLQ---KTIEQIKTQLHEERQDIQTDNSDI-FQETKVQSLNIENGSEKHDLSKAET 1018
Query: 797 XXXTFGDENRDLGENPKLDD---SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKE 853
G + R+L E L++ S + I +S EV +L + + E+ L R
Sbjct: 1019 ERLVKGIKEREL-EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISS 1077
Query: 854 LDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA-DVAVNT 912
+ YLQ++ + A +++ ++ + + ++T+ A + A+
Sbjct: 1078 TSHTQDVV--YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+D S + D E + L + I E + L + ++ + ++
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE 1195
Query: 973 EFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---IV 1029
+ E+ E ++LKQ+ K+++E + ++ + + +L+E L+ +V
Sbjct: 1196 AGGVNSHQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
Query: 1030 DKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ 1068
D +N K L+ L + N T G + Q Q
Sbjct: 1256 DSDNNSK--LQVDYTGLIQSYEQNETKLKNFGQELAQVQ 1292
Score = 71.3 bits (167), Expect = 2e-11
Identities = 123/609 (20%), Positives = 250/609 (41%), Gaps = 59/609 (9%)
Query: 518 LEEAHN----EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
L+ AH E+ H E Y+ +++E L E D KI + ++L
Sbjct: 239 LQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ 298
Query: 574 LS--EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
+ E K+ +L I + ++ +S ++ D++ RE+E E + + + E
Sbjct: 299 IEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECS 358
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
K++ + +E+ L++ + + RL ++
Sbjct: 359 KLQPSAVKQSDTMTEKERILAQSAS-----VEEVFRLQQALSDAENEIMRLS-SLNQDNS 412
Query: 692 TAEIQNRMIMRLQKQIQEDDKLFIEKET---KLNELTNKYEALK----RDY--DAAVKDL 742
AE ++ MR++ +E L EKE L +L N+YE +K RD D+ + DL
Sbjct: 413 LAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDL 472
Query: 743 ESSREAVNQLTTQK-DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ EA Q Q E IAE+E R Q AT
Sbjct: 473 RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
+ D E ++ + + + +V KE+L+ + L+DL ++L+D+ E
Sbjct: 533 KQDLND--EKKRVHQLEDDKMDITKELDVQ--KEKLIQSEVALNDLHLTKQKLEDKVENL 588
Query: 862 AEYLQERDEQCARLKKEKLSL-------EQQVSNLKEQIRTQQPVERQAKFADVAV---- 910
+ L + E ++KE L L E+++S ++ ++ + + F D +
Sbjct: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKERE 648
Query: 911 ----NTDEDWANLHSV--VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM 964
N ++ + L + + ++++D ++E N++L+ E++R++ ++ Q ++
Sbjct: 649 AEVRNLKQNLSELEQLNENLKKVAFDVKME-NEKLVLACEDVRHQLEEC--LAGNNQLSL 705
Query: 965 EKYTKKDKEFEAKRKELEDCKAELEELKQR-YKELDEECETCAEYLKQREEQCKRLK-EA 1022
EK T E + E + +AEL K+R +E ++ +T E R L+ E
Sbjct: 706 EKNT----IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEH 761
Query: 1023 KIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN----Q 1078
+ +++ K + L+K IE + + S++ + +Q+T ++ + +
Sbjct: 762 EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV---LSSSLEEQKQLTQLINKKEIFIE 818
Query: 1079 KLKKMNAKL 1087
KLK+ ++KL
Sbjct: 819 KLKERSSKL 827
Score = 66.9 bits (156), Expect = 4e-10
Identities = 191/1088 (17%), Positives = 437/1088 (40%), Gaps = 92/1088 (8%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R+QL+ + N+ + ++ ++ I ++C + K E N K EK EL +
Sbjct: 690 RHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEAN-KYEKTIEELSN 748
Query: 84 IKE-QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ SAL+ ++++LI Q +D+ ++++K + T KE K++ S + K++ +
Sbjct: 749 ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 808
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L + + + E S L +E+D K ++ L + I L + + E + +G
Sbjct: 809 LINKKEIFIEKLKER---SSKLQEELD---KYSQALRKNEI-LRQTIEEKDRSLGSMKE- 860
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICTLQSELDAGREDCKELC 260
L+E L + L T + DS T ++ +++ T++ L+ + +++
Sbjct: 861 ENNHLQEEL-ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKII 919
Query: 261 EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQL 313
ED K L ++DE ++ + ++ E +++ + + QL
Sbjct: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII-------------NKYQ 360
D+ D ++++ + L+ E G+ D+ + + ++ N+
Sbjct: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN 1039
Query: 361 IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEIS 419
I L + +++ +K ++ + T ++ + ++ +L++++ + +++ +Q++ + + +
Sbjct: 1040 ISLTKQIDQLSK--DEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME 1097
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL------I 473
++ ++ L E K+ + L + +KK++ F++
Sbjct: 1098 REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRE 1157
Query: 474 TQYELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
T LSR + +IE + L + T AV EE E L ++
Sbjct: 1158 TIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQFEELLQERDKLKQQ 1217
Query: 532 LTKL--YKSKVDENNANLNLIKI-LSEEIDALKIAI---AKNEEKML--------SLSEK 577
+ K+ +K +V N+ L EE+ L+ + + N K+ S +
Sbjct: 1218 VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQN 1277
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
+ KL + ++ L + D++ + + + +L + + Q+ L K+++
Sbjct: 1278 ETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
L + KSL E++ ++ E R + + K E +
Sbjct: 1338 L-----SESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1392
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
I +L+++ KL EK+ + +++ + ++ V + E R+AV L +
Sbjct: 1393 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL 1452
Query: 758 LVEGRIAELESD----IRTEQ-TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++E I +L+ + + T + T + + L
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512
Query: 813 KLDDSPKRSISVISD--SEVSQLKERLLSCQQELDD----LKERYKE---LDDECETCAE 863
L + + ++ + V ++E+ + QQE D LK++ E L +E + +
Sbjct: 1513 LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD 1572
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+++ RL+ LE + S +E + + +R+AK +E + S
Sbjct: 1573 KEFRSNQELERLRNH--LLESEDSYTREALAAE---DREAKLRKKVTVLEEKLVS-SSNA 1626
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA-----KR 978
++ S+ A V+ + L + + + ++ + ++ Q+ +++Y + ++
Sbjct: 1627 MENASHQASVQV-ESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQ 1685
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+E AELE+ KQ E + E + +E C L EA AL+ +L+ Q
Sbjct: 1686 EEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE-C--LDEANAALDSASRLTEQLDV 1742
Query: 1039 LEKQIESL 1046
E+QIE L
Sbjct: 1743 KEEQIEEL 1750
Score = 43.6 bits (98), Expect = 0.004
Identities = 47/221 (21%), Positives = 98/221 (44%), Gaps = 13/221 (5%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+EV +L+++ QEL+ L+ E +D A ++R+ A+L+K+ LE+++
Sbjct: 1565 NEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE---AKLRKKVTVLEEKL- 1620
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV--EKNKRLMKTIEE 945
+ + +E + A V V + ++ N+ S D + V E+ K+ ++
Sbjct: 1621 -----VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
Query: 946 LRYKKQDLKNTVTKMQKA-MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
L+ + + M A +EK + E++ + LE L+E +
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASR 1735
Query: 1005 CAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALEKQIE 1044
E L +EEQ + LK + ++ E++D + + ++L E
Sbjct: 1736 LTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776
Score = 36.7 bits (81), Expect = 0.46
Identities = 53/248 (21%), Positives = 112/248 (45%), Gaps = 21/248 (8%)
Query: 806 RDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
++L +N + D + +SV+ ++ +L E ++EL D +ER +EL++ +
Sbjct: 219 KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
+ E D K ++ QV +++ T++ + + K D +N A ++
Sbjct: 279 VIETDLS----KIYEMQKTIQVLQIEKVESTKKMEQLEDKIKD--INKKLSSAENDRDIL 332
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
R VEK +++M+ E L+ + L+ + K M T+K++ A+ +E
Sbjct: 333 RREQEQLNVEK-RQIMEECENLKLECSKLQPSAVKQSDTM---TEKER-ILAQSASVE-- 385
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK----LSNQKVALE 1040
E+ L+Q + + E + L Q + + K+ +E+++K LS +K L+
Sbjct: 386 --EVFRLQQALSDAENEIMRLSS-LNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442
Query: 1041 KQIESLSN 1048
+ L+N
Sbjct: 443 MSLLKLNN 450
>AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1116
Score = 82.6 bits (195), Expect = 7e-15
Identities = 140/708 (19%), Positives = 292/708 (41%), Gaps = 48/708 (6%)
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
D++I + + + +I+ + +++ +N + ++NE +L S L+E CN
Sbjct: 42 DSLIQELETSIKKIITQNQRIKELINIIDQKEDTINE-FQNLKS-LMENTFKCN------ 93
Query: 413 ERIHEISSAVTIDIVKKEN-EL-KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
++ S + ++ E E+ K+ +K C + ++ +L QD P KK +I
Sbjct: 94 DKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVN---ENELQQDEPPAKKGSIHVS 150
Query: 471 ALITQYELSRTDYE---IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
+ IT+ + + E E +R+ + + + E + ++
Sbjct: 151 SAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH 210
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS 586
+EL+ K + + + I L + +KN+E+ + + N++ T S
Sbjct: 211 FQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRS 270
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM---KADILMXXXX 643
N + + ++++ T + +Q S ++ NG E D + + D+L
Sbjct: 271 ITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYL 330
Query: 644 XXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM- 701
++ ++ A+ E+C+E + S+ I+ E+ E +
Sbjct: 331 VSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKG 390
Query: 702 ------RL-QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
RL +K+ + D L EKET + +L + + D ++ + + A+++LT
Sbjct: 391 YKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQ 450
Query: 755 QKDLVEGRIAELESDIRT---EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
+ +I ELE+ + T E++ + F + +D +N
Sbjct: 451 GVTCYKAKIKELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKN 510
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD-DECETCAEYLQERDE 870
K D + + + E++QL L + L LKE +E + E E E L
Sbjct: 511 TK--DLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKEEEEETNRQETEKLKEELSASSA 565
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
+ LK + E+ ++LKE++ + +Q + +V+V DED L + ++ +
Sbjct: 566 RTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEVSVMRDED--KLLRIKINELEKK 622
Query: 931 AEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+ MK TI++L K+ L N K+++A+++Y + K+ K K +ED + L
Sbjct: 623 KNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQYERACKDLNVKEKIIEDMRMTL 677
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
EE +Q E D+ E E +++ + ++ KE LE + + K
Sbjct: 678 EEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNK 725
Score = 72.1 bits (169), Expect = 1e-11
Identities = 180/947 (19%), Positives = 379/947 (40%), Gaps = 71/947 (7%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEM 117
C LK N+I +L K GEL KE+ E + +LI LET + ++ + E+
Sbjct: 8 CLELK--FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSIKKIITQNQRIKEL 65
Query: 118 ENLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
N+ KE N +LK+ + + ++ DT S+LI+ N N EV K+
Sbjct: 66 INIIDQKEDTINEFQNLKSLMENTFKCNDKADT-SSLIINNKLIC-NETVEVPKDSKSKI 123
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
C +K ++ E + + E +I + E+ +S + + + R + ++N
Sbjct: 124 CSERKRVN-ENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEG 182
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE-PNMTMDLDEKLGENNEFETKA 295
R + T+++EL +E+ EL + + L L E N+T+ + + ++N ++
Sbjct: 183 LR-AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN-YDIAI 240
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDN 354
++ ++++ N E+ I K + I+ S+ V + T +D L D+
Sbjct: 241 AEL--HVQKSKNQEQEEKI----MKLSNEIETATRSITNNVSQIKLMHTKIDELRTL-DS 293
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSV-NEKLAS--LNSQLIEKENACNILRIQ 411
+ IDL + + + D N ++L + N+ L S + I++ N N
Sbjct: 294 VSQISNIDLLNLRDLSNGSEED-NLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSS 352
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
E I E + KK ++++E+ ++ KL+ ++ D++ +K D
Sbjct: 353 IEAIWEECKEIVKASSKKSHQIEELEQ----QIEKLQAEVKGYKDENNRLKEKEHKNQDD 408
Query: 472 LITQYE--LSRTDYEIEKEKLRLETG-----TAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
L+ + E + + E++++ + L+ K LE
Sbjct: 409 LLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 468
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL 584
K KL + +++ + L L + L E + L+ ++ KN + L+ K+ KL E
Sbjct: 469 QKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV-KNTK---DLNVKELKLKEE 524
Query: 585 VSTI-NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
++ + N L++ +K L + E+ET E E+ + + + +KAD+
Sbjct: 525 ITQLTNNLQD----MKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 580
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
+ K + ++ ++++ + + LE + +++ R I +L
Sbjct: 581 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 640
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
++Q+ K+ E +YE +D + K +E R + + Q + + ++
Sbjct: 641 KEQLNNQ---------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQV 690
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E + + E+ AT + LG+ L D + S
Sbjct: 691 LEAKLE-EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQ 749
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
+ L+E+++ Q + R KE+ +Y ++R+ R K++ +E
Sbjct: 750 KYNADRKKWLEEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEME 798
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ L E+ +++ + D V E L +++ + D E+E+ KR++
Sbjct: 799 ILTAQLTEK---DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISET 853
Query: 944 EELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ + D+K ++ + FE R ++ED L+
Sbjct: 854 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 900
Score = 56.0 bits (129), Expect = 7e-07
Identities = 109/546 (19%), Positives = 209/546 (38%), Gaps = 43/546 (7%)
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
++ E N + + + K + + +K + E + ++ +L + + G K+ENN L
Sbjct: 339 RIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRL 398
Query: 599 KSLN----DVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
K D + +EKET +L+ Q + LD ++
Sbjct: 399 KEKEHKNQDDLLKEKETLIQQLKEELQ---EKNVTLDVQIQHVVEGKRALSELTQGVTCY 455
Query: 655 XDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF 714
+ K L L+ Q E++ ++LE +I E R + Q+ +Q+ K
Sbjct: 456 KAKIKEL---ETILETQKVERSHS-AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNT 511
Query: 715 IE---KETKLNE----LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
+ KE KL E LTN + +K ++ E++R+ +L + R L+
Sbjct: 512 KDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 571
Query: 768 SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+D++ ++ DE++ L + K S D
Sbjct: 572 ADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 631
Query: 828 SE---VSQLKERLLSCQQE---------LDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + QLKE+L + + E DL + K ++D T E Q + EQ L
Sbjct: 632 MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVL 691
Query: 876 KKEKLSLEQQVSNL---KEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+ + +E+ + L KE+ + Q + NTD + + D + ++E
Sbjct: 692 EAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDV--LGKLTNLQDELQ-ESE 748
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ N K +EE K K M+KY + + F ++ E+E A+L E
Sbjct: 749 QKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKD 808
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQIESLSN 1048
++ EE + L E Q K L + + +E + ++ ++ +E QI +
Sbjct: 809 SDLQKWREERDQLVAAL---EIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKP 865
Query: 1049 TPVSNS 1054
+S++
Sbjct: 866 KRISSA 871
Score = 41.1 bits (92), Expect = 0.021
Identities = 57/290 (19%), Positives = 131/290 (45%), Gaps = 17/290 (5%)
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
+N K + + V E+S +++ L+ +E+ ++ Y E QE++
Sbjct: 195 KNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQE 254
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLHSV----VV 924
E+ +L E + + ++N QI+ ++ V+ ++ D NL +
Sbjct: 255 EKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEE 314
Query: 925 DRM-SYDAEVEKNKRLM-KTIEELRYKKQDLKNTV-TKMQKAMEKYTKKDKEFEAKRKEL 981
D + + ++ N L+ K ++E R ++ + +N+ + ++ E+ + K K ++
Sbjct: 315 DNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQI 374
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVALE 1040
E+ + ++E+L+ K +E E K+ + Q LKE + + ++ ++L + V L+
Sbjct: 375 EELEQQIEKLQAEVKGYKDENNRLKE--KEHKNQDDLLKEKETLIQQLKEELQEKNVTLD 432
Query: 1041 KQIESL--SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM-NAKL 1087
QI+ + +S T V A ++ + + E QK+++ +AKL
Sbjct: 433 VQIQHVVEGKRALSELTQGVTCYKAKIKE---LETILETQKVERSHSAKL 479
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 697 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 754
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 755 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 814
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 815 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 868
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 869 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 922
>AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin heavy
chain SM1 protein.
Length = 622
Score = 82.6 bits (195), Expect = 7e-15
Identities = 111/550 (20%), Positives = 218/550 (39%), Gaps = 29/550 (5%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ LEE + E LT+ Y+ K + L +E+D L + + + + +L
Sbjct: 38 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 97
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
+K K +L++ + + + + REKET+A L R+ + + EL++
Sbjct: 98 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 157
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
M L + AL+ Q EE LE ++ E A++
Sbjct: 158 ---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED-AKL 213
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
+ + M+ K E D ++ + NE K L+R +LE R+
Sbjct: 214 RLEVNMQALKGQFERD---LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAA 268
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
K +EG + +LE + D R+L E+ +
Sbjct: 269 KKKLEGDLKDLE----------LQADSAIKGREEAIKHVRKLQAQMKDFQREL-EDARAS 317
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + L+ L+ Q++L + K+ D E E AE L L
Sbjct: 318 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 377
Query: 876 KKEKLSLEQQVSNLKEQIRTQQP-----VERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
+ EK LE +++ L+E++ +Q +R K A + A S S
Sbjct: 378 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 437
Query: 931 AEVEK-NKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKK-DKEFEAKRKELEDCKAE 987
++E+ NK L + E+ K K+T+ ++ + + ++ ++E K+ + K +
Sbjct: 438 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 497
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SL 1046
++LK+ ++++E + +Y +Q E+ R+K+ K LE ++ S + A ++++ L
Sbjct: 498 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 557
Query: 1047 SNTPVSNSTM 1056
SN M
Sbjct: 558 DEATESNEAM 567
Score = 56.4 bits (130), Expect = 5e-07
Identities = 111/570 (19%), Positives = 237/570 (41%), Gaps = 42/570 (7%)
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQ 612
L+EE++A + + LS+ KL + ST+ L+E + + +T++ E +
Sbjct: 2 LNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 61
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
A+ ++ + + ELD + D+ ++ + +Q LA ++
Sbjct: 62 AAAYDKLEKTKNRLQQELDDLVVDL--------DNQRQLVSNLEKKQRKFDQLLAEEKNI 113
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK 732
K D R + EK + + + L++ ++ ++L E+ K+ L + E L
Sbjct: 114 SSKYAD-ERDRAEAEAREKETKALS-LARALEEALEAKEEL--ERTNKM--LKAEMEDLV 167
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
D K++ ++ L TQ + ++ ++ ELE +++ + A +
Sbjct: 168 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 227
Query: 793 XXXXXXXTFGDENR-----DLGE-NPKLDDSPK-RSISVISDSEVS-QLKERLLSCQQEL 844
+E R L E +L+D K R+++ + ++ LK+ L +
Sbjct: 228 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 287
Query: 845 DDLKERYK---ELDDECETCAEYLQE----RDEQCARLK---KEKLSLEQQVSNLKEQIR 894
+E K +L + + L++ RDE A K K+ SLE + L+E +
Sbjct: 288 KGREEAIKHVRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 347
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDL 953
ER K AD+ +E L S + R + E + R+ + EEL ++ ++
Sbjct: 348 A---AERARKQADL--EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 402
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE 1013
+ +++KA ++ + E +R + ++ ++L+++ KEL + +K +
Sbjct: 403 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 462
Query: 1014 EQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
+ EAKIA E V++ + +K A K ++ + + + V + + Q
Sbjct: 463 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKE 520
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANR 1101
K N ++K++ +L ++ + ANR
Sbjct: 521 QAEKGNARVKQLKRQLEEAEEESQRINANR 550
Score = 49.6 bits (113), Expect = 6e-05
Identities = 109/548 (19%), Positives = 210/548 (38%), Gaps = 52/548 (9%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
S +++LE KEI+NLT + K+ ++L++ + L + + V + DN + V
Sbjct: 35 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 94
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS 229
+L+K Q + EK ++ +K + A+ + +E ++L + L +
Sbjct: 95 NLEKKQRKFDQLLAE-EKNIS---SKYADERDRAEAEAREKETKALSLA-----RALEEA 145
Query: 230 ISDSNTSTRYNKICTLQSE-LDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN 288
+ R NK+ + E L + ++D + + K LE M L+E E
Sbjct: 146 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 205
Query: 289 NEFETKAVK-------VMSEIKRNLNSLSEQLINNESKK---------SKDHIDRYKDSL 332
E ++ + + +R+L + EQ N E ++ + D K
Sbjct: 206 QATEDAKLRLEVNMQALKGQFERDLQARDEQ--NEEKRRQLQRQLHEYETELEDERKQRA 263
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
LA + L E+ D+ I +E ++ K+Q + + EL+
Sbjct: 264 LAAAAKKKLEGDLKDLELQADSAIK----GREEAIKHVRKLQAQMKDFQRELEDARASRD 319
Query: 393 SLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENEL-KEILTKECLKLSKLKIDI 451
+ + E E L ++ E +A + +K+ +L KE L +E S L
Sbjct: 320 EIFATAKENEKKAKSLEADLMQLQEDLAAA--ERARKQADLEKEELAEEL--ASSLS--- 372
Query: 452 PRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVX---XXXXXXX 508
R+ QD +++ L + E + + E +++R T A+ +
Sbjct: 373 GRNALQD--EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 430
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL-IKILSEEIDALKIAIAKN 567
LE + E++S E+ KSK A L I L E+++ +
Sbjct: 431 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ---EAREK 487
Query: 568 EEKMLSLSEKDNKLTELVSTING---LKEENNSLKSLNDVITREKETQASELERSCQVIK 624
+ SL +KD KL E++ + + E+ + ++ + Q E E Q I
Sbjct: 488 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 547
Query: 625 QNGFELDK 632
N +L +
Sbjct: 548 ANRRKLQR 555
Score = 47.6 bits (108), Expect = 2e-04
Identities = 99/593 (16%), Positives = 214/593 (36%), Gaps = 37/593 (6%)
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEI 436
LNE +++ +++LN QL + + E + E +I + +E
Sbjct: 2 LNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 61
Query: 437 LTKECLKLSKLKIDIPRDLDQ---DLPAHKKITI-------LFDALITQYELSRTDYEIE 486
KL K K + ++LD DL +++ FD L+ + + + Y E
Sbjct: 62 AAAYD-KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 120
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
+++ E + + LE + +K+ E+L K V +N
Sbjct: 121 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHE 179
Query: 547 LNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDV 604
L K L +++ +K + + E+++ + + +L + + G E + + N+
Sbjct: 180 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 239
Query: 605 ITREKETQASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
R+ + Q E E + KQ K++ D+ +
Sbjct: 240 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRK 299
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
L Q + + E+ + K +EK A+ +M+LQ+ + ++ + + +
Sbjct: 300 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 359
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TAT 777
EL ++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 360 KEELA--------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 405
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKER 836
+ +N + + + RS + + + S+ K
Sbjct: 406 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 465
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ + + ++ L+E+ ++ E + + L+++D++ + + + KEQ
Sbjct: 466 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 525
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
+Q K + N + + R D E N+ + + + L+ K
Sbjct: 526 NARVKQLKRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 577
Score = 32.3 bits (70), Expect = 9.9
Identities = 32/154 (20%), Positives = 70/154 (45%), Gaps = 9/154 (5%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMC--QSLKESSNEINLKLEKLSGELFD 83
QL+ + +E S+ ++ +S ++ +S + + +LE+ + EL
Sbjct: 390 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 449
Query: 84 -IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E + A++ K+++ I L ++I LE + + +E + T SLK K KK+ E
Sbjct: 450 KLHEMEGAVKSKFKSTIAA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 503
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
+ + + + + +++ N V LK+ E
Sbjct: 504 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 537
>AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin heavy
chain SM2 protein.
Length = 588
Score = 82.6 bits (195), Expect = 7e-15
Identities = 111/550 (20%), Positives = 218/550 (39%), Gaps = 29/550 (5%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ LEE + E LT+ Y+ K + L +E+D L + + + + +L
Sbjct: 38 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 97
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
+K K +L++ + + + + REKET+A L R+ + + EL++
Sbjct: 98 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 157
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
M L + AL+ Q EE LE ++ E A++
Sbjct: 158 ---MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED-AKL 213
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
+ + M+ K E D ++ + NE K L+R +LE R+
Sbjct: 214 RLEVNMQALKGQFERD---LQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAA 268
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
K +EG + +LE + D R+L E+ +
Sbjct: 269 KKKLEGDLKDLE----------LQADSAIKGREEAIKHVRKLQAQMKDFQREL-EDARAS 317
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + L+ L+ Q++L + K+ D E E AE L L
Sbjct: 318 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 377
Query: 876 KKEKLSLEQQVSNLKEQIRTQQP-----VERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
+ EK LE +++ L+E++ +Q +R K A + A S S
Sbjct: 378 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 437
Query: 931 AEVEK-NKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTKK-DKEFEAKRKELEDCKAE 987
++E+ NK L + E+ K K+T+ ++ + + ++ ++E K+ + K +
Sbjct: 438 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 497
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE-SL 1046
++LK+ ++++E + +Y +Q E+ R+K+ K LE ++ S + A ++++ L
Sbjct: 498 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 557
Query: 1047 SNTPVSNSTM 1056
SN M
Sbjct: 558 DEATESNEAM 567
Score = 56.4 bits (130), Expect = 5e-07
Identities = 111/570 (19%), Positives = 237/570 (41%), Gaps = 42/570 (7%)
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQ 612
L+EE++A + + LS+ KL + ST+ L+E + + +T++ E +
Sbjct: 2 LNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 61
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
A+ ++ + + ELD + D+ ++ + +Q LA ++
Sbjct: 62 AAAYDKLEKTKNRLQQELDDLVVDL--------DNQRQLVSNLEKKQRKFDQLLAEEKNI 113
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK 732
K D R + EK + + + L++ ++ ++L E+ K+ L + E L
Sbjct: 114 SSKYAD-ERDRAEAEAREKETKALS-LARALEEALEAKEEL--ERTNKM--LKAEMEDLV 167
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
D K++ ++ L TQ + ++ ++ ELE +++ + A +
Sbjct: 168 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 227
Query: 793 XXXXXXXTFGDENR-----DLGE-NPKLDDSPK-RSISVISDSEVS-QLKERLLSCQQEL 844
+E R L E +L+D K R+++ + ++ LK+ L +
Sbjct: 228 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 287
Query: 845 DDLKERYK---ELDDECETCAEYLQE----RDEQCARLK---KEKLSLEQQVSNLKEQIR 894
+E K +L + + L++ RDE A K K+ SLE + L+E +
Sbjct: 288 KGREEAIKHVRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 347
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDL 953
ER K AD+ +E L S + R + E + R+ + EEL ++ ++
Sbjct: 348 A---AERARKQADL--EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 402
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE 1013
+ +++KA ++ + E +R + ++ ++L+++ KEL + +K +
Sbjct: 403 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 462
Query: 1014 EQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
+ EAKIA E V++ + +K A K ++ + + + V + + Q
Sbjct: 463 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYKE 520
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKTGANR 1101
K N ++K++ +L ++ + ANR
Sbjct: 521 QAEKGNARVKQLKRQLEEAEEESQRINANR 550
Score = 49.6 bits (113), Expect = 6e-05
Identities = 109/548 (19%), Positives = 210/548 (38%), Gaps = 52/548 (9%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
S +++LE KEI+NLT + K+ ++L++ + L + + V + DN + V
Sbjct: 35 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 94
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS 229
+L+K Q + EK ++ +K + A+ + +E ++L + L +
Sbjct: 95 NLEKKQRKFDQLLAE-EKNIS---SKYADERDRAEAEAREKETKALSLA-----RALEEA 145
Query: 230 ISDSNTSTRYNKICTLQSE-LDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGEN 288
+ R NK+ + E L + ++D + + K LE M L+E E
Sbjct: 146 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 205
Query: 289 NEFETKAVK-------VMSEIKRNLNSLSEQLINNESKK---------SKDHIDRYKDSL 332
E ++ + + +R+L + EQ N E ++ + D K
Sbjct: 206 QATEDAKLRLEVNMQALKGQFERDLQARDEQ--NEEKRRQLQRQLHEYETELEDERKQRA 263
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
LA + L E+ D+ I +E ++ K+Q + + EL+
Sbjct: 264 LAAAAKKKLEGDLKDLELQADSAIK----GREEAIKHVRKLQAQMKDFQRELEDARASRD 319
Query: 393 SLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENEL-KEILTKECLKLSKLKIDI 451
+ + E E L ++ E +A + +K+ +L KE L +E S L
Sbjct: 320 EIFATAKENEKKAKSLEADLMQLQEDLAAA--ERARKQADLEKEELAEEL--ASSLS--- 372
Query: 452 PRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVX---XXXXXXX 508
R+ QD +++ L + E + + E +++R T A+ +
Sbjct: 373 GRNALQD--EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 430
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL-IKILSEEIDALKIAIAKN 567
LE + E++S E+ KSK A L I L E+++ +
Sbjct: 431 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ---EAREK 487
Query: 568 EEKMLSLSEKDNKLTELVSTING---LKEENNSLKSLNDVITREKETQASELERSCQVIK 624
+ SL +KD KL E++ + + E+ + ++ + Q E E Q I
Sbjct: 488 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 547
Query: 625 QNGFELDK 632
N +L +
Sbjct: 548 ANRRKLQR 555
Score = 47.6 bits (108), Expect = 2e-04
Identities = 99/593 (16%), Positives = 214/593 (36%), Gaps = 37/593 (6%)
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEI 436
LNE +++ +++LN QL + + E + E +I + +E
Sbjct: 2 LNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 61
Query: 437 LTKECLKLSKLKIDIPRDLDQ---DLPAHKKITI-------LFDALITQYELSRTDYEIE 486
KL K K + ++LD DL +++ FD L+ + + + Y E
Sbjct: 62 AAAYD-KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 120
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
+++ E + + LE + +K+ E+L K V +N
Sbjct: 121 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHE 179
Query: 547 LNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS-LNDV 604
L K L +++ +K + + E+++ + + +L + + G E + + N+
Sbjct: 180 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 239
Query: 605 ITREKETQASELERSCQ-VIKQNGFEL---DKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
R+ + Q E E + KQ K++ D+ +
Sbjct: 240 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRK 299
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
L Q + + E+ + K +EK A+ +M+LQ+ + ++ + + +
Sbjct: 300 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 359
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ---TAT 777
EL ++L SS N L +K +E RIA+LE ++ EQ A
Sbjct: 360 KEELA--------------EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 405
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS-ISVISDSEVSQLKER 836
+ +N + + + RS + + + S+ K
Sbjct: 406 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 465
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ + + ++ L+E+ ++ E + + L+++D++ + + + KEQ
Sbjct: 466 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 525
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
+Q K + N + + R D E N+ + + + L+ K
Sbjct: 526 NARVKQLKRQLEEAEEESQRINANRRKLQR-ELDEATESNEAMGREVNALKSK 577
Score = 32.3 bits (70), Expect = 9.9
Identities = 32/154 (20%), Positives = 70/154 (45%), Gaps = 9/154 (5%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMC--QSLKESSNEINLKLEKLSGELFD 83
QL+ + +E S+ ++ +S ++ +S + + +LE+ + EL
Sbjct: 390 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 449
Query: 84 -IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E + A++ K+++ I L ++I LE + + +E + T SLK K KK+ E
Sbjct: 450 KLHEMEGAVKSKFKSTIAA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 503
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
+ + + + + +++ N V LK+ E
Sbjct: 504 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 537
>AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1044
Score = 81.4 bits (192), Expect = 2e-14
Identities = 211/1060 (19%), Positives = 418/1060 (39%), Gaps = 117/1060 (11%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L+E +LE L +L +KE+ + GK + I+ + ++ M+Q+ L
Sbjct: 32 LQERCGLYKSELEILKEKLRQLKEENN--NGKEKLRIMAVKNSEV-MAQLTESRQSILKL 88
Query: 123 DKEIKNLTDSLKTKSKKINELQE-------ENDTLS---NLIMENVTESDNLNKEVDDLK 172
+ E++N + L+ K +NE +E +N+ L I + E +L K + L
Sbjct: 89 ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 148
Query: 173 KNNECLTQKCI----DLEKLVNESENKIG----PKNICAQCKLK----ENLIQSLHIGYD 220
E K + N+ + IG K + ++ ++K E IQ LH
Sbjct: 149 LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL- 207
Query: 221 NTLSKLNRSISDSNTSTRYNKICTLQSE-LDAGREDCKELCEDFT--SIKNHLELHEPNM 277
T ++L++S+ N S +K+ +L++E + G E +D ++ E +
Sbjct: 208 -TANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 266
Query: 278 TMDLDEKLGE--NNEFETKAVKV-MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
++E + E E +KV M+ + E+L+ S SK
Sbjct: 267 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSK------------ 314
Query: 335 VLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASL 394
L++E + + + L+E + Y+ + E EL NEK+ SL
Sbjct: 315 -LESEMTKKCSQLLTL---------EKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL 364
Query: 395 NSQL-IEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
+ + E E C + E+ +I ++ K+ L+ L K+ + + + +
Sbjct: 365 ETNINTEHEKIC----LAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSM 420
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEK-EKLRLETGTAKAVXXXXXXXXXXXX 512
L QD+ + D L+T+ + ++K E L+
Sbjct: 421 -LQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE 479
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKI----LSEEIDALKIAIAKNE 568
+ L N+++ E+ K K K +E +KI L E + I +
Sbjct: 480 ICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ 539
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
++ L ++ + EL T L+++ + L + +++E+ A +L + + +
Sbjct: 540 QQQQMLQQETIRNGELEDTQTKLEKQ---VSKLEQELQKQRESSAEKLRKMEEKCESAAH 596
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E D + ++ +E + ++ + LK E K S+L++ I
Sbjct: 597 EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDM-ILD 655
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
KT E++ + ++E +KL ET+L E K E L+ + A +L+S+
Sbjct: 656 QTKT-ELEKKT-----NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST--- 706
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
+ QL +D+++ LE T + T + N +L
Sbjct: 707 LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL 766
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
+ + + + +++++++ + L+ + KE + + E+ + LQ
Sbjct: 767 KQRA----AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNA 822
Query: 869 DEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
EQ + L EQ++S LK++I RTQQ ++ + SV+ ++
Sbjct: 823 KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE-----------------MESVMKEQE 865
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
Y A + K + +ELR ++ ++N+ T++ +A + + +E E ELED
Sbjct: 866 QYIAT--QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED---- 919
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLS 1047
+KQ KE D AE L + + L EA++ EI KLS + +L++
Sbjct: 920 ---MKQLSKEKDAHGNHLAEELGASKVREAHL-EARMQAEI-KKLSAEVESLKEAYHMEM 974
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ N + I + Q + V + N++L+K +L
Sbjct: 975 ISHQENHAKW-----KISADSQKSSVQQLNEQLEKAKLEL 1009
Score = 70.9 bits (166), Expect = 2e-11
Identities = 128/608 (21%), Positives = 257/608 (42%), Gaps = 62/608 (10%)
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
LI+I +E D LK+ +A + + E+ L E S N K E+ K + ++T E
Sbjct: 277 LIQIEAENSD-LKVNMAHRTSQFQLIQEE---LLEKAS--NSSKLESEMTKKCSQLLTLE 330
Query: 609 KETQASELERSCQVIKQNGFELDKMKAD--ILMXXXXXXXXXXXXXXXXDEAKSL-LEQN 665
K+ + + S K E + M+ + I ++AK + LEQ+
Sbjct: 331 KQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQH 390
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN-EL 724
+++Q E + + K EKT + + I+ Q ++ D+L E + ++ E
Sbjct: 391 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 450
Query: 725 TNKYEALKR------DYDAAVKDLESSREAVNQ-LTTQKDLVEGRIAELESDIRTEQTAT 777
K EALK + V+ L+S+ E + L + +EG + E ++ +
Sbjct: 451 MKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 510
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFG---DENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
+ + + + + + + +VS+L+
Sbjct: 511 YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE 570
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQQVSNL- 889
+ L Q++ + E+ ++++++CE+ A + ++ L ++ K+ ++Q L
Sbjct: 571 QEL---QKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 627
Query: 890 ---KEQIRTQQPVERQAK-FADVAVNTDEDWANLHSVV-----VDRMSYDAEVEKNKRLM 940
KE + ++ E +A + + + D+ L ++++ + E E + L
Sbjct: 628 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQ 687
Query: 941 K--TIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-------RKELEDCKAELEE 990
K +E EL+ +LK+T+ ++Q+ + K E K EL +CK E+E+
Sbjct: 688 KREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIED 747
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRL----KEAKIALE-IVDKLSN--QKVALE--- 1040
KQ E+D+ + LKQR Q L +E + +E + KL +K LE
Sbjct: 748 KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE 807
Query: 1041 --KQIESLSNTPVSNSTMYVATGSAI-VQN-QQITDVMKENQKLKKMNAKLITICKKRGK 1096
KQIESL N + N+ + I +QN Q+I+ + KE ++ ++ ++ ++ K++ +
Sbjct: 808 CNKQIESL-NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 866
Query: 1097 TGANRENE 1104
A + E
Sbjct: 867 YIATQYKE 874
Score = 51.6 bits (118), Expect = 2e-05
Identities = 119/581 (20%), Positives = 234/581 (40%), Gaps = 76/581 (13%)
Query: 76 KLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
++S E +++ SALE + L+L L + E + K +E+ L LK
Sbjct: 463 QVSEETIKVRQLDSALEICKEELVLHLNQ---LEGNKEKFEKQLKKKSEEVYCLQKELKI 519
Query: 136 KSKKINELQEENDTLSNLIMEN--VTESDNL-NKEVDDLKKNNECLTQKCI-DLEKLVNE 191
K+ + E E+N L + + + + + + + N E++D + E K +L+K
Sbjct: 520 KNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRES 579
Query: 192 SENKIGP-----KNICAQCKLKENLIQSLH----------IGYDNTLSKLNRSISDSNTS 236
S K+ ++ + LK + L Y LSK+ + I
Sbjct: 580 SAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 639
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
NK L S+LD + K E T+ LE + + +L E L + ET+
Sbjct: 640 GE-NKAMHL-SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQ 697
Query: 297 KVMSEIKRNLNSLSE--------QL-----------INNESKKSKDHIDRYKDSLL---- 333
E+K L L E QL + E ++ K I+ K LL
Sbjct: 698 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ 757
Query: 334 AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYT----KVQGDLNECTSELKSVNE 389
A+ + + +D I +++ ++++ + K K + +L EC +++S+N+
Sbjct: 758 ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND 817
Query: 390 KLASLNSQLIEKE-----NACNILRIQKERIHEISSAVTIDIVKKENE------LKEIL- 437
KL + QL EKE N I +++KE ++ V KE E KE +
Sbjct: 818 KLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAID 877
Query: 438 TKECLKLSKLKI-----DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRL 492
+ L+L++ ++ ++ Q + A ++I L L +LS+ + + L
Sbjct: 878 LGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSK-EKDAHGNHLAE 936
Query: 493 ETGTAKA----VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
E G +K + ++L+EA++ H+E +K D ++
Sbjct: 937 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSS-- 994
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
++ L+E+++ K+ + + ++ + +L ++ E++ N
Sbjct: 995 -VQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAAN 1034
Score = 35.5 bits (78), Expect = 1.1
Identities = 44/219 (20%), Positives = 94/219 (42%), Gaps = 15/219 (6%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVER 901
++L+ ++ + L+ C + + E+C K E L++++ LKE+
Sbjct: 6 EKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENN-----NG 60
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
+ K +AV E A L + ++E+E +++ L + ++LK V
Sbjct: 61 KEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQN 120
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY----LKQREEQCK 1017
E+ +E E+ R EL + + +L + +EL ++Y +E++C
Sbjct: 121 ---ERLDLCQQEIESSRVELRSLEKIISQLPLK-RELFGFKSYLSKYQMSSFSNKEDRCI 176
Query: 1018 RLKEAK--IALEIVDKLSNQKVALEKQIESLSNTPVSNS 1054
EA + E+ KL+ ++ ++K +L+ +S S
Sbjct: 177 GCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQS 215
>AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1454
Score = 81.4 bits (192), Expect = 2e-14
Identities = 230/1080 (21%), Positives = 433/1080 (40%), Gaps = 119/1080 (11%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L ++ + K E + EL + + S LE Q + + +L QI +LE E +
Sbjct: 130 LVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQ----QAASVPILEEQIINLEAEVSAQ 185
Query: 123 DKEIKNLTDSLKTKSKKINE----LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
DK ++ + L+ K + E LQE + L ++ + E K + ++ NE L
Sbjct: 186 DKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVD-LLEQTKQGKRAE--RQRNEAL 242
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+L K + + K+ K Q + +E L ++L K N+ + +
Sbjct: 243 -YNAEELSKAFQQYKKKVAEKLEKVQAE-EEILERNL-----TNCEKENKRLQER----- 290
Query: 239 YNKICTL-QSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
C L +SEL+ +E ++L E+ + K L + M + E + + E +K
Sbjct: 291 ----CGLYKSELEILKEKLRQLKEENNNGKEKLRI----MAVKNSEVMAQLTESRQSILK 342
Query: 298 VMSEIKRNLNSLSEQL-INNESKKSKDHIDRYKDSL-LAVLDAEFGTTSLDVFEILMDNI 355
+ SE++ L ++ + NE+++ K + + L L + E L E ++ +
Sbjct: 343 LESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQL 402
Query: 356 INKYQI-DLDEILEKY--TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
K ++ L KY + + C ++ ++ L +L KE L
Sbjct: 403 PLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL 462
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
S +T + ++ ++L + T E +KL +++ +D +Q +K+ L
Sbjct: 463 TANQLSQSLITCNDSQESSKLSSLET-EPVKLGGHQVESVKDQNQHT-MNKQYEKERQRL 520
Query: 473 ITQYELSRTDY-EIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
+T E RT +IE E L+ A + LE+A N K L E
Sbjct: 521 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE-------ELLEKASNSSK-LESE 572
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
+TK + + L L K L E+I A AKN E L EK+ K+ L + IN
Sbjct: 573 MTK-------KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTE 625
Query: 592 KEE----NNSLKSLNDVITREKETQ----ASELERSCQVIKQNGFELDKMKADILMXXXX 643
E+ K ++ +E E Q ++LE+ Q K+ + ++ DI+
Sbjct: 626 HEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 685
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI-QNRMIMR 702
E K ++N+ E + S I ++ + EI + +++
Sbjct: 686 LESLDRLLTESKGEMK---KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLH 742
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG- 761
L + +K + + K E+ + LK + + E + + L Q+ +++
Sbjct: 743 LNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQE 802
Query: 762 --RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPK 819
R ELE D +T+ V + + E+ + K
Sbjct: 803 TIRNGELE-DTQTKLEKQVSKLEQELQKQRESSAEKLR------KMEEKCESAAHEADLK 855
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
R + Q+K + ++EL +++ L + E A +L + D L + K
Sbjct: 856 RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLD---MILDQTK 912
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKR 938
LE++ + +KE + Q E + L + R + E++ +
Sbjct: 913 TELEKKTNAVKELEKLQHSTETE----------------LTEALQKREVLETELQNAHGE 956
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L T+ +L Q+L++ + K Q ++E+ K+ A EL +CK E+E+ KQ E+
Sbjct: 957 LKSTLRQL----QELRDVLQKAQLSLEEKYTTIKDLTA---ELRECKMEIEDKKQELLEM 1009
Query: 999 DEECETCAEYLKQREEQCKRL----KEAKIALE-IVDKLSN--QKVALE-----KQIESL 1046
D+ + LKQR Q L +E + +E + KL +K LE KQIESL
Sbjct: 1010 DQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESL 1069
Query: 1047 SNTPVSNSTMYVATGSAI-VQN-QQITDVMKENQKLKKMNAKLITICKKRGKTGANRENE 1104
N + N+ + I +QN Q+I+ + KE ++ ++ ++ ++ K++ + A + E
Sbjct: 1070 -NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKE 1128
Score = 79.4 bits (187), Expect = 7e-14
Identities = 207/1056 (19%), Positives = 424/1056 (40%), Gaps = 110/1056 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L+E +LE L +L +KE+ + GK + I+ + ++ M+Q+ L
Sbjct: 287 LQERCGLYKSELEILKEKLRQLKEENN--NGKEKLRIMAVKNSEV-MAQLTESRQSILKL 343
Query: 123 DKEIKNLTDSLKTKSKKINELQE-------ENDTLS---NLIMENVTESDNLNKEVDDLK 172
+ E++N + L+ K +NE +E +N+ L I + E +L K + L
Sbjct: 344 ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 403
Query: 173 KNNECLTQKCI----DLEKLVNESENKIG----PKNICAQCKLK----ENLIQSLHIGYD 220
E K + N+ + IG K + ++ ++K E IQ LH
Sbjct: 404 LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL- 462
Query: 221 NTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD 280
T ++L++S+ N S +K+ +L++E +K L H+ D
Sbjct: 463 -TANQLSQSLITCNDSQESSKLSSLETE----------------PVK--LGGHQVESVKD 503
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSE-QLINNESKKSKDH-IDRYKDSLLAVLDA 338
++ N ++E + ++++ I+ L + + N++ K + H +++ +L+
Sbjct: 504 QNQHT-MNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 562
Query: 339 EFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL 398
++ L+ + + + L+E + Y+ + E EL NEK+ SL + +
Sbjct: 563 ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNI 622
Query: 399 -IEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E E C + E+ +I ++ K+ L+ L K+ + + + + L Q
Sbjct: 623 NTEHEKIC----LAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSM-LQQ 677
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEK-EKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
D+ + D L+T+ + ++K E L+ +
Sbjct: 678 DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKE 737
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKI----LSEEIDALKIAIAKNEEKML 572
L N+++ E+ K K K +E +KI L E + I +++
Sbjct: 738 ELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQ 797
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L ++ + EL T L+++ + L + +++E+ A +L + + + E D
Sbjct: 798 MLQQETIRNGELEDTQTKLEKQ---VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADL 854
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
+ ++ +E + ++ + LK E K S+L++ I KT
Sbjct: 855 KRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDM-ILDQTKT 913
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E++ + ++E +KL ET+L E K E L+ + A +L+S+ + QL
Sbjct: 914 -ELEKKT-----NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST---LRQL 964
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+D+++ LE T + T + N +L +
Sbjct: 965 QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRA 1024
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ + + +++++++ + L+ + KE + + E+ + LQ EQ
Sbjct: 1025 ----AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL 1080
Query: 873 ARLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ L EQ++S LK++I RTQQ ++ + SV+ ++ Y A
Sbjct: 1081 REKEFIMLQNEQEISQLKKEIERTQQRMKE-----------------MESVMKEQEQYIA 1123
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
+ K + +ELR ++ ++N+ T++ +A + + +E E ELED +
Sbjct: 1124 T--QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED-------M 1174
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPV 1051
KQ KE D AE L + + L EA++ EI KLS + +L++ +
Sbjct: 1175 KQLSKEKDAHGNHLAEELGASKVREAHL-EARMQAEI-KKLSAEVESLKEAYHMEMISHQ 1232
Query: 1052 SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
N + I + Q + V + N++L+K +L
Sbjct: 1233 ENHAKW-----KISADSQKSSVQQLNEQLEKAKLEL 1263
Score = 44.4 bits (100), Expect = 0.002
Identities = 46/214 (21%), Positives = 91/214 (42%), Gaps = 13/214 (6%)
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
S S D E+ L+E+L +Q+ L + L + E+ L + + + L+ +
Sbjct: 104 SSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQ 163
Query: 881 S------LEQQVSNLKEQIRTQQPVERQAK-----FADVAVNTDEDWANLHSVVVD-RMS 928
LE+Q+ NL+ ++ Q V R+A+ + + ++ + ++
Sbjct: 164 QAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVD 223
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EKYTKKDKEFEAKRKELEDCKAE 987
+ ++ KR + E Y ++L + +K + EK K E E + L +C+ E
Sbjct: 224 LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKE 283
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
+ L++R E E E L+Q +E+ KE
Sbjct: 284 NKRLQERCGLYKSELEILKEKLRQLKEENNNGKE 317
>AK024959-1|BAB15043.1| 696|Homo sapiens protein ( Homo sapiens cDNA:
FLJ21306 fis, clone COL02125. ).
Length = 696
Score = 81.0 bits (191), Expect = 2e-14
Identities = 112/528 (21%), Positives = 222/528 (42%), Gaps = 34/528 (6%)
Query: 517 TLEEAHNEVKSLHE-ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
TL + +++S ++ + +L+ K ++K LS EI+ +I N ++ +
Sbjct: 139 TLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMK-LSNEIETATRSITNNVSQIKLMH 197
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK-MK 634
K ++L L S + N L +L D+ +E + + N + + K +K
Sbjct: 198 TKIDELRTLDSVS---QISNIDLLNLRDLSNGSEEDNLPNTQLD---LLGNDYLVSKQVK 251
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAE 694
+ +E K +++ + Q EE + +L+ +K ++ +
Sbjct: 252 EYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYK---D 308
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
NR+ R K D L EKET + +L + + D ++ + + A+++LT
Sbjct: 309 ENNRLKEREHKN---QDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQ 365
Query: 755 QKDLVEGRIAELESDIRT---EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
+ +I ELE+ + T E++ + F + +D +N
Sbjct: 366 GVTCYKAKIKELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKN 425
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD-DECETCAEYLQERDE 870
K D + + + E++QL L + L LKE +E + E E E L
Sbjct: 426 TK--DLNVKELKL--KEEITQLTNNLQDMKHLLQ-LKEEEEETNRQETEKLKEELSASSA 480
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
+ LK + E+ ++LKE++ + +Q + +V+V DED L + ++ +
Sbjct: 481 RTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-KEVSVMRDED--KLLRIKINELEKK 537
Query: 931 AEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+ MK TI++L K+ L N K+++A+++Y + K+ K K +ED + L
Sbjct: 538 KNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAIQQYERACKDLNVKEKIIEDMRMTL 592
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
EE +Q E D+ E E +++ + ++ KE LE + + K
Sbjct: 593 EEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNK 640
Score = 66.1 bits (154), Expect = 7e-10
Identities = 92/472 (19%), Positives = 196/472 (41%), Gaps = 42/472 (8%)
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
++ E N + + + K + + +K + E + ++ +L + + G K+ENN L
Sbjct: 254 RIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRL 313
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K RE + Q L+ +I+Q EL + + + +
Sbjct: 314 KE------REHKNQDDLLKEKETLIQQLKEELQEKNVTLDV-----------------QI 350
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
+ ++E AL E + T C + +I ++T +T +++ +L++ I E + + ++
Sbjct: 351 QHVVEGKRALSELTQGVT--CYKAKIKELETILETQKVERSHSAKLEQDILEKESIILKL 408
Query: 718 ETKLNELTNKYE-ALKRDYDAAVKDLESSREAV---NQLTTQKDLVEGRIAELESDIRTE 773
E L E + ++K D VK+L+ E N L K L++ + E E++ +
Sbjct: 409 ERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQET 468
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE---- 829
+ + D L + K ++ +SV+ D +
Sbjct: 469 EKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 528
Query: 830 --VSQLKERLLSCQQELDDLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQ 885
+++L+++ C QELD + ++L ++ + E +Q+ + C L ++ +E
Sbjct: 529 IKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDM 588
Query: 886 VSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEE 945
L+EQ +TQ VE Q + + + E A ++ + D E + N+R K E
Sbjct: 589 RMTLEEQEQTQ--VE-QDQVLEAKLEEVERLATELEKWKEKCN-DLETKNNQRSNKEHEN 644
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
L N ++Q++ +KY K++ ++ L E E ++++ K+
Sbjct: 645 NTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRKKKKK 696
Score = 44.8 bits (101), Expect = 0.002
Identities = 114/589 (19%), Positives = 252/589 (42%), Gaps = 72/589 (12%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L+E++ + L + EL + KE+K+ L + I+ +Q ++L +S E +NLT
Sbjct: 91 LQENNEGLRAFLLTIENELKNEKEEKAELNKQ----IVHSQ-QELSLS-----EKKNLTL 140
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
KE++ + + +++ + +N IM+ E + + + + + + K
Sbjct: 141 SKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKI 200
Query: 183 IDLEKLVNESE-NKIGPKNI--CAQCKLKENL--IQSLHIGYDNTLSKLNRSISDSNTST 237
+L L + S+ + I N+ + ++NL Q +G D +SK +
Sbjct: 201 DELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEP-- 258
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
N+ + S ++A E+CKE+ + +S K+H + E E + K
Sbjct: 259 --NRENSFHSSIEAIWEECKEIVK-ASSKKSH-----------------QIEELEQQIEK 298
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+ +E+K + + K++D + + K++L+ L E ++ ++ + +++
Sbjct: 299 LQAEVKGYKD--ENNRLKEREHKNQDDLLKEKETLIQQLKEELQEKNV-TLDVQIQHVVE 355
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSEL---KSVNEKLASLNSQLIEKENACNILRIQKER 414
+ L E+ + T + + E + L K A L ++EKE+ IL++++
Sbjct: 356 GKRA-LSELTQGVTCYKAKIKELETILETQKVERSHSAKLEQDILEKESI--ILKLER-N 411
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
+ E + D VK +L +K KLK +I + L +L K + L +
Sbjct: 412 LKEFQEHLQ-DSVKNTKDLN-------VKELKLKEEITQ-LTNNLQDMKHLLQLKE---E 459
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT- 533
+ E +R + E KE+L + + + + L +A ++K + +E++
Sbjct: 460 EEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSV 519
Query: 534 -----KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTI 588
KL + K++E N S+E+D + I + +E+ L+ + + + +
Sbjct: 520 MRDEDKLLRIKINELEKKKNQ---CSQELDMKQRTIQQLKEQ-LNNQKVEEAIQQYERAC 575
Query: 589 NGLKEENNSLKSLNDVITREKETQASE---LERSCQVIKQNGFELDKMK 634
L + ++ + + +++TQ + LE + +++ EL+K K
Sbjct: 576 KDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWK 624
Score = 43.2 bits (97), Expect = 0.005
Identities = 71/401 (17%), Positives = 163/401 (40%), Gaps = 15/401 (3%)
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
L KQI + E K L+ + + ++ +YD A+ +L +++ NQ +K +
Sbjct: 119 LNKQIVHSQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELH-VQKSKNQEQEEKIMKLSN 177
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI 822
E + T + + RDL + D+ P +
Sbjct: 178 EIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQL 237
Query: 823 SVI-SDSEVS-QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
++ +D VS Q+KE + + + + +EC+ + ++ Q L+++
Sbjct: 238 DLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIE 297
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW-ANLHSVVVDR-MSYDAEVEKNKR 938
L+ +V K++ + ER+ K D + E L + ++ ++ D +++
Sbjct: 298 KLQAEVKGYKDE--NNRLKEREHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVE 355
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELEELKQRYKE 997
+ + EL K + +++ +E K ++ AK +++ + ++ + +L++ KE
Sbjct: 356 GKRALSELTQGVTCYKAKIKELETILET-QKVERSHSAKLEQDILEKESIILKLERNLKE 414
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK--VALEKQIESLSNTPVSNST 1055
E + + K + K LK + ++ + L + K + L+++ E +
Sbjct: 415 FQEHLQDSVKNTK--DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK 472
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
++ SA QN + D+ ++ + + KL T KK+ K
Sbjct: 473 EELSASSARTQNLK-ADLQRKEEDYADLKEKL-TDAKKQIK 511
Score = 42.7 bits (96), Expect = 0.007
Identities = 56/289 (19%), Positives = 130/289 (44%), Gaps = 15/289 (5%)
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
+N K + + V S E+S +++ L+ +E+ ++ Y E QE++
Sbjct: 110 KNEKEEKAELNKQIVHSQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQE 169
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLHSV----VV 924
E+ +L E + + ++N QI+ ++ V+ ++ D NL +
Sbjct: 170 EKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEE 229
Query: 925 DRM-SYDAEVEKNKRLM-KTIEELRYKKQDLKNTV-TKMQKAMEKYTKKDKEFEAKRKEL 981
D + + ++ N L+ K ++E R ++ + +N+ + ++ E+ + K K ++
Sbjct: 230 DNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQI 289
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E+ + ++E+L+ K +E E + ++ + KE I ++ ++L + V L+
Sbjct: 290 EELEQQIEKLQAEVKGYKDENNRLKEREHKNQDDLLKEKETLIQ-QLKEELQEKNVTLDV 348
Query: 1042 QIESL--SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM-NAKL 1087
QI+ + +S T V A ++ + + E QK+++ +AKL
Sbjct: 349 QIQHVVEGKRALSELTQGVTCYKAKIKE---LETILETQKVERSHSAKL 394
>AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical
rhabdomyosarcoma antigen MU-RMS-40.3 protein.
Length = 941
Score = 80.2 bits (189), Expect = 4e-14
Identities = 174/918 (18%), Positives = 367/918 (39%), Gaps = 68/918 (7%)
Query: 131 DSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL-------TQKCI 183
D L+ + K+N L + L + + + + K DL++N L + +
Sbjct: 10 DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 69
Query: 184 DLEKLVNESENKIGPKNICAQCKLKENL--IQSLHIGYDNTLSKLNRSISDSN---TSTR 238
DLE + + ++ K+ C+L+ + Q+L + + + +L I + + R
Sbjct: 70 DLENDKQQLDERLKKKDF-EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER 128
Query: 239 YNKICTLQSELDAGR--EDCKELCEDFTSI-KNHLELHEPNMT--MDLDEKLGENN-EFE 292
+ T + D R E+ E E+ + +EL++ + L L E + E
Sbjct: 129 ATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHE 188
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL-LAVLDAEFGTTSLDVFEIL 351
+ + ++ L EQ+ N + K K +++ K L + D S+ +
Sbjct: 189 AMVATLRKKHADSVAELGEQIDNLQRVKQK--LEKEKSEFKLEIDDLSSSMESVSKSKAN 246
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
++ I + L E K ++Q L+E T++ + + L+ QL EKE+ + L
Sbjct: 247 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 306
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD-LDQDLPAHKKITILFD 470
K+ + + + + ++EN+ K L L+ S+ D+ R+ +++ ++
Sbjct: 307 KQAFTQQTEELKRQL-EEENKAKNALA-HALQSSRHDCDLLREQYEEEQEGKAELQRALS 364
Query: 471 ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD--------TLEEAH 522
++ RT YE + + E AK + T +
Sbjct: 365 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 424
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSE-----EIDALKIAIAKNEEKMLS--LS 575
EV+ L ++ + + N K+L+E E ++ + E + LS L
Sbjct: 425 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 484
Query: 576 EKDNKLTELVSTINGLKEENNSLK----SLNDVITREKETQASELERSCQVIKQNGFELD 631
+ N E + + +K EN +L+ L + I +T ELE+S + I+ ++
Sbjct: 485 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT-IHELEKSRKQIELEKADIQ 543
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK-EQCEEKTRDCSRLEINIKTHE 690
+ + KS +++ +A K E+ E+ R+ R +
Sbjct: 544 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQR-TVETMQSA 602
Query: 691 KTAEIQNR-MIMRLQKQIQEDDKLFIEKETKLNELTNK-YEALK--RDYDAAVKDLESSR 746
AE+++R +RL+K+++ D E E +L+ + E LK R +KD +
Sbjct: 603 LDAEVRSRNEAIRLKKKMEGD---LNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHL 659
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
+ + L Q+DL E ++A +E Q A V +E
Sbjct: 660 D--DALRGQEDLKE-QLAIVERRANLLQ-AEVEELRATLEQTERARKLAEQELLDSNERV 715
Query: 807 DL--GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
L +N L + K+ ++++ QL+ + ++ + +E+ K+ + AE
Sbjct: 716 QLLHTQNTSLIHTKKK-----LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEE 770
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
L++ + A L++ K +LEQ V +L+ ++ + + + + + L +
Sbjct: 771 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ-KLETRIRELEFELE 829
Query: 925 DRMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL-E 982
+ E K ++ + ++EL Y+ ++ + V ++Q ++K K K ++ + +E E
Sbjct: 830 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE 889
Query: 983 DCKAELEELKQRYKELDE 1000
A L + ++ EL+E
Sbjct: 890 QANAHLTKFRKAQHELEE 907
Score = 77.8 bits (183), Expect = 2e-13
Identities = 175/968 (18%), Positives = 383/968 (39%), Gaps = 72/968 (7%)
Query: 140 INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE--KLVNESENKIG 197
+++LQ E D +++L N T+S L ++V+DL+ + E + +DLE K E + K+
Sbjct: 9 LDDLQAEEDKVNSL---NKTKS-KLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLA 64
Query: 198 PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT-STRYNKICTLQSELDAGREDC 256
++I K+ L + L D +L + D T ++ K EL A E+
Sbjct: 65 QESILDLENDKQQLDERLK-KKDFEYCQLQSKVEDEQTLGLQFQKKI---KELQARIEEL 120
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
+E E + + E + +L+E L E E E+ + + +L +
Sbjct: 121 EEEIEAERATRAKTEKQRSDYARELEE-LSERLEEAGGVTSTQIELNKKREAEFLKLRRD 179
Query: 317 ESKKSKDHIDRYKDSLLAVLD--AEFGTT--SLDVFEILMDNIINKYQIDLDEILEKYTK 372
+ + H D AE G +L + ++ +++++++D++
Sbjct: 180 LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 239
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
V +++ ++L+ + E + + + L QK R+ + ++ + +KE+
Sbjct: 240 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 299
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE-KLR 491
+ + L++ ++ ++ R L+++ A + + +L R YE E+E K
Sbjct: 300 VSQ-LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 358
Query: 492 LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK 551
L+ +KA EE EE K ++ ++ + +
Sbjct: 359 LQRALSKANSEVAQWRTKYETDAIQRTEEL--------EEAKKKLAQRLQDSEEQVEAVN 410
Query: 552 ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKET 611
++ K + E ++ E+ N L + K++ N K L + T+ +E+
Sbjct: 411 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD-----KKQRNFDKVLAEWKTKCEES 465
Query: 612 QASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQ 671
QA ELE S + + EL K+K E L EQ +
Sbjct: 466 QA-ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 524
Query: 672 CEEKTRDCSRLEIN-------IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
E + ++E+ ++ E E + I+R+Q ++ + E + K+ E
Sbjct: 525 IHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS---EIDRKIAEK 581
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
+ E LKR+Y V+ ++S+ +A ++ ++ + + + ++E D+ + +
Sbjct: 582 DEEIEQLKRNYQRTVETMQSALDA--EVRSRNEAIRLK-KKMEGDLNEIE---IQLSHAN 635
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
D L + + + K ++++ + + L+ + + L
Sbjct: 636 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV-ERRANLLQAEVEELRATL 694
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
+ + K + E E +Q Q L K LE + L+ ++ R A+
Sbjct: 695 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAE 754
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKTIEELRYKKQD-----LKNTVT 958
+ A D A + + A +E+ K+ L +T+++L+++ + LK
Sbjct: 755 --EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 812
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
++QK + + + E E ++K+ + L + ++R KEL Q EE K
Sbjct: 813 QIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKEL----------TYQSEEDRKN 862
Query: 1019 LKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ + ++VDKL + + ++Q E ++ T + + + ++ D+ +
Sbjct: 863 VLRLQ---DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAE--S 917
Query: 1079 KLKKMNAK 1086
++ K+ AK
Sbjct: 918 QVNKLRAK 925
Score = 68.5 bits (160), Expect = 1e-10
Identities = 126/742 (16%), Positives = 303/742 (40%), Gaps = 35/742 (4%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
K ++D E + +L+++G +T S ++ + K + + L+ + L + +
Sbjct: 136 KQRSDYARELEELSERLEEAGGVT-STQIELNKKREAEFLKLRRD-LEEATLQHEAMVAT 193
Query: 91 LEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDT 149
L K+ + + E + D L + LE E EI +L+ S+++ SK L++ T
Sbjct: 194 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 253
Query: 150 LSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKE 209
L + + E +++ + + + +L L + +L + + E E+ + + Q ++
Sbjct: 254 LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQ 313
Query: 210 NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL-QSELDAGREDCKELCEDFTSIKN 268
+ +N K +++ + S+R++ C L + + + +E EL + +
Sbjct: 314 TEELKRQLEEEN---KAKNALAHALQSSRHD--CDLLREQYEEEQEGKAELQRALSKANS 368
Query: 269 HLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRY 328
+ D ++ E E + K + + + + + +++ + + E K +
Sbjct: 369 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ-GEV 427
Query: 329 KDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
+D ++ V A +LD + D ++ +++ +E Q +L E +S++
Sbjct: 428 EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEES-------QAELEASLKESRSLS 480
Query: 389 EKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEI-LTKECLKLSKL 447
+L L + E + ++ + + + + + +T I + + E+ +++ ++L K
Sbjct: 481 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 540
Query: 448 KIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXX 507
I + + + H++ IL Q EL++ EI++ K+ + + +
Sbjct: 541 DIQLALEEAEAALEHEEAKILR----IQLELTQVKSEIDR-KIAEKDEEIEQLKRNYQRT 595
Query: 508 XXXXXXXFDTLEEAHNEVKSLHEELT-KLYKSKVDENNAN---LNLIKILSEEIDALKIA 563
D + NE L +++ L + ++ ++AN +K L LK
Sbjct: 596 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 655
Query: 564 IAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERS---C 620
++ + + +L + N L+ E L++ + R ++ EL S
Sbjct: 656 QLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 715
Query: 621 QVIKQNGFEL----DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT 676
Q++ L K++ D++ ++AK + + E+ +++
Sbjct: 716 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 775
Query: 677 RDCSRLEINIKTHEKTA-EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ LE K E+T ++Q+R+ Q ++ K + ET++ EL + E ++
Sbjct: 776 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKN 835
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
+VK L V +LT Q +
Sbjct: 836 TESVKGLRKYERRVKELTYQSE 857
Score = 67.3 bits (157), Expect = 3e-10
Identities = 126/714 (17%), Positives = 288/714 (40%), Gaps = 44/714 (6%)
Query: 80 ELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKK 139
EL ++ E+ G I + R+ +++ ++E T E T K +
Sbjct: 144 ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR-DLEEATLQHEAMVAT-LRKKHADS 201
Query: 140 INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP- 198
+ EL E+ D L + + E E+DDL + E +++ +LEK+ E+++
Sbjct: 202 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 261
Query: 199 --KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDC 256
KN Q L E Q + +L+R + + + +++ + E+
Sbjct: 262 RGKNEEIQRSLSELTTQKSRL--QTEAGELSRQLEEKESIV--SQLSRSKQAFTQQTEEL 317
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLD---EKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
K E+ KN L + D D E+ E E + + + +S+ + +
Sbjct: 318 KRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY 377
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV 373
+ +++++ + K + D+E +++ ++ + Q ++++++
Sbjct: 378 ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV----- 432
Query: 374 QGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENEL 433
D+ S ++++K + + L E + C + + E + S +++ ++ K +N
Sbjct: 433 --DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 490
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
+E L +L +K + ++L+Q++ + I + E SR E+EK ++L
Sbjct: 491 EEALD----QLETVKRE-NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 545
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKL---YKSKVDENNANLNL 549
A+A ++ E ++ EE+ +L Y+ V+ + L+
Sbjct: 546 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 605
Query: 550 -IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE-NNSLKSLNDVITR 607
++ +E I K E + LS + + E + + ++ + ++ L+D +
Sbjct: 606 EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG 665
Query: 608 EKE--TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
+++ Q + +ER +++ E+++++A + + + L QN
Sbjct: 666 QEDLKEQLAIVERRANLLQA---EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 722
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELT 725
+L ++ D +L+ ++ + A R K+ D + E+ K + +
Sbjct: 723 TSLIHTKKKLETDLMQLQSEVEDASRDA----RNAEEKAKKAITDAAMMAEELKKEQDTS 778
Query: 726 NKYEALKRDYDAAVKDLESSREAVNQLT-----TQKDLVEGRIAELESDIRTEQ 774
E +K++ + VKDL+ + QL Q +E RI ELE ++ EQ
Sbjct: 779 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQ 832
Score = 66.5 bits (155), Expect = 5e-10
Identities = 74/355 (20%), Positives = 143/355 (40%), Gaps = 17/355 (4%)
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
L+ + A+ DL++ + VN L K +E ++ +LES + E+ V
Sbjct: 1 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGD 60
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
++ + L E K D + S+V + L Q+++ +L+ R
Sbjct: 61 LKLAQESILDLENDKQQLDERLKKKDFEYCQL----QSKVEDEQTLGLQFQKKIKELQAR 116
Query: 851 YKELDDECE----TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
+EL++E E T A+ ++R + L++ LE+ QI + +R+A+F
Sbjct: 117 IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK--KREAEFL 174
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
+ + +E ++V A+ E+ L + ++L +K + K + +
Sbjct: 175 KLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 234
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
+ME +K E + LED +E + + E T L+ + R E
Sbjct: 235 SSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLE 294
Query: 1022 AKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
K + IV +LS K A +Q E L + A A+ ++ D+++E
Sbjct: 295 EKES--IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 347
Score = 64.9 bits (151), Expect = 2e-09
Identities = 160/794 (20%), Positives = 311/794 (39%), Gaps = 98/794 (12%)
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQG 375
N K+K +++ + L + L+ E + ++ K + DL E ++
Sbjct: 20 NSLNKTKSKLEQQVEDLESSLEQE------KKLRVDLERNKRKLEGDLKLAQESILDLEN 73
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE 435
D + LK + + L S+ +E E L+ QK +I E+ + I+ +++E E E
Sbjct: 74 DKQQLDERLKKKDFEYCQLQSK-VEDEQTLG-LQFQK-KIKELQAR--IEELEEEIEA-E 127
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG 495
T+ K K + D R+L++ +++ TQ EL++ + E E L+L
Sbjct: 128 RATRA--KTEKQRSDYARELEE---LSERLEEAGGVTSTQIELNK---KREAEFLKLRRD 179
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK------VDENNANL-- 547
+A D++ E ++ +L KL K K +D+ ++++
Sbjct: 180 LEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 239
Query: 548 ------NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL 601
NL KI D L A KNEE SLSE + + L + L +
Sbjct: 240 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ------- 292
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
EKE+ S+L RS Q Q EL + + ++AK+
Sbjct: 293 ----LEEKESIVSQLSRSKQAFTQQTEELKRQLEE------------------ENKAKNA 330
Query: 662 LEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
L L + DC L + +E+ E + + L K E + + ET
Sbjct: 331 LAHAL------QSSRHDCDLLR---EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 381
Query: 722 NELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXX 781
+ T + E K+ ++D E EAVN + + R+ D+ +
Sbjct: 382 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 441
Query: 782 XXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQ 841
T +E++ +L+ S K S S+ +E+ +LK
Sbjct: 442 AALDKKQRNFDKVLAEWKTKCEESQ-----AELEASLKESRSL--STELFKLKNAYEEAL 494
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVER 901
+L+ +K K L+ E E + E + L+K + +E + +++ Q+ ++
Sbjct: 495 DQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADI--QLALEE---- 548
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
A+ A+ +E A + + ++ +E++ +++ + EE+ K++ + TV MQ
Sbjct: 549 ----AEAALEHEE--AKILRIQLELTQVKSEID--RKIAEKDEEIEQLKRNYQRTVETMQ 600
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK- 1020
A++ + E +K++E +L E++ + + + ++L+ + Q K +
Sbjct: 601 SALDAEVRSRNEAIRLKKKME---GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 657
Query: 1021 EAKIALEIVDKLSNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
AL + L Q +E++ L + +T+ + + Q++ D + Q
Sbjct: 658 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 717
Query: 1080 LKKMNAKLITICKK 1093
L N LI KK
Sbjct: 718 LHTQNTSLIHTKKK 731
Score = 41.1 bits (92), Expect = 0.021
Identities = 122/715 (17%), Positives = 283/715 (39%), Gaps = 46/715 (6%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM 117
K+C++L++ +E K E++ L ++ QKS L+ + L + + ++ ++SQ+ +
Sbjct: 249 KICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 308
Query: 118 ENLTKDKEIK-NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD-DLKKNN 175
+ +E+K L + K K+ + LQ +L+ E E E+ L K N
Sbjct: 309 AFTQQTEELKRQLEEENKAKNALAHALQSSRHD-CDLLREQYEEEQEGKAELQRALSKAN 367
Query: 176 ECLTQ--KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLH---IGYDNTLSKLNRSI 230
+ Q + + + E + K + + + E +++++ + T +L +
Sbjct: 368 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV 427
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
D + +L + LD + + ++ ++ K E +L+ L E+
Sbjct: 428 EDLMVDV--ERANSLAAALDKKQRNFDKVLAEW---KTKCE----ESQAELEASLKESRS 478
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSK--DHIDRYKDSLLAVLDAEFGTTSLDVF 348
T+ K+ + + L+ L N++ + + D ++ ++ + + E +++
Sbjct: 479 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELE 538
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL--IEKENACN 406
+ + + + + L+ K ++Q +L + SE ++ K+A + ++ +++
Sbjct: 539 KADIQLALEEAEAALEHEEAKILRIQLELTQVKSE---IDRKIAEKDEEIEQLKRNYQRT 595
Query: 407 ILRIQKERIHEISSA-VTIDIVKK-ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
+ +Q E+ S I + KK E +L EI + ++ + + L + + K
Sbjct: 596 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEI-EIQLSHANRQAAETLKHL-RSVQGQLK 653
Query: 465 ITILF--DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAH 522
T L DAL Q +L + I + + L + + L +++
Sbjct: 654 DTQLHLDDALRGQEDL-KEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSN 712
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
V+ LH + T L +K +L+++ SE DA + A E+ ++++
Sbjct: 713 ERVQLLHTQNTSLIHTK---KKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAE 769
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
EL + K+L + ++ + + E E+ +K ++ K++ I
Sbjct: 770 ELKKEQDTSAHLERMKKNLEQTV-KDLQHRLDEAEQ--LALKGGKKQIQKLETRI---RE 823
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKE---QCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ K L + +KE Q EE ++ RL+ + + + R
Sbjct: 824 LEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQ 883
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLESSREAVNQ 751
+Q F + + +L E + + + + A +D SSR V++
Sbjct: 884 AEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 938
>AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,
cardiac muscle, beta protein.
Length = 1983
Score = 80.2 bits (189), Expect = 4e-14
Identities = 221/1076 (20%), Positives = 439/1076 (40%), Gaps = 110/1076 (10%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L +S ++ K+++LS L D +E +
Sbjct: 931 QEKNDLALQLQAEQDNLADAE------ERCHLLIKSKVQLEGKVKELSERLEDEEEVNAD 984
Query: 91 LEGKYQNLILE-TQTR---DLLMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L + + L E T+ + D L + E E + ++KNLT+ + TK
Sbjct: 985 LAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1044
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK + +LQ E D +S L + L ++V+DL+ + E + +D E+
Sbjct: 1045 KKALQEAHQQALGDLQAEEDRVSALTKAKL----RLEQQVEDLECSLEQEKKLRMDTERA 1100
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICT 244
E + K+ +++ + K+ L + L D+ LS+L+ + D + KI
Sbjct: 1101 KRKLEGDLKLTQESVADAAQDKQQLEEKLK-KKDSELSQLSLRVEDEQLLGAQMQKKI-- 1157
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV-------- 296
EL A E+ +E E + + +E +L+E L E E A
Sbjct: 1158 --KELQARAEELEEELEAERAARARVEKQRAEAARELEE-LSERLEEAGGASAGQREGCR 1214
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K +E+ R L E + +E+ + + R + A L + SL ++
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAA--LRRKQAEGAAELGEQ--VDSLQRVRQKLEKEK 1270
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
++ ++++D++ + ++ ++L+ ++ E + Q+ R+
Sbjct: 1271 SELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ 1330
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
S ++ + +KE + ++ + L L+ ++ R L+++ A + AL
Sbjct: 1331 TESGELSRLLEEKECLISQLSRGKALAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDC 1389
Query: 477 ELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL 535
+L R +E E E + L+ +KA EE K L L +
Sbjct: 1390 DLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1449
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
+ V+ NA K S E L++ ++E+ L L + T + ++ K++
Sbjct: 1450 -EEGVEAANA-----KCSSLEKAKLRLQ-TESEDVTLEL----ERATSAAAALD--KKQR 1496
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
+ ++L + +E+E Q ELE + + + G EL +++
Sbjct: 1497 HLERALEERRRQEEEMQ-RELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQ 1555
Query: 656 DEAKSLLEQ-NLALKEQCE-EKTR-----DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ 708
+E L +Q +L+ K E EKT+ + S ++ ++ E E++ +R+Q ++
Sbjct: 1556 EEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELS 1615
Query: 709 EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIA 764
+ + E + KL E + L+R++ AV+ L++S +A N+ K +EG +
Sbjct: 1616 Q---VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1672
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV 824
+LE + AT +E R E + + +R S+
Sbjct: 1673 DLELQL---GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1729
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKEL-DDECETCAEYLQERDEQCARLKKEKLSLE 883
++ +E+ +L+ L + ER + L + E E L Q L +K LE
Sbjct: 1730 LA-AELEELRAAL--------EQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1780
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKT 942
++ L ++ R+A+ + A D A + + A +E+ K+ L +T
Sbjct: 1781 ADLAQLSGEVEEAAQERREAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQT 1838
Query: 943 IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEE 1001
+ EL+ + ++ + Q A+ K+ ++ EAK +ELE + AE ++ + K + +
Sbjct: 1839 VRELQARLEEAE------QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKH 1892
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
E Q EE K L + ++VDKL ++ + ++Q E +N Y
Sbjct: 1893 ERRVKELAYQAEEDRKNLARMQ---DLVDKLQSKVKSYKRQFEEAEQQANTNLAKY 1945
Score = 64.1 bits (149), Expect = 3e-09
Identities = 84/423 (19%), Positives = 171/423 (40%), Gaps = 28/423 (6%)
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
L+++C E +D L++ + EK + + L +++ D+ + LT +
Sbjct: 992 LEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDE-------SVARLTKE 1044
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
+AL+ + A+ DL++ + V+ LT K +E ++ +LE + E+ +
Sbjct: 1045 KKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKL 1104
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV-ISDSEV--SQLKERLLSCQQEL 844
+ + L E K DS +S+ + D ++ +Q+++++ Q
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1164
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
++L+E EL+ E A ++R E L E+LS + + + + +R+A+
Sbjct: 1165 EELEE---ELEAERAARARVEKQRAEAAREL--EELSERLEEAGGASAGQREGCRKREAE 1219
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAE-----VEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ +E + V AE E+ L + ++L +K +L+ V
Sbjct: 1220 LGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD 1279
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE---ECETCAEYLKQREEQC 1016
+ +E T+ E + ED +L E K + +EL + T L+ +
Sbjct: 1280 LAANVETLTRAKASAEKLCRTYED---QLSEAKIKVEELQRQLADASTQRGRLQTESGEL 1336
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
RL E K L + +LS K + +E L S A A+ + D+++E
Sbjct: 1337 SRLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1394
Query: 1077 NQK 1079
+
Sbjct: 1395 QHE 1397
Score = 60.1 bits (139), Expect = 4e-08
Identities = 184/1002 (18%), Positives = 380/1002 (37%), Gaps = 55/1002 (5%)
Query: 73 KLEKLSGELFDIKEQKSALEGKYQNL----ILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
+L L EL ++ +A E K Q L + TQ ++ L Q+++ E +NL +E +
Sbjct: 897 ELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQA-EQDNLADAEERCH 955
Query: 129 LTDSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L K + + K+ EL E + + + L E +LKK+ + L EK
Sbjct: 956 LLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEK 1015
Query: 188 LVNESENKIGPKNICAQ-CKLKENLI------QSLHIGYDNTLSKLNRSISDSNTSTRYN 240
+ENK+ KN+ + L E++ ++L + L L + T+
Sbjct: 1016 EKQATENKV--KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1073
Query: 241 KICTLQSE-LDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
Q E L+ E K+L D K LE + + + + E K K
Sbjct: 1074 LRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKD 1133
Query: 300 SEIKR-NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
SE+ + +L EQL+ + +K + + L L+AE + ++ +
Sbjct: 1134 SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARA------RVEKQRAE 1187
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+L+E+ E+ + G + + ++ A L E E A +
Sbjct: 1188 AARELEELSERLEEAGG---ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRK 1244
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL 478
+ ++ ++ + L+ + K + S+L++++ DL ++ + + L YE
Sbjct: 1245 QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVD-DLAANVETLTRAKASAEKLCRTYED 1303
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV---KSLH----EE 531
++ +I+ E+L+ + A + E +++ K+L EE
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + + + +A + ++ L + D L+ + E L +K V+
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS- 1422
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
K E ++++ + + K+ A L+ + + ++ + ++ L
Sbjct: 1423 KYEADAIQRTEE-LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
A +L ++ L+ EE+ R ++ ++ ++ + + RL+ +E
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ + + L + L + K ++ + L +K ++ + E E +
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
E+T T+ +++ + + S+ D+E
Sbjct: 1602 LEETKTL------RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1655
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
E L ++ DL + +L E A+LK+E+ +++ E
Sbjct: 1656 ARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1715
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE-VEKNKRLMKTIEE---LR 947
Q +ER+A +A +E A L R + E +E +RL + L
Sbjct: 1716 LHEQAQALERRASL--LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1773
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELEELKQRYKELDEECETCA 1006
+K+ L+ + ++ +E+ ++ +E E K +K + D EELK+ ++ E
Sbjct: 1774 NQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMK 1832
Query: 1007 EYLKQ--REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ L+Q RE Q RL+EA+ A K QK LE ++ L
Sbjct: 1833 KTLEQTVRELQA-RLEEAEQAALRGGKKQVQK--LEAKVREL 1871
Score = 46.0 bits (104), Expect = 8e-04
Identities = 146/790 (18%), Positives = 300/790 (37%), Gaps = 71/790 (8%)
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
D+D++ K + + +++K++ E++A+L+ + L +K+ + E
Sbjct: 1002 DIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR-------LTKEKKALQEAHQQ 1054
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-----KITILFDALITQY 476
D+ +E+ + LTK L+L + D+ L+Q+ K + D +TQ
Sbjct: 1055 ALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1113
Query: 477 ELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT- 533
++ D + +EKL+ + + ++E + L EEL
Sbjct: 1114 SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 534 -KLYKSKVDENNANL-NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
+ +++V++ A ++ LSE ++ A A E + +L + L
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEA-AL 1232
Query: 592 KEENN--SLKSLNDVITREKETQASELERSCQVIKQNGFEL----DKMKADILMXXXXXX 645
+ E +L+ E Q L+R Q +++ EL D + A++
Sbjct: 1233 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA 1292
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
D+ + L+ Q + + RL+ + E + +I +L +
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 706 ------QIQEDDKLFIEKETKLNE-LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
Q E+ + +E+E+K L + +AL+ D D + E EA +L
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1412
Query: 759 VEGRIAE----LESDI--RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+A+ E+D RTE+ E L
Sbjct: 1413 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1472
Query: 813 KLDDSP---KRSISVISDSEVSQ------LKERLLS---CQQELDDLKERYKELDDECET 860
+ +D +R+ S + + Q L+ER Q+EL+ + + L E
Sbjct: 1473 ESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVA 909
+E E LK+E +L++++S+L +Q+ +T++ +E + A
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592
Query: 910 VNTDEDWANLHSVVVDRMSYD---AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
+ E L R+ + + E +++L + EE +++ + V +Q +++
Sbjct: 1593 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA 1652
Query: 967 YTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDE-ECETCAEYLKQREEQCKRLKEAKI 1024
T+ E +K++E +LE +L ++ E + T + +EEQ R +E ++
Sbjct: 1653 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL 1712
Query: 1025 ALEIVDKLSNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
A E L Q ALE++ L + + + S + Q++ + + L
Sbjct: 1713 AAE----LHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768
Query: 1084 NAKLITICKK 1093
N L+ KK
Sbjct: 1769 NTGLLNQKKK 1778
Score = 45.6 bits (103), Expect = 0.001
Identities = 181/1024 (17%), Positives = 383/1024 (37%), Gaps = 64/1024 (6%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLS----NLIMENVTESDNLNKEVDDLKKNNECLTQ 180
E++ L +L K EL+E + +++ +L ++ E DNL D ++ L +
Sbjct: 904 ELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA----DAEERCHLLIK 959
Query: 181 KCIDLEKLVNE-SENKIGPKNICAQCKLKENLIQS--LHIGYDNTLSKLNRSISDSNTST 237
+ LE V E SE + + A + ++ + D KL + ++
Sbjct: 960 SKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQA 1019
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
NK+ L E+ A E L ++ +++ + ++ + ++++ + + + +
Sbjct: 1020 TENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAE-EDRVSALTKAKLRLEQ 1078
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+ +++ +L + ++ E K K D K + +V DA L+ D+ ++
Sbjct: 1079 QVEDLECSLEQEKKLRMDTERAKRKLEGD-LKLTQESVADAAQDKQQLEEKLKKKDSELS 1137
Query: 358 KYQIDLDE-------ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
+ + +++ + +K ++Q E EL++ A + Q E L
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 411 QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
+ E S+ K+E EL L +E L+ + L+ + + A +
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGR-LRRE-LEEAALRHEATVAALRRKQAEGAAEL--G 1253
Query: 471 ALITQYELSRTDYEIEKEKLRLET----GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
+ + R E EK +LR+E + + D L EA +V+
Sbjct: 1254 EQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVE 1313
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML-SLSEKDNKLTELV 585
L +L + + L ++L EE + L +++ + SL E +L E
Sbjct: 1314 ELQRQLADASTQRGRLQTESGELSRLL-EEKECLISQLSRGKALAAQSLEELRRQLEEES 1372
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+ L +L+ D++ RE+ + +E + Q + L K A++
Sbjct: 1373 KAKSALAHAVQALRHDCDLL-REQHEEEAEAQAELQRL------LSKANAEVAQWRSKYE 1425
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLE-----INIKTHEKTAEIQNRM 699
+EAK L L E+ E CS LE + ++ + T E++
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485
Query: 700 --IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
L K+ + ++ E+ + E+ + EA +R+ +L R + +
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP-KLDD 816
++ L+ +I ++ T V + + E +L++
Sbjct: 1546 TLKRENKNLQEEI-SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEE 1604
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
+ I + +++ +L +E +L+ ++ + + + + RLK
Sbjct: 1605 TKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLK 1664
Query: 877 KEKLS----LEQQVSNLKEQIRTQQPVER--QAKFADVAVNTDEDW---ANLH--SVVVD 925
K+ LE Q+ + Q Q R QA+ + DE+ A LH + ++
Sbjct: 1665 KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALE 1724
Query: 926 RMS--YDAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R + AE+E+ + ++ E R +Q+L ++ + T + + +L
Sbjct: 1725 RRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV-ALEK 1041
E+EE Q +E +E+ + E+ K+ ++ LE + K Q V L+
Sbjct: 1785 QLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1844
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANR 1101
++E + V A V +++ + QK K + ++R K A +
Sbjct: 1845 RLEEAEQAALRGGKKQVQKLEAKV--RELEAELDAEQKKHAEALKGVRKHERRVKELAYQ 1902
Query: 1102 ENED 1105
ED
Sbjct: 1903 AEED 1906
Score = 41.5 bits (93), Expect = 0.016
Identities = 50/216 (23%), Positives = 102/216 (47%), Gaps = 19/216 (8%)
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
A+ ++E +L ++ L+ + + ++ + V++ +++ L DAE
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 951
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
E+ L+K+ K L+ V ++ + +E + + + A+R++LED E ELK
Sbjct: 952 -ERCHLLIKS-------KVQLEGKVKELSERLEDEEEVNADLAARRRKLED---ECTELK 1000
Query: 993 QRYKELDEECETCAEYLKQR---EEQCKRLKEAKIAL-EIVDKLSNQKVAL-EKQIESLS 1047
K++D+ T A+ K++ E + K L E AL E V +L+ +K AL E ++L
Sbjct: 1001 ---KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALG 1057
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
+ + T + + QQ+ D+ ++ KK+
Sbjct: 1058 DLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKL 1093
>AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,
cardiac muscle, beta protein.
Length = 1983
Score = 80.2 bits (189), Expect = 4e-14
Identities = 221/1076 (20%), Positives = 439/1076 (40%), Gaps = 110/1076 (10%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L +S ++ K+++LS L D +E +
Sbjct: 931 QEKNDLALQLQAEQDNLADAE------ERCHLLIKSKVQLEGKVKELSERLEDEEEVNAD 984
Query: 91 LEGKYQNLILE-TQTR---DLLMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L + + L E T+ + D L + E E + ++KNLT+ + TK
Sbjct: 985 LAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1044
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK + +LQ E D +S L + L ++V+DL+ + E + +D E+
Sbjct: 1045 KKALQEAHQQALGDLQAEEDRVSALTKAKL----RLEQQVEDLECSLEQEKKLRMDTERA 1100
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICT 244
E + K+ +++ + K+ L + L D+ LS+L+ + D + KI
Sbjct: 1101 KRKLEGDLKLTQESVADAAQDKQQLEEKLK-KKDSELSQLSLRVEDEQLLGAQMQKKI-- 1157
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV-------- 296
EL A E+ +E E + + +E +L+E L E E A
Sbjct: 1158 --KELQARAEELEEELEAERAARARVEKQRAEAARELEE-LSERLEEAGGASAGQREGCR 1214
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K +E+ R L E + +E+ + + R + A L + SL ++
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAA--LRRKQAEGAAELGEQ--VDSLQRVRQKLEKEK 1270
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
++ ++++D++ + ++ ++L+ ++ E + Q+ R+
Sbjct: 1271 SELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ 1330
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
S ++ + +KE + ++ + L L+ ++ R L+++ A + AL
Sbjct: 1331 TESGELSRLLEEKECLISQLSRGKALAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDC 1389
Query: 477 ELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL 535
+L R +E E E + L+ +KA EE K L L +
Sbjct: 1390 DLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1449
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
+ V+ NA K S E L++ ++E+ L L + T + ++ K++
Sbjct: 1450 -EEGVEAANA-----KCSSLEKAKLRLQ-TESEDVTLEL----ERATSAAAALD--KKQR 1496
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
+ ++L + +E+E Q ELE + + + G EL +++
Sbjct: 1497 HLERALEERRRQEEEMQ-RELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQ 1555
Query: 656 DEAKSLLEQ-NLALKEQCE-EKTR-----DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ 708
+E L +Q +L+ K E EKT+ + S ++ ++ E E++ +R+Q ++
Sbjct: 1556 EEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELS 1615
Query: 709 EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIA 764
+ + E + KL E + L+R++ AV+ L++S +A N+ K +EG +
Sbjct: 1616 Q---VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1672
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV 824
+LE + AT +E R E + + +R S+
Sbjct: 1673 DLELQL---GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1729
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKEL-DDECETCAEYLQERDEQCARLKKEKLSLE 883
++ +E+ +L+ L + ER + L + E E L Q L +K LE
Sbjct: 1730 LA-AELEELRAAL--------EQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1780
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKT 942
++ L ++ R+A+ + A D A + + A +E+ K+ L +T
Sbjct: 1781 ADLAQLSGEVEEAAQERREAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQT 1838
Query: 943 IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEE 1001
+ EL+ + ++ + Q A+ K+ ++ EAK +ELE + AE ++ + K + +
Sbjct: 1839 VRELQARLEEAE------QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKH 1892
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
E Q EE K L + ++VDKL ++ + ++Q E +N Y
Sbjct: 1893 ERRVKELAYQAEEDRKNLARMQ---DLVDKLQSKVKSYKRQFEEAEQQANTNLAKY 1945
Score = 64.1 bits (149), Expect = 3e-09
Identities = 84/423 (19%), Positives = 171/423 (40%), Gaps = 28/423 (6%)
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
L+++C E +D L++ + EK + + L +++ D+ + LT +
Sbjct: 992 LEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDE-------SVARLTKE 1044
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
+AL+ + A+ DL++ + V+ LT K +E ++ +LE + E+ +
Sbjct: 1045 KKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKL 1104
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV-ISDSEV--SQLKERLLSCQQEL 844
+ + L E K DS +S+ + D ++ +Q+++++ Q
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1164
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
++L+E EL+ E A ++R E L E+LS + + + + +R+A+
Sbjct: 1165 EELEE---ELEAERAARARVEKQRAEAAREL--EELSERLEEAGGASAGQREGCRKREAE 1219
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAE-----VEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ +E + V AE E+ L + ++L +K +L+ V
Sbjct: 1220 LGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD 1279
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE---ECETCAEYLKQREEQC 1016
+ +E T+ E + ED +L E K + +EL + T L+ +
Sbjct: 1280 LAANVETLTRAKASAEKLCRTYED---QLSEAKIKVEELQRQLADASTQRGRLQTESGEL 1336
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
RL E K L + +LS K + +E L S A A+ + D+++E
Sbjct: 1337 SRLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1394
Query: 1077 NQK 1079
+
Sbjct: 1395 QHE 1397
Score = 60.1 bits (139), Expect = 4e-08
Identities = 184/1002 (18%), Positives = 380/1002 (37%), Gaps = 55/1002 (5%)
Query: 73 KLEKLSGELFDIKEQKSALEGKYQNL----ILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
+L L EL ++ +A E K Q L + TQ ++ L Q+++ E +NL +E +
Sbjct: 897 ELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQA-EQDNLADAEERCH 955
Query: 129 LTDSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L K + + K+ EL E + + + L E +LKK+ + L EK
Sbjct: 956 LLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEK 1015
Query: 188 LVNESENKIGPKNICAQ-CKLKENLI------QSLHIGYDNTLSKLNRSISDSNTSTRYN 240
+ENK+ KN+ + L E++ ++L + L L + T+
Sbjct: 1016 EKQATENKV--KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1073
Query: 241 KICTLQSE-LDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
Q E L+ E K+L D K LE + + + + E K K
Sbjct: 1074 LRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKD 1133
Query: 300 SEIKR-NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
SE+ + +L EQL+ + +K + + L L+AE + ++ +
Sbjct: 1134 SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARA------RVEKQRAE 1187
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+L+E+ E+ + G + + ++ A L E E A +
Sbjct: 1188 AARELEELSERLEEAGG---ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRK 1244
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL 478
+ ++ ++ + L+ + K + S+L++++ DL ++ + + L YE
Sbjct: 1245 QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVD-DLAANVETLTRAKASAEKLCRTYED 1303
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV---KSLH----EE 531
++ +I+ E+L+ + A + E +++ K+L EE
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + + + +A + ++ L + D L+ + E L +K V+
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS- 1422
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
K E ++++ + + K+ A L+ + + ++ + ++ L
Sbjct: 1423 KYEADAIQRTEE-LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
A +L ++ L+ EE+ R ++ ++ ++ + + RL+ +E
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ + + L + L + K ++ + L +K ++ + E E +
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1601
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
E+T T+ +++ + + S+ D+E
Sbjct: 1602 LEETKTL------RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1655
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
E L ++ DL + +L E A+LK+E+ +++ E
Sbjct: 1656 ARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1715
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE-VEKNKRLMKTIEE---LR 947
Q +ER+A +A +E A L R + E +E +RL + L
Sbjct: 1716 LHEQAQALERRASL--LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1773
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELEELKQRYKELDEECETCA 1006
+K+ L+ + ++ +E+ ++ +E E K +K + D EELK+ ++ E
Sbjct: 1774 NQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMK 1832
Query: 1007 EYLKQ--REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ L+Q RE Q RL+EA+ A K QK LE ++ L
Sbjct: 1833 KTLEQTVRELQA-RLEEAEQAALRGGKKQVQK--LEAKVREL 1871
Score = 46.0 bits (104), Expect = 8e-04
Identities = 146/790 (18%), Positives = 300/790 (37%), Gaps = 71/790 (8%)
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
D+D++ K + + +++K++ E++A+L+ + L +K+ + E
Sbjct: 1002 DIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR-------LTKEKKALQEAHQQ 1054
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-----KITILFDALITQY 476
D+ +E+ + LTK L+L + D+ L+Q+ K + D +TQ
Sbjct: 1055 ALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1113
Query: 477 ELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT- 533
++ D + +EKL+ + + ++E + L EEL
Sbjct: 1114 SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 534 -KLYKSKVDENNANL-NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
+ +++V++ A ++ LSE ++ A A E + +L + L
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEA-AL 1232
Query: 592 KEENN--SLKSLNDVITREKETQASELERSCQVIKQNGFEL----DKMKADILMXXXXXX 645
+ E +L+ E Q L+R Q +++ EL D + A++
Sbjct: 1233 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA 1292
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
D+ + L+ Q + + RL+ + E + +I +L +
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 706 ------QIQEDDKLFIEKETKLNE-LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
Q E+ + +E+E+K L + +AL+ D D + E EA +L
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1412
Query: 759 VEGRIAE----LESDI--RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+A+ E+D RTE+ E L
Sbjct: 1413 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1472
Query: 813 KLDDSP---KRSISVISDSEVSQ------LKERLLS---CQQELDDLKERYKELDDECET 860
+ +D +R+ S + + Q L+ER Q+EL+ + + L E
Sbjct: 1473 ESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVA 909
+E E LK+E +L++++S+L +Q+ +T++ +E + A
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592
Query: 910 VNTDEDWANLHSVVVDRMSYD---AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
+ E L R+ + + E +++L + EE +++ + V +Q +++
Sbjct: 1593 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA 1652
Query: 967 YTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDE-ECETCAEYLKQREEQCKRLKEAKI 1024
T+ E +K++E +LE +L ++ E + T + +EEQ R +E ++
Sbjct: 1653 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL 1712
Query: 1025 ALEIVDKLSNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
A E L Q ALE++ L + + + S + Q++ + + L
Sbjct: 1713 AAE----LHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768
Query: 1084 NAKLITICKK 1093
N L+ KK
Sbjct: 1769 NTGLLNQKKK 1778
Score = 45.6 bits (103), Expect = 0.001
Identities = 181/1024 (17%), Positives = 383/1024 (37%), Gaps = 64/1024 (6%)
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLS----NLIMENVTESDNLNKEVDDLKKNNECLTQ 180
E++ L +L K EL+E + +++ +L ++ E DNL D ++ L +
Sbjct: 904 ELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA----DAEERCHLLIK 959
Query: 181 KCIDLEKLVNE-SENKIGPKNICAQCKLKENLIQS--LHIGYDNTLSKLNRSISDSNTST 237
+ LE V E SE + + A + ++ + D KL + ++
Sbjct: 960 SKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQA 1019
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
NK+ L E+ A E L ++ +++ + ++ + ++++ + + + +
Sbjct: 1020 TENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAE-EDRVSALTKAKLRLEQ 1078
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+ +++ +L + ++ E K K D K + +V DA L+ D+ ++
Sbjct: 1079 QVEDLECSLEQEKKLRMDTERAKRKLEGD-LKLTQESVADAAQDKQQLEEKLKKKDSELS 1137
Query: 358 KYQIDLDE-------ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
+ + +++ + +K ++Q E EL++ A + Q E L
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 411 QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
+ E S+ K+E EL L +E L+ + L+ + + A +
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGR-LRRE-LEEAALRHEATVAALRRKQAEGAAEL--G 1253
Query: 471 ALITQYELSRTDYEIEKEKLRLET----GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
+ + R E EK +LR+E + + D L EA +V+
Sbjct: 1254 EQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVE 1313
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML-SLSEKDNKLTELV 585
L +L + + L ++L EE + L +++ + SL E +L E
Sbjct: 1314 ELQRQLADASTQRGRLQTESGELSRLL-EEKECLISQLSRGKALAAQSLEELRRQLEEES 1372
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+ L +L+ D++ RE+ + +E + Q + L K A++
Sbjct: 1373 KAKSALAHAVQALRHDCDLL-REQHEEEAEAQAELQRL------LSKANAEVAQWRSKYE 1425
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLE-----INIKTHEKTAEIQNRM 699
+EAK L L E+ E CS LE + ++ + T E++
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485
Query: 700 --IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
L K+ + ++ E+ + E+ + EA +R+ +L R + +
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP-KLDD 816
++ L+ +I ++ T V + + E +L++
Sbjct: 1546 TLKRENKNLQEEI-SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEE 1604
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
+ I + +++ +L +E +L+ ++ + + + + RLK
Sbjct: 1605 TKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLK 1664
Query: 877 KEKLS----LEQQVSNLKEQIRTQQPVER--QAKFADVAVNTDEDW---ANLH--SVVVD 925
K+ LE Q+ + Q Q R QA+ + DE+ A LH + ++
Sbjct: 1665 KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALE 1724
Query: 926 RMS--YDAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R + AE+E+ + ++ E R +Q+L ++ + T + + +L
Sbjct: 1725 RRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV-ALEK 1041
E+EE Q +E +E+ + E+ K+ ++ LE + K Q V L+
Sbjct: 1785 QLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1844
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANR 1101
++E + V A V +++ + QK K + ++R K A +
Sbjct: 1845 RLEEAEQAALRGGKKQVQKLEAKV--RELEAELDAEQKKHAEALKGVRKHERRVKELAYQ 1902
Query: 1102 ENED 1105
ED
Sbjct: 1903 AEED 1906
Score = 41.5 bits (93), Expect = 0.016
Identities = 50/216 (23%), Positives = 102/216 (47%), Gaps = 19/216 (8%)
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
A+ ++E +L ++ L+ + + ++ + V++ +++ L DAE
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 951
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
E+ L+K+ K L+ V ++ + +E + + + A+R++LED E ELK
Sbjct: 952 -ERCHLLIKS-------KVQLEGKVKELSERLEDEEEVNADLAARRRKLED---ECTELK 1000
Query: 993 QRYKELDEECETCAEYLKQR---EEQCKRLKEAKIAL-EIVDKLSNQKVAL-EKQIESLS 1047
K++D+ T A+ K++ E + K L E AL E V +L+ +K AL E ++L
Sbjct: 1001 ---KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALG 1057
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
+ + T + + QQ+ D+ ++ KK+
Sbjct: 1058 DLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKL 1093
>BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein.
Length = 1726
Score = 79.8 bits (188), Expect = 5e-14
Identities = 158/754 (20%), Positives = 312/754 (41%), Gaps = 80/754 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSAL---EGKYQNLILETQTRDLLMSQIKSLEMENLT 121
E ++ L L+ L EL +K + + Q + Q +L I + +L+
Sbjct: 844 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILT---NHLS 900
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQK 181
K KEI+ + +++ +E +++ ++++ E + L E+D +K N+ +K
Sbjct: 901 KQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAM---LRLEIDTIKNQNQEKEKK 957
Query: 182 CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK 241
C + K+V E + K I +E L Q++ Y+ LS L + N+ K
Sbjct: 958 CFEDLKIVKEKNEDL-QKTIKQN---EETLTQTIS-QYNGRLSVLTAENAMLNSKLENEK 1012
Query: 242 ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE 301
+ L+A E ++ E + + + E + + K +S
Sbjct: 1013 --QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSN 1070
Query: 302 IKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
+K N LS+QL ESK + I+ + DA +L + + D +++ Q
Sbjct: 1071 LKDNNEILSQQLFKTESKLNSLEIEFHHTR-----DA-LREKTLGLERVQKD--LSQTQC 1122
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-------QLIEKENACN-----ILR 409
+ E+ +KY Q +N+ + +SV E+L+ L S QL + N + ++
Sbjct: 1123 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1182
Query: 410 IQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKID----------IPRDLD 456
IQ ++ H I + + K+ E + L EC L + + + R L
Sbjct: 1183 IQ-DQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1241
Query: 457 QDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
Q+L K + +A + R + E E + L+ + G + +
Sbjct: 1242 QELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAE 1301
Query: 517 TLEEAHNEVKSLHEEL---TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
+++ +++ + +L K K++E NL + +E + LK + + +
Sbjct: 1302 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN 1361
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ-VIKQNGFELD- 631
L ++ K EL I G K N LK +TR+K + E S +K + FE+D
Sbjct: 1362 LDQEMKKNVELEREITGFK---NLLK-----MTRKKLNEYENGEFSFHGDLKTSQFEMDI 1413
Query: 632 ---KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK---EQCEEKTRDCSRLE-- 683
K+K I + + L E+ L++K ++CE+ ++ +LE
Sbjct: 1414 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQE 1473
Query: 684 -INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
IN+++H + ++ + + +++I+E + I ++ K L + +A A+ ++L
Sbjct: 1474 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQA------ASQENL 1527
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E RE N + K +E RI +LES++ +T+
Sbjct: 1528 EQFRE--NNFASMKSQMELRIKDLESELSKIKTS 1559
Score = 71.7 bits (168), Expect = 1e-11
Identities = 208/1099 (18%), Positives = 433/1099 (39%), Gaps = 90/1099 (8%)
Query: 64 KESSNE-INLKLEKLSGELFDIKEQKSALE---GKYQNLILETQTRDLLMSQIKSLE-ME 118
KES N + K L+G L + + S E + + + ++ + +QI+S++ ++
Sbjct: 642 KESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVD 701
Query: 119 NLTKDKEIKNLTDSLKTKSKK-----INELQEE-NDTLSNLIMENVTESDNLNKEVDDLK 172
+LT+ E + L S K I +L E D++S L +++ S + + +LK
Sbjct: 702 DLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSC---ERLLELK 758
Query: 173 KNN-ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
KN+ E LT K +E VN + ++ ++ K ++ ++ + ++ L L S++
Sbjct: 759 KNHCELLTVKIKKMEDKVNVLQREL------SETKEIKSQLEHQKVEWERELCSLRFSLN 812
Query: 232 DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEF 291
R TL ++ +E +K LEL + M+L N+
Sbjct: 813 QEEEKRR--NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV 870
Query: 292 ETKAVKVMSEIKRNLNS--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
+ ++ R N+ L + ++ N K K+ K + L
Sbjct: 871 VQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKN 930
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
++ I ++++D I + + + +C +LK V EK L + + E
Sbjct: 931 SMLQEEIAMLRLEIDTIKNQNQEKE---KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 987
Query: 410 IQKE-RIHEISSAVTIDIVKKENEL--KEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
Q R+ +++ + K ENE KE L E D DQ + +++
Sbjct: 988 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELE 1047
Query: 467 ILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE-EAHNEV 525
+ F + E SR ++K+ + K ++LE E H+
Sbjct: 1048 LAFQR--ARDECSRL-----QDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTR 1100
Query: 526 KSLHEELTKLYKSKVDENNANLNLI----KILSEEIDALKIAIAKNE--EKMLSLSEKDN 579
+L E+ L + + D + + K +E++ K I K E E+ LS + +N
Sbjct: 1101 DALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY-IGKQESVEERLSQLQSEN 1159
Query: 580 KLT--ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
L +L N + ++ ++ D + +E E+ ++++ EL +
Sbjct: 1160 MLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHL 1219
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ + L L + E SR IN++ ++T +++
Sbjct: 1220 KERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE--DETQDLKK 1277
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
++ +++ Q+QE E ++ + + L++D ++ + + +L QK+
Sbjct: 1278 KL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEEL--QKN 1334
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
L+ ++E E + + ++ + G +N KL++
Sbjct: 1335 LLNANLSEDEKE-QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEY 1393
Query: 818 PKRSISVISDSEVSQLKE--RLLSCQQELDDLKERYKELDDEC---ETCAEYLQER---- 868
S D + SQ + ++ + ++DDL + +C +T + LQE
Sbjct: 1394 ENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSM 1453
Query: 869 ---DEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVAVNTDE 914
++C +L+K K LEQ+V NL+ I + +Q +E +A+ ++A E
Sbjct: 1454 KTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR-QEIAEKLKE 1512
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
L + + + + E N MK+ ELR K DL++ ++K++ + E + K + E
Sbjct: 1513 VNLFLQAQAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELE- 1569
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS- 1033
+ K+ LE+ K + L + + +E L ++Q + L +++
Sbjct: 1570 KYKQLYLEELKVR-KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCV 1628
Query: 1034 ---NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKLI 1088
N + L +++ N +S S + S ++ +++N ++LK+ A+L
Sbjct: 1629 GNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELE 1688
Query: 1089 --TICKKRGKTGANRENED 1105
+I G T + N+D
Sbjct: 1689 SGSIASPLGSTDESNLNQD 1707
Score = 54.4 bits (125), Expect = 2e-06
Identities = 116/566 (20%), Positives = 237/566 (41%), Gaps = 51/566 (9%)
Query: 46 KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL----FDIKEQKSALEGKYQNLILE 101
+LQD +S +LK+++ ++ +L K +L + + AL K L LE
Sbjct: 1059 RLQDKMNFDVS-----NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK--TLGLE 1111
Query: 102 TQTRDLLMSQIKSLEMENLTKDKEIK--NLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
+DL +Q + EME +++++K ++ +++++LQ EN L + +
Sbjct: 1112 RVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 1171
Query: 160 ESDNLNKEVDDLKKNNECLTQKC---IDLEKLVNESENKIGPKNICAQCKLKENLIQSLH 216
++DN K V +++ + QK + + L+ E NK + C K ++ ++
Sbjct: 1172 KADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNK-ELISECNHLKERQYQYENEK 1230
Query: 217 IGYDNTLSKLNRSISDS-NTSTRYNKICTLQSELDAGRED-CKELCEDFTSIKNHLELHE 274
+ + +L + ++D+ + + S ED ++L + I+N L+ +
Sbjct: 1231 AEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQ 1290
Query: 275 PNMT--MDLDEKLGENNE-FETKAVKVMSEIKRNLNSLSE---QLIN-NESKKSKDHIDR 327
T + EK+ ++ + E K+ +K+ ++ + E L+N N S+ K+ + +
Sbjct: 1291 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKK 1350
Query: 328 ---YKDSLLAVLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLN----E 379
K SL LD E EI N++ + L+E GDL E
Sbjct: 1351 LMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFE 1410
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
++ + K+ L ++L + C L + + I+++E + + K
Sbjct: 1411 MDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQ------------ILQEELLSMKTVQK 1458
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKLRLETGTA 497
+C KL K K + +++ +L +H + ++ + QY E+ + EKL+
Sbjct: 1459 KCEKLQKNKKKLEQEV-INLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1517
Query: 498 KAVXXXXXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIK-ILSE 555
+A F +++ + +K L EL+K+ S+ D N L K + E
Sbjct: 1518 QAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLE 1577
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKL 581
E+ K +K + L+E + KL
Sbjct: 1578 ELKVRKSLSSKLTKTNERLAEVNTKL 1603
>AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein.
Length = 1710
Score = 79.8 bits (188), Expect = 5e-14
Identities = 158/754 (20%), Positives = 312/754 (41%), Gaps = 80/754 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSAL---EGKYQNLILETQTRDLLMSQIKSLEMENLT 121
E ++ L L+ L EL +K + + Q + Q +L I + +L+
Sbjct: 828 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILT---NHLS 884
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQK 181
K KEI+ + +++ +E +++ ++++ E + L E+D +K N+ +K
Sbjct: 885 KQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAM---LRLEIDTIKNQNQEKEKK 941
Query: 182 CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK 241
C + K+V E + K I +E L Q++ Y+ LS L + N+ K
Sbjct: 942 CFEDLKIVKEKNEDL-QKTIKQN---EETLTQTIS-QYNGRLSVLTAENAMLNSKLENEK 996
Query: 242 ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE 301
+ L+A E ++ E + + + E + + K +S
Sbjct: 997 --QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSN 1054
Query: 302 IKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
+K N LS+QL ESK + I+ + DA +L + + D +++ Q
Sbjct: 1055 LKDNNEILSQQLFKTESKLNSLEIEFHHTR-----DA-LREKTLGLERVQKD--LSQTQC 1106
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-------QLIEKENACN-----ILR 409
+ E+ +KY Q +N+ + +SV E+L+ L S QL + N + ++
Sbjct: 1107 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1166
Query: 410 IQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKID----------IPRDLD 456
IQ ++ H I + + K+ E + L EC L + + + R L
Sbjct: 1167 IQ-DQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1225
Query: 457 QDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
Q+L K + +A + R + E E + L+ + G + +
Sbjct: 1226 QELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAE 1285
Query: 517 TLEEAHNEVKSLHEEL---TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
+++ +++ + +L K K++E NL + +E + LK + + +
Sbjct: 1286 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN 1345
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ-VIKQNGFELD- 631
L ++ K EL I G K N LK +TR+K + E S +K + FE+D
Sbjct: 1346 LDQEMKKNVELEREITGFK---NLLK-----MTRKKLNEYENGEFSFHGDLKTSQFEMDI 1397
Query: 632 ---KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK---EQCEEKTRDCSRLE-- 683
K+K I + + L E+ L++K ++CE+ ++ +LE
Sbjct: 1398 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQE 1457
Query: 684 -INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
IN+++H + ++ + + +++I+E + I ++ K L + +A A+ ++L
Sbjct: 1458 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQA------ASQENL 1511
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E RE N + K +E RI +LES++ +T+
Sbjct: 1512 EQFRE--NNFASMKSQMELRIKDLESELSKIKTS 1543
Score = 71.7 bits (168), Expect = 1e-11
Identities = 208/1099 (18%), Positives = 433/1099 (39%), Gaps = 90/1099 (8%)
Query: 64 KESSNE-INLKLEKLSGELFDIKEQKSALE---GKYQNLILETQTRDLLMSQIKSLE-ME 118
KES N + K L+G L + + S E + + + ++ + +QI+S++ ++
Sbjct: 626 KESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVD 685
Query: 119 NLTKDKEIKNLTDSLKTKSKK-----INELQEE-NDTLSNLIMENVTESDNLNKEVDDLK 172
+LT+ E + L S K I +L E D++S L +++ S + + +LK
Sbjct: 686 DLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSC---ERLLELK 742
Query: 173 KNN-ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
KN+ E LT K +E VN + ++ ++ K ++ ++ + ++ L L S++
Sbjct: 743 KNHCELLTVKIKKMEDKVNVLQREL------SETKEIKSQLEHQKVEWERELCSLRFSLN 796
Query: 232 DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEF 291
R TL ++ +E +K LEL + M+L N+
Sbjct: 797 QEEEKRR--NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV 854
Query: 292 ETKAVKVMSEIKRNLNS--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
+ ++ R N+ L + ++ N K K+ K + L
Sbjct: 855 VQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKN 914
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
++ I ++++D I + + + +C +LK V EK L + + E
Sbjct: 915 SMLQEEIAMLRLEIDTIKNQNQEKE---KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 971
Query: 410 IQKE-RIHEISSAVTIDIVKKENEL--KEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
Q R+ +++ + K ENE KE L E D DQ + +++
Sbjct: 972 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELE 1031
Query: 467 ILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE-EAHNEV 525
+ F + E SR ++K+ + K ++LE E H+
Sbjct: 1032 LAFQR--ARDECSRL-----QDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTR 1084
Query: 526 KSLHEELTKLYKSKVDENNANLNLI----KILSEEIDALKIAIAKNE--EKMLSLSEKDN 579
+L E+ L + + D + + K +E++ K I K E E+ LS + +N
Sbjct: 1085 DALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY-IGKQESVEERLSQLQSEN 1143
Query: 580 KLT--ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
L +L N + ++ ++ D + +E E+ ++++ EL +
Sbjct: 1144 MLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHL 1203
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ + L L + E SR IN++ ++T +++
Sbjct: 1204 KERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE--DETQDLKK 1261
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
++ +++ Q+QE E ++ + + L++D ++ + + +L QK+
Sbjct: 1262 KL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEEL--QKN 1318
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
L+ ++E E + + ++ + G +N KL++
Sbjct: 1319 LLNANLSEDEKE-QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEY 1377
Query: 818 PKRSISVISDSEVSQLKE--RLLSCQQELDDLKERYKELDDEC---ETCAEYLQER---- 868
S D + SQ + ++ + ++DDL + +C +T + LQE
Sbjct: 1378 ENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSM 1437
Query: 869 ---DEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVAVNTDE 914
++C +L+K K LEQ+V NL+ I + +Q +E +A+ ++A E
Sbjct: 1438 KTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR-QEIAEKLKE 1496
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
L + + + + E N MK+ ELR K DL++ ++K++ + E + K + E
Sbjct: 1497 VNLFLQAQAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELE- 1553
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS- 1033
+ K+ LE+ K + L + + +E L ++Q + L +++
Sbjct: 1554 KYKQLYLEELKVR-KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCV 1612
Query: 1034 ---NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKLI 1088
N + L +++ N +S S + S ++ +++N ++LK+ A+L
Sbjct: 1613 GNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELE 1672
Query: 1089 --TICKKRGKTGANRENED 1105
+I G T + N+D
Sbjct: 1673 SGSIASPLGSTDESNLNQD 1691
Score = 54.4 bits (125), Expect = 2e-06
Identities = 116/566 (20%), Positives = 237/566 (41%), Gaps = 51/566 (9%)
Query: 46 KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL----FDIKEQKSALEGKYQNLILE 101
+LQD +S +LK+++ ++ +L K +L + + AL K L LE
Sbjct: 1043 RLQDKMNFDVS-----NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK--TLGLE 1095
Query: 102 TQTRDLLMSQIKSLEMENLTKDKEIK--NLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
+DL +Q + EME +++++K ++ +++++LQ EN L + +
Sbjct: 1096 RVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 1155
Query: 160 ESDNLNKEVDDLKKNNECLTQKC---IDLEKLVNESENKIGPKNICAQCKLKENLIQSLH 216
++DN K V +++ + QK + + L+ E NK + C K ++ ++
Sbjct: 1156 KADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNK-ELISECNHLKERQYQYENEK 1214
Query: 217 IGYDNTLSKLNRSISDS-NTSTRYNKICTLQSELDAGRED-CKELCEDFTSIKNHLELHE 274
+ + +L + ++D+ + + S ED ++L + I+N L+ +
Sbjct: 1215 AEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQ 1274
Query: 275 PNMT--MDLDEKLGENNE-FETKAVKVMSEIKRNLNSLSE---QLIN-NESKKSKDHIDR 327
T + EK+ ++ + E K+ +K+ ++ + E L+N N S+ K+ + +
Sbjct: 1275 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKK 1334
Query: 328 ---YKDSLLAVLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLN----E 379
K SL LD E EI N++ + L+E GDL E
Sbjct: 1335 LMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFE 1394
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
++ + K+ L ++L + C L + + I+++E + + K
Sbjct: 1395 MDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQ------------ILQEELLSMKTVQK 1442
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKLRLETGTA 497
+C KL K K + +++ +L +H + ++ + QY E+ + EKL+
Sbjct: 1443 KCEKLQKNKKKLEQEV-INLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1501
Query: 498 KAVXXXXXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIK-ILSE 555
+A F +++ + +K L EL+K+ S+ D N L K + E
Sbjct: 1502 QAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLE 1561
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKL 581
E+ K +K + L+E + KL
Sbjct: 1562 ELKVRKSLSSKLTKTNERLAEVNTKL 1587
>AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein.
Length = 2010
Score = 79.8 bits (188), Expect = 5e-14
Identities = 221/1076 (20%), Positives = 439/1076 (40%), Gaps = 110/1076 (10%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA 90
+ KND ++ Q+ L D+ + C L +S ++ K+++LS L D +E +
Sbjct: 958 QEKNDLALQLQAEQDNLADAE------ERCHLLIKSKVQLEGKVKELSERLEDEEEVNAD 1011
Query: 91 LEGKYQNLILE-TQTR---DLLMSQIKSLEMENLTKDKEIKNLTDSLK---------TKS 137
L + + L E T+ + D L + E E + ++KNLT+ + TK
Sbjct: 1012 LAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1071
Query: 138 KK---------INELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKL 188
KK + +LQ E D +S L + L ++V+DL+ + E + +D E+
Sbjct: 1072 KKALQEAHQQALGDLQAEEDRVSALTKAKL----RLEQQVEDLECSLEQEKKLRMDTERA 1127
Query: 189 VN--ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICT 244
E + K+ +++ + K+ L + L D+ LS+L+ + D + KI
Sbjct: 1128 KRKLEGDLKLTQESVADAAQDKQQLEEKLK-KKDSELSQLSLRVEDEQLLGAQMQKKI-- 1184
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV-------- 296
EL A E+ +E E + + +E +L+E L E E A
Sbjct: 1185 --KELQARAEELEEELEAERAARARVEKQRAEAARELEE-LSERLEEAGGASAGQREGCR 1241
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
K +E+ R L E + +E+ + + R + A L + SL ++
Sbjct: 1242 KREAELGRLRRELEEAALRHEATVAA--LRRKQAEGAAELGEQ--VDSLQRVRQKLEKEK 1297
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
++ ++++D++ + ++ ++L+ ++ E + Q+ R+
Sbjct: 1298 SELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ 1357
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
S ++ + +KE + ++ + L L+ ++ R L+++ A + AL
Sbjct: 1358 TESGELSRLLEEKECLISQLSRGKALAAQSLE-ELRRQLEEESKAKSALAHAVQALRHDC 1416
Query: 477 ELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL 535
+L R +E E E + L+ +KA EE K L L +
Sbjct: 1417 DLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1476
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
+ V+ NA K S E L++ ++E+ L L + T + ++ K++
Sbjct: 1477 -EEGVEAANA-----KCSSLEKAKLRLQ-TESEDVTLEL----ERATSAAAALD--KKQR 1523
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
+ ++L + +E+E Q ELE + + + G EL +++
Sbjct: 1524 HLERALEERRRQEEEMQ-RELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQ 1582
Query: 656 DEAKSLLEQ-NLALKEQCE-EKTR-----DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ 708
+E L +Q +L+ K E EKT+ + S ++ ++ E E++ +R+Q ++
Sbjct: 1583 EEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELS 1642
Query: 709 EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQKDLVEGRIA 764
+ + E + KL E + L+R++ AV+ L++S +A N+ K +EG +
Sbjct: 1643 Q---VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1699
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV 824
+LE + AT +E R E + + +R S+
Sbjct: 1700 DLELQL---GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1756
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKEL-DDECETCAEYLQERDEQCARLKKEKLSLE 883
++ +E+ +L+ L + ER + L + E E L Q L +K LE
Sbjct: 1757 LA-AELEELRAAL--------EQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLE 1807
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKT 942
++ L ++ R+A+ + A D A + + A +E+ K+ L +T
Sbjct: 1808 ADLAQLSGEVEEAAQERREAE--EKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQT 1865
Query: 943 IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEE 1001
+ EL+ + ++ + Q A+ K+ ++ EAK +ELE + AE ++ + K + +
Sbjct: 1866 VRELQARLEEAE------QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKH 1919
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
E Q EE K L + ++VDKL ++ + ++Q E +N Y
Sbjct: 1920 ERRVKELAYQAEEDRKNLARMQ---DLVDKLQSKVKSYKRQFEEAEQQANTNLAKY 1972
Score = 65.7 bits (153), Expect = 9e-10
Identities = 85/423 (20%), Positives = 171/423 (40%), Gaps = 28/423 (6%)
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
L+++C E +D LE+ + EK + + L +++ D+ + LT +
Sbjct: 1019 LEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDE-------SVARLTKE 1071
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
+AL+ + A+ DL++ + V+ LT K +E ++ +LE + E+ +
Sbjct: 1072 KKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKL 1131
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV-ISDSEV--SQLKERLLSCQQEL 844
+ + L E K DS +S+ + D ++ +Q+++++ Q
Sbjct: 1132 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1191
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
++L+E EL+ E A ++R E L E+LS + + + + +R+A+
Sbjct: 1192 EELEE---ELEAERAARARVEKQRAEAAREL--EELSERLEEAGGASAGQREGCRKREAE 1246
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAE-----VEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ +E + V AE E+ L + ++L +K +L+ V
Sbjct: 1247 LGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD 1306
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE---ECETCAEYLKQREEQC 1016
+ +E T+ E + ED +L E K + +EL + T L+ +
Sbjct: 1307 LAANVETLTRAKASAEKLCRTYED---QLSEAKIKVEELQRQLADASTQRGRLQTESGEL 1363
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
RL E K L + +LS K + +E L S A A+ + D+++E
Sbjct: 1364 SRLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 1421
Query: 1077 NQK 1079
+
Sbjct: 1422 QHE 1424
Score = 60.1 bits (139), Expect = 4e-08
Identities = 184/1002 (18%), Positives = 380/1002 (37%), Gaps = 55/1002 (5%)
Query: 73 KLEKLSGELFDIKEQKSALEGKYQNL----ILETQTRDLLMSQIKSLEMENLTKDKEIKN 128
+L L EL ++ +A E K Q L + TQ ++ L Q+++ E +NL +E +
Sbjct: 924 ELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQA-EQDNLADAEERCH 982
Query: 129 LTDSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
L K + + K+ EL E + + + L E +LKK+ + L EK
Sbjct: 983 LLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEK 1042
Query: 188 LVNESENKIGPKNICAQ-CKLKENLI------QSLHIGYDNTLSKLNRSISDSNTSTRYN 240
+ENK+ KN+ + L E++ ++L + L L + T+
Sbjct: 1043 EKQATENKV--KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1100
Query: 241 KICTLQSE-LDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
Q E L+ E K+L D K LE + + + + E K K
Sbjct: 1101 LRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKD 1160
Query: 300 SEIKR-NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
SE+ + +L EQL+ + +K + + L L+AE + ++ +
Sbjct: 1161 SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARA------RVEKQRAE 1214
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+L+E+ E+ + G + + ++ A L E E A +
Sbjct: 1215 AARELEELSERLEEAGG---ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRK 1271
Query: 419 SSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL 478
+ ++ ++ + L+ + K + S+L++++ DL ++ + + L YE
Sbjct: 1272 QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVD-DLAANVETLTRAKASAEKLCRTYED 1330
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV---KSLH----EE 531
++ +I+ E+L+ + A + E +++ K+L EE
Sbjct: 1331 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1390
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + + + +A + ++ L + D L+ + E L +K V+
Sbjct: 1391 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS- 1449
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
K E ++++ + + K+ A L+ + + ++ + ++ L
Sbjct: 1450 KYEADAIQRTEE-LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1508
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
A +L ++ L+ EE+ R ++ ++ ++ + + RL+ +E
Sbjct: 1509 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1568
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ + + L + L + K ++ + L +K ++ + E E +
Sbjct: 1569 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE 1628
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVS 831
E+T T+ +++ + + S+ D+E
Sbjct: 1629 LEETKTL------RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1682
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
E L ++ DL + +L E A+LK+E+ +++ E
Sbjct: 1683 ARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1742
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE-VEKNKRLMKTIEE---LR 947
Q +ER+A +A +E A L R + E +E +RL + L
Sbjct: 1743 LHEQAQALERRASL--LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1800
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELEELKQRYKELDEECETCA 1006
+K+ L+ + ++ +E+ ++ +E E K +K + D EELK+ ++ E
Sbjct: 1801 NQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMK 1859
Query: 1007 EYLKQ--REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ L+Q RE Q RL+EA+ A K QK LE ++ L
Sbjct: 1860 KTLEQTVRELQA-RLEEAEQAALRGGKKQVQK--LEAKVREL 1898
Score = 46.0 bits (104), Expect = 8e-04
Identities = 129/707 (18%), Positives = 263/707 (37%), Gaps = 45/707 (6%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI---KS 114
K+C++ ++ +E +K+E+L +L D Q+ L+ + L + ++ L+SQ+ K+
Sbjct: 1323 KLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKA 1382
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDL--K 172
L ++L + + + L + K KS + +Q +L+ E E E+ L K
Sbjct: 1383 LAAQSLEELR--RQLEEESKAKSALAHAVQALRHD-CDLLREQHEEEAEAQAELQRLLSK 1439
Query: 173 KNNECLTQKC-IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN-TLSKLNRSI 230
N E + + + + E + K + + + E +++ + + +KL
Sbjct: 1440 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1499
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
+ + + + + LD + + E+ E M +L+ E+
Sbjct: 1500 ESEDVTLELERATSAAAALDKKQRHLERALEE-------RRRQEEEMQRELEAAQRESRG 1552
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
T+ ++ + L +L + + E+K ++ I D + L + L+ +
Sbjct: 1553 LGTELFRLRHGHEEALEAL--ETLKRENKNLQEEISDLTDQV--SLSGK-SIQELEKTKK 1607
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
++ ++ Q L+E + EL V A ++ +L EK+ C LR
Sbjct: 1608 ALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK---AEVDRKLAEKDEECANLRR 1664
Query: 411 QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
+R E A + NE + K L+ L++ + Q A + T L
Sbjct: 1665 NHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEA-QAATRLMQ 1723
Query: 471 ALITQYELSRTDYEIEKEKLRLET-GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH 529
A + + + R E+++L E A+A+ LE+ +
Sbjct: 1724 AQLKEEQAGRD----EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1779
Query: 530 EEL---TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTELV 585
+EL T+ +N LN K L ++ L + + ++ EK K +T+
Sbjct: 1780 QELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAA 1839
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
LK+E ++ L + + + E EL+ + +Q K + L
Sbjct: 1840 MMAEELKKEQDTSAHL-ERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL 1898
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
E K E ALK + R L + K ++ +LQ
Sbjct: 1899 EAELDA-----EQKKHAE---ALK-GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQS 1949
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
+++ + F E E + N KY + + D A + + + N+L
Sbjct: 1950 KVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKL 1996
Score = 45.6 bits (103), Expect = 0.001
Identities = 146/790 (18%), Positives = 300/790 (37%), Gaps = 71/790 (8%)
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
D+D++ K + + +++K++ E++A+L+ + L +K+ + E
Sbjct: 1029 DIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVAR-------LTKEKKALQEAHQQ 1081
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-----KITILFDALITQY 476
D+ +E+ + LTK L+L + D+ L+Q+ K + D +TQ
Sbjct: 1082 ALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1140
Query: 477 ELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT- 533
++ D + +EKL+ + + ++E + L EEL
Sbjct: 1141 SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1200
Query: 534 -KLYKSKVDENNANL-NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
+ +++V++ A ++ LSE ++ A A E + +L + L
Sbjct: 1201 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEA-AL 1259
Query: 592 KEENN--SLKSLNDVITREKETQASELERSCQVIKQNGFEL----DKMKADILMXXXXXX 645
+ E +L+ E Q L+R Q +++ EL D + A++
Sbjct: 1260 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA 1319
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
D+ + L+ Q + + RL+ + E + +I +L +
Sbjct: 1320 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1379
Query: 706 ------QIQEDDKLFIEKETKLNE-LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
Q E+ + +E+E+K L + +AL+ D D + E EA +L
Sbjct: 1380 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1439
Query: 759 VEGRIAE----LESDI--RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+A+ E+D RTE+ E L
Sbjct: 1440 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1499
Query: 813 KLDDSP---KRSISVISDSEVSQ------LKERLLS---CQQELDDLKERYKELDDECET 860
+ +D +R+ S + + Q L+ER Q+EL+ + + L E
Sbjct: 1500 ESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFR 1559
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVA 909
+E E LK+E +L++++S+L +Q+ +T++ +E + A
Sbjct: 1560 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1619
Query: 910 VNTDEDWANLHSVVVDRMSYD---AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
+ E L R+ + + E +++L + EE +++ + V +Q +++
Sbjct: 1620 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA 1679
Query: 967 YTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDE-ECETCAEYLKQREEQCKRLKEAKI 1024
T+ E +K++E +LE +L ++ E + T + +EEQ R +E ++
Sbjct: 1680 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL 1739
Query: 1025 ALEIVDKLSNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
A E L Q ALE++ L + + + S + Q++ + + L
Sbjct: 1740 AAE----LHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1795
Query: 1084 NAKLITICKK 1093
N L+ KK
Sbjct: 1796 NTGLLNQKKK 1805
Score = 44.0 bits (99), Expect = 0.003
Identities = 121/659 (18%), Positives = 243/659 (36%), Gaps = 42/659 (6%)
Query: 478 LSRTDYEIEKEK--LRLET----GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
L R ++EKEK LR+E + + D L EA +V+ L +
Sbjct: 1286 LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 1345
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML-SLSEKDNKLTELVSTING 590
L + + L ++L EE + L +++ + SL E +L E +
Sbjct: 1346 LADASTQRGRLQTESGELSRLL-EEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSA 1404
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L +L+ D++ RE+ + +E + Q + L K A++
Sbjct: 1405 LAHAVQALRHDCDLL-REQHEEEAEAQAELQRL------LSKANAEVAQWRSKYEADAIQ 1457
Query: 651 XXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLE-----INIKTHEKTAEIQNRM--IMR 702
+EAK L L E+ E CS LE + ++ + T E++
Sbjct: 1458 RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAA 1517
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
L K+ + ++ E+ + E+ + EA +R+ +L R + + ++
Sbjct: 1518 LDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRE 1577
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP-KLDDSPKRS 821
L+ +I ++ T V + + E +L+++
Sbjct: 1578 NKNLQEEI-SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLR 1636
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
I + +++ +L +E +L+ ++ + + + + RLKK+
Sbjct: 1637 IQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEG 1696
Query: 882 ----LEQQVSNLKEQIRTQQPVER--QAKFADVAVNTDEDW---ANLH--SVVVDRMS-- 928
LE Q+ + Q Q R QA+ + DE+ A LH + ++R +
Sbjct: 1697 DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1756
Query: 929 YDAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
AE+E+ + ++ E R +Q+L ++ + T + + +L E
Sbjct: 1757 LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE 1816
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV-ALEKQIESL 1046
+EE Q +E +E+ + E+ K+ ++ LE + K Q V L+ ++E
Sbjct: 1817 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA 1876
Query: 1047 SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENED 1105
+ V A V +++ + QK K + ++R K A + ED
Sbjct: 1877 EQAALRGGKKQVQKLEAKV--RELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEED 1933
Score = 32.7 bits (71), Expect = 7.5
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K + L +T + +K DL ++Q + ++ K + +++EL +R
Sbjct: 945 KRQELEETHVSITQEKNDL---ALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSER 1001
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESLS 1047
++ +E A ++ E++C LK+ LE+ + K +K A E ++++L+
Sbjct: 1002 LEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLT 1055
>AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein.
Length = 1715
Score = 79.8 bits (188), Expect = 5e-14
Identities = 158/754 (20%), Positives = 312/754 (41%), Gaps = 80/754 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSAL---EGKYQNLILETQTRDLLMSQIKSLEMENLT 121
E ++ L L+ L EL +K + + Q + Q +L I + +L+
Sbjct: 833 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILT---NHLS 889
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQK 181
K KEI+ + +++ +E +++ ++++ E + L E+D +K N+ +K
Sbjct: 890 KQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAM---LRLEIDTIKNQNQEKEKK 946
Query: 182 CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK 241
C + K+V E + K I +E L Q++ Y+ LS L + N+ K
Sbjct: 947 CFEDLKIVKEKNEDL-QKTIKQN---EETLTQTIS-QYNGRLSVLTAENAMLNSKLENEK 1001
Query: 242 ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE 301
+ L+A E ++ E + + + E + + K +S
Sbjct: 1002 --QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSN 1059
Query: 302 IKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
+K N LS+QL ESK + I+ + DA +L + + D +++ Q
Sbjct: 1060 LKDNNEILSQQLFKTESKLNSLEIEFHHTR-----DA-LREKTLGLERVQKD--LSQTQC 1111
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-------QLIEKENACN-----ILR 409
+ E+ +KY Q +N+ + +SV E+L+ L S QL + N + ++
Sbjct: 1112 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1171
Query: 410 IQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKID----------IPRDLD 456
IQ ++ H I + + K+ E + L EC L + + + R L
Sbjct: 1172 IQ-DQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1230
Query: 457 QDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
Q+L K + +A + R + E E + L+ + G + +
Sbjct: 1231 QELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAE 1290
Query: 517 TLEEAHNEVKSLHEEL---TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
+++ +++ + +L K K++E NL + +E + LK + + +
Sbjct: 1291 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN 1350
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ-VIKQNGFELD- 631
L ++ K EL I G K N LK +TR+K + E S +K + FE+D
Sbjct: 1351 LDQEMKKNVELEREITGFK---NLLK-----MTRKKLNEYENGEFSFHGDLKTSQFEMDI 1402
Query: 632 ---KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK---EQCEEKTRDCSRLE-- 683
K+K I + + L E+ L++K ++CE+ ++ +LE
Sbjct: 1403 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQE 1462
Query: 684 -INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
IN+++H + ++ + + +++I+E + I ++ K L + +A A+ ++L
Sbjct: 1463 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQA------ASQENL 1516
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E RE N + K +E RI +LES++ +T+
Sbjct: 1517 EQFRE--NNFASMKSQMELRIKDLESELSKIKTS 1548
Score = 71.7 bits (168), Expect = 1e-11
Identities = 208/1099 (18%), Positives = 433/1099 (39%), Gaps = 90/1099 (8%)
Query: 64 KESSNE-INLKLEKLSGELFDIKEQKSALE---GKYQNLILETQTRDLLMSQIKSLE-ME 118
KES N + K L+G L + + S E + + + ++ + +QI+S++ ++
Sbjct: 631 KESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVD 690
Query: 119 NLTKDKEIKNLTDSLKTKSKK-----INELQEE-NDTLSNLIMENVTESDNLNKEVDDLK 172
+LT+ E + L S K I +L E D++S L +++ S + + +LK
Sbjct: 691 DLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSC---ERLLELK 747
Query: 173 KNN-ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
KN+ E LT K +E VN + ++ ++ K ++ ++ + ++ L L S++
Sbjct: 748 KNHCELLTVKIKKMEDKVNVLQREL------SETKEIKSQLEHQKVEWERELCSLRFSLN 801
Query: 232 DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEF 291
R TL ++ +E +K LEL + M+L N+
Sbjct: 802 QEEEKRR--NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV 859
Query: 292 ETKAVKVMSEIKRNLNS--LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
+ ++ R N+ L + ++ N K K+ K + L
Sbjct: 860 VQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKN 919
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
++ I ++++D I + + + +C +LK V EK L + + E
Sbjct: 920 SMLQEEIAMLRLEIDTIKNQNQEKE---KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 976
Query: 410 IQKE-RIHEISSAVTIDIVKKENEL--KEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
Q R+ +++ + K ENE KE L E D DQ + +++
Sbjct: 977 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELE 1036
Query: 467 ILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE-EAHNEV 525
+ F + E SR ++K+ + K ++LE E H+
Sbjct: 1037 LAFQR--ARDECSRL-----QDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTR 1089
Query: 526 KSLHEELTKLYKSKVDENNANLNLI----KILSEEIDALKIAIAKNE--EKMLSLSEKDN 579
+L E+ L + + D + + K +E++ K I K E E+ LS + +N
Sbjct: 1090 DALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY-IGKQESVEERLSQLQSEN 1148
Query: 580 KLT--ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
L +L N + ++ ++ D + +E E+ ++++ EL +
Sbjct: 1149 MLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHL 1208
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ + L L + E SR IN++ ++T +++
Sbjct: 1209 KERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLE--DETQDLKK 1266
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
++ +++ Q+QE E ++ + + L++D ++ + + +L QK+
Sbjct: 1267 KL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEEL--QKN 1323
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
L+ ++E E + + ++ + G +N KL++
Sbjct: 1324 LLNANLSEDEKE-QLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEY 1382
Query: 818 PKRSISVISDSEVSQLKE--RLLSCQQELDDLKERYKELDDEC---ETCAEYLQER---- 868
S D + SQ + ++ + ++DDL + +C +T + LQE
Sbjct: 1383 ENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSM 1442
Query: 869 ---DEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVAVNTDE 914
++C +L+K K LEQ+V NL+ I + +Q +E +A+ ++A E
Sbjct: 1443 KTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR-QEIAEKLKE 1501
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
L + + + + E N MK+ ELR K DL++ ++K++ + E + K + E
Sbjct: 1502 VNLFLQAQAASQENLEQFRENNFASMKSQMELRIK--DLESELSKIKTSQEDFNKTELE- 1558
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS- 1033
+ K+ LE+ K + L + + +E L ++Q + L +++
Sbjct: 1559 KYKQLYLEELKVR-KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCV 1617
Query: 1034 ---NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKLI 1088
N + L +++ N +S S + S ++ +++N ++LK+ A+L
Sbjct: 1618 GNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELE 1677
Query: 1089 --TICKKRGKTGANRENED 1105
+I G T + N+D
Sbjct: 1678 SGSIASPLGSTDESNLNQD 1696
Score = 54.4 bits (125), Expect = 2e-06
Identities = 116/566 (20%), Positives = 237/566 (41%), Gaps = 51/566 (9%)
Query: 46 KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL----FDIKEQKSALEGKYQNLILE 101
+LQD +S +LK+++ ++ +L K +L + + AL K L LE
Sbjct: 1048 RLQDKMNFDVS-----NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK--TLGLE 1100
Query: 102 TQTRDLLMSQIKSLEMENLTKDKEIK--NLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
+DL +Q + EME +++++K ++ +++++LQ EN L + +
Sbjct: 1101 RVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 1160
Query: 160 ESDNLNKEVDDLKKNNECLTQKC---IDLEKLVNESENKIGPKNICAQCKLKENLIQSLH 216
++DN K V +++ + QK + + L+ E NK + C K ++ ++
Sbjct: 1161 KADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNK-ELISECNHLKERQYQYENEK 1219
Query: 217 IGYDNTLSKLNRSISDS-NTSTRYNKICTLQSELDAGRED-CKELCEDFTSIKNHLELHE 274
+ + +L + ++D+ + + S ED ++L + I+N L+ +
Sbjct: 1220 AEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQ 1279
Query: 275 PNMT--MDLDEKLGENNE-FETKAVKVMSEIKRNLNSLSE---QLIN-NESKKSKDHIDR 327
T + EK+ ++ + E K+ +K+ ++ + E L+N N S+ K+ + +
Sbjct: 1280 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKK 1339
Query: 328 ---YKDSLLAVLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLN----E 379
K SL LD E EI N++ + L+E GDL E
Sbjct: 1340 LMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFE 1399
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
++ + K+ L ++L + C L + + I+++E + + K
Sbjct: 1400 MDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQ------------ILQEELLSMKTVQK 1447
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKLRLETGTA 497
+C KL K K + +++ +L +H + ++ + QY E+ + EKL+
Sbjct: 1448 KCEKLQKNKKKLEQEV-INLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1506
Query: 498 KAVXXXXXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIK-ILSE 555
+A F +++ + +K L EL+K+ S+ D N L K + E
Sbjct: 1507 QAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLE 1566
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKL 581
E+ K +K + L+E + KL
Sbjct: 1567 ELKVRKSLSSKLTKTNERLAEVNTKL 1592
>AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1773
Score = 79.4 bits (187), Expect = 7e-14
Identities = 205/1052 (19%), Positives = 425/1052 (40%), Gaps = 108/1052 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
++ S + ++E+L + D+ ++K +LE + + L Q R I +E+L
Sbjct: 793 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDG-NVESLMT 851
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNECL 178
+ EI+ SLK ++E++ TL E + E+D L E + K+ +
Sbjct: 852 ELEIEK---SLKHHEDIVDEIECIEKTLLKRRSE-LREADRLLAEAESELSCTKEKTKNA 907
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTST 237
+K D ++ + ++E+ AQ + NL+++ D L L D
Sbjct: 908 VEKFTDAKRSLLQTESDAEELERRAQ-ETAVNLVKA-----DQQLRSLQADAKDLEQHKI 961
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAV 296
+ +I +++ A ++ DF + E L E + D ++ E NE V
Sbjct: 962 KQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV 1015
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
SE+ Q E +K K + + + AVLD + G ++ L+ +
Sbjct: 1016 LKESEVLL-------QAKRAELEKLKSQVTSQQQEM-AVLDRQLGHKKEELH--LLQGSM 1065
Query: 357 NKYQIDLDEILE----KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + DL E L + T+ + E S L+ ++ + LN Q+ E++ +++ +
Sbjct: 1066 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1125
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
E+ E V + K + ELK IL + L+L ++ + + + D
Sbjct: 1126 EKEEENLQVVLRQMSKHKTELKNIL--DMLQLENHEL-------------QGLKLQHDQR 1170
Query: 473 ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT--LEEAHNEVKSLHE 530
++ EL +T + +EKL LE + D +E E ++L
Sbjct: 1171 VS--ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1228
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+ L K K D L E+ D + +A+ + ++L+ +E+++K+ + S +
Sbjct: 1229 CVECLSKEKED-----------LQEKCDIWEKKLAQTK-RVLAAAEENSKMEQ--SNLEK 1274
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L+ L+ D + R+K + +++ Q +++ ++ ++ ++
Sbjct: 1275 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------ANVQDHL 1328
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
D + Q++ L EQ + +D S + +K E + + + LQ +I+E+
Sbjct: 1329 NLAKQDLLHTTKHQDVLLSEQTRLQ-KDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1387
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREAVNQLTTQK---DLVEGRIAEL 766
+++E L + E+ + + + L E + +LT QK D V ++
Sbjct: 1388 KLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAA 1447
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI- 825
E +RT Q +++ +L K DS + S++
Sbjct: 1448 EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR 1507
Query: 826 ---------SDSEVSQLKERLLSCQQELD-DLKERYKE---LDDECETCAEYLQERDEQC 872
++ +V+ LKE L + +L+ +L E+ +E + E T Q+ E+
Sbjct: 1508 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 1567
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RMSYD 930
RL KE ++ + + LK+Q+ Q+ +ER+ A+ T L S V D R S
Sbjct: 1568 RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT------LKSEVKDEIRTSLK 1621
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ L +E + + ++L+ + +++ + +T + FE K L + + +
Sbjct: 1622 NLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEEK---LNFSQVHIMD 1677
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
R + L E+ + LK + C K+A++ ++ + +L +Q+++L
Sbjct: 1678 EHWRGEALREKLRHREDRLKAQLRHCMS-KQAEVLIKGKRQTEGTLHSLRRQVDALGELV 1736
Query: 1051 VSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
S S ++ S +T+ + Q +K
Sbjct: 1737 TSTSADSASSPSLSQLESSLTEDSQLGQNQEK 1768
Score = 53.2 bits (122), Expect = 5e-06
Identities = 101/547 (18%), Positives = 211/547 (38%), Gaps = 35/547 (6%)
Query: 551 KILSEEI--DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
KI EEI + KI AK+ + LS+K KLTE E L+ ++ R
Sbjct: 960 KIKQEEILKEINKIVAAKDSD-FQCLSKKKEKLTE----------ELQKLQKDIEMAERN 1008
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
++ L+ S +++ EL+K+K+ + +E L +
Sbjct: 1009 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1068
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K +E R E+ K + E+++ ++ L Q E + E++T+L + +
Sbjct: 1069 KADLQEALR-LGETEVTEKCNH-IREVKS-LLEELSFQKGELNVQISERKTQLTLIKQEI 1125
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E + + ++ + + + + D+++ EL+ ++ + V
Sbjct: 1126 EKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQG-LKLQHDQRVSELEKTQVAV 1181
Query: 789 XXXXXXXXXXXTFGDENR-DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + ++ +L + KR I ++ L SC + L
Sbjct: 1182 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-----RMTAESRALQSCVECLSKE 1236
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
KE +L ++C+ + L + A ++ + + L+ +R Q Q
Sbjct: 1237 KE---DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1293
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
++++ D A + R + ++ E+ L + L KQDL +T + +
Sbjct: 1294 LSLHNDIS-AMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1349
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
T+ K+ EDC+ E E +Q+ + L E E L Q+E +RL++ + + E
Sbjct: 1350 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1409
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
KL KV L++Q L + S ++ ++ ++E ++ + K
Sbjct: 1410 --SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 1467
Query: 1088 ITICKKR 1094
++ K++
Sbjct: 1468 LSQTKRQ 1474
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 14/209 (6%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE---QQV 886
+S L+E L + + + + ++L DE ET + L E +++ +L+ + E +++
Sbjct: 66 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 125
Query: 887 SNLKEQIRTQQPVER--QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
+ L+ ++ Q V Q D++ E A L+ + E+EK RL + +
Sbjct: 126 AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 185
Query: 945 -----ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
EL ++Q LKN + K Q + EK +++ E AK K L+D + LKQ+ K+
Sbjct: 186 SALQAELEKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQD---DNNLLKQQLKDFQ 241
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ L + EE R+ E + L++
Sbjct: 242 NHLNHVVDGLVRPEEVAARVDELRRKLKL 270
Score = 48.0 bits (109), Expect = 2e-04
Identities = 150/790 (18%), Positives = 316/790 (40%), Gaps = 59/790 (7%)
Query: 2 LNNDNRIMFXXXXXXXXXXXXXRNQLDGAKSKNDNIIETQSNPIKLQDSG--TITISCKM 59
L +R++ +N ++ ++++T+S+ +L+ T K
Sbjct: 883 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 942
Query: 60 CQSLKE-SSNEINLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQ--TRDLLMSQIKS 114
Q L+ ++ +L+ K+ E L +I + +A + +Q L + + T +L Q K
Sbjct: 943 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ-KD 1001
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+EM +D ++ L +S K EL++ +++ E L + ++L
Sbjct: 1002 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1061
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN 234
+ Q DL++ + E ++ K C + ++L++ L +LN IS+
Sbjct: 1062 QGSMVQAKADLQEALRLGETEVTEK--CNHIREVKSLLEELSF----QKGELNVQISERK 1115
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKN-----HLELHE-PNMTMDLDEKLGEN 288
T K ++ E + + +++ + T +KN LE HE + + D+++ E
Sbjct: 1116 TQLTLIK-QEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL 1174
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ + ++ E++ NL +S+Q E + K ++R K + + AE V
Sbjct: 1175 EKTQVAVLEEKLELE-NLQQISQQQ-KGEIEWQKQLLERDKRE-IERMTAESRALQSCVE 1231
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + D+ E TK E S+++ N + LN + +++E + L
Sbjct: 1232 CLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQE--LDQL 1289
Query: 409 RIQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKK 464
K +H SA+ + +K N L+E L L+ K D+ QD+ ++
Sbjct: 1290 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1349
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D I+++ D + E+E + + + F L+
Sbjct: 1350 TRLQKD--ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ----- 1402
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKIAIAKNEEKMLSLSEKDNKL 581
K E +KL SKV L K L+++ +D + + EE++ +L E++
Sbjct: 1403 -KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC 1461
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
L T++ K + E+E Q E +++ E D M+AD +
Sbjct: 1462 ESLEKTLSQTKRQ-----------LSEREQQLVEKSGELLALQK---EADSMRADFSLLR 1507
Query: 642 XXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
K L+ Q L++ E+ ++ S ++ + T E A+ +
Sbjct: 1508 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 1567
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
RL K++ + + E + ++ E + + A++ L+S E +++ T +
Sbjct: 1568 RRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS--EVKDEIRTSLKNLN 1624
Query: 761 GRIAELESDI 770
+ EL +D+
Sbjct: 1625 QFLPELPADL 1634
Score = 46.4 bits (105), Expect = 6e-04
Identities = 51/213 (23%), Positives = 92/213 (43%), Gaps = 8/213 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
++EVS+L++ + Q L K + + + ++E L +EK SLE +V
Sbjct: 770 ENEVSRLEDIM----QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 825
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEE 945
L RT Q ++Q F D V + + + E+E K L+K E
Sbjct: 826 EELH---RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 882
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
LR + L +++ EK ++F ++ L +++ EEL++R +E
Sbjct: 883 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 942
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ L+ + K L++ KI E + K N+ VA
Sbjct: 943 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 975
Score = 35.9 bits (79), Expect = 0.80
Identities = 92/453 (20%), Positives = 177/453 (39%), Gaps = 37/453 (8%)
Query: 329 KDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE----- 383
K+ L +++ ++ + EIL + I K ++ ++ E+ T+ Q NE +
Sbjct: 8 KEQQLDIMNKQYQQLESRLDEIL--SRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 65
Query: 384 LKSVNEKLASLNSQLIEKENACNILRIQKE----RIHEIS---SAVTIDIVKKENELKEI 436
+ + E L ++ Q + +N C LR +KE R+ E+ + I + EN KE+
Sbjct: 66 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 125
Query: 437 LTKECLKLSKLKIDIPRDLDQ-DLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLE 493
E + +++ Q DL A+ + + + E ++ E+EK +LE
Sbjct: 126 AELESALQEQHEVNASLQQTQGDLSAY-EAELEARLNLRDAEANQLKEELEKVTRLTQLE 184
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
+A EE E LH +L L D+NN +K
Sbjct: 185 QSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDF 240
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
++ + + + EE + E KL +N + KSL D+ + E A
Sbjct: 241 QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA 300
Query: 614 -SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
S+ ER +++ + + + Q+ A +Q
Sbjct: 301 RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQM 360
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF-----IEKETKLNELTNK 727
E + L+ N+K+ E EIQ ++LQ+ +E +++ +EK+ KL + ++
Sbjct: 361 E---NEIHYLQENLKSME---EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQ 414
Query: 728 YE--ALKRDYDAAVKDLESS-REAVNQLTTQKD 757
+ L ++ K + +S + A +LT KD
Sbjct: 415 EQVFGLDKELKKLKKAVATSDKLATAELTIAKD 447
>AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110kDa
protein.
Length = 2325
Score = 79.4 bits (187), Expect = 7e-14
Identities = 205/1052 (19%), Positives = 425/1052 (40%), Gaps = 108/1052 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
++ S + ++E+L + D+ ++K +LE + + L Q R I +E+L
Sbjct: 1345 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDG-NVESLMT 1403
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNECL 178
+ EI+ SLK ++E++ TL E + E+D L E + K+ +
Sbjct: 1404 ELEIEK---SLKHHEDIVDEIECIEKTLLKRRSE-LREADRLLAEAESELSCTKEKTKNA 1459
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTST 237
+K D ++ + ++E+ AQ + NL+++ D L L D
Sbjct: 1460 VEKFTDAKRSLLQTESDAEELERRAQ-ETAVNLVKA-----DQQLRSLQADAKDLEQHKI 1513
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAV 296
+ +I +++ A ++ DF + E L E + D ++ E NE V
Sbjct: 1514 KQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV 1567
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
SE+ Q E +K K + + + AVLD + G ++ L+ +
Sbjct: 1568 LKESEVLL-------QAKRAELEKLKSQVTSQQQEM-AVLDRQLGHKKEELH--LLQGSM 1617
Query: 357 NKYQIDLDEILE----KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + DL E L + T+ + E S L+ ++ + LN Q+ E++ +++ +
Sbjct: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
E+ E V + K + ELK IL + L+L ++ + + + D
Sbjct: 1678 EKEEENLQVVLRQMSKHKTELKNIL--DMLQLENHEL-------------QGLKLQHDQR 1722
Query: 473 ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT--LEEAHNEVKSLHE 530
++ EL +T + +EKL LE + D +E E ++L
Sbjct: 1723 VS--ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+ L K K D L E+ D + +A+ + ++L+ +E+++K+ + S +
Sbjct: 1781 CVECLSKEKED-----------LQEKCDIWEKKLAQTK-RVLAAAEENSKMEQ--SNLEK 1826
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L+ L+ D + R+K + +++ Q +++ ++ ++ ++
Sbjct: 1827 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------ANVQDHL 1880
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
D + Q++ L EQ + +D S + +K E + + + LQ +I+E+
Sbjct: 1881 NLAKQDLLHTTKHQDVLLSEQTRLQ-KDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1939
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREAVNQLTTQK---DLVEGRIAEL 766
+++E L + E+ + + + L E + +LT QK D V ++
Sbjct: 1940 KLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAA 1999
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI- 825
E +RT Q +++ +L K DS + S++
Sbjct: 2000 EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR 2059
Query: 826 ---------SDSEVSQLKERLLSCQQELD-DLKERYKE---LDDECETCAEYLQERDEQC 872
++ +V+ LKE L + +L+ +L E+ +E + E T Q+ E+
Sbjct: 2060 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 2119
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RMSYD 930
RL KE ++ + + LK+Q+ Q+ +ER+ A+ T L S V D R S
Sbjct: 2120 RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT------LKSEVKDEIRTSLK 2173
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ L +E + + ++L+ + +++ + +T + FE K L + + +
Sbjct: 2174 NLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEEK---LNFSQVHIMD 2229
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
R + L E+ + LK + C K+A++ ++ + +L +Q+++L
Sbjct: 2230 EHWRGEALREKLRHREDRLKAQLRHCMS-KQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
Query: 1051 VSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
S S ++ S +T+ + Q +K
Sbjct: 2289 TSTSADSASSPSLSQLESSLTEDSQLGQNQEK 2320
Score = 54.4 bits (125), Expect = 2e-06
Identities = 108/561 (19%), Positives = 239/561 (42%), Gaps = 59/561 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
+++ L+ K+ K + EN NL + + EI+ + + + K + + L+ K NK++
Sbjct: 148 KLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISS 207
Query: 584 L--VSTINGLKEENNSLKSLNDVITREKETQASELE-RSCQVI---------KQNGF--- 628
L +S + L++ + + N V+T Q + RS + + +Q F
Sbjct: 208 LQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERF 267
Query: 629 ---ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN 685
E+++++ D+ +E K+ + N +LKE+ + + C L+ +
Sbjct: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
Query: 686 IKTHEKTAEIQNRMIMR-LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD--- 741
+ T + + + + R QKQ + + +L K E N Y + + D A +
Sbjct: 328 LNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ SR N T+ +++ A + ++
Sbjct: 388 IGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPL------------ 435
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE--RYKELDDE-C 858
+ L + K + + +S + D E+ + ++++L +E L+E + K++ +
Sbjct: 436 ---DTQLEDKEKKISAAQTRLSELHD-EIEKAEQQILRATEEFKQLEEAIQLKKISEAGK 491
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ + L R + +L++E L LE Q+ K++I +Q ++ K +A+++ +
Sbjct: 492 DLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQ---KEIKDLQIAIDSLDSKDP 548
Query: 919 LHSVVVDRMS-----YDAEVEKNKRLMKTIEEL--RYKKQ-----DLKNTVTKMQKAMEK 966
HS + + S D ++ ++L ++E+ R K+ DL+ +T+ Q A +
Sbjct: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
Query: 967 YTKKDKE--FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
KKD E ++ L K + + + ++L +E ET + L + E++ +L+ +
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 1025 ALEIVDK-LSNQKVALEKQIE 1044
E + K L+ + AL++Q E
Sbjct: 669 DAENMRKELAELESALQEQHE 689
Score = 53.2 bits (122), Expect = 5e-06
Identities = 101/547 (18%), Positives = 211/547 (38%), Gaps = 35/547 (6%)
Query: 551 KILSEEI--DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
KI EEI + KI AK+ + LS+K KLTE E L+ ++ R
Sbjct: 1512 KIKQEEILKEINKIVAAKDSD-FQCLSKKKEKLTE----------ELQKLQKDIEMAERN 1560
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
++ L+ S +++ EL+K+K+ + +E L +
Sbjct: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K +E R E+ K + E+++ ++ L Q E + E++T+L + +
Sbjct: 1621 KADLQEALR-LGETEVTEKCNH-IREVKS-LLEELSFQKGELNVQISERKTQLTLIKQEI 1677
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E + + ++ + + + + D+++ EL+ ++ + V
Sbjct: 1678 EKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQG-LKLQHDQRVSELEKTQVAV 1733
Query: 789 XXXXXXXXXXXTFGDENR-DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + ++ +L + KR I ++ L SC + L
Sbjct: 1734 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-----RMTAESRALQSCVECLSKE 1788
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
KE +L ++C+ + L + A ++ + + L+ +R Q Q
Sbjct: 1789 KE---DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
++++ D A + R + ++ E+ L + L KQDL +T + +
Sbjct: 1846 LSLHNDIS-AMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
T+ K+ EDC+ E E +Q+ + L E E L Q+E +RL++ + + E
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
KL KV L++Q L + S ++ ++ ++E ++ + K
Sbjct: 1962 --SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 2019
Query: 1088 ITICKKR 1094
++ K++
Sbjct: 2020 LSQTKRQ 2026
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 14/209 (6%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE---QQV 886
+S L+E L + + + + ++L DE ET + L E +++ +L+ + E +++
Sbjct: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
Query: 887 SNLKEQIRTQQPVER--QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
+ L+ ++ Q V Q D++ E A L+ + E+EK RL + +
Sbjct: 678 AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
Query: 945 -----ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
EL ++Q LKN + K Q + EK +++ E AK K L+D + LKQ+ K+
Sbjct: 738 SALQAELEKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQD---DNNLLKQQLKDFQ 793
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ L + EE R+ E + L++
Sbjct: 794 NHLNHVVDGLVRPEEVAARVDELRRKLKL 822
Score = 48.0 bits (109), Expect = 2e-04
Identities = 150/790 (18%), Positives = 316/790 (40%), Gaps = 59/790 (7%)
Query: 2 LNNDNRIMFXXXXXXXXXXXXXRNQLDGAKSKNDNIIETQSNPIKLQDSG--TITISCKM 59
L +R++ +N ++ ++++T+S+ +L+ T K
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
Query: 60 CQSLKE-SSNEINLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQ--TRDLLMSQIKS 114
Q L+ ++ +L+ K+ E L +I + +A + +Q L + + T +L Q K
Sbjct: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ-KD 1553
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+EM +D ++ L +S K EL++ +++ E L + ++L
Sbjct: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN 234
+ Q DL++ + E ++ K C + ++L++ L +LN IS+
Sbjct: 1614 QGSMVQAKADLQEALRLGETEVTEK--CNHIREVKSLLEELSF----QKGELNVQISERK 1667
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKN-----HLELHE-PNMTMDLDEKLGEN 288
T K ++ E + + +++ + T +KN LE HE + + D+++ E
Sbjct: 1668 TQLTLIK-QEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL 1726
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ + ++ E++ NL +S+Q E + K ++R K + + AE V
Sbjct: 1727 EKTQVAVLEEKLELE-NLQQISQQQ-KGEIEWQKQLLERDKRE-IERMTAESRALQSCVE 1783
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + D+ E TK E S+++ N + LN + +++E + L
Sbjct: 1784 CLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQE--LDQL 1841
Query: 409 RIQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKK 464
K +H SA+ + +K N L+E L L+ K D+ QD+ ++
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D I+++ D + E+E + + + F L+
Sbjct: 1902 TRLQKD--ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ----- 1954
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKIAIAKNEEKMLSLSEKDNKL 581
K E +KL SKV L K L+++ +D + + EE++ +L E++
Sbjct: 1955 -KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC 2013
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
L T++ K + E+E Q E +++ E D M+AD +
Sbjct: 2014 ESLEKTLSQTKRQ-----------LSEREQQLVEKSGELLALQK---EADSMRADFSLLR 2059
Query: 642 XXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
K L+ Q L++ E+ ++ S ++ + T E A+ +
Sbjct: 2060 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 2119
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
RL K++ + + E + ++ E + + A++ L+S E +++ T +
Sbjct: 2120 RRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS--EVKDEIRTSLKNLN 2176
Query: 761 GRIAELESDI 770
+ EL +D+
Sbjct: 2177 QFLPELPADL 2186
Score = 46.4 bits (105), Expect = 6e-04
Identities = 51/213 (23%), Positives = 92/213 (43%), Gaps = 8/213 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
++EVS+L++ + Q L K + + + ++E L +EK SLE +V
Sbjct: 1322 ENEVSRLEDIM----QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEE 945
L RT Q ++Q F D V + + + E+E K L+K E
Sbjct: 1378 EELH---RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
LR + L +++ EK ++F ++ L +++ EEL++R +E
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ L+ + K L++ KI E + K N+ VA
Sbjct: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
Score = 39.5 bits (88), Expect = 0.065
Identities = 120/582 (20%), Positives = 221/582 (37%), Gaps = 54/582 (9%)
Query: 216 HIGYDNTLSKLNRSISDSNT--STRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
H D L + IS + T S +++I + ++ E+ K+L E+ +K E
Sbjct: 432 HTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL-EEAIQLKKISEAG 490
Query: 274 EPNMTMDLDEKLGENNEFETKAV-------KVMSEIKRNLNSLSEQLINNESKKSKD--- 323
+ + L +L N+ +A+ K EI + + I +S SKD
Sbjct: 491 KDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
Query: 324 -HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL---EKYTKVQGDLNE 379
H+ K LD E +D I+++ + +EI E+ T+ Q NE
Sbjct: 551 SHMKAQKSGKEQQLDIM--NKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
Query: 380 CTSE-----LKSVNEKLASLNSQLIEKENACNILRIQKE----RIHEIS---SAVTIDIV 427
+ + + E L ++ Q + +N C LR +KE R+ E+ + I +
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKITILFDALITQYELSRTDYEIE 486
EN KE+ E + +++ Q DL A+ + + + E ++ E+E
Sbjct: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAY-EAELEARLNLRDAEANQLKEELE 727
Query: 487 K--EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
K +LE +A EE E LH +L L D+NN
Sbjct: 728 KVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNN 783
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
+K ++ + + + EE + E KL +N + KSL D+
Sbjct: 784 LLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
Query: 605 ITREKETQA-SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
+ E A S+ ER +++ + + +
Sbjct: 844 QKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKR 903
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF-----IEKE 718
Q+ A +Q E + L+ N+K+ E EIQ ++LQ+ +E +++ +EK+
Sbjct: 904 QHEARIQQME---NEIHYLQENLKSME---EIQGLTDLQLQEADEEKERILAQLRELEKK 957
Query: 719 TKLNELTNKYE--ALKRDYDAAVKDLESS-REAVNQLTTQKD 757
KL + ++ + L ++ K + +S + A +LT KD
Sbjct: 958 KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD 999
Score = 39.1 bits (87), Expect = 0.086
Identities = 111/615 (18%), Positives = 247/615 (40%), Gaps = 70/615 (11%)
Query: 68 NEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQ-------IKSLEMENL 120
+E++ ++EK ++ E+ LE Q + +DLL Q + L E L
Sbjct: 454 SELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ +++ + K K+I +LQ D+L + + ++ + ++ + + +
Sbjct: 514 DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS----KDPKHSHMKAQKSGKEQQLDIMNK 569
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
+ LE ++E ++I + + K E + I + L K + S
Sbjct: 570 QYQQLESRLDEILSRIAKET--EEIKDLEEQLTEGQIAANEALKKDLEGV----ISGLQE 623
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ T++ + + +C++L ++ ++ L E+ + +++ EN K +
Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMR------KEL 677
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+E++ L E +N ++++ + Y+ L A L+ + + ++ +
Sbjct: 678 AELESALQEQHE--VNASLQQTQGDLSAYEAELEARLNLR--DAEANQLKEELEKVTRLT 733
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEK---LASLNSQLIEKENACNILRIQKERIH 416
Q++ + + K + L + + EK + L+++L ++ N+L+ Q +
Sbjct: 734 QLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQ 793
Query: 417 EISSAVTIDIVKKEN---ELKEILTKECLKLSKLKIDIPRD-LDQDLPAHKKITILFDAL 472
+ V +V+ E + E+ K L ++ I P D L + L +K F +
Sbjct: 794 NHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK---QFSEI 850
Query: 473 ITQYELSRTDYEIEKEKLRLE-------TGTAKAVXXXXXXXXXXXXXXFD------TLE 519
+ + + R + ++ + KL+ E T + FD ++
Sbjct: 851 LARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQ 910
Query: 520 EAHNEVKSLHEE---------LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
+ NE+ L E LT L + DE ++ L E K+ AK++E+
Sbjct: 911 QMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKE--RILAQLRELEKKKKLEDAKSQEQ 968
Query: 571 MLSLSEKDNKLTELVSTINGLKE-----ENNSLKSLNDVITREKETQASEL---ERSCQV 622
+ L ++ KL + V+T + L + LKSL+ + + + +A EL ER +
Sbjct: 969 VFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRK 1028
Query: 623 IKQNGFELDKMKADI 637
Q +L + +A+I
Sbjct: 1029 AAQAARDLTRAEAEI 1043
Score = 35.1 bits (77), Expect = 1.4
Identities = 46/232 (19%), Positives = 104/232 (44%), Gaps = 20/232 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER---DEQCARLKKEKLSLEQQ 885
++ + K+ + Q+E+ DL+ LD + + ++ ++Q + K+ LE +
Sbjct: 518 QMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESR 577
Query: 886 VSNLKEQIRTQ----QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLM 940
+ + +I + + +E Q +A N + +L V+ Y ++ + +
Sbjct: 578 LDEILSRIAKETEEIKDLEEQLTEGQIAAN-EALKKDLEGVISGLQEYLGTIKGQATQAQ 636
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE-------LKQ 993
+LR +K+ L +T++++ ++ + E RKEL + ++ L+E L+Q
Sbjct: 637 NECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQ 696
Query: 994 RYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN-QKVALEKQIE 1044
+L L R+ + +LKE LE V +L+ ++ AL+ ++E
Sbjct: 697 TQGDLSAYEAELEARLNLRDAEANQLKE---ELEKVTRLTQLEQSALQAELE 745
>AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein.
Length = 1793
Score = 79.4 bits (187), Expect = 7e-14
Identities = 205/1052 (19%), Positives = 425/1052 (40%), Gaps = 108/1052 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
++ S + ++E+L + D+ ++K +LE + + L Q R I +E+L
Sbjct: 813 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDG-NVESLMT 871
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNECL 178
+ EI+ SLK ++E++ TL E + E+D L E + K+ +
Sbjct: 872 ELEIEK---SLKHHEDIVDEIECIEKTLLKRRSE-LREADRLLAEAESELSCTKEKTKNA 927
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTST 237
+K D ++ + ++E+ AQ + NL+++ D L L D
Sbjct: 928 VEKFTDAKRSLLQTESDAEELERRAQ-ETAVNLVKA-----DQQLRSLQADAKDLEQHKI 981
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAV 296
+ +I +++ A ++ DF + E L E + D ++ E NE V
Sbjct: 982 KQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV 1035
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
SE+ Q E +K K + + + AVLD + G ++ L+ +
Sbjct: 1036 LKESEVLL-------QAKRAELEKLKSQVTSQQQEM-AVLDRQLGHKKEELH--LLQGSM 1085
Query: 357 NKYQIDLDEILE----KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + DL E L + T+ + E S L+ ++ + LN Q+ E++ +++ +
Sbjct: 1086 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1145
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
E+ E V + K + ELK IL + L+L ++ + + + D
Sbjct: 1146 EKEEENLQVVLRQMSKHKTELKNIL--DMLQLENHEL-------------QGLKLQHDQR 1190
Query: 473 ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT--LEEAHNEVKSLHE 530
++ EL +T + +EKL LE + D +E E ++L
Sbjct: 1191 VS--ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1248
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+ L K K D L E+ D + +A+ + ++L+ +E+++K+ + S +
Sbjct: 1249 CVECLSKEKED-----------LQEKCDIWEKKLAQTK-RVLAAAEENSKMEQ--SNLEK 1294
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L+ L+ D + R+K + +++ Q +++ ++ ++ ++
Sbjct: 1295 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------ANVQDHL 1348
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
D + Q++ L EQ + +D S + +K E + + + LQ +I+E+
Sbjct: 1349 NLAKQDLLHTTKHQDVLLSEQTRLQ-KDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1407
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREAVNQLTTQK---DLVEGRIAEL 766
+++E L + E+ + + + L E + +LT QK D V ++
Sbjct: 1408 KLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAA 1467
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI- 825
E +RT Q +++ +L K DS + S++
Sbjct: 1468 EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR 1527
Query: 826 ---------SDSEVSQLKERLLSCQQELD-DLKERYKE---LDDECETCAEYLQERDEQC 872
++ +V+ LKE L + +L+ +L E+ +E + E T Q+ E+
Sbjct: 1528 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 1587
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RMSYD 930
RL KE ++ + + LK+Q+ Q+ +ER+ A+ T L S V D R S
Sbjct: 1588 RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT------LKSEVKDEIRTSLK 1641
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ L +E + + ++L+ + +++ + +T + FE K L + + +
Sbjct: 1642 NLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEEK---LNFSQVHIMD 1697
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
R + L E+ + LK + C K+A++ ++ + +L +Q+++L
Sbjct: 1698 EHWRGEALREKLRHREDRLKAQLRHCMS-KQAEVLIKGKRQTEGTLHSLRRQVDALGELV 1756
Query: 1051 VSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
S S ++ S +T+ + Q +K
Sbjct: 1757 TSTSADSASSPSLSQLESSLTEDSQLGQNQEK 1788
Score = 53.2 bits (122), Expect = 5e-06
Identities = 101/547 (18%), Positives = 211/547 (38%), Gaps = 35/547 (6%)
Query: 551 KILSEEI--DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
KI EEI + KI AK+ + LS+K KLTE E L+ ++ R
Sbjct: 980 KIKQEEILKEINKIVAAKDSD-FQCLSKKKEKLTE----------ELQKLQKDIEMAERN 1028
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
++ L+ S +++ EL+K+K+ + +E L +
Sbjct: 1029 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1088
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K +E R E+ K + E+++ ++ L Q E + E++T+L + +
Sbjct: 1089 KADLQEALR-LGETEVTEKCNH-IREVKS-LLEELSFQKGELNVQISERKTQLTLIKQEI 1145
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E + + ++ + + + + D+++ EL+ ++ + V
Sbjct: 1146 EKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQG-LKLQHDQRVSELEKTQVAV 1201
Query: 789 XXXXXXXXXXXTFGDENR-DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + ++ +L + KR I ++ L SC + L
Sbjct: 1202 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-----RMTAESRALQSCVECLSKE 1256
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
KE +L ++C+ + L + A ++ + + L+ +R Q Q
Sbjct: 1257 KE---DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1313
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
++++ D A + R + ++ E+ L + L KQDL +T + +
Sbjct: 1314 LSLHNDIS-AMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1369
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
T+ K+ EDC+ E E +Q+ + L E E L Q+E +RL++ + + E
Sbjct: 1370 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1429
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
KL KV L++Q L + S ++ ++ ++E ++ + K
Sbjct: 1430 --SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 1487
Query: 1088 ITICKKR 1094
++ K++
Sbjct: 1488 LSQTKRQ 1494
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 14/209 (6%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE---QQV 886
+S L+E L + + + + ++L DE ET + L E +++ +L+ + E +++
Sbjct: 92 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 151
Query: 887 SNLKEQIRTQQPVER--QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
+ L+ ++ Q V Q D++ E A L+ + E+EK RL + +
Sbjct: 152 AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 211
Query: 945 -----ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
EL ++Q LKN + K Q + EK +++ E AK K L+D + LKQ+ K+
Sbjct: 212 SALQAELEKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQD---DNNLLKQQLKDFQ 267
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ L + EE R+ E + L++
Sbjct: 268 NHLNHVVDGLVRPEEVAARVDELRRKLKL 296
Score = 48.0 bits (109), Expect = 2e-04
Identities = 150/790 (18%), Positives = 316/790 (40%), Gaps = 59/790 (7%)
Query: 2 LNNDNRIMFXXXXXXXXXXXXXRNQLDGAKSKNDNIIETQSNPIKLQDSG--TITISCKM 59
L +R++ +N ++ ++++T+S+ +L+ T K
Sbjct: 903 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 962
Query: 60 CQSLKE-SSNEINLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQ--TRDLLMSQIKS 114
Q L+ ++ +L+ K+ E L +I + +A + +Q L + + T +L Q K
Sbjct: 963 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ-KD 1021
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+EM +D ++ L +S K EL++ +++ E L + ++L
Sbjct: 1022 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1081
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN 234
+ Q DL++ + E ++ K C + ++L++ L +LN IS+
Sbjct: 1082 QGSMVQAKADLQEALRLGETEVTEK--CNHIREVKSLLEELSF----QKGELNVQISERK 1135
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKN-----HLELHE-PNMTMDLDEKLGEN 288
T K ++ E + + +++ + T +KN LE HE + + D+++ E
Sbjct: 1136 TQLTLIK-QEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL 1194
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ + ++ E++ NL +S+Q E + K ++R K + + AE V
Sbjct: 1195 EKTQVAVLEEKLELE-NLQQISQQQ-KGEIEWQKQLLERDKRE-IERMTAESRALQSCVE 1251
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + D+ E TK E S+++ N + LN + +++E + L
Sbjct: 1252 CLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQE--LDQL 1309
Query: 409 RIQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKK 464
K +H SA+ + +K N L+E L L+ K D+ QD+ ++
Sbjct: 1310 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1369
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D I+++ D + E+E + + + F L+
Sbjct: 1370 TRLQKD--ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ----- 1422
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKIAIAKNEEKMLSLSEKDNKL 581
K E +KL SKV L K L+++ +D + + EE++ +L E++
Sbjct: 1423 -KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC 1481
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
L T++ K + E+E Q E +++ E D M+AD +
Sbjct: 1482 ESLEKTLSQTKRQ-----------LSEREQQLVEKSGELLALQK---EADSMRADFSLLR 1527
Query: 642 XXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
K L+ Q L++ E+ ++ S ++ + T E A+ +
Sbjct: 1528 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 1587
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
RL K++ + + E + ++ E + + A++ L+S E +++ T +
Sbjct: 1588 RRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS--EVKDEIRTSLKNLN 1644
Query: 761 GRIAELESDI 770
+ EL +D+
Sbjct: 1645 QFLPELPADL 1654
Score = 46.4 bits (105), Expect = 6e-04
Identities = 51/213 (23%), Positives = 92/213 (43%), Gaps = 8/213 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
++EVS+L++ + Q L K + + + ++E L +EK SLE +V
Sbjct: 790 ENEVSRLEDIM----QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 845
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEE 945
L RT Q ++Q F D V + + + E+E K L+K E
Sbjct: 846 EELH---RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 902
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
LR + L +++ EK ++F ++ L +++ EEL++R +E
Sbjct: 903 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 962
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ L+ + K L++ KI E + K N+ VA
Sbjct: 963 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 995
Score = 35.9 bits (79), Expect = 0.80
Identities = 92/453 (20%), Positives = 177/453 (39%), Gaps = 37/453 (8%)
Query: 329 KDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE----- 383
K+ L +++ ++ + EIL + I K ++ ++ E+ T+ Q NE +
Sbjct: 34 KEQQLDIMNKQYQQLESRLDEIL--SRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGV 91
Query: 384 LKSVNEKLASLNSQLIEKENACNILRIQKE----RIHEIS---SAVTIDIVKKENELKEI 436
+ + E L ++ Q + +N C LR +KE R+ E+ + I + EN KE+
Sbjct: 92 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 151
Query: 437 LTKECLKLSKLKIDIPRDLDQ-DLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLE 493
E + +++ Q DL A+ + + + E ++ E+EK +LE
Sbjct: 152 AELESALQEQHEVNASLQQTQGDLSAY-EAELEARLNLRDAEANQLKEELEKVTRLTQLE 210
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
+A EE E LH +L L D+NN +K
Sbjct: 211 QSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNNLLKQQLKDF 266
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
++ + + + EE + E KL +N + KSL D+ + E A
Sbjct: 267 QNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILA 326
Query: 614 -SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
S+ ER +++ + + + Q+ A +Q
Sbjct: 327 RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQM 386
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF-----IEKETKLNELTNK 727
E + L+ N+K+ E EIQ ++LQ+ +E +++ +EK+ KL + ++
Sbjct: 387 E---NEIHYLQENLKSME---EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQ 440
Query: 728 YE--ALKRDYDAAVKDLESS-REAVNQLTTQKD 757
+ L ++ K + +S + A +LT KD
Sbjct: 441 EQVFGLDKELKKLKKAVATSDKLATAELTIAKD 473
Score = 32.7 bits (71), Expect = 7.5
Identities = 49/227 (21%), Positives = 101/227 (44%), Gaps = 37/227 (16%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
D + S +K + +Q+LD + ++Y++L+ DE +R+ KE +++
Sbjct: 21 DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL----------DEILSRIAKET----EEI 66
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMKTIEE 945
+L+EQ+ Q +A D L V+ Y ++ + + +
Sbjct: 67 KDLEEQLTEGQIAANEALKKD-----------LEGVISGLQEYLGTIKGQATQAQNECRK 115
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE-------LKQRYKEL 998
LR +K+ L +T++++ ++ + E RKEL + ++ L+E L+Q +L
Sbjct: 116 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDL 175
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN-QKVALEKQIE 1044
L R+ + +LKE LE V +L+ ++ AL+ ++E
Sbjct: 176 SAYEAELEARLNLRDAEANQLKE---ELEKVTRLTQLEQSALQAELE 219
>AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein.
Length = 2325
Score = 79.4 bits (187), Expect = 7e-14
Identities = 205/1052 (19%), Positives = 425/1052 (40%), Gaps = 108/1052 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
++ S + ++E+L + D+ ++K +LE + + L Q R I +E+L
Sbjct: 1345 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDG-NVESLMT 1403
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNECL 178
+ EI+ SLK ++E++ TL E + E+D L E + K+ +
Sbjct: 1404 ELEIEK---SLKHHEDIVDEIECIEKTLLKRRSE-LREADRLLAEAESELSCTKEKTKNA 1459
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTST 237
+K D ++ + ++E+ AQ + NL+++ D L L D
Sbjct: 1460 VEKFTDAKRSLLQTESDAEELERRAQ-ETAVNLVKA-----DQQLRSLQADAKDLEQHKI 1513
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAV 296
+ +I +++ A ++ DF + E L E + D ++ E NE V
Sbjct: 1514 KQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV 1567
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
SE+ Q E +K K + + + AVLD + G ++ L+ +
Sbjct: 1568 LKESEVLL-------QAKRAELEKLKSQVTSQQQEM-AVLDRQLGHKKEELH--LLQGSM 1617
Query: 357 NKYQIDLDEILE----KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + DL E L + T+ + E S L+ ++ + LN Q+ E++ +++ +
Sbjct: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
E+ E V + K + ELK IL + L+L ++ + + + D
Sbjct: 1678 EKEEENLQVVLRQMSKHKTELKNIL--DMLQLENHEL-------------QGLKLQHDQR 1722
Query: 473 ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT--LEEAHNEVKSLHE 530
++ EL +T + +EKL LE + D +E E ++L
Sbjct: 1723 VS--ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 1780
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+ L K K D L E+ D + +A+ + ++L+ +E+++K+ + S +
Sbjct: 1781 CVECLSKEKED-----------LQEKCDIWEKKLAQTK-RVLAAAEENSKMEQ--SNLEK 1826
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L+ L+ D + R+K + +++ Q +++ ++ ++ ++
Sbjct: 1827 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------ANVQDHL 1880
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
D + Q++ L EQ + +D S + +K E + + + LQ +I+E+
Sbjct: 1881 NLAKQDLLHTTKHQDVLLSEQTRLQ-KDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 1939
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREAVNQLTTQK---DLVEGRIAEL 766
+++E L + E+ + + + L E + +LT QK D V ++
Sbjct: 1940 KLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAA 1999
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI- 825
E +RT Q +++ +L K DS + S++
Sbjct: 2000 EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR 2059
Query: 826 ---------SDSEVSQLKERLLSCQQELD-DLKERYKE---LDDECETCAEYLQERDEQC 872
++ +V+ LKE L + +L+ +L E+ +E + E T Q+ E+
Sbjct: 2060 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 2119
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RMSYD 930
RL KE ++ + + LK+Q+ Q+ +ER+ A+ T L S V D R S
Sbjct: 2120 RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT------LKSEVKDEIRTSLK 2173
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ L +E + + ++L+ + +++ + +T + FE K L + + +
Sbjct: 2174 NLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEEK---LNFSQVHIMD 2229
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
R + L E+ + LK + C K+A++ ++ + +L +Q+++L
Sbjct: 2230 EHWRGEALREKLRHREDRLKAQLRHCMS-KQAEVLIKGKRQTEGTLHSLRRQVDALGELV 2288
Query: 1051 VSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
S S ++ S +T+ + Q +K
Sbjct: 2289 TSTSADSASSPSLSQLESSLTEDSQLGQNQEK 2320
Score = 54.4 bits (125), Expect = 2e-06
Identities = 108/561 (19%), Positives = 239/561 (42%), Gaps = 59/561 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
+++ L+ K+ K + EN NL + + EI+ + + + K + + L+ K NK++
Sbjct: 148 KLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISS 207
Query: 584 L--VSTINGLKEENNSLKSLNDVITREKETQASELE-RSCQVI---------KQNGF--- 628
L +S + L++ + + N V+T Q + RS + + +Q F
Sbjct: 208 LQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERF 267
Query: 629 ---ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN 685
E+++++ D+ +E K+ + N +LKE+ + + C L+ +
Sbjct: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSD 327
Query: 686 IKTHEKTAEIQNRMIMR-LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD--- 741
+ T + + + + R QKQ + + +L K E N Y + + D A +
Sbjct: 328 LNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
+ SR N T+ +++ A + ++
Sbjct: 388 IGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPL------------ 435
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE--RYKELDDE-C 858
+ L + K + + +S + D E+ + ++++L +E L+E + K++ +
Sbjct: 436 ---DTQLEDKEKKISAAQTRLSELHD-EIEKAEQQILRATEEFKQLEEAIQLKKISEAGK 491
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ + L R + +L++E L LE Q+ K++I +Q ++ K +A+++ +
Sbjct: 492 DLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQ---KEIKDLQIAIDSLDSKDP 548
Query: 919 LHSVVVDRMS-----YDAEVEKNKRLMKTIEEL--RYKKQ-----DLKNTVTKMQKAMEK 966
HS + + S D ++ ++L ++E+ R K+ DL+ +T+ Q A +
Sbjct: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
Query: 967 YTKKDKE--FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
KKD E ++ L K + + + ++L +E ET + L + E++ +L+ +
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 1025 ALEIVDK-LSNQKVALEKQIE 1044
E + K L+ + AL++Q E
Sbjct: 669 DAENMRKELAELESALQEQHE 689
Score = 53.2 bits (122), Expect = 5e-06
Identities = 101/547 (18%), Positives = 211/547 (38%), Gaps = 35/547 (6%)
Query: 551 KILSEEI--DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
KI EEI + KI AK+ + LS+K KLTE E L+ ++ R
Sbjct: 1512 KIKQEEILKEINKIVAAKDSD-FQCLSKKKEKLTE----------ELQKLQKDIEMAERN 1560
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
++ L+ S +++ EL+K+K+ + +E L +
Sbjct: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K +E R E+ K + E+++ ++ L Q E + E++T+L + +
Sbjct: 1621 KADLQEALR-LGETEVTEKCNH-IREVKS-LLEELSFQKGELNVQISERKTQLTLIKQEI 1677
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E + + ++ + + + + D+++ EL+ ++ + V
Sbjct: 1678 EKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQG-LKLQHDQRVSELEKTQVAV 1733
Query: 789 XXXXXXXXXXXTFGDENR-DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + ++ +L + KR I ++ L SC + L
Sbjct: 1734 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-----RMTAESRALQSCVECLSKE 1788
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
KE +L ++C+ + L + A ++ + + L+ +R Q Q
Sbjct: 1789 KE---DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
++++ D A + R + ++ E+ L + L KQDL +T + +
Sbjct: 1846 LSLHNDIS-AMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
T+ K+ EDC+ E E +Q+ + L E E L Q+E +RL++ + + E
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 1961
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
KL KV L++Q L + S ++ ++ ++E ++ + K
Sbjct: 1962 --SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 2019
Query: 1088 ITICKKR 1094
++ K++
Sbjct: 2020 LSQTKRQ 2026
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 14/209 (6%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE---QQV 886
+S L+E L + + + + ++L DE ET + L E +++ +L+ + E +++
Sbjct: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
Query: 887 SNLKEQIRTQQPVER--QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
+ L+ ++ Q V Q D++ E A L+ + E+EK RL + +
Sbjct: 678 AELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737
Query: 945 -----ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
EL ++Q LKN + K Q + EK +++ E AK K L+D + LKQ+ K+
Sbjct: 738 SALQAELEKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQD---DNNLLKQQLKDFQ 793
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ L + EE R+ E + L++
Sbjct: 794 NHLNHVVDGLVRPEEVAARVDELRRKLKL 822
Score = 48.0 bits (109), Expect = 2e-04
Identities = 150/790 (18%), Positives = 316/790 (40%), Gaps = 59/790 (7%)
Query: 2 LNNDNRIMFXXXXXXXXXXXXXRNQLDGAKSKNDNIIETQSNPIKLQDSG--TITISCKM 59
L +R++ +N ++ ++++T+S+ +L+ T K
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
Query: 60 CQSLKE-SSNEINLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQ--TRDLLMSQIKS 114
Q L+ ++ +L+ K+ E L +I + +A + +Q L + + T +L Q K
Sbjct: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ-KD 1553
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+EM +D ++ L +S K EL++ +++ E L + ++L
Sbjct: 1554 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 1613
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN 234
+ Q DL++ + E ++ K C + ++L++ L +LN IS+
Sbjct: 1614 QGSMVQAKADLQEALRLGETEVTEK--CNHIREVKSLLEELSF----QKGELNVQISERK 1667
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKN-----HLELHE-PNMTMDLDEKLGEN 288
T K ++ E + + +++ + T +KN LE HE + + D+++ E
Sbjct: 1668 TQLTLIK-QEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL 1726
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ + ++ E++ NL +S+Q E + K ++R K + + AE V
Sbjct: 1727 EKTQVAVLEEKLELE-NLQQISQQQ-KGEIEWQKQLLERDKRE-IERMTAESRALQSCVE 1783
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + D+ E TK E S+++ N + LN + +++E + L
Sbjct: 1784 CLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQE--LDQL 1841
Query: 409 RIQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKK 464
K +H SA+ + +K N L+E L L+ K D+ QD+ ++
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D I+++ D + E+E + + + F L+
Sbjct: 1902 TRLQKD--ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ----- 1954
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKIAIAKNEEKMLSLSEKDNKL 581
K E +KL SKV L K L+++ +D + + EE++ +L E++
Sbjct: 1955 -KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC 2013
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
L T++ K + E+E Q E +++ E D M+AD +
Sbjct: 2014 ESLEKTLSQTKRQ-----------LSEREQQLVEKSGELLALQK---EADSMRADFSLLR 2059
Query: 642 XXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
K L+ Q L++ E+ ++ S ++ + T E A+ +
Sbjct: 2060 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 2119
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
RL K++ + + E + ++ E + + A++ L+S E +++ T +
Sbjct: 2120 RRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS--EVKDEIRTSLKNLN 2176
Query: 761 GRIAELESDI 770
+ EL +D+
Sbjct: 2177 QFLPELPADL 2186
Score = 46.4 bits (105), Expect = 6e-04
Identities = 51/213 (23%), Positives = 92/213 (43%), Gaps = 8/213 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
++EVS+L++ + Q L K + + + ++E L +EK SLE +V
Sbjct: 1322 ENEVSRLEDIM----QHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEE 945
L RT Q ++Q F D V + + + E+E K L+K E
Sbjct: 1378 EELH---RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
Query: 946 LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
LR + L +++ EK ++F ++ L +++ EEL++R +E
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ L+ + K L++ KI E + K N+ VA
Sbjct: 1495 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
Score = 39.5 bits (88), Expect = 0.065
Identities = 120/582 (20%), Positives = 221/582 (37%), Gaps = 54/582 (9%)
Query: 216 HIGYDNTLSKLNRSISDSNT--STRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
H D L + IS + T S +++I + ++ E+ K+L E+ +K E
Sbjct: 432 HTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQL-EEAIQLKKISEAG 490
Query: 274 EPNMTMDLDEKLGENNEFETKAV-------KVMSEIKRNLNSLSEQLINNESKKSKD--- 323
+ + L +L N+ +A+ K EI + + I +S SKD
Sbjct: 491 KDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKH 550
Query: 324 -HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL---EKYTKVQGDLNE 379
H+ K LD E +D I+++ + +EI E+ T+ Q NE
Sbjct: 551 SHMKAQKSGKEQQLDIM--NKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
Query: 380 CTSE-----LKSVNEKLASLNSQLIEKENACNILRIQKE----RIHEIS---SAVTIDIV 427
+ + + E L ++ Q + +N C LR +KE R+ E+ + I +
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKITILFDALITQYELSRTDYEIE 486
EN KE+ E + +++ Q DL A+ + + + E ++ E+E
Sbjct: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAY-EAELEARLNLRDAEANQLKEELE 727
Query: 487 K--EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
K +LE +A EE E LH +L L D+NN
Sbjct: 728 KVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQ----DDNN 783
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
+K ++ + + + EE + E KL +N + KSL D+
Sbjct: 784 LLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843
Query: 605 ITREKETQA-SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
+ E A S+ ER +++ + + +
Sbjct: 844 QKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKR 903
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLF-----IEKE 718
Q+ A +Q E + L+ N+K+ E EIQ ++LQ+ +E +++ +EK+
Sbjct: 904 QHEARIQQME---NEIHYLQENLKSME---EIQGLTDLQLQEADEEKERILAQLRELEKK 957
Query: 719 TKLNELTNKYE--ALKRDYDAAVKDLESS-REAVNQLTTQKD 757
KL + ++ + L ++ K + +S + A +LT KD
Sbjct: 958 KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKD 999
Score = 39.1 bits (87), Expect = 0.086
Identities = 111/615 (18%), Positives = 247/615 (40%), Gaps = 70/615 (11%)
Query: 68 NEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQ-------IKSLEMENL 120
+E++ ++EK ++ E+ LE Q + +DLL Q + L E L
Sbjct: 454 SELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ +++ + K K+I +LQ D+L + + ++ + ++ + + +
Sbjct: 514 DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS----KDPKHSHMKAQKSGKEQQLDIMNK 569
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
+ LE ++E ++I + + K E + I + L K + S
Sbjct: 570 QYQQLESRLDEILSRIAKET--EEIKDLEEQLTEGQIAANEALKKDLEGV----ISGLQE 623
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ T++ + + +C++L ++ ++ L E+ + +++ EN K +
Sbjct: 624 YLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMR------KEL 677
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+E++ L E +N ++++ + Y+ L A L+ + + ++ +
Sbjct: 678 AELESALQEQHE--VNASLQQTQGDLSAYEAELEARLNLR--DAEANQLKEELEKVTRLT 733
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEK---LASLNSQLIEKENACNILRIQKERIH 416
Q++ + + K + L + + EK + L+++L ++ N+L+ Q +
Sbjct: 734 QLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQ 793
Query: 417 EISSAVTIDIVKKEN---ELKEILTKECLKLSKLKIDIPRD-LDQDLPAHKKITILFDAL 472
+ V +V+ E + E+ K L ++ I P D L + L +K F +
Sbjct: 794 NHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK---QFSEI 850
Query: 473 ITQYELSRTDYEIEKEKLRLE-------TGTAKAVXXXXXXXXXXXXXXFD------TLE 519
+ + + R + ++ + KL+ E T + FD ++
Sbjct: 851 LARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQ 910
Query: 520 EAHNEVKSLHEE---------LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
+ NE+ L E LT L + DE ++ L E K+ AK++E+
Sbjct: 911 QMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKE--RILAQLRELEKKKKLEDAKSQEQ 968
Query: 571 MLSLSEKDNKLTELVSTINGLKE-----ENNSLKSLNDVITREKETQASEL---ERSCQV 622
+ L ++ KL + V+T + L + LKSL+ + + + +A EL ER +
Sbjct: 969 VFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRK 1028
Query: 623 IKQNGFELDKMKADI 637
Q +L + +A+I
Sbjct: 1029 AAQAARDLTRAEAEI 1043
Score = 35.1 bits (77), Expect = 1.4
Identities = 46/232 (19%), Positives = 104/232 (44%), Gaps = 20/232 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER---DEQCARLKKEKLSLEQQ 885
++ + K+ + Q+E+ DL+ LD + + ++ ++Q + K+ LE +
Sbjct: 518 QMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESR 577
Query: 886 VSNLKEQIRTQ----QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLM 940
+ + +I + + +E Q +A N + +L V+ Y ++ + +
Sbjct: 578 LDEILSRIAKETEEIKDLEEQLTEGQIAAN-EALKKDLEGVISGLQEYLGTIKGQATQAQ 636
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE-------LKQ 993
+LR +K+ L +T++++ ++ + E RKEL + ++ L+E L+Q
Sbjct: 637 NECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQ 696
Query: 994 RYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN-QKVALEKQIE 1044
+L L R+ + +LKE LE V +L+ ++ AL+ ++E
Sbjct: 697 TQGDLSAYEAELEARLNLRDAEANQLKE---ELEKVTRLTQLEQSALQAELE 745
>AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein.
Length = 1088
Score = 79.4 bits (187), Expect = 7e-14
Identities = 99/506 (19%), Positives = 206/506 (40%), Gaps = 25/506 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+N ++ ++K ++ ++ + LKE K + + L
Sbjct: 435 FMKN--KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL 492
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ + E + M+ + KQIQ+ + + ++++L + + +R + K +
Sbjct: 493 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 552
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E+ +E + Q ++ R+ L++D TA
Sbjct: 553 ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 612
Query: 803 DENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
E ++ +N K D K +S++ ++S+ + LL ++ L + D +T
Sbjct: 613 REKQEEIDNYKKDLKDLKEKVSLL-QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 671
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
L+++ E+C +++ + ++ + R + + + + + +D ++
Sbjct: 672 EIALEQKKEECLKMESQL----KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 727
Query: 922 VVVDRM---SYDAEVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK 977
VDR+ + E EKN + K E E + K Q+ K K ++ +EK EA+
Sbjct: 728 AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEAR 787
Query: 978 RKE--LEDCKAELEE-LKQ---RYKELDEECETCAEYLKQRE-----EQCKRLKEAKIAL 1026
R+E L D +L++ L++ R +EL+E + +RE E+ R K
Sbjct: 788 RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVE 847
Query: 1027 EIVDKLSNQKVALEKQIESLSNTPVS 1052
E++ + K LE LS+T S
Sbjct: 848 ELLMAMEKVKQELESMKAKLSSTQQS 873
Score = 60.1 bits (139), Expect = 4e-08
Identities = 137/667 (20%), Positives = 275/667 (41%), Gaps = 58/667 (8%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSL---KESSNEINLKLEKLSGELFDIKEQKSALEGK 94
IETQ + +D +I +M QS +++ E + + +L+ + +S LE K
Sbjct: 295 IETQKQTLNARDE-SIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
Query: 95 Y-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNL 153
+N +L + + S + + L E+K+ + + + + +L+EE L +
Sbjct: 354 EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD--SKISSMERGLRDLEEEIQMLKSN 411
Query: 154 IMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ 213
+ E + K+++ + +++ + K +++ ++ + ++ + Q KL E L
Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL----LALQTKL-ETLTN 466
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
+ SK + + + + + + LQ+E+DA R +E ++ N
Sbjct: 467 QF------SDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK----ETMLNKKTKQ 516
Query: 274 EPNMTMDLDEKLGENNEF----ETKAVKVMSEIKRNLNSLSEQLINNESKKS--KDHIDR 327
+M + + GE ++ + K KV + +++ + +L EQL + E + S K+ +
Sbjct: 517 IQDMAEEKGTQAGEIHDLKDMLDVKERKV-NVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
Query: 328 YK------DSLLAVLD---AEFGTT------SLDVFEILMDNIINKYQIDLDEILEKYTK 372
+ D+ L L+ AE T D E I+ Y+ DL ++ EK +
Sbjct: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
+QGDL+E + L + E +SL S ++K++ L I E+ E + + K
Sbjct: 636 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA 695
Query: 433 LKEILTKECL--KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKL 490
E + ++ L+ +I R D+ A ++ L + ++ + E + D + + +L
Sbjct: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE-ILKEVENEKNDKDKKIAEL 754
Query: 491 -RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS--KVDENNANL 547
R K V LEEA +L++ +L S K D+ L
Sbjct: 755 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
Query: 548 NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK---SLNDV 604
S +I A + + EE + +EK ++ EL+ + +K+E S+K S
Sbjct: 815 EEALRESVQITAEREMVLAQEESARTNAEK--QVEELLMAMEKVKQELESMKAKLSSTQQ 872
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
EKET + L +++ E+ +MK + L+ K E+
Sbjct: 873 SLAEKETHLTNLRAE---RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 929
Query: 665 NLALKEQ 671
ALK +
Sbjct: 930 VAALKRE 936
Score = 58.0 bits (134), Expect = 2e-07
Identities = 148/743 (19%), Positives = 295/743 (39%), Gaps = 87/743 (11%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF----DIKEQKSALEG 93
I+ N + QDS + T + + +E+ ++ + E+ + ELF ++E + +E
Sbjct: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET 297
Query: 94 KYQNLILETQT-RDLL-MSQIKSLEMENLTKDKE-----------IKNLTDSLKTKSKKI 140
+ Q L ++ + LL M Q K L + +D E + +L L+ K K+
Sbjct: 298 QKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN 357
Query: 141 NELQEE--------NDTLSNLIMENVTESD------------NLNKEVDDLKKNNECLTQ 180
+ L+EE D+ ++ V E +L +E+ LK N T+
Sbjct: 358 SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
Query: 181 KCIDLEKL--VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ + K V S +K KN Q K + + + + L L SDS
Sbjct: 418 EREEEMKQMEVYRSHSKF-MKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK---- 472
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT------MDLDEKLGENNEFE 292
I L+ L A + L + +++ LE E + D+ E+ G E
Sbjct: 473 -QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKG-TQAGE 530
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
+K M ++K ++ ++ I N ++ +D + V + TT+ D +
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590
Query: 353 DNIINKYQIDLDEILEKYTK----VQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + ++ + E+ + Q +++ +LK + EK++ L L EKE ++L
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE--ASLL 648
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
++ E +S++ +KK++ LK + + E K LK++ + + +
Sbjct: 649 DLK-----EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 703
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
I E T Y+ E K + E + LE +VK
Sbjct: 704 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE---RQVKD 760
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
++++ L + E + +++ D L +++ SL +KD+++ EL
Sbjct: 761 QNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN---DSSQQLQDSLRKKDDRIEELEEA 817
Query: 588 IN---GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXX 644
+ + E + + + E Q EL + + +KQ EL+ MKA +
Sbjct: 818 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ---ELESMKAKLSSTQQSL 874
Query: 645 XXXXXXXXXXXDEAKSLLEQNLALKEQC-----EEKTRDCSRLEINI---KTHEKTAEI- 695
E + LE+ L +K++ EK + + LE++ KT E+ A +
Sbjct: 875 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK 934
Query: 696 --QNRMIMRLQKQIQEDDKLFIE 716
++R++ +L++Q Q KL +
Sbjct: 935 REKDRLVQQLKQQTQNRMKLMAD 957
Score = 44.8 bits (101), Expect = 0.002
Identities = 61/284 (21%), Positives = 122/284 (42%), Gaps = 14/284 (4%)
Query: 57 CKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR-DLLMSQIKSL 115
C +S + ++E L+ + S E+ D + +Y++ + Q D L+ +K +
Sbjct: 682 CLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 740
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKEVDDL 171
E E KDK+I L +K ++KK+ L Q E + ++ E DNLN L
Sbjct: 741 ENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 800
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKN-ICAQCKLK----ENLIQSLHIGYDNTLSKL 226
+ + + +LE+ + ES + + AQ + E ++ L + + +L
Sbjct: 801 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 860
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
S+ +ST+ + + ++ L R + ++ E+ +K L + D + L
Sbjct: 861 E-SMKAKLSSTQQS-LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDANIALL 917
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E + + K + ++ +KR + L +QL + K D Y+D
Sbjct: 918 ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 961
>AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein.
Length = 1978
Score = 78.2 bits (184), Expect = 2e-13
Identities = 198/1058 (18%), Positives = 431/1058 (40%), Gaps = 58/1058 (5%)
Query: 35 DNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGK 94
+N+++ + + D I K Q L+ E K+E+L ++ DI ++ S+ E
Sbjct: 269 ENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEND 328
Query: 95 YQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE---ENDTLS 151
L E + ++ QI E ENL E L S +S + E + ++ ++
Sbjct: 329 RDILRREQEQLNVEKRQIME-ECENLKL--ECSKLQPSAVKQSDTMTEKERILAQSGSVE 385
Query: 152 NL--IMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK--L 207
+ + + +++++N + L ++N L + + L+ + E + K++ +Q K L
Sbjct: 386 EVFRLRQALSDAENEIMRLSSLNQDNS-LAEDNLKLKMRIEVLEKE---KSLLSQEKEEL 441
Query: 208 KENLIQSLHIGYDNTLSKLNRSIS-DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSI 266
+ +L++ L+ Y+ S R IS DS + + EL+ + + L + +
Sbjct: 442 QMSLLK-LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
Query: 267 KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID 326
+ +M + + + NE ++ ++S++K++LN +++ E K D
Sbjct: 501 DRQNQEATKHMILIKAQLSKQQNEGDS----IISKLKQDLNDEKKRVHQLEDDKM-DITK 555
Query: 327 RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS 386
+ ++ +E L + + +++ + L++ E +Q + E ++
Sbjct: 556 ELDVQFVLLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQ 615
Query: 387 VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSK 446
E+L+ + ++L++ N + + + E + V ++ + +EL+++ E LK K
Sbjct: 616 NEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVR-NLKQNLSELEQL--NENLK--K 670
Query: 447 LKIDIPRDLDQDLPAHKKITI-LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXX 505
+ D+ + ++ + A + + L + L +LS I E L++E G +A
Sbjct: 671 VAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV-ETLKMEKGEIEAELCWAK 729
Query: 506 XXXXXXXXXFD-TLEEAHNEVKSLHEELTKLYKSKVDENNANLNL-IKILSEEIDALKIA 563
++ T+EE N ++L+ +L + + N ++ I L + I+ +
Sbjct: 730 KRLLEEANKYEKTIEELSN-ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTD 788
Query: 564 IAKNEEKMLSLSEKDNKLTELVST----INGLKEENNSLKSLNDVITREKETQASELERS 619
+ ++ + S E+ +LT+L++ I LKE ++ L+ D ++ + +E+ R
Sbjct: 789 HKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQA--LRKNEILR- 845
Query: 620 CQVIKQNGFELDKMKADI--LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR 677
Q I++ L MK + L + K+L + L + +
Sbjct: 846 -QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTL-DSVTELASEVSQLNT 903
Query: 678 DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDA 737
LE IK H+K E QN+ M+L + +QE K E + ++ + L + D
Sbjct: 904 IKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE 963
Query: 738 AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXX 797
+K L+ + + Q+ TQ I SDI ++T
Sbjct: 964 EIKSLQ---KTIEQIKTQLHEERQDIQTDNSDI-FQETKVQSLNIENGSEKHDLSKAETE 1019
Query: 798 XXTFGDENRDLGENPKLDD---SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
G + R+L E L++ S + I +S EV +L + + E+ L R
Sbjct: 1020 RLVKGIKEREL-EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISST 1078
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA-DVAVNTD 913
+ YLQ++ + A +++ ++ + + ++T+ A + A+
Sbjct: 1079 SHTQDVV--YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKL 1136
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
+D S + D E + L + I E + L + ++ + ++
Sbjct: 1137 QDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEA 1196
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---IVD 1030
+ E+ E ++LKQ+ K+++E + ++ + + +L+E L+ +VD
Sbjct: 1197 GGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVD 1256
Query: 1031 KLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ 1068
+N K L+ L + N T G + Q Q
Sbjct: 1257 SDNNSK--LQVDYTGLIQSYEQNETKLKNFGQELAQVQ 1292
Score = 68.9 bits (161), Expect = 9e-11
Identities = 194/1088 (17%), Positives = 438/1088 (40%), Gaps = 93/1088 (8%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R+QL+ + N+ + ++ ++ I ++C + K E N K EK EL +
Sbjct: 690 RHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEAN-KYEKTIEELSN 748
Query: 84 IKE-QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ SAL+ ++++LI Q +D+ ++++K + T KE K++ S + K++ +
Sbjct: 749 ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 808
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L + + + E S L +E+D K ++ L + I L + + E + +G
Sbjct: 809 LINKKEIFIEKLKER---SSKLQEELD---KYSQALRKNEI-LRQTIEEKDRSLGSMKE- 860
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--STRYNKICTLQSELDAGREDCKELC 260
L+E L + L T + DS T ++ +++ T++ L+ + +++
Sbjct: 861 ENNHLQEEL-ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKII 919
Query: 261 EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQL 313
ED K L ++DE ++ + ++ E +++ + + QL
Sbjct: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII-------------NKYQ 360
D+ D ++++ + L+ E G+ D+ + + ++ N+
Sbjct: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN 1039
Query: 361 IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEIS 419
I L + +++ +K ++ + T ++ + ++ +L++++ + +++ +Q++ + + +
Sbjct: 1040 ISLTKQIDQLSK--DEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME 1097
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL------I 473
++ ++ L E K+ + L + +KK++ F++
Sbjct: 1098 REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRE 1157
Query: 474 TQYELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
T LSR + +IE + L + T AV + EE E L ++
Sbjct: 1158 TIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQ 1217
Query: 532 LTKL--YKSKVDENNANLNLIKI-LSEEIDALKIAI---AKNEEKML--------SLSEK 577
+ K+ +K +V N+ L EE+ L+ + + N K+ S +
Sbjct: 1218 VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQN 1277
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
+ KL + ++ L + D++ + + + +L + + Q+ L K+++
Sbjct: 1278 ETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
L + KSL E++ ++ E R + + K E +
Sbjct: 1338 L-----SESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1392
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
I +L+++ KL EK+ + +++ + ++ V + E R+AV L +
Sbjct: 1393 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL 1452
Query: 758 LVEGRIAELESD----IRTEQ-TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
++E I +L+ + + T + T + + L
Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512
Query: 813 KLDDSPKRSISVISD--SEVSQLKERLLSCQQELDD----LKERYKE---LDDECETCAE 863
L + + ++ + V ++E+ + QQE D LK++ E L +E + +
Sbjct: 1513 LLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD 1572
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+++ RL+ LE + S +E + + +R+AK +E + S
Sbjct: 1573 KEFRSNQELERLRNH--LLESEDSYTREALAAE---DREAKLRKKVTVLEEKLVS-SSNA 1626
Query: 924 VDRMSYDA--EVEKNKRLMKTIEELRYK---KQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
++ S+ A +VE + + + + R + + L TV + + ++ + F+ +
Sbjct: 1627 MENASHQASVQVESLQEQLNVVSKQRDETALRFCLSGTVKQYRLSLANLQMVLEHFQQEE 1686
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
K + AELE+ KQ E + E + +E C L EA AL+ +L+ Q
Sbjct: 1687 KAM--YSAELEKQKQLIAEWKKNAENLEGKVISLQE-C--LDEANAALDSASRLTEQLDV 1741
Query: 1039 LEKQIESL 1046
E+QIE L
Sbjct: 1742 KEEQIEEL 1749
Score = 38.3 bits (85), Expect = 0.15
Identities = 45/220 (20%), Positives = 96/220 (43%), Gaps = 12/220 (5%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+EV +L+++ QEL+ L+ E +D A ++R+ A+L+K+ LE+++
Sbjct: 1565 NEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE---AKLRKKVTVLEEKL- 1620
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEEL 946
+ + +E + A V V + ++ N+ S D + + K+ ++ L
Sbjct: 1621 -----VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALRFCLSGTVKQYRLSLANL 1675
Query: 947 RYKKQDLKNTVTKMQKA-MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
+ + + M A +EK + E++ + LE L+E +
Sbjct: 1676 QMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRL 1735
Query: 1006 AEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALEKQIE 1044
E L +EEQ + LK + ++ E++D + + ++L E
Sbjct: 1736 TEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1775
Score = 36.7 bits (81), Expect = 0.46
Identities = 53/248 (21%), Positives = 112/248 (45%), Gaps = 21/248 (8%)
Query: 806 RDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
++L +N + D + +SV+ ++ +L E ++EL D +ER +EL++ +
Sbjct: 219 KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSG 278
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
+ E D K ++ QV +++ T++ + + K D +N A ++
Sbjct: 279 VIETDLS----KIYEMQKTIQVLQIEKVESTKKMEQLEDKIKD--INKKLSSAENDRDIL 332
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
R VEK +++M+ E L+ + L+ + K M T+K++ A+ +E
Sbjct: 333 RREQEQLNVEK-RQIMEECENLKLECSKLQPSAVKQSDTM---TEKER-ILAQSGSVE-- 385
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK----LSNQKVALE 1040
E+ L+Q + + E + L Q + + K+ +E+++K LS +K L+
Sbjct: 386 --EVFRLRQALSDAENEIMRLSS-LNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442
Query: 1041 KQIESLSN 1048
+ L+N
Sbjct: 443 MSLLKLNN 450
>BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein.
Length = 1843
Score = 77.8 bits (183), Expect = 2e-13
Identities = 228/1113 (20%), Positives = 445/1113 (39%), Gaps = 92/1113 (8%)
Query: 41 QSNPIKLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEG-KYQ 96
Q N L D+ + + +L+E + +++ ++ + L DI+ K+ +E K
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 97 N-LILETQT--RDLL------MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEEN 147
N ++LET+T D L ++ LE ENL ++ ++ KKI EL EEN
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 148 DTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKL 207
TL +++ ES +L E++ + + +E L VNE + K L
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 208 KENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGRE---DCKELCEDF 263
+ ++ L D+ ++ + + R +K + L++E+ ++ +C+ L +D
Sbjct: 473 TKT-VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 264 TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKD 323
K LE T+ E L EN+E + +K++ + +LN L ++
Sbjct: 532 MKEKAQLE-----KTI---ETLRENSE---RQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 324 HI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNECT 381
+ D K++ +L TS + +I + K +++ E E+ +++ +L+
Sbjct: 581 RVKDIEKEN--KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
E + + +K+ +L EK A + ER + T+D K E L KE
Sbjct: 639 KENELLQKKITNLKITC-EKIEALEQENSELERENR-KLKKTLDSFKNLTFQLESLEKEN 696
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLETGTAKA 499
+L + +++ R+++ A K+ L + EL +++K E L+ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQL---QLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDA 559
+ TLE ++ +++ L EL L + + NL +KI S+ ++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLEQ 812
Query: 560 LKIAIAKNEEKMLSLS------EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
L+ E++ L EK+NK + I E N++K N + +E +T +
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN--LEKENKTLS 870
Query: 614 SEL---ERSCQVIKQ---NGFELDK-----MKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
E+ + SC +K+ EL K +K + + D K
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 663 E-QNLAL-KEQC--EEKTRDCSR---LEINIK-THEKTAEIQNRMIMRLQKQIQEDDKLF 714
E + + L KE+ +E++ D SR LE ++ T +K+ EI+ I L+ +++E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
Query: 715 IEKETKLNELTNKYEALKRDYD--------AAVKDLESSREAVNQLTTQKDL-VEGRIAE 765
+ +L + YEALK+ D + ++ E +Q TT++ L V+ R+ E
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI 825
+E + T Q + L E + + V
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV- 1109
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK--EKLSL- 882
E S L + S + L + L++E E+ + ++ L K EKL L
Sbjct: 1110 ---ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1166
Query: 883 -EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN---LHSVVVDRMSYDAEVEKNKR 938
E+Q S + I ++ K +V ED N ++ + +VE+ K
Sbjct: 1167 HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1226
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L++ + + K + + Y++ KE E + + ++ K+ L K L
Sbjct: 1227 LLEN-KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 999 DEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVALEKQIES--LSNTPVSNST 1055
+ E E +Q + +L + ++ ++ L + L QI++ L N +
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLI 1088
M + Q Q I + + ++ +K+ K++
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIM 1378
Score = 62.5 bits (145), Expect = 8e-09
Identities = 150/752 (19%), Positives = 315/752 (41%), Gaps = 76/752 (10%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
I + + +L+E E+ + +L + ELK + ++ N L+ + + R + + +
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRDELDAL 315
Query: 416 HEISSAVTIDIVKKE-NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
E AV +D ++ E + KE L ++ K +++ ++ +Q L K T+L D L
Sbjct: 316 RE--KAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK--TMLEDQLEG 369
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
S +E+EKE L+L+ + + + +S+ E L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 535 LYKSKVDENNANLNLI--KILSEEIDALKIA-IAKNEEKMLSLSEKDNKLTELVSTINGL 591
++ + + L+ K L E++ L + + K E + SL++ +L V ++ G
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+ ++ N ++++ E +E+ + Q + QN L K D++
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSL-QNCQNLSK---DLMKEKAQLEKTIETL 545
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+ +LEQ Q R R +I+ + K E +N++ L + I+E
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKI---LHESIKETS 600
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI- 770
+ E + ++ + E K + A ++LE+ ++ L + +L++ +I L+
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERA-EELENE---LHHLEKENELLQKKITNLKITCE 656
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
+ E TF E+ + EN +LD+ + E+
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-ENSQLDEE---------NLEL 706
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLK 890
+ E L ++ L+ KEL+ E E + L+ + + K E+L + Q +++
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL--KASFKKTERLEVSYQGLDIE 764
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKK 950
Q R Q+ +E K + + L + ++ + +E+ K K +E+L +
Sbjct: 765 NQ-RLQKTLENSNK------KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
+ L+ ++++K ++ K++K ++ E++D LEE + L++E +T ++ +
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLR-QQAEIKD--TTLEENNVKIGNLEKENKTLSKEIG 874
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI 1070
+E C RLKE LEK+ + L V +T+ + T +V ++
Sbjct: 875 IYKESCVRLKE-----------------LEKENKEL----VKRATIDIKT---LVTLRE- 909
Query: 1071 TDVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D++ E K ++MN L + + K G N+E
Sbjct: 910 -DLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 36.3 bits (80), Expect = 0.61
Identities = 17/47 (36%), Positives = 28/47 (59%)
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL 1026
EL D KA++ L+Q +E E+ C + L+Q E + KRL++ + L
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 819 KRSISVISDSEVSQLKERLLSCQ---QELDDLKERYKELD-DECETCAEYLQE---RDEQ 871
K S EV +L LL C Q+ ++ ER + LD D A ++QE E
Sbjct: 110 KNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN 169
Query: 872 CARLKKEK---LSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
L+ + +S E LK + ++ ++ + + ++ + E+ LH +
Sbjct: 170 VFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHA 227
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S A+ MK E ++ +L + K+++ + E E K ++L DCK E
Sbjct: 228 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQ-------ELEEKTEQLLDCKQE 280
Query: 988 LEELKQRYKELDEE 1001
LE+++ K L +E
Sbjct: 281 LEQMEIELKRLQQE 294
>BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 77.8 bits (183), Expect = 2e-13
Identities = 236/1119 (21%), Positives = 449/1119 (40%), Gaps = 125/1119 (11%)
Query: 32 SKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSAL 91
S+ + ET S + + SGT + ++LKE I L + E ++ + S +
Sbjct: 331 SRTGLLTETSSRYAR-KISGTTALQ----EALKEKQQHIEQLLAERDLERAEVAKATSHV 385
Query: 92 EGKYQNLILETQTRD--LLMSQIKSLEMENLTK--DKEIKNLTDSLKTKSKKINELQ--- 144
Q L L D +L + K ++ + + D+E L + L+ + +K+ +LQ
Sbjct: 386 GEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Query: 145 -EENDTLSNLIMENVTESDNLNKEVD----DLKKNNECLTQKCIDLEKLVNESENK---- 195
EE+ T +L ++ D N + +K+ + L + +KL E E+
Sbjct: 446 EEESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVAT 505
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS-TRYNKICTLQSELDAGRE 254
+ K+ + + K+ ++ + + N+ D + S + +I +LQ +L+ R
Sbjct: 506 VSEKSRIMELE-KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 564
Query: 255 DCKELCEDFTSIKNHLELHEPNMTMDLD------EKLGENNEFETKAVKVMSEIKRNLNS 308
D + + TS+K H E ++ EKL + NE ++ ++ ++ +
Sbjct: 565 DHQR---EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 621
Query: 309 LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
L + + + ++ K S L GT + + E+ I K ++D +E
Sbjct: 622 LWKSKLETAIASHQQAMEELKVSFSKGL----GTETAEFAELKTQ--IEKMRLDYQHEIE 675
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
Q +E + K + A L + EKEN+ +R + ++ + D +
Sbjct: 676 NLQNQQD--SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 733
Query: 429 K--ENELK----EILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
K E E+K E+L +C + +K+ ID + L A ++ + DAL + S
Sbjct: 734 KLQEAEIKVKELEVLQAKCNEQTKV-ID---NFTSQLKATEEKLLDLDAL--RKASSEGK 787
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
E++K + +LE + T E E+K LT L E
Sbjct: 788 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK-----LTNL-----QE 837
Query: 543 NNANLNLIK-ILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNS 597
N + ++ +K L +E+ LK A+ E+ +S + E NKL + N L +
Sbjct: 838 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 897
Query: 598 LK-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
L+ +L D+ + +E ER Q+IK +K++ DI D
Sbjct: 898 LRENLADMEAKFREKD----EREEQLIKAK----EKLENDIAEIMKMSGDNPSQLTKMND 949
Query: 657 EAKSLLEQNLA-LKEQCEEKTRDCSRLEINIKTHEKTAE-IQNRMIMRLQKQIQEDDKLF 714
E + L E+++ L+ + + + S L+ +I+ AE Q + +++ +E ++
Sbjct: 950 ELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 1008
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
+ E K+ N+ + LK Y+ A + ++ E + Q QK L++ + R E
Sbjct: 1009 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ-NLQKTLLDTE--DKLKGAREEN 1065
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
+ + T D + + + K +++ ++ S + Q
Sbjct: 1066 SGLLQELEELRKQAEKAKAAQ----TAEDAMQIMEQMTK-----EKTETLASLEDTKQTN 1116
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
+L Q ELD LKE + +E E L +++ +KE +L+Q + +Q+
Sbjct: 1117 AKL---QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLS 1173
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY--DAEVEKNKRLMKTIEELRYKKQD 952
Q E K A+ + D H + + S + +E KR K I++ +K
Sbjct: 1174 ALQ--EENVKLAE-ELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1230
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQR 1012
L+ +++ + A+ T+KD E E R E+ + E K + +
Sbjct: 1231 LQKSIS-ITSAL--LTEKDAELEKLRNEVTVLRGENASAKSLHSVV-------------- 1273
Query: 1013 EEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESLS-NTPVSNSTMYVATGSAI-VQNQQ 1069
+ L+ K+ LE+ V L Q ++Q+ S S NT A S I N
Sbjct: 1274 ----QTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSV 1329
Query: 1070 ITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPSD 1108
I D+ ++NQ L KM ++++ G G + N D D
Sbjct: 1330 IVDLQRKNQDL-KMKVEMMSEAALNG-NGDDLNNYDSDD 1366
Score = 65.3 bits (152), Expect = 1e-09
Identities = 155/769 (20%), Positives = 298/769 (38%), Gaps = 66/769 (8%)
Query: 28 DGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQ 87
+ KSK ++ + S+ I L S T Q+++E + L + E ++K Q
Sbjct: 603 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 662
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD-----KEIKNLTDSLKTKSKKINE 142
+ YQ+ I Q + + EME L KE +N +++++K K +
Sbjct: 663 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 722
Query: 143 --LQEENDTLSNLIMENV---------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVN- 190
L E DTL+ L + + + K +D+ + +K +DL+ L
Sbjct: 723 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 782
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
SE K K + Q + E I+ L I + N S +++ TR EL
Sbjct: 783 SSEGKSEMKKLRQQLEAAEKQIKHLEI-------EKNAESSKASSITR---------ELQ 826
Query: 251 AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
L E+ + + E E + + L EK E +E +AV V ++ +N L
Sbjct: 827 GRELKLTNLQENLSEVSQVKETLEKELQI-LKEKFAEASE---EAVSVQRSMQETVNKLH 882
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
++ + +++ +++ LA ++A+F D E + K + D+ EI++
Sbjct: 883 QK--EEQFNMLSSDLEKLREN-LADMEAKF--REKDEREEQLIKAKEKLENDIAEIMKMS 937
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L + EL+ + L +L + + L+ E + + + KK
Sbjct: 938 GDNPSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 997
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPA-HKKIT----ILFDALITQYELSRTDYEI 485
E K+ L ++ L K K++ + Q+L A +++ T + ++ + + D E
Sbjct: 998 EEEKKELERKLSDLEK-KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE- 1055
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+K K E + T E+A ++ + +E T+ S D
Sbjct: 1056 DKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1115
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNSLKSL 601
N L E+D LK KN E++ L+ ++ K+ E I LK+
Sbjct: 1116 NAK----LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1171
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ E A EL RS + + +L++ ++ + DE K+
Sbjct: 1172 LSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1230
Query: 662 LEQNLALKEQ-CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
L++++++ EK + +L E+ + E + ++ Q E DK+ +E +
Sbjct: 1231 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV----QTLESDKVKLELK 1286
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
K EL K + + D ++ + Q +Q D + I +L+
Sbjct: 1287 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQ-ESQIDFLNSVIVDLQ 1334
Score = 64.1 bits (149), Expect = 3e-09
Identities = 124/613 (20%), Positives = 266/613 (43%), Gaps = 59/613 (9%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R++LD K+++ +++E + KLQ++ I K + L+ NE ++ + +L
Sbjct: 714 RSKLD--KAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFTSQLKA 768
Query: 84 IKEQ--------KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
+E+ K++ EGK + L Q + QIK LE+E + + ++T L+
Sbjct: 769 TEEKLLDLDALRKASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAESSKASSITRELQG 827
Query: 136 KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ K+ LQE +S + + L KE+ LK+ +++ + +++ + E+ NK
Sbjct: 828 RELKLTNLQENLSEVSQV-------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 880
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ K + + N++ S L KL +++D ++ + + +L +E
Sbjct: 881 LHQK------EEQFNMLSS-------DLEKLRENLAD--MEAKFREKDEREEQLIKAKEK 925
Query: 256 CKELCEDFTSIK--NHLELHEPNMTMDLDEKLGENNEFE-TKAVKVMSEIKRNLNSLSEQ 312
+ + + N +L + N + L E+ E + + TKA + S +++++ ++ +
Sbjct: 926 LENDIAEIMKMSGDNPSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 985
Query: 313 LINNESKKSKDHIDRYK--DSLLAVLDAEFGTTSLDVFEI--LMDNIINKYQIDLDEILE 368
++ + +K H + K + L+ L+ + T+ E+ + ++ + +EIL+
Sbjct: 986 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 1045
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
+Q L + +LK E+ + L +L E + + + E + + + K
Sbjct: 1046 ---NLQKTLLDTEDKLKGAREENSGLLQELEELRKQAE--KAKAAQTAEDAMQIMEQMTK 1100
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
++ E L +KL+ ++ + +L +++ + L + + E KE
Sbjct: 1101 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME---EFRKE 1157
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS---LHEELTKLYKSKVDENNA 545
L+ A+ + L + +EV S L EE + L ++
Sbjct: 1158 IETLKQAAAQK-SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1216
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
IK EE +L+ +I+ L+EKD +L +L + + L+ EN S KSL+ V+
Sbjct: 1217 ESKFIKDADEEKASLQKSISITS---ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV 1273
Query: 606 -TREKETQASELE 617
T E + EL+
Sbjct: 1274 QTLESDKVKLELK 1286
>AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein
protein.
Length = 1843
Score = 77.8 bits (183), Expect = 2e-13
Identities = 228/1113 (20%), Positives = 445/1113 (39%), Gaps = 92/1113 (8%)
Query: 41 QSNPIKLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEG-KYQ 96
Q N L D+ + + +L+E + +++ ++ + L DI+ K+ +E K
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 97 N-LILETQT--RDLL------MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEEN 147
N ++LET+T D L ++ LE ENL ++ ++ KKI EL EEN
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 148 DTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKL 207
TL +++ ES +L E++ + + +E L VNE + K L
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 208 KENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGRE---DCKELCEDF 263
+ ++ L D+ ++ + + R +K + L++E+ ++ +C+ L +D
Sbjct: 473 TKT-VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 264 TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKD 323
K LE T+ E L EN+E + +K++ + +LN L ++
Sbjct: 532 MKEKAQLE-----KTI---ETLRENSE---RQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 324 HI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNECT 381
+ D K++ +L TS + +I + K +++ E E+ +++ +L+
Sbjct: 581 RVKDIEKEN--KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
E + + +K+ +L EK A + ER + T+D K E L KE
Sbjct: 639 KENELLQKKITNLKITC-EKIEALEQENSELERENR-KLKKTLDSFKNLTFQLESLEKEN 696
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLETGTAKA 499
+L + +++ R+++ A K+ L + EL +++K E L+ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQL---QLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDA 559
+ TLE ++ +++ L EL L + + NL +KI S+ ++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLEQ 812
Query: 560 LKIAIAKNEEKMLSLS------EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
L+ E++ L EK+NK + I E N++K N + +E +T +
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN--LEKENKTLS 870
Query: 614 SEL---ERSCQVIKQ---NGFELDK-----MKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
E+ + SC +K+ EL K +K + + D K
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 663 E-QNLAL-KEQC--EEKTRDCSR---LEINIK-THEKTAEIQNRMIMRLQKQIQEDDKLF 714
E + + L KE+ +E++ D SR LE ++ T +K+ EI+ I L+ +++E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
Query: 715 IEKETKLNELTNKYEALKRDYD--------AAVKDLESSREAVNQLTTQKDL-VEGRIAE 765
+ +L + YEALK+ D + ++ E +Q TT++ L V+ R+ E
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI 825
+E + T Q + L E + + V
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV- 1109
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK--EKLSL- 882
E S L + S + L + L++E E+ + ++ L K EKL L
Sbjct: 1110 ---ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1166
Query: 883 -EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN---LHSVVVDRMSYDAEVEKNKR 938
E+Q S + I ++ K +V ED N ++ + +VE+ K
Sbjct: 1167 HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1226
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L++ + + K + + Y++ KE E + + ++ K+ L K L
Sbjct: 1227 LLEN-KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 999 DEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVALEKQIES--LSNTPVSNST 1055
+ E E +Q + +L + ++ ++ L + L QI++ L N +
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLI 1088
M + Q Q I + + ++ +K+ K++
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIM 1378
Score = 62.5 bits (145), Expect = 8e-09
Identities = 150/752 (19%), Positives = 315/752 (41%), Gaps = 76/752 (10%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
I + + +L+E E+ + +L + ELK + ++ N L+ + + R + + +
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRDELDAL 315
Query: 416 HEISSAVTIDIVKKE-NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
E AV +D ++ E + KE L ++ K +++ ++ +Q L K T+L D L
Sbjct: 316 RE--KAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK--TMLEDQLEG 369
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
S +E+EKE L+L+ + + + +S+ E L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 535 LYKSKVDENNANLNLI--KILSEEIDALKIA-IAKNEEKMLSLSEKDNKLTELVSTINGL 591
++ + + L+ K L E++ L + + K E + SL++ +L V ++ G
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+ ++ N ++++ E +E+ + Q + QN L K D++
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSL-QNCQNLSK---DLMKEKAQLEKTIETL 545
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+ +LEQ Q R R +I+ + K E +N++ L + I+E
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKI---LHESIKETS 600
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI- 770
+ E + ++ + E K + A ++LE+ ++ L + +L++ +I L+
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERA-EELENE---LHHLEKENELLQKKITNLKITCE 656
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
+ E TF E+ + EN +LD+ + E+
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-ENSQLDEE---------NLEL 706
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLK 890
+ E L ++ L+ KEL+ E E + L+ + + K E+L + Q +++
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL--KASFKKTERLEVSYQGLDIE 764
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKK 950
Q R Q+ +E K + + L + ++ + +E+ K K +E+L +
Sbjct: 765 NQ-RLQKTLENSNK------KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
+ L+ ++++K ++ K++K ++ E++D LEE + L++E +T ++ +
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLR-QQAEIKD--TTLEENNVKIGNLEKENKTLSKEIG 874
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI 1070
+E C RLKE LEK+ + L V +T+ + T +V ++
Sbjct: 875 IYKESCVRLKE-----------------LEKENKEL----VKRATIDIKT---LVTLRE- 909
Query: 1071 TDVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
D++ E K ++MN L + + K G N+E
Sbjct: 910 -DLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 36.3 bits (80), Expect = 0.61
Identities = 17/47 (36%), Positives = 28/47 (59%)
Query: 980 ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL 1026
EL D KA++ L+Q +E E+ C + L+Q E + KRL++ + L
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 819 KRSISVISDSEVSQLKERLLSCQ---QELDDLKERYKELD-DECETCAEYLQE---RDEQ 871
K S EV +L LL C Q+ ++ ER + LD D A ++QE E
Sbjct: 110 KNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN 169
Query: 872 CARLKKEK---LSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
L+ + +S E LK + ++ ++ + + ++ + E+ LH +
Sbjct: 170 VFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHA 227
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S A+ MK E ++ +L + K+++ + E E K ++L DCK E
Sbjct: 228 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQ-------ELEEKTEQLLDCKQE 280
Query: 988 LEELKQRYKELDEE 1001
LE+++ K L +E
Sbjct: 281 LEQMEIELKRLQQE 294
>AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein.
Length = 992
Score = 77.8 bits (183), Expect = 2e-13
Identities = 98/508 (19%), Positives = 208/508 (40%), Gaps = 25/508 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+N ++ ++K ++ ++ + LKE K + + L
Sbjct: 435 FMKN--KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL 492
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ + E + M+ + KQIQ+ + + ++++L + + +R + K +
Sbjct: 493 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 552
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E+ +E + Q ++ R+ L++D TA
Sbjct: 553 ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 612
Query: 803 DENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
E ++ +N K D K +S++ ++S+ + LL ++ L + D +T
Sbjct: 613 REKQEEIDNYKKDLKDLKEKVSLL-QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 671
Query: 862 AEYLQERDEQCARL-----KKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFADVAVNTDED 915
L+++ E+C ++ K + +LE + S E Q +ER+ ++ D + +
Sbjct: 672 EIALEQKKEECLKMESQLKKAHEAALEARAS--PEMSDRIQHLEREITRYKDESSKAQAE 729
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L ++ + + + +K ++++ + K Q+ K K ++ +EK E
Sbjct: 730 VDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEE 789
Query: 976 AKRKE--LEDCKAELEE-LKQ---RYKELDEECETCAEYLKQRE-----EQCKRLKEAKI 1024
A+R+E L D +L++ L++ R +EL+E + +RE E+ R K
Sbjct: 790 ARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQ 849
Query: 1025 ALEIVDKLSNQKVALEKQIESLSNTPVS 1052
E++ + K LE LS+T S
Sbjct: 850 VEELLMAMEKVKQELESMKAKLSSTQQS 877
Score = 59.3 bits (137), Expect = 8e-08
Identities = 148/744 (19%), Positives = 295/744 (39%), Gaps = 85/744 (11%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF----DIKEQKSALEG 93
I+ N + QDS + T + + +E+ ++ + E+ + ELF ++E + +E
Sbjct: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET 297
Query: 94 KYQNLILETQT-RDLL-MSQIKSLEMENLTKDKE-----------IKNLTDSLKTKSKKI 140
+ Q L ++ + LL M Q K L + +D E + +L L+ K K+
Sbjct: 298 QKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN 357
Query: 141 NELQEE--------NDTLSNLIMENVTESD------------NLNKEVDDLKKNNECLTQ 180
+ L+EE D+ ++ V E +L +E+ LK N T+
Sbjct: 358 SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
Query: 181 KCIDLEKL--VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ + K V S +K KN Q K + + + + L L SDS
Sbjct: 418 EREEEMKQMEVYRSHSKF-MKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK---- 472
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT------MDLDEKLGENNEFE 292
I L+ L A + L + +++ LE E + D+ E+ G E
Sbjct: 473 -QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKG-TQAGE 530
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
+K M ++K ++ ++ I N ++ +D + V + TT+ D +
Sbjct: 531 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 590
Query: 353 DNIINKYQIDLDEILEKYTK----VQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + ++ + E+ + Q +++ +LK + EK++ L L EKE ++L
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE--ASLL 648
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
++ E +S++ +KK++ LK + + E K LK++ + + +
Sbjct: 649 DLK-----EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 703
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE-AHNEVK 526
I E T Y+ E K + E + LE +VK
Sbjct: 704 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVK 763
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
++++ L + E + +++ D L +++ SL +KD+++ EL
Sbjct: 764 DQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN---DSSQQLQDSLRKKDDRIEELEE 820
Query: 587 TIN---GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ + E + + + E Q EL + + +KQ EL+ MKA +
Sbjct: 821 ALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ---ELESMKAKLSSTQQS 877
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQC-----EEKTRDCSRLEINI---KTHEKTAEI 695
E + LE+ L +K++ EK + + LE++ KT E+ A +
Sbjct: 878 LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAAL 937
Query: 696 ---QNRMIMRLQKQIQEDDKLFIE 716
++R++ +L++Q Q KL +
Sbjct: 938 KREKDRLVQQLKQQTQNRMKLMAD 961
Score = 39.5 bits (88), Expect = 0.065
Identities = 62/288 (21%), Positives = 125/288 (43%), Gaps = 18/288 (6%)
Query: 57 CKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR-DLLMSQIKSL 115
C +S + ++E L+ + S E+ D + +Y++ + Q D L+ +K +
Sbjct: 682 CLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 740
Query: 116 EMENLTKDK---EIKNLTD-SLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKE 167
E E KDK E+++LT +K ++KK+ L Q E + ++ E DNLN
Sbjct: 741 ENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 800
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKN-ICAQCKLK----ENLIQSLHIGYDNT 222
L+ + + +LE+ + ES + + AQ + E ++ L + +
Sbjct: 801 SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 860
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD 282
+L S+ +ST+ + + ++ L R + ++ E+ +K L + D +
Sbjct: 861 KQELE-SMKAKLSSTQQS-LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDAN 917
Query: 283 EKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
L E + + K + ++ +KR + L +QL + K D Y+D
Sbjct: 918 IALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 965
>AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein.
Length = 1003
Score = 77.8 bits (183), Expect = 2e-13
Identities = 98/508 (19%), Positives = 208/508 (40%), Gaps = 25/508 (4%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 386 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 445
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+N ++ ++K ++ ++ + LKE K + + L
Sbjct: 446 FMKN--KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL 503
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ + E + M+ + KQIQ+ + + ++++L + + +R + K +
Sbjct: 504 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 563
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E+ +E + Q ++ R+ L++D TA
Sbjct: 564 ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 623
Query: 803 DENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
E ++ +N K D K +S++ ++S+ + LL ++ L + D +T
Sbjct: 624 REKQEEIDNYKKDLKDLKEKVSLL-QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 682
Query: 862 AEYLQERDEQCARL-----KKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFADVAVNTDED 915
L+++ E+C ++ K + +LE + S E Q +ER+ ++ D + +
Sbjct: 683 EIALEQKKEECLKMESQLKKAHEAALEARAS--PEMSDRIQHLEREITRYKDESSKAQAE 740
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L ++ + + + +K ++++ + K Q+ K K ++ +EK E
Sbjct: 741 VDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEE 800
Query: 976 AKRKE--LEDCKAELEE-LKQ---RYKELDEECETCAEYLKQRE-----EQCKRLKEAKI 1024
A+R+E L D +L++ L++ R +EL+E + +RE E+ R K
Sbjct: 801 ARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQ 860
Query: 1025 ALEIVDKLSNQKVALEKQIESLSNTPVS 1052
E++ + K LE LS+T S
Sbjct: 861 VEELLMAMEKVKQELESMKAKLSSTQQS 888
Score = 59.3 bits (137), Expect = 8e-08
Identities = 148/744 (19%), Positives = 295/744 (39%), Gaps = 85/744 (11%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF----DIKEQKSALEG 93
I+ N + QDS + T + + +E+ ++ + E+ + ELF ++E + +E
Sbjct: 249 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET 308
Query: 94 KYQNLILETQT-RDLL-MSQIKSLEMENLTKDKE-----------IKNLTDSLKTKSKKI 140
+ Q L ++ + LL M Q K L + +D E + +L L+ K K+
Sbjct: 309 QKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN 368
Query: 141 NELQEE--------NDTLSNLIMENVTESD------------NLNKEVDDLKKNNECLTQ 180
+ L+EE D+ ++ V E +L +E+ LK N T+
Sbjct: 369 SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 428
Query: 181 KCIDLEKL--VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ + K V S +K KN Q K + + + + L L SDS
Sbjct: 429 EREEEMKQMEVYRSHSKF-MKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK---- 483
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT------MDLDEKLGENNEFE 292
I L+ L A + L + +++ LE E + D+ E+ G E
Sbjct: 484 -QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKG-TQAGE 541
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
+K M ++K ++ ++ I N ++ +D + V + TT+ D +
Sbjct: 542 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 601
Query: 353 DNIINKYQIDLDEILEKYTK----VQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + ++ + E+ + Q +++ +LK + EK++ L L EKE ++L
Sbjct: 602 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE--ASLL 659
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEI-LTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
++ E +S++ +KK++ LK + + E K LK++ + + +
Sbjct: 660 DLK-----EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 714
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE-AHNEVK 526
I E T Y+ E K + E + LE +VK
Sbjct: 715 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVK 774
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
++++ L + E + +++ D L +++ SL +KD+++ EL
Sbjct: 775 DQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN---DSSQQLQDSLRKKDDRIEELEE 831
Query: 587 TIN---GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ + E + + + E Q EL + + +KQ EL+ MKA +
Sbjct: 832 ALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ---ELESMKAKLSSTQQS 888
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQC-----EEKTRDCSRLEINI---KTHEKTAEI 695
E + LE+ L +K++ EK + + LE++ KT E+ A +
Sbjct: 889 LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAAL 948
Query: 696 ---QNRMIMRLQKQIQEDDKLFIE 716
++R++ +L++Q Q KL +
Sbjct: 949 KREKDRLVQQLKQQTQNRMKLMAD 972
Score = 39.5 bits (88), Expect = 0.065
Identities = 62/288 (21%), Positives = 125/288 (43%), Gaps = 18/288 (6%)
Query: 57 CKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR-DLLMSQIKSL 115
C +S + ++E L+ + S E+ D + +Y++ + Q D L+ +K +
Sbjct: 693 CLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 751
Query: 116 EMENLTKDK---EIKNLTD-SLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKE 167
E E KDK E+++LT +K ++KK+ L Q E + ++ E DNLN
Sbjct: 752 ENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 811
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKN-ICAQCKLK----ENLIQSLHIGYDNT 222
L+ + + +LE+ + ES + + AQ + E ++ L + +
Sbjct: 812 SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 871
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD 282
+L S+ +ST+ + + ++ L R + ++ E+ +K L + D +
Sbjct: 872 KQELE-SMKAKLSSTQQS-LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDAN 928
Query: 283 EKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
L E + + K + ++ +KR + L +QL + K D Y+D
Sbjct: 929 IALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 976
>AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransferase 9
protein.
Length = 978
Score = 77.0 bits (181), Expect = 4e-13
Identities = 200/1029 (19%), Positives = 412/1029 (40%), Gaps = 101/1029 (9%)
Query: 72 LKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
+K ++ +L + ++ LE + +N + + LM++ + L++ +++ +
Sbjct: 3 VKTSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQ 62
Query: 132 SLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE 191
+++ ++ L++ L L E L+K N E C + KLV
Sbjct: 63 EIESSRVELRSLEKIISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVI- 120
Query: 192 SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSE-LD 250
SE +I + +KE IQ LH T ++L++S+ N S +K+ +L++E +
Sbjct: 121 SELRI-------KLAIKEAEIQKLHANL--TANQLSQSLITCNDSQESSKLSSLETEPVK 171
Query: 251 AGREDCKELCEDFT--SIKNHLELHEPNMTMDLDEKLGE--NNEFETKAVKV-MSEIKRN 305
G E +D ++ E + ++E + E E +KV M+
Sbjct: 172 LGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQ 231
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE 365
+ E+L+ S SK L++E + + + L+E
Sbjct: 232 FQLIQEELLEKASNSSK-------------LESEMTKKCSQLLTL---------EKQLEE 269
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNILRIQKERIHEISSAVTI 424
+ Y+ + E EL NEK+ SL + + E E C + E+ +I
Sbjct: 270 KIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC----LAFEKAKKIHLEQHK 325
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
++ K+ L+ L K+ + + + + L QD+ + D L+T+ +
Sbjct: 326 EMEKQIERLEAQLEKKDQQFKEQEKTMSM-LQQDIICKQHHLESLDRLLTESKGEMKKEN 384
Query: 485 IEK-EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDEN 543
++K E L+ + L N+++ E+ K K K +E
Sbjct: 385 MKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 444
Query: 544 NANLNLIKI----LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK 599
+KI L E + I +++ L ++ + EL T L+++ +
Sbjct: 445 YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ---VS 501
Query: 600 SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK 659
L + +++E+ A +L + + + E D + ++ +E
Sbjct: 502 KLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 561
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
+ ++ + LK E K S+L++ I KT E++ + ++E +KL ET
Sbjct: 562 KMEKEIMHLKRDGENKAMHFSQLDM-ILDQTKT-ELEKKT-----NAVKELEKLQHSTET 614
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVX 779
+L E K E L+ + A +L+S+ + QL +D+++ LE T + T
Sbjct: 615 ELTEALQKREVLETELQNAHGELKST---LRQLQELRDVLQKAQLSLEEKYTTIKDLTAE 671
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ N +L + + + + +++++++
Sbjct: 672 LRECKMEIEDEKQELLEMDQALKERNWELKQRA----AQVTHLDMTIREHRGEMEQKIIK 727
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQP 898
+ L+ + KE + + E+ + LQ EQ + L EQ++S LK++I RTQQ
Sbjct: 728 LEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 787
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ + SV+ ++ Y A + K + ++LR ++ ++N+ T
Sbjct: 788 MKE-----------------MESVMKEQEQYIAT--QCKEAIDLGQKLRLTREQVQNSHT 828
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
++ +A + ++ +A+R E+E +ELE++KQ KE D AE L + +
Sbjct: 829 ELAEA------RHQQVQAQR-EIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 881
Query: 1019 LKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
L EA++ EI KLS + +L++ + N + I + Q + V + N+
Sbjct: 882 L-EARMQAEI-KKLSAEVESLKEAYHMEMISHQENHAKW-----KISADSQKSSVQQLNE 934
Query: 1079 KLKKMNAKL 1087
+L+K +L
Sbjct: 935 QLEKAKLEL 943
Score = 72.5 bits (170), Expect = 8e-12
Identities = 127/598 (21%), Positives = 254/598 (42%), Gaps = 62/598 (10%)
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
LI+I +E D LK+ +A + + E+ L E S N K E+ K + ++T E
Sbjct: 211 LIQIEAENSD-LKVNMAHRTSQFQLIQEE---LLEKAS--NSSKLESEMTKKCSQLLTLE 264
Query: 609 KETQASELERSCQVIKQNGFELDKMKAD--ILMXXXXXXXXXXXXXXXXDEAKSL-LEQN 665
K+ + + S K E + M+ + I ++AK + LEQ+
Sbjct: 265 KQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQH 324
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN-EL 724
+++Q E + + K EKT + + I+ Q ++ D+L E + ++ E
Sbjct: 325 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 384
Query: 725 TNKYEALKR------DYDAAVKDLESSREAVNQ-LTTQKDLVEGRIAELESDIRTEQTAT 777
K EALK + V+ L+S+ E + L + +EG + E ++ +
Sbjct: 385 MKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 444
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFG---DENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
+ + + + + + + +VS+L+
Sbjct: 445 YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE 504
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL----KKEKLSLEQQVSNL- 889
+ L Q++ + E+ ++++++CE+ A + ++ L ++ K+ ++Q L
Sbjct: 505 QEL---QKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 561
Query: 890 ---KEQIRTQQPVERQAK-FADVAVNTDEDWANLHSVV-----VDRMSYDAEVEKNKRLM 940
KE + ++ E +A F+ + + D+ L ++++ + E E + L
Sbjct: 562 KMEKEIMHLKRDGENKAMHFSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQ 621
Query: 941 K--TIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-------RKELEDCKAELEE 990
K +E EL+ +LK+T+ ++Q+ + K E K EL +CK E+E+
Sbjct: 622 KREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIED 681
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRL----KEAKIALE-IVDKLSN--QKVALE--- 1040
KQ E+D+ + LKQR Q L +E + +E + KL +K LE
Sbjct: 682 EKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE 741
Query: 1041 --KQIESLSNTPVSNSTMYVATGSAI-VQN-QQITDVMKENQKLKKMNAKLITICKKR 1094
KQIESL N + N+ + I +QN Q+I+ + KE ++ ++ ++ ++ K++
Sbjct: 742 CNKQIESL-NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQ 798
Score = 57.2 bits (132), Expect = 3e-07
Identities = 122/632 (19%), Positives = 268/632 (42%), Gaps = 69/632 (10%)
Query: 65 ESSNEINLKLEKLSGELF----DIKEQKSALEGKYQNLILET---QTRDLLMSQIKS-LE 116
E E+ ++E+L +L KEQ+ + Q++I + ++ D L+++ K ++
Sbjct: 322 EQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK 381
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESD-NLNKEVDDLKKNN 175
EN+ KD+ +K L + + ++ K+ +L + ++ ++ + + N K LKK +
Sbjct: 382 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 441
Query: 176 ECLTQKCIDLE-KLVNESENKIGPKNICAQCKL--KENLIQSLHI---GYDNTLSKLNRS 229
E C+ E K+ N S + +N+ Q L ++ ++Q I ++T +KL +
Sbjct: 442 E--EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ 499
Query: 230 ISD---------SNTSTRYNKI---C-TLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
+S +++ + K+ C + E D R+ EL +K ++ ++
Sbjct: 500 VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 559
Query: 277 MTMDLDEKLGENNEFETKAV----------KVMSEIKRNLNSLSE-QLINNESKKSKDHI 325
++ E + + E KA+ + +E+++ N++ E + + + ++
Sbjct: 560 LSKMEKEIMHLKRDGENKAMHFSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 619
Query: 326 DRYKDSLLAVLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSEL 384
+ ++ L L G + ++ + +++ K Q+ L+E + +L EC E+
Sbjct: 620 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 679
Query: 385 KSVNEKLASLNSQLIE-----KENACNILRIQKERIHEISSAVTIDIVKKENELK--EIL 437
+ ++L ++ L E K+ A + + I E + I+K E L+ E+
Sbjct: 680 EDEKQELLEMDQALKERNWELKQRAAQVTHLDM-TIREHRGEMEQKIIKLEGTLEKSELE 738
Query: 438 TKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE--TG 495
KEC K + D ++ + L + F L + E+S+ EIE+ + R++
Sbjct: 739 LKECNKQIESLNDKLQNAKEQLREKE-----FIMLQNEQEISQLKKEIERTQQRMKEMES 793
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL------YKSKVDENNANLNL 549
K L +V++ H EL + + +++ ++ L
Sbjct: 794 VMKEQEQYIATQCKEAIDLGQKLRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 853
Query: 550 IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL--NDVITR 607
+K LS+E DA +A EE S + + + + I L E SLK ++I+
Sbjct: 854 MKQLSKEKDAHGNHLA--EELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 911
Query: 608 EKETQASELERSCQ--VIKQNGFELDKMKADI 637
++ ++ Q ++Q +L+K K ++
Sbjct: 912 QENHAKWKISADSQKSSVQQLNEQLEKAKLEL 943
Score = 51.2 bits (117), Expect = 2e-05
Identities = 121/582 (20%), Positives = 233/582 (40%), Gaps = 78/582 (13%)
Query: 76 KLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
++S E +++ SALE + L+L L + E + K +E+ L LK
Sbjct: 397 QVSEETIKVRQLDSALEICKEELVLHLNQ---LEGNKEKFEKQLKKKSEEVYCLQKELKI 453
Query: 136 KSKKINELQEENDTLSNLIMEN--VTESDNL-NKEVDDLKKNNECLTQKCI-DLEKLVNE 191
K+ + E E+N L + + + + + + + N E++D + E K +L+K
Sbjct: 454 KNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRES 513
Query: 192 SENKIGP-----KNICAQCKLKENLIQSLH----------IGYDNTLSKLNRSISDSNTS 236
S K+ ++ + LK + L Y LSK+ + I
Sbjct: 514 SAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 573
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
NK S+LD + K E T+ LE + + +L E L + ET+
Sbjct: 574 GE-NKAMHF-SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQ 631
Query: 297 KVMSEIKRNLNSLSE--------QL-----------INNESKKSKDHIDRYKDSLL---- 333
E+K L L E QL + E ++ K I+ K LL
Sbjct: 632 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDEKQELLEMDQ 691
Query: 334 AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYT----KVQGDLNECTSELKSVNE 389
A+ + + +D I +++ ++++ + K K + +L EC +++S+N+
Sbjct: 692 ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLND 751
Query: 390 KLASLNSQLIEKE-----NACNILRIQKERIHEISSAVTIDIVKKENELKEILT--KECL 442
KL + QL EKE N I +++KE ++ V KE E + I T KE +
Sbjct: 752 KLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQE-QYIATQCKEAI 810
Query: 443 KL-SKLKI----------DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR 491
L KL++ ++ Q + A ++I L L +LS+ + + L
Sbjct: 811 DLGQKLRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSK-EKDAHGNHLA 869
Query: 492 LETGTAKA----VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL 547
E G +K + ++L+EA++ H+E +K D ++
Sbjct: 870 EELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSS- 928
Query: 548 NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
++ L+E+++ K+ + + ++ + +L ++ E++ N
Sbjct: 929 --VQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAAN 968
>AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated protein
CEP110 protein.
Length = 994
Score = 77.0 bits (181), Expect = 4e-13
Identities = 204/1052 (19%), Positives = 424/1052 (40%), Gaps = 108/1052 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
++ S + ++E+L + D+ ++K +LE + + L Q R I +E+L
Sbjct: 14 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQRQKDFIDG-NVESLMT 72
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD----LKKNNECL 178
+ EI+ SLK ++E++ TL E + E+D L E + K+ +
Sbjct: 73 ELEIEK---SLKHHEDIVDEIECIEKTLLKRRSE-LREADRLLAEAESELSCTKEKTKNA 128
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTST 237
+K D ++ + ++E+ AQ + NL+++ D L L D
Sbjct: 129 VEKFTDAKRSLLQTESDAEELERRAQ-ETAVNLVKA-----DQQLRSLQADAKDLEQHKI 182
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAV 296
+ +I +++ A ++ DF + E L E + D ++ E NE V
Sbjct: 183 KQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV 236
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
SE+ Q E +K K + + + AVLD + G ++ L+ +
Sbjct: 237 LKESEVLL-------QAKRAELEKLKSQVTSQQQEM-AVLDRQLGHKKEELH--LLQGSM 286
Query: 357 NKYQIDLDEILE----KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + DL E L + T+ + E S L+ ++ + LN Q+ E++ +++ +
Sbjct: 287 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 346
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
E+ E V + K + EL+ IL + L+L ++ + + + D
Sbjct: 347 EKEEENLQVVLRQMSKHKTELQNIL--DMLQLENHEL-------------QGLKLQHDQR 391
Query: 473 ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT--LEEAHNEVKSLHE 530
++ EL +T + +EKL LE + D +E E ++L
Sbjct: 392 VS--ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQS 449
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+ L K K D L E+ D + +A+ + ++L+ +E+++K+ + S +
Sbjct: 450 CVECLSKEKED-----------LQEKCDIWEKKLAQTK-RVLAAAEENSKMEQ--SNLEK 495
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L L+ D + R+K + +++ Q +++ ++ ++ ++
Sbjct: 496 LDLNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------ANVQDHL 549
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
D + Q++ L EQ + +D S + +K E + + + LQ +I+E+
Sbjct: 550 NLAKQDLLHTTKHQDVLLSEQTRLQ-KDISEWANRFEDCQKEEETKQQQLQVLQNEIEEN 608
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREAVNQLTTQK---DLVEGRIAEL 766
+++E L + E+ + + + L E + +LT QK D V ++
Sbjct: 609 KLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAA 668
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI- 825
E +RT Q +++ +L K DS + S++
Sbjct: 669 EERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR 728
Query: 826 ---------SDSEVSQLKERLLSCQQELD-DLKERYKE---LDDECETCAEYLQERDEQC 872
++ +V+ LKE L + +L+ +L E+ +E + E T Q+ E+
Sbjct: 729 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 788
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RMSYD 930
RL KE ++ + + LK+Q+ Q+ +ER+ A+ T L S V D R S
Sbjct: 789 RRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT------LKSEVKDEIRTSLK 842
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ L +E + + ++L+ + +++ + +T + FE K L + + +
Sbjct: 843 NLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEEK---LNFSQVHIMD 898
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
R + L E+ + LK + C K+A++ ++ + +L +Q+++L
Sbjct: 899 EHWRGEALREKLRHREDRLKAQLRHCMS-KQAEVLIKGKRQTEGTLHSLRRQVDALGELV 957
Query: 1051 VSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
S S ++ S +T+ + Q +K
Sbjct: 958 TSTSADSASSPSLSQLESSLTEDSQLGQNQEK 989
Score = 52.4 bits (120), Expect = 9e-06
Identities = 101/547 (18%), Positives = 210/547 (38%), Gaps = 35/547 (6%)
Query: 551 KILSEEI--DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
KI EEI + KI AK+ + LS+K KLTE E L+ ++ R
Sbjct: 181 KIKQEEILKEINKIVAAKDSD-FQCLSKKKEKLTE----------ELQKLQKDIEMAERN 229
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
++ L+ S +++ EL+K+K+ + +E L +
Sbjct: 230 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 289
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K +E R E+ K + E+++ ++ L Q E + E++T+L + +
Sbjct: 290 KADLQEALR-LGETEVTEKCNH-IREVKS-LLEELSFQKGELNVQISERKTQLTLIKQEI 346
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E + + ++ + + + + D+++ EL+ ++ + V
Sbjct: 347 EKEEENLQVVLRQMSKHKTELQNIL---DMLQLENHELQG-LKLQHDQRVSELEKTQVAV 402
Query: 789 XXXXXXXXXXXTFGDENR-DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + ++ +L + KR I ++ L SC + L
Sbjct: 403 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-----RMTAESRALQSCVECLSKE 457
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
KE +L ++C+ + L + A ++ + + L +R Q Q
Sbjct: 458 KE---DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLDLNVRKLQQELDQLNRDK 514
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
++++ D A + R + ++ E+ L + L KQDL +T + +
Sbjct: 515 LSLHNDIS-AMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQ 570
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
T+ K+ EDC+ E E +Q+ + L E E L Q+E +RL++ + + E
Sbjct: 571 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 630
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
KL KV L++Q L + S ++ ++ ++E ++ + K
Sbjct: 631 --SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 688
Query: 1088 ITICKKR 1094
++ K++
Sbjct: 689 LSQTKRQ 695
Score = 46.4 bits (105), Expect = 6e-04
Identities = 149/790 (18%), Positives = 316/790 (40%), Gaps = 59/790 (7%)
Query: 2 LNNDNRIMFXXXXXXXXXXXXXRNQLDGAKSKNDNIIETQSNPIKLQDSG--TITISCKM 59
L +R++ +N ++ ++++T+S+ +L+ T K
Sbjct: 104 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 163
Query: 60 CQSLKE-SSNEINLKLEKLSGE--LFDIKEQKSALEGKYQNLILETQ--TRDLLMSQIKS 114
Q L+ ++ +L+ K+ E L +I + +A + +Q L + + T +L Q K
Sbjct: 164 DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ-KD 222
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+EM +D ++ L +S K EL++ +++ E L + ++L
Sbjct: 223 IEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL 282
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSN 234
+ Q DL++ + E ++ K C + ++L++ L +LN IS+
Sbjct: 283 QGSMVQAKADLQEALRLGETEVTEK--CNHIREVKSLLEELSF----QKGELNVQISERK 336
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKN-----HLELHE-PNMTMDLDEKLGEN 288
T K ++ E + + +++ + T ++N LE HE + + D+++ E
Sbjct: 337 TQLTLIK-QEIEKEEENLQVVLRQMSKHKTELQNILDMLQLENHELQGLKLQHDQRVSEL 395
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ + ++ E++ NL +S+Q E + K ++R K + + AE V
Sbjct: 396 EKTQVAVLEEKLELE-NLQQISQQQ-KGEIEWQKQLLERDKRE-IERMTAESRALQSCVE 452
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
+ + + + D+ E TK E S+++ N + LN + +++E + L
Sbjct: 453 CLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLDLNVRKLQQE--LDQL 510
Query: 409 RIQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKK 464
K +H SA+ + +K N L+E L L+ K D+ QD+ ++
Sbjct: 511 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 570
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D I+++ D + E+E + + + F L+
Sbjct: 571 TRLQKD--ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ----- 623
Query: 525 VKSLHEELTKLYKSKVDENNANLNLIKILSEE---IDALKIAIAKNEEKMLSLSEKDNKL 581
K E +KL SKV L K L+++ +D + + EE++ +L E++
Sbjct: 624 -KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC 682
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
L T++ K + E+E Q E +++ E D M+AD +
Sbjct: 683 ESLEKTLSQTKRQ-----------LSEREQQLVEKSGELLALQK---EADSMRADFSLLR 728
Query: 642 XXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI 700
K L+ Q L++ E+ ++ S ++ + T E A+ +
Sbjct: 729 NQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERA 788
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
RL K++ + + E + ++ E + + A++ L+S E +++ T +
Sbjct: 789 RRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS--EVKDEIRTSLKNLN 845
Query: 761 GRIAELESDI 770
+ EL +D+
Sbjct: 846 QFLPELPADL 855
>AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golgin
subfamily a, 4 variant protein.
Length = 1310
Score = 77.0 bits (181), Expect = 4e-13
Identities = 151/737 (20%), Positives = 315/737 (42%), Gaps = 74/737 (10%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLM---SQIKSLEMENL 120
+E ++ + LEK E I ++K E LE Q + +L ++++ L+ E
Sbjct: 536 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE-LELQKKAILTESENKLRDLQQEAE 594
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT- 179
T I L SL+ KS + N+ Q + D +L E + + V+ K E L
Sbjct: 595 TYRTRILELESSLE-KSLQENKNQSK-DLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 652
Query: 180 -QKCIDLEKL-VNESENKIGPKNICAQCKL-KENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q + EKL V + + + + + +C+ KE L++ I + + ++N +
Sbjct: 653 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK-LD 711
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN------- 289
+ ++ +L SEL + +L E+ + +K+ + + + +DE+ +
Sbjct: 712 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 771
Query: 290 -EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
E E + +K +N L E L+ K K+H + ++L A + G L
Sbjct: 772 KEHEVSIQRTEKALKDQINQL-ELLLKERDKHLKEH-QAHVENLEADIKRSEG--ELQQA 827
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNI 407
+D + YQ E + Y + L + +L++ L +++ +K++ C
Sbjct: 828 SAKLD-VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 886
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L K ++ ++ + +K+N E K ++ + K++ D +++ K+I +
Sbjct: 887 LDAHKIQVQDLMQQL-----EKQNSEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILV 938
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
+ +I Q E +K+++ + T A F E+ +VK
Sbjct: 939 EKENMILQMR------EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 992
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE----KMLSLSEKDNK-LT 582
+E+ + K K+ + A L +E++ + +++ E+ KML +++ ++ ++
Sbjct: 993 KAKEMQETLKKKLLDQEAKLK------KELENTALELSQKEKQFNAKMLEMAQANSAGIS 1046
Query: 583 ELVSTIN-GLKEENNSL-----KSLNDVIT---REKETQASELERSCQV-IKQNGFELDK 632
+ VS + KE+ SL + LNDVI+ ++ QA EL+ ++ +++ E+ +
Sbjct: 1047 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAE 1106
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL---EINIKTH 689
+K IL+ +E L+EQ ++K+ + L E +K H
Sbjct: 1107 LKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAH 1166
Query: 690 EKTAEIQ-NRMIMR---LQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAA 738
+ E+ N+ + LQ+Q+ E L E + K++ELT+K +++LK ++ +
Sbjct: 1167 LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKS 1226
Query: 739 VKDLESSREAVNQLTTQ 755
K LE +L+ +
Sbjct: 1227 NKSLEDKSLEFKKLSEE 1243
Score = 69.7 bits (163), Expect = 5e-11
Identities = 180/986 (18%), Positives = 404/986 (40%), Gaps = 76/986 (7%)
Query: 38 IETQSNPIKLQDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ 96
+ET +K Q++ + CK QS KE + + E L +L E+ LE K +
Sbjct: 312 LETLQQRVKRQEN--LLKRCKETIQSHKEQCTLLTSEKEALQEQL---DERLQELE-KIK 365
Query: 97 NLILETQTRDLLMSQIKSLE--MENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLI 154
+L + +T+ L++Q++ + +E L +DK + + ++ + + + +EE L + I
Sbjct: 366 DLHMAEKTK--LITQLRDAKNLIEQLEQDKGMV-IAETKRQMHETLEMKEEEIAQLRSRI 422
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
+ T+ + L ++ + ++ +K + + E+ K+ + + Q K E +
Sbjct: 423 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE-MDEQIKTIEKTSEE 481
Query: 215 LHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHE 274
I LS++ + + D + +I LQ + KEL + L+ E
Sbjct: 482 ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE------KELARKEQELTKKLQTRE 535
Query: 275 PNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
+ L ++ +++ +K+ E ++ E L E + K I ++ L
Sbjct: 536 REFQEQMKVALEKS---QSEYLKISQEKEQQ-----ESLALEELELQKKAILTESENKLR 587
Query: 335 VLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASL 394
L E T + E L ++ Q + ++ + ++ + N+ E+ + EK +
Sbjct: 588 DLQQEAETYRTRILE-LESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 646
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
L +++A + E++ + ++ K + ++ KE L K +I
Sbjct: 647 LESLKHQQDA-----LWTEKLQVLKQQYQTEMEKLREKCEQ--EKETLLKDK-EIIFQAH 698
Query: 455 LDQDLPAHKKITILFDALITQYE-LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXX 513
+++ ++K D T+ E LS E+ K + +LE +
Sbjct: 699 IEE---MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAK 755
Query: 514 XFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDA-LKIAIAKNEEKML 572
+ +V S+ +E + +N +++L +E D LK A E
Sbjct: 756 MDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA 815
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+ + +L + + ++ + S +S T+ E Q ++L++ ++ L K
Sbjct: 816 DIKRSEGELQQASAKLDVFQ----SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK 871
Query: 633 MKADI-LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC-SRLEINIKTHE 690
A++ D + L +QN ++++ + T+ S+LE K E
Sbjct: 872 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 931
Query: 691 KTAEI---QNRMIMRLQKQIQEDDKLFIEKET-KLNELTNKYEALKRDYDAAVKDLESSR 746
+T +I + MI+ Q++E K IE T KL+ + L +Y+ K+ E
Sbjct: 932 QTKQILVEKENMIL----QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 987
Query: 747 EAVNQLTTQ-KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDEN 805
E V Q + ++ ++ ++ + E+ ++ E T + G +
Sbjct: 988 EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1047
Query: 806 RDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
+L+ + K I +++ +L + + +++L+ E +E+ + L
Sbjct: 1048 AV----SRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEI------QL 1097
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIR--TQQPVERQAKFADVAVNTDEDWANLHSVV 923
QE++++ A LK++ L + + ++I ++ V++ ++ + A+++S+
Sbjct: 1098 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1157
Query: 924 VDRMSYDAEVEKNK-RLMKTIEELRYKKQ---DLKNTVTKMQKAMEKYTKK----DKEFE 975
D A +EK + L K+++E + ++ +LK + ++ + + T K D+EF+
Sbjct: 1158 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQ 1217
Query: 976 AKRKELEDCKAELEELKQRYKELDEE 1001
+ + E LE+ +K+L EE
Sbjct: 1218 SLKSSHEKSNKSLEDKSLEFKKLSEE 1243
Score = 58.0 bits (134), Expect = 2e-07
Identities = 146/657 (22%), Positives = 267/657 (40%), Gaps = 63/657 (9%)
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIH----EISSAVTID--IVKKENELKE 435
S++ S E L NS + KE LR + + + S VT + +++ +L+
Sbjct: 149 SDMDSEAEDLVG-NSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 207
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE--LSRTDYEIEKEKLRLE 493
IL++ K + ++ +L D A K + FDA + + + +S ++ K RL
Sbjct: 208 ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 267
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT--KLYKSKVDENNANLNLIK 551
G F E ++ + + E+ T K ++ NL+K
Sbjct: 268 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 327
Query: 552 ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKET 611
E I + K E+ L SEK+ L E L E L+ + D+ EK
Sbjct: 328 RCKETIQSHK------EQCTLLTSEKE-ALQEQ------LDERLQELEKIKDLHMAEKTK 374
Query: 612 QASELERSCQVIKQNGFELDKMKADIL-MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
++L + +I+Q + + A+ K + Q L+E
Sbjct: 375 LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 434
Query: 671 QCEEKTRDC-SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
Q E+ R LE + T +KT E + ++ + +QI+ +K E+ L + ++
Sbjct: 435 QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSR-- 492
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
+K++ +K +SS E + +L QK L E +A E ++ T++ T
Sbjct: 493 -VKQEVVDVMK--KSSEEQIAKL--QK-LHEKELARKEQEL-TKKLQTREREFQEQMKVA 545
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
+ ++ E+ L++ + +++++SE +L QQE + +
Sbjct: 546 LEKSQSEYLKI--SQEKEQQESLALEELELQKKAILTESE-----NKLRDLQQEAETYRT 598
Query: 850 RYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA 909
R EL+ E + LQE Q L + LE + + ++I T + + + +
Sbjct: 599 RILELESSLE---KSLQENKNQSKDLA---VHLEAEKNKHNKEI-TVMVEKHKTELESLK 651
Query: 910 VNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
D W V+ + Y E+EK + K +E K+ LK+ Q +E+ +
Sbjct: 652 HQQDALWTEKLQVL--KQQYQTEMEKLRE--KCEQE---KETLLKDKEIIFQAHIEEMNE 704
Query: 970 KDKE-FEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
K E + K+ ELE +EL E LK R+K L+EE LK + ++ K+ EAK+
Sbjct: 705 KTLEKLDVKQTELESLSSELSEVLKARHK-LEEELSV----LKDQTDKMKQELEAKM 756
Score = 53.6 bits (123), Expect = 4e-06
Identities = 150/825 (18%), Positives = 325/825 (39%), Gaps = 56/825 (6%)
Query: 289 NEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
++ + K+++ ++E++ L +Q ++ D KD ++VL + +
Sbjct: 210 SQSQDKSLRRIAELREELQM--DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 267
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKS-VNEKLASLNSQLIEKENACNI 407
M+ + K L+ E +TK + ++ ++ + K Q ++++ N+
Sbjct: 268 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQE--NL 325
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
L+ KE I T+ +KE L+E L + +L K+K DL K IT
Sbjct: 326 LKRCKETIQSHKEQCTLLTSEKE-ALQEQLDERLQELEKIK-----DLHM-AEKTKLITQ 378
Query: 468 LFDA--LITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
L DA LI Q E + E ++ ET K + + E+
Sbjct: 379 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 438
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
++ EEL K + A L + E+I ++ +EE+ +SL ++ +++ +
Sbjct: 439 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE---KTSEEERISLQQELSRVKQ 495
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
V + K + L + +E + EL + Q ++ F+ ++MK +
Sbjct: 496 EVVDVMK-KSSEEQIAKLQKLHEKELARKEQELTKKLQT-REREFQ-EQMKVALEKSQSE 552
Query: 644 XXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
A LE Q A+ + E K RD + +T + E+++ +
Sbjct: 553 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT--RILELESSLEKS 610
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV---------NQLT 753
LQ+ + L + E + N+ + + + ++ L+ ++A+ Q
Sbjct: 611 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 670
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
T+ + + + E E + + + + +L E K
Sbjct: 671 TEMEKLREK-CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 729
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
+ +SV+ D + ++K+ L + ++D+ K +++ D E +R E+
Sbjct: 730 ARHKLEEELSVLKD-QTDKMKQEL---EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL 785
Query: 874 R--LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ + + +L L+++ +LKE Q VE AD+ + E + V + A
Sbjct: 786 KDQINQLELLLKERDKHLKEH---QAHVENLE--ADIKRSEGELQQASAKLDVFQSYQSA 840
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
E+ K + + +L+ K DL+ + TK+ E EA++K++ C EL+
Sbjct: 841 THEQTKAYEEQLAQLQQKLLDLETERILL-------TKQVAEVEAQKKDV--C-TELDAH 890
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPV 1051
K + ++L ++ E ++Q+ + ++ E+K+ ++ +++ +EK+ L
Sbjct: 891 KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREG 950
Query: 1052 SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+ + T + I + +E + K K + K++ K
Sbjct: 951 QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 995
>M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protein-170
alpha-2 protein.
Length = 1392
Score = 76.2 bits (179), Expect = 6e-13
Identities = 177/880 (20%), Positives = 341/880 (38%), Gaps = 67/880 (7%)
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKR 304
L +E D R + + I+ L L + E + ++ T E
Sbjct: 367 LLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVE 426
Query: 305 NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD--VFEILMDNIINKYQI- 361
LN L E E +K +D R ++ + D E T S + E+ D + ++
Sbjct: 427 LLNQLEE-----EKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ---KERIH-- 416
+L LE K GD++ S L+ ++ L + + L+ +E H
Sbjct: 482 ELRRRLES-NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK 540
Query: 417 EISSAVTI-DIVKKENE-LKEIL------TKECLKLSKLKIDIPRDLDQDLPAHKKI--- 465
EI + T + + KENE LK L + + L K K++ Q K+
Sbjct: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 600
Query: 466 ------TILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
T F L TQ E R DY+ E E L+ + + +A ++
Sbjct: 601 KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL--MKVIK 658
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
E N ++++ +L K + E LN ++ ++ L++ AK E+ + DN
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI---DN 715
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILM 639
++L +T L + + K+ ++ + K+ + +LE + + IK E++K
Sbjct: 716 FTSQLKATEEKLLDLDALRKASSEGKSEMKKLR-QQLEAAEKQIKH--LEIEKN------ 766
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ + L++NL+ Q +E E+ I EK AE
Sbjct: 767 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK----ELQI-LKEKFAEASEEA 821
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
+ +Q+ +QE +KE + N L++ E L+ + E QL K+ +
Sbjct: 822 VS-VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 880
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD---- 815
E IAE+ + + ++ + T +EN + D
Sbjct: 881 ENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
Query: 816 -DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE-TCAEYLQERDEQCA 873
+ ++ + + E +L+ +L +++++ + +EL E +E + +E
Sbjct: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999
Query: 874 RLKKEKLSLEQQVSNLKEQ----IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
L+K L E ++ +E+ ++ + + +QA+ A A ++ + + ++
Sbjct: 1000 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTET 1059
Query: 930 DAEVEKNKRL-MKTIEEL-RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
A +E K+ K EL K+ +LKN V ++ K+ E T ++++ E RKE+E K
Sbjct: 1060 LASLEDTKQTNAKLQNELDTLKENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQA 1118
Query: 988 LEELKQRYKELDEECETCAEYL-KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ Q+ L EE AE L + R+E K + + ++L K K I+
Sbjct: 1119 AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDA 1178
Query: 1047 SNTPVSNSTMYVATGSAIVQ-NQQITDVMKENQKLKKMNA 1085
S T + + + + ++ + E L+ NA
Sbjct: 1179 DEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1218
Score = 70.9 bits (166), Expect = 2e-11
Identities = 147/738 (19%), Positives = 304/738 (41%), Gaps = 66/738 (8%)
Query: 54 TISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQI 112
++ K+ + KE+S+ I L KL + ++ L+ + + L ET L +QI
Sbjct: 558 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 617
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ + ++ + + ++N DS + K E++ L +I E + + ++D K
Sbjct: 618 EKMRLDYQHEIENLQNQQDSERAAHAK--EMEALRAKLMKVIKEKENSLEAIRSKLD--K 673
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNIC-AQCKLKENLIQSLHIGYDNTLSKL-NRSI 230
++ L + L KL E+E K+ + A+C + +I + T KL +
Sbjct: 674 AEDQHLVEMEDTLNKL-QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 732
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKEL-------CEDFTSIKNHLELHEPNMTMDLDE 283
+S +++ L+ +L+A + K L +SI L+ E +T +L E
Sbjct: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT-NLQE 791
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
L E ++ + K + +K SE+ ++ + + ++ +++ + +F
Sbjct: 792 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ-RSMQETVNKLHQK-----EEQFNML 845
Query: 344 SLDVFEILMDNIIN---KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
S D+ E L +N+ + K++ + DE E+ K + L +E+ K++ NS +
Sbjct: 846 SSDL-EKLRENLADMEAKFR-EKDEREEQLIKAKEKLENDIAEIM----KMSGDNSSQLT 899
Query: 401 KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLP 460
K N + LR+++ + E+ +T K NE L K + + + + +
Sbjct: 900 KMN--DELRLKERDVEELQLKLT-----KANENASFLQKS---IEDMTVKAEQSQQEAAK 949
Query: 461 AHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
H++ + EL R ++EK ++ET + E
Sbjct: 950 KHEE---------EKKELERKLSDLEK---KMETSHNQCQELKARYERATSETKTKHEEI 997
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
N K+L + KL K +EN+ L ++ L ++ + K A E+ M + + +
Sbjct: 998 LQNLQKTLLDTEDKL-KGAREENSGLLQELEELRKQAEKAKAAQTA-EDAMQIMEQMTKE 1055
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
TE ++++ K+ N L++ D + EL +S +++ ++++ + +I
Sbjct: 1056 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1115
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQ------NLALKEQCEEKTRDCSRLEINIKTHE-KTA 693
+E L E+ + ++ EE+ + + +K E K
Sbjct: 1116 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1175
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ + LQK I L EK+ +L +L N+ L R +A+ K L S V L
Sbjct: 1176 KDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL-RGENASAKSLHS---VVQTLE 1231
Query: 754 TQKDLVEGRIAELESDIR 771
+ K +E ++ LE ++
Sbjct: 1232 SDKVKLELKVKNLELQLK 1249
Score = 68.9 bits (161), Expect = 9e-11
Identities = 166/921 (18%), Positives = 374/921 (40%), Gaps = 83/921 (9%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K +E L +++++ + T + E+++E + ++V E L ++D L+
Sbjct: 360 KQQHIEQLLAERDLERAEVAKATSH--VGEIEQELALARDGHDQHVLE---LEAKMDQLR 414
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
E ++ ++L + E + K+ Q +++E I + K +
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVED----LQFRVEEESITKGDLEVATVSEKSRIMELE 470
Query: 233 SNTSTRYNKICTLQSELD----AGREDCK-ELCEDFTSIKNHLEL----HEPNMTMDLDE 283
+ + R ++ L+ L+ AG D L ++ +S++ LE+ H+ +T L E
Sbjct: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT-SLKE 529
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEF 340
G E K +K + L+ +E L + + +K++ D I +K L + +
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH- 588
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
+++ ++ + + E+ + K++ D L++ + + +++ +E
Sbjct: 589 -QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEME 647
Query: 401 KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLP 460
A ++++ KE+ + + A+ + K E++ + KL + +I + ++L+
Sbjct: 648 ALRA-KLMKVIKEKENSLE-AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV-KELEVLQA 704
Query: 461 AHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+ T + D +Q + + ++ + LR + K+ LE
Sbjct: 705 KCNEQTKVIDNFTSQLKATEEKL-LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 521 AHNEVKSLHEELTK------LYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLS 573
N S +T+ L + + EN + ++ +K L +E+ LK A+ E+ +S
Sbjct: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
Query: 574 ----LSEKDNKLTELVSTINGLKEENNSLK-SLNDVITREKETQASELERSCQVIKQNGF 628
+ E NKL + N L + L+ +L D+ + +E ER Q+IK
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD----EREEQLIKAK-- 877
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA-LKEQCEEKTRDCSRLEINIK 687
+K++ DI DE + L E+++ L+ + + + S L+ +I+
Sbjct: 878 --EKLENDIAEIMKMSGDNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIE 934
Query: 688 THEKTAE-IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
AE Q + +++ +E ++ + E K+ N+ + LK Y+ A + ++
Sbjct: 935 DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 994
Query: 747 EAVNQLTTQKDLV--EGRI--AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E + Q QK L+ E ++ A E+ ++ +
Sbjct: 995 EEILQ-NLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMT 1053
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-------RYKELD 855
E + + L+D+ + + + +E+ LKE L +EL+ KE + +E
Sbjct: 1054 KEKTETLAS--LEDTKQTNAKL--QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 856 DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV----- 910
E ET + ++ +Q + L++E + L +++ ++++ + Q +E + + +
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
Query: 911 -------NTDEDWANLHSVVVDRMSY----DAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ DE+ A+L + + DAE+EK + + + + L + V
Sbjct: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
Query: 960 MQKAMEKYTKKDKEFEAKRKE 980
++ K K K E + KE
Sbjct: 1230 LESDKVKLELKVKNLELQLKE 1250
Score = 65.7 bits (153), Expect = 9e-10
Identities = 155/769 (20%), Positives = 298/769 (38%), Gaps = 66/769 (8%)
Query: 28 DGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQ 87
+ KSK ++ + S+ I L S T Q+++E + L + E ++K Q
Sbjct: 557 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 616
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD-----KEIKNLTDSLKTKSKKINE 142
+ YQ+ I Q + + EME L KE +N +++++K K +
Sbjct: 617 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 676
Query: 143 --LQEENDTLSNLIMENV---------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVN- 190
L E DTL+ L + + + K +D+ + +K +DL+ L
Sbjct: 677 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 736
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
SE K K + Q + E I+ L I + N S +++ TR EL
Sbjct: 737 SSEGKSEMKKLRQQLEAAEKQIKHLEI-------EKNAESSKASSITR---------ELQ 780
Query: 251 AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
L E+ + + E E + + L EK E +E +AV V ++ +N L
Sbjct: 781 GRELKLTNLQENLSEVSQVKETLEKELQI-LKEKFAEASE---EAVSVQRSMQETVNKLH 836
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
++ + +++ +++ LA ++A+F D E + K + D+ EI++
Sbjct: 837 QK--EEQFNMLSSDLEKLREN-LADMEAKF--REKDEREEQLIKAKEKLENDIAEIMKMS 891
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L + EL+ + L +L + + L+ E + + + KK
Sbjct: 892 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPA-HKKIT----ILFDALITQYELSRTDYEI 485
E K+ L ++ L K K++ + Q+L A +++ T + ++ + + D E
Sbjct: 952 EEEKKELERKLSDLEK-KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE- 1009
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+K K E + T E+A ++ + +E T+ S D
Sbjct: 1010 DKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNSLKSL 601
N L E+D LK KN E++ L+ ++ K+ E I LK+
Sbjct: 1070 NAK----LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1125
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ E A EL RS + + +L++ ++ + DE K+
Sbjct: 1126 LSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1184
Query: 662 LEQNLALKEQ-CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
L++++++ EK + +L E+ + E + ++ Q E DK+ +E +
Sbjct: 1185 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV----QTLESDKVKLELK 1240
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
K EL K + + D ++ + Q +Q D + I +L+
Sbjct: 1241 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQ-ESQIDFLNSVIVDLQ 1288
Score = 64.5 bits (150), Expect = 2e-09
Identities = 124/613 (20%), Positives = 266/613 (43%), Gaps = 59/613 (9%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R++LD K+++ +++E + KLQ++ I K + L+ NE ++ + +L
Sbjct: 668 RSKLD--KAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFTSQLKA 722
Query: 84 IKEQ--------KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
+E+ K++ EGK + L Q + QIK LE+E + + ++T L+
Sbjct: 723 TEEKLLDLDALRKASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAESSKASSITRELQG 781
Query: 136 KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ K+ LQE +S + + L KE+ LK+ +++ + +++ + E+ NK
Sbjct: 782 RELKLTNLQENLSEVSQV-------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 834
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ K + + N++ S L KL +++D ++ + + +L +E
Sbjct: 835 LHQK------EEQFNMLSS-------DLEKLRENLAD--MEAKFREKDEREEQLIKAKEK 879
Query: 256 CKELCEDFTSIK--NHLELHEPNMTMDLDEKLGENNEFE-TKAVKVMSEIKRNLNSLSEQ 312
+ + + N +L + N + L E+ E + + TKA + S +++++ ++ +
Sbjct: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
Query: 313 LINNESKKSKDHIDRYK--DSLLAVLDAEFGTTSLDVFEI--LMDNIINKYQIDLDEILE 368
++ + +K H + K + L+ L+ + T+ E+ + ++ + +EIL+
Sbjct: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
+Q L + +LK E+ + L +L E + + + E + + + K
Sbjct: 1000 ---NLQKTLLDTEDKLKGAREENSGLLQELEELRKQAE--KAKAAQTAEDAMQIMEQMTK 1054
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
++ E L +KL+ ++ + +L +++ + L + + E KE
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME---EFRKE 1111
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS---LHEELTKLYKSKVDENNA 545
L+ A+ + L + +EV S L EE + L ++
Sbjct: 1112 IETLKQAAAQK-SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1170
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
IK EE +L+ +I+ L+EKD +L +L + + L+ EN S KSL+ V+
Sbjct: 1171 ESKFIKDADEEKASLQKSISITS---ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV 1227
Query: 606 -TREKETQASELE 617
T E + EL+
Sbjct: 1228 QTLESDKVKLELK 1240
Score = 43.6 bits (98), Expect = 0.004
Identities = 78/455 (17%), Positives = 194/455 (42%), Gaps = 35/455 (7%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+ L ++N +LK + E ++ S + K+ +TA ++ M + ++ L E
Sbjct: 550 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME-ELKVSFSKGLGTET- 607
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATV 778
+ EL + E ++ DY +++L++ +++ ++ +E A+L I+ ++ +
Sbjct: 608 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE--MEALRAKLMKVIKEKENSLE 665
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK---E 835
E + ++ + + + D+ SQLK E
Sbjct: 666 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 725
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
+LL +LD L++ E E + + L+ ++Q L+ EK + + S++ +++
Sbjct: 726 KLL----DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
R+ K ++ N E V ++ +EK +++K E+ ++ +
Sbjct: 782 -----RELKLTNLQENLSE---------VSQVK--ETLEKELQILK--EKFAEASEEAVS 823
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
MQ+ + K +K+++F +LE + L +++ +++E DE E + ++ E
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
Query: 1016 -CKRLKEAKIALEIVDKLSNQKVALEKQIE--SLSNTPVSNSTMYVATG---SAIVQNQQ 1069
+ +K + + K++++ E+ +E L T + + ++ + Q
Sbjct: 884 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 943
Query: 1070 ITDVMKENQKLKKMNAKLITICKKRGKTGANRENE 1104
+ K++++ KK + ++ +K+ +T N+ E
Sbjct: 944 QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 978
Score = 37.9 bits (84), Expect = 0.20
Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 10/148 (6%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY 95
+++ Q +K ++S I + + SL++S + + L + EL ++ + + L G
Sbjct: 1158 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG-- 1215
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
E + L S +++LE + + + ++KNL LK ++++ DT ++
Sbjct: 1216 -----ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQAD-ED 1269
Query: 156 ENVTES--DNLNKEVDDLKKNNECLTQK 181
E ES D LN + DL++ N+ L K
Sbjct: 1270 ERAQESQIDFLNSVIVDLQRKNQDLKMK 1297
>AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein.
Length = 1870
Score = 76.2 bits (179), Expect = 6e-13
Identities = 195/1040 (18%), Positives = 421/1040 (40%), Gaps = 97/1040 (9%)
Query: 74 LEKLSGELFDIKEQKSA-LEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK--EIKNLT 130
+E++ G FD K +A ++ N + + ++ + ++E L K+ +K L
Sbjct: 142 IERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLI 201
Query: 131 DSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVN 190
D S+ I EL EE D L L + + ++ + L+ + D + +
Sbjct: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261
Query: 191 ESENKIGPKNI-CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
++ K CK + ++ + I + +SD+ ++ Y + EL
Sbjct: 262 RLRQELEEKTEQLLDCKQE---LEQMEIELKRLQQENMNLLSDARSARMY------RDEL 312
Query: 250 DAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNS 308
DA RE + + + + + E LH+ E+L E+N+ V+ E K
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ-------VLLETK---TM 362
Query: 309 LSEQLINNESKKSKDH-IDRYKDSLLAVL---DAEFGTTSLDVFEILMDNIINKYQIDLD 364
L +QL ++ K H +++ L A L + E + E++ +N+ ++
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT--LEMAQK 420
Query: 365 EILEKYTKVQGDLNEC--TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
+ +++ + +L + TSEL +K SL ++ E ++ R+ K + S
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQK--SLGHEVNELTSS----RLLKLEMENQSLTK 474
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
T++ ++ + E + LK+ K ++ KK+ IL + ++ + + +
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEK----------ENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD- 541
+ K+ ++ + K + E + V SL + +++V
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 542 ---ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
EN IK S ++ ++ + ++++ EK + EL + ++ L++EN L
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644
Query: 599 --KSLNDVITREK----ETQASELERSCQVIKQN-------GFELDKMKADILMXXXXXX 645
K N IT EK E + SELER + +K+ F+L+ ++ +
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ------NRM 699
+ + + L KE EK + LE+ + +KT ++ +
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
RLQK ++ +K + E++L +L + + L+++ +++L+ S + + QL + +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN----LEELKISSKRLEQLEKENKSL 820
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN-------- 811
E ++LE D + + EN+ L +
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC 880
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
+L + K + ++ + + + L++ +++L K + ++++++ E L++
Sbjct: 881 VRLKELEKENKELVKRATIDI--KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK---- 934
Query: 872 CARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L KE+L ++Q ++ + ++ + K ++ +E A L + + + +Y+
Sbjct: 935 -IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK---EEKIAALEARLEESTNYNQ 990
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
++ + + +K E ++QD + V + K ++E + +EL K L E+
Sbjct: 991 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEKQIESLSNTP 1050
++ L E + LKQ E Q L+ +AL+ L Q L+ Q L
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ--- 1107
Query: 1051 VSNSTMYVATGSAIVQNQQI 1070
V NST+ + S + QN Q+
Sbjct: 1108 VENSTLNSQSTSLMNQNAQL 1127
Score = 75.4 bits (177), Expect = 1e-12
Identities = 231/1086 (21%), Positives = 438/1086 (40%), Gaps = 112/1086 (10%)
Query: 41 QSNPIKLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEG-KYQ 96
Q N L D+ + + +L+E + +++ ++ + L DI+ K+ +E K
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 97 N-LILETQT--RDLL------MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEEN 147
N ++LET+T D L ++ LE ENL ++ ++ KKI EL EEN
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 148 DTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKL 207
TL +++ ES +L E++ + + +E L VNE + K L
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 208 KENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGRE---DCKELCEDF 263
+ ++ L D+ ++ + + R +K + L++E+ ++ +C+ L +D
Sbjct: 473 TKT-VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 264 TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKD 323
K LE T+ E L EN+E + +K++ + +LN L ++
Sbjct: 532 MKEKAQLE-----KTI---ETLRENSE---RQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 324 HI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNECT 381
+ D K++ +L TS + +I + K +++ E E+ +++ +L+
Sbjct: 581 RVKDIEKEN--KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
E + + +K+ +L EK A + ER + T+D K E L KE
Sbjct: 639 KENELLQKKITNLKITC-EKIEALEQENSELERENR-KLKKTLDSFKNLTFQLESLEKEN 696
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLETGTAKA 499
+L + +++ R+++ A K+ L + EL +++K E L+ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQL---QLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDA 559
+ TLE ++ +++ L EL L + + NL +KI S+ ++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLEQ 812
Query: 560 LKIAIAKNEEKMLSLS------EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
L+ E++ L EK+NK + I E N++K N + +E +T +
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN--LEKENKTLS 870
Query: 614 SEL---ERSCQVIKQ---NGFELDK-----MKADILMXXXXXXXXXXXXXXXXDEAKSLL 662
E+ + SC +K+ EL K +K + + D K
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 663 E-QNLAL-KEQC---EEKTRDCSRL-EINIK-THEKTAEIQNRMIMRLQKQIQEDDKLFI 715
E + + L KE+ E+ T D +L E ++ T +K+ EI+ I L+ +++E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 990
Query: 716 EKETKLNELTNKYEALKRDYDAA--------VKDLESSREAVNQLTTQKDL-VEGRIAEL 766
+ +L + YEALK+ D + ++ E +Q TT++ L V+ R+ E+
Sbjct: 991 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
E + T Q + L E + + V
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV-- 1108
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK--EKLSL-- 882
E S L + S + L + L++E E+ + ++ L K EKL L
Sbjct: 1109 --ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1166
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL---HSVVVDRMSYDAEVEKNKRL 939
E+Q S + I ++ K +V ED N ++ + +VE+ K L
Sbjct: 1167 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML 1226
Query: 940 M--KTIEEL--RYKK-----QDLKNTVTKMQKAMEKYTKKDKEFEA--KRKELEDCK--A 986
+ K E + YKK L +T +++ K E K ++ +LE + A
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1286
Query: 987 ELEELKQRYKELD-------EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL 1039
E +LK++Y++LD +CE ++ EE+ + L + +I + + L
Sbjct: 1287 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD-----QIQTLMLQNRTLL 1341
Query: 1040 EKQIES 1045
E+ +ES
Sbjct: 1342 EQNMES 1347
Score = 68.1 bits (159), Expect = 2e-10
Identities = 143/791 (18%), Positives = 340/791 (42%), Gaps = 58/791 (7%)
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVN---EKLASLNSQLIEKENACNILRIQKERIHEI 418
+L+++ + ++Q + S+ +S ++L +L + + + + + KER+H+I
Sbjct: 280 ELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDI 339
Query: 419 SS-AVTIDIVKKENEL---KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
++ +K++N++ + + ++ L+ ++ + D +L+++ + ++ +
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---NLQLKAKLHDMEM 396
Query: 475 QYELSRTDYE-IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
+ ++ R E + +E + LE +++ T E + KSL E+
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVN 455
Query: 534 KLYKSKVDE-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTI-NGL 591
+L S++ + N +L K + EE+ ++ N K+L + +++ +L++ V + N +
Sbjct: 456 ELTSSRLLKLEMENQSLTKTV-EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+E SL++ + ++++ + ++LE++ + +++N K+
Sbjct: 515 VQEKQSLQNCQN-LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
Query: 652 XXXXDEA--KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK---- 705
EA K + ++N L E +E + S++E + +K E R ++
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 706 --QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD---LESSREAVNQLTTQKDLVE 760
++++++L +K T L K EAL+++ ++ L+ + ++ LT Q + +E
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
++L+ + E V + ++ + E K
Sbjct: 694 KENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 821 SISVIS---DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE---RDEQCAR 874
+ V D E +L++ L + +++ L+ ++L+ E +T + L+E ++ +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 875 LKKEKLSLEQQVSNL---KEQIRTQQP-VERQAKFADVAV--------NTDEDWANLHS- 921
L+KE SLEQ+ S L K+Q+ + + +QA+ D + N +++ L
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 922 --VVVDRMSYDAEVEK-NKRLMKT----IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
+ + E+EK NK L+K I+ L ++DL + K Q+ K E
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECE-TCAEYLKQREEQCKRLKEAKI--ALEIVDK 1031
E E + + RYK L+ + E T + L+ +EE+ L EA++ + +
Sbjct: 933 EKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL-EARLEESTNYNQQ 991
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITIC 1091
L + ++K E+L + + + N+ + + ++L K+ +LI +
Sbjct: 992 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1051
Query: 1092 KKRGKTGANRE 1102
+ A ++
Sbjct: 1052 RNNATLQAEKQ 1062
Score = 62.9 bits (146), Expect = 6e-09
Identities = 99/590 (16%), Positives = 247/590 (41%), Gaps = 49/590 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLI------KILSEEIDALKIAIAKNEEKM 571
LEE ++ +EL ++ N+NL+ ++ +E+DAL+ + ++
Sbjct: 267 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK-- 324
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
L + ++ E + I K LK N V+ K +LE + + +L
Sbjct: 325 --LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT----RARSDKLH 378
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
+++ + L + + L+E+N+ L+ ++ + L ++ +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 692 TAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
T+E+ L ++ E ++ E + LT E L+ D+ +E + +
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS----VEGNASKIL 494
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
++ + + ++ LE++I E+ + T
Sbjct: 495 KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET---------- 544
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-RYKELDDECETCAEYLQERD 869
L ++ +R I ++ + E L + + S +Q E R K+++ E + E ++E
Sbjct: 545 ---LRENSERQIKIL-EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ ++++ EK +++++ + KE+ + +E + + + + +++
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-- 658
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA--- 986
+A ++N L + +L+ KN +++ ++ ++ D+E R+ +E K
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV--ALE---- 1040
++ +L+ KEL+ E E + L+ + K+ + +++ + +D + NQ++ LE
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD-IENQRLQKTLENSNK 777
Query: 1041 --KQIES-LSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+Q+ES L + + N T+ + ++++ + KEN+ L++ ++L
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Score = 59.7 bits (138), Expect = 6e-08
Identities = 111/580 (19%), Positives = 227/580 (39%), Gaps = 30/580 (5%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + +++ L + + K +DE + + I LSEE D L +
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCG 236
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K TE + L E K+ + +E E + +L Q ++Q EL +++
Sbjct: 237 SPGMKRTE---SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINI-KTHEKTA 693
+ + DE +L E+ + + + E +R RL +I K +
Sbjct: 294 ENM----NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ N++++ + +++ + + KL+EL + LK A + D+E R+ +
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK----AKLHDMEMERDMDRKKI 405
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
++L+E + LE + ++ + G E +L +
Sbjct: 406 --EELMEENMT-LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 814 L-----DDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
L + S +++ + + V ++L ++E L ++ + L++E + LQ
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ 522
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
L KEK LE+ + L+E Q + Q + T + +
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEA 580
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA 986
D E E NK L ++I+E K ++ +++K +E Y +K + E EL +
Sbjct: 581 RVKDIEKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
E E L+++ L CE ++ E + ++ K L+ L+ Q +LEK+ L
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 1047 --SNTPVSNSTMYVATGSAIVQNQQI--TDVMKENQKLKK 1082
N + + + S + Q+ ++ E ++LKK
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 739
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 819 KRSISVISDSEVSQLKERLLSCQ---QELDDLKERYKELD-DECETCAEYLQE---RDEQ 871
K S EV +L LL C Q+ ++ ER + LD D A ++QE E
Sbjct: 110 KNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN 169
Query: 872 CARLKKEK---LSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
L+ + +S E LK + ++ ++ + + ++ + E+ LH +
Sbjct: 170 VFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHA 227
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S A+ MK E ++ +L + K+++ + E E K ++L DCK E
Sbjct: 228 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQ-------ELEEKTEQLLDCKQE 280
Query: 988 LEELKQRYKELDEE 1001
LE+++ K L +E
Sbjct: 281 LEQMEIELKRLQQE 294
>U93121-1|AAB88727.1| 753|Homo sapiens M-phase phosphoprotein-1
protein.
Length = 753
Score = 75.8 bits (178), Expect = 8e-13
Identities = 85/372 (22%), Positives = 165/372 (44%), Gaps = 25/372 (6%)
Query: 671 QCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA 730
Q EE + +L+ +K ++ + NR+ +K+ + D L EKET + +L + +
Sbjct: 10 QIEELEQQIEKLQAEVKGYK---DENNRL---KEKEHKNQDDLLKEKETLIQQLKEELQE 63
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRT---EQTATVXXXXXXXXX 787
D ++ + + A+++LT + +I ELE+ + T E++ +
Sbjct: 64 KNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVERSHSAKLEQDILEK 123
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
F + +D +N K D + + + E++QL L + L L
Sbjct: 124 ESIILKLERNLKEFQEHLQDSVKNTK--DLNVKELKL--KEEITQLTNNLQDMKHLLQ-L 178
Query: 848 KERYKELD-DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA 906
KE +E + E E E L + LK + E+ ++LKE++ + +Q +
Sbjct: 179 KEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQ-K 237
Query: 907 DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAM 964
+V+V DED L + ++ + + MK TI++L K+ L N K+++A+
Sbjct: 238 EVSVMRDED--KLLRIKINELEKKKNQCSQELDMKQRTIQQL---KEQLNNQ--KVEEAI 290
Query: 965 EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
++Y + K+ K K +ED + LEE +Q E D+ E E +++ + ++ KE
Sbjct: 291 QQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCN 350
Query: 1025 ALEIVDKLSNQK 1036
LE + + K
Sbjct: 351 DLETKNNQRSNK 362
Score = 69.3 bits (162), Expect = 7e-11
Identities = 105/505 (20%), Positives = 215/505 (42%), Gaps = 48/505 (9%)
Query: 564 IAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
+ + +K + E + ++ +L + + G K+ENN LK +E + Q L+ +I
Sbjct: 1 VKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKE------KEHKNQDDLLKEKETLI 54
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
+Q EL + + + + + ++E AL E + T C + +
Sbjct: 55 QQLKEELQEKNVTLDV-----------------QIQHVVEGKRALSELTQGVT--CYKAK 95
Query: 684 I-NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL-TNKYEALKRDYDAAVKD 741
I ++T +T +++ +L++ I E + + ++ E L E + +++K D VK+
Sbjct: 96 IKELETILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKE 155
Query: 742 L---ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXX 798
L E + N L K L++ + E E++ + +
Sbjct: 156 LKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKE 215
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSE------VSQLKERLLSCQQELDDLKERYK 852
+ D L + K ++ +SV+ D + +++L+++ C QELD + +
Sbjct: 216 EDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQ 275
Query: 853 ELDDEC--ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
+L ++ + E +Q+ + C L ++ +E L+EQ +TQ VE Q + + +
Sbjct: 276 QLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQ--VE-QDQVLEAKL 332
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKK 970
E A ++ + D E + N+R K E L N ++Q++ +KY
Sbjct: 333 EEVERLATELEKWKEKCN-DLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNAD 391
Query: 971 DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ---CKRLKEAKIALE 1027
K++ ++ L E E + R KE+ + E + KQ+ E +L E L+
Sbjct: 392 RKKWLEEKMMLITQAKEAENI--RNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQ 449
Query: 1028 IVDKLSNQKV-ALEKQIESLSNTPV 1051
+ +Q V ALE Q+++L ++ V
Sbjct: 450 KWREERDQLVAALEIQLKALISSNV 474
Score = 49.6 bits (113), Expect = 6e-05
Identities = 82/375 (21%), Positives = 175/375 (46%), Gaps = 41/375 (10%)
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMEN-LTKDKEIKNLTDSLKTKSKKI----NE 142
K++ + +Q LE Q + L +++K + EN K+KE KN D LK K I E
Sbjct: 2 KASSKKSHQIEELEQQI-EKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEE 60
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
LQE+N TL ++ +++V E + + +L + C K +LE ++ K+ +
Sbjct: 61 LQEKNVTL-DVQIQHVVEG---KRALSELTQGVTCYKAKIKELETIL--ETQKVERSH-- 112
Query: 203 AQCKLKENLI--QSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELC 260
KL+++++ +S+ + + L + + DS +T+ D ++ K L
Sbjct: 113 -SAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK-----------DLNVKELK-LK 159
Query: 261 EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKK 320
E+ T + N+L+ + + L E+ E N ET+ K+ E+ + ++ ++ L + +K
Sbjct: 160 EEITQLTNNLQ--DMKHLLQLKEEEEETNRQETE--KLKEELSAS-SARTQNLKADLQRK 214
Query: 321 SKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+D+ D K+ L DA+ + +M + +I ++E+ +K + +L+
Sbjct: 215 EEDYAD-LKEKL---TDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMK 270
Query: 381 TSELKSVNEKL--ASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILT 438
++ + E+L + + + E AC L + KE+I E + + + E ++L
Sbjct: 271 QRTIQQLKEQLNNQKVEEAIQQYERACKDLNV-KEKIIEDMRMTLEEQEQTQVEQDQVLE 329
Query: 439 KECLKLSKLKIDIPR 453
+ ++ +L ++ +
Sbjct: 330 AKLEEVERLATELEK 344
Score = 47.2 bits (107), Expect = 3e-04
Identities = 95/522 (18%), Positives = 215/522 (41%), Gaps = 40/522 (7%)
Query: 133 LKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNES 192
+K SKK ++++E + L E D N+ + KN + L + + E L+ +
Sbjct: 1 VKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLK---EKETLIQQL 57
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ ++ KN+ ++ +++++ LS+L + + + + ++ T+
Sbjct: 58 KEELQEKNVTLDVQI-QHVVEG-----KRALSELTQGV--TCYKAKIKELETILETQKVE 109
Query: 253 REDCKELCEDF---TSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
R +L +D SI LE + L + + + K +K+ EI + N+L
Sbjct: 110 RSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNL 169
Query: 310 SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + K+ ++ +R + L E +S + D + + + D ++ EK
Sbjct: 170 QDMKHLLQLKEEEEETNRQETE---KLKEELSASSARTQNLKAD--LQRKEEDYADLKEK 224
Query: 370 YTKVQGDLNECTSELKSV--NEKLASLN-SQLIEKENACN-ILRIQKERIHEISSAVTID 425
T + + + E+ + +KL + ++L +K+N C+ L +++ I ++ +
Sbjct: 225 LTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQ 284
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
V++ + E K+ K+ D+ L++ + + +A + + E T+ E
Sbjct: 285 KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEK 344
Query: 486 EKEKLR-LETGT---AKAVXXXXXXXXXXXXXXFDTLEEAHNEV-----KSLHEELTKLY 536
KEK LET + D L+E+ + K L E++ +
Sbjct: 345 WKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLIT 404
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
++K EN N + K + K +NE ++L+ +LTE S + +EE +
Sbjct: 405 QAKEAENIRNKEMKKYAEDRERFFK---QQNEMEILTA-----QLTEKDSDLQKWREERD 456
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
L + ++ + + + + + +K+ E K++ I+
Sbjct: 457 QLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIM 498
Score = 43.6 bits (98), Expect = 0.004
Identities = 74/350 (21%), Positives = 161/350 (46%), Gaps = 40/350 (11%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
LKE E N + E +KE+ SA + QNL + Q ++ + +K E LT
Sbjct: 178 LKEEEEETNRQ------ETEKLKEELSASSARTQNLKADLQRKEEDYADLK----EKLTD 227
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
K+ +K K+++ +++E+ L I E + + ++E+D ++ + L ++
Sbjct: 228 AKK------QIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQ- 280
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
++ +K V E+ + + C +KE +I+ + + + + + D + ++
Sbjct: 281 LNNQK-VEEAIQQY--ERACKDLNVKEKIIEDMRMTLEE--QEQTQVEQDQVLEAKLEEV 335
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTM-----DLDEKLGENNEFETKAVK 297
L +EL+ +E C +L E + +++ E HE N + +L ++L E+ + K
Sbjct: 336 ERLATELEKWKEKCNDL-ETKNNQRSNKE-HENNTDVLGKLTNLQDELQESEQKYNADRK 393
Query: 298 VMSEIKRNLNSL---SEQLINNESKKSKDHIDRY--KDSLLAVLDAEFGTTSLDV--FEI 350
E K L + +E + N E KK + +R+ + + + +L A+ D+ +
Sbjct: 394 KWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWRE 453
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
D ++ +I L ++ + VQ D NE +LK + + + + +Q+++
Sbjct: 454 ERDQLVAALEIQLKALIS--SNVQKD-NE-IEQLKRIISETSKIETQIMD 499
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 334 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 391
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 392 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 451
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 452 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 505
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 506 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 559
>X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa
protein.
Length = 976
Score = 75.4 bits (177), Expect = 1e-12
Identities = 132/616 (21%), Positives = 266/616 (43%), Gaps = 52/616 (8%)
Query: 69 EINLKLEKLSGEL-FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK 127
E+ ++ E E+ F +KE ++ Q E ++ Q+ L ++ K+ ++K
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE---KQVSLLLIQITEKENKMK 283
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
+LT L+ K+N+L+E+ S + +++ + +L KE++D+K + Q+ + +K
Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS----LQRSVSTQK 339
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
+ E + +I K IC + KE ++ ++ ++ S + T +C+L+
Sbjct: 340 AL-EEDLQIATKTICQLTEEKETQME------ESNKARAAHSFVVTEFET---TVCSLE- 388
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
EL + E ED I +EL + + ++ KL N E E + +K + K L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILT-MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL- 446
Query: 308 SLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL 367
L E N + +K + + + L+ +L A + EI + I Q E+
Sbjct: 447 -LYE---NKQFEKIAEELKGTEQELIGLLQAR--EKEVHDLEIQLTAITTSEQYYSKEVK 500
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSAVTIDI 426
+ T+++ + + T EL S KL+ N +L ++ + + L+ Q+E I+ + +
Sbjct: 501 DLKTELENEKLKNT-ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERM 558
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ L+E T+ +L ++ ++ + D+ K + L Q E ++ Y
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVE-NKNKY--- 614
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
E+L+ E K + LE K E+T Y+ ++++ +
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 547 LNLIKILSEEIDALKIAIAKNEEKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDV 604
+ L EE++ K+ IA K+ +K +K+ E+V+ + K + + + D
Sbjct: 675 ---EENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
Query: 605 ---ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ + KE + S L S ++ EL +KA++L EAK
Sbjct: 731 ELGLYKSKEQEQSSLRASLEI------ELSNLKAELLSVKKQLEIEREEKEKLKREAK-- 782
Query: 662 LEQNLALKEQCEEKTR 677
E LKE+ ++KT+
Sbjct: 783 -ENTATLKEKKDKKTQ 797
Score = 56.8 bits (131), Expect = 4e-07
Identities = 109/536 (20%), Positives = 221/536 (41%), Gaps = 56/536 (10%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLS 575
L+E + +++ L +E K K E +L LI+I +E + L + ++ +K+ L
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDK--EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDV---ITREKETQASELERSCQVIKQNGFELDK 632
EK +E + ++++++ K L D+ + R TQ + LE Q+ + +L +
Sbjct: 301 EKTKLQSENLK--QSIEKQHHLTKELEDIKVSLQRSVSTQKA-LEEDLQIATKTICQLTE 357
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
K + + LE+ L ++Q EK D +L+I T
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED--QLKI------LT 409
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E+Q + +++E KL KE +L EL K K K E E +
Sbjct: 410 MELQKK-----SSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKG- 462
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T+++L+ G + E ++ + + E +DL
Sbjct: 463 -TEQELI-GLLQAREKEVHDLEIQLTAITTSEQY--------------YSKEVKDL--KT 504
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L++ ++ + S L+ + L+ QE D+ K ++ + + +Q
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELT--QETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
L++ + L ++ ++E+++ Q+ E + K ++E+ NL V ++ Y E
Sbjct: 563 ENLQETETQLRNELEYVREELK-QKRDEVKCKLD----KSEENCNNLRKQVENKNKYIEE 617
Query: 933 VEK-NKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAEL 988
+++ NK L K T E + ++K V K++ +E +K E + +KE+ED K
Sbjct: 618 LQQENKALKKKGTAESKQLNVYEIK--VNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
E L + ++ + + K+ +++C+ +AL K K+ E+ E
Sbjct: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSE 731
Score = 50.8 bits (116), Expect = 3e-05
Identities = 61/268 (22%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
++++ + ++ L++ +++ +L+++ + +E L++ E+ L KE LE +
Sbjct: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE---LEDIKVS 330
Query: 889 LKEQIRTQQPVERQAKFADVAVN--TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + TQ+ +E + A + T+E + R ++ V + + + ++EEL
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 947 -RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
R ++Q L+ +++ + KK E E K + + ELEELK K L E+ ET
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK---KVLGEK-ETL 446
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
KQ E+ + LK + E++ L A EK++ L + T S
Sbjct: 447 LYENKQFEKIAEELKGTE--QELIGLLQ----AREKEVHDL------EIQLTAITTSEQY 494
Query: 1066 QNQQITDVMKENQKLKKMNAKLITICKK 1093
++++ D+ E + K N +L + C K
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNK 522
Score = 48.4 bits (110), Expect = 1e-04
Identities = 94/515 (18%), Positives = 223/515 (43%), Gaps = 44/515 (8%)
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDAL-KIAIAKNEEKMLSLS 575
++E+ H+ K L + L +S V A ++I ++ I L + + EE + +
Sbjct: 313 SIEKQHHLTKELEDIKVSLQRS-VSTQKALEEDLQIATKTICQLTEEKETQMEESNKARA 371
Query: 576 EKDNKLTELVSTINGLKE----ENNSLKSLND---VITREKETQASELERSCQVIKQNGF 628
+TE +T+ L+E E L+ D ++T E + ++SELE ++
Sbjct: 372 AHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEV 431
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
EL+++K +L +E K ++ + L + E++ D LEI +
Sbjct: 432 ELEELK-KVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHD---LEIQLTA 487
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
+ + ++ + L+ +++ + E + N+L+ + + L ++ +L++ +E
Sbjct: 488 ITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQED 547
Query: 749 VNQLTTQKDLVEGRI---AELESDIRTE-----QTATVXXXXXXXXXXXXXXXXXXXXXT 800
+N Q++ + +I E E+ +R E +
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 801 FGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
++N+ + E + + + K+ +++ + ++ + EL+ K+++ E+ D
Sbjct: 608 VENKNKYIEELQQENKALKKK-GTAESKQLNVYEIKVNKLELELESAKQKFGEITD---- 662
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNL--KEQIRTQQPVER--QAKFADVAVNTDEDW 916
Y +E +++ ++ +E L E + + + E ++ Q+ +++ Q K A++ ++
Sbjct: 663 --TYQKEIEDK--KISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHK 718
Query: 917 ANLHSVVVDRMS----YDAEVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQ---KAMEKYT 968
++ +R S Y ++ ++ L ++E EL K +L + +++ + EK
Sbjct: 719 HQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLK 778
Query: 969 KKDKEFEAKRKELEDCKAE--LEELKQRYKELDEE 1001
++ KE A KE +D K + L E + Y +LD +
Sbjct: 779 REAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Score = 47.2 bits (107), Expect = 3e-04
Identities = 124/576 (21%), Positives = 250/576 (43%), Gaps = 60/576 (10%)
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+SK+ EN KI+ + A++ NE+ L L E + +L+ +ENN
Sbjct: 131 ESKLQENR------KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI-------KENN 177
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + L +++ KET A RS + K+ +E ++ + +
Sbjct: 178 ATRHLCNLL---KETCA----RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAHGELRV 230
Query: 657 EAK-SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+A+ S LE + LKE EK + + E + ++K ++ +I +K+ + D F+
Sbjct: 231 QAENSRLEMHFKLKED-YEKIQHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 716 --EKETKLNELTNK----YEALKRDYDA---AVKDLESSREAVNQ-LTTQKDLVEG-RIA 764
E K+N+L K E LK+ + K+LE + ++ + ++TQK L E +IA
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD--DSPKRSI 822
TE+ T E E +L+ + + +
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 823 SVISDSEVSQLKE--RLLSCQQ-ELDDLKERYKELD------DECETCAEYLQERDEQCA 873
++ + S+L+E +L + ++ EL++LK+ E + + E AE L+ +++
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L + + E++V +L+ Q+ E+ + T+ + L + + +
Sbjct: 469 GLLQAR---EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 934 EKNKRLMKTIE---ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELE 989
E + +T + EL+ +++D+ N K ++ M K + +E E + R ELE + EL+
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNN-KKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 990 ELKQRYK-ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + K +LD+ E C KQ E + K ++E L+ +K +K E + L+
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAES--KQLNV 638
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ + + + SA + +ITD ++ + KK++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Score = 41.5 bits (93), Expect = 0.016
Identities = 81/437 (18%), Positives = 169/437 (38%), Gaps = 39/437 (8%)
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN----ILRIQKERIHEISS 420
++ E Y K+Q E E+ ++++ L Q+ EKEN +L +++++++
Sbjct: 242 KLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE 301
Query: 421 AVTI--DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL 478
+ + +K+ E + LTKE L +K+ + R + + + I + E
Sbjct: 302 KTKLQSENLKQSIEKQHHLTKE---LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
T E + + LE+ +++K L EL K S
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKK-SS 417
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
+++E N ++ E++ LK + + E +L ++ + ++ + G ++E L
Sbjct: 418 ELEEMTKLTNNKEV---ELEELKKVLGEKE----TLLYENKQFEKIAEELKGTEQELIGL 470
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDE 657
+ + E Q + + S Q + +L +++ + L +
Sbjct: 471 LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKEL 530
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQ------KQIQEDD 711
+ + L LK Q E+ + + E +K E E + ++ L+ KQ +++
Sbjct: 531 TQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEV 590
Query: 712 KLFIEK-ETKLNELT------NKY--------EALKRDYDAAVKDLESSREAVNQLTTQK 756
K ++K E N L NKY +ALK+ A K L VN+L +
Sbjct: 591 KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
Query: 757 DLVEGRIAELESDIRTE 773
+ + + E+ + E
Sbjct: 651 ESAKQKFGEITDTYQKE 667
Score = 40.7 bits (91), Expect = 0.028
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 24/274 (8%)
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
V +++E+ Q + +L ++ ++ ++ +EL E + L+E ++ L KE +
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLM 940
+ LKE + E+ K+ T + + +L++ + ++ E+ +N RL
Sbjct: 181 HLCNLLKETCA--RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAHGELRVQAENSRL- 237
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
E+ +K LK K+Q ++Y K E K K++ ++ E + + K+L
Sbjct: 238 ----EMHFK---LKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 1001 ECETCAEYLKQREEQCKRLKE-AKIALE----IVDKLSNQKVALEKQIESLSNTPVSNST 1055
E + + Q EE+ K E K ++E + +L + KV+L++ S+S
Sbjct: 288 LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR---SVSTQKALEED 344
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ +AT + ++ M+E+ K + ++ ++T
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Score = 39.5 bits (88), Expect = 0.065
Identities = 65/272 (23%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTRDLL---MSQIKSLE 116
+ L + ++++ L+L+ ++ + K+Q+ + + +NL ETQ R+ L ++K
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 117 ME---NLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK---EVD 169
E L K +E NL ++ K+K I ELQ+EN L + ES LN +V+
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK---KGTAESKQLNVYEIKVN 644
Query: 170 DLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-L 226
L+ E QK ++ + + KI +N+ + + K +I + + K
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIADEAVKLQKEIDKRC 703
Query: 227 NRSISD-----SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD- 280
I++ +Y+KI + + + G KE ++ +S++ LE+ N+ +
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIE-ERDSELGLYKSKE--QEQSSLRASLEIELSNLKAEL 760
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
L K E E K K+ E K N +L E+
Sbjct: 761 LSVKKQLEIEREEKE-KLKREAKENTATLKEK 791
>BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 75.4 bits (177), Expect = 1e-12
Identities = 132/616 (21%), Positives = 266/616 (43%), Gaps = 52/616 (8%)
Query: 69 EINLKLEKLSGEL-FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK 127
E+ ++ E E+ F +KE ++ Q E ++ Q+ L ++ K+ ++K
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE---KQVSLLLIQITEKENKMK 283
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
+LT L+ K+N+L+E+ S + +++ + +L KE++D+K + Q+ + +K
Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS----LQRSVSTQK 339
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
+ E + +I K IC + KE ++ ++ ++ S + T +C+L+
Sbjct: 340 AL-EEDLQIATKTICQLTEEKETQME------ESNKARAAHSFVVTEFET---TVCSLE- 388
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
EL + E ED I +EL + + ++ KL N E E + +K + K L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILT-MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL- 446
Query: 308 SLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL 367
L E N + +K + + + L+ +L A + EI + I Q E+
Sbjct: 447 -LYE---NKQFEKIAEELKGTEQELIGLLQAR--EKEVHDLEIQLTAITTSEQYYSKEVK 500
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSAVTIDI 426
+ T+++ + + T EL S KL+ N +L ++ + + L+ Q+E I+ + +
Sbjct: 501 DLKTELENEKLKNT-ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERM 558
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ L+E T+ +L ++ ++ + D+ K + L Q E ++ Y
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVE-NKNKY--- 614
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
E+L+ E K + LE K E+T Y+ ++++ +
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 547 LNLIKILSEEIDALKIAIAKNEEKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDV 604
+ L EE++ K+ IA K+ +K +K+ E+V+ + K + + + D
Sbjct: 675 ---EENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
Query: 605 ---ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ + KE + S L S ++ EL +KA++L EAK
Sbjct: 731 ELGLYKSKEQEQSSLRASLEI------ELSNLKAELLSVKKQLEIEREEKEKLKREAK-- 782
Query: 662 LEQNLALKEQCEEKTR 677
E LKE+ ++KT+
Sbjct: 783 -ENTATLKEKKDKKTQ 797
Score = 56.8 bits (131), Expect = 4e-07
Identities = 109/536 (20%), Positives = 221/536 (41%), Gaps = 56/536 (10%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLS 575
L+E + +++ L +E K K E +L LI+I +E + L + ++ +K+ L
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDK--EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDV---ITREKETQASELERSCQVIKQNGFELDK 632
EK +E + ++++++ K L D+ + R TQ + LE Q+ + +L +
Sbjct: 301 EKTKLQSENLK--QSIEKQHHLTKELEDIKVSLQRSVSTQKA-LEEDLQIATKTICQLTE 357
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
K + + LE+ L ++Q EK D +L+I T
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED--QLKI------LT 409
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E+Q + +++E KL KE +L EL K K K E E +
Sbjct: 410 MELQKK-----SSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKG- 462
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T+++L+ G + E ++ + + E +DL
Sbjct: 463 -TEQELI-GLLQAREKEVHDLEIQLTAITTSEQY--------------YSKEVKDL--KT 504
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L++ ++ + S L+ + L+ QE D+ K ++ + + +Q
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELT--QETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
L++ + L ++ ++E+++ Q+ E + K ++E+ NL V ++ Y E
Sbjct: 563 ENLQETETQLRNELEYVREELK-QKRDEVKCKLD----KSEENCNNLRKQVENKNKYIEE 617
Query: 933 VEK-NKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAEL 988
+++ NK L K T E + ++K V K++ +E +K E + +KE+ED K
Sbjct: 618 LQQENKALKKKGTAESKQLNVYEIK--VNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
E L + ++ + + K+ +++C+ +AL K K+ E+ E
Sbjct: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSE 731
Score = 50.8 bits (116), Expect = 3e-05
Identities = 61/268 (22%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
++++ + ++ L++ +++ +L+++ + +E L++ E+ L KE LE +
Sbjct: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE---LEDIKVS 330
Query: 889 LKEQIRTQQPVERQAKFADVAVN--TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + TQ+ +E + A + T+E + R ++ V + + + ++EEL
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 947 -RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
R ++Q L+ +++ + KK E E K + + ELEELK K L E+ ET
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK---KVLGEK-ETL 446
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
KQ E+ + LK + E++ L A EK++ L + T S
Sbjct: 447 LYENKQFEKIAEELKGTE--QELIGLLQ----AREKEVHDL------EIQLTAITTSEQY 494
Query: 1066 QNQQITDVMKENQKLKKMNAKLITICKK 1093
++++ D+ E + K N +L + C K
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNK 522
Score = 47.2 bits (107), Expect = 3e-04
Identities = 124/576 (21%), Positives = 250/576 (43%), Gaps = 60/576 (10%)
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+SK+ EN KI+ + A++ NE+ L L E + +L+ +ENN
Sbjct: 131 ESKLQENR------KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI-------KENN 177
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + L +++ KET A RS + K+ +E ++ + +
Sbjct: 178 ATRHLCNLL---KETCA----RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
Query: 657 EAK-SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+A+ S LE + LKE EK + + E + ++K ++ +I +K+ + D F+
Sbjct: 231 QAENSRLEMHFKLKED-YEKIQHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 716 --EKETKLNELTNK----YEALKRDYDA---AVKDLESSREAVNQ-LTTQKDLVEG-RIA 764
E K+N+L K E LK+ + K+LE + ++ + ++TQK L E +IA
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD--DSPKRSI 822
TE+ T E E +L+ + + +
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 823 SVISDSEVSQLKE--RLLSCQQ-ELDDLKERYKELD------DECETCAEYLQERDEQCA 873
++ + S+L+E +L + ++ EL++LK+ E + + E AE L+ +++
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L + + E++V +L+ Q+ E+ + T+ + L + + +
Sbjct: 469 GLLQAR---EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 934 EKNKRLMKTIE---ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELE 989
E + +T + EL+ +++D+ N K ++ M K + +E E + R ELE + EL+
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNN-KKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 990 ELKQRYK-ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + K +LD+ E C KQ E + K ++E L+ +K +K E + L+
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAES--KQLNV 638
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ + + + SA + +ITD ++ + KK++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Score = 44.8 bits (101), Expect = 0.002
Identities = 98/533 (18%), Positives = 203/533 (38%), Gaps = 45/533 (8%)
Query: 270 LELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
L+ +++ L+E + EN + +K + + N L E + K K +R +
Sbjct: 151 LQFGNEKVSLKLEEGIQENKDL----IKENNATRHLCNLLKETCARSAEKTKKYEYER-E 205
Query: 330 DSLLAVLDAEFGTTSL-DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
++ +D + FE L N ++ E Y K+Q E E+
Sbjct: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
Query: 389 EKLASLNSQLIEKENACN----ILRIQKERIHEISSAVTI--DIVKKENELKEILTKECL 442
++++ L Q+ EKEN +L +++++++ + + +K+ E + LTKE
Sbjct: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE-- 323
Query: 443 KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXX 502
L +K+ + R + + + I + E T E + +
Sbjct: 324 -LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
Query: 503 XXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
LE+ +++K L EL K S+++E N ++ E++ LK
Sbjct: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKK-SSELEEMTKLTNNKEV---ELEELKK 438
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV 622
+ + E +L ++ + ++ + G ++E L + + E Q + + S Q
Sbjct: 439 VLGEKE----TLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 623 IKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
+ +L +++ + L + + + L LK Q E+ + +
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 682 LEINIKTHEKTAEIQNRMIMRLQ------KQIQEDDKLFIEK-ETKLNELT------NKY 728
E +K E E + ++ L+ KQ +++ K ++K E N L NKY
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 729 --------EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
+ALK+ A K L VN+L + + + + E+ + E
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
Score = 39.5 bits (88), Expect = 0.065
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 24/274 (8%)
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
V +++E+ Q + +L ++ ++ ++ +EL E + L+E ++ L KE +
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLM 940
+ LKE + E+ K+ T + + +L++ + ++ E+ +N RL
Sbjct: 181 HLCNLLKETCA--RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRL- 237
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
E+ +K LK K+Q ++Y K E K K++ ++ E + + K+L
Sbjct: 238 ----EMHFK---LKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 1001 ECETCAEYLKQREEQCKRLKE-AKIALE----IVDKLSNQKVALEKQIESLSNTPVSNST 1055
E + + Q EE+ K E K ++E + +L + KV+L++ S+S
Sbjct: 288 LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR---SVSTQKALEED 344
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ +AT + ++ M+E+ K + ++ ++T
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Score = 39.5 bits (88), Expect = 0.065
Identities = 65/272 (23%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTRDLL---MSQIKSLE 116
+ L + ++++ L+L+ ++ + K+Q+ + + +NL ETQ R+ L ++K
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 117 ME---NLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK---EVD 169
E L K +E NL ++ K+K I ELQ+EN L + ES LN +V+
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK---KGTAESKQLNVYEIKVN 644
Query: 170 DLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-L 226
L+ E QK ++ + + KI +N+ + + K +I + + K
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIADEAVKLQKEIDKRC 703
Query: 227 NRSISD-----SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD- 280
I++ +Y+KI + + + G KE ++ +S++ LE+ N+ +
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIE-ERDSELGLYKSKE--QEQSSLRASLEIELSNLKAEL 760
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
L K E E K K+ E K N +L E+
Sbjct: 761 LSVKKQLEIEREEKE-KLKREAKENTATLKEK 791
>BC060769-1|AAH60769.2| 1107|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1107
Score = 75.4 bits (177), Expect = 1e-12
Identities = 195/1014 (19%), Positives = 404/1014 (39%), Gaps = 85/1014 (8%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK----NLTDSLKTKSKK 139
I+ K A E + Q ++ ET+ + L Q KS E L ++I+ +L D +K K +
Sbjct: 36 IQALKDAHEEEIQQILAETREKIL---QYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 92
Query: 140 INELQEENDTLSNLIM----ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ E + + ++ + ++V +++EV+++++ E + L+ + E + +
Sbjct: 93 LTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQ-VQFEKDKR 151
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ +++ Q ++ + + L D++ S +N+ + R ++ +L L+ R +
Sbjct: 152 LALEDL--QAAHRQEIQELLKSQQDHSAS-VNKGQEKAEELHRM-EVESLNKMLEELRLE 207
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL---SEQ 312
K+L ED+ + L + +LD L + F ++++ E + +L E
Sbjct: 208 RKKLIEDY---EGKLNKAQSFYERELDT-LKRSQLFTAESLQASKEKEADLRKEFQGQEA 263
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK 372
++ K K + +D ++LD L + +N + Q LD+ E
Sbjct: 264 ILRKTIGKLKTELQMVQDEAGSLLDK---CQKLQTALAIAENNVQVLQKQLDDAKEGEMA 320
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
+ E SEL + E+L S L+ K + +L+ + + + +
Sbjct: 321 LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 380
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKL 490
L ++ + SK + Q L KK+ Y EL +E+E
Sbjct: 381 LSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 440
Query: 491 RLETGTAK-----------AVXXXXXXXXXXXXXXFDTLEEAHNEVK-SLHEELTKLYKS 538
+L +K A+ LEE HN+ K +L E+ +L +
Sbjct: 441 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE 500
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKM-------LSLSEKDNKL-TELVSTING 590
+ + + ++EI L+ + K+E+ + SL + +L EL T +
Sbjct: 501 LENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDS 560
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI------LMXXXXX 644
LKE ++L ++ + E+E Q E E + ++ ++DKM D+ +
Sbjct: 561 LKETKDALLNVEGEL--EQERQQHE-ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 617
Query: 645 XXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI-----NIKTHEKTAEIQ--- 696
++ KS + Q L LK++ + RD + ++ I ++ EIQ
Sbjct: 618 KLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQ 677
Query: 697 -NRMIMRLQKQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
+ +LQ Q QE +L E E + ++++LK + A + +E +E Q
Sbjct: 678 SQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEK-EQRAL 736
Query: 755 QKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL--GENP 812
+ L + AEL+S DE + +
Sbjct: 737 ENHLQQKHSAELQS------LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 790
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L+ +I ++ + +L + ++ +D + + KE E L+ R+
Sbjct: 791 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 850
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYD 930
+ L KE L + +S L +++ + + + R ++ + E N +D M+ D
Sbjct: 851 SELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTAD 910
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE---DCKAE 987
EKN +M+ + + LK +Q ++E+ +K E+K ++++ + KA
Sbjct: 911 HLREKN--IMRA--DFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAM 966
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
L E Q K+L E+ + L RE ++ + + +++ L+ QK +K
Sbjct: 967 LTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDK 1020
Score = 48.8 bits (111), Expect = 1e-04
Identities = 105/543 (19%), Positives = 232/543 (42%), Gaps = 40/543 (7%)
Query: 521 AHNEVKSLH-EELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
A ++++ H +E+ +L KS+ D ++A++N + +EE+ +++ ++ KML +
Sbjct: 153 ALEDLQAAHRQEIQELLKSQQD-HSASVNKGQEKAEELHRMEV---ESLNKMLEELRLER 208
Query: 580 KLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK-MKADI 637
K +L+ G L + + + D + R + A L+ S K+ +L K +
Sbjct: 209 K--KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQAS----KEKEADLRKEFQGQE 262
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQ------NLALKE---QCEEKTRDCSRLEINIKT 688
+ DEA SLL++ LA+ E Q +K D ++ E +
Sbjct: 263 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAK-EGEMAL 321
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
K E+++ + ++ Q+ L + K + + L +A + + +KDLES +
Sbjct: 322 LSKHKEVESELAAARERLQQQASDLVL-KASHIGML----QATQMTQEVTIKDLESEKSR 376
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
VN+ +Q + + + EQ + ++R
Sbjct: 377 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLE 436
Query: 809 GENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELD-DLKERYKELDDECETCAEY 864
E +L+++ +++ ++ + + + +++L DL+E++ + E
Sbjct: 437 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 496
Query: 865 LQERDEQCARLKKEKLSL-EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
LQ+ E + ++KL+ Q++ +L++ +R E+ A+ + + +D
Sbjct: 497 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKS---EQGLGSAEGLIASLQDSQERLQNE 553
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME-KYTKKDKEFEAKRKE-- 980
+D ++ D+ E L+ EL ++Q + T+ M++ + K K + E K E
Sbjct: 554 LD-LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENL 612
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALE 1040
++C EEL+ +++E + + LK RE+ R K ++++++S K LE
Sbjct: 613 RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLE 672
Query: 1041 KQI 1043
Q+
Sbjct: 673 IQL 675
Score = 44.0 bits (99), Expect = 0.003
Identities = 51/226 (22%), Positives = 106/226 (46%), Gaps = 13/226 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+SE S++ ERL ++E L+ + + LD+E + L+++ + R ++E E+++
Sbjct: 371 ESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE--YYEREL 428
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
NL+ ++ E + + T E+ A H + ++ + +A +K K M E+
Sbjct: 429 KNLQSRLE-----EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQH 483
Query: 947 RYKKQDLKNTVTKMQKAME--KYTKKDKEFEAKRK--ELEDCKAELEELKQRYKELDEEC 1002
K +L+ ++Q+ +E K +DK A ++ L+D + E+ + L
Sbjct: 484 NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL 543
Query: 1003 ETCAEYLKQREEQCK-RLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
+ E L+ + K LKE K A L + +L ++ E+ I ++
Sbjct: 544 QDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 589
Score = 40.7 bits (91), Expect = 0.028
Identities = 147/677 (21%), Positives = 270/677 (39%), Gaps = 83/677 (12%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
QSL E + L+LEK E +++ E K LE + L + K+LE
Sbjct: 396 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAW 455
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE---- 176
I+ + + KK+ EE L +E + + L +E+++LK+ E
Sbjct: 456 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEE--DKNQLQQELENLKEVLEDKLN 513
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q+ L+ +V +SE +G E LI SL + ++L+ + DS
Sbjct: 514 TANQEIGHLQDMVRKSEQGLGS---------AEGLIASLQDSQERLQNELDLT-KDSLKE 563
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
T+ + + ++ EL+ R+ + E ++K +L M DL+ K EN E
Sbjct: 564 TK-DALLNVEGELEQERQQHE---ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQE---- 615
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
S+++ L +L + E KKS LL + D E + D ++ +++++
Sbjct: 616 --CSKLREEL-----RLQHEEDKKSA------MSQLLQLKDRE-KNAARDSWQKKVEDLL 661
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
N QI L L++ ++Q L++ + L+ + + +L ++ Q+ +
Sbjct: 662 N--QISL---LKQNLEIQ--LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 714
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ + + +++E E KE E + L+ +L AH++ F + Q
Sbjct: 715 KEAHVLAFQTMEEEKE-KEQRALE----NHLQQKHSAELQSLKDAHRESMEGFRIEMEQ- 768
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN-EVKSLHEELTKL 535
EL +E+E E G A + D L H+ E+ + EL +
Sbjct: 769 ELQTLRFELEDE------GKA-MLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERS 821
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
++ ++ I L EE+ ++ E +SE D ++ L I+ L +E
Sbjct: 822 IDISRRQSKEHICRITDLQEEL--------RHREH--HISELDKEVQHLHENISALTKE- 870
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
K + R + Q L + K+ ELD M AD L
Sbjct: 871 LEFKGKEILRIRSESNQQIRLHEQ-DLNKRLEKELDVMTADHLREKNIMRADFNKTNELL 929
Query: 656 DEAKSLLEQNLALKEQCEEK--TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E + L+ +L E+ EEK R+ +I + T K + I+ K++ ED+K
Sbjct: 930 KEINAALQVSL---EEMEEKYLMRESKPEDIQMITELKAMLTERDQII---KKLIEDNKF 983
Query: 714 F----IEKETKLNELTN 726
+ + +ET N++ N
Sbjct: 984 YQLELVNRETNFNKVFN 1000
Score = 37.9 bits (84), Expect = 0.20
Identities = 35/191 (18%), Positives = 84/191 (43%), Gaps = 5/191 (2%)
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR 874
+D + +I + D+ ++++ L ++++ K + E + + + L+ E +
Sbjct: 29 NDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTE-ELDLRRKIQVLESSLEDHIK 87
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
+K++ L+ + + E ++ + + ++ +E + + E
Sbjct: 88 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 147
Query: 935 KNKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELEELK 992
K+KRL +E+L+ +Q+++ + Q K ++K E R E+E LEEL+
Sbjct: 148 KDKRL--ALEDLQAAHRQEIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 205
Query: 993 QRYKELDEECE 1003
K+L E+ E
Sbjct: 206 LERKKLIEDYE 216
Score = 33.1 bits (72), Expect = 5.7
Identities = 77/376 (20%), Positives = 156/376 (41%), Gaps = 29/376 (7%)
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD-LESSREAVNQ- 751
+ M ++L K+I + K+ TK +E + +ALK ++ ++ L +RE + Q
Sbjct: 2 DYSQEMHLKLSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQY 61
Query: 752 ---LTTQKDL---VEGRIAELESDIRTEQTA-TVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+T + DL ++ + LE I+ +Q A T
Sbjct: 62 KSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTM 121
Query: 805 NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAE 863
+R++ E + + RS + + L Q +++E K D + +
Sbjct: 122 SREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRQEIQELLKSQQDHSASVNK 181
Query: 864 YLQERDEQCARLKKEKLS--LEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLH 920
QE+ E+ R++ E L+ LE+ K+ I + + + F + ++T + + L
Sbjct: 182 G-QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKR-SQLF 239
Query: 921 SVVVDRMSYDAEVEKNKR-------LMKTIEELRYKKQDLKNT----VTKMQKAMEKYTK 969
+ + S + E + K L KTI +L+ + Q +++ + K QK
Sbjct: 240 TAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAI 299
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIV 1029
+ + +K+L+D K L ++KE++ E E L+Q+ LK + I +
Sbjct: 300 AENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLV-LKASHIGMLQA 358
Query: 1030 DKLSNQKVALEKQIES 1045
+++ Q+V + K +ES
Sbjct: 359 TQMT-QEVTI-KDLES 372
>AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 75.4 bits (177), Expect = 1e-12
Identities = 132/616 (21%), Positives = 266/616 (43%), Gaps = 52/616 (8%)
Query: 69 EINLKLEKLSGEL-FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK 127
E+ ++ E E+ F +KE ++ Q E ++ Q+ L ++ K+ ++K
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE---KQVSLLLIQITEKENKMK 283
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
+LT L+ K+N+L+E+ S + +++ + +L KE++D+K + Q+ + +K
Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS----LQRSVSTQK 339
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
+ E + +I K IC + KE ++ ++ ++ S + T +C+L+
Sbjct: 340 AL-EEDLQIATKTICQLTEEKETQME------ESNKARAAHSFVVTEFET---TVCSLE- 388
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
EL + E ED I +EL + + ++ KL N E E + +K + K L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILT-MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL- 446
Query: 308 SLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL 367
L E N + +K + + + L+ +L A + EI + I Q E+
Sbjct: 447 -LYE---NKQFEKIAEELKGTEQELIGLLQAR--EKEVHDLEIQLTAITTSEQYYSKEVK 500
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSAVTIDI 426
+ T+++ + + T EL S KL+ N +L ++ + + L+ Q+E I+ + +
Sbjct: 501 DLKTELENEKLKNT-ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERM 558
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ L+E T+ +L ++ ++ + D+ K + L Q E ++ Y
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVE-NKNKY--- 614
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
E+L+ E K + LE K E+T Y+ ++++ +
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 547 LNLIKILSEEIDALKIAIAKNEEKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDV 604
+ L EE++ K+ IA K+ +K +K+ E+V+ + K + + + D
Sbjct: 675 ---EENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
Query: 605 ---ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ + KE + S L S ++ EL +KA++L EAK
Sbjct: 731 ELGLYKSKEQEQSSLRASLEI------ELSNLKAELLSVKKQLEIEREEKEKLKREAK-- 782
Query: 662 LEQNLALKEQCEEKTR 677
E LKE+ ++KT+
Sbjct: 783 -ENTATLKEKKDKKTQ 797
Score = 56.8 bits (131), Expect = 4e-07
Identities = 109/536 (20%), Positives = 221/536 (41%), Gaps = 56/536 (10%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLS 575
L+E + +++ L +E K K E +L LI+I +E + L + ++ +K+ L
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDK--EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDV---ITREKETQASELERSCQVIKQNGFELDK 632
EK +E + ++++++ K L D+ + R TQ + LE Q+ + +L +
Sbjct: 301 EKTKLQSENLK--QSIEKQHHLTKELEDIKVSLQRSVSTQKA-LEEDLQIATKTICQLTE 357
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
K + + LE+ L ++Q EK D +L+I T
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED--QLKI------LT 409
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E+Q + +++E KL KE +L EL K K K E E +
Sbjct: 410 MELQKK-----SSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKG- 462
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T+++L+ G + E ++ + + E +DL
Sbjct: 463 -TEQELI-GLLQAREKEVHDLEIQLTAITTSEQY--------------YSKEVKDL--KT 504
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L++ ++ + S L+ + L+ QE D+ K ++ + + +Q
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELT--QETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
L++ + L ++ ++E+++ Q+ E + K ++E+ NL V ++ Y E
Sbjct: 563 ENLQETETQLRNELEYVREELK-QKRDEVKCKLD----KSEENCNNLRKQVENKNKYIEE 617
Query: 933 VEK-NKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAEL 988
+++ NK L K T E + ++K V K++ +E +K E + +KE+ED K
Sbjct: 618 LQQENKALKKKGTAESKQLNVYEIK--VNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
E L + ++ + + K+ +++C+ +AL K K+ E+ E
Sbjct: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSE 731
Score = 50.8 bits (116), Expect = 3e-05
Identities = 61/268 (22%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
++++ + ++ L++ +++ +L+++ + +E L++ E+ L KE LE +
Sbjct: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE---LEDIKVS 330
Query: 889 LKEQIRTQQPVERQAKFADVAVN--TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + TQ+ +E + A + T+E + R ++ V + + + ++EEL
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 947 -RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
R ++Q L+ +++ + KK E E K + + ELEELK K L E+ ET
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK---KVLGEK-ETL 446
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
KQ E+ + LK + E++ L A EK++ L + T S
Sbjct: 447 LYENKQFEKIAEELKGTE--QELIGLLQ----AREKEVHDL------EIQLTAITTSEQY 494
Query: 1066 QNQQITDVMKENQKLKKMNAKLITICKK 1093
++++ D+ E + K N +L + C K
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNK 522
Score = 47.2 bits (107), Expect = 3e-04
Identities = 124/576 (21%), Positives = 250/576 (43%), Gaps = 60/576 (10%)
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+SK+ EN KI+ + A++ NE+ L L E + +L+ +ENN
Sbjct: 131 ESKLQENR------KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI-------KENN 177
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + L +++ KET A RS + K+ +E ++ + +
Sbjct: 178 ATRHLCNLL---KETCA----RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
Query: 657 EAK-SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+A+ S LE + LKE EK + + E + ++K ++ +I +K+ + D F+
Sbjct: 231 QAENSRLEMHFKLKED-YEKIQHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 716 --EKETKLNELTNK----YEALKRDYDA---AVKDLESSREAVNQ-LTTQKDLVEG-RIA 764
E K+N+L K E LK+ + K+LE + ++ + ++TQK L E +IA
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD--DSPKRSI 822
TE+ T E E +L+ + + +
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 823 SVISDSEVSQLKE--RLLSCQQ-ELDDLKERYKELD------DECETCAEYLQERDEQCA 873
++ + S+L+E +L + ++ EL++LK+ E + + E AE L+ +++
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L + + E++V +L+ Q+ E+ + T+ + L + + +
Sbjct: 469 GLLQAR---EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 934 EKNKRLMKTIE---ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELE 989
E + +T + EL+ +++D+ N K ++ M K + +E E + R ELE + EL+
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNN-KKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 990 ELKQRYK-ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + K +LD+ E C KQ E + K ++E L+ +K +K E + L+
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAES--KQLNV 638
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ + + + SA + +ITD ++ + KK++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Score = 44.8 bits (101), Expect = 0.002
Identities = 98/533 (18%), Positives = 203/533 (38%), Gaps = 45/533 (8%)
Query: 270 LELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
L+ +++ L+E + EN + +K + + N L E + K K +R +
Sbjct: 151 LQFGNEKVSLKLEEGIQENKDL----IKENNATRHLCNLLKETCARSAEKTKKYEYER-E 205
Query: 330 DSLLAVLDAEFGTTSL-DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
++ +D + FE L N ++ E Y K+Q E E+
Sbjct: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
Query: 389 EKLASLNSQLIEKENACN----ILRIQKERIHEISSAVTI--DIVKKENELKEILTKECL 442
++++ L Q+ EKEN +L +++++++ + + +K+ E + LTKE
Sbjct: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE-- 323
Query: 443 KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXX 502
L +K+ + R + + + I + E T E + +
Sbjct: 324 -LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
Query: 503 XXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
LE+ +++K L EL K S+++E N ++ E++ LK
Sbjct: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKK-SSELEEMTKLTNNKEV---ELEELKK 438
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV 622
+ + E +L ++ + ++ + G ++E L + + E Q + + S Q
Sbjct: 439 VLGEKE----TLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 623 IKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
+ +L +++ + L + + + L LK Q E+ + +
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 682 LEINIKTHEKTAEIQNRMIMRLQ------KQIQEDDKLFIEK-ETKLNELT------NKY 728
E +K E E + ++ L+ KQ +++ K ++K E N L NKY
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 729 --------EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
+ALK+ A K L VN+L + + + + E+ + E
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
Score = 39.5 bits (88), Expect = 0.065
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 24/274 (8%)
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
V +++E+ Q + +L ++ ++ ++ +EL E + L+E ++ L KE +
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLM 940
+ LKE + E+ K+ T + + +L++ + ++ E+ +N RL
Sbjct: 181 HLCNLLKETCA--RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRL- 237
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
E+ +K LK K+Q ++Y K E K K++ ++ E + + K+L
Sbjct: 238 ----EMHFK---LKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 1001 ECETCAEYLKQREEQCKRLKE-AKIALE----IVDKLSNQKVALEKQIESLSNTPVSNST 1055
E + + Q EE+ K E K ++E + +L + KV+L++ S+S
Sbjct: 288 LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR---SVSTQKALEED 344
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ +AT + ++ M+E+ K + ++ ++T
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Score = 39.5 bits (88), Expect = 0.065
Identities = 65/272 (23%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTRDLL---MSQIKSLE 116
+ L + ++++ L+L+ ++ + K+Q+ + + +NL ETQ R+ L ++K
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 117 ME---NLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK---EVD 169
E L K +E NL ++ K+K I ELQ+EN L + ES LN +V+
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK---KGTAESKQLNVYEIKVN 644
Query: 170 DLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-L 226
L+ E QK ++ + + KI +N+ + + K +I + + K
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIADEAVKLQKEIDKRC 703
Query: 227 NRSISD-----SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD- 280
I++ +Y+KI + + + G KE ++ +S++ LE+ N+ +
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIE-ERDSELGLYKSKE--QEQSSLRASLEIELSNLKAEL 760
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
L K E E K K+ E K N +L E+
Sbjct: 761 LSVKKQLEIEREEKE-KLKREAKENTATLKEK 791
>AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 75.4 bits (177), Expect = 1e-12
Identities = 132/616 (21%), Positives = 266/616 (43%), Gaps = 52/616 (8%)
Query: 69 EINLKLEKLSGEL-FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK 127
E+ ++ E E+ F +KE ++ Q E ++ Q+ L ++ K+ ++K
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE---KQVSLLLIQITEKENKMK 283
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
+LT L+ K+N+L+E+ S + +++ + +L KE++D+K + Q+ + +K
Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS----LQRSVSTQK 339
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
+ E + +I K IC + KE ++ ++ ++ S + T +C+L+
Sbjct: 340 AL-EEDLQIATKTICQLTEEKETQME------ESNKARAAHSFVVTEFET---TVCSLE- 388
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
EL + E ED I +EL + + ++ KL N E E + +K + K L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILT-MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL- 446
Query: 308 SLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL 367
L E N + +K + + + L+ +L A + EI + I Q E+
Sbjct: 447 -LYE---NKQFEKIAEELKGTEQELIGLLQAR--EKEVHDLEIQLTAITTSEQYYSKEVK 500
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSAVTIDI 426
+ T+++ + + T EL S KL+ N +L ++ + + L+ Q+E I+ + +
Sbjct: 501 DLKTELENEKLKNT-ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERM 558
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ L+E T+ +L ++ ++ + D+ K + L Q E ++ Y
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVE-NKNKY--- 614
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
E+L+ E K + LE K E+T Y+ ++++ +
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 547 LNLIKILSEEIDALKIAIAKNEEKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDV 604
+ L EE++ K+ IA K+ +K +K+ E+V+ + K + + + D
Sbjct: 675 ---EENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
Query: 605 ---ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ + KE + S L S ++ EL +KA++L EAK
Sbjct: 731 ELGLYKSKEQEQSSLRASLEI------ELSNLKAELLSVKKQLEIEREEKEKLKREAK-- 782
Query: 662 LEQNLALKEQCEEKTR 677
E LKE+ ++KT+
Sbjct: 783 -ENTATLKEKKDKKTQ 797
Score = 56.8 bits (131), Expect = 4e-07
Identities = 109/536 (20%), Positives = 221/536 (41%), Gaps = 56/536 (10%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLS 575
L+E + +++ L +E K K E +L LI+I +E + L + ++ +K+ L
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDK--EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDV---ITREKETQASELERSCQVIKQNGFELDK 632
EK +E + ++++++ K L D+ + R TQ + LE Q+ + +L +
Sbjct: 301 EKTKLQSENLK--QSIEKQHHLTKELEDIKVSLQRSVSTQKA-LEEDLQIATKTICQLTE 357
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
K + + LE+ L ++Q EK D +L+I T
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED--QLKI------LT 409
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E+Q + +++E KL KE +L EL K K K E E +
Sbjct: 410 MELQKK-----SSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKG- 462
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T+++L+ G + E ++ + + E +DL
Sbjct: 463 -TEQELI-GLLQAREKEVHDLEIQLTAITTSEQY--------------YSKEVKDL--KT 504
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L++ ++ + S L+ + L+ QE D+ K ++ + + +Q
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELT--QETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
L++ + L ++ ++E+++ Q+ E + K ++E+ NL V ++ Y E
Sbjct: 563 ENLQETETQLRNELEYVREELK-QKRDEVKCKLD----KSEENCNNLRKQVENKNKYIEE 617
Query: 933 VEK-NKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAEL 988
+++ NK L K T E + ++K V K++ +E +K E + +KE+ED K
Sbjct: 618 LQQENKALKKKGTAESKQLNVYEIK--VNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
E L + ++ + + K+ +++C+ +AL K K+ E+ E
Sbjct: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSE 731
Score = 50.8 bits (116), Expect = 3e-05
Identities = 61/268 (22%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
++++ + ++ L++ +++ +L+++ + +E L++ E+ L KE LE +
Sbjct: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE---LEDIKVS 330
Query: 889 LKEQIRTQQPVERQAKFADVAVN--TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + TQ+ +E + A + T+E + R ++ V + + + ++EEL
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 947 -RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
R ++Q L+ +++ + KK E E K + + ELEELK K L E+ ET
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK---KVLGEK-ETL 446
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
KQ E+ + LK + E++ L A EK++ L + T S
Sbjct: 447 LYENKQFEKIAEELKGTE--QELIGLLQ----AREKEVHDL------EIQLTAITTSEQY 494
Query: 1066 QNQQITDVMKENQKLKKMNAKLITICKK 1093
++++ D+ E + K N +L + C K
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNK 522
Score = 47.2 bits (107), Expect = 3e-04
Identities = 124/576 (21%), Positives = 250/576 (43%), Gaps = 60/576 (10%)
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+SK+ EN KI+ + A++ NE+ L L E + +L+ +ENN
Sbjct: 131 ESKLQENR------KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI-------KENN 177
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + L +++ KET A RS + K+ +E ++ + +
Sbjct: 178 ATRHLCNLL---KETCA----RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
Query: 657 EAK-SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+A+ S LE + LKE EK + + E + ++K ++ +I +K+ + D F+
Sbjct: 231 QAENSRLEMHFKLKED-YEKIQHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 716 --EKETKLNELTNK----YEALKRDYDA---AVKDLESSREAVNQ-LTTQKDLVEG-RIA 764
E K+N+L K E LK+ + K+LE + ++ + ++TQK L E +IA
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD--DSPKRSI 822
TE+ T E E +L+ + + +
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 823 SVISDSEVSQLKE--RLLSCQQ-ELDDLKERYKELD------DECETCAEYLQERDEQCA 873
++ + S+L+E +L + ++ EL++LK+ E + + E AE L+ +++
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L + + E++V +L+ Q+ E+ + T+ + L + + +
Sbjct: 469 GLLQAR---EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 934 EKNKRLMKTIE---ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELE 989
E + +T + EL+ +++D+ N K ++ M K + +E E + R ELE + EL+
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNN-KKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 990 ELKQRYK-ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + K +LD+ E C KQ E + K ++E L+ +K +K E + L+
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAES--KQLNV 638
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ + + + SA + +ITD ++ + KK++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Score = 44.8 bits (101), Expect = 0.002
Identities = 98/533 (18%), Positives = 203/533 (38%), Gaps = 45/533 (8%)
Query: 270 LELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
L+ +++ L+E + EN + +K + + N L E + K K +R +
Sbjct: 151 LQFGNEKVSLKLEEGIQENKDL----IKENNATRHLCNLLKETCARSAEKTKKYEYER-E 205
Query: 330 DSLLAVLDAEFGTTSL-DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
++ +D + FE L N ++ E Y K+Q E E+
Sbjct: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
Query: 389 EKLASLNSQLIEKENACN----ILRIQKERIHEISSAVTI--DIVKKENELKEILTKECL 442
++++ L Q+ EKEN +L +++++++ + + +K+ E + LTKE
Sbjct: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE-- 323
Query: 443 KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXX 502
L +K+ + R + + + I + E T E + +
Sbjct: 324 -LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
Query: 503 XXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
LE+ +++K L EL K S+++E N ++ E++ LK
Sbjct: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKK-SSELEEMTKLTNNKEV---ELEELKK 438
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV 622
+ + E +L ++ + ++ + G ++E L + + E Q + + S Q
Sbjct: 439 VLGEKE----TLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 623 IKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
+ +L +++ + L + + + L LK Q E+ + +
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 682 LEINIKTHEKTAEIQNRMIMRLQ------KQIQEDDKLFIEK-ETKLNELT------NKY 728
E +K E E + ++ L+ KQ +++ K ++K E N L NKY
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 729 --------EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
+ALK+ A K L VN+L + + + + E+ + E
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
Score = 39.5 bits (88), Expect = 0.065
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 24/274 (8%)
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
V +++E+ Q + +L ++ ++ ++ +EL E + L+E ++ L KE +
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLM 940
+ LKE + E+ K+ T + + +L++ + ++ E+ +N RL
Sbjct: 181 HLCNLLKETCA--RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRL- 237
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
E+ +K LK K+Q ++Y K E K K++ ++ E + + K+L
Sbjct: 238 ----EMHFK---LKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 1001 ECETCAEYLKQREEQCKRLKE-AKIALE----IVDKLSNQKVALEKQIESLSNTPVSNST 1055
E + + Q EE+ K E K ++E + +L + KV+L++ S+S
Sbjct: 288 LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR---SVSTQKALEED 344
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ +AT + ++ M+E+ K + ++ ++T
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Score = 39.5 bits (88), Expect = 0.065
Identities = 65/272 (23%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTRDLL---MSQIKSLE 116
+ L + ++++ L+L+ ++ + K+Q+ + + +NL ETQ R+ L ++K
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 117 ME---NLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK---EVD 169
E L K +E NL ++ K+K I ELQ+EN L + ES LN +V+
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK---KGTAESKQLNVYEIKVN 644
Query: 170 DLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-L 226
L+ E QK ++ + + KI +N+ + + K +I + + K
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIADEAVKLQKEIDKRC 703
Query: 227 NRSISD-----SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD- 280
I++ +Y+KI + + + G KE ++ +S++ LE+ N+ +
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIE-ERDSELGLYKSKE--QEQSSLRASLEIELSNLKAEL 760
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
L K E E K K+ E K N +L E+
Sbjct: 761 LSVKKQLEIEREEKE-KLKREAKENTATLKEK 791
>AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a variant
protein.
Length = 1065
Score = 75.4 bits (177), Expect = 1e-12
Identities = 146/719 (20%), Positives = 300/719 (41%), Gaps = 63/719 (8%)
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
Q+L+ E D L +++ + +++ I L L + +++ EL+ + SN
Sbjct: 222 QSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLE--SNKPA 279
Query: 156 ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSL 215
+V S +L +E+ L++ E +T+ D ++ + + G + Q ++K +
Sbjct: 280 GDVDMSLSLLQEISSLQEKLE-VTRT--DHQREITSLKEHFGAREETHQKEIKALYTATE 336
Query: 216 HIGYDNTL--SKLNRSISDSNTSTRYNKICTLQSELDAGREDCKEL-----------CED 262
+ +N SKL + +++ K L++ + + ++ +EL +
Sbjct: 337 KLSKENESLKSKLEHANKENSDVIALWK-SKLETAIASHQQAMEELKVSFSKGLGTETAE 395
Query: 263 FTSIKNHLEL------HE-PNMTMDLD-EKLGENNEFETKAVKVMSEIKRNLNSLSEQLI 314
F +K +E HE N+ D E+ E E K+M IK NSL + I
Sbjct: 396 FAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL--EAI 453
Query: 315 NNESKKSKD-HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV 373
++ K++D H+ +D+L + +AE + F + ++ Q + E + K +
Sbjct: 454 RSKLDKAEDQHLVEMEDTLNKLQEAEI---KKEKFAEASEEAVS-VQRSMQETVNKLHQK 509
Query: 374 QGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI-HEISSAVTI--DIVKKE 430
+ N +S+L+ + E LA + ++ EK+ L KE++ ++I+ + + D +
Sbjct: 510 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 569
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT-ILFDALITQYELSRTDYEIEKEK 489
++ + L + + +L++ + + + K I + A +Q E ++ E +KE
Sbjct: 570 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 629
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE-LTKLYKSKVDENNA--- 545
R + K + E A +E K+ HEE L L K+ +D +
Sbjct: 630 ERKLSDLEKKMETSHNQCQELKARY----ERATSETKTKHEEILQNLQKTLLDTEDKLKG 685
Query: 546 ----NLNLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNK-LTELVSTINGLKEENNSLK 599
N L++ L E A K A+ E + + E+ K TE ++++ K+ N L+
Sbjct: 686 AREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 745
Query: 600 SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAK 659
+ D + EL +S +++ ++++ + +I +E
Sbjct: 746 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 805
Query: 660 SLLEQ------NLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRMIMRLQKQIQEDDK 712
L E+ + ++ EE+ + + +K E K + + LQK I
Sbjct: 806 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSA 865
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
L EK+ +L +L N+ L R +A+ K L S V L + K +E ++ LE ++
Sbjct: 866 LLTEKDAELEKLRNEVTVL-RGENASAKSLHS---VVQTLESDKVKLELKVKNLELQLK 920
Score = 68.1 bits (159), Expect = 2e-10
Identities = 140/730 (19%), Positives = 284/730 (38%), Gaps = 40/730 (5%)
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEI 436
LN+ E + V + + + I K + +++ RI E+ ++ + K + +E+
Sbjct: 179 LNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQREL 238
Query: 437 LTKECLKLSKLKIDIPRDLDQDLPAH-KKITILFDALITQYELSRTDYEIEK-EKLRLET 494
+S+ K I +L++DL +++ L L + D + +++
Sbjct: 239 EDTRVATVSE-KSRI-MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQ 296
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEAHN-EVKSLHEELTKLYKSKVDENNANLNLIKIL 553
+ F EE H E+K+L+ KL K + + L
Sbjct: 297 EKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK---ENESLKSKLEHAN 353
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
E D + + +K E + S + +L VS GL E L I + +
Sbjct: 354 KENSDVIALWKSKLETAIASHQQAMEELK--VSFSKGLGTETAEFAELKTQIEKMRLDYQ 411
Query: 614 SELE--RSCQVIKQ--NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK 669
E+E ++ Q ++ + E++ ++A ++ D+A+ +Q+L
Sbjct: 412 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE---DQHLVEM 468
Query: 670 EQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
E K + E IK EK AE + +Q+ +QE +KE + N L++ E
Sbjct: 469 EDTLNKLQ-----EAEIKK-EKFAEASEEAVS-VQRSMQETVNKLHQKEEQFNMLSSDLE 521
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
L+ + E QL K+ +E IAE+ + + ++ +
Sbjct: 522 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI-MKMSGDNSSQLTKMNDELRLKE 580
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLD-----DSPKRSISVISDSEVSQLKERLLSCQQEL 844
T +EN + D + ++ + + E +L+ +L ++++
Sbjct: 581 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 640
Query: 845 DDLKERYKELDDECE-TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ----IRTQQPV 899
+ + +EL E +E + +E L+K L E ++ +E+ ++ + +
Sbjct: 641 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 700
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEEL-RYKKQDLKNTV 957
+QA+ A A ++ + + ++ A +E K+ K EL K+ +LKN V
Sbjct: 701 RKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKN-V 759
Query: 958 TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL-KQREEQC 1016
++ K+ E T ++++ E RKE+E K + Q+ L EE AE L + R+E
Sbjct: 760 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 819
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQ-NQQITDVMK 1075
K + + ++L K K I+ S T + + + + ++ +
Sbjct: 820 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 879
Query: 1076 ENQKLKKMNA 1085
E L+ NA
Sbjct: 880 EVTVLRGENA 889
Score = 63.7 bits (148), Expect = 4e-09
Identities = 112/547 (20%), Positives = 220/547 (40%), Gaps = 50/547 (9%)
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
T F L TQ E R DY+ E E L+ + + +A ++E N +
Sbjct: 393 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL--MKVIKEKENSL 450
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML--SLSEKDNKLTE 583
+++ +L K + E LN K+ EI K A A E + S+ E NKL +
Sbjct: 451 EAIRSKLDKAEDQHLVEMEDTLN--KLQEAEIKKEKFAEASEEAVSVQRSMQETVNKLHQ 508
Query: 584 LVSTINGLKEENNSLK-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
N L + L+ +L D+ + +E ER Q+IK +K++ DI
Sbjct: 509 KEEQFNMLSSDLEKLRENLADMEAKFREKD----EREEQLIKAK----EKLENDIAEIMK 560
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLA-LKEQCEEKTRDCSRLEINIKTHEKTAE-IQNRMI 700
DE + L E+++ L+ + + + S L+ +I+ AE Q
Sbjct: 561 MSGDNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 619
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV- 759
+ +++ +E ++ + E K+ N+ + LK Y+ A + ++ E + Q QK L+
Sbjct: 620 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ-NLQKTLLD 678
Query: 760 -EGRI--AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
E ++ A E+ ++ + E + + L+D
Sbjct: 679 TEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLAS--LED 736
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKE-------RYKELDDECETCAEYLQERD 869
+ + + + +E+ LKE L +EL+ KE + +E E ET + ++
Sbjct: 737 TKQTNAKL--QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 794
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV------------NTDEDWA 917
+Q + L++E + L +++ ++++ + Q +E + + + + DE+ A
Sbjct: 795 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 854
Query: 918 NLHSVVVDRMSY----DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
+L + + DAE+EK + + + + L + V ++ K K K
Sbjct: 855 SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN 914
Query: 974 FEAKRKE 980
E + KE
Sbjct: 915 LELQLKE 921
Score = 51.6 bits (118), Expect = 2e-05
Identities = 82/477 (17%), Positives = 195/477 (40%), Gaps = 48/477 (10%)
Query: 55 ISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS 114
+ K+ + +KE N + KL D E + +E ++ + + Q ++ +
Sbjct: 435 LRAKLMKVIKEKENSLEAIRSKL-----DKAEDQHLVE--MEDTLNKLQEAEIKKEKFAE 487
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
E ++ + ++ + L K ++ N L + + L + + + ++ + L K
Sbjct: 488 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 547
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGY---DNTLSKLNRSIS 231
E L ++ K+ ++ +++ N + +LKE ++ L + + S L +SI
Sbjct: 548 KEKLENDIAEIMKMSGDNSSQLTKMN--DELRLKERDVEELQLKLTKANENASFLQKSIE 605
Query: 232 DSNTSTRYN-----------------KICTLQSELDAGREDCKELCEDF------TSIKN 268
D + K+ L+ +++ C+EL + T K+
Sbjct: 606 DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 665
Query: 269 HLELHEPNMTM-DLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDR 327
L T+ D ++KL E + ++ + E+++ ++ + + + +
Sbjct: 666 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTK 725
Query: 328 YKDSLLAVLDAEFGTTSL--DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELK 385
K LA L+ T + + + L +N + + +L++ E T + E E++
Sbjct: 726 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVENQKMEEFRKEIE 784
Query: 386 SVNEKLASLNSQL--IEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLK 443
++ + A + QL +++EN + + R E++S +K E + +L + L+
Sbjct: 785 TLKQAAAQKSQQLSALQEENVKLAEELGRSR-DEVTSH------QKLEEERSVLNNQLLE 837
Query: 444 LSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAV 500
+ K + +D D++ + +K + AL+T+ + E LR E +AK++
Sbjct: 838 MKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL 894
Score = 49.6 bits (113), Expect = 6e-05
Identities = 121/605 (20%), Positives = 250/605 (41%), Gaps = 51/605 (8%)
Query: 28 DGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQ 87
+ KSK ++ + S+ I L S T Q+++E + L + E ++K Q
Sbjct: 343 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 402
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD--KEIKNLTDSLKTKSKKINELQE 145
+ YQ+ I Q + + EME L K IK +SL+ K+++ ++
Sbjct: 403 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 462
Query: 146 ENDTLSNLIMENVTESDNLNK--EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
++ V D LNK E + K+ +++ + +++ + E+ NK+ K
Sbjct: 463 QH---------LVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQRSMQETVNKLHQK---- 509
Query: 204 QCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDF 263
+ + N++ S L KL +++D R + +L +E + +
Sbjct: 510 --EEQFNMLSS-------DLEKLRENLADMEAKFREKD--EREEQLIKAKEKLENDIAEI 558
Query: 264 TSIK--NHLELHEPNMTMDLDEKLGENNEFE-TKAVKVMSEIKRNLNSLSEQLINNESKK 320
+ N +L + N + L E+ E + + TKA + S +++++ ++ + ++ +
Sbjct: 559 MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA 618
Query: 321 SKDHIDRYKD--SLLAVLDAEFGTTSLDVFEILM--DNIINKYQIDLDEILEKYTKVQGD 376
+K H + K+ L+ L+ + T+ E+ + ++ + +EIL+ K D
Sbjct: 619 AKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD 678
Query: 377 LNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEI 436
+ +LK E+ + L +L E + + + E + + + K++ E
Sbjct: 679 TED---KLKGAREENSGLLQELEELRKQAE--KAKAAQTAEDAMQIMEQMTKEKTETLAS 733
Query: 437 LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
L +KL+ ++ + +L +++ + L + + E KE L+
Sbjct: 734 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME---EFRKEIETLKQAA 790
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS---LHEELTKLYKSKVDENNANLNLIKIL 553
A+ + L + +EV S L EE + L ++ IK
Sbjct: 791 AQKSQQLSALQEENVKLA-EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDA 849
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI-TREKETQ 612
EE +L+ +I+ L+EKD +L +L + + L+ EN S KSL+ V+ T E +
Sbjct: 850 DEEKASLQKSISITSAL---LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKV 906
Query: 613 ASELE 617
EL+
Sbjct: 907 KLELK 911
Score = 43.6 bits (98), Expect = 0.004
Identities = 65/319 (20%), Positives = 148/319 (46%), Gaps = 28/319 (8%)
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY-KELDDECETCA 862
EN L KL+ + K + VI+ + S+L+ + S QQ +++LK + K L E A
Sbjct: 341 ENESL--KSKLEHANKENSDVIALWK-SKLETAIASHQQAMEELKVSFSKGLGTET---A 394
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV---ERQAKFADVAVNTDEDWANL 919
E+ + + + ++K +L + ++ NL+ Q +++ E +A A + E +L
Sbjct: 395 EFAELKTQ----IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 450
Query: 920 HSV--VVDRMSYDAEVEKNKRLMKTIE-ELRYKK-----QDLKNTVTKMQKAMEKYTKKD 971
++ +D+ VE L K E E++ +K ++ + MQ+ + K +K+
Sbjct: 451 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQRSMQETVNKLHQKE 510
Query: 972 KEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ-CKRLKEAKIALEIVD 1030
++F +LE + L +++ +++E DE E + ++ E + +K + +
Sbjct: 511 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 570
Query: 1031 KLSNQKVALEKQIE--SLSNTPVSNSTMYVATG---SAIVQNQQITDVMKENQKLKKMNA 1085
K++++ E+ +E L T + + ++ + Q + K++++ KK
Sbjct: 571 KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELE 630
Query: 1086 KLITICKKRGKTGANRENE 1104
+ ++ +K+ +T N+ E
Sbjct: 631 RKLSDLEKKMETSHNQCQE 649
Score = 37.1 bits (82), Expect = 0.35
Identities = 33/149 (22%), Positives = 70/149 (46%), Gaps = 10/149 (6%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY 95
+++ Q +K ++S I + + SL++S + + L + EL ++ + + L G
Sbjct: 829 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG-- 886
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN--- 152
E + L S +++LE + + + ++KNL LK ++++ DT ++
Sbjct: 887 -----ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDE 941
Query: 153 LIMENVTESDNLNKEVDDLKKNNECLTQK 181
E+ D LN + DL++ N+ L K
Sbjct: 942 RAQESQQMIDFLNSVIVDLQRKNQDLKMK 970
>AL365275-1|CAI40383.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 74.5 bits (175), Expect = 2e-12
Identities = 195/1014 (19%), Positives = 402/1014 (39%), Gaps = 85/1014 (8%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK----NLTDSLKTKSKK 139
I+ K A E + Q ++ ET+ + L Q KS E L ++I+ +L D +K K +
Sbjct: 69 IQALKDAHEEEIQQILAETREKIL---QYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 125
Query: 140 INELQEENDTLSNLIM----ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ E + + ++ + ++V +++EV+++++ E + L+ + E + +
Sbjct: 126 LTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQ-VQFEKDKR 184
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ +++ A + + IQ L + + +N+ + R ++ +L L+ R +
Sbjct: 185 LALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRM-EVESLNKMLEELRLE 240
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL---SEQ 312
K+L ED+ + L + +LD L + F ++++ E + +L E
Sbjct: 241 RKKLIEDY---EGKLNKAQSFYERELDT-LKRSQLFTAESLQASKEKEADLRKEFQGQEA 296
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK 372
++ K K + +D ++LD L + +N + Q LD+ E
Sbjct: 297 ILRKTIGKLKTELQMVQDEAGSLLDK---CQKLQTALAIAENNVQVLQKQLDDAKEGEMA 353
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
+ E SEL + E+L S L+ K + +L+ + + + +
Sbjct: 354 LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 413
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKL 490
L ++ + SK + Q L KK+ Y EL +E+E
Sbjct: 414 LSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 473
Query: 491 RLETGTAK-----------AVXXXXXXXXXXXXXXFDTLEEAHNEVK-SLHEELTKLYKS 538
+L +K A+ LEE HN+ K +L E+ +L +
Sbjct: 474 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE 533
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKM-------LSLSEKDNKL-TELVSTING 590
+ + + ++EI L+ + K+E+ + SL + +L EL T +
Sbjct: 534 LENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDS 593
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI------LMXXXXX 644
LKE ++L ++ + E+E Q E E + ++ ++DKM D+ +
Sbjct: 594 LKETKDALLNVEGEL--EQERQQHE-ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 650
Query: 645 XXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI-----NIKTHEKTAEIQ--- 696
++ KS + Q L LK++ + RD + ++ I ++ EIQ
Sbjct: 651 KLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQ 710
Query: 697 -NRMIMRLQKQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
+ +LQ Q QE +L E E + ++++LK + A + +E +E Q
Sbjct: 711 SQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEK-EQRAL 769
Query: 755 QKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL--GENP 812
+ L + AEL+S DE + +
Sbjct: 770 ENHLQQKHSAELQS------LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 823
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L+ +I ++ + +L + ++ +D + + KE E L+ R+
Sbjct: 824 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 883
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYD 930
+ L KE L + +S L +++ + + + R ++ + E N +D M+ D
Sbjct: 884 SELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTAD 943
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE---DCKAE 987
EKN +M+ + + LK +Q ++E+ +K E+K ++++ + KA
Sbjct: 944 HLREKN--IMRA--DFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAM 999
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
L E Q K+L E+ + L RE ++ + + +++ L+ QK +K
Sbjct: 1000 LTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDK 1053
Score = 48.0 bits (109), Expect = 2e-04
Identities = 105/543 (19%), Positives = 231/543 (42%), Gaps = 40/543 (7%)
Query: 521 AHNEVKSLHE-ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
A ++++ H E+ +L KS+ D ++A++N + +EE+ +++ ++ KML +
Sbjct: 186 ALEDLQAAHRREIQELLKSQQD-HSASVNKGQEKAEELHRMEV---ESLNKMLEELRLER 241
Query: 580 KLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK-MKADI 637
K +L+ G L + + + D + R + A L+ S K+ +L K +
Sbjct: 242 K--KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQAS----KEKEADLRKEFQGQE 295
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQ------NLALKE---QCEEKTRDCSRLEINIKT 688
+ DEA SLL++ LA+ E Q +K D ++ E +
Sbjct: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAK-EGEMAL 354
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
K E+++ + ++ Q+ L + K + + L +A + + +KDLES +
Sbjct: 355 LSKHKEVESELAAARERLQQQASDLVL-KASHIGML----QATQMTQEVTIKDLESEKSR 409
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
VN+ +Q + + + EQ + ++R
Sbjct: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLE 469
Query: 809 GENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELD-DLKERYKELDDECETCAEY 864
E +L+++ +++ ++ + + + +++L DL+E++ + E
Sbjct: 470 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 529
Query: 865 LQERDEQCARLKKEKLSL-EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
LQ+ E + ++KL+ Q++ +L++ +R E+ A+ + + +D
Sbjct: 530 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKS---EQGLGSAEGLIASLQDSQERLQNE 586
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME-KYTKKDKEFEAKRKE-- 980
+D ++ D+ E L+ EL ++Q + T+ M++ + K K + E K E
Sbjct: 587 LD-LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENL 645
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALE 1040
++C EEL+ +++E + + LK RE+ R K ++++++S K LE
Sbjct: 646 RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLE 705
Query: 1041 KQI 1043
Q+
Sbjct: 706 IQL 708
Score = 44.0 bits (99), Expect = 0.003
Identities = 51/226 (22%), Positives = 106/226 (46%), Gaps = 13/226 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+SE S++ ERL ++E L+ + + LD+E + L+++ + R ++E E+++
Sbjct: 404 ESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE--YYEREL 461
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
NL+ ++ E + + T E+ A H + ++ + +A +K K M E+
Sbjct: 462 KNLQSRLE-----EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQH 516
Query: 947 RYKKQDLKNTVTKMQKAME--KYTKKDKEFEAKRK--ELEDCKAELEELKQRYKELDEEC 1002
K +L+ ++Q+ +E K +DK A ++ L+D + E+ + L
Sbjct: 517 NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL 576
Query: 1003 ETCAEYLKQREEQCK-RLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
+ E L+ + K LKE K A L + +L ++ E+ I ++
Sbjct: 577 QDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Score = 40.7 bits (91), Expect = 0.028
Identities = 147/677 (21%), Positives = 270/677 (39%), Gaps = 83/677 (12%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
QSL E + L+LEK E +++ E K LE + L + K+LE
Sbjct: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAW 488
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE---- 176
I+ + + KK+ EE L +E + + L +E+++LK+ E
Sbjct: 489 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEE--DKNQLQQELENLKEVLEDKLN 546
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q+ L+ +V +SE +G E LI SL + ++L+ + DS
Sbjct: 547 TANQEIGHLQDMVRKSEQGLGS---------AEGLIASLQDSQERLQNELDLT-KDSLKE 596
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
T+ + + ++ EL+ R+ + E ++K +L M DL+ K EN E
Sbjct: 597 TK-DALLNVEGELEQERQQHE---ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQE---- 648
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
S+++ L +L + E KKS LL + D E + D ++ +++++
Sbjct: 649 --CSKLREEL-----RLQHEEDKKSA------MSQLLQLKDRE-KNAARDSWQKKVEDLL 694
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
N QI L L++ ++Q L++ + L+ + + +L ++ Q+ +
Sbjct: 695 N--QISL---LKQNLEIQ--LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 747
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ + + +++E E KE E + L+ +L AH++ F + Q
Sbjct: 748 KEAHVLAFQTMEEEKE-KEQRALE----NHLQQKHSAELQSLKDAHRESMEGFRIEMEQ- 801
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN-EVKSLHEELTKL 535
EL +E+E E G A + D L H+ E+ + EL +
Sbjct: 802 ELQTLRFELEDE------GKA-MLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERS 854
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
++ ++ I L EE+ ++ E +SE D ++ L I+ L +E
Sbjct: 855 IDISRRQSKEHICRITDLQEEL--------RHREH--HISELDKEVQHLHENISALTKE- 903
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
K + R + Q L + K+ ELD M AD L
Sbjct: 904 LEFKGKEILRIRSESNQQIRLHEQ-DLNKRLEKELDVMTADHLREKNIMRADFNKTNELL 962
Query: 656 DEAKSLLEQNLALKEQCEEK--TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E + L+ +L E+ EEK R+ +I + T K + I+ K++ ED+K
Sbjct: 963 KEINAALQVSL---EEMEEKYLMRESKPEDIQMITELKAMLTERDQII---KKLIEDNKF 1016
Query: 714 F----IEKETKLNELTN 726
+ + +ET N++ N
Sbjct: 1017 YQLELVNRETNFNKVFN 1033
Score = 36.3 bits (80), Expect = 0.61
Identities = 34/191 (17%), Positives = 84/191 (43%), Gaps = 5/191 (2%)
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR 874
+D + +I + D+ ++++ L ++++ K + E + + + L+ E +
Sbjct: 62 NDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTE-ELDLRRKIQVLESSLEDHIK 120
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
+K++ L+ + + E ++ + + ++ +E + + E
Sbjct: 121 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180
Query: 935 KNKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELEELK 992
K+KRL +E+L+ +++++ + Q K ++K E R E+E LEEL+
Sbjct: 181 KDKRL--ALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
Query: 993 QRYKELDEECE 1003
K+L E+ E
Sbjct: 239 LERKKLIEDYE 249
Score = 32.3 bits (70), Expect = 9.9
Identities = 26/109 (23%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 937 KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
K + K EL+ + + + + K QK + + +K+L+D K L ++K
Sbjct: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
E++ E E L+Q+ LK + I + +++ Q+V + K +ES
Sbjct: 360 EVESELAAARERLQQQASDLV-LKASHIGMLQATQMT-QEVTI-KDLES 405
>AL137009-1|CAI20344.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 74.5 bits (175), Expect = 2e-12
Identities = 195/1014 (19%), Positives = 402/1014 (39%), Gaps = 85/1014 (8%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK----NLTDSLKTKSKK 139
I+ K A E + Q ++ ET+ + L Q KS E L ++I+ +L D +K K +
Sbjct: 69 IQALKDAHEEEIQQILAETREKIL---QYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 125
Query: 140 INELQEENDTLSNLIM----ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ E + + ++ + ++V +++EV+++++ E + L+ + E + +
Sbjct: 126 LTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQ-VQFEKDKR 184
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ +++ A + + IQ L + + +N+ + R ++ +L L+ R +
Sbjct: 185 LALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRM-EVESLNKMLEELRLE 240
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL---SEQ 312
K+L ED+ + L + +LD L + F ++++ E + +L E
Sbjct: 241 RKKLIEDY---EGKLNKAQSFYERELDT-LKRSQLFTAESLQASKEKEADLRKEFQGQEA 296
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK 372
++ K K + +D ++LD L + +N + Q LD+ E
Sbjct: 297 ILRKTIGKLKTELQMVQDEAGSLLDK---CQKLQTALAIAENNVQVLQKQLDDAKEGEMA 353
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
+ E SEL + E+L S L+ K + +L+ + + + +
Sbjct: 354 LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 413
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKL 490
L ++ + SK + Q L KK+ Y EL +E+E
Sbjct: 414 LSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 473
Query: 491 RLETGTAK-----------AVXXXXXXXXXXXXXXFDTLEEAHNEVK-SLHEELTKLYKS 538
+L +K A+ LEE HN+ K +L E+ +L +
Sbjct: 474 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE 533
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKM-------LSLSEKDNKL-TELVSTING 590
+ + + ++EI L+ + K+E+ + SL + +L EL T +
Sbjct: 534 LENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDS 593
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI------LMXXXXX 644
LKE ++L ++ + E+E Q E E + ++ ++DKM D+ +
Sbjct: 594 LKETKDALLNVEGEL--EQERQQHE-ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 650
Query: 645 XXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI-----NIKTHEKTAEIQ--- 696
++ KS + Q L LK++ + RD + ++ I ++ EIQ
Sbjct: 651 KLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQ 710
Query: 697 -NRMIMRLQKQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
+ +LQ Q QE +L E E + ++++LK + A + +E +E Q
Sbjct: 711 SQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEK-EQRAL 769
Query: 755 QKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL--GENP 812
+ L + AEL+S DE + +
Sbjct: 770 ENHLQQKHSAELQS------LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 823
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L+ +I ++ + +L + ++ +D + + KE E L+ R+
Sbjct: 824 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 883
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYD 930
+ L KE L + +S L +++ + + + R ++ + E N +D M+ D
Sbjct: 884 SELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTAD 943
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE---DCKAE 987
EKN +M+ + + LK +Q ++E+ +K E+K ++++ + KA
Sbjct: 944 HLREKN--IMRA--DFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAM 999
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
L E Q K+L E+ + L RE ++ + + +++ L+ QK +K
Sbjct: 1000 LTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDK 1053
Score = 48.0 bits (109), Expect = 2e-04
Identities = 105/543 (19%), Positives = 231/543 (42%), Gaps = 40/543 (7%)
Query: 521 AHNEVKSLHE-ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
A ++++ H E+ +L KS+ D ++A++N + +EE+ +++ ++ KML +
Sbjct: 186 ALEDLQAAHRREIQELLKSQQD-HSASVNKGQEKAEELHRMEV---ESLNKMLEELRLER 241
Query: 580 KLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK-MKADI 637
K +L+ G L + + + D + R + A L+ S K+ +L K +
Sbjct: 242 K--KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQAS----KEKEADLRKEFQGQE 295
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQ------NLALKE---QCEEKTRDCSRLEINIKT 688
+ DEA SLL++ LA+ E Q +K D ++ E +
Sbjct: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAK-EGEMAL 354
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
K E+++ + ++ Q+ L + K + + L +A + + +KDLES +
Sbjct: 355 LSKHKEVESELAAARERLQQQASDLVL-KASHIGML----QATQMTQEVTIKDLESEKSR 409
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
VN+ +Q + + + EQ + ++R
Sbjct: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLE 469
Query: 809 GENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELD-DLKERYKELDDECETCAEY 864
E +L+++ +++ ++ + + + +++L DL+E++ + E
Sbjct: 470 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 529
Query: 865 LQERDEQCARLKKEKLSL-EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
LQ+ E + ++KL+ Q++ +L++ +R E+ A+ + + +D
Sbjct: 530 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKS---EQGLGSAEGLIASLQDSQERLQNE 586
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME-KYTKKDKEFEAKRKE-- 980
+D ++ D+ E L+ EL ++Q + T+ M++ + K K + E K E
Sbjct: 587 LD-LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENL 645
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALE 1040
++C EEL+ +++E + + LK RE+ R K ++++++S K LE
Sbjct: 646 RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLE 705
Query: 1041 KQI 1043
Q+
Sbjct: 706 IQL 708
Score = 44.0 bits (99), Expect = 0.003
Identities = 51/226 (22%), Positives = 106/226 (46%), Gaps = 13/226 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+SE S++ ERL ++E L+ + + LD+E + L+++ + R ++E E+++
Sbjct: 404 ESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE--YYEREL 461
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
NL+ ++ E + + T E+ A H + ++ + +A +K K M E+
Sbjct: 462 KNLQSRLE-----EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQH 516
Query: 947 RYKKQDLKNTVTKMQKAME--KYTKKDKEFEAKRK--ELEDCKAELEELKQRYKELDEEC 1002
K +L+ ++Q+ +E K +DK A ++ L+D + E+ + L
Sbjct: 517 NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL 576
Query: 1003 ETCAEYLKQREEQCK-RLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
+ E L+ + K LKE K A L + +L ++ E+ I ++
Sbjct: 577 QDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Score = 40.7 bits (91), Expect = 0.028
Identities = 147/677 (21%), Positives = 270/677 (39%), Gaps = 83/677 (12%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
QSL E + L+LEK E +++ E K LE + L + K+LE
Sbjct: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAW 488
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE---- 176
I+ + + KK+ EE L +E + + L +E+++LK+ E
Sbjct: 489 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEE--DKNQLQQELENLKEVLEDKLN 546
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q+ L+ +V +SE +G E LI SL + ++L+ + DS
Sbjct: 547 TANQEIGHLQDMVRKSEQGLGS---------AEGLIASLQDSQERLQNELDLT-KDSLKE 596
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
T+ + + ++ EL+ R+ + E ++K +L M DL+ K EN E
Sbjct: 597 TK-DALLNVEGELEQERQQHE---ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQE---- 648
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
S+++ L +L + E KKS LL + D E + D ++ +++++
Sbjct: 649 --CSKLREEL-----RLQHEEDKKSA------MSQLLQLKDRE-KNAARDSWQKKVEDLL 694
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
N QI L L++ ++Q L++ + L+ + + +L ++ Q+ +
Sbjct: 695 N--QISL---LKQNLEIQ--LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 747
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ + + +++E E KE E + L+ +L AH++ F + Q
Sbjct: 748 KEAHVLAFQTMEEEKE-KEQRALE----NHLQQKHSAELQSLKDAHRESMEGFRIEMEQ- 801
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN-EVKSLHEELTKL 535
EL +E+E E G A + D L H+ E+ + EL +
Sbjct: 802 ELQTLRFELEDE------GKA-MLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERS 854
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
++ ++ I L EE+ ++ E +SE D ++ L I+ L +E
Sbjct: 855 IDISRRQSKEHICRITDLQEEL--------RHREH--HISELDKEVQHLHENISALTKE- 903
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
K + R + Q L + K+ ELD M AD L
Sbjct: 904 LEFKGKEILRIRSESNQQIRLHEQ-DLNKRLEKELDVMTADHLREKNIMRADFNKTNELL 962
Query: 656 DEAKSLLEQNLALKEQCEEK--TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E + L+ +L E+ EEK R+ +I + T K + I+ K++ ED+K
Sbjct: 963 KEINAALQVSL---EEMEEKYLMRESKPEDIQMITELKAMLTERDQII---KKLIEDNKF 1016
Query: 714 F----IEKETKLNELTN 726
+ + +ET N++ N
Sbjct: 1017 YQLELVNRETNFNKVFN 1033
Score = 36.3 bits (80), Expect = 0.61
Identities = 34/191 (17%), Positives = 84/191 (43%), Gaps = 5/191 (2%)
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR 874
+D + +I + D+ ++++ L ++++ K + E + + + L+ E +
Sbjct: 62 NDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTE-ELDLRRKIQVLESSLEDHIK 120
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
+K++ L+ + + E ++ + + ++ +E + + E
Sbjct: 121 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180
Query: 935 KNKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELEELK 992
K+KRL +E+L+ +++++ + Q K ++K E R E+E LEEL+
Sbjct: 181 KDKRL--ALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
Query: 993 QRYKELDEECE 1003
K+L E+ E
Sbjct: 239 LERKKLIEDYE 249
Score = 32.3 bits (70), Expect = 9.9
Identities = 26/109 (23%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 937 KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
K + K EL+ + + + + K QK + + +K+L+D K L ++K
Sbjct: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
E++ E E L+Q+ LK + I + +++ Q+V + K +ES
Sbjct: 360 EVESELAAARERLQQQASDLV-LKASHIGMLQATQMT-QEVTI-KDLES 405
>AL132874-2|CAI42604.1| 1140|Homo sapiens chromosome 6 open reading
frame 60 protein.
Length = 1140
Score = 74.5 bits (175), Expect = 2e-12
Identities = 195/1014 (19%), Positives = 402/1014 (39%), Gaps = 85/1014 (8%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK----NLTDSLKTKSKK 139
I+ K A E + Q ++ ET+ + L Q KS E L ++I+ +L D +K K +
Sbjct: 69 IQALKDAHEEEIQQILAETREKIL---QYKSKVTEELDLRRKIQVLESSLEDHIKMKQQA 125
Query: 140 INELQEENDTLSNLIM----ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ E + + ++ + ++V +++EV+++++ E + L+ + E + +
Sbjct: 126 LTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQ-VQFEKDKR 184
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ +++ A + + IQ L + + +N+ + R ++ +L L+ R +
Sbjct: 185 LALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEELHRM-EVESLNKMLEELRLE 240
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL---SEQ 312
K+L ED+ + L + +LD L + F ++++ E + +L E
Sbjct: 241 RKKLIEDY---EGKLNKAQSFYERELDT-LKRSQLFTAESLQASKEKEADLRKEFQGQEA 296
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK 372
++ K K + +D ++LD L + +N + Q LD+ E
Sbjct: 297 ILRKTIGKLKTELQMVQDEAGSLLDK---CQKLQTALAIAENNVQVLQKQLDDAKEGEMA 353
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
+ E SEL + E+L S L+ K + +L+ + + + +
Sbjct: 354 LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 413
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDYEIEKEKL 490
L ++ + SK + Q L KK+ Y EL +E+E
Sbjct: 414 LSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 473
Query: 491 RLETGTAK-----------AVXXXXXXXXXXXXXXFDTLEEAHNEVK-SLHEELTKLYKS 538
+L +K A+ LEE HN+ K +L E+ +L +
Sbjct: 474 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE 533
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKM-------LSLSEKDNKL-TELVSTING 590
+ + + ++EI L+ + K+E+ + SL + +L EL T +
Sbjct: 534 LENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDS 593
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI------LMXXXXX 644
LKE ++L ++ + E+E Q E E + ++ ++DKM D+ +
Sbjct: 594 LKETKDALLNVEGEL--EQERQQHE-ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 650
Query: 645 XXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI-----NIKTHEKTAEIQ--- 696
++ KS + Q L LK++ + RD + ++ I ++ EIQ
Sbjct: 651 KLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQ 710
Query: 697 -NRMIMRLQKQI-QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
+ +LQ Q QE +L E E + ++++LK + A + +E +E Q
Sbjct: 711 SQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEK-EQRAL 769
Query: 755 QKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL--GENP 812
+ L + AEL+S DE + +
Sbjct: 770 ENHLQQKHSAELQS------LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 823
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L+ +I ++ + +L + ++ +D + + KE E L+ R+
Sbjct: 824 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 883
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFADVAVNTDEDWANLH-SVVVDRMSYD 930
+ L KE L + +S L +++ + + + R ++ + E N +D M+ D
Sbjct: 884 SELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTAD 943
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE---DCKAE 987
EKN +M+ + + LK +Q ++E+ +K E+K ++++ + KA
Sbjct: 944 HLREKN--IMRA--DFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAM 999
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
L E Q K+L E+ + L RE ++ + + +++ L+ QK +K
Sbjct: 1000 LTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDK 1053
Score = 48.0 bits (109), Expect = 2e-04
Identities = 105/543 (19%), Positives = 231/543 (42%), Gaps = 40/543 (7%)
Query: 521 AHNEVKSLHE-ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
A ++++ H E+ +L KS+ D ++A++N + +EE+ +++ ++ KML +
Sbjct: 186 ALEDLQAAHRREIQELLKSQQD-HSASVNKGQEKAEELHRMEV---ESLNKMLEELRLER 241
Query: 580 KLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK-MKADI 637
K +L+ G L + + + D + R + A L+ S K+ +L K +
Sbjct: 242 K--KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQAS----KEKEADLRKEFQGQE 295
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQ------NLALKE---QCEEKTRDCSRLEINIKT 688
+ DEA SLL++ LA+ E Q +K D ++ E +
Sbjct: 296 AILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAK-EGEMAL 354
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
K E+++ + ++ Q+ L + K + + L +A + + +KDLES +
Sbjct: 355 LSKHKEVESELAAARERLQQQASDLVL-KASHIGML----QATQMTQEVTIKDLESEKSR 409
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
VN+ +Q + + + EQ + ++R
Sbjct: 410 VNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLE 469
Query: 809 GENPKLDDSPKRSISVIS---DSEVSQLKERLLSCQQELD-DLKERYKELDDECETCAEY 864
E +L+++ +++ ++ + + + +++L DL+E++ + E
Sbjct: 470 EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQ 529
Query: 865 LQERDEQCARLKKEKLSL-EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
LQ+ E + ++KL+ Q++ +L++ +R E+ A+ + + +D
Sbjct: 530 LQQELENLKEVLEDKLNTANQEIGHLQDMVRKS---EQGLGSAEGLIASLQDSQERLQNE 586
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME-KYTKKDKEFEAKRKE-- 980
+D ++ D+ E L+ EL ++Q + T+ M++ + K K + E K E
Sbjct: 587 LD-LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENL 645
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALE 1040
++C EEL+ +++E + + LK RE+ R K ++++++S K LE
Sbjct: 646 RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLE 705
Query: 1041 KQI 1043
Q+
Sbjct: 706 IQL 708
Score = 44.0 bits (99), Expect = 0.003
Identities = 51/226 (22%), Positives = 106/226 (46%), Gaps = 13/226 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+SE S++ ERL ++E L+ + + LD+E + L+++ + R ++E E+++
Sbjct: 404 ESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE--YYEREL 461
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
NL+ ++ E + + T E+ A H + ++ + +A +K K M E+
Sbjct: 462 KNLQSRLE-----EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQH 516
Query: 947 RYKKQDLKNTVTKMQKAME--KYTKKDKEFEAKRK--ELEDCKAELEELKQRYKELDEEC 1002
K +L+ ++Q+ +E K +DK A ++ L+D + E+ + L
Sbjct: 517 NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL 576
Query: 1003 ETCAEYLKQREEQCK-RLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
+ E L+ + K LKE K A L + +L ++ E+ I ++
Sbjct: 577 QDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Score = 40.7 bits (91), Expect = 0.028
Identities = 147/677 (21%), Positives = 270/677 (39%), Gaps = 83/677 (12%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
QSL E + L+LEK E +++ E K LE + L + K+LE
Sbjct: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAW 488
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE---- 176
I+ + + KK+ EE L +E + + L +E+++LK+ E
Sbjct: 489 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEE--DKNQLQQELENLKEVLEDKLN 546
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
Q+ L+ +V +SE +G E LI SL + ++L+ + DS
Sbjct: 547 TANQEIGHLQDMVRKSEQGLGS---------AEGLIASLQDSQERLQNELDLT-KDSLKE 596
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
T+ + + ++ EL+ R+ + E ++K +L M DL+ K EN E
Sbjct: 597 TK-DALLNVEGELEQERQQHE---ETIAAMKEEEKLKVDKMAHDLEIKWTENLRQE---- 648
Query: 297 KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
S+++ L +L + E KKS LL + D E + D ++ +++++
Sbjct: 649 --CSKLREEL-----RLQHEEDKKSA------MSQLLQLKDRE-KNAARDSWQKKVEDLL 694
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
N QI L L++ ++Q L++ + L+ + + +L ++ Q+ +
Sbjct: 695 N--QISL---LKQNLEIQ--LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 747
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY 476
+ + + +++E E KE E + L+ +L AH++ F + Q
Sbjct: 748 KEAHVLAFQTMEEEKE-KEQRALE----NHLQQKHSAELQSLKDAHRESMEGFRIEMEQ- 801
Query: 477 ELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN-EVKSLHEELTKL 535
EL +E+E E G A + D L H+ E+ + EL +
Sbjct: 802 ELQTLRFELEDE------GKA-MLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERS 854
Query: 536 YKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEEN 595
++ ++ I L EE+ ++ E +SE D ++ L I+ L +E
Sbjct: 855 IDISRRQSKEHICRITDLQEEL--------RHREH--HISELDKEVQHLHENISALTKE- 903
Query: 596 NSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
K + R + Q L + K+ ELD M AD L
Sbjct: 904 LEFKGKEILRIRSESNQQIRLHEQ-DLNKRLEKELDVMTADHLREKNIMRADFNKTNELL 962
Query: 656 DEAKSLLEQNLALKEQCEEK--TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
E + L+ +L E+ EEK R+ +I + T K + I+ K++ ED+K
Sbjct: 963 KEINAALQVSL---EEMEEKYLMRESKPEDIQMITELKAMLTERDQII---KKLIEDNKF 1016
Query: 714 F----IEKETKLNELTN 726
+ + +ET N++ N
Sbjct: 1017 YQLELVNRETNFNKVFN 1033
Score = 36.3 bits (80), Expect = 0.61
Identities = 34/191 (17%), Positives = 84/191 (43%), Gaps = 5/191 (2%)
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR 874
+D + +I + D+ ++++ L ++++ K + E + + + L+ E +
Sbjct: 62 NDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTE-ELDLRRKIQVLESSLEDHIK 120
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
+K++ L+ + + E ++ + + ++ +E + + E
Sbjct: 121 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180
Query: 935 KNKRLMKTIEELRYK-KQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELEELK 992
K+KRL +E+L+ +++++ + Q K ++K E R E+E LEEL+
Sbjct: 181 KDKRL--ALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 238
Query: 993 QRYKELDEECE 1003
K+L E+ E
Sbjct: 239 LERKKLIEDYE 249
Score = 32.3 bits (70), Expect = 9.9
Identities = 26/109 (23%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 937 KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
K + K EL+ + + + + K QK + + +K+L+D K L ++K
Sbjct: 300 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 359
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
E++ E E L+Q+ LK + I + +++ Q+V + K +ES
Sbjct: 360 EVESELAAARERLQQQASDLV-LKASHIGMLQATQMT-QEVTI-KDLES 405
>AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein.
Length = 948
Score = 74.5 bits (175), Expect = 2e-12
Identities = 92/495 (18%), Positives = 203/495 (41%), Gaps = 19/495 (3%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
+N ++ ++K ++ ++ + LKE K + + L
Sbjct: 435 FMKN--KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL 492
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
+ + E + M+ + KQIQ+ + + ++++L + + +R + K +
Sbjct: 493 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 552
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E+ +E + Q ++ R+ L++D TA
Sbjct: 553 ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 612
Query: 803 DENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
E ++ +N K D K +S++ ++S+ + LL ++ L + D +T
Sbjct: 613 REKQEEIDNYKKDLKDLKEKVSLL-QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 671
Query: 862 AEYLQERDEQCARL-----KKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFADVAVNTDED 915
L+++ E+C ++ K + +LE + S E Q +ER+ ++ D + +
Sbjct: 672 EIALEQKKEECLKMESQLKKAHEAALEARAS--PEMSDRIQHLEREITRYKDESSKAQAE 729
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L ++ + + + +K ++++ + K Q+ K K ++ +EK E
Sbjct: 730 VDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEE 789
Query: 976 AKRKE--LEDCKAEL--EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
A+R+E L D +L EEL +++ +E E+ L ++ KE + ++
Sbjct: 790 ARRREDNLNDSSQQLQVEELLMAMEKVKQELESMKAKLSSTQQSLAE-KETHLTNLRAER 848
Query: 1032 LSNQKVALEKQIESL 1046
+ + LE + E+L
Sbjct: 849 RKHLEEVLEMKQEAL 863
Score = 63.7 bits (148), Expect = 4e-09
Identities = 150/715 (20%), Positives = 300/715 (41%), Gaps = 71/715 (9%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
I+ N + QDS + T + + +E+ ++ + E+ + ELF +++ +E + +
Sbjct: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET 297
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN 157
+ QT + IK L +E L T+ +++++ E + L +L+ +
Sbjct: 298 ---QKQTLNARDESIKKL-LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
Query: 158 VTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHI 217
E+ L +E+ + N + K L+ ++ ++KI + L+E +
Sbjct: 354 EKENSMLREEM-HRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR-DLEEEIQMLKSN 411
Query: 218 GYDNTLSK----LNRSISDSNTSTRYNKICTLQSELD-------AGREDCKELCEDFTSI 266
G +T + + S++ NKI ++ EL A + + L F+
Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS 471
Query: 267 KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID 326
K H+E+ + ++T E+ + E A+++ E K E ++N ++K+ +D +
Sbjct: 472 KQHIEVLKESLT--AKEQRAAILQTEVDALRLRLEEK-------ETMLNKKTKQIQDMAE 522
Query: 327 RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELK- 385
+ D + LDV E + N++ K +L E L K L E L+
Sbjct: 523 EKGTQAGEIHDLK---DMLDVKERKV-NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQA 578
Query: 386 ---SVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE-NELKEILTKEC 441
+ + L +L L EKE L+ Q++R E ID KK+ +LKE ++
Sbjct: 579 DTTNTDTALTTLEEALAEKERTIERLKEQRDR-DEREKQEEIDNYKKDLKDLKEKVSLLQ 637
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVX 501
LS+ + + DL + + + D+ + E++ + ++E L++E+ KA
Sbjct: 638 GDLSEKEASL-LDLKEHASSLASSGLKKDSRLKTLEIALE--QKKEECLKMESQLKKA-- 692
Query: 502 XXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD---------ENNANLNLIKI 552
D ++ E+ +E +K +++VD EN N KI
Sbjct: 693 HEAALEARASPEMSDRIQHLEREITRYKDESSKA-QAEVDRLLEILKEVENEKNDKDKKI 751
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQ 612
E+++L K++ K ++ + K + E + L+E +LND ++ Q
Sbjct: 752 --AELESLTSRQVKDQNKKVA-NLKHKEQVEKKKSAQMLEEARRREDNLND---SSQQLQ 805
Query: 613 ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC 672
EL + + +KQ EL+ MKA + E + LE+ L +K++
Sbjct: 806 VEELLMAMEKVKQ---ELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 862
Query: 673 -----EEKTRDCSRLEINI---KTHEKTAEI---QNRMIMRLQKQIQEDDKLFIE 716
EK + + LE++ KT E+ A + ++R++ +L++Q Q KL +
Sbjct: 863 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 917
>AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1007
Score = 74.1 bits (174), Expect = 2e-12
Identities = 198/1055 (18%), Positives = 420/1055 (39%), Gaps = 101/1055 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR----DLLMSQIKSLEME 118
++ S + ++E+L + D+ ++K +LE + + L Q R D + ++SL M
Sbjct: 14 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESL-MT 72
Query: 119 NLTKDKEIKN---LTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
L +K +K+ + D ++ K + + + E L+ E +E ++V L
Sbjct: 73 ELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKVCLLVVWG 132
Query: 176 ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SN 234
+EK + + + ++ + + + + D L L D
Sbjct: 133 VSSVWTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQ 192
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFET 293
+ +I +++ A ++ DF + E L E + D ++ E NE
Sbjct: 193 HKIKQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDIEMAERNEDHH 246
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
V SE+ Q E +K K + + + AVLD + G ++ L+
Sbjct: 247 LQVLKESEVLL-------QAKRAELEKLKSQVTSQQQEM-AVLDRQLGHKKEELH--LLQ 296
Query: 354 NIINKYQIDLDEILE----KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
+ + + DL E L + T+ + E S L+ ++ + LN Q+ E++ +++
Sbjct: 297 GSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIK 356
Query: 410 IQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILF 469
+ E+ E V + K + ELK IL + L+L ++ + + +
Sbjct: 357 QEIEKEEENLQVVLRQMSKHKTELKNIL--DMLQLENHEL-------------QGLKLQH 401
Query: 470 DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT--LEEAHNEVKS 527
D ++ EL +T + +EKL LE + D +E E ++
Sbjct: 402 DQRVS--ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRA 459
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
L + L K K D L E+ D + +A+ + ++L+ +E+++K+ + S
Sbjct: 460 LQSCVECLSKEKED-----------LQEKCDIWEKKLAQTK-RVLAAAEENSKMEQ--SN 505
Query: 588 INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
+ L+ L+ D + R+K + +++ Q +++ ++ ++ ++
Sbjct: 506 LEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL------ANVQ 559
Query: 648 XXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQI 707
D + Q++ L EQ + +D S + +K E + + + LQ +I
Sbjct: 560 DHLNLAKQDLLHTTKHQDVLLSEQTRLQ-KDISEWANRFEDCQKEEETKQQQLQVLQNEI 618
Query: 708 QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREAVNQLTTQK---DLVEGRI 763
+E+ +++E L + E+ + + + L E + +LT QK D V ++
Sbjct: 619 EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV 678
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
E +RT Q +++ +L K DS + S
Sbjct: 679 LAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS 738
Query: 824 VI----------SDSEVSQLKERLLSCQQELD-DLKERYKE---LDDECETCAEYLQERD 869
++ ++ +V+ LKE L + +L+ +L E+ +E + E T Q+
Sbjct: 739 LLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNH 798
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RM 927
E+ RL KE ++ + + LK+Q+ Q+ +ER+ A+ T L S V D R
Sbjct: 799 ERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRT------LKSEVKDEIRT 852
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S + L +E + + ++L+ + +++ + +T + FE K L +
Sbjct: 853 SLKNLNQFLPELPADLEAILERNENLEGELESLKENL-PFTMNEGPFEEK---LNFSQVH 908
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLS 1047
+ + R + L E+ + LK + C K+A++ ++ + +L +Q+++L
Sbjct: 909 IMDEHWRGEALREKLRHREDRLKAQLRHCMS-KQAEVLIKGKRQTEGTLHSLRRQVDALG 967
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
S S ++ S +T+ + Q +K
Sbjct: 968 ELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEK 1002
Score = 53.2 bits (122), Expect = 5e-06
Identities = 101/547 (18%), Positives = 211/547 (38%), Gaps = 35/547 (6%)
Query: 551 KILSEEI--DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE 608
KI EEI + KI AK+ + LS+K KLTE E L+ ++ R
Sbjct: 194 KIKQEEILKEINKIVAAKDSD-FQCLSKKKEKLTE----------ELQKLQKDIEMAERN 242
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
++ L+ S +++ EL+K+K+ + +E L +
Sbjct: 243 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 302
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
K +E R E+ K + E+++ ++ L Q E + E++T+L + +
Sbjct: 303 KADLQEALR-LGETEVTEKCNH-IREVKS-LLEELSFQKGELNVQISERKTQLTLIKQEI 359
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
E + + ++ + + + + D+++ EL+ ++ + V
Sbjct: 360 EKEEENLQVVLRQMSKHKTELKNIL---DMLQLENHELQG-LKLQHDQRVSELEKTQVAV 415
Query: 789 XXXXXXXXXXXTFGDENR-DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + ++ +L + KR I ++ L SC + L
Sbjct: 416 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE-----RMTAESRALQSCVECLSKE 470
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
KE +L ++C+ + L + A ++ + + L+ +R Q Q
Sbjct: 471 KE---DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 527
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKY 967
++++ D A + R + ++ E+ L + L KQDL +T + +
Sbjct: 528 LSLHNDIS-AMQQQLQEKREAVNSLQEE---LANVQDHLNLAKQDLLHTTKHQDVLLSEQ 583
Query: 968 TKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
T+ K+ EDC+ E E +Q+ + L E E L Q+E +RL++ + + E
Sbjct: 584 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEE 643
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
KL KV L++Q L + S ++ ++ ++E ++ + K
Sbjct: 644 --SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 701
Query: 1088 ITICKKR 1094
++ K++
Sbjct: 702 LSQTKRQ 708
Score = 47.6 bits (108), Expect = 2e-04
Identities = 148/768 (19%), Positives = 311/768 (40%), Gaps = 59/768 (7%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSG--TITISCKMCQSLKE-SSNEINLKLEKLSGE 80
+N ++ ++++T+S+ +L+ T K Q L+ ++ +L+ K+ E
Sbjct: 139 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE 198
Query: 81 --LFDIKEQKSALEGKYQNLILETQ--TRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
L +I + +A + +Q L + + T +L Q K +EM +D ++ L +S
Sbjct: 199 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ-KDIEMAERNEDHHLQVLKESEVLL 257
Query: 137 SKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
K EL++ +++ E L + ++L + Q DL++ + E ++
Sbjct: 258 QAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEV 317
Query: 197 GPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDC 256
K C + ++L++ L +LN IS+ T K ++ E + +
Sbjct: 318 TEK--CNHIREVKSLLEELSF----QKGELNVQISERKTQLTLIK-QEIEKEEENLQVVL 370
Query: 257 KELCEDFTSIKN-----HLELHE-PNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
+++ + T +KN LE HE + + D+++ E + + ++ E++ NL +S
Sbjct: 371 RQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELE-NLQQIS 429
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
+Q E + K ++R K + + AE V + + + + D+ E
Sbjct: 430 QQQ-KGEIEWQKQLLERDKRE-IERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQ 487
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
TK E S+++ N + LN + +++E + L K +H SA+ + +K
Sbjct: 488 TKRVLAAAEENSKMEQSNLEKLELNVRKLQQE--LDQLNRDKLSLHNDISAMQQQLQEKR 545
Query: 431 ---NELKEILTKECLKLSKLKIDIPRDL-DQDLPAHKKITILFDALITQYELSRTDYEIE 486
N L+E L L+ K D+ QD+ ++ + D I+++ D + E
Sbjct: 546 EAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKD--ISEWANRFEDCQKE 603
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
+E + + + F L+ K E +KL SKV
Sbjct: 604 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ------KERESEESKLETSKVTLKEQQ 657
Query: 547 LNLIKILSEE---IDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLND 603
L K L+++ +D + + EE++ +L E++ L T++ K +
Sbjct: 658 HQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQ--------- 708
Query: 604 VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLE 663
E+E Q E +++ E D M+AD + K L+
Sbjct: 709 --LSEREQQLVEKSGELLALQK---EADSMRADFSLLRNQFLTERKKAEKQVASLKEALK 763
Query: 664 -QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
Q L++ E+ ++ S ++ + T E A+ + RL K++ + + E + ++
Sbjct: 764 IQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMA 823
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI 770
E + + A++ L+S E +++ T + + EL +D+
Sbjct: 824 N-QKDLERRQMEISDAMRTLKS--EVKDEIRTSLKNLNQFLPELPADL 868
>X64838-1|CAA46050.1| 1427|Homo sapiens restin protein.
Length = 1427
Score = 73.7 bits (173), Expect = 3e-12
Identities = 126/634 (19%), Positives = 253/634 (39%), Gaps = 36/634 (5%)
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
T F L TQ E R DY+ E E L+ + + +A ++E N +
Sbjct: 642 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL--MKVIKEKENSL 699
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+++ +L K + E LN ++ ++ L++ AK E+ + DN ++L
Sbjct: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI---DNFTSQLK 756
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+T L + + K+ ++ + K+ + +LE + + IK E++K
Sbjct: 757 ATEEKLLDLDALRKASSEGKSEMKKLR-QQLEAAEKQIKH--LEIEKN------AESSKA 807
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
+ + L++NL+ Q +E E+ I EK AE + +Q+
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEK----ELQI-LKEKFAEASEEAVS-VQR 861
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAE 765
+QE +KE + N L++ E L+ + E QL K+ +E IAE
Sbjct: 862 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 921
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-----DSPKR 820
+ + + ++ + T +EN + D + ++
Sbjct: 922 I-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE-TCAEYLQERDEQCARLKKEK 879
+ + E +L+ +L +++++ + +EL E +E + +E L+K
Sbjct: 981 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 880 LSLEQQVSNLKEQ----IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
L E ++ +E+ ++ + + +QA A A ++ + + ++ A +E
Sbjct: 1041 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1100
Query: 936 NKRL-MKTIEEL-RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQ 993
K+ K EL K+ +LKN V ++ K+ E T ++++ E RKE+E K + Q
Sbjct: 1101 TKQTNAKLQNELDTLKENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1159
Query: 994 RYKELDEECETCAEYL-KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
+ L EE AE L + R+E K + + ++L K K I+ S
Sbjct: 1160 QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1219
Query: 1053 NSTMYVATGSAIVQ-NQQITDVMKENQKLKKMNA 1085
T + + + + ++ + E L+ NA
Sbjct: 1220 LQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1253
Score = 73.3 bits (172), Expect = 4e-12
Identities = 177/975 (18%), Positives = 400/975 (41%), Gaps = 82/975 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME-NLT 121
L E+S+ K+ + +KE++ +E LE S + +E E L
Sbjct: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALA 395
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDL--KKNNECLT 179
+D +++ + L+ K ++ + E D ++ + E ++V+DL + E +T
Sbjct: 396 RDGHDQHVLE-LEAKMDQLRTMVEAADREKVELLNQLEEE---KRKVEDLQFRVEEESIT 451
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS-DSNTSTR 238
+ ++ + + + K +++ + + L + L T+S+ +R + + + + R
Sbjct: 452 KGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALR 511
Query: 239 YNKICTLQSELD----AGREDCK-ELCEDFTSIKNHLEL----HEPNMTMDLDEKLGENN 289
++ L+ L+ AG D L ++ +S++ LE+ H+ +T L E G
Sbjct: 512 VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT-SLKEHFGARE 570
Query: 290 EFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
E K +K + L+ +E L + + +K++ D I +K L + + +++
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH--QQAME 628
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
++ + + E+ + K++ D L++ + + +++ +E A
Sbjct: 629 ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRA-K 687
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
++++ KE+ + + A+ + K E++ + KL + +I + ++L+ + T
Sbjct: 688 LMKVIKEKENSLE-AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV-KELEVLQAKCNEQT 745
Query: 467 ILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
+ D +Q + + ++ + LR + K+ LE N
Sbjct: 746 KVIDNFTSQLKATEEKL-LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804
Query: 527 SLHEELTK------LYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLS----LS 575
S +T+ L + + EN + ++ +K L +E+ LK A+ E+ +S +
Sbjct: 805 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 864
Query: 576 EKDNKLTELVSTINGLKEENNSLK-SLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E NKL + N L + L+ +L D+ + +E ER Q+IK +K++
Sbjct: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD----EREEQLIKAK----EKLE 916
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA-LKEQCEEKTRDCSRLEINIKTHEKTA 693
DI DE + L E+++ L+ + + + S L+ +I+ A
Sbjct: 917 NDIAEIMKMSGDNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKA 975
Query: 694 E-IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E Q + +++ +E ++ + E K+ N+ + LK Y+ A + ++ E + Q
Sbjct: 976 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ- 1034
Query: 753 TTQKDLV--EGRI--AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
QK L+ E ++ A E+ ++ + E +
Sbjct: 1035 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET 1094
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-------RYKELDDECETC 861
+ L+D+ + + + +E+ LKE L +EL+ KE + +E E ET
Sbjct: 1095 LAS--LEDTKQTNAKL--QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV----------- 910
+ ++ +Q + L++E + L +++ ++++ + Q +E + + +
Sbjct: 1151 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1210
Query: 911 -NTDEDWANLHSVVVDRMSY----DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
+ DE+ A+L + + DAE+EK + + + + L + V ++
Sbjct: 1211 KDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKV 1270
Query: 966 KYTKKDKEFEAKRKE 980
K K K E + KE
Sbjct: 1271 KLELKVKNLELQLKE 1285
Score = 72.5 bits (170), Expect = 8e-12
Identities = 148/738 (20%), Positives = 304/738 (41%), Gaps = 66/738 (8%)
Query: 54 TISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQI 112
++ K+ + KE+S+ I L KL + ++ L+ + + L ET L +QI
Sbjct: 593 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 652
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ + ++ + + ++N DS + K E++ L +I E + + ++D K
Sbjct: 653 EKMRLDYQHEIENLQNQQDSERAAHAK--EMEALRAKLMKVIKEKENSLEAIRSKLD--K 708
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNIC-AQCKLKENLIQSLHIGYDNTLSKL-NRSI 230
++ L + L KL E+E K+ + A+C + +I + T KL +
Sbjct: 709 AEDQHLVEMEDTLNKL-QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 767
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKEL-------CEDFTSIKNHLELHEPNMTMDLDE 283
+S +++ L+ +L+A + K L +SI L+ E +T +L E
Sbjct: 768 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT-NLQE 826
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
L E ++ + K + +K SE+ ++ + + ++ +++ + +F
Sbjct: 827 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ-RSMQETVNKLHQK-----EEQFNML 880
Query: 344 SLDVFEILMDNIIN---KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
S D+ E L +N+ + K++ + DE E+ K + L +E+ K++ NS +
Sbjct: 881 SSDL-EKLRENLADMEAKFR-EKDEREEQLIKAKEKLENDIAEIM----KMSGDNSSQLT 934
Query: 401 KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLP 460
K N + LR+++ + E+ +T K NE L K + + + + +
Sbjct: 935 KMN--DELRLKERDVEELQLKLT-----KANENASFLQKS---IEDMTVKAEQSQQEAAK 984
Query: 461 AHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
H++ + EL R ++EK ++ET + E
Sbjct: 985 KHEE---------EKKELERKLSDLEK---KMETSHNQCQELKARYERATSETKTKHEEI 1032
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
N K+L + KL K +EN+ L ++ L ++ D K A E+ M + + +
Sbjct: 1033 LQNLQKTLLDTEDKL-KGAREENSGLLQELEELRKQADKAKAAQTA-EDAMQIMEQMTKE 1090
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
TE ++++ K+ N L++ D + EL +S +++ ++++ + +I
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQ------NLALKEQCEEKTRDCSRLEINIKTHE-KTA 693
+E L E+ + ++ EE+ + + +K E K
Sbjct: 1151 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1210
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ + LQK I L EK+ +L +L N+ L R +A+ K L S V L
Sbjct: 1211 KDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL-RGENASAKSLHS---VVQTLE 1266
Query: 754 TQKDLVEGRIAELESDIR 771
+ K +E ++ LE ++
Sbjct: 1267 SDKVKLELKVKNLELQLK 1284
Score = 65.7 bits (153), Expect = 9e-10
Identities = 155/769 (20%), Positives = 298/769 (38%), Gaps = 66/769 (8%)
Query: 28 DGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQ 87
+ KSK ++ + S+ I L S T Q+++E + L + E ++K Q
Sbjct: 592 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD-----KEIKNLTDSLKTKSKKINE 142
+ YQ+ I Q + + EME L KE +N +++++K K +
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 711
Query: 143 --LQEENDTLSNLIMENV---------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVN- 190
L E DTL+ L + + + K +D+ + +K +DL+ L
Sbjct: 712 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 771
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
SE K K + Q + E I+ L I + N S +++ TR EL
Sbjct: 772 SSEGKSEMKKLRQQLEAAEKQIKHLEI-------EKNAESSKASSITR---------ELQ 815
Query: 251 AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
L E+ + + E E + + L EK E +E +AV V ++ +N L
Sbjct: 816 GRELKLTNLQENLSEVSQVKETLEKELQI-LKEKFAEASE---EAVSVQRSMQETVNKLH 871
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
++ + +++ +++ LA ++A+F D E + K + D+ EI++
Sbjct: 872 QK--EEQFNMLSSDLEKLREN-LADMEAKF--REKDEREEQLIKAKEKLENDIAEIMKMS 926
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L + EL+ + L +L + + L+ E + + + KK
Sbjct: 927 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 986
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPA-HKKIT----ILFDALITQYELSRTDYEI 485
E K+ L ++ L K K++ + Q+L A +++ T + ++ + + D E
Sbjct: 987 EEEKKELERKLSDLEK-KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE- 1044
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+K K E + T E+A ++ + +E T+ S D
Sbjct: 1045 DKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1104
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNSLKSL 601
N L E+D LK KN E++ L+ ++ K+ E I LK+
Sbjct: 1105 NAK----LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1160
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ E A EL RS + + +L++ ++ + DE K+
Sbjct: 1161 LSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1219
Query: 662 LEQNLALKEQ-CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
L++++++ EK + +L E+ + E + ++ Q E DK+ +E +
Sbjct: 1220 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV----QTLESDKVKLELK 1275
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
K EL K + + D ++ + Q +Q D + I +L+
Sbjct: 1276 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQ-ESQIDFLNSVIVDLQ 1323
Score = 64.9 bits (151), Expect = 2e-09
Identities = 124/613 (20%), Positives = 267/613 (43%), Gaps = 59/613 (9%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R++LD K+++ +++E + KLQ++ I K + L+ NE ++ + +L
Sbjct: 703 RSKLD--KAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 84 IKEQ--------KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
+E+ K++ EGK + L Q + QIK LE+E + + ++T L+
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAESSKASSITRELQG 816
Query: 136 KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ K+ LQE +S + + L KE+ LK+ +++ + +++ + E+ NK
Sbjct: 817 RELKLTNLQENLSEVSQV-------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 869
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ K + + N++ S L KL +++D ++ + + +L +E
Sbjct: 870 LHQK------EEQFNMLSS-------DLEKLRENLAD--MEAKFREKDEREEQLIKAKEK 914
Query: 256 CKELCEDFTSIK--NHLELHEPNMTMDLDEKLGENNEFE-TKAVKVMSEIKRNLNSLSEQ 312
+ + + N +L + N + L E+ E + + TKA + S +++++ ++ +
Sbjct: 915 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 974
Query: 313 LINNESKKSKDHIDRYK--DSLLAVLDAEFGTTSLDVFEI--LMDNIINKYQIDLDEILE 368
++ + +K H + K + L+ L+ + T+ E+ + ++ + +EIL+
Sbjct: 975 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 1034
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
+Q L + +LK E+ + L +L E + + + + E + + + K
Sbjct: 1035 ---NLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD--KAKAAQTAEDAMQIMEQMTK 1089
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
++ E L +KL+ ++ + +L +++ + L + + E KE
Sbjct: 1090 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME---EFRKE 1146
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS---LHEELTKLYKSKVDENNA 545
L+ A+ + L + +EV S L EE + L ++
Sbjct: 1147 IETLKQAAAQK-SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1205
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
IK EE +L+ +I+ L+EKD +L +L + + L+ EN S KSL+ V+
Sbjct: 1206 ESKFIKDADEEKASLQKSISITS---ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV 1262
Query: 606 -TREKETQASELE 617
T E + EL+
Sbjct: 1263 QTLESDKVKLELK 1275
Score = 47.6 bits (108), Expect = 2e-04
Identities = 104/590 (17%), Positives = 244/590 (41%), Gaps = 47/590 (7%)
Query: 530 EELTKLYKSKVDENNANLNLIKI----LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
E TKL +++ E +L K L E++ ++A + +++ L EKD L V
Sbjct: 456 ETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMEL-EKDLALR--V 512
Query: 586 STINGLKEENNSLKSLNDV-ITREKETQASELERSCQVIK-QNGFELDKMKADILMXXXX 643
+ L+ S K DV ++ + S L+ +V + + E+ +K
Sbjct: 513 QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREET 572
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
++ L ++N +LK + E ++ S + K+ +TA ++ M
Sbjct: 573 HQKEIKALYTATEK---LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME- 628
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
+ ++ L E + EL + E ++ DY +++L++ +++ ++ +E
Sbjct: 629 ELKVSFSKGLGTET-AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE--MEALR 685
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
A+L I+ ++ + E + ++ + +
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT 745
Query: 824 VISDSEVSQLK---ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
+ D+ SQLK E+LL +LD L++ E E + + L+ ++Q L+ EK
Sbjct: 746 KVIDNFTSQLKATEEKLL----DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 801
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
+ + S++ +++ R+ K ++ N E V ++ +EK +++
Sbjct: 802 AESSKASSITRELQG-----RELKLTNLQENLSE---------VSQVK--ETLEKELQIL 845
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
K E+ ++ + MQ+ + K +K+++F +LE + L +++ +++E DE
Sbjct: 846 K--EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDE 903
Query: 1001 ECETCAEYLKQREEQ-CKRLKEAKIALEIVDKLSNQKVALEKQIE--SLSNTPVSNSTMY 1057
E + ++ E + +K + + K++++ E+ +E L T + + +
Sbjct: 904 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 963
Query: 1058 VATG---SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENE 1104
+ + Q + K++++ KK + ++ +K+ +T N+ E
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1013
Score = 37.9 bits (84), Expect = 0.20
Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 10/148 (6%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY 95
+++ Q +K ++S I + + SL++S + + L + EL ++ + + L G
Sbjct: 1193 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG-- 1250
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
E + L S +++LE + + + ++KNL LK ++++ DT ++
Sbjct: 1251 -----ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQAD-ED 1304
Query: 156 ENVTES--DNLNKEVDDLKKNNECLTQK 181
E ES D LN + DL++ N+ L K
Sbjct: 1305 ERAQESQIDFLNSVIVDLQRKNQDLKMK 1332
>BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 73.7 bits (173), Expect = 3e-12
Identities = 126/634 (19%), Positives = 253/634 (39%), Gaps = 36/634 (5%)
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEV 525
T F L TQ E R DY+ E E L+ + + +A ++E N +
Sbjct: 653 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL--MKVIKEKENSL 710
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+++ +L K + E LN ++ ++ L++ AK E+ + DN ++L
Sbjct: 711 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI---DNFTSQLK 767
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+T L + + K+ ++ + K+ + +LE + + IK E++K
Sbjct: 768 ATEEKLLDLDALRKASSEGKSEMKKLR-QQLEAAEKQIKH--LEIEKN------AESSKA 818
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
+ + L++NL+ Q +E E+ I EK AE + +Q+
Sbjct: 819 SSITRELQGRELKLTNLQENLSEVSQVKETLEK----ELQI-LKEKFAEASEEAVS-VQR 872
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAE 765
+QE +KE + N L++ E L+ + E QL K+ +E IAE
Sbjct: 873 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 932
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-----DSPKR 820
+ + + ++ + T +EN + D + ++
Sbjct: 933 I-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 991
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE-TCAEYLQERDEQCARLKKEK 879
+ + E +L+ +L +++++ + +EL E +E + +E L+K
Sbjct: 992 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1051
Query: 880 LSLEQQVSNLKEQ----IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
L E ++ +E+ ++ + + +QA A A ++ + + ++ A +E
Sbjct: 1052 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1111
Query: 936 NKRL-MKTIEEL-RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQ 993
K+ K EL K+ +LKN V ++ K+ E T ++++ E RKE+E K + Q
Sbjct: 1112 TKQTNAKLQNELDTLKENNLKN-VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1170
Query: 994 RYKELDEECETCAEYL-KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
+ L EE AE L + R+E K + + ++L K K I+ S
Sbjct: 1171 QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1230
Query: 1053 NSTMYVATGSAIVQ-NQQITDVMKENQKLKKMNA 1085
T + + + + ++ + E L+ NA
Sbjct: 1231 LQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1264
Score = 72.5 bits (170), Expect = 8e-12
Identities = 203/1013 (20%), Positives = 409/1013 (40%), Gaps = 111/1013 (10%)
Query: 32 SKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSAL 91
S+ + ET S + + SGT + ++LKE I L + E ++ + S +
Sbjct: 331 SRTGLLTETSSRYAR-KISGTTALQ----EALKEKQQHIEQLLAERDLERAEVAKATSHV 385
Query: 92 EGKYQNLILETQTRD--LLMSQIKSLEMENLTK--DKEIKNLTDSLKTKSKKINELQ--- 144
Q L L D +L + K ++ + + D+E L + L+ + +K+ +LQ
Sbjct: 386 GEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRV 445
Query: 145 -EENDTLSNLIMENVTESDNLNKEVD----DLKKNNECLTQKCIDLEKLVNESENK---- 195
EE+ T +L ++ D N + +K+ + L + +KL E E+
Sbjct: 446 EEESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVAT 505
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS-TRYNKICTLQSELDAGRE 254
+ K+ + + K+ ++ + + N+ D + S + +I +LQ +L+ R
Sbjct: 506 VSEKSRIMELE-KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 564
Query: 255 DCKELCEDFTSIKNHLELHEPNMTMDLD------EKLGENNEFETKAVKVMSEIKRNLNS 308
D + + TS+K H E ++ EKL + NE ++ ++ ++ +
Sbjct: 565 DHQR---EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 621
Query: 309 LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
L + + + ++ K S L GT + + E+ I K ++D +E
Sbjct: 622 LWKSKLETAIASHQQAMEELKVSFSKGL----GTETAEFAELKTQ--IEKMRLDYQHEIE 675
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
Q +E + K + A L + EKEN+ +R + ++ + D +
Sbjct: 676 NLQNQQD--SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 733
Query: 429 K--ENELK----EILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
K E E+K E+L +C + +K+ ID + L A ++ + DAL + S
Sbjct: 734 KLQEAEIKVKELEVLQAKCNEQTKV-ID---NFTSQLKATEEKLLDLDAL--RKASSEGK 787
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
E++K + +LE + T E E+K LT L E
Sbjct: 788 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK-----LTNL-----QE 837
Query: 543 NNANLNLIK-ILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNS 597
N + ++ +K L +E+ LK A+ E+ +S + E NKL + N L +
Sbjct: 838 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 897
Query: 598 LK-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
L+ +L D+ + +E ER Q+IK +K++ DI D
Sbjct: 898 LRENLADMEAKFREKD----EREEQLIKAK----EKLENDIAEIMKMSGDNSSQLTKMND 949
Query: 657 EAKSLLEQNLA-LKEQCEEKTRDCSRLEINIKTHEKTAE-IQNRMIMRLQKQIQEDDKLF 714
E + L E+++ L+ + + + S L+ +I+ AE Q + +++ +E ++
Sbjct: 950 ELR-LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 1008
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV--EGRI--AELESDI 770
+ E K+ N+ + LK Y+ A + ++ E + Q QK L+ E ++ A E+
Sbjct: 1009 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ-NLQKTLLDTEDKLKGAREENSG 1067
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
++ + E + + L+D+ + + + +E+
Sbjct: 1068 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLAS--LEDTKQTNAKL--QNEL 1123
Query: 831 SQLKERLLSCQQELDDLKE-------RYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
LKE L +EL+ KE + +E E ET + ++ +Q + L++E + L
Sbjct: 1124 DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLA 1183
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAV------------NTDEDWANLHSVVVDRMSY-- 929
+++ ++++ + Q +E + + + + DE+ A+L + +
Sbjct: 1184 EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1243
Query: 930 --DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
DAE+EK + + + + L + V ++ K K K E + KE
Sbjct: 1244 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE 1296
Score = 65.7 bits (153), Expect = 9e-10
Identities = 155/769 (20%), Positives = 298/769 (38%), Gaps = 66/769 (8%)
Query: 28 DGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQ 87
+ KSK ++ + S+ I L S T Q+++E + L + E ++K Q
Sbjct: 603 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 662
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD-----KEIKNLTDSLKTKSKKINE 142
+ YQ+ I Q + + EME L KE +N +++++K K +
Sbjct: 663 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 722
Query: 143 --LQEENDTLSNLIMENV---------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVN- 190
L E DTL+ L + + + K +D+ + +K +DL+ L
Sbjct: 723 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 782
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
SE K K + Q + E I+ L I + N S +++ TR EL
Sbjct: 783 SSEGKSEMKKLRQQLEAAEKQIKHLEI-------EKNAESSKASSITR---------ELQ 826
Query: 251 AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
L E+ + + E E + + L EK E +E +AV V ++ +N L
Sbjct: 827 GRELKLTNLQENLSEVSQVKETLEKELQI-LKEKFAEASE---EAVSVQRSMQETVNKLH 882
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
++ + +++ +++ LA ++A+F D E + K + D+ EI++
Sbjct: 883 QK--EEQFNMLSSDLEKLREN-LADMEAKF--REKDEREEQLIKAKEKLENDIAEIMKMS 937
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L + EL+ + L +L + + L+ E + + + KK
Sbjct: 938 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 997
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPA-HKKIT----ILFDALITQYELSRTDYEI 485
E K+ L ++ L K K++ + Q+L A +++ T + ++ + + D E
Sbjct: 998 EEEKKELERKLSDLEK-KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE- 1055
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+K K E + T E+A ++ + +E T+ S D
Sbjct: 1056 DKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1115
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNSLKSL 601
N L E+D LK KN E++ L+ ++ K+ E I LK+
Sbjct: 1116 NAK----LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1171
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ E A EL RS + + +L++ ++ + DE K+
Sbjct: 1172 LSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1230
Query: 662 LEQNLALKEQ-CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
L++++++ EK + +L E+ + E + ++ Q E DK+ +E +
Sbjct: 1231 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV----QTLESDKVKLELK 1286
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
K EL K + + D ++ + Q +Q D + I +L+
Sbjct: 1287 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQ-ESQIDFLNSVIVDLQ 1334
Score = 64.9 bits (151), Expect = 2e-09
Identities = 124/613 (20%), Positives = 267/613 (43%), Gaps = 59/613 (9%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
R++LD K+++ +++E + KLQ++ I K + L+ NE ++ + +L
Sbjct: 714 RSKLD--KAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFTSQLKA 768
Query: 84 IKEQ--------KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
+E+ K++ EGK + L Q + QIK LE+E + + ++T L+
Sbjct: 769 TEEKLLDLDALRKASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAESSKASSITRELQG 827
Query: 136 KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ K+ LQE +S + + L KE+ LK+ +++ + +++ + E+ NK
Sbjct: 828 RELKLTNLQENLSEVSQV-------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 880
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ K + + N++ S L KL +++D ++ + + +L +E
Sbjct: 881 LHQK------EEQFNMLSS-------DLEKLRENLAD--MEAKFREKDEREEQLIKAKEK 925
Query: 256 CKELCEDFTSIK--NHLELHEPNMTMDLDEKLGENNEFE-TKAVKVMSEIKRNLNSLSEQ 312
+ + + N +L + N + L E+ E + + TKA + S +++++ ++ +
Sbjct: 926 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 985
Query: 313 LINNESKKSKDHIDRYK--DSLLAVLDAEFGTTSLDVFEI--LMDNIINKYQIDLDEILE 368
++ + +K H + K + L+ L+ + T+ E+ + ++ + +EIL+
Sbjct: 986 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 1045
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
+Q L + +LK E+ + L +L E + + + + E + + + K
Sbjct: 1046 ---NLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD--KAKAAQTAEDAMQIMEQMTK 1100
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
++ E L +KL+ ++ + +L +++ + L + + E KE
Sbjct: 1101 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME---EFRKE 1157
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS---LHEELTKLYKSKVDENNA 545
L+ A+ + L + +EV S L EE + L ++
Sbjct: 1158 IETLKQAAAQK-SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1216
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
IK EE +L+ +I+ L+EKD +L +L + + L+ EN S KSL+ V+
Sbjct: 1217 ESKFIKDADEEKASLQKSISITS---ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV 1273
Query: 606 -TREKETQASELE 617
T E + EL+
Sbjct: 1274 QTLESDKVKLELK 1286
Score = 46.8 bits (106), Expect = 4e-04
Identities = 103/587 (17%), Positives = 243/587 (41%), Gaps = 47/587 (8%)
Query: 533 TKLYKSKVDENNANLNLIKI----LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTI 588
TKL +++ E +L K L E++ ++A + +++ L EKD L V +
Sbjct: 470 TKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMEL-EKDLALR--VQEV 526
Query: 589 NGLKEENNSLKSLNDV-ITREKETQASELERSCQVIK-QNGFELDKMKADILMXXXXXXX 646
L+ S K DV ++ + S L+ +V + + E+ +K
Sbjct: 527 AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK 586
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
++ L ++N +LK + E ++ S + K+ +TA ++ M + +
Sbjct: 587 EIKALYTATEK---LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME-ELK 642
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL 766
+ L E + EL + E ++ DY +++L++ +++ ++ +E A+L
Sbjct: 643 VSFSKGLGTET-AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE--MEALRAKL 699
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
I+ ++ + E + ++ + + +
Sbjct: 700 MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI 759
Query: 827 DSEVSQLK---ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
D+ SQLK E+LL +LD L++ E E + + L+ ++Q L+ EK +
Sbjct: 760 DNFTSQLKATEEKLL----DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 815
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ S++ +++ R+ K ++ N E V ++ +EK +++K
Sbjct: 816 SKASSITRELQG-----RELKLTNLQENLSE---------VSQVK--ETLEKELQILK-- 857
Query: 944 EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECE 1003
E+ ++ + MQ+ + K +K+++F +LE + L +++ +++E DE E
Sbjct: 858 EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 917
Query: 1004 TCAEYLKQREEQ-CKRLKEAKIALEIVDKLSNQKVALEKQIE--SLSNTPVSNSTMYVAT 1060
+ ++ E + +K + + K++++ E+ +E L T + + ++
Sbjct: 918 QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQK 977
Query: 1061 G---SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENE 1104
+ Q + K++++ KK + ++ +K+ +T N+ E
Sbjct: 978 SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1024
Score = 37.9 bits (84), Expect = 0.20
Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 10/148 (6%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY 95
+++ Q +K ++S I + + SL++S + + L + EL ++ + + L G
Sbjct: 1204 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG-- 1261
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
E + L S +++LE + + + ++KNL LK ++++ DT ++
Sbjct: 1262 -----ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQAD-ED 1315
Query: 156 ENVTES--DNLNKEVDDLKKNNECLTQK 181
E ES D LN + DL++ N+ L K
Sbjct: 1316 ERAQESQIDFLNSVIVDLQRKNQDLKMK 1343
Score = 36.7 bits (81), Expect = 0.46
Identities = 49/265 (18%), Positives = 111/265 (41%), Gaps = 22/265 (8%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL-QERDEQCARLKKEKLSLEQQV 886
S V ++++ L + D + D+ T E +E+ E +L++EK +E
Sbjct: 383 SHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQ 442
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK--RLMKTIE 944
++E+ T+ +E++++ ++ NT L + + EK K +L + +E
Sbjct: 443 FRVEEESITKGDLEQKSQISEDPENTQ---TKLEHARIKELEQSLLFEKTKADKLQRELE 499
Query: 945 ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE-------------LEDCKAELEEL 991
+ R K+ + +++K + ++ E + + L++ + E+L
Sbjct: 500 DTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKL 559
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPV 1051
+ + E + E+ REE KE K +KLS + +L+ ++E +
Sbjct: 560 EVTRTDHQREITSLKEHFGAREE--THQKEIKALYTATEKLSKENESLKSKLEHANKENS 617
Query: 1052 SNSTMYVA-TGSAIVQNQQITDVMK 1075
++ + +AI +QQ + +K
Sbjct: 618 DVIALWKSKLETAIASHQQAMEELK 642
>D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 protein.
Length = 3225
Score = 73.3 bits (172), Expect = 4e-12
Identities = 207/1086 (19%), Positives = 436/1086 (40%), Gaps = 119/1086 (10%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE 86
L+ K KN +T N S T ++ + L+E ++NL +++ EL + +
Sbjct: 1818 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGEL-KMLQEEVTKMNLLNQQIQEELSRVTK 1876
Query: 87 QKSALEGKYQNLILETQTRDLLMSQIKSLE------MENLTKDKEIKN--LTDSLKTKSK 138
K E + +L + LM+Q+ L +++T D +IKN L +K K
Sbjct: 1877 LKETAEEEKDDL------EERLMNQLAELNGSIGNYCQDVT-DAQIKNELLESEMKNLKK 1929
Query: 139 KINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
++EL+EE L+ E + KE L+K ++ E NK
Sbjct: 1930 CVSELEEEKQ---QLVKEKTKVESEIRKEY--LEK-----------IQGAQKEPGNKSHA 1973
Query: 199 KNICAQCKLKENLIQSLH---IGYDNTLSKLNRSISDSN-TSTRYNKICTLQSE-LDAGR 253
K + K K+ ++ L I Y +S L R++ T K + E L
Sbjct: 1974 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2033
Query: 254 EDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
E K+ + S K L+ + L + L E ++ V S++K+ L +L
Sbjct: 2034 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2093
Query: 314 INNESK--KSKDHIDRYKDSLLAV-LDAEFGTTSLDVFEILMDNIINKYQIDLDEI---L 367
E K K K ++ D+L + E + V D + + Q +LD L
Sbjct: 2094 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2153
Query: 368 EKYTK----VQGDLNECTSELKSVNEKLA----SLNSQLIEKENACNILRIQKER--IHE 417
+TK +Q D + E K K + S ++ KE+ C++L+ Q + IH
Sbjct: 2154 AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM 2213
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI-LFDALITQY 476
+ I ++ + ++ E + ++L + D + +++L + + T L+ + +Q
Sbjct: 2214 EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHS--SQN 2271
Query: 477 ELSRTDYEIEK------------EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE---EA 521
EL++ + E++ EK + + G + + ++ LE +A
Sbjct: 2272 ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQA 2331
Query: 522 HNEVKS-LHEELTKLYKSKVDENNANLNLIKIL--------SEEIDALKIAIAKNEEKML 572
E+ S LHEE+ + + + I++ +EI L+ +++ EE+ +
Sbjct: 2332 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2391
Query: 573 SLSEKD----NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELER---SCQVIKQ 625
L E++ +K +L+ T+ +K+EN K+ D + + ++ +R Q +++
Sbjct: 2392 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2451
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXX-DEAKSLLEQNLALKEQCEEKTRDCSR-LE 683
+ K ++ L +N L + + D ++ +
Sbjct: 2452 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2511
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
I ++ E+Q + L+ + + ++ E E +L + AL+ + K++E
Sbjct: 2512 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2571
Query: 744 SSREAVNQLTTQKDLV--EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
S + +++QLT Q + EG + + ++ ++
Sbjct: 2572 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCV 2631
Query: 802 GDE-NRDLGE-NPKL---------DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
E + +GE KL D R+ + ++ V++L L+ +Q+L + +
Sbjct: 2632 QKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKE 2691
Query: 851 YKELDDECETCAEYL----QERD---EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
K L + ++ + RD E+ LK++ + ++++ LKEQ + ER A
Sbjct: 2692 NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNR--ERDA 2749
Query: 904 KFADVA--VNTDED--WANLHSVVVDRMSYDAE-VEKNKRLMKTIEELR-YKK--QDLKN 955
++ A +N+ E+ ++L + +S D + + + +L + +++ + K L+N
Sbjct: 2750 LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2809
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
+ +EK+ K ++ + + AE++ LK+ L + + + LK ++Q
Sbjct: 2810 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ 2869
Query: 1016 CKRLKE 1021
++ +
Sbjct: 2870 YLQINQ 2875
Score = 71.7 bits (168), Expect = 1e-11
Identities = 188/1023 (18%), Positives = 412/1023 (40%), Gaps = 80/1023 (7%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE-------ENDTLSNLIMENVTE 160
+ +Q+K +E E + + ++ + T L KS+++ +LQE E ++L + E
Sbjct: 1273 IKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH 1332
Query: 161 SDNLNKEVDDLK------KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKE---NL 211
+++L ++++ + ++ L K +L+KL+++ E + + Q KE
Sbjct: 1333 AESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDV--SYLSGQLSEKEAALTK 1390
Query: 212 IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE 271
IQ+ I ++ + L+ + + +I LQ EL ++ +E+ E+ + K ++
Sbjct: 1391 IQTEIIEQEDLIKALHTQL-EMQAKEHDERIKQLQVELCEMKQKPEEIGEE-SRAKQQIQ 1448
Query: 272 LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS--EQLINNESKKSKDHIDRYK 329
+ E L EN + + I+R SL+ E ++ ++K+ + R
Sbjct: 1449 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGR-- 1506
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDN-IINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
LA+L E ++ L++N ++ L LE T+ D + E++S+
Sbjct: 1507 ---LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLK 1560
Query: 389 EKLASLNSQLIEK----ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
+ +++ EK + IL E + + + +V+ + K+ L +
Sbjct: 1561 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ-HVVEAVRQEKQELYGKLRST 1619
Query: 445 SKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXX 504
K + + L + +++ + + E E ++LR E A
Sbjct: 1620 EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1679
Query: 505 XXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAI 564
+++E VK +E L+K ++S + E ++ LSEE+ LK I
Sbjct: 1680 METLLSSNA---SMKEELERVKMEYETLSKKFQSLMSEKDS-------LSEEVQDLKHQI 1729
Query: 565 AKNEEKMLSL--SEKDNKLT----ELVSTINGLKEENNSLKSLNDVITREKETQASELER 618
N K +L +EK + T E +I G EE +SL E A
Sbjct: 1730 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1789
Query: 619 SCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD 678
+ + E++ I + +++L + L Q K +
Sbjct: 1790 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1849
Query: 679 CSRLEINI-KTHEKTAEIQNRM--IMRLQKQIQED-DKLFIEKETKLNELTNKYEALKRD 734
L+ + K + +IQ + + +L++ +E+ D L +L EL +D
Sbjct: 1850 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1909
Query: 735 Y-DAAVKD--LESS----REAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
DA +K+ LES ++ V++L +K + ++ES+IR E +
Sbjct: 1910 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN 1969
Query: 788 XXXXXXXXXXXXTFGDENRDLGEN----PKLDDSPKRSISVISDSEVSQLKERLLSCQQE 843
E + L ++ + + +R++ + + K+ L ++
Sbjct: 1970 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKD-LEITKEN 2028
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
L E K+ E + L + + AR+ + L L++++ + KE +++Q +
Sbjct: 2029 LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM----KQ 2084
Query: 904 KFADVAVNTDE-DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQK 962
K D+ ++ + +L + DA + L +TI E++ V ++Q+
Sbjct: 2085 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2144
Query: 963 AMEKYTKKDKEFEAKRKELEDCKAE-LEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
++ + F L+D + ++E K+ ++ + ++ E ++ +E+ C LK+
Sbjct: 2145 NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2204
Query: 1022 --AKIALEIVD-KLSNQKVALEKQI-ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKEN 1077
++++ + + K++ ++ +KQI ES + T V T +N+++ ++E
Sbjct: 2205 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG--ENKELLSQLEET 2262
Query: 1078 QKL 1080
+ L
Sbjct: 2263 RHL 2265
Score = 70.5 bits (165), Expect = 3e-11
Identities = 187/1018 (18%), Positives = 403/1018 (39%), Gaps = 103/1018 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E ++ ++L ++ + +I E+ A + + L +R + + KSL+ E
Sbjct: 1418 ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1477
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
I+ LT SL +++ +E DT+ + E D L E+D N+ L+ C
Sbjct: 1478 TIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1537
Query: 185 LEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICT 244
L KL E + KE L++ + S + I++S +K
Sbjct: 1538 L-KLALEGLTED-----------KEKLVKEIE-------SLKSSKIAESTEWQEKHK--E 1576
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKR 304
LQ E + + + + + I++ +E +L KL + + K + E ++
Sbjct: 1577 LQKEYEILLQSYENVSNEAERIQHVVEAVRQE-KQELYGKLRSTEANKKETEKQLQEAEQ 1635
Query: 305 NLNSLSEQLIN-NESKKSKD-HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+ + E++ +SK+ K ++ D L A + G T+ + E L+ + + + +
Sbjct: 1636 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA-GDTAKECMETLLSSNASMKE-E 1693
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L+ + +Y + SE S++E++ L Q+ + N ++ H+ + V
Sbjct: 1694 LERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI--EGNVSKQANLEATEKHDNQTNV 1751
Query: 423 T---IDIVKKENELKEILTKECLKLSKLKIDIPRD----LDQDLPAHKKITILFDALITQ 475
T + E E ++ L+ + + + +D +H +I I Q
Sbjct: 1752 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQ-IDQ 1810
Query: 476 YELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK- 534
+ E EK+K + + T + + E+K L EE+TK
Sbjct: 1811 LKERIAGLEEEKQKNKEFSQTLE----------NEKNTLLSQISTKDGELKMLQEEVTKM 1860
Query: 535 -LYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLK 592
L ++ E + + +K EE D L EE+++ N+L EL +I
Sbjct: 1861 NLLNQQIQEELSRVTKLKETAEEEKDDL-------EERLM------NQLAELNGSIGNYC 1907
Query: 593 EENNSLKSLNDVITREKETQ---ASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
++ + N+++ E + SELE Q + + E K++++I
Sbjct: 1908 QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK---EKTKVESEIRKEYLEKIQGAQ 1964
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ- 708
AK L E +++ ++ +DC R + I E+T + + QK ++
Sbjct: 1965 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2024
Query: 709 --EDDKLFIEKETKLNELTNKYEALKRDYDAAV-----------KDLESSREAVNQLTTQ 755
E+ +E K ++ L D + K+L+S++E+V Q
Sbjct: 2025 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2084
Query: 756 KDL-VEGRIAEL-ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
KD +E R+ + E ++ ++ T +++++ + +
Sbjct: 2085 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2144
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
DS ++ + S S +R + +D+ K+ ++ D ++ E ++ +++ C+
Sbjct: 2145 NLDSTVTQLAAFTKSMSSLQDDR----DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2200
Query: 874 RLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK + + + LK I R + + A V + + ++ + ++
Sbjct: 2201 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD--TLQGENKELLSQ 2258
Query: 933 VEKNKRL----MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E+ + L + +L + + LK+ +T + ++EK ++ E ++ E A++
Sbjct: 2259 LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE---ADI 2315
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ K Y++L+ + + E + E+ +KE K I+ LS ++ A++ I L
Sbjct: 2316 QNSKFSYEQLETDLQASRELTSRLHEEI-NMKEQK----IISLLSGKEEAIQVAIAEL 2368
Score = 70.1 bits (164), Expect = 4e-11
Identities = 188/1002 (18%), Positives = 398/1002 (39%), Gaps = 69/1002 (6%)
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINEL 143
+KE++ ++ ++ I + L +K+LE K+++ ++L + +
Sbjct: 1980 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2039
Query: 144 QEENDTLSNLIMENVTES-----DNLN--KEVDDLKKNNEC-LTQKCIDLEKLVNESENK 195
Q E + L+ + +E+ DNL KE+ K++ + + QK DLE+ + ++E K
Sbjct: 2040 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2099
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS--DSNTSTRYNKICTLQSELDAGR 253
+ Q KL + +H+ + T+ ++ +++ D + + ++L A
Sbjct: 2100 HLKEKKNMQEKLDALRREKVHL--EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2157
Query: 254 EDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
+ L +D + + + E + + K E + V+ + R ++ E+L
Sbjct: 2158 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSK-EEEIRLKEDNCSVLKDQLRQMSIHMEEL 2216
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV 373
N S+ +H + +S A + + D + ++++ L+E Y
Sbjct: 2217 KINISRL--EHDKQIWESK-AQTEVQLQQKVCDTLQGENKELLSQ----LEETRHLYHSS 2269
Query: 374 QGDLNECTSELKSVNEKLASLNSQLIE-KENACNILRIQKERIHEISSAVTIDIVKKENE 432
Q +L + SELKS+ ++L L++ L + KE N+ I +++ +I ++ + E +
Sbjct: 2270 QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS-KFSYEQLETD 2328
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKK--ITILFDALITQY-----ELSRTDYEI 485
L+ ++E +I++ L + K+ I + L Q+ EL +
Sbjct: 2329 LQA--SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2386
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
E+E + LE KAV T+++ + + K+ + K S ++ +
Sbjct: 2387 EEENIVLEEENKKAVDKTNQLMET-----LKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2441
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE----LVSTINGLKEENNSL--- 598
+ + L E L I + K ++ + + ++NKL E L S ++ L EN L
Sbjct: 2442 IVGDYQQLEER--HLSIILEK-DQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2498
Query: 599 -----KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ LN VIT + Q LE Q K+ + K++ +
Sbjct: 2499 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2558
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+E + L ++ +LK + TR + L E + + +++ + RL
Sbjct: 2559 LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQ 2618
Query: 712 KLFIEKETKLNELTNKYEALKRD---YDAAVKDLESSREAVNQLTTQKDLVEGRIAELES 768
K E E +L + + EA K+ D K+L+ + + + E R+AEL
Sbjct: 2619 KRIAELEEEL--VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELAR 2676
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
D+ E + + +RD N +LD+ KR S
Sbjct: 2677 DL-VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA-NEELDEL-KRKYDA-SLK 2732
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
E++QLKE+ L ++ L E ++ E +L++ ++Q ++ L L Q+ +
Sbjct: 2733 ELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2792
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
Q+++ A + D W L + ++ L+
Sbjct: 2793 SYNQVQSFSKA-----MASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2847
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
L+N ++ K ++ ++ + + EL KA+L+E + + K E +
Sbjct: 2848 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2907
Query: 1009 LKQREEQCKRLKEAKIALEIVDKLSNQK--VALEKQIESLSN 1048
+ + +L+ K + EI ++ ++ +A+ + + LS+
Sbjct: 2908 NLSWQHELDQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH 2949
Score = 68.9 bits (161), Expect = 9e-11
Identities = 209/1068 (19%), Positives = 423/1068 (39%), Gaps = 110/1068 (10%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN 119
C+SLK + + EKL E+ +K K A ++Q E Q ++ Q EN
Sbjct: 1535 CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ----SYEN 1590
Query: 120 LTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV-DDLKKNNEC 177
++ + E I+++ ++++ + +++ + + + E++ +E+ + ++K +
Sbjct: 1591 VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1650
Query: 178 LTQKCIDLEKLVNESENKIGP----KNICAQCKLKENL-----IQSLHIGYDNTLSKLNR 228
QK ++LE+ + ++ P C + L N ++ + + Y+ K
Sbjct: 1651 KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS 1710
Query: 229 SISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE----------LHEPNMT 278
+S+ ++ + + Q E + ++ E E + N E + +++
Sbjct: 1711 LMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLS 1770
Query: 279 MDLDEKLGEN-------NEFETKAVKVMSEIKRNLNSL---SEQLINNESKKSKDH---- 324
M E+ N +K EI L + E++ E +K K+
Sbjct: 1771 MSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQ 1830
Query: 325 -IDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE 383
++ K++LL+ + + G + E+ N++N+ + E L + TK++ E +
Sbjct: 1831 TLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ---QIQEELSRVTKLKETAEEEKDD 1887
Query: 384 LKS-VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
L+ + +LA LN + +I+ E + + + + E E K+ L KE
Sbjct: 1888 LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE-KQQLVKEKT 1946
Query: 443 KL-SKLKIDIPRDLD--QDLPAHKKITILFDALI--TQYELSRTDYEI--EKEKLRLETG 495
K+ S+++ + + Q P +K L+ Q E+ + + +EK+
Sbjct: 1947 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2006
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
T KA+ + L +A K EL +K +D+ + ++L++
Sbjct: 2007 TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS-FKVLLDDTQS--EAARVLAD 2063
Query: 556 EIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTI--NGLKEENNSLKSLNDVITREK--- 609
+ LK + N+E + S + +KD L + LKE+ N + L D + REK
Sbjct: 2064 NL-KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL-DALRREKVHL 2121
Query: 610 ETQASE----LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS----- 660
E E L + + ++Q LD + DEAK
Sbjct: 2122 EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF 2181
Query: 661 ------------LLEQNLA-LKEQCEEKTRDCSRLEINIKTHEKTAEI-QNRMIMRLQKQ 706
L E N + LK+Q + + L+INI E +I +++ +Q Q
Sbjct: 2182 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ 2241
Query: 707 IQEDDKLFIEKE---TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRI 763
+ D L E + ++L E + Y + + + +L+S ++ + L+ + + +
Sbjct: 2242 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2301
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-DSPKRSI 822
LE IR +Q A + + E ++ E + S K
Sbjct: 2302 GNLEGIIR-QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEA 2360
Query: 823 SVISDSEVSQLKER-LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
++ +E+ Q ++ + + L +E L++E + + + E +KKE +
Sbjct: 2361 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENI- 2419
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV---DRMSYDAEVEKNKR 938
QQ + L +++ ++ D V + H ++ D++ +A E NK
Sbjct: 2420 --QQKAQLDSFVKSMSSLQND---RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK- 2473
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L + I LR DL + K+ + +Y ++D K+ + K LE Q+ KEL
Sbjct: 2474 LKEEIRGLRSHMDDLNSENAKLDAELIQY-REDLNQVITIKDSQQ-KQLLEVQLQQNKEL 2531
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+ + E LK+ EE + L+ + AL+ +K L K+IESL
Sbjct: 2532 ENKYAKLEEKLKESEEANEDLRRSFNALQ------EEKQDLSKEIESL 2573
Score = 66.5 bits (155), Expect = 5e-10
Identities = 184/1017 (18%), Positives = 397/1017 (39%), Gaps = 78/1017 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ-TRDLLMSQIKSLEMEN 119
++LKE N ++ E ++ + E S L+ Y + Q +++ L + L+ EN
Sbjct: 895 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 954
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE--- 176
+ ++++ + K ++++ L+EE L + + + S+ EV++ K+N E
Sbjct: 955 EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1014
Query: 177 -CLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK---ENLIQSLHIGYDNTLSKLNRSI 230
C+T KC ++E + + SE ++ ++I + K E Q+L + TL I
Sbjct: 1015 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQI 1074
Query: 231 SDSNTSTRYNKIC---TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKL-- 285
N+ + S DA D L ++ I + +L+EK+
Sbjct: 1075 DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA 1134
Query: 286 --GENNEFETKAVKVMSEIKRNLNSL--SEQLINNESKKSKDHIDRYKDSLLAVLDAEFG 341
E + + K + ++ K L E+ + E K+ KD +R L +F
Sbjct: 1135 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNR--------LQEQFD 1186
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASL----NSQ 397
S + I + + + QI + E ++ D E S + E L ++Q
Sbjct: 1187 EQSKENENI--GDQLRQLQIQVRESIDGKLP-STDQQESCSSTPGLEEPLFKATEQHHTQ 1243
Query: 398 LIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC---LKLSKLKIDIPRD 454
+ + N C E + ++ +K +LKEI ++ LK+S ++ +
Sbjct: 1244 PVLESNLCPDWPSHSEDASALQGGTSVAQIKA--QLKEIEAEKVELELKVSSTTSELTKK 1301
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
++ ++I I + + E+ E L+ + +++
Sbjct: 1302 SEEVFQLQEQIN-KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ--- 1357
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L+E + E+++ L ++ E A L KI +E I+ + A + + +
Sbjct: 1358 -PKLDELQKLISKKEEDVSYL-SGQLSEKEAALT--KIQTEIIEQEDLIKALHTQLEMQA 1413
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITR-EKETQASELERSCQVIKQNGF---EL 630
E D ++ +L + +K++ + + + +++ QA+ + R + +K+N EL
Sbjct: 1414 KEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK-EALKENKSLQEEL 1472
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+ I E ++L + L+E+ ++ + R + ++
Sbjct: 1473 SLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLS 1532
Query: 691 KTAEIQNRMIMRL----QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
+ E + L +K ++E + L K + E K++ L+++Y+ ++ E+
Sbjct: 1533 SSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVS 1592
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG-DEN 805
++ + V EL +R+ + F +
Sbjct: 1593 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ 1652
Query: 806 RDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
+ + E + +D + + D+ + E LLS + + ER K E ET ++
Sbjct: 1653 QKILELEEENDRLRAEVHPAGDT-AKECMETLLSSNASMKEELERVKM---EYETLSKKF 1708
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD 925
Q L EK SL ++V +LK QI + V +QA A ++ N+
Sbjct: 1709 QS-------LMSEKDSLSEEVQDLKHQI--EGNVSKQANLE--ATEKHDNQTNVTEEGTQ 1757
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
+ + E E++ M T K+ + K + + + + + +L++
Sbjct: 1758 SIPGETE-EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ-QIDQLKERI 1815
Query: 986 AELEELKQRYKE----LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
A LEE KQ+ KE L+ E T + ++ + K L+E + ++++ ++++
Sbjct: 1816 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1872
Score = 59.7 bits (138), Expect = 6e-08
Identities = 191/1006 (18%), Positives = 386/1006 (38%), Gaps = 90/1006 (8%)
Query: 91 LEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL 150
LE ++L+ Q DLL ++ + E N ++++ + T + +EE+ L
Sbjct: 227 LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKIL 286
Query: 151 SNLIMENVTES----DNLNKEVDDLKKNNECLTQKCIDLEKLVN--ESENKIGPKNICAQ 204
+ V E NL +E+ L + E Q +LE + E ++K + +
Sbjct: 287 LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 346
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
+ Q L D + ++ + D N T+Q D ++ KE+ +
Sbjct: 347 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQA-VQSAQTIQQLEDQLQQKSKEISQFLN 405
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNE--FETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
+ L+ HE + E + E + + N L+++ +
Sbjct: 406 RLP--LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 463
Query: 323 DHIDRYKDSLLAVLDAE--FGTTSLDVFEILMDNIINKYQIDLDE----ILEK-YTKVQG 375
+ S + +L+A+ G +V EI + +I NK +E +LE +++
Sbjct: 464 KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK 523
Query: 376 DLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE 435
+L+ E+K E++A L QL K +E HE+ + ++ E +
Sbjct: 524 ELSVLLLEMKEAQEEIAFLKLQLQGKR--------AEEADHEVLDQKEMKQMEGEG-IAP 574
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG 495
I K L+ + + + + LPA +K + T+++ SRT EI +E
Sbjct: 575 IKMKVFLEDTGQDFPLMPNEESSLPAVEK-----EQASTEHQ-SRTSEEISLNDAGVELK 628
Query: 496 TAKAVXXXXXXXXXXXXXXF-DTLEEAHNEVKSLH---EELTKLYKSKVDENN---ANLN 548
+ K D LE +++ L + ++Y+ +DE +NLN
Sbjct: 629 STKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN 688
Query: 549 -LIKILSEEID---ALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL-----------KE 593
LI+ + D + A+++ +++LS ++ + +TEL + + L +
Sbjct: 689 QLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRL 748
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ S + ++++T + + + E + I+ ELD ++
Sbjct: 749 DYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQN 808
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK- 712
E E+ + + EE ++ S+ E+ I ++ + R + LQ+ I+E D+
Sbjct: 809 KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 868
Query: 713 ------LFIEKETKLNE-----------LTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
EK +LNE L + L R +A + +E E + L
Sbjct: 869 VTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQN 928
Query: 756 KDLVE--GRIA--ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
D + G+I+ EL+ + + +E +L +
Sbjct: 929 YDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 988
Query: 812 PK--LDDSPKRSISVISDSEVSQLKERLLS--CQQELDDLKERYKELDDECETCAEYLQE 867
K + S V D E + E+ ++ CQ+ LK+ E + E + + L+E
Sbjct: 989 SKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1048
Query: 868 R---DEQCARLKKEKLSLEQ----QVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLH 920
+ +EQ L K+ Q Q+ L+ +I Q + ++ ++ + + A +
Sbjct: 1049 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1108
Query: 921 SVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-R 978
VV E K L + I L +K+ L+ + + + + KK +E E R
Sbjct: 1109 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1168
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
+EL+ K + L++++ E +E E + L+Q + Q + + K+
Sbjct: 1169 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL 1214
Score = 57.6 bits (133), Expect = 2e-07
Identities = 217/1101 (19%), Positives = 432/1101 (39%), Gaps = 103/1101 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQ-IKSLEMENLT 121
++E ++ I L L+K EL + AL+ + L+ + + + +Q I+ LE +
Sbjct: 340 MEEKTSHI-LSLQKTGQEL---QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQ 395
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESD--NLNKEVDDLKKNNECLT 179
K KEI + L + + Q + N + VTE + +L K V +L+ L
Sbjct: 396 KSKEISQFLNRLPLQQHETAS-QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALL 454
Query: 180 QKCIDLEKLVNESENKIGPKNIC-AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
I+LE+L E+E + AQ + E + I + +K + S +S
Sbjct: 455 LSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL 514
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLE---LHEPNMTMDLDEKLGENNEFETKA 295
N EL + KE E+ +K L+ E + + LD+K + E E A
Sbjct: 515 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV-LDQKEMKQMEGEGIA 573
Query: 296 VKVMSEIKRNLNSLSEQLINNES--------KKSKDHIDRYKDSL-LAVLDAEFGTTSLD 346
M + + N ES + S +H R + + L E +T D
Sbjct: 574 PIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQD 633
Query: 347 VFEIL--MDNIINKYQIDLDEILEKYTKVQGDLNECTSEL-KSVNEKLASLNS--QLIE- 400
+ L + +I +Q +L+ + + +++ + ++ K+++EK +++ QLIE
Sbjct: 634 GDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE 693
Query: 401 -KENACN----ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
K+NA N + +ER +S + +V EL+ + + + L++ + D
Sbjct: 694 FKKNADNNSSAFTALSEERDQLLSQVKELSMV---TELRAQVKQLEMNLAEAERQRRLDY 750
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR-LETGTAKAVXXXXXXXXXXXXXX 514
+ +T +L + + E+ + +L ++ ++
Sbjct: 751 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 810
Query: 515 FDTLEEAHN--EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ LE A + S EEL++ K E L+ +++ L+ I + ++++
Sbjct: 811 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 870
Query: 573 SLS-EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV---IKQNGF 628
+S K+ +L L E +LK ++++R +E + ++E +V +KQN
Sbjct: 871 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 930
Query: 629 EL--------DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCS 680
E+ ++++ + + K LL++ L+E+ +D S
Sbjct: 931 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN-LKDES 989
Query: 681 RLEINIKTHEK--------TAEIQNRMIMRLQKQIQEDDKLFI-EKETKLNELTNKYE-- 729
+ EI + E+ E + + ++I+ K I EKE +L + E
Sbjct: 990 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1049
Query: 730 -ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
A + + A VK + + + T Q DL++ I+E ++ I+ T+
Sbjct: 1050 LAAEEQFQALVKQMN---QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1106
Query: 789 XXXXXXXXXXXTFGDEN-------RDLGENPKLDDSPKRSISVISDSEV----SQLKERL 837
T E+ + L + + K+ ++ + +Q KER
Sbjct: 1107 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1166
Query: 838 L--SCQQELDD---LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
L +Q+ DD L+E++ E E E + L++ Q KL Q +
Sbjct: 1167 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1226
Query: 893 IRTQQPV----ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
++P+ E+ + N DW + HS + V + K +K IE
Sbjct: 1227 PGLEEPLFKATEQHHTQPVLESNLCPDWPS-HSEDASALQGGTSVAQIKAQLKEIEA--- 1282
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
+K +L+ K+ + TKK +E ++++ E+E LK E + E+ +
Sbjct: 1283 EKVELE---LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1339
Query: 1009 LKQREEQ---CKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
L+ + Q + L+E + L+ + KL ++K E+ + LS + I+
Sbjct: 1340 LESSQLQIAGLEHLRELQPKLDELQKLISKK---EEDVSYLSGQLSEKEAALTKIQTEII 1396
Query: 1066 QNQQITDVMKENQKLKKMNAK 1086
+ + D++K +M AK
Sbjct: 1397 EQE---DLIKALHTQLEMQAK 1414
Score = 55.6 bits (128), Expect = 9e-07
Identities = 179/1029 (17%), Positives = 419/1029 (40%), Gaps = 88/1029 (8%)
Query: 103 QTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESD 162
Q D L +I LE E K+KE ++ K+ ++++ ++ L ++ E VT+ +
Sbjct: 1806 QQIDQLKERIAGLEEEK-QKNKEFSQTLEN--EKNTLLSQISTKDGELK-MLQEEVTKMN 1861
Query: 163 NLNKEVDD----LKKNNECLTQKCIDLE-KLVNESENKIGP-KNIC---AQCKLKENLIQ 213
LN+++ + + K E ++ DLE +L+N+ G N C ++K L++
Sbjct: 1862 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE 1921
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
S +S+L + + ++SE+ R++ E + + + H
Sbjct: 1922 SEMKNLKKCVSEL-----EEEKQQLVKEKTKVESEI---RKEYLEKIQGAQKEPGN-KSH 1972
Query: 274 EPNMTMDLDEKLGENNEFETKAVKV---MSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ L EK E + + ++ +S ++R + +L + + ES+K ++ K+
Sbjct: 1973 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQKD---LEITKE 2027
Query: 331 SLL-AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+L AV + L F++L+D+ ++ L + L+ ++Q + S++K +E
Sbjct: 2028 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2087
Query: 390 KLASLNSQ-----LIEKENA---CNILRIQKERIHEISSAVTIDIVKKENELKEI----- 436
L Q L EK+N + LR +K + E + + + KK+ E++++
Sbjct: 2088 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2147
Query: 437 -----LTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR 491
L +S L+ D R +D+ +K + + + L + + K++LR
Sbjct: 2148 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR 2207
Query: 492 LETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK 551
+ +++ +A EV+ L +++ + EN L+ ++
Sbjct: 2208 -QMSIHMEELKINISRLEHDKQIWES--KAQTEVQ-LQQKVCDTLQG---ENKELLSQLE 2260
Query: 552 ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKET 611
+ + +AK E ++ SL ++ LT+L +++ KE+ +L+ + + +E +
Sbjct: 2261 ETRHLYHSSQNELAKLESELKSLKDQ---LTDLSNSLEKCKEQKGNLEGI--IRQQEADI 2315
Query: 612 QASELE-RSCQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK 669
Q S+ + Q EL ++ +I M A + L Q +
Sbjct: 2316 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2375
Query: 670 -EQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY 728
++ E I ++ K A + +M K I++++ I+++ +L+
Sbjct: 2376 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN---IQQKAQLDSFVKSM 2432
Query: 729 EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXX 788
+L+ D D V D + E + +KD + A + ++ E
Sbjct: 2433 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE------IRGLRSHMD 2486
Query: 789 XXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS-------DSEVSQLKERLLSCQ 841
DL + + DS ++ + + +++ ++L+E+L +
Sbjct: 2487 DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2546
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVER 901
+ +DL+ + L +E + ++ ++ ++L ++ +L+++ + + + E
Sbjct: 2547 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2606
Query: 902 QAKFADVAVNTDEDWANLHS--VVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ + + ++ + A L V V + + E +L K ++ L + ++N
Sbjct: 2607 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2666
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++ + + + E E K + L Q + + ++ + ++ KR
Sbjct: 2667 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2726
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQ 1078
+A +L+ + +L Q + ++ LS T S NST + NQQ+ + +++
Sbjct: 2727 YDA--SLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL---LSKDE 2781
Query: 1079 KLKKMNAKL 1087
+L ++++L
Sbjct: 2782 QLLHLSSQL 2790
Score = 38.3 bits (85), Expect = 0.15
Identities = 52/231 (22%), Positives = 111/231 (48%), Gaps = 24/231 (10%)
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQER----DEQCARLK---KEKL-SLEQ 884
++ERL +Q + +LK+ ++ D + + E LQE D + +LK K KL SL +
Sbjct: 11 VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK 70
Query: 885 QVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
+ +K Q T P E Q ++ ++ + + + ++++ + ++++ + L+ T++
Sbjct: 71 YIEEMKAQGGTVLPTEPQ---SEEQLSKHDKSSTEEEMEIEKIKH--KLQEKEELISTLQ 125
Query: 945 E--LRYKKQDLKNTVTKMQK-AMEKYTKKDKE--FEAKRKELEDCKAE----LEELKQRY 995
+ + + + T+M++ M K ++KE + +L +AE L ++Q
Sbjct: 126 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQLSSMQQVV 185
Query: 996 KELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+E D ET + +E + + +A + E+ KL + LE+ ESL
Sbjct: 186 REKDARFET--QVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESL 234
Score = 38.3 bits (85), Expect = 0.15
Identities = 96/539 (17%), Positives = 215/539 (39%), Gaps = 55/539 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANL----NLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
+V++ ++ ++ + K++E+ +L ++ +L +E+ A A +N+ L + +
Sbjct: 211 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTA---AEQRNQILSQQLQQMEA 267
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILM 639
+ L +T+ +EE+ L ++ E++ L+ + + + + +A++
Sbjct: 268 EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL-- 325
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
E + L+L++ +E C L+ + K + +N
Sbjct: 326 ----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK---DQNSKLLQDKNEQ 378
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL- 758
++ + IQ+ + +K ++++ N+ L++ A+ Q T++++
Sbjct: 379 AVQSAQTIQQLEDQLQQKSKEISQFLNRLP-LQQHETASQTSFPDVYNEGTQAVTEENIA 437
Query: 759 -VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT--FGDENRDLGENPKLD 815
++ R+ ELE++ +++ G+ +R++ E +D
Sbjct: 438 SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVD 497
Query: 816 DSPKRSIS-------VISDS------EVSQLKERLLSCQQELDDLK-----ERYKELDDE 857
+ KRS S V+ ++ E+S L + Q+E+ LK +R +E D E
Sbjct: 498 IANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHE 557
Query: 858 CETCAEYLQERDEQCARLKKEKLSLE---QQVSNLKEQIRTQQPVERQAKFADVAVNTDE 914
E Q E A +K K+ LE Q + + + VE++ + T E
Sbjct: 558 VLDQKEMKQMEGEGIAPIKM-KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSE 616
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTI-----EELRYKKQDLKNTVTKMQKAMEKYTK 969
+ +L+ V+ S + +K+ + I +EL K + KA E Y
Sbjct: 617 E-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIY-- 673
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+K + K KE+ + +EE K K D ++R++ ++KE + E+
Sbjct: 674 -EKNLDEKAKEISNLNQLIEEFK---KNADNNSSAFTALSEERDQLLSQVKELSMVTEL 728
Score = 35.5 bits (78), Expect = 1.1
Identities = 75/438 (17%), Positives = 179/438 (40%), Gaps = 42/438 (9%)
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
E + H+K++ + I +++ ++QE ++L + +L + + A + ++
Sbjct: 90 EEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA------QSSTEM 143
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E QL +++ + A+L S + EQ A +
Sbjct: 144 EEFVMMKQQLQEKEEFISTLQAQL-SQTQAEQAAQLSSMQQVVREKDARFETQVRLHE-- 200
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
DE L ++ ++ + V+ ++ + +E L+ Q +D L++ + + +
Sbjct: 201 DELLQLVTQADVETEMQQKLRVL-QRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 259
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
+ LQ+ + + L + + E++ S + + + ER+ F N E+ +L
Sbjct: 260 QQLQQMEAEHNTL-RNTVETEREESKILLEKMELEVAERKLSFH----NLQEEMHHLLEQ 314
Query: 923 VVDRMSYDAEVEKNKRLMK-----TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK 977
AE+E ++ +EE L+ T ++Q A + KD+ +
Sbjct: 315 FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACD--ALKDQNSKLL 372
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLK----QREEQCKRLKEAKIALEIVDKLS 1033
+ + E + ++Q +L ++ + +++L Q+ E + + E ++
Sbjct: 373 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 432
Query: 1034 NQKVA-LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICK 1092
+ +A L+K++ L N G+ ++ + ++ ++ EN+KL IT+ +
Sbjct: 433 EENIASLQKRVVELEN----------EKGALLLSSIELEELKAENEKLSSQ----ITLLE 478
Query: 1093 KRGKTG-ANRENEDPSDV 1109
+ +TG A+RE + S V
Sbjct: 479 AQNRTGEADREVSEISIV 496
>BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containing
linker protein 1 protein.
Length = 1392
Score = 73.3 bits (172), Expect = 4e-12
Identities = 179/883 (20%), Positives = 340/883 (38%), Gaps = 73/883 (8%)
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKR 304
L +E D R + + I+ L L + E + ++ T E
Sbjct: 367 LLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVE 426
Query: 305 NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD--VFEILMDNIINKYQI- 361
LN L E E +K +D R ++ + D E T S + E+ D + ++
Sbjct: 427 LLNQLEE-----EKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ---KERIH-- 416
+L LE K GD++ S L+ ++ L + + L+ +E H
Sbjct: 482 ELRRRLES-NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK 540
Query: 417 EISSAVTI-DIVKKENE-LKEIL------TKECLKLSKLKIDIPRDLDQDLPAHKKI--- 465
EI + T + + KENE LK L + + L K K++ Q K+
Sbjct: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 600
Query: 466 ------TILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
T F L TQ E R DY+ E E L+ + + +A ++
Sbjct: 601 KGLGAETAEFAELKTQIEKMRLDYQHEIENLQNQQNSERAAHAKEMEALRAKL--MKVIK 658
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK-NEE-KMLSLSEK 577
E N ++++ +L K + E LN ++ ++ L++ AK NE+ K++
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 578 DNKLTE-LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
K TE + ++ L++ ++ KS E + +LE + + IK E++K
Sbjct: 719 QPKATEEKLLDLDALRKASSEGKS-------EMKKLRQQLEAAEKQIKH--LEIEKN--- 766
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ 696
+ + L++NL+ Q +E E+ I EK AE
Sbjct: 767 ---AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK----ELQI-LKEKFAEAS 818
Query: 697 NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQK 756
+ +Q+ +QE +KE + N L++ E L+ + E QL K
Sbjct: 819 EEAVS-VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD- 815
+ +E IAE+ + + ++ + T +EN + D
Sbjct: 878 EKLENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 816 ----DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE-TCAEYLQERDE 870
+ ++ + + E +L+ +L +++++ + +EL E +E + +E
Sbjct: 937 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEE 996
Query: 871 QCARLKKEKLSLEQQVSNLKEQ----IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
L+K L E ++ +E+ ++ + + +QA A A ++ + + ++
Sbjct: 997 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEK 1056
Query: 927 MSYDAEVEKNKRL-MKTIEEL-RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
A +E K+ K EL K+ +LKN V ++ K+ E T ++++ E RKE+E
Sbjct: 1057 TETLASLEDTKQTNAKLQNELDTLKENNLKN-VEELNKSKELLTVENQKMEEFRKEIETL 1115
Query: 985 KAELEELKQRYKELDEECETCAEYL-KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
K + Q+ L EE AE L + R+E K + + ++L K K I
Sbjct: 1116 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1175
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQ-NQQITDVMKENQKLKKMNA 1085
+ S T + + + + ++ + E L+ NA
Sbjct: 1176 KDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1218
Score = 67.3 bits (157), Expect = 3e-10
Identities = 166/921 (18%), Positives = 373/921 (40%), Gaps = 83/921 (9%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K +E L +++++ + T + E+++E + ++V E L ++D L+
Sbjct: 360 KQQHIEQLLAERDLERAEVAKATSH--VGEIEQELALARDGHDQHVLE---LEAKMDQLR 414
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
E ++ ++L + E + K+ Q +++E I + K +
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVED----LQFRVEEESITKGDLEVATVSEKSRIMELE 470
Query: 233 SNTSTRYNKICTLQSELD----AGREDCK-ELCEDFTSIKNHLEL----HEPNMTMDLDE 283
+ + R ++ L+ L+ AG D L ++ +S++ LE+ H+ +T L E
Sbjct: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT-SLKE 529
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQL---INNESKKSKDHIDRYKDSLLAVLDAEF 340
G E K +K + L+ +E L + + +K++ D I +K L + +
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH- 588
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
+++ ++ + + E+ + K++ D L++ + +++ +E
Sbjct: 589 -QQAMEELKVSFSKGLGAETAEFAELKTQIEKMRLDYQHEIENLQNQQNSERAAHAKEME 647
Query: 401 KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLP 460
A ++++ KE+ + + A+ + K E++ + KL + +I + ++L+
Sbjct: 648 ALRA-KLMKVIKEKENSLE-AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV-KELEVLQA 704
Query: 461 AHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+ T + D +Q + + ++ + LR + K+ LE
Sbjct: 705 KCNEQTKVIDNFTSQPKATEEKL-LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 521 AHNEVKSLHEELTK------LYKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKMLS 573
N S +T+ L + + EN + ++ +K L +E+ LK A+ E+ +S
Sbjct: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
Query: 574 ----LSEKDNKLTELVSTINGLKEENNSLK-SLNDVITREKETQASELERSCQVIKQNGF 628
+ E NKL + N L + L+ +L D+ + +E ER Q+IK
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD----EREEQLIKAK-- 877
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA-LKEQCEEKTRDCSRLEINIK 687
+K++ DI DE + L E+++ L+ + + + S L+ +I+
Sbjct: 878 --EKLENDIAEIMKMSGDNSSQLTKMNDELR-LKERDVEELQLKLTKANENASFLQKSIE 934
Query: 688 THEKTAE-IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
AE Q + +++ +E ++ + E K+ N+ + LK Y+ A + ++
Sbjct: 935 DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKH 994
Query: 747 EAVNQLTTQKDLV--EGRI--AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
E + Q QK L+ E ++ A E+ ++ +
Sbjct: 995 EEILQ-NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMT 1053
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-------RYKELD 855
E + + L+D+ + + + +E+ LKE L +EL+ KE + +E
Sbjct: 1054 KEKTETLAS--LEDTKQTNAKL--QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 856 DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV----- 910
E ET + ++ +Q + L++E + L +++ ++++ + Q +E + + +
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
Query: 911 -------NTDEDWANLHSVVVDRMSY----DAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ DE+ A+L + + DAE+EK + + + + L + V
Sbjct: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
Query: 960 MQKAMEKYTKKDKEFEAKRKE 980
++ K K K E + KE
Sbjct: 1230 LESDKVKLELKVKNLELQLKE 1250
Score = 66.5 bits (155), Expect = 5e-10
Identities = 155/769 (20%), Positives = 298/769 (38%), Gaps = 66/769 (8%)
Query: 28 DGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQ 87
+ KSK ++ + S+ I L S T Q+++E + L + E ++K Q
Sbjct: 557 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGAETAEFAELKTQ 616
Query: 88 KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD-----KEIKNLTDSLKTKSKKINE 142
+ YQ+ I Q + + EME L KE +N +++++K K +
Sbjct: 617 IEKMRLDYQHEIENLQNQQNSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 676
Query: 143 --LQEENDTLSNLIMENV---------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVN- 190
L E DTL+ L + + + K +D+ + +K +DL+ L
Sbjct: 677 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQPKATEEKLLDLDALRKA 736
Query: 191 ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD 250
SE K K + Q + E I+ L I + N S +++ TR EL
Sbjct: 737 SSEGKSEMKKLRQQLEAAEKQIKHLEI-------EKNAESSKASSITR---------ELQ 780
Query: 251 AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLS 310
L E+ + + E E + + L EK E +E +AV V ++ +N L
Sbjct: 781 GRELKLTNLQENLSEVSQVKETLEKELQI-LKEKFAEASE---EAVSVQRSMQETVNKLH 836
Query: 311 EQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
++ + +++ +++ LA ++A+F D E + K + D+ EI++
Sbjct: 837 QK--EEQFNMLSSDLEKLREN-LADMEAKF--REKDEREEQLIKAKEKLENDIAEIMKMS 891
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
L + EL+ + L +L + + L+ E + + + KK
Sbjct: 892 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 431 NELKEILTKECLKLSKLKIDIPRDLDQDLPA-HKKIT----ILFDALITQYELSRTDYEI 485
E K+ L ++ L K K++ + Q+L A +++ T + ++ + + D E
Sbjct: 952 EEEKKELERKLSDLEK-KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE- 1009
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+K K E + T E+A ++ + +E T+ S D
Sbjct: 1010 DKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLS----LSEKDNKLTELVSTINGLKEENNSLKSL 601
N L E+D LK KN E++ L+ ++ K+ E I LK+
Sbjct: 1070 NAK----LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1125
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ E A EL RS + + +L++ ++ + DE K+
Sbjct: 1126 LSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1184
Query: 662 LEQNLALKEQ-CEEKTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
L++++++ EK + +L E+ + E + ++ Q E DK+ +E +
Sbjct: 1185 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVV----QTLESDKVKLELK 1240
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
K EL K + + D ++ + Q +Q D + I +L+
Sbjct: 1241 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQ-ESQIDFLNSVIVDLQ 1288
Score = 63.7 bits (148), Expect = 4e-09
Identities = 125/613 (20%), Positives = 264/613 (43%), Gaps = 59/613 (9%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGE--- 80
R++LD K+++ +++E + KLQ++ I K + L+ NE ++ + +
Sbjct: 668 RSKLD--KAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFTSQPKA 722
Query: 81 ----LFDIKE-QKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT 135
L D+ +K++ EGK + L Q + QIK LE+E + + ++T L+
Sbjct: 723 TEEKLLDLDALRKASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAESSKASSITRELQG 781
Query: 136 KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENK 195
+ K+ LQE +S + + L KE+ LK+ +++ + +++ + E+ NK
Sbjct: 782 RELKLTNLQENLSEVSQV-------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 834
Query: 196 IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRED 255
+ K + + N++ S L KL +++D R + +L +E
Sbjct: 835 LHQK------EEQFNMLSS-------DLEKLRENLADMEAKFREKD--EREEQLIKAKEK 879
Query: 256 CKELCEDFTSIK--NHLELHEPNMTMDLDEKLGENNEFE-TKAVKVMSEIKRNLNSLSEQ 312
+ + + N +L + N + L E+ E + + TKA + S +++++ ++ +
Sbjct: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
Query: 313 LINNESKKSKDHIDRYKD--SLLAVLDAEFGTTSLDVFEILM--DNIINKYQIDLDEILE 368
++ + +K H + K+ L+ L+ + T+ E+ + ++ + +EIL+
Sbjct: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
K D + +LK E+ + L +L E + + + + E + + + K
Sbjct: 1000 NLQKTLLDTED---KLKGAREENSGLLQELEELRKQAD--KAKAAQTAEDAMQIMEQMTK 1054
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
++ E L +KL+ ++ + +L +++ + L + + E KE
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME---EFRKE 1111
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS---LHEELTKLYKSKVDENNA 545
L+ A+ + L + +EV S L EE + L ++
Sbjct: 1112 IETLKQAAAQKSQQLSALQEENVKLA-EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1170
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
IK EE +L+ +I+ L+EKD +L +L + + L+ EN S KSL+ V+
Sbjct: 1171 ESKFIKDADEEKASLQKSISITSAL---LTEKDAELEKLRNEVTVLRGENASAKSLHSVV 1227
Query: 606 -TREKETQASELE 617
T E + EL+
Sbjct: 1228 QTLESDKVKLELK 1240
Score = 40.7 bits (91), Expect = 0.028
Identities = 44/241 (18%), Positives = 108/241 (44%), Gaps = 15/241 (6%)
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE------DWANLHSVVVDRMSY 929
K E L QQ+ ++QI+ + +E+ A+ + + T E NL + +
Sbjct: 741 KSEMKKLRQQLEAAEKQIKHLE-IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
+EK +++K E+ ++ + MQ+ + K +K+++F +LE + L
Sbjct: 800 KETLEKELQILK--EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 857
Query: 990 ELKQRYKELDEECETCAEYLKQREEQ-CKRLKEAKIALEIVDKLSNQKVALEKQIE--SL 1046
+++ +++E DE E + ++ E + +K + + K++++ E+ +E L
Sbjct: 858 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 1047 SNTPVSNSTMYVATG---SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANREN 1103
T + + ++ + Q + K++++ KK + ++ +K+ +T N+
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
Query: 1104 E 1104
E
Sbjct: 978 E 978
Score = 37.9 bits (84), Expect = 0.20
Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 10/148 (6%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKY 95
+++ Q +K ++S I + + SL++S + + L + EL ++ + + L G
Sbjct: 1158 SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG-- 1215
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
E + L S +++LE + + + ++KNL LK ++++ DT ++
Sbjct: 1216 -----ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQAD-ED 1269
Query: 156 ENVTES--DNLNKEVDDLKKNNECLTQK 181
E ES D LN + DL++ N+ L K
Sbjct: 1270 ERAQESQIDFLNSVIVDLQRKNQDLKMK 1297
>AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22037 fis, clone HEP08868. ).
Length = 746
Score = 73.3 bits (172), Expect = 4e-12
Identities = 137/723 (18%), Positives = 290/723 (40%), Gaps = 55/723 (7%)
Query: 30 AKSKNDNIIETQSNPIKLQDSGT-ITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQK 88
++ KND I+ Q+ L D+ +T K L+ +++ +LE+ G + K
Sbjct: 73 SQEKNDLTIQLQAEQENLMDAEERLTWMMKTKMDLESQISDMRERLEEEEGMAASLSAAK 132
Query: 89 SALEGKYQNLILETQTRDL--LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEE 146
LEG+ +L RDL L + + E E D +++ LT L + I +LQ+E
Sbjct: 133 RKLEGELSDL-----KRDLEGLETTLAKTEKEKQALDHKVRTLTGDLSLREDSITKLQKE 187
Query: 147 NDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCK 206
L L + + + +V+ L KNN L+ + +LE E E KI + A+ K
Sbjct: 188 KRALEELHQKTLDDLQAEEDKVNHLTKNNSKLSTQIHELEDNW-EQEKKIRAEVEKARRK 246
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDF-TS 265
+ +L ++ DN L+++ RS D + + + +++ ED + L
Sbjct: 247 AESDLKMTI----DN-LNEMERSKLDLEEVVKKRDLEI--NSVNSKYEDEQSLNSTLQRK 299
Query: 266 IKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDH 324
+K H + + E ++ + + E K + +++R L + Q S K H
Sbjct: 300 LKEHQDRIEELEEELEAERAMRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRKKH 359
Query: 325 IDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSEL 384
+D + V + + L+ + +M I+ ++ I + + + + L
Sbjct: 360 VDSMAELTEHVESLQRVKSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSL 419
Query: 385 KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
N K+A L + N I I + R+ +S ++ + + ++ L +IL +
Sbjct: 420 SEANAKVAEL------ERNQAEINAI-RTRLQAENSELSREYEESQSRLNQILRIKTSLT 472
Query: 445 SKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXX 504
S++ D R LD++ + + T + T+++L ++ KE+L E G +
Sbjct: 473 SQVD-DYKRQLDEE--SKSRSTAVVSLANTKHDL-----DLVKEQLEEEQGGKSELQRLV 524
Query: 505 XXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIA 563
E +A + L E KL A L + +E A +
Sbjct: 525 SKLNTEVTTWRTKYETDAIQRTEELEETKRKL--------AARLQEAEEAAETAQARAAS 576
Query: 564 IAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
+ KN++++ +E ++ +L E+ N+ + D R + +E ++ C+ +
Sbjct: 577 LEKNKQRL--QAEVEDLTIDL--------EKANAAAAALDKKQRLFDKMLAEWQQKCEEL 626
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
+ E+D + + M + +S+ ++N L+E+ ++
Sbjct: 627 Q---VEVDSSQKECRMYMTESFKIKTAYEESLEHLESVKKENKTLQEEIKDLIDQLGEGG 683
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
++ +K + LQ ++E + +E+K+ + + +K D D + + +
Sbjct: 684 RSVHELQKLKKKLEMEKEELQVALEEAESSLEVEESKVIRIQLELAQVKADIDRRIHEKK 743
Query: 744 SSR 746
+
Sbjct: 744 KKK 746
Score = 70.5 bits (165), Expect = 3e-11
Identities = 111/546 (20%), Positives = 221/546 (40%), Gaps = 35/546 (6%)
Query: 564 IAKNEEKMLSLSEKDNK-LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV 622
+A+ EE+M + E+ K + + +N +KE L+ +++EK ++L Q
Sbjct: 34 VARQEEEMKAKEEELRKAMAQTQELVNKVKE----LEEKTATLSQEK----NDLTIQLQA 85
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL 682
++N + ++ ++ +E + + A K + E + D R
Sbjct: 86 EQENLMDAEERLTWMMKTKMDLESQISDMRERLEEEEGMAASLSAAKRKLEGELSDLKRD 145
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL 742
++T E + + + + + D L +E + +L + AL+ + + DL
Sbjct: 146 LEGLETTLAKTEKEKQALDHKVRTLTGDLSL---REDSITKLQKEKRALEELHQKTLDDL 202
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
++ + VN LT + +I ELE + E+
Sbjct: 203 QAEEDKVNHLTKNNSKLSTQIHELEDNWEQEKKIRAEVEKARRKAESDLKMTIDNLNEME 262
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
DL E K D S++ + E S L L Q++L + ++R +EL++E E
Sbjct: 263 RSKLDLEEVVKKRDLEINSVNSKYEDEQS-LNSTL---QRKLKEHQDRIEELEEELE-AE 317
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
++ + EQ + + E L L +++ Q R+ K D E +L V
Sbjct: 318 RAMRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRK-KHVDSMAELTEHVESLQRV 376
Query: 923 VVDRMSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+++EK+K++MK I++L + ++ + + + K E AK EL
Sbjct: 377 -------KSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSEANAKVAEL 429
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-AKIALEIVDKLSNQKVALE 1040
E +AE+ ++ R + E E EY EE RL + +I + ++ + K L+
Sbjct: 430 ERNQAEINAIRTRLQA--ENSELSREY----EESQSRLNQILRIKTSLTSQVDDYKRQLD 483
Query: 1041 KQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKL-KKMNAKLITICKKRGKTGA 1099
++ +S S VS + Q ++ E Q+L K+N + +T + + +T A
Sbjct: 484 EESKSRSTAVVSLANTKHDLDLVKEQLEEEQGGKSELQRLVSKLNTE-VTTWRTKYETDA 542
Query: 1100 NRENED 1105
+ E+
Sbjct: 543 IQRTEE 548
Score = 62.1 bits (144), Expect = 1e-08
Identities = 126/723 (17%), Positives = 282/723 (39%), Gaps = 38/723 (5%)
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE--LKSVNEKLASLNSQLIEKENACN 406
+++ N+ Q+ + Y KV+ LN E +K+ E+L +Q E N
Sbjct: 4 KVIQQNVRKFLQLRFWGWWKLYNKVKPLLNVARQEEEMKAKEEELRKAMAQTQELVNKVK 63
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR---DLDQDLPAHK 463
L + + + + +TI + ++ L + + + K K+D+ D+ + L +
Sbjct: 64 ELEEKTATLSQEKNDLTIQLQAEQENLMDA-EERLTWMMKTKMDLESQISDMRERLEEEE 122
Query: 464 KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
+ A + E +D + + E L + E++
Sbjct: 123 GMAASLSAAKRKLEGELSDLKRDLEGLETTLAKTEKEKQALDHKVRTLTGDLSLREDSIT 182
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK------NEEKMLSLSEK 577
+++ L +L++ +D+ A + + L++ L I + E+K+ + EK
Sbjct: 183 KLQKEKRALEELHQKTLDDLQAEEDKVNHLTKNNSKLSTQIHELEDNWEQEKKIRAEVEK 242
Query: 578 DNKLTE--LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD-KMK 634
+ E L TI+ L E S L +V+ ++++ + + + + + L K+K
Sbjct: 243 ARRKAESDLKMTIDNLNEMERSKLDLEEVV-KKRDLEINSVNSKYEDEQSLNSTLQRKLK 301
Query: 635 A--DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI-KTH-E 690
D + ++ + + L L+ + EE + K H +
Sbjct: 302 EHQDRIEELEEELEAERAMRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRKKHVD 361
Query: 691 KTAEIQNRM--IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
AE+ + + R++ ++++D ++ + LN + K + +A V+ LE S
Sbjct: 362 SMAELTEHVESLQRVKSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSE 421
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRD 807
N + + + I + + ++ E + + D+ R
Sbjct: 422 ANAKVAELERNQAEINAIRTRLQAENSELSREYEESQSRLNQILRIKTSLTSQVDDYKRQ 481
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC-AEYLQ 866
L E K + S++ + ++ +KE+L Q +L+ +L+ E T +Y
Sbjct: 482 LDEESKSRSTAVVSLAN-TKHDLDLVKEQLEEEQGGKSELQRLVSKLNTEVTTWRTKYET 540
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
+ ++ L++ K L ++ +E T Q A+ A + N A + + +D
Sbjct: 541 DAIQRTEELEETKRKLAARLQEAEEAAETAQ-----ARAASLEKNKQRLQAEVEDLTIDL 595
Query: 927 MSYDAE---VEKNKRLM-KTIEELRYKKQDLKNTVTKMQKAMEKYT----KKDKEFEAKR 978
+A ++K +RL K + E + K ++L+ V QK Y K +E
Sbjct: 596 EKANAAAAALDKKQRLFDKMLAEWQQKCEELQVEVDSSQKECRMYMTESFKIKTAYEESL 655
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ LE K E + L++ K+L ++ + + ++ K+L+ K L++ + + +
Sbjct: 656 EHLESVKKENKTLQEEIKDLIDQLGEGGRSVHELQKLKKKLEMEKEELQVALEEAESSLE 715
Query: 1039 LEK 1041
+E+
Sbjct: 716 VEE 718
Score = 54.8 bits (126), Expect = 2e-06
Identities = 125/672 (18%), Positives = 277/672 (41%), Gaps = 59/672 (8%)
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLS----NLIMENVTESDNL---NKEV 168
E E K++E++ + K+ EL+E+ TLS +L ++ E +NL + +
Sbjct: 38 EEEMKAKEEELRKAMAQTQELVNKVKELEEKTATLSQEKNDLTIQLQAEQENLMDAEERL 97
Query: 169 DDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENL--IQSLHIGYDNTLSKL 226
+ K L + D+ + + E E + A+ KL+ L ++ G + TL+K
Sbjct: 98 TWMMKTKMDLESQISDMRERLEEEEGMAASLS-AAKRKLEGELSDLKRDLEGLETTLAK- 155
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
++ +K+ TL +L + +L ++ +++ ELH+ + DL +
Sbjct: 156 ----TEKEKQALDHKVRTLTGDLSLREDSITKLQKEKRALE---ELHQKTLD-DLQAEED 207
Query: 287 ENNEFETKAVKVMSEI-KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL 345
+ N K+ ++I + N E+ I E +K++ + + L +D +
Sbjct: 208 KVNHLTKNNSKLSTQIHELEDNWEQEKKIRAEVEKAR---RKAESDLKMTID---NLNEM 261
Query: 346 DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ ++ ++ ++ K ++++ + KY Q + +LK +++ L +L E E A
Sbjct: 262 ERSKLDLEEVVKKRDLEINSVNSKYEDEQSLNSTLQRKLKEHQDRIEELEEEL-EAERAM 320
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKE-ILTKECL--KLSKLKIDIPRDLDQDLPAH 462
+I++ R E +++K EL+E L E L K +D +L + + +
Sbjct: 321 R-AKIEQNRKRE------AELLKLRRELEEAALQSEATASTLRKKHVDSMAELTEHVESL 373
Query: 463 KKI--TILFDALITQYE---LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+++ + D + + E L+ + I+K K+ E K +
Sbjct: 374 QRVKSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSEANAKVAELERNQ 433
Query: 518 LE--EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAI-AKNEEKMLSL 574
E +++ + EL++ Y+ N L + L+ ++D K + +++ + ++
Sbjct: 434 AEINAIRTRLQAENSELSREYEESQSRLNQILRIKTSLTSQVDDYKRQLDEESKSRSTAV 493
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITR-EKETQASELERSCQVIKQNGFELDKM 633
N +L L+EE L ++++ E + I Q EL++
Sbjct: 494 VSLANTKHDLDLVKEQLEEEQGGKSELQRLVSKLNTEVTTWRTKYETDAI-QRTEELEET 552
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
K + A SL + L+ + E+ T D + +K
Sbjct: 553 KRKL---AARLQEAEEAAETAQARAASLEKNKQRLQAEVEDLTIDLEKANAAAAALDKKQ 609
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESSREAV 749
+ ++M+ Q++ +E L +E ++ E +T ++ +K Y+ +++ LES ++
Sbjct: 610 RLFDKMLAEWQQKCEE---LQVEVDSSQKECRMYMTESFK-IKTAYEESLEHLESVKKEN 665
Query: 750 NQLTTQ-KDLVE 760
L + KDL++
Sbjct: 666 KTLQEEIKDLID 677
Score = 53.6 bits (123), Expect = 4e-06
Identities = 123/688 (17%), Positives = 265/688 (38%), Gaps = 47/688 (6%)
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
++ ++E + + + A T ++V K EL+E + + L I + + + + A +++T
Sbjct: 41 MKAKEEELRK-AMAQTQELVNKVKELEEKTATLSQEKNDLTIQLQAEQENLMDAEERLTW 99
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
+ T+ +L ++ +E+L E G A ++ LE +
Sbjct: 100 MMK---TKMDLESQISDM-RERLEEEEGMAASLSAAKRKLEGELSDLKRDLEGLETTLAK 155
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS-LSEKDNKLTELVS 586
+E L KV +L+L + ++ K A+ + +K L L +++K+ L
Sbjct: 156 TEKEKQAL-DHKVRTLTGDLSLREDSITKLQKEKRALEELHQKTLDDLQAEEDKVNHLTK 214
Query: 587 TINGLKEENNSLKS---LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ L + + L+ I E E + E ++ N E+++ K D+
Sbjct: 215 NNSKLSTQIHELEDNWEQEKKIRAEVEKARRKAESDLKMTIDNLNEMERSKLDLEEVVKK 274
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEI-QNRMI- 700
++ +SL N L+ + +E LE ++ A+I QNR
Sbjct: 275 RDLEINSVNSKYEDEQSL---NSTLQRKLKEHQDRIEELEEELEAERAMRAKIEQNRKRE 331
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
L K +E ++ ++ E + L K+ + + +ES + ++L K +++
Sbjct: 332 AELLKLRRELEEAALQSEATASTLRKKHVDSMAEL---TEHVESLQRVKSKLEKDKQVMK 388
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
I +L + + T Q + + + + N + E + + +
Sbjct: 389 AEIDDLNASMETIQKSKMNAEAHVRKLED----------SLSEANAKVAELER-NQAEIN 437
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
+I +E S+L Q L+ + L + + L E + +
Sbjct: 438 AIRTRLQAENSELSREYEESQSRLNQILRIKTSLTSQVDDYKRQLDEESKSRSTAVVSLA 497
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE-VEKNKRL 939
+ + + +KEQ+ +Q + + + +NT+ V R Y+ + +++ + L
Sbjct: 498 NTKHDLDLVKEQLEEEQGGKSELQRLVSKLNTE--------VTTWRTKYETDAIQRTEEL 549
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
+T +L + Q+ + Q K + +A E+ED +LE+ LD
Sbjct: 550 EETKRKLAARLQEAEEAAETAQARAASLEKNKQRLQA---EVEDLTIDLEKANAAAAALD 606
Query: 1000 EECETCAEYLKQREEQCKRLK-----EAKIALEIVDKLSNQKVALEKQIESLSNTPVSNS 1054
++ + L + +++C+ L+ K + + K A E+ +E L + N
Sbjct: 607 KKQRLFDKMLAEWQQKCEELQVEVDSSQKECRMYMTESFKIKTAYEESLEHLESVKKENK 666
Query: 1055 TMYVATGSAIVQNQQITDVMKENQKLKK 1082
T+ I Q + + E QKLKK
Sbjct: 667 TLQEEIKDLIDQLGEGGRSVHELQKLKK 694
Score = 37.5 bits (83), Expect = 0.26
Identities = 29/127 (22%), Positives = 62/127 (48%), Gaps = 2/127 (1%)
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
K + ++++E +AK +EL A+ +EL + KEL+E+ T ++ Q + +E
Sbjct: 29 KPLLNVARQEEEMKAKEEELRKAMAQTQELVNKVKELEEKTATLSQEKNDLTIQLQAEQE 88
Query: 1022 AKI-ALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVMKENQK 1079
+ A E + + K+ LE QI + M + +A + + +++D+ ++ +
Sbjct: 89 NLMDAEERLTWMMKTKMDLESQISDMRERLEEEEGMAASLSAAKRKLEGELSDLKRDLEG 148
Query: 1080 LKKMNAK 1086
L+ AK
Sbjct: 149 LETTLAK 155
>L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein.
Length = 1300
Score = 72.9 bits (171), Expect = 6e-12
Identities = 129/661 (19%), Positives = 265/661 (40%), Gaps = 60/661 (9%)
Query: 48 QDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ--- 103
+D+ CK + Q + N+ + ++ + ++++ + + K ETQ
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQ 405
Query: 104 -----TRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK-SKKINELQEENDTLSNLIMEN 157
R+ + ++I L+ EN + N T+ L++K S ++N+L+++ L N + E
Sbjct: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
Query: 158 V-------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK 208
+ N + LK + ++ +++ + + +E++ +++ ++ K
Sbjct: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK 525
Query: 209 ENLIQSLHIGYDNTL---SKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDF 263
EN +QSLH +TL +L + + + R NK +LQ ++ E + L
Sbjct: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
Query: 264 TSIKNHL--ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESK 319
+ + + + +L + + E ++ + ++ + L S E+L I N +
Sbjct: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K + + + A + + D+ I + L + + LN+
Sbjct: 646 LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 705
Query: 380 CTSELKSVNEKLASL-----NSQLIEKENACNILRIQK-ERIHEISSAVTIDIVKKENEL 433
LKS +KL +L N ++E+ C + +K + + E+ I + KE EL
Sbjct: 706 QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
I T+ S L ++ QDL A + + F +L+ EL + +E +
Sbjct: 766 NAIRTEN----SSLTKEV-----QDLKAKQNDQVSFASLVE--ELKKVIHE--------K 806
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
G K+V T+++ E+K+L EE+ + K + L++ +
Sbjct: 807 DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ----LSITSKV 862
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKE 610
E + LK + L EK+ L + L+EEN SLK+ + + ++
Sbjct: 863 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 922
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ AS+ E V+K+ EL +++A + DE K Q LK+
Sbjct: 923 SSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
Query: 671 Q 671
Q
Sbjct: 983 Q 983
Score = 70.5 bits (165), Expect = 3e-11
Identities = 209/1066 (19%), Positives = 418/1066 (39%), Gaps = 94/1066 (8%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
++K + + K E K+++ +L +T ++ S+ ++L + +L K+K + D+L
Sbjct: 263 IQKSGTKKLKTETDKENAEVKFKDFLLSLKT--MMFSEDEALCVVDLLKEKS-GVIQDAL 319
Query: 134 KTKSKK-----INELQEENDTLSNLIMENVTESDN---LNKEVDDLKKNNECLTQKCID- 184
K SK I++LQE++ L+ + + D L +E+ K+ + + + D
Sbjct: 320 KKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDR 379
Query: 185 ---LEKLVNESENKIGPK-NICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
LEK N +NKI Q ++K ++ L + N + D+ ++T N
Sbjct: 380 IGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT-N 438
Query: 241 KICTLQS-ELDAGREDCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAV 296
++ + QS EL+ R+D L + T L E+ + N + + E E +
Sbjct: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWE 498
Query: 297 KVMSEIKRNL-------NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
+V S I++ L + + E++ H + D+L++ E L E
Sbjct: 499 EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLH-SKLTDTLVSKQQLEQRLMQLMESE 557
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
N Q+ + +ILE+ ++ + + S++ + + AS+ ++ + K A +
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAA--QTSASVLAEELHKVIAEKDKQ 615
Query: 410 IQKERIHEISSAVTID-IVKKENELKEI------LTKECLKLSKLKIDIPRDLDQDLPAH 462
I++ E S A D + KE ELK+I L E KL L + +
Sbjct: 616 IKQT---EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQ 672
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAH 522
+ + + D + E + + + E+ ++ KA+ +
Sbjct: 673 QSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQ-PNKDVVE 731
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILS--EEIDALKIAIAKNEEKMLSLSEKDNK 580
K + E+ KL K E LI++ + EE++A++ + +++ L K N
Sbjct: 732 QMEKCIQEKDEKL---KTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
Query: 581 LTELVSTINGLK----EENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
S + LK E++ +KS+ +++ E A++ E++ Q +KQ L + +
Sbjct: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK-EKTVQDLKQEIKALKEEIGN 847
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ 696
+ + + K EQ +K EEK +D + ++ ++ E
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Query: 697 NRMIMRL-QKQIQEDDKL--FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ + Q ++E F E E L E N+ + L+ DL S + + +
Sbjct: 908 KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 967
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
+ L + +I +L+ +Q ++ D +D E+ +
Sbjct: 968 DENKLFKSQIEQLKQQ-NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1026
Query: 814 LDDSPKRSISVISDSEVSQLKERL---------LSCQQELDDLKERYKEL------DDEC 858
++ ++ + E ++ ++L LS + L +++ KE +E
Sbjct: 1027 KKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV 1086
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA--VNTDEDW 916
+ L+E DE L+ L E+ S L E Q ++R + + V DE
Sbjct: 1087 KVLEHKLKEADEMHTLLQ---LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1143
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
+ + S + E+E+ + K IE LR +++ L+ + K + Y
Sbjct: 1144 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYV-------- 1195
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
E+ + KA+L E + + E + A L + +Q L ++KI K +
Sbjct: 1196 --TEVRELKAQLNETLTKLRTEQNERQKVAGDL-HKAQQSLELIQSKIV-----KAAGDT 1247
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
+E S TM V+ + Q QQ+ + NQ+L K
Sbjct: 1248 TVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV--NQQLTK 1291
Score = 65.3 bits (152), Expect = 1e-09
Identities = 121/596 (20%), Positives = 255/596 (42%), Gaps = 45/596 (7%)
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTEL 584
KS ELT L +++ L+ + E+ A K + ++M++ E+ N +T +
Sbjct: 321 KSSKGELTTLIHQLQEKDK----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM 376
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI-LMXXXX 643
I L++E+N + N + +ETQ +++ QV +Q E+ +K + ++
Sbjct: 377 KDRIGTLEKEHNVFQ--NKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAV 433
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E L + L + EKT + E+ K E+ A +L
Sbjct: 434 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-------QL 486
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRD----YDAAVKDLESSREAVNQLTTQKDLV 759
+ Q+QE ++ + E ++ + + T ++EA ++D + A +++S + K +
Sbjct: 487 KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL 546
Query: 760 EGRIAEL-ESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD--LGEN-P 812
E R+ +L ES+ + E++ + + L E
Sbjct: 547 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH 606
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
K+ + I DS S+ ++RL S ++EL D++ L E + E+
Sbjct: 607 KVIAEKDKQIKQTEDSLASE-RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
Query: 873 ARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
L+K + S+ + ++ L+EQ++ E K + + D++ A L S V +
Sbjct: 666 HELEKMQQSVYVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKA-LKSEVQKLQTL 720
Query: 930 DAEVEKNKRLMKTIEE-LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E + NK +++ +E+ ++ K + LK ++ + + K++E A R E E+
Sbjct: 721 VSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 779
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVA---LEKQIE 1044
++LK + + E K E+ ++K + LE + K++N++ L+++I+
Sbjct: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 839
Query: 1045 SLSNTPVSNSTMYVATGSAIVQN-QQITDVMK-ENQKLKKMNAKLITICKKRGKTG 1098
+L + N + A +I Q++ +++K + +++ M A L K TG
Sbjct: 840 ALKE-EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 894
Score = 58.8 bits (136), Expect = 1e-07
Identities = 152/798 (19%), Positives = 314/798 (39%), Gaps = 68/798 (8%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ L+ + + K+ E+++L L +L++ L + V + ++L +V D+
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 575
Query: 173 KNNECLTQKCIDLEKLV--NESENKIGP---KNICAQCKLKENLIQSLHIGYDNTLSKLN 227
+ NE L + + S + + K I + K + SL D SK
Sbjct: 576 EQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEE 635
Query: 228 --RSISDSN--TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE 283
+ I + N K+ L +E A + +++ + + + L E + ++
Sbjct: 636 ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
K+ E + + SE+++ +SEQ N + + + + KD L ++ T
Sbjct: 696 KMEEFKILNDQNKALKSEVQKLQTLVSEQP-NKDVVEQMEKCIQEKDEKLKTVEELLETG 754
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
+ V + +N + + + ++ ++ N+ S V E L + EK+
Sbjct: 755 LIQV--ATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE----LKKVIHEKDG 808
Query: 404 ACNILR--IQKERIHEISSAVTIDIVKKE-NELKEILTKECL-KLSKLKIDIP-RDLDQD 458
+ ++ E + + T+ +K+E LKE + L K +L I ++L
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 459 LPAHKKITILFDALITQYE--LSRT-----DYEIEKEKLRLETGTAKAVXXXXXXXXXXX 511
L ++ A++ + E L+ T D + E E L+
Sbjct: 869 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 928
Query: 512 XXXFDTLEEAHNEVKSLHEEL----------TKLYKSKVDENNANLNLIKILSEEIDALK 561
L+E NE+K L L T+L + DEN + I+ L ++
Sbjct: 929 EELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
Query: 562 IAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ 621
+ +EE + +SE++ +++ L + ++ LK+ + N+ R+++ +A ELE +
Sbjct: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN--ERQQQVEAVELEAK-E 1045
Query: 622 VIKQNGFELDKMKADI-----LMXXXXXXXXXXXXXXXXDEAKSLL-------EQNLALK 669
V+K+ F + +++ L +E K L E + L+
Sbjct: 1046 VLKKL-FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1104
Query: 670 EQCEEKTRDCSRLE-INIKTHEKTAEIQNRMIMRLQ---KQIQEDDKLFIEKETKLNELT 725
+CE+ + E I K + +N+ +++ K I++ F E +L L
Sbjct: 1105 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1164
Query: 726 NK---YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
++ E L+R+ + +LE + + T+ ++ ++ E + +RTEQ
Sbjct: 1165 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1224
Query: 783 XXXXXXXXXXXXXXXXX-TFGD----ENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
GD EN D+ +P+ + S K ++SV + V+QL++ L
Sbjct: 1225 DLHKAQQSLELIQSKIVKAAGDTTVIENSDV--SPETESSEKETMSVSLNQTVTQLQQLL 1282
Query: 838 LSCQQELDDLKERYKELD 855
+ Q+L KE Y+ L+
Sbjct: 1283 QAVNQQLTKEKEHYQVLE 1300
Score = 39.1 bits (87), Expect = 0.086
Identities = 77/380 (20%), Positives = 167/380 (43%), Gaps = 39/380 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+S++E LK+ + D+K++ AL+ + N+ LE + + S+++ E++NL
Sbjct: 811 KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ--ELQNL 868
Query: 121 TKDKE---------IKNLTDSLKTKSKKINELQEENDTLSNLIME----NVTESDNLN-- 165
K KE ++ L K + +LQEEN++L + E N+ E+ + +
Sbjct: 869 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 928
Query: 166 KEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
+E++ + K E ++ LE ++ E E+ + K Q EN + + + + +
Sbjct: 929 EELEIVLKEKENELKR---LEAMLKERESDLSSKTQLLQDVQDENKL------FKSQIEQ 979
Query: 226 L-NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEK 284
L ++ +++ + ++ + SE + ++ L + S+K+ +E H+ + ++
Sbjct: 980 LKQQNYQQASSFPPHEELLKVISERE---KEISGLWNELDSLKDAVE-HQRKKNNERQQQ 1035
Query: 285 LGENNEFETKAV--KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGT 342
+ E E E K V K+ ++ N + ++ KK+K+ + S V E
Sbjct: 1036 V-EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS-EEVKVLEHKL 1093
Query: 343 TSLDVFEILMDNIINKYQIDLDE---ILEKYTK-VQGDLNECTSELKSVNEKLASLNSQL 398
D L+ KY+ L E IL+K + V+ + N+ ++ ++ + + S
Sbjct: 1094 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1153
Query: 399 IEKENACNILRIQKERIHEI 418
E LR + + I +
Sbjct: 1154 TSSEQELERLRSENKDIENL 1173
>D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein.
Length = 1307
Score = 72.9 bits (171), Expect = 6e-12
Identities = 129/661 (19%), Positives = 265/661 (40%), Gaps = 60/661 (9%)
Query: 48 QDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ--- 103
+D+ CK + Q + N+ + ++ + ++++ + + K ETQ
Sbjct: 353 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQ 412
Query: 104 -----TRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK-SKKINELQEENDTLSNLIMEN 157
R+ + ++I L+ EN + N T+ L++K S ++N+L+++ L N + E
Sbjct: 413 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 472
Query: 158 V-------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK 208
+ N + LK + ++ +++ + + +E++ +++ ++ K
Sbjct: 473 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK 532
Query: 209 ENLIQSLHIGYDNTL---SKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDF 263
EN +QSLH +TL +L + + + R NK +LQ ++ E + L
Sbjct: 533 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 592
Query: 264 TSIKNHL--ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESK 319
+ + + + +L + + E ++ + ++ + L S E+L I N +
Sbjct: 593 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 652
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K + + + A + + D+ I + L + + LN+
Sbjct: 653 LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 712
Query: 380 CTSELKSVNEKLASL-----NSQLIEKENACNILRIQK-ERIHEISSAVTIDIVKKENEL 433
LKS +KL +L N ++E+ C + +K + + E+ I + KE EL
Sbjct: 713 QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 772
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
I T+ S L ++ QDL A + + F +L+ EL + +E +
Sbjct: 773 NAIRTEN----SSLTKEV-----QDLKAKQNDQVSFASLVE--ELKKVIHE--------K 813
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL 553
G K+V T+++ E+K+L EE+ + K + L++ +
Sbjct: 814 DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ----LSITSKV 869
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKE 610
E + LK + L EK+ L + L+EEN SLK+ + + ++
Sbjct: 870 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 929
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+ AS+ E V+K+ EL +++A + DE K Q LK+
Sbjct: 930 SSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 989
Query: 671 Q 671
Q
Sbjct: 990 Q 990
Score = 70.5 bits (165), Expect = 3e-11
Identities = 209/1066 (19%), Positives = 418/1066 (39%), Gaps = 94/1066 (8%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
++K + + K E K+++ +L +T ++ S+ ++L + +L K+K + D+L
Sbjct: 270 IQKSGTKKLKTETDKENAEVKFKDFLLSLKT--MMFSEDEALCVVDLLKEKS-GVIQDAL 326
Query: 134 KTKSKK-----INELQEENDTLSNLIMENVTESDN---LNKEVDDLKKNNECLTQKCID- 184
K SK I++LQE++ L+ + + D L +E+ K+ + + + D
Sbjct: 327 KKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDR 386
Query: 185 ---LEKLVNESENKIGPK-NICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
LEK N +NKI Q ++K ++ L + N + D+ ++T N
Sbjct: 387 IGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT-N 445
Query: 241 KICTLQS-ELDAGREDCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAV 296
++ + QS EL+ R+D L + T L E+ + N + + E E +
Sbjct: 446 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWE 505
Query: 297 KVMSEIKRNL-------NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
+V S I++ L + + E++ H + D+L++ E L E
Sbjct: 506 EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLH-SKLTDTLVSKQQLEQRLMQLMESE 564
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
N Q+ + +ILE+ ++ + + S++ + + AS+ ++ + K A +
Sbjct: 565 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAA--QTSASVLAEELHKVIAEKDKQ 622
Query: 410 IQKERIHEISSAVTID-IVKKENELKEI------LTKECLKLSKLKIDIPRDLDQDLPAH 462
I++ E S A D + KE ELK+I L E KL L + +
Sbjct: 623 IKQT---EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQ 679
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAH 522
+ + + D + E + + + E+ ++ KA+ +
Sbjct: 680 QSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQ-PNKDVVE 738
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILS--EEIDALKIAIAKNEEKMLSLSEKDNK 580
K + E+ KL K E LI++ + EE++A++ + +++ L K N
Sbjct: 739 QMEKCIQEKDEKL---KTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 795
Query: 581 LTELVSTINGLK----EENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
S + LK E++ +KS+ +++ E A++ E++ Q +KQ L + +
Sbjct: 796 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK-EKTVQDLKQEIKALKEEIGN 854
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ 696
+ + + K EQ +K EEK +D + ++ ++ E
Sbjct: 855 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 914
Query: 697 NRMIMRL-QKQIQEDDKL--FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ + Q ++E F E E L E N+ + L+ DL S + + +
Sbjct: 915 KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 974
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
+ L + +I +L+ +Q ++ D +D E+ +
Sbjct: 975 DENKLFKSQIEQLKQQ-NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1033
Query: 814 LDDSPKRSISVISDSEVSQLKERL---------LSCQQELDDLKERYKEL------DDEC 858
++ ++ + E ++ ++L LS + L +++ KE +E
Sbjct: 1034 KKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV 1093
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA--VNTDEDW 916
+ L+E DE L+ L E+ S L E Q ++R + + V DE
Sbjct: 1094 KVLEHKLKEADEMHTLLQ---LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1150
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
+ + S + E+E+ + K IE LR +++ L+ + K + Y
Sbjct: 1151 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYV-------- 1202
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
E+ + KA+L E + + E + A L + +Q L ++KI K +
Sbjct: 1203 --TEVRELKAQLNETLTKLRTEQNERQKVAGDL-HKAQQSLELIQSKIV-----KAAGDT 1254
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
+E S TM V+ + Q QQ+ + NQ+L K
Sbjct: 1255 TVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV--NQQLTK 1298
Score = 65.3 bits (152), Expect = 1e-09
Identities = 121/596 (20%), Positives = 255/596 (42%), Gaps = 45/596 (7%)
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTEL 584
KS ELT L +++ L+ + E+ A K + ++M++ E+ N +T +
Sbjct: 328 KSSKGELTTLIHQLQEKDK----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM 383
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI-LMXXXX 643
I L++E+N + N + +ETQ +++ QV +Q E+ +K + ++
Sbjct: 384 KDRIGTLEKEHNVFQ--NKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAV 440
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E L + L + EKT + E+ K E+ A +L
Sbjct: 441 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-------QL 493
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRD----YDAAVKDLESSREAVNQLTTQKDLV 759
+ Q+QE ++ + E ++ + + T ++EA ++D + A +++S + K +
Sbjct: 494 KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL 553
Query: 760 EGRIAEL-ESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD--LGEN-P 812
E R+ +L ES+ + E++ + + L E
Sbjct: 554 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH 613
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
K+ + I DS S+ ++RL S ++EL D++ L E + E+
Sbjct: 614 KVIAEKDKQIKQTEDSLASE-RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 672
Query: 873 ARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
L+K + S+ + ++ L+EQ++ E K + + D++ A L S V +
Sbjct: 673 HELEKMQQSVYVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKA-LKSEVQKLQTL 727
Query: 930 DAEVEKNKRLMKTIEE-LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E + NK +++ +E+ ++ K + LK ++ + + K++E A R E E+
Sbjct: 728 VSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 786
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVA---LEKQIE 1044
++LK + + E K E+ ++K + LE + K++N++ L+++I+
Sbjct: 787 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 846
Query: 1045 SLSNTPVSNSTMYVATGSAIVQN-QQITDVMK-ENQKLKKMNAKLITICKKRGKTG 1098
+L + N + A +I Q++ +++K + +++ M A L K TG
Sbjct: 847 ALKE-EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 901
Score = 58.8 bits (136), Expect = 1e-07
Identities = 152/798 (19%), Positives = 314/798 (39%), Gaps = 68/798 (8%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ L+ + + K+ E+++L L +L++ L + V + ++L +V D+
Sbjct: 523 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDIL 582
Query: 173 KNNECLTQKCIDLEKLV--NESENKIGP---KNICAQCKLKENLIQSLHIGYDNTLSKLN 227
+ NE L + + S + + K I + K + SL D SK
Sbjct: 583 EQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEE 642
Query: 228 --RSISDSN--TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE 283
+ I + N K+ L +E A + +++ + + + L E + ++
Sbjct: 643 ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 702
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
K+ E + + SE+++ +SEQ N + + + + KD L ++ T
Sbjct: 703 KMEEFKILNDQNKALKSEVQKLQTLVSEQP-NKDVVEQMEKCIQEKDEKLKTVEELLETG 761
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
+ V + +N + + + ++ ++ N+ S V E L + EK+
Sbjct: 762 LIQV--ATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE----LKKVIHEKDG 815
Query: 404 ACNILR--IQKERIHEISSAVTIDIVKKE-NELKEILTKECL-KLSKLKIDIP-RDLDQD 458
+ ++ E + + T+ +K+E LKE + L K +L I ++L
Sbjct: 816 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 875
Query: 459 LPAHKKITILFDALITQYE--LSRT-----DYEIEKEKLRLETGTAKAVXXXXXXXXXXX 511
L ++ A++ + E L+ T D + E E L+
Sbjct: 876 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 935
Query: 512 XXXFDTLEEAHNEVKSLHEEL----------TKLYKSKVDENNANLNLIKILSEEIDALK 561
L+E NE+K L L T+L + DEN + I+ L ++
Sbjct: 936 EELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 995
Query: 562 IAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ 621
+ +EE + +SE++ +++ L + ++ LK+ + N+ R+++ +A ELE +
Sbjct: 996 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN--ERQQQVEAVELEAK-E 1052
Query: 622 VIKQNGFELDKMKADI-----LMXXXXXXXXXXXXXXXXDEAKSLL-------EQNLALK 669
V+K+ F + +++ L +E K L E + L+
Sbjct: 1053 VLKKL-FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1111
Query: 670 EQCEEKTRDCSRLE-INIKTHEKTAEIQNRMIMRLQ---KQIQEDDKLFIEKETKLNELT 725
+CE+ + E I K + +N+ +++ K I++ F E +L L
Sbjct: 1112 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1171
Query: 726 NK---YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
++ E L+R+ + +LE + + T+ ++ ++ E + +RTEQ
Sbjct: 1172 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1231
Query: 783 XXXXXXXXXXXXXXXXX-TFGD----ENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
GD EN D+ +P+ + S K ++SV + V+QL++ L
Sbjct: 1232 DLHKAQQSLELIQSKIVKAAGDTTVIENSDV--SPETESSEKETMSVSLNQTVTQLQQLL 1289
Query: 838 LSCQQELDDLKERYKELD 855
+ Q+L KE Y+ L+
Sbjct: 1290 QAVNQQLTKEKEHYQVLE 1307
Score = 39.1 bits (87), Expect = 0.086
Identities = 77/380 (20%), Positives = 167/380 (43%), Gaps = 39/380 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+S++E LK+ + D+K++ AL+ + N+ LE + + S+++ E++NL
Sbjct: 818 KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ--ELQNL 875
Query: 121 TKDKE---------IKNLTDSLKTKSKKINELQEENDTLSNLIME----NVTESDNLN-- 165
K KE ++ L K + +LQEEN++L + E N+ E+ + +
Sbjct: 876 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 935
Query: 166 KEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
+E++ + K E ++ LE ++ E E+ + K Q EN + + + + +
Sbjct: 936 EELEIVLKEKENELKR---LEAMLKERESDLSSKTQLLQDVQDENKL------FKSQIEQ 986
Query: 226 L-NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEK 284
L ++ +++ + ++ + SE + ++ L + S+K+ +E H+ + ++
Sbjct: 987 LKQQNYQQASSFPPHEELLKVISERE---KEISGLWNELDSLKDAVE-HQRKKNNERQQQ 1042
Query: 285 LGENNEFETKAV--KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGT 342
+ E E E K V K+ ++ N + ++ KK+K+ + S V E
Sbjct: 1043 V-EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS-EEVKVLEHKL 1100
Query: 343 TSLDVFEILMDNIINKYQIDLDE---ILEKYTK-VQGDLNECTSELKSVNEKLASLNSQL 398
D L+ KY+ L E IL+K + V+ + N+ ++ ++ + + S
Sbjct: 1101 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1160
Query: 399 IEKENACNILRIQKERIHEI 418
E LR + + I +
Sbjct: 1161 TSSEQELERLRSENKDIENL 1180
>BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein.
Length = 1006
Score = 72.5 bits (170), Expect = 8e-12
Identities = 204/1028 (19%), Positives = 414/1028 (40%), Gaps = 97/1028 (9%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E + ++ + KL E ++K+ LE E Q + +++K+L E D+
Sbjct: 3 EVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATE---NKVKNLTEEMAALDE 59
Query: 125 EIKNLTDSLKT----KSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ LT K + + +LQ E D +S L + L ++V+DL+ + E +
Sbjct: 60 SVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL----RLEQQVEDLECSLEQEKK 115
Query: 181 KCIDLEKLVNESEN--KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT--S 236
+D E+ + E K+ +++ + K+ L + L D+ LS+L+ + D +
Sbjct: 116 LRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK-KKDSELSQLSLRVEDEQLLGA 174
Query: 237 TRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
KI EL A E+ +E E + + +E +L+E L E E A
Sbjct: 175 QMQKKI----KELQARAEELEEELEAERAARARVEKQRAEAARELEE-LSERLEEAGGAS 229
Query: 297 --------KVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
K +E+ R L E + +E+ + + R + A L + SL
Sbjct: 230 AGQREGCRKREAELGRLRRELEEAALRHEATVAA--LRRKQAEGAAELGEQ--VDSLQRV 285
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
++ ++ ++++D++ + ++ ++L+ ++ E +
Sbjct: 286 RQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADA 345
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
Q+ R+ S ++ + +KE + ++ + L L+ ++ R L+++ A +
Sbjct: 346 STQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLE-ELRRQLEEESKAKSALAHA 404
Query: 469 FDALITQYELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
AL +L R +E E E + L+ +KA EE K
Sbjct: 405 VQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKK 464
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
L L + + V+ NA K S E L++ ++E+ L L + T +
Sbjct: 465 LALRLQEAEEG-VEAANA-----KCSSLEKAKLRLQ-TESEDVTLELE----RATSAAAA 513
Query: 588 INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
++ K++ + ++L + +E+E Q ELE + + + G EL +++
Sbjct: 514 LD--KKQRHLERALEERRRQEEEMQR-ELEAAQRESRGLGTELFRLRHGHEEALEALETL 570
Query: 648 XXXXXXXXDEAKSLLEQ-NLALKEQCE-EKTRDC-----SRLEINIKTHEKTAEIQNRMI 700
+E L +Q +L+ K E EKT+ S ++ ++ E E++
Sbjct: 571 KRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKT 630
Query: 701 MRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV----NQLTTQK 756
+R+Q ++ + + E + KL E + L+R++ AV+ L++S +A N+ K
Sbjct: 631 LRIQLELSQ---VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLK 687
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
+EG + +LE + AT +E R E +
Sbjct: 688 KKMEGDLNDLELQLGH---ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQ 744
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL-DDECETCAEYLQERDEQCARL 875
+ +R S+++ +E+ +L+ L + ER + L + E E L Q L
Sbjct: 745 ALERRASLLA-AELEELRAAL--------EQGERSRRLAEQELLEATERLNLLHSQNTGL 795
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+K LE ++ L ++ R+A+ + A D A + + A +E+
Sbjct: 796 LNQKKKLEADLAQLSGEVEEAAQERREAE--EKAKKAITDAAMMAEELKKEQDTSAHLER 853
Query: 936 NKR-LMKTIEELRYKKQD-----LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
K+ L +T+ EL+ + ++ L+ ++QK K + + E +A++K+ + +
Sbjct: 854 MKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR 913
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
+ ++R KEL Q EE K L + ++VDKL ++ + ++Q E
Sbjct: 914 KHERRVKEL----------AYQAEEDRKNLARMQ---DLVDKLQSKVKSYKRQFEEAEQQ 960
Query: 1050 PVSNSTMY 1057
+N Y
Sbjct: 961 ANTNLAKY 968
Score = 65.7 bits (153), Expect = 9e-10
Identities = 85/423 (20%), Positives = 171/423 (40%), Gaps = 28/423 (6%)
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
L+++C E +D LE+ + EK + + L +++ D+ + LT +
Sbjct: 15 LEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDE-------SVARLTKE 67
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
+AL+ + A+ DL++ + V+ LT K +E ++ +LE + E+ +
Sbjct: 68 KKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKL 127
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV-ISDSEV--SQLKERLLSCQQEL 844
+ + L E K DS +S+ + D ++ +Q+++++ Q
Sbjct: 128 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 187
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
++L+E EL+ E A ++R E L E+LS + + + + +R+A+
Sbjct: 188 EELEE---ELEAERAARARVEKQRAEAAREL--EELSERLEEAGGASAGQREGCRKREAE 242
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAE-----VEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ +E + V AE E+ L + ++L +K +L+ V
Sbjct: 243 LGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD 302
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE---ECETCAEYLKQREEQC 1016
+ +E T+ E + ED +L E K + +EL + T L+ +
Sbjct: 303 LAANVETLTRAKASAEKLCRTYED---QLSEAKIKVEELQRQLADASTQRGRLQTESGEL 359
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
RL E K L + +LS K + +E L S A A+ + D+++E
Sbjct: 360 SRLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE 417
Query: 1077 NQK 1079
+
Sbjct: 418 QHE 420
Score = 46.0 bits (104), Expect = 8e-04
Identities = 129/707 (18%), Positives = 263/707 (37%), Gaps = 45/707 (6%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI---KS 114
K+C++ ++ +E +K+E+L +L D Q+ L+ + L + ++ L+SQ+ K+
Sbjct: 319 KLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKA 378
Query: 115 LEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDL--K 172
L ++L + + + L + K KS + +Q +L+ E E E+ L K
Sbjct: 379 LAAQSLEELR--RQLEEESKAKSALAHAVQALRHD-CDLLREQHEEEAEAQAELQRLLSK 435
Query: 173 KNNECLTQKC-IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN-TLSKLNRSI 230
N E + + + + E + K + + + E +++ + + +KL
Sbjct: 436 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 495
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
+ + + + + LD + + E+ E M +L+ E+
Sbjct: 496 ESEDVTLELERATSAAAALDKKQRHLERALEE-------RRRQEEEMQRELEAAQRESRG 548
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
T+ ++ + L +L + + E+K ++ I D + L + L+ +
Sbjct: 549 LGTELFRLRHGHEEALEAL--ETLKRENKNLQEEISDLTDQV--SLSGK-SIQELEKTKK 603
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
++ ++ Q L+E + EL V A ++ +L EK+ C LR
Sbjct: 604 ALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK---AEVDRKLAEKDEECANLRR 660
Query: 411 QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
+R E A + NE + K L+ L++ + Q A + T L
Sbjct: 661 NHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEA-QAATRLMQ 719
Query: 471 ALITQYELSRTDYEIEKEKLRLET-GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH 529
A + + + R E+++L E A+A+ LE+ +
Sbjct: 720 AQLKEEQAGRD----EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 775
Query: 530 EEL---TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTELV 585
+EL T+ +N LN K L ++ L + + ++ EK K +T+
Sbjct: 776 QELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAA 835
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
LK+E ++ L + + + E EL+ + +Q K + L
Sbjct: 836 MMAEELKKEQDTSAHL-ERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL 894
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
E K E ALK + R L + K ++ +LQ
Sbjct: 895 EAELDA-----EQKKHAE---ALK-GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQS 945
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
+++ + F E E + N KY + + D A + + + N+L
Sbjct: 946 KVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKL 992
Score = 45.6 bits (103), Expect = 0.001
Identities = 146/790 (18%), Positives = 300/790 (37%), Gaps = 71/790 (8%)
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSA 421
D+D++ K + + +++K++ E++A+L+ + L +K+ + E
Sbjct: 25 DIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVAR-------LTKEKKALQEAHQQ 77
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-----KITILFDALITQY 476
D+ +E+ + LTK L+L + D+ L+Q+ K + D +TQ
Sbjct: 78 ALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 136
Query: 477 ELSRT--DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT- 533
++ D + +EKL+ + + ++E + L EEL
Sbjct: 137 SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 196
Query: 534 -KLYKSKVDENNANL-NLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
+ +++V++ A ++ LSE ++ A A E + +L + L
Sbjct: 197 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEA-AL 255
Query: 592 KEENN--SLKSLNDVITREKETQASELERSCQVIKQNGFEL----DKMKADILMXXXXXX 645
+ E +L+ E Q L+R Q +++ EL D + A++
Sbjct: 256 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA 315
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
D+ + L+ Q + + RL+ + E + +I +L +
Sbjct: 316 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 375
Query: 706 ------QIQEDDKLFIEKETKLNE-LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
Q E+ + +E+E+K L + +AL+ D D + E EA +L
Sbjct: 376 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 435
Query: 759 VEGRIAE----LESDI--RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+A+ E+D RTE+ E L
Sbjct: 436 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 495
Query: 813 KLDDSP---KRSISVISDSEVSQ------LKERLLS---CQQELDDLKERYKELDDECET 860
+ +D +R+ S + + Q L+ER Q+EL+ + + L E
Sbjct: 496 ESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFR 555
Query: 861 CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-----------RTQQPVERQAKFADVA 909
+E E LK+E +L++++S+L +Q+ +T++ +E + A
Sbjct: 556 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 615
Query: 910 VNTDEDWANLHSVVVDRMSYD---AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEK 966
+ E L R+ + + E +++L + EE +++ + V +Q +++
Sbjct: 616 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA 675
Query: 967 YTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDE-ECETCAEYLKQREEQCKRLKEAKI 1024
T+ E +K++E +LE +L ++ E + T + +EEQ R +E ++
Sbjct: 676 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRL 735
Query: 1025 ALEIVDKLSNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKM 1083
A E L Q ALE++ L + + + S + Q++ + + L
Sbjct: 736 AAE----LHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 791
Query: 1084 NAKLITICKK 1093
N L+ KK
Sbjct: 792 NTGLLNQKKK 801
Score = 44.0 bits (99), Expect = 0.003
Identities = 121/659 (18%), Positives = 243/659 (36%), Gaps = 42/659 (6%)
Query: 478 LSRTDYEIEKEK--LRLET----GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
L R ++EKEK LR+E + + D L EA +V+ L +
Sbjct: 282 LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 341
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML-SLSEKDNKLTELVSTING 590
L + + L ++L EE + L +++ + SL E +L E +
Sbjct: 342 LADASTQRGRLQTESGELSRLL-EEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSA 400
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L +L+ D++ RE+ + +E + Q + L K A++
Sbjct: 401 LAHAVQALRHDCDLL-REQHEEEAEAQAELQRL------LSKANAEVAQWRSKYEADAIQ 453
Query: 651 XXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLE-----INIKTHEKTAEIQNRM--IMR 702
+EAK L L E+ E CS LE + ++ + T E++
Sbjct: 454 RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAA 513
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
L K+ + ++ E+ + E+ + EA +R+ +L R + + ++
Sbjct: 514 LDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRE 573
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP-KLDDSPKRS 821
L+ +I ++ T V + + E +L+++
Sbjct: 574 NKNLQEEI-SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLR 632
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
I + +++ +L +E +L+ ++ + + + + RLKK+
Sbjct: 633 IQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEG 692
Query: 882 ----LEQQVSNLKEQIRTQQPVER--QAKFADVAVNTDEDW---ANLH--SVVVDRMS-- 928
LE Q+ + Q Q R QA+ + DE+ A LH + ++R +
Sbjct: 693 DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 752
Query: 929 YDAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
AE+E+ + ++ E R +Q+L ++ + T + + +L E
Sbjct: 753 LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE 812
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV-ALEKQIESL 1046
+EE Q +E +E+ + E+ K+ ++ LE + K Q V L+ ++E
Sbjct: 813 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA 872
Query: 1047 SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENED 1105
+ V A V +++ + QK K + ++R K A + ED
Sbjct: 873 EQAALRGGKKQVQKLEAKV--RELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEED 929
Score = 35.9 bits (79), Expect = 0.80
Identities = 38/164 (23%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE- 990
E E N L +L + +LK + ++ + K K+ + E K K L + A L+E
Sbjct: 1 EGEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDES 60
Query: 991 ---LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLS 1047
L + K L E + L+ E++ L +AK+ LE ++ + + +LE++ +
Sbjct: 61 VARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLE--QQVEDLECSLEQEKKLRM 118
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQ----KLKKMNAKL 1087
+T + + G + + + D ++ Q KLKK +++L
Sbjct: 119 DTERAKRKL---EGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 159
>AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-1
protein.
Length = 795
Score = 72.5 bits (170), Expect = 8e-12
Identities = 131/614 (21%), Positives = 264/614 (42%), Gaps = 52/614 (8%)
Query: 69 EINLKLEKLSGEL-FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK 127
E+ ++ E E+ F +KE ++ Q E ++ Q+ L ++ K+ ++K
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE---KQVSLLLIQITEKENKMK 283
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
+LT L+ K+N+L+E+ S + +++ + +L KE++D+K + Q+ + +K
Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS----LQRSVSTQK 339
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
+ E + +I K IC + KE ++ ++ ++ S + T +C+L+
Sbjct: 340 AL-EEDLQIATKTICQLTEEKETQME------ESNKARAAHSFVVTEFET---TVCSLE- 388
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
EL + E ED I +EL + + ++ KL N E E + +K + K L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILT-MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL- 446
Query: 308 SLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL 367
L E N + +K + + + L+ +L A + EI + I Q E+
Sbjct: 447 -LYE---NKQFEKIAEELKGTEQELIGLLQAR--EKEVHDLEIQLTAITTSEQYYSKEVK 500
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSAVTIDI 426
+ T+++ + + T EL S KL+ N +L ++ + + L+ Q+E I+ + +
Sbjct: 501 DLKTELENEKLKNT-ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERM 558
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ L+E T+ +L ++ ++ + D+ K + L Q E ++ Y
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVE-NKNKY--- 614
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
E+L+ E K + LE K E+T Y+ ++++ +
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 547 LNLIKILSEEIDALKIAIAKNEEKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDV 604
+ L EE++ K+ IA K+ +K +K+ E+V+ + K + + + D
Sbjct: 675 ---EENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
Query: 605 ---ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ + KE + S L S ++ EL +KA++L EAK
Sbjct: 731 ELGLYKSKEQEQSSLRASLEI------ELSNLKAELLSVKKQLEIEREEKEKLKREAK-- 782
Query: 662 LEQNLALKEQCEEK 675
E LKE+ ++K
Sbjct: 783 -ENTATLKEKKKKK 795
Score = 56.8 bits (131), Expect = 4e-07
Identities = 109/536 (20%), Positives = 221/536 (41%), Gaps = 56/536 (10%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLS 575
L+E + +++ L +E K K E +L LI+I +E + L + ++ +K+ L
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDK--EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDV---ITREKETQASELERSCQVIKQNGFELDK 632
EK +E + ++++++ K L D+ + R TQ + LE Q+ + +L +
Sbjct: 301 EKTKLQSENLK--QSIEKQHHLTKELEDIKVSLQRSVSTQKA-LEEDLQIATKTICQLTE 357
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
K + + LE+ L ++Q EK D +L+I T
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED--QLKI------LT 409
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E+Q + +++E KL KE +L EL K K K E E +
Sbjct: 410 MELQKK-----SSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKG- 462
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T+++L+ G + E ++ + + E +DL
Sbjct: 463 -TEQELI-GLLQAREKEVHDLEIQLTAITTSEQY--------------YSKEVKDL--KT 504
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L++ ++ + S L+ + L+ QE D+ K ++ + + +Q
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELT--QETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
L++ + L ++ ++E+++ Q+ E + K ++E+ NL V ++ Y E
Sbjct: 563 ENLQETETQLRNELEYVREELK-QKRDEVKCKLD----KSEENCNNLRKQVENKNKYIEE 617
Query: 933 VEK-NKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAEL 988
+++ NK L K T E + ++K V K++ +E +K E + +KE+ED K
Sbjct: 618 LQQENKALKKKGTAESKQLNVYEIK--VNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
E L + ++ + + K+ +++C+ +AL K K+ E+ E
Sbjct: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSE 731
Score = 50.8 bits (116), Expect = 3e-05
Identities = 61/268 (22%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
++++ + ++ L++ +++ +L+++ + +E L++ E+ L KE LE +
Sbjct: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE---LEDIKVS 330
Query: 889 LKEQIRTQQPVERQAKFADVAVN--TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + TQ+ +E + A + T+E + R ++ V + + + ++EEL
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 947 -RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
R ++Q L+ +++ + KK E E K + + ELEELK K L E+ ET
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK---KVLGEK-ETL 446
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
KQ E+ + LK + E++ L A EK++ L + T S
Sbjct: 447 LYENKQFEKIAEELKGTE--QELIGLLQ----AREKEVHDL------EIQLTAITTSEQY 494
Query: 1066 QNQQITDVMKENQKLKKMNAKLITICKK 1093
++++ D+ E + K N +L + C K
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNK 522
Score = 47.2 bits (107), Expect = 3e-04
Identities = 124/576 (21%), Positives = 250/576 (43%), Gaps = 60/576 (10%)
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+SK+ EN KI+ + A++ NE+ L L E + +L+ +ENN
Sbjct: 131 ESKLQENR------KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI-------KENN 177
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + L +++ KET A RS + K+ +E ++ + +
Sbjct: 178 ATRHLCNLL---KETCA----RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
Query: 657 EAK-SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+A+ S LE + LKE EK + + E + ++K ++ +I +K+ + D F+
Sbjct: 231 QAENSRLEMHFKLKED-YEKIQHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 716 --EKETKLNELTNK----YEALKRDYDA---AVKDLESSREAVNQ-LTTQKDLVEG-RIA 764
E K+N+L K E LK+ + K+LE + ++ + ++TQK L E +IA
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD--DSPKRSI 822
TE+ T E E +L+ + + +
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 823 SVISDSEVSQLKE--RLLSCQQ-ELDDLKERYKELD------DECETCAEYLQERDEQCA 873
++ + S+L+E +L + ++ EL++LK+ E + + E AE L+ +++
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L + + E++V +L+ Q+ E+ + T+ + L + + +
Sbjct: 469 GLLQAR---EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 934 EKNKRLMKTIE---ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELE 989
E + +T + EL+ +++D+ N K ++ M K + +E E + R ELE + EL+
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNN-KKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 990 ELKQRYK-ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + K +LD+ E C KQ E + K ++E L+ +K +K E + L+
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAES--KQLNV 638
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ + + + SA + +ITD ++ + KK++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Score = 44.8 bits (101), Expect = 0.002
Identities = 98/533 (18%), Positives = 203/533 (38%), Gaps = 45/533 (8%)
Query: 270 LELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
L+ +++ L+E + EN + +K + + N L E + K K +R +
Sbjct: 151 LQFGNEKVSLKLEEGIQENKDL----IKENNATRHLCNLLKETCARSAEKTKKYEYER-E 205
Query: 330 DSLLAVLDAEFGTTSL-DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
++ +D + FE L N ++ E Y K+Q E E+
Sbjct: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
Query: 389 EKLASLNSQLIEKENACN----ILRIQKERIHEISSAVTI--DIVKKENELKEILTKECL 442
++++ L Q+ EKEN +L +++++++ + + +K+ E + LTKE
Sbjct: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE-- 323
Query: 443 KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXX 502
L +K+ + R + + + I + E T E + +
Sbjct: 324 -LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
Query: 503 XXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
LE+ +++K L EL K S+++E N ++ E++ LK
Sbjct: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKK-SSELEEMTKLTNNKEV---ELEELKK 438
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV 622
+ + E +L ++ + ++ + G ++E L + + E Q + + S Q
Sbjct: 439 VLGEKE----TLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 623 IKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
+ +L +++ + L + + + L LK Q E+ + +
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 682 LEINIKTHEKTAEIQNRMIMRLQ------KQIQEDDKLFIEK-ETKLNELT------NKY 728
E +K E E + ++ L+ KQ +++ K ++K E N L NKY
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 729 --------EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
+ALK+ A K L VN+L + + + + E+ + E
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
Score = 39.5 bits (88), Expect = 0.065
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 24/274 (8%)
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
V +++E+ Q + +L ++ ++ ++ +EL E + L+E ++ L KE +
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLM 940
+ LKE + E+ K+ T + + +L++ + ++ E+ +N RL
Sbjct: 181 HLCNLLKETCA--RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRL- 237
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
E+ +K LK K+Q ++Y K E K K++ ++ E + + K+L
Sbjct: 238 ----EMHFK---LKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 1001 ECETCAEYLKQREEQCKRLKE-AKIALE----IVDKLSNQKVALEKQIESLSNTPVSNST 1055
E + + Q EE+ K E K ++E + +L + KV+L++ S+S
Sbjct: 288 LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR---SVSTQKALEED 344
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ +AT + ++ M+E+ K + ++ ++T
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Score = 39.5 bits (88), Expect = 0.065
Identities = 65/272 (23%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTRDLL---MSQIKSLE 116
+ L + ++++ L+L+ ++ + K+Q+ + + +NL ETQ R+ L ++K
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 117 ME---NLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK---EVD 169
E L K +E NL ++ K+K I ELQ+EN L + ES LN +V+
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK---KGTAESKQLNVYEIKVN 644
Query: 170 DLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-L 226
L+ E QK ++ + + KI +N+ + + K +I + + K
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIADEAVKLQKEIDKRC 703
Query: 227 NRSISD-----SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD- 280
I++ +Y+KI + + + G KE ++ +S++ LE+ N+ +
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIE-ERDSELGLYKSKE--QEQSSLRASLEIELSNLKAEL 760
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
L K E E K K+ E K N +L E+
Sbjct: 761 LSVKKQLEIEREEKE-KLKREAKENTATLKEK 791
>BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 71.7 bits (168), Expect = 1e-11
Identities = 143/710 (20%), Positives = 295/710 (41%), Gaps = 71/710 (10%)
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
DN I Q L E+L + ++ D+ S+L S + + S ++KE A ++K
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA-----LRK 202
Query: 413 ERIHEISS-AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
+ +I+ +V++EN+ ++ + +++ D+ + QD + + +
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
Query: 472 LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
++ ++E + ++L L T + + TL +K L E
Sbjct: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK-------QTLNARDESIKKLLEM 315
Query: 532 L-TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTELVSTIN 589
L +K +K E + + ++ E+ + E +L EK+N L E +
Sbjct: 316 LQSKGLSAKATEED-HERTRRLAEAEMHVHHL------ESLLEQKEKENSMLREEMHRRF 368
Query: 590 GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
++ K+L VI K+++ S +ER + +++ E+ +K++ +
Sbjct: 369 ENAPDSAKTKALQTVI-EMKDSKISSMERGLRDLEE---EIQMLKSNGALSTEEREEEMK 424
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+K + + LKE+ K L+ +K A +Q I ++++++
Sbjct: 425 QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK------KKAAGLQAE-IGQVKQELSR 477
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D + +TKL LTN++ K+ + + L + + L T+ D + R+ E E+
Sbjct: 478 KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET- 536
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + T E DL + + D +R ++V+ +
Sbjct: 537 MLNKKTKQI-------------QDMAEEKGTQAGEIHDLKD---MLDVKERKVNVL-QKK 579
Query: 830 VSQLKERLLSCQQELDDLKERYKEL-------DDECETCAEYLQERDEQCARLK----KE 878
+ L+E+L ++++ LKER K L D T E L E++ RLK ++
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 639
Query: 879 KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+ ++++ N K+ ++ + + K + + + E A+L + S + K
Sbjct: 640 EREKQEEIDNYKKDLK-----DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 939 LMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+KT+E L KK++ ++++KA E + E + ++ + E+ K +
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR-IQHLEREITRYKDESSK 753
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
E + E LK+ E + K K+ KIA LE K N+KVA K E +
Sbjct: 754 AQAEVDRLLEILKEVENE-KNDKDKKIAELERQVKDQNKKVANLKHKEQV 802
Score = 68.9 bits (161), Expect = 9e-11
Identities = 89/506 (17%), Positives = 205/506 (40%), Gaps = 27/506 (5%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 623 IKQNGF-----ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR 677
+N EL +A E + LAL+ + E T
Sbjct: 435 FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
Query: 678 DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDA 737
S + +I+ +++ + + LQ ++ EKET LN+ T + + + +
Sbjct: 495 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 554
Query: 738 AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXX 797
++ ++ ++ + ++++ +I L+ +R ++
Sbjct: 555 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614
Query: 798 XXT----FGDENRD---LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
T ++ R L E D+ K+ ++ LKE++ Q +L + +
Sbjct: 615 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 674
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
+L + + A ++D +RLK +++LEQ+ + + A A +
Sbjct: 675 LLDLKEHASSLASSGLKKD---SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 731
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ +L + ++ + RL++ ++E+ +K D + ++++ ++ K
Sbjct: 732 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 791
Query: 970 KDKEFEAKRK-ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA-----K 1023
K + K + E + LEE ++R L++ + + L++++++ + L+EA +
Sbjct: 792 KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 851
Query: 1024 IALE---IVDKLSNQKVALEKQIESL 1046
I E ++ + + + EKQ+E L
Sbjct: 852 ITAEREMVLAQEESARTNAEKQVEEL 877
Score = 66.5 bits (155), Expect = 5e-10
Identities = 121/611 (19%), Positives = 243/611 (39%), Gaps = 39/611 (6%)
Query: 70 INLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNL 129
I +K K+S +++ + ++ N L T+ R+ M Q++ + +++ L
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQL 443
Query: 130 TDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLV 189
+ L +K + EL+++ L I + E + E+ L+ E LT + D ++ +
Sbjct: 444 KEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 503
Query: 190 NESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
+ + K + + + + +L + + + LN+ T+ + +
Sbjct: 504 EVLKESLTAKE--QRAAILQTEVDALRLRLEEKETMLNKK-------TKQIQDMAEEKGT 554
Query: 250 DAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
AG + +K+ L++ E + + L +K+ E K MS +K + SL
Sbjct: 555 QAG---------EIHDLKDMLDVKERKVNV-LQKKIENLQEQLRDKEKQMSSLKERVKSL 604
Query: 310 SEQLINNESKKSK-DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
N ++ + + K+ + L + D E I+ Y+ DL ++ E
Sbjct: 605 QADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDRDEREKQEEIDNYKKDLKDLKE 659
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
K + +QGDL+E + L + E +SL S ++K++ L I E+ E + + K
Sbjct: 660 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 719
Query: 429 KENELKEILTKECL--KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
E + ++ L+ +I R D+ A ++ L + ++ + E + D + +
Sbjct: 720 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE-ILKEVENEKNDKDKK 778
Query: 487 KEKL-RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS--KVDEN 543
+L R K V LEEA +L++ +L S K D+
Sbjct: 779 IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR 838
Query: 544 NANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK---S 600
L S +I A + + EE + +EK ++ EL+ + +K+E S+K S
Sbjct: 839 IEELEEALRESVQITAEREMVLAQEESARTNAEK--QVEELLMAMEKVKQELESMKAKLS 896
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
EKET + L +++ E+ +MK + L+ K
Sbjct: 897 STQQSLAEKETHLTNLRAE---RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK 953
Query: 661 LLEQNLALKEQ 671
E+ ALK +
Sbjct: 954 TQEEVAALKRE 964
Score = 65.3 bits (152), Expect = 1e-09
Identities = 109/548 (19%), Positives = 228/548 (41%), Gaps = 49/548 (8%)
Query: 39 ETQSNPIKLQDSGTITISCKMCQSLKESSNEI---NLKLEKLSGELFDIKEQ----KSAL 91
E Q +K + +G ++ Q L E+ KLE L+ + D K+ K +L
Sbjct: 451 EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 510
Query: 92 EGKYQNL-ILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL 150
K Q IL+T+ D L +++ E K K+I+++ + T++ +I++L++ D
Sbjct: 511 TAKEQRAAILQTEV-DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
Query: 151 SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKEN 210
+ + +NL +++ D +K L ++ L+ ++ A L+E
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT--------ALTTLEEA 621
Query: 211 LIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
L + + T+ +L D + + Q E+D ++D K+L E + ++ L
Sbjct: 622 LAEK-----ERTIERLKEQ-RDRDEREK-------QEEIDNYKKDLKDLKEKVSLLQGDL 668
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E ++ +DL E K + ++ L E+ + ES+ K H
Sbjct: 669 SEKEASL-LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH------ 721
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
A L+A D + L + I +Y+ + + + ++ L E +E ++K
Sbjct: 722 --EAALEARASPEMSDRIQHL-EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID 450
+A L Q+ ++ L+ KE++ + SA ++ ++ + +++ + K D
Sbjct: 779 IAELERQVKDQNKKVANLK-HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
Query: 451 IPRDLDQDLPAHKKITILFDALITQYELSRTDYE--IEK-----EKLRLETGTAKAVXXX 503
+L++ L +IT + ++ Q E +RT+ E +E+ EK++ E + KA
Sbjct: 838 RIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS 897
Query: 504 XXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
L E ++ + E + + + E +AN+ L+++ S + +
Sbjct: 898 TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 957
Query: 563 AIAKNEEK 570
A EK
Sbjct: 958 VAALKREK 965
Score = 54.0 bits (124), Expect = 3e-06
Identities = 55/237 (23%), Positives = 101/237 (42%), Gaps = 13/237 (5%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
RS S ++V QLKE L S + + ++LK++ L E + L +D + L+ +
Sbjct: 430 RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL 489
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
+L Q S+ K+ I + + + T+ D L + M +K K++
Sbjct: 490 ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN----KKTKQI 545
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL- 998
EE + ++ + + K K+ E +++L D + ++ LK+R K L
Sbjct: 546 QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
Query: 999 ------DEECETCAEYLKQREEQCKRLKEA--KIALEIVDKLSNQKVALEKQIESLS 1047
D T E L ++E +RLKE + E +++ N K L+ E +S
Sbjct: 606 ADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
Score = 53.6 bits (123), Expect = 4e-06
Identities = 122/609 (20%), Positives = 252/609 (41%), Gaps = 59/609 (9%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
I+ N + QDS + T + + +E+ ++ + E+ + ELF +++ +E
Sbjct: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEME----- 292
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN 157
L +ETQ + L +D+ IK L + L++K +E+++ L E
Sbjct: 293 LRIETQKQTL------------NARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEA 339
Query: 158 VTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHI 217
+L ++ +K N L + ++ + + + K + ++K++ I S+
Sbjct: 340 EMHVHHLESLLEQKEKENSMLRE---EMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 218 GYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
G + ++ S+ ST + +++ R K + +K L E
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEERE--EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESKKSKDHIDRYKDSLLAV 335
+L +K + + +S L +L +L + N+ SK HI+ K+SL A
Sbjct: 455 E-ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 513
Query: 336 LD-AEFGTTSLDVFEILM---DNIINKYQIDLDEILEKYTKVQGDLNECTSEL----KSV 387
A T +D + + + ++NK + ++ E+ G++++ L + V
Sbjct: 514 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
Query: 388 N---EKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
N +K+ +L QL +KE + L KER+ + A T + L+E L ++ +
Sbjct: 574 NVLQKKIENLQEQLRDKEKQMSSL---KERVKSL-QADTTNTDTALTTLEEALAEKERTI 629
Query: 445 SKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT-AKAV 500
+LK RD +++ +KK L D L + L + D EKE L+ A ++
Sbjct: 630 ERLKEQRDRDEREKQEEIDNYKK--DLKD-LKEKVSLLQGDLS-EKEASLLDLKEHASSL 685
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA--NLNLIKILSEEID 558
LE+ E + +L K +++ ++ + + I+ L EI
Sbjct: 686 ASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745
Query: 559 ALKIAIAKNE---EKMLSL-----SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE 610
K +K + +++L + +EK++K ++ +K++N + +L EK+
Sbjct: 746 RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK 805
Query: 611 TQASELERS 619
A LE +
Sbjct: 806 KSAQMLEEA 814
Score = 44.8 bits (101), Expect = 0.002
Identities = 61/284 (21%), Positives = 122/284 (42%), Gaps = 14/284 (4%)
Query: 57 CKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR-DLLMSQIKSL 115
C +S + ++E L+ + S E+ D + +Y++ + Q D L+ +K +
Sbjct: 710 CLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 768
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKEVDDL 171
E E KDK+I L +K ++KK+ L Q E + ++ E DNLN L
Sbjct: 769 ENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 828
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKN-ICAQCKLK----ENLIQSLHIGYDNTLSKL 226
+ + + +LE+ + ES + + AQ + E ++ L + + +L
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 888
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
S+ +ST+ + + ++ L R + ++ E+ +K L + D + L
Sbjct: 889 E-SMKAKLSSTQQS-LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDANIALL 945
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E + + K + ++ +KR + L +QL + K D Y+D
Sbjct: 946 ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 989
>BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 71.7 bits (168), Expect = 1e-11
Identities = 143/710 (20%), Positives = 295/710 (41%), Gaps = 71/710 (10%)
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
DN I Q L E+L + ++ D+ S+L S + + S ++KE A ++K
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA-----LRK 202
Query: 413 ERIHEISS-AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
+ +I+ +V++EN+ ++ + +++ D+ + QD + + +
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
Query: 472 LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
++ ++E + ++L L T + + TL +K L E
Sbjct: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK-------QTLNARDESIKKLLEM 315
Query: 532 L-TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTELVSTIN 589
L +K +K E + + ++ E+ + E +L EK+N L E +
Sbjct: 316 LQSKGLSAKATEED-HERTRRLAEAEMHVHHL------ESLLEQKEKENSMLREEMHRRF 368
Query: 590 GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
++ K+L VI K+++ S +ER + +++ E+ +K++ +
Sbjct: 369 ENAPDSAKTKALQTVI-EMKDSKISSMERGLRDLEE---EIQMLKSNGALSTEEREEEMK 424
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+K + + LKE+ K L+ +K A +Q I ++++++
Sbjct: 425 QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK------KKAAGLQAE-IGQVKQELSR 477
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D + +TKL LTN++ K+ + + L + + L T+ D + R+ E E+
Sbjct: 478 KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET- 536
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + T E DL + + D +R ++V+ +
Sbjct: 537 MLNKKTKQI-------------QDMAEEKGTQAGEIHDLKD---MLDVKERKVNVL-QKK 579
Query: 830 VSQLKERLLSCQQELDDLKERYKEL-------DDECETCAEYLQERDEQCARLK----KE 878
+ L+E+L ++++ LKER K L D T E L E++ RLK ++
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 639
Query: 879 KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+ ++++ N K+ ++ + + K + + + E A+L + S + K
Sbjct: 640 EREKQEEIDNYKKDLK-----DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 939 LMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+KT+E L KK++ ++++KA E + E + ++ + E+ K +
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR-IQHLEREITRYKDESSK 753
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
E + E LK+ E + K K+ KIA LE K N+KVA K E +
Sbjct: 754 AQAEVDRLLEILKEVENE-KNDKDKKIAELERQVKDQNKKVANLKHKEQV 802
Score = 68.9 bits (161), Expect = 9e-11
Identities = 89/506 (17%), Positives = 205/506 (40%), Gaps = 27/506 (5%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 623 IKQNGF-----ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR 677
+N EL +A E + LAL+ + E T
Sbjct: 435 FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
Query: 678 DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDA 737
S + +I+ +++ + + LQ ++ EKET LN+ T + + + +
Sbjct: 495 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 554
Query: 738 AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXX 797
++ ++ ++ + ++++ +I L+ +R ++
Sbjct: 555 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614
Query: 798 XXT----FGDENRD---LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
T ++ R L E D+ K+ ++ LKE++ Q +L + +
Sbjct: 615 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 674
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
+L + + A ++D +RLK +++LEQ+ + + A A +
Sbjct: 675 LLDLKEHASSLASSGLKKD---SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 731
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ +L + ++ + RL++ ++E+ +K D + ++++ ++ K
Sbjct: 732 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 791
Query: 970 KDKEFEAKRK-ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA-----K 1023
K + K + E + LEE ++R L++ + + L++++++ + L+EA +
Sbjct: 792 KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 851
Query: 1024 IALE---IVDKLSNQKVALEKQIESL 1046
I E ++ + + + EKQ+E L
Sbjct: 852 ITAEREMVLAQEESARTNAEKQVEEL 877
Score = 66.5 bits (155), Expect = 5e-10
Identities = 121/611 (19%), Positives = 243/611 (39%), Gaps = 39/611 (6%)
Query: 70 INLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNL 129
I +K K+S +++ + ++ N L T+ R+ M Q++ + +++ L
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQL 443
Query: 130 TDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLV 189
+ L +K + EL+++ L I + E + E+ L+ E LT + D ++ +
Sbjct: 444 KEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 503
Query: 190 NESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
+ + K + + + + +L + + + LN+ T+ + +
Sbjct: 504 EVLKESLTAKE--QRAAILQTEVDALRLRLEEKETMLNKK-------TKQIQDMAEEKGT 554
Query: 250 DAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
AG + +K+ L++ E + + L +K+ E K MS +K + SL
Sbjct: 555 QAG---------EIHDLKDMLDVKERKVNV-LQKKIENLQEQLRDKEKQMSSLKERVKSL 604
Query: 310 SEQLINNESKKSK-DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
N ++ + + K+ + L + D E I+ Y+ DL ++ E
Sbjct: 605 QADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDRDEREKQEEIDNYKKDLKDLKE 659
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
K + +QGDL+E + L + E +SL S ++K++ L I E+ E + + K
Sbjct: 660 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 719
Query: 429 KENELKEILTKECL--KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
E + ++ L+ +I R D+ A ++ L + ++ + E + D + +
Sbjct: 720 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE-ILKEVENEKNDKDKK 778
Query: 487 KEKL-RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS--KVDEN 543
+L R K V LEEA +L++ +L S K D+
Sbjct: 779 IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR 838
Query: 544 NANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK---S 600
L S +I A + + EE + +EK ++ EL+ + +K+E S+K S
Sbjct: 839 IEELEEALRESVQITAEREMVLAQEESARTNAEK--QVEELLMAMEKVKQELESMKAKLS 896
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
EKET + L +++ E+ +MK + L+ K
Sbjct: 897 STQQSLAEKETHLTNLRAE---RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK 953
Query: 661 LLEQNLALKEQ 671
E+ ALK +
Sbjct: 954 TQEEVAALKRE 964
Score = 65.3 bits (152), Expect = 1e-09
Identities = 109/548 (19%), Positives = 228/548 (41%), Gaps = 49/548 (8%)
Query: 39 ETQSNPIKLQDSGTITISCKMCQSLKESSNEI---NLKLEKLSGELFDIKEQ----KSAL 91
E Q +K + +G ++ Q L E+ KLE L+ + D K+ K +L
Sbjct: 451 EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 510
Query: 92 EGKYQNL-ILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL 150
K Q IL+T+ D L +++ E K K+I+++ + T++ +I++L++ D
Sbjct: 511 TAKEQRAAILQTEV-DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
Query: 151 SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKEN 210
+ + +NL +++ D +K L ++ L+ ++ A L+E
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT--------ALTTLEEA 621
Query: 211 LIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
L + + T+ +L D + + Q E+D ++D K+L E + ++ L
Sbjct: 622 LAEK-----ERTIERLKEQ-RDRDEREK-------QEEIDNYKKDLKDLKEKVSLLQGDL 668
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E ++ +DL E K + ++ L E+ + ES+ K H
Sbjct: 669 SEKEASL-LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH------ 721
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
A L+A D + L + I +Y+ + + + ++ L E +E ++K
Sbjct: 722 --EAALEARASPEMSDRIQHL-EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID 450
+A L Q+ ++ L+ KE++ + SA ++ ++ + +++ + K D
Sbjct: 779 IAELERQVKDQNKKVANLK-HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
Query: 451 IPRDLDQDLPAHKKITILFDALITQYELSRTDYE--IEK-----EKLRLETGTAKAVXXX 503
+L++ L +IT + ++ Q E +RT+ E +E+ EK++ E + KA
Sbjct: 838 RIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS 897
Query: 504 XXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
L E ++ + E + + + E +AN+ L+++ S + +
Sbjct: 898 TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 957
Query: 563 AIAKNEEK 570
A EK
Sbjct: 958 VAALKREK 965
Score = 54.0 bits (124), Expect = 3e-06
Identities = 55/237 (23%), Positives = 101/237 (42%), Gaps = 13/237 (5%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
RS S ++V QLKE L S + + ++LK++ L E + L +D + L+ +
Sbjct: 430 RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL 489
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
+L Q S+ K+ I + + + T+ D L + M +K K++
Sbjct: 490 ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN----KKTKQI 545
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL- 998
EE + ++ + + K K+ E +++L D + ++ LK+R K L
Sbjct: 546 QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
Query: 999 ------DEECETCAEYLKQREEQCKRLKEA--KIALEIVDKLSNQKVALEKQIESLS 1047
D T E L ++E +RLKE + E +++ N K L+ E +S
Sbjct: 606 ADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
Score = 53.6 bits (123), Expect = 4e-06
Identities = 122/609 (20%), Positives = 252/609 (41%), Gaps = 59/609 (9%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
I+ N + QDS + T + + +E+ ++ + E+ + ELF +++ +E
Sbjct: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEME----- 292
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN 157
L +ETQ + L +D+ IK L + L++K +E+++ L E
Sbjct: 293 LRIETQKQTL------------NARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEA 339
Query: 158 VTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHI 217
+L ++ +K N L + ++ + + + K + ++K++ I S+
Sbjct: 340 EMHVHHLESLLEQKEKENSMLRE---EMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 218 GYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
G + ++ S+ ST + +++ R K + +K L E
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEERE--EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESKKSKDHIDRYKDSLLAV 335
+L +K + + +S L +L +L + N+ SK HI+ K+SL A
Sbjct: 455 E-ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 513
Query: 336 LD-AEFGTTSLDVFEILM---DNIINKYQIDLDEILEKYTKVQGDLNECTSEL----KSV 387
A T +D + + + ++NK + ++ E+ G++++ L + V
Sbjct: 514 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
Query: 388 N---EKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
N +K+ +L QL +KE + L KER+ + A T + L+E L ++ +
Sbjct: 574 NVLQKKIENLQEQLRDKEKQMSSL---KERVKSL-QADTTNTDTALTTLEEALAEKERTI 629
Query: 445 SKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT-AKAV 500
+LK RD +++ +KK L D L + L + D EKE L+ A ++
Sbjct: 630 ERLKEQRDRDEREKQEEIDNYKK--DLKD-LKEKVSLLQGDLS-EKEASLLDLKEHASSL 685
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA--NLNLIKILSEEID 558
LE+ E + +L K +++ ++ + + I+ L EI
Sbjct: 686 ASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745
Query: 559 ALKIAIAKNE---EKMLSL-----SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE 610
K +K + +++L + +EK++K ++ +K++N + +L EK+
Sbjct: 746 RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK 805
Query: 611 TQASELERS 619
A LE +
Sbjct: 806 KSAQMLEEA 814
Score = 44.8 bits (101), Expect = 0.002
Identities = 61/284 (21%), Positives = 122/284 (42%), Gaps = 14/284 (4%)
Query: 57 CKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR-DLLMSQIKSL 115
C +S + ++E L+ + S E+ D + +Y++ + Q D L+ +K +
Sbjct: 710 CLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 768
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKEVDDL 171
E E KDK+I L +K ++KK+ L Q E + ++ E DNLN L
Sbjct: 769 ENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 828
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKN-ICAQCKLK----ENLIQSLHIGYDNTLSKL 226
+ + + +LE+ + ES + + AQ + E ++ L + + +L
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 888
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
S+ +ST+ + + ++ L R + ++ E+ +K L + D + L
Sbjct: 889 E-SMKAKLSSTQQS-LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDANIALL 945
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E + + K + ++ +KR + L +QL + K D Y+D
Sbjct: 946 ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 989
>AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein.
Length = 1116
Score = 71.7 bits (168), Expect = 1e-11
Identities = 143/710 (20%), Positives = 295/710 (41%), Gaps = 71/710 (10%)
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
DN I Q L E+L + ++ D+ S+L S + + S ++KE A ++K
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA-----LRK 202
Query: 413 ERIHEISS-AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDA 471
+ +I+ +V++EN+ ++ + +++ D+ + QD + + +
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
Query: 472 LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
++ ++E + ++L L T + + TL +K L E
Sbjct: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK-------QTLNARDESIKKLLEM 315
Query: 532 L-TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTELVSTIN 589
L +K +K E + + ++ E+ + E +L EK+N L E +
Sbjct: 316 LQSKGLSAKATEED-HERTRRLAEAEMHVHHL------ESLLEQKEKENSMLREEMHRRF 368
Query: 590 GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
++ K+L VI K+++ S +ER + +++ E+ +K++ +
Sbjct: 369 ENAPDSAKTKALQTVI-EMKDSKISSMERGLRDLEE---EIQMLKSNGALSTEEREEEMK 424
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+K + + LKE+ K L+ +K A +Q I ++++++
Sbjct: 425 QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK------KKAAGLQAE-IGQVKQELSR 477
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D + +TKL LTN++ K+ + + L + + L T+ D + R+ E E+
Sbjct: 478 KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET- 536
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ ++T + T E DL + + D +R ++V+ +
Sbjct: 537 MLNKKTKQI-------------QDMAEEKGTQAGEIHDLKD---MLDVKERKVNVL-QKK 579
Query: 830 VSQLKERLLSCQQELDDLKERYKEL-------DDECETCAEYLQERDEQCARLK----KE 878
+ L+E+L ++++ LKER K L D T E L E++ RLK ++
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 639
Query: 879 KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+ ++++ N K+ ++ + + K + + + E A+L + S + K
Sbjct: 640 EREKQEEIDNYKKDLK-----DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 939 LMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+KT+E L KK++ ++++KA E + E + ++ + E+ K +
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR-IQHLEREITRYKDESSK 753
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESL 1046
E + E LK+ E + K K+ KIA LE K N+KVA K E +
Sbjct: 754 AQAEVDRLLEILKEVENE-KNDKDKKIAELERQVKDQNKKVANLKHKEQV 802
Score = 68.9 bits (161), Expect = 9e-11
Identities = 89/506 (17%), Positives = 205/506 (40%), Gaps = 27/506 (5%)
Query: 565 AKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELE--RSCQV 622
AK + + KD+K++ + + L+EE LKS + T E+E + ++E RS
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
Query: 623 IKQNGF-----ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR 677
+N EL +A E + LAL+ + E T
Sbjct: 435 FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
Query: 678 DCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDA 737
S + +I+ +++ + + LQ ++ EKET LN+ T + + + +
Sbjct: 495 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 554
Query: 738 AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXX 797
++ ++ ++ + ++++ +I L+ +R ++
Sbjct: 555 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614
Query: 798 XXT----FGDENRD---LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
T ++ R L E D+ K+ ++ LKE++ Q +L + +
Sbjct: 615 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 674
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
+L + + A ++D +RLK +++LEQ+ + + A A +
Sbjct: 675 LLDLKEHASSLASSGLKKD---SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 731
Query: 911 NTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ +L + ++ + RL++ ++E+ +K D + ++++ ++ K
Sbjct: 732 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 791
Query: 970 KDKEFEAKRK-ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA-----K 1023
K + K + E + LEE ++R L++ + + L++++++ + L+EA +
Sbjct: 792 KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 851
Query: 1024 IALE---IVDKLSNQKVALEKQIESL 1046
I E ++ + + + EKQ+E L
Sbjct: 852 ITAEREMVLAQEESARTNAEKQVEEL 877
Score = 66.5 bits (155), Expect = 5e-10
Identities = 121/611 (19%), Positives = 243/611 (39%), Gaps = 39/611 (6%)
Query: 70 INLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNL 129
I +K K+S +++ + ++ N L T+ R+ M Q++ + +++ L
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQL 443
Query: 130 TDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLV 189
+ L +K + EL+++ L I + E + E+ L+ E LT + D ++ +
Sbjct: 444 KEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 503
Query: 190 NESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSEL 249
+ + K + + + + +L + + + LN+ T+ + +
Sbjct: 504 EVLKESLTAKE--QRAAILQTEVDALRLRLEEKETMLNKK-------TKQIQDMAEEKGT 554
Query: 250 DAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
AG + +K+ L++ E + + L +K+ E K MS +K + SL
Sbjct: 555 QAG---------EIHDLKDMLDVKERKVNV-LQKKIENLQEQLRDKEKQMSSLKERVKSL 604
Query: 310 SEQLINNESKKSK-DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILE 368
N ++ + + K+ + L + D E I+ Y+ DL ++ E
Sbjct: 605 QADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDRDEREKQEEIDNYKKDLKDLKE 659
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
K + +QGDL+E + L + E +SL S ++K++ L I E+ E + + K
Sbjct: 660 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 719
Query: 429 KENELKEILTKECL--KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
E + ++ L+ +I R D+ A ++ L + ++ + E + D + +
Sbjct: 720 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE-ILKEVENEKNDKDKK 778
Query: 487 KEKL-RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS--KVDEN 543
+L R K V LEEA +L++ +L S K D+
Sbjct: 779 IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR 838
Query: 544 NANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK---S 600
L S +I A + + EE + +EK ++ EL+ + +K+E S+K S
Sbjct: 839 IEELEEALRESVQITAEREMVLAQEESARTNAEK--QVEELLMAMEKVKQELESMKAKLS 896
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
EKET + L +++ E+ +MK + L+ K
Sbjct: 897 STQQSLAEKETHLTNLRAE---RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK 953
Query: 661 LLEQNLALKEQ 671
E+ ALK +
Sbjct: 954 TQEEVAALKRE 964
Score = 65.3 bits (152), Expect = 1e-09
Identities = 109/548 (19%), Positives = 228/548 (41%), Gaps = 49/548 (8%)
Query: 39 ETQSNPIKLQDSGTITISCKMCQSLKESSNEI---NLKLEKLSGELFDIKEQ----KSAL 91
E Q +K + +G ++ Q L E+ KLE L+ + D K+ K +L
Sbjct: 451 EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 510
Query: 92 EGKYQNL-ILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTL 150
K Q IL+T+ D L +++ E K K+I+++ + T++ +I++L++ D
Sbjct: 511 TAKEQRAAILQTEV-DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
Query: 151 SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKEN 210
+ + +NL +++ D +K L ++ L+ ++ A L+E
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT--------ALTTLEEA 621
Query: 211 LIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
L + + T+ +L D + + Q E+D ++D K+L E + ++ L
Sbjct: 622 LAEK-----ERTIERLKEQ-RDRDEREK-------QEEIDNYKKDLKDLKEKVSLLQGDL 668
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E ++ +DL E K + ++ L E+ + ES+ K H
Sbjct: 669 SEKEASL-LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH------ 721
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
A L+A D + L + I +Y+ + + + ++ L E +E ++K
Sbjct: 722 --EAALEARASPEMSDRIQHL-EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID 450
+A L Q+ ++ L+ KE++ + SA ++ ++ + +++ + K D
Sbjct: 779 IAELERQVKDQNKKVANLK-HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
Query: 451 IPRDLDQDLPAHKKITILFDALITQYELSRTDYE--IEK-----EKLRLETGTAKAVXXX 503
+L++ L +IT + ++ Q E +RT+ E +E+ EK++ E + KA
Sbjct: 838 RIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS 897
Query: 504 XXXXXXXXXXXFDTLE-EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
L E ++ + E + + + E +AN+ L+++ S + +
Sbjct: 898 TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 957
Query: 563 AIAKNEEK 570
A EK
Sbjct: 958 VAALKREK 965
Score = 54.0 bits (124), Expect = 3e-06
Identities = 55/237 (23%), Positives = 101/237 (42%), Gaps = 13/237 (5%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
RS S ++V QLKE L S + + ++LK++ L E + L +D + L+ +
Sbjct: 430 RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL 489
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
+L Q S+ K+ I + + + T+ D L + M +K K++
Sbjct: 490 ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN----KKTKQI 545
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL- 998
EE + ++ + + K K+ E +++L D + ++ LK+R K L
Sbjct: 546 QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
Query: 999 ------DEECETCAEYLKQREEQCKRLKEA--KIALEIVDKLSNQKVALEKQIESLS 1047
D T E L ++E +RLKE + E +++ N K L+ E +S
Sbjct: 606 ADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
Score = 53.6 bits (123), Expect = 4e-06
Identities = 122/609 (20%), Positives = 252/609 (41%), Gaps = 59/609 (9%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
I+ N + QDS + T + + +E+ ++ + E+ + ELF +++ +E
Sbjct: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEME----- 292
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN 157
L +ETQ + L +D+ IK L + L++K +E+++ L E
Sbjct: 293 LRIETQKQTL------------NARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEA 339
Query: 158 VTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHI 217
+L ++ +K N L + ++ + + + K + ++K++ I S+
Sbjct: 340 EMHVHHLESLLEQKEKENSMLRE---EMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 218 GYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNM 277
G + ++ S+ ST + +++ R K + +K L E
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEERE--EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESKKSKDHIDRYKDSLLAV 335
+L +K + + +S L +L +L + N+ SK HI+ K+SL A
Sbjct: 455 E-ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 513
Query: 336 LD-AEFGTTSLDVFEILM---DNIINKYQIDLDEILEKYTKVQGDLNECTSEL----KSV 387
A T +D + + + ++NK + ++ E+ G++++ L + V
Sbjct: 514 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
Query: 388 N---EKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
N +K+ +L QL +KE + L KER+ + A T + L+E L ++ +
Sbjct: 574 NVLQKKIENLQEQLRDKEKQMSSL---KERVKSL-QADTTNTDTALTTLEEALAEKERTI 629
Query: 445 SKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT-AKAV 500
+LK RD +++ +KK L D L + L + D EKE L+ A ++
Sbjct: 630 ERLKEQRDRDEREKQEEIDNYKK--DLKD-LKEKVSLLQGDLS-EKEASLLDLKEHASSL 685
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA--NLNLIKILSEEID 558
LE+ E + +L K +++ ++ + + I+ L EI
Sbjct: 686 ASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745
Query: 559 ALKIAIAKNE---EKMLSL-----SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE 610
K +K + +++L + +EK++K ++ +K++N + +L EK+
Sbjct: 746 RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK 805
Query: 611 TQASELERS 619
A LE +
Sbjct: 806 KSAQMLEEA 814
Score = 44.8 bits (101), Expect = 0.002
Identities = 61/284 (21%), Positives = 122/284 (42%), Gaps = 14/284 (4%)
Query: 57 CKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR-DLLMSQIKSL 115
C +S + ++E L+ + S E+ D + +Y++ + Q D L+ +K +
Sbjct: 710 CLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 768
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKEVDDL 171
E E KDK+I L +K ++KK+ L Q E + ++ E DNLN L
Sbjct: 769 ENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 828
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKN-ICAQCKLK----ENLIQSLHIGYDNTLSKL 226
+ + + +LE+ + ES + + AQ + E ++ L + + +L
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 888
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
S+ +ST+ + + ++ L R + ++ E+ +K L + D + L
Sbjct: 889 E-SMKAKLSSTQQS-LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDANIALL 945
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
E + + K + ++ +KR + L +QL + K D Y+D
Sbjct: 946 ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 989
>AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein.
Length = 1302
Score = 71.3 bits (167), Expect = 2e-11
Identities = 155/838 (18%), Positives = 333/838 (39%), Gaps = 47/838 (5%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K LE E + I+ SL +SKK E++ TL T D+ K++
Sbjct: 469 KVLETEGSQESTVIR--APSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKT 526
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ TQ DL K G + + Q E + + Y S N +
Sbjct: 527 FPSASNTQATPDLLK---------GQQELTQQTN--EETAKQILYNYLKEGSTDNDDATK 575
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + KI TL+S + + C + +K+ LE + +T+++ E L + E
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAE-LQRQLQLE 633
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
K + + E + + + E+L + ++K +++ + L + E ++F++ M
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKM 691
Query: 353 DNIINKYQI-DL-DEILEKYTKVQGDLNECTSELKSVNEKLAS----LNSQLIEKENACN 406
+ ++ +I DL D++ E + ++ E ++ E+L L LI KE +
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKI 465
+LR ++ + + A+ ++ + E+ ++ + +L L+ + ++ A +
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
T D T+ + E EK + R E + + +TL++
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E++ L E L K + + +A + L E++A + +++ ++ LSEK + +E
Sbjct: 872 EIRQLEEALVHARKEEKEAVSAR----RALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927
Query: 584 LVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ LK E N L I + ++ A +E S + +LD+ K
Sbjct: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI-- 700
++++ + EE+ RD R + T + E + +
Sbjct: 988 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
Query: 701 -MRLQKQIQED-DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + +++D +L + E K+++L + E + + D + + SRE + QL + +L
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQL--RNEL 1105
Query: 759 VEGRIA--ELESD-IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R A +LE D I E+ +L + + +
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + + ++KE ++ E L ++ +L + ++E +E+ RL
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+ K L+++ L+EQ+ + ++ Q ++ D L S V+D M D ++
Sbjct: 1226 ESSKKKLQRE---LEEQMDMNEHLQGQLN----SMKKDLRLKKLPSKVLDDMDDDDDL 1276
Score = 63.3 bits (147), Expect = 5e-09
Identities = 125/567 (22%), Positives = 244/567 (43%), Gaps = 57/567 (10%)
Query: 519 EEAHNEVKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKM 571
EE + ++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E +
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 572 LS---LSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQ 621
S SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ +
Sbjct: 807 ASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 622 VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRD 678
+K+ E+ +++ ++ +E A+ L Q ++Q EK ++
Sbjct: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDA 737
S + ++ + E + + + +++Q++ +E T EL N+ + K
Sbjct: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
Query: 738 AVKDL-----ESSREAV-NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
+ ++ E + EA ++LT K E R+ +E ++R Q A
Sbjct: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL--MEEELRDYQRAQ----------DEAL 1032
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
T D +L L D R + + D +VSQL+ L + D L ER
Sbjct: 1033 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLSERI 1091
Query: 852 KELDDECETCA-EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
++ E E LQER + L+ +K+SLE+Q +LK +I + R +K + V
Sbjct: 1092 SRSREQMEQLRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSYRSSK-EGLVV 1149
Query: 911 NTDEDWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ A L + A ++ N+RL + ++EL + D ++T + + K
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK 1209
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIA 1025
A ++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+
Sbjct: 1210 ------AMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP 1263
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVS 1052
+++D + + L SL PVS
Sbjct: 1264 SKVLDDMDDDD-DLSTDGGSLYEAPVS 1289
Score = 62.5 bits (145), Expect = 8e-09
Identities = 147/742 (19%), Positives = 305/742 (41%), Gaps = 55/742 (7%)
Query: 25 NQLDGAKSKNDNIIETQSN-PIKLQD-SGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
NQ + S+ +++E +S I++ + + + K Q++KE + LE+L +
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E+ S L+ + + E + R L ++ ++ME EI++L D L +++
Sbjct: 660 EKVEENSTLQQRLEES--EGELRKNL-EELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI-DLEKLVNESENKIGPKNI 201
+ D ++E + ++ +++ K+ E L +K +L L + ++ +
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD-AGRE-DCKEL 259
KLKE YD L L S+ ++ + + SE D AG E K L
Sbjct: 777 -EMDKLKEQ--------YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E+ ++ E E + L ++ + E KA + + + + + L E L++ K
Sbjct: 828 QEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-K 885
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K+ + + +L L+A G S E + K + + ++ E+ +++ ++
Sbjct: 886 EEKEAVSARR-ALENELEAAQGNLSQTTQE--QKQLSEKLKEESEQ-KEQLRRLKNEMEN 941
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE-ILT 438
L EKL + ++E + L +Q + + E ++ + + +LKE L
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 439 KECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLETG 495
E +L+ +K+ D R ++++L +++ L + + L +YE+E K L+
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDD 1058
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
++ V LEE N L E +++ + ++++ L + +
Sbjct: 1059 RSRLVKQMEDKVSQLEME----LEEERNNSDLLSERISRS-REQMEQLRNELLQERAARQ 1113
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+++ KI++ + + + S ++ L + KE L + E E +
Sbjct: 1114 DLECDKISLERQNKDLKS------RIIHLEGSYRSSKE---GLVVQMEARIAELEDRLES 1164
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
ER ++ + L++ +++M D+ L + A+K Q EE
Sbjct: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEHLSLT------DQKDQLSLRLKAMKRQVEEA 1218
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ RLE + K ++ E Q M LQ Q+ ++K+ +L +L +K D
Sbjct: 1219 EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS-----MKKDLRLKKLPSKVLDDMDDD 1273
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
D D S EA T KD
Sbjct: 1274 DDLSTDGGSLYEAPVSYTFSKD 1295
Score = 59.3 bits (137), Expect = 8e-08
Identities = 99/448 (22%), Positives = 194/448 (43%), Gaps = 58/448 (12%)
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
NL ++ K+R + N + T+E+++ + + + I+ + ++++ +L E+
Sbjct: 579 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQL-EV 634
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
N+ + +K + + +LE R N+ + ++ R+ E E ++R
Sbjct: 635 KNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
DE DS KRS D E L E LL +Q+L
Sbjct: 694 EQHQTEIRDLQDQLSEMHDEL----------DSAKRS----EDREKGALIEELLQAKQDL 739
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLK---KEKLSL-EQQVSNLKEQIRTQ---- 896
DL +E +D L++R+ + LK KE++S +Q++ LKEQ +
Sbjct: 740 QDLLIAKEEQED-------LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 897 -QPVERQAKFADVAV---NTDE-DWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKK 950
+ VE K +V NT E D A V + +++ +++ L + + +L+ +
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFE-----AKRKELEDCKA------ELEELKQRYKELD 999
+DLK K ++ ++KY + ++ E A+++E E A ELE + +
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+E + +E LK+ EQ ++L+ K +++ N++ L K IE L +++
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLK------NEMENERWHLGKTIEKLQK-EMADIVEASR 965
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
T + +QNQ K ++L +M +L
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQL 993
Score = 57.2 bits (132), Expect = 3e-07
Identities = 116/561 (20%), Positives = 226/561 (40%), Gaps = 37/561 (6%)
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
+EVK L E+ +KL +V E L L + I + + N E++ S + + K+
Sbjct: 607 SEVKDLLEQKSKL-TIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS--QHNEKVE 663
Query: 583 ELVSTINGLKEENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E + L+E L K+L ++ + E + + E I+ +L +M ++
Sbjct: 664 ENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTE-----IRDLQDQLSEMHDELDSAK 718
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+AK L+ L KE+ E+ R R +K K + M
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
K+ Q D +L +E+ + E T E L + + +D + V L + + ++G
Sbjct: 779 DKLKE-QYDAELQALRES-VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQG 836
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
R ELE + Q + + K S +R+
Sbjct: 837 RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA 896
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ ++E+ + L QE L E+ KE ++ E E + + L K
Sbjct: 897 L----ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLM 940
L+++++++ E RT +E Q + + + A + + ++ E EK++ M
Sbjct: 953 LQKEMADIVEASRTST-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAM 1008
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAEL----- 988
K +E+R +++L++ +A+ K T KD E+E AK L+D ++ L
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQME 1067
Query: 989 EELKQRYKELDEE---CETCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIE 1044
+++ Q EL+EE + +E + + EQ ++L+ + L K++LE+Q +
Sbjct: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 1045 SLSNTPVSNSTMYVATGSAIV 1065
L + + Y ++ +V
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLV 1148
>AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 792
Score = 71.3 bits (167), Expect = 2e-11
Identities = 123/577 (21%), Positives = 253/577 (43%), Gaps = 49/577 (8%)
Query: 69 EINLKLEKLSGEL-FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIK 127
E+ ++ E E+ F +KE ++ Q E ++ Q+ L ++ K+ ++K
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE---KQVSLLLIQITEKENKMK 283
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEK 187
+LT L+ K+N+L+E+ S + +++ + +L KE++D+K + Q+ + +K
Sbjct: 284 DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS----LQRSVSTQK 339
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
+ E + +I K IC + KE ++ ++ ++ S + T +C+L+
Sbjct: 340 AL-EEDLQIATKTICQLTEEKETQME------ESNKARAAHSFVVTEFET---TVCSLE- 388
Query: 248 ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN 307
EL + E ED I +EL + + ++ KL N E E + +K + K L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILT-MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL- 446
Query: 308 SLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEIL 367
L E N + +K + + + L+ +L A + EI + I Q E+
Sbjct: 447 -LYE---NKQFEKIAEELKGTEQELIGLLQAR--EKEVHDLEIQLTAITTSEQYYSKEVK 500
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSAVTIDI 426
+ T+++ + + T EL S KL+ N +L ++ + + L+ Q+E I+ + +
Sbjct: 501 DLKTELENEKLKNT-ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERM 558
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
+K+ L+E T+ +L ++ ++ + D+ K + L Q E ++ Y
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVE-NKNKY--- 614
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNAN 546
E+L+ E K + LE K E+T Y+ ++++ +
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Query: 547 LNLIKILSEEIDALKIAIAKNEEKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDV 604
+ L EE++ K+ IA K+ +K +K+ E+V+ + K + + + D
Sbjct: 675 ---EENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
Query: 605 ---ITREKETQASELERSCQVIKQNGFELDKMKADIL 638
+ + KE + S L S ++ EL +KA++L
Sbjct: 731 ELGLYKSKEQEQSSLRASLEI------ELSNLKAELL 761
Score = 56.8 bits (131), Expect = 4e-07
Identities = 109/536 (20%), Positives = 221/536 (41%), Gaps = 56/536 (10%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLS 575
L+E + +++ L +E K K E +L LI+I +E + L + ++ +K+ L
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDK--EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDV---ITREKETQASELERSCQVIKQNGFELDK 632
EK +E + ++++++ K L D+ + R TQ + LE Q+ + +L +
Sbjct: 301 EKTKLQSENLK--QSIEKQHHLTKELEDIKVSLQRSVSTQKA-LEEDLQIATKTICQLTE 357
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
K + + LE+ L ++Q EK D +L+I T
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNED--QLKI------LT 409
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E+Q + +++E KL KE +L EL K K K E E +
Sbjct: 410 MELQKK-----SSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKG- 462
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T+++L+ G + E ++ + + E +DL
Sbjct: 463 -TEQELI-GLLQAREKEVHDLEIQLTAITTSEQY--------------YSKEVKDL--KT 504
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+L++ ++ + S L+ + L+ QE D+ K ++ + + +Q
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELT--QETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
L++ + L ++ ++E+++ Q+ E + K ++E+ NL V ++ Y E
Sbjct: 563 ENLQETETQLRNELEYVREELK-QKRDEVKCKLD----KSEENCNNLRKQVENKNKYIEE 617
Query: 933 VEK-NKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF-EAKRKELEDCKAEL 988
+++ NK L K T E + ++K V K++ +E +K E + +KE+ED K
Sbjct: 618 LQQENKALKKKGTAESKQLNVYEIK--VNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
E L + ++ + + K+ +++C+ +AL K K+ E+ E
Sbjct: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSE 731
Score = 50.8 bits (116), Expect = 3e-05
Identities = 61/268 (22%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
++++ + ++ L++ +++ +L+++ + +E L++ E+ L KE LE +
Sbjct: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE---LEDIKVS 330
Query: 889 LKEQIRTQQPVERQAKFADVAVN--TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
L+ + TQ+ +E + A + T+E + R ++ V + + + ++EEL
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL 390
Query: 947 -RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC 1005
R ++Q L+ +++ + KK E E K + + ELEELK K L E+ ET
Sbjct: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK---KVLGEK-ETL 446
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
KQ E+ + LK + E++ L A EK++ L + T S
Sbjct: 447 LYENKQFEKIAEELKGTE--QELIGLLQ----AREKEVHDL------EIQLTAITTSEQY 494
Query: 1066 QNQQITDVMKENQKLKKMNAKLITICKK 1093
++++ D+ E + K N +L + C K
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNK 522
Score = 47.2 bits (107), Expect = 3e-04
Identities = 124/576 (21%), Positives = 250/576 (43%), Gaps = 60/576 (10%)
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+SK+ EN KI+ + A++ NE+ L L E + +L+ +ENN
Sbjct: 131 ESKLQENR------KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI-------KENN 177
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+ + L +++ KET A RS + K+ +E ++ + +
Sbjct: 178 ATRHLCNLL---KETCA----RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
Query: 657 EAK-SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+A+ S LE + LKE EK + + E + ++K ++ +I +K+ + D F+
Sbjct: 231 QAENSRLEMHFKLKED-YEKIQHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 716 --EKETKLNELTNK----YEALKRDYDA---AVKDLESSREAVNQ-LTTQKDLVEG-RIA 764
E K+N+L K E LK+ + K+LE + ++ + ++TQK L E +IA
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 765 ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD--DSPKRSI 822
TE+ T E E +L+ + + +
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 823 SVISDSEVSQLKE--RLLSCQQ-ELDDLKERYKELD------DECETCAEYLQERDEQCA 873
++ + S+L+E +L + ++ EL++LK+ E + + E AE L+ +++
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L + + E++V +L+ Q+ E+ + T+ + L + + +
Sbjct: 469 GLLQAR---EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSL 525
Query: 934 EKNKRLMKTIE---ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELE 989
E + +T + EL+ +++D+ N K ++ M K + +E E + R ELE + EL+
Sbjct: 526 ENKELTQETSDMTLELKNQQEDINNN-KKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 990 ELKQRYK-ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + K +LD+ E C KQ E + K ++E L+ +K +K E + L+
Sbjct: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAES--KQLNV 638
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ + + + SA + +ITD ++ + KK++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
Score = 44.8 bits (101), Expect = 0.002
Identities = 98/533 (18%), Positives = 203/533 (38%), Gaps = 45/533 (8%)
Query: 270 LELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
L+ +++ L+E + EN + +K + + N L E + K K +R +
Sbjct: 151 LQFGNEKVSLKLEEGIQENKDL----IKENNATRHLCNLLKETCARSAEKTKKYEYER-E 205
Query: 330 DSLLAVLDAEFGTTSL-DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
++ +D + FE L N ++ E Y K+Q E E+
Sbjct: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
Query: 389 EKLASLNSQLIEKENACN----ILRIQKERIHEISSAVTI--DIVKKENELKEILTKECL 442
++++ L Q+ EKEN +L +++++++ + + +K+ E + LTKE
Sbjct: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE-- 323
Query: 443 KLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXX 502
L +K+ + R + + + I + E T E + +
Sbjct: 324 -LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
Query: 503 XXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKI 562
LE+ +++K L EL K S+++E N ++ E++ LK
Sbjct: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKK-SSELEEMTKLTNNKEV---ELEELKK 438
Query: 563 AIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQV 622
+ + E +L ++ + ++ + G ++E L + + E Q + + S Q
Sbjct: 439 VLGEKE----TLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 623 IKQNGFELD-KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
+ +L +++ + L + + + L LK Q E+ + +
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
Query: 682 LEINIKTHEKTAEIQNRMIMRLQ------KQIQEDDKLFIEK-ETKLNELT------NKY 728
E +K E E + ++ L+ KQ +++ K ++K E N L NKY
Sbjct: 555 EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
Query: 729 --------EALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
+ALK+ A K L VN+L + + + + E+ + E
Sbjct: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
Score = 39.5 bits (88), Expect = 0.065
Identities = 57/274 (20%), Positives = 125/274 (45%), Gaps = 24/274 (8%)
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
V +++E+ Q + +L ++ ++ ++ +EL E + L+E ++ L KE +
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE---KNKRLM 940
+ LKE + E+ K+ T + + +L++ + ++ E+ +N RL
Sbjct: 181 HLCNLLKETCA--RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRL- 237
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
E+ +K LK K+Q ++Y K E K K++ ++ E + + K+L
Sbjct: 238 ----EMHFK---LKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 1001 ECETCAEYLKQREEQCKRLKE-AKIALE----IVDKLSNQKVALEKQIESLSNTPVSNST 1055
E + + Q EE+ K E K ++E + +L + KV+L++ S+S
Sbjct: 288 LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR---SVSTQKALEED 344
Query: 1056 MYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+ +AT + ++ M+E+ K + ++ ++T
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Score = 39.5 bits (88), Expect = 0.065
Identities = 65/272 (23%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTRDLL---MSQIKSLE 116
+ L + ++++ L+L+ ++ + K+Q+ + + +NL ETQ R+ L ++K
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 117 ME---NLTKDKE-IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK---EVD 169
E L K +E NL ++ K+K I ELQ+EN L + ES LN +V+
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK---KGTAESKQLNVYEIKVN 644
Query: 170 DLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-L 226
L+ E QK ++ + + KI +N+ + + K +I + + K
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIADEAVKLQKEIDKRC 703
Query: 227 NRSISD-----SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD- 280
I++ +Y+KI + + + G KE ++ +S++ LE+ N+ +
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIE-ERDSELGLYKSKE--QEQSSLRASLEIELSNLKAEL 760
Query: 281 LDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
L K E E K K+ E K N +L E+
Sbjct: 761 LSVKKQLEIEREEKE-KLKREAKENTATLKEK 791
>X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal mRNA
for myosin heavy chain light meromyosin region. ).
Length = 876
Score = 70.9 bits (166), Expect = 2e-11
Identities = 145/844 (17%), Positives = 348/844 (41%), Gaps = 74/844 (8%)
Query: 280 DLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL----------INNESKKSKDHIDRYK 329
+L+E++ KA K+ S++ R L +SE+L I K+ + +
Sbjct: 58 ELEEEIEAERTSRAKAEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKREAEFQKMRR 117
Query: 330 DSLLAVLDAEFGTTSL------DVFEI--LMDNI----------INKYQIDLDEI---LE 368
D A L E +L V E+ +DN+ ++ ++++D++ +E
Sbjct: 118 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNME 177
Query: 369 KYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVK 428
+K +G+L + +++ ++L+ + ++ E++ N L Q+ R+ + + + +
Sbjct: 178 TVSKAKGNLEKM---CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEYSRQLDE 234
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
K+ L+ L++ ++ ++ R L++++ A + + +L R YE E+E
Sbjct: 235 KDT-LETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQE 293
Query: 489 -KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL--TKLYKSKVDENNA 545
K L+ +KA EE K L + L + + V+ A
Sbjct: 294 AKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCA 353
Query: 546 NLNLIK-ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
+L K L E++ L I + + +L +K ++++ EE +++ +
Sbjct: 354 SLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKILAEWKQKCEETHAVL---ES 410
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+E + ++EL + +++ +L+ +K + E + +
Sbjct: 411 FQKESRSLSTELFKIKNAYEESLDQLETLKRE----NKNLQQEISDLTEQIAEGGKRIHE 466
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
+K+Q E++ S L+ ++ E + E + I+R+Q ++ +++ E + K+ E
Sbjct: 467 LEKIKKQVEQEK---SELQAALEEAEASLEHEEGKILRIQLEV---NQVKSEVDRKIAEK 520
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
+ + +KR++ + ++S+ A ++ ++ D + + ++E D+ + +
Sbjct: 521 DEEIDQMKRNHIRIEESMQSTLNA--EIRSRNDAIRLK-KKMEGDLNEME---IQLNHAN 574
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
D L + + + K ++++ + + L+ + + L
Sbjct: 575 RMAAEDLRNYQNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRATL 633
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
+ + K + E +E +Q Q L K LE +S ++ ++ R A+
Sbjct: 634 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIKEARNAE 693
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKA 963
+ A D A + + A +E+ K L +T+++L+++ + + Q A
Sbjct: 694 --EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE------QLA 745
Query: 964 MEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEA 1022
++ K+ ++ EAK +ELE + ++E + + K L + E Q EE K +
Sbjct: 746 LKGGKKQIQKLEAKVRELEGEVESEQKRNVEAVKGLHKHERKVKELTYQTEEDRKNILRL 805
Query: 1023 KIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ ++VDKL + + ++Q E N + + + + ++ D+ + ++ K
Sbjct: 806 Q---DLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAE--SQVNK 860
Query: 1083 MNAK 1086
+ K
Sbjct: 861 LRVK 864
Score = 67.7 bits (158), Expect = 2e-10
Identities = 132/727 (18%), Positives = 294/727 (40%), Gaps = 56/727 (7%)
Query: 77 LSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
LS EL +I E+ G I + R+ +++ ++E T E T K
Sbjct: 80 LSRELEEISERLEEAVGATSTQIEMNKKREAEFQKMRR-DLEEATLQHEATAAT-LRKKH 137
Query: 137 SKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
+ + EL E+ D L + + E + E+DDL N E +++ +LEK+ E+++
Sbjct: 138 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 197
Query: 197 GPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGR--- 253
++ K KE Q L D T + + S + ++ TL+++L G+
Sbjct: 198 ------SEIKTKEEEQQRLI--NDLTAQRARLQQNQVEYSRQLDEKDTLETQLSRGKQAF 249
Query: 254 ----EDCKELCEDFTSIKNHLELHEPNMTMDLD---EKLGENNEFETKAVKVMSEIKRNL 306
E+ K E+ K+ L + D D E+ E E + + + MS+ +
Sbjct: 250 TQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEV 309
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEI 366
+ + +++++ + K + DAE +++ ++ + Q +++++
Sbjct: 310 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 369
Query: 367 LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDI 426
+ D+ + ++++K + + L E + C E + S +++ ++
Sbjct: 370 MI-------DVERTNAACAALDKKQTNFDKILAEWKQKCEETHAVLESFQKESRSLSTEL 422
Query: 427 VKKENELKEILTK-ECLKLSKLKIDIP-RDLDQDLPAHKKITILFDALITQYELSRTDYE 484
K +N +E L + E LK + DL + + K + + Q E +++ +
Sbjct: 423 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 482
Query: 485 IEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH----EELTKLY 536
E+ L E G + +E +++K H E +
Sbjct: 483 AALEEAEASLEHEEGKILRIQLEVNQVKSEVDRKIAEKDEEIDQMKRNHIRIEESMQSTL 542
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+++ N + L K + +++ ++I + + +M + ++ + T+ + L ++
Sbjct: 543 NAEIRSRNDAIRLKKKMEGDLNEMEIQL-NHANRMAAEDLRNYQNTQAILKDTQL-HLDD 600
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+L+S D+ KE Q + +ER +++ E+++++A + +
Sbjct: 601 ALRSQEDL----KE-QLAMVERRANLLQA---EIEELRATLEQTERSRKIAEQELLDASE 652
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
+ L QN +L ++ D S+++ ++ K A R K+ D + E
Sbjct: 653 RVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIKEA----RNAEEKAKKAITDAAMMAE 708
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT-----TQKDLVEGRIAELESDIR 771
+ K + + E +K++ + VKDL+ + QL Q +E ++ ELE ++
Sbjct: 709 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAKVRELEGEVE 768
Query: 772 TEQTATV 778
+EQ V
Sbjct: 769 SEQKRNV 775
Score = 50.8 bits (116), Expect = 3e-05
Identities = 57/278 (20%), Positives = 120/278 (43%), Gaps = 15/278 (5%)
Query: 810 ENPKLDDSPKRSISVIS--DSEVSQLKERLLSCQQELDDLKERYKELDDECE----TCAE 863
+ +LD+ K+ +S S++ + + Q+++ +L+ R +EL++E E + A+
Sbjct: 13 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERTSRAK 72
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+ R + L++ LE+ V QI + +R+A+F + + +E +
Sbjct: 73 AEKLRSDLSRELEEISERLEEAVGATSTQIEMNK--KREAEFQKMRRDLEEATLQHEATA 130
Query: 924 VDRMSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
A+ E+ L + ++L +K ++K + + ME +K E
Sbjct: 131 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMC 190
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ LED +E++ ++ + L + L+Q + + R + K LE +LS K A
Sbjct: 191 RALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEYSRQLDEKDTLE--TQLSRGKQA 248
Query: 1039 LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
+QIE L A A+ ++ D+++E
Sbjct: 249 FTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE 286
Score = 40.3 bits (90), Expect = 0.037
Identities = 55/288 (19%), Positives = 117/288 (40%), Gaps = 29/288 (10%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
D +++ K++ L+ ++ + L E +E +Q LK+E +L+Q++
Sbjct: 391 DKILAEWKQKCEETHAVLESFQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEI 450
Query: 887 SNLKEQIR----------------TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
S+L EQI Q+ E QA + + + + + + ++
Sbjct: 451 SDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEVNQVK 510
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+EV+ +++ + EE+ K++ MQ + + + +K++E +L E
Sbjct: 511 SEVD--RKIAEKDEEIDQMKRNHIRIEESMQSTLNAEIRSRNDAIRLKKKME---GDLNE 565
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDKLSNQKVALEKQIESL 1046
++ +L+ AE L+ + LK+ ++ AL + L Q +E++ L
Sbjct: 566 ME---IQLNHANRMAAEDLRNYQNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLL 622
Query: 1047 -SNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ +T+ S + Q++ D + Q L N LI KK
Sbjct: 623 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 670
Score = 35.1 bits (77), Expect = 1.4
Identities = 30/158 (18%), Positives = 75/158 (47%), Gaps = 3/158 (1%)
Query: 932 EVEKNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
++E +K+ L + +++ ++ L++ + Q + KK KE +A+ +ELE+ + E E
Sbjct: 9 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE-EIEAER 67
Query: 991 L-KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
+ + ++L + E + +R E+ +I + + QK+ + + +L +
Sbjct: 68 TSRAKAEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKREAEFQKMRRDLEEATLQHE 127
Query: 1050 PVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+ + S +QI ++ + QKL+K +++
Sbjct: 128 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 165
>M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein.
Length = 2871
Score = 70.9 bits (166), Expect = 2e-11
Identities = 196/1026 (19%), Positives = 408/1026 (39%), Gaps = 105/1026 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS--L 115
+M +SL++ + N K+E L EL ++ S K + L Q SQ K+
Sbjct: 1019 EMLKSLEDLKLK-NTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES----------DNLN 165
+E L + E+ + + + K +++E N+ ++ L E E D
Sbjct: 1078 SLEELKRQAELDGKS-AKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQK 1136
Query: 166 KEVDDLKKNNEC----LTQKCIDLEKLVNESENKIGPKNICAQ-----CKLKENLIQSLH 216
+ D L+K +C L + ++ EK + E E +I + Q + EN + +
Sbjct: 1137 NDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVR 1196
Query: 217 IGYDNTLSKL-NRSISDSNTSTRYNKICTLQSELDAG--REDCKELCEDFTSIKNHL-EL 272
Y+ +S L N+ ++ N + K ++Q E D+ R L + +K+ + L
Sbjct: 1197 NHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL 1256
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL 332
++ + + E N + KA SEI + L +L ++S+D+ R+K SL
Sbjct: 1257 NDSILQATEQRRRAEENALQQKACG--SEIMQKKQHLEIELKQVMQQRSEDNA-RHKQSL 1313
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
E T D + I + + + E ++ + + +L++ + + +E++
Sbjct: 1314 -----EEAAKTIQD-----KNKEIERLKAEFQEEAKRRWEYENELSKVRN---NYDEEII 1360
Query: 393 SLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIP 452
SL +Q E E + I K IH+++ D ++ LT+E LS+ +
Sbjct: 1361 SLKNQF-ETE-----INITKTTIHQLTMQKEEDTSGYRAQIDN-LTRENRSLSEEIKRLK 1413
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
L Q +++ + I Q + + ++ K++L +E +
Sbjct: 1414 NTLTQTTENLRRV----EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK--- 1466
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+L++A ++ ++E+ +L K +D+ N K L +E A+ +
Sbjct: 1467 ---QSLDDAAKTIQDKNKEIERL-KQLIDKET---NDRKCLEDEN-------ARLQRVQY 1512
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L + ++ TE ++ + ++E L+ + +++E+ + ++ R +K+ + K
Sbjct: 1513 DLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQK 1572
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
++ ++ +E + + +LKEQ + T +LE +++
Sbjct: 1573 VEEELNRLKRTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRS 1629
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
+ + L ++E + + +L L+++ EAL+R +++ ES ++A +
Sbjct: 1630 EDDLRQQRDVLDGHLREKQRT----QEELRRLSSEVEALRRQL---LQEQESVKQAHLRN 1682
Query: 753 TTQKDLVEGRIAEL-ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
+ +E + L ES I E+ ++ E DL
Sbjct: 1683 EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRL-----EYDDLRRG 1737
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
DS K + + S++ R L Q ++DL+ + L E E
Sbjct: 1738 RSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE------------ 1785
Query: 872 CARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ +K+ L ++ K Q TQ ER++ + V ++D A L + + +
Sbjct: 1786 --KFQKQALEASNRIQESKNQC-TQVVQERESLLVKIKV-LEQDKARLQRLEDELNRAKS 1841
Query: 932 EVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+E R+ + +E E + + DL T+ + E K + E E +E ++E+E
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
L+ K ++E C E RE Q + E +DKL + ++ ++
Sbjct: 1902 LQAEIKRIEERCRRKLED-STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWT 1960
Query: 1051 VSNSTM 1056
V S +
Sbjct: 1961 VDTSKL 1966
Score = 59.3 bits (137), Expect = 8e-08
Identities = 160/800 (20%), Positives = 325/800 (40%), Gaps = 73/800 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL-FDI 84
+L+ K+ + E + + LQ+ GT + L + N N ++ L + +I
Sbjct: 1157 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYE--NELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
K+ + K ++ E +++L +Q+ L EN EI L DS+ +++ +
Sbjct: 1215 NITKTTI--KEISMQKEDDSKNL-RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE 1271
Query: 145 E---ENDTLSNLIMENVTESD-NLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKN 200
E + + IM+ + L + + ++N Q + K + + +I
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
Query: 201 ICAQCKLK-----ENLIQSLHIGYDNTLSKL-NRSISDSN-TSTRYNKICTLQSELDAG- 252
Q + K EN + + YD + L N+ ++ N T T +++ T+Q E D
Sbjct: 1332 AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL-TMQKEEDTSG 1390
Query: 253 -REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
R L + S+ ++ + +T E L E + SE+ + L
Sbjct: 1391 YRAQIDNLTRENRSLSEEIKRLKNTLTQTT-ENLRRVEEDIQQQKATGSEVSQRKQQLEV 1449
Query: 312 QLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
+L ++++ + RYK SL A + ++ + L+D N + L++ +
Sbjct: 1450 ELRQVTQMRTEESV-RYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC-LEDENARL 1507
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+VQ DL + S S E + L Q E LRI ER+ + + DI + +
Sbjct: 1508 QRVQYDLQKANS---SATETINKLKVQ----EQELTRLRIDYERVSQERTVKDQDITRFQ 1560
Query: 431 NELKEI-LTKECLK--LSKLKIDIPRD------LDQDLPAH----KKITILFDALITQYE 477
N LKE+ L K+ ++ L++LK D L+++L K+ I L Q E
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL-- 535
+ + ++ LR + +E ++ E + +
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
Query: 536 ----YKSKVDENNANLNLIKILSEEIDALKIAIAKN----EEKMLSLSEKDNKL----TE 583
++ +++ + +LN KI E + +L + K EE++ +L + + L +E
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
S N E S +++ T E + ++L+R + ++Q E++K + L
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQ---EIEKFQKQALEASNR 1797
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E +SLL + L++ +K R RLE + + T E + R+ RL
Sbjct: 1798 IQESKNQCTQVVQERESLLVKIKVLEQ---DKAR-LQRLEDELNRAKSTLEAETRVKQRL 1853
Query: 704 Q---KQIQED----DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ- 755
+ +QIQ D + KE + ++ ++ E +R+ ++ ++E + + ++ +
Sbjct: 1854 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERC 1913
Query: 756 KDLVEGRIAELESDIRTEQT 775
+ +E E +S + TE++
Sbjct: 1914 RRKLEDSTRETQSQLETERS 1933
Score = 32.7 bits (71), Expect = 7.5
Identities = 35/186 (18%), Positives = 83/186 (44%), Gaps = 16/186 (8%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKE-----KLSLEQQVSNLKEQIRTQQ 897
E+ +++ +E+ E CA +++ + Q A + +++ + + Q+
Sbjct: 936 EISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQE 995
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ A++ ++ + + + L ++ + D ++ KN ++ EELR +
Sbjct: 996 AADVHARYIELLTRSGDYYRFLSEML--KSLEDLKL-KNTKIEVLEEELRLARDANSENC 1052
Query: 958 TK---MQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQRE 1013
K + + ++KY + +F+AK LE+ K + E + K + LD+ C +K+
Sbjct: 1053 NKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----CYGQIKELN 1108
Query: 1014 EQCKRL 1019
E+ RL
Sbjct: 1109 EKITRL 1114
>AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250kDa
protein.
Length = 2442
Score = 70.9 bits (166), Expect = 2e-11
Identities = 184/1058 (17%), Positives = 440/1058 (41%), Gaps = 81/1058 (7%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIK----SLEM 117
SL + ++ ++E L +L + + +E + Q + ETQ + + +++ SL +
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
+ K++ + L ++ + ++++ L+++ E + + L +EV + K +
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADF 1117
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L Q+ LE+L + I + + A +E L + +T S+L ++
Sbjct: 1118 LAQEAQLLEEL---EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
+ L S A ++ +CE + + ++ D+ G + F K
Sbjct: 1175 QAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN-GARSLF--KRGP 1231
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+++ + + + ++ + K++ D +D + L+ T + ++ + +
Sbjct: 1232 LLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQK-LEERLTDTEAEKSQVHTE--LQ 1288
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
Q L + E+ +K +G N SEL ++E +ASL S+L E + R++ + E
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----LQRMEAQGERE 1344
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ A ++ + L+ + + + S I L++DL + L + + E
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGI-----LEEDLRTARSALKLKNE---EVE 1396
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYK 537
R + +E+ L+ KA+ + +E +++ L E+ ++ K
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQEL-EKQREMQK 1455
Query: 538 SKVDENNANLNL----IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+ ++ + +L + + E+I L+ + E +++ E++ KLT I L++
Sbjct: 1456 AALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK 1515
Query: 594 ENNSLKSL--NDVITREKETQASELERS-CQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
+ + +++ + ++ EK+ Q E +R Q +K+ L+ + ++
Sbjct: 1516 DRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL 1575
Query: 651 XXXXXDEAKS----LLEQNLALKEQCEEKTRDCSRLEINIKTH---------EKTAEI-- 695
+ ++ L L L+E+ +E S++ ++++H E+ E+
Sbjct: 1576 IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKS 1634
Query: 696 QNRMIMRLQKQIQE--------DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESS-R 746
Q I LQ+Q + D +L ++KE ++ L ++ + + ++ ++ S R
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLEQIKLSLR 1693
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
E +LTTQ+ L++ R E + + ++ + E +
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHEL-QELK 1752
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE----RYKELDDECETCA 862
D E R + S +SQ ++ ++ QQ+L + +E + + L + +
Sbjct: 1753 DQLEQQL--QGLHRKVGETS-LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
L +RD++ L++E+ + Q +KE+ Q Q A + + H
Sbjct: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQ---AHMTLKERHGELQDHKE 1866
Query: 923 VVDRMSYDAEVE--KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
R+ + VE + + L + + +LR + ++ + + +Q ++ ++ +E E + +
Sbjct: 1867 QARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ---QQCAEQAQEHEVETRA 1923
Query: 981 LEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKEA-KIAL-EIVDKLSNQKV 1037
L+D + + LK+R +EL E ++ + +EE + EA + AL + L ++
Sbjct: 1924 LQDSWLQAQAVLKERDQEL-EALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ 1982
Query: 1038 ALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMK 1075
L +Q E + S +T+ + + ++Q+ + ++
Sbjct: 1983 HLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
Score = 56.8 bits (131), Expect = 4e-07
Identities = 101/507 (19%), Positives = 200/507 (39%), Gaps = 30/507 (5%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
EE +++ L +E +L + V+ + E+ + L +A+ + E L +
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
K +E +S + L+E S +++ +E+ + L R+ Q I + + +K ++
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ L +Q L L+E E CSR+E + +N
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEE---ENQSVCSRMEA-------AEQARNA 642
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + L + + + L+ EK T L K E + A ++D++ +E + QK L
Sbjct: 643 LQVDLAEAEKRREALW-EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI-----QKKL 696
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
E R + + + EQ E R D
Sbjct: 697 SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE 878
++ + S E+ L+ L QQ+ ++ +L+ + +T Q ++ ++
Sbjct: 757 EQLQGLSSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT---QAKEVIQGEVRCL 811
Query: 879 KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD-EDWANLHSVVVDRMSYDAEVEKN- 936
KL L+ + S +++ + RQ A+ T E H V+++ E E++
Sbjct: 812 KLELDTERSQAEQE---RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW 868
Query: 937 --KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
+ L K +E L +K +L+ + + Q ME + +E E + E C+ +LE K+R
Sbjct: 869 HQQELAKALESLEREKMELEMRLKEQQTEMEAI-QAQREEERTQAESALCQMQLETEKER 927
Query: 995 YKELDEECETCAEYLKQREEQCKRLKE 1021
L+ +T E L +Q +RL++
Sbjct: 928 VSLLETLLQTQKE-LADASQQLERLRQ 953
Score = 54.4 bits (125), Expect = 2e-06
Identities = 145/763 (19%), Positives = 316/763 (41%), Gaps = 58/763 (7%)
Query: 66 SSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL-EMENLTKDK 124
S +E +L+L+ FD ++ AL L Q L Q+ E NL + +
Sbjct: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
+ K +++ +L E DTL+ ++ E D+L+KE + L+K E L Q+
Sbjct: 423 H-DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 185 LEK---LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS--DSNTSTRY 239
LE+ + ++ + AQ + KE + LH+ +L + ++ S
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQ-KEEQQEELHLAVRER-ERLQEMLMGLEAKQSESL 539
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGENNEFETKAVKV 298
+++ TL+ L++ + + L ++ T + L E ++ + E + + +A V
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599
Query: 299 -MSEIKRNLN----SLSEQLIN----NESKKSK-DHIDRYKDSLLAVL-DAEFGTTSLDV 347
+S + L L++QL+ N+S S+ + ++ +++L L +AE +L
Sbjct: 600 KLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 348 FEILMDNIINK-------YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
++ + K Q DL +I E+ ++Q L+E + ++ +L L+ +
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
Query: 401 KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLP 460
+E +KE + +A+ + + E + ++ L ++ LS K + L +
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQD-LAEQLQGLSSAKELLESSLFEAQQ 778
Query: 461 AHKKITILFDALITQYELSRTDYEI---EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ I + L Q + E+ E L+LE T ++ +
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
Query: 518 L-EEAHNEVKSLHEELTKLYKSKVDENNA-----NLNLIKILSEEIDALKIAIAKNEEKM 571
+ A + K+ HE+ + K ++ + ++ L E L++ + + + +M
Sbjct: 839 EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898
Query: 572 LSL-SEKDNKLTELVSTI--NGLKEENNSLKSLNDVITREKETQ--ASELERSCQVIK-- 624
++ ++++ + T+ S + L+ E + L ++ +KE + +LER Q +K
Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958
Query: 625 ------QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK--- 675
G +++ +E+ SLL+ + L++Q E+
Sbjct: 959 KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQ 1018
Query: 676 --TRDCSRLEINIKTHEKTAEIQ--NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL 731
+D S+ + + EK E Q NR+ L+++ +EKE +L L
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 732 KRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
+++ A +D++ ++ +L+ Q +L+ + E E+D ++
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/267 (20%), Positives = 124/267 (46%), Gaps = 8/267 (2%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
RS + + EV +ER + Q++ + + K L + + L ER+E+ L+ +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 880 LSLEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
LE+Q K + ++++ + D+ ++ SV+ + + + E+ ++
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL-EHLPMAVQ-EREQK 1502
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L E++R ++D + ++ + + KKD+ E++R +++D K +L L+ EL
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 999 DE---ECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESL-SNTPVSN 1053
+E + E + +K+ E Q + + A L + +++ S + A QI L S++ V
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKL 1080
+ Q +QI ++ ++ + L
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHL 1649
Score = 49.2 bits (112), Expect = 8e-05
Identities = 58/273 (21%), Positives = 121/273 (44%), Gaps = 12/273 (4%)
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
L++++ ++ L D + ++ E + L + E+ ++ + ++ SLE ++ L E
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 893 IRTQQPVERQAKFADVAVNTDEDWA-----NLHSVVVDRMSYDAEVEKNKRLMKTIEE-L 946
+ + Q R+A+ + + + NL + V + E +EE L
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
R + LK +++ E+ ++ E K + + + L L Q E +EE ET
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 1007 EYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL-EKQIESLS--NTPVSNSTMYV--ATG 1061
+++ E+Q + K A L + K NQ+V L ++QI+ L + + + M V
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 1062 SAIVQNQQITDVMKENQKLKK-MNAKLITICKK 1093
VQ +QI ++ K+ + + + +L+ + KK
Sbjct: 1502 KLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534
Score = 45.6 bits (103), Expect = 0.001
Identities = 77/424 (18%), Positives = 160/424 (37%), Gaps = 18/424 (4%)
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
EK A +++ +++L+ Q + ++ T+L+ L + + DY+ +K L + E +
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
T+ E ++ + + + + + +
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Query: 810 ENPKLDDSPK-----RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
D+ K RS+ V L+++L CQ+ ++ L++++ + ++E + +
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR 436
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
LQ+ + L + + L+ +V +L ++ Q + + + V E W L V V
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR-QQLEVLEQEAW-RLRRVNV 494
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ + K + EEL ++ + + K ++ E R+ LE
Sbjct: 495 ELQLQGDSAQGQKEEQQ--EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS 552
Query: 985 KAELEELKQRYKELD---EECETCAEYLKQREEQCKR----LKEAKIALEIVDK-LSNQK 1036
E E L+Q E+ E L E K L+ A + L +++ L+ K
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 1037 VALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRG 1095
V L +Q+ L S S M A + + + K + L + N L +K
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 1096 KTGA 1099
+ GA
Sbjct: 673 EAGA 676
Score = 43.2 bits (97), Expect = 0.005
Identities = 171/971 (17%), Positives = 363/971 (37%), Gaps = 79/971 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + E+ + + S EL +K Q + + Q+ + E L + + + +N
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE------LSALLTQSQKQNEDY 302
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK-KNNECLTQK 181
+K IK L ++++ EL E +LS E + K++ + + + + Q
Sbjct: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
Query: 182 CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK 241
L E ++ I + L++S+ + L + ++ +
Sbjct: 363 SGHENSL--ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL-- 418
Query: 242 ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE 301
LQ + D E+ K L + + + T+DL ++ ++ K E
Sbjct: 419 ---LQQQHDQWEEEGKALRQRLQKLTGERDTLA-GQTVDLQGEVDSLSKERELLQKAREE 474
Query: 302 IKRNLNSLSEQL-----INNESKKSKDHIDRYKDSL-----LAVLDAEFGTTSLDVFEIL 351
+++ L L ++ +N E + D K+ LAV + E L E
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAK 534
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDL-----NECTSELKSVNEKLASLNSQLIEKENACN 406
+++ I L E LE + ++G+L E T+ L + +A L+S +
Sbjct: 535 QSESLSEL-ITLREALES-SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI--DIPRDLDQDLP-AHK 463
LR ++ ++ A+ +D V +L ++ + S+++ L DL A K
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652
Query: 464 KITILFDA---LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+ L++ L Q + + + LR + + LE+
Sbjct: 653 RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ 712
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
H E K E L + + K + L E AL++ + E L+E+
Sbjct: 713 LHQEAKRQEEVLARAVQEK-----------EALVREKAALEVRLQAVERDRQDLAEQLQG 761
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI--L 638
L+ + E S+ +V + E Q + ++ +VI Q K++ D
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI-QGEVRCLKLELDTERS 820
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
E K+ LEQ A E+ E+N + EK + ++
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEK-----------EVN-QLREKWEKERSW 868
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
L K ++ ++ +E E +L E + EA++ + ES+ + QL T+K+
Sbjct: 869 HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM-QLETEKE- 926
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDS 817
R++ LE+ ++T++ T G L E + L ++
Sbjct: 927 ---RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA 983
Query: 818 PKRSISVIS--DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
++ ++ E S L + + Q++++DLK + DD + +QE+ +
Sbjct: 984 ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+ + LE++ ++L + ++ +R + ++ + L + + E+
Sbjct: 1044 NRIQKELEREKASLTLSLMEKE--QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
L++ +E++ K+ D ++ + +E +++ R L +A+ +L+ R
Sbjct: 1102 QMELLR--QEVKEKEADFLAQEAQLLEELEASHITEQQL---RASLWAQEAKAAQLQLRL 1156
Query: 996 KELDEECETCA 1006
+ + + E A
Sbjct: 1157 RSTESQLEALA 1167
Score = 41.5 bits (93), Expect = 0.016
Identities = 31/120 (25%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Query: 33 KNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE-QKSAL 91
K D +IE+Q ++ +T+ C + L+E+ +++ + +KL EL +E Q+ AL
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLEC-LALELEENHHKMECQ-QKLIKELEGQRETQRVAL 1590
Query: 92 EGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLS 151
+L +Q SQI LE + +E++ +K++ ++I ELQ + + L+
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
>AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein.
Length = 2871
Score = 70.9 bits (166), Expect = 2e-11
Identities = 196/1026 (19%), Positives = 408/1026 (39%), Gaps = 105/1026 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS--L 115
+M +SL++ + N K+E L EL ++ S K + L Q SQ K+
Sbjct: 1019 EMLKSLEDLKLK-NTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES----------DNLN 165
+E L + E+ + + + K +++E N+ ++ L E E D
Sbjct: 1078 SLEELKRQAELDGKS-AKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQK 1136
Query: 166 KEVDDLKKNNEC----LTQKCIDLEKLVNESENKIGPKNICAQ-----CKLKENLIQSLH 216
+ D L+K +C L + ++ EK + E E +I + Q + EN + +
Sbjct: 1137 NDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVR 1196
Query: 217 IGYDNTLSKL-NRSISDSNTSTRYNKICTLQSELDAG--REDCKELCEDFTSIKNHL-EL 272
Y+ +S L N+ ++ N + K ++Q E D+ R L + +K+ + L
Sbjct: 1197 NHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL 1256
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL 332
++ + + E N + KA SEI + L +L ++S+D+ R+K SL
Sbjct: 1257 NDSILQATEQRRRAEENALQQKACG--SEIMQKKQHLEIELKQVMQQRSEDNA-RHKQSL 1313
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
E T D + I + + + E ++ + + +L++ + + +E++
Sbjct: 1314 -----EEAAKTIQD-----KNKEIERLKAEFQEEAKRRWEYENELSKVRN---NYDEEII 1360
Query: 393 SLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIP 452
SL +Q E E + I K IH+++ D ++ LT+E LS+ +
Sbjct: 1361 SLKNQF-ETE-----INITKTTIHQLTMQKEEDTSGYRAQIDN-LTRENRSLSEEIKRLK 1413
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
L Q +++ + I Q + + ++ K++L +E +
Sbjct: 1414 NTLTQTTENLRRV----EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK--- 1466
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+L++A ++ ++E+ +L K +D+ N K L +E A+ +
Sbjct: 1467 ---QSLDDAAKTIQDKNKEIERL-KQLIDKET---NDRKCLEDEN-------ARLQRVQY 1512
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
L + ++ TE ++ + ++E L+ + +++E+ + ++ R +K+ + K
Sbjct: 1513 DLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQK 1572
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT 692
++ ++ +E + + +LKEQ + T +LE +++
Sbjct: 1573 VEEELNRLKRTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRS 1629
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
+ + L ++E + + +L L+++ EAL+R +++ ES ++A +
Sbjct: 1630 EDDLRQQRDVLDGHLREKQRT----QEELRRLSSEVEALRRQL---LQEQESVKQAHLRN 1682
Query: 753 TTQKDLVEGRIAEL-ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
+ +E + L ES I E+ ++ E DL
Sbjct: 1683 EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRL-----EYDDLRRG 1737
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
DS K + + S++ R L Q ++DL+ + L E E
Sbjct: 1738 RSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE------------ 1785
Query: 872 CARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
+ +K+ L ++ K Q TQ ER++ + V ++D A L + + +
Sbjct: 1786 --KFQKQALEASNRIQESKNQC-TQVVQERESLLVKIKV-LEQDKARLQRLEDELNRAKS 1841
Query: 932 EVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+E R+ + +E E + + DL T+ + E K + E E +E ++E+E
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
L+ K ++E C E RE Q + E +DKL + ++ ++
Sbjct: 1902 LQAEIKRIEERCRRKLED-STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWT 1960
Query: 1051 VSNSTM 1056
V S +
Sbjct: 1961 VDTSKL 1966
Score = 59.3 bits (137), Expect = 8e-08
Identities = 160/800 (20%), Positives = 325/800 (40%), Gaps = 73/800 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL-FDI 84
+L+ K+ + E + + LQ+ GT + L + N N ++ L + +I
Sbjct: 1157 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYE--NELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
K+ + K ++ E +++L +Q+ L EN EI L DS+ +++ +
Sbjct: 1215 NITKTTI--KEISMQKEDDSKNL-RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE 1271
Query: 145 E---ENDTLSNLIMENVTESD-NLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKN 200
E + + IM+ + L + + ++N Q + K + + +I
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
Query: 201 ICAQCKLK-----ENLIQSLHIGYDNTLSKL-NRSISDSN-TSTRYNKICTLQSELDAG- 252
Q + K EN + + YD + L N+ ++ N T T +++ T+Q E D
Sbjct: 1332 AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL-TMQKEEDTSG 1390
Query: 253 -REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
R L + S+ ++ + +T E L E + SE+ + L
Sbjct: 1391 YRAQIDNLTRENRSLSEEIKRLKNTLTQTT-ENLRRVEEDIQQQKATGSEVSQRKQQLEV 1449
Query: 312 QLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
+L ++++ + RYK SL A + ++ + L+D N + L++ +
Sbjct: 1450 ELRQVTQMRTEESV-RYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC-LEDENARL 1507
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+VQ DL + S S E + L Q E LRI ER+ + + DI + +
Sbjct: 1508 QRVQYDLQKANS---SATETINKLKVQ----EQELTRLRIDYERVSQERTVKDQDITRFQ 1560
Query: 431 NELKEI-LTKECLK--LSKLKIDIPRD------LDQDLPAH----KKITILFDALITQYE 477
N LKE+ L K+ ++ L++LK D L+++L K+ I L Q E
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL-- 535
+ + ++ LR + +E ++ E + +
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
Query: 536 ----YKSKVDENNANLNLIKILSEEIDALKIAIAKN----EEKMLSLSEKDNKL----TE 583
++ +++ + +LN KI E + +L + K EE++ +L + + L +E
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
S N E S +++ T E + ++L+R + ++Q E++K + L
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQ---EIEKFQKQALEASNR 1797
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E +SLL + L++ +K R RLE + + T E + R+ RL
Sbjct: 1798 IQESKNQCTQVVQERESLLVKIKVLEQ---DKAR-LQRLEDELNRAKSTLEAETRVKQRL 1853
Query: 704 Q---KQIQED----DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ- 755
+ +QIQ D + KE + ++ ++ E +R+ ++ ++E + + ++ +
Sbjct: 1854 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERC 1913
Query: 756 KDLVEGRIAELESDIRTEQT 775
+ +E E +S + TE++
Sbjct: 1914 RRKLEDSTRETQSQLETERS 1933
Score = 32.7 bits (71), Expect = 7.5
Identities = 35/186 (18%), Positives = 83/186 (44%), Gaps = 16/186 (8%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKE-----KLSLEQQVSNLKEQIRTQQ 897
E+ +++ +E+ E CA +++ + Q A + +++ + + Q+
Sbjct: 936 EISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQE 995
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ A++ ++ + + + L ++ + D ++ KN ++ EELR +
Sbjct: 996 AADVHARYIELLTRSGDYYRFLSEML--KSLEDLKL-KNTKIEVLEEELRLARDANSENC 1052
Query: 958 TK---MQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQRE 1013
K + + ++KY + +F+AK LE+ K + E + K + LD+ C +K+
Sbjct: 1053 NKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----CYGQIKELN 1108
Query: 1014 EQCKRL 1019
E+ RL
Sbjct: 1109 EKITRL 1114
>AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associated
protein 1 protein.
Length = 2442
Score = 70.9 bits (166), Expect = 2e-11
Identities = 184/1058 (17%), Positives = 440/1058 (41%), Gaps = 81/1058 (7%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIK----SLEM 117
SL + ++ ++E L +L + + +E + Q + ETQ + + +++ SL +
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
+ K++ + L ++ + ++++ L+++ E + + L +EV + K +
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADF 1117
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L Q+ LE+L + I + + A +E L + +T S+L ++
Sbjct: 1118 LAQEAQLLEEL---EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
+ L S A ++ +CE + + ++ D+ G + F K
Sbjct: 1175 QAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN-GARSLF--KRGP 1231
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+++ + + + ++ + K++ D +D + L+ T + ++ + +
Sbjct: 1232 LLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQK-LEERLTDTEAEKSQVHTE--LQ 1288
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
Q L + E+ +K +G N SEL ++E +ASL S+L E + R++ + E
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----LQRMEAQGERE 1344
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
+ A ++ + L+ + + + S I L++DL + L + + E
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGI-----LEEDLRTARSALKLKNE---EVE 1396
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYK 537
R + +E+ L+ KA+ + +E +++ L E+ ++ K
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQEL-EKQREMQK 1455
Query: 538 SKVDENNANLNL----IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+ ++ + +L + + E+I L+ + E +++ E++ KLT I L++
Sbjct: 1456 AALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK 1515
Query: 594 ENNSLKSL--NDVITREKETQASELERS-CQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
+ + +++ + ++ EK+ Q E +R Q +K+ L+ + ++
Sbjct: 1516 DRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL 1575
Query: 651 XXXXXDEAKS----LLEQNLALKEQCEEKTRDCSRLEINIKTH---------EKTAEI-- 695
+ ++ L L L+E+ +E S++ ++++H E+ E+
Sbjct: 1576 IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKS 1634
Query: 696 QNRMIMRLQKQIQE--------DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESS-R 746
Q I LQ+Q + D +L ++KE ++ L ++ + + ++ ++ S R
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLEQIKLSLR 1693
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
E +LTTQ+ L++ R E + + ++ + E +
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHEL-QELK 1752
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE----RYKELDDECETCA 862
D E R + S +SQ ++ ++ QQ+L + +E + + L + +
Sbjct: 1753 DQLEQQL--QGLHRKVGETS-LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
L +RD++ L++E+ + Q +KE+ Q Q A + + H
Sbjct: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQ---AHMTLKERHGELQDHKE 1866
Query: 923 VVDRMSYDAEVE--KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
R+ + VE + + L + + +LR + ++ + + +Q ++ ++ +E E + +
Sbjct: 1867 QARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ---QQCAEQAQEHEVETRA 1923
Query: 981 LEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQCKRLKEA-KIAL-EIVDKLSNQKV 1037
L+D + + LK+R +EL E ++ + +EE + EA + AL + L ++
Sbjct: 1924 LQDSWLQAQAVLKERDQEL-EALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ 1982
Query: 1038 ALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMK 1075
L +Q E + S +T+ + + ++Q+ + ++
Sbjct: 1983 HLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
Score = 55.6 bits (128), Expect = 9e-07
Identities = 100/507 (19%), Positives = 200/507 (39%), Gaps = 30/507 (5%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
EE +++ L +E +L + V+ + ++ + L +A+ + E L +
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERERLQEMLMGLE 532
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
K +E +S + L+E S +++ +E+ + L R+ Q I + + +K ++
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ L +Q L L+E E CSR+E + +N
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEE---ENQSVCSRMEA-------AEQARNA 642
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + L + + + L+ EK T L K E + A ++D++ +E + QK L
Sbjct: 643 LQVDLAEAEKRREALW-EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI-----QKKL 696
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
E R + + + EQ E R D
Sbjct: 697 SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE 878
++ + S E+ L+ L QQ+ ++ +L+ + +T Q ++ ++
Sbjct: 757 EQLQGLSSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT---QAKEVIQGEVRCL 811
Query: 879 KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD-EDWANLHSVVVDRMSYDAEVEKN- 936
KL L+ + S +++ + RQ A+ T E H V+++ E E++
Sbjct: 812 KLELDTERSQAEQE---RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW 868
Query: 937 --KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
+ L K +E L +K +L+ + + Q ME + +E E + E C+ +LE K+R
Sbjct: 869 HQQELAKALESLEREKMELEMRLKEQQTEMEAI-QAQREEERTQAESALCQMQLETEKER 927
Query: 995 YKELDEECETCAEYLKQREEQCKRLKE 1021
L+ +T E L +Q +RL++
Sbjct: 928 VSLLETLLQTQKE-LADASQQLERLRQ 953
Score = 54.8 bits (126), Expect = 2e-06
Identities = 145/763 (19%), Positives = 317/763 (41%), Gaps = 58/763 (7%)
Query: 66 SSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL-EMENLTKDK 124
S +E +L+L+ FD ++ AL L Q L Q+ E NL + +
Sbjct: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
+ K +++ +L E DTL+ ++ E D+L+KE + L+K E L Q+
Sbjct: 423 H-DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 185 LEK---LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS--DSNTSTRY 239
LE+ + ++ + AQ + KE+ + LH+ +L + ++ S
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQ-KEDQQEELHLAVRER-ERLQEMLMGLEAKQSESL 539
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGENNEFETKAVKV 298
+++ TL+ L++ + + L ++ T + L E ++ + E + + +A V
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599
Query: 299 -MSEIKRNLN----SLSEQLIN----NESKKSK-DHIDRYKDSLLAVL-DAEFGTTSLDV 347
+S + L L++QL+ N+S S+ + ++ +++L L +AE +L
Sbjct: 600 KLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 348 FEILMDNIINK-------YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
++ + K Q DL +I E+ ++Q L+E + ++ +L L+ +
Sbjct: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
Query: 401 KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLP 460
+E +KE + +A+ + + E + ++ L ++ LS K + L +
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQD-LAEQLQGLSSAKELLESSLFEAQQ 778
Query: 461 AHKKITILFDALITQYELSRTDYEI---EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ I + L Q + E+ E L+LE T ++ +
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
Query: 518 L-EEAHNEVKSLHEELTKLYKSKVDENNA-----NLNLIKILSEEIDALKIAIAKNEEKM 571
+ A + K+ HE+ + K ++ + ++ L E L++ + + + +M
Sbjct: 839 EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898
Query: 572 LSL-SEKDNKLTELVSTI--NGLKEENNSLKSLNDVITREKETQ--ASELERSCQVIK-- 624
++ ++++ + T+ S + L+ E + L ++ +KE + +LER Q +K
Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958
Query: 625 ------QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK--- 675
G +++ +E+ SLL+ + L++Q E+
Sbjct: 959 KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQ 1018
Query: 676 --TRDCSRLEINIKTHEKTAEIQ--NRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEAL 731
+D S+ + + EK E Q NR+ L+++ +EKE +L L
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 732 KRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
+++ A +D++ ++ +L+ Q +L+ + E E+D ++
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Score = 52.4 bits (120), Expect = 9e-06
Identities = 55/267 (20%), Positives = 124/267 (46%), Gaps = 8/267 (2%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
RS + + EV +ER + Q++ + + K L + + L ER+E+ L+ +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 880 LSLEQQVSNLKEQIRTQQ-PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
LE+Q K + ++++ + D+ ++ SV+ + + + E+ ++
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL-EHLPMAVQ-EREQK 1502
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
L E++R ++D + ++ + + KKD+ E++R +++D K +L L+ EL
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 999 DE---ECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESL-SNTPVSN 1053
+E + E + +K+ E Q + + A L + +++ S + A QI L S++ V
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKL 1080
+ Q +QI ++ ++ + L
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHL 1649
Score = 49.2 bits (112), Expect = 8e-05
Identities = 58/273 (21%), Positives = 121/273 (44%), Gaps = 12/273 (4%)
Query: 833 LKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
L++++ ++ L D + ++ E + L + E+ ++ + ++ SLE ++ L E
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 893 IRTQQPVERQAKFADVAVNTDEDWA-----NLHSVVVDRMSYDAEVEKNKRLMKTIEE-L 946
+ + Q R+A+ + + + NL + V + E +EE L
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
R + LK +++ E+ ++ E K + + + L L Q E +EE ET
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 1007 EYLKQREEQCKRLKEAKIALEIVDKLSNQKVAL-EKQIESLS--NTPVSNSTMYV--ATG 1061
+++ E+Q + K A L + K NQ+V L ++QI+ L + + + M V
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 1062 SAIVQNQQITDVMKENQKLKK-MNAKLITICKK 1093
VQ +QI ++ K+ + + + +L+ + KK
Sbjct: 1502 KLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534
Score = 45.2 bits (102), Expect = 0.001
Identities = 77/424 (18%), Positives = 160/424 (37%), Gaps = 18/424 (4%)
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
EK A +++ +++L+ Q + ++ T+L+ L + + DY+ +K L + E +
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
T+ E ++ + + + + + +
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Query: 810 ENPKLDDSPK-----RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
D+ K RS+ V L+++L CQ+ ++ L++++ + ++E + +
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR 436
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
LQ+ + L + + L+ +V +L ++ Q + + + V E W L V V
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR-QQLEVLEQEAW-RLRRVNV 494
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ + K + EEL ++ + + K ++ E R+ LE
Sbjct: 495 ELQLQGDSAQGQKEDQQ--EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS 552
Query: 985 KAELEELKQRYKELD---EECETCAEYLKQREEQCKR----LKEAKIALEIVDK-LSNQK 1036
E E L+Q E+ E L E K L+ A + L +++ L+ K
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 1037 VALEKQIESLSNTPVS-NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRG 1095
V L +Q+ L S S M A + + + K + L + N L +K
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 1096 KTGA 1099
+ GA
Sbjct: 673 EAGA 676
Score = 44.0 bits (99), Expect = 0.003
Identities = 171/971 (17%), Positives = 365/971 (37%), Gaps = 79/971 (8%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + E+ + + S EL +K Q + + Q+ + E L + + + +N
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE------LSALLTQSQKQNEDY 302
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK-KNNECLTQK 181
+K IK L ++++ EL E +LS E + K++ + + + + Q
Sbjct: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
Query: 182 CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK 241
L E ++ I + L++S+ + L + ++ +
Sbjct: 363 SGHENSL--ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL-- 418
Query: 242 ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE 301
LQ + D E+ K L + + + T+DL ++ ++ K E
Sbjct: 419 ---LQQQHDQWEEEGKALRQRLQKLTGERDTLA-GQTVDLQGEVDSLSKERELLQKAREE 474
Query: 302 IKRNLNSLSEQL-----INNESKKSKDHI-----DRYKDSLLAVLDAEFGTTSLDVFEIL 351
+++ L L ++ +N E + D D+ ++ LAV + E L E
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERERLQEMLMGLEAK 534
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDL-----NECTSELKSVNEKLASLNSQLIEKENACN 406
+++ I L E LE + ++G+L E T+ L + +A L+S +
Sbjct: 535 QSESLSEL-ITLREALES-SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI--DIPRDLDQDLP-AHK 463
LR ++ ++ A+ +D V +L ++ + S+++ L DL A K
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652
Query: 464 KITILFDA---LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
+ L++ L Q + + + LR + + LE+
Sbjct: 653 RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ 712
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
H E K E L + + K + L E AL++ + E L+E+
Sbjct: 713 LHQEAKRQEEVLARAVQEK-----------EALVREKAALEVRLQAVERDRQDLAEQLQG 761
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI--L 638
L+ + E S+ +V + E Q + ++ +VI Q K++ D
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI-QGEVRCLKLELDTERS 820
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
E K+ LEQ A E+ E+N + EK + ++
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEK-----------EVN-QLREKWEKERSW 868
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
L K ++ ++ +E E +L E + EA++ + ES+ + QL T+K+
Sbjct: 869 HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM-QLETEKE- 926
Query: 759 VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-LDDS 817
R++ LE+ ++T++ T G L E + L ++
Sbjct: 927 ---RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA 983
Query: 818 PKRSISVIS--DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
++ ++ E S L + + Q++++DLK + DD + +QE+ +
Sbjct: 984 ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+ + LE++ ++L + ++ +R + ++ + L + + E+
Sbjct: 1044 NRIQKELEREKASLTLSLMEKE--QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
L++ +E++ K+ D ++ + +E +++ R L +A+ +L+ R
Sbjct: 1102 QMELLR--QEVKEKEADFLAQEAQLLEELEASHITEQQL---RASLWAQEAKAAQLQLRL 1156
Query: 996 KELDEECETCA 1006
+ + + E A
Sbjct: 1157 RSTESQLEALA 1167
Score = 41.5 bits (93), Expect = 0.016
Identities = 31/120 (25%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Query: 33 KNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKE-QKSAL 91
K D +IE+Q ++ +T+ C + L+E+ +++ + +KL EL +E Q+ AL
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLEC-LALELEENHHKMECQ-QKLIKELEGQRETQRVAL 1590
Query: 92 EGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLS 151
+L +Q SQI LE + +E++ +K++ ++I ELQ + + L+
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
>BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 70.5 bits (165), Expect = 3e-11
Identities = 155/838 (18%), Positives = 333/838 (39%), Gaps = 47/838 (5%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K LE E + I+ SL +SKK E++ TL T D+ K++
Sbjct: 469 KVLETEGSQESTVIR--APSLGAQSKKEEEVKTATATLMLQNRAAATSPDSGAKKISVKT 526
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ TQ DL K G + + Q E + + Y S N +
Sbjct: 527 FPSASNTQATPDLLK---------GQQELTQQTN--EETAKQILYNYLKEGSTDNDDATK 575
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + KI TL+S + + C + +K+ LE + +T+++ E L + E
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAE-LQRQLQLE 633
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
K + + E + + + E+L + ++K +++ + L + E ++F++ M
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKM 691
Query: 353 DNIINKYQI-DL-DEILEKYTKVQGDLNECTSELKSVNEKLAS----LNSQLIEKENACN 406
+ ++ +I DL D++ E + ++ E ++ E+L L LI KE +
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKI 465
+LR ++ + + A+ ++ + E+ ++ + +L L+ + ++ A +
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
T D T+ + E EK + R E + + +TL++
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E++ L E L K + + +A + L E++A + +++ ++ LSEK + +E
Sbjct: 872 EIRQLEEALVHARKEEKEAVSAR----RALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927
Query: 584 LVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ LK E N L I + ++ A +E S + +LD+ K
Sbjct: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI-- 700
++++ + EE+ RD R + T + E + +
Sbjct: 988 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
Query: 701 -MRLQKQIQED-DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + +++D +L + E K+++L + E + + D + + SRE + QL + +L
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQL--RNEL 1105
Query: 759 VEGRIA--ELESD-IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R A +LE D I E+ +L + + +
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + + ++KE ++ E L ++ +L + ++E +E+ RL
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+ K L+++ L+EQ+ + ++ Q ++ D L S V+D M D ++
Sbjct: 1226 ESSKKKLQRE---LEEQMDMNEHLQGQLN----SMKKDLRLKKLPSKVLDDMDDDDDL 1276
Score = 63.3 bits (147), Expect = 5e-09
Identities = 125/567 (22%), Positives = 244/567 (43%), Gaps = 57/567 (10%)
Query: 519 EEAHNEVKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKM 571
EE + ++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E +
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 572 LS---LSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQ 621
S SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ +
Sbjct: 807 ASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 622 VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRD 678
+K+ E+ +++ ++ +E A+ L Q ++Q EK ++
Sbjct: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDA 737
S + ++ + E + + + +++Q++ +E T EL N+ + K
Sbjct: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
Query: 738 AVKDL-----ESSREAV-NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
+ ++ E + EA ++LT K E R+ +E ++R Q A
Sbjct: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL--MEEELRDYQRAQ----------DEAL 1032
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
T D +L L D R + + D +VSQL+ L + D L ER
Sbjct: 1033 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLSERI 1091
Query: 852 KELDDECETCA-EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
++ E E LQER + L+ +K+SLE+Q +LK +I + R +K + V
Sbjct: 1092 SRSREQMEQLRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSYRSSK-EGLVV 1149
Query: 911 NTDEDWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ A L + A ++ N+RL + ++EL + D ++T + + K
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK 1209
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIA 1025
A ++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+
Sbjct: 1210 ------AMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP 1263
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVS 1052
+++D + + L SL PVS
Sbjct: 1264 SKVLDDMDDDD-DLSTDGGSLYEAPVS 1289
Score = 62.5 bits (145), Expect = 8e-09
Identities = 147/742 (19%), Positives = 305/742 (41%), Gaps = 55/742 (7%)
Query: 25 NQLDGAKSKNDNIIETQSN-PIKLQD-SGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
NQ + S+ +++E +S I++ + + + K Q++KE + LE+L +
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E+ S L+ + + E + R L ++ ++ME EI++L D L +++
Sbjct: 660 EKVEENSTLQQRLEES--EGELRKNL-EELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI-DLEKLVNESENKIGPKNI 201
+ D ++E + ++ +++ K+ E L +K +L L + ++ +
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD-AGRE-DCKEL 259
KLKE YD L L S+ ++ + + SE D AG E K L
Sbjct: 777 -EMDKLKEQ--------YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E+ ++ E E + L ++ + E KA + + + + + L E L++ K
Sbjct: 828 QEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-K 885
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K+ + + +L L+A G S E + K + + ++ E+ +++ ++
Sbjct: 886 EEKEAVSARR-ALENELEAAQGNLSQTTQE--QKQLSEKLKEESEQ-KEQLRRLKNEMEN 941
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE-ILT 438
L EKL + ++E + L +Q + + E ++ + + +LKE L
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 439 KECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLETG 495
E +L+ +K+ D R ++++L +++ L + + L +YE+E K L+
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDD 1058
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
++ V LEE N L E +++ + ++++ L + +
Sbjct: 1059 RSRLVKQMEDKVSQLEME----LEEERNNSDLLSERISRS-REQMEQLRNELLQERAARQ 1113
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+++ KI++ + + + S ++ L + KE L + E E +
Sbjct: 1114 DLECDKISLERQNKDLKS------RIIHLEGSYRSSKE---GLVVQMEARIAELEDRLES 1164
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
ER ++ + L++ +++M D+ L + A+K Q EE
Sbjct: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEHLSLT------DQKDQLSLRLKAMKRQVEEA 1218
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ RLE + K ++ E Q M LQ Q+ ++K+ +L +L +K D
Sbjct: 1219 EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS-----MKKDLRLKKLPSKVLDDMDDD 1273
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
D D S EA T KD
Sbjct: 1274 DDLSTDGGSLYEAPVSYTFSKD 1295
Score = 59.3 bits (137), Expect = 8e-08
Identities = 99/448 (22%), Positives = 194/448 (43%), Gaps = 58/448 (12%)
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
NL ++ K+R + N + T+E+++ + + + I+ + ++++ +L E+
Sbjct: 579 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQL-EV 634
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
N+ + +K + + +LE R N+ + ++ R+ E E ++R
Sbjct: 635 KNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
DE DS KRS D E L E LL +Q+L
Sbjct: 694 EQHQTEIRDLQDQLSEMHDEL----------DSAKRS----EDREKGALIEELLQAKQDL 739
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLK---KEKLSL-EQQVSNLKEQIRTQ---- 896
DL +E +D L++R+ + LK KE++S +Q++ LKEQ +
Sbjct: 740 QDLLIAKEEQED-------LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 897 -QPVERQAKFADVAV---NTDE-DWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKK 950
+ VE K +V NT E D A V + +++ +++ L + + +L+ +
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFE-----AKRKELEDCKA------ELEELKQRYKELD 999
+DLK K ++ ++KY + ++ E A+++E E A ELE + +
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+E + +E LK+ EQ ++L+ K +++ N++ L K IE L +++
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLK------NEMENERWHLGKTIEKLQK-EMADIVEASR 965
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
T + +QNQ K ++L +M +L
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQL 993
Score = 57.2 bits (132), Expect = 3e-07
Identities = 116/561 (20%), Positives = 226/561 (40%), Gaps = 37/561 (6%)
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
+EVK L E+ +KL +V E L L + I + + N E++ S + + K+
Sbjct: 607 SEVKDLLEQKSKL-TIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS--QHNEKVE 663
Query: 583 ELVSTINGLKEENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E + L+E L K+L ++ + E + + E I+ +L +M ++
Sbjct: 664 ENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTE-----IRDLQDQLSEMHDELDSAK 718
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+AK L+ L KE+ E+ R R +K K + M
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
K+ Q D +L +E+ + E T E L + + +D + V L + + ++G
Sbjct: 779 DKLKE-QYDAELQALRES-VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQG 836
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
R ELE + Q + + K S +R+
Sbjct: 837 RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA 896
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ ++E+ + L QE L E+ KE ++ E E + + L K
Sbjct: 897 L----ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLM 940
L+++++++ E RT +E Q + + + A + + ++ E EK++ M
Sbjct: 953 LQKEMADIVEASRTST-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAM 1008
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAEL----- 988
K +E+R +++L++ +A+ K T KD E+E AK L+D ++ L
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQME 1067
Query: 989 EELKQRYKELDEE---CETCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIE 1044
+++ Q EL+EE + +E + + EQ ++L+ + L K++LE+Q +
Sbjct: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 1045 SLSNTPVSNSTMYVATGSAIV 1065
L + + Y ++ +V
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLV 1148
>BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 70.5 bits (165), Expect = 3e-11
Identities = 155/838 (18%), Positives = 333/838 (39%), Gaps = 47/838 (5%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K LE E + I+ SL +SKK E++ TL T D+ K++
Sbjct: 469 KVLETEGSQESTVIR--APSLGAQSKKEEEVKTATATLMLQNRAAATSPDSGAKKISVKT 526
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ TQ DL K G + + Q E + + Y S N +
Sbjct: 527 FPSASNTQATPDLLK---------GQQELTQQTN--EETAKQILYNYLKEGSTDNDDATK 575
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + KI TL+S + + C + +K+ LE + +T+++ E L + E
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAE-LQRQLQLE 633
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
K + + E + + + E+L + ++K +++ + L + E ++F++ M
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKM 691
Query: 353 DNIINKYQI-DL-DEILEKYTKVQGDLNECTSELKSVNEKLAS----LNSQLIEKENACN 406
+ ++ +I DL D++ E + ++ E ++ E+L L LI KE +
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKI 465
+LR ++ + + A+ ++ + E+ ++ + +L L+ + ++ A +
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
T D T+ + E EK + R E + + +TL++
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E++ L E L K + + +A + L E++A + +++ ++ LSEK + +E
Sbjct: 872 EIRQLEEALVHARKEEKEAVSAR----RALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927
Query: 584 LVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ LK E N L I + ++ A +E S + +LD+ K
Sbjct: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI-- 700
++++ + EE+ RD R + T + E + +
Sbjct: 988 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
Query: 701 -MRLQKQIQED-DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + +++D +L + E K+++L + E + + D + + SRE + QL + +L
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQL--RNEL 1105
Query: 759 VEGRIA--ELESD-IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R A +LE D I E+ +L + + +
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + + ++KE ++ E L ++ +L + ++E +E+ RL
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+ K L+++ L+EQ+ + ++ Q ++ D L S V+D M D ++
Sbjct: 1226 ESSKKKLQRE---LEEQMDMNEHLQGQLN----SMKKDLRLKKLPSKVLDDMDDDDDL 1276
Score = 63.3 bits (147), Expect = 5e-09
Identities = 125/567 (22%), Positives = 244/567 (43%), Gaps = 57/567 (10%)
Query: 519 EEAHNEVKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKM 571
EE + ++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E +
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 572 LS---LSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQ 621
S SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ +
Sbjct: 807 ASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 622 VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRD 678
+K+ E+ +++ ++ +E A+ L Q ++Q EK ++
Sbjct: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDA 737
S + ++ + E + + + +++Q++ +E T EL N+ + K
Sbjct: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
Query: 738 AVKDL-----ESSREAV-NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
+ ++ E + EA ++LT K E R+ +E ++R Q A
Sbjct: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL--MEEELRDYQRAQ----------DEAL 1032
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
T D +L L D R + + D +VSQL+ L + D L ER
Sbjct: 1033 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLSERI 1091
Query: 852 KELDDECETCA-EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
++ E E LQER + L+ +K+SLE+Q +LK +I + R +K + V
Sbjct: 1092 SRSREQMEQLRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSYRSSK-EGLVV 1149
Query: 911 NTDEDWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ A L + A ++ N+RL + ++EL + D ++T + + K
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK 1209
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIA 1025
A ++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+
Sbjct: 1210 ------AMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP 1263
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVS 1052
+++D + + L SL PVS
Sbjct: 1264 SKVLDDMDDDD-DLSTDGGSLYEAPVS 1289
Score = 62.5 bits (145), Expect = 8e-09
Identities = 147/742 (19%), Positives = 305/742 (41%), Gaps = 55/742 (7%)
Query: 25 NQLDGAKSKNDNIIETQSN-PIKLQD-SGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
NQ + S+ +++E +S I++ + + + K Q++KE + LE+L +
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E+ S L+ + + E + R L ++ ++ME EI++L D L +++
Sbjct: 660 EKVEENSTLQQRLEES--EGELRKNL-EELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI-DLEKLVNESENKIGPKNI 201
+ D ++E + ++ +++ K+ E L +K +L L + ++ +
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD-AGRE-DCKEL 259
KLKE YD L L S+ ++ + + SE D AG E K L
Sbjct: 777 -EMDKLKEQ--------YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E+ ++ E E + L ++ + E KA + + + + + L E L++ K
Sbjct: 828 QEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-K 885
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K+ + + +L L+A G S E + K + + ++ E+ +++ ++
Sbjct: 886 EEKEAVSARR-ALENELEAAQGNLSQTTQE--QKQLSEKLKEESEQ-KEQLRRLKNEMEN 941
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE-ILT 438
L EKL + ++E + L +Q + + E ++ + + +LKE L
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 439 KECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLETG 495
E +L+ +K+ D R ++++L +++ L + + L +YE+E K L+
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDD 1058
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
++ V LEE N L E +++ + ++++ L + +
Sbjct: 1059 RSRLVKQMEDKVSQLEME----LEEERNNSDLLSERISRS-REQMEQLRNELLQERAARQ 1113
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+++ KI++ + + + S ++ L + KE L + E E +
Sbjct: 1114 DLECDKISLERQNKDLKS------RIIHLEGSYRSSKE---GLVVQMEARIAELEDRLES 1164
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
ER ++ + L++ +++M D+ L + A+K Q EE
Sbjct: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEHLSLT------DQKDQLSLRLKAMKRQVEEA 1218
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ RLE + K ++ E Q M LQ Q+ ++K+ +L +L +K D
Sbjct: 1219 EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS-----MKKDLRLKKLPSKVLDDMDDD 1273
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
D D S EA T KD
Sbjct: 1274 DDLSTDGGSLYEAPVSYTFSKD 1295
Score = 59.3 bits (137), Expect = 8e-08
Identities = 99/448 (22%), Positives = 194/448 (43%), Gaps = 58/448 (12%)
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
NL ++ K+R + N + T+E+++ + + + I+ + ++++ +L E+
Sbjct: 579 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQL-EV 634
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
N+ + +K + + +LE R N+ + ++ R+ E E ++R
Sbjct: 635 KNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
DE DS KRS D E L E LL +Q+L
Sbjct: 694 EQHQTEIRDLQDQLSEMHDEL----------DSAKRS----EDREKGALIEELLQAKQDL 739
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLK---KEKLSL-EQQVSNLKEQIRTQ---- 896
DL +E +D L++R+ + LK KE++S +Q++ LKEQ +
Sbjct: 740 QDLLIAKEEQED-------LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 897 -QPVERQAKFADVAV---NTDE-DWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKK 950
+ VE K +V NT E D A V + +++ +++ L + + +L+ +
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFE-----AKRKELEDCKA------ELEELKQRYKELD 999
+DLK K ++ ++KY + ++ E A+++E E A ELE + +
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+E + +E LK+ EQ ++L+ K +++ N++ L K IE L +++
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLK------NEMENERWHLGKTIEKLQK-EMADIVEASR 965
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
T + +QNQ K ++L +M +L
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQL 993
Score = 57.2 bits (132), Expect = 3e-07
Identities = 116/561 (20%), Positives = 226/561 (40%), Gaps = 37/561 (6%)
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
+EVK L E+ +KL +V E L L + I + + N E++ S + + K+
Sbjct: 607 SEVKDLLEQKSKL-TIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS--QHNEKVE 663
Query: 583 ELVSTINGLKEENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E + L+E L K+L ++ + E + + E I+ +L +M ++
Sbjct: 664 ENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTE-----IRDLQDQLSEMHDELDSAK 718
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+AK L+ L KE+ E+ R R +K K + M
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
K+ Q D +L +E+ + E T E L + + +D + V L + + ++G
Sbjct: 779 DKLKE-QYDAELQALRES-VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQG 836
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
R ELE + Q + + K S +R+
Sbjct: 837 RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA 896
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ ++E+ + L QE L E+ KE ++ E E + + L K
Sbjct: 897 L----ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLM 940
L+++++++ E RT +E Q + + + A + + ++ E EK++ M
Sbjct: 953 LQKEMADIVEASRTST-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAM 1008
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAEL----- 988
K +E+R +++L++ +A+ K T KD E+E AK L+D ++ L
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQME 1067
Query: 989 EELKQRYKELDEE---CETCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIE 1044
+++ Q EL+EE + +E + + EQ ++L+ + L K++LE+Q +
Sbjct: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 1045 SLSNTPVSNSTMYVATGSAIV 1065
L + + Y ++ +V
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLV 1148
>BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 70.5 bits (165), Expect = 3e-11
Identities = 155/838 (18%), Positives = 333/838 (39%), Gaps = 47/838 (5%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K LE E + I+ SL +SKK E++ TL T D+ K++
Sbjct: 469 KVLETEGSQESTVIR--APSLGAQSKKEEEVKTATATLMLQNRAAATSPDSGAKKISVKT 526
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ TQ DL K G + + Q E + + Y S N +
Sbjct: 527 FPSASNTQATPDLLK---------GQQELTQQTN--EETAKQILYNYLKEGSTDNDDATK 575
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + KI TL+S + + C + +K+ LE + +T+++ E L + E
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAE-LQRQLQLE 633
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
K + + E + + + E+L + ++K +++ + L + E ++F++ M
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKM 691
Query: 353 DNIINKYQI-DL-DEILEKYTKVQGDLNECTSELKSVNEKLAS----LNSQLIEKENACN 406
+ ++ +I DL D++ E + ++ E ++ E+L L LI KE +
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKI 465
+LR ++ + + A+ ++ + E+ ++ + +L L+ + ++ A +
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
T D T+ + E EK + R E + + +TL++
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E++ L E L K + + +A + L E++A + +++ ++ LSEK + +E
Sbjct: 872 EIRQLEEALVHARKEEKEAVSAR----RALENELEAAQGNLSQTTQEQKQLSEKLKEESE 927
Query: 584 LVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ LK E N L I + ++ A +E S + +LD+ K
Sbjct: 928 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 987
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI-- 700
++++ + EE+ RD R + T + E + +
Sbjct: 988 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 1047
Query: 701 -MRLQKQIQED-DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + +++D +L + E K+++L + E + + D + + SRE + QL + +L
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQL--RNEL 1105
Query: 759 VEGRIA--ELESD-IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R A +LE D I E+ +L + + +
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + + ++KE ++ E L ++ +L + ++E +E+ RL
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+ K L+++ L+EQ+ + ++ Q ++ D L S V+D M D ++
Sbjct: 1226 ESSKKKLQRE---LEEQMDMNEHLQGQLN----SMKKDLRLKKLPSKVLDDMDDDDDL 1276
Score = 63.3 bits (147), Expect = 5e-09
Identities = 125/567 (22%), Positives = 244/567 (43%), Gaps = 57/567 (10%)
Query: 519 EEAHNEVKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKM 571
EE + ++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E +
Sbjct: 747 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 572 LS---LSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQ 621
S SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ +
Sbjct: 807 ASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 622 VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRD 678
+K+ E+ +++ ++ +E A+ L Q ++Q EK ++
Sbjct: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDA 737
S + ++ + E + + + +++Q++ +E T EL N+ + K
Sbjct: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
Query: 738 AVKDL-----ESSREAV-NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
+ ++ E + EA ++LT K E R+ +E ++R Q A
Sbjct: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL--MEEELRDYQRAQ----------DEAL 1032
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
T D +L L D R + + D +VSQL+ L + D L ER
Sbjct: 1033 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLSERI 1091
Query: 852 KELDDECETCA-EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
++ E E LQER + L+ +K+SLE+Q +LK +I + R +K + V
Sbjct: 1092 SRSREQMEQLRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSYRSSK-EGLVV 1149
Query: 911 NTDEDWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ A L + A ++ N+RL + ++EL + D ++T + + K
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK 1209
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIA 1025
A ++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+
Sbjct: 1210 ------AMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP 1263
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVS 1052
+++D + + L SL PVS
Sbjct: 1264 SKVLDDMDDDD-DLSTDGGSLYEAPVS 1289
Score = 62.5 bits (145), Expect = 8e-09
Identities = 147/742 (19%), Positives = 305/742 (41%), Gaps = 55/742 (7%)
Query: 25 NQLDGAKSKNDNIIETQSN-PIKLQD-SGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
NQ + S+ +++E +S I++ + + + K Q++KE + LE+L +
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E+ S L+ + + E + R L ++ ++ME EI++L D L +++
Sbjct: 660 EKVEENSTLQQRLEES--EGELRKNL-EELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI-DLEKLVNESENKIGPKNI 201
+ D ++E + ++ +++ K+ E L +K +L L + ++ +
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD-AGRE-DCKEL 259
KLKE YD L L S+ ++ + + SE D AG E K L
Sbjct: 777 -EMDKLKEQ--------YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E+ ++ E E + L ++ + E KA + + + + + L E L++ K
Sbjct: 828 QEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-K 885
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K+ + + +L L+A G S E + K + + ++ E+ +++ ++
Sbjct: 886 EEKEAVSARR-ALENELEAAQGNLSQTTQE--QKQLSEKLKEESEQ-KEQLRRLKNEMEN 941
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE-ILT 438
L EKL + ++E + L +Q + + E ++ + + +LKE L
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 439 KECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLETG 495
E +L+ +K+ D R ++++L +++ L + + L +YE+E K L+
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDD 1058
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
++ V LEE N L E +++ + ++++ L + +
Sbjct: 1059 RSRLVKQMEDKVSQLEME----LEEERNNSDLLSERISRS-REQMEQLRNELLQERAARQ 1113
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+++ KI++ + + + S ++ L + KE L + E E +
Sbjct: 1114 DLECDKISLERQNKDLKS------RIIHLEGSYRSSKE---GLVVQMEARIAELEDRLES 1164
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
ER ++ + L++ +++M D+ L + A+K Q EE
Sbjct: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEHLSLT------DQKDQLSLRLKAMKRQVEEA 1218
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ RLE + K ++ E Q M LQ Q+ ++K+ +L +L +K D
Sbjct: 1219 EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS-----MKKDLRLKKLPSKVLDDMDDD 1273
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
D D S EA T KD
Sbjct: 1274 DDLSTDGGSLYEAPVSYTFSKD 1295
Score = 59.3 bits (137), Expect = 8e-08
Identities = 99/448 (22%), Positives = 194/448 (43%), Gaps = 58/448 (12%)
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
NL ++ K+R + N + T+E+++ + + + I+ + ++++ +L E+
Sbjct: 579 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQL-EV 634
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
N+ + +K + + +LE R N+ + ++ R+ E E ++R
Sbjct: 635 KNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
DE DS KRS D E L E LL +Q+L
Sbjct: 694 EQHQTEIRDLQDQLSEMHDEL----------DSAKRS----EDREKGALIEELLQAKQDL 739
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLK---KEKLSL-EQQVSNLKEQIRTQ---- 896
DL +E +D L++R+ + LK KE++S +Q++ LKEQ +
Sbjct: 740 QDLLIAKEEQED-------LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 897 -QPVERQAKFADVAV---NTDE-DWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKK 950
+ VE K +V NT E D A V + +++ +++ L + + +L+ +
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFE-----AKRKELEDCKA------ELEELKQRYKELD 999
+DLK K ++ ++KY + ++ E A+++E E A ELE + +
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+E + +E LK+ EQ ++L+ K +++ N++ L K IE L +++
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLK------NEMENERWHLGKTIEKLQK-EMADIVEASR 965
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
T + +QNQ K ++L +M +L
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQL 993
Score = 57.2 bits (132), Expect = 3e-07
Identities = 116/561 (20%), Positives = 226/561 (40%), Gaps = 37/561 (6%)
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
+EVK L E+ +KL +V E L L + I + + N E++ S + + K+
Sbjct: 607 SEVKDLLEQKSKL-TIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS--QHNEKVE 663
Query: 583 ELVSTINGLKEENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E + L+E L K+L ++ + E + + E I+ +L +M ++
Sbjct: 664 ENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTE-----IRDLQDQLSEMHDELDSAK 718
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+AK L+ L KE+ E+ R R +K K + M
Sbjct: 719 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
K+ Q D +L +E+ + E T E L + + +D + V L + + ++G
Sbjct: 779 DKLKE-QYDAELQALRES-VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQG 836
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
R ELE + Q + + K S +R+
Sbjct: 837 RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA 896
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ ++E+ + L QE L E+ KE ++ E E + + L K
Sbjct: 897 L----ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLM 940
L+++++++ E RT +E Q + + + A + + ++ E EK++ M
Sbjct: 953 LQKEMADIVEASRTST-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAM 1008
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAEL----- 988
K +E+R +++L++ +A+ K T KD E+E AK L+D ++ L
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQME 1067
Query: 989 EELKQRYKELDEE---CETCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIE 1044
+++ Q EL+EE + +E + + EQ ++L+ + L K++LE+Q +
Sbjct: 1068 DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 1045 SLSNTPVSNSTMYVATGSAIV 1065
L + + Y ++ +V
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLV 1148
>AY739715-1|AAW65984.1| 617|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 617
Score = 70.5 bits (165), Expect = 3e-11
Identities = 77/335 (22%), Positives = 147/335 (43%), Gaps = 19/335 (5%)
Query: 708 QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
+ D L EKET + +L + + D ++ + + A+++LT + +I ELE
Sbjct: 3 KNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE 62
Query: 768 SDIRT---EQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV 824
+ + T E++ + F + +D +N K D + + +
Sbjct: 63 TILETQKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK--DLNVKELKL 120
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKELD-DECETCAEYLQERDEQCARLKKEKLSLE 883
E++QL L + L LKE +E + E E E L + LK + E
Sbjct: 121 --KEEITQLTNNLQDMKHLLQ-LKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKE 177
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-- 941
+ ++LKE++ + +Q + +V+V DED L + ++ + + MK
Sbjct: 178 EDYADLKEKLTDAKKQIKQVQ-KEVSVMRDED--KLLRIKINELEKKKNQCSQELDMKQR 234
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
TI++L K+ L N K+++A+++Y + K+ K K +ED + LEE +Q E D+
Sbjct: 235 TIQQL---KEQLNNQ--KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV 289
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
E E +++ + ++ KE LE + + K
Sbjct: 290 LEAKLEEVERLATELEKWKEKCNDLETKNNQRSNK 324
Score = 52.0 bits (119), Expect = 1e-05
Identities = 98/460 (21%), Positives = 195/460 (42%), Gaps = 48/460 (10%)
Query: 30 AKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKS 89
AK + D I+E +S +KL+ + + + Q +++ ++N+K KL E+ +
Sbjct: 76 AKLEQD-ILEKESIILKLERN--LKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNN-- 130
Query: 90 ALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDT 149
L+ L L+ + + + + L+ E +NL L+ K + +L+E+
Sbjct: 131 -LQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTD 189
Query: 150 LSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKE 209
I + + KEV ++ ++ L K +LEK N+ ++ K Q +LKE
Sbjct: 190 AKKQIKQ-------VQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQ-QLKE 241
Query: 210 NLIQSLHIGYDNTLSKLNRSISDSNTSTRY--NKICTLQSELDAGREDCKEL---CEDFT 264
L + + + R+ D N + + TL+ + E + L E+
Sbjct: 242 QLNNQ---KVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVE 298
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDH 324
+ LE + DL+ K NN+ K + +++ L +L ++L +E K + D
Sbjct: 299 RLATELEKWKEKCN-DLETK---NNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADR 354
Query: 325 IDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSEL 384
++ ++ + A+ +NI NK E E++ K Q ++ T++L
Sbjct: 355 KKWLEEKMMLITQAKEA-----------ENIRNKEMKKYAEDRERFFKQQNEMEILTAQL 403
Query: 385 KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
EK + L E++ L IQ + + ISS V+K+NE+++ L + +
Sbjct: 404 ---TEKDSDLQKWREERDQLVAALEIQLKAL--ISSN-----VQKDNEIEQ-LKRIISET 452
Query: 445 SKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
SK++ I + + + + + L T +E+SR E
Sbjct: 453 SKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIE 492
Score = 51.6 bits (118), Expect = 2e-05
Identities = 86/443 (19%), Positives = 177/443 (39%), Gaps = 50/443 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEIN-IKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
+ + ++E AL E + T C + +I ++T +T +++ +L++ I E + + +
Sbjct: 33 QIQHVVEGKRALSELTQGVT--CYKAKIKELETILETQKVERSHSAKLEQDILEKESIIL 90
Query: 716 EKETKLNELTNKYE-ALKRDYDAAVKDLESSREAV---NQLTTQKDLVEGRIAELESDIR 771
+ E L E + ++K D VK+L+ E N L K L++ + E E++ +
Sbjct: 91 KLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQ 150
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE-- 829
+ + D L + K ++ +SV+ D +
Sbjct: 151 ETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKL 210
Query: 830 ----VSQLKERLLSCQQELDDLKERYKELDDEC--ETCAEYLQERDEQCARLKKEKLSLE 883
+++L+++ C QELD + ++L ++ + E +Q+ + C L ++ +E
Sbjct: 211 LRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIE 270
Query: 884 QQVSNLKEQIRTQ-----------QPVERQA--------KFADVAVNTDEDWANLHSVVV 924
L+EQ +TQ + VER A K D+ ++ H
Sbjct: 271 DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNT 330
Query: 925 DRMS---------YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
D + ++E + N K +EE K K M+KY + + F
Sbjct: 331 DVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFF 390
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI----ALEIVDK 1031
++ E+E A+L E ++ EE + L E Q K L + + +E + +
Sbjct: 391 KQQNEMEILTAQLTEKDSDLQKWREERDQLVAAL---EIQLKALISSNVQKDNEIEQLKR 447
Query: 1032 LSNQKVALEKQIESLSNTPVSNS 1054
+ ++ +E QI + +S++
Sbjct: 448 IISETSKIETQIMDIKPKRISSA 470
Score = 41.5 bits (93), Expect = 0.016
Identities = 77/457 (16%), Positives = 177/457 (38%), Gaps = 35/457 (7%)
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
KL + +++ + L L + L E + L+ ++ ++ L+ K+ KL E ++ + +
Sbjct: 77 KLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKD----LNVKELKLKEEITQLTNNLQ 132
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ L L + E+ET E E+ + + + +KAD+
Sbjct: 133 DMKHLLQLKE---EEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTD 189
Query: 654 XXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKL 713
+ K + ++ ++++ + + LE + +++ R I +L++Q+
Sbjct: 190 AKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQ--- 246
Query: 714 FIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
K+ E +YE +D + K +E R + + Q + + ++ E + + E
Sbjct: 247 ------KVEEAIQQYERACKDLNVKEKIIEDMRMTLEE-QEQTQVEQDQVLEAKLE-EVE 298
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
+ AT + LG+ L D + S + L
Sbjct: 299 RLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWL 358
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+E+++ Q + R KE+ +Y ++R+ R K++ +E + L E+
Sbjct: 359 EEKMMLITQAKEAENIRNKEM-------KKYAEDRE----RFFKQQNEMEILTAQLTEK- 406
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDL 953
+++ + D V E L +++ + D E+E+ KR++ ++ + D+
Sbjct: 407 --DSDLQKWREERDQLVAALE--IQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDI 462
Query: 954 K-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
K ++ + FE R ++ED L+
Sbjct: 463 KPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD 499
Score = 35.9 bits (79), Expect = 0.80
Identities = 59/237 (24%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKY-QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTD 131
++E+L+ EL KE+ + LE K Q E + ++ ++ +L+ E ++ E K D
Sbjct: 296 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE--LQESEQKYNAD 353
Query: 132 SLKTKSKKINELQE--ENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKL 188
K +K+ + + E + + N M+ E + K+ ++++ LT+K DL+K
Sbjct: 354 RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKW 413
Query: 189 VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNTSTRYNKICTLQ- 246
E + + I +LK LI S ++ DN + +L R IS+ S T+ I +
Sbjct: 414 REERDQLVAALEI----QLKA-LISS-NVQKDNEIEQLKRIISETSKIETQIMDIKPKRI 467
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
S D + + L F +N +E + ++ +D E EN++ T+ K EI+
Sbjct: 468 SSADPDKLQTEPLSTSFEISRNKIE--DGSVVLDSCEVSTENDQ-STRFPKPELEIQ 521
>AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein.
Length = 1047
Score = 69.3 bits (162), Expect = 7e-11
Identities = 154/838 (18%), Positives = 333/838 (39%), Gaps = 47/838 (5%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K LE E + I+ SL +SKK E++ TL T D+ K++
Sbjct: 214 KVLETEGSQESTVIR--APSLGAQSKKEEEVKTATATLMLQNRAAATSPDSGAKKISVKT 271
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ TQ DL K G + + Q E + + Y S N +
Sbjct: 272 FPSASNTQATPDLLK---------GQQELTQQTN--EETAKQILYNYLKEGSTDNDDATK 320
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + KI TL+S + + C + +K+ LE + +T+++ E L + E
Sbjct: 321 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAE-LQRQLQLE 378
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
K + + E + + + E+L + ++K +++ + L + E ++F++ M
Sbjct: 379 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKM 436
Query: 353 DNIINKYQI-DL-DEILEKYTKVQGDLNECTSELKSVNEKLAS----LNSQLIEKENACN 406
+ ++ +I DL D++ E + ++ E ++ E+L L LI KE +
Sbjct: 437 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 496
Query: 407 ILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ-DLPAHKKI 465
+LR ++ + + A+ ++ + E+ ++ + +L L+ + ++ A +
Sbjct: 497 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 556
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHN 523
T D T+ + E EK + R E + + +TL++
Sbjct: 557 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 616
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E++ L E L K + + +A + L E++A + +++ ++ LSEK + +E
Sbjct: 617 EIRQLEEALVHARKEEKEAVSAR----RALENELEAAQGNLSQTTQEQKQLSEKLKEESE 672
Query: 584 LVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ LK E N L I + ++ A +E S + +LD+ K
Sbjct: 673 QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA 732
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI-- 700
++++ + EE+ RD R + T + E + +
Sbjct: 733 EMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEY 792
Query: 701 -MRLQKQIQED-DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ + +++D +L + E K+++L + E + + D + + SRE + Q+ + +L
Sbjct: 793 ELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQV--RNEL 850
Query: 759 VEGRIA--ELESD-IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R A +LE D I E+ +L + + +
Sbjct: 851 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 910
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ + ++ + + ++KE ++ E L ++ +L + ++E +E+ RL
Sbjct: 911 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 970
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+ K L+++ L+EQ+ + ++ Q ++ D L S V+D M D ++
Sbjct: 971 ESSKKKLQRE---LEEQMDMNEHLQGQLN----SMKKDLRLKKLPSKVLDDMDDDDDL 1021
Score = 63.3 bits (147), Expect = 5e-09
Identities = 125/567 (22%), Positives = 244/567 (43%), Gaps = 57/567 (10%)
Query: 519 EEAHNEVKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKM 571
EE + ++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E +
Sbjct: 492 EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 551
Query: 572 LS---LSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQ 621
S SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ +
Sbjct: 552 ASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 609
Query: 622 VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRD 678
+K+ E+ +++ ++ +E A+ L Q ++Q EK ++
Sbjct: 610 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 669
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDA 737
S + ++ + E + + + +++Q++ +E T EL N+ + K
Sbjct: 670 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 729
Query: 738 AVKDL-----ESSREAV-NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
+ ++ E + EA ++LT K E R+ +E ++R Q A
Sbjct: 730 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL--MEEELRDYQRAQ----------DEAL 777
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
T D +L L D R + + D +VSQL+ L + D L ER
Sbjct: 778 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLSERI 836
Query: 852 KELDDECETCA-EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
++ E E LQER + L+ +K+SLE+Q +LK +I + R +K + V
Sbjct: 837 SRSREQMEQVRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSYRSSK-EGLVV 894
Query: 911 NTDEDWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK 969
+ A L + A ++ N+RL + ++EL + D ++T + + K
Sbjct: 895 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK 954
Query: 970 KDKEFEAKRKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIA 1025
A ++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+
Sbjct: 955 ------AMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP 1008
Query: 1026 LEIVDKLSNQKVALEKQIESLSNTPVS 1052
+++D + + L SL PVS
Sbjct: 1009 SKVLDDMDDDD-DLSTDGGSLYEAPVS 1034
Score = 62.5 bits (145), Expect = 8e-09
Identities = 147/742 (19%), Positives = 305/742 (41%), Gaps = 55/742 (7%)
Query: 25 NQLDGAKSKNDNIIETQSN-PIKLQD-SGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
NQ + S+ +++E +S I++ + + + K Q++KE + LE+L +
Sbjct: 345 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 404
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E+ S L+ + + E + R L ++ ++ME EI++L D L +++
Sbjct: 405 EKVEENSTLQQRLEES--EGELRKNL-EELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 461
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI-DLEKLVNESENKIGPKNI 201
+ D ++E + ++ +++ K+ E L +K +L L + ++ +
Sbjct: 462 AKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ 521
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD-AGRE-DCKEL 259
KLKE YD L L S+ ++ + + SE D AG E K L
Sbjct: 522 -EMDKLKEQ--------YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 572
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E+ ++ E E + L ++ + E KA + + + + + L E L++ K
Sbjct: 573 QEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-K 630
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K+ + + +L L+A G S E + K + + ++ E+ +++ ++
Sbjct: 631 EEKEAVSARR-ALENELEAAQGNLSQTTQE--QKQLSEKLKEESEQ-KEQLRRLKNEMEN 686
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE-ILT 438
L EKL + ++E + L +Q + + E ++ + + +LKE L
Sbjct: 687 ERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLE 744
Query: 439 KECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLETG 495
E +L+ +K+ D R ++++L +++ L + + L +YE+E K L+
Sbjct: 745 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDD 803
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
++ V LEE N L E +++ + ++++ L + +
Sbjct: 804 RSRLVKQMEDKVSQLEME----LEEERNNSDLLSERISRS-REQMEQVRNELLQERAARQ 858
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+++ KI++ + + + S ++ L + KE L + E E +
Sbjct: 859 DLECDKISLERQNKDLKS------RIIHLEGSYRSSKE---GLVVQMEARIAELEDRLES 909
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
ER ++ + L++ +++M D+ L + A+K Q EE
Sbjct: 910 EERDRANLQLSNRRLERKVKELVMQVDDEHLSLT------DQKDQLSLRLKAMKRQVEEA 963
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ RLE + K ++ E Q M LQ Q+ ++K+ +L +L +K D
Sbjct: 964 EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS-----MKKDLRLKKLPSKVLDDMDDD 1018
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
D D S EA T KD
Sbjct: 1019 DDLSTDGGSLYEAPVSYTFSKD 1040
Score = 59.3 bits (137), Expect = 8e-08
Identities = 99/448 (22%), Positives = 194/448 (43%), Gaps = 58/448 (12%)
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
NL ++ K+R + N + T+E+++ + + + I+ + ++++ +L E+
Sbjct: 324 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQL-EV 379
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
N+ + +K + + +LE R N+ + ++ R+ E E ++R
Sbjct: 380 KNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 438
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
DE DS KRS D E L E LL +Q+L
Sbjct: 439 EQHQTEIRDLQDQLSEMHDEL----------DSAKRS----EDREKGALIEELLQAKQDL 484
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLK---KEKLSL-EQQVSNLKEQIRTQ---- 896
DL +E +D L++R+ + LK KE++S +Q++ LKEQ +
Sbjct: 485 QDLLIAKEEQED-------LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 537
Query: 897 -QPVERQAKFADVAV---NTDE-DWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKK 950
+ VE K +V NT E D A V + +++ +++ L + + +L+ +
Sbjct: 538 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 597
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFE-----AKRKELEDCKA------ELEELKQRYKELD 999
+DLK K ++ ++KY + ++ E A+++E E A ELE + +
Sbjct: 598 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 657
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+E + +E LK+ EQ ++L+ K +++ N++ L K IE L +++
Sbjct: 658 QEQKQLSEKLKEESEQKEQLRRLK------NEMENERWHLGKTIEKLQK-EMADIVEASR 710
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
T + +QNQ K ++L +M +L
Sbjct: 711 TSTLELQNQLDEYKEKNRRELAEMQRQL 738
Score = 56.0 bits (129), Expect = 7e-07
Identities = 115/561 (20%), Positives = 226/561 (40%), Gaps = 37/561 (6%)
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
+EVK L E+ +KL +V E L L + I + + N E++ S + + K+
Sbjct: 352 SEVKDLLEQKSKL-TIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS--QHNEKVE 408
Query: 583 ELVSTINGLKEENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E + L+E L K+L ++ + E + + E I+ +L +M ++
Sbjct: 409 ENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTE-----IRDLQDQLSEMHDELDSAK 463
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+AK L+ L KE+ E+ R R +K K + M
Sbjct: 464 RSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 523
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
K+ Q D +L +E+ + E T E L + + +D + V L + + ++G
Sbjct: 524 DKLKE-QYDAELQALRES-VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQG 581
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
R ELE + Q + + K S +R+
Sbjct: 582 RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA 641
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ ++E+ + L QE L E+ KE ++ E E + + L K
Sbjct: 642 L----ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 697
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLM 940
L+++++++ E RT +E Q + + + A + + ++ E EK++ M
Sbjct: 698 LQKEMADIVEASRTST-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAM 753
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAEL----- 988
K +E+R +++L++ +A+ K T KD E+E AK L+D ++ L
Sbjct: 754 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQME 812
Query: 989 EELKQRYKELDEE---CETCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIE 1044
+++ Q EL+EE + +E + + EQ ++++ + L K++LE+Q +
Sbjct: 813 DKVSQLEMELEEERNNSDLLSERISRSREQMEQVRNELLQERAARQDLECDKISLERQNK 872
Query: 1045 SLSNTPVSNSTMYVATGSAIV 1065
L + + Y ++ +V
Sbjct: 873 DLKSRIIHLEGSYRSSKEGLV 893
>AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein
protein.
Length = 1331
Score = 68.9 bits (161), Expect = 9e-11
Identities = 95/511 (18%), Positives = 204/511 (39%), Gaps = 31/511 (6%)
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+ L EE + K ++++ L K L EE+D L + + + +L +K K +L+
Sbjct: 814 EQLEEEESARQKLQLEKVTTEAKLKK-LEEELDDLLVDLDHQRQSACNLEKKQKKFDQLL 872
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+ + + + + REKET+A L R+ + + EL+++
Sbjct: 873 AEEKTISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 932
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
E L + AL++Q EE LE ++ E +RL+
Sbjct: 933 SSKDDVGKSVHE---LEKSKRALEQQVEEMKTQLEELEGELQATEDAK-------LRLEV 982
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAE 765
+Q F E L + E K+ V+++E+ E + Q+ + +
Sbjct: 983 NLQAMKAQF---ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERK---QRSMAVAARKK 1036
Query: 766 LESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVI 825
LE D++ + D R+L ++ + + +
Sbjct: 1037 LEMDLKDLEA---HIDSANKNRDEAIKQLRKLQAQMKDCMREL-DDTRASREEILAQAKE 1092
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
++ ++ ++ ++ Q+EL + ++ E + A+ + + A +EK LE +
Sbjct: 1093 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1152
Query: 886 VSNLKEQIRTQQP----VERQAKFADV---AVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
++ L+E++ +Q + + K A++ +NTD + H+ + E +NK
Sbjct: 1153 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE-RQNKE 1211
Query: 939 LMKTIEELR-YKKQDLKNTVTKMQ-KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
L ++E+ K K ++T ++ K + + D E + ++ + + ++LK
Sbjct: 1212 LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLL 1271
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
++D+E +Y Q ++ RLK+ K LE
Sbjct: 1272 QVDDERRNAEQYKDQADKASTRLKQLKRQLE 1302
Score = 54.8 bits (126), Expect = 2e-06
Identities = 115/623 (18%), Positives = 243/623 (39%), Gaps = 40/623 (6%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL V EK + ++L E E + L +K ++ E A T ++ + EL+ LT +
Sbjct: 717 ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET-ELCAEAEELRARLTAKKQ 775
Query: 443 KLSKLKIDIPRDLDQD------LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
+L ++ D+ ++++ L A KK I + E + E ++KL+LE T
Sbjct: 776 ELEEICHDLEARVEEEEERCQHLQAEKK---KMQQNIQELEEQLEEEESARQKLQLEKVT 832
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
+A D ++ ++ ++ +L +E + + E
Sbjct: 833 TEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLL---AEEKTISAKY----AGE 885
Query: 557 IDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS-- 614
D + + E K LSL+ + E + + L ++ + + D+++ + + S
Sbjct: 886 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT--EMEDLMSSKDDVGKSVH 943
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK-EQCE 673
ELE+S + ++Q E+ ++ K+ E++L + EQ E
Sbjct: 944 ELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSE 1003
Query: 674 EKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK- 732
EK + R ++ + Q M + +K+++ D K N+ N+ EA+K
Sbjct: 1004 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK--NRDEAIKQ 1061
Query: 733 -RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
R A +KD RE + ++++++ + E E +++ + +
Sbjct: 1062 LRKLQAQMKDC--MRELDDTRASREEIL-AQAKENEKKLKSMEAEMIQLQEELAAAERAK 1118
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERY 851
DE + L KR + ++ ++QL+E L Q + + +R
Sbjct: 1119 RQAQQERDELADEIANSSGKGALALEEKRRL----EARIAQLEEELEEEQGNTELINDRL 1174
Query: 852 KELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVN 911
K+ + + + L + + + LE+Q LK +++ + + A +
Sbjct: 1175 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITA- 1233
Query: 912 TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKD 971
+ A L + D E ++ + K + K +D+ V ++ E+Y +
Sbjct: 1234 LEAKIAQLEEQL------DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA 1287
Query: 972 KEFEAKRKELEDCKAELEELKQR 994
+ + K+L+ E EE QR
Sbjct: 1288 DKASTRLKQLKRQLEEAEEEAQR 1310
Score = 53.2 bits (122), Expect = 5e-06
Identities = 97/462 (20%), Positives = 194/462 (41%), Gaps = 58/462 (12%)
Query: 598 LKSLNDVITREKETQASELE----RSCQVIKQNGF-ELDKMKADILMXXXXXXXXXXXXX 652
+K L V +E+E A E E R Q+ +N E++ +++ ++
Sbjct: 698 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 757
Query: 653 XXXDEAKSLLEQNLALKEQCEEKTRDC-SRLEINIKTHEKTAEIQNRM---IMRLQKQIQ 708
EA+ L + A K++ EE D +R+E + + + +M I L++Q++
Sbjct: 758 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 817
Query: 709 EDD----KLFIEK---ETKLNELTNKYEALKRDYD---AAVKDLESSREAVNQLTTQKDL 758
E++ KL +EK E KL +L + + L D D + +LE ++ +QL ++
Sbjct: 818 EEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 877
Query: 759 VEGRIA----ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKL 814
+ + A E++ R ++T + F E DL +
Sbjct: 878 ISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK-- 935
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR 874
DD K V +L++ + +Q+++++K + +EL+ E LQ ++
Sbjct: 936 DDVGK---------SVHELEKSKRALEQQVEEMKTQLEELEGE-------LQATEDA--- 976
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
KL LE + +K Q ER + D ++E L V + M + E E
Sbjct: 977 ----KLRLEVNLQAMKAQF------ERDLQGRDE--QSEEKKKQLVRQVRE-MEAELEDE 1023
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
+ +R M + + + DLK+ + A + + K+ + +++DC EL++ +
Sbjct: 1024 RKQRSM-AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1082
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+E+ + + + LK E + +L+E A E + + Q+
Sbjct: 1083 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE 1124
Score = 51.6 bits (118), Expect = 2e-05
Identities = 57/292 (19%), Positives = 130/292 (44%), Gaps = 17/292 (5%)
Query: 828 SEVSQLKERLLSCQQ---ELDDLKERY----KELDDECETCAEYLQERDEQCARLKKEKL 880
+E QL+E+L + + E ++L+ R +EL++ C ++E +E+C L+ EK
Sbjct: 744 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 803
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNT--DEDWANLHSVVVDRMSYDAEVEKNKR 938
++Q + L+EQ+ ++ ++ + V + L ++VD ++
Sbjct: 804 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEK 863
Query: 939 LMKTIEELRYKKQDLK-NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
K ++L +++ + + +A + +K+ + + + LE+ + EL++ K+
Sbjct: 864 KQKKFDQLLAEEKTISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 923
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEKQIESLSNTPVSNSTM 1056
E E + L+++K ALE V+++ Q LE ++++ + +
Sbjct: 924 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVN 983
Query: 1057 YVATGSAIVQNQQITDVMKENQK------LKKMNAKLITICKKRGKTGANRE 1102
A + ++ Q D E +K +++M A+L K+R A R+
Sbjct: 984 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1035
Score = 44.4 bits (100), Expect = 0.002
Identities = 56/261 (21%), Positives = 120/261 (45%), Gaps = 27/261 (10%)
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
P L S + + + E+ +++E+ L+ + L +++ +L E E LQ E
Sbjct: 700 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 759
Query: 872 CA-------RLKKEKLSLEQQVSNLKEQIRTQ---------QPVERQAKFADVAVNTDED 915
CA RL +K LE+ +L+ ++ + + + Q ++ +E+
Sbjct: 760 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 819
Query: 916 WANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
+ + +++++ +A+++K + L + +L +++Q N + K QK ++ ++K
Sbjct: 820 ESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACN-LEKKQKKFDQLLAEEKTI 878
Query: 975 EAK-RKELEDCKAELEELKQR----YKELDEECETCAE---YLKQREEQCKRLKEAKIAL 1026
AK E + +AE E + + + L+E E AE KQ + + L +K +
Sbjct: 879 SAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 938
Query: 1027 -EIVDKLSNQKVALEKQIESL 1046
+ V +L K ALE+Q+E +
Sbjct: 939 GKSVHELEKSKRALEQQVEEM 959
Score = 43.2 bits (97), Expect = 0.005
Identities = 81/468 (17%), Positives = 201/468 (42%), Gaps = 34/468 (7%)
Query: 329 KDSLLAVLDAEFGTTS-LDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSV 387
++ L+ V + + + L E L ++ + ++ L E L+ T++ + E + L +
Sbjct: 715 EEELVKVREKQLAAENRLTEMETLQSQLMAE-KLQLQEQLQAETELCAEAEELRARLTAK 773
Query: 388 NEKLAS----LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-----ELKEILT 438
++L L +++ E+E C L+ +K+++ + + + ++E+ +L+++ T
Sbjct: 774 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 833
Query: 439 KECLKLSKLKID-IPRDLDQDLPAH---KKITILFDALITQYELSRTDYEIEKEKLRLET 494
+ LK + ++D + DLD + +K FD L+ + + Y E+++ E
Sbjct: 834 EAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAGERDRAEAEA 893
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILS 554
+ LEEA + L E L K +++++++ ++ + +
Sbjct: 894 REKETKALSLARA----------LEEAMEQKAEL-ERLNKQFRTEMEDLMSSKDDVGKSV 942
Query: 555 EEIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
E++ K A+ + E+M + L E + +L L+ ++K+ + + ++ Q+
Sbjct: 943 HELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1002
Query: 614 SELERSC-QVIKQNGFELD---KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK 669
E ++ + +++ EL+ K ++ + D A ++ +
Sbjct: 1003 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1062
Query: 670 EQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
+ + + +DC R E++ T EI + +K+++ + I+ + +L
Sbjct: 1063 RKLQAQMKDCMR-ELD-DTRASREEILAQA-KENEKKLKSMEAEMIQLQEELAAAERAKR 1119
Query: 730 ALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
+++ D ++ +S +K +E RIA+LE ++ EQ T
Sbjct: 1120 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1167
Score = 42.3 bits (95), Expect = 0.009
Identities = 72/391 (18%), Positives = 154/391 (39%), Gaps = 30/391 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E + Q+
Sbjct: 738 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 797
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN 157
L E + + I+ LE + ++ + L T K+ +L+EE D L
Sbjct: 798 LQAEKKK---MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEELDDL------- 847
Query: 158 VTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHI 217
+ + D+ + +L+K + Q + EK ++ K + A+ + +E ++L +
Sbjct: 848 LVDLDHQRQSACNLEKKQKKFDQLLAE-EKTISA---KYAGERDRAEAEAREKETKALSL 903
Query: 218 GYDNTLSKLNRSISDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
L ++ R NK T +L + ++D + + K LE
Sbjct: 904 A-----RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 958
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLI--NNESKKSKDHIDRYKDSLLA 334
M L+E GE E +++ ++ L + +S++ K + R + A
Sbjct: 959 MKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA 1018
Query: 335 VLDAEFGTTSLDV-----FEILMDNI---INKYQIDLDEILEKYTKVQGDLNECTSELKS 386
L+ E S+ V E+ + ++ I+ + DE +++ K+Q + +C EL
Sbjct: 1019 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDD 1078
Query: 387 VNEKLASLNSQLIEKENACNILRIQKERIHE 417
+ +Q E E + + ++ E
Sbjct: 1079 TRASREEILAQAKENEKKLKSMEAEMIQLQE 1109
Score = 40.3 bits (90), Expect = 0.037
Identities = 102/545 (18%), Positives = 221/545 (40%), Gaps = 56/545 (10%)
Query: 538 SKVDENNANLNLIKILSEEI-DALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
++ +E A L K EEI L+ + + EE+ L + K+ + I L+E+
Sbjct: 761 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQ---NIQELEEQLE 817
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL-MXXXXXXXXXXXXXXXX 655
+S + EK T ++L++ + + +LD + +
Sbjct: 818 EEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 877
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI 715
AK E++ A E E++T+ S + E+ AE++ RL KQ +
Sbjct: 878 ISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELE-----RLNKQFR------- 925
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
T++ +L + K D +V +LE S+ A+ Q Q + ++ ++ ELE +++ +
Sbjct: 926 ---TEMEDLMSS----KDDVGKSVHELEKSKRALEQ---QVEEMKTQLEELEGELQATED 975
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL-GENPKLDDSPKRSISVISDSEVSQLK 834
A + RDL G + + ++ K+ + + + E ++L+
Sbjct: 976 AKLRLEVNLQAMKAQF-------------ERDLQGRDEQSEEKKKQLVRQVREME-AELE 1021
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
+ + K+ +L D + RDE +L+K + ++ + L +
Sbjct: 1022 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1081
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQD-L 953
+++ + QAK E+ L S+ + + E+ +R + ++ R + D +
Sbjct: 1082 SREEILAQAK---------ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1132
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE 1013
N+ K A+E+ + + +ELE+ + E + R K+ + + + L
Sbjct: 1133 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1192
Query: 1014 EQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDV 1073
++ + A+ LE +K KV L++ ++ + ++ T A + + +Q+ +
Sbjct: 1193 SHAQKNENARQQLERQNK--ELKVKLQEMEGTVKSKYKASITALEAKIAQL--EEQLDNE 1248
Query: 1074 MKENQ 1078
KE Q
Sbjct: 1249 TKERQ 1253
Score = 39.9 bits (89), Expect = 0.049
Identities = 40/192 (20%), Positives = 88/192 (45%), Gaps = 15/192 (7%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N +T+M+ + + + +
Sbjct: 691 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 750
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLKEAKIAL----- 1026
+ + + AE EEL+ R +EL+E C +++ EE+C+ L+ K +
Sbjct: 751 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 810
Query: 1027 EIVDKLSNQKVALEK-QIESLSNTPVSNSTMYVATGSAIV----QNQQITDVMKENQKLK 1081
E+ ++L ++ A +K Q+E ++ T + +V Q Q ++ K+ +K
Sbjct: 811 ELEEQLEEEESARQKLQLEKVT-TEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFD 869
Query: 1082 KMNAKLITICKK 1093
++ A+ TI K
Sbjct: 870 QLLAEEKTISAK 881
>U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein.
Length = 1017
Score = 68.5 bits (160), Expect = 1e-10
Identities = 157/790 (19%), Positives = 339/790 (42%), Gaps = 81/790 (10%)
Query: 292 ETKAVKVMSEIKRNLN---SLSEQLINNESKKSK-DHIDRY-----KDSLLAVLDAEFGT 342
E V++ ++ K+ L+ L E+ N+S K K ++++R ++ L +LDAE
Sbjct: 25 EKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQMSEENQELVILDAENSK 84
Query: 343 TSLDVFEILMDNI---INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLI 399
++ + ++ + + +++DL + + + + E +L +++ L+S SQL
Sbjct: 85 AEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSQLE 144
Query: 400 EKENACNILRIQKERIHEISSAVTIDIVKKENELKEIL--TKECLKLSKLKIDIPRDLDQ 457
EKE A IQ + + + + + +K+ NE L +E +K ++ +D P + +
Sbjct: 145 EKEQA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 200
Query: 458 DL-PAHKKITILFDA-----LITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXX 506
L + +K+ +A L +L +++ + E L E A+
Sbjct: 201 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAAL 260
Query: 507 XXXXXXXXFDTL----EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE-EI--DA 559
+TL E ++ L ++ + K D N + +SE EI +
Sbjct: 261 EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSS 320
Query: 560 LKIAIAKNEEKMLSLSEKDNKLTELVST--INGLKEENNSLKSLNDVITREK----ETQA 613
+ + + E++ + + EK + E++ T + ++E + + V +E+ + +
Sbjct: 321 FENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVEC 380
Query: 614 SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCE 673
ELE++ Q+++ LD+ K + ++ + + E+ LK Q +
Sbjct: 381 LELEKA-QLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 435
Query: 674 EKTRDCSRLEINIKTH----EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE 729
++ + S+L H E+ E++N + + L+++IQ + L L + Y+
Sbjct: 436 DQEQLVSKLSQVEGEHQLWKEQNLELRN-LTVELEQKIQVLQSKNASLQDTLEVLQSSYK 494
Query: 730 ALKRDYDAAVKDLESSREAVNQLTT-----QKDLVE--GRIAELESDIRTEQTATVXXXX 782
L+ + + D S E VN++T Q+++ E + AEL+ ++ E+
Sbjct: 495 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 554
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD--SEVSQLKERLLSC 840
EN +L ++ LD K + E+++ + RL
Sbjct: 555 LLLEEIKSSKDQLKELTL---ENSELKKS--LDCMHKDQVEKEGKVREEIAEYQLRLHEA 609
Query: 841 QQELDD-LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+++ L + K+ + E +T E L + E+C L +KL ++ S+ KE++ +
Sbjct: 610 EKKHQALLLDTNKQYEVEIQTYREKLTSK-EEC--LSSQKLEIDLLKSS-KEELNNS--L 663
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ + + T D NL V + + K K L+K+ ++L +K+ L+ +++
Sbjct: 664 KATTQILEELKKTKMD--NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQ 721
Query: 960 MQKAMEKY---TKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEECETCAEYLKQREEQ 1015
+Q A EK T D + + E+++ K LEE K+ + LD+ C + ++ E+
Sbjct: 722 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH--EKLEK 779
Query: 1016 CKRLKEAKIA 1025
K + E ++A
Sbjct: 780 AKEMLETQVA 789
Score = 66.9 bits (156), Expect = 4e-10
Identities = 108/473 (22%), Positives = 213/473 (45%), Gaps = 42/473 (8%)
Query: 61 QSLKESSNEINL---KLEKLSGELFDIK--EQKSALEGKYQNLILETQTRDL--LMSQIK 113
Q LKES + +L ++E L EL + ++ +ALE + +ET + + ++
Sbjct: 225 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 284
Query: 114 SLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKE------ 167
LE++ +T E ++LT+ L+ + ++I+EL+ N + N++ E E + ++
Sbjct: 285 GLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAME 344
Query: 168 -VDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTL--- 223
+ K++ Q CI +K V+ E + + C + + K L+Q L +N +
Sbjct: 345 MLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELE-KAQLLQGLDEAKNNYIVLQ 403
Query: 224 SKLNRSISD-SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEP------N 276
S +N I + + + K S L +D ++L + ++ +L + N
Sbjct: 404 SSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRN 463
Query: 277 MTMDLDEK---LGENNEFETKAVKVMSEIKRNL-NSLSEQLINNESKKSKDHIDRYKDSL 332
+T++L++K L N ++V+ +NL N L ++ S K + K++
Sbjct: 464 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 523
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
L E + ++ E L N+ +L +LE+ + L E T E + + L
Sbjct: 524 LQREMHEMAQKTAELQEELSGE-KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLD 582
Query: 393 SLNSQLIEKENAC-NILRIQKERIHEIS---SAVTIDIVKK-ENEL---KEILT--KECL 442
++ +EKE + + R+HE A+ +D K+ E E+ +E LT +ECL
Sbjct: 583 CMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECL 642
Query: 443 KLSKLKIDIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLE 493
KL+ID+ + ++L K T IL + T+ + + +++KE R +
Sbjct: 643 SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQ 695
Score = 61.3 bits (142), Expect = 2e-08
Identities = 103/519 (19%), Positives = 206/519 (39%), Gaps = 30/519 (5%)
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEK----DNKLTELVSTINGLKEENNSLKSLNDVITRE 608
L I+ L++ I +E+K L ++EK D + L + L+ E + +++ +
Sbjct: 20 LRRGIEKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQMSEENQELVILD 79
Query: 609 KETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL 668
E +E+E I++ L + D++ + L + +
Sbjct: 80 AENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 139
Query: 669 KEQCEEKTRDCSRLEINIKTHEKTA-EIQNRMIMRLQKQIQE---DDKLFIEKETKL--- 721
K Q EEK + EI IK KTA E+ + L + + D ++ E L
Sbjct: 140 KSQLEEK----EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 195
Query: 722 ----NELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
++L N E L+ +A K + + + DL++GR+ LE ++ +T
Sbjct: 196 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 255
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE---VSQLK 834
R L + S K ++ E +S+L+
Sbjct: 256 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELE 315
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
S + L + ++ ++ ++ T E LQ + + R + + ++ VS KEQ
Sbjct: 316 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVS-AKEQNL 374
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEE---LRYKK 950
+ Q + + A + DE N + EVE K +L K EE L+ +
Sbjct: 375 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 434
Query: 951 QDLKNTVTKM-QKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
QD + V+K+ Q E K++ E + +E + +++ L+ + L + E
Sbjct: 435 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE-LEQKIQVLQSKNASLQDTLEVLQSSY 493
Query: 1010 KQREEQCKRLKEAKIA-LEIVDKLSNQKVALEKQIESLS 1047
K E + + K K++ +E V+K++ ++ L++++ ++
Sbjct: 494 KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMA 532
Score = 60.9 bits (141), Expect = 2e-08
Identities = 145/779 (18%), Positives = 322/779 (41%), Gaps = 73/779 (9%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD 282
+S+ N+ + + ++ TL+++++ K D ++++ E N+T +
Sbjct: 68 MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE----NLTKQIQ 123
Query: 283 EKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGT 342
EK G+ +E + K++S K L EQ ++SK ++ ++ L + +A
Sbjct: 124 EKQGQLSELD----KLLSSFKSQLEE-KEQAEIQIKEESKTAVEMLQNQLKELNEA---- 174
Query: 343 TSLDVFEILMDNIINKY-QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK 401
V + D I K + LD +E+ +++ + + + L++ +K + QL E
Sbjct: 175 ----VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES 230
Query: 402 ENACNILRIQKERIH-EISSAVTID---IVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E+ ++L+ + E + E+ A T ++ EN E+ T + K+ + + R L+
Sbjct: 231 EHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA-KIEGMTQSL-RGLEL 288
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
D+ +TI + EL + I + ++ + + +
Sbjct: 289 DV-----VTIRSEKEDLTNELQKEQERISELEI-INSSFENILQEKEQEKVQMKEKSSTA 342
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
+E ++KS E +K + NL S +++ L++ A + + L E
Sbjct: 343 MEMLQTQLKSSMREWQPCIMTKKPVSAKEQNL----SSQVECLELEKA---QLLQGLDEA 395
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N L S++NGL +E K + +K+ + S L+ Q +Q +L +++ +
Sbjct: 396 KNNYIVLQSSVNGLIQEVEDGKQKLE----KKDEEISRLKNQIQDQEQLVSKLSQVEGEH 451
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE--INIKTHEKTAEI 695
+ + + L +N +L++ E LE + + +K + +
Sbjct: 452 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 511
Query: 696 Q--NRMIMRLQKQIQEDDKLFIEKETKLNE-LTNKYEALKRDYDAAVKDLESSREAVNQL 752
+ N+M + + ++Q + +K +L E L+ + L + +++++SS++ + +L
Sbjct: 512 EKVNKMTAK-ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 570
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
T + ++ + + D + E+ V E +
Sbjct: 571 TLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQLRLH-------------EAEKKHQAL 616
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQ-ELDDLKERYKELDDECETCAEYLQERDEQ 871
LD + + + + + E KE LS Q+ E+D LK +EL++ + + L+E
Sbjct: 617 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE---- 672
Query: 872 CARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
LKK K+ + V+ LK++ + + + K + E+ + + ++
Sbjct: 673 ---LKKTKMDNLKYVNQLKKE---NERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQ 726
Query: 932 EVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
E +K +M T ++EL + ++LK T+ + K ++Y K ++LE K LE
Sbjct: 727 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 785
Score = 59.7 bits (138), Expect = 6e-08
Identities = 146/731 (19%), Positives = 300/731 (41%), Gaps = 69/731 (9%)
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKL--ASLNSQLI--EKENACNILRIQKERIHEISSA 421
I EK + G+ + +++++ +L + N +L+ + EN+ + K +I E++ +
Sbjct: 41 IAEKLKERDGENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARS 100
Query: 422 VTI---DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-KITILFDALITQYE 477
+ + D+V +E KE LTK+ + K +LD+ L + K ++ A I E
Sbjct: 101 LKVFELDLVTLRSE-KENLTKQIQE----KQGQLSELDKLLSSFKSQLEEKEQAEIQIKE 155
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAH---NEVKSLHEELT 533
S+T E+ + +L+ E A A D +EE H N ++ L L
Sbjct: 156 ESKTAVEMLQNQLK-ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 214
Query: 534 KLYKSKV------DENNANLNLIKILSEEIDA-LKIAIAKNEEKMLSLSEKDNKLTELVS 586
K ++ E+ + +L+K E ++ L+IA E L ++ L +
Sbjct: 215 ADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA 274
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
I G+ + L+ I EKE +EL++ + I + + +
Sbjct: 275 KIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQ 334
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+ ++ L+ ++ + C + S E N+ + + E++ +++
Sbjct: 335 MKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELEKAQLLQ---G 391
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL 766
+ E +I ++ +N L + E K+ + KD E SR NQ+ Q+ LV +++++
Sbjct: 392 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK--KDEEISR-LKNQIQDQEQLVS-KLSQV 447
Query: 767 ESD--IRTEQTA-----TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPK 819
E + + EQ TV ++L +L K
Sbjct: 448 EGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDK 507
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE----TCAEYLQERDEQCARL 875
S +V+++ + Q+E+ ++ ++ EL +E A LQ E+
Sbjct: 508 MSFV----EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 563
Query: 876 KKEKLSLEQQVSNLKEQIRT--QQPVERQAK----FADVAVNTDEDWANLHSVVVD-RMS 928
K + L + S LK+ + + VE++ K A+ + E ++++D
Sbjct: 564 KDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQ 623
Query: 929 YDAEVEKNKRLMKTIEE-----------LRYKKQDLKNTVTKMQKAME--KYTKKD--KE 973
Y+ E++ + + + EE L+ K++L N++ + +E K TK D K
Sbjct: 624 YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKY 683
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
+KE E + +++ L + K+L+EE E + L Q + ++ K + VD+L+
Sbjct: 684 VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 743
Query: 1034 NQKVALEKQIE 1044
+ L++ +E
Sbjct: 744 TEIKELKETLE 754
Score = 57.6 bits (133), Expect = 2e-07
Identities = 123/578 (21%), Positives = 221/578 (38%), Gaps = 52/578 (8%)
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
TQ E+ + IEK ++R+E K + D +E E++ + EE
Sbjct: 13 TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQ-MSEE 71
Query: 532 LTKLYKSKVDENNANLNLIKILSEEID-ALKIAIAKNEEKMLSL-SEKDNKLTELVSTIN 589
+L + + A + +K EE+ +LK+ E +++L SEK+N ++
Sbjct: 72 NQELVILDAENSKAEVETLKTQIEEMARSLKVF----ELDLVTLRSEKENLTKQIQEKQG 127
Query: 590 GLKEENNSLKSLNDVITREK--ETQASELERSCQVIKQNGF-ELDKMKADILMXXXXXXX 646
L E + L S + ++ E Q E ++ + QN EL++ A +
Sbjct: 128 QLSELDKLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 187
Query: 647 XXXXXXXXXDEAKSLLE--QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQ 704
+E L + L + + +EK + C ++ K E A++ + L+
Sbjct: 188 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL--KESEHHADLLKGRVENLE 245
Query: 705 KQIQ----EDDKLFIEKETKLNE---LTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
++++ + +E E E L K E + + D+ + R LT +
Sbjct: 246 RELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQ 305
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
+ RI+ELE + + T + + +
Sbjct: 306 KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKK 365
Query: 818 PKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-------ECETCAEYLQERDE 870
P + S+V L+ Q LD+ K Y L E E + L+++DE
Sbjct: 366 PVSAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE 425
Query: 871 QCARLKKEKLSLEQQVSNLKE-QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ +RLK + EQ VS L + + Q E+ + ++ V ++ L S
Sbjct: 426 EISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS-------- 477
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKN--TVTKMQK-----AMEKYTKKDKEFEAKRKELE 982
KN L T+E L+ ++L+N +TKM K + K T K+ E + + E+
Sbjct: 478 -----KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMA 532
Query: 983 DCKAEL-EELKQRYKELDEECETCAEYLKQREEQCKRL 1019
AEL EEL L E + E +K ++Q K L
Sbjct: 533 QKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 570
Score = 57.2 bits (132), Expect = 3e-07
Identities = 141/735 (19%), Positives = 295/735 (40%), Gaps = 54/735 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL----E 116
++LK E+ L+ +L ++ +K L + Q + D L+S KS E
Sbjct: 88 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSQLEEKE 147
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINEL-------QEENDTLSNLIMENVTESDNLNKEVD 169
+ +E K + L+ + K++NE QE + + E L ++
Sbjct: 148 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 207
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN-TLSKLNR 228
L+ E +K + + + + ESE+ + ++ ENL + L I N + L
Sbjct: 208 KLRARLEADEKKQLCVLQQLKESEHHAD----LLKGRV-ENLERELEIARTNQEHAALEA 262
Query: 229 SISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT-MDLDEKLGE 287
S T KI + L D + + + N L+ + ++ +++ E
Sbjct: 263 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFE 322
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTS-LD 346
N E + KV + K +S + +++ + K S + V E +S ++
Sbjct: 323 NILQEKEQEKVQMKEK---SSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVE 379
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE-------LKSVNEKLASLNSQLI 399
E+ ++ LDE Y +Q +N E L+ +E+++ L +Q+
Sbjct: 380 CLELEKAQLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 435
Query: 400 EKENACNILRIQKERIHEISSAVTIDI----VKKENELKEILTKECLKLSKLKI--DIPR 453
++E + L Q E H++ +++ V+ E +++ + +K L++ +
Sbjct: 436 DQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 494
Query: 454 DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG-TAKAVXXXXXXXXXXXX 512
+L+ +L K + F + + T+ + E ++ +T + +
Sbjct: 495 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 554
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
+ ++ + +++K L E ++L KS + + + EEI ++ + + E+K
Sbjct: 555 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ 614
Query: 573 SLSEKDNKLTEL-VSTIN---GLKEENNSLKSLN-DVITREKETQASELERSCQVIKQNG 627
+L NK E+ + T KEE S + L D++ KE + L+ + Q+++
Sbjct: 615 ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE--- 671
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
EL K K D L + K L++ L+E+ E ++ S+L+ +
Sbjct: 672 -ELKKTKMDNL---KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA-AQ 726
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+KT + + + L +I+E + EK + +E +KY +L ++ K E
Sbjct: 727 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 786
Query: 748 AVNQLTTQKDLVEGR 762
V L +Q+ + R
Sbjct: 787 QVAHLCSQQSKQDSR 801
Score = 48.0 bits (109), Expect = 2e-04
Identities = 69/346 (19%), Positives = 151/346 (43%), Gaps = 16/346 (4%)
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
T E+ +++ R I +L+ +I+ D+K + KL E + ++LK + ++L+ S E
Sbjct: 13 TQEEVHQLR-RGIEKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQMSEE 71
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
NQ D E AE+E+ ++T+ + ++
Sbjct: 72 --NQELVILD-AENSKAEVET-LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG 127
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET-CAEYL 865
L E KL S K + +E+ Q+KE + ++ L+ + KEL++ C +
Sbjct: 128 QLSELDKLLSSFKSQLEEKEQAEI-QIKEE---SKTAVEMLQNQLKELNEAVAALCGD-- 181
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VNTDEDWANLHSVVV 924
QE + + + E Q+ N E++R + + + + + + E A+L V
Sbjct: 182 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 241
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ + + E+ + + +E K +++ K++ + + + R E ED
Sbjct: 242 ENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDL 300
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-AKIALEIV 1029
EL++ ++R EL+ + L+++E++ ++KE + A+E++
Sbjct: 301 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 346
>BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 68.5 bits (160), Expect = 1e-10
Identities = 186/997 (18%), Positives = 390/997 (39%), Gaps = 101/997 (10%)
Query: 66 SSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S NEI K LE + K+ + L+ + + + E + L ++K D+
Sbjct: 437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE------DSDE 490
Query: 125 EIKNLTDSLKTKSKKINELQ---EENDTLSNLIMENVTE--SDNLNKEVDDLKKNNECLT 179
+IK L D+LK K++ E + ++ T + E++T + ++ ++LK + L
Sbjct: 491 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
K V + N+I + + + K + + I + L K S+ + +
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVE-EFKRD--EGKLIEENKRLQK-ELSMCEMEREKKG 606
Query: 240 NKICTLQSELD--AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
K+ ++ + + + E F ++K+ L N + +KL E K++
Sbjct: 607 RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLS 662
Query: 298 VMSEIKRNLNSLSEQLINN----ESKKSKDHIDRYKDSL---LAVLDAEFGTTSLDVFEI 350
+ ++KR L ++ +L + E ++ K +++ L + L + T ++ ++
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Query: 351 LMDNIINKYQID--LDEILEKYT--KVQGDLNECTSEL-KSVNEKLASLNSQLIEKENAC 405
+DN + K Q E+ Y KV D+ + + +N KL + + EK+
Sbjct: 723 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEM 782
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKEC----LK--LSKLKIDIPRDLDQDL 459
L ++ + + + S + V E KEI+ + LK LS+LK D ++
Sbjct: 783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 842
Query: 460 PAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
+ T L + QY +T E+ K+ L AK T
Sbjct: 843 ALTSENTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAK------------------TNR 881
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
E +VK E++ + + D+N ++ +I A I++A++E KM SLS+
Sbjct: 882 ELL-DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR 940
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELE----RSCQVIKQN---GFEL-- 630
K+ + + I N K +++T E +A + E + C +K FE
Sbjct: 941 KVQDSNAEILA-----NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 995
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
K KA +E K ++N LK++ +D + I+
Sbjct: 996 RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
+ +R L KQ+++ + + E + +L + + A L+ +
Sbjct: 1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLE 1115
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q+ K + G I L+ ++++ Q + + L E
Sbjct: 1116 QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK-------NSSVPLAE 1168
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ ++ ++ ++ + +I S L+E+ Q +++++ + E+ + + +
Sbjct: 1169 HLQIKEAFEKEVGIIKAS----LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV 1224
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
++ K K LE Q+S+L E++ K+ +V LH+ +
Sbjct: 1225 DLSKYKATKSDLETQISSLNEKL-----ANLNRKYEEVCEEV------LHA---KKKEIS 1270
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
A+ EK +E++ +K+ ++T + + + + K+ EAK ++ + ++E
Sbjct: 1271 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1330
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
LKQ L + T K++ + L+ +LE
Sbjct: 1331 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLE 1367
Score = 66.9 bits (156), Expect = 4e-10
Identities = 161/791 (20%), Positives = 318/791 (40%), Gaps = 74/791 (9%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKES-SNEINLKLEKL-------SGELF 82
+ K + E + +L ++I + +++K S SNE+N K +KL L
Sbjct: 603 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLS 662
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKKIN 141
+I++ K LE L + + Q+KS LE ++ K+I LT +T K+I
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEE--HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
Query: 142 ELQEENDTLSNLIMENVTESDNLN---KEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
++ +N L E N K +D+KK+++ + DL + + + K
Sbjct: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID---DLNRKLLDVTQKYTE 777
Query: 199 KNICAQCKLKENLIQSLHIGYDNTL----SKLNRSIS--DSNTSTRYNKICTLQSELDAG 252
K + + L EN S + T+ K + I SN ++ L+ +
Sbjct: 778 KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGED 837
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
+E L + T++K + + + K+ N+ K + + ++K+ ++++
Sbjct: 838 QEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL-AKTNRELLDVKKKFEDINQE 896
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI---INKYQIDLDEILEK 369
+ + K + + R ++ + AE+ SL E M ++ + K Q EIL
Sbjct: 897 FVKIKDKN--EILKRNLENTQNQIKAEY--ISLAEHEAKMSSLSQSMRKVQDSNAEILAN 952
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
Y K Q ++ +E+K+ ++L ++ + I+ + A + + ER + +
Sbjct: 953 YRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKYAPIVSFEECERKFKAT---------- 1001
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
E ELK+ L+++ K S + ++ ++ ++ K+I L L + L +E+E+
Sbjct: 1002 EKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL 1061
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEE---AHNEVKSLHEELTKLYK--SKVDENN 544
R K + +EE +E+ ++ L K + +V+
Sbjct: 1062 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1121
Query: 545 ANLN-LIKILSEEIDALKIAIAKNEEKMLSLSEK-DNKLTELVSTINGL--KEENNSLKS 600
+LN I+ L EE+ +++ K ++ + L + +N+ V L KE
Sbjct: 1122 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVG 1181
Query: 601 LNDVITREKETQA-------SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ REKE ++ S+L+ Q KQ +L+ + L
Sbjct: 1182 IIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1241
Query: 654 XXDEAKSLLEQNLALKEQCEE----KTRDCSR----------LEINIKTHEKTAEIQNRM 699
+E L N +E CEE K ++ S +E IK ++ +
Sbjct: 1242 SLNE--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
I LQ++IQE K K+ K+ EL N E LK+ + + +S + + D +
Sbjct: 1300 ITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1359
Query: 760 EGRIAELESDI 770
+ ++ LE +
Sbjct: 1360 QHQVKSLEQQL 1370
Score = 66.5 bits (155), Expect = 5e-10
Identities = 189/996 (18%), Positives = 410/996 (41%), Gaps = 85/996 (8%)
Query: 94 KYQNLI-LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN 152
++QN+ LE + DL +++ ++ E ++ L L + ++L+ E + L +
Sbjct: 292 EHQNIQDLEIENEDL-KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKS 350
Query: 153 LIMENVTESDNLNKEVDDLKKNNECLTQKCIDL-EKLVNESENKIGPKN--ICAQCKLKE 209
L+ + + + ++ LK + + N E+ + + A +
Sbjct: 351 LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS 410
Query: 210 NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNH 269
I + H+ + L L S+ S TS N+I L+ EL+A R C+ +D ++N
Sbjct: 411 PGIPA-HMQSRSMLRPLELSLP-SQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNE 466
Query: 270 ----------LELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQ 312
L L + D DE++ + + K M E ++ + +L E
Sbjct: 467 LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI---LMDN--IINKYQIDLDEIL 367
L + + + + KD L L ++ S +V ++ + N I+ +++ D +++
Sbjct: 527 LTSEAASGNHRLTEELKDQ-LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 585
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIV 427
E+ ++Q +L+ C E + K+ + Q E +A L I E+ + S+++ ++
Sbjct: 586 EENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL-SAKLALSIPAEKFENMKSSLSNEVN 644
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQ---DLPAHKKITILFDALITQYELSRTDYE 484
+K +L E+ + LS+++ + R+L+ L H K + + ++ E +
Sbjct: 645 EKAKKLVEMEREHEKSLSEIR-QLKRELENVKAKLAQHVK-PEEHEQVKSRLEQKSGELG 702
Query: 485 IEKEKLRLETGT-AKAVXXXXXXXXXXXXXXFD-TLEEAHNEVK-SLHEELTKLYKSKVD 541
+ +L L+ T K + + T+E ++ V + E++ K + + +D
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
Query: 542 E-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+ N L++ + +E+ ++ + +N+ SLS+ ++L + ++E +LKS
Sbjct: 763 DLNRKLLDVTQKYTEKKLEMEKLLLEND----SLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
N V E + Q SEL++ C ++ L ++ +E K
Sbjct: 819 -NIV---ELKKQLSELKKKCGEDQEKIHALTSENTNL----KKMMSNQYVPVKTHEEVKM 870
Query: 661 LLEQNLALKEQ----CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
L LA + ++K D ++ + IK EI R + Q QI+ + E
Sbjct: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN---EILKRNLENTQNQIKAEYISLAE 927
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E K++ L+ +++++ D+ + L + R+ ++ T + I + ++ T Q
Sbjct: 928 HEAKMSSLS---QSMRKVQDSNAEILANYRKGQEEIVT----LHAEIKAQKKELDTIQEC 980
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
D+ + + + + + + E +LK+
Sbjct: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK----NKQENDKLKKE 1036
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ + Q++L D K E E E L + ++ + K+ +V N+KE++ +
Sbjct: 1037 IFTLQKDLRD-KTVLIEKSHEMERA---LSRKTDELNKQLKDLSQKYTEVKNVKEKL-VE 1091
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+ ++ ++ V + L V + S + +E K +K+++ Y+K+ + T
Sbjct: 1092 ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRC-YEKE--QQT 1148
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
VTK+ + +E + E + E+ +K +E +EE + E + + + +
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
Query: 1017 KRLKEAKIAL---EIVD--KLSNQKVALEKQIESLS 1047
+ K+A L E+VD K K LE QI SL+
Sbjct: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1244
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/276 (18%), Positives = 125/276 (45%), Gaps = 21/276 (7%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+V++ K L C++ +D E+ K+L+D + + + E + + +++ L+L++ +++
Sbjct: 470 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTS 529
Query: 889 --------LKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE--VEKNK 937
L E+++ Q + ++ + + A V + + ++V+ D +E+NK
Sbjct: 530 EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK 589
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
RL K + +++ VT+M+ ++ + K ++ E+ K+ L E
Sbjct: 590 RLQKELSMCEMEREKKGRKVTEMEGQAKELSAK-LALSIPAEKFENMKSSLS------NE 642
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
++E+ + E ++ E+ +++ K LE V Q V E+ + S + +
Sbjct: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
Query: 1058 VATGSAIVQNQQITDVMKE---NQKLKKMNAKLITI 1090
++NQ + +++ + KL K A +TI
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Score = 44.4 bits (100), Expect = 0.002
Identities = 89/466 (19%), Positives = 196/466 (42%), Gaps = 55/466 (11%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+S + L L+ + K +C L + E+ E + I +L+ +++ K E E
Sbjct: 454 ESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYESE 510
Query: 719 TKLNELTNKYEALKRDY--DAAVKDLESSREAVNQLTTQKDLVEG---RIAELESDIRTE 773
K+ ++ + ALK +AA + + E +QL K EG + +L + I+
Sbjct: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG------ENPKLDDSPKRSISVISD 827
+ E G E + S K ++S+ ++
Sbjct: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
Query: 828 ----------SEVSQLKERLLSCQQE----LDDLKERYKELDDECETCAEYL--QERDEQ 871
+EV++ ++L+ ++E L ++++ +EL++ A+++ +E ++
Sbjct: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
Query: 872 CARLKKEKLSLEQQVSNLKEQIRT-QQPVER----QAKFADVAVNTDEDWANLH---SVV 923
+RL+++ L ++++ L + +T Q+ +E+ + A N + N + V
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
Query: 924 VD-RMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF---EAKR 978
D + S+DA ++ N++L+ ++ KK +++ + + + ++ + F E
Sbjct: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
KE+ K+ + ELK++ EL ++C E + + LK+ +SNQ V
Sbjct: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK---------MMSNQYVP 861
Query: 1039 LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ K E + T N T+ + ++ D+ +E K+K N
Sbjct: 862 V-KTHEEVKMT--LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
Score = 33.1 bits (72), Expect = 5.7
Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
IE + K + ++T ++ + ++ES+ +I K K++ L D++ K AL G Q
Sbjct: 1282 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQL 1341
Query: 98 LIL-------ETQTRDLLMSQIKSLEMENLTKDKE 125
++Q D L Q+KSLE + D++
Sbjct: 1342 TYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
>BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 68.5 bits (160), Expect = 1e-10
Identities = 186/997 (18%), Positives = 390/997 (39%), Gaps = 101/997 (10%)
Query: 66 SSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S NEI K LE + K+ + L+ + + + E + L ++K D+
Sbjct: 437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE------DSDE 490
Query: 125 EIKNLTDSLKTKSKKINELQ---EENDTLSNLIMENVTE--SDNLNKEVDDLKKNNECLT 179
+IK L D+LK K++ E + ++ T + E++T + ++ ++LK + L
Sbjct: 491 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
K V + N+I + + + K + + I + L K S+ + +
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVE-EFKRD--EGKLIEENKRLQK-ELSMCEMEREKKG 606
Query: 240 NKICTLQSELD--AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
K+ ++ + + + E F ++K+ L N + +KL E K++
Sbjct: 607 RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLS 662
Query: 298 VMSEIKRNLNSLSEQLINN----ESKKSKDHIDRYKDSL---LAVLDAEFGTTSLDVFEI 350
+ ++KR L ++ +L + E ++ K +++ L + L + T ++ ++
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Query: 351 LMDNIINKYQID--LDEILEKYT--KVQGDLNECTSEL-KSVNEKLASLNSQLIEKENAC 405
+DN + K Q E+ Y KV D+ + + +N KL + + EK+
Sbjct: 723 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEM 782
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKEC----LK--LSKLKIDIPRDLDQDL 459
L ++ + + + S + V E KEI+ + LK LS+LK D ++
Sbjct: 783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 842
Query: 460 PAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
+ T L + QY +T E+ K+ L AK T
Sbjct: 843 ALTSENTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAK------------------TNR 881
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
E +VK E++ + + D+N ++ +I A I++A++E KM SLS+
Sbjct: 882 ELL-DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR 940
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELE----RSCQVIKQN---GFEL-- 630
K+ + + I N K +++T E +A + E + C +K FE
Sbjct: 941 KVQDSNAEILA-----NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 995
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
K KA +E K ++N LK++ +D + I+
Sbjct: 996 RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
+ +R L KQ+++ + + E + +L + + A L+ +
Sbjct: 1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLE 1115
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q+ K + G I L+ ++++ Q + + L E
Sbjct: 1116 QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK-------NSSVPLAE 1168
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ ++ ++ ++ + +I S L+E+ Q +++++ + E+ + + +
Sbjct: 1169 HLQIKEAFEKEVGIIKAS----LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV 1224
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
++ K K LE Q+S+L E++ K+ +V LH+ +
Sbjct: 1225 DLSKYKATKSDLETQISSLNEKL-----ANLNRKYEEVCEEV------LHA---KKKEIS 1270
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
A+ EK +E++ +K+ ++T + + + + K+ EAK ++ + ++E
Sbjct: 1271 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1330
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
LKQ L + T K++ + L+ +LE
Sbjct: 1331 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLE 1367
Score = 66.9 bits (156), Expect = 4e-10
Identities = 161/791 (20%), Positives = 318/791 (40%), Gaps = 74/791 (9%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKES-SNEINLKLEKL-------SGELF 82
+ K + E + +L ++I + +++K S SNE+N K +KL L
Sbjct: 603 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLS 662
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKKIN 141
+I++ K LE L + + Q+KS LE ++ K+I LT +T K+I
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEE--HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
Query: 142 ELQEENDTLSNLIMENVTESDNLN---KEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
++ +N L E N K +D+KK+++ + DL + + + K
Sbjct: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID---DLNRKLLDVTQKYTE 777
Query: 199 KNICAQCKLKENLIQSLHIGYDNTL----SKLNRSIS--DSNTSTRYNKICTLQSELDAG 252
K + + L EN S + T+ K + I SN ++ L+ +
Sbjct: 778 KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGED 837
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
+E L + T++K + + + K+ N+ K + + ++K+ ++++
Sbjct: 838 QEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL-AKTNRELLDVKKKFEDINQE 896
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI---INKYQIDLDEILEK 369
+ + K + + R ++ + AE+ SL E M ++ + K Q EIL
Sbjct: 897 FVKIKDKN--EILKRNLENTQNQIKAEY--ISLAEHEAKMSSLSQSMRKVQDSNAEILAN 952
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
Y K Q ++ +E+K+ ++L ++ + I+ + A + + ER + +
Sbjct: 953 YRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKYAPIVSFEECERKFKAT---------- 1001
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
E ELK+ L+++ K S + ++ ++ ++ K+I L L + L +E+E+
Sbjct: 1002 EKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL 1061
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEE---AHNEVKSLHEELTKLYK--SKVDENN 544
R K + +EE +E+ ++ L K + +V+
Sbjct: 1062 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1121
Query: 545 ANLN-LIKILSEEIDALKIAIAKNEEKMLSLSEK-DNKLTELVSTINGL--KEENNSLKS 600
+LN I+ L EE+ +++ K ++ + L + +N+ V L KE
Sbjct: 1122 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVG 1181
Query: 601 LNDVITREKETQA-------SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ REKE ++ S+L+ Q KQ +L+ + L
Sbjct: 1182 IIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1241
Query: 654 XXDEAKSLLEQNLALKEQCEE----KTRDCSR----------LEINIKTHEKTAEIQNRM 699
+E L N +E CEE K ++ S +E IK ++ +
Sbjct: 1242 SLNE--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
I LQ++IQE K K+ K+ EL N E LK+ + + +S + + D +
Sbjct: 1300 ITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1359
Query: 760 EGRIAELESDI 770
+ ++ LE +
Sbjct: 1360 QHQVKSLEQQL 1370
Score = 66.5 bits (155), Expect = 5e-10
Identities = 189/996 (18%), Positives = 410/996 (41%), Gaps = 85/996 (8%)
Query: 94 KYQNLI-LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN 152
++QN+ LE + DL +++ ++ E ++ L L + ++L+ E + L +
Sbjct: 292 EHQNIQDLEIENEDL-KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKS 350
Query: 153 LIMENVTESDNLNKEVDDLKKNNECLTQKCIDL-EKLVNESENKIGPKN--ICAQCKLKE 209
L+ + + + ++ LK + + N E+ + + A +
Sbjct: 351 LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS 410
Query: 210 NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNH 269
I + H+ + L L S+ S TS N+I L+ EL+A R C+ +D ++N
Sbjct: 411 PGIPA-HMQSRSMLRPLELSLP-SQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNE 466
Query: 270 ----------LELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQ 312
L L + D DE++ + + K M E ++ + +L E
Sbjct: 467 LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI---LMDN--IINKYQIDLDEIL 367
L + + + + KD L L ++ S +V ++ + N I+ +++ D +++
Sbjct: 527 LTSEAASGNHRLTEELKDQ-LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 585
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIV 427
E+ ++Q +L+ C E + K+ + Q E +A L I E+ + S+++ ++
Sbjct: 586 EENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL-SAKLALSIPAEKFENMKSSLSNEVN 644
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQ---DLPAHKKITILFDALITQYELSRTDYE 484
+K +L E+ + LS+++ + R+L+ L H K + + ++ E +
Sbjct: 645 EKAKKLVEMEREHEKSLSEIR-QLKRELENVKAKLAQHVK-PEEHEQVKSRLEQKSGELG 702
Query: 485 IEKEKLRLETGT-AKAVXXXXXXXXXXXXXXFD-TLEEAHNEVK-SLHEELTKLYKSKVD 541
+ +L L+ T K + + T+E ++ V + E++ K + + +D
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
Query: 542 E-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+ N L++ + +E+ ++ + +N+ SLS+ ++L + ++E +LKS
Sbjct: 763 DLNRKLLDVTQKYTEKKLEMEKLLLEND----SLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
N V E + Q SEL++ C ++ L ++ +E K
Sbjct: 819 -NIV---ELKKQLSELKKKCGEDQEKIHALTSENTNL----KKMMSNQYVPVKTHEEVKM 870
Query: 661 LLEQNLALKEQ----CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
L LA + ++K D ++ + IK EI R + Q QI+ + E
Sbjct: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN---EILKRNLENTQNQIKAEYISLAE 927
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E K++ L+ +++++ D+ + L + R+ ++ T + I + ++ T Q
Sbjct: 928 HEAKMSSLS---QSMRKVQDSNAEILANYRKGQEEIVT----LHAEIKAQKKELDTIQEC 980
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
D+ + + + + + + E +LK+
Sbjct: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK----NKQENDKLKKE 1036
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ + Q++L D K E E E L + ++ + K+ +V N+KE++ +
Sbjct: 1037 IFTLQKDLRD-KTVLIEKSHEMERA---LSRKTDELNKQLKDLSQKYTEVKNVKEKL-VE 1091
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+ ++ ++ V + L V + S + +E K +K+++ Y+K+ + T
Sbjct: 1092 ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRC-YEKE--QQT 1148
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
VTK+ + +E + E + E+ +K +E +EE + E + + + +
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
Query: 1017 KRLKEAKIAL---EIVD--KLSNQKVALEKQIESLS 1047
+ K+A L E+VD K K LE QI SL+
Sbjct: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1244
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/276 (18%), Positives = 125/276 (45%), Gaps = 21/276 (7%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+V++ K L C++ +D E+ K+L+D + + + E + + +++ L+L++ +++
Sbjct: 470 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTS 529
Query: 889 --------LKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE--VEKNK 937
L E+++ Q + ++ + + A V + + ++V+ D +E+NK
Sbjct: 530 EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK 589
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
RL K + +++ VT+M+ ++ + K ++ E+ K+ L E
Sbjct: 590 RLQKELSMCEMEREKKGRKVTEMEGQAKELSAK-LALSIPAEKFENMKSSLS------NE 642
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
++E+ + E ++ E+ +++ K LE V Q V E+ + S + +
Sbjct: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
Query: 1058 VATGSAIVQNQQITDVMKE---NQKLKKMNAKLITI 1090
++NQ + +++ + KL K A +TI
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Score = 44.4 bits (100), Expect = 0.002
Identities = 89/466 (19%), Positives = 196/466 (42%), Gaps = 55/466 (11%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+S + L L+ + K +C L + E+ E + I +L+ +++ K E E
Sbjct: 454 ESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYESE 510
Query: 719 TKLNELTNKYEALKRDY--DAAVKDLESSREAVNQLTTQKDLVEG---RIAELESDIRTE 773
K+ ++ + ALK +AA + + E +QL K EG + +L + I+
Sbjct: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG------ENPKLDDSPKRSISVISD 827
+ E G E + S K ++S+ ++
Sbjct: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
Query: 828 ----------SEVSQLKERLLSCQQE----LDDLKERYKELDDECETCAEYL--QERDEQ 871
+EV++ ++L+ ++E L ++++ +EL++ A+++ +E ++
Sbjct: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
Query: 872 CARLKKEKLSLEQQVSNLKEQIRT-QQPVER----QAKFADVAVNTDEDWANLH---SVV 923
+RL+++ L ++++ L + +T Q+ +E+ + A N + N + V
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
Query: 924 VD-RMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF---EAKR 978
D + S+DA ++ N++L+ ++ KK +++ + + + ++ + F E
Sbjct: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
KE+ K+ + ELK++ EL ++C E + + LK+ +SNQ V
Sbjct: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK---------MMSNQYVP 861
Query: 1039 LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ K E + T N T+ + ++ D+ +E K+K N
Sbjct: 862 V-KTHEEVKMT--LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
Score = 33.1 bits (72), Expect = 5.7
Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
IE + K + ++T ++ + ++ES+ +I K K++ L D++ K AL G Q
Sbjct: 1282 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQL 1341
Query: 98 LIL-------ETQTRDLLMSQIKSLEMENLTKDKE 125
++Q D L Q+KSLE + D++
Sbjct: 1342 TYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
>AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens cDNA
FLJ46736 fis, clone TRACH3020769, weakly similar to
Myosin heavy chain, nonmuscle type B. ).
Length = 1080
Score = 68.5 bits (160), Expect = 1e-10
Identities = 142/698 (20%), Positives = 284/698 (40%), Gaps = 72/698 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSAL---EGKYQNLILETQTRDLLMSQIKSLEMENLT 121
E ++ L L+ L EL +K + + Q + Q +L I + +L+
Sbjct: 385 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILT---NHLS 441
Query: 122 KDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQK 181
K KEI+ + +++ +E +++ ++++ E + L E+D +K N+ +K
Sbjct: 442 KQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAM---LRLEIDTIKNQNQEKEKK 498
Query: 182 CIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNK 241
C + K+V E + K I +E L Q++ Y+ LS L + N+ K
Sbjct: 499 CFEDLKIVKEKNEDL-QKTIKQN---EETLTQTIS-QYNGRLSVLTAENAMLNSKLENEK 553
Query: 242 ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSE 301
+ L+A E ++ E + + + E + + K +S
Sbjct: 554 --QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSN 611
Query: 302 IKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
+K N LS+QL ESK + I+ + DA +L + + D +++ Q
Sbjct: 612 LKDNNEILSQQLFKTESKLNSLEIEFHHTR-----DA-LREKTLGLERVQKD--LSQTQC 663
Query: 362 DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-------QLIEKENACN-----ILR 409
+ E+ +KY Q +N+ + +SV E+L+ L S QL + N + ++
Sbjct: 664 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 723
Query: 410 IQKERIHEISSAVTIDIVKKE---NELKEILTKECLKLSKLKID----------IPRDLD 456
IQ ++ H I + + K+ E + L EC L + + + R L
Sbjct: 724 IQ-DQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 782
Query: 457 QDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
Q+L K + +A + R + E E + L+ + G + +
Sbjct: 783 QELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAE 842
Query: 517 TLEEAHNEVKSLHEEL---TKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
+++ +++ + +L K K++E NL + +E + LK + + +
Sbjct: 843 KMQDHKQKLEKDNAKLKVTIKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECN 902
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ-VIKQNGFELD- 631
L ++ K EL I G K N LK +TR+K + E S +K + FE+D
Sbjct: 903 LGQEMKKNVELEREITGFK---NLLK-----MTRKKLNEYENGEFSFHGDLKTSQFEMDI 954
Query: 632 ---KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALK---EQCEEKTRDCSRLE-- 683
K+K I + + L E+ L++K ++CE+ ++ +LE
Sbjct: 955 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQE 1014
Query: 684 -INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
IN+++H + ++ + + +++I+E + I ++ K
Sbjct: 1015 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLK 1052
Score = 66.5 bits (155), Expect = 5e-10
Identities = 171/905 (18%), Positives = 361/905 (39%), Gaps = 87/905 (9%)
Query: 250 DAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
D GR K+ + +KN ++ +MD + L +++E ++ ++ +N L
Sbjct: 216 DEGRPT-KKTSNEKNKVKNQIQ------SMDDVDDLTQSSETASEDCELPHSSYKNFMLL 268
Query: 310 SEQLINNESKKSKDHIDRYKDSLLA---VLDAEFGTTSLDVFEIL-MDNIINKYQIDLDE 365
EQL E K S + + +D+ L+ +L+ + L +I M++ +N Q +L E
Sbjct: 269 IEQL-GMECKDSVSLL-KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE 326
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
E ++++ E EL S+ SLN + ++ NA + +E++ +
Sbjct: 327 TKEIKSQLEHQKVEWERELCSLR---FSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKE 383
Query: 426 I-VKKENELKEILTKECLKLSKLKIDIPR------DLDQDLPAHKKITILFDALITQYEL 478
+ VK++ EL + T E ++L +K ++ + D + L + +L D ++T +
Sbjct: 384 VEVKQQLELS-LQTLE-MELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLS 441
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
+ + E+ ++K+ E + + ++ ++ L EE+ L +
Sbjct: 442 KQKEIEMAQKKMNSENSHSH-----------------EEEKDLSHKNSMLQEEIAML-RL 483
Query: 539 KVDE-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING----LKE 593
++D N N K E+ LKI KNE+ ++ + + LT+ +S NG L
Sbjct: 484 EIDTIKNQNQEKEKKCFED---LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTA 540
Query: 594 ENNSLKSLNDVITREKETQASELER-----SCQVIKQNGFELDKMKADILMXXXXXXXXX 648
EN L S + + KE +E+E + + ++ E K + ++
Sbjct: 541 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSR 600
Query: 649 XXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI-----KTHEKTAEIQ--NRMIM 701
D +L + N L +Q + + LEI EKT ++ + +
Sbjct: 601 LQDKMNFD-VSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 659
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
+ Q Q++E ++ + ++ K+N+ K E+++ + R+ ++ + D E
Sbjct: 660 QTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEK 719
Query: 762 RIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK-------- 813
+ ++ E + EN K
Sbjct: 720 TVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVR 779
Query: 814 -LDDSPKRSISVISDSEVS-QLKERL-LSCQQELDDLKERYKELDDECETCAEYLQERDE 870
L ++ S SE S ++ R ++ + E DLK++ ++ ++ + + E
Sbjct: 780 QLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR 839
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
+++ K LE+ + LK I+ Q + + + N ED +++ +
Sbjct: 840 CAEKMQDHKQKLEKDNAKLKVTIKKQMDKIEELQKNLLNANLSEDEKEQLKKLME-LKQS 898
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELE 989
E + + K + EL + KN + +K + +Y + F K + + ++
Sbjct: 899 LECNLGQEMKKNV-ELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQIN 957
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIV----DKLSNQKVALEKQIES 1045
+LK + +L E ET + + + L+E ++++ V +KL K LE+++ +
Sbjct: 958 KLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN 1017
Query: 1046 LSNTPVSNSTMYVATGSAIVQNQQITDVMKEN--QKLKKMNAKLITICKKRGKTGANREN 1103
L + N V G Q+I + ++ +KLK++N L + RE
Sbjct: 1018 LRSHIERN---MVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQLREK 1074
Query: 1104 EDPSD 1108
+D D
Sbjct: 1075 QDLPD 1079
Score = 44.0 bits (99), Expect = 0.003
Identities = 77/364 (21%), Positives = 163/364 (44%), Gaps = 50/364 (13%)
Query: 46 KLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL----FDIKEQKSALEGKYQNLILE 101
+LQD +S +LK+++ ++ +L K +L + + AL K L LE
Sbjct: 600 RLQDKMNFDVS-----NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK--TLGLE 652
Query: 102 TQTRDLLMSQIKSLEMENLTKDKEIK--NLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
+DL +Q + EME +++++K ++ +++++LQ EN L + +
Sbjct: 653 RVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN 712
Query: 160 ESDNLNKEVDDLKKNNECLTQKC---IDLEKLVNESENKIGPKNICAQCK-LKENLIQSL 215
++DN K V +++ + QK + + L+ E N K + ++C LKE Q
Sbjct: 713 KADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERN----KELISECNHLKERQYQ-- 766
Query: 216 HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEP 275
Y+N K R + + LQ EL A + + E + + ++
Sbjct: 767 ---YEN--EKAEREV----------VVRQLQQEL-ADTLKKQSMSEASLEVTSRYRINLE 810
Query: 276 NMTMDLDEKLGE-NNEFE------TKAVKVMSEIKRNLNSLSEQLINNESKKS-KDHIDR 327
+ T DL +KLG+ N+ + T+AV+ +++ + L + N + K + K +D+
Sbjct: 811 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD--NAKLKVTIKKQMDK 868
Query: 328 YKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSV 387
++ +L+A + + LM+ + + +L + ++K +++ ++ + LK
Sbjct: 869 IEELQKNLLNANLSEDEKEQLKKLME-LKQSLECNLGQEMKKNVELEREITGFKNLLKMT 927
Query: 388 NEKL 391
+KL
Sbjct: 928 RKKL 931
>AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein.
Length = 1416
Score = 68.5 bits (160), Expect = 1e-10
Identities = 186/997 (18%), Positives = 390/997 (39%), Gaps = 101/997 (10%)
Query: 66 SSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S NEI K LE + K+ + L+ + + + E + L ++K D+
Sbjct: 437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE------DSDE 490
Query: 125 EIKNLTDSLKTKSKKINELQ---EENDTLSNLIMENVTE--SDNLNKEVDDLKKNNECLT 179
+IK L D+LK K++ E + ++ T + E++T + ++ ++LK + L
Sbjct: 491 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
K V + N+I + + + K + + I + L K S+ + +
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVE-EFKRD--EGKLIEENKRLQK-ELSMCEMEREKKG 606
Query: 240 NKICTLQSELD--AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
K+ ++ + + + E F ++K+ L N + +KL E K++
Sbjct: 607 RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLS 662
Query: 298 VMSEIKRNLNSLSEQLINN----ESKKSKDHIDRYKDSL---LAVLDAEFGTTSLDVFEI 350
+ ++KR L ++ +L + E ++ K +++ L + L + T ++ ++
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Query: 351 LMDNIINKYQID--LDEILEKYT--KVQGDLNECTSEL-KSVNEKLASLNSQLIEKENAC 405
+DN + K Q E+ Y KV D+ + + +N KL + + EK+
Sbjct: 723 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEM 782
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKEC----LK--LSKLKIDIPRDLDQDL 459
L ++ + + + S + V E KEI+ + LK LS+LK D ++
Sbjct: 783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 842
Query: 460 PAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
+ T L + QY +T E+ K+ L AK T
Sbjct: 843 ALTSENTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAK------------------TNR 881
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
E +VK E++ + + D+N ++ +I A I++A++E KM SLS+
Sbjct: 882 ELL-DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR 940
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELE----RSCQVIKQN---GFEL-- 630
K+ + + I N K +++T E +A + E + C +K FE
Sbjct: 941 KVQDSNAEILA-----NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 995
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
K KA +E K ++N LK++ +D + I+
Sbjct: 996 RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
+ +R L KQ+++ + + E + +L + + A L+ +
Sbjct: 1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLE 1115
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q+ K + G I L+ ++++ Q + + L E
Sbjct: 1116 QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK-------NSSVPLAE 1168
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ ++ ++ ++ + +I S L+E+ Q +++++ + E+ + + +
Sbjct: 1169 HLQIKEAFEKEVGIIKAS----LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV 1224
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
++ K K LE Q+S+L E++ K+ +V LH+ +
Sbjct: 1225 DLSKYKATKSDLETQISSLNEKL-----ANLNRKYEEVCEEV------LHA---KKKEIS 1270
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
A+ EK +E++ +K+ ++T + + + + K+ EAK ++ + ++E
Sbjct: 1271 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1330
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
LKQ L + T K++ + L+ +LE
Sbjct: 1331 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLE 1367
Score = 66.9 bits (156), Expect = 4e-10
Identities = 161/791 (20%), Positives = 318/791 (40%), Gaps = 74/791 (9%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKES-SNEINLKLEKL-------SGELF 82
+ K + E + +L ++I + +++K S SNE+N K +KL L
Sbjct: 603 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLS 662
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKKIN 141
+I++ K LE L + + Q+KS LE ++ K+I LT +T K+I
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEE--HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
Query: 142 ELQEENDTLSNLIMENVTESDNLN---KEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
++ +N L E N K +D+KK+++ + DL + + + K
Sbjct: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID---DLNRKLLDVTQKYTE 777
Query: 199 KNICAQCKLKENLIQSLHIGYDNTL----SKLNRSIS--DSNTSTRYNKICTLQSELDAG 252
K + + L EN S + T+ K + I SN ++ L+ +
Sbjct: 778 KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGED 837
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
+E L + T++K + + + K+ N+ K + + ++K+ ++++
Sbjct: 838 QEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL-AKTNRELLDVKKKFEDINQE 896
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI---INKYQIDLDEILEK 369
+ + K + + R ++ + AE+ SL E M ++ + K Q EIL
Sbjct: 897 FVKIKDKN--EILKRNLENTQNQIKAEY--ISLAEHEAKMSSLSQSMRKVQDSNAEILAN 952
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
Y K Q ++ +E+K+ ++L ++ + I+ + A + + ER + +
Sbjct: 953 YRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKYAPIVSFEECERKFKAT---------- 1001
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
E ELK+ L+++ K S + ++ ++ ++ K+I L L + L +E+E+
Sbjct: 1002 EKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL 1061
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEE---AHNEVKSLHEELTKLYK--SKVDENN 544
R K + +EE +E+ ++ L K + +V+
Sbjct: 1062 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1121
Query: 545 ANLN-LIKILSEEIDALKIAIAKNEEKMLSLSEK-DNKLTELVSTINGL--KEENNSLKS 600
+LN I+ L EE+ +++ K ++ + L + +N+ V L KE
Sbjct: 1122 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVG 1181
Query: 601 LNDVITREKETQA-------SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ REKE ++ S+L+ Q KQ +L+ + L
Sbjct: 1182 IIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1241
Query: 654 XXDEAKSLLEQNLALKEQCEE----KTRDCSR----------LEINIKTHEKTAEIQNRM 699
+E L N +E CEE K ++ S +E IK ++ +
Sbjct: 1242 SLNE--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
I LQ++IQE K K+ K+ EL N E LK+ + + +S + + D +
Sbjct: 1300 ITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1359
Query: 760 EGRIAELESDI 770
+ ++ LE +
Sbjct: 1360 QHQVKSLEQQL 1370
Score = 66.5 bits (155), Expect = 5e-10
Identities = 189/996 (18%), Positives = 410/996 (41%), Gaps = 85/996 (8%)
Query: 94 KYQNLI-LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN 152
++QN+ LE + DL +++ ++ E ++ L L + ++L+ E + L +
Sbjct: 292 EHQNIQDLEIENEDL-KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKS 350
Query: 153 LIMENVTESDNLNKEVDDLKKNNECLTQKCIDL-EKLVNESENKIGPKN--ICAQCKLKE 209
L+ + + + ++ LK + + N E+ + + A +
Sbjct: 351 LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS 410
Query: 210 NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNH 269
I + H+ + L L S+ S TS N+I L+ EL+A R C+ +D ++N
Sbjct: 411 PGIPA-HMQSRSMLRPLELSLP-SQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNE 466
Query: 270 ----------LELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQ 312
L L + D DE++ + + K M E ++ + +L E
Sbjct: 467 LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI---LMDN--IINKYQIDLDEIL 367
L + + + + KD L L ++ S +V ++ + N I+ +++ D +++
Sbjct: 527 LTSEAASGNHRLTEELKDQ-LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 585
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIV 427
E+ ++Q +L+ C E + K+ + Q E +A L I E+ + S+++ ++
Sbjct: 586 EENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL-SAKLALSIPAEKFENMKSSLSNEVN 644
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQ---DLPAHKKITILFDALITQYELSRTDYE 484
+K +L E+ + LS+++ + R+L+ L H K + + ++ E +
Sbjct: 645 EKAKKLVEMEREHEKSLSEIR-QLKRELENVKAKLAQHVK-PEEHEQVKSRLEQKSGELG 702
Query: 485 IEKEKLRLETGT-AKAVXXXXXXXXXXXXXXFD-TLEEAHNEVK-SLHEELTKLYKSKVD 541
+ +L L+ T K + + T+E ++ V + E++ K + + +D
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
Query: 542 E-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+ N L++ + +E+ ++ + +N+ SLS+ ++L + ++E +LKS
Sbjct: 763 DLNRKLLDVTQKYTEKKLEMEKLLLEND----SLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
N V E + Q SEL++ C ++ L ++ +E K
Sbjct: 819 -NIV---ELKKQLSELKKKCGEDQEKIHALTSENTNL----KKMMSNQYVPVKTHEEVKM 870
Query: 661 LLEQNLALKEQ----CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
L LA + ++K D ++ + IK EI R + Q QI+ + E
Sbjct: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN---EILKRNLENTQNQIKAEYISLAE 927
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E K++ L+ +++++ D+ + L + R+ ++ T + I + ++ T Q
Sbjct: 928 HEAKMSSLS---QSMRKVQDSNAEILANYRKGQEEIVT----LHAEIKAQKKELDTIQEC 980
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
D+ + + + + + + E +LK+
Sbjct: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK----NKQENDKLKKE 1036
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ + Q++L D K E E E L + ++ + K+ +V N+KE++ +
Sbjct: 1037 IFTLQKDLRD-KTVLIEKSHEMERA---LSRKTDELNKQLKDLSQKYTEVKNVKEKL-VE 1091
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+ ++ ++ V + L V + S + +E K +K+++ Y+K+ + T
Sbjct: 1092 ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRC-YEKE--QQT 1148
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
VTK+ + +E + E + E+ +K +E +EE + E + + + +
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
Query: 1017 KRLKEAKIAL---EIVD--KLSNQKVALEKQIESLS 1047
+ K+A L E+VD K K LE QI SL+
Sbjct: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1244
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/276 (18%), Positives = 125/276 (45%), Gaps = 21/276 (7%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+V++ K L C++ +D E+ K+L+D + + + E + + +++ L+L++ +++
Sbjct: 470 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTS 529
Query: 889 --------LKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE--VEKNK 937
L E+++ Q + ++ + + A V + + ++V+ D +E+NK
Sbjct: 530 EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK 589
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
RL K + +++ VT+M+ ++ + K ++ E+ K+ L E
Sbjct: 590 RLQKELSMCEMEREKKGRKVTEMEGQAKELSAK-LALSIPAEKFENMKSSLS------NE 642
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
++E+ + E ++ E+ +++ K LE V Q V E+ + S + +
Sbjct: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
Query: 1058 VATGSAIVQNQQITDVMKE---NQKLKKMNAKLITI 1090
++NQ + +++ + KL K A +TI
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Score = 44.4 bits (100), Expect = 0.002
Identities = 89/466 (19%), Positives = 196/466 (42%), Gaps = 55/466 (11%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+S + L L+ + K +C L + E+ E + I +L+ +++ K E E
Sbjct: 454 ESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYESE 510
Query: 719 TKLNELTNKYEALKRDY--DAAVKDLESSREAVNQLTTQKDLVEG---RIAELESDIRTE 773
K+ ++ + ALK +AA + + E +QL K EG + +L + I+
Sbjct: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG------ENPKLDDSPKRSISVISD 827
+ E G E + S K ++S+ ++
Sbjct: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
Query: 828 ----------SEVSQLKERLLSCQQE----LDDLKERYKELDDECETCAEYL--QERDEQ 871
+EV++ ++L+ ++E L ++++ +EL++ A+++ +E ++
Sbjct: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
Query: 872 CARLKKEKLSLEQQVSNLKEQIRT-QQPVER----QAKFADVAVNTDEDWANLH---SVV 923
+RL+++ L ++++ L + +T Q+ +E+ + A N + N + V
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
Query: 924 VD-RMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF---EAKR 978
D + S+DA ++ N++L+ ++ KK +++ + + + ++ + F E
Sbjct: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
KE+ K+ + ELK++ EL ++C E + + LK+ +SNQ V
Sbjct: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK---------MMSNQYVP 861
Query: 1039 LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ K E + T N T+ + ++ D+ +E K+K N
Sbjct: 862 V-KTHEEVKMT--LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
Score = 33.1 bits (72), Expect = 5.7
Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
IE + K + ++T ++ + ++ES+ +I K K++ L D++ K AL G Q
Sbjct: 1282 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQL 1341
Query: 98 LIL-------ETQTRDLLMSQIKSLEMENLTKDKE 125
++Q D L Q+KSLE + D++
Sbjct: 1342 TYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
>AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein.
Length = 1416
Score = 68.5 bits (160), Expect = 1e-10
Identities = 186/997 (18%), Positives = 390/997 (39%), Gaps = 101/997 (10%)
Query: 66 SSNEINLK-LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S NEI K LE + K+ + L+ + + + E + L ++K D+
Sbjct: 437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE------DSDE 490
Query: 125 EIKNLTDSLKTKSKKINELQ---EENDTLSNLIMENVTE--SDNLNKEVDDLKKNNECLT 179
+IK L D+LK K++ E + ++ T + E++T + ++ ++LK + L
Sbjct: 491 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
K V + N+I + + + K + + I + L K S+ + +
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVE-EFKRD--EGKLIEENKRLQK-ELSMCEMEREKKG 606
Query: 240 NKICTLQSELD--AGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
K+ ++ + + + E F ++K+ L N + +KL E K++
Sbjct: 607 RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS----NEVNEKAKKLVEMEREHEKSLS 662
Query: 298 VMSEIKRNLNSLSEQLINN----ESKKSKDHIDRYKDSL---LAVLDAEFGTTSLDVFEI 350
+ ++KR L ++ +L + E ++ K +++ L + L + T ++ ++
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Query: 351 LMDNIINKYQID--LDEILEKYT--KVQGDLNECTSEL-KSVNEKLASLNSQLIEKENAC 405
+DN + K Q E+ Y KV D+ + + +N KL + + EK+
Sbjct: 723 YLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEM 782
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKEC----LK--LSKLKIDIPRDLDQDL 459
L ++ + + + S + V E KEI+ + LK LS+LK D ++
Sbjct: 783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 842
Query: 460 PAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
+ T L + QY +T E+ K+ L AK T
Sbjct: 843 ALTSENTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAK------------------TNR 881
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN 579
E +VK E++ + + D+N ++ +I A I++A++E KM SLS+
Sbjct: 882 ELL-DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR 940
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELE----RSCQVIKQN---GFEL-- 630
K+ + + I N K +++T E +A + E + C +K FE
Sbjct: 941 KVQDSNAEILA-----NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 995
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
K KA +E K ++N LK++ +D + I+
Sbjct: 996 RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
+ +R L KQ+++ + + E + +L + + A L+ +
Sbjct: 1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLE 1115
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q+ K + G I L+ ++++ Q + + L E
Sbjct: 1116 QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK-------NSSVPLAE 1168
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ ++ ++ ++ + +I S L+E+ Q +++++ + E+ + + +
Sbjct: 1169 HLQIKEAFEKEVGIIKAS----LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV 1224
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
++ K K LE Q+S+L E++ K+ +V LH+ +
Sbjct: 1225 DLSKYKATKSDLETQISSLNEKL-----ANLNRKYEEVCEEV------LHA---KKKEIS 1270
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
A+ EK +E++ +K+ ++T + + + + K+ EAK ++ + ++E
Sbjct: 1271 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1330
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
LKQ L + T K++ + L+ +LE
Sbjct: 1331 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLE 1367
Score = 66.9 bits (156), Expect = 4e-10
Identities = 161/791 (20%), Positives = 318/791 (40%), Gaps = 74/791 (9%)
Query: 31 KSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKES-SNEINLKLEKL-------SGELF 82
+ K + E + +L ++I + +++K S SNE+N K +KL L
Sbjct: 603 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLS 662
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKKIN 141
+I++ K LE L + + Q+KS LE ++ K+I LT +T K+I
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEE--HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
Query: 142 ELQEENDTLSNLIMENVTESDNLN---KEVDDLKKNNECLTQKCIDLEKLVNESENKIGP 198
++ +N L E N K +D+KK+++ + DL + + + K
Sbjct: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID---DLNRKLLDVTQKYTE 777
Query: 199 KNICAQCKLKENLIQSLHIGYDNTL----SKLNRSIS--DSNTSTRYNKICTLQSELDAG 252
K + + L EN S + T+ K + I SN ++ L+ +
Sbjct: 778 KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGED 837
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
+E L + T++K + + + K+ N+ K + + ++K+ ++++
Sbjct: 838 QEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL-AKTNRELLDVKKKFEDINQE 896
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI---INKYQIDLDEILEK 369
+ + K + + R ++ + AE+ SL E M ++ + K Q EIL
Sbjct: 897 FVKIKDKN--EILKRNLENTQNQIKAEY--ISLAEHEAKMSSLSQSMRKVQDSNAEILAN 952
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
Y K Q ++ +E+K+ ++L ++ + I+ + A + + ER + +
Sbjct: 953 YRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKYAPIVSFEECERKFKAT---------- 1001
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
E ELK+ L+++ K S + ++ ++ ++ K+I L L + L +E+E+
Sbjct: 1002 EKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL 1061
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXFDTLEE---AHNEVKSLHEELTKLYK--SKVDENN 544
R K + +EE +E+ ++ L K + +V+
Sbjct: 1062 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1121
Query: 545 ANLN-LIKILSEEIDALKIAIAKNEEKMLSLSEK-DNKLTELVSTINGL--KEENNSLKS 600
+LN I+ L EE+ +++ K ++ + L + +N+ V L KE
Sbjct: 1122 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVG 1181
Query: 601 LNDVITREKETQA-------SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ REKE ++ S+L+ Q KQ +L+ + L
Sbjct: 1182 IIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1241
Query: 654 XXDEAKSLLEQNLALKEQCEE----KTRDCSR----------LEINIKTHEKTAEIQNRM 699
+E L N +E CEE K ++ S +E IK ++ +
Sbjct: 1242 SLNE--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
I LQ++IQE K K+ K+ EL N E LK+ + + +S + + D +
Sbjct: 1300 ITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1359
Query: 760 EGRIAELESDI 770
+ ++ LE +
Sbjct: 1360 QHQVKSLEQQL 1370
Score = 66.5 bits (155), Expect = 5e-10
Identities = 189/996 (18%), Positives = 410/996 (41%), Gaps = 85/996 (8%)
Query: 94 KYQNLI-LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN 152
++QN+ LE + DL +++ ++ E ++ L L + ++L+ E + L +
Sbjct: 292 EHQNIQDLEIENEDL-KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKS 350
Query: 153 LIMENVTESDNLNKEVDDLKKNNECLTQKCIDL-EKLVNESENKIGPKN--ICAQCKLKE 209
L+ + + + ++ LK + + N E+ + + A +
Sbjct: 351 LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS 410
Query: 210 NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNH 269
I + H+ + L L S+ S TS N+I L+ EL+A R C+ +D ++N
Sbjct: 411 PGIPA-HMQSRSMLRPLELSLP-SQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNE 466
Query: 270 ----------LELHEPNMTMDLDEKLGENNEFETKAVKVMSE-------IKRNLNSLSEQ 312
L L + D DE++ + + K M E ++ + +L E
Sbjct: 467 LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
Query: 313 LINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI---LMDN--IINKYQIDLDEIL 367
L + + + + KD L L ++ S +V ++ + N I+ +++ D +++
Sbjct: 527 LTSEAASGNHRLTEELKDQ-LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 585
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIV 427
E+ ++Q +L+ C E + K+ + Q E +A L I E+ + S+++ ++
Sbjct: 586 EENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL-SAKLALSIPAEKFENMKSSLSNEVN 644
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQ---DLPAHKKITILFDALITQYELSRTDYE 484
+K +L E+ + LS+++ + R+L+ L H K + + ++ E +
Sbjct: 645 EKAKKLVEMEREHEKSLSEIR-QLKRELENVKAKLAQHVK-PEEHEQVKSRLEQKSGELG 702
Query: 485 IEKEKLRLETGT-AKAVXXXXXXXXXXXXXXFD-TLEEAHNEVK-SLHEELTKLYKSKVD 541
+ +L L+ T K + + T+E ++ V + E++ K + + +D
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
Query: 542 E-NNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+ N L++ + +E+ ++ + +N+ SLS+ ++L + ++E +LKS
Sbjct: 763 DLNRKLLDVTQKYTEKKLEMEKLLLEND----SLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
N V E + Q SEL++ C ++ L ++ +E K
Sbjct: 819 -NIV---ELKKQLSELKKKCGEDQEKIHALTSENTNL----KKMMSNQYVPVKTHEEVKM 870
Query: 661 LLEQNLALKEQ----CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
L LA + ++K D ++ + IK EI R + Q QI+ + E
Sbjct: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN---EILKRNLENTQNQIKAEYISLAE 927
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E K++ L+ +++++ D+ + L + R+ ++ T + I + ++ T Q
Sbjct: 928 HEAKMSSLS---QSMRKVQDSNAEILANYRKGQEEIVT----LHAEIKAQKKELDTIQEC 980
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
D+ + + + + + + E +LK+
Sbjct: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK----NKQENDKLKKE 1036
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+ + Q++L D K E E E L + ++ + K+ +V N+KE++ +
Sbjct: 1037 IFTLQKDLRD-KTVLIEKSHEMERA---LSRKTDELNKQLKDLSQKYTEVKNVKEKL-VE 1091
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+ ++ ++ V + L V + S + +E K +K+++ Y+K+ + T
Sbjct: 1092 ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRC-YEKE--QQT 1148
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
VTK+ + +E + E + E+ +K +E +EE + E + + + +
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
Query: 1017 KRLKEAKIAL---EIVD--KLSNQKVALEKQIESLS 1047
+ K+A L E+VD K K LE QI SL+
Sbjct: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1244
Score = 49.2 bits (112), Expect = 8e-05
Identities = 52/276 (18%), Positives = 125/276 (45%), Gaps = 21/276 (7%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+V++ K L C++ +D E+ K+L+D + + + E + + +++ L+L++ +++
Sbjct: 470 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTS 529
Query: 889 --------LKEQIRTQ-QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE--VEKNK 937
L E+++ Q + ++ + + A V + + ++V+ D +E+NK
Sbjct: 530 EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK 589
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
RL K + +++ VT+M+ ++ + K ++ E+ K+ L E
Sbjct: 590 RLQKELSMCEMEREKKGRKVTEMEGQAKELSAK-LALSIPAEKFENMKSSLS------NE 642
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
++E+ + E ++ E+ +++ K LE V Q V E+ + S + +
Sbjct: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
Query: 1058 VATGSAIVQNQQITDVMKE---NQKLKKMNAKLITI 1090
++NQ + +++ + KL K A +TI
Sbjct: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Score = 44.4 bits (100), Expect = 0.002
Identities = 89/466 (19%), Positives = 196/466 (42%), Gaps = 55/466 (11%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+S + L L+ + K +C L + E+ E + I +L+ +++ K E E
Sbjct: 454 ESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYESE 510
Query: 719 TKLNELTNKYEALKRDY--DAAVKDLESSREAVNQLTTQKDLVEG---RIAELESDIRTE 773
K+ ++ + ALK +AA + + E +QL K EG + +L + I+
Sbjct: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG------ENPKLDDSPKRSISVISD 827
+ E G E + S K ++S+ ++
Sbjct: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
Query: 828 ----------SEVSQLKERLLSCQQE----LDDLKERYKELDDECETCAEYL--QERDEQ 871
+EV++ ++L+ ++E L ++++ +EL++ A+++ +E ++
Sbjct: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
Query: 872 CARLKKEKLSLEQQVSNLKEQIRT-QQPVER----QAKFADVAVNTDEDWANLH---SVV 923
+RL+++ L ++++ L + +T Q+ +E+ + A N + N + V
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
Query: 924 VD-RMSYDAEVEK-NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF---EAKR 978
D + S+DA ++ N++L+ ++ KK +++ + + + ++ + F E
Sbjct: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
KE+ K+ + ELK++ EL ++C E + + LK+ +SNQ V
Sbjct: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK---------MMSNQYVP 861
Query: 1039 LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMN 1084
+ K E + T N T+ + ++ D+ +E K+K N
Sbjct: 862 V-KTHEEVKMT--LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
Score = 33.1 bits (72), Expect = 5.7
Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
IE + K + ++T ++ + ++ES+ +I K K++ L D++ K AL G Q
Sbjct: 1282 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQL 1341
Query: 98 LIL-------ETQTRDLLMSQIKSLEMENLTKDKE 125
++Q D L Q+KSLE + D++
Sbjct: 1342 TYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQ 1376
>DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein.
Length = 2479
Score = 67.7 bits (158), Expect = 2e-10
Identities = 210/1069 (19%), Positives = 444/1069 (41%), Gaps = 103/1069 (9%)
Query: 48 QDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI-LETQTR- 105
QD+ + + +L+ S+E+ L + S ++ ++ + +L +Y L+ LE Q R
Sbjct: 853 QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912
Query: 106 --DLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDN 163
+ +++ S+E E K ++ + K + ++ + + +LS L + N ++
Sbjct: 913 ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 972
Query: 164 LNKEVDDLKKNNECLTQKCIDLEKLVNESEN-KIGPKNICAQCKL-KENLI-------QS 214
K D L+K+N L Q+ +LE L E+ + K ++I + ++ KE L Q
Sbjct: 973 TAKYRDILQKDN-MLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031
Query: 215 LHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ-SELDAGR--EDCKELCEDF-TSIKN-- 268
+G ++++ K +SI++S+ + KI L+ EL+ + E C+++ E TS+K
Sbjct: 1032 TKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQME 1091
Query: 269 ----HLELHEPNMT-MDLDEKLGEN---NEFETKAVKVMSEIKRN-LNSLSEQLINNESK 319
LE +T ++LD + E +E K +S+ R + L + + + +
Sbjct: 1092 ERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVE 1151
Query: 320 KSK-DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTK--VQGD 376
SK I + +L+A+ + +V + M + + Q D ++ K + V
Sbjct: 1152 VSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQ 1211
Query: 377 LNECTS--ELKSVNEKLAS-------LNSQLIEKENACNILRIQ-KERIHEISSAVTIDI 426
L+E T+ +L+S+ KL L +L EKE A R++ + R + TI
Sbjct: 1212 LSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ--TIQS 1269
Query: 427 VKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIE 486
++++ L ++ K SK I + D K+ I+ + +Q E + +
Sbjct: 1270 LRRQFSGALPLAQQ-EKFSKTMIQLQND---------KLKIMQEMKNSQQEHRNMENKTL 1319
Query: 487 KEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ +L+L+ G + + + +EE + L+ EL K K ++ N
Sbjct: 1320 EMELKLK-GLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK-DKEEIKYLN- 1376
Query: 546 NLNLIKILSEEIDALKIAIAK----NEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSL 601
N+I I +L+ I + +EE+ ++ +++ L + + +++N L +
Sbjct: 1377 --NIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFD--RQQNEILNAA 1432
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADI--LMXXXXXXXXXXXXXXXXDEAK 659
+ +E S + S + Q L K+K +I ++ + A
Sbjct: 1433 Q----KFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESAL 1488
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI-QNRMIMRLQKQIQEDDKLFIEKE 718
L EQN+ +++ + R RL + + AE+ + M + ++ + +
Sbjct: 1489 RLAEQNILSRDKVINELR--LRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQ 1546
Query: 719 TKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI---RTEQT 775
+LN+ K E LK+ K E RE V + ++ R+ EL++D + +QT
Sbjct: 1547 ARLNQ---KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL-ELQADSSLNKFKQT 1602
Query: 776 A--TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG------ENPKLDDSPKRSISVISD 827
A + T +++ L + D +R I+ +
Sbjct: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
Query: 828 SEVSQLK--------ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
E +K + + + E++DLK + E + LQ + E A +
Sbjct: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKE--ANSRAPT 1720
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
++ V LK Q+ ++ ++ A + + + A ++ +A + + +
Sbjct: 1721 TTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIV 1780
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
+ EL+ + +DL + K+++A++ T K++E + L D EL++ ++ Y ++
Sbjct: 1781 DRHTRELKTQVEDLNENLLKLKEALK--TSKNRE-NSLTDNLNDLNNELQKKQKAYNKIL 1837
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
E E + + + Q KRL + D + L+++++ L N
Sbjct: 1838 REKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLEN 1886
Score = 67.3 bits (157), Expect = 3e-10
Identities = 200/997 (20%), Positives = 421/997 (42%), Gaps = 120/997 (12%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSL-KESSNEINLKLEKL--SGE---LFD--IKEQ 87
++ + + N +K + + ++ QSL K + E+ L LE++ +GE F+ +K +
Sbjct: 31 SLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTK 90
Query: 88 KSALEGKYQNLILETQTRD--LLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
LE + + RD L ++I LE + KD+E++++ L+ K KK+NE
Sbjct: 91 VMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELE-KEKKVNEQL- 148
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI----GPKNI 201
L N EN E+ L +E LKK NE L Q ID +K ++ + + G +
Sbjct: 149 ---ALRNEEAEN--ENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSD 203
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
K+N ++ TL++ N I N R N L+ ++ +++ +
Sbjct: 204 YRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN--------LEESVQEMEKMTD 255
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
++ +K +H+ + +D +K EN+ ++ + V+ ++++ ++ N + ++ + K
Sbjct: 256 EYNRMK--AIVHQTDNVIDQLKK--ENDHYQLQ-VQELTDLLKSKNEEDDPIMVAVNAK- 309
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNEC 380
++ +K +L+ D E + ++ ++ N+ K + LD +Q + E
Sbjct: 310 ---VEEWK-LILSSKDDE-----IIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER 360
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
S++K + E++ ++ ++N C I+ K + A T+ ++ +K T +
Sbjct: 361 DSQIKMLTEQVEQYTKEM--EKNTC-IIEDLKNELQRNKGASTL---SQQTHMKIQSTLD 414
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAV 500
LK + + +L + A +K L +AL + Y +E + ++
Sbjct: 415 ILKEKTKEAERTAEL-AEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCK---- 469
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL---YKSKVDENNANLNLIKILSEE- 556
+ ++ E++ L +E+ KL +DEN A + + +
Sbjct: 470 ---------------NQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTM 514
Query: 557 IDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE--KETQAS 614
ID + +K+ ++ +E N++ L+ I L+EE LK + +E K + S
Sbjct: 515 IDLTEFRNSKHLKQQQYRAE--NQI--LLKEIESLEEERLDLKKKIRQMAQERGKRSATS 570
Query: 615 ELERSCQVIKQN---GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQ 671
L + +N G + + K D+L L + L KE+
Sbjct: 571 GLTTEDLNLTENISQGDRISERKLDLL---------SLKNMSEAQSKNEFLSRELIEKER 621
Query: 672 CEEKTRDCSRLEINIKTHEKTAEI--QNRMIMRLQKQI-QEDDKLFIEKETKLNELTNKY 728
E++R + K K E+ +N+ + K+I Q ++ + + K E +
Sbjct: 622 DLERSR-----TVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLII 676
Query: 729 EALKRDYDA-AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
+L+R +A K+ E +A L Q D + GR EL ++R + +
Sbjct: 677 PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736
Query: 788 XXXXXXXXXXXXTFGDENRDLGENP--KLDDSPKRSISVISDSEVSQLKERLLSCQQELD 845
+ G N K D P I+ S S ++ E L+ QEL+
Sbjct: 737 NLKIDHLEKETSLL---RQSEGSNVVFKGIDLPD-GIAPSSASIINSQNEYLIHLLQELE 792
Query: 846 DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAK 904
+ +++ K L+D L++ + + A ++ ++ L ++ + KE +T+ + ++ + +
Sbjct: 793 NKEKKLKNLEDS-------LEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKR 845
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM 964
+ V D ++ +++ + D++ E K L + ++ + + K+ + + +
Sbjct: 846 KLEDQVQQDAIKVKEYNNLLNALQMDSD-EMKKILAENSRKITVLQVNEKSLIRQYTTLV 904
Query: 965 EKYTKKDKEFEAKRKELEDCKAELEE---LKQRYKEL 998
E + KE E ++ EL +AE+ E QR+KE+
Sbjct: 905 ELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEM 941
Score = 65.7 bits (153), Expect = 9e-10
Identities = 206/1088 (18%), Positives = 446/1088 (40%), Gaps = 96/1088 (8%)
Query: 46 KLQDSGTITISCKMCQSLKE-SSNEINLKLE--KLSGELFDI-KEQKSALEGKYQNLILE 101
+L DS + +S Q + E NE+ LK+E KL E+ DI + Q L + Q+ E
Sbjct: 1121 ELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR-EISDIARRQVEILNAQQQSRDKE 1179
Query: 102 TQT--RDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
++ LL Q +S E + K + N++ L +++ + +L+ L + N+
Sbjct: 1180 VESLRMQLLDYQAQSDEKSLIAKLHQ-HNVSLQL-SEATALGKLESITSKLQKMEAYNLR 1237
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIG 218
L+++ L + L + + + G + Q K + +IQ
Sbjct: 1238 LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQ----- 1292
Query: 219 YDNTLSKLNRSISDSNTSTRYNKICTLQSELDA-GREDCKELCEDFTSIKN----HLELH 273
N K+ + + +S R + TL+ EL G E+ +D + H+++
Sbjct: 1293 LQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIE 1352
Query: 274 EPNMT-MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL 332
E + + L+ +L ++ E ++SE +R ++SL E+++ +++K H +R
Sbjct: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV----QQNKFHEERQMAWD 1408
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDL-NECTSELKSVNEKL 391
+D E LD+F+ + I+N Q +E L N+ L+ + E +
Sbjct: 1409 QREVDLE---RQLDIFDRQQNEILNAAQ-KFEEATGSIPDPSLPLPNQLEIALRKIKENI 1464
Query: 392 ASLNSQLIEKENACNILRIQKERIHEISSAVTI---DIVKKENELKEILTK--ECLKLSK 446
+ +E C L +E++ E SA+ + +I+ ++ + E+ + + K
Sbjct: 1465 RII----LETRATCKSL---EEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREK 1517
Query: 447 LKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXX 506
L ++ R + + +H + I + E+ K+ RL +
Sbjct: 1518 LIAELGRK-EMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKK 1576
Query: 507 XXXXXXXXFDTLE----EAHNEVKSLHEELTKLYKSKVDENNANLNLIKI---LSEEIDA 559
LE + N+ K +L K + V N + L ++ ++E+ D+
Sbjct: 1577 HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDS 1636
Query: 560 LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERS 619
L + K ++ L E+ ++TEL +KE N L + E + +E+E
Sbjct: 1637 LSSLLVKLKKVSQDL-ERQREITELK-----VKEFENIKLQLQENHEDEVKKVKAEVEDL 1690
Query: 620 CQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ Q+ E +K+++ E L+ LALKE+ ++K
Sbjct: 1691 KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVER---LKSQLALKEK-QQKALSR 1746
Query: 680 SRLEINIK------------THEKTA-----EIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
+ LE+ + T +K A +I +R L+ Q+++ ++ ++ + L
Sbjct: 1747 ALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK 1806
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
N+ +L + + +L+ ++A N++ +K+ ++ EL+ I+ T+ +
Sbjct: 1807 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIK-RLTSGLQGKP 1865
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
EN+ G+ ++D P + + + E+ + +E Q
Sbjct: 1866 LTDNKQSLIEELQRKVKKL--ENQLEGKVEEVDLKPMKEKN--AKEELIRWEEGK-KWQA 1920
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
+++ ++ + KE + E T + L + A+ KEKL+L++++ T V++
Sbjct: 1921 KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKT------TGMTVDQV 1974
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKM 960
A+ ++++ L +D + + ++ L + +E+L + + L+ + +
Sbjct: 1975 LGIR--ALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHAL 2032
Query: 961 QKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK 1020
+K K T + + C+ E E K+ K E E + L+Q + RLK
Sbjct: 2033 EKQFSKDTYSKPSISGIESD-DHCQREQELQKENLKLSSENIELKFQ-LEQANKDLPRLK 2090
Query: 1021 -EAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
+ + E+ + L +K +++++ + + S T+ + + + + V +EN++
Sbjct: 2091 NQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQ 2150
Query: 1080 LKKMNAKL 1087
LKK + L
Sbjct: 2151 LKKASGIL 2158
Score = 57.2 bits (132), Expect = 3e-07
Identities = 198/1006 (19%), Positives = 392/1006 (38%), Gaps = 112/1006 (11%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
+ D+ E +++ K Q E Q +L+ +I+SLE E L K+I+ + +S
Sbjct: 514 MIDLTEFRNSKHLKQQQYRAENQ---ILLKEIESLEEERLDLKKKIRQMAQERGKRSATS 570
Query: 141 NELQEENDTLSNLIM-ENVTES--DNLN-KEVDDLKKNNECLTQKCIDLEKLVNESENKI 196
E+ + N+ + ++E D L+ K + + + NE L+++ I+ E+ + S I
Sbjct: 571 GLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVI 630
Query: 197 GPKNICAQCKLKENLIQS--LHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
Q KLKE + ++ L G L + D + + E
Sbjct: 631 AK----FQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAI 686
Query: 255 DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLI 314
+ K E HL+ +D+ G N E + + E ++ + S+QL
Sbjct: 687 ESKN-AEGIFDASLHLKAQ-------VDQLTGRNEELRQE----LRESRKEAINYSQQLA 734
Query: 315 NNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN---IINKYQIDLDEILEKYT 371
K DH+++ L + +D+ + + + IIN L +L++
Sbjct: 735 KANLKI--DHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELE 792
Query: 372 KVQGDLNECTSELKSVNEKLASLNSQ--------LIEKENACNILRIQKERIHEISSAVT 423
+ L L+ N K A + Q L EKE + KE ++ V
Sbjct: 793 NKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQ 852
Query: 424 IDIVK-KE-NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRT 481
D +K KE N L L + ++ K+ + R + L ++K +LI QY T
Sbjct: 853 QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITV-LQVNEK------SLIRQYT---T 902
Query: 482 DYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE-AHNEVKSLHEELTKLYKSKV 540
E+E++ LR E K +E A ++ +L KV
Sbjct: 903 LVELERQ-LRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQ---------KV 952
Query: 541 DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+N+ +L+ +++ +++ + L K + +KDN L + S + L+ EN SLK
Sbjct: 953 VDNSVSLSELELANKQYNELTA-------KYRDILQKDNMLVQRTSNLEHLECENISLKE 1005
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ I +E E +L I+Q + K+ + M +
Sbjct: 1006 QVESINKELEITKEKL----HTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITM 1061
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
L + L +++ E C ++ +++T K E +N L+ + E K+ ++ + K
Sbjct: 1062 LEMKELNERQRAEH----CQKMYEHLRTSLKQMEERN---FELETKFAELTKINLDAQ-K 1113
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE--SDIRTEQTATV 778
+ ++ + L AV D + R+ + +L + ++ +++L SDI Q +
Sbjct: 1114 VEQMLR--DELADSVSKAVSD--ADRQRILELEKNEMELKVEVSKLREISDIARRQVEIL 1169
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISV-ISDSEVSQLKERL 837
D E + + ++S+ +S++ E +
Sbjct: 1170 NAQQQSRDKEVESLRMQLL-----DYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ 897
S Q+++ R ++ DE E Y + A+ L Q + +L+ Q
Sbjct: 1225 TSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK------HLRQTIQSLRRQFSGAL 1278
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-----MKTIEELRYKKQD 952
P+ +Q KF+ + D + + + +E NK L +K +EEL +D
Sbjct: 1279 PLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNME-NKTLEMELKLKGLEELISTLKD 1337
Query: 953 LK------NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCA 1006
K N K+++ + K ++E ++E++ + E ++ L+EE
Sbjct: 1338 TKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQN 1397
Query: 1007 EYLKQREEQC-KRLKEAKIALEIVDKLSNQKV-ALEKQIESLSNTP 1050
++ ++R+ +R + + L+I D+ N+ + A +K E+ + P
Sbjct: 1398 KFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIP 1443
Score = 56.0 bits (129), Expect = 7e-07
Identities = 193/1080 (17%), Positives = 425/1080 (39%), Gaps = 94/1080 (8%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM 117
++CQ + + +I+ + E L + + +S L K LI L + +E+
Sbjct: 175 QLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEV 234
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
+N + KNL +S++ K +E N + V ++DN+ +D LKK N+
Sbjct: 235 QN---QEMRKNLEESVQEMEKMTDEY--------NRMKAIVHQTDNV---IDQLKKENDH 280
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKE-NLIQSLH----IGYDNTLSKLNRSISD 232
+ +L L+ + P + K++E LI S I Y L L + +
Sbjct: 281 YQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKN 340
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + + LQ + K L E +E + + DL +L N
Sbjct: 341 AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTC-IIEDLKNELQRNKGAS 399
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID-RYKD-----SLLAVLDAEFGTTSLD 346
T + + +I+ L+ L E+ E D R KD +L + D E G L+
Sbjct: 400 TLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLE 459
Query: 347 VFEILMDNIINKYQI---DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKEN 403
+ + N N+ +I +++ + ++ K++ +++ E +++ E++ +I+
Sbjct: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
Query: 404 ACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK 463
N +++++ + EN+ IL KE L + ++D+ + + Q
Sbjct: 520 FRNSKHLKQQQY------------RAENQ---ILLKEIESLEEERLDLKKKIRQMAQERG 564
Query: 464 KITILFDALITQYELSRTDYEIEKEKL---RLETGTAKAVXXXXXXXXXXXXXXFDT--- 517
K + +T +L+ T+ + +++ +L+ + K + +
Sbjct: 565 KRSATSG--LTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERD 622
Query: 518 LEEAHNEVKSLHEELTKLYKS--KVDENNAN-LNLIKILSEEIDAL---KIAIAKNEEKM 571
LE + + +L +L + +++E L IK + ++ D I + E++
Sbjct: 623 LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL 682
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE-KETQASELERSCQVIKQNGFEL 630
++ E N ++++ LK + + L N+ + +E +E++ + S Q+ K N ++
Sbjct: 683 VNAIESKNAEGIFDASLH-LKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKAN-LKI 740
Query: 631 DKMKADI-LMXXXXXXXXXXXXXXXXD-----EAKSLLEQN---LALKEQCEEKTRDCSR 681
D ++ + L+ D A + QN + L ++ E K +
Sbjct: 741 DHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKN 800
Query: 682 LEINIKTHE-KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVK 740
LE +++ + K A I+++ + ++ + E + E +T E + +++D A+K
Sbjct: 801 LEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQD---AIK 857
Query: 741 DLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT 800
++ +N L D ++ +AE I Q
Sbjct: 858 -VKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEK 916
Query: 801 FGDENRDLGEN--PKLDDSPK-RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDE 857
+E + K+ + + +++ + + ++ + +S EL+ ++Y EL +
Sbjct: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS-ELELANKQYNELTAK 975
Query: 858 CETCAE---YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE 914
+ L +R L+ E +SL++QV ++ +++ + + + A +
Sbjct: 976 YRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEI---TKEKLHTIEQAWEQET 1032
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
N S+ D+ + K I L K+ + + QK E K+
Sbjct: 1033 KLGNESSM--DKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM 1090
Query: 975 EAKRKELEDCKAELEELK---QRYKEL--DEECETCAEYLKQREEQ-CKRLKEAKIALEI 1028
E + ELE AEL ++ Q+ +++ DE ++ ++ + + Q L++ ++ L++
Sbjct: 1091 EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150
Query: 1029 -VDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
V KL +Q+E L+ S + ++ Q +D KL + N L
Sbjct: 1151 EVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSL 1210
Score = 56.0 bits (129), Expect = 7e-07
Identities = 215/1102 (19%), Positives = 436/1102 (39%), Gaps = 120/1102 (10%)
Query: 59 MCQSLKESSNEINLKLEKLS--GELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLE 116
+ Q K S I L+ +KL E+ + +++ +E K + L+ + + L+S +K +
Sbjct: 1280 LAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTK 1339
Query: 117 MENLTKDKEIKNLTDSLKTKSKKIN-EL---QEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ +K + L+ + K+N EL +EE L+N+I E +L +E+
Sbjct: 1340 GAQKVINWHMK--IEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQN 1397
Query: 173 KNNE----CLTQKCIDLEK---LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
K +E Q+ +DLE+ + + +N+I N + + I + N L
Sbjct: 1398 KFHEERQMAWDQREVDLERQLDIFDRQQNEI--LNAAQKFEEATGSIPDPSLPLPNQLEI 1455
Query: 226 LNRSISDS-NTSTRYNKICTLQSELDAGREDCKELCEDFT----SIKNHLELHEPNMTMD 280
R I ++ C E +E L E + N L L P T +
Sbjct: 1456 ALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLP-ATAE 1514
Query: 281 LDEKLGE--NNEFETKAVKVMSEIKRNLNSLSEQLINNES--KKSKDHIDRYKDSLLAVL 336
++ + E E E K+ + + + ++ +L E KK + +++ ++ ++
Sbjct: 1515 REKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIV 1574
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE---KLAS 393
E + + ++ ++ D L K+ + DL + + N+ +LA
Sbjct: 1575 KKH---------EEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 1625
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
+ + E++++ + L ++ +++ + D+ +++ E+ E+ KE +K+ +
Sbjct: 1626 MEQTVAEQDDSLSSLLVKLKKVSQ-------DL-ERQREITELKVKE---FENIKLQLQE 1674
Query: 454 DLDQDLPAHKK----ITILFDALITQYELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXX 508
+ + ++ K + L D + + +++ + +KE R T T + +
Sbjct: 1675 NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 1734
Query: 509 XXXXXXFDTLEEAHNEVKS-LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN 567
L A E+++ + + S + A+LN+ +I+ LK +
Sbjct: 1735 ALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDL 1794
Query: 568 EEKMLSLSE----KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
E +L L E N+ L +N L E + + I REKE E+++
Sbjct: 1795 NENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKE----EIDQ----- 1845
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
E D++K I D +SL+E+ L K + E + E
Sbjct: 1846 -----ENDELKRQI-----KRLTSGLQGKPLTDNKQSLIEE-LQRKVKKLENQLEGKVEE 1894
Query: 684 INIKT-HEKTAE---IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
+++K EK A+ I+ + Q +I+ EKE ++ LT + LK + A
Sbjct: 1895 VDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKAD 1954
Query: 740 KDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
K+ + + + D V G I LES+ E+
Sbjct: 1955 KEKLTLQRKLKTTGMTVDQVLG-IRALESEKELEELKKRNLDLENDILYMRAHQALPRDS 2013
Query: 800 TFGD---ENRDLGENPKL-------DDSPKRSISVISDSEVSQLKERL----LSCQQELD 845
D +NR L E D K SIS I + Q ++ L L E
Sbjct: 2014 VVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENI 2073
Query: 846 DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
+LK + ++ + + +++ E C LKKEK +++++ +++ R+ + +
Sbjct: 2074 ELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL--- 2130
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
E L VV+++ + E K + T E++ +Q+ + +++K
Sbjct: 2131 --------EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
+ +E+K K E AE E L+ KEL +E + AE L+ + + L E K+
Sbjct: 2183 HLGHQLSMHYESKTKGTEKIIAENERLR---KELKKETD-AAEKLRIAKNNLEILNE-KM 2237
Query: 1025 ALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI-TDVMKENQKLKKM 1083
+++ + + A E + L + V T + +++ TD+ K+NQ + +
Sbjct: 2238 TVQLEETGKRLQFA-ESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDL 2296
Query: 1084 NAKLITICKKRGKTGANRENED 1105
+L+ +R + N+ NED
Sbjct: 2297 K-QLVKEATER-EQKVNKYNED 2316
Score = 54.8 bits (126), Expect = 2e-06
Identities = 188/1010 (18%), Positives = 398/1010 (39%), Gaps = 98/1010 (9%)
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSK-KINELQEENDTLSNLI 154
+N LET+ +L + + ++E + +D+ +++ ++ + +I EL++ L +
Sbjct: 1093 RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEV 1152
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
+ SD ++V+ L + ++ L + + + + K++ A KL ++ + S
Sbjct: 1153 SKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIA--KLHQHNV-S 1209
Query: 215 LHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDA-----------GREDCKELCEDF 263
L + L KL S YN L+ +LD GR K L +
Sbjct: 1210 LQLSEATALGKLESITSKLQKMEAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTI 1267
Query: 264 TSIKNHLELHEPNMTMDLDEKLGENN-EFETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
S++ P + EK + + + +K+M E+K NS E N E+K +
Sbjct: 1268 QSLRRQFSGALP---LAQQEKFSKTMIQLQNDKLKIMQEMK---NSQQEHR-NMENKTLE 1320
Query: 323 DHID-RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + + L++ L G + + + ++ + ++ L+ L K + LN
Sbjct: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEEL-RLQELKLNRELVKDKEEIKYLNNII 1379
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
SE + ++SL ++++ +N + R E+ +DI ++ EIL
Sbjct: 1380 SEYERT---ISSLEEEIVQ-QNKFHEERQMAWDQREVDLERQLDIFDRQQN--EILNA-A 1432
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLET-GTAKAV 500
K + IP D LP L Q E++ + E ++ LET T K++
Sbjct: 1433 QKFEEATGSIP---DPSLP-----------LPNQLEIALRKIK-ENIRIILETRATCKSL 1477
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDAL 560
+ + L L ++ ++ A L ++ + L
Sbjct: 1478 EEKLKEKESALRLAEQNILSRDKVINELRLRLPAT--AEREKLIAELGRKEMEPKSHHTL 1535
Query: 561 KIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLND----VITREKETQASEL 616
KIA L++K+ L + + +EE + ++ ++ E QA
Sbjct: 1536 KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQA--- 1592
Query: 617 ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT 676
+ S KQ ++L K + ++ SL + LK+ ++
Sbjct: 1593 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE 1652
Query: 677 RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD 736
R E+ +K E +N ++LQ Q +D++ K ++ +L + +++
Sbjct: 1653 RQREITELKVK------EFEN---IKLQLQENHEDEVKKVK-AEVEDLKYLLDQSQKESQ 1702
Query: 737 AAVKDLESSREAVNQL--TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+L++ +EA ++ TT ++LVE ++L ++ +Q +
Sbjct: 1703 CLKSELQAQKEANSRAPTTTMRNLVERLKSQLA--LKEKQQKALSRALLELRAEMTAAAE 1760
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
+ L ++ D R + ++V L E LL ++ L K R L
Sbjct: 1761 ERIISATSQKEAHLNVQ-QIVDRHTRELK----TQVEDLNENLLKLKEALKTSKNRENSL 1815
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE 914
D LQ++ + ++ +EK ++Q+ LK QI+ + D
Sbjct: 1816 TDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTD------- 1868
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
N S++ + ++E +L +EE+ K KN ++ + E+ K +
Sbjct: 1869 ---NKQSLIEELQRKVKKLE--NQLEGKVEEVDLKPMKEKNAKEELIR-WEEGKKWQAKI 1922
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
E R +L++ + E+ L K+L+ + A+ K++ ++LK + ++ V L
Sbjct: 1923 EGIRNKLKEKEGEVFTLT---KQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQV--LGI 1977
Query: 1035 QKVALEKQIESLS--NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ + EK++E L N + N +Y+ A+ ++ + D+ +N+ L++
Sbjct: 1978 RALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE 2027
Score = 50.0 bits (114), Expect = 5e-05
Identities = 158/788 (20%), Positives = 319/788 (40%), Gaps = 97/788 (12%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGE-LF 82
+++L K N T + + + + K ++L + E+ ++ + E +
Sbjct: 1705 KSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERII 1764
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
QK A Q I++ TR+L +Q++ L ENL K KE +LKT + N
Sbjct: 1765 SATSQKEAHLNVQQ--IVDRHTREL-KTQVEDLN-ENLLKLKE------ALKTSKNRENS 1814
Query: 143 LQEENDTLSNLIMEN-------VTESDNLNKEVDDLKKNNECLTQ----KCI--DLEKLV 189
L + + L+N + + + E + +++E D+LK+ + LT K + + + L+
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
Query: 190 NESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY----NKICTL 245
E + K+ K + Q + K + + N +L R + NK+
Sbjct: 1875 EELQRKV--KKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK 1932
Query: 246 QSELDAGREDCKELCEDFTSI-KNHLELHEPNMT--MDLDEKLG---ENNEFETKAVKVM 299
+ E+ + L + F K L L T M +D+ LG +E E + +K
Sbjct: 1933 EGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKR 1992
Query: 300 SEIKRN--LNSLSEQLINNESKKSKDHI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ N L + Q + +S H+ +RY L L+ +F + I
Sbjct: 1993 NLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESD 2052
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK---- 412
+ Q + E+ ++ K+ + E +L+ N+ L L +Q+ + + C L+ +K
Sbjct: 2053 DHCQRE-QELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111
Query: 413 -------------ERIHEISSAV-----TIDIVKKENE-LKE---ILTKECL-KLSKLKI 449
+ I E+ + ++ V++ENE LK+ ILT E + + +
Sbjct: 2112 RKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
Query: 450 DIPRDLDQDLPAH--KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXX 507
+ +L++ L AH ++++ +++ E + E +++L+ ET A+ +
Sbjct: 2172 KLKAELEK-LKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL 2230
Query: 508 XXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN 567
LEE ++ +L + ++ ++ + ++ ++ L+ IAK
Sbjct: 2231 EILNEKMTVQLEETGKRLQFAESRGPQL-EGADSKSWKSIVVTRMYETKLKELETDIAKK 2289
Query: 568 EEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNG 627
+ + L + + TE +N E+ + + ET+ L+R QV++
Sbjct: 2290 NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG-LKRELQVLRLAN 2348
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
+LDK KA+++ ++ +S E + +Q +EK +D LE +K
Sbjct: 2349 HQLDKEKAELI------------HQIEANKDQSGAESTIPDADQLKEKIKD---LETQLK 2393
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+ + I +L+K+++ D F E + E LK +Y VK E
Sbjct: 2394 MSDLEKQHLKEEIKKLKKELENFDPSFFE----------EIEDLKYNYKEEVKKNILLEE 2443
Query: 748 AVNQLTTQ 755
V +L+ Q
Sbjct: 2444 KVKKLSEQ 2451
Score = 47.2 bits (107), Expect = 3e-04
Identities = 117/611 (19%), Positives = 242/611 (39%), Gaps = 45/611 (7%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANL-NLIKILSEEIDALKIAIAKNEEKMLS--L 574
+E A EV+ EE K +++++ L N +++ + +NE L L
Sbjct: 66 VELALEEVEKAGEEQAK-FENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
Query: 575 SEKDNKLTELVSTINGLKEENNSL-------KSLNDVITREKETQASELERSCQVIKQNG 627
+KD +L ++ + K+ N L ++ N + RE + + E+ CQ I
Sbjct: 125 EQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQ 184
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXX-------DEAKSLLEQNLALKEQCEEKTRDCS 680
++D K +L DE ++L E N ++ Q +E ++
Sbjct: 185 KQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN-- 242
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE---TKLNELTNKYEALKRDYDA 737
LE +++ EK + NRM + + D+L E + ++ ELT+ ++ + D
Sbjct: 243 -LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDP 301
Query: 738 AVKDLESSREAVNQLTTQKD--LVEGR--IAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
+ + + E + + KD ++E + + L ++ Q
Sbjct: 302 IMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERD 361
Query: 794 XXXXXXTFGDEN--RDLGENPKLDDSPKRSISVISDSEVSQLKERL-LSCQQELDDLKER 850
T E +++ +N + + K + + S L ++ + Q LD LKE+
Sbjct: 362 SQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQ--RNKGASTLSQQTHMKIQSTLDILKEK 419
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
KE + E +E+D++ K E V L++ + + + Q K D +
Sbjct: 420 TKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREI 479
Query: 911 N-TDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYT 968
++ L + D + + + + L KT+ +L + ++ K+ + +A +
Sbjct: 480 EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLT-EFRNSKHLKQQQYRAENQIL 538
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE--EQCKRLKEAKIAL 1026
KE E+ +E D K ++ ++ Q + E L E Q R+ E K+ L
Sbjct: 539 L--KEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDL 596
Query: 1027 EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVMKENQKLKKMNA 1085
L N A K E LS + + + I + Q ++ ++++EN++L++
Sbjct: 597 L---SLKNMSEAQSKN-EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMK 652
Query: 1086 KLITICKKRGK 1096
+++ K+ K
Sbjct: 653 EILQAIKEMQK 663
Score = 46.8 bits (106), Expect = 4e-04
Identities = 178/894 (19%), Positives = 353/894 (39%), Gaps = 97/894 (10%)
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE--KLVNESENKIGPKNIC 202
E++D+LS+L+++ L K DL++ E K + E KL + ++ K +
Sbjct: 1632 EQDDSLSSLLVK-------LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVK 1684
Query: 203 AQCK-LKENLIQSLHIGY--DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKEL 259
A+ + LK L QS + L + S + T+T N + L+S+L + K L
Sbjct: 1685 AEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKAL 1744
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
LEL MT +E++ + S+ + +LN +Q+++ ++
Sbjct: 1745 SRAL------LELRA-EMTAAAEERI----------ISATSQKEAHLNV--QQIVDRHTR 1785
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K ++ ++LL + +A TS + L DN+ N +L + + Y K+ + E
Sbjct: 1786 ELKTQVEDLNENLLKLKEAL--KTSKNRENSLTDNL-NDLNNELQKKQKAYNKILREKEE 1842
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
E + ++ L S L K N ++ I E+ V K EN+L+ + +
Sbjct: 1843 IDQENDELKRQIKRLTSGLQGKPLTDN----KQSLIEELQRKVK----KLENQLEGKVEE 1894
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD-YEIEKEKLRLETGTAK 498
LK K K + +L + KK + + + + + + + K+ L+ AK
Sbjct: 1895 VDLKPMKEK-NAKEELIR-WEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAK 1952
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI--KILSEE 556
A + +EL +L K +D N L + + L +
Sbjct: 1953 ADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRD 2012
Query: 557 --IDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
++ L + +EK+ +L ++ +K T +I+G++ + D RE+E Q
Sbjct: 2013 SVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESD--------DHCQREQELQKE 2064
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
L+ S + I+ F+L++ D+ E L++ A ++
Sbjct: 2065 NLKLSSENIELK-FQLEQANKDL--------PRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK----LFIEKETKLNELTNKYEA 730
R R I EKT + +++ ++Q++ ++ K L EK + + K +A
Sbjct: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKA 2175
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
A + S T+K + E L +++ E A
Sbjct: 2176 ELEKLKAHLGHQLSMHYESKTKGTEKIIAENE--RLRKELKKETDAAEKLRIAKNNLEIL 2233
Query: 791 XXXXXXXXXTFGDENRDL-GENPKLDDSPKRS-----ISVISDSEVSQLKERLLSCQQEL 844
G + P+L+ + +S ++ + ++++ +L+ + Q +
Sbjct: 2234 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSI 2293
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKK--EKLSLEQQVSNLKEQIR-TQQPVER 901
DLK+ KE + + +Y ++ ++Q LK E EQ + + +R +++
Sbjct: 2294 TDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDK 2353
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
+ + ++D + S + D D EK K L ++ +KQ LK + K++
Sbjct: 2354 EKAELIHQIEANKDQSGAESTIPDA---DQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 2410
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
K +E + D F E+E+LK YKE ++ E +K+ EQ
Sbjct: 2411 KELENF---DPSFFE----------EIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451
Score = 40.7 bits (91), Expect = 0.028
Identities = 187/1064 (17%), Positives = 404/1064 (37%), Gaps = 69/1064 (6%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEG---KYQNLILETQTRDLLMSQIKSLEMENLTKDKE 125
E+ L+ KL+ EL KE+ L +Y+ I + + ++ Q K E + D+
Sbjct: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTI--SSLEEEIVQQNKFHEERQMAWDQR 1410
Query: 126 IKNLTDSLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQK 181
+L L ++ NE+ Q+ + ++ ++ + L + +K+N + +
Sbjct: 1411 EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470
Query: 182 ---CIDLEKLVNESEN--KIGPKNICAQCKLKENLIQSLHIGYDNT--LSKLNRSISDSN 234
C LE+ + E E+ ++ +NI ++ K+ L L + +++L R +
Sbjct: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1530
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFET 293
+ + + A +E+ + + + + + +E L ++ E
Sbjct: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
+A +++ K+ L +Q + + H R + V + + +SL V +
Sbjct: 1591 QADSSLNKFKQTAWDLMKQ--SPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVS 1648
Query: 354 NIINKYQIDLDEI-LEKYTKVQGDLNEC-TSELKSVNEKLASLNSQL--IEKENAC--NI 407
+ + Q ++ E+ ++++ ++ L E E+K V ++ L L +KE+ C +
Sbjct: 1649 QDLER-QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSE 1707
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI-- 465
L+ QKE + ++V++ + K+ LS+ +++ ++ A ++I
Sbjct: 1708 LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTA--AAEERIIS 1765
Query: 466 -TILFDA-LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
T +A L Q + R E++ + L K + D L + +N
Sbjct: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLK-LKEALKTSKNRENSLTDNLNDLNN 1824
Query: 524 EVKSLHEELTKLYKSK--VDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
E++ + K+ + K +D+ N L IK L+ + + + K + E K
Sbjct: 1825 ELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLT----DNKQSLIEELQRK 1880
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
+ +L + + G K E LK + + +E+ + E ++ I+ +L + + ++
Sbjct: 1881 VKKLENQLEG-KVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF-T 1938
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE---KTAEIQN 697
D+ K L++ L ++ LE + E + +++N
Sbjct: 1939 LTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEN 1998
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDA------AVKDLESSREAVNQ 751
++ Q D + + + L K AL++ + ++ +ES +
Sbjct: 1999 DILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQRE 2058
Query: 752 LTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
QK+ ++ +E + EQ A + R LG
Sbjct: 2059 QELQKENLKLSSENIELKFQLEQ-ANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV 2117
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
S K + + + +K+ + Q+E + LK+ L E A QE ++
Sbjct: 2118 RGSGRSGKTIPEL--EKTIGLMKKVVEKVQRENEQLKKASGILTSE--KMANIEQENEKL 2173
Query: 872 CARLKKEKLSLEQQVS-NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
A L+K K L Q+S + + + + + + + + + + D A + + +
Sbjct: 2174 KAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEI- 2232
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKK---DKEFEAKRKELEDCKAE 987
N+++ +EE + Q ++ +++ A K K + +E K KELE A+
Sbjct: 2233 ----LNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAK 2288
Query: 988 ----LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+ +LKQ KE E + +Y + E+Q K LK E L + L
Sbjct: 2289 KNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLAN 2348
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
L A I D + +K+K + +L
Sbjct: 2349 HQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392
>BX537964-1|CAD97928.1| 898|Homo sapiens hypothetical protein
protein.
Length = 898
Score = 67.3 bits (157), Expect = 3e-10
Identities = 109/556 (19%), Positives = 237/556 (42%), Gaps = 43/556 (7%)
Query: 531 ELTKLYKSKVDENNANLNLIK-----ILSEEIDALKIAIAKNE-EKMLSLSEK--DNKLT 582
+ TK + SK+ +A+ +L++ +LS E ++ N+ E L L EK +K
Sbjct: 144 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYL 203
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ I L +EN + L I EK+ EL++ + KQ+ + ++++ I
Sbjct: 204 QQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK 263
Query: 643 XXXXXXXXXXXXXDEAKSLLEQ---NLALK-----EQCEEKTRDCSRLEINIKTHEKTAE 694
AK+ ++Q +A + ++CEE ++ + + EK +
Sbjct: 264 EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL 323
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAAVKDLESSRE 747
+ L+K++++ +K + K+ +L+ + YE + + +++++ +E
Sbjct: 324 DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKE 383
Query: 748 AVNQLTTQKDLVEGRI-AELESDIRTE---QTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+N + + ++ AE++S T+ + T T+
Sbjct: 384 DINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY-Q 442
Query: 804 ENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECET- 860
E+ ++ N +LD + + + E S E + +EL+DLK +KE DE T
Sbjct: 443 ESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTL 501
Query: 861 -----CAEYLQERDEQCARLKKEKLSLEQ-QVSNLKEQIRTQQPVERQAKFADVAV-NTD 913
C E + R E KE ++ ++ ++ NL ++++T ++ Q + + N
Sbjct: 502 RTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLK 561
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ +L+S++ D + + ++ L+ E L K L++ +Q +K + +
Sbjct: 562 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSES 621
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
+ +++ ++++ LE + +EL EE +T L R+ + K L E+ D+
Sbjct: 622 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQ--VEELKDE 679
Query: 1032 LSNQKVALEKQIESLS 1047
L Q+ I+ L+
Sbjct: 680 LVTQRRKHASSIKDLT 695
Score = 56.4 bits (130), Expect = 5e-07
Identities = 106/632 (16%), Positives = 254/632 (40%), Gaps = 58/632 (9%)
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI---SS 420
+ ++ KY + + + + E +++ +KL N +L + N L +K R+H++
Sbjct: 309 EAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKE 368
Query: 421 AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI----TILFDALITQY 476
T ++++ ++LKE + +K+ + + ++D K+ T L A
Sbjct: 369 GETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAD 428
Query: 477 ELSRTDYEI-----EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
++ + ++ E E+++ AK + D LE H ++K L E+
Sbjct: 429 QIRKNCQDMIKTYQESEEIKSNELDAK-LRVTKGELEKQMQEKSDQLEMHHAKIKEL-ED 486
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + +K +DE +K L +E + ++K +E + + L + V T + L
Sbjct: 487 LKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQL 546
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+E+ K + + E E+ S + + I+ + K ++++L+
Sbjct: 547 QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS----RKRESELLLFTERLTSKNAQL 602
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH-EKTAEIQNRMIMRLQKQIQED 710
+ +S ++ + Q + + + IN+++ K E++ + LQ ++
Sbjct: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAEL--- 659
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI 770
++T++ L+ + E LK D V ++ LT Q ++ ++ES
Sbjct: 660 ----ACRQTEVKALSTQVEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGS 712
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
++ +++ EN G + +D+ P+ +
Sbjct: 713 YDKEVSSMGSRSSSSGSLNARSSAEDR----SPEN--TGSSVAVDNFPQ--------VDK 758
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE--QCARLKKEKLSLEQQVSN 888
+ L ER++ Q+ E+ + ++D + E ++++ + Q L++E +L + S+
Sbjct: 759 AMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASD 818
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++ R A + + D + ++ + +E N++L+ +E+
Sbjct: 819 FNKVHLSR----RGGIMASLYTSHPAD---------NGLTLELSLEINRKLLAVLEDTLL 865
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
K LK + + +E+ K E E + K+
Sbjct: 866 KNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
Score = 52.4 bits (120), Expect = 9e-06
Identities = 144/747 (19%), Positives = 301/747 (40%), Gaps = 68/747 (9%)
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
K + D + I +L +EN L ++ +E DNL +E LKK E Q ++
Sbjct: 196 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQHMNTIK 252
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+L E++I N + K + + + + N + +L++ + + + NK C
Sbjct: 253 QL----ESRIEELN--KEVKASRDQLIAQDVTAKNAVQQLHKEM--AQRMEQANKKCE-- 302
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFE--TKAVKVMSEIK 303
+A +E + + K L+L + T L++KL + N E E T +K +S+ K
Sbjct: 303 ---EARQEKEAMVMKYVRGEKESLDLRKEKET--LEKKLRDANKELEKNTNKIKQLSQEK 357
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLA-VLDAEFGTTSLDVFEILMDNIINKYQID 362
L+ L E E+ + ID+ K+ + + V+ ++ L + MD+ ++
Sbjct: 358 GRLHQLYETK-EGETTRLIREIDKLKEDINSHVIKVKWAQNKL---KAEMDS----HKET 409
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSA 421
D++ E TK+ E K+ + + + K N + LR+ K + +
Sbjct: 410 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK---- 465
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD-ALITQYELSR 480
+ +K ++L E+ + +L LK +D+ K+ L D L T+ ELS+
Sbjct: 466 ---QMQEKSDQL-EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 481 TDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
I ++K ++ K +E EV+SL+ + L K +
Sbjct: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK--QEIENLKEEVESLNSLINDLQKD-I 578
Query: 541 DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN-KLTELVSTINGLKEENNSLK 599
+ + + + + +E + + + + S +K + ++L S +K+ N +L+
Sbjct: 579 EGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE 638
Query: 600 S--LNDVITREKETQASELERSCQ--VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
S L + R++E Q + E +C+ +K +++++K +++
Sbjct: 639 SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQL 698
Query: 656 DEAKSLLEQ---NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR-MIMRLQKQIQEDD 711
+A+ L+Q KE +R S +N ++ + +N + + Q D
Sbjct: 699 QQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDK 758
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ IE+ +L K A K + +E + + QL + + + ++S I
Sbjct: 759 AMLIERIVRL----QKAHARKNE------KIEFMEDHIKQLVEE---IRKKTKIIQSYIL 805
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-DSPKRSISVISDSEV 830
E++ T+ + D G +L + ++ ++V+ D+ +
Sbjct: 806 REESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLLAVLEDTLL 865
Query: 831 SQ--LKERLLSCQQELDDLKERYKELD 855
LKE L + E++ L + EL+
Sbjct: 866 KNITLKENLQTLGTEIERLIKHQHELE 892
Score = 49.6 bits (113), Expect = 6e-05
Identities = 95/504 (18%), Positives = 207/504 (41%), Gaps = 38/504 (7%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS-EK 577
+E ++ S + L + K + + ++N IK L I+ L + + +++++
Sbjct: 220 QELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTA 279
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N + +L + E+ N K + +EKE + R ++ +L K K +
Sbjct: 280 KNAVQQLHKEMAQRMEQAN--KKCEEA-RQEKEAMVMKYVRG----EKESLDLRKEKETL 332
Query: 638 ---LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE-QCEEKTRDCSRLEINIKTHE-KT 692
L + K L Q KE + R+ +L+ +I +H K
Sbjct: 333 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 392
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV-NQ 751
QN++ + + DKL E TKL + + + ++++ +K + S E N+
Sbjct: 393 KWAQNKLKAEMDSHKETKDKLK-ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 451
Query: 752 LTTQKDLVEGRIAEL---ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDE 804
L + + +G + + +SD A + T DE
Sbjct: 452 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE 511
Query: 805 NR----DLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDEC 858
+L + ++ + K I + D QL+E+L +QE+++LKE + L+
Sbjct: 512 RLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLN--- 568
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ LQ+ E + + E L +++++ Q++++ Q++F V+ + + +
Sbjct: 569 -SLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESN-SLQSQFDKVSCSESQLQSQ 626
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK--KDKEFEA 976
+ ++ ++ + K + L K EE++ + +L T++ KA+ + KD+
Sbjct: 627 CEQMKQTNINLESRLLKEEELRK--EEVQTLQAELACRQTEV-KALSTQVEELKDELVTQ 683
Query: 977 KRKELEDCKAELEELKQRYKELDE 1000
+RK K ++L+Q ++LD+
Sbjct: 684 RRKHASSIKDLTKQLQQARRKLDQ 707
Score = 47.2 bits (107), Expect = 3e-04
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 19/229 (8%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ + D ++Q + QQ ++ +R ++ + +CE + + + R +KE
Sbjct: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
L L ++ L++++R + K + ++ LH + Y+ + + RL
Sbjct: 323 LDLRKEKETLEKKLRDAN--KELEKNTNKIKQLSQEKGRLHQL------YETKEGETTRL 374
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
++ I++L K+D+ + V K++ A K E ++ ++ + K +L Q +E D
Sbjct: 375 IREIDKL---KEDINSHVIKVKWAQNKL---KAEMDSHKETKDKLKETTTKLTQAKEEAD 428
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + C + +K +E +E K + E+ KL K LEKQ++ S+
Sbjct: 429 QIRKNCQDMIKTYQES----EEIK-SNELDAKLRVTKGELEKQMQEKSD 472
Score = 46.4 bits (105), Expect = 6e-04
Identities = 66/335 (19%), Positives = 148/335 (44%), Gaps = 27/335 (8%)
Query: 86 EQKSALEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSL-KTKSKKINEL 143
++++ E ++ N I + ++R + L ++K+ + + +D KN L K ++++ +
Sbjct: 238 KKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQA 297
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
++ + V + KE DL+K E L +K D K + ++ NKI K +
Sbjct: 298 NKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKI--KQLSQ 355
Query: 204 QCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC--TLQSELDAGRE---DCKE 258
+ L ++ + ++++ D N+ K L++E+D+ +E KE
Sbjct: 356 EKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE 415
Query: 259 LCEDFTSIKNHLELHEPN-----MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
T K + N T E++ ++NE + K E+++ + S+QL
Sbjct: 416 TTTKLTQAKEEADQIRKNCQDMIKTYQESEEI-KSNELDAKLRVTKGELEKQMQEKSDQL 474
Query: 314 INNESK-KSKDHIDR-YKDSLLAVLDAEFGTTSLDVFEILMDN-------IINKYQIDLD 364
+ +K K + + R +K+ + + L+ + ++ IIN+ + ++
Sbjct: 475 EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQ 534
Query: 365 EILEKY---TKVQGDLNECTSELKSVNEKLASLNS 396
+L+K ++Q L E++++ E++ SLNS
Sbjct: 535 NLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS 569
Score = 41.9 bits (94), Expect = 0.012
Identities = 71/347 (20%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME---NLT 121
+S E KL++ + +L KE+ + Q++I Q + +IKS E++ +T
Sbjct: 404 DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESE----EIKSNELDAKLRVT 459
Query: 122 K---DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
K +K+++ +D L+ KI EL++ L E + E L +V L+
Sbjct: 460 KGELEKQMQEKSDQLEMHHAKIKELED----LKRTFKEGMDELRTLRTKVKCLEDERLRT 515
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ ++++N + +I +N+ + K + L + L G + L + N+
Sbjct: 516 EDELSKYKEIINRQKAEI--QNLLDKVKTADQLQEQLQRGKQE-IENLKEEVESLNSL-- 570
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
I LQ +++ R+ EL L +T + E+N +++ KV
Sbjct: 571 ---INDLQKDIEGSRKRESELL-----------LFTERLTSKNAQLQSESNSLQSQFDKV 616
Query: 299 M---SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
S+++ + + IN ES+ K+ R ++ + L AE +V +
Sbjct: 617 SCSESQLQSQCEQMKQTNINLESRLLKEEELRKEE--VQTLQAELACRQTEVKALSTQ-- 672
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + + DE++ + K + + T +L+ KL + S +KE
Sbjct: 673 VEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 716
Score = 41.5 bits (93), Expect = 0.016
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 48/286 (16%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL-QDSGTITISCK-MCQSLKES----SNEINLKLEKLSG 79
++D K D + ET + + +++ I +C+ M ++ +ES SNE++ KL G
Sbjct: 402 EMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKG 461
Query: 80 ELFDIKEQKS-ALEGKYQNLI-LETQTRDL---------LMSQIKSLEMENL-TKDK--- 124
EL ++KS LE + + LE R L +++K LE E L T+D+
Sbjct: 462 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 125 ----------EIKNLTDSLKTK----------SKKINELQEENDTLSNLIMENVTESDNL 164
EI+NL D +KT ++I L+EE ++L++LI + + +
Sbjct: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS 581
Query: 165 NKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLS 224
K +L E LT K L+ N +++ K C++ +L+ Q N S
Sbjct: 582 RKRESELLLFTERLTSKNAQLQSESNSLQSQF-DKVSCSESQLQSQCEQMKQTNI-NLES 639
Query: 225 KLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+L + R ++ TLQ+EL + + K L +K+ L
Sbjct: 640 RLLK-----EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL 680
Score = 35.9 bits (79), Expect = 0.80
Identities = 86/423 (20%), Positives = 173/423 (40%), Gaps = 45/423 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ--NLILETQTRDLL-MSQIKS 114
K C+ ++ + +K + E D++++K LE K + N LE T + +SQ K
Sbjct: 299 KKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKG 358
Query: 115 -LEMENLTKD-------KEIKNLTDSLKTKSKKI----NELQEENDT---LSNLIMENVT 159
L TK+ +EI L + + + K+ N+L+ E D+ + + E T
Sbjct: 359 RLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTT 418
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE----NKIGPKNICAQCKLKENLIQ-- 213
+ +E D ++KN C D+ K ESE N++ K + +L++ + +
Sbjct: 419 KLTQAKEEADQIRKN-------CQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKS 471
Query: 214 ---SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+H L L R+ + R + T L+ R ++ + I N
Sbjct: 472 DQLEMHHAKIKELEDLKRTFKEGMDELR--TLRTKVKCLEDERLRTEDELSKYKEIINRQ 529
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ N+ +D + + E + + + +K + SL+ LIN+ K + R +
Sbjct: 530 KAEIQNL-LDKVKTADQLQEQLQRGKQEIENLKEEVESLN-SLINDLQKDIEGSRKRESE 587
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV-QGDLNECTSELKSVNE 389
LL L + + +K ++ + ++ Q ++N + LK E
Sbjct: 588 LLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK--EE 645
Query: 390 KLASLNSQLIEKENACNILRIQ--KERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
+L Q ++ E AC ++ ++ E+ + K + +K+ LTK+ L+ ++
Sbjct: 646 ELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKD-LTKQ-LQQARR 703
Query: 448 KID 450
K+D
Sbjct: 704 KLD 706
>BC105632-1|AAI05633.1| 898|Homo sapiens chromosome 10 open reading
frame 118 protein.
Length = 898
Score = 67.3 bits (157), Expect = 3e-10
Identities = 109/556 (19%), Positives = 237/556 (42%), Gaps = 43/556 (7%)
Query: 531 ELTKLYKSKVDENNANLNLIK-----ILSEEIDALKIAIAKNE-EKMLSLSEK--DNKLT 582
+ TK + SK+ +A+ +L++ +LS E ++ N+ E L L EK +K
Sbjct: 144 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYL 203
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ I L +EN + L I EK+ EL++ + KQ+ + ++++ I
Sbjct: 204 QQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK 263
Query: 643 XXXXXXXXXXXXXDEAKSLLEQ---NLALK-----EQCEEKTRDCSRLEINIKTHEKTAE 694
AK+ ++Q +A + ++CEE ++ + + EK +
Sbjct: 264 EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL 323
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAAVKDLESSRE 747
+ L+K++++ +K + K+ +L+ + YE + + +++++ +E
Sbjct: 324 DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKE 383
Query: 748 AVNQLTTQKDLVEGRI-AELESDIRTE---QTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+N + + ++ AE++S T+ + T T+
Sbjct: 384 DINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY-Q 442
Query: 804 ENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECET- 860
E+ ++ N +LD + + + E S E + +EL+DLK +KE DE T
Sbjct: 443 ESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTL 501
Query: 861 -----CAEYLQERDEQCARLKKEKLSLEQ-QVSNLKEQIRTQQPVERQAKFADVAV-NTD 913
C E + R E KE ++ ++ ++ NL ++++T ++ Q + + N
Sbjct: 502 RTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLK 561
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ +L+S++ D + + ++ L+ E L K L++ +Q +K + +
Sbjct: 562 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSES 621
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
+ +++ ++++ LE + +EL EE +T L R+ + K L E+ D+
Sbjct: 622 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQ--VEELKDE 679
Query: 1032 LSNQKVALEKQIESLS 1047
L Q+ I+ L+
Sbjct: 680 LVTQRRKHASSIKDLT 695
Score = 55.6 bits (128), Expect = 9e-07
Identities = 106/632 (16%), Positives = 253/632 (40%), Gaps = 58/632 (9%)
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI---SS 420
+ ++ KY + + + + E +++ +KL N +L + N L +K R+H++
Sbjct: 309 EAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKE 368
Query: 421 AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI----TILFDALITQY 476
T ++++ ++LKE + +K+ + + ++D K+ T L A
Sbjct: 369 GETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAD 428
Query: 477 ELSRTDYEI-----EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
++ + ++ E E+++ AK + D LE H ++K L E+
Sbjct: 429 QIRKNCQDMIKTYQESEEIKSNELDAK-LRVTKGELEKQMQEKSDQLEMHHAKIKEL-ED 486
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + +K +DE +K L +E + ++K +E + + L + V T + L
Sbjct: 487 LKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQL 546
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+E+ K + + E E+ S + + I+ + K ++++L+
Sbjct: 547 QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS----RKRESELLLFTERLTSKNAQL 602
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH-EKTAEIQNRMIMRLQKQIQED 710
+ +S ++ + Q + + + IN+++ K E++ + LQ ++
Sbjct: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAEL--- 659
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI 770
++T++ L+ + E LK D V ++ LT Q ++ ++ES
Sbjct: 660 ----ACRQTEVKALSTQVEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGS 712
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
++ +++ EN G + +D+ P+ +
Sbjct: 713 YDKEVSSMGSRSSSSGSLNARSSAEDR----SPEN--TGSSVAVDNFPQ--------VDK 758
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE--QCARLKKEKLSLEQQVSN 888
+ L ER++ Q+ E+ + ++D + E ++++ + Q L++E +L + S+
Sbjct: 759 AMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASD 818
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++ R A + + D + ++ + +E N++L +E+
Sbjct: 819 FNKVHLSR----RGGIMASLYTSHPAD---------NGLTLELSLEINRKLQAVLEDTLL 865
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
K LK + + +E+ K E E + K+
Sbjct: 866 KNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
Score = 51.6 bits (118), Expect = 2e-05
Identities = 145/747 (19%), Positives = 299/747 (40%), Gaps = 68/747 (9%)
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
K + D + I +L +EN L ++ +E DNL +E LKK E Q ++
Sbjct: 196 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQHMNTIK 252
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+L E++I N + K + + + + N + +L++ + + + NK C
Sbjct: 253 QL----ESRIEELN--KEVKASRDQLIAQDVTAKNAVQQLHKEM--AQRMEQANKKCE-- 302
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFE--TKAVKVMSEIK 303
+A +E + + K L+L + T L++KL + N E E T +K +S+ K
Sbjct: 303 ---EARQEKEAMVMKYVRGEKESLDLRKEKET--LEKKLRDANKELEKNTNKIKQLSQEK 357
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLA-VLDAEFGTTSLDVFEILMDNIINKYQID 362
L+ L E E+ + ID+ K+ + + V+ ++ L + MD+ ++
Sbjct: 358 GRLHQLYETK-EGETTRLIREIDKLKEDINSHVIKVKWAQNKL---KAEMDS----HKET 409
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSA 421
D++ E TK+ E K+ + + + K N + LR+ K + +
Sbjct: 410 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK---- 465
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD-ALITQYELSR 480
+ +K ++L E+ + +L LK +D+ K+ L D L T+ ELS+
Sbjct: 466 ---QMQEKSDQL-EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 481 TDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
I ++K ++ K +E EV+SL+ + L K +
Sbjct: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK--QEIENLKEEVESLNSLINDLQKD-I 578
Query: 541 DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN-KLTELVSTINGLKEENNSLK 599
+ + + + + +E + + + + S +K + ++L S +K+ N +L+
Sbjct: 579 EGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE 638
Query: 600 S--LNDVITREKETQASELERSCQ--VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
S L + R++E Q + E +C+ +K +++++K +++
Sbjct: 639 SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQL 698
Query: 656 DEAKSLLEQ---NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR-MIMRLQKQIQEDD 711
+A+ L+Q KE +R S +N ++ + +N + + Q D
Sbjct: 699 QQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDK 758
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ IE+ +L K A K + +E + + QL + + + ++S I
Sbjct: 759 AMLIERIVRL----QKAHARKNE------KIEFMEDHIKQLVEE---IRKKTKIIQSYIL 805
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI-SVISDSEV 830
E++ T+ + D G +L R + +V+ D+ +
Sbjct: 806 REESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLL 865
Query: 831 SQ--LKERLLSCQQELDDLKERYKELD 855
LKE L + E++ L + EL+
Sbjct: 866 KNITLKENLQTLGTEIERLIKHQHELE 892
Score = 49.6 bits (113), Expect = 6e-05
Identities = 95/504 (18%), Positives = 207/504 (41%), Gaps = 38/504 (7%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS-EK 577
+E ++ S + L + K + + ++N IK L I+ L + + +++++
Sbjct: 220 QELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTA 279
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N + +L + E+ N K + +EKE + R ++ +L K K +
Sbjct: 280 KNAVQQLHKEMAQRMEQAN--KKCEEA-RQEKEAMVMKYVRG----EKESLDLRKEKETL 332
Query: 638 ---LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE-QCEEKTRDCSRLEINIKTHE-KT 692
L + K L Q KE + R+ +L+ +I +H K
Sbjct: 333 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 392
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV-NQ 751
QN++ + + DKL E TKL + + + ++++ +K + S E N+
Sbjct: 393 KWAQNKLKAEMDSHKETKDKLK-ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 451
Query: 752 LTTQKDLVEGRIAEL---ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDE 804
L + + +G + + +SD A + T DE
Sbjct: 452 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE 511
Query: 805 NR----DLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDEC 858
+L + ++ + K I + D QL+E+L +QE+++LKE + L+
Sbjct: 512 RLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLN--- 568
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ LQ+ E + + E L +++++ Q++++ Q++F V+ + + +
Sbjct: 569 -SLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESN-SLQSQFDKVSCSESQLQSQ 626
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK--KDKEFEA 976
+ ++ ++ + K + L K EE++ + +L T++ KA+ + KD+
Sbjct: 627 CEQMKQTNINLESRLLKEEELRK--EEVQTLQAELACRQTEV-KALSTQVEELKDELVTQ 683
Query: 977 KRKELEDCKAELEELKQRYKELDE 1000
+RK K ++L+Q ++LD+
Sbjct: 684 RRKHASSIKDLTKQLQQARRKLDQ 707
Score = 47.2 bits (107), Expect = 3e-04
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 19/229 (8%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ + D ++Q + QQ ++ +R ++ + +CE + + + R +KE
Sbjct: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
L L ++ L++++R + K + ++ LH + Y+ + + RL
Sbjct: 323 LDLRKEKETLEKKLRDAN--KELEKNTNKIKQLSQEKGRLHQL------YETKEGETTRL 374
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
++ I++L K+D+ + V K++ A K E ++ ++ + K +L Q +E D
Sbjct: 375 IREIDKL---KEDINSHVIKVKWAQNKL---KAEMDSHKETKDKLKETTTKLTQAKEEAD 428
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + C + +K +E +E K + E+ KL K LEKQ++ S+
Sbjct: 429 QIRKNCQDMIKTYQES----EEIK-SNELDAKLRVTKGELEKQMQEKSD 472
Score = 46.4 bits (105), Expect = 6e-04
Identities = 66/335 (19%), Positives = 148/335 (44%), Gaps = 27/335 (8%)
Query: 86 EQKSALEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSL-KTKSKKINEL 143
++++ E ++ N I + ++R + L ++K+ + + +D KN L K ++++ +
Sbjct: 238 KKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQA 297
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
++ + V + KE DL+K E L +K D K + ++ NKI K +
Sbjct: 298 NKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKI--KQLSQ 355
Query: 204 QCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC--TLQSELDAGRE---DCKE 258
+ L ++ + ++++ D N+ K L++E+D+ +E KE
Sbjct: 356 EKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE 415
Query: 259 LCEDFTSIKNHLELHEPN-----MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
T K + N T E++ ++NE + K E+++ + S+QL
Sbjct: 416 TTTKLTQAKEEADQIRKNCQDMIKTYQESEEI-KSNELDAKLRVTKGELEKQMQEKSDQL 474
Query: 314 INNESK-KSKDHIDR-YKDSLLAVLDAEFGTTSLDVFEILMDN-------IINKYQIDLD 364
+ +K K + + R +K+ + + L+ + ++ IIN+ + ++
Sbjct: 475 EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQ 534
Query: 365 EILEKY---TKVQGDLNECTSELKSVNEKLASLNS 396
+L+K ++Q L E++++ E++ SLNS
Sbjct: 535 NLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS 569
Score = 41.9 bits (94), Expect = 0.012
Identities = 71/347 (20%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME---NLT 121
+S E KL++ + +L KE+ + Q++I Q + +IKS E++ +T
Sbjct: 404 DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESE----EIKSNELDAKLRVT 459
Query: 122 K---DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
K +K+++ +D L+ KI EL++ L E + E L +V L+
Sbjct: 460 KGELEKQMQEKSDQLEMHHAKIKELED----LKRTFKEGMDELRTLRTKVKCLEDERLRT 515
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ ++++N + +I +N+ + K + L + L G + L + N+
Sbjct: 516 EDELSKYKEIINRQKAEI--QNLLDKVKTADQLQEQLQRGKQE-IENLKEEVESLNSL-- 570
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
I LQ +++ R+ EL L +T + E+N +++ KV
Sbjct: 571 ---INDLQKDIEGSRKRESELL-----------LFTERLTSKNAQLQSESNSLQSQFDKV 616
Query: 299 M---SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
S+++ + + IN ES+ K+ R ++ + L AE +V +
Sbjct: 617 SCSESQLQSQCEQMKQTNINLESRLLKEEELRKEE--VQTLQAELACRQTEVKALSTQ-- 672
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + + DE++ + K + + T +L+ KL + S +KE
Sbjct: 673 VEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 716
Score = 41.5 bits (93), Expect = 0.016
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 48/286 (16%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL-QDSGTITISCK-MCQSLKES----SNEINLKLEKLSG 79
++D K D + ET + + +++ I +C+ M ++ +ES SNE++ KL G
Sbjct: 402 EMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKG 461
Query: 80 ELFDIKEQKS-ALEGKYQNLI-LETQTRDL---------LMSQIKSLEMENL-TKDK--- 124
EL ++KS LE + + LE R L +++K LE E L T+D+
Sbjct: 462 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 125 ----------EIKNLTDSLKTK----------SKKINELQEENDTLSNLIMENVTESDNL 164
EI+NL D +KT ++I L+EE ++L++LI + + +
Sbjct: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS 581
Query: 165 NKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLS 224
K +L E LT K L+ N +++ K C++ +L+ Q N S
Sbjct: 582 RKRESELLLFTERLTSKNAQLQSESNSLQSQF-DKVSCSESQLQSQCEQMKQTNI-NLES 639
Query: 225 KLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+L + R ++ TLQ+EL + + K L +K+ L
Sbjct: 640 RLLK-----EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL 680
Score = 35.9 bits (79), Expect = 0.80
Identities = 86/423 (20%), Positives = 173/423 (40%), Gaps = 45/423 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ--NLILETQTRDLL-MSQIKS 114
K C+ ++ + +K + E D++++K LE K + N LE T + +SQ K
Sbjct: 299 KKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKG 358
Query: 115 -LEMENLTKD-------KEIKNLTDSLKTKSKKI----NELQEENDT---LSNLIMENVT 159
L TK+ +EI L + + + K+ N+L+ E D+ + + E T
Sbjct: 359 RLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTT 418
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE----NKIGPKNICAQCKLKENLIQ-- 213
+ +E D ++KN C D+ K ESE N++ K + +L++ + +
Sbjct: 419 KLTQAKEEADQIRKN-------CQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKS 471
Query: 214 ---SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+H L L R+ + R + T L+ R ++ + I N
Sbjct: 472 DQLEMHHAKIKELEDLKRTFKEGMDELR--TLRTKVKCLEDERLRTEDELSKYKEIINRQ 529
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ N+ +D + + E + + + +K + SL+ LIN+ K + R +
Sbjct: 530 KAEIQNL-LDKVKTADQLQEQLQRGKQEIENLKEEVESLN-SLINDLQKDIEGSRKRESE 587
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV-QGDLNECTSELKSVNE 389
LL L + + +K ++ + ++ Q ++N + LK E
Sbjct: 588 LLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK--EE 645
Query: 390 KLASLNSQLIEKENACNILRIQ--KERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
+L Q ++ E AC ++ ++ E+ + K + +K+ LTK+ L+ ++
Sbjct: 646 ELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKD-LTKQ-LQQARR 703
Query: 448 KID 450
K+D
Sbjct: 704 KLD 706
>BC103499-1|AAI03500.1| 898|Homo sapiens chromosome 10 open reading
frame 118 protein.
Length = 898
Score = 67.3 bits (157), Expect = 3e-10
Identities = 109/556 (19%), Positives = 237/556 (42%), Gaps = 43/556 (7%)
Query: 531 ELTKLYKSKVDENNANLNLIK-----ILSEEIDALKIAIAKNE-EKMLSLSEK--DNKLT 582
+ TK + SK+ +A+ +L++ +LS E ++ N+ E L L EK +K
Sbjct: 144 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYL 203
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ I L +EN + L I EK+ EL++ + KQ+ + ++++ I
Sbjct: 204 QQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK 263
Query: 643 XXXXXXXXXXXXXDEAKSLLEQ---NLALK-----EQCEEKTRDCSRLEINIKTHEKTAE 694
AK+ ++Q +A + ++CEE ++ + + EK +
Sbjct: 264 EVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL 323
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAAVKDLESSRE 747
+ L+K++++ +K + K+ +L+ + YE + + +++++ +E
Sbjct: 324 DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKE 383
Query: 748 AVNQLTTQKDLVEGRI-AELESDIRTE---QTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+N + + ++ AE++S T+ + T T+
Sbjct: 384 DINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY-Q 442
Query: 804 ENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECET- 860
E+ ++ N +LD + + + E S E + +EL+DLK +KE DE T
Sbjct: 443 ESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTL 501
Query: 861 -----CAEYLQERDEQCARLKKEKLSLEQ-QVSNLKEQIRTQQPVERQAKFADVAV-NTD 913
C E + R E KE ++ ++ ++ NL ++++T ++ Q + + N
Sbjct: 502 RTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLK 561
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ +L+S++ D + + ++ L+ E L K L++ +Q +K + +
Sbjct: 562 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSES 621
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
+ +++ ++++ LE + +EL EE +T L R+ + K L E+ D+
Sbjct: 622 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQ--VEELKDE 679
Query: 1032 LSNQKVALEKQIESLS 1047
L Q+ I+ L+
Sbjct: 680 LVTQRRKHASSIKDLT 695
Score = 51.6 bits (118), Expect = 2e-05
Identities = 145/747 (19%), Positives = 299/747 (40%), Gaps = 68/747 (9%)
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
K + D + I +L +EN L ++ +E DNL +E LKK E Q ++
Sbjct: 196 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQHMNTIK 252
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+L E++I N + K + + + + N + +L++ + + + NK C
Sbjct: 253 QL----ESRIEELN--KEVKASRDKLIAQDVTAKNAVQQLHKEM--AQRMEQANKKCE-- 302
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFE--TKAVKVMSEIK 303
+A +E + + K L+L + T L++KL + N E E T +K +S+ K
Sbjct: 303 ---EARQEKEAMVMKYVRGEKESLDLRKEKET--LEKKLRDANKELEKNTNKIKQLSQEK 357
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLA-VLDAEFGTTSLDVFEILMDNIINKYQID 362
L+ L E E+ + ID+ K+ + + V+ ++ L + MD+ ++
Sbjct: 358 GRLHQLYETK-EGETTRLIREIDKLKEDINSHVIKVKWAQNKL---KAEMDS----HKET 409
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSA 421
D++ E TK+ E K+ + + + K N + LR+ K + +
Sbjct: 410 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK---- 465
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD-ALITQYELSR 480
+ +K ++L E+ + +L LK +D+ K+ L D L T+ ELS+
Sbjct: 466 ---QMQEKSDQL-EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 481 TDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
I ++K ++ K +E EV+SL+ + L K +
Sbjct: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK--QEIENLKEEVESLNSLINDLQKD-I 578
Query: 541 DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN-KLTELVSTINGLKEENNSLK 599
+ + + + + +E + + + + S +K + ++L S +K+ N +L+
Sbjct: 579 EGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE 638
Query: 600 S--LNDVITREKETQASELERSCQ--VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
S L + R++E Q + E +C+ +K +++++K +++
Sbjct: 639 SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQL 698
Query: 656 DEAKSLLEQ---NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR-MIMRLQKQIQEDD 711
+A+ L+Q KE +R S +N ++ + +N + + Q D
Sbjct: 699 QQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDK 758
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ IE+ +L K A K + +E + + QL + + + ++S I
Sbjct: 759 AMLIERIVRL----QKAHARKNE------KIEFMEDHIKQLVEE---IRKKTKIIQSYIL 805
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI-SVISDSEV 830
E++ T+ + D G +L R + +V+ D+ +
Sbjct: 806 REESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLL 865
Query: 831 SQ--LKERLLSCQQELDDLKERYKELD 855
LKE L + E++ L + EL+
Sbjct: 866 KNITLKENLQTLGTEIERLIKHQHELE 892
Score = 51.2 bits (117), Expect = 2e-05
Identities = 96/504 (19%), Positives = 207/504 (41%), Gaps = 38/504 (7%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS-EK 577
+E ++ S + L + K + + ++N IK L I+ L + + +K+++
Sbjct: 220 QELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDKLIAQDVTA 279
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N + +L + E+ N K + +EKE + R ++ +L K K +
Sbjct: 280 KNAVQQLHKEMAQRMEQAN--KKCEEA-RQEKEAMVMKYVRG----EKESLDLRKEKETL 332
Query: 638 ---LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE-QCEEKTRDCSRLEINIKTHE-KT 692
L + K L Q KE + R+ +L+ +I +H K
Sbjct: 333 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 392
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV-NQ 751
QN++ + + DKL E TKL + + + ++++ +K + S E N+
Sbjct: 393 KWAQNKLKAEMDSHKETKDKLK-ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 451
Query: 752 LTTQKDLVEGRIAEL---ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDE 804
L + + +G + + +SD A + T DE
Sbjct: 452 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE 511
Query: 805 NR----DLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDEC 858
+L + ++ + K I + D QL+E+L +QE+++LKE + L+
Sbjct: 512 RLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLN--- 568
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ LQ+ E + + E L +++++ Q++++ Q++F V+ + + +
Sbjct: 569 -SLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESN-SLQSQFDKVSCSESQLQSQ 626
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK--KDKEFEA 976
+ ++ ++ + K + L K EE++ + +L T++ KA+ + KD+
Sbjct: 627 CEQMKQTNINLESRLLKEEELRK--EEVQTLQAELACRQTEV-KALSTQVEELKDELVTQ 683
Query: 977 KRKELEDCKAELEELKQRYKELDE 1000
+RK K ++L+Q ++LD+
Sbjct: 684 RRKHASSIKDLTKQLQQARRKLDQ 707
Score = 47.2 bits (107), Expect = 3e-04
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 19/229 (8%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ + D ++Q + QQ ++ +R ++ + +CE + + + R +KE
Sbjct: 263 KEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
L L ++ L++++R + K + ++ LH + Y+ + + RL
Sbjct: 323 LDLRKEKETLEKKLRDAN--KELEKNTNKIKQLSQEKGRLHQL------YETKEGETTRL 374
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
++ I++L K+D+ + V K++ A K E ++ ++ + K +L Q +E D
Sbjct: 375 IREIDKL---KEDINSHVIKVKWAQNKL---KAEMDSHKETKDKLKETTTKLTQAKEEAD 428
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + C + +K +E +E K + E+ KL K LEKQ++ S+
Sbjct: 429 QIRKNCQDMIKTYQES----EEIK-SNELDAKLRVTKGELEKQMQEKSD 472
Score = 46.0 bits (104), Expect = 8e-04
Identities = 66/335 (19%), Positives = 148/335 (44%), Gaps = 27/335 (8%)
Query: 86 EQKSALEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSL-KTKSKKINEL 143
++++ E ++ N I + ++R + L ++K+ + + +D KN L K ++++ +
Sbjct: 238 KKRTETEKQHMNTIKQLESRIEELNKEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQA 297
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
++ + V + KE DL+K E L +K D K + ++ NKI K +
Sbjct: 298 NKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKI--KQLSQ 355
Query: 204 QCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC--TLQSELDAGRE---DCKE 258
+ L ++ + ++++ D N+ K L++E+D+ +E KE
Sbjct: 356 EKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE 415
Query: 259 LCEDFTSIKNHLELHEPN-----MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
T K + N T E++ ++NE + K E+++ + S+QL
Sbjct: 416 TTTKLTQAKEEADQIRKNCQDMIKTYQESEEI-KSNELDAKLRVTKGELEKQMQEKSDQL 474
Query: 314 INNESK-KSKDHIDR-YKDSLLAVLDAEFGTTSLDVFEILMDN-------IINKYQIDLD 364
+ +K K + + R +K+ + + L+ + ++ IIN+ + ++
Sbjct: 475 EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQ 534
Query: 365 EILEKY---TKVQGDLNECTSELKSVNEKLASLNS 396
+L+K ++Q L E++++ E++ SLNS
Sbjct: 535 NLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS 569
Score = 41.9 bits (94), Expect = 0.012
Identities = 71/347 (20%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME---NLT 121
+S E KL++ + +L KE+ + Q++I Q + +IKS E++ +T
Sbjct: 404 DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESE----EIKSNELDAKLRVT 459
Query: 122 K---DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
K +K+++ +D L+ KI EL++ L E + E L +V L+
Sbjct: 460 KGELEKQMQEKSDQLEMHHAKIKELED----LKRTFKEGMDELRTLRTKVKCLEDERLRT 515
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ ++++N + +I +N+ + K + L + L G + L + N+
Sbjct: 516 EDELSKYKEIINRQKAEI--QNLLDKVKTADQLQEQLQRGKQE-IENLKEEVESLNSL-- 570
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
I LQ +++ R+ EL L +T + E+N +++ KV
Sbjct: 571 ---INDLQKDIEGSRKRESELL-----------LFTERLTSKNAQLQSESNSLQSQFDKV 616
Query: 299 M---SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
S+++ + + IN ES+ K+ R ++ + L AE +V +
Sbjct: 617 SCSESQLQSQCEQMKQTNINLESRLLKEEELRKEE--VQTLQAELACRQTEVKALSTQ-- 672
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + + DE++ + K + + T +L+ KL + S +KE
Sbjct: 673 VEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 716
Score = 41.5 bits (93), Expect = 0.016
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 48/286 (16%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL-QDSGTITISCK-MCQSLKES----SNEINLKLEKLSG 79
++D K D + ET + + +++ I +C+ M ++ +ES SNE++ KL G
Sbjct: 402 EMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKG 461
Query: 80 ELFDIKEQKS-ALEGKYQNLI-LETQTRDL---------LMSQIKSLEMENL-TKDK--- 124
EL ++KS LE + + LE R L +++K LE E L T+D+
Sbjct: 462 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
Query: 125 ----------EIKNLTDSLKTK----------SKKINELQEENDTLSNLIMENVTESDNL 164
EI+NL D +KT ++I L+EE ++L++LI + + +
Sbjct: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS 581
Query: 165 NKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLS 224
K +L E LT K L+ N +++ K C++ +L+ Q N S
Sbjct: 582 RKRESELLLFTERLTSKNAQLQSESNSLQSQF-DKVSCSESQLQSQCEQMKQTNI-NLES 639
Query: 225 KLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+L + R ++ TLQ+EL + + K L +K+ L
Sbjct: 640 RLLK-----EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL 680
Score = 35.9 bits (79), Expect = 0.80
Identities = 86/423 (20%), Positives = 173/423 (40%), Gaps = 45/423 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ--NLILETQTRDLL-MSQIKS 114
K C+ ++ + +K + E D++++K LE K + N LE T + +SQ K
Sbjct: 299 KKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKG 358
Query: 115 -LEMENLTKD-------KEIKNLTDSLKTKSKKI----NELQEENDT---LSNLIMENVT 159
L TK+ +EI L + + + K+ N+L+ E D+ + + E T
Sbjct: 359 RLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTT 418
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE----NKIGPKNICAQCKLKENLIQ-- 213
+ +E D ++KN C D+ K ESE N++ K + +L++ + +
Sbjct: 419 KLTQAKEEADQIRKN-------CQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKS 471
Query: 214 ---SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+H L L R+ + R + T L+ R ++ + I N
Sbjct: 472 DQLEMHHAKIKELEDLKRTFKEGMDELR--TLRTKVKCLEDERLRTEDELSKYKEIINRQ 529
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ N+ +D + + E + + + +K + SL+ LIN+ K + R +
Sbjct: 530 KAEIQNL-LDKVKTADQLQEQLQRGKQEIENLKEEVESLN-SLINDLQKDIEGSRKRESE 587
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV-QGDLNECTSELKSVNE 389
LL L + + +K ++ + ++ Q ++N + LK E
Sbjct: 588 LLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK--EE 645
Query: 390 KLASLNSQLIEKENACNILRIQ--KERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
+L Q ++ E AC ++ ++ E+ + K + +K+ LTK+ L+ ++
Sbjct: 646 ELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKD-LTKQ-LQQARR 703
Query: 448 KID 450
K+D
Sbjct: 704 KLD 706
>BC100670-1|AAI00671.1| 1004|Homo sapiens C10orf118 protein protein.
Length = 1004
Score = 67.3 bits (157), Expect = 3e-10
Identities = 109/556 (19%), Positives = 237/556 (42%), Gaps = 43/556 (7%)
Query: 531 ELTKLYKSKVDENNANLNLIK-----ILSEEIDALKIAIAKNE-EKMLSLSEK--DNKLT 582
+ TK + SK+ +A+ +L++ +LS E ++ N+ E L L EK +K
Sbjct: 250 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYL 309
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
+ I L +EN + L I EK+ EL++ + KQ+ + ++++ I
Sbjct: 310 QQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK 369
Query: 643 XXXXXXXXXXXXXDEAKSLLEQ---NLALK-----EQCEEKTRDCSRLEINIKTHEKTAE 694
AK+ ++Q +A + ++CEE ++ + + EK +
Sbjct: 370 EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL 429
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK-------YEALKRDYDAAVKDLESSRE 747
+ L+K++++ +K + K+ +L+ + YE + + +++++ +E
Sbjct: 430 DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKE 489
Query: 748 AVNQLTTQKDLVEGRI-AELESDIRTE---QTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+N + + ++ AE++S T+ + T T+
Sbjct: 490 DINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY-Q 548
Query: 804 ENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECET- 860
E+ ++ N +LD + + + E S E + +EL+DLK +KE DE T
Sbjct: 549 ESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTL 607
Query: 861 -----CAEYLQERDEQCARLKKEKLSLEQ-QVSNLKEQIRTQQPVERQAKFADVAV-NTD 913
C E + R E KE ++ ++ ++ NL ++++T ++ Q + + N
Sbjct: 608 RTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLK 667
Query: 914 EDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ +L+S++ D + + ++ L+ E L K L++ +Q +K + +
Sbjct: 668 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSES 727
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL-DEECETCAEYLKQREEQCKRLKEAKIALEIVDK 1031
+ +++ ++++ LE + +EL EE +T L R+ + K L E+ D+
Sbjct: 728 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQ--VEELKDE 785
Query: 1032 LSNQKVALEKQIESLS 1047
L Q+ I+ L+
Sbjct: 786 LVTQRRKHASSIKDLT 801
Score = 55.6 bits (128), Expect = 9e-07
Identities = 106/632 (16%), Positives = 253/632 (40%), Gaps = 58/632 (9%)
Query: 364 DEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI---SS 420
+ ++ KY + + + + E +++ +KL N +L + N L +K R+H++
Sbjct: 415 EAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKE 474
Query: 421 AVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI----TILFDALITQY 476
T ++++ ++LKE + +K+ + + ++D K+ T L A
Sbjct: 475 GETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAD 534
Query: 477 ELSRTDYEI-----EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
++ + ++ E E+++ AK + D LE H ++K L E+
Sbjct: 535 QIRKNCQDMIKTYQESEEIKSNELDAK-LRVTKGELEKQMQEKSDQLEMHHAKIKEL-ED 592
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL 591
L + +K +DE +K L +E + ++K +E + + L + V T + L
Sbjct: 593 LKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQL 652
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+E+ K + + E E+ S + + I+ + K ++++L+
Sbjct: 653 QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS----RKRESELLLFTERLTSKNAQL 708
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH-EKTAEIQNRMIMRLQKQIQED 710
+ +S ++ + Q + + + IN+++ K E++ + LQ ++
Sbjct: 709 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAEL--- 765
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI 770
++T++ L+ + E LK D V ++ LT Q ++ ++ES
Sbjct: 766 ----ACRQTEVKALSTQVEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGS 818
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
++ +++ EN G + +D+ P+ +
Sbjct: 819 YDKEVSSMGSRSSSSGSLNARSSAEDR----SPEN--TGSSVAVDNFPQ--------VDK 864
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE--QCARLKKEKLSLEQQVSN 888
+ L ER++ Q+ E+ + ++D + E ++++ + Q L++E +L + S+
Sbjct: 865 AMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASD 924
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
+ ++ R A + + D + ++ + +E N++L +E+
Sbjct: 925 FNKVHLSR----RGGIMASLYTSHPAD---------NGLTLELSLEINRKLQAVLEDTLL 971
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
K LK + + +E+ K E E + K+
Sbjct: 972 KNITLKENLQTLGTEIERLIKHQHELEQRTKK 1003
Score = 51.6 bits (118), Expect = 2e-05
Identities = 145/747 (19%), Positives = 299/747 (40%), Gaps = 68/747 (9%)
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
K + D + I +L +EN L ++ +E DNL +E LKK E Q ++
Sbjct: 302 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQHMNTIK 358
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+L E++I N + K + + + + N + +L++ + + + NK C
Sbjct: 359 QL----ESRIEELN--KEVKASRDQLIAQDVTAKNAVQQLHKEM--AQRMEQANKKCE-- 408
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFE--TKAVKVMSEIK 303
+A +E + + K L+L + T L++KL + N E E T +K +S+ K
Sbjct: 409 ---EARQEKEAMVMKYVRGEKESLDLRKEKET--LEKKLRDANKELEKNTNKIKQLSQEK 463
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLA-VLDAEFGTTSLDVFEILMDNIINKYQID 362
L+ L E E+ + ID+ K+ + + V+ ++ L + MD+ ++
Sbjct: 464 GRLHQLYETK-EGETTRLIREIDKLKEDINSHVIKVKWAQNKL---KAEMDS----HKET 515
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSA 421
D++ E TK+ E K+ + + + K N + LR+ K + +
Sbjct: 516 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK---- 571
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD-ALITQYELSR 480
+ +K ++L E+ + +L LK +D+ K+ L D L T+ ELS+
Sbjct: 572 ---QMQEKSDQL-EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 627
Query: 481 TDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
I ++K ++ K +E EV+SL+ + L K +
Sbjct: 628 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK--QEIENLKEEVESLNSLINDLQKD-I 684
Query: 541 DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN-KLTELVSTINGLKEENNSLK 599
+ + + + + +E + + + + S +K + ++L S +K+ N +L+
Sbjct: 685 EGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE 744
Query: 600 S--LNDVITREKETQASELERSCQ--VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
S L + R++E Q + E +C+ +K +++++K +++
Sbjct: 745 SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQL 804
Query: 656 DEAKSLLEQ---NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR-MIMRLQKQIQEDD 711
+A+ L+Q KE +R S +N ++ + +N + + Q D
Sbjct: 805 QQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDK 864
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ IE+ +L K A K + +E + + QL + + + ++S I
Sbjct: 865 AMLIERIVRL----QKAHARKNE------KIEFMEDHIKQLVEE---IRKKTKIIQSYIL 911
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI-SVISDSEV 830
E++ T+ + D G +L R + +V+ D+ +
Sbjct: 912 REESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLL 971
Query: 831 SQ--LKERLLSCQQELDDLKERYKELD 855
LKE L + E++ L + EL+
Sbjct: 972 KNITLKENLQTLGTEIERLIKHQHELE 998
Score = 49.6 bits (113), Expect = 6e-05
Identities = 95/504 (18%), Positives = 207/504 (41%), Gaps = 38/504 (7%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS-EK 577
+E ++ S + L + K + + ++N IK L I+ L + + +++++
Sbjct: 326 QELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTA 385
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N + +L + E+ N K + +EKE + R ++ +L K K +
Sbjct: 386 KNAVQQLHKEMAQRMEQAN--KKCEEA-RQEKEAMVMKYVRG----EKESLDLRKEKETL 438
Query: 638 ---LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE-QCEEKTRDCSRLEINIKTHE-KT 692
L + K L Q KE + R+ +L+ +I +H K
Sbjct: 439 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 498
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV-NQ 751
QN++ + + DKL E TKL + + + ++++ +K + S E N+
Sbjct: 499 KWAQNKLKAEMDSHKETKDKLK-ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 557
Query: 752 LTTQKDLVEGRIAEL---ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDE 804
L + + +G + + +SD A + T DE
Sbjct: 558 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE 617
Query: 805 NR----DLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDEC 858
+L + ++ + K I + D QL+E+L +QE+++LKE + L+
Sbjct: 618 RLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLN--- 674
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ LQ+ E + + E L +++++ Q++++ Q++F V+ + + +
Sbjct: 675 -SLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESN-SLQSQFDKVSCSESQLQSQ 732
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK--KDKEFEA 976
+ ++ ++ + K + L K EE++ + +L T++ KA+ + KD+
Sbjct: 733 CEQMKQTNINLESRLLKEEELRK--EEVQTLQAELACRQTEV-KALSTQVEELKDELVTQ 789
Query: 977 KRKELEDCKAELEELKQRYKELDE 1000
+RK K ++L+Q ++LD+
Sbjct: 790 RRKHASSIKDLTKQLQQARRKLDQ 813
Score = 47.2 bits (107), Expect = 3e-04
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 19/229 (8%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ + D ++Q + QQ ++ +R ++ + +CE + + + R +KE
Sbjct: 369 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 428
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
L L ++ L++++R + K + ++ LH + Y+ + + RL
Sbjct: 429 LDLRKEKETLEKKLRDAN--KELEKNTNKIKQLSQEKGRLHQL------YETKEGETTRL 480
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
++ I++L K+D+ + V K++ A K E ++ ++ + K +L Q +E D
Sbjct: 481 IREIDKL---KEDINSHVIKVKWAQNKL---KAEMDSHKETKDKLKETTTKLTQAKEEAD 534
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + C + +K +E +E K + E+ KL K LEKQ++ S+
Sbjct: 535 QIRKNCQDMIKTYQES----EEIK-SNELDAKLRVTKGELEKQMQEKSD 578
Score = 46.4 bits (105), Expect = 6e-04
Identities = 66/335 (19%), Positives = 148/335 (44%), Gaps = 27/335 (8%)
Query: 86 EQKSALEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSL-KTKSKKINEL 143
++++ E ++ N I + ++R + L ++K+ + + +D KN L K ++++ +
Sbjct: 344 KKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQA 403
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
++ + V + KE DL+K E L +K D K + ++ NKI K +
Sbjct: 404 NKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKI--KQLSQ 461
Query: 204 QCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC--TLQSELDAGRE---DCKE 258
+ L ++ + ++++ D N+ K L++E+D+ +E KE
Sbjct: 462 EKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE 521
Query: 259 LCEDFTSIKNHLELHEPN-----MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
T K + N T E++ ++NE + K E+++ + S+QL
Sbjct: 522 TTTKLTQAKEEADQIRKNCQDMIKTYQESEEI-KSNELDAKLRVTKGELEKQMQEKSDQL 580
Query: 314 INNESK-KSKDHIDR-YKDSLLAVLDAEFGTTSLDVFEILMDN-------IINKYQIDLD 364
+ +K K + + R +K+ + + L+ + ++ IIN+ + ++
Sbjct: 581 EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQ 640
Query: 365 EILEKY---TKVQGDLNECTSELKSVNEKLASLNS 396
+L+K ++Q L E++++ E++ SLNS
Sbjct: 641 NLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS 675
Score = 41.9 bits (94), Expect = 0.012
Identities = 71/347 (20%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME---NLT 121
+S E KL++ + +L KE+ + Q++I Q + +IKS E++ +T
Sbjct: 510 DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESE----EIKSNELDAKLRVT 565
Query: 122 K---DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
K +K+++ +D L+ KI EL++ L E + E L +V L+
Sbjct: 566 KGELEKQMQEKSDQLEMHHAKIKELED----LKRTFKEGMDELRTLRTKVKCLEDERLRT 621
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ ++++N + +I +N+ + K + L + L G + L + N+
Sbjct: 622 EDELSKYKEIINRQKAEI--QNLLDKVKTADQLQEQLQRGKQE-IENLKEEVESLNSL-- 676
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
I LQ +++ R+ EL L +T + E+N +++ KV
Sbjct: 677 ---INDLQKDIEGSRKRESELL-----------LFTERLTSKNAQLQSESNSLQSQFDKV 722
Query: 299 M---SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
S+++ + + IN ES+ K+ R ++ + L AE +V +
Sbjct: 723 SCSESQLQSQCEQMKQTNINLESRLLKEEELRKEE--VQTLQAELACRQTEVKALSTQ-- 778
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + + DE++ + K + + T +L+ KL + S +KE
Sbjct: 779 VEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 822
Score = 41.5 bits (93), Expect = 0.016
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 48/286 (16%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL-QDSGTITISCK-MCQSLKES----SNEINLKLEKLSG 79
++D K D + ET + + +++ I +C+ M ++ +ES SNE++ KL G
Sbjct: 508 EMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKG 567
Query: 80 ELFDIKEQKS-ALEGKYQNLI-LETQTRDL---------LMSQIKSLEMENL-TKDK--- 124
EL ++KS LE + + LE R L +++K LE E L T+D+
Sbjct: 568 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 627
Query: 125 ----------EIKNLTDSLKTK----------SKKINELQEENDTLSNLIMENVTESDNL 164
EI+NL D +KT ++I L+EE ++L++LI + + +
Sbjct: 628 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS 687
Query: 165 NKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLS 224
K +L E LT K L+ N +++ K C++ +L+ Q N S
Sbjct: 688 RKRESELLLFTERLTSKNAQLQSESNSLQSQF-DKVSCSESQLQSQCEQMKQTNI-NLES 745
Query: 225 KLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+L + R ++ TLQ+EL + + K L +K+ L
Sbjct: 746 RLLK-----EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL 786
Score = 35.9 bits (79), Expect = 0.80
Identities = 86/423 (20%), Positives = 173/423 (40%), Gaps = 45/423 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ--NLILETQTRDLL-MSQIKS 114
K C+ ++ + +K + E D++++K LE K + N LE T + +SQ K
Sbjct: 405 KKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKG 464
Query: 115 -LEMENLTKD-------KEIKNLTDSLKTKSKKI----NELQEENDT---LSNLIMENVT 159
L TK+ +EI L + + + K+ N+L+ E D+ + + E T
Sbjct: 465 RLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTT 524
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE----NKIGPKNICAQCKLKENLIQ-- 213
+ +E D ++KN C D+ K ESE N++ K + +L++ + +
Sbjct: 525 KLTQAKEEADQIRKN-------CQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKS 577
Query: 214 ---SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+H L L R+ + R + T L+ R ++ + I N
Sbjct: 578 DQLEMHHAKIKELEDLKRTFKEGMDELR--TLRTKVKCLEDERLRTEDELSKYKEIINRQ 635
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ N+ +D + + E + + + +K + SL+ LIN+ K + R +
Sbjct: 636 KAEIQNL-LDKVKTADQLQEQLQRGKQEIENLKEEVESLN-SLINDLQKDIEGSRKRESE 693
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV-QGDLNECTSELKSVNE 389
LL L + + +K ++ + ++ Q ++N + LK E
Sbjct: 694 LLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK--EE 751
Query: 390 KLASLNSQLIEKENACNILRIQ--KERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
+L Q ++ E AC ++ ++ E+ + K + +K+ LTK+ L+ ++
Sbjct: 752 ELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKD-LTKQ-LQQARR 809
Query: 448 KID 450
K+D
Sbjct: 810 KLD 812
>X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac mRNA
for myosin heavy chain light meromyosin region. ).
Length = 635
Score = 66.5 bits (155), Expect = 5e-10
Identities = 129/665 (19%), Positives = 260/665 (39%), Gaps = 55/665 (8%)
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXX 508
D+ R L++++ A + + +L R YE E E K RL+ +KA
Sbjct: 14 DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKARLQGDLSKANSEVAQWRT 73
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
EE K L + L + ++ V+ NA + ++ K +
Sbjct: 74 KYETDAIQRTEELEEAKKKLAQRLQEAEEA-VEAVNAKCS-------SLEKTKHRLQNEI 125
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
E ++ E+ N + K++ N K L + + +E+Q SELE S + +
Sbjct: 126 EDLMVDVERSNAAAAALD-----KKQRNFDKILAEWKQKYEESQ-SELESSQKEARSLST 179
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE-----KTRDCSRLE 683
EL K+K +E L EQ + + E K + ++E
Sbjct: 180 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME 239
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
+ E A +++ L+ Q+ E +++ E E K E + E KR++ V L+
Sbjct: 240 LQSALEEAEASLEHEEGKILRAQL-EFNQIKAEIERKRQEKDEEMEQAKRNHLRVVDSLQ 298
Query: 744 SSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+S +A + + V+ + +E D+ + + D
Sbjct: 299 TSLDAETRSRNEALRVKKK---MEGDLNEME---IQLSHANRMAAEAQKQVKSLQSLLKD 352
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L + + +D K +I+++ + + L+ L + ++ + K + E +E
Sbjct: 353 TQIQLDDAVRANDDLKENIAIV-ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 411
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+Q Q L +K ++ +S L+ ++ ++ V+ + A D A + +
Sbjct: 412 RVQLLHSQNTSLINQKKKMDADLSQLQTEV--EEAVQECRNAEEKAKKAITDAAMMAEEL 469
Query: 924 VDRMSYDAEVEKNKRLMK-TIEELRYKKQD-----LKNTVTKMQKAMEKYTKKDKEFEAK 977
A +E+ K+ M+ TI++L+++ + LK ++QK + + + E EA+
Sbjct: 470 KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 529
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV 1037
+K + + + ++R KEL Q EE K L + ++VDKL +
Sbjct: 530 QKRNAESVKGMRKSERRIKEL----------TYQTEEDRKNLLRLQ---DLVDKLQLKVK 576
Query: 1038 ALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
A ++Q E +N + + + + ++ D+ + ++ K+ AK I G
Sbjct: 577 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE--SQVNKLRAKSRDI----GTK 630
Query: 1098 GANRE 1102
G N E
Sbjct: 631 GLNEE 635
Score = 44.0 bits (99), Expect = 0.003
Identities = 43/212 (20%), Positives = 80/212 (37%), Gaps = 13/212 (6%)
Query: 822 ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS 881
+ ++ ++ LK +L + + L + +C+ E +E E ARL+ +
Sbjct: 4 VGELASGQLGDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKARLQGDLSK 63
Query: 882 LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLM 940
+V+ + + T ++R + + + V + + +EK K RL
Sbjct: 64 ANSEVAQWRTKYETDA-IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQ 122
Query: 941 KTIEELRYKKQDLKNTVTKMQKAM-----------EKYTKKDKEFEAKRKELEDCKAELE 989
IE+L + + K +KY + E E+ +KE EL
Sbjct: 123 NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 182
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
+LK Y+E E ET K +E+ L E
Sbjct: 183 KLKNAYEESLEHLETFKRENKNLQEEISDLTE 214
Score = 42.3 bits (95), Expect = 0.009
Identities = 103/563 (18%), Positives = 214/563 (38%), Gaps = 48/563 (8%)
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
L + +L E V N L S + D++ RE+ + +E + Q +L K
Sbjct: 12 LGDLKRQLEEEVKAKNALAHALQSARHDCDLL-REQYEEETEAKARLQG------DLSKA 64
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR-DCSRLEINIKT-HEK 691
+++ +EAK L Q L E+ E CS LE KT H
Sbjct: 65 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE---KTKHRL 121
Query: 692 TAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ 751
EI++ M+ ++ + + K K+ Y+ + +LESS++
Sbjct: 122 QNEIEDLMV-----DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS 176
Query: 752 LTTQ----KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
L+T+ K+ E + LE+ R + +
Sbjct: 177 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 236
Query: 808 LGENPKLDDSPKRSIS------VISDSEVSQLKERLLSCQQELDDLKERYKE-------- 853
E + + S+ + + E +Q+K + +QE D+ E+ K
Sbjct: 237 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKRQEKDEEMEQAKRNHLRVVDS 296
Query: 854 ----LDDECETCAEYLQERDEQCARLKKEKLSLE---QQVSNLKEQIRTQQPVERQAKFA 906
LD E + E L+ + + L + ++ L + + ++Q+++ Q + + +
Sbjct: 297 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 356
Query: 907 -DVAVNTDEDWANLHSVVVDRMSY-DAEVEKNKRLMKTIEELR-YKKQDLKNTVTKMQKA 963
D AV ++D ++V R + AE+E+ + +++ E R +Q+L T ++Q
Sbjct: 357 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 416
Query: 964 MEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAK 1023
+ T + + +L + E+EE Q + +E+ + E+ K+ ++
Sbjct: 417 HSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 476
Query: 1024 IALEIVDKLSNQKVA-LEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
LE + K Q + L+ +++ + + A V +++ + ++ QK
Sbjct: 477 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV--RELENELEAEQKRNA 534
Query: 1083 MNAKLITICKKRGKTGANRENED 1105
+ K + ++R K + ED
Sbjct: 535 ESVKGMRKSERRIKELTYQTEED 557
Score = 35.9 bits (79), Expect = 0.80
Identities = 85/448 (18%), Positives = 192/448 (42%), Gaps = 36/448 (8%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDI 84
+ L+ K + N IE ++ ++ + K ++ + E K E+ EL
Sbjct: 112 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWKQKYEESQSELESS 170
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
+++ +L + L + + +++ + EN +EI +LT+ L + K I+EL+
Sbjct: 171 QKEARSLSTELFKL---KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 227
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQ 204
+ L E L +++ + + E K + + N+ + +I K
Sbjct: 228 KVRKQLE-------AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKR---- 276
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
+ K+ ++ + + L S+ D+ T +R N+ ++ +++ D E+ E
Sbjct: 277 -QEKDEEMEQAKRNHLRVVDSLQTSL-DAETRSR-NEALRVKKKMEG---DLNEM-EIQL 329
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ--LINNESKKSK 322
S N + L L + AV+ ++K N+ + + L+ E ++ +
Sbjct: 330 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 389
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--IIN-KYQIDLDEILEKYTKVQGDLNE 379
+++ + S + + E TS V + N +IN K ++D D + + T+V+ + E
Sbjct: 390 AVVEQTERS-RKLAEQELIETSERVQLLHSQNTSLINQKKKMDAD-LSQLQTEVEEAVQE 447
Query: 380 CTSELKSVNEKL--ASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEIL 437
C + + + + A++ ++ ++KE + ER+ + D+ + +E ++I
Sbjct: 448 CRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAEQIA 504
Query: 438 TKECLK-LSKLKIDIPRDLDQDLPAHKK 464
K K L KL+ + R+L+ +L A +K
Sbjct: 505 LKGGKKQLQKLEARV-RELENELEAEQK 531
>BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein.
Length = 887
Score = 66.5 bits (155), Expect = 5e-10
Identities = 133/673 (19%), Positives = 283/673 (42%), Gaps = 50/673 (7%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
I + + +L+E E+ + +L + ELK + ++ N L+ + + R + + +
Sbjct: 257 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE----NMNLLSDARSARMYRDELDAL 312
Query: 416 HEISSAVTIDIVKKE-NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
E AV +D ++ E + KE L ++ K +++ ++ +Q L K T+L D L
Sbjct: 313 RE--KAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK--TMLEDQLEG 366
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
S +E+EKE L+L+ + + + +S+ E L
Sbjct: 367 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 426
Query: 535 LYKSKVDENNANLNLI--KILSEEIDALKIA-IAKNEEKMLSLSEKDNKLTELVSTINGL 591
++ + + L+ K L E++ L + + K E + SL++ +L V ++ G
Sbjct: 427 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 486
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
+ ++ N ++++ E +E+ + Q + QN L K D++
Sbjct: 487 ASKILKMEKENQRLSKKVEILENEIVQEKQSL-QNCQNLSK---DLMKEKAQLEKTIETL 542
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+ +LEQ Q R R +I+ + K E +N++ L + I+E
Sbjct: 543 RENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKI---LHESIKETS 597
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDI- 770
+ E + ++ + E K + A ++LE+ ++ L + +L++ +I L+
Sbjct: 598 SKLSKIEFEKRQIKKELEHYKEKGERA-EELENE---LHHLEKENELLQKKITNLKITCE 653
Query: 771 RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEV 830
+ E TF E+ + EN +LD+ + E+
Sbjct: 654 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-ENSQLDEE---------NLEL 703
Query: 831 SQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLK 890
+ E L ++ L+ KEL+ E E + L+ + + K E+L + Q +++
Sbjct: 704 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL--KASFKKTERLEVSYQGLDIE 761
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKK 950
Q R Q+ +E K + + L + ++ + +E+ K K +E+L +
Sbjct: 762 NQ-RLQKTLENSNK------KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 814
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK 1010
+ L+ ++++K ++ K++K ++ E++D LEE + L++E +T ++ +
Sbjct: 815 KSLEQETSQLEKDKKQLEKENKRLR-QQAEIKD--TTLEENNVKIGNLEKENKTLSKEIG 871
Query: 1011 QREEQCKRLKEAK 1023
+E C RLKE K
Sbjct: 872 IYKESCVRLKELK 884
Score = 64.5 bits (150), Expect = 2e-09
Identities = 132/616 (21%), Positives = 262/616 (42%), Gaps = 54/616 (8%)
Query: 41 QSNPIKLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEG-KYQ 96
Q N L D+ + + +L+E + +++ ++ + L DI+ K+ +E K
Sbjct: 290 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 349
Query: 97 N-LILETQT--RDLL------MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEEN 147
N ++LET+T D L ++ LE ENL ++ ++ KKI EL EEN
Sbjct: 350 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 409
Query: 148 DTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE-SENKIGPKNICAQCK 206
TL +++ ES +L E++ + + +E L VNE + +++ + Q
Sbjct: 410 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 469
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSEL---DAGREDCKELCED 262
K ++ L D+ ++ + + R + K+ L++E+ ++C+ L +D
Sbjct: 470 TK--TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 527
Query: 263 FTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
K LE T+ E L EN+E + +K++ + +LN L ++
Sbjct: 528 LMKEKAQLE-----KTI---ETLRENSE---RQIKILEQENEHLNQTVSSLRQRSQISAE 576
Query: 323 DHI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNEC 380
+ D K++ +L TS + +I + K +++ E E+ +++ +L+
Sbjct: 577 ARVKDIEKEN--KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL 634
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
E + + +K+ +L EK A + ER + T+D K E L KE
Sbjct: 635 EKENELLQKKITNLKI-TCEKIEALEQENSELERENR-KLKKTLDSFKNLTFQLESLEKE 692
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLETGTAK 498
+L + +++ R+++ A K+ L + EL +++K E L+ +
Sbjct: 693 NSQLDEENLELRRNVESLKCASMKMAQL---QLENKELESEKEQLKKGLELLKASFKKTE 749
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
+ TLE ++ +++ L EL L + + NL +KI S+ ++
Sbjct: 750 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLE 808
Query: 559 ALKIAIAKNEEKMLSLS------EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQ 612
L+ E++ L EK+NK + I E N++K N + +E +T
Sbjct: 809 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN--LEKENKTL 866
Query: 613 ASEL---ERSCQVIKQ 625
+ E+ + SC +K+
Sbjct: 867 SKEIGIYKESCVRLKE 882
Score = 62.9 bits (146), Expect = 6e-09
Identities = 99/590 (16%), Positives = 247/590 (41%), Gaps = 49/590 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLI------KILSEEIDALKIAIAKNEEKM 571
LEE ++ +EL ++ N+NL+ ++ +E+DAL+ + ++
Sbjct: 264 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK-- 321
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
L + ++ E + I K LK N V+ K +LE + + +L
Sbjct: 322 --LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT----RARSDKLH 375
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
+++ + L + + L+E+N+ L+ ++ + L ++ +
Sbjct: 376 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 435
Query: 692 TAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
T+E+ L ++ E ++ E + LT E L+ D+ +E + +
Sbjct: 436 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS----VEGNASKIL 491
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
++ + + ++ LE++I E+ + T
Sbjct: 492 KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET---------- 541
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-RYKELDDECETCAEYLQERD 869
L ++ +R I ++ + E L + + S +Q E R K+++ E + E ++E
Sbjct: 542 ---LRENSERQIKIL-EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 597
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ ++++ EK +++++ + KE+ + +E + + + + +++
Sbjct: 598 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-- 655
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA--- 986
+A ++N L + +L+ KN +++ ++ ++ D+E R+ +E K
Sbjct: 656 EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 715
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV--ALE---- 1040
++ +L+ KEL+ E E + L+ + K+ + +++ + +D + NQ++ LE
Sbjct: 716 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD-IENQRLQKTLENSNK 774
Query: 1041 --KQIES-LSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+Q+ES L + + N T+ + ++++ + KEN+ L++ ++L
Sbjct: 775 KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 824
Score = 59.7 bits (138), Expect = 6e-08
Identities = 111/580 (19%), Positives = 227/580 (39%), Gaps = 30/580 (5%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + +++ L + + K +DE + + I LSEE D L +
Sbjct: 174 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCG 233
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K TE + L E K+ + +E E + +L Q ++Q EL +++
Sbjct: 234 SPGMKRTE---SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 290
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINI-KTHEKTA 693
+ + DE +L E+ + + + E +R RL +I K +
Sbjct: 291 ENM----NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 346
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ N++++ + +++ + + KL+EL + LK A + D+E R+ +
Sbjct: 347 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK----AKLHDMEMERDMDRKKI 402
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
++L+E + LE + ++ + G E +L +
Sbjct: 403 --EELMEENMT-LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 459
Query: 814 L-----DDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
L + S +++ + + V ++L ++E L ++ + L++E + LQ
Sbjct: 460 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ 519
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
L KEK LE+ + L+E Q + Q + T + +
Sbjct: 520 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEA 577
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA 986
D E E NK L ++I+E K ++ +++K +E Y +K + E EL +
Sbjct: 578 RVKDIEKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 636
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
E E L+++ L CE ++ E + ++ K L+ L+ Q +LEK+ L
Sbjct: 637 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 696
Query: 1047 --SNTPVSNSTMYVATGSAIVQNQQI--TDVMKENQKLKK 1082
N + + + S + Q+ ++ E ++LKK
Sbjct: 697 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 736
Score = 46.8 bits (106), Expect = 4e-04
Identities = 35/140 (25%), Positives = 68/140 (48%), Gaps = 7/140 (5%)
Query: 56 SCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQT-----RDLLMS 110
S K + L+ S ++++ ++L L + ++ LE + Q+L +E QT +L +S
Sbjct: 744 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 803
Query: 111 --QIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV 168
+++ LE EN + ++E L K K+ L+++ + + EN + NL KE
Sbjct: 804 SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 863
Query: 169 DDLKKNNECLTQKCIDLEKL 188
L K + C+ L++L
Sbjct: 864 KTLSKEIGIYKESCVRLKEL 883
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 819 KRSISVISDSEVSQLKERLLSCQ---QELDDLKERYKELD-DECETCAEYLQE---RDEQ 871
K S EV +L LL C Q+ ++ ER + LD D A ++QE E
Sbjct: 107 KNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN 166
Query: 872 CARLKKEK---LSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
L+ + +S E LK + ++ ++ + + ++ + E+ LH +
Sbjct: 167 VFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHA 224
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S A+ MK E ++ +L + K+++ + E E K ++L DCK E
Sbjct: 225 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQ-------ELEEKTEQLLDCKQE 277
Query: 988 LEELKQRYKELDEE 1001
LE+++ K L +E
Sbjct: 278 LEQMEIELKRLQQE 291
>BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for
IMAGE:5563109) protein.
Length = 1374
Score = 66.5 bits (155), Expect = 5e-10
Identities = 114/537 (21%), Positives = 226/537 (42%), Gaps = 50/537 (9%)
Query: 598 LKSLNDVITREKETQASELE----RSCQVIKQNGF-ELDKMKADILMXXXXXXXXXXXXX 652
+K L V +E+E A E E R Q+ +N E++ +++ ++
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 653 XXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK 712
EA+ L + A K++ EE C LE ++ E+ + ++Q+ IQE ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEI---CHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSR---EAVN-QLTTQKDLVEGRIAELES 768
E+E+ +L + K +A +K LE + E N +L +K L+E RIAE +
Sbjct: 951 QLEEEESARQKL----QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
++ E+ + E R E + + K + DS
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDL---------EERLRREEKQRQELEKTRRKLEGDS 1057
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+ L +++ Q ++ +LK + + ++E + ++E Q K+ LE Q+S
Sbjct: 1058 --TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE--KNKR------LM 940
L+E + +++ +A+ + E+ L + + D + A + ++KR L
Sbjct: 1116 LQEDLESERASRNKAE--KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 941 KTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE----ELKQRY 995
KT+ EE + + ++ K +A+E+ ++ ++ + + LE K LE EL
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 996 KEL-----DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
K L D E + + +E Q K + ++ E+ DK++ +V L+ LS +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 1051 VSNSTMYVATGSAIVQNQQITD--VMKENQKLKKMNAKLITICKKRGKTGANRENED 1105
S S+ SA+ Q T + +EN++ ++ KL + ++ E E+
Sbjct: 1294 -SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Score = 53.6 bits (123), Expect = 4e-06
Identities = 110/535 (20%), Positives = 219/535 (40%), Gaps = 40/535 (7%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL V EK + ++L E E + L +K ++ E A T ++ + EL+ LT +
Sbjct: 853 ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET-ELCAEAEELRARLTAKKQ 911
Query: 443 KLSKLKIDIPRDLDQD------LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
+L ++ D+ ++++ L A KK I + E + E ++KL+LE T
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKK---KMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEE 556
+A D + E K L + + + + +E + +L K+ ++
Sbjct: 969 TEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH 1025
Query: 557 ---IDALKIAIAKNEEKMLSLSEKDNKL----TELVSTINGLKEENNSLKSLNDVITREK 609
I L+ + + E++ L + KL T+L I L+ + LK + +E+
Sbjct: 1026 EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM--QLAKKEE 1083
Query: 610 ETQASELERSCQVIKQNGFELDKMK---ADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
E QA+ L R + Q L K++ + I + + L E+
Sbjct: 1084 ELQAA-LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 667 ALKEQCEEKTRDCSRLEINIKT-HEKTAEIQNRMIMRLQK----QIQEDDKLFIEKETKL 721
ALK + E+ T D + + +++ E+ I + + K QIQE + + +L
Sbjct: 1143 ALKTELED-TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 722 NELTNKYEALKRDYDAAVKDLESSR-EAVNQLTTQKDLVEGRIAELESDIRTE---QTAT 777
E + + +K + + A + LE+ R E N++ K L++G+ + E Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEV---KVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V + L ++ + S + +S++ +E L
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL-ESQLQDTQELL 1317
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQ 892
++ L + K+++DE + E L+E +E L+K+ +L QV+++K++
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Score = 53.2 bits (122), Expect = 5e-06
Identities = 99/477 (20%), Positives = 206/477 (43%), Gaps = 62/477 (12%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E+ + EEL K+ + ++ N L ++ L ++ A K L L E+ TE
Sbjct: 846 EMMAKEEELVKVREKQLAAEN-RLTEMETLQSQLMAEK----------LQLQEQLQAETE 894
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
L + L+ + K + I + E + E E CQ ++ E KM+ +I
Sbjct: 895 LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA---EKKKMQQNI------ 945
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCE-EKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E + LE+ + +++ + EK ++L+ ++ + E QN + +
Sbjct: 946 ------------QELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQIILEDQNCKLAK 992
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
+K +++ F T+ E + LK ++A + DLE E + + Q+ +E
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKT 1049
Query: 763 IAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
+LE D ++Q A + E +N L +
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL-----K 1104
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
I + +S++S+L+E L S + + +++ ++L +E E L++ + A ++ +
Sbjct: 1105 KIREL-ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
EQ+V+ LK+ + E +AK + + ++ HS V+ ++ ++E+ KR+
Sbjct: 1164 KREQEVNILKKTL------EEEAKTHEAQI---QEMRQKHSQAVEELA--EQLEQTKRVK 1212
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+E+ KQ L+N ++ ++ + + E KRK++E A+L+EL+ ++ E
Sbjct: 1213 ANLEK---AKQTLENERGELANEVKVLLQGKGDSEHKRKKVE---AQLQELQVKFNE 1263
Score = 46.8 bits (106), Expect = 4e-04
Identities = 76/427 (17%), Positives = 163/427 (38%), Gaps = 23/427 (5%)
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-QLIEKENACNILRIQK---E 413
K Q ++ E+ E+ + + + E + KL L Q+I ++ C + + +K +
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-KITILFDAL 472
RI E ++ +T + +K L ++ K ++ L+ + R+ Q K + + D+
Sbjct: 1000 RIAEFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDST 1058
Query: 473 ITQYELSRTDYEIEKEKLRL--ETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHE 530
+++ +I + K++L + +A + E +++ L E
Sbjct: 1059 DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE 1118
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+L + N A + L EE++ALK + + + E +K + V+ +
Sbjct: 1119 DLES---ERASRNKAEKQK-RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 591 LKEENNSLKSLNDVITREKETQA-SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
EE R+K +QA EL + K+ L+K K +
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL----------EN 1224
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+E K LL+ + + ++ L++ E+ + +LQ ++
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
L + ++K ++LT + AL+ + L+ L+T+ VE
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344
Query: 770 IRTEQTA 776
+ E+ A
Sbjct: 1345 LEEEEEA 1351
Score = 42.7 bits (96), Expect = 0.007
Identities = 98/523 (18%), Positives = 213/523 (40%), Gaps = 44/523 (8%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E + Q+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 98 LILETQTRDLLMSQIKS-LEMENLTKDK-EIKNLTDSLKTKSKKINE-----------LQ 144
L E + + +++ LE E + K +++ +T + K KK+ E L
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLA 991
Query: 145 EENDTLSNLIME---NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+E L + I E N+TE + +K + LK +E + DLE+ + E +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQ------ 1042
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
+ + ++ + +++L I++ K LQ+ L E+ +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-KKEEELQAALARVEEEAAQKNM 1101
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
I+ LE + DL+ + N+ E + + E++ L + L + +++
Sbjct: 1102 ALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 322 -KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + L L+ E T + E+ + ++ +L E LE+ +V+ +L +
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH--SQAVEELAEQLEQTKRVKANLEKA 1218
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
L++ +LA+ L++ + E + A ++ K NE + + T+
Sbjct: 1219 KQTLENERGELANEVKVLLQGKG-------DSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 441 CLKLSKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIE-KEKLRLETGT 496
K++KL++++ L Q K+T F AL +Q + ++ + E ++KL L T
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST-K 1330
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
K V + ++ +LH ++ + K K
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKK 1373
Score = 39.5 bits (88), Expect = 0.065
Identities = 37/180 (20%), Positives = 78/180 (43%), Gaps = 6/180 (3%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N +T+M+ + + + +
Sbjct: 827 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVD 1030
+ + + AE EEL+ R +EL+E C +++ EE+C+ L+ E K + +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 1031 KLSNQKVALEKQIESLSNTPV-SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+L Q E + L V + + + I+ Q + KE + L+ A+ T
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
>AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein.
Length = 983
Score = 66.5 bits (155), Expect = 5e-10
Identities = 116/536 (21%), Positives = 227/536 (42%), Gaps = 43/536 (8%)
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I +L S +I +LQE L + + E L E+ + CL I
Sbjct: 420 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-- 477
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
+E+ + + K Q K +E + + L + L ++ D+ + ++++
Sbjct: 478 ----SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYS--HFHELRVT 531
Query: 246 QSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGEN-NEFETKAVKVMSEIK 303
+ E++ ++D + E+ K + EL E + + + E+E S I+
Sbjct: 532 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 591
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL--MDNIINKYQI 361
N+N + + + +++++ I + KD+L + + E + D+ E + M + +NK
Sbjct: 592 -NMNK-EKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 649
Query: 362 DLDEI-------LEKYTKVQGDLNECTSEL--KSVNEKLASL-NSQLIEKENACNILRIQ 411
+L ++ LE Y K + L + T+E K+ +EKL L N + E+A + ++ Q
Sbjct: 650 ELSQLYKEAQAELEDYRK-RKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 708
Query: 412 KERI-HEISSAVTIDIVKKENELK-----EILT------KECL-KLSKLKIDIPRDLDQD 458
++ +E++ + +KEN + +++T KE K+S LK + + +
Sbjct: 709 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASK-EVE 767
Query: 459 LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
+ +K + A +T + R+ YE + L E + +
Sbjct: 768 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 827
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
++VK E + L KSK E N L + EE+ +K A++ K+ +KD
Sbjct: 828 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMK-RYAESSSKL--EEDKD 884
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
K+ E+ + LKE NSL L+ T + Q+ +LE Q +KQ +L + K
Sbjct: 885 KKINEMSKEVTKLKEALNSLSQLS-YSTSSSKRQSQQLEALQQQVKQLQNQLAECK 939
Score = 62.5 bits (145), Expect = 8e-09
Identities = 116/588 (19%), Positives = 252/588 (42%), Gaps = 55/588 (9%)
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
L KS D N+ + ++ + +++ ++ ++ E K L + E ++ ELV N E
Sbjct: 423 LGKSTTD-NDVRIQQLQEILQDLQK-RLESSEAERKQLQV-ELQSRRAELVCLNNTEISE 479
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
N+S D+ + KETQ+ E +V+ +MK ++
Sbjct: 480 NSS-----DLSQKLKETQSKYEEAMKEVLSVQ----KQMKLGLVSPESMDNYSHFHELRV 530
Query: 655 XDEAKSLLEQNL--ALKE--QCEEKTRDCSRLEIN------IKTH-EKTAEIQNRMIMRL 703
+E ++L+Q+L AL+E + +EK R+ + IK E+ E+++ +
Sbjct: 531 TEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 590
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
+ +E LF + + E+ + LK D E +EA+N++ + +
Sbjct: 591 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 650
Query: 763 IAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
+++L + + E + + +R E+ L + +
Sbjct: 651 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDA-LSEMKSQY 709
Query: 822 ISVISD-SEVSQL----KERLLSCQQELD---DLKERYKELDDECETCAEYLQERDEQCA 873
V+++ +++ QL KE +S + L L+ KE++++ E+L ++ + A
Sbjct: 710 SKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVA 769
Query: 874 RLKK----EKLSLEQQVSNLKEQIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMS 928
+L+K EK ++ + + Q +E + A + ++ +HS VV S
Sbjct: 770 KLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRS 829
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
++V++ K ++T+ L+ K+Q++ + K Q+A E+ + + E+ K ED ++
Sbjct: 830 EVSQVKREKENIQTL--LKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 887
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
E+ + +L E + ++ ++ ++ + + V +L NQ +KQ + +
Sbjct: 888 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV-- 945
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+S M++ VQ Q DV QK+ K +++T+CK + +
Sbjct: 946 --ISVYRMHLLYA---VQGQMDEDV----QKVLK---QILTMCKNQSQ 981
Score = 58.8 bits (136), Expect = 1e-07
Identities = 106/506 (20%), Positives = 219/506 (43%), Gaps = 52/506 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLN--LIKILSEEIDALKIAIAKNEEKMLSL---SEKD 578
E++S EL L +++ EN+++L+ L + S+ +A+K ++ ++ L L D
Sbjct: 461 ELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD 520
Query: 579 N-----KLTELVSTINGLKEE-NNSLKSL--NDVITREKETQASELERSCQVIKQNGFEL 630
N +L IN LK++ N+L+ N RE E + E E+ VIK E
Sbjct: 521 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT-VIKPPVEEY 579
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKS-LLEQNLALKEQCEEKTRDCSRLEINIKTH 689
++MK+ EA+ +++ LK Q ++ D +
Sbjct: 580 EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEA--------- 630
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREA 748
E E NRMI L KQ+ E +L+ E + +L + Y K D + + ++ E
Sbjct: 631 EDMKEAMNRMIDELNKQVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHKAEHEK 686
Query: 749 VNQLT-TQKDLVEGRIAELESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ QLT + E ++E++S + E T T
Sbjct: 687 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 746
Query: 805 NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL---KERYKE----LDDE 857
+++ E K+ + + S + EV++L+++LL + + D + Y++ L+ E
Sbjct: 747 AKEMEE--KISNLKEHLAS--KEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE 802
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNL---KEQIRTQQPVERQA--KFADVAVNT 912
A L+E ++ ++ E + + +VS + KE I+T + Q +
Sbjct: 803 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA 862
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ A + S E +K+K++ + +E+ K+ L N+++++ + ++ +
Sbjct: 863 QEELAEMKRYA--ESSSKLEEDKDKKINEMSKEVTKLKEAL-NSLSQLSYSTSSSKRQSQ 919
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL 998
+ EA +++++ + +L E K++++E+
Sbjct: 920 QLEALQQQVKQLQNQLAECKKQHQEV 945
Score = 41.5 bits (93), Expect = 0.016
Identities = 66/421 (15%), Positives = 192/421 (45%), Gaps = 28/421 (6%)
Query: 59 MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
+ SL +S+ + ++++++L L D++++ + E + + L +E Q+R + + + E+
Sbjct: 419 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEIS 478
Query: 119 NLTKD--KEIKNLTDSLKTKSKKINELQEENDT--LSNLIMENVTESDNLN---KEVDDL 171
+ D +++K + K++ +Q++ +S M+N + L +E++ L
Sbjct: 479 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVL 538
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
K++ + ++ ++ V E E K+ + K + + Y + + +N+
Sbjct: 539 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKE-- 596
Query: 232 DSNTSTRYNKICTLQSELDAGREDCK-ELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
+ + K Q E+ ++ K ++ ++ + ++ M +L++++ E ++
Sbjct: 597 ---KAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ 653
Query: 291 FETKAVKVMSEIKR--NLNSLSEQLIN---NESKKSKDHIDRYK-DSLLAVLDAEFGTTS 344
+A + + ++ +L ++ + I+ +E ++ R K + L+ + +++
Sbjct: 654 LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 713
Query: 345 LDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS-------LNS 396
++ ++ + + + + + E L+ T ++ E ++ ++ E LAS L
Sbjct: 714 NELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEK 773
Query: 397 QLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLD 456
QL+E++ A + + ++ S++ ++ ++LKE + KE K+ + I ++
Sbjct: 774 QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVS 832
Query: 457 Q 457
Q
Sbjct: 833 Q 833
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/196 (23%), Positives = 92/196 (46%), Gaps = 12/196 (6%)
Query: 75 EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
EKL L + + S L K + + E + + QI+S E+ + ++KE N+ LK
Sbjct: 793 EKLQSSL---ESEVSVLASKLKESVKEKEKVHSEVVQIRS-EVSQVKREKE--NIQTLLK 846
Query: 135 TKSKKINELQEENDTLSNLIMENVTESDNLNK-EVDDLKKNNECLTQKCIDLEKLVNE-S 192
+K +++NEL ++ + E +++ +K E D KK NE ++++ L++ +N S
Sbjct: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINE-MSKEVTKLKEALNSLS 905
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ + Q + E L Q + N L++ + + + R + + +Q ++D
Sbjct: 906 QLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDED 964
Query: 253 REDCKELCEDFTSIKN 268
+ K L + T KN
Sbjct: 965 VQ--KVLKQILTMCKN 978
>AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment
epithelial cell protein protein.
Length = 980
Score = 66.5 bits (155), Expect = 5e-10
Identities = 116/536 (21%), Positives = 227/536 (42%), Gaps = 43/536 (8%)
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I +L S +I +LQE L + + E L E+ + CL I
Sbjct: 417 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-- 474
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
+E+ + + K Q K +E + + L + L ++ D+ + ++++
Sbjct: 475 ----SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYS--HFHELRVT 528
Query: 246 QSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGEN-NEFETKAVKVMSEIK 303
+ E++ ++D + E+ K + EL E + + + E+E S I+
Sbjct: 529 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 588
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL--MDNIINKYQI 361
N+N + + + +++++ I + KD+L + + E + D+ E + M + +NK
Sbjct: 589 -NMNK-EKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 646
Query: 362 DLDEI-------LEKYTKVQGDLNECTSEL--KSVNEKLASL-NSQLIEKENACNILRIQ 411
+L ++ LE Y K + L + T+E K+ +EKL L N + E+A + ++ Q
Sbjct: 647 ELSQLYKEAQAELEDYRK-RKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 705
Query: 412 KERI-HEISSAVTIDIVKKENELK-----EILT------KECL-KLSKLKIDIPRDLDQD 458
++ +E++ + +KEN + +++T KE K+S LK + + +
Sbjct: 706 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASK-EVE 764
Query: 459 LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
+ +K + A +T + R+ YE + L E + +
Sbjct: 765 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 824
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
++VK E + L KSK E N L + EE+ +K A++ K+ +KD
Sbjct: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMK-RYAESSSKL--EEDKD 881
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
K+ E+ + LKE NSL L+ T + Q+ +LE Q +KQ +L + K
Sbjct: 882 KKINEMSKEVTKLKEALNSLSQLS-YSTSSSKRQSQQLEALQQQVKQLQNQLAECK 936
Score = 62.5 bits (145), Expect = 8e-09
Identities = 116/588 (19%), Positives = 252/588 (42%), Gaps = 55/588 (9%)
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
L KS D N+ + ++ + +++ ++ ++ E K L + E ++ ELV N E
Sbjct: 420 LGKSTTD-NDVRIQQLQEILQDLQK-RLESSEAERKQLQV-ELQSRRAELVCLNNTEISE 476
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
N+S D+ + KETQ+ E +V+ +MK ++
Sbjct: 477 NSS-----DLSQKLKETQSKYEEAMKEVLSVQ----KQMKLGLVSPESMDNYSHFHELRV 527
Query: 655 XDEAKSLLEQNL--ALKE--QCEEKTRDCSRLEIN------IKTH-EKTAEIQNRMIMRL 703
+E ++L+Q+L AL+E + +EK R+ + IK E+ E+++ +
Sbjct: 528 TEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 587
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
+ +E LF + + E+ + LK D E +EA+N++ + +
Sbjct: 588 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 647
Query: 763 IAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
+++L + + E + + +R E+ L + +
Sbjct: 648 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDA-LSEMKSQY 706
Query: 822 ISVISD-SEVSQL----KERLLSCQQELD---DLKERYKELDDECETCAEYLQERDEQCA 873
V+++ +++ QL KE +S + L L+ KE++++ E+L ++ + A
Sbjct: 707 SKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVA 766
Query: 874 RLKK----EKLSLEQQVSNLKEQIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMS 928
+L+K EK ++ + + Q +E + A + ++ +HS VV S
Sbjct: 767 KLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRS 826
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
++V++ K ++T+ L+ K+Q++ + K Q+A E+ + + E+ K ED ++
Sbjct: 827 EVSQVKREKENIQTL--LKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 884
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
E+ + +L E + ++ ++ ++ + + V +L NQ +KQ + +
Sbjct: 885 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV-- 942
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+S M++ VQ Q DV QK+ K +++T+CK + +
Sbjct: 943 --ISVYRMHLLYA---VQGQMDEDV----QKVLK---QILTMCKNQSQ 978
Score = 58.8 bits (136), Expect = 1e-07
Identities = 106/506 (20%), Positives = 219/506 (43%), Gaps = 52/506 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLN--LIKILSEEIDALKIAIAKNEEKMLSL---SEKD 578
E++S EL L +++ EN+++L+ L + S+ +A+K ++ ++ L L D
Sbjct: 458 ELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD 517
Query: 579 N-----KLTELVSTINGLKEE-NNSLKSL--NDVITREKETQASELERSCQVIKQNGFEL 630
N +L IN LK++ N+L+ N RE E + E E+ VIK E
Sbjct: 518 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT-VIKPPVEEY 576
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKS-LLEQNLALKEQCEEKTRDCSRLEINIKTH 689
++MK+ EA+ +++ LK Q ++ D +
Sbjct: 577 EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEA--------- 627
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREA 748
E E NRMI L KQ+ E +L+ E + +L + Y K D + + ++ E
Sbjct: 628 EDMKEAMNRMIDELNKQVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHKAEHEK 683
Query: 749 VNQLT-TQKDLVEGRIAELESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ QLT + E ++E++S + E T T
Sbjct: 684 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 743
Query: 805 NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL---KERYKE----LDDE 857
+++ E K+ + + S + EV++L+++LL + + D + Y++ L+ E
Sbjct: 744 AKEMEE--KISNLKEHLAS--KEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE 799
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNL---KEQIRTQQPVERQA--KFADVAVNT 912
A L+E ++ ++ E + + +VS + KE I+T + Q +
Sbjct: 800 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA 859
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ A + S E +K+K++ + +E+ K+ L N+++++ + ++ +
Sbjct: 860 QEELAEMKRYA--ESSSKLEEDKDKKINEMSKEVTKLKEAL-NSLSQLSYSTSSSKRQSQ 916
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL 998
+ EA +++++ + +L E K++++E+
Sbjct: 917 QLEALQQQVKQLQNQLAECKKQHQEV 942
Score = 41.5 bits (93), Expect = 0.016
Identities = 66/421 (15%), Positives = 192/421 (45%), Gaps = 28/421 (6%)
Query: 59 MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
+ SL +S+ + ++++++L L D++++ + E + + L +E Q+R + + + E+
Sbjct: 416 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEIS 475
Query: 119 NLTKD--KEIKNLTDSLKTKSKKINELQEENDT--LSNLIMENVTESDNLN---KEVDDL 171
+ D +++K + K++ +Q++ +S M+N + L +E++ L
Sbjct: 476 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVL 535
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
K++ + ++ ++ V E E K+ + K + + Y + + +N+
Sbjct: 536 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKE-- 593
Query: 232 DSNTSTRYNKICTLQSELDAGREDCK-ELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
+ + K Q E+ ++ K ++ ++ + ++ M +L++++ E ++
Sbjct: 594 ---KAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ 650
Query: 291 FETKAVKVMSEIKR--NLNSLSEQLIN---NESKKSKDHIDRYK-DSLLAVLDAEFGTTS 344
+A + + ++ +L ++ + I+ +E ++ R K + L+ + +++
Sbjct: 651 LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 710
Query: 345 LDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS-------LNS 396
++ ++ + + + + + E L+ T ++ E ++ ++ E LAS L
Sbjct: 711 NELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEK 770
Query: 397 QLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLD 456
QL+E++ A + + ++ S++ ++ ++LKE + KE K+ + I ++
Sbjct: 771 QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVS 829
Query: 457 Q 457
Q
Sbjct: 830 Q 830
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/196 (23%), Positives = 92/196 (46%), Gaps = 12/196 (6%)
Query: 75 EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
EKL L + + S L K + + E + + QI+S E+ + ++KE N+ LK
Sbjct: 790 EKLQSSL---ESEVSVLASKLKESVKEKEKVHSEVVQIRS-EVSQVKREKE--NIQTLLK 843
Query: 135 TKSKKINELQEENDTLSNLIMENVTESDNLNK-EVDDLKKNNECLTQKCIDLEKLVNE-S 192
+K +++NEL ++ + E +++ +K E D KK NE ++++ L++ +N S
Sbjct: 844 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINE-MSKEVTKLKEALNSLS 902
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ + Q + E L Q + N L++ + + + R + + +Q ++D
Sbjct: 903 QLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDED 961
Query: 253 REDCKELCEDFTSIKN 268
+ K L + T KN
Sbjct: 962 VQ--KVLKQILTMCKN 975
>AB111886-1|BAC98374.1| 1571|Homo sapiens KIAA2034 protein protein.
Length = 1571
Score = 66.1 bits (154), Expect = 7e-10
Identities = 190/1037 (18%), Positives = 398/1037 (38%), Gaps = 74/1037 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS----LEMEN 119
+E S ++ + ++L + +++ A EG Q L LE T + M + + LE +N
Sbjct: 528 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 587
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIME---NVTE-SDNLNKE------VD 169
KE K L D L S + E +E+ +L+ L ++ + + D L KE ++
Sbjct: 588 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 647
Query: 170 DLKKN----NECLTQKCIDLEKLVNESENKIGPKNICAQCKL---------KENLIQSLH 216
LK+ + L ++ ++ ++ E ++G K Q L + L++SL
Sbjct: 648 KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR 707
Query: 217 IGYDNTLSKLNRSISDSNTSTRYNKICT-LQSELDAGREDCKELCEDFTSIKNHLELHEP 275
S+ T+ K L EL+A R + ++ D T+ + L
Sbjct: 708 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL-DSTNAQQELRSKRE 766
Query: 276 NMTMDLDEKLGENNEFETKAVKVMSEIK-RNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
+L + L E AV+ + + + L L+EQL ++++ K ++ + +L A
Sbjct: 767 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL--EQARRGKGAWEKTRLALEA 824
Query: 335 -VLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
V + +SL + + ++ L E+ + + E +L+ +L +
Sbjct: 825 EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELEN 884
Query: 394 LNSQLIEKENACNILRIQKERIH-EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIP 452
++ L E E+ +R+ KE E +++++E K L + +
Sbjct: 885 VSGALNEAES--KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 942
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG--TAKAVXXXXXXXXXX 510
L+++ A ++ + Q +LS E+E LE G +
Sbjct: 943 EQLEEEAAARERAGR--ELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1000
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIK-------ILSEEIDALKIA 563
+T++ + L +EL + L K +L+EE A+ A
Sbjct: 1001 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1060
Query: 564 IAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS--------- 614
+ + E E++ + L + +E L+ N + E E S
Sbjct: 1061 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSV 1120
Query: 615 -ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC- 672
ELER+C+V +Q +L ++ K+ E++L +++
Sbjct: 1121 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1180
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK 732
EE+ R ++ + + Q + + +K+++ + L K + K EA+K
Sbjct: 1181 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE--LEELKAQMASAGQGKEEAVK 1238
Query: 733 --RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
R A +K+L RE V + T ++ + + E E ++ + +
Sbjct: 1239 QLRKMQAQMKELW--RE-VEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1295
Query: 791 XXXXXXXXXTFGDE--NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLK 848
DE N +L + L++ KR + + + QL+E L Q + L
Sbjct: 1296 RRQAQQDRDEMADEVANGNLSKAAILEE--KRQL----EGRLGQLEEELEEEQSNSELLN 1349
Query: 849 ERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADV 908
+RY++L + E+ L A+ + + LE+Q+ L+ ++ + R +
Sbjct: 1350 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1409
Query: 909 AVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYT 968
A + + + + +R K ++E+ + ++ + +++ +EK
Sbjct: 1410 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1469
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ K+ + + +E E+ + + ++R + E+ AE + RE R + + L
Sbjct: 1470 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM-NREVTTLRNRLRRGPLTF 1528
Query: 1029 VDKLSNQKVALEKQIES 1045
+ Q LE+ + S
Sbjct: 1529 TTRTVRQVFRLEEGVAS 1545
Score = 64.9 bits (151), Expect = 2e-09
Identities = 130/748 (17%), Positives = 284/748 (37%), Gaps = 43/748 (5%)
Query: 362 DLDEILEKYTKVQGDLNECT----SELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
+L+ ++ + G+ EC+ +E K + + + L + L +E A L+++K
Sbjct: 512 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 571
Query: 418 ISSAVTIDIVKKENELKEILTKECL---KLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
D++ E++ ++ + L +L++ + ++ + + K+ + ++A I
Sbjct: 572 KMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE-EEKVKSLNKLRLKYEATIA 630
Query: 475 QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTK 534
E R E EK + LE + + EE ++ EEL
Sbjct: 631 DME-DRLRKE-EKGRQELEK-LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQA 687
Query: 535 LYKSKVDENNANLNLIKIL----------SEEIDALKIAIAKNEEKMLSLSEKDNKLT-E 583
DE A L+K L E++++ ++A K E++ L E+ L E
Sbjct: 688 ALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 747
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASEL---ERSCQVIKQ-NGFELDKMKADILM 639
L T++ + +T K+T E E + Q ++Q +G L ++ +
Sbjct: 748 LEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQ 807
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
E L + +L+ +E + RLE+ ++ + A R
Sbjct: 808 ARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA 867
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
+++Q LNE +K L ++ + L ++E + + T K +
Sbjct: 868 RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL 927
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPK 819
R+ +E++ + + + + + +
Sbjct: 928 GSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEAR 987
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
R + E L +RL + +D L+ + L E + L+++ + + L+K++
Sbjct: 988 RRAA----REAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQ 1043
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
+Q ++ +E+ + VE + + + +L + + E+E+ R
Sbjct: 1044 RKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA 1101
Query: 940 MKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
++ +E L K D+ +V ++++A + + A+ ELED E+ K R +
Sbjct: 1102 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1161
Query: 999 DEECETCAEY-LKQREEQ--------CKRLKEAKIALEIVDKLSNQKVALEKQIE-SLSN 1048
+ +T E L+ R+E K+L++A++ + K VA K++E L
Sbjct: 1162 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1221
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKE 1076
++ A+ Q +++ MKE
Sbjct: 1222 LKAQMASAGQGKEEAVKQLRKMQAQMKE 1249
Score = 58.0 bits (134), Expect = 2e-07
Identities = 76/369 (20%), Positives = 157/369 (42%), Gaps = 28/369 (7%)
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE--TKLNELTNKYEALKRDYDAAVK 740
E+ ++ + E+Q R+ +++ + ++L E E + E + A K++ + V
Sbjct: 459 ELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVS 518
Query: 741 DLES----SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
+LE+ E Q+ T+K ++ I ELE+ + E+ A
Sbjct: 519 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 578
Query: 797 XXXTFGDENRDLGENPK-LDDSPKRSISVISDSE--VSQLKERLLSCQQELDDLKERYKE 853
D+N L + K L+D S ++ E V L + L + + D+++R ++
Sbjct: 579 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 638
Query: 854 LDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF-------- 905
+ + + + D + + L+++ + +Q+ L+ Q+ ++ E QA
Sbjct: 639 EEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE-ELQAALARAEDEGG 697
Query: 906 --ADVAVNTDEDWANLHSVVVDRMSYD-AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQK 962
A + + E A L D S A + K+ EEL + +L++T+
Sbjct: 698 ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA 757
Query: 963 AMEKYTKKDKEFEAKRKELED----CKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
E +K+++E +K LE+ +A ++EL+QR+ + E AE L+Q
Sbjct: 758 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE---LAEQLEQARRGKGA 814
Query: 1019 LKEAKIALE 1027
++ ++ALE
Sbjct: 815 WEKTRLALE 823
Score = 44.4 bits (100), Expect = 0.002
Identities = 87/450 (19%), Positives = 177/450 (39%), Gaps = 27/450 (6%)
Query: 553 LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGL--KEENNSLKSLNDVITREKE 610
L+E++ A A+ EE L+ + +L +VS + +EE S + + ++
Sbjct: 485 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 544
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX-DEAKSLLEQNLA-- 667
Q E + + +L+K+ + M + + LLE LA
Sbjct: 545 IQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEF 604
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ EE+ + S ++ +K A++++R+ + +K QE +KL + + +EL +
Sbjct: 605 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRL-RKEEKGRQELEKLKRRLDGESSELQEQ 663
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
++ + L E + + + G A+L +R Q A
Sbjct: 664 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 723
Query: 788 XXXXXXXXXXXXTFGDENRDL-GENPKLDDSPKRSISVIS--DSEVSQLKERLLS----C 840
G+E L GE DS + S + EV++LK+ L
Sbjct: 724 RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH 783
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
+ + +L++R+ + E AE L++ +K +L+LE +VS L+ ++ + Q
Sbjct: 784 EAAVQELRQRHGQALGEL---AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTAR 840
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKM 960
++ + + L V + D E + + E+L+ + +L+N +
Sbjct: 841 QEGEQRRRRLE-------LQLQEVQGRAGDGE----RARAEAAEKLQRAQAELENVSGAL 889
Query: 961 QKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+A K + KE + +L D + L+E
Sbjct: 890 NEAESKTIRLSKELSSTEAQLHDAQELLQE 919
Score = 42.3 bits (95), Expect = 0.009
Identities = 181/1002 (18%), Positives = 380/1002 (37%), Gaps = 84/1002 (8%)
Query: 81 LFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKI 140
L + Q L+ + Q L + + ++ L+ ++E L + L+ +++
Sbjct: 437 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 496
Query: 141 NELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKN 200
E +E L+ E L V + EC Q + ++L +
Sbjct: 497 AEAEETRGRLAARKQELELVVSELEARVGE---EEECSRQMQTEKKRLQQHIQE------ 547
Query: 201 ICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSEL--DAGREDCKE 258
+ A + +E Q L + T +K+ + D N + + +L D E +
Sbjct: 548 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 607
Query: 259 LCEDFTSIK--NHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
E+ +K N L L D++++L + + + K+ + + L EQ++
Sbjct: 608 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ 667
Query: 317 ESKKS--KDHIDRYKDSLLAVLDA--EFGTTSLDVFEILMDN--IINKYQIDLDEILEKY 370
+ + + + R ++ L A L + G + + L + + + Q DL+
Sbjct: 668 QQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVAR 727
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER-IHEISSAVTIDIVKK 429
TK + + EL+++ +L ++ NA LR ++E+ + E+ + +
Sbjct: 728 TKAEKQRRDLGEELEALRGEL----EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH 783
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTD---YE 484
E ++E+ + L +L + + + A +K + +A +++ ELS E
Sbjct: 784 EAAVQELRQRHGQALGELAEQLEQ-ARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 842
Query: 485 IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN 544
E+ + RLE + V + L+ A E++++ L N
Sbjct: 843 GEQRRRRLEL-QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL----------NE 891
Query: 545 ANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
A I+ LS+E+ + + + +E L E+ L S + ++ E L+
Sbjct: 892 AESKTIR-LSKELSSTEAQLHDAQEL---LQEETRAKLALGSRVRAMEAEAAGLRE---- 943
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+ E +A+ ER+ + ++ +L + + EA++L ++
Sbjct: 944 ---QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1000
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET---KL 721
E + R RL+ + E Q +++ L+K+ ++ D+L E++ +
Sbjct: 1001 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1060
Query: 722 NELTNKYEALKRDYDA----AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E + EA R+ +A + LE +EA +L Q + + L S + + +
Sbjct: 1061 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS-KDDVGKS 1119
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V T ++ E+ KL + ++V + ER
Sbjct: 1120 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL----RLEVTV---QALKTQHERD 1172
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT-- 895
L + E + ER ++L + E +Q + LE ++ LK Q+ +
Sbjct: 1173 LQGRDEAGE--ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1230
Query: 896 QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEE--LRYKKQDL 953
Q E + + E W + R ++ ++++ +K +E LR +++
Sbjct: 1231 QGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELA 1290
Query: 954 KNTVTKMQKAMEKYTKKDKEFE---AKRKELEDCKAELE-ELKQRYKELDEECETCAEYL 1009
+ + Q ++ D+ +K LE+ K +LE L Q +EL+EE ++ +E L
Sbjct: 1291 ASDRARRQAQQDRDEMADEVANGNLSKAAILEE-KRQLEGRLGQLEEELEEE-QSNSELL 1348
Query: 1010 KQREE----QCKRL-KEAKIALEIVDKLSNQKVALEKQIESL 1046
R Q + L E K + + LE+QI+ L
Sbjct: 1349 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1390
>M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy chain
protein.
Length = 1337
Score = 65.7 bits (153), Expect = 9e-10
Identities = 112/519 (21%), Positives = 220/519 (42%), Gaps = 50/519 (9%)
Query: 598 LKSLNDVITREKETQASELE----RSCQVIKQNGF-ELDKMKADILMXXXXXXXXXXXXX 652
+K L V +E+E A E E R Q+ +N E++ +++ ++
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 653 XXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK 712
EA+ L + A K++ EE C LE ++ E+ + ++Q+ IQE ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEI---CHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSR---EAVN-QLTTQKDLVEGRIAELES 768
E+E+ +L + K +A +K LE + E N +L +K L+E RIAE +
Sbjct: 951 QLEEEESARQKL----QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
++ E+ + E R E + + K + DS
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDL---------EERLRREEKQRQELEKTRRKLEGDS 1057
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+ L +++ Q ++ +LK + + ++E + ++E Q K+ LE Q+S
Sbjct: 1058 --TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE--KNKR------LM 940
L+E + +++ +A+ + E+ L + + D + A + ++KR L
Sbjct: 1116 LQEDLESERASRNKAE--KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 941 KTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE----ELKQRY 995
KT+ EE + + ++ K +A+E+ ++ ++ + + LE K LE EL
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 996 KEL-----DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTP 1050
K L D E + + +E Q K + ++ E+ DK++ +V L+ LS +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 1051 VSNSTMYVATGSAIVQNQQITD--VMKENQKLKKMNAKL 1087
S S+ SA+ Q T + +EN++ ++ KL
Sbjct: 1294 -SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Score = 53.2 bits (122), Expect = 5e-06
Identities = 99/477 (20%), Positives = 206/477 (43%), Gaps = 62/477 (12%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E+ + EEL K+ + ++ N L ++ L ++ A K L L E+ TE
Sbjct: 846 EMMAKEEELVKVREKQLAAEN-RLTEMETLQSQLMAEK----------LQLQEQLQAETE 894
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
L + L+ + K + I + E + E E CQ ++ E KM+ +I
Sbjct: 895 LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA---EKKKMQQNI------ 945
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCE-EKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E + LE+ + +++ + EK ++L+ ++ + E QN + +
Sbjct: 946 ------------QELEEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQIILEDQNCKLAK 992
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
+K +++ F T+ E + LK ++A + DLE E + + Q+ +E
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKT 1049
Query: 763 IAELESDIR--TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKR 820
+LE D ++Q A + E +N L +
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL-----K 1104
Query: 821 SISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKL 880
I + +S++S+L+E L S + + +++ ++L +E E L++ + A ++ +
Sbjct: 1105 KIREL-ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
EQ+V+ LK+ + E +AK + + ++ HS V+ ++ ++E+ KR+
Sbjct: 1164 KREQEVNILKKTL------EEEAKTHEAQI---QEMRQKHSQAVEELA--EQLEQTKRVK 1212
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+E+ KQ L+N ++ ++ + + E KRK++E A+L+EL+ ++ E
Sbjct: 1213 ANLEK---AKQTLENERGELANEVKVLLQGKGDSEHKRKKVE---AQLQELQVKFNE 1263
Score = 44.8 bits (101), Expect = 0.002
Identities = 74/411 (18%), Positives = 159/411 (38%), Gaps = 23/411 (5%)
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS-QLIEKENACNILRIQK---E 413
K Q ++ E+ E+ + + + E + KL L Q+I ++ C + + +K +
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK-KITILFDAL 472
RI E ++ +T + +K L ++ K ++ L+ + R+ Q K + + D+
Sbjct: 1000 RIAEFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDST 1058
Query: 473 ITQYELSRTDYEIEKEKLRL--ETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHE 530
+++ +I + K++L + +A + E +++ L E
Sbjct: 1059 DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE 1118
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
+L + N A + L EE++ALK + + + E +K + V+ +
Sbjct: 1119 DLES---ERASRNKAEKQK-RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 591 LKEENNSLKSLNDVITREKETQA-SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
EE R+K +QA EL + K+ L+K K +
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL----------EN 1224
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+E K LL+ + + ++ L++ E+ + +LQ ++
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVE 760
L + ++K ++LT + AL+ + L+ L+T+ VE
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Score = 40.3 bits (90), Expect = 0.037
Identities = 92/478 (19%), Positives = 200/478 (41%), Gaps = 43/478 (8%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+++Q KLQ + ++C +E + K ++L D++ + E + Q+
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 98 LILETQTRDLLMSQIKS-LEMENLTKDK-EIKNLTDSLKTKSKKINE-----------LQ 144
L E + + +++ LE E + K +++ +T + K KK+ E L
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT--EAKLKKLEEEQIILEDQNCKLA 991
Query: 145 EENDTLSNLIME---NVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNI 201
+E L + I E N+TE + +K + LK +E + DLE+ + E +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLEERLRREEKQ------ 1042
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
+ + ++ + +++L I++ K LQ+ L E+ +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA-KKEEELQAALARVEEEAAQKNM 1101
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
I+ LE + DL+ + N+ E + + E++ L + L + +++
Sbjct: 1102 ALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 322 -KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + L L+ E T + E+ + ++ +L E LE+ +V+ +L +
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH--SQAVEELAEQLEQTKRVKANLEKA 1218
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
L++ +LA+ L++ + E + A ++ K NE + + T+
Sbjct: 1219 KQTLENERGELANEVKVLLQGKG-------DSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 441 CLKLSKLKIDIPRD---LDQDLPAHKKITILFDALITQYELSRTDYEIE-KEKLRLET 494
K++KL++++ L Q K+T F AL +Q + ++ + E ++KL L T
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST 1329
Score = 39.5 bits (88), Expect = 0.065
Identities = 37/180 (20%), Positives = 78/180 (43%), Gaps = 6/180 (3%)
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
W L + V + + E+ + + ++R K+ +N +T+M+ + + + +
Sbjct: 827 WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886
Query: 976 AKRKELEDCKAELEELKQRY----KELDEECETCAEYLKQREEQCKRLK-EAKIALEIVD 1030
+ + + AE EEL+ R +EL+E C +++ EE+C+ L+ E K + +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 1031 KLSNQKVALEKQIESLSNTPV-SNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
+L Q E + L V + + + I+ Q + KE + L+ A+ T
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
>AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.19 protein.
Length = 820
Score = 65.7 bits (153), Expect = 9e-10
Identities = 165/835 (19%), Positives = 334/835 (40%), Gaps = 76/835 (9%)
Query: 274 EPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNS--LSEQLINNESKKSKDHIDRYKDS 331
E ++ M + + L +N + + + S+I ++ L+E+L ++K K I + +DS
Sbjct: 27 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQ-IKQTEDS 85
Query: 332 LLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNECTSELKSVNEK 390
L + D + ++ +I N + K ++ L + + +L + + ++K
Sbjct: 86 LASERD-RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 144
Query: 391 LASLNSQLI-EKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI 449
+ L QL E N +I +++ + A+ ++ K + + E K+ ++ + I
Sbjct: 145 IRLLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 200
Query: 450 DIPRDLDQDLPAHKKI--TILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXX 507
++ D+ L +++ T L + EL+ E L E KA
Sbjct: 201 ---QEKDEKLKTVEELLETGLIQVATKEEELNAI--RTENSSLTKEVQDLKAKQNDQVSF 255
Query: 508 XXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN 567
+ E ++KS+ EEL + KV ++ L +EI ALK I
Sbjct: 256 ASLVEELKKVIHEKDGKIKSV-EELLEAELLKVANKEKT---VQDLKQEIKALKEEIGNV 311
Query: 568 E-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQN 626
+ EK LS +K+ EL + + G +E+ N++K+ + EKE + + Q +++
Sbjct: 312 QLEKAQQLSIT-SKVQELQNLLKGKEEQMNTMKA----VLEEKEKDLANTGKWLQDLQE- 365
Query: 627 GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI 686
E + +KA + A E + LKE K + RLE +
Sbjct: 366 --ENESLKAHV-------QEVAQHNLKEASSASQFEELEIVLKE----KENELKRLEAML 412
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
K E+ +++ ++ +L + +Q+++KLF + +L + + + ++ +K +
Sbjct: 413 K--ERESDLSSKT--QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 468
Query: 747 EAV----NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+ + N+L + KD VE + + +D+R + +
Sbjct: 469 KEISGLWNELDSLKDAVEHQ-RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQ 527
Query: 803 DENRDLGENPKLDDS-PKRSI-SVISDSE-VSQLKERLLSCQQELDDLKERYKELDDECE 859
E +L L PK S+ S +S E + +++ C E K L+ + +
Sbjct: 528 VEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-SEEVKVLEHKLK 586
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL 919
E +C + K E + L+ + + E + K V DE +
Sbjct: 587 EADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQE---ENKWK-----VKVDESHKTI 638
Query: 920 HSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE---- 975
+ S + E+E+ + K IE LR +++ L+ + K + Y + +E +
Sbjct: 639 KQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLT 698
Query: 976 AKRKELEDCKAEL----EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD- 1030
+K+L+D +E EEL +L+E +R++ L +A+ +LE++
Sbjct: 699 ELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 758
Query: 1031 ---KLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
K + +E S TM V+ + Q QQ+ + NQ+L K
Sbjct: 759 KIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV--NQQLTK 811
Score = 59.7 bits (138), Expect = 6e-08
Identities = 171/837 (20%), Positives = 334/837 (39%), Gaps = 67/837 (8%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM 117
++ Q ++ +N K E L ++ DI EQ AL+ + Q + + + L
Sbjct: 12 RLMQLMESEQKRVN-KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHK 70
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSN---LIMENVTESDNLNKE----VDD 170
KDK+IK DSL ++ ++ +EE + N L+ V + L E +
Sbjct: 71 VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 130
Query: 171 LKKNNECLTQKCIDL----EKLVNESENKIGP-KNICAQCKLKENLIQSLHIGYDNTLSK 225
L+K + + K + E+L +E NK+ K + Q K ++ +Q L +K
Sbjct: 131 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 190
Query: 226 LNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKL 285
+ + K+ T++ L+ G E+ +I+ DL K
Sbjct: 191 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE-NSSLTKEVQDLKAKQ 249
Query: 286 GENNEFET---KAVKVMSEIKRNLNSLSEQLINNESKK--SKDHIDRYKDSLLAVLDAEF 340
+ F + + KV+ E + S+ E+L+ E K +K+ + + L E
Sbjct: 250 NDQVSFASLVEELKKVIHEKDGKIKSV-EELLEAELLKVANKEKTVQDLKQEIKALKEEI 308
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEIL----EKYTKVQGDLNECTSELKSVNEKLASLNS 396
G L+ + L +I +K Q +L +L E+ ++ L E +L + + L L
Sbjct: 309 GNVQLEKAQQL--SITSKVQ-ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQE 365
Query: 397 QLIEKENACNILRIQKERIHEISSA-----VTIDIVKKENELKEILTKECLKLSKLKIDI 451
+ + ++ + + + E SSA + I + +KENELK + + LK + +
Sbjct: 366 E--NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRL--EAMLKERESDLSS 421
Query: 452 PRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXX 511
L QD+ K LF + I Q L + +Y+ + K +
Sbjct: 422 KTQLLQDVQDENK---LFKSQIEQ--LKQQNYQ-QASSFPPHEELLKVI----SEREKEI 471
Query: 512 XXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
++ L+ + V+ ++ L + + A + K+L ++++ + E +
Sbjct: 472 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 531
Query: 572 -LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA-SELERSCQVIKQNGFE 629
L E KL VS + L + L+ + KE A + +V++ E
Sbjct: 532 ELEAKEVLKKLFPKVSVPSNLSYG----EWLHGFEKKAKECMAGTSGSEEVKVLEHKLKE 587
Query: 630 LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ-NLALKEQCEEKTRDCSRLEINIKT 688
D+M + + + + +EQ K + +E + +++ + +
Sbjct: 588 ADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTS 647
Query: 689 HEKTAE---IQNRMIMRLQKQIQEDDKLFIEK-ETKLNELTNKYEALKRDYDAAVKDLES 744
E+ E +N+ I L+++ +E ++ +EK E + + + LK K L+
Sbjct: 648 SEQELERLRSENKDIENLRRE-REHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDD 706
Query: 745 S-REAVNQLTTQKDLVEGRIAELESDIRTEQ-----TATVXXXXXXXXXXXXXXXXXXXX 798
S EAV Q + +L++ ++ E + +RTEQ A
Sbjct: 707 SYSEAVRQ-NEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 765
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD 855
T EN D+ +P+ + S K ++SV + V+QL++ L + Q+L KE Y+ L+
Sbjct: 766 DTTVIENSDV--SPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 820
Score = 48.4 bits (110), Expect = 1e-04
Identities = 96/519 (18%), Positives = 209/519 (40%), Gaps = 45/519 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
L E+ + + E L + +++N A I+ +I A A EE ++EK
Sbjct: 16 LMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK 75
Query: 578 DNKLTE----LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
D ++ + L S + L + LK + ++ K + +L+ EL+KM
Sbjct: 76 DKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLK-AEVQKLQALANEQAAAAHELEKM 134
Query: 634 KADILMXXXXXXXXXXXX----XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH 689
+ + + +E K L +QN ALK + ++ + ++ + +
Sbjct: 135 QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL-----QTLVSEQPN 189
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYE---ALKRDYDAAVKDLESSR 746
+ E + I ++++ ++L ET L ++ K E A++ + + K+++ +
Sbjct: 190 KDVVEQMEKCIQEKDEKLKTVEELL---ETGLIQVATKEEELNAIRTENSSLTKEVQDLK 246
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
N + LVE EL+ I + E +
Sbjct: 247 AKQNDQVSFASLVE----ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 302
Query: 807 DLGE---NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L E N +L+ + + SI+ S+V +L+ L +++++ +K +E + + +
Sbjct: 303 ALKEEIGNVQLEKAQQLSIT----SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 358
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+LQ+ E+ LK + Q NLKE Q E + V + + L +++
Sbjct: 359 WLQDLQEENESLKAHVQEVAQH--NLKEASSASQFEELEI----VLKEKENELKRLEAML 412
Query: 924 VDR---MSYDAEV-----EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+R +S ++ ++NK IE+L+ + ++ ++ ++ ++++KE
Sbjct: 413 KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS 472
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREE 1014
EL+ K +E +++ +L E+ E L E+
Sbjct: 473 GLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 511
Score = 32.3 bits (70), Expect = 9.9
Identities = 33/153 (21%), Positives = 64/153 (41%), Gaps = 7/153 (4%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK 85
+ +G K +E + N K++ + S K + ++ S +LE+L E DI+
Sbjct: 608 ETEGILQKLQRSVEQEENKWKVK----VDESHKTIKQMQSSFTSSEQELERLRSENKDIE 663
Query: 86 EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
+ E L R +++++ E+++L + + K L DS ++ EL
Sbjct: 664 NLRREREHLEMELEKAEMERSTYVTEVR--ELKDLLTELQ-KKLDDSYSEAVRQNEELNL 720
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
L+ + + TE + K DL K + L
Sbjct: 721 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 753
>AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein.
Length = 1540
Score = 65.7 bits (153), Expect = 9e-10
Identities = 206/1088 (18%), Positives = 446/1088 (40%), Gaps = 96/1088 (8%)
Query: 46 KLQDSGTITISCKMCQSLKE-SSNEINLKLE--KLSGELFDI-KEQKSALEGKYQNLILE 101
+L DS + +S Q + E NE+ LK+E KL E+ DI + Q L + Q+ E
Sbjct: 182 ELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR-EISDIARRQVEILNAQQQSRDKE 240
Query: 102 TQT--RDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
++ LL Q +S E + K + N++ L +++ + +L+ L + N+
Sbjct: 241 VESLRMQLLDYQAQSDEKSLIAKLHQ-HNVSLQL-SEATALGKLESITSKLQKMEAYNLR 298
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI-GPKNICAQCKLKENLIQSLHIG 218
L+++ L + L + + + G + Q K + +IQ
Sbjct: 299 LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQ----- 353
Query: 219 YDNTLSKLNRSISDSNTSTRYNKICTLQSELDA-GREDCKELCEDFTSIKN----HLELH 273
N K+ + + +S R + TL+ EL G E+ +D + H+++
Sbjct: 354 LQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIE 413
Query: 274 EPNMT-MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL 332
E + + L+ +L ++ E ++SE +R ++SL E+++ +++K H +R
Sbjct: 414 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV----QQNKFHEERQMAWD 469
Query: 333 LAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDL-NECTSELKSVNEKL 391
+D E LD+F+ + I+N Q +E L N+ L+ + E +
Sbjct: 470 QREVDLE---RQLDIFDRQQNEILNAAQ-KFEEATGSIPDPSLPLPNQLEIALRKIKENI 525
Query: 392 ASLNSQLIEKENACNILRIQKERIHEISSAVTI---DIVKKENELKEILTK--ECLKLSK 446
+ +E C L +E++ E SA+ + +I+ ++ + E+ + + K
Sbjct: 526 RII----LETRATCKSL---EEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREK 578
Query: 447 LKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXX 506
L ++ R + + +H + I + E+ K+ RL +
Sbjct: 579 LIAELGRK-EMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKK 637
Query: 507 XXXXXXXXFDTLE----EAHNEVKSLHEELTKLYKSKVDENNANLNLIKI---LSEEIDA 559
LE + N+ K +L K + V N + L ++ ++E+ D+
Sbjct: 638 HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDS 697
Query: 560 LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERS 619
L + K ++ L E+ ++TEL +KE N L + E + +E+E
Sbjct: 698 LSSLLVKLKKVSQDL-ERQREITELK-----VKEFENIKLQLQENHEDEVKKVKAEVEDL 751
Query: 620 CQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
++ Q+ E +K+++ E L+ LALKE+ ++K
Sbjct: 752 KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVER---LKSQLALKEK-QQKALSR 807
Query: 680 SRLEINIK------------THEKTA-----EIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
+ LE+ + T +K A +I +R L+ Q+++ ++ ++ + L
Sbjct: 808 ALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK 867
Query: 723 ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXX 782
N+ +L + + +L+ ++A N++ +K+ ++ EL+ I+ T+ +
Sbjct: 868 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIK-RLTSGLQGKP 926
Query: 783 XXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQ 842
EN+ G+ ++D P + + + E+ + +E Q
Sbjct: 927 LTDNKQSLIEELQRKVKKL--ENQLEGKVEEVDLKPMKEKN--AKEELIRWEEGK-KWQA 981
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ 902
+++ ++ + KE + E T + L + A+ KEKL+L++++ T V++
Sbjct: 982 KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKT------TGMTVDQV 1035
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKM 960
A+ ++++ L +D + + ++ L + +E+L + + L+ + +
Sbjct: 1036 LGIR--ALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHAL 1093
Query: 961 QKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK 1020
+K K T + + C+ E E K+ K E E + L+Q + RLK
Sbjct: 1094 EKQFSKDTYSKPSISGIESD-DHCQREQELQKENLKLSSENIELKFQ-LEQANKDLPRLK 1151
Query: 1021 -EAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
+ + E+ + L +K +++++ + + S T+ + + + + V +EN++
Sbjct: 1152 NQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQ 1211
Query: 1080 LKKMNAKL 1087
LKK + L
Sbjct: 1212 LKKASGIL 1219
Score = 62.1 bits (144), Expect = 1e-08
Identities = 179/966 (18%), Positives = 384/966 (39%), Gaps = 85/966 (8%)
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
+K+ LT + +K N L + L +L EN++ L ++V+ + K E +K
Sbjct: 27 NKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENIS----LKEQVESINKELEITKEKL 82
Query: 183 IDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKI 242
+E+ E E K+G N + K K+++ S + ++ L + + N R
Sbjct: 83 HTIEQAW-EQETKLG--NESSMDKAKKSITNSDIVSISKKITMLE--MKELNERQRAEHC 137
Query: 243 CTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ L + +E +F EL + N+ E++ + ++ + V
Sbjct: 138 QKMYEHLRTSLKQMEE--RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD 195
Query: 303 KRNLNSLSEQLINNESKKSK-DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI 361
++ + L + + + + SK I + +L+A+ + +V + M + + Q
Sbjct: 196 RQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQS 255
Query: 362 DLDEILEKYTK--VQGDLNECTS--ELKSVNEKLAS-------LNSQLIEKENACNILRI 410
D ++ K + V L+E T+ +L+S+ KL L +L EKE A R+
Sbjct: 256 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 315
Query: 411 Q-KERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILF 469
+ + R + TI ++++ L ++ K SK I + D K+ I+
Sbjct: 316 EGRNRAKHLRQ--TIQSLRRQFSGALPLAQQ-EKFSKTMIQLQND---------KLKIMQ 363
Query: 470 DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHNEVKSL 528
+ +Q E + + + +L+L+ G + + + +EE + L
Sbjct: 364 EMKNSQQEHRNMENKTLEMELKLK-GLEELISTLKDTKGAQKVINWHMKIEELRLQELKL 422
Query: 529 HEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK----NEEKMLSLSEKDNKLTEL 584
+ EL K K ++ N N+I I +L+ I + +EE+ ++ +++ L
Sbjct: 423 NRELVK-DKEEIKYLN---NIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQ 478
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI--LMXXX 642
+ + +++N L + + +E S + S + Q L K+K +I ++
Sbjct: 479 LDIFD--RQQNEILNAAQ----KFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETR 532
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI-QNRMIM 701
+ A L EQN+ +++ + R RL + + AE+ + M
Sbjct: 533 ATCKSLEEKLKEKESALRLAEQNILSRDKVINELR--LRLPATAEREKLIAELGRKEMEP 590
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
+ ++ + + +LN+ K E LK+ K E RE V + ++
Sbjct: 591 KSHHTLKIAHQTIANMQARLNQ---KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHH 647
Query: 762 RIAELESDI---RTEQTA--TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG------E 810
R+ EL++D + +QTA + T +++ L +
Sbjct: 648 RL-ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLK 706
Query: 811 NPKLDDSPKRSISVISDSEVSQLK--------ERLLSCQQELDDLKERYKELDDECETCA 862
D +R I+ + E +K + + + E++DLK + E +
Sbjct: 707 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK 766
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
LQ + E A + ++ V LK Q+ ++ ++ A + + + A +
Sbjct: 767 SELQAQKE--ANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERI 824
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
+ +A + + + + EL+ + +DL + K+++A++ T K++E + L
Sbjct: 825 ISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK--TSKNRE-NSLTDNLN 881
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQ 1042
D EL++ ++ Y ++ E E + + + Q KRL + D + L+++
Sbjct: 882 DLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRK 941
Query: 1043 IESLSN 1048
++ L N
Sbjct: 942 VKKLEN 947
Score = 56.0 bits (129), Expect = 7e-07
Identities = 215/1102 (19%), Positives = 436/1102 (39%), Gaps = 120/1102 (10%)
Query: 59 MCQSLKESSNEINLKLEKLS--GELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLE 116
+ Q K S I L+ +KL E+ + +++ +E K + L+ + + L+S +K +
Sbjct: 341 LAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTK 400
Query: 117 MENLTKDKEIKNLTDSLKTKSKKIN-EL---QEENDTLSNLIMENVTESDNLNKEVDDLK 172
+ +K + L+ + K+N EL +EE L+N+I E +L +E+
Sbjct: 401 GAQKVINWHMK--IEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQN 458
Query: 173 KNNE----CLTQKCIDLEK---LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
K +E Q+ +DLE+ + + +N+I N + + I + N L
Sbjct: 459 KFHEERQMAWDQREVDLERQLDIFDRQQNEI--LNAAQKFEEATGSIPDPSLPLPNQLEI 516
Query: 226 LNRSISDS-NTSTRYNKICTLQSELDAGREDCKELCEDFT----SIKNHLELHEPNMTMD 280
R I ++ C E +E L E + N L L P T +
Sbjct: 517 ALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLP-ATAE 575
Query: 281 LDEKLGE--NNEFETKAVKVMSEIKRNLNSLSEQLINNES--KKSKDHIDRYKDSLLAVL 336
++ + E E E K+ + + + ++ +L E KK + +++ ++ ++
Sbjct: 576 REKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIV 635
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE---KLAS 393
E + + ++ ++ D L K+ + DL + + N+ +LA
Sbjct: 636 KKH---------EEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 686
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
+ + E++++ + L ++ +++ + D+ +++ E+ E+ KE +K+ +
Sbjct: 687 MEQTVAEQDDSLSSLLVKLKKVSQ-------DL-ERQREITELKVKE---FENIKLQLQE 735
Query: 454 DLDQDLPAHKK----ITILFDALITQYELSRTDYEIEKE-KLRLETGTAKAVXXXXXXXX 508
+ + ++ K + L D + + +++ + +KE R T T + +
Sbjct: 736 NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 795
Query: 509 XXXXXXFDTLEEAHNEVKS-LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN 567
L A E+++ + + S + A+LN+ +I+ LK +
Sbjct: 796 ALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDL 855
Query: 568 EEKMLSLSE----KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
E +L L E N+ L +N L E + + I REKE E+++
Sbjct: 856 NENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKE----EIDQ----- 906
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
E D++K I D +SL+E+ L K + E + E
Sbjct: 907 -----ENDELKRQI-----KRLTSGLQGKPLTDNKQSLIEE-LQRKVKKLENQLEGKVEE 955
Query: 684 INIKT-HEKTAE---IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
+++K EK A+ I+ + Q +I+ EKE ++ LT + LK + A
Sbjct: 956 VDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKAD 1015
Query: 740 KDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
K+ + + + D V G I LES+ E+
Sbjct: 1016 KEKLTLQRKLKTTGMTVDQVLG-IRALESEKELEELKKRNLDLENDILYMRAHQALPRDS 1074
Query: 800 TFGD---ENRDLGENPKL-------DDSPKRSISVISDSEVSQLKERL----LSCQQELD 845
D +NR L E D K SIS I + Q ++ L L E
Sbjct: 1075 VVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENI 1134
Query: 846 DLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
+LK + ++ + + +++ E C LKKEK +++++ +++ R+ + +
Sbjct: 1135 ELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL--- 1191
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
E L VV+++ + E K + T E++ +Q+ + +++K
Sbjct: 1192 --------EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 1243
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
+ +E+K K E AE E L+ KEL +E + AE L+ + + L E K+
Sbjct: 1244 HLGHQLSMHYESKTKGTEKIIAENERLR---KELKKETD-AAEKLRIAKNNLEILNE-KM 1298
Query: 1025 ALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI-TDVMKENQKLKKM 1083
+++ + + A E + L + V T + +++ TD+ K+NQ + +
Sbjct: 1299 TVQLEETGKRLQFA-ESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDL 1357
Query: 1084 NAKLITICKKRGKTGANRENED 1105
+L+ +R + N+ NED
Sbjct: 1358 K-QLVKEATER-EQKVNKYNED 1377
Score = 54.8 bits (126), Expect = 2e-06
Identities = 188/1010 (18%), Positives = 398/1010 (39%), Gaps = 98/1010 (9%)
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSK-KINELQEENDTLSNLI 154
+N LET+ +L + + ++E + +D+ +++ ++ + +I EL++ L +
Sbjct: 154 RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEV 213
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
+ SD ++V+ L + ++ L + + + + K++ A KL ++ + S
Sbjct: 214 SKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIA--KLHQHNV-S 270
Query: 215 LHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDA-----------GREDCKELCEDF 263
L + L KL S YN L+ +LD GR K L +
Sbjct: 271 LQLSEATALGKLESITSKLQKMEAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTI 328
Query: 264 TSIKNHLELHEPNMTMDLDEKLGENN-EFETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
S++ P + EK + + + +K+M E+K NS E N E+K +
Sbjct: 329 QSLRRQFSGALP---LAQQEKFSKTMIQLQNDKLKIMQEMK---NSQQEHR-NMENKTLE 381
Query: 323 DHID-RYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT 381
+ + + L++ L G + + + ++ + ++ L+ L K + LN
Sbjct: 382 MELKLKGLEELISTLKDTKGAQKVINWHMKIEEL-RLQELKLNRELVKDKEEIKYLNNII 440
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
SE + ++SL ++++ +N + R E+ +DI ++ EIL
Sbjct: 441 SEYERT---ISSLEEEIVQ-QNKFHEERQMAWDQREVDLERQLDIFDRQQN--EILNA-A 493
Query: 442 LKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLET-GTAKAV 500
K + IP D LP L Q E++ + E ++ LET T K++
Sbjct: 494 QKFEEATGSIP---DPSLP-----------LPNQLEIALRKIK-ENIRIILETRATCKSL 538
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDAL 560
+ + L L ++ ++ A L ++ + L
Sbjct: 539 EEKLKEKESALRLAEQNILSRDKVINELRLRLPAT--AEREKLIAELGRKEMEPKSHHTL 596
Query: 561 KIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLND----VITREKETQASEL 616
KIA L++K+ L + + +EE + ++ ++ E QA
Sbjct: 597 KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQA--- 653
Query: 617 ERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT 676
+ S KQ ++L K + ++ SL + LK+ ++
Sbjct: 654 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE 713
Query: 677 RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD 736
R E+ +K E +N ++LQ Q +D++ K ++ +L + +++
Sbjct: 714 RQREITELKVK------EFEN---IKLQLQENHEDEVKKVK-AEVEDLKYLLDQSQKESQ 763
Query: 737 AAVKDLESSREAVNQL--TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+L++ +EA ++ TT ++LVE ++L ++ +Q +
Sbjct: 764 CLKSELQAQKEANSRAPTTTMRNLVERLKSQLA--LKEKQQKALSRALLELRAEMTAAAE 821
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
+ L ++ D R + ++V L E LL ++ L K R L
Sbjct: 822 ERIISATSQKEAHLNVQ-QIVDRHTRELK----TQVEDLNENLLKLKEALKTSKNRENSL 876
Query: 855 DDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE 914
D LQ++ + ++ +EK ++Q+ LK QI+ + D
Sbjct: 877 TDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTD------- 929
Query: 915 DWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
N S++ + ++E +L +EE+ K KN ++ + E+ K +
Sbjct: 930 ---NKQSLIEELQRKVKKLE--NQLEGKVEEVDLKPMKEKNAKEELIR-WEEGKKWQAKI 983
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
E R +L++ + E+ L K+L+ + A+ K++ ++LK + ++ V L
Sbjct: 984 EGIRNKLKEKEGEVFTLT---KQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQV--LGI 1038
Query: 1035 QKVALEKQIESLS--NTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ + EK++E L N + N +Y+ A+ ++ + D+ +N+ L++
Sbjct: 1039 RALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE 1088
Score = 50.0 bits (114), Expect = 5e-05
Identities = 158/788 (20%), Positives = 319/788 (40%), Gaps = 97/788 (12%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGE-LF 82
+++L K N T + + + + K ++L + E+ ++ + E +
Sbjct: 766 KSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERII 825
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
QK A Q I++ TR+L +Q++ L ENL K KE +LKT + N
Sbjct: 826 SATSQKEAHLNVQQ--IVDRHTREL-KTQVEDLN-ENLLKLKE------ALKTSKNRENS 875
Query: 143 LQEENDTLSNLIMEN-------VTESDNLNKEVDDLKKNNECLTQ----KCI--DLEKLV 189
L + + L+N + + + E + +++E D+LK+ + LT K + + + L+
Sbjct: 876 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 935
Query: 190 NESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY----NKICTL 245
E + K+ K + Q + K + + N +L R + NK+
Sbjct: 936 EELQRKV--KKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK 993
Query: 246 QSELDAGREDCKELCEDFTSI-KNHLELHEPNMT--MDLDEKLG---ENNEFETKAVKVM 299
+ E+ + L + F K L L T M +D+ LG +E E + +K
Sbjct: 994 EGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKR 1053
Query: 300 SEIKRN--LNSLSEQLINNESKKSKDHI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
+ N L + Q + +S H+ +RY L L+ +F + I
Sbjct: 1054 NLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESD 1113
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK---- 412
+ Q + E+ ++ K+ + E +L+ N+ L L +Q+ + + C L+ +K
Sbjct: 1114 DHCQRE-QELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 1172
Query: 413 -------------ERIHEISSAV-----TIDIVKKENE-LKE---ILTKECL-KLSKLKI 449
+ I E+ + ++ V++ENE LK+ ILT E + + +
Sbjct: 1173 RKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 1232
Query: 450 DIPRDLDQDLPAH--KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXX 507
+ +L++ L AH ++++ +++ E + E +++L+ ET A+ +
Sbjct: 1233 KLKAELEK-LKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL 1291
Query: 508 XXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN 567
LEE ++ +L + ++ ++ + ++ ++ L+ IAK
Sbjct: 1292 EILNEKMTVQLEETGKRLQFAESRGPQL-EGADSKSWKSIVVTRMYETKLKELETDIAKK 1350
Query: 568 EEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNG 627
+ + L + + TE +N E+ + + ET+ L+R QV++
Sbjct: 1351 NQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG-LKRELQVLRLAN 1409
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIK 687
+LDK KA+++ ++ +S E + +Q +EK +D LE +K
Sbjct: 1410 HQLDKEKAELI------------HQIEANKDQSGAESTIPDADQLKEKIKD---LETQLK 1454
Query: 688 THEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSRE 747
+ + I +L+K+++ D F E + E LK +Y VK E
Sbjct: 1455 MSDLEKQHLKEEIKKLKKELENFDPSFFE----------EIEDLKYNYKEEVKKNILLEE 1504
Query: 748 AVNQLTTQ 755
V +L+ Q
Sbjct: 1505 KVKKLSEQ 1512
Score = 46.8 bits (106), Expect = 4e-04
Identities = 178/894 (19%), Positives = 353/894 (39%), Gaps = 97/894 (10%)
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE--KLVNESENKIGPKNIC 202
E++D+LS+L+++ L K DL++ E K + E KL + ++ K +
Sbjct: 693 EQDDSLSSLLVK-------LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVK 745
Query: 203 AQCK-LKENLIQSLHIGY--DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKEL 259
A+ + LK L QS + L + S + T+T N + L+S+L + K L
Sbjct: 746 AEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKAL 805
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
LEL MT +E++ + S+ + +LN +Q+++ ++
Sbjct: 806 SRAL------LELRA-EMTAAAEERI----------ISATSQKEAHLNV--QQIVDRHTR 846
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K ++ ++LL + +A TS + L DN+ N +L + + Y K+ + E
Sbjct: 847 ELKTQVEDLNENLLKLKEAL--KTSKNRENSLTDNL-NDLNNELQKKQKAYNKILREKEE 903
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK 439
E + ++ L S L K N ++ I E+ V K EN+L+ + +
Sbjct: 904 IDQENDELKRQIKRLTSGLQGKPLTDN----KQSLIEELQRKVK----KLENQLEGKVEE 955
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD-YEIEKEKLRLETGTAK 498
LK K K + +L + KK + + + + + + + K+ L+ AK
Sbjct: 956 VDLKPMKEK-NAKEELIR-WEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAK 1013
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI--KILSEE 556
A + +EL +L K +D N L + + L +
Sbjct: 1014 ADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRD 1073
Query: 557 --IDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
++ L + +EK+ +L ++ +K T +I+G++ + D RE+E Q
Sbjct: 1074 SVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESD--------DHCQREQELQKE 1125
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
L+ S + I+ F+L++ D+ E L++ A ++
Sbjct: 1126 NLKLSSENIELK-FQLEQANKDL--------PRLKNQVRDLKEMCEFLKKEKAEVQRKLG 1176
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK----LFIEKETKLNELTNKYEA 730
R R I EKT + +++ ++Q++ ++ K L EK + + K +A
Sbjct: 1177 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKA 1236
Query: 731 LKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXX 790
A + S T+K + E L +++ E A
Sbjct: 1237 ELEKLKAHLGHQLSMHYESKTKGTEKIIAENE--RLRKELKKETDAAEKLRIAKNNLEIL 1294
Query: 791 XXXXXXXXXTFGDENRDL-GENPKLDDSPKRS-----ISVISDSEVSQLKERLLSCQQEL 844
G + P+L+ + +S ++ + ++++ +L+ + Q +
Sbjct: 1295 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSI 1354
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKK--EKLSLEQQVSNLKEQIR-TQQPVER 901
DLK+ KE + + +Y ++ ++Q LK E EQ + + +R +++
Sbjct: 1355 TDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDK 1414
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
+ + ++D + S + D D EK K L ++ +KQ LK + K++
Sbjct: 1415 EKAELIHQIEANKDQSGAESTIPDA---DQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 1471
Query: 962 KAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
K +E + D F E+E+LK YKE ++ E +K+ EQ
Sbjct: 1472 KELENF---DPSFFE----------EIEDLKYNYKEEVKKNILLEEKVKKLSEQ 1512
Score = 40.7 bits (91), Expect = 0.028
Identities = 187/1064 (17%), Positives = 404/1064 (37%), Gaps = 69/1064 (6%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEG---KYQNLILETQTRDLLMSQIKSLEMENLTKDKE 125
E+ L+ KL+ EL KE+ L +Y+ I + + ++ Q K E + D+
Sbjct: 414 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTI--SSLEEEIVQQNKFHEERQMAWDQR 471
Query: 126 IKNLTDSLKTKSKKINEL----QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQK 181
+L L ++ NE+ Q+ + ++ ++ + L + +K+N + +
Sbjct: 472 EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 531
Query: 182 ---CIDLEKLVNESEN--KIGPKNICAQCKLKENLIQSLHIGYDNT--LSKLNRSISDSN 234
C LE+ + E E+ ++ +NI ++ K+ L L + +++L R +
Sbjct: 532 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 591
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFET 293
+ + + A +E+ + + + + + +E L ++ E
Sbjct: 592 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 651
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
+A +++ K+ L +Q + + H R + V + + +SL V +
Sbjct: 652 QADSSLNKFKQTAWDLMKQ--SPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVS 709
Query: 354 NIINKYQIDLDEI-LEKYTKVQGDLNEC-TSELKSVNEKLASLNSQL--IEKENAC--NI 407
+ + Q ++ E+ ++++ ++ L E E+K V ++ L L +KE+ C +
Sbjct: 710 QDLER-QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSE 768
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI-- 465
L+ QKE + ++V++ + K+ LS+ +++ ++ A ++I
Sbjct: 769 LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTA--AAEERIIS 826
Query: 466 -TILFDA-LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
T +A L Q + R E++ + L K + D L + +N
Sbjct: 827 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLK-LKEALKTSKNRENSLTDNLNDLNN 885
Query: 524 EVKSLHEELTKLYKSK--VDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
E++ + K+ + K +D+ N L IK L+ + + + K + E K
Sbjct: 886 ELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLT----DNKQSLIEELQRK 941
Query: 581 LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
+ +L + + G K E LK + + +E+ + E ++ I+ +L + + ++
Sbjct: 942 VKKLENQLEG-KVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF-T 999
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE---KTAEIQN 697
D+ K L++ L ++ LE + E + +++N
Sbjct: 1000 LTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEN 1059
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDA------AVKDLESSREAVNQ 751
++ Q D + + + L K AL++ + ++ +ES +
Sbjct: 1060 DILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQRE 1119
Query: 752 LTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
QK+ ++ +E + EQ A + R LG
Sbjct: 1120 QELQKENLKLSSENIELKFQLEQ-ANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV 1178
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
S K + + + +K+ + Q+E + LK+ L E A QE ++
Sbjct: 1179 RGSGRSGKTIPEL--EKTIGLMKKVVEKVQRENEQLKKASGILTSE--KMANIEQENEKL 1234
Query: 872 CARLKKEKLSLEQQVS-NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD 930
A L+K K L Q+S + + + + + + + + + + D A + + +
Sbjct: 1235 KAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEI- 1293
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKK---DKEFEAKRKELEDCKAE 987
N+++ +EE + Q ++ +++ A K K + +E K KELE A+
Sbjct: 1294 ----LNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAK 1349
Query: 988 ----LEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+ +LKQ KE E + +Y + E+Q K LK E L + L
Sbjct: 1350 KNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLAN 1409
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
L A I D + +K+K + +L
Sbjct: 1410 HQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 1453
Score = 33.1 bits (72), Expect = 5.7
Identities = 51/255 (20%), Positives = 104/255 (40%), Gaps = 15/255 (5%)
Query: 843 ELDDLKERYKELDDECETCAE---YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
EL+ ++Y EL + + L +R L+ E +SL++QV ++ +++
Sbjct: 22 ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEI---T 78
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
+ + + A + N S+ D+ + K I L K+ + +
Sbjct: 79 KEKLHTIEQAWEQETKLGNESSM--DKAKKSITNSDIVSISKKITMLEMKELNERQRAEH 136
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELK---QRYKEL--DEECETCAEYLKQREE 1014
QK E K+ E + ELE AEL ++ Q+ +++ DE ++ ++ + +
Sbjct: 137 CQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADR 196
Query: 1015 Q-CKRLKEAKIALEI-VDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITD 1072
Q L++ ++ L++ V KL +Q+E L+ S + ++ Q +D
Sbjct: 197 QRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD 256
Query: 1073 VMKENQKLKKMNAKL 1087
KL + N L
Sbjct: 257 EKSLIAKLHQHNVSL 271
>J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplakin
mRNA, 3' end. ).
Length = 1752
Score = 65.3 bits (152), Expect = 1e-09
Identities = 171/910 (18%), Positives = 361/910 (39%), Gaps = 91/910 (10%)
Query: 162 DNLNKEVDDLKKNNEC----LTQKCIDLEKLVNESENKIGPKNICAQ-----CKLKENLI 212
D + D L+K +C L + ++ EK + E E +I + Q + EN +
Sbjct: 14 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENEL 73
Query: 213 QSLHIGYDNTLSKL-NRSISDSNTSTRYNKICTLQSELDAG--REDCKELCEDFTSIKNH 269
+ Y+ +S L N+ ++ N + K ++Q E D+ R L + +K+
Sbjct: 74 AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDE 133
Query: 270 L-ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRY 328
+ L++ + + E N + KA SEI + L +L ++S+D+ R+
Sbjct: 134 IVRLNDSILQATEQRRRAEENALQQKACG--SEIMQKKQHLEIELKQVMQQRSEDNA-RH 190
Query: 329 KDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
K SL E T D + I + + + E ++ + + +L++ + + +
Sbjct: 191 KQSL-----EEAAKTIQD-----KNKEIERLKAEFQEEAKRRWEYENELSKVRN---NYD 237
Query: 389 EKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLK 448
E++ SL +Q E E + I K IH+++ D ++ LT+E LS+
Sbjct: 238 EEIISLKNQF-ETE-----INITKTTIHQLTMQKEEDTSGYRAQIDN-LTRENRSLSEEI 290
Query: 449 IDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
+ L Q +++ + I Q + + ++ K++L +E +
Sbjct: 291 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRY 346
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+L++A ++ ++E+ +L K +D+ N K L +E A+ +
Sbjct: 347 K------QSLDDAAKTIQDKNKEIERL-KQLIDKET---NDRKCLEDEN-------ARLQ 389
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
L + ++ TE ++ + ++E L+ + +++E+ + ++ R +K+
Sbjct: 390 RVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQL 449
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
+ K++ ++ +E + + +LKEQ + T +LE
Sbjct: 450 QKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIV 506
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
+++ + + L ++E + + +L L+++ EAL+R +++ ES ++A
Sbjct: 507 KKRSEDDLRQQRDVLDGHLREKQRT----QEELRRLSSEVEALRRQL---LQEQESVKQA 559
Query: 749 VNQLTTQKDLVEGRIAEL-ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ + +E + L ES I E+ ++ E D
Sbjct: 560 HLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRL-----EYDD 614
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE 867
L DS K + + S++ R L Q ++DL+ + L E E
Sbjct: 615 LRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE-------- 666
Query: 868 RDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
+ +K+ L ++ K Q TQ ER++ + V ++D A L + +
Sbjct: 667 ------KFQKQALEASNRIQESKNQC-TQVVQERESLLVKIKV-LEQDKARLQRLEDELN 718
Query: 928 SYDAEVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA 986
+ +E R+ + +E E + + DL T+ + E K + E E +E ++
Sbjct: 719 RAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS 778
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
E+E L+ K ++E C E RE Q + E +DKL + ++ ++
Sbjct: 779 EIERLQAEIKRIEERCRRKLED-STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE 837
Query: 1047 SNTPVSNSTM 1056
V S +
Sbjct: 838 CEWTVDTSKL 847
Score = 59.3 bits (137), Expect = 8e-08
Identities = 160/800 (20%), Positives = 325/800 (40%), Gaps = 73/800 (9%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL-FDI 84
+L+ K+ + E + + LQ+ GT + L + N N ++ L + +I
Sbjct: 38 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYE--NELAKVRNHYNEEMSNLRNKYETEI 95
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
K+ + K ++ E +++L +Q+ L EN EI L DS+ +++ +
Sbjct: 96 NITKTTI--KEISMQKEDDSKNL-RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE 152
Query: 145 E---ENDTLSNLIMENVTESD-NLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKN 200
E + + IM+ + L + + ++N Q + K + + +I
Sbjct: 153 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 212
Query: 201 ICAQCKLK-----ENLIQSLHIGYDNTLSKL-NRSISDSN-TSTRYNKICTLQSELDAG- 252
Q + K EN + + YD + L N+ ++ N T T +++ T+Q E D
Sbjct: 213 AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL-TMQKEEDTSG 271
Query: 253 -REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
R L + S+ ++ + +T E L E + SE+ + L
Sbjct: 272 YRAQIDNLTRENRSLSEEIKRLKNTLTQTT-ENLRRVEEDIQQQKATGSEVSQRKQQLEV 330
Query: 312 QLINNESKKSKDHIDRYKDSLL-AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
+L ++++ + RYK SL A + ++ + L+D N + L++ +
Sbjct: 331 ELRQVTQMRTEESV-RYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC-LEDENARL 388
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+VQ DL + S S E + L Q E LRI ER+ + + DI + +
Sbjct: 389 QRVQYDLQKANS---SATETINKLKVQ----EQELTRLRIDYERVSQERTVKDQDITRFQ 441
Query: 431 NELKEI-LTKECLK--LSKLKIDIPRD------LDQDLPAH----KKITILFDALITQYE 477
N LKE+ L K+ ++ L++LK D L+++L K+ I L Q E
Sbjct: 442 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 501
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL-- 535
+ + ++ LR + +E ++ E + +
Sbjct: 502 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 561
Query: 536 ----YKSKVDENNANLNLIKILSEEIDALKIAIAKN----EEKMLSLSEKDNKL----TE 583
++ +++ + +LN KI E + +L + K EE++ +L + + L +E
Sbjct: 562 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 621
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
S N E S +++ T E + ++L+R + ++Q E++K + L
Sbjct: 622 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQ---EIEKFQKQALEASNR 678
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E +SLL + L++ +K R RLE + + T E + R+ RL
Sbjct: 679 IQESKNQCTQVVQERESLLVKIKVLEQ---DKAR-LQRLEDELNRAKSTLEAETRVKQRL 734
Query: 704 Q---KQIQED----DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ- 755
+ +QIQ D + KE + ++ ++ E +R+ ++ ++E + + ++ +
Sbjct: 735 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERC 794
Query: 756 KDLVEGRIAELESDIRTEQT 775
+ +E E +S + TE++
Sbjct: 795 RRKLEDSTRETQSQLETERS 814
>BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase 1 protein.
Length = 1354
Score = 65.3 bits (152), Expect = 1e-09
Identities = 125/710 (17%), Positives = 290/710 (40%), Gaps = 56/710 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ES + KLE+ +L + + K +E K + ++ D +M ++ +
Sbjct: 422 KSLQESLQKTIYKLEE---QLHNEMQLKDEMEQKCRTSNIKL---DKIMKELDEEGNQRR 475
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK---NNEC 177
+ + + +INE Q + + + E L +++DLKK N++
Sbjct: 476 NLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQL 535
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
+K L+K + E+ + + ++ A K + S I + L LNR + + N
Sbjct: 536 ANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSI---SQLESLNRELQERNRIL 592
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
+K S+ D + + E + H + M DL ++ E E K +K
Sbjct: 593 ENSK-----SQTDKDYYQLQAILEAERRDRGH----DSEMIGDLQARITSLQE-EVKHLK 642
Query: 298 V-MSEIKRNLNSLSEQLINNESKKSKDHID-RYK-DSLLAVLDAEFGTTSLDVFEIL--M 352
+ +++ + L ++E +K+ ID YK SL L+ E + +
Sbjct: 643 HNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKH 702
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+I + + E+ +K + + + + + + ++ + L+ L + + L K
Sbjct: 703 QSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNK 762
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
ER+ + +T+ + ++ N K +L + LK + D + L++ + ++I L +A
Sbjct: 763 ERMEDEVKNLTLQLEQESN--KRLLLQNELKTQAFEADNLKGLEKQMK--QEINTLLEAK 818
Query: 473 -ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
+ ++EL++ ++ R G + + ++E E++ + E
Sbjct: 819 RLLEFELAQLT-----KQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873
Query: 532 LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK--------LTE 583
K + +E + + + ++ ++A EE+ L+++ K +T+
Sbjct: 874 NLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITD 933
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK-QNGFELDKMKA----DIL 638
T++ L+E N+ L +++ RE E ++++ + K + E+ +KA +I
Sbjct: 934 KDHTVSRLEEANSMLTKDIEILRRENEELTERMKKAEEEYKLEKEEEISNLKAAFEKNIN 993
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ +++ A + +K ++ +L++ + E N+
Sbjct: 994 TERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQER---EKFNQ 1050
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLESS 745
M+++ QK++ + +E+ NEL + + + D + A + DL S
Sbjct: 1051 MVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDS 1100
Score = 49.2 bits (112), Expect = 8e-05
Identities = 89/446 (19%), Positives = 170/446 (38%), Gaps = 29/446 (6%)
Query: 668 LKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK 727
+ ++ +E+ LE + EK + I Q++ +++++ E +++ L N+
Sbjct: 463 IMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQ 522
Query: 728 YEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXX 787
E LK+ ++ + + E ++QL QK L E +L +RTE V
Sbjct: 523 LEDLKK----VSQNSQLANEKLSQL--QKQLEEAN--DL---LRTESDTAVRLRKSHTEM 571
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL---KERLLSCQQEL 844
+ NR L + D + I ++E E + Q +
Sbjct: 572 SKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARI 631
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS-NLKE-QIRTQQPVERQ 902
L+E K L E +E + +KEK +LE ++ LK Q R +Q V
Sbjct: 632 TSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEH 691
Query: 903 AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQ------DLKNT 956
+ + SV + M + E+ R ++ +KQ DLK +
Sbjct: 692 KVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQS 751
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
K++ + + E + +LE + L+ K E + KQ +++
Sbjct: 752 QQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEI 811
Query: 1017 KRLKEAKIALEI-VDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMK 1075
L EAK LE + +L+ Q E Q+ L + + Y +T + Q+ ++ +
Sbjct: 812 NTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQ--LEAEQYFST----LYKTQVKELKE 865
Query: 1076 ENQKLKKMNAKLITICKKRGKTGANR 1101
E ++ + N K I + +T A +
Sbjct: 866 EIEEKNRENLKKIQELQNEKETLATQ 891
Score = 44.4 bits (100), Expect = 0.002
Identities = 104/515 (20%), Positives = 205/515 (39%), Gaps = 56/515 (10%)
Query: 523 NEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLT 582
NEV +L +L L K + AN L + L ++++ + + + L + T
Sbjct: 514 NEVSTLKNQLEDLKKVSQNSQLANEKLSQ-LQKQLEEANDLLRTESDTAVRLRKSH---T 569
Query: 583 ELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXX 642
E+ +I+ L+ N L+ N ++ K +Q + Q I L+ + D
Sbjct: 570 EMSKSISQLESLNRELQERNRILENSK-SQTDKDYYQLQAI------LEAERRDRGHDSE 622
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ-NRMIM 701
+E K L + NL E+ E + ++ + + + + EI N +
Sbjct: 623 MIGDLQARITSLQEEVKHL-KHNL---EKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLK 678
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV----KDLESSREAVNQLTTQKD 757
LQ++++++ + K TK LT+K+++++ A+ K L+ REA + +
Sbjct: 679 SLQQRLEQE--VNEHKVTKAR-LTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVV 735
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK---L 814
+E + + L+ D++ Q ++ L K
Sbjct: 736 QIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAF 795
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYK-------ELDDECETCAEYLQE 867
+ + + E++ L E + EL L ++Y+ EL D+ E +Y
Sbjct: 796 EADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEA-EQYFST 854
Query: 868 RDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
+ + KE++ E+ NLK+ Q E A D+A T + L +++
Sbjct: 855 LYKTQVKELKEEIE-EKNRENLKKIQELQNEKETLATQLDLA-ETKAESEQLARGLLEEQ 912
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
++ E K + +E+ D +TV+++++A TK ++E + E
Sbjct: 913 YFELTQESKKAASRNRQEIT----DKDHTVSRLEEANSMLTK----------DIEILRRE 958
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRLKEA 1022
EEL +R K+ +E EY ++EE+ LK A
Sbjct: 959 NEELTERMKKAEE------EYKLEKEEEISNLKAA 987
Score = 39.9 bits (89), Expect = 0.049
Identities = 34/179 (18%), Positives = 85/179 (47%), Gaps = 6/179 (3%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+S+ + +L+E+L + Q D+++++ + + + + + L E Q L+
Sbjct: 422 KSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTV 481
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVD--RMSYDAEV--EK 935
+E++ L+ +I Q Q + N + + + L + + D ++S ++++ EK
Sbjct: 482 SQIEKEKMLLQHRINEYQRKAEQEN--EKRRNVENEVSTLKNQLEDLKKVSQNSQLANEK 539
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
+L K +EE + +T +++K+ + +K + E+ +EL++ LE K +
Sbjct: 540 LSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQ 598
>BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 14
protein.
Length = 980
Score = 65.3 bits (152), Expect = 1e-09
Identities = 115/536 (21%), Positives = 227/536 (42%), Gaps = 43/536 (8%)
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I +L S +I +LQE L + + E L E+ + CL I
Sbjct: 417 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-- 474
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
+E+ + + K Q K +E + + L + L ++ D+ + ++++
Sbjct: 475 ----SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYS--HFHELRVT 528
Query: 246 QSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGEN-NEFETKAVKVMSEIK 303
+ E++ ++D + E+ K + EL E + + + E+E S I+
Sbjct: 529 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 588
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL--MDNIINKYQI 361
N+N + + + +++++ I + KD+L + + E + D+ E + M + +NK
Sbjct: 589 -NMNK-EKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 646
Query: 362 DLDEI-------LEKYTKVQGDLNECTSEL--KSVNEKLASL-NSQLIEKENACNILRIQ 411
+L ++ LE Y K + L + T+E K+ +EKL L N + E+A + ++ Q
Sbjct: 647 ELSQLYKEAQAELEDYRK-RKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 705
Query: 412 KERI-HEISSAVTIDIVKKENELK-----EILT------KECL-KLSKLKIDIPRDLDQD 458
++ +E++ + +KEN + +++T KE K+S LK + + +
Sbjct: 706 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASK-EVE 764
Query: 459 LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
+ +K + A +T + R+ YE + L E + +
Sbjct: 765 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 824
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
++VK E + L KSK E N L + EE+ +K +++ K+ +KD
Sbjct: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMK-RYSESSSKL--EEDKD 881
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
K+ E+ + LKE NSL L+ T + Q+ +LE Q +KQ +L + K
Sbjct: 882 KKINEMSKEVTKLKEALNSLSQLS-YSTSSSKRQSQQLEALQQQVKQLQNQLAECK 936
Score = 62.5 bits (145), Expect = 8e-09
Identities = 116/588 (19%), Positives = 252/588 (42%), Gaps = 55/588 (9%)
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
L KS D N+ + ++ + +++ ++ ++ E K L + E ++ ELV N E
Sbjct: 420 LGKSTTD-NDVRIQQLQEILQDLQK-RLESSEAERKQLQV-ELQSRRAELVCLNNTEISE 476
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
N+S D+ + KETQ+ E +V+ +MK ++
Sbjct: 477 NSS-----DLSQKLKETQSKYEEAMKEVLSVQ----KQMKLGLVSPESMDNYSHFHELRV 527
Query: 655 XDEAKSLLEQNL--ALKE--QCEEKTRDCSRLEIN------IKTH-EKTAEIQNRMIMRL 703
+E ++L+Q+L AL+E + +EK R+ + IK E+ E+++ +
Sbjct: 528 TEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 587
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
+ +E LF + + E+ + LK D E +EA+N++ + +
Sbjct: 588 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 647
Query: 763 IAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
+++L + + E + + +R E+ L + +
Sbjct: 648 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDA-LSEMKSQY 706
Query: 822 ISVISD-SEVSQL----KERLLSCQQELD---DLKERYKELDDECETCAEYLQERDEQCA 873
V+++ +++ QL KE +S + L L+ KE++++ E+L ++ + A
Sbjct: 707 SKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVA 766
Query: 874 RLKK----EKLSLEQQVSNLKEQIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMS 928
+L+K EK ++ + + Q +E + A + ++ +HS VV S
Sbjct: 767 KLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRS 826
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
++V++ K ++T+ L+ K+Q++ + K Q+A E+ + + E+ K ED ++
Sbjct: 827 EVSQVKREKENIQTL--LKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKDKKI 884
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
E+ + +L E + ++ ++ ++ + + V +L NQ +KQ + +
Sbjct: 885 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV-- 942
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+S M++ VQ Q DV QK+ K +++T+CK + +
Sbjct: 943 --ISVYRMHLLYA---VQGQMDEDV----QKVLK---QILTMCKNQSQ 978
Score = 58.8 bits (136), Expect = 1e-07
Identities = 106/506 (20%), Positives = 219/506 (43%), Gaps = 52/506 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLN--LIKILSEEIDALKIAIAKNEEKMLSL---SEKD 578
E++S EL L +++ EN+++L+ L + S+ +A+K ++ ++ L L D
Sbjct: 458 ELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD 517
Query: 579 N-----KLTELVSTINGLKEE-NNSLKSL--NDVITREKETQASELERSCQVIKQNGFEL 630
N +L IN LK++ N+L+ N RE E + E E+ VIK E
Sbjct: 518 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT-VIKPPVEEY 576
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKS-LLEQNLALKEQCEEKTRDCSRLEINIKTH 689
++MK+ EA+ +++ LK Q ++ D +
Sbjct: 577 EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEA--------- 627
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREA 748
E E NRMI L KQ+ E +L+ E + +L + Y K D + + ++ E
Sbjct: 628 EDMKEAMNRMIDELNKQVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHKAEHEK 683
Query: 749 VNQLT-TQKDLVEGRIAELESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ QLT + E ++E++S + E T T
Sbjct: 684 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 743
Query: 805 NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL---KERYKE----LDDE 857
+++ E K+ + + S + EV++L+++LL + + D + Y++ L+ E
Sbjct: 744 AKEMEE--KISNLKEHLAS--KEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE 799
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNL---KEQIRTQQPVERQA--KFADVAVNT 912
A L+E ++ ++ E + + +VS + KE I+T + Q +
Sbjct: 800 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA 859
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ A + S E +K+K++ + +E+ K+ L N+++++ + ++ +
Sbjct: 860 QEELAEMKR--YSESSSKLEEDKDKKINEMSKEVTKLKEAL-NSLSQLSYSTSSSKRQSQ 916
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL 998
+ EA +++++ + +L E K++++E+
Sbjct: 917 QLEALQQQVKQLQNQLAECKKQHQEV 942
Score = 41.5 bits (93), Expect = 0.016
Identities = 66/421 (15%), Positives = 192/421 (45%), Gaps = 28/421 (6%)
Query: 59 MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
+ SL +S+ + ++++++L L D++++ + E + + L +E Q+R + + + E+
Sbjct: 416 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEIS 475
Query: 119 NLTKD--KEIKNLTDSLKTKSKKINELQEENDT--LSNLIMENVTESDNLN---KEVDDL 171
+ D +++K + K++ +Q++ +S M+N + L +E++ L
Sbjct: 476 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVL 535
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
K++ + ++ ++ V E E K+ + K + + Y + + +N+
Sbjct: 536 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKE-- 593
Query: 232 DSNTSTRYNKICTLQSELDAGREDCK-ELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
+ + K Q E+ ++ K ++ ++ + ++ M +L++++ E ++
Sbjct: 594 ---KAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ 650
Query: 291 FETKAVKVMSEIKR--NLNSLSEQLIN---NESKKSKDHIDRYK-DSLLAVLDAEFGTTS 344
+A + + ++ +L ++ + I+ +E ++ R K + L+ + +++
Sbjct: 651 LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 710
Query: 345 LDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS-------LNS 396
++ ++ + + + + + E L+ T ++ E ++ ++ E LAS L
Sbjct: 711 NELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEK 770
Query: 397 QLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLD 456
QL+E++ A + + ++ S++ ++ ++LKE + KE K+ + I ++
Sbjct: 771 QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVS 829
Query: 457 Q 457
Q
Sbjct: 830 Q 830
Score = 36.7 bits (81), Expect = 0.46
Identities = 47/196 (23%), Positives = 92/196 (46%), Gaps = 12/196 (6%)
Query: 75 EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
EKL L + + S L K + + E + + QI+S E+ + ++KE N+ LK
Sbjct: 790 EKLQSSL---ESEVSVLASKLKESVKEKEKVHSEVVQIRS-EVSQVKREKE--NIQTLLK 843
Query: 135 TKSKKINELQEENDTLSNLIMENVTESDNLNK-EVDDLKKNNECLTQKCIDLEKLVNE-S 192
+K +++NEL ++ + E S++ +K E D KK NE ++++ L++ +N S
Sbjct: 844 SKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKDKKINE-MSKEVTKLKEALNSLS 902
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ + Q + E L Q + N L++ + + + R + + +Q ++D
Sbjct: 903 QLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDED 961
Query: 253 REDCKELCEDFTSIKN 268
+ K L + T KN
Sbjct: 962 VQ--KVLKQILTMCKN 975
>BC028423-1|AAH28423.1| 1022|Homo sapiens PMFBP1 protein protein.
Length = 1022
Score = 65.3 bits (152), Expect = 1e-09
Identities = 182/907 (20%), Positives = 369/907 (40%), Gaps = 106/907 (11%)
Query: 92 EGKYQNLILETQTRDLLMSQIKSLEME-NLTKDKEIKNLTDSLKTKSKKINELQEENDTL 150
E + L L + L +I SLE NL +DK +L++ ++ ++ LQ E +
Sbjct: 151 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSN-IELLECQVKMLQGELGGI 209
Query: 151 SNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKEN 210
EN + D+ + + C+ Q+ + +K ++E K+ ++ Q +L+
Sbjct: 210 MGQEPEN--KGDHSKVRI----YTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ-ELRNK 262
Query: 211 LIQS--LHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKN 268
L S L + + L KL + + RY + E + ++ K L E S
Sbjct: 263 LACSNALVLEREKALIKLQADFASCTATHRYPP--SSSEECEDIKKILKHLQEQKDSQCL 320
Query: 269 HLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRY 328
H+E ++ N+ DL +L +E + +K M +++ +L+ L E+ + HI+R
Sbjct: 321 HVEEYQ-NLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREE--------TSAHIER- 370
Query: 329 KDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVN 388
KD + +L L+ E K + D+ L++ ++ L+ +
Sbjct: 371 KDKDITILQCRLQELQLEFTET------QKLTLKKDKFLQEKDEM----------LQELE 414
Query: 389 EKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLK 448
+KL + + L++KE ++K++ +T+ K++ + ++ KLK
Sbjct: 415 KKLTQVQNSLLKKEK-----ELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLK 469
Query: 449 IDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
+ Q+ A + A + E + +E + +L+ G
Sbjct: 470 NSLEEAKQQERLAGEAPAAQ-QAAQCKEEAALAGCHLEDTQRKLQKGLL----------- 517
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
DT++E E++ L +E + K + L LSE + L+ + +
Sbjct: 518 -LDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKR 576
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLK-SLNDVI---TREKETQASELERSCQVIK 624
+ +++E+D K+ +++ I E S+K L + + T+ E + +L++S + K
Sbjct: 577 QLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 636
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
EL+ ++ + +E ++L + Q E + +
Sbjct: 637 LMEGELEALRQEF---KKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQ 693
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK-YEALKRDYDAAVKDLE 743
I+ K +Q +M LQ Q+ D L EK +T + Y+AL R A DL
Sbjct: 694 VIQDLNKEIALQKESLMSLQAQL--DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLT 751
Query: 744 SSREAVNQLTTQ-KDL------VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
+ E +N +T++ K L + + A+LE +I +
Sbjct: 752 QALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESEL 811
Query: 797 XXXTFGDENRDLG-ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELD 855
F + ++ + + + + +++ E E+L Q+E+ LKE E D
Sbjct: 812 EVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE-----EQLREFQEEMAALKENLLEDD 866
Query: 856 DE-C---------ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKF 905
E C +TC Y + D+ L E+ + +Q+V+N E++ Q + Q K+
Sbjct: 867 KEPCCLPQWSVPKDTCRLY-RGNDQIMTNL--EQWAKQQKVAN--EKLGNQ--LREQVKY 919
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
++ ++D +LHSV+V ++NK+L K IEE + K ++ + + +
Sbjct: 920 I-AKLSGEKD--HLHSVMVHLQ------QENKKLKKEIEEKKMKAENTRLCTKALGPSRT 970
Query: 966 KYTKKDK 972
+ T+++K
Sbjct: 971 ESTQREK 977
Score = 56.8 bits (131), Expect = 4e-07
Identities = 137/636 (21%), Positives = 264/636 (41%), Gaps = 72/636 (11%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEG 93
N ++E + IKLQ SC SS+E ++K+ L + K+ +
Sbjct: 267 NALVLEREKALIKLQADFA---SCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVE 323
Query: 94 KYQNLI---------LETQTRDLLMSQIK-SLEMENLTKD--KEIKNLTDSLKTKSKKIN 141
+YQNL+ + Q R+++ +K L++ L ++ I+ + ++
Sbjct: 324 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 383
Query: 142 ELQEENDTLSNLIMEN---VTESDNLNKEVDD---------LKKNNECLTQKCI--DLEK 187
ELQ E L ++ + E D + +E++ LKK E Q+C+ +LE
Sbjct: 384 ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM 443
Query: 188 LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQS 247
V E++ K+ A+CK + +Q L + +K ++ + + C ++
Sbjct: 444 TVKEAKQ---DKSKEAECKALQAEVQKLKNSLEE--AKQQERLAGEAPAAQQAAQCKEEA 498
Query: 248 EL-DAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
L ED + + L+ + + +L +L + + A K + ++ +
Sbjct: 499 ALAGCHLEDTQRKLQKGLL----LDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRV 554
Query: 307 NSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI--DLD 364
LS +L +E+ + ++ D+ K L + AE D+ + + + I L+
Sbjct: 555 EELSLEL--SEALRKLENSDKEKRQLQKTV-AEQDMKMNDMLDRIKHQHREQGSIKCKLE 611
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
E L++ TK+ D E + K +EKL + + +E + + + + E S +
Sbjct: 612 EDLQEATKLLEDKREQLKKSKE-HEKLMEGELEALRQE-----FKKKDKTLKENSRKLEE 665
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYE 484
+ EL+ T+ L+ S K + + + QDL +K+I + ++L++ ++ D
Sbjct: 666 ENENLRAELQCCSTQ--LESSLNKYNTSQQVIQDL--NKEIALQKESLMSLQ--AQLDKA 719
Query: 485 IEKEKLRLETGTAK----AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
++KEK L+T K A+ + L +E KSL + LT+ + K
Sbjct: 720 LQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKA 779
Query: 541 ---DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTEL-VSTINGLKEENN 596
+E A +K L+ E+ L+ ++E L + D KL E+ + K+ N
Sbjct: 780 QLEEEIIAYEERMKKLNTELRKLR---GFHQESELEVHAFDKKLEEMSCQVLQWQKQHQN 836
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
LK L KE Q E + +K+N E DK
Sbjct: 837 DLKML-----AAKEEQLREFQEEMAALKENLLEDDK 867
Score = 51.6 bits (118), Expect = 2e-05
Identities = 149/769 (19%), Positives = 293/769 (38%), Gaps = 82/769 (10%)
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE--------RIH 416
E ++ ++V +++ ++ + KLA N+ ++E+E A ++++Q + R
Sbjct: 237 ETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKA--LIKLQADFASCTATHRYP 294
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA--HKKITILFDALIT 474
SS DI K L+E +CL + + + ++ +DL +L A +K I+ D +
Sbjct: 295 PSSSEECEDIKKILKHLQEQKDSQCLHVEEYQ-NLVKDLRVELEAVSEQKRNIMKDMMKL 353
Query: 475 QYEL----SRTDYEIE-KEK-LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL 528
+ +L T IE K+K + + + + L+E ++ L
Sbjct: 354 ELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQEL 413
Query: 529 HEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL--TELVS 586
++LT++ S + + ++ ++ A ++ + E K E + K E+
Sbjct: 414 EKKLTQVQNSLLKKEK------ELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQK 467
Query: 587 TINGLKEENNSLKSLNDVITREKETQASE--------LERSCQVIKQNGFELDKMKADIL 638
N L+E + + ++ Q E LE + + + Q G LDK KAD +
Sbjct: 468 LKNSLEEAKQQERLAGEAPAAQQAAQCKEEAALAGCHLEDTQRKL-QKGLLLDKQKADTI 526
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
E ++A KEQ + R L + + + E ++
Sbjct: 527 QELQRELQMLQK------------ESSMAEKEQTSNRKR-VEELSLELSEALRKLENSDK 573
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK----RDYDAAVKDLESSREAVNQLTT 754
+LQK + E D + ++ + ++K D A K LE RE + +
Sbjct: 574 EKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKE 633
Query: 755 QKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKL 814
+ L+EG + L + + + T + + + K
Sbjct: 634 HEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN-----KY 688
Query: 815 DDSPKRSISVISD--SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY--LQERDE 870
+ S + VI D E++ KE L+S Q +LD ++ K T Y L +
Sbjct: 689 NTSQQ----VIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSA 744
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRTQ--QPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
C + L V++ + ++ Q E++A+ + + +E L++ +
Sbjct: 745 ACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 804
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+ E E + K +++ V + QK ++ K AK ++L + + E+
Sbjct: 805 FHQESELE------VHAFDKKLEEMSCQVLQWQK---QHQNDLKMLAAKEEQLREFQEEM 855
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQKVALEK---QIE 1044
LK+ E D+E C ++ C+ + +I + QKVA EK Q+
Sbjct: 856 AALKENLLEDDKE-PCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLR 914
Query: 1045 SLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
S S +V QQ +K+ + KKM A+ +C K
Sbjct: 915 EQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTK 963
Score = 44.8 bits (101), Expect = 0.002
Identities = 151/833 (18%), Positives = 340/833 (40%), Gaps = 89/833 (10%)
Query: 232 DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEF 291
D S+ +K+ +LQ ++ + CK + T N L + E M D+K + F
Sbjct: 9 DREVSSLNSKLLSLQLDIKNLHDVCKR--QRKTLQDNQLCMEEA-MNSSHDKKQAQALAF 65
Query: 292 ETKAVKVMSEIK---RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
E V+ S + R L L ++L+ + ++ + H + + S ++ +
Sbjct: 66 EESEVEFGSSKQCHLRQLQQLKKKLLVLQ-QELEFHTEELQTSYYSLRQYQ-SILEKQTS 123
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE-LKSVNEKLASLNSQLIEKENACNI 407
++++ + + ++ DE++ Y + G+ NE T E L E+LA ++ E + N+
Sbjct: 124 DLVL--LHHHCKLKEDEVI-LYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNL 180
Query: 408 LRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL---SKLKI-DIPRDLDQDLPAHK 463
R + + + + + EL I+ +E SK++I P + + K
Sbjct: 181 YRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 240
Query: 464 KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
+++ ++ + Q +L ++LR + + A+ F + H
Sbjct: 241 RLSEVWQKVSQQDDLI--------QELRNKLACSNALVLEREKALIKLQADFASCTATHR 292
Query: 524 EVKSLHEE---LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
S EE + K+ K ++ ++ ++ + L++ + E+ ++ KD
Sbjct: 293 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIM-KDMM 351
Query: 581 LTELVSTINGLKEENNSL-----KSLNDVITREKETQASELERSCQVIKQNGF--ELDKM 633
EL ++GL+EE ++ K + + R +E Q E +K++ F E D+M
Sbjct: 352 KLEL--DLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 409
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE-KT 692
++ E K QN LK++ E + + C E+ + E K
Sbjct: 410 LQEL-------------------EKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ 450
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
+ + LQ ++Q+ K +E+ + L + A ++ AA E++ +
Sbjct: 451 DKSKEAECKALQAEVQKL-KNSLEEAKQQERLAGEAPAAQQ---AAQCKEEAALAGCHLE 506
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
TQ+ L +G + + ++ T+ T NR E
Sbjct: 507 DTQRKLQKGLLLD------KQKADTIQELQRELQMLQKESSMAEKEQT---SNRKRVEEL 557
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYK-----------ELDDECETC 861
L+ S SD E QL++ + +++D+ +R K +L+++ +
Sbjct: 558 SLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEA 617
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
+ L+++ EQ + K+ + +E ++ L+++ + + ++ + + A L
Sbjct: 618 TKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKE-NSRKLEEENENLRAELQC 676
Query: 922 VVVDRMSYDAEVEKNKRLMKTI-EELRYKKQDLKNTVTKMQKAMEK-----YTKKDKE-F 974
S + ++++++ + +E+ +K+ L + ++ KA++K T KE +
Sbjct: 677 CSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAY 736
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
+A ++ C+ +L + ++ + E ++ + L Q +E+ +L+E IA E
Sbjct: 737 DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYE 789
Score = 41.1 bits (92), Expect = 0.021
Identities = 57/290 (19%), Positives = 126/290 (43%), Gaps = 27/290 (9%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+ +++Q++ LL ++EL+ + EL+ + A+ + ++ +C L+ E Q++
Sbjct: 414 EKKLTQVQNSLLKKEKELEKQQCMATELEMTVKE-AKQDKSKEAECKALQAEV----QKL 468
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
N E+ + Q+ + +A A A E+ A + D ++L K +
Sbjct: 469 KNSLEEAKQQERLAGEAPAAQQAAQCKEEAALAGCHLEDTQ---------RKLQKGLLLD 519
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE----C 1002
+ K ++ ++Q ++ + +KE + RK +E+ EL E ++ + D+E
Sbjct: 520 KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQ 579
Query: 1003 ETCAEYLKQREEQCKRLK-----EAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
+T AE + + R+K + I ++ + L LE + E L + M
Sbjct: 580 KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLME 639
Query: 1058 VATGSAIVQNQQITDVMKEN-QKLKKMNAKL---ITICKKRGKTGANREN 1103
+ + ++ +KEN +KL++ N L + C + ++ N+ N
Sbjct: 640 GELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYN 689
Score = 32.7 bits (71), Expect = 7.5
Identities = 30/157 (19%), Positives = 67/157 (42%), Gaps = 8/157 (5%)
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFA-DVAVNTDEDWANLHSVVVD 925
ERD + + L + LSL+ + NL + + Q+ + + + A+N+ D ++ +
Sbjct: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFE 66
Query: 926 RMSYDAEVEKN---KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL- 981
+ K ++L + ++L +Q+L+ ++Q + + E + +L
Sbjct: 67 ESEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLV 126
Query: 982 ---EDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
CK + +E+ +E+ E E L +EQ
Sbjct: 127 LLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQ 163
>AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein.
Length = 989
Score = 65.3 bits (152), Expect = 1e-09
Identities = 115/536 (21%), Positives = 227/536 (42%), Gaps = 43/536 (8%)
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I +L S +I +LQE L + + E L E+ + CL I
Sbjct: 426 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-- 483
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
+E+ + + K Q K +E + + L + L ++ D+ + ++++
Sbjct: 484 ----SENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYS--HFHELRVT 537
Query: 246 QSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGEN-NEFETKAVKVMSEIK 303
+ E++ ++D + E+ K + EL E + + + E+E S I+
Sbjct: 538 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 597
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL--MDNIINKYQI 361
N+N + + + +++++ I + KD+L + + E + D+ E + M + +NK
Sbjct: 598 -NMNK-EKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 655
Query: 362 DLDEI-------LEKYTKVQGDLNECTSEL--KSVNEKLASL-NSQLIEKENACNILRIQ 411
+L ++ LE Y K + L + T+E K+ +EKL L N + E+A + ++ Q
Sbjct: 656 ELSQLYKEAQAELEDYRK-RKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 714
Query: 412 KERI-HEISSAVTIDIVKKENELK-----EILT------KECL-KLSKLKIDIPRDLDQD 458
++ +E++ + +KEN + +++T KE K+S LK + + +
Sbjct: 715 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASK-EVE 773
Query: 459 LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
+ +K + A +T + R+ YE + L E + +
Sbjct: 774 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 833
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
++VK E + L KSK E N L + EE+ +K +++ K+ +KD
Sbjct: 834 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMK-RYSESSSKL--EEDKD 890
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
K+ E+ + LKE NSL L+ T + Q+ +LE Q +KQ +L + K
Sbjct: 891 KKINEMSKEVTKLKEALNSLSQLS-YSTSSSKRQSQQLEALQQQVKQLQNQLAECK 945
Score = 62.5 bits (145), Expect = 8e-09
Identities = 116/588 (19%), Positives = 252/588 (42%), Gaps = 55/588 (9%)
Query: 535 LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEE 594
L KS D N+ + ++ + +++ ++ ++ E K L + E ++ ELV N E
Sbjct: 429 LGKSTTD-NDVRIQQLQEILQDLQK-RLESSEAERKQLQV-ELQSRRAELVCLNNTEISE 485
Query: 595 NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXX 654
N+S D+ + KETQ+ E +V+ +MK ++
Sbjct: 486 NSS-----DLSQKLKETQSKYEEAMKEVLSVQ----KQMKLGLVSPESMDNYSHFHELRV 536
Query: 655 XDEAKSLLEQNL--ALKE--QCEEKTRDCSRLEIN------IKTH-EKTAEIQNRMIMRL 703
+E ++L+Q+L AL+E + +EK R+ + IK E+ E+++ +
Sbjct: 537 TEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 596
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD-LESSREAVNQLTTQKDLVEGR 762
+ +E LF + + E+ + LK D E +EA+N++ + +
Sbjct: 597 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 656
Query: 763 IAELESDIRTE-QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRS 821
+++L + + E + + +R E+ L + +
Sbjct: 657 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDA-LSEMKSQY 715
Query: 822 ISVISD-SEVSQL----KERLLSCQQELD---DLKERYKELDDECETCAEYLQERDEQCA 873
V+++ +++ QL KE +S + L L+ KE++++ E+L ++ + A
Sbjct: 716 SKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVA 775
Query: 874 RLKK----EKLSLEQQVSNLKEQIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMS 928
+L+K EK ++ + + Q +E + A + ++ +HS VV S
Sbjct: 776 KLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRS 835
Query: 929 YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
++V++ K ++T+ L+ K+Q++ + K Q+A E+ + + E+ K ED ++
Sbjct: 836 EVSQVKREKENIQTL--LKSKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKDKKI 893
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
E+ + +L E + ++ ++ ++ + + V +L NQ +KQ + +
Sbjct: 894 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV-- 951
Query: 1049 TPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGK 1096
+S M++ VQ Q DV QK+ K +++T+CK + +
Sbjct: 952 --ISVYRMHLLYA---VQGQMDEDV----QKVLK---QILTMCKNQSQ 987
Score = 58.8 bits (136), Expect = 1e-07
Identities = 106/506 (20%), Positives = 219/506 (43%), Gaps = 52/506 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLN--LIKILSEEIDALKIAIAKNEEKMLSL---SEKD 578
E++S EL L +++ EN+++L+ L + S+ +A+K ++ ++ L L D
Sbjct: 467 ELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD 526
Query: 579 N-----KLTELVSTINGLKEE-NNSLKSL--NDVITREKETQASELERSCQVIKQNGFEL 630
N +L IN LK++ N+L+ N RE E + E E+ VIK E
Sbjct: 527 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT-VIKPPVEEY 585
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKS-LLEQNLALKEQCEEKTRDCSRLEINIKTH 689
++MK+ EA+ +++ LK Q ++ D +
Sbjct: 586 EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEA--------- 636
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREA 748
E E NRMI L KQ+ E +L+ E + +L + Y K D + + ++ E
Sbjct: 637 EDMKEAMNRMIDELNKQVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHKAEHEK 692
Query: 749 VNQLT-TQKDLVEGRIAELESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ QLT + E ++E++S + E T T
Sbjct: 693 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 752
Query: 805 NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL---KERYKE----LDDE 857
+++ E K+ + + S + EV++L+++LL + + D + Y++ L+ E
Sbjct: 753 AKEMEE--KISNLKEHLAS--KEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE 808
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNL---KEQIRTQQPVERQA--KFADVAVNT 912
A L+E ++ ++ E + + +VS + KE I+T + Q +
Sbjct: 809 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA 868
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ A + S E +K+K++ + +E+ K+ L N+++++ + ++ +
Sbjct: 869 QEELAEMKR--YSESSSKLEEDKDKKINEMSKEVTKLKEAL-NSLSQLSYSTSSSKRQSQ 925
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL 998
+ EA +++++ + +L E K++++E+
Sbjct: 926 QLEALQQQVKQLQNQLAECKKQHQEV 951
Score = 41.5 bits (93), Expect = 0.016
Identities = 66/421 (15%), Positives = 192/421 (45%), Gaps = 28/421 (6%)
Query: 59 MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME 118
+ SL +S+ + ++++++L L D++++ + E + + L +E Q+R + + + E+
Sbjct: 425 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEIS 484
Query: 119 NLTKD--KEIKNLTDSLKTKSKKINELQEENDT--LSNLIMENVTESDNLN---KEVDDL 171
+ D +++K + K++ +Q++ +S M+N + L +E++ L
Sbjct: 485 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVL 544
Query: 172 KKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSIS 231
K++ + ++ ++ V E E K+ + K + + Y + + +N+
Sbjct: 545 KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKE-- 602
Query: 232 DSNTSTRYNKICTLQSELDAGREDCK-ELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
+ + K Q E+ ++ K ++ ++ + ++ M +L++++ E ++
Sbjct: 603 ---KAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQ 659
Query: 291 FETKAVKVMSEIKR--NLNSLSEQLIN---NESKKSKDHIDRYK-DSLLAVLDAEFGTTS 344
+A + + ++ +L ++ + I+ +E ++ R K + L+ + +++
Sbjct: 660 LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVL 719
Query: 345 LDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS-------LNS 396
++ ++ + + + + + E L+ T ++ E ++ ++ E LAS L
Sbjct: 720 NELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEK 779
Query: 397 QLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLD 456
QL+E++ A + + ++ S++ ++ ++LKE + KE K+ + I ++
Sbjct: 780 QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVS 838
Query: 457 Q 457
Q
Sbjct: 839 Q 839
Score = 36.7 bits (81), Expect = 0.46
Identities = 47/196 (23%), Positives = 92/196 (46%), Gaps = 12/196 (6%)
Query: 75 EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
EKL L + + S L K + + E + + QI+S E+ + ++KE N+ LK
Sbjct: 799 EKLQSSL---ESEVSVLASKLKESVKEKEKVHSEVVQIRS-EVSQVKREKE--NIQTLLK 852
Query: 135 TKSKKINELQEENDTLSNLIMENVTESDNLNK-EVDDLKKNNECLTQKCIDLEKLVNE-S 192
+K +++NEL ++ + E S++ +K E D KK NE ++++ L++ +N S
Sbjct: 853 SKEQEVNELLQKFQQAQEELAEMKRYSESSSKLEEDKDKKINE-MSKEVTKLKEALNSLS 911
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ + Q + E L Q + N L++ + + + R + + +Q ++D
Sbjct: 912 QLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDED 970
Query: 253 REDCKELCEDFTSIKN 268
+ K L + T KN
Sbjct: 971 VQ--KVLKQILTMCKN 984
>AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and
Golgi-localized PKN-associated protein (CG-NAP) protein.
Length = 3899
Score = 65.3 bits (152), Expect = 1e-09
Identities = 112/584 (19%), Positives = 249/584 (42%), Gaps = 53/584 (9%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
+++ E+ +++EQ + +N E Q L Q++ + E+ T+ +E++
Sbjct: 2190 IDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKESTTRLQELEQENKLF 2246
Query: 134 KTKSKKINELQEENDTLSN------------LIMENVTESDNLNKEVDDLKKNNECLTQK 181
K +K+ +E+D +S +I E E D LN++V L++ + T
Sbjct: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306
Query: 182 CIDLEK--LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ EK L+ + E +I +C +K N + + + + KL + +++ T
Sbjct: 2307 KVIEEKNELIRDLETQIECLMSDQEC-VKRNREEEIE-QLNEVIEKLQQELANIGQKTSM 2364
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
N +L E D+ + + + +++ +E MT + L E N + + +
Sbjct: 2365 NAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF-MKNVLKETNFKMNQLTQEL 2422
Query: 300 SEIKRNLNSLS--EQLINNESKKSKDHIDRYKDSLLAVL--DAEFGTTSLDVFEILMDN- 354
+KR S+ + + N + DH+ + K L VL DA + F+ +N
Sbjct: 2423 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2482
Query: 355 ---IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
IIN + L ++ + +L +C ++K + E+ +++++K+ N+ +I
Sbjct: 2483 KGSIIN-LETRLRQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKK-IVNLQKIV 2539
Query: 412 KERIHE-ISSAVTIDIVKKENEL---KEILTKECLKLSKLKIDIPRD--LDQDLPAHKKI 465
+E++ + S + ++ V++ + + ++ E + + ++ R+ L D+ A +
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA---L 2596
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTA-----KAVXXXXXXXXXXXXXXFDTLEE 520
T+ L +Q T +EKE++ + K + +
Sbjct: 2597 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2656
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE---- 576
+ +V+ L + T+L+ S +E + N ++ L E A K +A +EK L E
Sbjct: 2657 SPQDVEVL-KTTTELFHS--NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2713
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSC 620
K+ +T L ++ +++ K ++ +E ET+ E +++C
Sbjct: 2714 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2757
Score = 62.1 bits (144), Expect = 1e-08
Identities = 164/796 (20%), Positives = 323/796 (40%), Gaps = 68/796 (8%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK--EQKSAL 91
N IIE + ++L+D +T + K+ L+E + N +++ + EL + K E++S+
Sbjct: 335 NTKIIEEEKKTLELKDK--LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 92 EGKY-QNLILETQTRDLLMSQ-----IKSLEMENLTKDKEIKNLTDSL------KTKSKK 139
E K + E Q R+ SQ ++ +E E K ++++ D + + K +
Sbjct: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL 452
Query: 140 INE---LQEENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN- 194
I + EE T MEN S N+ D +K N + + I L+ ++ E
Sbjct: 453 IRQHMAQMEEIKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 512
Query: 195 --KIGP--KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD--SNTSTRYNKICT---L 245
++G + CA + E+L++ L + + ++I++ S + + + T L
Sbjct: 513 KEELGLILEEKCALQRQLEDLVEELSFSRGQ-IQRARQTIAEQESKLNEAHKSLSTVEDL 571
Query: 246 QSELDAGREDCKELC----EDFTSIKNHLELHEPNMTMDLDEKL-GENNEFETKAVKVMS 300
++E+ + E KEL + T+ K LE+ E LD + E E + +++
Sbjct: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQLLF 631
Query: 301 EIKRNLNSLSEQL-INNES--KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+ L+ L E L I + +K KD++ + + L E + ++ + DN+I
Sbjct: 632 SHEEELSKLKEDLEIEHRISIEKLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDNLIT 690
Query: 358 KYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
K + EI + Q +N + E+ +L L ++E L + + +
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT-----ILFDAL 472
+ + + +KEN+L+E + + S LK D + L+ L H ++ I D++
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILK-DEKKTLEDMLKIHTPVSQEERLIFLDSI 809
Query: 473 ITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHNEVK 526
++ + S + EIE E L+ + F+ +E E
Sbjct: 810 KSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYA 869
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVS 586
L + L SK + + +K L+EE++ +I + K E + E +
Sbjct: 870 CLLKVKDDLEDSKNKQELEYKSKLKALNEELNLQRINPTTVKMKSSVFDEDKTFVAETLE 929
Query: 587 TINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXX 646
++++ L +V REK + L + +KQ E+ + ++
Sbjct: 930 MGEVVEKDTTELMENLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV----KSLKQ 985
Query: 647 XXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
E + ++ N A Q C+ T++ S L+ + + AE + ++ K
Sbjct: 986 EKEQVSLRCRELEIIINHNRAEDVQSCD--TQESSLLDGVVTMTSRGAE---GSVSKVNK 1040
Query: 706 QIQEDDKLFIEKETKLNELT----NKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEG 761
E+ K+ +E + +T +K E L D+ +V ESS A K E
Sbjct: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRATQPSENDKLQKEL 1099
Query: 762 RIAELE-SDIRTEQTA 776
+ + E +D+R + A
Sbjct: 1100 NVLKSEQNDLRLQMEA 1115
Score = 61.3 bits (142), Expect = 2e-08
Identities = 153/819 (18%), Positives = 330/819 (40%), Gaps = 68/819 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ ++ + L + ++N T S S + LQ + L++ + + E D+L ++
Sbjct: 235 SQKLQIQFQQLQASETLRNSTHS----STAADLLQAKQQILTH--QQQLEEQDHL---LE 285
Query: 170 DLKKNNECLTQKCIDLEKLVN----ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
D +K E T + L++ + E + K+ N + + KE +I+ L+ + +
Sbjct: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNT---KIIEE 341
Query: 226 LNRSISDSNTSTRYNKIC-TLQSELDAGREDCKELCEDFTSIKN--HLELHEPNMTMDLD 282
+++ + T +K+ LQ ++ ++ K + + T+ K E M
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 401
Query: 283 EKLGENN----EFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
E+L + N +FET V+ M E +R L L +L + I + K L+
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHM 457
Query: 338 AEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ + M+N + Y I ++E K V +NE +L+ N + L
Sbjct: 458 AQMEEIKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKE 514
Query: 397 QL-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
+L + E C + R ++ + E+S S I ++ +E E K D+ +
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
+ + K++ + +A +T Y++ +EKEK + A++
Sbjct: 575 IVSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLST----- 627
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 628 -QLLFSHEEELSKLKEDLEIEHRISIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF- 683
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 684 -EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
Query: 635 ADI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTH 689
++ L ++ L +N LK+ E+KT D ++ +
Sbjct: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQE 800
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESS 745
E+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 746 REAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXX 798
+ + + L KD +E + E + +++ A +
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELNLQRINPTTVKMKSSVFDED 920
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
TF E ++GE + D + ++ E +L +RL ++ LK+++ E+
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMENLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLN 977
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ 897
E QE+++ R ++ ++ + + + TQ+
Sbjct: 978 EEVKSLKQEKEQVSLRCRELEIIINHNRAEDVQSCDTQE 1016
Score = 59.7 bits (138), Expect = 6e-08
Identities = 107/584 (18%), Positives = 251/584 (42%), Gaps = 46/584 (7%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLSEKDNKLTEL 584
S +E K+Y+ + D+ N N +I +E I+ L I + E+K L L +K +L
Sbjct: 299 SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 585 VSTING-LKEENNSLKSLNDVIT--REKETQASE----LERSCQVIKQNGFELDKMKADI 637
+ + + ++N +K++ +T ++KE Q+SE L + + +++ + + + DI
Sbjct: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ E + Q + +Q E + +++E IKT K E++N
Sbjct: 419 VQRMEQETQRKLEQLRA--ELDEMYGQQIVQMKQ-ELIRQHMAQME-EIKTRHK-GEMEN 473
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
+ + ED + +NEL K + E +E + + +K
Sbjct: 474 ALRSYSNITVNEDQIKLMN--VAINELNIKLQDTN-------SQKEKLKEELGLILEEKC 524
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
++ ++ +L ++ + T D ++ +
Sbjct: 525 ALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE---- 580
Query: 818 PKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETCA-EYLQERDEQCARL 875
++ + + ++EV+ K +L ++E + + +R E + E E + + L +E+ ++L
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKL 640
Query: 876 KKEKLSLEQQVS--NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
K E L +E ++S LK+ + + +++ + +++ + E+
Sbjct: 641 K-EDLEIEHRISIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEI 699
Query: 934 EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQ 993
K K L +++ + K +++ + ++QK +E +++KE +E+++ + + E L++
Sbjct: 700 SKLKDLQQSL--VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
Query: 994 RYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN 1053
+ KE + + + E Q E + LK+ K LE + K+ + V+ E+++ L + +
Sbjct: 758 QMKEKENDLQ---EKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSKS 813
Query: 1054 STMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
V ++I +++EN+ LK+ +L +K+ T
Sbjct: 814 KDS--------VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
Score = 59.7 bits (138), Expect = 6e-08
Identities = 148/772 (19%), Positives = 315/772 (40%), Gaps = 70/772 (9%)
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
E LM NI ++ Q ++++LE ++ L K +L + +K+ A L
Sbjct: 1840 EELMLNISSRLQAAVEKLLEAISETSSQLEHA----KVTQTEL--MRESFRQKQEATESL 1893
Query: 409 RIQ---KERIHEISSA---VTIDIVKKENELKEILTKECLKLSKL--KIDIPRDLDQDLP 460
+ Q +ER+HE S A + +++ K E + ++ L ++ K D+ L+Q+L
Sbjct: 1894 KCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDVIDRLEQELL 1953
Query: 461 AHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD---- 516
+A Q + R +KE ++ E G +
Sbjct: 1954 CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAE 2013
Query: 517 -TLEEAHNEVKSLH----EELTKLYKSKVDENNANLNLIK---ILSEEIDALKI-----A 563
++ +VK+L E++++ + + ++N ++L + L ++++ ++ A
Sbjct: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073
Query: 564 IAKNEEKMLSLSE--KDNKLTELVSTINGLKE-ENNSLKSLNDVITREKETQASEL---- 616
I + E+ + E K + ++V + E + ++ L + + +EK + SEL
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL-KEKTDKCSELLLSK 2132
Query: 617 ERSCQVIKQNGFELDKMKADI--LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
E+ + I++ E++K++ + L+ SL Q A ++ +
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVRELVQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2192
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
K ++ + LE ++ + E +N + +L Q++ K E T+L EL + + K D
Sbjct: 2193 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQELEQENKLFKDD 2249
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAEL--ESDIRTEQTATVXXXXXXXXXXXXXX 792
+ ++ S +A++ T + ++ G+ A++ E ++ +Q +
Sbjct: 2250 MEKLGLAIKES-DAMS--TQDQHVLFGKFAQIIQEKEVEIDQ---LNEQVTKLQQQLKIT 2303
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYK 852
+ RDL + S + + + E+ QL E + QQEL ++ ++
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363
Query: 853 ELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNT 912
+ +E Q + EKL+LEQQV E++ + V ++ F
Sbjct: 2364 M---NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF-----KM 2415
Query: 913 DEDWANLHSVVVDRMSYD--AEVEKNKRLMKTIEELRYKKQDLKNTVTK-MQKAMEKYTK 969
++ L S+ +R S + + +N + I+ L K +L+ +T+ K++E T
Sbjct: 2416 NQLTQELFSLKRERESVEKIQSIPENS-VNVAIDHLSKDKPELEVVLTEDALKSLENQT- 2473
Query: 970 KDKEFEAKRK-ELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
K FE K + + + L +L+ D E C + +K +EQ + + + +I
Sbjct: 2474 YFKSFEENGKGSIINLETRLRQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKKI 2532
Query: 1029 VD--KLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
V+ K+ +KVA + + V + I + T++ NQ
Sbjct: 2533 VNLQKIVEEKVA-AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2583
Score = 55.6 bits (128), Expect = 9e-07
Identities = 165/730 (22%), Positives = 307/730 (42%), Gaps = 65/730 (8%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 664 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 780
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
Query: 187 KLVNESEN--KIGPKNICAQC-KLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ + + N KN +L+E L + D SK + + + N+
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 244 TLQS-ELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
LQ + ED T + LE+ E + D E L EN E TK K+ E+
Sbjct: 901 NLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV-VEKDTTE-LMENLEV-TKREKL--EL 955
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI- 361
+ L+ LSEQL K K + + + L E SL E ++ IIN +
Sbjct: 956 SQRLSDLSEQL------KQKHGEISFLNEEVKSLKQEKEQVSLRCRE--LEIIINHNRAE 1007
Query: 362 DLDEILEKYTKVQGDLNECTS-----ELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
D+ + + + + TS + VN+ + ++E + + + + +E
Sbjct: 1008 DVQSCDTQESSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ 1067
Query: 417 EISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI--T 474
E + V KE+ L+ E KL K ++++ + DL + + +L+ T
Sbjct: 1068 EQLILDHLPSVTKESSLRATQPSENDKLQK-ELNVLKSEQNDLRLQMEAQRICLSLVYST 1126
Query: 475 QYELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHE 530
+ R E EK+K L+ E A+ +E +E K LH
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Query: 531 ELTKLYKSKVDENNANL-NLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTI 588
+ KL K+ +E + L L +L E ALK + +++ +N+ EL
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 589 NGLKEENNSLKSLNDVITRE------KETQASEL--ERSCQVIKQNGFE-LDKMKADILM 639
+++ ++ +L + +T E +T+ S++ +++ + + G E L K + + L
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ SL + + L+EQ +E S L+ +K E+ E +
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE-- 1364
Query: 699 MIMRLQKQIQ 708
I LQK++Q
Sbjct: 1365 -IHCLQKRLQ 1373
Score = 49.2 bits (112), Expect = 8e-05
Identities = 54/263 (20%), Positives = 125/263 (47%), Gaps = 18/263 (6%)
Query: 849 ERYKELDDECETCAEY-LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF 905
+R +E + + EY +Q++ Q ++ E S++ + + L+EQ+ +++ V E +++
Sbjct: 3101 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3160
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
A + + H + + ++ EV+ + + + + ++Q A+E
Sbjct: 3161 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEHKKSR---ELQWALE 3217
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQREEQCKRLKE 1021
K K + E ++ELED K LE KQR +L+ E+ + +Q+ E + L +
Sbjct: 3218 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYD 3277
Query: 1022 AKIA------LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVM 1074
A+++ LE+ L +QKV + + +L ++ + + G+ + D++
Sbjct: 3278 AQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 3337
Query: 1075 KENQK-LKKMNAKLITICKKRGK 1096
KE QK L++ +++++ + + K
Sbjct: 3338 KELQKQLEEKHSRIVELLNETEK 3360
Score = 48.4 bits (110), Expect = 1e-04
Identities = 108/523 (20%), Positives = 226/523 (43%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 364 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEIKTRHKGEMENAL-RSYSNI 481
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 542 GQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L+TQ E +++L+ D+ E ++
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKLKEDLEIEHRISIEKLKDNLGI 661
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 662 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 717
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 718 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 772
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 875
Score = 47.6 bits (108), Expect = 2e-04
Identities = 74/334 (22%), Positives = 141/334 (42%), Gaps = 19/334 (5%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT 121
S+K+ + E+ E+LS E + E KS L L + + + ++++ +E
Sbjct: 3134 SMKDRATELQ---EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3190
Query: 122 KDKEIKNLTDSLKTKSKKINELQ----EENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
K E+ L D+L ++ KK ELQ +E L + E ++L ++ K+ N
Sbjct: 3191 KTDEVHLLNDTLASEHKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3250
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L ++L+NES+ KI + + +L E ++L + K+ R S+T
Sbjct: 3251 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLQSQKV-RIREMSSTLD 3309
Query: 238 RYNKI-CTLQSELDAGREDCKELCED-FTSIKNHLELHEPNMTMDLDEKLGENNEFETKA 295
R ++ LQS G+ ED ++ LE + L+E E + ++
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET--EKYKLDSLQ 3367
Query: 296 VKVMSEIKRNLNS---LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLDVFEIL 351
+ E R ++ +EQ N E +K + + L L+ + LD+
Sbjct: 3368 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3427
Query: 352 MDNIINKYQ---IDLDEILEKYTKVQGDLNECTS 382
+ I+ ++Q ++ +E E + +LNE T+
Sbjct: 3428 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 3461
Score = 47.2 bits (107), Expect = 3e-04
Identities = 109/559 (19%), Positives = 212/559 (37%), Gaps = 38/559 (6%)
Query: 566 KNEEKMLSLSEKDNKLTE-LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
+NEE ML++S + E L+ I+ + K + RE Q E S + +
Sbjct: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L + DE K+L E+ Q +EKT RLE
Sbjct: 1898 ELRERLHEESRAREQLAVELSKAEGVIDGYADE-KTLFER------QIQEKTDVIDRLEQ 1950
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI-EKETKLNELTNKYEALKRDYDAAVKDLE 743
+ A + + + Q+QIQE+ +L +KE E + L ++ + +K+
Sbjct: 1951 ELLC----ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE-- 2004
Query: 744 SSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
E Q +D ++ ++ LE D+ + + + +
Sbjct: 2005 -KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
+ R + +D +R + E+ +L+++L + E E E A
Sbjct: 2064 KMRKFLDEQAIDREHERDVF---QQEIQKLEQQL-KVVPRFQPISEHQTR---EVEQLAN 2116
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQI-----RTQQPVERQAKFADVAVNTDEDWAN 918
+L+E+ ++C+ L K L++ + E+I R ++ V+ E
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELVQALLVEDRKHFGAVEAKPE 2176
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
L V + DA K K + E+L +++L+N ++Q+ + + KE +
Sbjct: 2177 LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2236
Query: 979 KELED----CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI--ALEIVDKL 1032
+ELE K ++E+L KE D L + Q + KE +I E V KL
Sbjct: 2237 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2296
Query: 1033 SNQ-KVALEKQIESLSNTPVSNSTMYV---ATGSAIVQNQQITDVMKENQKLKKMNAKLI 1088
Q K+ + ++ N + + + + V+ + ++ + N+ ++K+ +L
Sbjct: 2297 QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELA 2356
Query: 1089 TICKKRGKTGANRENEDPS 1107
I +K + E S
Sbjct: 2357 NIGQKTSMNAHSLSEEADS 2375
Score = 45.2 bits (102), Expect = 0.001
Identities = 88/419 (21%), Positives = 177/419 (42%), Gaps = 48/419 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLE----INIKTHEKTAE--IQ-NRMIMRLQKQIQE 709
E + + L L EQ ++ +L+ + TH TA +Q + I+ Q+Q++E
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D L + + K + T + L+ V ++E ++ N + E I EL +
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTK 337
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
I E+ T+ +N+++ +N KL+ + + S E
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEI-KNMKLELTNSKQKERQSSEE 393
Query: 830 VSQL--------KERLLSCQQELDDLKERYKELDDECETCAEYLQER-DEQCARLKKEKL 880
+ QL K Q E D ++ +E + E L E +Q ++K+E +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVA-VNTDEDWANLHSVVVDRMSY---DAEVEKN 936
Q ++ + E+I+T+ E + + + +ED L +V ++ ++ D +K
Sbjct: 454 --RQHMAQM-EEIKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
Query: 937 K---RLMKTIEE---LRYKKQDLKNTVT----KMQKAMEKYTKKDKEFEAKRKEL---ED 983
K L +EE L+ + +DL ++ ++Q+A + +++ + K L ED
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLNEAHKSLSTVED 570
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-NQKVALEK 1041
KAE+ + KEL+ + E K + E ++ K A ++D+++ +Q+ LE+
Sbjct: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA-----VLDRMAESQEAELER 624
Score = 44.4 bits (100), Expect = 0.002
Identities = 77/399 (19%), Positives = 190/399 (47%), Gaps = 28/399 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEI-- 126
E +++++L+ ++ +++Q L+ N ++E + L+ +++ ++E L D+E
Sbjct: 2281 EKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEKNE--LIRDLET-QIECLMSDQECVK 2334
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+N + ++ ++ I +LQ+E L+N+ + + +L++E D LK + + + + LE
Sbjct: 2335 RNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2391
Query: 187 KLV-NESENKIGPKNICAQCKLKEN-LIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ V +E KN+ + K N L Q L + + + +SI +++ + + +
Sbjct: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 2451
Query: 244 TLQSELDAG-REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ EL+ ED + E+ T K+ E + ++L+ +L + + +++
Sbjct: 2452 KDKPELEVVLTEDALKSLENQTYFKS-FEENGKGSIINLETRLRQLESTVSAKDLELTQC 2510
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYK---DSLLAVLDAEFGTTSLDVF-EILMDNIINK 358
+ + + EQ K ++ K + + A L ++ ++ + + DN
Sbjct: 2511 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 2570
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + I + +++ D E S++ ++ +++ L SQ++E + L ++KE++ EI
Sbjct: 2571 SEPERTNI-QNLNQLRED--ELGSDISALTLRISELESQVVEMHTS---LILEKEQV-EI 2623
Query: 419 SSAVTIDIVKKENELKEILT-KECLKLSKLKIDIPRDLD 456
+ ++ KK EL+++L E + K K P+D++
Sbjct: 2624 AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2662
Score = 44.0 bits (99), Expect = 0.003
Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 58/420 (13%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR---DLLMSQIKSLEMEN 119
+K E N K+ +L+ ELF +K ++ ++E K Q+ I E D L LE+
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVE-KIQS-IPENSVNVAIDHLSKDKPELEVV- 2460
Query: 120 LTKD--KEIKNLT--DSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKK- 173
LT+D K ++N T S + K I L+ L + + E K++ D+++
Sbjct: 2461 LTEDALKSLENQTYFKSFEENGKGSIINLETRLRQLESTVSAKDLELTQCYKQIKDMQEQ 2520
Query: 174 ---NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI 230
E L +K ++L+K+V E K+ L+ + + + + +
Sbjct: 2521 GQFETEMLQKKIVNLQKIVEE--------------KVAAALVSQIQL---EAVQEYAKFC 2563
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
D+ T + + +Q+ L+ RED EL D +++ + E + +++ L E
Sbjct: 2564 QDNQTISSEPERTNIQN-LNQLRED--ELGSDISALTLRISELE-SQVVEMHTSLILEKE 2619
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
A K + E ++ L L + L NE K+ R K+ + D E T+ ++F
Sbjct: 2620 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ------REKEKKRSPQDVEVLKTTTELFH- 2672
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
N + + +L+ + + + +EL S EK L +L+ KE N+ +
Sbjct: 2673 --SNEESGFFNELEALRAESVATK-------AELASYKEKAEKLQEELLVKET--NMTSL 2721
Query: 411 QKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
QK+ R H + + I++KE+E + +K+ L I + + + KI+
Sbjct: 2722 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2781
Score = 40.7 bits (91), Expect = 0.028
Identities = 66/282 (23%), Positives = 118/282 (41%), Gaps = 28/282 (9%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+E Q K++D + ++ S I L+ EK + EL D+++Q ALE + +
Sbjct: 2006 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK-NTELMDLRQQNQALEKQLEK 2064
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT--KSKKINELQ-EENDTLSNLI 154
+ R L Q E E +EI+ L LK + + I+E Q E + L+N +
Sbjct: 2065 M------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
E + L + L+++ + ++ LE V E Q L E+
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE----------LVQALLVED---R 2165
Query: 215 LHIGYDNTLSKLNRSI---SDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHL 270
H G +L+ + ++ + R K I L+ +L+ RE+ + E+ + L
Sbjct: 2166 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2225
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ + T L E EN F+ K+ IK + +++S Q
Sbjct: 2226 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMSTQ 2266
Score = 40.3 bits (90), Expect = 0.037
Identities = 77/380 (20%), Positives = 162/380 (42%), Gaps = 25/380 (6%)
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRM------IMRLQKQIQEDDKLFIE 716
+ + LK + E + LE NI+ + + E+Q + LQ+Q+ + + E
Sbjct: 3096 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3155
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+++L + + E + +K+LE+ R V T + L+ +A R Q A
Sbjct: 3156 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEHKKSRELQWA 3215
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+ F E++ N +L+ ++ ++++S+ +R
Sbjct: 3216 -LEKEKAKLGRSEERDKEELEDLKFSLESQKQ-RNLQLNLLLEQQKQLLNESQQKIESQR 3273
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+L Q L + + R EL ++ ++E R + +L + Q S+ Q R
Sbjct: 3274 MLYDAQ-LSEEQGRNLELQVLLQSQKVRIREMSSTLDR--ERELHAQLQSSDGTGQSRPP 3330
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKTIEELRYKKQDLKN 955
P E D+ + HS +V+ ++ E EK K ++T +++ +Q +
Sbjct: 3331 LPSE------DLLKELQKQLEEKHSRIVELLN---ETEKYKLDSLQTRQQMEKDRQVHRK 3381
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T+ Q+A + KK E ++K +ED + +LEE +Q+ +LD E + +++ ++Q
Sbjct: 3382 TLQTEQEANTEGQKKMHELQSK---VEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ 3438
Query: 1016 CKRLKEAKIALEIVDKLSNQ 1035
+E + + I+ + N+
Sbjct: 3439 ELEREEKRESRRILYQNLNE 3458
Score = 39.1 bits (87), Expect = 0.086
Identities = 95/517 (18%), Positives = 210/517 (40%), Gaps = 40/517 (7%)
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN--SLSEQLI 314
++L E + + LE + T + E + E T+++K E++ L+ S + + +
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-ATESLKCQEELRERLHEESRAREQL 1913
Query: 315 NNESKKSKDHIDRYKDS-LLAVLDAEFGTTSLDVFE---ILMDNIINKYQIDLDEILEKY 370
E K++ ID Y D L + T +D E + N + + + + +I E+
Sbjct: 1914 AVELSKAEGVIDGYADEKTLFERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQEER 1973
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEISSAVTIDIVK 428
+ +E V ++L +L+++ E C +++ + ++ A+ ID+ +
Sbjct: 1974 ELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVK-ALEIDVEE 2032
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
+ + E+ ++ +L L+ + L++ L +K D E R ++ E +
Sbjct: 2033 QVSRFIELEQEKNTELMDLRQQ-NQALEKQLEKMRKF---LDEQAIDREHERDVFQQEIQ 2088
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
KL + + L+E ++ L +L + + E N +
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD-IQERNEEIE 2147
Query: 549 LIKI-LSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR 607
++ + E + AL + K+ + + E ++ +L + + + + + +L + + +
Sbjct: 2148 KLEFRVRELVQALLVEDRKHFGAVEAKPELSLEV-QLQAERDAIDRKEKEITNLEEQLEQ 2206
Query: 608 EKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLA 667
+E ELE + ++Q +L+ K + D+ + L LA
Sbjct: 2207 FRE----ELENKNEEVQQLHMQLEIQKKE---STTRLQELEQENKLFKDDMEKL---GLA 2256
Query: 668 LKEQCEEKTRDCSRL--EINIKTHEKTAEIQ--NRMIMRLQKQ---------IQEDDKLF 714
+KE T+D L + EK EI N + +LQ+Q I+E ++L
Sbjct: 2257 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2316
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ 751
+ ET++ L + E +KR+ + ++ L E + Q
Sbjct: 2317 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2353
Score = 38.7 bits (86), Expect = 0.11
Identities = 106/547 (19%), Positives = 214/547 (39%), Gaps = 46/547 (8%)
Query: 484 EIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAH--NEVKSLHEELTKLYKSKVD 541
E+ + KL LET T KA D +E H N+ + + ++ + ++
Sbjct: 3159 ELAQTKLELET-TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEHKKSRELQWALE 3217
Query: 542 ENNANLNLIKILS-EEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+ A L + EE++ LK ++ +++ L L+ + +L +N +++ S +
Sbjct: 3218 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL---LNESQQKIESQRM 3274
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDK-MKADILMXXXXXXXXXXXXXXXXDEAK 659
L D E++ + EL+ Q K E+ + + + ++
Sbjct: 3275 LYDAQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3334
Query: 660 SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQI-----QEDDKLF 714
LL++ L++Q EEK L +N K +Q R M +Q+ Q + +
Sbjct: 3335 DLLKE---LQKQLEEKHSRIVEL-LNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN 3390
Query: 715 IEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
E + K++EL +K E L+R LE R+ V +L + ++G + E + +Q
Sbjct: 3391 TEGQKKMHELQSKVEDLQRQ-------LEEKRQQVYKLDLEGQRLQGIMQEFQ-----KQ 3438
Query: 775 TATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLK 834
D R+ K++ K S + +++ ++
Sbjct: 3439 ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKES----NYAKLIEMN 3494
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIR 894
C EL+ ++++ + + + + + ER Q E Q+ N+ E I
Sbjct: 3495 GGGTGCNHELEMIRQKLQCVASKLQVLPQKASER-LQFETADDEDFIWVQE--NIDEIIL 3551
Query: 895 TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLK 954
Q + Q V+ +L +R+ + +N L I +L +K DL+
Sbjct: 3552 QLQKLTGQQGEEPSLVSPSTSCGSL----TERL-----LRQNAELTGHISQLTEEKNDLR 3602
Query: 955 NTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL-DEECETCAEYLKQRE 1013
N V K+++ + Y + + + + A +E + KE+ + E T + LK+ E
Sbjct: 3603 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE 3662
Query: 1014 EQCKRLK 1020
+ +LK
Sbjct: 3663 AEVYKLK 3669
Score = 37.5 bits (83), Expect = 0.26
Identities = 47/221 (21%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE- 900
Q+L + + K+ D LQ+ + +E L L +Q L+ Q + Q E
Sbjct: 191 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250
Query: 901 -RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + A A+L +++ ++E+ L +E+ + KK+D ++
Sbjct: 251 LRNSTHSSTA-------ADLLQAKQQILTHQQQLEEQDHL---LEDYQKKKEDFTMQISF 300
Query: 960 MQKAMEKY-TKKDKEFEAKRKE--------LEDCKAELEELKQRYKELDEECETCAEYLK 1010
+Q+ ++ Y ++DK+ E KE +E+ ++ E +++ EL ++ T + L
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 1011 QREEQ-CKRLKEAK-IALEIVDKLSNQKVALEKQIESLSNT 1049
+ +EQ ++ +E K + LE+ + ++ + E +I+ L T
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSE-EIKQLMGT 400
>D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein.
Length = 1388
Score = 64.9 bits (151), Expect = 2e-09
Identities = 138/707 (19%), Positives = 285/707 (40%), Gaps = 60/707 (8%)
Query: 54 TISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIK 113
+++ ++ ++ KE EI L+ + + L ++ +K+ L+ K + D + +
Sbjct: 472 SVNTRLEKTAKELEEEITLR-KSVESALRQLEREKALLQHKNAEY---QRKADHEADKKR 527
Query: 114 SLEME-NLTKDK--EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
+LE + N KD+ ++K + + ++K+N+LQ + D + L+ + L K +
Sbjct: 528 NLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAE 587
Query: 171 LKKNNECLTQKCIDLEK---LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLN 227
K + L DL+ L+ ++ K+ + I Q L+ H ++ L
Sbjct: 588 SSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTH--GSEIINDLQ 645
Query: 228 RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD--EKL 285
I + KI + EL+ ++L E FT ++ E +MT L ++
Sbjct: 646 GRICGLEEDLKNGKILLAKVELEK-----RQLQERFTDLEKEKSNMEIDMTYQLKVIQQS 700
Query: 286 GENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL 345
E E E KA K K N + E + +S+ K+ + + E
Sbjct: 701 LEQEEAEHKATKARLADK---NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEA 757
Query: 346 DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ L+D + + Q ++E+L++ + D+ T +++ +K + L +
Sbjct: 758 EKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQV 817
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIP---RDLDQDLPAH 462
N L++ ++++ + ++ + E+K L K+ +L K + D ++L L A
Sbjct: 818 NTLKMSEKQLKQENNHLM--------EMKMNLEKQNAELRKERQDADGQMKELQDQLEAE 869
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAH 522
+ + L+ TQ + + E EK KL E K T ++
Sbjct: 870 QYFSTLYK---TQVRELKEECE-EKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE 925
Query: 523 NEVKSLHEE-LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
+S+ EE + L K K+ + L + ++++ K + + + + SL E + L
Sbjct: 926 QLARSIAEEQYSDLEKEKIMK---ELEIKEMMARH----KQELTEKDATIASLEETNRTL 978
Query: 582 TELVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
T V+ + KEE NN LK + + ++R K+ + S Q KQ L+
Sbjct: 979 TSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQ------------LLT 1026
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI--QNR 698
K +++ + +EK +E+ + + T ++ +
Sbjct: 1027 ERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQK 1086
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESS 745
+ +Q QI E+ ++ IE + L+ + E L+ A L+SS
Sbjct: 1087 ELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSS 1133
Score = 57.2 bits (132), Expect = 3e-07
Identities = 84/407 (20%), Positives = 173/407 (42%), Gaps = 32/407 (7%)
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+++Q+L +E+ E K +RL K +E E ++ + ++K++ E+ L + E
Sbjct: 696 VIQQSLE-QEEAEHKATK-ARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENL 753
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
L E + L D DL+ S++ +N+L QKD++ + L I E
Sbjct: 754 LLEAEKRCSLL----DC---DLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLT 806
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGE---NPKLDDSPKRSISVISDSEVSQLKERL 837
EN L E N + ++ R +D ++ +L+++L
Sbjct: 807 QNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL 866
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV---------SN 888
+ Q K + +EL +ECE + +E ++ L+ E+ SL Q+
Sbjct: 867 EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQ 926
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
L I +Q + + + + E A + ++ + A +E+ N+ L + L
Sbjct: 927 LARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLA 986
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC-- 1005
+K++L N + +Q+ + + KD+E A + + K L E + + +++ E
Sbjct: 987 NEKEELNNKLKDVQEQLSRL--KDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNR 1044
Query: 1006 AEYLKQREEQCKRLKE---AKIALEIV---DKLSNQKVALEKQIESL 1046
E +K+ + R KE K+ +E+ +KL+ Q + +K++ +
Sbjct: 1045 KEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEM 1091
Score = 48.0 bits (109), Expect = 2e-04
Identities = 128/727 (17%), Positives = 291/727 (40%), Gaps = 46/727 (6%)
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL 332
+ N+ + EN+ +++ + EI++ L +L E L N ++K+ +++ S+
Sbjct: 416 YRENLLLSDSPSCRENDSIQSRKNEESQEIQKKLYTLEEHLSNE--MQAKEELEQKCKSV 473
Query: 333 LAVLDAEFGTTSLDV-FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKL 391
L+ ++ +++ + + + + + K + Q + + +++ +
Sbjct: 474 NTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDV 533
Query: 392 ASLNSQLIEKENACNILRIQKERIHEISSAV--TIDIVKKENELKEILTKECLKLSKLKI 449
SL QL + + +I E+++++ + T +++ E++ L K + SK +I
Sbjct: 534 NSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSK-QI 592
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
++DL K + L + E +E E+ R T ++ +
Sbjct: 593 QQLESNNRDLQ-DKNCLLETAKLKLEKEFINLQSALESER-RDRTHGSEIINDLQGRICG 650
Query: 510 XXXXXFD---TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK 566
+ L + E + L E T L K K + +K++ + ++ + A+
Sbjct: 651 LEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEE---AE 707
Query: 567 NEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK-ETQASELERSCQVIKQ 625
++ L++K NK+ E + + K L + ++K E E E+ C ++
Sbjct: 708 HKATKARLADK-NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDC 766
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN 685
+ + + K + L+ E ++ ++ + + +T+ + L+++
Sbjct: 767 D-LKQSQQKINELLKQKDVLNEDVRNLTLKIEQET--QKRCLTQNDLKMQTQQVNTLKMS 823
Query: 686 IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA---LKRDYDAAVKDL 742
K ++ M M L+KQ E K + + ++ EL ++ EA Y V++L
Sbjct: 824 EKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVREL 883
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+ E +L K+L + + EL+ D R A +
Sbjct: 884 KEECEEKTKLG--KELQQKK-QELQ-DERDSLAAQLEITLTKADSEQLARSIAE------ 933
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
++ DL + + + + + E+++ + S ++ L L +E E
Sbjct: 934 EQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELN 993
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
L++ EQ +RLK E++S + ++Q+ T++ ++ QA VN + N
Sbjct: 994 NKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQA------VNKLAEIMNRKEP 1047
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
V + D +V + ++ E R +LK+ K+ + M KY K+ E +A+ E
Sbjct: 1048 V--KRGNDTDVRRKEK------ENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEES 1099
Query: 983 DCKAELE 989
+ EL+
Sbjct: 1100 QIRIELQ 1106
Score = 47.2 bits (107), Expect = 3e-04
Identities = 41/205 (20%), Positives = 103/205 (50%), Gaps = 21/205 (10%)
Query: 810 ENPKLDDSPK----RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
EN L DSP SI + E +++++L + ++ L + + +EL+ +C++ +
Sbjct: 418 ENLLLSDSPSCRENDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKS----V 473
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF-------ADVAVNTDEDW 916
R E+ A+ +E+++L + V + Q+ ++ + + A++ AD N + D
Sbjct: 474 NTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDV 533
Query: 917 ANLHSVVVD--RMSYDAEV--EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+L + D + + ++++ EK +L + ++E + +T +++K + +K+ +
Sbjct: 534 NSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQ 593
Query: 973 EFEAKRKELEDCKAELEELKQRYKE 997
+ E+ ++L+D LE K + ++
Sbjct: 594 QLESNNRDLQDKNCLLETAKLKLEK 618
Score = 45.6 bits (103), Expect = 0.001
Identities = 56/291 (19%), Positives = 114/291 (39%), Gaps = 25/291 (8%)
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQ-QELDDLKERYKELDDECETCAEYLQERDEQCA 873
+D ++ + +++ L + L Q Q+++ LK K+L E E ++Q A
Sbjct: 787 EDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNA 846
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQ---------------PVERQAKFADVAVNTDEDWAN 918
L+KE+ + Q+ L++Q+ +Q E + K ++ +
Sbjct: 847 ELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQD 906
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
+ ++ +++L ++I E +Y + K + K + E + +E K
Sbjct: 907 ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE-KEKIMKELEIKEMMARHKQELTEKD 965
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ + L L E E LK +EQ RLK+ +I+ + K
Sbjct: 966 ATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAI------KAQ 1019
Query: 1039 LEKQI--ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
EKQ+ E T N + V+ TDV ++ ++ +K++ +L
Sbjct: 1020 FEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMEL 1070
Score = 44.4 bits (100), Expect = 0.002
Identities = 73/432 (16%), Positives = 179/432 (41%), Gaps = 25/432 (5%)
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
I + +E++ EIQ ++ L++ + + + E E K + + E ++ + + +
Sbjct: 434 IQSRKNEESQEIQKKLYT-LEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRK 492
Query: 744 SSREAVNQLTTQKDLVEGRIAELE--SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
S A+ QL +K L++ + AE + +D ++ +
Sbjct: 493 SVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI 552
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
E + + + D + SD+ ++L++ +++ L+ ++L D+ C
Sbjct: 553 STEK--VNQLQRQLDETNALLRTESDT-AARLRKTQAESSKQIQQLESNNRDLQDK--NC 607
Query: 862 AEYLQERDEQCARLKKEKLSLEQQV-SNLKEQIRTQQPV-ERQAKFADVAVNTDEDWANL 919
L E + +L+KE ++L+ + S +++ + + + Q + + + L
Sbjct: 608 ---LLETAK--LKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILL 662
Query: 920 HSVVVDRMSY-----DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
V +++ D E EK+ + +L+ +Q L+ + + + K+K +
Sbjct: 663 AKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIY 722
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLS 1033
E+ + + E+E+ + L ++ E L + E++C L + K + + +++L
Sbjct: 723 ESIEEAKSEAMKEMEKKLLEERTLKQKVE---NLLLEAEKRCSLLDCDLKQSQQKINELL 779
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAI-VQNQQITDVMKENQKLKKMNAKLITICK 1092
QK L + + +L+ + T + + +Q QQ+ + ++LK+ N L+ +
Sbjct: 780 KQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKM 839
Query: 1093 KRGKTGANRENE 1104
K A E
Sbjct: 840 NLEKQNAELRKE 851
Score = 42.3 bits (95), Expect = 0.009
Identities = 124/669 (18%), Positives = 269/669 (40%), Gaps = 65/669 (9%)
Query: 287 ENNEFETKAVKVMSEIKRNL----NSLSEQLINNESKKSKDHIDRYK-DSLLAVLDAEFG 341
+N E++ KA + KRNL NSL +QL + + + I K + L LD
Sbjct: 511 KNAEYQRKADHEADK-KRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDE--- 566
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK 401
T +L E + K Q + + +++ DL + L++ KL + I
Sbjct: 567 TNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKL---EKEFINL 623
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
++A R ++R H S + D+ + L+E L + L+K++++ R L +
Sbjct: 624 QSALESER--RDRTH--GSEIINDLQGRICGLEEDLKNGKILLAKVELE-KRQLQERFTD 678
Query: 462 HKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
+K + +T Y+L +E+E+ + A+ ++++EEA
Sbjct: 679 LEKEKSNMEIDMT-YQLKVIQQSLEQEEAEHKATKARLADKNKI---------YESIEEA 728
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
+E ++ E KL + + + NL+ + L + ++++K+ L ++ + L
Sbjct: 729 KSE--AMKEMEKKLLEERTLKQKVE-NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVL 785
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E V + E+ + L + + Q + L+ S + +KQ L +MK
Sbjct: 786 NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMK------- 838
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+L +QN L+++ ++ L+ ++ + + + +
Sbjct: 839 -----------------MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR 881
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVE 760
L+++ +E KL E + K EL ++ ++L + + +S + A + Q DL +
Sbjct: 882 ELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEK 941
Query: 761 GRI---AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
+I E++ + + +E +L N KL D
Sbjct: 942 EKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEEL--NNKLKD- 998
Query: 818 PKRSISVISDSEVSQLKERLLSCQQELDD--LK-ERYKELDDECETCAEYLQERDEQCAR 874
+ +S + D E+S + +Q L + LK + +L + + D R
Sbjct: 999 VQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRR 1058
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
+KE L ++ + +E++ TQQ ++ Q + ++ E+ + + S D+++E
Sbjct: 1059 KEKENRKLHMELKSEREKL-TQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1117
Query: 935 KNKRLMKTI 943
+ + ++ +
Sbjct: 1118 QLRSQLQAL 1126
>AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein.
Length = 2069
Score = 64.9 bits (151), Expect = 2e-09
Identities = 132/716 (18%), Positives = 269/716 (37%), Gaps = 36/716 (5%)
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
++ S+ +KL + +L + ++ C+ + + R+H S V + +KE ELK T+
Sbjct: 442 AKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRS 501
Query: 442 LKLSKLKI------DIPRDLDQ-----DLPAHKKITILFDALITQ---YELSRTDYEIEK 487
L L + R L+Q K + +L D E+ +Y+ +
Sbjct: 502 LLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQV 561
Query: 488 EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT-KLYKSKVDENNAN 546
E++RL + A E K E KL K+K D+
Sbjct: 562 EEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAK-DQGKPE 620
Query: 547 LNLIKILSEEIDA-LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
+ L E+I+A ++ I + +EK+ + + TEL+ I KE + + L +
Sbjct: 621 VGEYAKL-EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE--RAERELEKLQ 677
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
RE ++ + + ++ L+ + + + + ++
Sbjct: 678 NREDSSEG--IRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKI 735
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELT 725
L L+E+ E LE+++K E+ E I L QI++D +KET L
Sbjct: 736 LELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLDNQIKKD---LADKET----LE 785
Query: 726 NKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXX 785
N + + + K L + +N + ++ +E RI EL + +++
Sbjct: 786 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMK 845
Query: 786 XXXXXXXXXXXXXXTFGDENRDL-GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
+ L +N KL++ ++ IS S+ ++L E ++
Sbjct: 846 AQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK-ISHQDHSDKNRLLELETRLREVS 904
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK 904
+ +E+ EL + LQER+ Q L+ + +LE Q+ K ++ + E + +
Sbjct: 905 LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE-ETTAEAEEE 963
Query: 905 FADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM 964
+ + DE ++ E+ +L + EL + L + + A
Sbjct: 964 IQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 1023
Query: 965 EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKI 1024
++ + E + R+E+ + + +L KQ + L C E + E L E +
Sbjct: 1024 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKER 1083
Query: 1025 ALEI-VDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
E L ++K E ++ L + I +++Q+ ++ + K
Sbjct: 1084 QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHK 1139
Score = 54.4 bits (125), Expect = 2e-06
Identities = 179/979 (18%), Positives = 378/979 (38%), Gaps = 77/979 (7%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
++ S+E + L K KE+++ D +++ L + ++ + E +
Sbjct: 442 AKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRS 501
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICA----------QCKLKENLIQSLHIGY 219
L+++ +C L++ + ++ ++ ++ A KL+E Q
Sbjct: 502 LLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQV 561
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTM 279
+ +N+ D ++ R + + +SEL R +E T ++ L +
Sbjct: 562 EEMRLMMNQLEEDLVSARRRSDL--YESELRESRLAAEEFKRKATECQHKLLKAKDQGKP 619
Query: 280 DLDE--KLGE-NNEFETKAVKVMSEIKRNLNSLSE--QLINNESKKSKDHIDRYKDSLLA 334
++ E KL + N E + K ++ ++++ + + +E +L+ N +++K+ +R + L
Sbjct: 620 EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQN-IRQAKERAERELEKLQN 678
Query: 335 VLDAEFGTTS-LDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
D+ G L E ++ NK + L+ + + +++ D+ + +++ + +K+
Sbjct: 679 REDSSEGIRKKLVEAEERRHSLENKVK-RLETMERRENRLKDDIQTKSQQIQQMADKILE 737
Query: 394 LNSQLIEKENACNILRI---QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKID 450
L + E + + L + QKE+ +E V + +KK+ KE L + + +
Sbjct: 738 LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLEN----MMQRHEE 793
Query: 451 IPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG--TAKAVXXXXXXXX 508
+ + L K + D+ I E + E KL + T + +
Sbjct: 794 EAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEEMIS 852
Query: 509 XXXXXXFDTLEEAHN---EVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDALKI 562
F +A + + L E+L K+ + N L L ++ +S E + K+
Sbjct: 853 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKL 912
Query: 563 AIAKN-EEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQ 621
+ + E LSL E++++LT L + L+ + K+ E E +E E Q
Sbjct: 913 ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT-------ELEETTAEAEEEIQ 965
Query: 622 VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSR 681
+ + E+ + + ++ L QN L +Q +E +
Sbjct: 966 ALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDE 1025
Query: 682 L-EINIKTHEKTAEIQNR-MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
+ ++ + EI R M + QKQ E K T L E EAL +
Sbjct: 1026 IVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC---TMLEEQVMDLEALNDELLEKE 1082
Query: 740 KDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+ E+ R + +K E R+ EL+ + TE+ +
Sbjct: 1083 RQWEAWRSVLGD---EKSQFECRVRELQRMLDTEKQSRARADQRIT-------------- 1125
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
E+R + E + K I + + + + K + S +L+DL++++ L+
Sbjct: 1126 ----ESRQVVELAVKEH--KAEILALQQA-LKEQKLKAESLSDKLNDLEKKHAMLEMNAR 1178
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWAN 918
+ + L+ E RL +E+ L+QQ+ K I R Q ++ AD+ D
Sbjct: 1179 SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE- 1237
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK- 977
+ + ++ Y E K + + +L Q + K +K + K+D +
Sbjct: 1238 -YQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQV 1296
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKV 1037
+ + K LE+ K R EL+E + L+ E+ K + Q++
Sbjct: 1297 PLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQI 1356
Query: 1038 ALEKQIESLSNTPVSNSTM 1056
A+ + S + P + S +
Sbjct: 1357 AMSAIVRSPEHQPSAMSLL 1375
Score = 51.6 bits (118), Expect = 2e-05
Identities = 111/577 (19%), Positives = 245/577 (42%), Gaps = 44/577 (7%)
Query: 73 KLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDS 132
KLEK++ E +K Q+ L+ K + + + L+ I+ + + ++++N DS
Sbjct: 626 KLEKINAEQ-QLKIQE--LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDS 682
Query: 133 LKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ---KCIDLEKLV 189
+ KK+ E +E +L N + T N+ DD++ ++ + Q K ++LE+
Sbjct: 683 SEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE-- 740
Query: 190 NESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK-LNRSISDSNTSTRYNKICTLQSE 248
E ++ +++ K KE + DN + K L + N R+ + + +
Sbjct: 741 KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGK 800
Query: 249 -LDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNL 306
L + + S++ + EL E N + + L + + +++SE+++
Sbjct: 801 ILSEQKAMINAMDSKIRSLEQRIVELSEAN-KLAANSSLFTQRNMKAQE-EMISELRQQK 858
Query: 307 NSLSEQLINNESKKSK--------DHIDRYKDSLLAVLDAEFGTTSLDVFE--ILMDNII 356
L Q E++ K H D + L L+ SL+ E + + +
Sbjct: 859 FYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQL 918
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER-I 415
+ Q+ L E + T +Q S+L+ +L ++ E+ A R + +R
Sbjct: 919 TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKF 978
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ 475
+ ++ T+ I E +L + LT++ +L+ + + LD+ A+ +I L +
Sbjct: 979 DALRNSCTV-ITDLEEQLNQ-LTEDNAELNNQNFYLSKQLDEASGANDEIVQL------R 1030
Query: 476 YELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKL 535
E+ EI + +++L T + + D EA N+ E +
Sbjct: 1031 SEVDHLRREITEREMQL-TSQKQTMEALKTTCTMLEEQVMDL--EALNDELLEKERQWEA 1087
Query: 536 YKSKVDENNANLNL-IKILSEEIDALKIAIAKNEEK------MLSLSEKDNKLTELVSTI 588
++S + + + ++ L +D K + A+ +++ ++ L+ K++K E+++
Sbjct: 1088 WRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHK-AEILALQ 1146
Query: 589 NGLKEENNSLKSLNDVITREKETQASELERSCQVIKQ 625
LKE+ +SL+D + + E + + LE + + ++Q
Sbjct: 1147 QALKEQKLKAESLSDKL-NDLEKKHAMLEMNARSLQQ 1182
Score = 46.8 bits (106), Expect = 4e-04
Identities = 56/277 (20%), Positives = 119/277 (42%), Gaps = 21/277 (7%)
Query: 830 VSQLKERLLSCQQELD----DLKERY---KELDDECETCAEYLQERDEQCARLKKEKLSL 882
++QL+E L+S ++ D +L+E +E + C L + +Q E L
Sbjct: 568 MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKL 627
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR---- 938
E+ N ++Q++ Q+ E+ K + E N+ +R + E +N+
Sbjct: 628 EK--INAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAK-ERAERELEKLQNREDSSE 684
Query: 939 -LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
+ K + E ++ L+N V +++ + + + + K ++++ ++ EL+++++E
Sbjct: 685 GIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHRE 744
Query: 998 LDEECETCAEYLKQRE---EQCKRLKEAKIALEIVDK--LSNQKVALEKQIESLSNTPVS 1052
+ +LKQ+E E+ ++ + +I ++ DK L N E++
Sbjct: 745 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSE 804
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
M A S I +Q + E KL N+ L T
Sbjct: 805 QKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFT 840
Score = 44.8 bits (101), Expect = 0.002
Identities = 64/298 (21%), Positives = 130/298 (43%), Gaps = 24/298 (8%)
Query: 56 SCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL 115
SC + L+E N++ +L+ + F + +Q G ++ D L +I
Sbjct: 984 SCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER 1043
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
EM+ LT K+ ++LKT + E + + L++ ++E + + + D K
Sbjct: 1044 EMQ-LTSQKQ---TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF 1099
Query: 176 ECLT---QKCIDLEKLVN-ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLN-RSI 230
EC Q+ +D EK ++ +I + +KE+ + L + KL S+
Sbjct: 1100 ECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL 1159
Query: 231 SDS-NTSTRYNKIC-----TLQSELDAGREDCKELCEDFTSIKNHLEL---HEPNMTMDL 281
SD N + + + +LQ +L+ RE + L E+ ++ ++L H +T L
Sbjct: 1160 SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 1219
Query: 282 DEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAE 339
E L + +T+ S+++ L ++ + L ++E K + I + + L+ L A+
Sbjct: 1220 QEALDRADLLKTE----RSDLEYQLENI-QVLYSHEKVKMEGTISQ-QTKLIDFLQAK 1271
Score = 37.5 bits (83), Expect = 0.26
Identities = 44/223 (19%), Positives = 95/223 (42%), Gaps = 16/223 (7%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
LK E+ L L++ +L ++ ++ALE + + +T+ + + ++ +
Sbjct: 914 LKRQLTELQLSLQERESQLTALQAARAALESQLRQA--KTELEETTAEAEEEIQALTAHR 971
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
D EI+ D+L+ I +L+E+ + L+ E ++ L+K++D+ N+ + Q
Sbjct: 972 D-EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 1030
Query: 183 IDLEKL---VNESENKIGPKN-----ICAQCKLKENLIQSLHIGYDNTLSKLN-----RS 229
+++ L + E E ++ + + C + E + L D L K RS
Sbjct: 1031 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRS 1090
Query: 230 ISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLEL 272
+ S ++ LQ LD ++ + T + +EL
Sbjct: 1091 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 1133
Score = 33.5 bits (73), Expect = 4.3
Identities = 102/546 (18%), Positives = 217/546 (39%), Gaps = 43/546 (7%)
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN---LTKDKEIKNLTDS-LKTKSKKI 140
+E+ L+ + + + + +T + +M + + E L++ K + N DS +++ ++I
Sbjct: 764 EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 823
Query: 141 NELQEENDTLSN---LIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIG 197
EL E N +N N+ + + E+ K E K + + E KI
Sbjct: 824 VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 883
Query: 198 PKNICAQCKLKE--NLIQSLHIGYDNTLSKLNRSISDSNTST--RYNKICTLQSELDAGR 253
++ + +L E ++ + + ++ +L R +++ S R +++ LQ+ A
Sbjct: 884 HQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALE 943
Query: 254 EDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
++ + E +T DE + + + V+++++ LN L+E
Sbjct: 944 SQLRQAKTELEETTAEAEEEIQALTAHRDE-IQRKFDALRNSCTVITDLEEQLNQLTEDN 1002
Query: 314 --INNES---KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEIL 367
+NN++ K D D ++ L +E ++ E M K ++ L
Sbjct: 1003 AELNNQNFYLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTSQKQTMEALKTTC 1061
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENA--CNILRIQK------------- 412
+ DL EL + + S L ++++ C + +Q+
Sbjct: 1062 TMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD 1121
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDL-PAHKKITI---- 467
+RI E S +++ KE++ + + ++ LK KLK + D DL H + +
Sbjct: 1122 QRITE--SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARS 1179
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L L T+ EL + E E+ KL+ + K D L+ ++++
Sbjct: 1180 LQQKLETERELKQRLLE-EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 1238
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS 586
E + LY + + ++ L + + A AK ++ + S ++D L T++
Sbjct: 1239 QLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL 1298
Query: 587 TINGLK 592
N LK
Sbjct: 1299 QYNELK 1304
>AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein.
Length = 1428
Score = 64.9 bits (151), Expect = 2e-09
Identities = 138/707 (19%), Positives = 285/707 (40%), Gaps = 60/707 (8%)
Query: 54 TISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIK 113
+++ ++ ++ KE EI L+ + + L ++ +K+ L+ K + D + +
Sbjct: 512 SVNTRLEKTAKELEEEITLR-KSVESALRQLEREKALLQHKNAEY---QRKADHEADKKR 567
Query: 114 SLEME-NLTKDK--EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDD 170
+LE + N KD+ ++K + + ++K+N+LQ + D + L+ + L K +
Sbjct: 568 NLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAE 627
Query: 171 LKKNNECLTQKCIDLEK---LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLN 227
K + L DL+ L+ ++ K+ + I Q L+ H ++ L
Sbjct: 628 SSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTH--GSEIINDLQ 685
Query: 228 RSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD--EKL 285
I + KI + EL+ ++L E FT ++ E +MT L ++
Sbjct: 686 GRICGLEEDLKNGKILLAKVELEK-----RQLQERFTDLEKEKSNMEIDMTYQLKVIQQS 740
Query: 286 GENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL 345
E E E KA K K N + E + +S+ K+ + + E
Sbjct: 741 LEQEEAEHKATKARLADK---NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEA 797
Query: 346 DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ L+D + + Q ++E+L++ + D+ T +++ +K + L +
Sbjct: 798 EKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQV 857
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIP---RDLDQDLPAH 462
N L++ ++++ + ++ + E+K L K+ +L K + D ++L L A
Sbjct: 858 NTLKMSEKQLKQENNHLM--------EMKMNLEKQNAELRKERQDADGQMKELQDQLEAE 909
Query: 463 KKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAH 522
+ + L+ TQ + + E EK KL E K T ++
Sbjct: 910 QYFSTLYK---TQVRELKEECE-EKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSE 965
Query: 523 NEVKSLHEE-LTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
+S+ EE + L K K+ + L + ++++ K + + + + SL E + L
Sbjct: 966 QLARSIAEEQYSDLEKEKIMK---ELEIKEMMARH----KQELTEKDATIASLEETNRTL 1018
Query: 582 TELVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMX 640
T V+ + KEE NN LK + + ++R K+ + S Q KQ L+
Sbjct: 1019 TSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQ------------LLT 1066
Query: 641 XXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI--QNR 698
K +++ + +EK +E+ + + T ++ +
Sbjct: 1067 ERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQK 1126
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESS 745
+ +Q QI E+ ++ IE + L+ + E L+ A L+SS
Sbjct: 1127 ELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSS 1173
Score = 57.2 bits (132), Expect = 3e-07
Identities = 84/407 (20%), Positives = 173/407 (42%), Gaps = 32/407 (7%)
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+++Q+L +E+ E K +RL K +E E ++ + ++K++ E+ L + E
Sbjct: 736 VIQQSLE-QEEAEHKATK-ARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENL 793
Query: 721 LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
L E + L D DL+ S++ +N+L QKD++ + L I E
Sbjct: 794 LLEAEKRCSLL----DC---DLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLT 846
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGE---NPKLDDSPKRSISVISDSEVSQLKERL 837
EN L E N + ++ R +D ++ +L+++L
Sbjct: 847 QNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL 906
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV---------SN 888
+ Q K + +EL +ECE + +E ++ L+ E+ SL Q+
Sbjct: 907 EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQ 966
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELR 947
L I +Q + + + + E A + ++ + A +E+ N+ L + L
Sbjct: 967 LARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLA 1026
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETC-- 1005
+K++L N + +Q+ + + KD+E A + + K L E + + +++ E
Sbjct: 1027 NEKEELNNKLKDVQEQLSRL--KDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNR 1084
Query: 1006 AEYLKQREEQCKRLKE---AKIALEIV---DKLSNQKVALEKQIESL 1046
E +K+ + R KE K+ +E+ +KL+ Q + +K++ +
Sbjct: 1085 KEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEM 1131
Score = 48.0 bits (109), Expect = 2e-04
Identities = 128/727 (17%), Positives = 291/727 (40%), Gaps = 46/727 (6%)
Query: 273 HEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSL 332
+ N+ + EN+ +++ + EI++ L +L E L N ++K+ +++ S+
Sbjct: 456 YRENLLLSDSPSCRENDSIQSRKNEESQEIQKKLYTLEEHLSNE--MQAKEELEQKCKSV 513
Query: 333 LAVLDAEFGTTSLDV-FEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKL 391
L+ ++ +++ + + + + + K + Q + + +++ +
Sbjct: 514 NTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDV 573
Query: 392 ASLNSQLIEKENACNILRIQKERIHEISSAV--TIDIVKKENELKEILTKECLKLSKLKI 449
SL QL + + +I E+++++ + T +++ E++ L K + SK +I
Sbjct: 574 NSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSK-QI 632
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
++DL K + L + E +E E+ R T ++ +
Sbjct: 633 QQLESNNRDLQ-DKNCLLETAKLKLEKEFINLQSALESER-RDRTHGSEIINDLQGRICG 690
Query: 510 XXXXXFD---TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAK 566
+ L + E + L E T L K K + +K++ + ++ + A+
Sbjct: 691 LEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEE---AE 747
Query: 567 NEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREK-ETQASELERSCQVIKQ 625
++ L++K NK+ E + + K L + ++K E E E+ C ++
Sbjct: 748 HKATKARLADK-NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDC 806
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN 685
+ + + K + L+ E ++ ++ + + +T+ + L+++
Sbjct: 807 D-LKQSQQKINELLKQKDVLNEDVRNLTLKIEQET--QKRCLTQNDLKMQTQQVNTLKMS 863
Query: 686 IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEA---LKRDYDAAVKDL 742
K ++ M M L+KQ E K + + ++ EL ++ EA Y V++L
Sbjct: 864 EKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVREL 923
Query: 743 ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+ E +L K+L + + EL+ D R A +
Sbjct: 924 KEECEEKTKLG--KELQQKK-QELQ-DERDSLAAQLEITLTKADSEQLARSIAE------ 973
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
++ DL + + + + + E+++ + S ++ L L +E E
Sbjct: 974 EQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELN 1033
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
L++ EQ +RLK E++S + ++Q+ T++ ++ QA VN + N
Sbjct: 1034 NKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQA------VNKLAEIMNRKEP 1087
Query: 923 VVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
V + D +V + ++ E R +LK+ K+ + M KY K+ E +A+ E
Sbjct: 1088 V--KRGNDTDVRRKEK------ENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEES 1139
Query: 983 DCKAELE 989
+ EL+
Sbjct: 1140 QIRIELQ 1146
Score = 47.2 bits (107), Expect = 3e-04
Identities = 41/205 (20%), Positives = 103/205 (50%), Gaps = 21/205 (10%)
Query: 810 ENPKLDDSPK----RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYL 865
EN L DSP SI + E +++++L + ++ L + + +EL+ +C++ +
Sbjct: 458 ENLLLSDSPSCRENDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKS----V 513
Query: 866 QERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF-------ADVAVNTDEDW 916
R E+ A+ +E+++L + V + Q+ ++ + + A++ AD N + D
Sbjct: 514 NTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDV 573
Query: 917 ANLHSVVVD--RMSYDAEV--EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
+L + D + + ++++ EK +L + ++E + +T +++K + +K+ +
Sbjct: 574 NSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQ 633
Query: 973 EFEAKRKELEDCKAELEELKQRYKE 997
+ E+ ++L+D LE K + ++
Sbjct: 634 QLESNNRDLQDKNCLLETAKLKLEK 658
Score = 45.6 bits (103), Expect = 0.001
Identities = 56/291 (19%), Positives = 114/291 (39%), Gaps = 25/291 (8%)
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQ-QELDDLKERYKELDDECETCAEYLQERDEQCA 873
+D ++ + +++ L + L Q Q+++ LK K+L E E ++Q A
Sbjct: 827 EDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNA 886
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQ---------------PVERQAKFADVAVNTDEDWAN 918
L+KE+ + Q+ L++Q+ +Q E + K ++ +
Sbjct: 887 ELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQD 946
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
+ ++ +++L ++I E +Y + K + K + E + +E K
Sbjct: 947 ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE-KEKIMKELEIKEMMARHKQELTEKD 1005
Query: 979 KELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVA 1038
+ + L L E E LK +EQ RLK+ +I+ + K
Sbjct: 1006 ATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAI------KAQ 1059
Query: 1039 LEKQI--ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
EKQ+ E T N + V+ TDV ++ ++ +K++ +L
Sbjct: 1060 FEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMEL 1110
Score = 44.4 bits (100), Expect = 0.002
Identities = 73/432 (16%), Positives = 179/432 (41%), Gaps = 25/432 (5%)
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
I + +E++ EIQ ++ L++ + + + E E K + + E ++ + + +
Sbjct: 474 IQSRKNEESQEIQKKLYT-LEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRK 532
Query: 744 SSREAVNQLTTQKDLVEGRIAELE--SDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
S A+ QL +K L++ + AE + +D ++ +
Sbjct: 533 SVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI 592
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
E + + + D + SD+ ++L++ +++ L+ ++L D+ C
Sbjct: 593 STEK--VNQLQRQLDETNALLRTESDT-AARLRKTQAESSKQIQQLESNNRDLQDK--NC 647
Query: 862 AEYLQERDEQCARLKKEKLSLEQQV-SNLKEQIRTQQPV-ERQAKFADVAVNTDEDWANL 919
L E + +L+KE ++L+ + S +++ + + + Q + + + L
Sbjct: 648 ---LLETAK--LKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILL 702
Query: 920 HSVVVDRMSY-----DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
V +++ D E EK+ + +L+ +Q L+ + + + K+K +
Sbjct: 703 AKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIY 762
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLK-EAKIALEIVDKLS 1033
E+ + + E+E+ + L ++ E L + E++C L + K + + +++L
Sbjct: 763 ESIEEAKSEAMKEMEKKLLEERTLKQKVE---NLLLEAEKRCSLLDCDLKQSQQKINELL 819
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAI-VQNQQITDVMKENQKLKKMNAKLITICK 1092
QK L + + +L+ + T + + +Q QQ+ + ++LK+ N L+ +
Sbjct: 820 KQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKM 879
Query: 1093 KRGKTGANRENE 1104
K A E
Sbjct: 880 NLEKQNAELRKE 891
Score = 42.3 bits (95), Expect = 0.009
Identities = 124/669 (18%), Positives = 269/669 (40%), Gaps = 65/669 (9%)
Query: 287 ENNEFETKAVKVMSEIKRNL----NSLSEQLINNESKKSKDHIDRYK-DSLLAVLDAEFG 341
+N E++ KA + KRNL NSL +QL + + + I K + L LD
Sbjct: 551 KNAEYQRKADHEADK-KRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDE--- 606
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK 401
T +L E + K Q + + +++ DL + L++ KL + I
Sbjct: 607 TNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKL---EKEFINL 663
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
++A R ++R H S + D+ + L+E L + L+K++++ R L +
Sbjct: 664 QSALESER--RDRTH--GSEIINDLQGRICGLEEDLKNGKILLAKVELE-KRQLQERFTD 718
Query: 462 HKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
+K + +T Y+L +E+E+ + A+ ++++EEA
Sbjct: 719 LEKEKSNMEIDMT-YQLKVIQQSLEQEEAEHKATKARLADKNKI---------YESIEEA 768
Query: 522 HNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
+E ++ E KL + + + NL+ + L + ++++K+ L ++ + L
Sbjct: 769 KSE--AMKEMEKKLLEERTLKQKVE-NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVL 825
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXX 641
E V + E+ + L + + Q + L+ S + +KQ L +MK
Sbjct: 826 NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMK------- 878
Query: 642 XXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
+L +QN L+++ ++ L+ ++ + + + +
Sbjct: 879 -----------------MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR 921
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVE 760
L+++ +E KL E + K EL ++ ++L + + +S + A + Q DL +
Sbjct: 922 ELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEK 981
Query: 761 GRI---AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
+I E++ + + +E +L N KL D
Sbjct: 982 EKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEEL--NNKLKD- 1038
Query: 818 PKRSISVISDSEVSQLKERLLSCQQELDD--LK-ERYKELDDECETCAEYLQERDEQCAR 874
+ +S + D E+S + +Q L + LK + +L + + D R
Sbjct: 1039 VQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRR 1098
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE 934
+KE L ++ + +E++ TQQ ++ Q + ++ E+ + + S D+++E
Sbjct: 1099 KEKENRKLHMELKSEREKL-TQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1157
Query: 935 KNKRLMKTI 943
+ + ++ +
Sbjct: 1158 QLRSQLQAL 1166
>BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein.
Length = 2002
Score = 64.5 bits (150), Expect = 2e-09
Identities = 136/707 (19%), Positives = 289/707 (40%), Gaps = 44/707 (6%)
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+IK+ K + + L T R L+ Q+ ++ N KD+EI+ L L+ K+ NE
Sbjct: 1224 NIKKNKGVKDWPWWKLF--TTVRPLIEVQLSEEQIRN--KDEEIQQLRSKLEKAEKERNE 1279
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L+ +D L + I E +E + + + + T + + EK + E + + +
Sbjct: 1280 LRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDA--LK 1337
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSELDAGREDCKELCE 261
Q ++ E + + +++N + D + + K E+D + K L +
Sbjct: 1338 KQMEVMEMEVMEARL---IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTK---KRLQQ 1391
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
+F ++ LE+ + N L+ +LG+ ++ + + ++K+ L+ +L + +
Sbjct: 1392 EF---EDKLEVEQQN-KRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLE 1447
Query: 322 KDHIDRYK-DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC 380
+ ++ + D+E + + K Q + D +L + ++ L E
Sbjct: 1448 GQQVRNHELEKKQRRFDSELSQAHEEAQREKLQR--EKLQREKDMLLAEAFSLKQQLEEK 1505
Query: 381 TSELKSVNEKLASLNSQL-----IEKENACNILRIQKERIHEISSAVTIDIVKKENELKE 435
++ +K+ SL ++L E ++ ++ +++K+ + ++ + V + + +
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQ-LRDLEAKVKDQEEELDEQAGT 1564
Query: 436 ILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETG 495
I E LK +++++ + D+ +K + +++R D+E EK +LR +
Sbjct: 1565 IQMLEQLKQMEVQLEEEYE-DKQKVLREKRELEGKLATLSDQVNRRDFESEK-RLRKDLK 1622
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
KA+ + E ++K+ EE + V A I+ L
Sbjct: 1623 RTKALLADAQLMLDHLKNSAPSKREI-AQLKNQLEESEFTCAAAVKARKAMEVEIEDLHL 1681
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE---TQ 612
+ID + A EE++ L + N E+ + + +E+ N L + + Q
Sbjct: 1682 QIDDIAKAKTALEEQLSRLQREKN---EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1738
Query: 613 ASELERSCQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAK-SLLEQNLAL-K 669
++L+ + + EL +K++A EAK LE L +
Sbjct: 1739 INDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFER 1798
Query: 670 EQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETK--LNELTN 726
Q + SRL+ N+ EK E +++ I ++ +++ +L + ++TK + EL
Sbjct: 1799 TQVKRLESLASRLKENM---EKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR 1855
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
K R DLES A L L RI +L++ I E
Sbjct: 1856 KEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDE 1902
Score = 62.1 bits (144), Expect = 1e-08
Identities = 124/618 (20%), Positives = 259/618 (41%), Gaps = 77/618 (12%)
Query: 550 IKILSEEIDALKIAIAKNE----EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
I+ EEI L+ + K E E L+ +++++EL S + + S L D
Sbjct: 1256 IRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAE 1315
Query: 606 TREK---ETQASELERSCQVIKQNG--FELDKMKADILMXXXXXXXXXXXXXXXX----- 655
T E+ E + EL+ +K+ E++ M+A ++
Sbjct: 1316 TAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKY 1375
Query: 656 -------DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQ 708
D K L+Q K + E++ + +LE + + +E R + +L+K+ Q
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNK--RQLERRLGDLQADSEESQRALQQLKKKCQ 1433
Query: 709 ------EDDKLFIE-KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV-- 759
+D KL +E ++ + +EL K + A ++ + + +L +KD++
Sbjct: 1434 RLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLA 1493
Query: 760 -----EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKL 814
+ ++ E + DI V + RDL K
Sbjct: 1494 EAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVK- 1552
Query: 815 DDSPKRSISVISDSEVSQLKERLLSCQQELDD----LKERYKELDDECETCAEYLQERD- 869
D + + + QLK+ + ++E +D L+E+ +EL+ + T ++ + RD
Sbjct: 1553 DQEEELDEQAGTIQMLEQLKQMEVQLEEEYEDKQKVLREK-RELEGKLATLSDQVNRRDF 1611
Query: 870 EQCARLKKEKLSLEQQVSNLK---EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
E RL+K+ + +++ + + ++ P +R+ A + +E + V R
Sbjct: 1612 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKRE--IAQLKNQLEESEFTCAAAVKAR 1669
Query: 927 MSYDAEVE----------KNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+ + E+E K K L + + L+ +K +++N + + Q+ M + KK K
Sbjct: 1670 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAV 1729
Query: 976 AKRK----ELEDCKAELEELKQRYKELDEECETC---AEYLKQR--EEQCKRLKEAKIAL 1026
A+ ++ D +A+LEE + +EL E+ + E+L+Q ++ +EAKI
Sbjct: 1730 AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR- 1788
Query: 1027 EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAK 1086
E+ +L ++ + K++ESL++ N ++Q+I +E ++ K++ +
Sbjct: 1789 ELETRLEFERTQV-KRLESLASRLKENMEKLTEE-----RDQRIAAENREKEQNKRLQRQ 1842
Query: 1087 LITICKKRGKTGANRENE 1104
L ++ G+ A +E E
Sbjct: 1843 LRDTKEEMGEL-ARKEAE 1859
Score = 54.0 bits (124), Expect = 3e-06
Identities = 136/698 (19%), Positives = 279/698 (39%), Gaps = 42/698 (6%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
+ K + + +E+ +++ ++E TSEL S SQL++ E A LR +KE +
Sbjct: 1270 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA-SQLLDAETA-ERLRAEKE-M 1326
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ 475
E+ + D +KK+ E+ E+ E + +I+ ++D D A + + ++ + +
Sbjct: 1327 KELQTQY--DALKKQMEVMEMEVMEARLIRAAEIN--GEVDDD-DAGGEWRLKYERAVRE 1381
Query: 476 YELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL-- 532
+ ++ + E ++KL +E + + L++ + + L EL
Sbjct: 1382 VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 1441
Query: 533 TKLYKSKVDENNANLNLI--KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
TKL+ N L + SE A + A + ++ EKD L E S
Sbjct: 1442 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1501
Query: 591 LKEENNSLKSLND-VITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
L+E++ + V++ E E Q + S Q K L K+K +
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQ----DISSQESKDEA-SLAKVKKQLRDLEAKVKDQEE 1556
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
+ +LEQ ++ Q EE+ D ++ EK E++ ++ L Q+
Sbjct: 1557 ELDEQAGTIQ-MLEQLKQMEVQLEEEYEDKQKV-----LREKR-ELEGKLAT-LSDQVNR 1608
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D E E +L + + +AL D + L++S + ++ K+ +E +
Sbjct: 1609 RD---FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAA 1665
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
++ + V R+ E + + ++ +
Sbjct: 1666 VKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKH 1725
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK---EKLSLEQQV 886
+ + + Q ++DL+ + +E + E + E LQ Q L++ +K + +Q
Sbjct: 1726 KAAVAQASRDLAQ-INDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQE 1784
Query: 887 SNLKEQIRTQQPVER-QAK-FADVAVNTDEDWANLHSVVVDRMSYD-AEVEKNKRLMKTI 943
+ ++E + T+ ER Q K +A E+ L R++ + E E+NKRL +
Sbjct: 1785 AKIRE-LETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQR-- 1841
Query: 944 EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECE 1003
+LR K+++ K +A K + + + E+ + +A+L+ +R +L E
Sbjct: 1842 -QLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIE 1900
Query: 1004 TCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E + E+ ++ + E+ D++ K L K
Sbjct: 1901 DEME-SDENEDLINSEGDSDVDSELEDRVDGVKSWLSK 1937
Score = 47.6 bits (108), Expect = 2e-04
Identities = 82/403 (20%), Positives = 172/403 (42%), Gaps = 31/403 (7%)
Query: 662 LEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
+++N +K+ K R I ++ E+ ++ I +L+ ++++ +K E +L
Sbjct: 1225 IKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKE--RNELRL 1282
Query: 722 NELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXX 781
N +++ E+ + + + D ++ E+ +QL + R + +++T+ A
Sbjct: 1283 N--SDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM 1340
Query: 782 XXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLSC 840
++ D G +L + R + + +++L
Sbjct: 1341 EVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVE 1400
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE----KLSLE-QQVSNL---KEQ 892
QQ L+ R +L + E LQ+ ++C RL E KL LE QQV N K+Q
Sbjct: 1401 QQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQ 1460
Query: 893 IRTQQPVERQAKFAD-VAVNTDEDWANLHSVVVDRMSYDAEVEKNKR----LMKTIEELR 947
R + + + A + ++ ++ + S ++E+ + + L
Sbjct: 1461 RRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLE 1520
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE-------LEELKQRYKELDE 1000
+ QD+ + +K + ++ K K+ ++ EAK K+ E+ E LE+LKQ +L+E
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQLKQMEVQLEE 1580
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
E E KQ+ + KR E K+A + D+++ + EK++
Sbjct: 1581 EYED-----KQKVLREKRELEGKLA-TLSDQVNRRDFESEKRL 1617
Score = 35.9 bits (79), Expect = 0.80
Identities = 87/448 (19%), Positives = 189/448 (42%), Gaps = 29/448 (6%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI-KSLEMENLTKDKEIK 127
++ K ++L+ EL D K + + L + + D +SQ + + E L ++K ++
Sbjct: 1427 QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK-LQ 1485
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC----LTQKCI 183
D L ++ + + EE D + V + +++ + +E + ++
Sbjct: 1486 REKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1545
Query: 184 DLEKLVNESENKIGPKNICAQC--KLKENLIQSLHIGYDNTLSKLNRSIS-DSNTSTRYN 240
DLE V + E ++ + Q +LK+ +Q L Y++ L + +T +
Sbjct: 1546 DLEAKVKDQEEELDEQAGTIQMLEQLKQMEVQ-LEEEYEDKQKVLREKRELEGKLATLSD 1604
Query: 241 KICTLQSELDAG-REDCKE---LCEDFTSIKNHLELHEPNM--TMDLDEKLGENNEFETK 294
++ E + R+D K L D + +HL+ P+ L +L E+
Sbjct: 1605 QVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA 1664
Query: 295 AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
AVK ++ + L Q+ ++ K+K ++ L + L+ + M+
Sbjct: 1665 AVKARKAMEVEIEDLHLQI--DDIAKAKTALEEQLSRLQR--EKNEIQNRLEEDQEDMNE 1720
Query: 355 IINKYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC---NIL 408
++ K++ + + L + +Q L E E + + EKL +L SQ+ E + +++
Sbjct: 1721 LMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLV 1780
Query: 409 RIQKERIHEISSAVTID--IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI- 465
Q+ +I E+ + + + VK+ L L + KL++ + +++ +K++
Sbjct: 1781 SRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQ 1840
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLE 493
L D EL+R + E ++K LE
Sbjct: 1841 RQLRDTKEEMGELARKEAEASRKKHELE 1868
>AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protein
130d protein.
Length = 1135
Score = 64.5 bits (150), Expect = 2e-09
Identities = 113/535 (21%), Positives = 220/535 (41%), Gaps = 59/535 (11%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKML--- 572
+E V +L EELTKL VDE + + ++I L + K+
Sbjct: 219 QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
Query: 573 -SLSEKDNKLTEL-----VSTINGLKEENNSLKSLN--DVITREKETQASELERSCQVIK 624
+ E++ K T L T ++++ + L D R+ + + + L R ++
Sbjct: 279 ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L K + ++ E + L ++ L ++ + EE
Sbjct: 339 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL--------- 389
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDYDAAVK 740
IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++ +
Sbjct: 390 -IKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 741 DLESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 447 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKLKTLTV 498
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K D E
Sbjct: 499 MFVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSKTDVEE 555
Query: 860 TCAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
+ERD+ +LK E+ L +V+ LK ++++ + +E+ + ++ +
Sbjct: 556 KMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 615
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
LH E K K L + +E L+ K +D+K + K ++Y ++ +
Sbjct: 616 TALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 977 KRKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 719
Score = 58.0 bits (134), Expect = 2e-07
Identities = 136/657 (20%), Positives = 268/657 (40%), Gaps = 59/657 (8%)
Query: 107 LLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
LL+++ KS L ++E + + ++ + I L++E + L LI + + + +
Sbjct: 161 LLVAE-KSHRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
E + K L ++ L+ ++ + + AQ L+ IQ L T +KL
Sbjct: 220 EKE---KRVTTLKEELTKLKSFALMVVDE--QQRLTAQLTLQRQKIQELTTNAKETHTKL 274
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++++ K L+ EL + +D +I L +E + L +KL
Sbjct: 275 --ALAEARVQEEEQKATRLEKELQT---QTTKFHQDQDTIMAKLT-NEDSQNRQLQQKLA 328
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+ + + + E R+L E+L + + K SK Y ++ + E LD
Sbjct: 329 ALS----RQIDELEETNRSLRKAEEELQDIKEKISKGE---YGNAGIMAEVEELRKRVLD 381
Query: 347 VFEILMDNIINKYQI-DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ + I + Q DL++ LE+ T D +L L L + + C
Sbjct: 382 MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQEC 441
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI 465
L+ E+ + ++ ++ + +KE+ E +L K + L +DL K +
Sbjct: 442 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES-RLEKTEFT----LKEDLTKLKTL 496
Query: 466 TILF-DALITQYE-LSRTDYEIE--KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
T++F D T E L +T+ +++ +L++E V +EE
Sbjct: 497 TVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 556
Query: 522 HNEVKSLHEELTKLYKSKVDENN---ANLNLIKILSEEIDALKIAIAKNE------EKML 572
V ++L K++ ++ N + +N++K + ++A++ KN+ +
Sbjct: 557 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 616
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+L +++NK+ EL + LK + +K++ D + + E + LER + ++
Sbjct: 617 ALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLERR--------YANER 667
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE-KTRDCSRL--EINIKTH 689
KA L ++ ++ EQ L + Q EE K+ SR + K H
Sbjct: 668 DKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIH 727
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
E A +I LQ D ++K KLN+ N+ L R+ + K+LE R
Sbjct: 728 EYMAT--EDLICHLQ-----GDHSVLQK--KLNQQENRNRDLGREIENLTKELERYR 775
Score = 49.6 bits (113), Expect = 6e-05
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 826 SDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYL----QERDEQCARLKKEKL 880
S E Q KE R+ + ++EL LK + DE + L Q+ E K+
Sbjct: 213 SQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
L + ++E+ + +E++ + + D+D D + + +K L
Sbjct: 273 KLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-QKLAALS 331
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
+ I+EL + L+ ++Q EK +K + E+E+ + + +++ + +EL +
Sbjct: 332 RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E C + K+ E + + K+ K+ V+KLS + +ALEK
Sbjct: 392 MEEQCRDLNKRLERETLQSKDFKLE---VEKLSKRIMALEK 429
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/293 (20%), Positives = 132/293 (45%), Gaps = 28/293 (9%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE- 878
+S +++ E +L +L +Q++ +L KE + +QE +++ RL+KE
Sbjct: 236 KSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL 295
Query: 879 -----KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE-DWAN--LHSVVVDRMSYD 930
K +Q K Q + Q K A ++ DE + N L +
Sbjct: 296 QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 355
Query: 931 AEVEK----NKRLMKTIEELRYKKQDLKNT---VTKMQ-------KAMEKYTKKDKEFEA 976
++ K N +M +EELR + D++ + KM+ K +E+ T + K+F+
Sbjct: 356 EKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL 415
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ ++L LE+L+ + + +EC + L++ K+L + +L++ K +
Sbjct: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK---EL 472
Query: 1037 VALEKQIESLSNTPVSNST-MYVATGSAIVQNQQITDVMKENQ-KLKKMNAKL 1087
A+E ++E T + T + T + + + +++ +K+ + KL+ +++L
Sbjct: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
Score = 38.7 bits (86), Expect = 0.11
Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 26/227 (11%)
Query: 865 LQERDEQCARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
LQ RDE LK EK+ L E Q + + + + ++R A F + ED ++
Sbjct: 83 LQARDEVIGILKAEKMDLALLEAQYGFVTPK-KVLEALQRDA-FQAKSTPWQED---IYE 137
Query: 922 VVVDRMSYDAEVEKNKRLMKTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
++ + D VEK+K + I +L ++ + T+ ++++ EK +K KE+ K E
Sbjct: 138 KPMNEL--DKVVEKHKESYRRILGQLLVAEKSHRQTILELEE--EK--RKHKEYMEKSDE 191
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-----AKIALEIVD---KL 1032
C E +E ++ K +D+E ++ E +++E++ LKE AL +VD +L
Sbjct: 192 FI-CLLE-QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
Query: 1033 SNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ Q ++I+ L +N +++ + +A + Q+ T + KE Q
Sbjct: 250 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQ 296
Score = 36.3 bits (80), Expect = 0.61
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 14/188 (7%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQIRT-QQ 897
EL++ K ++KE ++ + E++ +++C RLKK E S E++ ++++ T ++
Sbjct: 174 ELEEEKRKHKEYMEKSD---EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ + FA + V DE + + R K + + Q+ +
Sbjct: 231 ELTKLKSFALMVV--DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 958 TKMQKAMEKYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQRE 1013
T+++K ++ T K ++ + +L + ++ +L+Q+ L +E E L++ E
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 1014 EQCKRLKE 1021
E+ + +KE
Sbjct: 349 EELQDIKE 356
>AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein.
Length = 3908
Score = 64.5 bits (150), Expect = 2e-09
Identities = 112/584 (19%), Positives = 249/584 (42%), Gaps = 53/584 (9%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
+++ E+ +++EQ + +N E Q L Q++ + E+ T+ +E++
Sbjct: 2199 IDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKESTTRLQELEQENKLF 2255
Query: 134 KTKSKKINELQEENDTLSN------------LIMENVTESDNLNKEVDDLKKNNECLTQK 181
K +K+ +E+D +S +I E E D LN++V L++ + T
Sbjct: 2256 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2315
Query: 182 CIDLEK--LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ EK L+ + E +I +C +K N + + + + KL + +++ T
Sbjct: 2316 KVIEEKNELIRDLETQIECLMSDQEC-VKRNREEEIE-QLNEVIEKLQQELANIGQKTSM 2373
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
N +L E D+ + + + +++ +E MT + L E N + + +
Sbjct: 2374 NAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF-MKNVLKETNFKMNQLTQEL 2431
Query: 300 SEIKRNLNSLS--EQLINNESKKSKDHIDRYKDSLLAVL--DAEFGTTSLDVFEILMDN- 354
+KR S+ + + N + DH+ + K L VL DA + F+ +N
Sbjct: 2432 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2491
Query: 355 ---IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
IIN + L ++ + +L +C ++K + E+ +++++K+ N+ +I
Sbjct: 2492 KGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKK-IVNLQKIV 2548
Query: 412 KERIHE-ISSAVTIDIVKKENEL---KEILTKECLKLSKLKIDIPRD--LDQDLPAHKKI 465
+E++ + S + ++ V++ + + ++ E + + ++ R+ L D+ A +
Sbjct: 2549 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA---L 2605
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTA-----KAVXXXXXXXXXXXXXXFDTLEE 520
T+ L +Q T +EKE++ + K + +
Sbjct: 2606 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2665
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE---- 576
+ +V+ L + T+L+ S +E + N ++ L E A K +A +EK L E
Sbjct: 2666 SPQDVEVL-KTTTELFHS--NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2722
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSC 620
K+ +T L ++ +++ K ++ +E ET+ E +++C
Sbjct: 2723 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2766
Score = 61.3 bits (142), Expect = 2e-08
Identities = 188/1036 (18%), Positives = 417/1036 (40%), Gaps = 85/1036 (8%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT-K 122
+E ++ ++++L+ +L Q+S+++ +NL+ E + +L+ ++++L+ +L +
Sbjct: 1621 REDQEQLQEEIKRLNRQL----AQRSSIDN--ENLVSERER--VLLEELEALKQLSLAGR 1672
Query: 123 DK---EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES---DNLNKEVDDLKKNNE 176
+K E++N S +T++ N+ + E T ++ E + L+ E L+K N
Sbjct: 1673 EKLCCELRN--SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANN 1730
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
L + +++ K E IG + + ++ + I + + + + +T
Sbjct: 1731 RLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTR 1790
Query: 237 TRYNKICTLQSELDAGREDCK---ELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
I + D R D ++ E+ T + L + ++D EN E
Sbjct: 1791 VTDESIPSYSGS-DMPRNDINMWSKVTEEGTELSQRL-VRSGFAGTEIDP---ENEEL-- 1843
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
+ + S ++ + L E + S+ + + + + + T SL E L +
Sbjct: 1844 -MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRE 1902
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
+ + + +++ + +K +G ++ E K++ E+ + +I++ L
Sbjct: 1903 RLHEESRAR-EQLAVELSKAEGVIDGYADE-KTLFERQIQEKTDIIDRLE--QELLCASN 1958
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
R+ E+ + +++E EL KE +K ++ Q L +K+ + + L
Sbjct: 1959 RLQELEAEQ--QQIQEERELLS-RQKEAMKAEAGPVE-----QQLLQETEKL--MKEKLE 2008
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
Q + + +++K+ LE + V D ++ K L +
Sbjct: 2009 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2068
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
L + +D + + +EI L+ + K + +SE + E ++ N LKE
Sbjct: 2069 FLDEQAIDREHER----DVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLA--NHLKE 2121
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ + L KE +++ + I++ F + +++ +L+
Sbjct: 2122 KTDKCSEL----LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHF 2177
Query: 654 XXDEAK---SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
EAK SL Q A ++ + K ++ + LE ++ + E +N + +L Q++
Sbjct: 2178 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2237
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL--ES 768
K E T+L EL + + K D + ++ S +A++ T + ++ G+ A++ E
Sbjct: 2238 KK---ESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMS--TQDQHVLFGKFAQIIQEK 2291
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
++ +Q + + RDL + S + + +
Sbjct: 2292 EVEIDQ---LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE 2348
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
E+ QL E + QQEL ++ ++ + +E Q + EKL+LEQQV
Sbjct: 2349 EIEQLNEVIEKLQQELANIGQKTSM---NAHSLSEEADSLKHQLDVVIAEKLALEQQVET 2405
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD--AEVEKNKRLMKTIEEL 946
E++ + V ++ F ++ L S+ +R S + + +N + I+ L
Sbjct: 2406 ANEEMTFMKNVLKETNF-----KMNQLTQELFSLKRERESVEKIQSIPENS-VNVAIDHL 2459
Query: 947 RYKKQDLKNTVTK-MQKAMEKYTKKDKEFEAKRK-ELEDCKAELEELKQRYKELDEECET 1004
K +L+ +T+ K++E T K FE K + + + L +L+ D E
Sbjct: 2460 SKDKPELEVVLTEDALKSLENQT-YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2518
Query: 1005 CAEYLKQREEQCKRLKEAKIALEIVD--KLSNQKVALEKQIESLSNTPVSNSTMYVATGS 1062
C + +K +EQ + + + +IV+ K+ +KVA + + V +
Sbjct: 2519 CYKQIKDMQEQ-GQFETEMLQKKIVNLQKIVEEKVA-AALVSQIQLEAVQEYAKFCQDNQ 2576
Query: 1063 AIVQNQQITDVMKENQ 1078
I + T++ NQ
Sbjct: 2577 TISSEPERTNIQNLNQ 2592
Score = 59.7 bits (138), Expect = 6e-08
Identities = 177/921 (19%), Positives = 369/921 (40%), Gaps = 82/921 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ ++ + L + ++N T S S + LQ + L++ + + E D+L ++
Sbjct: 235 SQKLQIQFQQLQASETLRNSTHS----STAADLLQAKQQILTH--QQQLEEQDHL---LE 285
Query: 170 DLKKNNECLTQKCIDLEKLVN----ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
D +K E T + L++ + E + K+ N + + KE +I+ L+ + +
Sbjct: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNT---KIIEE 341
Query: 226 LNRSISDSNTSTRYNKIC-TLQSELDAGREDCKELCEDFTSIKN--HLELHEPNMTMDLD 282
+++ + T +K+ LQ ++ ++ K + + T+ K E M
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 401
Query: 283 EKLGENN----EFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
E+L + N +FET V+ M E +R L L +L + I + K L+
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHM 457
Query: 338 AEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ + M+N + Y I ++E K V +NE +L+ N + L
Sbjct: 458 AQMEEMKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKE 514
Query: 397 QL-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
+L + E C + R ++ + E+S S I ++ +E E K D+ +
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
+ + K++ + +A +T Y++ +EKEK + A++
Sbjct: 575 IVSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLRT----- 627
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 628 -QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF- 683
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 684 -EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
Query: 635 ADI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTH 689
++ L ++ L +N LK+ E+KT D ++ +
Sbjct: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQE 800
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESS 745
E+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 746 REAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXX 798
+ + + L KD +E + E + +++ A +
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 799 XTFGDENRDLGENPKLDDS---PKRSISVISDSEVSQ----LKERLLSCQQELDDLKERY 851
TF E ++GE + D + K ++ E+SQ L E+L E+ L E
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKPKPGEISFLNEEV 980
Query: 852 KELDDECETCAEYLQERDEQCARLKKEKL-SLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
K L E E + +E + + E + S + QVS+L + + T + + V
Sbjct: 981 KSLKPEKEPVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040
Query: 911 NTDEDWANLHSVVVDRMSYDAEV--EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYT 968
+ E+ +V D++S++ E++K+ ++ L ++ T+ +
Sbjct: 1041 SFGEE---SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ----PSEND 1093
Query: 969 KKDKEFEAKRKELEDCKAELE 989
K KE + E D + ++E
Sbjct: 1094 KLQKELNVLKSEQNDLRLQME 1114
Score = 59.3 bits (137), Expect = 8e-08
Identities = 151/705 (21%), Positives = 300/705 (42%), Gaps = 69/705 (9%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK--EQKSAL 91
N IIE + ++L+D +T + K+ L+E + N +++ + EL + K E++S+
Sbjct: 335 NTKIIEEEKKTLELKDK--LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 92 EGKY-QNLILETQTRDLLMSQ-----IKSLEMENLTKDKEIKNLTDSL------KTKSKK 139
E K + E Q R+ SQ ++ +E E K ++++ D + + K +
Sbjct: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL 452
Query: 140 INE---LQEENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN- 194
I + EE T MEN S N+ D +K N + + I L+ ++ E
Sbjct: 453 IRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 512
Query: 195 --KIGP--KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD--SNTSTRYNKICT---L 245
++G + CA + E+L++ L + + + ++I++ S + + + T L
Sbjct: 513 KEELGLILEEKCALQRQLEDLVEELSFSREQ-IQRARQTIAEQESKLNEAHKSLSTVEDL 571
Query: 246 QSELDAGREDCKELC----EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK--VM 299
++E+ + E KEL + T+ K LE+ E LD ++ E+ E E + ++ ++
Sbjct: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD-RMAESQEAELERLRTQLL 630
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+ L+ L E L + + +I++ KD+L + +D + M I
Sbjct: 631 FSHEEELSKLKEDL----EIEHRINIEKLKDNLGIHYKQQ-----IDGLQNEMSQKIETM 681
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKS-VNEKLASLNSQLIEKENACNILRIQKERIHEI 418
Q + D ++ K ++ ++++ +S VN K + Q+ E + ILR Q+E+
Sbjct: 682 QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR-QEEK---- 736
Query: 419 SSAVTIDIVKKENELK-EILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYE 477
T++ +E +LK E+L K+ + + + D+ Q L A +IL D T +
Sbjct: 737 -EKGTLEQEVQELQLKTELLEKQ---MKEKENDLQEKFAQ-LEAEN--SILKDEKKTLED 789
Query: 478 LSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYK 537
+ + + +E+ + + K+ + E+ + L+EE+ K
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKS-KSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
Query: 538 S-KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
+ E N +N ++ E LK+ + K E +KL L ++ +
Sbjct: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 597 SLKSLNDVITREKETQASELERSCQVIKQNGFEL-DKM---KADILMXXXXXXXXXXXXX 652
++K + V +K A LE +V++++ EL +K+ K + L
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMG-EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967
Query: 653 XXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
E L E+ +LK + E + C LEI I H + +Q+
Sbjct: 968 PKPGEISFLNEEVKSLKPEKEPVSLRCRELEI-IINHNRAENVQS 1011
Score = 58.0 bits (134), Expect = 2e-07
Identities = 113/585 (19%), Positives = 247/585 (42%), Gaps = 48/585 (8%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLSEKDNKLTEL 584
S +E K+Y+ + D+ N N +I +E I+ L I + E+K L L +K +L
Sbjct: 299 SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 585 VSTING-LKEENNSLKSLNDVIT--REKETQASE----LERSCQVIKQNGFELDKMKADI 637
+ + + ++N +K++ +T ++KE Q+SE L + + +++ + + + DI
Sbjct: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ E + Q + +Q E + +++E +KT K E++N
Sbjct: 419 VQRMEQETQRKLEQLRA--ELDEMYGQQIVQMKQ-ELIRQHMAQME-EMKTRHK-GEMEN 473
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-K 756
+ + ED + +NEL K + + ++L E L Q +
Sbjct: 474 ALRSYSNITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
DLVE E R QT DL
Sbjct: 532 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV------------EDLKAEIVSAS 579
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETC-AEYLQERDEQCAR 874
++ + + ++EV+ K +L ++E + + +R E + E E + L +E+ ++
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 639
Query: 875 LKKEKLSLEQQVS--NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK E L +E +++ LK+ + + +++ + +++ + E
Sbjct: 640 LK-EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ K K L +++ + K +++ + ++QK +E +++KE +E+++ + + E L+
Sbjct: 699 ISKLKDLQQSL--VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 756
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
++ KE + + + E Q E + LK+ K LE + K+ + V+ E+++ L +
Sbjct: 757 KQMKEKENDLQ---EKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSK 812
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
+ V ++I +++EN+ LK+ +L +K+ T
Sbjct: 813 SKDS--------VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
Score = 54.4 bits (125), Expect = 2e-06
Identities = 160/730 (21%), Positives = 310/730 (42%), Gaps = 64/730 (8%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 664 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 780
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+ + + N A+ + N Q L Y L K+ + DS +
Sbjct: 841 EEIEKQRNTFS----FAEKNFEVN-YQELQEEY-ACLLKVKDDLEDSKNKQELE----YK 890
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEI-KR 304
S+L A E+ + T++K + + + T + ++GE E +T + E+ KR
Sbjct: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
Query: 305 NLNSLSEQLIN-NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID- 362
LS++L + +E K K + + + L E SL E ++ IIN + +
Sbjct: 951 EKLELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRE--LEIIINHNRAEN 1008
Query: 363 LDEILEKYTKVQGDLNECTS-----ELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
+ + + + + TS + VN+ + ++E + + + + +E E
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI--TQ 475
+ V KE+ L+ E KL K ++++ + DL + + +L+ T
Sbjct: 1069 QLILDHLPSVTKESSLRATQPSENDKLQK-ELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127
Query: 476 YELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
+ R E EK+K L+ E A+ +E +E K LH
Sbjct: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187
Query: 532 LTKLYKSKVDENNANL-NLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
+ KL K+ +E + L L +L E ALK + +++ +N+ EL
Sbjct: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247
Query: 590 GLKEENNSLKSLNDVITRE------KETQASEL--ERSCQVIKQNGFE-LDKMKADILMX 640
+++ ++ +L + +T E +T+ S++ +++ + + G E L K + + L
Sbjct: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307
Query: 641 XXXXXXXXXXXXXXXDEAKSL--LEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ SL LE+ L+EQ +E S L+ +K E+ E +
Sbjct: 1308 HSQMTNLEDIDVNHKSKLSSLQDLEKTKQLEEQVQELESLISSLQQQLKETEQNYEAE-- 1365
Query: 699 MIMRLQKQIQ 708
I LQK++Q
Sbjct: 1366 -IHCLQKRLQ 1374
Score = 50.0 bits (114), Expect = 5e-05
Identities = 54/263 (20%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 849 ERYKELDDECETCAEY-LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF 905
+R +E + + EY +Q++ Q ++ E S++ + + L+EQ+ +++ V E +++
Sbjct: 3110 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3169
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
A + + H + + ++ EV+ + + + +Q ++Q A+E
Sbjct: 3170 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR---ELQWALE 3226
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQREEQCKRLKE 1021
K K + E ++ELED K LE KQR +L+ E+ + +Q+ E + L +
Sbjct: 3227 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYD 3286
Query: 1022 AKIA------LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVM 1074
A+++ LE+ L ++KV + + +L ++ + + G+ + D++
Sbjct: 3287 AQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 3346
Query: 1075 KENQK-LKKMNAKLITICKKRGK 1096
KE QK L++ +++++ + + K
Sbjct: 3347 KELQKQLEEKHSRIVELLNETEK 3369
Score = 48.0 bits (109), Expect = 2e-04
Identities = 74/334 (22%), Positives = 141/334 (42%), Gaps = 19/334 (5%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT 121
S+K+ + E+ E+LS E + E KS L L + + + ++++ +E
Sbjct: 3143 SMKDRATELQ---EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3199
Query: 122 KDKEIKNLTDSLKTKSKKINELQ----EENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
K E+ L D+L ++ KK ELQ +E L + E ++L ++ K+ N
Sbjct: 3200 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3259
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L ++L+NES+ KI + + +L E ++L + K+ R S+T
Sbjct: 3260 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV-RIREMSSTLD 3318
Query: 238 RYNKI-CTLQSELDAGREDCKELCED-FTSIKNHLELHEPNMTMDLDEKLGENNEFETKA 295
R ++ LQS G+ ED ++ LE + L+E E + ++
Sbjct: 3319 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET--EKYKLDSLQ 3376
Query: 296 VKVMSEIKRNLNS---LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLDVFEIL 351
+ E R ++ +EQ N E +K + + L L+ + LD+
Sbjct: 3377 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3436
Query: 352 MDNIINKYQ---IDLDEILEKYTKVQGDLNECTS 382
+ I+ ++Q ++ +E E + +LNE T+
Sbjct: 3437 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 3470
Score = 46.8 bits (106), Expect = 4e-04
Identities = 108/523 (20%), Positives = 224/523 (42%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 364 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNI 481
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L TQ E +++L+ D+ E +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 662 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 717
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 718 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 772
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 875
Score = 46.0 bits (104), Expect = 8e-04
Identities = 64/282 (22%), Positives = 118/282 (41%), Gaps = 20/282 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+E Q K++D + ++ S I L+ EK + EL D+++Q ALE + +
Sbjct: 2007 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK-NTELMDLRQQNQALEKQLEK 2065
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT--KSKKINELQ-EENDTLSNLI 154
+ R L Q E E +EI+ L LK + + I+E Q E + L+N +
Sbjct: 2066 M------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2119
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
E + L + L+++ + ++ LE V E E + + +
Sbjct: 2120 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-----LVSADTFQKVEDR 2174
Query: 215 LHIGYDNTLSKLNRSI---SDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHL 270
H G +L+ + ++ + R K I L+ +L+ RE+ + E+ + L
Sbjct: 2175 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2234
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ + T L E EN F+ K+ IK + +++S Q
Sbjct: 2235 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMSTQ 2275
Score = 44.0 bits (99), Expect = 0.003
Identities = 89/420 (21%), Positives = 180/420 (42%), Gaps = 50/420 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLE----INIKTHEKTAE--IQ-NRMIMRLQKQIQE 709
E + + L L EQ ++ +L+ + TH TA +Q + I+ Q+Q++E
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D L + + K + T + L+ V ++E ++ N + E I EL +
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTK 337
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
I E+ T+ +N+++ +N KL+ + + S E
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEI-KNMKLELTNSKQKERQSSEE 393
Query: 830 VSQL--------KERLLSCQQELDDLKERYKELDDECETCAEYLQER-DEQCARLKKEKL 880
+ QL K Q E D ++ +E + E L E +Q ++K+E +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 881 SLEQQVSNLKE-QIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMSY---DAEVEK 935
Q ++ ++E + R + +E + ++++ VN ED L +V ++ ++ D +K
Sbjct: 454 --RQHMAQMEEMKTRHKGEMENALRSYSNITVN--EDQIKLMNVAINELNIKLQDTNSQK 509
Query: 936 NK---RLMKTIEE---LRYKKQDLKNTVT----KMQKAMEKYTKKDKEFEAKRKEL---E 982
K L +EE L+ + +DL ++ ++Q+A + +++ + K L E
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-NQKVALEK 1041
D KAE+ + KEL+ + E K + E ++ K A ++D+++ +Q+ LE+
Sbjct: 570 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA-----VLDRMAESQEAELER 624
Score = 43.6 bits (98), Expect = 0.004
Identities = 77/399 (19%), Positives = 190/399 (47%), Gaps = 28/399 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEI-- 126
E +++++L+ ++ +++Q L+ N ++E + L+ +++ ++E L D+E
Sbjct: 2290 EKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEKNE--LIRDLET-QIECLMSDQECVK 2343
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+N + ++ ++ I +LQ+E L+N+ + + +L++E D LK + + + + LE
Sbjct: 2344 RNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2400
Query: 187 KLV-NESENKIGPKNICAQCKLKEN-LIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ V +E KN+ + K N L Q L + + + +SI +++ + + +
Sbjct: 2401 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 2460
Query: 244 TLQSELDAG-REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ EL+ ED + E+ T K+ E + ++L+ +L + + +++
Sbjct: 2461 KDKPELEVVLTEDALKSLENQTYFKS-FEENGKGSIINLETRLLQLESTVSAKDLELTQC 2519
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYK---DSLLAVLDAEFGTTSLDVF-EILMDNIINK 358
+ + + EQ K ++ K + + A L ++ ++ + + DN
Sbjct: 2520 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 2579
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + I + +++ D E S++ ++ +++ L SQ++E + L ++KE++ EI
Sbjct: 2580 SEPERTNI-QNLNQLRED--ELGSDISALTLRISELESQVVEMHTS---LILEKEQV-EI 2632
Query: 419 SSAVTIDIVKKENELKEILT-KECLKLSKLKIDIPRDLD 456
+ ++ KK EL+++L E + K K P+D++
Sbjct: 2633 AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2671
Score = 43.2 bits (97), Expect = 0.005
Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 58/420 (13%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR---DLLMSQIKSLEMEN 119
+K E N K+ +L+ ELF +K ++ ++E K Q+ I E D L LE+
Sbjct: 2413 MKNVLKETNFKMNQLTQELFSLKRERESVE-KIQS-IPENSVNVAIDHLSKDKPELEVV- 2469
Query: 120 LTKD--KEIKNLT--DSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKK- 173
LT+D K ++N T S + K I L+ L + + E K++ D+++
Sbjct: 2470 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2529
Query: 174 ---NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI 230
E L +K ++L+K+V E K+ L+ + + + + +
Sbjct: 2530 GQFETEMLQKKIVNLQKIVEE--------------KVAAALVSQIQL---EAVQEYAKFC 2572
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
D+ T + + +Q+ L+ RED EL D +++ + E + +++ L E
Sbjct: 2573 QDNQTISSEPERTNIQN-LNQLRED--ELGSDISALTLRISELE-SQVVEMHTSLILEKE 2628
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
A K + E ++ L L + L NE K+ R K+ + D E T+ ++F
Sbjct: 2629 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ------REKEKKRSPQDVEVLKTTTELFH- 2681
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
N + + +L+ + + + +EL S EK L +L+ KE N+ +
Sbjct: 2682 --SNEESGFFNELEALRAESVATK-------AELASYKEKAEKLQEELLVKET--NMTSL 2730
Query: 411 QKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
QK+ R H + + I++KE+E + +K+ L I + + + KI+
Sbjct: 2731 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2790
Score = 43.2 bits (97), Expect = 0.005
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 25/380 (6%)
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRM------IMRLQKQIQEDDKLFIE 716
+ + LK + E + LE NI+ + + E+Q + LQ+Q+ + + E
Sbjct: 3105 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3164
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+++L + + E + +K+LE+ R V T + L+ +A + R Q A
Sbjct: 3165 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3224
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+ F E++ N +L+ ++ ++++S+ +R
Sbjct: 3225 -LEKEKAKLGRSEERDKEELEDLKFSLESQK-QRNLQLNLLLEQQKQLLNESQQKIESQR 3282
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+L +L + + R EL E +E ++ R+ ++ +L + Q S+ Q R
Sbjct: 3283 ML-YDAQLSEEQGRNLELQVLLE--SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3339
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKN 955
P E D+ + HS +V+ ++ E EK K ++T +++ +Q +
Sbjct: 3340 LPSE------DLLKELQKQLEEKHSRIVELLN---ETEKYKLDSLQTRQQMEKDRQVHRK 3390
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T+ Q+A + KK E ++K +ED + +LEE +Q+ +LD E + +++ ++Q
Sbjct: 3391 TLQTEQEANTEGQKKMHELQSK---VEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ 3447
Query: 1016 CKRLKEAKIALEIVDKLSNQ 1035
+E + + I+ + N+
Sbjct: 3448 ELEREEKRESRRILYQNLNE 3467
Score = 37.5 bits (83), Expect = 0.26
Identities = 47/221 (21%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE- 900
Q+L + + K+ D LQ+ + +E L L +Q L+ Q + Q E
Sbjct: 191 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250
Query: 901 -RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + A A+L +++ ++E+ L +E+ + KK+D ++
Sbjct: 251 LRNSTHSSTA-------ADLLQAKQQILTHQQQLEEQDHL---LEDYQKKKEDFTMQISF 300
Query: 960 MQKAMEKY-TKKDKEFEAKRKE--------LEDCKAELEELKQRYKELDEECETCAEYLK 1010
+Q+ ++ Y ++DK+ E KE +E+ ++ E +++ EL ++ T + L
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 1011 QREEQ-CKRLKEAK-IALEIVDKLSNQKVALEKQIESLSNT 1049
+ +EQ ++ +E K + LE+ + ++ + E +I+ L T
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSE-EIKQLMGT 400
>AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein.
Length = 3911
Score = 64.5 bits (150), Expect = 2e-09
Identities = 112/584 (19%), Positives = 249/584 (42%), Gaps = 53/584 (9%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
+++ E+ +++EQ + +N E Q L Q++ + E+ T+ +E++
Sbjct: 2210 IDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKESTTRLQELEQENKLF 2266
Query: 134 KTKSKKINELQEENDTLSN------------LIMENVTESDNLNKEVDDLKKNNECLTQK 181
K +K+ +E+D +S +I E E D LN++V L++ + T
Sbjct: 2267 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2326
Query: 182 CIDLEK--LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ EK L+ + E +I +C +K N + + + + KL + +++ T
Sbjct: 2327 KVIEEKNELIRDLETQIECLMSDQEC-VKRNREEEIE-QLNEVIEKLQQELANIGQKTSM 2384
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
N +L E D+ + + + +++ +E MT + L E N + + +
Sbjct: 2385 NAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF-MKNVLKETNFKMNQLTQEL 2442
Query: 300 SEIKRNLNSLS--EQLINNESKKSKDHIDRYKDSLLAVL--DAEFGTTSLDVFEILMDN- 354
+KR S+ + + N + DH+ + K L VL DA + F+ +N
Sbjct: 2443 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2502
Query: 355 ---IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
IIN + L ++ + +L +C ++K + E+ +++++K+ N+ +I
Sbjct: 2503 KGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKK-IVNLQKIV 2559
Query: 412 KERIHE-ISSAVTIDIVKKENEL---KEILTKECLKLSKLKIDIPRD--LDQDLPAHKKI 465
+E++ + S + ++ V++ + + ++ E + + ++ R+ L D+ A +
Sbjct: 2560 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA---L 2616
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTA-----KAVXXXXXXXXXXXXXXFDTLEE 520
T+ L +Q T +EKE++ + K + +
Sbjct: 2617 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2676
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE---- 576
+ +V+ L + T+L+ S +E + N ++ L E A K +A +EK L E
Sbjct: 2677 SPQDVEVL-KTTTELFHS--NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2733
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSC 620
K+ +T L ++ +++ K ++ +E ET+ E +++C
Sbjct: 2734 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2777
Score = 61.7 bits (143), Expect = 1e-08
Identities = 167/799 (20%), Positives = 326/799 (40%), Gaps = 74/799 (9%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK--EQKSAL 91
N IIE + ++L+D +T + K+ L+E + N +++ + EL + K E++S+
Sbjct: 347 NTKIIEEEKKTLELKDK--LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 404
Query: 92 EGKY-QNLILETQTRDLLMSQ-----IKSLEMENLTKDKEIKNLTDSL------KTKSKK 139
E K + E Q R+ SQ ++ +E E K ++++ D + + K +
Sbjct: 405 EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL 464
Query: 140 INE---LQEENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN- 194
I + EE T MEN S N+ D +K N + + I L+ ++ E
Sbjct: 465 IRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 524
Query: 195 --KIGP--KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD--SNTSTRYNKICT---L 245
++G + CA + E+L++ L + + + ++I++ S + + + T L
Sbjct: 525 KEELGLILEEKCALQRQLEDLVEELSFSREQ-IQRARQTIAEQESKLNEAHKSLSTVEDL 583
Query: 246 QSELDAGREDCKELC----EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK--VM 299
++E+ + E KEL + T+ K LE+ E LD ++ E+ E E + ++ ++
Sbjct: 584 KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD-RMAESQEAELERLRTQLL 642
Query: 300 SEIKRNLNSLSEQL-----INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+ L+ L E L IN E K KD++ + + L E + ++ + DN
Sbjct: 643 FSHEEELSKLKEDLEIEHRINIE--KLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDN 699
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+I K + EI + Q +N + E+ +L L ++E L + +
Sbjct: 700 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 759
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT-----ILF 469
+ + + + +KEN+L+E + + S LK D + L+ L H ++ I
Sbjct: 760 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILK-DEKKTLEDMLKIHTPVSQEERLIFL 818
Query: 470 DALITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHN 523
D++ ++ + S + EIE E L+ + F+ +E
Sbjct: 819 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 878
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E L + L SK + + +K L+EE+ +I + K E + E
Sbjct: 879 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 938
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ ++++ L +V REK + L + +KQ E+ + ++
Sbjct: 939 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV----KS 994
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E + ++ N A Q C+ T+ S L+ + + AE + +
Sbjct: 995 LKQEKEQVSLRCRELEIIINHNRAENVQSCD--TQVSSLLDGVVTMTSRGAE---GSVSK 1049
Query: 703 LQKQIQEDDKLFIEKETKLNELT----NKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ K E+ K+ +E + +T +K E L D+ +V ESS A K
Sbjct: 1050 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRATQPSENDKLQ 1108
Query: 759 VEGRIAELE-SDIRTEQTA 776
E + + E +D+R + A
Sbjct: 1109 KELNVLKSEQNDLRLQMEA 1127
Score = 61.3 bits (142), Expect = 2e-08
Identities = 188/1036 (18%), Positives = 417/1036 (40%), Gaps = 85/1036 (8%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT-K 122
+E ++ ++++L+ +L Q+S+++ +NL+ E + +L+ ++++L+ +L +
Sbjct: 1632 REDQEQLQEEIKRLNRQL----AQRSSIDN--ENLVSERER--VLLEELEALKQLSLAGR 1683
Query: 123 DK---EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES---DNLNKEVDDLKKNNE 176
+K E++N S +T++ N+ + E T ++ E + L+ E L+K N
Sbjct: 1684 EKLCCELRN--SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANN 1741
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS 236
L + +++ K E IG + + ++ + I + + + + +T
Sbjct: 1742 RLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTR 1801
Query: 237 TRYNKICTLQSELDAGREDCK---ELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
I + D R D ++ E+ T + L + ++D EN E
Sbjct: 1802 VTDESIPSYSGS-DMPRNDINMWSKVTEEGTELSQRL-VRSGFAGTEIDP---ENEEL-- 1854
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
+ + S ++ + L E + S+ + + + + + T SL E L +
Sbjct: 1855 -MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRE 1913
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
+ + + +++ + +K +G ++ E K++ E+ + +I++ L
Sbjct: 1914 RLHEESRAR-EQLAVELSKAEGVIDGYADE-KTLFERQIQEKTDIIDRLE--QELLCASN 1969
Query: 414 RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI 473
R+ E+ + +++E EL KE +K ++ Q L +K+ + + L
Sbjct: 1970 RLQELEAEQ--QQIQEERELLS-RQKEAMKAEAGPVE-----QQLLQETEKL--MKEKLE 2019
Query: 474 TQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
Q + + +++K+ LE + V D ++ K L +
Sbjct: 2020 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRK 2079
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
L + +D + + +EI L+ + K + +SE + E ++ N LKE
Sbjct: 2080 FLDEQAIDREHER----DVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLA--NHLKE 2132
Query: 594 ENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXX 653
+ + L KE +++ + I++ F + +++ +L+
Sbjct: 2133 KTDKCSEL----LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHF 2188
Query: 654 XXDEAK---SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
EAK SL Q A ++ + K ++ + LE ++ + E +N + +L Q++
Sbjct: 2189 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2248
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL--ES 768
K E T+L EL + + K D + ++ S +A++ T + ++ G+ A++ E
Sbjct: 2249 KK---ESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMS--TQDQHVLFGKFAQIIQEK 2302
Query: 769 DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS 828
++ +Q + + RDL + S + + +
Sbjct: 2303 EVEIDQ---LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE 2359
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
E+ QL E + QQEL ++ ++ + +E Q + EKL+LEQQV
Sbjct: 2360 EIEQLNEVIEKLQQELANIGQKTSM---NAHSLSEEADSLKHQLDVVIAEKLALEQQVET 2416
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD--AEVEKNKRLMKTIEEL 946
E++ + V ++ F ++ L S+ +R S + + +N + I+ L
Sbjct: 2417 ANEEMTFMKNVLKETNF-----KMNQLTQELFSLKRERESVEKIQSIPENS-VNVAIDHL 2470
Query: 947 RYKKQDLKNTVTK-MQKAMEKYTKKDKEFEAKRK-ELEDCKAELEELKQRYKELDEECET 1004
K +L+ +T+ K++E T K FE K + + + L +L+ D E
Sbjct: 2471 SKDKPELEVVLTEDALKSLENQT-YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQ 2529
Query: 1005 CAEYLKQREEQCKRLKEAKIALEIVD--KLSNQKVALEKQIESLSNTPVSNSTMYVATGS 1062
C + +K +EQ + + + +IV+ K+ +KVA + + V +
Sbjct: 2530 CYKQIKDMQEQ-GQFETEMLQKKIVNLQKIVEEKVA-AALVSQIQLEAVQEYAKFCQDNQ 2587
Query: 1063 AIVQNQQITDVMKENQ 1078
I + T++ NQ
Sbjct: 2588 TISSEPERTNIQNLNQ 2603
Score = 60.9 bits (141), Expect = 2e-08
Identities = 153/818 (18%), Positives = 329/818 (40%), Gaps = 68/818 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ ++ + L + ++N T S S + LQ + L++ + + E D+L ++
Sbjct: 247 SQKLQIQFQQLQASETLRNSTHS----STAADLLQAKQQILTH--QQQLEEQDHL---LE 297
Query: 170 DLKKNNECLTQKCIDLEKLVN----ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
D +K E T + L++ + E + K+ N + + KE +I+ L+ + +
Sbjct: 298 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNT---KIIEE 353
Query: 226 LNRSISDSNTSTRYNKIC-TLQSELDAGREDCKELCEDFTSIKN--HLELHEPNMTMDLD 282
+++ + T +K+ LQ ++ ++ K + + T+ K E M
Sbjct: 354 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 413
Query: 283 EKLGENN----EFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
E+L + N +FET V+ M E +R L L +L + I + K L+
Sbjct: 414 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHM 469
Query: 338 AEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ + M+N + Y I ++E K V +NE +L+ N + L
Sbjct: 470 AQMEEMKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKE 526
Query: 397 QL-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
+L + E C + R ++ + E+S S I ++ +E E K D+ +
Sbjct: 527 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 586
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
+ + K++ + +A +T Y++ +EKEK + A++
Sbjct: 587 IVSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLRT----- 639
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 640 -QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF- 695
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 696 -EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 754
Query: 635 ADI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTH 689
++ L ++ L +N LK+ E+KT D ++ +
Sbjct: 755 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQE 812
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESS 745
E+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 813 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 872
Query: 746 REAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXX 798
+ + + L KD +E + E + +++ A +
Sbjct: 873 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 932
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
TF E ++GE + D + ++ E +L +RL ++ LK+++ E+
Sbjct: 933 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLN 989
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
E QE+++ R ++ ++ + + + TQ
Sbjct: 990 EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1027
Score = 58.0 bits (134), Expect = 2e-07
Identities = 113/585 (19%), Positives = 247/585 (42%), Gaps = 48/585 (8%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLSEKDNKLTEL 584
S +E K+Y+ + D+ N N +I +E I+ L I + E+K L L +K +L
Sbjct: 311 SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 370
Query: 585 VSTING-LKEENNSLKSLNDVIT--REKETQASE----LERSCQVIKQNGFELDKMKADI 637
+ + + ++N +K++ +T ++KE Q+SE L + + +++ + + + DI
Sbjct: 371 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 430
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ E + Q + +Q E + +++E +KT K E++N
Sbjct: 431 VQRMEQETQRKLEQLRA--ELDEMYGQQIVQMKQ-ELIRQHMAQME-EMKTRHK-GEMEN 485
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-K 756
+ + ED + +NEL K + + ++L E L Q +
Sbjct: 486 ALRSYSNITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 543
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
DLVE E R QT DL
Sbjct: 544 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV------------EDLKAEIVSAS 591
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETC-AEYLQERDEQCAR 874
++ + + ++EV+ K +L ++E + + +R E + E E + L +E+ ++
Sbjct: 592 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 651
Query: 875 LKKEKLSLEQQVS--NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK E L +E +++ LK+ + + +++ + +++ + E
Sbjct: 652 LK-EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 710
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ K K L +++ + K +++ + ++QK +E +++KE +E+++ + + E L+
Sbjct: 711 ISKLKDLQQSL--VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 768
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
++ KE + + + E Q E + LK+ K LE + K+ + V+ E+++ L +
Sbjct: 769 KQMKEKENDLQ---EKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSK 824
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
+ V ++I +++EN+ LK+ +L +K+ T
Sbjct: 825 SKDS--------VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 861
Score = 52.8 bits (121), Expect = 7e-06
Identities = 158/729 (21%), Positives = 309/729 (42%), Gaps = 63/729 (8%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 676 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 735
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 736 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 792
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 793 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 852
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+ + + N A+ + N Q L Y L K+ + DS +
Sbjct: 853 EEIEKQRNTFS----FAEKNFEVN-YQELQEEY-ACLLKVKDDLEDSKNKQELE----YK 902
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEI-KR 304
S+L A E+ + T++K + + + T + ++GE E +T + E+ KR
Sbjct: 903 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 962
Query: 305 NLNSLSEQLIN-NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID- 362
LS++L + +E K K + + + L E SL E ++ IIN + +
Sbjct: 963 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE--LEIIINHNRAEN 1020
Query: 363 LDEILEKYTKVQGDLNECTS-----ELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
+ + + + + TS + VN+ + ++E + + + + +E E
Sbjct: 1021 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1080
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI--TQ 475
+ V KE+ L+ E KL K ++++ + DL + + +L+ T
Sbjct: 1081 QLILDHLPSVTKESSLRATQPSENDKLQK-ELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1139
Query: 476 YELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
+ R E EK+K L+ E A+ +E +E K LH
Sbjct: 1140 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1199
Query: 532 LTKLYKSKVDENNANL-NLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
+ KL K+ +E + L L +L E ALK + +++ +N+ EL
Sbjct: 1200 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1259
Query: 590 GLKEENNSLKSLNDVITRE------KETQASEL--ERSCQVIKQNGFE-LDKMKADILMX 640
+++ ++ +L + +T E +T+ S++ +++ + + G E L K + + L
Sbjct: 1260 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1319
Query: 641 XXXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ SL + + L+EQ +E S L+ +K E+ E +
Sbjct: 1320 HSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE--- 1376
Query: 700 IMRLQKQIQ 708
I LQK++Q
Sbjct: 1377 IHCLQKRLQ 1385
Score = 50.0 bits (114), Expect = 5e-05
Identities = 54/263 (20%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 849 ERYKELDDECETCAEY-LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF 905
+R +E + + EY +Q++ Q ++ E S++ + + L+EQ+ +++ V E +++
Sbjct: 3113 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3172
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
A + + H + + ++ EV+ + + + +Q ++Q A+E
Sbjct: 3173 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR---ELQWALE 3229
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQREEQCKRLKE 1021
K K + E ++ELED K LE KQR +L+ E+ + +Q+ E + L +
Sbjct: 3230 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYD 3289
Query: 1022 AKIA------LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVM 1074
A+++ LE+ L ++KV + + +L ++ + + G+ + D++
Sbjct: 3290 AQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 3349
Query: 1075 KENQK-LKKMNAKLITICKKRGK 1096
KE QK L++ +++++ + + K
Sbjct: 3350 KELQKQLEEKHSRIVELLNETEK 3372
Score = 48.0 bits (109), Expect = 2e-04
Identities = 74/334 (22%), Positives = 141/334 (42%), Gaps = 19/334 (5%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT 121
S+K+ + E+ E+LS E + E KS L L + + + ++++ +E
Sbjct: 3146 SMKDRATELQ---EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3202
Query: 122 KDKEIKNLTDSLKTKSKKINELQ----EENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
K E+ L D+L ++ KK ELQ +E L + E ++L ++ K+ N
Sbjct: 3203 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3262
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L ++L+NES+ KI + + +L E ++L + K+ R S+T
Sbjct: 3263 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV-RIREMSSTLD 3321
Query: 238 RYNKI-CTLQSELDAGREDCKELCED-FTSIKNHLELHEPNMTMDLDEKLGENNEFETKA 295
R ++ LQS G+ ED ++ LE + L+E E + ++
Sbjct: 3322 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET--EKYKLDSLQ 3379
Query: 296 VKVMSEIKRNLNS---LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLDVFEIL 351
+ E R ++ +EQ N E +K + + L L+ + LD+
Sbjct: 3380 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3439
Query: 352 MDNIINKYQ---IDLDEILEKYTKVQGDLNECTS 382
+ I+ ++Q ++ +E E + +LNE T+
Sbjct: 3440 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 3473
Score = 46.8 bits (106), Expect = 4e-04
Identities = 108/523 (20%), Positives = 224/523 (42%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 376 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 434
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 435 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNI 493
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 494 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 553
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 554 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 613
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L TQ E +++L+ D+ E +
Sbjct: 614 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 673
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 674 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 729
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 730 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 784
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 785 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 844
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 845 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 887
Score = 46.0 bits (104), Expect = 8e-04
Identities = 64/282 (22%), Positives = 118/282 (41%), Gaps = 20/282 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+E Q K++D + ++ S I L+ EK + EL D+++Q ALE + +
Sbjct: 2018 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK-NTELMDLRQQNQALEKQLEK 2076
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT--KSKKINELQ-EENDTLSNLI 154
+ R L Q E E +EI+ L LK + + I+E Q E + L+N +
Sbjct: 2077 M------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2130
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
E + L + L+++ + ++ LE V E E + + +
Sbjct: 2131 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-----LVSADTFQKVEDR 2185
Query: 215 LHIGYDNTLSKLNRSI---SDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHL 270
H G +L+ + ++ + R K I L+ +L+ RE+ + E+ + L
Sbjct: 2186 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2245
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ + T L E EN F+ K+ IK + +++S Q
Sbjct: 2246 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMSTQ 2286
Score = 44.0 bits (99), Expect = 0.003
Identities = 89/420 (21%), Positives = 180/420 (42%), Gaps = 50/420 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLE----INIKTHEKTAE--IQ-NRMIMRLQKQIQE 709
E + + L L EQ ++ +L+ + TH TA +Q + I+ Q+Q++E
Sbjct: 232 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 291
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D L + + K + T + L+ V ++E ++ N + E I EL +
Sbjct: 292 QDHLLEDYQKKKEDFTMQISFLQEKIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTK 349
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
I E+ T+ +N+++ +N KL+ + + S E
Sbjct: 350 IIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEI-KNMKLELTNSKQKERQSSEE 405
Query: 830 VSQL--------KERLLSCQQELDDLKERYKELDDECETCAEYLQER-DEQCARLKKEKL 880
+ QL K Q E D ++ +E + E L E +Q ++K+E +
Sbjct: 406 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 465
Query: 881 SLEQQVSNLKE-QIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMSY---DAEVEK 935
Q ++ ++E + R + +E + ++++ VN ED L +V ++ ++ D +K
Sbjct: 466 --RQHMAQMEEMKTRHKGEMENALRSYSNITVN--EDQIKLMNVAINELNIKLQDTNSQK 521
Query: 936 NK---RLMKTIEE---LRYKKQDLKNTVT----KMQKAMEKYTKKDKEFEAKRKEL---E 982
K L +EE L+ + +DL ++ ++Q+A + +++ + K L E
Sbjct: 522 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 581
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-NQKVALEK 1041
D KAE+ + KEL+ + E K + E ++ K A ++D+++ +Q+ LE+
Sbjct: 582 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA-----VLDRMAESQEAELER 636
Score = 43.6 bits (98), Expect = 0.004
Identities = 77/399 (19%), Positives = 190/399 (47%), Gaps = 28/399 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEI-- 126
E +++++L+ ++ +++Q L+ N ++E + L+ +++ ++E L D+E
Sbjct: 2301 EKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEKNE--LIRDLET-QIECLMSDQECVK 2354
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+N + ++ ++ I +LQ+E L+N+ + + +L++E D LK + + + + LE
Sbjct: 2355 RNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2411
Query: 187 KLV-NESENKIGPKNICAQCKLKEN-LIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ V +E KN+ + K N L Q L + + + +SI +++ + + +
Sbjct: 2412 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 2471
Query: 244 TLQSELDAG-REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ EL+ ED + E+ T K+ E + ++L+ +L + + +++
Sbjct: 2472 KDKPELEVVLTEDALKSLENQTYFKS-FEENGKGSIINLETRLLQLESTVSAKDLELTQC 2530
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYK---DSLLAVLDAEFGTTSLDVF-EILMDNIINK 358
+ + + EQ K ++ K + + A L ++ ++ + + DN
Sbjct: 2531 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 2590
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + I + +++ D E S++ ++ +++ L SQ++E + L ++KE++ EI
Sbjct: 2591 SEPERTNI-QNLNQLRED--ELGSDISALTLRISELESQVVEMHTS---LILEKEQV-EI 2643
Query: 419 SSAVTIDIVKKENELKEILT-KECLKLSKLKIDIPRDLD 456
+ ++ KK EL+++L E + K K P+D++
Sbjct: 2644 AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2682
Score = 43.2 bits (97), Expect = 0.005
Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 58/420 (13%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR---DLLMSQIKSLEMEN 119
+K E N K+ +L+ ELF +K ++ ++E K Q+ I E D L LE+
Sbjct: 2424 MKNVLKETNFKMNQLTQELFSLKRERESVE-KIQS-IPENSVNVAIDHLSKDKPELEVV- 2480
Query: 120 LTKD--KEIKNLT--DSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKK- 173
LT+D K ++N T S + K I L+ L + + E K++ D+++
Sbjct: 2481 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2540
Query: 174 ---NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI 230
E L +K ++L+K+V E K+ L+ + + + + +
Sbjct: 2541 GQFETEMLQKKIVNLQKIVEE--------------KVAAALVSQIQL---EAVQEYAKFC 2583
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
D+ T + + +Q+ L+ RED EL D +++ + E + +++ L E
Sbjct: 2584 QDNQTISSEPERTNIQN-LNQLRED--ELGSDISALTLRISELE-SQVVEMHTSLILEKE 2639
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
A K + E ++ L L + L NE K+ R K+ + D E T+ ++F
Sbjct: 2640 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ------REKEKKRSPQDVEVLKTTTELFH- 2692
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
N + + +L+ + + + +EL S EK L +L+ KE N+ +
Sbjct: 2693 --SNEESGFFNELEALRAESVATK-------AELASYKEKAEKLQEELLVKET--NMTSL 2741
Query: 411 QKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
QK+ R H + + I++KE+E + +K+ L I + + + KI+
Sbjct: 2742 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2801
Score = 43.2 bits (97), Expect = 0.005
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 25/380 (6%)
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRM------IMRLQKQIQEDDKLFIE 716
+ + LK + E + LE NI+ + + E+Q + LQ+Q+ + + E
Sbjct: 3108 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3167
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+++L + + E + +K+LE+ R V T + L+ +A + R Q A
Sbjct: 3168 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3227
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+ F E++ N +L+ ++ ++++S+ +R
Sbjct: 3228 -LEKEKAKLGRSEERDKEELEDLKFSLESQK-QRNLQLNLLLEQQKQLLNESQQKIESQR 3285
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+L +L + + R EL E +E ++ R+ ++ +L + Q S+ Q R
Sbjct: 3286 ML-YDAQLSEEQGRNLELQVLLE--SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3342
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKN 955
P E D+ + HS +V+ ++ E EK K ++T +++ +Q +
Sbjct: 3343 LPSE------DLLKELQKQLEEKHSRIVELLN---ETEKYKLDSLQTRQQMEKDRQVHRK 3393
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T+ Q+A + KK E ++K +ED + +LEE +Q+ +LD E + +++ ++Q
Sbjct: 3394 TLQTEQEANTEGQKKMHELQSK---VEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ 3450
Query: 1016 CKRLKEAKIALEIVDKLSNQ 1035
+E + + I+ + N+
Sbjct: 3451 ELEREEKRESRRILYQNLNE 3470
Score = 37.5 bits (83), Expect = 0.26
Identities = 47/221 (21%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE- 900
Q+L + + K+ D LQ+ + +E L L +Q L+ Q + Q E
Sbjct: 203 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 262
Query: 901 -RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + A A+L +++ ++E+ L +E+ + KK+D ++
Sbjct: 263 LRNSTHSSTA-------ADLLQAKQQILTHQQQLEEQDHL---LEDYQKKKEDFTMQISF 312
Query: 960 MQKAMEKY-TKKDKEFEAKRKE--------LEDCKAELEELKQRYKELDEECETCAEYLK 1010
+Q+ ++ Y ++DK+ E KE +E+ ++ E +++ EL ++ T + L
Sbjct: 313 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 372
Query: 1011 QREEQ-CKRLKEAK-IALEIVDKLSNQKVALEKQIESLSNT 1049
+ +EQ ++ +E K + LE+ + ++ + E +I+ L T
Sbjct: 373 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSE-EIKQLMGT 412
>AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protein
130c protein.
Length = 1133
Score = 64.5 bits (150), Expect = 2e-09
Identities = 113/535 (21%), Positives = 220/535 (41%), Gaps = 59/535 (11%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKML--- 572
+E V +L EELTKL VDE + + ++I L + K+
Sbjct: 219 QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
Query: 573 -SLSEKDNKLTEL-----VSTINGLKEENNSLKSLN--DVITREKETQASELERSCQVIK 624
+ E++ K T L T ++++ + L D R+ + + + L R ++
Sbjct: 279 ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L K + ++ E + L ++ L ++ + EE
Sbjct: 339 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL--------- 389
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDYDAAVK 740
IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++ +
Sbjct: 390 -IKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 741 DLESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 447 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKLKTLTV 498
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K D E
Sbjct: 499 MFVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSKTDVEE 555
Query: 860 TCAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
+ERD+ +LK E+ L +V+ LK ++++ + +E+ + ++ +
Sbjct: 556 KMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 615
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
LH E K K L + +E L+ K +D+K + K ++Y ++ +
Sbjct: 616 TALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 977 KRKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 719
Score = 58.4 bits (135), Expect = 1e-07
Identities = 136/657 (20%), Positives = 268/657 (40%), Gaps = 59/657 (8%)
Query: 107 LLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
LL+++ KS L ++E + + ++ + I L++E + L LI + + + +
Sbjct: 161 LLVAE-KSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
E + K L ++ L+ ++ + + AQ L+ IQ L T +KL
Sbjct: 220 EKE---KRVTTLKEELTKLKSFALMVVDE--QQRLTAQLTLQRQKIQELTTNAKETHTKL 274
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++++ K L+ EL + +D +I L +E + L +KL
Sbjct: 275 --ALAEARVQEEEQKATRLEKELQT---QTTKFHQDQDTIMAKLT-NEDSQNRQLQQKLA 328
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+ + + + E R+L E+L + + K SK Y ++ + E LD
Sbjct: 329 ALS----RQIDELEETNRSLRKAEEELQDIKEKISKGE---YGNAGIMAEVEELRKRVLD 381
Query: 347 VFEILMDNIINKYQI-DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ + I + Q DL++ LE+ T D +L L L + + C
Sbjct: 382 MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQEC 441
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI 465
L+ E+ + ++ ++ + +KE+ E +L K + L +DL K +
Sbjct: 442 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES-RLEKTEFT----LKEDLTKLKTL 496
Query: 466 TILF-DALITQYE-LSRTDYEIE--KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
T++F D T E L +T+ +++ +L++E V +EE
Sbjct: 497 TVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 556
Query: 522 HNEVKSLHEELTKLYKSKVDENN---ANLNLIKILSEEIDALKIAIAKNE------EKML 572
V ++L K++ ++ N + +N++K + ++A++ KN+ +
Sbjct: 557 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 616
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+L +++NK+ EL + LK + +K++ D + + E + LER + ++
Sbjct: 617 ALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLERR--------YANER 667
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE-KTRDCSRL--EINIKTH 689
KA L ++ ++ EQ L + Q EE K+ SR + K H
Sbjct: 668 DKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIH 727
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
E A +I LQ D ++K KLN+ N+ L R+ + K+LE R
Sbjct: 728 EYMAT--EDLICHLQ-----GDHSVLQK--KLNQQENRNRDLGREIENLTKELERYR 775
Score = 49.6 bits (113), Expect = 6e-05
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 826 SDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYL----QERDEQCARLKKEKL 880
S E Q KE R+ + ++EL LK + DE + L Q+ E K+
Sbjct: 213 SQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
L + ++E+ + +E++ + + D+D D + + +K L
Sbjct: 273 KLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-QKLAALS 331
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
+ I+EL + L+ ++Q EK +K + E+E+ + + +++ + +EL +
Sbjct: 332 RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E C + K+ E + + K+ K+ V+KLS + +ALEK
Sbjct: 392 MEEQCRDLNKRLERETLQSKDFKLE---VEKLSKRIMALEK 429
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/293 (20%), Positives = 132/293 (45%), Gaps = 28/293 (9%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE- 878
+S +++ E +L +L +Q++ +L KE + +QE +++ RL+KE
Sbjct: 236 KSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL 295
Query: 879 -----KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE-DWAN--LHSVVVDRMSYD 930
K +Q K Q + Q K A ++ DE + N L +
Sbjct: 296 QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 355
Query: 931 AEVEK----NKRLMKTIEELRYKKQDLKNT---VTKMQ-------KAMEKYTKKDKEFEA 976
++ K N +M +EELR + D++ + KM+ K +E+ T + K+F+
Sbjct: 356 EKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL 415
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ ++L LE+L+ + + +EC + L++ K+L + +L++ K +
Sbjct: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK---EL 472
Query: 1037 VALEKQIESLSNTPVSNST-MYVATGSAIVQNQQITDVMKENQ-KLKKMNAKL 1087
A+E ++E T + T + T + + + +++ +K+ + KL+ +++L
Sbjct: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
Score = 39.1 bits (87), Expect = 0.086
Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 26/227 (11%)
Query: 865 LQERDEQCARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
LQ RDE LK EK+ L E Q + + + + ++R A F + ED ++
Sbjct: 83 LQARDEVIGILKAEKMDLALLEAQYGFVTPK-KVLEALQRDA-FQAKSTPWQED---IYE 137
Query: 922 VVVDRMSYDAEVEKNKRLMKTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
++ + D VEK+K + I +L ++ + T+ ++++ EK +K KE+ K E
Sbjct: 138 KPMNEL--DKVVEKHKESYRRILGQLLVAEKSRRQTILELEE--EK--RKHKEYMEKSDE 191
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-----AKIALEIVD---KL 1032
C E +E ++ K +D+E ++ E +++E++ LKE AL +VD +L
Sbjct: 192 FI-CLLE-QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
Query: 1033 SNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ Q ++I+ L +N +++ + +A + Q+ T + KE Q
Sbjct: 250 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQ 296
Score = 36.3 bits (80), Expect = 0.61
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 14/188 (7%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQIRT-QQ 897
EL++ K ++KE ++ + E++ +++C RLKK E S E++ ++++ T ++
Sbjct: 174 ELEEEKRKHKEYMEKSD---EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ + FA + V DE + + R K + + Q+ +
Sbjct: 231 ELTKLKSFALMVV--DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 958 TKMQKAMEKYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQRE 1013
T+++K ++ T K ++ + +L + ++ +L+Q+ L +E E L++ E
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 1014 EQCKRLKE 1021
E+ + +KE
Sbjct: 349 EELQDIKE 356
Score = 32.3 bits (70), Expect = 9.9
Identities = 31/131 (23%), Positives = 60/131 (45%), Gaps = 13/131 (9%)
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++K E Y + + K ELEE K+++KE E+ + E++ E++C+RL
Sbjct: 147 VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSD---EFICLLEQECERL 203
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ--ITDVMKEN 1077
K +++D+ + E++ E T T + +V QQ + +
Sbjct: 204 K------KLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
Query: 1078 QKLKKM--NAK 1086
QK++++ NAK
Sbjct: 258 QKIQELTTNAK 268
>AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protein
130b protein.
Length = 1133
Score = 64.5 bits (150), Expect = 2e-09
Identities = 113/535 (21%), Positives = 220/535 (41%), Gaps = 59/535 (11%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKML--- 572
+E V +L EELTKL VDE + + ++I L + K+
Sbjct: 219 QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
Query: 573 -SLSEKDNKLTEL-----VSTINGLKEENNSLKSLN--DVITREKETQASELERSCQVIK 624
+ E++ K T L T ++++ + L D R+ + + + L R ++
Sbjct: 279 ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L K + ++ E + L ++ L ++ + EE
Sbjct: 339 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL--------- 389
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDYDAAVK 740
IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++ +
Sbjct: 390 -IKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 741 DLESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 447 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKLKTLTV 498
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K D E
Sbjct: 499 MFVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSKTDVEE 555
Query: 860 TCAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
+ERD+ +LK E+ L +V+ LK ++++ + +E+ + ++ +
Sbjct: 556 KMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 615
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
LH E K K L + +E L+ K +D+K + K ++Y ++ +
Sbjct: 616 TALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 977 KRKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 719
Score = 58.0 bits (134), Expect = 2e-07
Identities = 136/657 (20%), Positives = 268/657 (40%), Gaps = 59/657 (8%)
Query: 107 LLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
LL+++ KS L ++E + + ++ + I L++E + L LI + + + +
Sbjct: 161 LLVAE-KSHRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
E + K L ++ L+ ++ + + AQ L+ IQ L T +KL
Sbjct: 220 EKE---KRVTTLKEELTKLKSFALMVVDE--QQRLTAQLTLQRQKIQELTTNAKETHTKL 274
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++++ K L+ EL + +D +I L +E + L +KL
Sbjct: 275 --ALAEARVQEEEQKATRLEKELQT---QTTKFHQDQDTIMAKLT-NEDSQNRQLQQKLA 328
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+ + + + E R+L E+L + + K SK Y ++ + E LD
Sbjct: 329 ALS----RQIDELEETNRSLRKAEEELQDIKEKISKGE---YGNAGIMAEVEELRKRVLD 381
Query: 347 VFEILMDNIINKYQI-DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ + I + Q DL++ LE+ T D +L L L + + C
Sbjct: 382 MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQEC 441
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI 465
L+ E+ + ++ ++ + +KE+ E +L K + L +DL K +
Sbjct: 442 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES-RLEKTEFT----LKEDLTKLKTL 496
Query: 466 TILF-DALITQYE-LSRTDYEIE--KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
T++F D T E L +T+ +++ +L++E V +EE
Sbjct: 497 TVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 556
Query: 522 HNEVKSLHEELTKLYKSKVDENN---ANLNLIKILSEEIDALKIAIAKNE------EKML 572
V ++L K++ ++ N + +N++K + ++A++ KN+ +
Sbjct: 557 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 616
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+L +++NK+ EL + LK + +K++ D + + E + LER + ++
Sbjct: 617 ALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLERR--------YANER 667
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE-KTRDCSRL--EINIKTH 689
KA L ++ ++ EQ L + Q EE K+ SR + K H
Sbjct: 668 DKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIH 727
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
E A +I LQ D ++K KLN+ N+ L R+ + K+LE R
Sbjct: 728 EYMAT--EDLICHLQ-----GDHSVLQK--KLNQQENRNRDLGREIENLTKELERYR 775
Score = 49.6 bits (113), Expect = 6e-05
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 826 SDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYL----QERDEQCARLKKEKL 880
S E Q KE R+ + ++EL LK + DE + L Q+ E K+
Sbjct: 213 SQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
L + ++E+ + +E++ + + D+D D + + +K L
Sbjct: 273 KLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-QKLAALS 331
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
+ I+EL + L+ ++Q EK +K + E+E+ + + +++ + +EL +
Sbjct: 332 RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E C + K+ E + + K+ K+ V+KLS + +ALEK
Sbjct: 392 MEEQCRDLNKRLERETLQSKDFKLE---VEKLSKRIMALEK 429
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/293 (20%), Positives = 132/293 (45%), Gaps = 28/293 (9%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE- 878
+S +++ E +L +L +Q++ +L KE + +QE +++ RL+KE
Sbjct: 236 KSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL 295
Query: 879 -----KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE-DWAN--LHSVVVDRMSYD 930
K +Q K Q + Q K A ++ DE + N L +
Sbjct: 296 QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 355
Query: 931 AEVEK----NKRLMKTIEELRYKKQDLKNT---VTKMQ-------KAMEKYTKKDKEFEA 976
++ K N +M +EELR + D++ + KM+ K +E+ T + K+F+
Sbjct: 356 EKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL 415
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ ++L LE+L+ + + +EC + L++ K+L + +L++ K +
Sbjct: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK---EL 472
Query: 1037 VALEKQIESLSNTPVSNST-MYVATGSAIVQNQQITDVMKENQ-KLKKMNAKL 1087
A+E ++E T + T + T + + + +++ +K+ + KL+ +++L
Sbjct: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
Score = 38.7 bits (86), Expect = 0.11
Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 26/227 (11%)
Query: 865 LQERDEQCARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
LQ RDE LK EK+ L E Q + + + + ++R A F + ED ++
Sbjct: 83 LQARDEVIGILKAEKMDLALLEAQYGFVTPK-KVLEALQRDA-FQAKSTPWQED---IYE 137
Query: 922 VVVDRMSYDAEVEKNKRLMKTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
++ + D VEK+K + I +L ++ + T+ ++++ EK +K KE+ K E
Sbjct: 138 KPMNEL--DKVVEKHKESYRRILGQLLVAEKSHRQTILELEE--EK--RKHKEYMEKSDE 191
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-----AKIALEIVD---KL 1032
C E +E ++ K +D+E ++ E +++E++ LKE AL +VD +L
Sbjct: 192 FI-CLLE-QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
Query: 1033 SNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ Q ++I+ L +N +++ + +A + Q+ T + KE Q
Sbjct: 250 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQ 296
Score = 36.3 bits (80), Expect = 0.61
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 14/188 (7%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQIRT-QQ 897
EL++ K ++KE ++ + E++ +++C RLKK E S E++ ++++ T ++
Sbjct: 174 ELEEEKRKHKEYMEKSD---EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ + FA + V DE + + R K + + Q+ +
Sbjct: 231 ELTKLKSFALMVV--DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 958 TKMQKAMEKYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQRE 1013
T+++K ++ T K ++ + +L + ++ +L+Q+ L +E E L++ E
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 1014 EQCKRLKE 1021
E+ + +KE
Sbjct: 349 EELQDIKE 356
>AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protein
130a protein.
Length = 1135
Score = 64.5 bits (150), Expect = 2e-09
Identities = 113/535 (21%), Positives = 220/535 (41%), Gaps = 59/535 (11%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKML--- 572
+E V +L EELTKL VDE + + ++I L + K+
Sbjct: 219 QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
Query: 573 -SLSEKDNKLTEL-----VSTINGLKEENNSLKSLN--DVITREKETQASELERSCQVIK 624
+ E++ K T L T ++++ + L D R+ + + + L R ++
Sbjct: 279 ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L K + ++ E + L ++ L ++ + EE
Sbjct: 339 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL--------- 389
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDYDAAVK 740
IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++ +
Sbjct: 390 -IKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 741 DLESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 447 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKLKTLTV 498
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K D E
Sbjct: 499 MFVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSKTDVEE 555
Query: 860 TCAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
+ERD+ +LK E+ L +V+ LK ++++ + +E+ + ++ +
Sbjct: 556 KMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 615
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
LH E K K L + +E L+ K +D+K + K ++Y ++ +
Sbjct: 616 TALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 977 KRKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 719
Score = 58.4 bits (135), Expect = 1e-07
Identities = 136/657 (20%), Positives = 268/657 (40%), Gaps = 59/657 (8%)
Query: 107 LLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK 166
LL+++ KS L ++E + + ++ + I L++E + L LI + + + +
Sbjct: 161 LLVAE-KSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
Query: 167 EVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL 226
E + K L ++ L+ ++ + + AQ L+ IQ L T +KL
Sbjct: 220 EKE---KRVTTLKEELTKLKSFALMVVDE--QQRLTAQLTLQRQKIQELTTNAKETHTKL 274
Query: 227 NRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLG 286
+++++ K L+ EL + +D +I L +E + L +KL
Sbjct: 275 --ALAEARVQEEEQKATRLEKELQT---QTTKFHQDQDTIMAKLT-NEDSQNRQLQQKLA 328
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+ + + + E R+L E+L + + K SK Y ++ + E LD
Sbjct: 329 ALS----RQIDELEETNRSLRKAEEELQDIKEKISKGE---YGNAGIMAEVEELRKRVLD 381
Query: 347 VFEILMDNIINKYQI-DLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
+ + I + Q DL++ LE+ T D +L L L + + C
Sbjct: 382 MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQEC 441
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKI 465
L+ E+ + ++ ++ + +KE+ E +L K + L +DL K +
Sbjct: 442 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES-RLEKTEFT----LKEDLTKLKTL 496
Query: 466 TILF-DALITQYE-LSRTDYEIE--KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEA 521
T++F D T E L +T+ +++ +L++E V +EE
Sbjct: 497 TVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 556
Query: 522 HNEVKSLHEELTKLYKSKVDENN---ANLNLIKILSEEIDALKIAIAKNE------EKML 572
V ++L K++ ++ N + +N++K + ++A++ KN+ +
Sbjct: 557 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 616
Query: 573 SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+L +++NK+ EL + LK + +K++ D + + E + LER + ++
Sbjct: 617 ALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLERR--------YANER 667
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE-KTRDCSRL--EINIKTH 689
KA L ++ ++ EQ L + Q EE K+ SR + K H
Sbjct: 668 DKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIH 727
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
E A +I LQ D ++K KLN+ N+ L R+ + K+LE R
Sbjct: 728 EYMAT--EDLICHLQ-----GDHSVLQK--KLNQQENRNRDLGREIENLTKELERYR 775
Score = 49.6 bits (113), Expect = 6e-05
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 826 SDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYL----QERDEQCARLKKEKL 880
S E Q KE R+ + ++EL LK + DE + L Q+ E K+
Sbjct: 213 SQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
L + ++E+ + +E++ + + D+D D + + +K L
Sbjct: 273 KLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-QKLAALS 331
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
+ I+EL + L+ ++Q EK +K + E+E+ + + +++ + +EL +
Sbjct: 332 RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E C + K+ E + + K+ K+ V+KLS + +ALEK
Sbjct: 392 MEEQCRDLNKRLERETLQSKDFKLE---VEKLSKRIMALEK 429
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/293 (20%), Positives = 132/293 (45%), Gaps = 28/293 (9%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE- 878
+S +++ E +L +L +Q++ +L KE + +QE +++ RL+KE
Sbjct: 236 KSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL 295
Query: 879 -----KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE-DWAN--LHSVVVDRMSYD 930
K +Q K Q + Q K A ++ DE + N L +
Sbjct: 296 QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 355
Query: 931 AEVEK----NKRLMKTIEELRYKKQDLKNT---VTKMQ-------KAMEKYTKKDKEFEA 976
++ K N +M +EELR + D++ + KM+ K +E+ T + K+F+
Sbjct: 356 EKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL 415
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ ++L LE+L+ + + +EC + L++ K+L + +L++ K +
Sbjct: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK---EL 472
Query: 1037 VALEKQIESLSNTPVSNST-MYVATGSAIVQNQQITDVMKENQ-KLKKMNAKL 1087
A+E ++E T + T + T + + + +++ +K+ + KL+ +++L
Sbjct: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
Score = 39.1 bits (87), Expect = 0.086
Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 26/227 (11%)
Query: 865 LQERDEQCARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
LQ RDE LK EK+ L E Q + + + + ++R A F + ED ++
Sbjct: 83 LQARDEVIGILKAEKMDLALLEAQYGFVTPK-KVLEALQRDA-FQAKSTPWQED---IYE 137
Query: 922 VVVDRMSYDAEVEKNKRLMKTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
++ + D VEK+K + I +L ++ + T+ ++++ EK +K KE+ K E
Sbjct: 138 KPMNEL--DKVVEKHKESYRRILGQLLVAEKSRRQTILELEE--EK--RKHKEYMEKSDE 191
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-----AKIALEIVD---KL 1032
C E +E ++ K +D+E ++ E +++E++ LKE AL +VD +L
Sbjct: 192 FI-CLLE-QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
Query: 1033 SNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ Q ++I+ L +N +++ + +A + Q+ T + KE Q
Sbjct: 250 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQ 296
Score = 36.3 bits (80), Expect = 0.61
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 14/188 (7%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQIRT-QQ 897
EL++ K ++KE ++ + E++ +++C RLKK E S E++ ++++ T ++
Sbjct: 174 ELEEEKRKHKEYMEKSD---EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ + FA + V DE + + R K + + Q+ +
Sbjct: 231 ELTKLKSFALMVV--DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 958 TKMQKAMEKYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQRE 1013
T+++K ++ T K ++ + +L + ++ +L+Q+ L +E E L++ E
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 1014 EQCKRLKE 1021
E+ + +KE
Sbjct: 349 EELQDIKE 356
Score = 32.3 bits (70), Expect = 9.9
Identities = 31/131 (23%), Positives = 60/131 (45%), Gaps = 13/131 (9%)
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++K E Y + + K ELEE K+++KE E+ + E++ E++C+RL
Sbjct: 147 VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSD---EFICLLEQECERL 203
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ--ITDVMKEN 1077
K +++D+ + E++ E T T + +V QQ + +
Sbjct: 204 K------KLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
Query: 1078 QKLKKM--NAK 1086
QK++++ NAK
Sbjct: 258 QKIQELTTNAK 268
>AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protein 90
protein.
Length = 764
Score = 64.5 bits (150), Expect = 2e-09
Identities = 113/535 (21%), Positives = 220/535 (41%), Gaps = 59/535 (11%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKML--- 572
+E V +L EELTKL VDE + + ++I L + K+
Sbjct: 219 QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
Query: 573 -SLSEKDNKLTEL-----VSTINGLKEENNSLKSLN--DVITREKETQASELERSCQVIK 624
+ E++ K T L T ++++ + L D R+ + + + L R ++
Sbjct: 279 ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L K + ++ E + L ++ L ++ + EE
Sbjct: 339 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL--------- 389
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDYDAAVK 740
IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++ +
Sbjct: 390 -IKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 741 DLESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXX 799
+LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 447 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKLKTLTV 498
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K D E
Sbjct: 499 MFVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSKTDVEE 555
Query: 860 TCAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
+ERD+ +LK E+ L +V+ LK ++++ + +E+ + ++ +
Sbjct: 556 KMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 615
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
LH E K K L + +E L+ K +D+K + K ++Y ++ +
Sbjct: 616 TALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 977 KRKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 719
Score = 51.6 bits (118), Expect = 2e-05
Identities = 117/511 (22%), Positives = 214/511 (41%), Gaps = 56/511 (10%)
Query: 116 EMENLTK--DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK 173
E E L K D+EIK+ + + K K++ L+EE L + + V E L ++ ++
Sbjct: 199 ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQ 258
Query: 174 NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS--LHIGYDNTLSKLNRSIS 231
+ LT + + +E ++ + A KE Q+ H D ++KL
Sbjct: 259 KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN--E 316
Query: 232 DSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEF 291
DS K+ L ++D EL E S++ E D+ EK+ +
Sbjct: 317 DSQNRQLQQKLAALSRQID-------ELEETNRSLRKAEE-----ELQDIKEKISKGEYG 364
Query: 292 ETKAVKVMSEIKR---NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVF 348
+ + E+++ ++ E+LI E ++ +D R + L D F
Sbjct: 365 NAGIMAEVEELRKRVLDMEGKDEELIKME-EQCRDLNKRLERETLQSKD----------F 413
Query: 349 EILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNIL 408
++ ++ ++K + L+++ + + K + EC S LK EK QL ++ L
Sbjct: 414 KLEVEK-LSKRIMALEKLEDAFNKSK---QECYS-LKCNLEKERMTTKQLSQE------L 462
Query: 409 RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
K RI E+ A+ + K E LKE LTK L+ + +D + + + L KK
Sbjct: 463 ESLKVRIKEL-EAIESRLEKTEFTLKEDLTK-LKTLTVMFVDERKTMSEKL---KKTEDK 517
Query: 469 FDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSL 528
A +Q ++ + EKL ET A D L+ N++K+
Sbjct: 518 LQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLK---NKLKAE 574
Query: 529 HEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK-MLSLSEKDNKLTELVST 587
E+ L S+V+ L ++ + E D LK + ++ K +L +++NK+ EL
Sbjct: 575 EEKGNDLL-SRVNMLKNRLQSLEAI--EKDFLKNKLNQDSGKSTTALHQENNKIKELSQE 631
Query: 588 INGLKEENNSLKSLNDVITREKETQASELER 618
+ LK + +K++ D + + E + LER
Sbjct: 632 VERLKLKLKDMKAIEDDLMK-TEDEYETLER 661
Score = 49.6 bits (113), Expect = 6e-05
Identities = 50/221 (22%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 826 SDSEVSQLKE-RLLSCQQELDDLKERYKELDDECETCAEYL----QERDEQCARLKKEKL 880
S E Q KE R+ + ++EL LK + DE + L Q+ E K+
Sbjct: 213 SQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
Query: 881 SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
L + ++E+ + +E++ + + D+D D + + +K L
Sbjct: 273 KLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-QKLAALS 331
Query: 941 KTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
+ I+EL + L+ ++Q EK +K + E+E+ + + +++ + +EL +
Sbjct: 332 RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E C + K+ E + + K+ K+ V+KLS + +ALEK
Sbjct: 392 MEEQCRDLNKRLERETLQSKDFKLE---VEKLSKRIMALEK 429
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/293 (20%), Positives = 132/293 (45%), Gaps = 28/293 (9%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE- 878
+S +++ E +L +L +Q++ +L KE + +QE +++ RL+KE
Sbjct: 236 KSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL 295
Query: 879 -----KLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE-DWAN--LHSVVVDRMSYD 930
K +Q K Q + Q K A ++ DE + N L +
Sbjct: 296 QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 355
Query: 931 AEVEK----NKRLMKTIEELRYKKQDLKNT---VTKMQ-------KAMEKYTKKDKEFEA 976
++ K N +M +EELR + D++ + KM+ K +E+ T + K+F+
Sbjct: 356 EKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL 415
Query: 977 KRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK 1036
+ ++L LE+L+ + + +EC + L++ K+L + +L++ K +
Sbjct: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK---EL 472
Query: 1037 VALEKQIESLSNTPVSNST-MYVATGSAIVQNQQITDVMKENQ-KLKKMNAKL 1087
A+E ++E T + T + T + + + +++ +K+ + KL+ +++L
Sbjct: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
Score = 39.1 bits (87), Expect = 0.086
Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 26/227 (11%)
Query: 865 LQERDEQCARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
LQ RDE LK EK+ L E Q + + + + ++R A F + ED ++
Sbjct: 83 LQARDEVIGILKAEKMDLALLEAQYGFVTPK-KVLEALQRDA-FQAKSTPWQED---IYE 137
Query: 922 VVVDRMSYDAEVEKNKRLMKTI-EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
++ + D VEK+K + I +L ++ + T+ ++++ EK +K KE+ K E
Sbjct: 138 KPMNEL--DKVVEKHKESYRRILGQLLVAEKSRRQTILELEE--EK--RKHKEYMEKSDE 191
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE-----AKIALEIVD---KL 1032
C E +E ++ K +D+E ++ E +++E++ LKE AL +VD +L
Sbjct: 192 FI-CLLE-QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
Query: 1033 SNQKVALEKQIESL-SNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ Q ++I+ L +N +++ + +A + Q+ T + KE Q
Sbjct: 250 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQ 296
Score = 36.3 bits (80), Expect = 0.61
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 14/188 (7%)
Query: 843 ELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQIRT-QQ 897
EL++ K ++KE ++ + E++ +++C RLKK E S E++ ++++ T ++
Sbjct: 174 ELEEEKRKHKEYMEKSD---EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 898 PVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTV 957
+ + FA + V DE + + R K + + Q+ +
Sbjct: 231 ELTKLKSFALMVV--DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 958 TKMQKAMEKYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQRE 1013
T+++K ++ T K ++ + +L + ++ +L+Q+ L +E E L++ E
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 1014 EQCKRLKE 1021
E+ + +KE
Sbjct: 349 EELQDIKE 356
Score = 32.3 bits (70), Expect = 9.9
Identities = 31/131 (23%), Positives = 60/131 (45%), Gaps = 13/131 (9%)
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRL 1019
++K E Y + + K ELEE K+++KE E+ + E++ E++C+RL
Sbjct: 147 VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSD---EFICLLEQECERL 203
Query: 1020 KEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQ--ITDVMKEN 1077
K +++D+ + E++ E T T + +V QQ + +
Sbjct: 204 K------KLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
Query: 1078 QKLKKM--NAK 1086
QK++++ NAK
Sbjct: 258 QKIQELTTNAK 268
>AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring protein
AKAP350 protein.
Length = 3595
Score = 64.5 bits (150), Expect = 2e-09
Identities = 112/584 (19%), Positives = 249/584 (42%), Gaps = 53/584 (9%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
+++ E+ +++EQ + +N E Q L Q++ + E+ T+ +E++
Sbjct: 1886 IDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKESTTRLQELEQENKLF 1942
Query: 134 KTKSKKINELQEENDTLSN------------LIMENVTESDNLNKEVDDLKKNNECLTQK 181
K +K+ +E+D +S +I E E D LN++V L++ + T
Sbjct: 1943 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2002
Query: 182 CIDLEK--LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ EK L+ + E +I +C +K N + + + + KL + +++ T
Sbjct: 2003 KVIEEKNELIRDLETQIECLMSDQEC-VKRNREEEIE-QLNEVIEKLQQELANIGQKTSM 2060
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
N +L E D+ + + + +++ +E MT + L E N + + +
Sbjct: 2061 NAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF-MKNVLKETNFKMNQLTQEL 2118
Query: 300 SEIKRNLNSLS--EQLINNESKKSKDHIDRYKDSLLAVL--DAEFGTTSLDVFEILMDN- 354
+KR S+ + + N + DH+ + K L VL DA + F+ +N
Sbjct: 2119 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2178
Query: 355 ---IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
IIN + L ++ + +L +C ++K + E+ +++++K+ N+ +I
Sbjct: 2179 KGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKK-IVNLQKIV 2235
Query: 412 KERIHE-ISSAVTIDIVKKENEL---KEILTKECLKLSKLKIDIPRD--LDQDLPAHKKI 465
+E++ + S + ++ V++ + + ++ E + + ++ R+ L D+ A +
Sbjct: 2236 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA---L 2292
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTA-----KAVXXXXXXXXXXXXXXFDTLEE 520
T+ L +Q T +EKE++ + K + +
Sbjct: 2293 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2352
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE---- 576
+ +V+ L + T+L+ S +E + N ++ L E A K +A +EK L E
Sbjct: 2353 SPQDVEVL-KTTTELFHS--NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2409
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSC 620
K+ +T L ++ +++ K ++ +E ET+ E +++C
Sbjct: 2410 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2453
Score = 61.7 bits (143), Expect = 1e-08
Identities = 167/799 (20%), Positives = 326/799 (40%), Gaps = 74/799 (9%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK--EQKSAL 91
N IIE + ++L+D +T + K+ L+E + N +++ + EL + K E++S+
Sbjct: 25 NTKIIEEEKKTLELKDK--LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 82
Query: 92 EGKY-QNLILETQTRDLLMSQ-----IKSLEMENLTKDKEIKNLTDSL------KTKSKK 139
E K + E Q R+ SQ ++ +E E K ++++ D + + K +
Sbjct: 83 EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL 142
Query: 140 INE---LQEENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN- 194
I + EE T MEN S N+ D +K N + + I L+ ++ E
Sbjct: 143 IRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 202
Query: 195 --KIGP--KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD--SNTSTRYNKICT---L 245
++G + CA + E+L++ L + + + ++I++ S + + + T L
Sbjct: 203 KEELGLILEEKCALQRQLEDLVEELSFSREQ-IQRARQTIAEQESKLNEAHKSLSTVEDL 261
Query: 246 QSELDAGREDCKELC----EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK--VM 299
++E+ + E KEL + T+ K LE+ E LD ++ E+ E E + ++ ++
Sbjct: 262 KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD-RMAESQEAELERLRTQLL 320
Query: 300 SEIKRNLNSLSEQL-----INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+ L+ L E L IN E K KD++ + + L E + ++ + DN
Sbjct: 321 FSHEEELSKLKEDLEIEHRINIE--KLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDN 377
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+I K + EI + Q +N + E+ +L L ++E L + +
Sbjct: 378 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 437
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT-----ILF 469
+ + + + +KEN+L+E + + S LK D + L+ L H ++ I
Sbjct: 438 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILK-DEKKTLEDMLKIHTPVSQEERLIFL 496
Query: 470 DALITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHN 523
D++ ++ + S + EIE E L+ + F+ +E
Sbjct: 497 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 556
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E L + L SK + + +K L+EE+ +I + K E + E
Sbjct: 557 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 616
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ ++++ L +V REK + L + +KQ E+ + ++
Sbjct: 617 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV----KS 672
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E + ++ N A Q C+ T+ S L+ + + AE + +
Sbjct: 673 LKQEKEQVSLRCRELEIIINHNRAENVQSCD--TQVSSLLDGVVTMTSRGAE---GSVSK 727
Query: 703 LQKQIQEDDKLFIEKETKLNELT----NKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ K E+ K+ +E + +T +K E L D+ +V ESS A K
Sbjct: 728 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRATQPSENDKLQ 786
Query: 759 VEGRIAELE-SDIRTEQTA 776
E + + E +D+R + A
Sbjct: 787 KELNVLKSEQNDLRLQMEA 805
Score = 60.1 bits (139), Expect = 4e-08
Identities = 185/997 (18%), Positives = 407/997 (40%), Gaps = 71/997 (7%)
Query: 109 MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNK-E 167
++Q S++ ENL ++E + L + L+ K+++ E T++ N N+ E
Sbjct: 1327 LAQRSSIDNENLVSERE-RVLLEELEAL-KQLSLAGREKLCCELRNSSTQTQNGNENQGE 1384
Query: 168 VDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLN 227
V++ + L +K D+ + +E K K+ ++++ + T+ +
Sbjct: 1385 VEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTT-AAVEETIGRHV 1443
Query: 228 RSISDSNTSTRYNKICTLQSELDAGREDC--KELCEDFTSIKNHLELHEPNMTMDLDEKL 285
I D ++ ++ + +SE +A + C +E D SI ++ P +++ K+
Sbjct: 1444 LGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRD-ESIPSYSGSDMPRNDINMWSKV 1502
Query: 286 GENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL 345
E ++ + ++ +E+L+ N S + + +++ +++ + ++ +
Sbjct: 1503 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAI-SETSSQLEHAKV 1561
Query: 346 DVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENAC 405
E++ ++ K E E K Q +L E E E+LA +L + E
Sbjct: 1562 TQTELMRESFRQK-----QEATESL-KCQEELRERLHEESRAREQLAV---ELSKAEGVI 1612
Query: 406 NILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR-DLDQDLPAHKK 464
+ +K + E DI+ + L++ L +L +L+ + + +++L + +K
Sbjct: 1613 DGYADEKT-LFERQIQEKTDIIDR---LEQELLCASNRLQELEAEQQQIQEERELLSRQK 1668
Query: 465 ITILFDALITQYELSRTDYEIEKEKLRLETGTAK-------AVXXXXXXXXXXXXXXFDT 517
+ +A + +L + ++ KEKL ++ K V +
Sbjct: 1669 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKDRDDLQKQVKALEIDVEEQVSRFIEL 1728
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE-EIDALKIAIAKNEEKMLSLSE 576
+E + E+ L ++ L K ++++ L+ I E E D + I K E+++ +
Sbjct: 1729 EQEKNTELMDLRQQNQALEK-QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 1787
Query: 577 ----KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
+++ E+ N LKE+ + L KE +++ + I++ F + +
Sbjct: 1788 FQPISEHQTREVEQLANHLKEKTDKCSEL----LLSKEQLQRDIQERNEEIEKLEFRVRE 1843
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAK---SLLEQNLALKEQCEEKTRDCSRLEINIKTH 689
++ +L+ EAK SL Q A ++ + K ++ + LE ++
Sbjct: 1844 LEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 1903
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+ E +N + +L Q++ K E T+L EL + + K D + ++ S +A+
Sbjct: 1904 REELENKNEEVQQLHMQLEIQKK---ESTTRLQELEQENKLFKDDMEKLGLAIKES-DAM 1959
Query: 750 NQLTTQKDLVEGRIAEL--ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD 807
+ T + ++ G+ A++ E ++ +Q + + RD
Sbjct: 1960 S--TQDQHVLFGKFAQIIQEKEVEIDQ---LNEQVTKLQQQLKITTDNKVIEEKNELIRD 2014
Query: 808 LGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQE 867
L + S + + + E+ QL E + QQEL ++ ++ + +E
Sbjct: 2015 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSM---NAHSLSEEADS 2071
Query: 868 RDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
Q + EKL+LEQQV E++ + V ++ F ++ L S+ +R
Sbjct: 2072 LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF-----KMNQLTQELFSLKRERE 2126
Query: 928 SYD--AEVEKNKRLMKTIEELRYKKQDLKNTVTK-MQKAMEKYTKKDKEFEAKRK-ELED 983
S + + +N + I+ L K +L+ +T+ K++E T K FE K + +
Sbjct: 2127 SVEKIQSIPENS-VNVAIDHLSKDKPELEVVLTEDALKSLENQT-YFKSFEENGKGSIIN 2184
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD--KLSNQKVALEK 1041
+ L +L+ D E C + +K +EQ + + + +IV+ K+ +KVA
Sbjct: 2185 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKKIVNLQKIVEEKVA-AA 2242
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
+ + V + I + T++ NQ
Sbjct: 2243 LVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 2279
Score = 52.8 bits (121), Expect = 7e-06
Identities = 158/729 (21%), Positives = 309/729 (42%), Gaps = 63/729 (8%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 354 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 413
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 414 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 470
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 471 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 530
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+ + + N A+ + N Q L Y L K+ + DS +
Sbjct: 531 EEIEKQRNTFS----FAEKNFEVN-YQELQEEY-ACLLKVKDDLEDSKNKQELE----YK 580
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEI-KR 304
S+L A E+ + T++K + + + T + ++GE E +T + E+ KR
Sbjct: 581 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 640
Query: 305 NLNSLSEQLIN-NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID- 362
LS++L + +E K K + + + L E SL E ++ IIN + +
Sbjct: 641 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE--LEIIINHNRAEN 698
Query: 363 LDEILEKYTKVQGDLNECTS-----ELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
+ + + + + TS + VN+ + ++E + + + + +E E
Sbjct: 699 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 758
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI--TQ 475
+ V KE+ L+ E KL K ++++ + DL + + +L+ T
Sbjct: 759 QLILDHLPSVTKESSLRATQPSENDKLQK-ELNVLKSEQNDLRLQMEAQRICLSLVYSTH 817
Query: 476 YELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
+ R E EK+K L+ E A+ +E +E K LH
Sbjct: 818 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 877
Query: 532 LTKLYKSKVDENNANL-NLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
+ KL K+ +E + L L +L E ALK + +++ +N+ EL
Sbjct: 878 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 937
Query: 590 GLKEENNSLKSLNDVITRE------KETQASEL--ERSCQVIKQNGFE-LDKMKADILMX 640
+++ ++ +L + +T E +T+ S++ +++ + + G E L K + + L
Sbjct: 938 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 997
Query: 641 XXXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ SL + + L+EQ +E S L+ +K E+ E +
Sbjct: 998 HSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE--- 1054
Query: 700 IMRLQKQIQ 708
I LQK++Q
Sbjct: 1055 IHCLQKRLQ 1063
Score = 52.4 bits (120), Expect = 9e-06
Identities = 117/637 (18%), Positives = 255/637 (40%), Gaps = 44/637 (6%)
Query: 280 DLDEKLGENNEFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDA 338
+L ++ ++++FET V+ M E +R L L +L + I + K L+ A
Sbjct: 93 ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHMA 148
Query: 339 EFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQ 397
+ + M+N + Y I ++E K V +NE +L+ N + L +
Sbjct: 149 QMEEMKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKEE 205
Query: 398 L-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
L + E C + R ++ + E+S S I ++ +E E K D+ ++
Sbjct: 206 LGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 265
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXF 515
+ K++ + +A +T Y++ +EKEK + A++
Sbjct: 266 VSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLRT------ 317
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 318 QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF-- 373
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 374 EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQ 433
Query: 636 DI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTHE 690
++ L ++ L +N LK+ E+KT D ++ + E
Sbjct: 434 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQEE 491
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESSR 746
+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 492 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 551
Query: 747 EAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXXX 799
+ + + L KD +E + E + +++ A +
Sbjct: 552 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 611
Query: 800 TFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECE 859
TF E ++GE + D + ++ E +L +RL ++ LK+++ E+ E
Sbjct: 612 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLNE 668
Query: 860 TCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
QE+++ R ++ ++ + + + TQ
Sbjct: 669 EVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 705
Score = 51.2 bits (117), Expect = 2e-05
Identities = 107/566 (18%), Positives = 236/566 (41%), Gaps = 46/566 (8%)
Query: 544 NANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING-LKEENNSLKSLN 602
N+N I+ I+ L I + E+K L L +K +L+ + + ++N +K++
Sbjct: 8 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 67
Query: 603 DVIT--REKETQASE----LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD 656
+T ++KE Q+SE L + + +++ + + + DI+
Sbjct: 68 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA-- 125
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
E + Q + +Q E + +++E +KT K E++N + + ED +
Sbjct: 126 ELDEMYGQQIVQMKQ-ELIRQHMAQME-EMKTRHK-GEMENALRSYSNITVNEDQIKLMN 182
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVEGRIAELESDIRTEQT 775
+NEL K + + ++L E L Q +DLVE E R QT
Sbjct: 183 --VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT 240
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
DL ++ + + ++EV+ K
Sbjct: 241 IAEQESKLNEAHKSLSTV------------EDLKAEIVSASESRKELELKHEAEVTNYKI 288
Query: 836 RLLSCQQELDDLKERYKELDD-ECETC-AEYLQERDEQCARLKKEKLSLEQQVS--NLKE 891
+L ++E + + +R E + E E + L +E+ ++LK E L +E +++ LK+
Sbjct: 289 KLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLK-EDLEIEHRINIEKLKD 347
Query: 892 QIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQ 951
+ + +++ + +++ + E+ K K L +++ + K +
Sbjct: 348 NLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL--VNSKSE 405
Query: 952 DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
++ + ++QK +E +++KE +E+++ + + E L+++ KE + + + E Q
Sbjct: 406 EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ---EKFAQ 462
Query: 1012 REEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT 1071
E + LK+ K LE + K+ + V+ E+++ L + + V ++I
Sbjct: 463 LEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSKSKDS--------VWEKEIE 513
Query: 1072 DVMKENQKLKKMNAKLITICKKRGKT 1097
+++EN+ LK+ +L +K+ T
Sbjct: 514 ILIEENEDLKQQCIQLNEEIEKQRNT 539
Score = 50.0 bits (114), Expect = 5e-05
Identities = 54/263 (20%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 849 ERYKELDDECETCAEY-LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF 905
+R +E + + EY +Q++ Q ++ E S++ + + L+EQ+ +++ V E +++
Sbjct: 2797 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 2856
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
A + + H + + ++ EV+ + + + +Q ++Q A+E
Sbjct: 2857 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR---ELQWALE 2913
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQREEQCKRLKE 1021
K K + E ++ELED K LE KQR +L+ E+ + +Q+ E + L +
Sbjct: 2914 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYD 2973
Query: 1022 AKIA------LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVM 1074
A+++ LE+ L ++KV + + +L ++ + + G+ + D++
Sbjct: 2974 AQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 3033
Query: 1075 KENQK-LKKMNAKLITICKKRGK 1096
KE QK L++ +++++ + + K
Sbjct: 3034 KELQKQLEEKHSRIVELLNETEK 3056
Score = 48.0 bits (109), Expect = 2e-04
Identities = 74/334 (22%), Positives = 141/334 (42%), Gaps = 19/334 (5%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT 121
S+K+ + E+ E+LS E + E KS L L + + + ++++ +E
Sbjct: 2830 SMKDRATELQ---EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 2886
Query: 122 KDKEIKNLTDSLKTKSKKINELQ----EENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
K E+ L D+L ++ KK ELQ +E L + E ++L ++ K+ N
Sbjct: 2887 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 2946
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L ++L+NES+ KI + + +L E ++L + K+ R S+T
Sbjct: 2947 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV-RIREMSSTLD 3005
Query: 238 RYNKI-CTLQSELDAGREDCKELCED-FTSIKNHLELHEPNMTMDLDEKLGENNEFETKA 295
R ++ LQS G+ ED ++ LE + L+E E + ++
Sbjct: 3006 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET--EKYKLDSLQ 3063
Query: 296 VKVMSEIKRNLNS---LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLDVFEIL 351
+ E R ++ +EQ N E +K + + L L+ + LD+
Sbjct: 3064 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 3123
Query: 352 MDNIINKYQ---IDLDEILEKYTKVQGDLNECTS 382
+ I+ ++Q ++ +E E + +LNE T+
Sbjct: 3124 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 3157
Score = 47.6 bits (108), Expect = 2e-04
Identities = 114/563 (20%), Positives = 229/563 (40%), Gaps = 67/563 (11%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALK-IAIAKNEEKMLSLSEK 577
E+ E+K L+ +L + +S +D N ++L EE++ALK +++A E+ L
Sbjct: 1314 EQLQEEIKRLNRQLAQ--RSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNS 1371
Query: 578 DNKLTELVSTINGLKEENNSLKSLN----DVITREKETQASELERSCQVIKQNGFELDKM 633
+ ++E+ K L+ DV + L+++ + + E+ K
Sbjct: 1372 STQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKT 1431
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLL--EQNLALKEQC--EEKTRDCS--------- 680
A + + SL+ + A + C EE TRD S
Sbjct: 1432 TAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRDESIPSYSGSDM 1491
Query: 681 -RLEINI--KTHEKTAEIQNRMIMR--LQKQIQ-EDDKLFIEKETKLNELTNK-YEALKR 733
R +IN+ K E+ E+ R++ +I E+++L + ++L K EA+
Sbjct: 1492 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1551
Query: 734 DYD----AAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXX 789
A V E RE+ Q + ++ + EL + E A
Sbjct: 1552 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSKAEG 1610
Query: 790 XXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
F R + E + D ++ + + + + + +L+ Q+E + L
Sbjct: 1611 VIDGYADEKTLF---ERQIQEKTDIIDRLEQEL-LCASNRLQELEAEQQQIQEERELLSR 1666
Query: 850 RYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA 909
+ + + E + L + E +L KEKL ++ Q + + +++Q K ++
Sbjct: 1667 QKEAMKAEAGPVEQQLLQETE---KLMKEKLEVQCQAE------KDRDDLQKQVKALEID 1717
Query: 910 VNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAM-EKYT 968
V V R + E EKN LM +LR + Q L+ + KM+K + E+
Sbjct: 1718 VEEQ----------VSRF-IELEQEKNTELM----DLRQQNQALEKQLEKMRKFLDEQAI 1762
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDE----ECETCAEYLKQREEQCKRLKEAKI 1024
++ E + ++E++ + +L ++ R++ + E E E A +LK++ ++C L +K
Sbjct: 1763 DREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 1821
Query: 1025 ALEIVDKLSNQKV-ALEKQIESL 1046
L+ + N+++ LE ++ L
Sbjct: 1822 QLQRDIQERNEEIEKLEFRVREL 1844
Score = 46.8 bits (106), Expect = 4e-04
Identities = 108/523 (20%), Positives = 224/523 (42%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 54 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 112
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 113 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNI 171
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 172 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 231
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 232 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 291
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L TQ E +++L+ D+ E +
Sbjct: 292 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 351
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 352 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 407
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 408 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 462
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 463 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 522
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 523 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 565
Score = 44.8 bits (101), Expect = 0.002
Identities = 120/645 (18%), Positives = 265/645 (41%), Gaps = 67/645 (10%)
Query: 368 EKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIV 427
E+ KV+ E E +++ E+L N+++IE+E K+ + T D
Sbjct: 1 EQDKKVENSNKEEIQEKETIIEEL---NTKIIEEE---------KKTLELKDKLTTAD-- 46
Query: 428 KKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEK 487
K EL+E + ++ ++ +K+++ ++ + ++I L + + + D + E
Sbjct: 47 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 106
Query: 488 EKL-RLETGTAKAVXXXXXXXXXXXXXXFDTL-EEAHNEVKSLHEELTKLYKSKVDENNA 545
+ + R+E T + + + +E + + EE+ +K +++
Sbjct: 107 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 166
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVI 605
+ + I + ++I + +AI + K+ + + KL E + I L+E+ + L D++
Sbjct: 167 SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLI--LEEKCALQRQLEDLV 224
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
E +++R+ Q I + +L++ + E++ LE
Sbjct: 225 -EELSFSREQIQRARQTIAEQESKLNEAHKSL-----STVEDLKAEIVSASESRKELE-- 276
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNEL 724
LK + E ++++ + EK A + +RM + +++ +L E +L++L
Sbjct: 277 --LKHEAEVTN---YKIKLEMLEKEKNA-VLDRMAESQEAELERLRTQLLFSHEEELSKL 330
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
E R +KD N K ++G E+ I T Q
Sbjct: 331 KEDLEIEHRINIEKLKD--------NLGIHYKQQIDGLQNEMSQKIETMQ-------FEK 375
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL-SCQQE 843
D + L N K ++ + + + E+ + +E+ + +QE
Sbjct: 376 DNLITKQNQLILEISKLKDLQQSL-VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 434
Query: 844 LDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQA 903
+ +L+ + + L+ + + LQE+ A+L+ E L+ + L++ ++ PV ++
Sbjct: 435 VQELQLKTELLEKQMKEKENDLQEK---FAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 491
Query: 904 K--FADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQ 961
+ F D + +D V + +E+N+ L + +L + + +NT + +
Sbjct: 492 RLIFLDSIKSKSKD-------SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 544
Query: 962 KAME-KYTKKDKEFEAKRK---ELEDCKAELE-ELKQRYKELDEE 1001
K E Y + +E+ K +LED K + E E K + K L+EE
Sbjct: 545 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 589
Score = 44.4 bits (100), Expect = 0.002
Identities = 60/256 (23%), Positives = 110/256 (42%), Gaps = 20/256 (7%)
Query: 64 KESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKD 123
++ S I L+ EK + EL D+++Q ALE + + + R L Q E E
Sbjct: 1720 EQVSRFIELEQEK-NTELMDLRQQNQALEKQLEKM------RKFLDEQAIDREHERDVFQ 1772
Query: 124 KEIKNLTDSLKT--KSKKINELQ-EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+EI+ L LK + + I+E Q E + L+N + E + L + L+++ + +
Sbjct: 1773 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 1832
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI---SDSNTST 237
+ LE V E E + + + H G +L+ + ++ +
Sbjct: 1833 EIEKLEFRVRELEQAL-----LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAID 1887
Query: 238 RYNK-ICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV 296
R K I L+ +L+ RE+ + E+ + LE+ + T L E EN F+
Sbjct: 1888 RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDME 1947
Query: 297 KVMSEIKRNLNSLSEQ 312
K+ IK + +++S Q
Sbjct: 1948 KLGLAIKES-DAMSTQ 1962
Score = 43.6 bits (98), Expect = 0.004
Identities = 77/399 (19%), Positives = 190/399 (47%), Gaps = 28/399 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEI-- 126
E +++++L+ ++ +++Q L+ N ++E + L+ +++ ++E L D+E
Sbjct: 1977 EKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEKNE--LIRDLET-QIECLMSDQECVK 2030
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+N + ++ ++ I +LQ+E L+N+ + + +L++E D LK + + + + LE
Sbjct: 2031 RNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2087
Query: 187 KLV-NESENKIGPKNICAQCKLKEN-LIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ V +E KN+ + K N L Q L + + + +SI +++ + + +
Sbjct: 2088 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 2147
Query: 244 TLQSELDAG-REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ EL+ ED + E+ T K+ E + ++L+ +L + + +++
Sbjct: 2148 KDKPELEVVLTEDALKSLENQTYFKS-FEENGKGSIINLETRLLQLESTVSAKDLELTQC 2206
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYK---DSLLAVLDAEFGTTSLDVF-EILMDNIINK 358
+ + + EQ K ++ K + + A L ++ ++ + + DN
Sbjct: 2207 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 2266
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + I + +++ D E S++ ++ +++ L SQ++E + L ++KE++ EI
Sbjct: 2267 SEPERTNI-QNLNQLRED--ELGSDISALTLRISELESQVVEMHTS---LILEKEQV-EI 2319
Query: 419 SSAVTIDIVKKENELKEILT-KECLKLSKLKIDIPRDLD 456
+ ++ KK EL+++L E + K K P+D++
Sbjct: 2320 AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2358
Score = 43.2 bits (97), Expect = 0.005
Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 58/420 (13%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR---DLLMSQIKSLEMEN 119
+K E N K+ +L+ ELF +K ++ ++E K Q+ I E D L LE+
Sbjct: 2100 MKNVLKETNFKMNQLTQELFSLKRERESVE-KIQS-IPENSVNVAIDHLSKDKPELEVV- 2156
Query: 120 LTKD--KEIKNLT--DSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKK- 173
LT+D K ++N T S + K I L+ L + + E K++ D+++
Sbjct: 2157 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2216
Query: 174 ---NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI 230
E L +K ++L+K+V E K+ L+ + + + + +
Sbjct: 2217 GQFETEMLQKKIVNLQKIVEE--------------KVAAALVSQIQL---EAVQEYAKFC 2259
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
D+ T + + +Q+ L+ RED EL D +++ + E + +++ L E
Sbjct: 2260 QDNQTISSEPERTNIQN-LNQLRED--ELGSDISALTLRISELE-SQVVEMHTSLILEKE 2315
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
A K + E ++ L L + L NE K+ R K+ + D E T+ ++F
Sbjct: 2316 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ------REKEKKRSPQDVEVLKTTTELFH- 2368
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
N + + +L+ + + + +EL S EK L +L+ KE N+ +
Sbjct: 2369 --SNEESGFFNELEALRAESVATK-------AELASYKEKAEKLQEELLVKET--NMTSL 2417
Query: 411 QKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
QK+ R H + + I++KE+E + +K+ L I + + + KI+
Sbjct: 2418 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2477
Score = 43.2 bits (97), Expect = 0.005
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 25/380 (6%)
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRM------IMRLQKQIQEDDKLFIE 716
+ + LK + E + LE NI+ + + E+Q + LQ+Q+ + + E
Sbjct: 2792 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 2851
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+++L + + E + +K+LE+ R V T + L+ +A + R Q A
Sbjct: 2852 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 2911
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+ F E++ N +L+ ++ ++++S+ +R
Sbjct: 2912 -LEKEKAKLGRSEERDKEELEDLKFSLESQK-QRNLQLNLLLEQQKQLLNESQQKIESQR 2969
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+L +L + + R EL E +E ++ R+ ++ +L + Q S+ Q R
Sbjct: 2970 ML-YDAQLSEEQGRNLELQVLLE--SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 3026
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKN 955
P E D+ + HS +V+ ++ E EK K ++T +++ +Q +
Sbjct: 3027 LPSE------DLLKELQKQLEEKHSRIVELLN---ETEKYKLDSLQTRQQMEKDRQVHRK 3077
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T+ Q+A + KK E ++K +ED + +LEE +Q+ +LD E + +++ ++Q
Sbjct: 3078 TLQTEQEANTEGQKKMHELQSK---VEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ 3134
Query: 1016 CKRLKEAKIALEIVDKLSNQ 1035
+E + + I+ + N+
Sbjct: 3135 ELEREEKRESRRILYQNLNE 3154
Score = 36.7 bits (81), Expect = 0.46
Identities = 45/277 (16%), Positives = 117/277 (42%), Gaps = 11/277 (3%)
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
KE + + +++L + E + + + L D+ L+++ + Q++ N+K ++
Sbjct: 11 KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLEL 70
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDL 953
+ ERQ+ + + + + D + + +E+LR + ++
Sbjct: 71 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 130
Query: 954 --KNTVTKMQKAMEKYTKKDKEFEAKRK-ELEDCKAELEEL---KQRYKELDEECETCAE 1007
+ V Q+ + ++ + +E + + K E+E+ + + + K ++
Sbjct: 131 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 190
Query: 1008 YLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQN 1067
L+ Q ++LKE ++ L + +K + Q+ LE +E LS S + A + Q
Sbjct: 191 KLQDTNSQKEKLKE-ELGLILEEKCALQR-QLEDLVEELS---FSREQIQRARQTIAEQE 245
Query: 1068 QQITDVMKENQKLKKMNAKLITICKKRGKTGANRENE 1104
++ + K ++ + A++++ + R + E E
Sbjct: 246 SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAE 282
>AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein.
Length = 2058
Score = 64.5 bits (150), Expect = 2e-09
Identities = 112/584 (19%), Positives = 249/584 (42%), Gaps = 53/584 (9%)
Query: 74 LEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
+++ E+ +++EQ + +N E Q L Q++ + E+ T+ +E++
Sbjct: 408 IDRKEKEITNLEEQLEQFREELENKNEEVQQ---LHMQLEIQKKESTTRLQELEQENKLF 464
Query: 134 KTKSKKINELQEENDTLSN------------LIMENVTESDNLNKEVDDLKKNNECLTQK 181
K +K+ +E+D +S +I E E D LN++V L++ + T
Sbjct: 465 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 524
Query: 182 CIDLEK--LVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ EK L+ + E +I +C +K N + + + + KL + +++ T
Sbjct: 525 KVIEEKNELIRDLETQIECLMSDQEC-VKRNREEEIE-QLNEVIEKLQQELANIGQKTSM 582
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
N +L E D+ + + + +++ +E MT + L E N + + +
Sbjct: 583 NAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF-MKNVLKETNFKMNQLTQEL 640
Query: 300 SEIKRNLNSLS--EQLINNESKKSKDHIDRYKDSLLAVL--DAEFGTTSLDVFEILMDN- 354
+KR S+ + + N + DH+ + K L VL DA + F+ +N
Sbjct: 641 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 700
Query: 355 ---IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
IIN + L ++ + +L +C ++K + E+ +++++K+ N+ +I
Sbjct: 701 KGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKK-IVNLQKIV 757
Query: 412 KERIHE-ISSAVTIDIVKKENEL---KEILTKECLKLSKLKIDIPRD--LDQDLPAHKKI 465
+E++ + S + ++ V++ + + ++ E + + ++ R+ L D+ A +
Sbjct: 758 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA---L 814
Query: 466 TILFDALITQYELSRTDYEIEKEKLRLETGTA-----KAVXXXXXXXXXXXXXXFDTLEE 520
T+ L +Q T +EKE++ + K + +
Sbjct: 815 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 874
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSE---- 576
+ +V+ L + T+L+ S +E + N ++ L E A K +A +EK L E
Sbjct: 875 SPQDVEVL-KTTTELFHS--NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 931
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSC 620
K+ +T L ++ +++ K ++ +E ET+ E +++C
Sbjct: 932 KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 975
Score = 59.7 bits (138), Expect = 6e-08
Identities = 112/572 (19%), Positives = 234/572 (40%), Gaps = 39/572 (6%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
L + + ++L ++L K+ K ++ + + +EI L+ + K + +SE
Sbjct: 258 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEH 316
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
+ E ++ N LKE+ + L KE +++ + I++ F + +++ +
Sbjct: 317 QTREVEQLA--NHLKEKTDKCSEL----LLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 370
Query: 638 LMXXXXXXXXXXXXXXXXDEAK---SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAE 694
L+ EAK SL Q A ++ + K ++ + LE ++ + E
Sbjct: 371 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 430
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
+N + +L Q++ K E T+L EL + + K D + ++ S +A++ T
Sbjct: 431 NKNEEVQQLHMQLEIQKK---ESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMS--TQ 484
Query: 755 QKDLVEGRIAEL--ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ ++ G+ A++ E ++ +Q + + RDL
Sbjct: 485 DQHVLFGKFAQIIQEKEVEIDQ---LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI 541
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ S + + + E+ QL E + QQEL ++ ++ + +E Q
Sbjct: 542 ECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSM---NAHSLSEEADSLKHQL 598
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD-- 930
+ EKL+LEQQV E++ + V ++ F ++ L S+ +R S +
Sbjct: 599 DVVIAEKLALEQQVETANEEMTFMKNVLKETNF-----KMNQLTQELFSLKRERESVEKI 653
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTK-MQKAMEKYTKKDKEFEAKRK-ELEDCKAEL 988
+ +N + I+ L K +L+ +T+ K++E T K FE K + + + L
Sbjct: 654 QSIPENS-VNVAIDHLSKDKPELEVVLTEDALKSLENQT-YFKSFEENGKGSIINLETRL 711
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD--KLSNQKVALEKQIESL 1046
+L+ D E C + +K +EQ + + + +IV+ K+ +KVA + +
Sbjct: 712 LQLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKKIVNLQKIVEEKVA-AALVSQI 769
Query: 1047 SNTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
V + I + T++ NQ
Sbjct: 770 QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 801
Score = 50.0 bits (114), Expect = 5e-05
Identities = 54/263 (20%), Positives = 126/263 (47%), Gaps = 18/263 (6%)
Query: 849 ERYKELDDECETCAEY-LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV--ERQAKF 905
+R +E + + EY +Q++ Q ++ E S++ + + L+EQ+ +++ V E +++
Sbjct: 1319 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 1378
Query: 906 ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME 965
A + + H + + ++ EV+ + + + +Q ++Q A+E
Sbjct: 1379 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR---ELQWALE 1435
Query: 966 KYTKK-DKEFEAKRKELEDCKAELEELKQRYKELD---EECETCAEYLKQREEQCKRLKE 1021
K K + E ++ELED K LE KQR +L+ E+ + +Q+ E + L +
Sbjct: 1436 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYD 1495
Query: 1022 AKIA------LEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVM 1074
A+++ LE+ L ++KV + + +L ++ + + G+ + D++
Sbjct: 1496 AQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 1555
Query: 1075 KENQK-LKKMNAKLITICKKRGK 1096
KE QK L++ +++++ + + K
Sbjct: 1556 KELQKQLEEKHSRIVELLNETEK 1578
Score = 48.0 bits (109), Expect = 2e-04
Identities = 74/334 (22%), Positives = 141/334 (42%), Gaps = 19/334 (5%)
Query: 62 SLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLT 121
S+K+ + E+ E+LS E + E KS L L + + + ++++ +E
Sbjct: 1352 SMKDRATELQ---EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 1408
Query: 122 KDKEIKNLTDSLKTKSKKINELQ----EENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
K E+ L D+L ++ KK ELQ +E L + E ++L ++ K+ N
Sbjct: 1409 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 1468
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
L ++L+NES+ KI + + +L E ++L + K+ R S+T
Sbjct: 1469 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV-RIREMSSTLD 1527
Query: 238 RYNKI-CTLQSELDAGREDCKELCED-FTSIKNHLELHEPNMTMDLDEKLGENNEFETKA 295
R ++ LQS G+ ED ++ LE + L+E E + ++
Sbjct: 1528 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET--EKYKLDSLQ 1585
Query: 296 VKVMSEIKRNLNS---LSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT-SLDVFEIL 351
+ E R ++ +EQ N E +K + + L L+ + LD+
Sbjct: 1586 TRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQR 1645
Query: 352 MDNIINKYQ---IDLDEILEKYTKVQGDLNECTS 382
+ I+ ++Q ++ +E E + +LNE T+
Sbjct: 1646 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTT 1679
Score = 47.2 bits (107), Expect = 3e-04
Identities = 99/506 (19%), Positives = 202/506 (39%), Gaps = 47/506 (9%)
Query: 566 KNEEKMLSLSEKDNKLTE-LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
+NEE ML++S + E L+ I+ + K + RE Q E S + +
Sbjct: 48 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 107
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L + DE K+L E+ Q +EKT RLE
Sbjct: 108 ELRERLHEESRAREQLAVELSKAEGVIDGYADE-KTLFER------QIQEKTDIIDRLEQ 160
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI-EKETKLNELTNKYEALKRDYDAAVKDLE 743
+ A + + + Q+QIQE+ +L +KE E + L ++ + +K+
Sbjct: 161 ELLC----ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE-- 214
Query: 744 SSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
E Q +D ++ ++ LE D+ + + + +
Sbjct: 215 -KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 273
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
+ R + +D +R + E+ +L+++L + E E E A
Sbjct: 274 KMRKFLDEQAIDREHERDVF---QQEIQKLEQQL-KVVPRFQPISEHQTR---EVEQLAN 326
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+L+E+ ++C+ L K L++ + E+I + +E + + + A+ A+ V
Sbjct: 327 HLKEKTDKCSELLLSKEQLQRDIQERNEEI---EKLEFRVRELEQALLVS---ADTFQKV 380
Query: 924 VDRMSYDA-----EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
DR + A E+ +L + + K++++ N ++++ E+ K++E +
Sbjct: 381 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 440
Query: 979 KELEDCKAE----LEELKQRYKELDEECETCAEYLKQRE---EQCKRLKEAKIALEI--- 1028
+LE K E L+EL+Q K ++ E +K+ + Q + + K A I
Sbjct: 441 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK 500
Query: 1029 ---VDKLSNQKVALEKQIESLSNTPV 1051
+D+L+ Q L++Q++ ++ V
Sbjct: 501 EVEIDQLNEQVTKLQQQLKITTDNKV 526
Score = 46.0 bits (104), Expect = 8e-04
Identities = 64/282 (22%), Positives = 118/282 (41%), Gaps = 20/282 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+E Q K++D + ++ S I L+ EK + EL D+++Q ALE + +
Sbjct: 216 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK-NTELMDLRQQNQALEKQLEK 274
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT--KSKKINELQ-EENDTLSNLI 154
+ R L Q E E +EI+ L LK + + I+E Q E + L+N +
Sbjct: 275 M------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 328
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
E + L + L+++ + ++ LE V E E + + +
Sbjct: 329 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-----LVSADTFQKVEDR 383
Query: 215 LHIGYDNTLSKLNRSI---SDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHL 270
H G +L+ + ++ + R K I L+ +L+ RE+ + E+ + L
Sbjct: 384 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 443
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ + T L E EN F+ K+ IK + +++S Q
Sbjct: 444 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMSTQ 484
Score = 43.6 bits (98), Expect = 0.004
Identities = 77/399 (19%), Positives = 190/399 (47%), Gaps = 28/399 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEI-- 126
E +++++L+ ++ +++Q L+ N ++E + L+ +++ ++E L D+E
Sbjct: 499 EKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEKNE--LIRDLET-QIECLMSDQECVK 552
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+N + ++ ++ I +LQ+E L+N+ + + +L++E D LK + + + + LE
Sbjct: 553 RNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 609
Query: 187 KLV-NESENKIGPKNICAQCKLKEN-LIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ V +E KN+ + K N L Q L + + + +SI +++ + + +
Sbjct: 610 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 669
Query: 244 TLQSELDAG-REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ EL+ ED + E+ T K+ E + ++L+ +L + + +++
Sbjct: 670 KDKPELEVVLTEDALKSLENQTYFKS-FEENGKGSIINLETRLLQLESTVSAKDLELTQC 728
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYK---DSLLAVLDAEFGTTSLDVF-EILMDNIINK 358
+ + + EQ K ++ K + + A L ++ ++ + + DN
Sbjct: 729 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 788
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + I + +++ D E S++ ++ +++ L SQ++E + L ++KE++ EI
Sbjct: 789 SEPERTNI-QNLNQLRED--ELGSDISALTLRISELESQVVEMHTS---LILEKEQV-EI 841
Query: 419 SSAVTIDIVKKENELKEILT-KECLKLSKLKIDIPRDLD 456
+ ++ KK EL+++L E + K K P+D++
Sbjct: 842 AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 880
Score = 43.2 bits (97), Expect = 0.005
Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 58/420 (13%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR---DLLMSQIKSLEMEN 119
+K E N K+ +L+ ELF +K ++ ++E K Q+ I E D L LE+
Sbjct: 622 MKNVLKETNFKMNQLTQELFSLKRERESVE-KIQS-IPENSVNVAIDHLSKDKPELEVV- 678
Query: 120 LTKD--KEIKNLT--DSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKK- 173
LT+D K ++N T S + K I L+ L + + E K++ D+++
Sbjct: 679 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 738
Query: 174 ---NNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI 230
E L +K ++L+K+V E K+ L+ + + + + +
Sbjct: 739 GQFETEMLQKKIVNLQKIVEE--------------KVAAALVSQIQL---EAVQEYAKFC 781
Query: 231 SDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNE 290
D+ T + + +Q+ L+ RED EL D +++ + E + +++ L E
Sbjct: 782 QDNQTISSEPERTNIQN-LNQLRED--ELGSDISALTLRISELE-SQVVEMHTSLILEKE 837
Query: 291 FETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEI 350
A K + E ++ L L + L NE K+ R K+ + D E T+ ++F
Sbjct: 838 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQ------REKEKKRSPQDVEVLKTTTELFH- 890
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
N + + +L+ + + + +EL S EK L +L+ KE N+ +
Sbjct: 891 --SNEESGFFNELEALRAESVATK-------AELASYKEKAEKLQEELLVKET--NMTSL 939
Query: 411 QKE----RIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
QK+ R H + + I++KE+E + +K+ L I + + + KI+
Sbjct: 940 QKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 999
Score = 43.2 bits (97), Expect = 0.005
Identities = 77/380 (20%), Positives = 165/380 (43%), Gaps = 25/380 (6%)
Query: 664 QNLALKEQCEEKTRDCSRLEINIKTHE-KTAEIQNRM------IMRLQKQIQEDDKLFIE 716
+ + LK + E + LE NI+ + + E+Q + LQ+Q+ + + E
Sbjct: 1314 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 1373
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+++L + + E + +K+LE+ R V T + L+ +A + R Q A
Sbjct: 1374 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 1433
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+ F E++ N +L+ ++ ++++S+ +R
Sbjct: 1434 -LEKEKAKLGRSEERDKEELEDLKFSLESQK-QRNLQLNLLLEQQKQLLNESQQKIESQR 1491
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
+L +L + + R EL E +E ++ R+ ++ +L + Q S+ Q R
Sbjct: 1492 ML-YDAQLSEEQGRNLELQVLLE--SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPP 1548
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKN 955
P E D+ + HS +V+ ++ E EK K ++T +++ +Q +
Sbjct: 1549 LPSE------DLLKELQKQLEEKHSRIVELLN---ETEKYKLDSLQTRQQMEKDRQVHRK 1599
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T+ Q+A + KK E ++K +ED + +LEE +Q+ +LD E + +++ ++Q
Sbjct: 1600 TLQTEQEANTEGQKKMHELQSK---VEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ 1656
Query: 1016 CKRLKEAKIALEIVDKLSNQ 1035
+E + + I+ + N+
Sbjct: 1657 ELEREEKRESRRILYQNLNE 1676
Score = 40.3 bits (90), Expect = 0.037
Identities = 101/520 (19%), Positives = 208/520 (40%), Gaps = 38/520 (7%)
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN--SLSEQLI 314
++L E + + LE + T + E + E T+++K E++ L+ S + + +
Sbjct: 65 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-ATESLKCQEELRERLHEESRAREQL 123
Query: 315 NNESKKSKDHIDRYKDS-LLAVLDAEFGTTSLDVFE---ILMDNIINKYQIDLDEILEKY 370
E K++ ID Y D L + T +D E + N + + + + +I E+
Sbjct: 124 AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER 183
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEISSAVTIDIVK 428
+ +E V ++L +L+++ E C +++ + ++ A+ ID+ +
Sbjct: 184 ELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVK-ALEIDVEE 242
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
+ + E+ ++ +L L+ + L++ L +K D E R ++ E +
Sbjct: 243 QVSRFIELEQEKNTELMDLRQQ-NQALEKQLEKMRKF---LDEQAIDREHERDVFQQEIQ 298
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
KL + + L+E ++ L +L + + E N +
Sbjct: 299 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD-IQERNEEIE 357
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR- 607
++ E++ + A +K+ +D K V L E L++ D I R
Sbjct: 358 KLEFRVRELEQALLVSADTFQKV-----EDRKHFGAVEAKPELSLEVQ-LQAERDAIDRK 411
Query: 608 EKE-TQASE-LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ- 664
EKE T E LE+ + ++ E+ ++ + + K +E+
Sbjct: 412 EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 471
Query: 665 NLALKEQCEEKTRDCSRL--EINIKTHEKTAEIQ--NRMIMRLQKQ---------IQEDD 711
LA+KE T+D L + EK EI N + +LQ+Q I+E +
Sbjct: 472 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 531
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ 751
+L + ET++ L + E +KR+ + ++ L E + Q
Sbjct: 532 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ 571
>BC051733-1|AAH51733.1| 1026|Homo sapiens LUZP1 protein protein.
Length = 1026
Score = 64.1 bits (149), Expect = 3e-09
Identities = 85/353 (24%), Positives = 151/353 (42%), Gaps = 24/353 (6%)
Query: 66 SSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE 125
SS + KL+ LS L +++E L+ K ++ +L+ Q + + E N + E
Sbjct: 12 SSRHLRFKLQSLSRRLDELEEATKNLQ-KAEDELLDLQDK------VIQAEGSNSSMLAE 64
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I+ L + K E++ D L L+ E + E +NL +E LK E L ++ +L
Sbjct: 65 IEVLRQRVLRIEGKDEEIKRAED-LCRLMKEKLEEEENLTRE---LKSEIERLQKRMAEL 120
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
EKL E+ ++ KN C Q L N ++L + L L + + +S +++
Sbjct: 121 EKL-EEAFSR--SKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE--DRLDKT 175
Query: 246 QSELDAGREDCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ L + E K L F S + +L E + +L +KL +N + + S +
Sbjct: 176 EQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+RN + + + + + SK+ R K L + E T + E + NK + D
Sbjct: 236 ERNDLRIEDGI--SSTLPSKE--SRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK-D 290
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
L++ +EK ELK + K L + ++N +L Q E I
Sbjct: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
Score = 52.8 bits (121), Expect = 7e-06
Identities = 62/263 (23%), Positives = 118/263 (44%), Gaps = 23/263 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
+E E+K E+L +L K K++E NL + L EI+ L+ +A+ E+ + S
Sbjct: 75 IEGKDEEIKRA-EDLCRLMKEKLEEEE---NLTRELKSEIERLQKRMAELEKLEEAFSRS 130
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVI----TREKETQASELERSCQVIKQNGFELDKM 633
N T+L ++N EE N K ++ + + KE ++SE +R + + EL+K+
Sbjct: 131 KNDCTQLCLSLN---EERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQSLASELEKL 186
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN-------I 686
K+ L K L ++ K+ + TR+ S LE N I
Sbjct: 187 KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGI 246
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLE 743
+ + E + + + KQ++ + + E E N+ NK + L ++ + +K E
Sbjct: 247 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
Query: 744 SSREAVNQLTTQ-KDLVEGRIAE 765
S E + ++ ++ DL + ++E
Sbjct: 307 SLEEELKKMKSKNNDLQDNYLSE 329
Score = 47.6 bits (108), Expect = 2e-04
Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 6/194 (3%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS-LEQQVS 887
E+ ++RL +Q L E+ K L + +YL E++++ +L KE LEQ
Sbjct: 164 ELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKK 223
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
++ R +ER + +++ + S + Y +VE R K+ E
Sbjct: 224 MNRDYTRNASNLERNDLRIEDGISST--LPSKESRRKGGLDYLKQVENETR-NKSENEKN 280
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
++D N V + + +EK + K FE+ +EL+ K++ +L+ Y + + A
Sbjct: 281 RNQED--NKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Query: 1008 YLKQREEQCKRLKE 1021
L++ + Q K+ KE
Sbjct: 339 QLEEIKLQIKKQKE 352
Score = 42.7 bits (96), Expect = 0.007
Identities = 51/262 (19%), Positives = 114/262 (43%), Gaps = 24/262 (9%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ L++R+L ++ E K +D C E L+E + LK E L+++++
Sbjct: 63 AEIEVLRQRVL----RIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA 118
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
L++ + +++N + + S ++ + K K L + + L
Sbjct: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV-----KVKELESSEDRLD 173
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
+Q L + + K++ + + K K KE E EL + ++ K+++ + A
Sbjct: 174 KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
Query: 1008 YLKQREEQCKRLKEAKIALEIVDKLSNQKVALE--KQIESLSNTPVSNSTMYVATGSAIV 1065
L++ + R+++ I+ + K S +K L+ KQ+E+ + N
Sbjct: 234 NLERND---LRIEDG-ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN--------- 280
Query: 1066 QNQQITDVMKENQKLKKMNAKL 1087
+NQ+ V NQ+++K+ ++
Sbjct: 281 RNQEDNKVKDLNQEIEKLKTQI 302
Score = 41.1 bits (92), Expect = 0.021
Identities = 48/241 (19%), Positives = 107/241 (44%), Gaps = 15/241 (6%)
Query: 862 AEYLQERDEQCARLKKEKL-SLEQQVSNLKEQIRTQQPVERQA-KFADVAVNTD-EDWAN 918
AE+ ++ +R + KL SL +++ L+E + Q E + D + + + +
Sbjct: 2 AEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSM 61
Query: 919 LHSVVVDRMSY------DAEVEKNK---RLMKT-IEELRYKKQDLKNTVTKMQKAMEKYT 968
L + V R D E+++ + RLMK +EE ++LK+ + ++QK M +
Sbjct: 62 LAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE 121
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-E 1027
K ++ F + + L E + K++ E E +K+ E RL + + +L
Sbjct: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT-DVMKENQKLKKMNAK 1086
++KL + ++ + + L+ N + + QN+++ D + L++ + +
Sbjct: 182 ELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLR 241
Query: 1087 L 1087
+
Sbjct: 242 I 242
Score = 38.3 bits (85), Expect = 0.15
Identities = 49/282 (17%), Positives = 115/282 (40%), Gaps = 10/282 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
D E+ + ++ +++L++ + +EL E E + + E ++ + K Q
Sbjct: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEE 945
+L E+ + + + + V V E ++ + S +E+EK K L + + E
Sbjct: 139 LSLNEERNLTKKISSELEMLRVKVKELE--SSEDRLDKTEQSLASELEKLKSLTLSFVSE 196
Query: 946 LRY---KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEE 1001
+Y K+++ + + ++ + +E+ K ++++ LE +E+ + +
Sbjct: 197 RKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESR 256
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
+ +YLKQ E + + E + + ++ N+ L ++IE L ++
Sbjct: 257 RKGGLDYLKQVENETRNKSENE---KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
Query: 1062 SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANREN 1103
+N + D Q K+ A + K + K EN
Sbjct: 314 KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELEN 355
Score = 36.3 bits (80), Expect = 0.61
Identities = 62/258 (24%), Positives = 108/258 (41%), Gaps = 34/258 (13%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN 119
C L S NE +K+S EL ++ + LE L +T L S+++ L
Sbjct: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL---DKTEQSLASELEKL---- 186
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT 179
K+LT S ++ K +NE ++EN+ LI E L ++++ KK N T
Sbjct: 187 -------KSLTLSFVSERKYLNEKEKENE---KLIKE-------LTQKLEQNKKMNRDYT 229
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ +LE+ E+ I + + K L + + N+S ++ N +
Sbjct: 230 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR----NKSENEKNRNQED 285
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
NK+ L E+ E K + F S++ L+ + D L E N+ + A + +
Sbjct: 286 NKVKDLNQEI----EKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ-L 340
Query: 300 SEIKRNLNSLSEQLINNE 317
EIK + ++L N E
Sbjct: 341 EEIKLQIKK-QKELENGE 357
Score = 33.5 bits (73), Expect = 4.3
Identities = 54/276 (19%), Positives = 108/276 (39%), Gaps = 19/276 (6%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDAL--KIAIAKNEEK 570
D LEEA ++ +EL L + +N ++ I++L + + + K K E
Sbjct: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
Query: 571 ML-----SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE--TQ-ASELERSCQV 622
+ L E++N EL S I L++ L+ L + +R K TQ L +
Sbjct: 88 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQCEEKTRDC 679
K+ EL+ ++ + E + L L+ ++ EK ++
Sbjct: 148 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
+L + + + NR R ++ +D L IE + L +K K D +
Sbjct: 208 EKLIKELTQKLEQNKKMNRDYTRNASNLERND-LRIEDGIS-STLPSKESRRKGGLD-YL 264
Query: 740 KDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
K +E+ ++ ++ + ++ +L +I +T
Sbjct: 265 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
>AL031428-1|CAI19705.1| 1026|Homo sapiens leucine zipper protein 1
protein.
Length = 1026
Score = 64.1 bits (149), Expect = 3e-09
Identities = 85/353 (24%), Positives = 151/353 (42%), Gaps = 24/353 (6%)
Query: 66 SSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE 125
SS + KL+ LS L +++E L+ K ++ +L+ Q + + E N + E
Sbjct: 12 SSRHLRFKLQSLSRRLDELEEATKNLQ-KAEDELLDLQDK------VIQAEGSNSSMLAE 64
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I+ L + K E++ D L L+ E + E +NL +E LK E L ++ +L
Sbjct: 65 IEVLRQRVLRIEGKDEEIKRAED-LCRLMKEKLEEEENLTRE---LKSEIERLQKRMAEL 120
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
EKL E+ ++ KN C Q L N ++L + L L + + +S +++
Sbjct: 121 EKL-EEAFSR--SKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE--DRLDKT 175
Query: 246 QSELDAGREDCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ L + E K L F S + +L E + +L +KL +N + + S +
Sbjct: 176 EQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+RN + + + + + SK+ R K L + E T + E + NK + D
Sbjct: 236 ERNDLRIEDGI--SSTLPSKE--SRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK-D 290
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
L++ +EK ELK + K L + ++N +L Q E I
Sbjct: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
Score = 52.8 bits (121), Expect = 7e-06
Identities = 62/263 (23%), Positives = 118/263 (44%), Gaps = 23/263 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
+E E+K E+L +L K K++E NL + L EI+ L+ +A+ E+ + S
Sbjct: 75 IEGKDEEIKRA-EDLCRLMKEKLEEEE---NLTRELKSEIERLQKRMAELEKLEEAFSRS 130
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVI----TREKETQASELERSCQVIKQNGFELDKM 633
N T+L ++N EE N K ++ + + KE ++SE +R + + EL+K+
Sbjct: 131 KNDCTQLCLSLN---EERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQSLASELEKL 186
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN-------I 686
K+ L K L ++ K+ + TR+ S LE N I
Sbjct: 187 KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGI 246
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLE 743
+ + E + + + KQ++ + + E E N+ NK + L ++ + +K E
Sbjct: 247 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
Query: 744 SSREAVNQLTTQ-KDLVEGRIAE 765
S E + ++ ++ DL + ++E
Sbjct: 307 SLEEELKKMKSKNNDLQDNYLSE 329
Score = 47.6 bits (108), Expect = 2e-04
Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 6/194 (3%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS-LEQQVS 887
E+ ++RL +Q L E+ K L + +YL E++++ +L KE LEQ
Sbjct: 164 ELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKK 223
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
++ R +ER + +++ + S + Y +VE R K+ E
Sbjct: 224 MNRDYTRNASNLERNDLRIEDGISST--LPSKESRRKGGLDYLKQVENETR-NKSENEKN 280
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
++D N V + + +EK + K FE+ +EL+ K++ +L+ Y + + A
Sbjct: 281 RNQED--NKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Query: 1008 YLKQREEQCKRLKE 1021
L++ + Q K+ KE
Sbjct: 339 QLEEIKLQIKKQKE 352
Score = 42.7 bits (96), Expect = 0.007
Identities = 51/262 (19%), Positives = 114/262 (43%), Gaps = 24/262 (9%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ L++R+L ++ E K +D C E L+E + LK E L+++++
Sbjct: 63 AEIEVLRQRVL----RIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA 118
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
L++ + +++N + + S ++ + K K L + + L
Sbjct: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV-----KVKELESSEDRLD 173
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
+Q L + + K++ + + K K KE E EL + ++ K+++ + A
Sbjct: 174 KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
Query: 1008 YLKQREEQCKRLKEAKIALEIVDKLSNQKVALE--KQIESLSNTPVSNSTMYVATGSAIV 1065
L++ + R+++ I+ + K S +K L+ KQ+E+ + N
Sbjct: 234 NLERND---LRIEDG-ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN--------- 280
Query: 1066 QNQQITDVMKENQKLKKMNAKL 1087
+NQ+ V NQ+++K+ ++
Sbjct: 281 RNQEDNKVKDLNQEIEKLKTQI 302
Score = 41.1 bits (92), Expect = 0.021
Identities = 48/241 (19%), Positives = 107/241 (44%), Gaps = 15/241 (6%)
Query: 862 AEYLQERDEQCARLKKEKL-SLEQQVSNLKEQIRTQQPVERQA-KFADVAVNTD-EDWAN 918
AE+ ++ +R + KL SL +++ L+E + Q E + D + + + +
Sbjct: 2 AEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSM 61
Query: 919 LHSVVVDRMSY------DAEVEKNK---RLMKT-IEELRYKKQDLKNTVTKMQKAMEKYT 968
L + V R D E+++ + RLMK +EE ++LK+ + ++QK M +
Sbjct: 62 LAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE 121
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-E 1027
K ++ F + + L E + K++ E E +K+ E RL + + +L
Sbjct: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
Query: 1028 IVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQIT-DVMKENQKLKKMNAK 1086
++KL + ++ + + L+ N + + QN+++ D + L++ + +
Sbjct: 182 ELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLR 241
Query: 1087 L 1087
+
Sbjct: 242 I 242
Score = 38.3 bits (85), Expect = 0.15
Identities = 49/282 (17%), Positives = 115/282 (40%), Gaps = 10/282 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
D E+ + ++ +++L++ + +EL E E + + E ++ + K Q
Sbjct: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEE 945
+L E+ + + + + V V E ++ + S +E+EK K L + + E
Sbjct: 139 LSLNEERNLTKKISSELEMLRVKVKELE--SSEDRLDKTEQSLASELEKLKSLTLSFVSE 196
Query: 946 LRY---KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEE 1001
+Y K+++ + + ++ + +E+ K ++++ LE +E+ + +
Sbjct: 197 RKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESR 256
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
+ +YLKQ E + + E + + ++ N+ L ++IE L ++
Sbjct: 257 RKGGLDYLKQVENETRNKSENE---KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
Query: 1062 SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANREN 1103
+N + D Q K+ A + K + K EN
Sbjct: 314 KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELEN 355
Score = 36.3 bits (80), Expect = 0.61
Identities = 62/258 (24%), Positives = 108/258 (41%), Gaps = 34/258 (13%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN 119
C L S NE +K+S EL ++ + LE L +T L S+++ L
Sbjct: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL---DKTEQSLASELEKL---- 186
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT 179
K+LT S ++ K +NE ++EN+ LI E L ++++ KK N T
Sbjct: 187 -------KSLTLSFVSERKYLNEKEKENE---KLIKE-------LTQKLEQNKKMNRDYT 229
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ +LE+ E+ I + + K L + + N+S ++ N +
Sbjct: 230 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR----NKSENEKNRNQED 285
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
NK+ L E+ E K + F S++ L+ + D L E N+ + A + +
Sbjct: 286 NKVKDLNQEI----EKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ-L 340
Query: 300 SEIKRNLNSLSEQLINNE 317
EIK + ++L N E
Sbjct: 341 EEIKLQIKK-QKELENGE 357
Score = 33.5 bits (73), Expect = 4.3
Identities = 54/276 (19%), Positives = 108/276 (39%), Gaps = 19/276 (6%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDAL--KIAIAKNEEK 570
D LEEA ++ +EL L + +N ++ I++L + + + K K E
Sbjct: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
Query: 571 ML-----SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE--TQ-ASELERSCQV 622
+ L E++N EL S I L++ L+ L + +R K TQ L +
Sbjct: 88 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQCEEKTRDC 679
K+ EL+ ++ + E + L L+ ++ EK ++
Sbjct: 148 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
+L + + + NR R ++ +D L IE + L +K K D +
Sbjct: 208 EKLIKELTQKLEQNKKMNRDYTRNASNLERND-LRIEDGIS-STLPSKESRRKGGLD-YL 264
Query: 740 KDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
K +E+ ++ ++ + ++ +L +I +T
Sbjct: 265 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
>AK074153-1|BAB84979.1| 1046|Homo sapiens FLJ00226 protein protein.
Length = 1046
Score = 64.1 bits (149), Expect = 3e-09
Identities = 85/353 (24%), Positives = 151/353 (42%), Gaps = 24/353 (6%)
Query: 66 SSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKE 125
SS + KL+ LS L +++E L+ K ++ +L+ Q + + E N + E
Sbjct: 5 SSRHLRFKLQSLSPRLDELEEATKNLQ-KAEDELLDLQDK------VIQAEGSNSSMLAE 57
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I+ L + K E++ D L L+ E + E +NL +E LK E L ++ +L
Sbjct: 58 IEVLRQRVLRIEGKDEEIKRAED-LCRLMKEKLEEEENLTRE---LKSEIERLQKRMAEL 113
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
EKL E+ ++ KN C Q L N ++L + L L + + +S +++
Sbjct: 114 EKL-EEAFSR--SKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE--DRLDKT 168
Query: 246 QSELDAGREDCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ L + E K L F S + +L E + +L +KL +N + + S +
Sbjct: 169 EQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 228
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID 362
+RN + + + + + SK+ R K L + E T + E + NK + D
Sbjct: 229 ERNDLRIEDGI--SSTLPSKE--SRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK-D 283
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
L++ +EK ELK + K L + ++N +L Q E I
Sbjct: 284 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 336
Score = 52.8 bits (121), Expect = 7e-06
Identities = 62/263 (23%), Positives = 118/263 (44%), Gaps = 23/263 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
+E E+K E+L +L K K++E NL + L EI+ L+ +A+ E+ + S
Sbjct: 68 IEGKDEEIKRA-EDLCRLMKEKLEEEE---NLTRELKSEIERLQKRMAELEKLEEAFSRS 123
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVI----TREKETQASELERSCQVIKQNGFELDKM 633
N T+L ++N EE N K ++ + + KE ++SE +R + + EL+K+
Sbjct: 124 KNDCTQLCLSLN---EERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQSLASELEKL 179
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN-------I 686
K+ L K L ++ K+ + TR+ S LE N I
Sbjct: 180 KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGI 239
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDLE 743
+ + E + + + KQ++ + + E E N+ NK + L ++ + +K E
Sbjct: 240 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 299
Query: 744 SSREAVNQLTTQ-KDLVEGRIAE 765
S E + ++ ++ DL + ++E
Sbjct: 300 SLEEELKKMKSKNNDLQDNYLSE 322
Score = 47.6 bits (108), Expect = 2e-04
Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 6/194 (3%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLS-LEQQVS 887
E+ ++RL +Q L E+ K L + +YL E++++ +L KE LEQ
Sbjct: 157 ELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKK 216
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
++ R +ER + +++ + S + Y +VE R K+ E
Sbjct: 217 MNRDYTRNASNLERNDLRIEDGISST--LPSKESRRKGGLDYLKQVENETR-NKSENEKN 273
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
++D N V + + +EK + K FE+ +EL+ K++ +L+ Y + + A
Sbjct: 274 RNQED--NKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 331
Query: 1008 YLKQREEQCKRLKE 1021
L++ + Q K+ KE
Sbjct: 332 QLEEIKLQIKKQKE 345
Score = 42.7 bits (96), Expect = 0.007
Identities = 51/262 (19%), Positives = 114/262 (43%), Gaps = 24/262 (9%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ L++R+L ++ E K +D C E L+E + LK E L+++++
Sbjct: 56 AEIEVLRQRVL----RIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA 111
Query: 888 NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELR 947
L++ + +++N + + S ++ + K K L + + L
Sbjct: 112 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV-----KVKELESSEDRLD 166
Query: 948 YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAE 1007
+Q L + + K++ + + K K KE E EL + ++ K+++ + A
Sbjct: 167 KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 226
Query: 1008 YLKQREEQCKRLKEAKIALEIVDKLSNQKVALE--KQIESLSNTPVSNSTMYVATGSAIV 1065
L++ + R+++ I+ + K S +K L+ KQ+E+ + N
Sbjct: 227 NLERND---LRIEDG-ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN--------- 273
Query: 1066 QNQQITDVMKENQKLKKMNAKL 1087
+NQ+ V NQ+++K+ ++
Sbjct: 274 RNQEDNKVKDLNQEIEKLKTQI 295
Score = 42.3 bits (95), Expect = 0.009
Identities = 39/181 (21%), Positives = 87/181 (48%), Gaps = 5/181 (2%)
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
AE+E ++ + IE + + ++ M++ +E+ +E +++ + L+ AELE+
Sbjct: 56 AEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK 115
Query: 991 LKQRYKELDEEC-ETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
L++ + +C + C ++R K E ++ V +L + + L+K +SL++
Sbjct: 116 LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASE 175
Query: 1050 PVSNSTMYVATGSAIVQNQQITDVMKENQKL-KKMNAKLITICKKRGKTGANRENEDPSD 1108
++ T S + + + + + KEN+KL K++ KL K N N + +D
Sbjct: 176 LEKLKSL---TLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERND 232
Query: 1109 V 1109
+
Sbjct: 233 L 233
Score = 39.5 bits (88), Expect = 0.065
Identities = 51/256 (19%), Positives = 101/256 (39%), Gaps = 12/256 (4%)
Query: 856 DECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDED 915
DE E + LQ+ +++ L+ + + E S++ +I + + + D + ED
Sbjct: 21 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 80
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L + + E + L IE L+ + +L+ ++ T+
Sbjct: 81 LCRLM-----KEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 135
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQ 1035
+R + +ELE L+ + KEL+ + + + + ++LK ++ K N+
Sbjct: 136 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 195
Query: 1036 K-VALEKQIESLSNTPVSNSTM---YVATGSAIVQNQ-QITDVMKENQKLKKMNAK--LI 1088
K EK I+ L+ N M Y S + +N +I D + K+ K L
Sbjct: 196 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLD 255
Query: 1089 TICKKRGKTGANRENE 1104
+ + +T ENE
Sbjct: 256 YLKQVENETRNKSENE 271
Score = 38.3 bits (85), Expect = 0.15
Identities = 49/282 (17%), Positives = 115/282 (40%), Gaps = 10/282 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
D E+ + ++ +++L++ + +EL E E + + E ++ + K Q
Sbjct: 72 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 131
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEE 945
+L E+ + + + + V V E ++ + S +E+EK K L + + E
Sbjct: 132 LSLNEERNLTKKISSELEMLRVKVKELE--SSEDRLDKTEQSLASELEKLKSLTLSFVSE 189
Query: 946 LRY---KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE-LKQRYKELDEE 1001
+Y K+++ + + ++ + +E+ K ++++ LE +E+ + +
Sbjct: 190 RKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESR 249
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
+ +YLKQ E + + E + + ++ N+ L ++IE L ++
Sbjct: 250 RKGGLDYLKQVENETRNKSENE---KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 306
Query: 1062 SAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANREN 1103
+N + D Q K+ A + K + K EN
Sbjct: 307 KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELEN 348
Score = 36.3 bits (80), Expect = 0.61
Identities = 62/258 (24%), Positives = 108/258 (41%), Gaps = 34/258 (13%)
Query: 60 CQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMEN 119
C L S NE +K+S EL ++ + LE L +T L S+++ L
Sbjct: 127 CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL---DKTEQSLASELEKL---- 179
Query: 120 LTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLT 179
K+LT S ++ K +NE ++EN+ LI E L ++++ KK N T
Sbjct: 180 -------KSLTLSFVSERKYLNEKEKENE---KLIKE-------LTQKLEQNKKMNRDYT 222
Query: 180 QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRY 239
+ +LE+ E+ I + + K L + + N+S ++ N +
Sbjct: 223 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR----NKSENEKNRNQED 278
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
NK+ L E+ E K + F S++ L+ + D L E N+ + A + +
Sbjct: 279 NKVKDLNQEI----EKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ-L 333
Query: 300 SEIKRNLNSLSEQLINNE 317
EIK + ++L N E
Sbjct: 334 EEIKLQIKK-QKELENGE 350
Score = 33.5 bits (73), Expect = 4.3
Identities = 54/276 (19%), Positives = 108/276 (39%), Gaps = 19/276 (6%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDAL--KIAIAKNEEK 570
D LEEA ++ +EL L + +N ++ I++L + + + K K E
Sbjct: 21 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 80
Query: 571 ML-----SLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKE--TQ-ASELERSCQV 622
+ L E++N EL S I L++ L+ L + +R K TQ L +
Sbjct: 81 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 140
Query: 623 IKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQCEEKTRDC 679
K+ EL+ ++ + E + L L+ ++ EK ++
Sbjct: 141 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 200
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
+L + + + NR R ++ +D L IE + L +K K D +
Sbjct: 201 EKLIKELTQKLEQNKKMNRDYTRNASNLERND-LRIEDGIS-STLPSKESRRKGGLD-YL 257
Query: 740 KDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
K +E+ ++ ++ + ++ +L +I +T
Sbjct: 258 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 293
>U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase p160ROCK protein.
Length = 1354
Score = 63.7 bits (148), Expect = 4e-09
Identities = 125/723 (17%), Positives = 300/723 (41%), Gaps = 82/723 (11%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ES + KLE+ +L + + K +E K + ++ D +M ++ +
Sbjct: 422 KSLQESLQKTIYKLEE---QLHNEMQLKDEMEQKCRTSNIKL---DKIMKELDEEGNQRR 475
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKK---NNEC 177
+ + + +INE Q + + + E L +++DLKK N++
Sbjct: 476 NLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL 535
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTST 237
+K L+K + E+ + + ++ A K + S I + L LNR + + N
Sbjct: 536 ANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSI---SQLESLNRELQERNRIL 592
Query: 238 RYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK 297
+K S+ D +D+ ++ LE + D E +G+ T +
Sbjct: 593 ENSK-----SQTD----------KDYYQLQAILEAERRDRGHD-SEMIGDLQARITSLQE 636
Query: 298 VMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIIN 357
+ +K NL + + E++ +H ++ K++L +D + SL + ++ +N
Sbjct: 637 EVKHLKHNLEKVEGE--RKEAQDMLNHSEKEKNNL--EIDLNYKLKSL---QQRLEQEVN 689
Query: 358 KYQIDLDEILEKYTKVQGDLN----ECTSELKSVNEKLASLNSQLIEKENACNILRI--- 410
++++ + +K+ ++ + E +LK E +++++ E C++L +
Sbjct: 690 EHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLK 749
Query: 411 -----------QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDL 459
KER+ + +T+ + ++ N K +L + LK + D + L++ +
Sbjct: 750 QSQQKLEHLTGNKERMEDEVKNLTLQLEQESN--KRLLLQNELKTQAFEADNLKGLEKQM 807
Query: 460 PAHKKITILFDA-LITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
++I L +A + ++EL++ ++ R G + + +
Sbjct: 808 --KQEINTLLEAKRLLEFELAQL-----TKQYRGNEGQMRELQDQLEAEQYFSTLYKTQV 860
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
+E E++ + E K + +E + + + ++ ++A EE+ L+++
Sbjct: 861 KELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQES 920
Query: 579 NK--------LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK-QNGFE 629
K +T+ T++ L+E N+ L +++ RE E +++++ + K + E
Sbjct: 921 KKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEE 980
Query: 630 LDKMKA----DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEIN 685
+ +KA +I + +++ A + +K ++ +L++
Sbjct: 981 ISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLE 1040
Query: 686 IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYD---AAVKDL 742
+ + E N+M+++ QK++ + +E+ NEL + + + D + A + DL
Sbjct: 1041 L---NQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDL 1097
Query: 743 ESS 745
S
Sbjct: 1098 SDS 1100
Score = 56.8 bits (131), Expect = 4e-07
Identities = 125/639 (19%), Positives = 261/639 (40%), Gaps = 57/639 (8%)
Query: 32 SKNDNIIETQSNPIK-LQDSGTITI---------SCKMCQSLKESSNEINLKLEKLSGEL 81
S N N T SN K LQ+S TI ++ +++ N+KL+K+ EL
Sbjct: 408 SANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKEL 467
Query: 82 FDIKEQKSALEGKYQNLILETQTRDLLMSQI-KSLEMENLTK---DKEIKNLTDSLKTKS 137
+ Q+ LE + E +++ + E EN + + E+ L D L+
Sbjct: 468 DEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK 527
Query: 138 KKINELQEENDTLSNLIMENVTESDNLNKEVDD---LKKNNECLTQKCIDLEKLVNE--S 192
K Q N+ LS L + +D L E D L+K++ +++ LE L E
Sbjct: 528 KVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQE 587
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
N+I +N +Q +Q++ + I D +I +LQ E+
Sbjct: 588 RNRI-LENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQA-----RITSLQEEVKHL 641
Query: 253 REDCKEL---CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSL 309
+ + +++ ++ + NH E + N+ +DL+ KL + + V K L
Sbjct: 642 KHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDK 701
Query: 310 SEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + +S + + K+ A AE ++ ++D + + Q L+ +
Sbjct: 702 HQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGN 761
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQL-IEKENACNILRIQKERIHEISSAVTIDIVK 428
+++ ++ T +L+ + K L ++L + A N+ ++K+ EI++ +
Sbjct: 762 KERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLL------ 815
Query: 429 KENELKEILTKECLKLSKL---KIDIPRDLDQDLPAHKKITILFDALITQY--ELSRTDY 483
E K +L E +L+K R+L L A + + L+ + + E+ +
Sbjct: 816 ---EAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNR 872
Query: 484 EIEK--EKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD 541
E K ++L+ E T LEE + E+ ++ + ++
Sbjct: 873 ENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEIT 932
Query: 542 ENNANLNLIK----ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNS 597
+ + ++ ++ +L+++I+ L+ +NEE L+EK K E + +E +N
Sbjct: 933 DKDHTVSRLEEANSMLTKDIEILR---RENEE----LTEKMKKAEEEYK-LEKEEEISNL 984
Query: 598 LKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+ I E+ + + + +++ + F++D+ KA+
Sbjct: 985 KAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKAN 1023
Score = 54.8 bits (126), Expect = 2e-06
Identities = 116/623 (18%), Positives = 257/623 (41%), Gaps = 51/623 (8%)
Query: 523 NEVKSLHEELTK-LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL 581
N KSL E L K +YK + +N +++ E + + K ++ M L E+ N+
Sbjct: 419 NADKSLQESLQKTIYKLEEQLHNE----MQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR 474
Query: 582 TELVSTINGLKEENNSLKSLNDVITREKETQASE---LERSCQVIKQNGFELDKMKADIL 638
L ST++ +++E L+ + R+ E + + +E +K +L K+ +
Sbjct: 475 RNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQ 534
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE-INIKTHEKTAEIQN 697
+ D ++ + + L++ E ++ S+LE +N + E+ ++N
Sbjct: 535 LANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILEN 594
Query: 698 ------------RMIMRLQKQIQ-EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLES 744
+ I+ +++ + D ++ + + ++ L + + LK + + + +
Sbjct: 595 SKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKE 654
Query: 745 SREAVNQLTTQKDLVEGRIA-ELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
+++ +N +K+ +E + +L+S R EQ
Sbjct: 655 AQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMC 714
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
+ + L E + + + + I + + S L L QQ+L+ L + ++DE +
Sbjct: 715 EMEKKLKEEREAREKAENRVVQI-EKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT 773
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNL-------KEQIRTQQPVERQAKFADVAVNTDED 915
L++ + L+ E + + NL K++I T +R +F ++A T +
Sbjct: 774 LQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEF-ELAQLTKQY 832
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
N + + +AE + ++EL+ + ++ KN ++K E + +KE
Sbjct: 833 RGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEE-KNR-ENLKKIQE--LQNEKETL 888
Query: 976 AKRKELEDCKAELEE-----LKQRYKELDEECETCAEYLKQ----REEQCKRLKEAKIAL 1026
A + +L + KAE E+ L+++Y EL +E + A +Q ++ RL+EA L
Sbjct: 889 ATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSML 948
Query: 1027 -EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKK--- 1082
+ ++ L + L ++++ ++ A + T+ + Q + K
Sbjct: 949 TKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAE 1008
Query: 1083 -MNAKLITICKKRGKTGANRENE 1104
MN K I +K+ T R+ E
Sbjct: 1009 IMNRKDFKIDRKKANTQDLRKKE 1031
>AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting citron
kinase protein.
Length = 2027
Score = 63.7 bits (148), Expect = 4e-09
Identities = 130/688 (18%), Positives = 265/688 (38%), Gaps = 31/688 (4%)
Query: 382 SELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKEC 441
++ S+ +KL + +L + ++ C+ + + R+H S V + +KE ELK T+
Sbjct: 442 AKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRS 501
Query: 442 LKLSKLKI------DIPRDLDQ-DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLET 494
L L + R L+Q + ++ L E SR EI++++ + +
Sbjct: 502 LLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQV 561
Query: 495 GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILS 554
+ + D E E + EE +K K E L K
Sbjct: 562 EEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE----FKRKATECQHKLLKAKDQG 617
Query: 555 E-EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQA 613
+ E+ N E+ L + E KL + V E +++ + RE E +
Sbjct: 618 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELE-KL 676
Query: 614 SELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCE 673
E S + I++ E ++++ + + E+ L Q +
Sbjct: 677 QNREDSSEGIRKKLVEAEELEE---KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK 733
Query: 674 EKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKR 733
+ D LE ++ HE+ A + +++ + I D E ++ EL+ +
Sbjct: 734 KDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN 793
Query: 734 DYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR--TEQTATVXXXXXXXXXXXXX 791
+++++ E +++L QK +E + +LE+ R EQ +
Sbjct: 794 SSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLE 853
Query: 792 XXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQ--QELDDLKE 849
+ E + L +L + S Q L Q Q +L+E
Sbjct: 854 LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 913
Query: 850 RYKELDDECETCAEYLQERDEQCARLKKE---KLSLEQQVSNLKE-QIRTQQPVERQAKF 905
E ++E + + E + L+ LE+Q++ L E +K
Sbjct: 914 TTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 973
Query: 906 ADVAVNTDEDWANLHSVV--VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKA 963
D A +++ L S V + R + E++ + +T+E L+ L+ V ++
Sbjct: 974 LDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ-KQTMEALKTTCTMLEEQVMDLEAL 1032
Query: 964 MEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQREEQCKRLKEA 1022
++ +K++++EA R L D K++ E +++ + LD E ++ A QR + +++ E
Sbjct: 1033 NDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRAR-ADQRITESRQVVEL 1091
Query: 1023 KIALEIVDKLSNQKVALEKQI--ESLSN 1048
+ + L+ Q+ E+++ ESLS+
Sbjct: 1092 AVKEHKAEILALQQALKEQKLKAESLSD 1119
Score = 61.7 bits (143), Expect = 1e-08
Identities = 141/723 (19%), Positives = 297/723 (41%), Gaps = 68/723 (9%)
Query: 39 ETQSNPIKLQDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSAL-EGKYQ 96
ETQ + ++ QD T C + +SL+++ E++ + +K L DI+EQ L E K Q
Sbjct: 497 ETQRSLLE-QDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ 555
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDS-LKTKSKKINELQEENDTLSNLIM 155
+ + L+M+Q++ E+L + +L +S L+ E + + + ++
Sbjct: 556 EYQAQVEEMRLMMNQLE----EDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLL 611
Query: 156 ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSL 215
+ D EV + K + ++ + +++L + E K + A + E L+Q++
Sbjct: 612 K---AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLE-----KAVKASTEATE-LLQNI 662
Query: 216 HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEP 275
+ +L + + ++S K EL+ + + + HLE+H
Sbjct: 663 RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQ-------HLEVHLK 715
Query: 276 NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAV 335
+EK+ + + K +++ K L ++ ++ + E K I + +++
Sbjct: 716 QKEQHYEEKI---KVLDNQIKKDLAD-KETLENMMQR--HEEEAHEKGKILSEQKAMINA 769
Query: 336 LDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLN 395
+D++ + + E+ + NK + ++ K Q E SEL+ L +
Sbjct: 770 MDSKIRSLEQRIVEL---SEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQA 823
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+L E +N L Q E+I + +++ E L+E+ L+ + K+++ R L
Sbjct: 824 GKL-EAQN--RKLEEQLEKISHQDHSDKNRLLELETRLREV----SLEHEEQKLELKRQL 876
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX- 514
+ + ++ AL Q + + ++ + K LE TA+A
Sbjct: 877 TELQLSLQERESQLTAL--QAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR 934
Query: 515 -FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
FD L + + L E+L +L + + NN N L K L E A N+E +
Sbjct: 935 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDE-------ASGANDEIVQL 987
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE D+ E+ L + ++++L T +E Q +LE + + + +
Sbjct: 988 RSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE-QVMDLEALNDELLEKERQWEAW 1046
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
++ + E + +L+ + + +++ + SR + + E A
Sbjct: 1047 RSVL-------GDEKSQFECRVRELQRMLDTEKQSRARADQRITE-SRQVVELAVKEHKA 1098
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
E I+ LQ+ ++E KLN+L K+ L+ + + + LE+ RE +L
Sbjct: 1099 E-----ILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLL 1153
Query: 754 TQK 756
++
Sbjct: 1154 EEQ 1156
Score = 49.6 bits (113), Expect = 6e-05
Identities = 110/545 (20%), Positives = 207/545 (37%), Gaps = 46/545 (8%)
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDALKIAIAKN-EEKMLSLS 575
EA N + L E+L K+ + N L L ++ +S E + K+ + + E LSL
Sbjct: 827 EAQN--RKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 884
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
E++++LT L + L+ + K+ E E +E E Q + + E+ +
Sbjct: 885 ERESQLTALQAARAALESQLRQAKT-------ELEETTAEAEEEIQALTAHRDEIQRKFD 937
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINIKTHEKTAE 694
+ ++ L QN L +Q +E + + ++ + E
Sbjct: 938 ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 997
Query: 695 IQNR-MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
I R M + QKQ E K T L E EAL + + E+ R +
Sbjct: 998 ITEREMQLTSQKQTMEALKTTC---TMLEEQVMDLEALNDELLEKERQWEAWRSVLGD-- 1052
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
+K E R+ EL+ + TE+ + E+R + E
Sbjct: 1053 -EKSQFECRVRELQRMLDTEKQSRARADQRIT------------------ESRQVVELAV 1093
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
+ K I + + + + K + S +L+DL++++ L+ + + L+ E
Sbjct: 1094 KEH--KAEILALQQA-LKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ 1150
Query: 874 RLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
RL +E+ L+QQ+ K I R Q ++ AD+ D + + ++ Y E
Sbjct: 1151 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE--YQLENIQVLYSHE 1208
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDCKAELEEL 991
K + + +L Q + K +K + K+D + + + K LE+
Sbjct: 1209 KVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKE 1268
Query: 992 KQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPV 1051
K R EL+E + L+ E+ K + Q++A+ + S + P
Sbjct: 1269 KARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPS 1328
Query: 1052 SNSTM 1056
+ S +
Sbjct: 1329 AMSLL 1333
Score = 49.2 bits (112), Expect = 8e-05
Identities = 61/273 (22%), Positives = 116/273 (42%), Gaps = 16/273 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKER-YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
D + QL + ++L ++KE+ Y+ +E L+E D AR + + E +
Sbjct: 532 DDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEE-DLVSARRRSDLYESELR 590
Query: 886 VSNLKEQIRTQQPVERQAKFA---DVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMK 941
S L + ++ E Q K D ++A L + ++ E+ EK ++ +K
Sbjct: 591 ESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVK 650
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
E Q+++ + ++ +EK ++ E RK+L E EEL+++++E
Sbjct: 651 ASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL----VEAEELEEKHREAQVS 706
Query: 1002 CETCAEYLKQRE---EQCKRLKEAKIALEIVDK--LSNQKVALEKQIESLSNTPVSNSTM 1056
+ +LKQ+E E+ ++ + +I ++ DK L N E++ M
Sbjct: 707 AQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAM 766
Query: 1057 YVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
A S I +Q + E KL N+ L T
Sbjct: 767 INAMDSKIRSLEQRIVELSEANKL-AANSSLFT 798
Score = 44.8 bits (101), Expect = 0.002
Identities = 64/298 (21%), Positives = 130/298 (43%), Gaps = 24/298 (8%)
Query: 56 SCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL 115
SC + L+E N++ +L+ + F + +Q G ++ D L +I
Sbjct: 942 SCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER 1001
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
EM+ LT K+ ++LKT + E + + L++ ++E + + + D K
Sbjct: 1002 EMQ-LTSQKQ---TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF 1057
Query: 176 ECLT---QKCIDLEKLVN-ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLN-RSI 230
EC Q+ +D EK ++ +I + +KE+ + L + KL S+
Sbjct: 1058 ECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL 1117
Query: 231 SDS-NTSTRYNKIC-----TLQSELDAGREDCKELCEDFTSIKNHLEL---HEPNMTMDL 281
SD N + + + +LQ +L+ RE + L E+ ++ ++L H +T L
Sbjct: 1118 SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 1177
Query: 282 DEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAE 339
E L + +T+ S+++ L ++ + L ++E K + I + + L+ L A+
Sbjct: 1178 QEALDRADLLKTE----RSDLEYQLENI-QVLYSHEKVKMEGTISQ-QTKLIDFLQAK 1229
>BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein.
Length = 498
Score = 63.3 bits (147), Expect = 5e-09
Identities = 95/459 (20%), Positives = 182/459 (39%), Gaps = 29/459 (6%)
Query: 607 REKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
REKET+A L R+ + + EL++ M L +
Sbjct: 5 REKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDDVGKNVHELEKSKR 61
Query: 667 ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
AL+ Q EE LE ++ E A+++ + M+ K E D ++ + NE
Sbjct: 62 ALETQMEEMKTQLEELEDELQATED-AKLRLEVNMQALKGQFERD---LQARDEQNE--E 115
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXX 786
K L+R +LE R+ K +EG + +LE +
Sbjct: 116 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKG 165
Query: 787 XXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDD 846
D R+L E+ + + + ++ + L+ L+ Q++L
Sbjct: 166 REEAIKQLRKLQAQMKDFQREL-EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 224
Query: 847 LKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP-----VER 901
+ K+ D E E AE L L+ EK LE +++ L+E++ +Q +R
Sbjct: 225 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 284
Query: 902 QAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYK-KQDLKNTVTK 959
K A + A S S ++E+ NK L + E+ K K+T+
Sbjct: 285 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 344
Query: 960 MQKAMEKYTKK-DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
++ + + ++ ++E K+ + K + ++LK+ ++++E + +Y +Q E+ R
Sbjct: 345 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 404
Query: 1019 LKEAKIALEIVDKLSNQKVALEKQIE-SLSNTPVSNSTM 1056
+K+ K LE ++ S + A ++++ L SN M
Sbjct: 405 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 443
Score = 48.4 bits (110), Expect = 1e-04
Identities = 96/469 (20%), Positives = 184/469 (39%), Gaps = 36/469 (7%)
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
EK+ K L + E L+ N ++ E E +L S + +N EL+K K
Sbjct: 6 EKETKALSLARALEEALEAKEELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSKR 61
Query: 636 DI---LMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDCSRLEINIKTHEK 691
+ + ++AK LE N+ ALK Q E + +R E N EK
Sbjct: 62 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ--ARDEQN---EEK 116
Query: 692 TAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ 751
++Q R + + +++++ K +L + L+ D+A+K E + + + +
Sbjct: 117 RRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 175
Query: 752 LTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGEN 811
L Q + + + + R E AT + R +
Sbjct: 176 LQAQMKDFQRELEDARAS-RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 234
Query: 812 PKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQ 871
K + + + + S+ + + K RL + + L+E +E E ++ +++ +Q
Sbjct: 235 EKEELAEELASSLSGRNALQDEKRRL---EARIAQLEEELEEEQGNMEAMSDRVRKATQQ 291
Query: 872 CARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV-VDRMSYD 930
+L E L+ E+ + E R Q +ERQ K E + LH + + +
Sbjct: 292 AEQLSNE-LATERSTAQKNESARQQ--LERQNK---------ELRSKLHEMEGAVKSKFK 339
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK-EFEAKRKELEDCKAELE 989
+ + + + +EE ++ K TK K +K K+ + E +RK E K + E
Sbjct: 340 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 399
Query: 990 E----LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSN 1034
+ +KQ ++L+E E R + + L EA + E + + N
Sbjct: 400 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 448
Score = 45.6 bits (103), Expect = 0.001
Identities = 82/391 (20%), Positives = 164/391 (41%), Gaps = 31/391 (7%)
Query: 732 KRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXX 791
K D V +LE S+ A L TQ + ++ ++ ELE +++ + A +
Sbjct: 46 KDDVGKNVHELEKSKRA---LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 102
Query: 792 XXXXXXXXTFGDENR-----DLGE-NPKLDDSPK-RSISVISDSEVS-QLKERLLSCQQE 843
+E R L E +L+D K R+++ + ++ LK+ L
Sbjct: 103 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 162
Query: 844 LDDLKERYKELDDECETCAEYLQE-------RDEQCARLK---KEKLSLEQQVSNLKEQI 893
+ +E K+L ++ +E RDE A K K+ SLE + L+E +
Sbjct: 163 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 222
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK-NKRLMKTIEELRYKKQD 952
ER K AD+ +E L S + R + E + R+ + EEL ++ +
Sbjct: 223 AA---AERARKQADL--EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 277
Query: 953 LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQR 1012
++ +++KA ++ + E +R + ++ ++L+++ KEL + +K +
Sbjct: 278 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 337
Query: 1013 EEQCKRLKEAKIAL--EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQI 1070
+ EAKIA E V++ + +K A K ++ + + + V + + Q
Sbjct: 338 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-KDKKLKEILLQVEDERKMAE-QYK 395
Query: 1071 TDVMKENQKLKKMNAKLITICKKRGKTGANR 1101
K N ++K++ +L ++ + ANR
Sbjct: 396 EQAEKGNARVKQLKRQLEEAEEESQRINANR 426
Score = 43.6 bits (98), Expect = 0.004
Identities = 79/445 (17%), Positives = 171/445 (38%), Gaps = 22/445 (4%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS-LSE 576
LEEA E K E K+ K+++++ ++ + + E++ K A+ E+M + L E
Sbjct: 18 LEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 76
Query: 577 KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKAD 636
+++L L+ +LK + + ++ Q E R Q +L + + +
Sbjct: 77 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEYETE 130
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSL-LEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ + K L L+ + A+K + EE + +L+ +K ++ E
Sbjct: 131 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELED 189
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKR-------DYDAAVKDLESSREA 748
+ +E++K E L +L A +R + + ++L SS
Sbjct: 190 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 249
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQ---TATVXXXXXXXXXXXXXXXXXXXXXTFGDEN 805
N L +K +E RIA+LE ++ EQ A + +N
Sbjct: 250 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 309
Query: 806 RDLGENPKLDDSPKRS-ISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEY 864
+ + + RS + + + S+ K + + + ++ L+E+ ++ E + +
Sbjct: 310 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 369
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVV 924
L+++D++ + + + KEQ +Q K + N + +
Sbjct: 370 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 429
Query: 925 DRMSYDAEVEKNKRLMKTIEELRYK 949
R D E N+ + + + L+ K
Sbjct: 430 QR-ELDEATESNEAMGREVNALKSK 453
Score = 36.3 bits (80), Expect = 0.61
Identities = 37/159 (23%), Positives = 74/159 (46%), Gaps = 11/159 (6%)
Query: 932 EVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL-------ED 983
E+E+ +++K +E+L K D+ V +++K+ + +E + + +EL ED
Sbjct: 27 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 86
Query: 984 CKAELEELKQRYK-ELDEECETCAEYLKQREEQCKR-LKEAKIALEIVDKLSNQKVALEK 1041
K LE Q K + + + + E +++ Q +R L E + LE K A +K
Sbjct: 87 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 146
Query: 1042 QIE-SLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQK 1079
++E L + + + AI Q +++ MK+ Q+
Sbjct: 147 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 185
Score = 32.3 bits (70), Expect = 9.9
Identities = 32/154 (20%), Positives = 70/154 (45%), Gaps = 9/154 (5%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMC--QSLKESSNEINLKLEKLSGELFD 83
QL+ + +E S+ ++ +S ++ +S + + +LE+ + EL
Sbjct: 266 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 325
Query: 84 -IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E + A++ K+++ I L ++I LE + + +E + T SLK K KK+ E
Sbjct: 326 KLHEMEGAVKSKFKSTIAA------LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 379
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
+ + + + + +++ N V LK+ E
Sbjct: 380 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 413
>BC050555-1|AAH50555.1| 873|Homo sapiens KTN1 protein protein.
Length = 873
Score = 63.3 bits (147), Expect = 5e-09
Identities = 115/575 (20%), Positives = 247/575 (42%), Gaps = 44/575 (7%)
Query: 526 KSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-LTEL 584
KS ELT L +++ L+ + E+ A K + ++M++ E+ N +T +
Sbjct: 321 KSSKGELTTLIHQLQEKDK----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM 376
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI-LMXXXX 643
I L++E+N + N + +ETQ +++ QV +Q E+ +K + ++
Sbjct: 377 KDRIGTLEKEHNVFQ--NKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAV 433
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRL 703
E L + L + EKT + E+ K E+ A +L
Sbjct: 434 SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT-------QL 486
Query: 704 QKQIQEDDKLFIEKETKLNELTNKYEALKRD----YDAAVKDLESSREAVNQLTTQKDLV 759
+ Q+QE ++ + E ++ + + T ++EA ++D + A +++S + K +
Sbjct: 487 KVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL 546
Query: 760 EGRIAEL-ESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRD--LGEN-P 812
E R+ +L ES+ + E++ + + L E
Sbjct: 547 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH 606
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
K+ + I DS S+ ++RL S ++EL D++ L E + E+
Sbjct: 607 KVIAEKDKQIKQTEDSLASE-RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
Query: 873 ARLKKEKLSL---EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
L+K + S+ + ++ L+EQ++ E K + + D++ A L S V +
Sbjct: 666 HELEKMQQSVYVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKA-LKSEVQKLQTL 720
Query: 930 DAEVEKNKRLMKTIEE-LRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAEL 988
+E + NK +++ +E+ ++ K + LK ++ + + K++E A R E E+
Sbjct: 721 VSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 779
Query: 989 EELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-VDKLSNQKVA---LEKQIE 1044
++LK + + E K E+ ++K + LE + K++N++ L+++I+
Sbjct: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 839
Query: 1045 SLSNTPVSNSTMYVATGSAIVQN-QQITDVMKENQ 1078
+L + N + A +I Q++ +++K+ +
Sbjct: 840 ALKE-EIGNVQLEKAQQLSITSKVQELQNLLKKKK 873
Score = 53.2 bits (122), Expect = 5e-06
Identities = 99/529 (18%), Positives = 213/529 (40%), Gaps = 53/529 (10%)
Query: 48 QDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQ--- 103
+D+ CK + Q + N+ + ++ + ++++ + + K ETQ
Sbjct: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQ 405
Query: 104 -----TRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK-SKKINELQEENDTLSNLIMEN 157
R+ + ++I L+ EN + N T+ L++K S ++N+L+++ L N + E
Sbjct: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
Query: 158 V-------TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE--SENKIGPKNICAQCKLK 208
+ N + LK + ++ +++ + + +E++ +++ ++ K
Sbjct: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK 525
Query: 209 ENLIQSLHIGYDNTL---SKLNRSISD--SNTSTRYNKICTLQSELDAGREDCKELCEDF 263
EN +QSLH +TL +L + + + R NK +LQ ++ E + L
Sbjct: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
Query: 264 TSIKNHL--ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL--INNESK 319
+ + + + +L + + E ++ + ++ + L S E+L I N +
Sbjct: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K + + + A + + D+ I + L + + LN+
Sbjct: 646 LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 705
Query: 380 CTSELKSVNEKLASL-----NSQLIEKENACNILRIQK-ERIHEISSAVTIDIVKKENEL 433
LKS +KL +L N ++E+ C + +K + + E+ I + KE EL
Sbjct: 706 QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLE 493
I T+ S L ++ QDL A + + F +L+ EL + +E +
Sbjct: 766 NAIRTEN----SSLTKEV-----QDLKAKQNDQVSFASLVE--ELKKVIHE--------K 806
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDE 542
G K+V T+++ E+K+L EE+ + K +
Sbjct: 807 DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ 855
Score = 43.6 bits (98), Expect = 0.004
Identities = 56/276 (20%), Positives = 123/276 (44%), Gaps = 16/276 (5%)
Query: 814 LDDSPKRSISVISDSEVSQLKER---LLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
+ D+ K+S + + QL+E+ L + +++ K+R K+L E T E +
Sbjct: 315 IQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE---RSNV 371
Query: 871 QCARLKKEKLSLEQQVSNLKEQIRT--QQPVERQAKFADVAVNTDEDWANLHSVVVDRMS 928
R+K +LE++ + + +I Q+ + Q KF V + + A+L + +
Sbjct: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQE--NGIL 429
Query: 929 YDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
DA +L K EL +QD V ++ + K +++ + + + K +
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
Query: 988 LEELKQRYKELDE--ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
L+E ++R++E+ T Q++ Q K + + + KL++ V+ ++Q+E
Sbjct: 490 LQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-KQQLEQ 548
Query: 1046 LSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK 1081
+ + V ++ Q+ D++++N+ LK
Sbjct: 549 RLMQLMESEQKRVNKEESL--QMQVQDILEQNEALK 582
Score = 40.3 bits (90), Expect = 0.037
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Query: 39 ETQSNPIKLQDS--GTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ 96
E QS KL D+ + ++ Q ++ +N K E L ++ DI EQ AL+ + Q
Sbjct: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN-KEESLQMQVQDILEQNEALKAQIQ 586
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNL 153
+ + + L KDK+IK DSL ++ ++ +EE + N+
Sbjct: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
>BC050281-1|AAH50281.1| 1011|Homo sapiens PPFIBP1 protein protein.
Length = 1011
Score = 63.3 bits (147), Expect = 5e-09
Identities = 49/220 (22%), Positives = 112/220 (50%), Gaps = 14/220 (6%)
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ERL + + + L + L D+ E E +++ E C +EKL+ +++ L++++
Sbjct: 103 QERLARLENDKESLVLQVSVLTDQVEAQGEKIRDL-EFCLEEHREKLNATEEM--LQQEL 159
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDL 953
++ +E Q D+ L +V DR+ Y+ + + L++ I +LR K ++
Sbjct: 160 LSRTSLETQK--LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEM 217
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE 1013
+ + +K ++ + + + ++ + E + ++Q+++ L +E + E L+++E
Sbjct: 218 DSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKE 277
Query: 1014 EQCKRLKEAKI------ALEIVDK-LSNQKVALEKQIESL 1046
+ KRL+E + +EIVD+ + QK ++K +ESL
Sbjct: 278 SEVKRLQEKLVCKMKGEGVEIVDRDIEVQK--MKKAVESL 315
Score = 52.0 bits (119), Expect = 1e-05
Identities = 52/237 (21%), Positives = 119/237 (50%), Gaps = 11/237 (4%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+VS L +++ + +++ DL+ +E ++ E LQ+ L+ +KL L ++SN
Sbjct: 119 QVSVLTDQVEAQGEKIRDLEFCLEEHREKLNATEEMLQQELLSRTSLETQKLDLMAEISN 178
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
LK ++ + + + + D +T+ ++ + + D+E + ++ +K+ + L
Sbjct: 179 LKLKLTAVE--KDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMA 236
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE--CETCA 1006
K +K V +MQ EK + ++++E+ + EL K +LEE + K L E+ C+
Sbjct: 237 KLSSMKIKVGQMQ--YEK-QRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKG 293
Query: 1007 EYLK--QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
E ++ R+ + +++K+A +L ++ ++K+ E + L+ T+ +A G
Sbjct: 294 EGVEIVDRDIEVQKMKKAVESLMAANEEKDRKI--EDLRQCLNRYKKMQDTVVLAQG 348
Score = 41.5 bits (93), Expect = 0.016
Identities = 37/174 (21%), Positives = 75/174 (43%), Gaps = 3/174 (1%)
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
RDL+ L H++ + ++ Q LSRT E +K L E K
Sbjct: 135 RDLEFCLEEHREKLNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYE 194
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
F E E+ L +++++ ++ + L K L ++ ++KI + + + +
Sbjct: 195 DKFRDTEGLIQEINDLRLKVSEMDSERL-QYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQ 253
Query: 573 SLSEKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASEL-ERSCQVIK 624
+ +K L EL S L+E+ + +K L + + + + + E+ +R +V K
Sbjct: 254 RMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQK 307
Score = 35.5 bits (78), Expect = 1.1
Identities = 49/233 (21%), Positives = 112/233 (48%), Gaps = 20/233 (8%)
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMS 300
++ L +++A E ++L +F ++ H E M L ++L ET+ + +M+
Sbjct: 119 QVSVLTDQVEAQGEKIRDL--EFC-LEEHREKLNATEEM-LQQELLSRTSLETQKLDLMA 174
Query: 301 EIKRNLNSLSEQLINNESKKSKDHIDRYKDS---LLAVLDAEFGTTSLDVFEILMDNIIN 357
EI ++L +L E K D+ D+++D+ + + D + +D + + +
Sbjct: 175 EI----SNLKLKLTAVE-KDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLK 229
Query: 358 KYQ---IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+ L + K ++Q + + +S+ ++LASL QL EKE+ + R+Q++
Sbjct: 230 STKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKES--EVKRLQEKL 287
Query: 415 IHEISSAVTIDIVKKENELKEI--LTKECLKLSKLKIDIPRDLDQDLPAHKKI 465
+ ++ ++IV ++ E++++ + + ++ K DL Q L +KK+
Sbjct: 288 VCKMKGE-GVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKM 339
Score = 33.9 bits (74), Expect = 3.2
Identities = 49/227 (21%), Positives = 94/227 (41%), Gaps = 28/227 (12%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
LEE ++ + E L + S+ L+L+ EI LK+ + E+ L +K
Sbjct: 141 LEEHREKLNATEEMLQQELLSRTSLETQKLDLMA----EISNLKLKLTAVEKDRLDYEDK 196
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITRE-KETQASELERSCQVIKQNGFELDKMKAD 636
L+ IN L+ + + + S ++ K T++ + S IK + +K + +
Sbjct: 197 FRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRME 256
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI--KTHEKTAE 694
+ +SL ++ +LKEQ EEK + RL+ + K + E
Sbjct: 257 -------------------QKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVE 297
Query: 695 IQNR--MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
I +R + +++K ++ EK+ K+ +L K+ D V
Sbjct: 298 IVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVV 344
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 63.3 bits (147), Expect = 5e-09
Identities = 166/796 (20%), Positives = 324/796 (40%), Gaps = 73/796 (9%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK--EQKSAL 91
N IIE + ++L+D +T + K+ L+E + N +++ + EL + K E++S+
Sbjct: 335 NTKIIEEEKKTLELKDK--LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 92 EGKY-QNLILETQTRDLLMSQ-----IKSLEMENLTKDKEIKNLTDSL------KTKSKK 139
E K + E Q R+ SQ ++ +E E K ++++ D + + K +
Sbjct: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL 452
Query: 140 INE---LQEENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN- 194
I + EE T MEN S N+ D +K N + + I L+ ++ E
Sbjct: 453 IRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 512
Query: 195 --KIGP--KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD--SNTSTRYNKICT---L 245
++G + CA + E+L++ L + + + ++I++ S + + + T L
Sbjct: 513 KEELGLILEEKCALQRQLEDLVEELSFSREQ-IQRARQTIAEQESKLNEAHKSLSTVEDL 571
Query: 246 QSELDAGREDCKELC----EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK--VM 299
++E+ + E KEL + T+ K LE+ E LD ++ E+ E E + ++ ++
Sbjct: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD-RMAESQEAELERLRTQLL 630
Query: 300 SEIKRNLNSLSEQL-----INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+ L+ L E L IN E K KD++ + + L E + ++ + DN
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIE--KLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDN 687
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+I K + EI + Q +N + E+ +L L ++E L + +
Sbjct: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT-----ILF 469
+ + + + +KEN+L+E + + S LK D + L+ L H ++ I
Sbjct: 748 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILK-DEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 470 DALITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHN 523
D++ ++ + S + EIE E L+ + F+ +E
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E L + L SK + + +K L+EE+ +I + K E + E
Sbjct: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ ++++ L +V REK + L + +KQ E+ + ++
Sbjct: 927 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV----KS 982
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E + ++ N A Q C+ T+ S L+ + + AE + +
Sbjct: 983 LKQEKEQVSLRCRELEIIINHNRAENVQSCD--TQVSSLLDGVVTMTSRGAE---GSVSK 1037
Query: 703 LQKQIQEDDKLFIEKETKLNELT----NKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ K E+ K+ +E + +T +K E L D+ +V ESS A K
Sbjct: 1038 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRATQPSENDKLQ 1096
Query: 759 VEGRIAELESDIRTEQ 774
E + + E D+ +Q
Sbjct: 1097 KELNVLKSEQDLIRDQ 1112
Score = 60.9 bits (141), Expect = 2e-08
Identities = 153/818 (18%), Positives = 329/818 (40%), Gaps = 68/818 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ ++ + L + ++N T S S + LQ + L++ + + E D+L ++
Sbjct: 235 SQKLQIQFQQLQASETLRNSTHS----STAADLLQAKQQILTH--QQQLEEQDHL---LE 285
Query: 170 DLKKNNECLTQKCIDLEKLVN----ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
D +K E T + L++ + E + K+ N + + KE +I+ L+ + +
Sbjct: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNT---KIIEE 341
Query: 226 LNRSISDSNTSTRYNKIC-TLQSELDAGREDCKELCEDFTSIKN--HLELHEPNMTMDLD 282
+++ + T +K+ LQ ++ ++ K + + T+ K E M
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 401
Query: 283 EKLGENN----EFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
E+L + N +FET V+ M E +R L L +L + I + K L+
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHM 457
Query: 338 AEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ + M+N + Y I ++E K V +NE +L+ N + L
Sbjct: 458 AQMEEMKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKE 514
Query: 397 QL-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
+L + E C + R ++ + E+S S I ++ +E E K D+ +
Sbjct: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
+ + K++ + +A +T Y++ +EKEK + A++
Sbjct: 575 IVSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLRT----- 627
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 628 -QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF- 683
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 684 -EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
Query: 635 ADI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTH 689
++ L ++ L +N LK+ E+KT D ++ +
Sbjct: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQE 800
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESS 745
E+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 746 REAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXX 798
+ + + L KD +E + E + +++ A +
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
TF E ++GE + D + ++ E +L +RL ++ LK+++ E+
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLN 977
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
E QE+++ R ++ ++ + + + TQ
Sbjct: 978 EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
Score = 58.0 bits (134), Expect = 2e-07
Identities = 113/585 (19%), Positives = 247/585 (42%), Gaps = 48/585 (8%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLSEKDNKLTEL 584
S +E K+Y+ + D+ N N +I +E I+ L I + E+K L L +K +L
Sbjct: 299 SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 358
Query: 585 VSTING-LKEENNSLKSLNDVIT--REKETQASE----LERSCQVIKQNGFELDKMKADI 637
+ + + ++N +K++ +T ++KE Q+SE L + + +++ + + + DI
Sbjct: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ E + Q + +Q E + +++E +KT K E++N
Sbjct: 419 VQRMEQETQRKLEQLRA--ELDEMYGQQIVQMKQ-ELIRQHMAQME-EMKTRHK-GEMEN 473
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-K 756
+ + ED + +NEL K + + ++L E L Q +
Sbjct: 474 ALRSYSNITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
DLVE E R QT DL
Sbjct: 532 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV------------EDLKAEIVSAS 579
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETC-AEYLQERDEQCAR 874
++ + + ++EV+ K +L ++E + + +R E + E E + L +E+ ++
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 639
Query: 875 LKKEKLSLEQQVS--NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK E L +E +++ LK+ + + +++ + +++ + E
Sbjct: 640 LK-EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ K K L +++ + K +++ + ++QK +E +++KE +E+++ + + E L+
Sbjct: 699 ISKLKDLQQSL--VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 756
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
++ KE + + + E Q E + LK+ K LE + K+ + V+ E+++ L +
Sbjct: 757 KQMKEKENDLQ---EKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSK 812
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
+ V ++I +++EN+ LK+ +L +K+ T
Sbjct: 813 SKDS--------VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
Score = 51.6 bits (118), Expect = 2e-05
Identities = 81/313 (25%), Positives = 143/313 (45%), Gaps = 33/313 (10%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 664 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 780
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840
Query: 187 KLVNESEN--KIGPKNICAQC-KLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ + + N KN +L+E L + D SK + + + N+
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 244 TLQS-ELDAGREDCKELCEDFTSIKNHLELHE--PNMTMDLDEKLGENNEFETKAVKVMS 300
LQ + ED T + LE+ E T +L EKL TK K+
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE-----VTKREKL-- 953
Query: 301 EIKRNLNSLSEQL 313
E+ + L+ LSEQL
Sbjct: 954 ELSQRLSDLSEQL 966
Score = 46.8 bits (106), Expect = 4e-04
Identities = 108/523 (20%), Positives = 224/523 (42%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 364 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 423 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNI 481
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 541
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L TQ E +++L+ D+ E +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 662 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 717
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 718 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 772
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 875
Score = 44.0 bits (99), Expect = 0.003
Identities = 89/420 (21%), Positives = 180/420 (42%), Gaps = 50/420 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLE----INIKTHEKTAE--IQ-NRMIMRLQKQIQE 709
E + + L L EQ ++ +L+ + TH TA +Q + I+ Q+Q++E
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D L + + K + T + L+ V ++E ++ N + E I EL +
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTK 337
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
I E+ T+ +N+++ +N KL+ + + S E
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEI-KNMKLELTNSKQKERQSSEE 393
Query: 830 VSQL--------KERLLSCQQELDDLKERYKELDDECETCAEYLQER-DEQCARLKKEKL 880
+ QL K Q E D ++ +E + E L E +Q ++K+E +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 881 SLEQQVSNLKE-QIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMSY---DAEVEK 935
Q ++ ++E + R + +E + ++++ VN ED L +V ++ ++ D +K
Sbjct: 454 --RQHMAQMEEMKTRHKGEMENALRSYSNITVN--EDQIKLMNVAINELNIKLQDTNSQK 509
Query: 936 NK---RLMKTIEE---LRYKKQDLKNTVT----KMQKAMEKYTKKDKEFEAKRKEL---E 982
K L +EE L+ + +DL ++ ++Q+A + +++ + K L E
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-NQKVALEK 1041
D KAE+ + KEL+ + E K + E ++ K A ++D+++ +Q+ LE+
Sbjct: 570 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA-----VLDRMAESQEAELER 624
Score = 37.5 bits (83), Expect = 0.26
Identities = 47/221 (21%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE- 900
Q+L + + K+ D LQ+ + +E L L +Q L+ Q + Q E
Sbjct: 191 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250
Query: 901 -RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + A A+L +++ ++E+ L +E+ + KK+D ++
Sbjct: 251 LRNSTHSSTA-------ADLLQAKQQILTHQQQLEEQDHL---LEDYQKKKEDFTMQISF 300
Query: 960 MQKAMEKY-TKKDKEFEAKRKE--------LEDCKAELEELKQRYKELDEECETCAEYLK 1010
+Q+ ++ Y ++DK+ E KE +E+ ++ E +++ EL ++ T + L
Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360
Query: 1011 QREEQ-CKRLKEAK-IALEIVDKLSNQKVALEKQIESLSNT 1049
+ +EQ ++ +E K + LE+ + ++ + E +I+ L T
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSE-EIKQLMGT 400
>AB033056-1|BAA86544.2| 932|Homo sapiens KIAA1230 protein protein.
Length = 932
Score = 63.3 bits (147), Expect = 5e-09
Identities = 49/220 (22%), Positives = 112/220 (50%), Gaps = 14/220 (6%)
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ERL + + + L + L D+ E E +++ E C +EKL+ +++ L++++
Sbjct: 24 QERLARLENDKESLVLQVSVLTDQVEAQGEKIRDL-EFCLEEHREKLNATEEM--LQQEL 80
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDL 953
++ +E Q D+ L +V DR+ Y+ + + L++ I +LR K ++
Sbjct: 81 LSRTSLETQK--LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEM 138
Query: 954 KNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE 1013
+ + +K ++ + + + ++ + E + ++Q+++ L +E + E L+++E
Sbjct: 139 DSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKE 198
Query: 1014 EQCKRLKEAKI------ALEIVDK-LSNQKVALEKQIESL 1046
+ KRL+E + +EIVD+ + QK ++K +ESL
Sbjct: 199 SEVKRLQEKLVCKMKGEGVEIVDRDIEVQK--MKKAVESL 236
Score = 52.0 bits (119), Expect = 1e-05
Identities = 52/237 (21%), Positives = 119/237 (50%), Gaps = 11/237 (4%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSN 888
+VS L +++ + +++ DL+ +E ++ E LQ+ L+ +KL L ++SN
Sbjct: 40 QVSVLTDQVEAQGEKIRDLEFCLEEHREKLNATEEMLQQELLSRTSLETQKLDLMAEISN 99
Query: 889 LKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRY 948
LK ++ + + + + D +T+ ++ + + D+E + ++ +K+ + L
Sbjct: 100 LKLKLTAVE--KDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMA 157
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE--CETCA 1006
K +K V +MQ EK + ++++E+ + EL K +LEE + K L E+ C+
Sbjct: 158 KLSSMKIKVGQMQ--YEK-QRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKG 214
Query: 1007 EYLK--QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATG 1061
E ++ R+ + +++K+A +L ++ ++K+ E + L+ T+ +A G
Sbjct: 215 EGVEIVDRDIEVQKMKKAVESLMAANEEKDRKI--EDLRQCLNRYKKMQDTVVLAQG 269
Score = 41.5 bits (93), Expect = 0.016
Identities = 37/174 (21%), Positives = 75/174 (43%), Gaps = 3/174 (1%)
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXX 512
RDL+ L H++ + ++ Q LSRT E +K L E K
Sbjct: 56 RDLEFCLEEHREKLNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYE 115
Query: 513 XXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKML 572
F E E+ L +++++ ++ + L K L ++ ++KI + + + +
Sbjct: 116 DKFRDTEGLIQEINDLRLKVSEMDSERL-QYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQ 174
Query: 573 SLSEKDNKL-TELVSTINGLKEENNSLKSLNDVITREKETQASEL-ERSCQVIK 624
+ +K L EL S L+E+ + +K L + + + + + E+ +R +V K
Sbjct: 175 RMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQK 228
Score = 35.5 bits (78), Expect = 1.1
Identities = 49/233 (21%), Positives = 112/233 (48%), Gaps = 20/233 (8%)
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMS 300
++ L +++A E ++L +F ++ H E M L ++L ET+ + +M+
Sbjct: 40 QVSVLTDQVEAQGEKIRDL--EFC-LEEHREKLNATEEM-LQQELLSRTSLETQKLDLMA 95
Query: 301 EIKRNLNSLSEQLINNESKKSKDHIDRYKDS---LLAVLDAEFGTTSLDVFEILMDNIIN 357
EI ++L +L E K D+ D+++D+ + + D + +D + + +
Sbjct: 96 EI----SNLKLKLTAVE-KDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLK 150
Query: 358 KYQ---IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+ L + K ++Q + + +S+ ++LASL QL EKE+ + R+Q++
Sbjct: 151 STKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKES--EVKRLQEKL 208
Query: 415 IHEISSAVTIDIVKKENELKEI--LTKECLKLSKLKIDIPRDLDQDLPAHKKI 465
+ ++ ++IV ++ E++++ + + ++ K DL Q L +KK+
Sbjct: 209 VCKMKGE-GVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKM 260
Score = 33.9 bits (74), Expect = 3.2
Identities = 49/227 (21%), Positives = 94/227 (41%), Gaps = 28/227 (12%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
LEE ++ + E L + S+ L+L+ EI LK+ + E+ L +K
Sbjct: 62 LEEHREKLNATEEMLQQELLSRTSLETQKLDLMA----EISNLKLKLTAVEKDRLDYEDK 117
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITRE-KETQASELERSCQVIKQNGFELDKMKAD 636
L+ IN L+ + + + S ++ K T++ + S IK + +K + +
Sbjct: 118 FRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRME 177
Query: 637 ILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI--KTHEKTAE 694
+ +SL ++ +LKEQ EEK + RL+ + K + E
Sbjct: 178 -------------------QKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVE 218
Query: 695 IQNR--MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAV 739
I +R + +++K ++ EK+ K+ +L K+ D V
Sbjct: 219 IVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVV 265
>BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/CAST
family member 2 protein.
Length = 957
Score = 62.5 bits (145), Expect = 8e-09
Identities = 119/581 (20%), Positives = 240/581 (41%), Gaps = 63/581 (10%)
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
L EE + +++ D L L++ EE++ L+I K +L+ +D + +L+
Sbjct: 258 LTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQ-----TLNARDESIKKLLEM 311
Query: 588 INGLKEENNSLKSLNDVITR--EKETQASELERSCQVIKQNGFEL--DKMKADILMXXXX 643
+ + SL+ N+ R E E+Q S LE ++ L + + L
Sbjct: 312 LQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 371
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLA--------LKEQCEEKTRDCSRLEINIKTHEKTAEI 695
D + LE+N+ LK T D I+ ++ ++
Sbjct: 372 KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKF 431
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
I +L++++ + + + +TKL L+N+ K+ + + L + + L T+
Sbjct: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTE 491
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
D + R+ E ES + + T E RD+ + ++
Sbjct: 492 VDALRLRLEEKESFLNKK--------------TKQLQDLTEEKGTLAGEIRDMKDMLEVK 537
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ R I+V+ ++ L+E+L ++L +LK+R K L + L +E A
Sbjct: 538 E---RKINVLQ-KKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEE--ALS 591
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+KE++ + LKEQ R + ER + + ++++ + ++ +
Sbjct: 592 EKERI-----IERLKEQ-RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 936 NKRLMKTIEELRYKKQD-LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K ++ K+ LK+ +++ E+ +K + + + K +ED E +
Sbjct: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDDSRMNPEFADQ 704
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNS 1054
K+LD+E A Y R+E K E LEI+ ++ N+K +K+I L + + +
Sbjct: 705 IKQLDKE----ASYY--RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHM 758
Query: 1055 TMYVATGSAIVQNQQITDVMKENQKL-KKMNAKLITICKKR 1094
QN+++ + +K NQ+L KK NA+L+ ++R
Sbjct: 759 KD---------QNKKVAN-LKHNQQLEKKKNAQLLEEVRRR 789
Score = 58.8 bits (136), Expect = 1e-07
Identities = 96/554 (17%), Positives = 227/554 (40%), Gaps = 33/554 (5%)
Query: 517 TLEEAHNEVKSLHEELTK--LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
TL +K L E L L ++++N + ++ L++ + + E++ + L
Sbjct: 297 TLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHL 356
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E+ ++ ++L K ++ + D E +LE Q++K NG + +
Sbjct: 357 REELHRRSQLQPEPAKTKALQTVIE-MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR 415
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQN----LALKEQCEEKTRDCSRLEINIKTHE 690
+ + D+ K L + LAL+ + E + S + +I+ +
Sbjct: 416 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK 475
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
++ + + LQ ++ EKE+ LN+ T + + L + ++ ++ +
Sbjct: 476 ESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 535
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDENR 806
+ ++++ +I L+ +R + T ++ R
Sbjct: 536 VKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER 595
Query: 807 ---DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L E + DD + E LKE++ + Q EL + + +L + + A
Sbjct: 596 IIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLAS 655
Query: 864 YLQERDEQCARLKKEKLSLEQ---QVSNLKEQIRTQQPVERQAK----FADVAVNTDEDW 916
+RD ++LK ++++EQ + S L+ Q++ +E ++ FAD D++
Sbjct: 656 AGLKRD---SKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE- 711
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ + + AEV+ RL++ ++E+ +K D + +++ ++ K + A
Sbjct: 712 ASYYRDECGKA--QAEVD---RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 766
Query: 977 KRKELEDC-KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD-KLSN 1034
K + K + +L + + ++ +++L Q EE L++ + L+ +L++
Sbjct: 767 NLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-QIEELMNALEKTRQELDATKARLAS 825
Query: 1035 QKVALEKQIESLSN 1048
+ +L ++ L+N
Sbjct: 826 TQQSLAEKEAHLAN 839
Score = 58.0 bits (134), Expect = 2e-07
Identities = 149/745 (20%), Positives = 313/745 (42%), Gaps = 67/745 (8%)
Query: 46 KLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEGKYQNLILET 102
+++DS + + ++ + +E+ E+++K KL + IK S K + L E
Sbjct: 141 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEE 200
Query: 103 QTR-DLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES 161
R +L Q++ EN I+ L D L+T+ + LQ+E+ N E+ T
Sbjct: 201 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQES---GNRGAEHFT-I 256
Query: 162 DNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN 221
+ + L+ ++ ++ L K + E E +I + + E++ + L +
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSK 315
Query: 222 TLSKLNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
L ++S+ D N TR +++ L+ LD ++ L E+ ++ L+ EP
Sbjct: 316 GLP--SKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR-RSQLQ-PEPA 371
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ---LINNESKKSKDHIDRYKDSLL 333
T L + E K K+ S ++RN+ L ++ L N ++D + K +
Sbjct: 372 KTKALQTVI------EMKDTKIAS-LERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 424
Query: 334 AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
++F T +D + ++K + +L + K + ++C ++ + E L +
Sbjct: 425 YKSHSKFMKTKID----QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
+ + + LR+ R+ E S + KK +L++ LT+E L +I R
Sbjct: 481 KEQRAAILQTEVDALRL---RLEEKESFLN----KKTKQLQD-LTEE---KGTLAGEI-R 528
Query: 454 DLDQDLPA-HKKITILFDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXX 511
D+ L +KI +L + Q +L D ++ K R+ K++
Sbjct: 529 DMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRV-----KSLQTDSSNTDTAL 583
Query: 512 XXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
+ L E ++ L E+ + + +++E + K L E+++AL+ + + E +
Sbjct: 584 ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
+ L E + L GLK + + LKSL I ++KE + S+LE Q+ K + E D
Sbjct: 644 IDLKEHASSLASA-----GLKRD-SKLKSLEIAIEQKKE-ECSKLE--AQLKKAHNIEDD 694
Query: 632 -KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+M + +A++ +++ L + ++ E + D + +++
Sbjct: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754
Query: 691 -KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+ + QN+ + L+ Q + K K +L E + E D ++ +E A+
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKK----KNAQLLEEVRRREDSMADNSQHLQ-IEELMNAL 809
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQ 774
+ + D + R+A + + ++
Sbjct: 810 EKTRQELDATKARLASTQQSLAEKE 834
Score = 55.2 bits (127), Expect = 1e-06
Identities = 90/423 (21%), Positives = 194/423 (45%), Gaps = 46/423 (10%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA-LEGKYQ 96
I+ + ++S + + K+ ++L +++ +E L E KEQ++A L+ +
Sbjct: 436 IDQLKQELSKKESELLALQTKL-ETLSNQNSDCKQHIEVLK-ESLTAKEQRAAILQTEVD 493
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDK-----EIKNLTDSLKTKSKKINELQEENDTLS 151
L L + ++ +++ K+ ++++LT++K EI+++ D L+ K +KIN LQ++ + L
Sbjct: 494 ALRLRLEEKESFLNK-KTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQ 552
Query: 152 NLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENL 211
+ + + NL V L+ ++ LE+ ++E E I +LKE
Sbjct: 553 EQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIE--------RLKEQR 604
Query: 212 IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE 271
+ D + S N + K+ LQ+EL +L E +S+ +
Sbjct: 605 ERD-----DRERLEEIESFRKENKDLK-EKVNALQAELTEKESSLIDLKEHASSLAS-AG 657
Query: 272 LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK-- 329
L + L+ + + E + K+ +++K+ N I ++S+ + + D+ K
Sbjct: 658 LKRDSKLKSLEIAIEQKKE---ECSKLEAQLKKAHN------IEDDSRMNPEFADQIKQL 708
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT-SELKSVN 388
D + E G +V +L I+ + + +E +K K+ +L T +K N
Sbjct: 709 DKEASYYRDECGKAQAEVDRLL--EILKEVE---NEKNDKDKKI-AELESLTLRHMKDQN 762
Query: 389 EKLASL--NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSK 446
+K+A+L N QL +K+NA + +++ ++ + I + N L++ T++ L +K
Sbjct: 763 KKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEK--TRQELDATK 820
Query: 447 LKI 449
++
Sbjct: 821 ARL 823
Score = 54.4 bits (125), Expect = 2e-06
Identities = 139/703 (19%), Positives = 283/703 (40%), Gaps = 56/703 (7%)
Query: 43 NPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF----DIKEQKSALEGKYQNL 98
N + Q+SG + +E+ + + ++ + ELF ++E + +E + Q L
Sbjct: 239 NHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL 298
Query: 99 ILETQT-RDLL-MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIME 156
++ + LL M Q K L ++L D E +++ + + ++ + + + E
Sbjct: 299 NARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLRE 358
Query: 157 NVTESDNLNKEVDDLKKNN---ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ 213
+ L E K E K LE+ + + E++I ++ +
Sbjct: 359 ELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
I + SK ++ D K +SEL A + + L + K H+E+
Sbjct: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKK----ESELLALQTKLETLSNQNSDCKQHIEVL 474
Query: 274 EPNMTMDLDEKLGENNEFETKAVKVMSEIKRN-LNSLSEQL--INNESKKSKDHIDRYKD 330
+ ++T E+ + E A+++ E K + LN ++QL + E I KD
Sbjct: 475 KESLTAK--EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L E ++V + ++N+ + + D D+ L T ++ + ++ + +
Sbjct: 533 ML------EVKERKINVLQKKIENLQEQLR-DKDKQL---TNLKDRVKSLQTDSSNTDTA 582
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-ELKEILTKECLKLSKLKI 449
LA+L L EKE L+ Q+ER + I+ +KEN +LKE + +L++ +
Sbjct: 583 LATLEEALSEKERIIERLKEQRER-DDRERLEEIESFRKENKDLKEKVNALQAELTEKES 641
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
+ DL + + + D+ + E++ + E KL + A +
Sbjct: 642 SL-IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE 700
Query: 510 XXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE 569
D +++ E +E K +++VD L ++K + E + IA+ E
Sbjct: 701 FA----DQIKQLDKEASYYRDECGKA-QAEVDR---LLEILKEVENEKNDKDKKIAELES 752
Query: 570 KMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE----KETQASELERSCQVIKQ 625
L + NK + L+++ N+ + L +V RE +Q ++E +++
Sbjct: 753 LTLRHMKDQNKKVANLKHNQQLEKKKNA-QLLEEVRRREDSMADNSQHLQIEELMNALEK 811
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC-----EEKTRDCS 680
ELD KA + E + LE+ L +K++ EK + +
Sbjct: 812 TRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIA 871
Query: 681 RLEINIKTHEKTAE-------IQNRMIMRLQKQIQEDDKLFIE 716
LE++ +KT E ++R++ +L++Q Q KL +
Sbjct: 872 LLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 49.2 bits (112), Expect = 8e-05
Identities = 161/800 (20%), Positives = 314/800 (39%), Gaps = 92/800 (11%)
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQS-ELDAGREDCKELCEDFTSIKNHLEL-HEPNM 277
+N L + I DS + N I T S EL R KE + +K + + HE N
Sbjct: 160 ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQ 219
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID-RYKDSLLAVL 336
+ L +A++ +R+LN L +Q N + +H + L
Sbjct: 220 HLQLT----------IQALQDELRTQRDLNHLLQQESGN---RGAEHFTIELTEENFRRL 266
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS--L 394
AE + ++F L+ + + ++ ++ +K T LN +K + E L S L
Sbjct: 267 QAEHDRQAKELF--LLRKTLEEMELRIET--QKQT-----LNARDESIKKLLEMLQSKGL 317
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVT-IDIVKKENELKEI-LTKECLKLSKLKIDIP 452
S+ +E +N + R+ E S V+ ++++ + E + I L +E + S+L+ +
Sbjct: 318 PSKSLEDDNE------RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 371
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR----LETGTAKAVXXXXXXXX 508
+ A + + + D I E + D E E + L+ L T +
Sbjct: 372 KT-----KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYK 426
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+++ E+ EL L +N N + + I+ LK ++ E
Sbjct: 427 SHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC----KQHIEVLKESLTAKE 482
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
++ L + + L + N K L D +T EK T A E+ ++
Sbjct: 483 QRAAILQTEVDALRLRLEEKESFL--NKKTKQLQD-LTEEKGTLAGEIRDMKDML----- 534
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E+ + K ++L D+ K L LK++ + D S + + T
Sbjct: 535 EVKERKINVLQKKIENLQEQLR-----DKDKQLTN----LKDRVKSLQTDSSNTDTALAT 585
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIE------KETK-LNELTNKYEALKRDYDAAVKD 741
E+ + R+I RL++Q + DD+ +E KE K L E N +A + ++++ D
Sbjct: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L+ ++ ++D ++ LE I ++ F
Sbjct: 646 LKEHASSLASAGLKRD---SKLKSLEIAIE-QKKEECSKLEAQLKKAHNIEDDSRMNPEF 701
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
D+ + L + + S R + +EV +L E L + E +D ++ EL+
Sbjct: 702 ADQIKQLDK----EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELE---SLT 754
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
++++++++ A LK + +++ + L E++R R+ AD + + + +++
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVR-----RREDSMADNSQHLQIE-ELMNA 808
Query: 922 VVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ R DA RL T + L K+ L N + +K +E+ + +E
Sbjct: 809 LEKTRQELDA---TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISE 865
Query: 982 EDCKAELEELKQRYKELDEE 1001
+D L EL K+ +E
Sbjct: 866 KDANIALLELSASKKKKTQE 885
Score = 37.1 bits (82), Expect = 0.35
Identities = 71/326 (21%), Positives = 134/326 (41%), Gaps = 32/326 (9%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGT---ITISCKMCQSLKESSNEINLKLEKLSGELFD 83
L+ A S+ + IIE + D I K + LKE N + +L + L D
Sbjct: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINEL 143
+KE S+L RD S++KSLE+ K +E L LK K+ I +
Sbjct: 646 LKEHASSLAS-------AGLKRD---SKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDD 694
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
N ++ I + E+ E + + L + ++E N+ + KI
Sbjct: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754
Query: 204 QCKLKENLIQSLHIGYDNTLSK---------LNRSISDSNTSTRYNKICTLQSELDAGRE 254
+K+ + ++ ++ L K + R ++++ +I L + L+ R+
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQ 814
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKA-VKVMSEIKRNLNSLS 310
+ S + L E H N+ ++ ++L E E + +A + +SE N+ L
Sbjct: 815 ELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALL- 873
Query: 311 EQLINNESKKSKDHI---DRYKDSLL 333
+L ++ KK+++ + R KD L+
Sbjct: 874 -ELSASKKKKTQEEVMALKREKDRLV 898
>BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein.
Length = 957
Score = 62.5 bits (145), Expect = 8e-09
Identities = 119/581 (20%), Positives = 240/581 (41%), Gaps = 63/581 (10%)
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
L EE + +++ D L L++ EE++ L+I K +L+ +D + +L+
Sbjct: 258 LTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQ-----TLNARDESIKKLLEM 311
Query: 588 INGLKEENNSLKSLNDVITR--EKETQASELERSCQVIKQNGFEL--DKMKADILMXXXX 643
+ + SL+ N+ R E E+Q S LE ++ L + + L
Sbjct: 312 LQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 371
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLA--------LKEQCEEKTRDCSRLEINIKTHEKTAEI 695
D + LE+N+ LK T D I+ ++ ++
Sbjct: 372 KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKF 431
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
I +L++++ + + + +TKL L+N+ K+ + + L + + L T+
Sbjct: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTE 491
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
D + R+ E ES + + T E RD+ + ++
Sbjct: 492 VDALRLRLEEKESFLNKK--------------TKQLQDLTEEKGTLAGEIRDMKDMLEVK 537
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ R I+V+ ++ L+E+L ++L +LK+R K L + L +E A
Sbjct: 538 E---RKINVLQ-KKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEE--ALS 591
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+KE++ + LKEQ R + ER + + ++++ + ++ +
Sbjct: 592 EKERI-----IERLKEQ-RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 936 NKRLMKTIEELRYKKQD-LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K ++ K+ LK+ +++ E+ +K + + + K +ED E +
Sbjct: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDDSRMNPEFADQ 704
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNS 1054
K+LD+E A Y R+E K E LEI+ ++ N+K +K+I L + + +
Sbjct: 705 IKQLDKE----ASYY--RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHM 758
Query: 1055 TMYVATGSAIVQNQQITDVMKENQKL-KKMNAKLITICKKR 1094
QN+++ + +K NQ+L KK NA+L+ ++R
Sbjct: 759 KD---------QNKKVAN-LKHNQQLEKKKNAQLLEEVRRR 789
Score = 58.8 bits (136), Expect = 1e-07
Identities = 96/554 (17%), Positives = 227/554 (40%), Gaps = 33/554 (5%)
Query: 517 TLEEAHNEVKSLHEELTK--LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
TL +K L E L L ++++N + ++ L++ + + E++ + L
Sbjct: 297 TLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHL 356
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E+ ++ ++L K ++ + D E +LE Q++K NG + +
Sbjct: 357 REELHRRSQLQPEPAKTKALQTVIE-MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR 415
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQN----LALKEQCEEKTRDCSRLEINIKTHE 690
+ + D+ K L + LAL+ + E + S + +I+ +
Sbjct: 416 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK 475
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
++ + + LQ ++ EKE+ LN+ T + + L + ++ ++ +
Sbjct: 476 ESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 535
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDENR 806
+ ++++ +I L+ +R + T ++ R
Sbjct: 536 VKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER 595
Query: 807 ---DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L E + DD + E LKE++ + Q EL + + +L + + A
Sbjct: 596 IIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLAS 655
Query: 864 YLQERDEQCARLKKEKLSLEQ---QVSNLKEQIRTQQPVERQAK----FADVAVNTDEDW 916
+RD ++LK ++++EQ + S L+ Q++ +E ++ FAD D++
Sbjct: 656 AGLKRD---SKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE- 711
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ + + AEV+ RL++ ++E+ +K D + +++ ++ K + A
Sbjct: 712 ASYYRDECGKA--QAEVD---RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 766
Query: 977 KRKELEDC-KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD-KLSN 1034
K + K + +L + + ++ +++L Q EE L++ + L+ +L++
Sbjct: 767 NLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-QIEELMNALEKTRQELDATKARLAS 825
Query: 1035 QKVALEKQIESLSN 1048
+ +L ++ L+N
Sbjct: 826 TQQSLAEKEAHLAN 839
Score = 58.0 bits (134), Expect = 2e-07
Identities = 149/745 (20%), Positives = 313/745 (42%), Gaps = 67/745 (8%)
Query: 46 KLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEGKYQNLILET 102
+++DS + + ++ + +E+ E+++K KL + IK S K + L E
Sbjct: 141 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEE 200
Query: 103 QTR-DLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES 161
R +L Q++ EN I+ L D L+T+ + LQ+E+ N E+ T
Sbjct: 201 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQES---GNRGAEHFT-I 256
Query: 162 DNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN 221
+ + L+ ++ ++ L K + E E +I + + E++ + L +
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSK 315
Query: 222 TLSKLNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
L ++S+ D N TR +++ L+ LD ++ L E+ ++ L+ EP
Sbjct: 316 GLP--SKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR-RSQLQ-PEPA 371
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ---LINNESKKSKDHIDRYKDSLL 333
T L + E K K+ S ++RN+ L ++ L N ++D + K +
Sbjct: 372 KTKALQTVI------EMKDTKIAS-LERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 424
Query: 334 AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
++F T +D + ++K + +L + K + ++C ++ + E L +
Sbjct: 425 YKSHSKFMKTKID----QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
+ + + LR+ R+ E S + KK +L++ LT+E L +I R
Sbjct: 481 KEQRAAILQTEVDALRL---RLEEKESFLN----KKTKQLQD-LTEE---KGTLAGEI-R 528
Query: 454 DLDQDLPA-HKKITILFDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXX 511
D+ L +KI +L + Q +L D ++ K R+ K++
Sbjct: 529 DMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRV-----KSLQTDSSNTDTAL 583
Query: 512 XXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
+ L E ++ L E+ + + +++E + K L E+++AL+ + + E +
Sbjct: 584 ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
+ L E + L GLK + + LKSL I ++KE + S+LE Q+ K + E D
Sbjct: 644 IDLKEHASSLASA-----GLKRD-SKLKSLEIAIEQKKE-ECSKLE--AQLKKAHNIEDD 694
Query: 632 -KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+M + +A++ +++ L + ++ E + D + +++
Sbjct: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754
Query: 691 -KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+ + QN+ + L+ Q + K K +L E + E D ++ +E A+
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKK----KNAQLLEEVRRREDSMADNSQHLQ-IEELMNAL 809
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQ 774
+ + D + R+A + + ++
Sbjct: 810 EKTRQELDATKARLASTQQSLAEKE 834
Score = 55.2 bits (127), Expect = 1e-06
Identities = 90/423 (21%), Positives = 194/423 (45%), Gaps = 46/423 (10%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA-LEGKYQ 96
I+ + ++S + + K+ ++L +++ +E L E KEQ++A L+ +
Sbjct: 436 IDQLKQELSKKESELLALQTKL-ETLSNQNSDCKQHIEVLK-ESLTAKEQRAAILQTEVD 493
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDK-----EIKNLTDSLKTKSKKINELQEENDTLS 151
L L + ++ +++ K+ ++++LT++K EI+++ D L+ K +KIN LQ++ + L
Sbjct: 494 ALRLRLEEKESFLNK-KTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQ 552
Query: 152 NLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENL 211
+ + + NL V L+ ++ LE+ ++E E I +LKE
Sbjct: 553 EQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIE--------RLKEQR 604
Query: 212 IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE 271
+ D + S N + K+ LQ+EL +L E +S+ +
Sbjct: 605 ERD-----DRERLEEIESFRKENKDLK-EKVNALQAELTEKESSLIDLKEHASSLAS-AG 657
Query: 272 LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK-- 329
L + L+ + + E + K+ +++K+ N I ++S+ + + D+ K
Sbjct: 658 LKRDSKLKSLEIAIEQKKE---ECSKLEAQLKKAHN------IEDDSRMNPEFADQIKQL 708
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT-SELKSVN 388
D + E G +V +L I+ + + +E +K K+ +L T +K N
Sbjct: 709 DKEASYYRDECGKAQAEVDRLL--EILKEVE---NEKNDKDKKI-AELESLTLRHMKDQN 762
Query: 389 EKLASL--NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSK 446
+K+A+L N QL +K+NA + +++ ++ + I + N L++ T++ L +K
Sbjct: 763 KKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEK--TRQELDATK 820
Query: 447 LKI 449
++
Sbjct: 821 ARL 823
Score = 54.4 bits (125), Expect = 2e-06
Identities = 139/703 (19%), Positives = 283/703 (40%), Gaps = 56/703 (7%)
Query: 43 NPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF----DIKEQKSALEGKYQNL 98
N + Q+SG + +E+ + + ++ + ELF ++E + +E + Q L
Sbjct: 239 NHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL 298
Query: 99 ILETQT-RDLL-MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIME 156
++ + LL M Q K L ++L D E +++ + + ++ + + + E
Sbjct: 299 NARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLRE 358
Query: 157 NVTESDNLNKEVDDLKKNN---ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ 213
+ L E K E K LE+ + + E++I ++ +
Sbjct: 359 ELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
I + SK ++ D K +SEL A + + L + K H+E+
Sbjct: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKK----ESELLALQTKLETLSNQNSDCKQHIEVL 474
Query: 274 EPNMTMDLDEKLGENNEFETKAVKVMSEIKRN-LNSLSEQL--INNESKKSKDHIDRYKD 330
+ ++T E+ + E A+++ E K + LN ++QL + E I KD
Sbjct: 475 KESLTAK--EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L E ++V + ++N+ + + D D+ L T ++ + ++ + +
Sbjct: 533 ML------EVKERKINVLQKKIENLQEQLR-DKDKQL---TNLKDRVKSLQTDSSNTDTA 582
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-ELKEILTKECLKLSKLKI 449
LA+L L EKE L+ Q+ER + I+ +KEN +LKE + +L++ +
Sbjct: 583 LATLEEALSEKERIIERLKEQRER-DDRERLEEIESFRKENKDLKEKVNALQAELTEKES 641
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
+ DL + + + D+ + E++ + E KL + A +
Sbjct: 642 SL-IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE 700
Query: 510 XXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE 569
D +++ E +E K +++VD L ++K + E + IA+ E
Sbjct: 701 FA----DQIKQLDKEASYYRDECGKA-QAEVDR---LLEILKEVENEKNDKDKKIAELES 752
Query: 570 KMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE----KETQASELERSCQVIKQ 625
L + NK + L+++ N+ + L +V RE +Q ++E +++
Sbjct: 753 LTLRHMKDQNKKVANLKHNQQLEKKKNA-QLLEEVRRREDSMADNSQHLQIEELMNALEK 811
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC-----EEKTRDCS 680
ELD KA + E + LE+ L +K++ EK + +
Sbjct: 812 TRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIA 871
Query: 681 RLEINIKTHEKTAE-------IQNRMIMRLQKQIQEDDKLFIE 716
LE++ +KT E ++R++ +L++Q Q KL +
Sbjct: 872 LLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 49.2 bits (112), Expect = 8e-05
Identities = 161/800 (20%), Positives = 314/800 (39%), Gaps = 92/800 (11%)
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQS-ELDAGREDCKELCEDFTSIKNHLEL-HEPNM 277
+N L + I DS + N I T S EL R KE + +K + + HE N
Sbjct: 160 ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQ 219
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID-RYKDSLLAVL 336
+ L +A++ +R+LN L +Q N + +H + L
Sbjct: 220 HLQLT----------IQALQDELRTQRDLNHLLQQESGN---RGAEHFTIELTEENFRRL 266
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS--L 394
AE + ++F L+ + + ++ ++ +K T LN +K + E L S L
Sbjct: 267 QAEHDRQAKELF--LLRKTLEEMELRIET--QKQT-----LNARDESIKKLLEMLQSKGL 317
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVT-IDIVKKENELKEI-LTKECLKLSKLKIDIP 452
S+ +E +N + R+ E S V+ ++++ + E + I L +E + S+L+ +
Sbjct: 318 PSKSLEDDNE------RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 371
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR----LETGTAKAVXXXXXXXX 508
+ A + + + D I E + D E E + L+ L T +
Sbjct: 372 KT-----KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYK 426
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+++ E+ EL L +N N + + I+ LK ++ E
Sbjct: 427 SHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC----KQHIEVLKESLTAKE 482
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
++ L + + L + N K L D +T EK T A E+ ++
Sbjct: 483 QRAAILQTEVDALRLRLEEKESFL--NKKTKQLQD-LTEEKGTLAGEIRDMKDML----- 534
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E+ + K ++L D+ K L LK++ + D S + + T
Sbjct: 535 EVKERKINVLQKKIENLQEQLR-----DKDKQLTN----LKDRVKSLQTDSSNTDTALAT 585
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIE------KETK-LNELTNKYEALKRDYDAAVKD 741
E+ + R+I RL++Q + DD+ +E KE K L E N +A + ++++ D
Sbjct: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L+ ++ ++D ++ LE I ++ F
Sbjct: 646 LKEHASSLASAGLKRD---SKLKSLEIAIE-QKKEECSKLEAQLKKAHNIEDDSRMNPEF 701
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
D+ + L + + S R + +EV +L E L + E +D ++ EL+
Sbjct: 702 ADQIKQLDK----EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELE---SLT 754
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
++++++++ A LK + +++ + L E++R R+ AD + + + +++
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVR-----RREDSMADNSQHLQIE-ELMNA 808
Query: 922 VVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ R DA RL T + L K+ L N + +K +E+ + +E
Sbjct: 809 LEKTRQELDA---TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISE 865
Query: 982 EDCKAELEELKQRYKELDEE 1001
+D L EL K+ +E
Sbjct: 866 KDANIALLELSASKKKKTQE 885
Score = 37.1 bits (82), Expect = 0.35
Identities = 71/326 (21%), Positives = 134/326 (41%), Gaps = 32/326 (9%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGT---ITISCKMCQSLKESSNEINLKLEKLSGELFD 83
L+ A S+ + IIE + D I K + LKE N + +L + L D
Sbjct: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINEL 143
+KE S+L RD S++KSLE+ K +E L LK K+ I +
Sbjct: 646 LKEHASSLAS-------AGLKRD---SKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDD 694
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
N ++ I + E+ E + + L + ++E N+ + KI
Sbjct: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754
Query: 204 QCKLKENLIQSLHIGYDNTLSK---------LNRSISDSNTSTRYNKICTLQSELDAGRE 254
+K+ + ++ ++ L K + R ++++ +I L + L+ R+
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQ 814
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKA-VKVMSEIKRNLNSLS 310
+ S + L E H N+ ++ ++L E E + +A + +SE N+ L
Sbjct: 815 ELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALL- 873
Query: 311 EQLINNESKKSKDHI---DRYKDSLL 333
+L ++ KK+++ + R KD L+
Sbjct: 874 -ELSASKKKKTQEEVMALKREKDRLV 898
>AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein.
Length = 970
Score = 62.5 bits (145), Expect = 8e-09
Identities = 119/581 (20%), Positives = 240/581 (41%), Gaps = 63/581 (10%)
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
L EE + +++ D L L++ EE++ L+I K +L+ +D + +L+
Sbjct: 271 LTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQ-----TLNARDESIKKLLEM 324
Query: 588 INGLKEENNSLKSLNDVITR--EKETQASELERSCQVIKQNGFEL--DKMKADILMXXXX 643
+ + SL+ N+ R E E+Q S LE ++ L + + L
Sbjct: 325 LQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 384
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLA--------LKEQCEEKTRDCSRLEINIKTHEKTAEI 695
D + LE+N+ LK T D I+ ++ ++
Sbjct: 385 KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKF 444
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
I +L++++ + + + +TKL L+N+ K+ + + L + + L T+
Sbjct: 445 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTE 504
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
D + R+ E ES + + T E RD+ + ++
Sbjct: 505 VDALRLRLEEKESFLNKK--------------TKQLQDLTEEKGTLAGEIRDMKDMLEVK 550
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
+ R I+V+ ++ L+E+L ++L +LK+R K L + L +E A
Sbjct: 551 E---RKINVLQ-KKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEE--ALS 604
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+KE++ + LKEQ R + ER + + ++++ + ++ +
Sbjct: 605 EKERI-----IERLKEQ-RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 658
Query: 936 NKRLMKTIEELRYKKQD-LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
K ++ K+ LK+ +++ E+ +K + + + K +ED E +
Sbjct: 659 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDDSRMNPEFADQ 717
Query: 995 YKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNS 1054
K+LD+E A Y R+E K E LEI+ ++ N+K +K+I L + + +
Sbjct: 718 IKQLDKE----ASYY--RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHM 771
Query: 1055 TMYVATGSAIVQNQQITDVMKENQKL-KKMNAKLITICKKR 1094
QN+++ + +K NQ+L KK NA+L+ ++R
Sbjct: 772 KD---------QNKKVAN-LKHNQQLEKKKNAQLLEEVRRR 802
Score = 58.8 bits (136), Expect = 1e-07
Identities = 96/554 (17%), Positives = 227/554 (40%), Gaps = 33/554 (5%)
Query: 517 TLEEAHNEVKSLHEELTK--LYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
TL +K L E L L ++++N + ++ L++ + + E++ + L
Sbjct: 310 TLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHL 369
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
E+ ++ ++L K ++ + D E +LE Q++K NG + +
Sbjct: 370 REELHRRSQLQPEPAKTKALQTVIE-MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR 428
Query: 635 ADILMXXXXXXXXXXXXXXXXDEAKSLLEQN----LALKEQCEEKTRDCSRLEINIKTHE 690
+ + D+ K L + LAL+ + E + S + +I+ +
Sbjct: 429 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK 488
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
++ + + LQ ++ EKE+ LN+ T + + L + ++ ++ +
Sbjct: 489 ESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 548
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDENR 806
+ ++++ +I L+ +R + T ++ R
Sbjct: 549 VKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER 608
Query: 807 ---DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L E + DD + E LKE++ + Q EL + + +L + + A
Sbjct: 609 IIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLAS 668
Query: 864 YLQERDEQCARLKKEKLSLEQ---QVSNLKEQIRTQQPVERQAK----FADVAVNTDEDW 916
+RD ++LK ++++EQ + S L+ Q++ +E ++ FAD D++
Sbjct: 669 AGLKRD---SKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE- 724
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A+ + + AEV+ RL++ ++E+ +K D + +++ ++ K + A
Sbjct: 725 ASYYRDECGKA--QAEVD---RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 779
Query: 977 KRKELEDC-KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD-KLSN 1034
K + K + +L + + ++ +++L Q EE L++ + L+ +L++
Sbjct: 780 NLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-QIEELMNALEKTRQELDATKARLAS 838
Query: 1035 QKVALEKQIESLSN 1048
+ +L ++ L+N
Sbjct: 839 TQQSLAEKEAHLAN 852
Score = 58.0 bits (134), Expect = 2e-07
Identities = 149/745 (20%), Positives = 313/745 (42%), Gaps = 67/745 (8%)
Query: 46 KLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEGKYQNLILET 102
+++DS + + ++ + +E+ E+++K KL + IK S K + L E
Sbjct: 154 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEE 213
Query: 103 QTR-DLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTES 161
R +L Q++ EN I+ L D L+T+ + LQ+E+ N E+ T
Sbjct: 214 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQES---GNRGAEHFT-I 269
Query: 162 DNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDN 221
+ + L+ ++ ++ L K + E E +I + + E++ + L +
Sbjct: 270 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSK 328
Query: 222 TLSKLNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
L ++S+ D N TR +++ L+ LD ++ L E+ ++ L+ EP
Sbjct: 329 GLP--SKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR-RSQLQ-PEPA 384
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ---LINNESKKSKDHIDRYKDSLL 333
T L + E K K+ S ++RN+ L ++ L N ++D + K +
Sbjct: 385 KTKALQTVI------EMKDTKIAS-LERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 437
Query: 334 AVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
++F T +D + ++K + +L + K + ++C ++ + E L +
Sbjct: 438 YKSHSKFMKTKID----QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 493
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
+ + + LR+ R+ E S + KK +L++ LT+E L +I R
Sbjct: 494 KEQRAAILQTEVDALRL---RLEEKESFLN----KKTKQLQD-LTEE---KGTLAGEI-R 541
Query: 454 DLDQDLPA-HKKITILFDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXX 511
D+ L +KI +L + Q +L D ++ K R+ K++
Sbjct: 542 DMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRV-----KSLQTDSSNTDTAL 596
Query: 512 XXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKM 571
+ L E ++ L E+ + + +++E + K L E+++AL+ + + E +
Sbjct: 597 ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 656
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
+ L E + L GLK + + LKSL I ++KE + S+LE Q+ K + E D
Sbjct: 657 IDLKEHASSLASA-----GLKRD-SKLKSLEIAIEQKKE-ECSKLE--AQLKKAHNIEDD 707
Query: 632 -KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+M + +A++ +++ L + ++ E + D + +++
Sbjct: 708 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 767
Query: 691 -KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+ + QN+ + L+ Q + K K +L E + E D ++ +E A+
Sbjct: 768 LRHMKDQNKKVANLKHNQQLEKK----KNAQLLEEVRRREDSMADNSQHLQ-IEELMNAL 822
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQ 774
+ + D + R+A + + ++
Sbjct: 823 EKTRQELDATKARLASTQQSLAEKE 847
Score = 55.2 bits (127), Expect = 1e-06
Identities = 90/423 (21%), Positives = 194/423 (45%), Gaps = 46/423 (10%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSA-LEGKYQ 96
I+ + ++S + + K+ ++L +++ +E L E KEQ++A L+ +
Sbjct: 449 IDQLKQELSKKESELLALQTKL-ETLSNQNSDCKQHIEVLK-ESLTAKEQRAAILQTEVD 506
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDK-----EIKNLTDSLKTKSKKINELQEENDTLS 151
L L + ++ +++ K+ ++++LT++K EI+++ D L+ K +KIN LQ++ + L
Sbjct: 507 ALRLRLEEKESFLNK-KTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQ 565
Query: 152 NLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENL 211
+ + + NL V L+ ++ LE+ ++E E I +LKE
Sbjct: 566 EQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIE--------RLKEQR 617
Query: 212 IQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE 271
+ D + S N + K+ LQ+EL +L E +S+ +
Sbjct: 618 ERD-----DRERLEEIESFRKENKDLK-EKVNALQAELTEKESSLIDLKEHASSLAS-AG 670
Query: 272 LHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK-- 329
L + L+ + + E + K+ +++K+ N I ++S+ + + D+ K
Sbjct: 671 LKRDSKLKSLEIAIEQKKE---ECSKLEAQLKKAHN------IEDDSRMNPEFADQIKQL 721
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECT-SELKSVN 388
D + E G +V +L I+ + + +E +K K+ +L T +K N
Sbjct: 722 DKEASYYRDECGKAQAEVDRLL--EILKEVE---NEKNDKDKKI-AELESLTLRHMKDQN 775
Query: 389 EKLASL--NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSK 446
+K+A+L N QL +K+NA + +++ ++ + I + N L++ T++ L +K
Sbjct: 776 KKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEK--TRQELDATK 833
Query: 447 LKI 449
++
Sbjct: 834 ARL 836
Score = 54.4 bits (125), Expect = 2e-06
Identities = 139/703 (19%), Positives = 283/703 (40%), Gaps = 56/703 (7%)
Query: 43 NPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELF----DIKEQKSALEGKYQNL 98
N + Q+SG + +E+ + + ++ + ELF ++E + +E + Q L
Sbjct: 252 NHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL 311
Query: 99 ILETQT-RDLL-MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIME 156
++ + LL M Q K L ++L D E +++ + + ++ + + + E
Sbjct: 312 NARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLRE 371
Query: 157 NVTESDNLNKEVDDLKKNN---ECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ 213
+ L E K E K LE+ + + E++I ++ +
Sbjct: 372 ELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 431
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
I + SK ++ D K +SEL A + + L + K H+E+
Sbjct: 432 IKQIEVYKSHSKFMKTKIDQLKQELSKK----ESELLALQTKLETLSNQNSDCKQHIEVL 487
Query: 274 EPNMTMDLDEKLGENNEFETKAVKVMSEIKRN-LNSLSEQL--INNESKKSKDHIDRYKD 330
+ ++T E+ + E A+++ E K + LN ++QL + E I KD
Sbjct: 488 KESLTAK--EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 545
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEK 390
L E ++V + ++N+ + + D D+ L T ++ + ++ + +
Sbjct: 546 ML------EVKERKINVLQKKIENLQEQLR-DKDKQL---TNLKDRVKSLQTDSSNTDTA 595
Query: 391 LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKEN-ELKEILTKECLKLSKLKI 449
LA+L L EKE L+ Q+ER + I+ +KEN +LKE + +L++ +
Sbjct: 596 LATLEEALSEKERIIERLKEQRER-DDRERLEEIESFRKENKDLKEKVNALQAELTEKES 654
Query: 450 DIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXX 509
+ DL + + + D+ + E++ + E KL + A +
Sbjct: 655 SL-IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE 713
Query: 510 XXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEE 569
D +++ E +E K +++VD L ++K + E + IA+ E
Sbjct: 714 FA----DQIKQLDKEASYYRDECGKA-QAEVDR---LLEILKEVENEKNDKDKKIAELES 765
Query: 570 KMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITRE----KETQASELERSCQVIKQ 625
L + NK + L+++ N+ + L +V RE +Q ++E +++
Sbjct: 766 LTLRHMKDQNKKVANLKHNQQLEKKKNA-QLLEEVRRREDSMADNSQHLQIEELMNALEK 824
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQC-----EEKTRDCS 680
ELD KA + E + LE+ L +K++ EK + +
Sbjct: 825 TRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIA 884
Query: 681 RLEINIKTHEKTAE-------IQNRMIMRLQKQIQEDDKLFIE 716
LE++ +KT E ++R++ +L++Q Q KL +
Sbjct: 885 LLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 927
Score = 49.2 bits (112), Expect = 8e-05
Identities = 161/800 (20%), Positives = 314/800 (39%), Gaps = 92/800 (11%)
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQS-ELDAGREDCKELCEDFTSIKNHLEL-HEPNM 277
+N L + I DS + N I T S EL R KE + +K + + HE N
Sbjct: 173 ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQ 232
Query: 278 TMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHID-RYKDSLLAVL 336
+ L +A++ +R+LN L +Q N + +H + L
Sbjct: 233 HLQLT----------IQALQDELRTQRDLNHLLQQESGN---RGAEHFTIELTEENFRRL 279
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS--L 394
AE + ++F L+ + + ++ ++ +K T LN +K + E L S L
Sbjct: 280 QAEHDRQAKELF--LLRKTLEEMELRIET--QKQT-----LNARDESIKKLLEMLQSKGL 330
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVT-IDIVKKENELKEI-LTKECLKLSKLKIDIP 452
S+ +E +N + R+ E S V+ ++++ + E + I L +E + S+L+ +
Sbjct: 331 PSKSLEDDNE------RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 384
Query: 453 RDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR----LETGTAKAVXXXXXXXX 508
+ A + + + D I E + D E E + L+ L T +
Sbjct: 385 KT-----KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYK 439
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+++ E+ EL L +N N + + I+ LK ++ E
Sbjct: 440 SHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC----KQHIEVLKESLTAKE 495
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
++ L + + L + N K L D +T EK T A E+ ++
Sbjct: 496 QRAAILQTEVDALRLRLEEKESFL--NKKTKQLQD-LTEEKGTLAGEIRDMKDML----- 547
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E+ + K ++L D+ K L LK++ + D S + + T
Sbjct: 548 EVKERKINVLQKKIENLQEQLR-----DKDKQLTN----LKDRVKSLQTDSSNTDTALAT 598
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIE------KETK-LNELTNKYEALKRDYDAAVKD 741
E+ + R+I RL++Q + DD+ +E KE K L E N +A + ++++ D
Sbjct: 599 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 658
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L+ ++ ++D ++ LE I ++ F
Sbjct: 659 LKEHASSLASAGLKRD---SKLKSLEIAIE-QKKEECSKLEAQLKKAHNIEDDSRMNPEF 714
Query: 802 GDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETC 861
D+ + L + + S R + +EV +L E L + E +D ++ EL+
Sbjct: 715 ADQIKQLDK----EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELE---SLT 767
Query: 862 AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHS 921
++++++++ A LK + +++ + L E++R R+ AD + + + +++
Sbjct: 768 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVR-----RREDSMADNSQHLQIE-ELMNA 821
Query: 922 VVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+ R DA RL T + L K+ L N + +K +E+ + +E
Sbjct: 822 LEKTRQELDA---TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISE 878
Query: 982 EDCKAELEELKQRYKELDEE 1001
+D L EL K+ +E
Sbjct: 879 KDANIALLELSASKKKKTQE 898
Score = 37.1 bits (82), Expect = 0.35
Identities = 71/326 (21%), Positives = 134/326 (41%), Gaps = 32/326 (9%)
Query: 27 LDGAKSKNDNIIETQSNPIKLQDSGT---ITISCKMCQSLKESSNEINLKLEKLSGELFD 83
L+ A S+ + IIE + D I K + LKE N + +L + L D
Sbjct: 599 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 658
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINEL 143
+KE S+L RD S++KSLE+ K +E L LK K+ I +
Sbjct: 659 LKEHASSLAS-------AGLKRD---SKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDD 707
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
N ++ I + E+ E + + L + ++E N+ + KI
Sbjct: 708 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 767
Query: 204 QCKLKENLIQSLHIGYDNTLSK---------LNRSISDSNTSTRYNKICTLQSELDAGRE 254
+K+ + ++ ++ L K + R ++++ +I L + L+ R+
Sbjct: 768 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQ 827
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKA-VKVMSEIKRNLNSLS 310
+ S + L E H N+ ++ ++L E E + +A + +SE N+ L
Sbjct: 828 ELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALL- 886
Query: 311 EQLINNESKKSKDHI---DRYKDSLL 333
+L ++ KK+++ + R KD L+
Sbjct: 887 -ELSASKKKKTQEEVMALKREKDRLV 911
>U53445-1|AAA98972.1| 752|Homo sapiens DOC1 protein.
Length = 752
Score = 62.1 bits (144), Expect = 1e-08
Identities = 82/360 (22%), Positives = 159/360 (44%), Gaps = 35/360 (9%)
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDY 735
+ +E IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++
Sbjct: 130 AEVEELIKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQEC 187
Query: 736 DAAVKDLESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXX 794
+ +LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 188 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKL 239
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K
Sbjct: 240 KTLTVMFVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSK 296
Query: 855 DDECETCAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVN 911
D E +ERD+ +LK E+ L +V+ LK ++++ + +E+ + +
Sbjct: 297 TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQD 356
Query: 912 TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKD 971
+ + LH E K K L + +E L+ K +D+K + K ++Y +
Sbjct: 357 SGKSTTALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 406
Query: 972 KEFEAKRKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
+ + +R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 407 RRYANERDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 465
Score = 51.6 bits (118), Expect = 2e-05
Identities = 102/532 (19%), Positives = 215/532 (40%), Gaps = 53/532 (9%)
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+N + K+ ++ + + L ++ + + + L + +N + +
Sbjct: 25 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 84
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSL--DVFEI 350
K ++ + R ++ L E N +K+++ + K+ + E+G + +V E+
Sbjct: 85 QK----LAALSRQIDELEET--NRSLRKAEEELQDIKEK---ISKGEYGNAGIMAEVEEL 135
Query: 351 LMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRI 410
+ + + DL++ LE+ T D +L L L + + C L+
Sbjct: 136 IK---MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 192
Query: 411 QKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILF- 469
E+ + ++ ++ + +KE+ E +L K + L +DL K +T++F
Sbjct: 193 NLEKERMTTKQLSQELESLKVRIKELEAIES-RLEKTEFT----LKEDLTKLKTLTVMFV 247
Query: 470 DALITQYE-LSRTDYEIE--KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK 526
D T E L +T+ +++ +L++E V +EE V
Sbjct: 248 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 307
Query: 527 SLHEELTKLYKSKVDENN---ANLNLIKILSEEIDALKIAIAKNE------EKMLSLSEK 577
++L K++ ++ N + +N++K + ++A++ KN+ + +L ++
Sbjct: 308 KERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQE 367
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
+NK+ EL + LK + +K++ D + + E + LER + ++ KA
Sbjct: 368 NNKIKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLERR--------YANERDKAQF 418
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE-KTRDCSRL--EINIKTHEKTAE 694
L ++ ++ EQ L + Q EE K+ SR + K HE A
Sbjct: 419 LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 478
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
+I LQ D +K KLN+ N+ L R+ + K+LE R
Sbjct: 479 --EDLICHLQ-----GDHSVCKK--KLNQQENRNRDLGREIENLTKELERYR 521
>AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens cDNA
FLJ43937 fis, clone TESTI4013924. ).
Length = 623
Score = 62.1 bits (144), Expect = 1e-08
Identities = 97/474 (20%), Positives = 204/474 (43%), Gaps = 42/474 (8%)
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK--QNGF- 628
L+ S ++L E+ + +E L S + +TRE E + + +K QN F
Sbjct: 8 LNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFD 67
Query: 629 --ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI 686
E ++ AD+ + + S L+Q+ ALKE+ E++ D + +
Sbjct: 68 TCEAERKHADLQISELTRHAEDATKQA--ERYLSELQQSEALKEEAEKRRED-----LKL 120
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSR 746
K E + + + +L++ +++ + E K N++ + + LK AA++ +E+ R
Sbjct: 121 KAQESIRQWKLKH-KKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLR 179
Query: 747 EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENR 806
+ +N + T++ L E + E +R ++ T
Sbjct: 180 KELNDVLTKRALQEEELHSKEEKLRDIKS----------HQADLELEVKNSLDTIHRLES 229
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
+L + K+ K + + + E+++LK+ + +L +++E K+L A L
Sbjct: 230 ELKKQSKIQSQMKVEKAHLEE-EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLA 288
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQ---IRTQQPVER---QAKFADV-----AVNTDED 915
E + + K+ L Q + E+ I TQ +ER Q + D+ +V T +
Sbjct: 289 EEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHE 348
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMK--TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
N+ ++ +E E + R +K ++EE K + + K++ ++ T++ +
Sbjct: 349 -QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIH-RGQLEKLKSQCDRLTEELTQ 406
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
E + K+L K + + LK + +E ++ E+L++ EE +LK+ + LE
Sbjct: 407 NENENKKL---KLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLE 457
Score = 50.4 bits (115), Expect = 3e-05
Identities = 79/388 (20%), Positives = 172/388 (44%), Gaps = 55/388 (14%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + + E+ EL + K E + ++L L+ Q I+ ++++
Sbjct: 83 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQ------ESIRQWKLKHKKL 136
Query: 123 DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKC 182
++ ++ ++++ + K N++ +E D L + + + +NL KE++D+ LT++
Sbjct: 137 ERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDV------LTKRA 190
Query: 183 IDLEKLVNESENKIGPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTSTRY-- 239
+ E+L ++ E K+ A +L+ +N + ++H ++ L K ++ S +
Sbjct: 191 LQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIH-RLESELKKQSKIQSQMKVEKAHLE 249
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM 299
+I L+ + +D +L E SIK+ + DL KL E + +K +
Sbjct: 250 EEIAELKK---SQAQDKAKLLEMQESIKDLSAIR-----ADLANKLAEEERAKKAVLKDL 301
Query: 300 SEIKRNLNSLSEQ--LINNESKKSKD-HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNII 356
S++ S E+ I + K +D H KD T+SL ++
Sbjct: 302 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDL----------TSSL-------QSVK 344
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH 416
K++ ++ E+++ + K E + +L ++ +E++N I R Q E++
Sbjct: 345 TKHEQNIQELMKHFKK----------EKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLK 394
Query: 417 EISSAVTIDIVKKENELKEILTK-ECLK 443
+T ++ + ENE K++ K +CLK
Sbjct: 395 SQCDRLTEELTQNENENKKLKLKYQCLK 422
Score = 47.6 bits (108), Expect = 2e-04
Identities = 47/233 (20%), Positives = 106/233 (45%), Gaps = 16/233 (6%)
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
S+V L L + +++ + +R KE+ + +TC + D Q + L + +Q
Sbjct: 36 SQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAE 95
Query: 888 NLKEQIRTQQPVERQA--KFADVAVNTDE---DWANLHSVV---VDRMS--YDAEVEKNK 937
+++ + ++ +A + D+ + E W H + +++ S D KN
Sbjct: 96 RYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNN 155
Query: 938 RLMKTIEELRYK----KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQ 993
+++K +EL+ + Q ++N ++ + K +++E +K ++L D K+ +L+
Sbjct: 156 QILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLEL 215
Query: 994 RYK-ELDEECETCAEYLKQREEQCK-RLKEAKIALEIVDKLSNQKVALEKQIE 1044
K LD +E KQ + Q + ++++A + EI + +Q K +E
Sbjct: 216 EVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLE 268
Score = 42.3 bits (95), Expect = 0.009
Identities = 48/265 (18%), Positives = 120/265 (45%), Gaps = 19/265 (7%)
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQ 884
+ + E+ +E+L + DL+ K D L+++ + +++K EK LE+
Sbjct: 191 LQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEE 250
Query: 885 QVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR-LMKTI 943
+++ LK + + +AK ++ E +L ++ D + AE E+ K+ ++K +
Sbjct: 251 EIAELK-----KSQAQDKAKLLEM----QESIKDLSAIRADLANKLAEEERAKKAVLKDL 301
Query: 944 EEL----RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE-DCKAELEELKQRYKEL 998
+L + + ++ +T+++ + + ++ K+ + + ++ + ++EL + +K+
Sbjct: 302 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE 361
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYV 1058
E E LK + K + AKI ++KL +Q L +++ N Y
Sbjct: 362 KSEAENHIRTLKAESLEEKNM--AKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQ 419
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKM 1083
+ + ++ + E + L++M
Sbjct: 420 CLKDQLEEREKHISI--EEEHLRRM 442
Score = 41.9 bits (94), Expect = 0.012
Identities = 79/467 (16%), Positives = 185/467 (39%), Gaps = 42/467 (8%)
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
L EKD T+L + L++ N K LNDV+T+ + Q EL + ++ ++
Sbjct: 158 LKEKDELKTQLYAA---LQQIENLRKELNDVLTK-RALQEEELHSKEEKLR----DIKSH 209
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
+AD+ + + + Q K EE+ + + + K
Sbjct: 210 QADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAK---- 265
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA----V 749
++ +Q+ I++ + + KL E +A+ +D +S E +
Sbjct: 266 ------LLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATII 319
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
QL ++D+ + + +L S +++ +T + R L
Sbjct: 320 TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAE------NHIRTL- 372
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
K + +++++ I ++ +LK + +EL + K+L + + + L+ER+
Sbjct: 373 ---KAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEERE 429
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ + ++ +E+ LK+Q+ + E+++ + D V+++
Sbjct: 430 KHISIEEEHLRRMEEARLQLKDQLLCLE-TEQESILGVIGKEIDAACKTFSKDSVEKLKV 488
Query: 930 -----DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF----EAKRKE 980
D + ++ L ++ +L++ ++LK + + + ++ E K E
Sbjct: 489 FSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESE 548
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE 1027
L+ ++E +Q E+ E E ++++E+ L++ IALE
Sbjct: 549 LQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALE 595
Score = 41.5 bits (93), Expect = 0.016
Identities = 99/451 (21%), Positives = 192/451 (42%), Gaps = 37/451 (8%)
Query: 66 SSNEINLKLEKLSGELFDIKEQKSALEGKYQNLI--LETQTRDLLMSQIKSLEMENLTKD 123
S + L ++ EL ++K + + +L +E TR+L + + L+M L +
Sbjct: 2 SDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQM--LDRL 59
Query: 124 KEIKNLTDSLKTKSK----KINELQ---EENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
KEI+N D+ + + K +I+EL E+ + + + +S+ L +E + +++ +
Sbjct: 60 KEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLK 119
Query: 177 CLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD-SNT 235
Q+ I KL ++ + K +L Q L D ++L ++ N
Sbjct: 120 LKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILK-EKDELKTQLYAALQQIENL 178
Query: 236 STRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKA 295
N + T ++ + +E D S + LEL N ++D +L +E + K
Sbjct: 179 RKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKN-SLDTIHRL--ESELK-KQ 234
Query: 296 VKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDA--EFGTTSLDVFEILMD 353
K+ S++K L E++ + +++D K LL + ++ + D+ L +
Sbjct: 235 SKIQSQMKVEKAHLEEEIAELKKSQAQD-----KAKLLEMQESIKDLSAIRADLANKLAE 289
Query: 354 NIINKYQI--DLDEILEKYTKVQGDLNECTSELK---SVNEK-LASLNSQL--IEKENAC 405
K + DL ++ + + ++LK V+++ L L S L ++ ++
Sbjct: 290 EERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ 349
Query: 406 NILRIQKERIHEISSAVT-IDIVKKEN-ELKEILTKECLKLSKLKIDIPR---DLDQDLP 460
NI + K E S A I +K E+ E K + +L KLK R +L Q+
Sbjct: 350 NIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN 409
Query: 461 AHKKITILFDALITQYELSRTDYEIEKEKLR 491
+KK+ + + L Q E IE+E LR
Sbjct: 410 ENKKLKLKYQCLKDQLEEREKHISIEEEHLR 440
Score = 39.9 bits (89), Expect = 0.049
Identities = 92/543 (16%), Positives = 219/543 (40%), Gaps = 47/543 (8%)
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
+ + +A+L + ++ DA K A E+ LS ++ L E + E+ L
Sbjct: 70 EAERKHADLQISELTRHAEDATKQA-----ERYLSELQQSEALKEEAEK----RREDLKL 120
Query: 599 KSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEA 658
K+ + R+ + + +LER+ + + EL IL +
Sbjct: 121 KAQESI--RQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENL 178
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR----MIMRLQKQIQEDDKLF 714
+ L L + EE+ +IK+H+ E++ + I RL+ ++++ K+
Sbjct: 179 RKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQ 238
Query: 715 IEKETKLNELTNKYEALKR----------DYDAAVKDLESSR-EAVNQLTTQKDLVEGRI 763
+ + + L + LK+ + ++KDL + R + N+L ++ + +
Sbjct: 239 SQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL 298
Query: 764 AEL-----ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP 818
+L ++ R E+TAT+ + + +L
Sbjct: 299 KDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHF 358
Query: 819 KRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK-- 876
K+ S +++ + LK L + + + ++L +C+ E L + + + +LK
Sbjct: 359 KKEKSE-AENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLK 417
Query: 877 ----KEKL-SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD-EDWANLHSVVVDR--MS 928
K++L E+ +S +E +R + Q K + + T+ E + +D +
Sbjct: 418 YQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKT 477
Query: 929 YDAEVEKNKRLMKTIEELRYKKQD-LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
+ + + ++ + ++ Y L + TK+Q E+ +++ + R +L C+ +
Sbjct: 478 FSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQ 537
Query: 988 LEELKQRYKELDEECETCAEYLKQREEQCKRL-KEAKIALEIVDKLSNQKVALEKQIESL 1046
L L + KE + +C + ++++E+ + +E + LE + + +L+ ++ +L
Sbjct: 538 LRNLTEN-KESELQC--LFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIAL 594
Query: 1047 SNT 1049
+
Sbjct: 595 ETS 597
>AF273054-1|AAM44457.1| 613|Homo sapiens CTCL tumor antigen HD-CL-01
protein.
Length = 613
Score = 62.1 bits (144), Expect = 1e-08
Identities = 99/512 (19%), Positives = 215/512 (41%), Gaps = 37/512 (7%)
Query: 569 EKMLSLSEK--DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQN 626
E L L EK +K + I L +EN + L I EK+ EL++ + KQ+
Sbjct: 5 EHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQH 64
Query: 627 GFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ---NLALK-----EQCEEKTRD 678
+ ++++ I AK+ ++Q +A + ++CEE ++
Sbjct: 65 MNTIKQLESRIEELNKEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQE 124
Query: 679 CSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK-------YEAL 731
+ + EK + + L+K++++ +K + K+ +L+ + YE
Sbjct: 125 KEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 184
Query: 732 KRDYDAAVKDLESSREAVNQLTTQKDLVEGRI-AELESDIRTE---QTATVXXXXXXXXX 787
+ + +++++ +E +N + + ++ AE++S T+ + T
Sbjct: 185 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEA 244
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELD 845
T+ E+ ++ N +LD + + + E S E + +EL+
Sbjct: 245 DQIRKNCQDMIKTY-QESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELE 302
Query: 846 DLKERYKELDDECET------CAEYLQERDEQCARLKKEKLSLEQ-QVSNLKEQIRTQQP 898
DLK +KE DE T C E + R E KE ++ ++ ++ NL ++++T
Sbjct: 303 DLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQ 362
Query: 899 VERQAKFADVAV-NTDEDWANLHSVVVD-RMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
++ Q + + N E+ +L+S++ D + + ++ L+ E L K L++
Sbjct: 363 LQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 422
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL-DEECETCAEYLKQREEQ 1015
+Q +K + + + +++ ++++ LE + +EL EE +T L R+ +
Sbjct: 423 SNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTE 482
Query: 1016 CKRLKEAKIALEIVDKLSNQKVALEKQIESLS 1047
K L E+ D+L Q+ I+ L+
Sbjct: 483 VKALSTQ--VEELKDELVTQRRKHASSIKDLT 512
Score = 51.2 bits (117), Expect = 2e-05
Identities = 96/504 (19%), Positives = 207/504 (41%), Gaps = 38/504 (7%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS-EK 577
+E ++ S + L + K + + ++N IK L I+ L + + +K+++
Sbjct: 37 QELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDKLIAQDVTA 96
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
N + +L + E+ N K + +EKE + R ++ +L K K +
Sbjct: 97 KNAVQQLHKEMAQRMEQAN--KKCEEA-RQEKEAMVMKYVRG----EKESLDLRKEKETL 149
Query: 638 ---LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE-QCEEKTRDCSRLEINIKTHE-KT 692
L + K L Q KE + R+ +L+ +I +H K
Sbjct: 150 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 209
Query: 693 AEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV-NQ 751
QN++ + + DKL E TKL + + + ++++ +K + S E N+
Sbjct: 210 KWAQNKLKAEMDSHKETKDKLK-ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNE 268
Query: 752 LTTQKDLVEGRIAEL---ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT----FGDE 804
L + + +G + + +SD A + T DE
Sbjct: 269 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE 328
Query: 805 NR----DLGENPKLDDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDEC 858
+L + ++ + K I + D QL+E+L +QE+++LKE + L+
Sbjct: 329 RLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLN--- 385
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ LQ+ E + + E L +++++ Q++++ Q++F V+ + + +
Sbjct: 386 -SLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESN-SLQSQFDKVSCSESQLQSQ 443
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTK--KDKEFEA 976
+ ++ ++ + K + L K EE++ + +L T++ KA+ + KD+
Sbjct: 444 CEQMKQTNINLESRLLKEEELRK--EEVQTLQAELACRQTEV-KALSTQVEELKDELVTQ 500
Query: 977 KRKELEDCKAELEELKQRYKELDE 1000
+RK K ++L+Q ++LD+
Sbjct: 501 RRKHASSIKDLTKQLQQARRKLDQ 524
Score = 50.8 bits (116), Expect = 3e-05
Identities = 110/549 (20%), Positives = 229/549 (41%), Gaps = 48/549 (8%)
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
K + D + I +L +EN L ++ +E DNL +E LKK E Q ++
Sbjct: 13 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQHMNTIK 69
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+L E++I N + K + + + + N + +L++ + + + NK C
Sbjct: 70 QL----ESRIEELN--KEVKASRDKLIAQDVTAKNAVQQLHKEM--AQRMEQANKKCE-- 119
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGE-NNEFE--TKAVKVMSEIK 303
+A +E + + K L+L + T L++KL + N E E T +K +S+ K
Sbjct: 120 ---EARQEKEAMVMKYVRGEKESLDLRKEKET--LEKKLRDANKELEKNTNKIKQLSQEK 174
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLA-VLDAEFGTTSLDVFEILMDNIINKYQID 362
L+ L E E+ + ID+ K+ + + V+ ++ L + MD+ ++
Sbjct: 175 GRLHQLYETK-EGETTRLIREIDKLKEDINSHVIKVKWAQNKL---KAEMDS----HKET 226
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNI-LRIQKERIHEISSA 421
D++ E TK+ E K+ + + + K N + LR+ K + +
Sbjct: 227 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK---- 282
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD-ALITQYELSR 480
+ +K ++L E+ + +L LK +D+ K+ L D L T+ ELS+
Sbjct: 283 ---QMQEKSDQL-EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 338
Query: 481 TDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKV 540
I ++K ++ K +E EV+SL+ + L K +
Sbjct: 339 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK--QEIENLKEEVESLNSLINDLQKD-I 395
Query: 541 DENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDN-KLTELVSTINGLKEENNSLK 599
+ + + + + +E + + + + S +K + ++L S +K+ N +L+
Sbjct: 396 EGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE 455
Query: 600 S--LNDVITREKETQASELERSCQ--VIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
S L + R++E Q + E +C+ +K +++++K +++
Sbjct: 456 SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQL 515
Query: 656 DEAKSLLEQ 664
+A+ L+Q
Sbjct: 516 QQARRKLDQ 524
Score = 47.2 bits (107), Expect = 3e-04
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 19/229 (8%)
Query: 820 RSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEK 879
+ + D ++Q + QQ ++ +R ++ + +CE + + + R +KE
Sbjct: 80 KEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 139
Query: 880 LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL 939
L L ++ L++++R + K + ++ LH + Y+ + + RL
Sbjct: 140 LDLRKEKETLEKKLRDAN--KELEKNTNKIKQLSQEKGRLHQL------YETKEGETTRL 191
Query: 940 MKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
++ I++L K+D+ + V K++ A K E ++ ++ + K +L Q +E D
Sbjct: 192 IREIDKL---KEDINSHVIKVKWAQNKL---KAEMDSHKETKDKLKETTTKLTQAKEEAD 245
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSN 1048
+ + C + +K +E +E K + E+ KL K LEKQ++ S+
Sbjct: 246 QIRKNCQDMIKTYQES----EEIK-SNELDAKLRVTKGELEKQMQEKSD 289
Score = 46.0 bits (104), Expect = 8e-04
Identities = 66/335 (19%), Positives = 148/335 (44%), Gaps = 27/335 (8%)
Query: 86 EQKSALEGKYQNLILETQTR-DLLMSQIKSLEMENLTKDKEIKNLTDSL-KTKSKKINEL 143
++++ E ++ N I + ++R + L ++K+ + + +D KN L K ++++ +
Sbjct: 55 KKRTETEKQHMNTIKQLESRIEELNKEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQA 114
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICA 203
++ + V + KE DL+K E L +K D K + ++ NKI K +
Sbjct: 115 NKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKI--KQLSQ 172
Query: 204 QCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC--TLQSELDAGRE---DCKE 258
+ L ++ + ++++ D N+ K L++E+D+ +E KE
Sbjct: 173 EKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE 232
Query: 259 LCEDFTSIKNHLELHEPN-----MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQL 313
T K + N T E++ ++NE + K E+++ + S+QL
Sbjct: 233 TTTKLTQAKEEADQIRKNCQDMIKTYQESEEI-KSNELDAKLRVTKGELEKQMQEKSDQL 291
Query: 314 INNESK-KSKDHIDR-YKDSLLAVLDAEFGTTSLDVFEILMDN-------IINKYQIDLD 364
+ +K K + + R +K+ + + L+ + ++ IIN+ + ++
Sbjct: 292 EMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQ 351
Query: 365 EILEKY---TKVQGDLNECTSELKSVNEKLASLNS 396
+L+K ++Q L E++++ E++ SLNS
Sbjct: 352 NLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS 386
Score = 41.9 bits (94), Expect = 0.012
Identities = 71/347 (20%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEME---NLT 121
+S E KL++ + +L KE+ + Q++I Q + +IKS E++ +T
Sbjct: 221 DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESE----EIKSNELDAKLRVT 276
Query: 122 K---DKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECL 178
K +K+++ +D L+ KI EL++ L E + E L +V L+
Sbjct: 277 KGELEKQMQEKSDQLEMHHAKIKELED----LKRTFKEGMDELRTLRTKVKCLEDERLRT 332
Query: 179 TQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
+ ++++N + +I +N+ + K + L + L G + L + N+
Sbjct: 333 EDELSKYKEIINRQKAEI--QNLLDKVKTADQLQEQLQRGKQE-IENLKEEVESLNSL-- 387
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
I LQ +++ R+ EL L +T + E+N +++ KV
Sbjct: 388 ---INDLQKDIEGSRKRESELL-----------LFTERLTSKNAQLQSESNSLQSQFDKV 433
Query: 299 M---SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNI 355
S+++ + + IN ES+ K+ R ++ + L AE +V +
Sbjct: 434 SCSESQLQSQCEQMKQTNINLESRLLKEEELRKEE--VQTLQAELACRQTEVKALSTQ-- 489
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKE 402
+ + + DE++ + K + + T +L+ KL + S +KE
Sbjct: 490 VEELK---DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 533
Score = 41.5 bits (93), Expect = 0.016
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 48/286 (16%)
Query: 26 QLDGAKSKNDNIIETQSNPIKL-QDSGTITISCK-MCQSLKES----SNEINLKLEKLSG 79
++D K D + ET + + +++ I +C+ M ++ +ES SNE++ KL G
Sbjct: 219 EMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKG 278
Query: 80 ELFDIKEQKS-ALEGKYQNLI-LETQTRDL---------LMSQIKSLEMENL-TKDK--- 124
EL ++KS LE + + LE R L +++K LE E L T+D+
Sbjct: 279 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 338
Query: 125 ----------EIKNLTDSLKTK----------SKKINELQEENDTLSNLIMENVTESDNL 164
EI+NL D +KT ++I L+EE ++L++LI + + +
Sbjct: 339 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS 398
Query: 165 NKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLS 224
K +L E LT K L+ N +++ K C++ +L+ Q N S
Sbjct: 399 RKRESELLLFTERLTSKNAQLQSESNSLQSQF-DKVSCSESQLQSQCEQMKQTNI-NLES 456
Query: 225 KLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+L + R ++ TLQ+EL + + K L +K+ L
Sbjct: 457 RLLK-----EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL 497
Score = 35.9 bits (79), Expect = 0.80
Identities = 86/423 (20%), Positives = 173/423 (40%), Gaps = 45/423 (10%)
Query: 58 KMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQ--NLILETQTRDLL-MSQIKS 114
K C+ ++ + +K + E D++++K LE K + N LE T + +SQ K
Sbjct: 116 KKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKG 175
Query: 115 -LEMENLTKD-------KEIKNLTDSLKTKSKKI----NELQEENDT---LSNLIMENVT 159
L TK+ +EI L + + + K+ N+L+ E D+ + + E T
Sbjct: 176 RLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTT 235
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE----NKIGPKNICAQCKLKENLIQ-- 213
+ +E D ++KN C D+ K ESE N++ K + +L++ + +
Sbjct: 236 KLTQAKEEADQIRKN-------CQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKS 288
Query: 214 ---SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL 270
+H L L R+ + R + T L+ R ++ + I N
Sbjct: 289 DQLEMHHAKIKELEDLKRTFKEGMDELR--TLRTKVKCLEDERLRTEDELSKYKEIINRQ 346
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD 330
+ N+ +D + + E + + + +K + SL+ LIN+ K + R +
Sbjct: 347 KAEIQNL-LDKVKTADQLQEQLQRGKQEIENLKEEVESLN-SLINDLQKDIEGSRKRESE 404
Query: 331 SLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV-QGDLNECTSELKSVNE 389
LL L + + +K ++ + ++ Q ++N + LK E
Sbjct: 405 LLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK--EE 462
Query: 390 KLASLNSQLIEKENACNILRIQ--KERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
+L Q ++ E AC ++ ++ E+ + K + +K+ LTK+ L+ ++
Sbjct: 463 ELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKD-LTKQ-LQQARR 520
Query: 448 KID 450
K+D
Sbjct: 521 KLD 523
Score = 35.1 bits (77), Expect = 1.4
Identities = 93/430 (21%), Positives = 174/430 (40%), Gaps = 50/430 (11%)
Query: 372 KVQGDLNECTSELKSVNEKLASLNS------QLIEKENACNILRIQK--ERIHEISSAVT 423
+++ + E E+K+ +KL + + Q + KE A + + K E + A+
Sbjct: 70 QLESRIEELNKEVKASRDKLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMV 129
Query: 424 IDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYEL----- 478
+ V+ E E + L KE L K D ++L+++ K+++ L YE
Sbjct: 130 MKYVRGEKESLD-LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGET 188
Query: 479 SRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLY 536
+R EI+K K + + K D L+E ++ EE ++
Sbjct: 189 TRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIR 248
Query: 537 KSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENN 596
K+ D +I S E+DA K+ + K E + + EK ++L + I L++
Sbjct: 249 KNCQDMIKTYQESEEIKSNELDA-KLRVTKGELEK-QMQEKSDQLEMHHAKIKELEDLKR 306
Query: 597 SLKS-LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXX 655
+ K ++++ T + + E ER + EL K K I
Sbjct: 307 TFKEGMDELRTLRTKVKCLEDERL-----RTEDELSKYKEIINRQKA------------- 348
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDK--- 712
E ++LL++ + E+ R +E N+K + E N +I LQK I+ K
Sbjct: 349 -EIQNLLDKVKTADQLQEQLQRGKQEIE-NLK---EEVESLNSLINDLQKDIEGSRKRES 403
Query: 713 ---LFIEKETKLN-ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELES 768
LF E+ T N +L ++ +L+ +D + Q+ +E R+ + E
Sbjct: 404 ELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK-EE 462
Query: 769 DIRTEQTATV 778
++R E+ T+
Sbjct: 463 ELRKEEVQTL 472
>Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50
protein.
Length = 1318
Score = 61.7 bits (143), Expect = 1e-08
Identities = 163/865 (18%), Positives = 341/865 (39%), Gaps = 80/865 (9%)
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT--MDLDEKLG----------- 286
++I + +++L + +E K + +KN L+ E N++ M LD ++
Sbjct: 231 DQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEK 290
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+N+E E K KV LN L +K + +D +++ L L+ E + +
Sbjct: 291 DNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQE 348
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
E+L++ + Q+ D E + ++L+ + + + I+ N
Sbjct: 349 KSELLVEQ--GRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIK--NFHK 404
Query: 407 ILRIQKERIHEISSAVTIDIVKKEN----ELKEILTKECL--KLSKLKIDIPRDLDQDLP 460
++R ++E + ++ + D +KE ++ EI K+ ++ +LK +I +L
Sbjct: 405 LVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELK 464
Query: 461 AHK-KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD-TL 518
K ++ L + EL + + E+E + E + D TL
Sbjct: 465 NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTL 524
Query: 519 EEAHNEVKSLHEELTK------LYKSKVDENNANLNLIKILSEEIDALKIAIAKN---EE 569
+ E++ L+ T L K K D++ + S+E+ +L E+
Sbjct: 525 RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 584
Query: 570 KMLSLSEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ S S++ N+ + ++ +N L + +N+ + R++E +S ++ V F
Sbjct: 585 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELERKEEQLSSYEDKLFDVCGSQDF 644
Query: 629 E--LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI 686
E LD++K +I L ++N + C+ + + L+ I
Sbjct: 645 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEAI 704
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIE--------------KETKLNELTNKYEALK 732
+ + + + ++++ +K E KE ++ EL NK + +
Sbjct: 705 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPMRQSIIDLKEKEIPELRNKLQNVN 764
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
RD D+E + + +++ ++ + I +
Sbjct: 765 RDIQRLKNDIEEQETLLGTIMPEEE--SAKVCLTDVTIMERFQMELKDVERKIAQQAAKL 822
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQE-LDDLKERY 851
T N++ E D+ I +L +L+ QQE + LK
Sbjct: 823 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKI---------ELNRKLIQDQQEQIQHLKSTT 873
Query: 852 KELDDECETCAEYLQER---DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFAD 907
EL E + LQ R +EQ L E SL +++ + KEQ+ P+E KF
Sbjct: 874 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQV---SPLETTLEKFQQ 930
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIE-ELRYKKQD-LKNTVTKMQKAM 964
+ + D+++ E KN MK IE ++ K D +K T++ K +
Sbjct: 931 EKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENHIQDGKDDYMKQKETELNKVI 990
Query: 965 EKYTKKDKEFEAKRKELEDCKAEL--EELKQRYKELDEECETCAEYLKQREEQCKR-LKE 1021
+ ++ +K E +++ + ++ +++++R+ + + E LK+ EE+ K+ LKE
Sbjct: 991 AQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEEGKQHLKE 1050
Query: 1022 AKIALEIVDKLSNQKVALEKQIESL 1046
+ K +QK LE+ I+++
Sbjct: 1051 MGQMQVLQMKSEHQK--LEENIDNI 1073
Score = 52.8 bits (121), Expect = 7e-06
Identities = 81/472 (17%), Positives = 191/472 (40%), Gaps = 39/472 (8%)
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
E+ SK + ++ ++K E+D LK + + E + + + DN++ L S
Sbjct: 228 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 287
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
++++N+ L+ + + + + Q ++L + Q + E ++ D
Sbjct: 288 MEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ---RTVREKERKLVDC------------- 331
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
E + L +++ L ++ E + RL++ H++ ++ +I L Q++ D
Sbjct: 332 ----HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELD 387
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL-ESD 769
F ++ N ++ ++ + K ++ + +N ++ L + +I E+ +
Sbjct: 388 G--FERGPFSERQIKNFHKLVRERQEGEAK---TANQLMNDFAEKETLKQKQIDEIRDKK 442
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ + G +R L + +L + + +S
Sbjct: 443 TGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSN 502
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
V LK ++S Q E DL ++LD E E + R Q L K+K ++Q+ +
Sbjct: 503 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR-TQMEMLTKDKADKDEQIRKI 561
Query: 890 KEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + + + F + EDW + S +++ + D + NK L +
Sbjct: 562 KSR-HSDELTSLLGYFPN--KKQLEDWLHSKSKEINQ-TRDRLAKLNKELASS----EQN 613
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
K + N + + ++ + Y +DK F+ +D +++L+ LK+ ++ ++
Sbjct: 614 KNHINNELERKEEQLSSY--EDKLFDVCGS--QDFESDLDRLKEEIEKSSKQ 661
Score = 49.2 bits (112), Expect = 8e-05
Identities = 137/718 (19%), Positives = 303/718 (42%), Gaps = 72/718 (10%)
Query: 101 ETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTE 160
E +T + LM+ E E L K K+I + D KT +I EL+ E ++ + E
Sbjct: 413 EAKTANQLMNDFA--EKETL-KQKQIDEIRDK-KTGLGRIIELKSE------ILSKKQNE 462
Query: 161 SDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQC-KLKENLIQSLHIGY 219
N+ E+ L+ +++ + + +D E + E E KN + K++ +Q+
Sbjct: 463 LKNVKYELQQLEGSSDRILE--LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 520
Query: 220 DNTLSKLNRSISDSN--TSTRYNKICTLQSELDAGREDCK---ELCEDFTSIKNHLELHE 274
D TL KL++ + N T+TR + + D + K ++ TS+ + ++
Sbjct: 521 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFP-NK 579
Query: 275 PNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
+ L K E N+ + K+ E+ + + + INNE ++ ++ + Y+D L
Sbjct: 580 KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNH--INNELERKEEQLSSYEDKLFD 637
Query: 335 VLDAEFGTTSLDVFEILMDN-------------IINKYQIDL-DE------ILEKYTKVQ 374
V ++ + LD + ++ + +++ L DE + ++ + +
Sbjct: 638 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE 697
Query: 375 GDLNECTSELKS----VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+L E S+L+S +KL S S+L +KE R + + + ++ ID+ +KE
Sbjct: 698 AELQEAISDLQSKLRLAPDKLKSTESELKKKEKR----RDEMLGLAPMRQSI-IDLKEKE 752
Query: 431 -NELKEILTKECLKLSKLKIDIPRD---LDQDLPAHKKITI-LFDALITQYELSRTDYEI 485
EL+ L + +LK DI L +P + + L D I + R E+
Sbjct: 753 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTI----MERFQMEL 808
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ + ++ AK +E +++ ++ ++ +L + + +
Sbjct: 809 KDVERKIAQQAAKLQGIDLDRTVQQVN---QEKQEKQHKLDTVSSKI-ELNRKLIQDQQE 864
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS---TINGLKEENNSLKSL 601
+ +K + E+ + K+ I+ N ++ L E+ +L TE+ S I KE+ + L++
Sbjct: 865 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETT 924
Query: 602 NDVITREKETQASELERSCQVIKQNGFEL-DKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ +EKE ++ S ++ + ++ +K+K + ++
Sbjct: 925 LEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENHIQDGKDDYMKQKET 984
Query: 661 LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI---MRLQKQIQEDDKLFIEK 717
L + +A +CE+ + ++ T +IQ R + + L+K+ +E ++ E
Sbjct: 985 ELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEEG 1044
Query: 718 ETKLNELTN-KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQ 774
+ L E+ + +K ++ +++++ + N ++ E I + ++R Q
Sbjct: 1045 KQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQ 1102
Score = 42.3 bits (95), Expect = 0.009
Identities = 114/629 (18%), Positives = 270/629 (42%), Gaps = 52/629 (8%)
Query: 26 QLDGAKSK----NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL 81
QL+G+ + + +I+ + K + + + SL+ +++ L KL E+
Sbjct: 472 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 531
Query: 82 FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK----DKEIKNLTDSLKTKS 137
+ + + + L + +D + +IKS + LT K L D L +KS
Sbjct: 532 EQLNHHTTT-RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKS 590
Query: 138 KKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIG 197
K+IN+ + D L+ L E + N N ++L++ E L+ L + + +
Sbjct: 591 KEINQTR---DRLAKLNKELASSEQNKNHINNELERKEEQLSSYEDKLFDVCGSQDFESD 647
Query: 198 PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS--TRYNKICTLQSELDAGRED 255
+ + + K + +++ G S+ ++D N S ++ ++EL D
Sbjct: 648 LDRLKEEIE-KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEAISD 706
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN 315
+ E DE LG ++ EI N L Q +N
Sbjct: 707 LQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPMRQSIIDLKEKEIPELRNKL--QNVN 764
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE----ILEKYT 371
+ ++ K+ I+ +++LL + E + + + ++ I+ ++Q++L + I ++
Sbjct: 765 RDIQRLKNDIEE-QETLLGTIMPEEESAKVCLTDV---TIMERFQMELKDVERKIAQQAA 820
Query: 372 KVQG-DLNECTSEL-KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
K+QG DL+ ++ + EK L++ + E +++ Q+E+I + S T ++ +
Sbjct: 821 KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS-TTNELKSE 879
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
+ ++ L + +L + +++ ++ Q L +++I + ++ E + ++ EKE+
Sbjct: 880 KLQISTNLQRR-QQLEEQTVELSTEV-QSL--YREIKDAKEQ-VSPLETTLEKFQQEKEE 934
Query: 490 LRLETGTA-KAVXXXXXXXXXXXXXXFDTLEEAHNEVKS-----LHEELTKLYK-----S 538
L + T+ K +++ N ++ + ++ T+L K S
Sbjct: 935 LINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENHIQDGKDDYMKQKETELNKVIAQLS 994
Query: 539 KVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNS 597
+ +++ +N ++++ ++ID KI ++ L+L +++ +L E+ +E
Sbjct: 995 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN-LTLRKRNEELKEVE------EEGKQH 1047
Query: 598 LKSLNDVITREKETQASELERSCQVIKQN 626
LK + + + +++ +LE + IK+N
Sbjct: 1048 LKEMGQMQVLQMKSEHQKLEENIDNIKRN 1076
Score = 40.3 bits (90), Expect = 0.037
Identities = 49/266 (18%), Positives = 119/266 (44%), Gaps = 21/266 (7%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+++++ KE + S + ELD LK R KE++ + + D + L K +E+
Sbjct: 237 EAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSK----IMKLDNEIKALDSRKKQMEKDN 292
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
S L+E+ +E+ + D +N D + H V R V+ ++ L K +E
Sbjct: 293 SELEEK------MEKVFQGTDEQLN---DLYHNHQRTV-REKERKLVDCHRELEKLNKES 342
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETC 1005
R Q+ + + + + + + A+ ++ +LE + +R + + +
Sbjct: 343 RLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNF 402
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
+ +++R+E EAK A ++++ + ++ +KQI+ + + + +
Sbjct: 403 HKLVRERQE-----GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILS 457
Query: 1066 QNQ-QITDVMKENQKLKKMNAKLITI 1090
+ Q ++ +V E Q+L+ + +++ +
Sbjct: 458 KKQNELKNVKYELQQLEGSSDRILEL 483
Score = 35.5 bits (78), Expect = 1.1
Identities = 78/394 (19%), Positives = 157/394 (39%), Gaps = 35/394 (8%)
Query: 66 SSNEINLKL-EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S E+N KL + ++ +K + L+ + + Q R L Q L E + +
Sbjct: 850 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR 909
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSN-LIMENVTESDNLN------KEVDDLKKNNEC 177
EIK+ + + + + Q+E + L N N D LN K + K+ E
Sbjct: 910 EIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 969
Query: 178 LTQKCIDLEKLVNESE-NK-IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT 235
Q D E+E NK I + C + K K N L +T R + D+ T
Sbjct: 970 HIQDGKDDYMKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLT 1029
Query: 236 STRYNKICTLQSELDAGREDCKELCE-DFTSIKN-HLELHE--PNMTMDLDEKLGENNEF 291
+ N+ L+ + G++ KE+ + +K+ H +L E N+ + + LG +
Sbjct: 1030 LRKRNE--ELKEVEEEGKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGY 1087
Query: 292 ETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL 351
E + + E++ + +D ++Y++ ++ + E LD++
Sbjct: 1088 EEEIIHFKKELR--------------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKT 1133
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
+D I K+ +E+ K+ DL T + + + + S E +A + R
Sbjct: 1134 LDQAIMKFH---SMKMEEINKIIRDLWRSTYRGQDI--EYIEIRSDADENVSASDKRRNY 1188
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLS 445
R+ + +D+ + + +++L ++L+
Sbjct: 1189 NYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLA 1222
Score = 32.7 bits (71), Expect = 7.5
Identities = 19/96 (19%), Positives = 46/96 (47%)
Query: 926 RMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCK 985
R + +VE+ + +K +++ + K ++++ +T + + + K +E + L++
Sbjct: 202 RQTQGQKVEEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRL 261
Query: 986 AELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
E+E + +LD E + KQ E+ L+E
Sbjct: 262 KEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEE 297
>M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain
beta-subunit protein.
Length = 611
Score = 61.7 bits (143), Expect = 1e-08
Identities = 126/646 (19%), Positives = 254/646 (39%), Gaps = 50/646 (7%)
Query: 470 DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE--AHNEVKS 527
+AL + +R D ++ +E+ ET AKA + T E A +
Sbjct: 3 NALAHALQSARHDCDLLREQYEEET-EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 61
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
L E KL + ++ E + + ++ K + E ++ E+ N +
Sbjct: 62 LEEAKKKLAQ-RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD- 119
Query: 588 INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
K++ N K L + + +E+Q SELE S + + EL K+K
Sbjct: 120 ----KKQRNFDKILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETF 174
Query: 648 XXXXXXXXDEAKSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMR 702
+E L EQ + + E K + ++E+ E A +++
Sbjct: 175 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 234
Query: 703 LQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR 762
L+ Q+ E +++ E E KL E + E KR++ V L++S +A + + V+ +
Sbjct: 235 LRAQL-EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 293
Query: 763 IAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSI 822
+E D+ + + D L + + +D K +I
Sbjct: 294 ---MEGDLNEME---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 347
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSL 882
+++ + + L+ L + ++ + K D E +E +Q Q L +K +
Sbjct: 348 AIV-ERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKM 406
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK- 941
+ +S L+ ++ ++ V+ + A D A + + A +E+ K+ M+
Sbjct: 407 DADLSQLQTEV--EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 464
Query: 942 TIEELRYKKQD-----LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
TI++L+++ + LK ++QK + + + E EA++K + + + ++R K
Sbjct: 465 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 524
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTM 1056
EL Q EE K L + ++VDKL + A ++Q E +N +
Sbjct: 525 EL----------TYQTEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSK 571
Query: 1057 YVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
+ + + ++ D+ + ++ K+ AK I G G N E
Sbjct: 572 FRKVQHELDEAEERADIAE--SQVNKLRAKSRDI----GTKGLNEE 611
Score = 39.5 bits (88), Expect = 0.065
Identities = 87/448 (19%), Positives = 192/448 (42%), Gaps = 36/448 (8%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDI 84
+ L+ K + N IE ++ ++ + K ++ + E K E+ EL
Sbjct: 88 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWKQKYEESQSELESS 146
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
+++ +L + L + + +++ + EN +EI +LT+ L + K I+EL+
Sbjct: 147 QKEARSLSTELFKL---KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 203
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQ 204
+ L E + L + L+ + + ++ ++ E E K+ K+
Sbjct: 204 KVRKQLE---AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD---- 256
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
E + Q+ + + L S+ D+ T +R N+ ++ +++ D E+ E
Sbjct: 257 ----EEMEQAKR-NHLRVVDSLQTSL-DAETRSR-NEALRVKKKMEG---DLNEM-EIQL 305
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ--LINNESKKSK 322
S N + L L + AV+ ++K N+ + + L+ E ++ +
Sbjct: 306 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 365
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--IIN-KYQIDLDEILEKYTKVQGDLNE 379
+++ + S + D E TS V + N +IN K ++D D + + T+V+ + E
Sbjct: 366 AVVEQTERS-RKLADRELIETSERVQLLHSQNTSLINQKKKMDAD-LSQLQTEVEEAVQE 423
Query: 380 CTSELKSVNEKL--ASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEIL 437
C + + + + A++ ++ ++KE + ER+ + D+ + +E ++I
Sbjct: 424 CRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAEQIA 480
Query: 438 TKECLK-LSKLKIDIPRDLDQDLPAHKK 464
K K L KL+ + R+L+ +L A +K
Sbjct: 481 LKGGKKQLQKLEARV-RELENELEAEQK 507
>BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting
protein 1-like protein.
Length = 893
Score = 61.7 bits (143), Expect = 1e-08
Identities = 81/354 (22%), Positives = 156/354 (44%), Gaps = 35/354 (9%)
Query: 686 IKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK----LNELTNKYEALKRDYDAAVKD 741
IK E+ ++ N+ + R Q +D KL +EK +K L +L + + K++ + +
Sbjct: 150 IKMEEQCRDL-NKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 207
Query: 742 LESSREAVNQLTTQKDLVEGRIAELES-DIRTEQTATVXXXXXXXXXXXXXXXXXXXXXT 800
LE R QL+ + + ++ RI ELE+ + R E+T
Sbjct: 208 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE--------FTLKEDLTKLKTLTVM 259
Query: 801 FGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECET 860
F DE + + E K + ++ S S +V Q K ++ ++ +++ K K D E
Sbjct: 260 FVDERKTMSEKLKKTEDKLQAAS--SQLQVEQNKVTTVT-EKLIEETKRALKSKTDVEEK 316
Query: 861 CAEYLQERDEQCARLKKEKLS---LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA 917
+ERD+ +LK E+ L +V+ LK ++++ + +E+ + ++ +
Sbjct: 317 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 376
Query: 918 NLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK 977
LH E K K L + +E L+ K +D+K + K ++Y ++ + +
Sbjct: 377 ALHQ----------ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 426
Query: 978 RKELEDCKAELEELKQ---RYKELDEECETCAEYLKQREEQCKRLKEAKIALEI 1028
R + + ELE +K +YK L E+ ET E + Q + K ++ E+
Sbjct: 427 RDKAQFLSKELEHVKMELAKYK-LAEKTETSHEQWLFKRLQEEEAKSGHLSREV 479
Score = 61.3 bits (142), Expect = 2e-08
Identities = 121/582 (20%), Positives = 260/582 (44%), Gaps = 43/582 (7%)
Query: 53 ITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILET-QTRDLLMSQ 111
+T+ + Q L ++ E + KL + + +++ + LE + Q + Q +D +M++
Sbjct: 13 LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 72
Query: 112 IKSLEMENLTKDKEIKNLT---DSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV 168
+ + + +N +++ L+ D L+ ++ + + +EE + I + + + EV
Sbjct: 73 LTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEV 132
Query: 169 DDLKK---NNECLTQKCIDLEKLVNESENKIGPKNICAQ-CKLKENLIQSLHIGYDNTLS 224
++L+K + E ++ I +E+ + ++ + + ++ KL+ + + +
Sbjct: 133 EELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLED 192
Query: 225 KLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDE 283
N+S + Y+ C L+ E R K+L ++ S+K + EL ++ E
Sbjct: 193 AFNKSKQEC-----YSLKCNLEKE----RMTTKQLSQELESLKVRIKELEAIESRLEKTE 243
Query: 284 KLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTT 343
+ + + K + VM +R ++SE+L KK++D + + S L V + T
Sbjct: 244 FTLKEDLTKLKTLTVMFVDER--KTMSEKL-----KKTEDKL-QAASSQLQVEQNKVTTV 295
Query: 344 SLDVFEILMDNIINKYQIDLDEILEKYTKVQGDL-NECTSELKSVNEKLASLNSQLIEKE 402
+ + E + K + D++E + TK + DL N+ +E + N+ L+ +N +
Sbjct: 296 TEKLIEETKRAL--KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ 353
Query: 403 NACNILR-IQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
+ I + K ++++ S T + ++ N++KE L++E +L KLK+ + ++ DL
Sbjct: 354 SLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE-LSQEVERL-KLKLKDMKAIEDDL-- 409
Query: 462 HKKITILFDALITQYELSRTDYE-IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE 520
K ++ L +Y R + + KE ++ AK F L+E
Sbjct: 410 -MKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK-YKLAEKTETSHEQWLFKRLQE 467
Query: 521 AHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK 580
+ L E+ L K K+ E A +LI L + L+ + + E + L +
Sbjct: 468 EEAKSGHLSREVDAL-KEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIEN 526
Query: 581 LT-ELVSTINGLKEENNSL--KSLND--VITREKETQASELE 617
LT EL + K SL + ++D V ++E +T+A + E
Sbjct: 527 LTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 568
Score = 55.2 bits (127), Expect = 1e-06
Identities = 120/565 (21%), Positives = 229/565 (40%), Gaps = 53/565 (9%)
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKE 258
+ + AQ L+ IQ L T +KL +++++ K L+ EL +
Sbjct: 7 QRLTAQLTLQRQKIQELTTNAKETHTKL--ALAEARVQEEEQKATRLEKELQT---QTTK 61
Query: 259 LCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+D +I L +E + L +KL + + + + E R+L E+L + +
Sbjct: 62 FHQDQDTIMAKLT-NEDSQNRQLQQKLAALS----RQIDELEETNRSLRKAEEELQDIKE 116
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQI-DLDEILEKYTKVQGDL 377
K SK Y ++ + E LD+ + I + Q DL++ LE+ T D
Sbjct: 117 KISKGE---YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 173
Query: 378 NECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEIL 437
+L L L + + C L+ E+ + ++ ++ + +KE+
Sbjct: 174 KLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE 233
Query: 438 TKECLKLSKLKIDIPRDLDQDLPAHKKITILF-DALITQYE-LSRTDYEIE--KEKLRLE 493
E +L K + L +DL K +T++F D T E L +T+ +++ +L++E
Sbjct: 234 AIES-RLEKTEFT----LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVE 288
Query: 494 TGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENN---ANLNLI 550
V +EE V ++L K++ ++ N + +N++
Sbjct: 289 QNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
Query: 551 KILSEEIDALKIAIAKNE------EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
K + ++A++ KN+ + +L +++NK+ EL + LK + +K++ D
Sbjct: 349 KNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDD 408
Query: 605 ITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ 664
+ + E + LER + ++ KA L ++ ++ EQ
Sbjct: 409 LMKT-EDEYETLERR--------YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQ 459
Query: 665 NLALKEQCEE-KTRDCSRL--EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKL 721
L + Q EE K+ SR + K HE A +I LQ D ++K KL
Sbjct: 460 WLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT--EDLICHLQ-----GDHSVLQK--KL 510
Query: 722 NELTNKYEALKRDYDAAVKDLESSR 746
N+ N+ L R+ + K+LE R
Sbjct: 511 NQQENRNRDLGREIENLTKELERYR 535
Score = 50.4 bits (115), Expect = 3e-05
Identities = 65/276 (23%), Positives = 115/276 (41%), Gaps = 19/276 (6%)
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKE------KLSL 882
E +L +L +Q++ +L KE + +QE +++ RL+KE K
Sbjct: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 64
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDE-DWAN--LHSVVVDRMSYDAEVEK---- 935
+Q K Q + Q K A ++ DE + N L + ++ K
Sbjct: 65 DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG 124
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
N +M +EELR + D++ ++ K E+ +K E + + +D K E+E+L +R
Sbjct: 125 NAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
Query: 996 KELDEECETCAEYLKQR--EEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL-SNTPVS 1052
L E+ E KQ +C KE ++ +L + KV + K++E++ S +
Sbjct: 185 MAL-EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI-KELEAIESRLEKT 242
Query: 1053 NSTMYVATGSAIVQNQQITDVMKE-NQKLKKMNAKL 1087
T+ D K ++KLKK KL
Sbjct: 243 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKL 278
Score = 44.8 bits (101), Expect = 0.002
Identities = 48/265 (18%), Positives = 126/265 (47%), Gaps = 17/265 (6%)
Query: 825 ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQ 884
++++ V + +++ ++EL ++ + D T L D Q +L+++ +L +
Sbjct: 36 LAEARVQEEEQKATRLEKELQTQTTKFHQDQD---TIMAKLTNEDSQNRQLQQKLAALSR 92
Query: 885 QVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE 944
Q+ L+E R+ + E + + ++ E + N + AEVE+ ++ + +E
Sbjct: 93 QIDELEETNRSLRKAEEELQDIKEKISKGE-YGNAGIM--------AEVEELRKRVLDME 143
Query: 945 ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECET 1004
+ ++ + K +E+ T + K+F+ + ++L LE+L+ + + +EC +
Sbjct: 144 GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS 203
Query: 1005 CAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNST-MYVATGSA 1063
L++ K+L + +L++ K + A+E ++E T + T + T
Sbjct: 204 LKCNLEKERMTTKQLSQELESLKVRIK---ELEAIESRLEKTEFTLKEDLTKLKTLTVMF 260
Query: 1064 IVQNQQITDVMKENQ-KLKKMNAKL 1087
+ + + +++ +K+ + KL+ +++L
Sbjct: 261 VDERKTMSEKLKKTEDKLQAASSQL 285
>AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein.
Length = 1620
Score = 61.7 bits (143), Expect = 1e-08
Identities = 167/799 (20%), Positives = 326/799 (40%), Gaps = 74/799 (9%)
Query: 34 NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK--EQKSAL 91
N IIE + ++L+D +T + K+ L+E + N +++ + EL + K E++S+
Sbjct: 316 NTKIIEEEKKTLELKDK--LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 373
Query: 92 EGKY-QNLILETQTRDLLMSQ-----IKSLEMENLTKDKEIKNLTDSL------KTKSKK 139
E K + E Q R+ SQ ++ +E E K ++++ D + + K +
Sbjct: 374 EIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL 433
Query: 140 INE---LQEENDTLSNLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN- 194
I + EE T MEN S N+ D +K N + + I L+ ++ E
Sbjct: 434 IRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 493
Query: 195 --KIGP--KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD--SNTSTRYNKICT---L 245
++G + CA + E+L++ L + + + ++I++ S + + + T L
Sbjct: 494 KEELGLILEEKCALQRQLEDLVEELSFSREQ-IQRARQTIAEQESKLNEAHKSLSTVEDL 552
Query: 246 QSELDAGREDCKELC----EDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVK--VM 299
++E+ + E KEL + T+ K LE+ E LD ++ E+ E E + ++ ++
Sbjct: 553 KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD-RMAESQEAELERLRTQLL 611
Query: 300 SEIKRNLNSLSEQL-----INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+ L+ L E L IN E K KD++ + + L E + ++ + DN
Sbjct: 612 FSHEEELSKLKEDLEIEHRINIE--KLKDNLGIHYKQQIDGLQNEM-SQKIETMQFEKDN 668
Query: 355 IINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKER 414
+I K + EI + Q +N + E+ +L L ++E L + +
Sbjct: 669 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 728
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT-----ILF 469
+ + + + +KEN+L+E + + S LK D + L+ L H ++ I
Sbjct: 729 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILK-DEKKTLEDMLKIHTPVSQEERLIFL 787
Query: 470 DALITQYELSRTDYEIE-----KEKLRLETGTAKAVXXXXXXXXXXXXXXFDT-LEEAHN 523
D++ ++ + S + EIE E L+ + F+ +E
Sbjct: 788 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 847
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
E L + L SK + + +K L+EE+ +I + K E + E
Sbjct: 848 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 907
Query: 584 LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXX 643
+ ++++ L +V REK + L + +KQ E+ + ++
Sbjct: 908 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV----KS 963
Query: 644 XXXXXXXXXXXXDEAKSLLEQNLALKEQ-CEEKTRDCSRLEINIKTHEKTAEIQNRMIMR 702
E + ++ N A Q C+ T+ S L+ + + AE + +
Sbjct: 964 LKQEKEQVSLRCRELEIIINHNRAENVQSCD--TQVSSLLDGVVTMTSRGAE---GSVSK 1018
Query: 703 LQKQIQEDDKLFIEKETKLNELT----NKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+ K E+ K+ +E + +T +K E L D+ +V ESS A K
Sbjct: 1019 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRATQPSENDKLQ 1077
Query: 759 VEGRIAELE-SDIRTEQTA 776
E + + E +D+R + A
Sbjct: 1078 KELNVLKSEQNDLRLQMEA 1096
Score = 60.9 bits (141), Expect = 2e-08
Identities = 153/818 (18%), Positives = 329/818 (40%), Gaps = 68/818 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ ++ + L + ++N T S S + LQ + L++ + + E D+L ++
Sbjct: 216 SQKLQIQFQQLQASETLRNSTHS----STAADLLQAKQQILTH--QQQLEEQDHL---LE 266
Query: 170 DLKKNNECLTQKCIDLEKLVN----ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
D +K E T + L++ + E + K+ N + + KE +I+ L+ + +
Sbjct: 267 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNT---KIIEE 322
Query: 226 LNRSISDSNTSTRYNKIC-TLQSELDAGREDCKELCEDFTSIKN--HLELHEPNMTMDLD 282
+++ + T +K+ LQ ++ ++ K + + T+ K E M
Sbjct: 323 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 382
Query: 283 EKLGENN----EFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
E+L + N +FET V+ M E +R L L +L + I + K L+
Sbjct: 383 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHM 438
Query: 338 AEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ + M+N + Y I ++E K V +NE +L+ N + L
Sbjct: 439 AQMEEMKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKE 495
Query: 397 QL-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
+L + E C + R ++ + E+S S I ++ +E E K D+ +
Sbjct: 496 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 555
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
+ + K++ + +A +T Y++ +EKEK + A++
Sbjct: 556 IVSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLRT----- 608
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 609 -QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF- 664
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 665 -EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 723
Query: 635 ADI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTH 689
++ L ++ L +N LK+ E+KT D ++ +
Sbjct: 724 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQE 781
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESS 745
E+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 782 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 841
Query: 746 REAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXX 798
+ + + L KD +E + E + +++ A +
Sbjct: 842 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 901
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
TF E ++GE + D + ++ E +L +RL ++ LK+++ E+
Sbjct: 902 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLN 958
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
E QE+++ R ++ ++ + + + TQ
Sbjct: 959 EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 996
Score = 58.0 bits (134), Expect = 2e-07
Identities = 113/585 (19%), Positives = 247/585 (42%), Gaps = 48/585 (8%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLSEKDNKLTEL 584
S +E K+Y+ + D+ N N +I +E I+ L I + E+K L L +K +L
Sbjct: 280 SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 339
Query: 585 VSTING-LKEENNSLKSLNDVIT--REKETQASE----LERSCQVIKQNGFELDKMKADI 637
+ + + ++N +K++ +T ++KE Q+SE L + + +++ + + + DI
Sbjct: 340 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 399
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ E + Q + +Q E + +++E +KT K E++N
Sbjct: 400 VQRMEQETQRKLEQLRA--ELDEMYGQQIVQMKQ-ELIRQHMAQME-EMKTRHK-GEMEN 454
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-K 756
+ + ED + +NEL K + + ++L E L Q +
Sbjct: 455 ALRSYSNITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 512
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
DLVE E R QT DL
Sbjct: 513 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV------------EDLKAEIVSAS 560
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETC-AEYLQERDEQCAR 874
++ + + ++EV+ K +L ++E + + +R E + E E + L +E+ ++
Sbjct: 561 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 620
Query: 875 LKKEKLSLEQQVS--NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK E L +E +++ LK+ + + +++ + +++ + E
Sbjct: 621 LK-EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 679
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ K K L +++ + K +++ + ++QK +E +++KE +E+++ + + E L+
Sbjct: 680 ISKLKDLQQSL--VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 737
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
++ KE + + + E Q E + LK+ K LE + K+ + V+ E+++ L +
Sbjct: 738 KQMKEKENDLQ---EKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSK 793
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
+ V ++I +++EN+ LK+ +L +K+ T
Sbjct: 794 SKDS--------VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 830
Score = 52.8 bits (121), Expect = 7e-06
Identities = 158/729 (21%), Positives = 309/729 (42%), Gaps = 63/729 (8%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 645 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 704
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 705 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 761
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 762 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 821
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+ + + N A+ + N Q L Y L K+ + DS +
Sbjct: 822 EEIEKQRNTFS----FAEKNFEVN-YQELQEEY-ACLLKVKDDLEDSKNKQELE----YK 871
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEI-KR 304
S+L A E+ + T++K + + + T + ++GE E +T + E+ KR
Sbjct: 872 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 931
Query: 305 NLNSLSEQLIN-NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID- 362
LS++L + +E K K + + + L E SL E ++ IIN + +
Sbjct: 932 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE--LEIIINHNRAEN 989
Query: 363 LDEILEKYTKVQGDLNECTS-----ELKSVNEKLASLNSQLIEKENACNILRIQKERIHE 417
+ + + + + TS + VN+ + ++E + + + + +E E
Sbjct: 990 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1049
Query: 418 ISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI--TQ 475
+ V KE+ L+ E KL K ++++ + DL + + +L+ T
Sbjct: 1050 QLILDHLPSVTKESSLRATQPSENDKLQK-ELNVLKSEQNDLRLQMEAQRICLSLVYSTH 1108
Query: 476 YELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEE 531
+ R E EK+K L+ E A+ +E +E K LH
Sbjct: 1109 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1168
Query: 532 LTKLYKSKVDENNANL-NLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
+ KL K+ +E + L L +L E ALK + +++ +N+ EL
Sbjct: 1169 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1228
Query: 590 GLKEENNSLKSLNDVITRE------KETQASEL--ERSCQVIKQNGFE-LDKMKADILMX 640
+++ ++ +L + +T E +T+ S++ +++ + + G E L K + + L
Sbjct: 1229 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1288
Query: 641 XXXXXXXXXXXXXXXDEAKSLLE-QNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ SL + + L+EQ +E S L+ +K E+ E +
Sbjct: 1289 HSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE--- 1345
Query: 700 IMRLQKQIQ 708
I LQK++Q
Sbjct: 1346 IHCLQKRLQ 1354
Score = 46.8 bits (106), Expect = 4e-04
Identities = 108/523 (20%), Positives = 224/523 (42%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 345 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 403
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 404 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNI 462
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 463 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 522
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 523 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 582
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L TQ E +++L+ D+ E +
Sbjct: 583 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 642
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 643 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 698
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 699 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 753
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 754 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 813
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 814 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 856
Score = 44.0 bits (99), Expect = 0.003
Identities = 89/420 (21%), Positives = 180/420 (42%), Gaps = 50/420 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLE----INIKTHEKTAE--IQ-NRMIMRLQKQIQE 709
E + + L L EQ ++ +L+ + TH TA +Q + I+ Q+Q++E
Sbjct: 201 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 260
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D L + + K + T + L+ V ++E ++ N + E I EL +
Sbjct: 261 QDHLLEDYQKKKEDFTMQISFLQEKIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTK 318
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
I E+ T+ +N+++ +N KL+ + + S E
Sbjct: 319 IIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEI-KNMKLELTNSKQKERQSSEE 374
Query: 830 VSQL--------KERLLSCQQELDDLKERYKELDDECETCAEYLQER-DEQCARLKKEKL 880
+ QL K Q E D ++ +E + E L E +Q ++K+E +
Sbjct: 375 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 434
Query: 881 SLEQQVSNLKE-QIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMSY---DAEVEK 935
Q ++ ++E + R + +E + ++++ VN ED L +V ++ ++ D +K
Sbjct: 435 --RQHMAQMEEMKTRHKGEMENALRSYSNITVN--EDQIKLMNVAINELNIKLQDTNSQK 490
Query: 936 NK---RLMKTIEE---LRYKKQDLKNTVT----KMQKAMEKYTKKDKEFEAKRKEL---E 982
K L +EE L+ + +DL ++ ++Q+A + +++ + K L E
Sbjct: 491 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 550
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-NQKVALEK 1041
D KAE+ + KEL+ + E K + E ++ K A ++D+++ +Q+ LE+
Sbjct: 551 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA-----VLDRMAESQEAELER 605
Score = 37.5 bits (83), Expect = 0.26
Identities = 47/221 (21%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE- 900
Q+L + + K+ D LQ+ + +E L L +Q L+ Q + Q E
Sbjct: 172 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 231
Query: 901 -RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + A A+L +++ ++E+ L +E+ + KK+D ++
Sbjct: 232 LRNSTHSSTA-------ADLLQAKQQILTHQQQLEEQDHL---LEDYQKKKEDFTMQISF 281
Query: 960 MQKAMEKY-TKKDKEFEAKRKE--------LEDCKAELEELKQRYKELDEECETCAEYLK 1010
+Q+ ++ Y ++DK+ E KE +E+ ++ E +++ EL ++ T + L
Sbjct: 282 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 341
Query: 1011 QREEQ-CKRLKEAK-IALEIVDKLSNQKVALEKQIESLSNT 1049
+ +EQ ++ +E K + LE+ + ++ + E +I+ L T
Sbjct: 342 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSE-EIKQLMGT 381
>AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein.
Length = 1559
Score = 61.7 bits (143), Expect = 1e-08
Identities = 141/723 (19%), Positives = 297/723 (41%), Gaps = 68/723 (9%)
Query: 39 ETQSNPIKLQDSGTITISCK-MCQSLKESSNEINLKLEKLSGELFDIKEQKSAL-EGKYQ 96
ETQ + ++ QD T C + +SL+++ E++ + +K L DI+EQ L E K Q
Sbjct: 45 ETQRSLLE-QDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ 103
Query: 97 NLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDS-LKTKSKKINELQEENDTLSNLIM 155
+ + L+M+Q++ E+L + +L +S L+ E + + + ++
Sbjct: 104 EYQAQVEEMRLMMNQLE----EDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLL 159
Query: 156 ENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSL 215
+ D EV + K + ++ + +++L + E K + A + E L+Q++
Sbjct: 160 K---AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLE-----KAVKASTEATE-LLQNI 210
Query: 216 HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEP 275
+ +L + + ++S K EL+ + + + HLE+H
Sbjct: 211 RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQ-------HLEVHLK 263
Query: 276 NMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAV 335
+EK+ + + K +++ K L ++ ++ + E K I + +++
Sbjct: 264 QKEQHYEEKI---KVLDNQIKKDLAD-KETLENMMQR--HEEEAHEKGKILSEQKAMINA 317
Query: 336 LDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLN 395
+D++ + + E+ + NK + ++ K Q E SEL+ L +
Sbjct: 318 MDSKIRSLEQRIVEL---SEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQA 371
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+L E +N L Q E+I + +++ E L+E+ L+ + K+++ R L
Sbjct: 372 GKL-EAQN--RKLEEQLEKISHQDHSDKNRLLELETRLREV----SLEHEEQKLELKRQL 424
Query: 456 DQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX- 514
+ + ++ AL Q + + ++ + K LE TA+A
Sbjct: 425 TELQLSLQERESQLTAL--QAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR 482
Query: 515 -FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLS 573
FD L + + L E+L +L + + NN N L K L E A N+E +
Sbjct: 483 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDE-------ASGANDEIVQL 535
Query: 574 LSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE D+ E+ L + ++++L T +E Q +LE + + + +
Sbjct: 536 RSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE-QVMDLEALNDELLEKERQWEAW 594
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
++ + E + +L+ + + +++ + SR + + E A
Sbjct: 595 RSVL-------GDEKSQFECRVRELQRMLDTEKQSRARADQRITE-SRQVVELAVKEHKA 646
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
E I+ LQ+ ++E KLN+L K+ L+ + + + LE+ RE +L
Sbjct: 647 E-----ILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLL 701
Query: 754 TQK 756
++
Sbjct: 702 EEQ 704
Score = 49.2 bits (112), Expect = 8e-05
Identities = 61/273 (22%), Positives = 116/273 (42%), Gaps = 16/273 (5%)
Query: 827 DSEVSQLKERLLSCQQELDDLKER-YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
D + QL + ++L ++KE+ Y+ +E L+E D AR + + E +
Sbjct: 80 DDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEE-DLVSARRRSDLYESELR 138
Query: 886 VSNLKEQIRTQQPVERQAKFA---DVAVNTDEDWANLHSVVVDRMSYDAEV-EKNKRLMK 941
S L + ++ E Q K D ++A L + ++ E+ EK ++ +K
Sbjct: 139 ESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVK 198
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
E Q+++ + ++ +EK ++ E RK+L E EEL+++++E
Sbjct: 199 ASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL----VEAEELEEKHREAQVS 254
Query: 1002 CETCAEYLKQRE---EQCKRLKEAKIALEIVDK--LSNQKVALEKQIESLSNTPVSNSTM 1056
+ +LKQ+E E+ ++ + +I ++ DK L N E++ M
Sbjct: 255 AQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAM 314
Query: 1057 YVATGSAIVQNQQITDVMKENQKLKKMNAKLIT 1089
A S I +Q + E KL N+ L T
Sbjct: 315 INAMDSKIRSLEQRIVELSEANKL-AANSSLFT 346
Score = 47.2 bits (107), Expect = 3e-04
Identities = 111/547 (20%), Positives = 214/547 (39%), Gaps = 65/547 (11%)
Query: 520 EAHNEVKSLHEELTKLYKSKVDENNANLNL---IKILSEEIDALKIAIAKN-EEKMLSLS 575
EA N + L E+L K+ + N L L ++ +S E + K+ + + E LSL
Sbjct: 375 EAQN--RKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 432
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
E++++LT L + L+ + K+ E E +E E Q + + E+ +
Sbjct: 433 ERESQLTALQAARAALESQLRQAKT-------ELEETTAEAEEEIQALTAHRDEIQRKFD 485
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINIKTHEKTAE 694
+ ++ L QN L +Q +E + + ++ + E
Sbjct: 486 ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 545
Query: 695 IQNR-MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
I R M + QKQ E K T L E EAL + + E+ R +
Sbjct: 546 ITEREMQLTSQKQTMEALKTTC---TMLEEQVMDLEALNDELLEKERQWEAWRSVLGD-- 600
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
+K E R+ EL+ + TE+ + E+R + E
Sbjct: 601 -EKSQFECRVRELQRMLDTEKQSRARADQRIT------------------ESRQVVELAV 641
Query: 814 LDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
+ K I + + + + K + S +L+DL++++ L+ + + L+ E
Sbjct: 642 KEH--KAEILALQQA-LKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ 698
Query: 874 RLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
RL +E+ L+QQ+ K I R Q ++ AD+ D + Y E
Sbjct: 699 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD-----------LEYQLE 747
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAME-KYTKKDKEFEAKRKELE--DCKAELE 989
N +++ + E+++ ++ T+++ K ++ K D+ + K+ L+ + K LE
Sbjct: 748 ---NIQVLYSHEKVK-----MEGTISQQTKLIDFLQAKMDQPAKKKKVPLQYNELKLALE 799
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
+ K R EL+E + L+ E+ K + Q++A+ + S +
Sbjct: 800 KEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQ 859
Query: 1050 PVSNSTM 1056
P + S +
Sbjct: 860 PSAMSLL 866
Score = 47.2 bits (107), Expect = 3e-04
Identities = 73/351 (20%), Positives = 152/351 (43%), Gaps = 27/351 (7%)
Query: 56 SCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSL 115
SC + L+E N++ +L+ + F + +Q G ++ D L +I
Sbjct: 490 SCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER 549
Query: 116 EMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNN 175
EM+ LT K+ ++LKT + E + + L++ ++E + + + D K
Sbjct: 550 EMQ-LTSQKQ---TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF 605
Query: 176 ECLT---QKCIDLEKLVN-ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLN-RSI 230
EC Q+ +D EK ++ +I + +KE+ + L + KL S+
Sbjct: 606 ECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL 665
Query: 231 SDS-NTSTRYNKIC-----TLQSELDAGREDCKELCEDFTSIKNHLEL---HEPNMTMDL 281
SD N + + + +LQ +L+ RE + L E+ ++ ++L H +T L
Sbjct: 666 SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 725
Query: 282 DEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFG 341
E L + +T+ S+++ L ++ + L ++E K + I + + L+ L A+
Sbjct: 726 QEALDRADLLKTE----RSDLEYQLENI-QVLYSHEKVKMEGTISQ-QTKLIDFLQAKMD 779
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
+ L N+ ++ L++ + +++ L + EL+S E+ A
Sbjct: 780 QPAKKKKVPLQ---YNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 827
Score = 37.1 bits (82), Expect = 0.35
Identities = 46/203 (22%), Positives = 86/203 (42%), Gaps = 6/203 (2%)
Query: 841 QQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE 900
+Q+ +E+ K LD++ + + + R ++E + +S K I
Sbjct: 263 KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 322
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-MSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + V ++ A S+ R M E+ R K E + K + +N K
Sbjct: 323 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR--K 380
Query: 960 MQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETCAEYLKQREEQCKR 1018
+++ +EK + +D + + ELE E+ E +++ EL + L++RE Q
Sbjct: 381 LEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTA 440
Query: 1019 LKEAKIALEIVDKLSNQKVALEK 1041
L+ A+ ALE +L K LE+
Sbjct: 441 LQAARAALE--SQLRQAKTELEE 461
>Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein.
Length = 2115
Score = 60.9 bits (141), Expect = 2e-08
Identities = 193/1063 (18%), Positives = 419/1063 (39%), Gaps = 81/1063 (7%)
Query: 58 KMCQSLKESSNEINLKLEKLS---GEL-FDIKEQKSALEGKYQNLILETQ-----TRDLL 108
K CQ LK ++++ K+ +LS G+L F ++E S L+ L T+ T++ L
Sbjct: 297 KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWL 356
Query: 109 MSQIK-SLEMENLTKDK---EIKN--LTDSLKTKSKKINELQEENDTLSNLIMENVTESD 162
Q + E+ +DK E KN L L + +++LQ+ ++ +V + +
Sbjct: 357 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416
Query: 163 NLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNT 222
L +E L NN L + LE + E K+ + + ++ + SL ++
Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER--GHFEEEKQQLSSLITDLQSS 474
Query: 223 LSKLNRSISDSNTSTRYN------KICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
+S L+++ + +++ + ++ +L SEL ++ ++ +K + +
Sbjct: 475 ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ 534
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVL 336
+ L ++ + + ++ S +K+ L E E+ + +DH + A
Sbjct: 535 LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR-QDHAQQLAT---AAE 590
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC--TSELKSVNEKLASL 394
+ E D ++ + + L EIL++ +V + + TS ++ EK A L
Sbjct: 591 EREASLRERDAALKQLEALEKEKAAKL-EILQQQLQVANEARDSAQTSVTQAQREK-AEL 648
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
S+ +E+ AC + ++ HE + V ++ +E ++ KE + K
Sbjct: 649 -SRKVEELQAC--VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK------DQ 699
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXX 510
L + L A K+ + + + + D E+++ L+ ET +
Sbjct: 700 LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
LE ++ H+ T++ + ++ E A + + E++ +K A E
Sbjct: 760 ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL--VKEVAAWRERY 817
Query: 571 MLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFEL 630
S E+ + LKEE K+ ++ +++ E Q+ +Q EL
Sbjct: 818 EDSQQEEAQYGAMFQEQLMTLKEECE--KARQELQEAKEKVAGIESHSELQISRQQN-EL 874
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
++ A++ D+ +L E+ A +++ +RLE ++
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT-------SKEVARLETLVRKAG 927
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK--YEALKRDYDAAVKDLESSREA 748
+ E +R +++ + + ++E++ + + +A++R+ + +LE R A
Sbjct: 928 EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987
Query: 749 VNQLTTQKDLVEGR----IAELESDI-RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+ + Q+ G+ +A L + R + + F
Sbjct: 988 LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L + + ++ + E +Q+KE L +Q + LKE+ + + E + +
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKE-LEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
E + + +L +VS L++Q + QQ QA + ++ +
Sbjct: 1107 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ---EQADSLERSLEAERASRAERDSA 1163
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELED 983
++ + E EK + L + L +++L TK+Q ++K + E++A ++
Sbjct: 1164 LETLQGQLE-EKAQELGHSQSALASAQRELAAFRTKVQD----HSKAEDEWKA---QVAR 1215
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+ E E L+EE + ++E + K LK L + + +QK LE+++
Sbjct: 1216 GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR----LVMAESEKSQK--LEERL 1269
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAK 1086
L SNS SA+ + Q E Q++ N +
Sbjct: 1270 RLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLR 1312
Score = 57.2 bits (132), Expect = 3e-07
Identities = 182/995 (18%), Positives = 376/995 (37%), Gaps = 68/995 (6%)
Query: 100 LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
LE + + L + +SL M K+ ++L +KIN+L EEN LS + E +
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGY 219
L +++L + + TQ+ ++ + + + + C + K ++Q
Sbjct: 333 HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE--EKNEILQGKLSQL 390
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTM 279
+ LS+L N ++ +L+ +++ L + T ++ +E+ E
Sbjct: 391 EEHLSQL-----QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ 445
Query: 280 DLDEKLGENNEFETKAVKVMS---EIKRNLNSLSE--QLINNESKKSKDHIDRYKDSLLA 334
+ L E FE + ++ S +++ ++++LS+ + + S+ + SL +
Sbjct: 446 QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS 505
Query: 335 VLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
L T E+ + + Q L + L++ + L +L S ++
Sbjct: 506 ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ 565
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
++ EK+ A + +++ + + +++ LK++ E K +KL+I + +
Sbjct: 566 QLKEVAEKQEATR--QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI-LQQ 622
Query: 454 DLDQDLPAHKKI-TILFDALITQYELSRTDYEIEK--EKLRLETGTAKAVXXXXXXXXXX 510
L A T + A + ELSR E++ E R E A+A
Sbjct: 623 QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKS-KVDENNANLNLIKILSEEIDALKIAIAKNEE 569
E E L E+L L +S KV + + + ++ ++ + I++ +
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEK-RRAADALEEQQRCISELKA 741
Query: 570 KMLSLSEKDNK-LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ SL E+ + EL G K L+ L + E E EL +
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 801
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E +++ ++ EQ + LKE+CE+ ++ + +
Sbjct: 802 ECEQLVKEV---AAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
Query: 689 HEKTAEI----QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD--- 741
E +E+ Q + L + + EKE + +L + L+ A K+
Sbjct: 859 IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
Query: 742 LES--SREAVNQLTTQKDLVE--GRIAELESDIRTEQ-------TATVXXXXXXXXXXXX 790
LE+ + Q T ++LV+ R + + + EQ T
Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL---DDL 847
+ + E + + R ++ E+ + E+ + L
Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
Query: 848 KERYKELDDECETCAEYLQE---RDEQCARLK-------KEKLSLEQQVSNLKEQIRTQQ 897
E+ E E A L E +D++ A+L+ KE L Q V LKEQ+ ++
Sbjct: 1039 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098
Query: 898 PVERQAKFA--DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR----LMKTIEELRYKKQ 951
A + A T+ L ++ + + + +K + L +++E R +
Sbjct: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158
Query: 952 DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE-ECETCAEYLK 1010
+ + + +Q +E +K +E + L + EL + + ++ + E E A+ +
Sbjct: 1159 ERDSALETLQGQLE---EKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1215
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
R+E +R +LE + N++V LEK+ ES
Sbjct: 1216 GRQE-AERKNSLISSLEEEVSILNRQV-LEKEGES 1248
Score = 50.4 bits (115), Expect = 3e-05
Identities = 181/981 (18%), Positives = 390/981 (39%), Gaps = 95/981 (9%)
Query: 103 QTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKK---INELQEENDTLSNLIMENV 158
QT M ++K L E +D+ L ++ K ++K I +Q+ D L+ L+ E
Sbjct: 210 QTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQ 268
Query: 159 TESDNLNKEVDDLKKNNECLT-------QKCIDLEKLVNESE---NKIGPKNICAQCKLK 208
S KE+++L+ NE LT ++C DL+ ++ + N++ +N KL+
Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
Query: 209 E--NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE----- 261
E + +Q L + L++L S + T K L+ EL A +D K L E
Sbjct: 329 EFASHLQQL----QDALNELTEEHSKA-TQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
Query: 262 --DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM------SEIKRNLNSLSEQL 313
+ ++ HL + N + E LG+ + ET + ++++ + L +
Sbjct: 384 QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443
Query: 314 INNESK--KSKDHIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
E+K + H + K L +++ D + ++L + + + Q + +
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK---EELEQASQAHGARLTAQV 500
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI-----HEISSAVTID 425
+ +L + ++ +++LA L Q EK+ Q+E+ H++ ++
Sbjct: 501 ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ-LSSS 559
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ +KE +LKE+ K+ + D + L + DA + Q E +
Sbjct: 560 LKQKEQQLKEVAEKQ----EATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ E L+ + A L E+++ E + + + A
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC-VETARQEQHEAQAQVA 674
Query: 546 NLNLIKILSEEIDAL-KIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
L L ++ SE+ A K +A+ +++ L E+ L E + G EE + D
Sbjct: 675 ELEL-QLRSEQQKATEKERVAQEKDQ---LQEQLQALKESLKVTKGSLEEEK--RRAADA 728
Query: 605 ITREKETQASELERSCQVI----KQNGFELDKMKA-----DILMXXXXXXXXXXXXXXXX 655
+ E++ SEL+ + + K+ EL++ +A + +
Sbjct: 729 L-EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR 787
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCS----RLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+ A+++ Q+ A + +CE+ ++ + R E + + + + +M L+++ ++
Sbjct: 788 ELAEAMAAQHTA-ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ E + K+ + + E + +L ++ Q +K++ R +L D+
Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV---RAQKLADDLS 903
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP-KLDDSPKRSISVISDSEV 830
T Q T +R+L + P + D + +
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQET---ASRELVKEPARAGDRQPEWLEEQQGRQF 960
Query: 831 SQLKERLLSCQQELDDLKERYKELDDE-CETCAEYLQERDEQ---CARLKKEKLSLEQQV 886
+ L + ++E + + + L E+ + +ER +Q ARL +E+ + +
Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL----MKT 942
+ L++ R + + Q + V L + ++ D E+ K + L +K
Sbjct: 1021 A-LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE 1079
Query: 943 IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK----ELEDCKAELEELKQRYKEL 998
+EELR + LK + K +K + E + + +LE +AE+ +L+Q+ ++
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
Query: 999 DEECETCAEYLK-QREEQCKR 1018
E+ ++ L+ +R + +R
Sbjct: 1140 QEQADSLERSLEAERASRAER 1160
Score = 49.2 bits (112), Expect = 8e-05
Identities = 127/687 (18%), Positives = 261/687 (37%), Gaps = 46/687 (6%)
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI--DIPRDLDQDL 459
+NA N R++ + E + + K+ EL ++ E ++ +L+ + L + L
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
Query: 460 PAHKKITILFDALITQYELSRTDYEIEK-EKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
+K ++ RT+ K E LR E + +
Sbjct: 1095 AKKEKEHASGSGAQSE-AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAI---AKNEEKMLSLS 575
+ E S E L + K E + + + E+ A + + +K E++ +
Sbjct: 1154 RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
+ + E +++ EE S+ LN + EKE ++ EL+R + +L++ +
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSI--LNRQVL-EKEGESKELKRLVMAESEKSQKLEE-RL 1269
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH-EKTAE 694
+L + + +L E+ +L+E+ E++ L + + E+ E
Sbjct: 1270 RLLQAETASNSARAA-----ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324
Query: 695 IQNRMIMRLQKQIQEDDKLF-IEKE-TKLNELTNKY-------EALKRDYDAAVK----D 741
+ + +K Q++ L ++ E T L ++ + L+ + AA K +
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384
Query: 742 LESSREAVNQLTTQKDLVE---GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXX 798
LE S++A L + + G + L + ++
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
Query: 799 XTFGDENRDLGENPKLDDS-PKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDE 857
+ENR LGE L + + + V +L + L +++ + E
Sbjct: 1445 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1504
Query: 858 CETC-AEYLQERD---EQCARLKKEKLSLEQQVSNLK--EQIRTQQPVERQAKFADVAVN 911
E A+Y + E+ R ++E+ L QV L+ ++ +T+Q E K AD
Sbjct: 1505 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQA 1564
Query: 912 TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKK 970
+ L +V E ++ + + ++ +L K+Q ++ +M+KA Y K
Sbjct: 1565 SKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK 1624
Query: 971 DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-V 1029
++ +EL++ LE+L++ KEL E E L+Q + K ++ L V
Sbjct: 1625 KQQ----NQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680
Query: 1030 DKLSNQKVALEKQIESLSNTPVSNSTM 1056
L Q ++Q+ L V+ +
Sbjct: 1681 RSLEAQVAHADQQLRDLGKFQVATDAL 1707
Score = 48.4 bits (110), Expect = 1e-04
Identities = 100/592 (16%), Positives = 230/592 (38%), Gaps = 41/592 (6%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
D L+ +++ L ++L +S DE L + L E DA + + +++ L+
Sbjct: 207 DILQTPQFQMRRLKKQLAD-ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLN 265
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
EK + L+++N SL + E + CQ +K ++D+
Sbjct: 266 EKQAASPLEPKELEELRDKNESLTM-----------RLHETLKQCQDLKTEKSQMDRKIN 314
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ + + L + L E+ + T++ + ++ E +A +
Sbjct: 315 QLSEENGDLSFKLREFASHLQQLQDALNE---LTEEHSKATQEWLEKQAQLEK-ELSAAL 370
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
Q++ + + +I + KL + E L++L + K + V LE+ ++ L
Sbjct: 371 QDKKCLEEKNEILQG-KLS-QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R+ LE++ R +Q A + DL +
Sbjct: 429 NTQLQARVEMLETE-RGQQEAKLLAERGHFEEEKQQLSSLIT---------DLQSSISNL 478
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
K + S + ++L ++ S EL L ++ D E + +E+ Q A+
Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538
Query: 876 KKEKLSLEQQVSNLKEQIRT--QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+++ Q + + EQ+ + +Q ++ + A+ T +D A + + +A +
Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER--EASL 596
Query: 934 EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQ 993
+ +K +E L K K++ ++ ++ ++ + + + E EL +
Sbjct: 597 RERDAALKQLEALE------KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650
Query: 994 RYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN 1053
+ +EL ET + + + Q L E ++ E ++VA EK +
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAEL-ELQLRSEQQKATEKERVAQEKD-QLQEQLQALK 708
Query: 1054 STMYVATGSAIVQNQQITDVMKENQK-LKKMNAKLITICKKRGKTGANRENE 1104
++ V GS + ++ D ++E Q+ + ++ A+ ++ ++ + E E
Sbjct: 709 ESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
>X04201-1|CAA27798.1| 285|Homo sapiens protein ( Human skeletal
muscle 1.3 kb mRNA for tropomyosin. ).
Length = 285
Score = 60.9 bits (141), Expect = 2e-08
Identities = 51/253 (20%), Positives = 117/253 (46%), Gaps = 13/253 (5%)
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
D E + + S + E++ ++++L + ELD E K+ ++ E +
Sbjct: 21 DRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAA 80
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFAD-------VAVNT---DED 915
+ + + A L + +E+++ +E++ T Q +E K AD V N DE+
Sbjct: 81 DAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEE 140
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L + + + AE E +++ + +L + DL+ T + + A K ++ ++E +
Sbjct: 141 KMELQEIQLKEAKHIAE-EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 199
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSN 1034
L+ +A+ E+ Q+ + +EE + + LK+ E + + + + LE +D L +
Sbjct: 200 NVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLED 259
Query: 1035 QKVALEKQIESLS 1047
+ A + + +++S
Sbjct: 260 ELYAQKLKYKAIS 272
Score = 58.0 bits (134), Expect = 2e-07
Identities = 56/233 (24%), Positives = 101/233 (43%), Gaps = 9/233 (3%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KLD + +++E Q +ER + EL ++++ K +DE + +E L++ E+
Sbjct: 13 KLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKL 72
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+K+ E +V++L +I Q VE + A + T D +
Sbjct: 73 ELAEKKAADAEAEVASLNRRI---QLVEEELDRAQERLATALQKLEEAEKAADESERGMK 129
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
V +N R +K E++ ++ LK ++A KY + ++ +LE + E +
Sbjct: 130 VIEN-RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAE 188
Query: 993 QRYKELDEECETCAEYLKQREEQCKRL--KEAKIALEI---VDKLSNQKVALE 1040
+ EL+EE + LK E Q ++ KE K EI DKL + E
Sbjct: 189 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAE 241
Score = 35.9 bits (79), Expect = 0.80
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 24/236 (10%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV---- 168
K LE E K++K D L S+ + + QE+ + + E +LN+ +
Sbjct: 38 KQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVE 97
Query: 169 DDLKKNNECLT---QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
++L + E L QK + EK +ESE G K I + E ++ I +K
Sbjct: 98 EELDRAQERLATALQKLEEAEKAADESER--GMKVIENRALKDEEKMELQEIQLKE--AK 153
Query: 226 LNRSISDSNTSTRYNKICTLQSELDAGRE-------DCKELCEDFTSIKNHLELHEPNMT 278
+D K+ ++ +L+ E C EL E+ ++ N+L+ E
Sbjct: 154 HIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQA- 212
Query: 279 MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
EK + + + +K++++ + + +E + +K K ID +D L A
Sbjct: 213 ----EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKT-IDDLEDELYA 263
Score = 33.1 bits (72), Expect = 5.7
Identities = 30/165 (18%), Positives = 65/165 (39%), Gaps = 1/165 (0%)
Query: 607 REKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
R K+ + EL + +K ELDK + E SL +
Sbjct: 36 RSKQLE-DELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQ 94
Query: 667 ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
++E+ + + ++ EK A+ R + ++ + +D++ +E +L E +
Sbjct: 95 LVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 154
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
E R Y+ + L + + + +L E + +ELE +++
Sbjct: 155 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 199
Score = 32.3 bits (70), Expect = 9.9
Identities = 47/218 (21%), Positives = 89/218 (40%), Gaps = 21/218 (9%)
Query: 246 QSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRN 305
Q +L+ + + + S+ ++L E + E+L + +A K E +R
Sbjct: 69 QEKLELAEKKAADAEAEVASLNRRIQLVEEELDR-AQERLATALQKLEEAEKAADESERG 127
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE 365
+ + + + +E K I + K++ +A+ + ++++ DL+
Sbjct: 128 MKVIENRALKDEEKMELQEI-QLKEAKHIAEEADRKYEEVARKLVIIEG-------DLER 179
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
E+ + +E ELK+V L SL +Q EK + QKE +E + D
Sbjct: 180 TEERAELAESKCSELEEELKNVTNNLKSLEAQ-AEKYS-------QKEDKYEEEIKILTD 231
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK 463
+K+ E + KL K ID DL+ +L A K
Sbjct: 232 KLKEAETRAEFAERSVAKLEK-TID---DLEDELYAQK 265
>D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein.
Length = 2067
Score = 60.9 bits (141), Expect = 2e-08
Identities = 143/735 (19%), Positives = 292/735 (39%), Gaps = 63/735 (8%)
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+IK+ K + + L T R L+ Q+ ++ N KD+EI+ L L+ K+ NE
Sbjct: 1237 NIKKNKGVKDWPWWKLF--TTVRPLIEVQLSEEQIRN--KDEEIQQLRSKLEKAEKERNE 1292
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L+ +D L + I E +E + + + + T + + EK + E + + +
Sbjct: 1293 LRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDA--LK 1350
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSELDAGREDCKELCE 261
Q ++ E + + +++N + D + + K E+D ++ ++ E
Sbjct: 1351 KQMEVMEMEVMEARL---IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1407
Query: 262 DFTSI----KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK-RNLNSLSEQLINN 316
D + K LE ++ D +E + + K ++ +E++ L+ +Q+ N+
Sbjct: 1408 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH 1467
Query: 317 ESKK---------------------SKDHIDRYKDSLLA---VLDAEFGTTSLDVFEILM 352
E +K ++ + R KD LLA L + +D+
Sbjct: 1468 ELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ 1527
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + +L +I + +K + L + +L+ + K+ +L E+ +L K
Sbjct: 1528 K--VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1585
Query: 413 ERI----HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
R+ + + ++ ++ E++E KL ++++ + + + ++ L
Sbjct: 1586 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1645
Query: 469 FDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L T +++R D+E EK +LR + KA+ + E ++K+
Sbjct: 1646 EGKLATLSDQVNRRDFESEK-RLRKDLKRTKALLADAQLMLDHLKNSAPSKREI-AQLKN 1703
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
EE + V A I+ L +ID + A EE++ L + N E+ +
Sbjct: 1704 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN---EIQNR 1760
Query: 588 INGLKEENNSLKSLNDVITREKE---TQASELERSCQVIKQNGFEL-DKMKADILMXXXX 643
+ +E+ N L + + Q ++L+ + + EL +K++A
Sbjct: 1761 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL 1820
Query: 644 XXXXXXXXXXXXDEAK-SLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
EAK LE L + Q + SRL+ N+ EK E +++ I
Sbjct: 1821 EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENM---EKLTEERDQRIA 1877
Query: 702 RLQKQIQEDDKLFIE-KETK--LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
++ +++ +L + ++TK + EL K R DLES A L L
Sbjct: 1878 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL 1937
Query: 759 VEGRIAELESDIRTE 773
RI +L++ I E
Sbjct: 1938 AFKRIGDLQAAIEDE 1952
Score = 58.4 bits (135), Expect = 1e-07
Identities = 91/407 (22%), Positives = 167/407 (41%), Gaps = 31/407 (7%)
Query: 656 DEAKSLLEQNLALKEQCEEKTR-DCSRLEINIK--THEKTAEIQNRMIMRLQKQIQEDDK 712
DE L L E+ + R + RLE I T E T E + ++
Sbjct: 1273 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 1332
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSR----EAVNQLTTQKDLVEGRIAELES 768
L EKE K EL +Y+ALK+ + ++ +R +N D + E
Sbjct: 1333 LRAEKEMK--ELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYER 1390
Query: 769 DIR-TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+R + T GD D E+ + K+ ++
Sbjct: 1391 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT- 1449
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ K L Q +L+++ + D E E Q Q +L++EK L +
Sbjct: 1450 AELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAF 1509
Query: 888 NLKEQIR---------TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+LK+Q+ TQ+ V +A+ D++ +D A+L V +A+V+ +
Sbjct: 1510 SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE- 1568
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELE-ELKQRYK 996
+ ++E Q L+ +++ ME+ + KE E++ +E+E+ + + +LKQ
Sbjct: 1569 --EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1626
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+L+EE E KQ+ + KR E K+A + D+++ + EK++
Sbjct: 1627 QLEEEYED-----KQKVLREKRELEGKLA-TLSDQVNRRDFESEKRL 1667
Score = 53.2 bits (122), Expect = 5e-06
Identities = 129/681 (18%), Positives = 272/681 (39%), Gaps = 46/681 (6%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
+ K + + +E+ +++ ++E TSEL S SQL++ E A LR +KE +
Sbjct: 1283 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA-SQLLDAETA-ERLRAEKE-M 1339
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ 475
E+ + D +KK+ E+ E+ E + +I+ ++D D A + + ++ + +
Sbjct: 1340 KELQTQY--DALKKQMEVMEMEVMEARLIRAAEIN--GEVDDD-DAGGEWRLKYERAVRE 1394
Query: 476 YELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL-- 532
+ ++ + E ++KL +E + + L++ + + L EL
Sbjct: 1395 VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 1454
Query: 533 TKLYKSKVDENNANLNL--------IKILSEEIDALKIAIAK-NEEKMLSLSEK---DNK 580
TKL+ N L + EE K+ K EK + L+E +
Sbjct: 1455 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1514
Query: 581 LTELVSTINGLKEENNSLKS-LNDVITREKETQASELERSCQV------IKQNGFELDKM 633
L E I G ++ SL++ L D+ ++E + +AS + Q+ +K ELD+
Sbjct: 1515 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1574
Query: 634 KADILMXXXXXXXXXXXXX----XXXDEAKSLLEQNLALKEQCEEKTRDCS-RLEINIKT 688
I M E +S E+ ++ C++K + +LE +
Sbjct: 1575 AGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1634
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
+K + + +L + ++ E E +L + + +AL D + L++S +
Sbjct: 1635 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS 1694
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
++ K+ +E + ++ + V R+
Sbjct: 1695 KREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREK 1754
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E + + ++ + + + + Q ++DL+ + +E + E + E LQ
Sbjct: 1755 NEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ-INDLQAQLEEANKEKQELQEKLQAL 1813
Query: 869 DEQCARLKK---EKLSLEQQVSNLKEQIRTQQPVER-QAK-FADVAVNTDEDWANLHSVV 923
Q L++ +K + +Q + ++E + T+ ER Q K +A E+ L
Sbjct: 1814 QSQVEFLEQSMVDKSLVSRQEAKIRE-LETRLEFERTQVKRLESLASRLKENMEKLTEER 1872
Query: 924 VDRMSYD-AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R++ + E E+NKRL + +LR K+++ K +A K + + + E+ +
Sbjct: 1873 DQRIAAENREKEQNKRLQR---QLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQ 1929
Query: 983 DCKAELEELKQRYKELDEECE 1003
+A+L+ +R +L E
Sbjct: 1930 SLQADLKLAFKRIGDLQAAIE 1950
Score = 51.2 bits (117), Expect = 2e-05
Identities = 74/292 (25%), Positives = 130/292 (44%), Gaps = 38/292 (13%)
Query: 827 DSEVSQLKERLLSCQQELDDLK-----------ERYKELDDECETCAEYLQERDEQCA-- 873
D E+ QL+ +L ++E ++L+ E EL DE T Q D + A
Sbjct: 1273 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 1332
Query: 874 -RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VN---TDEDWANLHSVVVDRMS 928
R +KE L+ Q LK+Q+ + +A+ A +N D+D + +R
Sbjct: 1333 LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAV 1392
Query: 929 YDAEVEKNKRLMKTIE-----ELRYKKQ------DLKNTVTKMQKAMEKYTKKDKEFEAK 977
+ + K KRL + E E + K+Q DL+ + Q+A+++ KK + A
Sbjct: 1393 REVDFTK-KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA- 1450
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR--LKEAKIALEIVDKLSNQ 1035
EL+D K LE + R EL+++ L Q E+ +R L+ K+ E D L +
Sbjct: 1451 --ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE-KDMLLAE 1507
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+L++Q+E + ++ T V + A +Q+ + K+ L K+ +L
Sbjct: 1508 AFSLKQQLEE-KDMDIAGFTQKVVSLEAELQDIS-SQESKDEASLAKVKKQL 1557
Score = 49.2 bits (112), Expect = 8e-05
Identities = 104/526 (19%), Positives = 208/526 (39%), Gaps = 38/526 (7%)
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
L++ R K+ + +L + ++ EL ++ +D L E+ S
Sbjct: 1264 LSEEQIRNKDEEIQQLRSKLEKAEKERNEL-RLNSDRLESRISELTSELTDERNTGESAS 1322
Query: 661 -LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
LL+ A + + E++ ++ L+ +K E+ +M + + ++ +
Sbjct: 1323 QLLDAETAERLRAEKEMKE---LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDD 1379
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVEGRIAELESDIRTEQTATV 778
E KYE R+ D K L+ E ++ Q K +E R+ +L++D +E++
Sbjct: 1380 AGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQAD--SEESQRA 1437
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
G + R N +L+ +R DSE+SQ E
Sbjct: 1438 LQQLKKKCQRLTAELQDTKLHLEGQQVR----NHELEKKQRRF-----DSELSQAHEEAQ 1488
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ- 897
+ + + L+ L E + + L+E+D A ++ +SLE ++ ++ Q +
Sbjct: 1489 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1548
Query: 898 ---PVERQ-----AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRY 948
V++Q AK D DE + + ++ + E+E+ ++ K +E
Sbjct: 1549 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1608
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
+ ++ + + K K ME + ++E+E K+K L + K ELE D+ E
Sbjct: 1609 EVEEARQSCQKKLKQME--VQLEEEYEDKQKVLRE-KRELEGKLATLS--DQVNRRDFES 1663
Query: 1009 LKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESLSN-TPVSNSTMYVATGSAIVQ 1066
K+ + KR K ++ +D L N + +++I L N S T A +
Sbjct: 1664 EKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVKARKAM 1722
Query: 1067 NQQITDVMKENQKLKKMNAKL---ITICKKRGKTGANRENEDPSDV 1109
+I D+ + + K L ++ ++ NR ED D+
Sbjct: 1723 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM 1768
Score = 48.4 bits (110), Expect = 1e-04
Identities = 98/493 (19%), Positives = 218/493 (44%), Gaps = 59/493 (11%)
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEIN-----IKTHEKTAEIQNRMIMRL------- 703
+E++ L+Q LK++C+ T + +++ ++ HE + Q R L
Sbjct: 1432 EESQRALQQ---LKKKCQRLTAELQDTKLHLEGQQVRNHELEKK-QRRFDSELSQAHEEA 1487
Query: 704 QKQIQEDDKLFIEKETKLNELTN-KYEALKRDYDAA--VKDLESSREAVNQLTTQKDLVE 760
Q++ + +KL EK+ L E + K + ++D D A + + S + +++Q+ E
Sbjct: 1488 QREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE 1547
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLDDSPK 819
+A+++ +R + E + + + K +S
Sbjct: 1548 ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD 1607
Query: 820 RSISVISDSEVSQLKERLLSCQQELDD----LKERYKELDDECETCAEYLQERD-EQCAR 874
+ S +LK+ + ++E +D L+E+ +EL+ + T ++ + RD E R
Sbjct: 1608 EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK-RELEGKLATLSDQVNRRDFESEKR 1666
Query: 875 LKKEKLSLEQQVSNLK---EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+K+ + +++ + + ++ P +R+ A + +E + V R + +
Sbjct: 1667 LRKDLKRTKALLADAQLMLDHLKNSAPSKRE--IAQLKNQLEESEFTCAAAVKARKAMEV 1724
Query: 932 EVE----------KNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK- 979
E+E K K L + + L+ +K +++N + + Q+ M + KK K A+
Sbjct: 1725 EIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASR 1784
Query: 980 ---ELEDCKAELEELKQRYKELDEECETC---AEYLKQR--EEQCKRLKEAKIALEIVDK 1031
++ D +A+LEE + +EL E+ + E+L+Q ++ +EAKI E+ +
Sbjct: 1785 DLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR-ELETR 1843
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITIC 1091
L ++ + K++ESL++ N ++Q+I +E ++ K++ +L
Sbjct: 1844 LEFERTQV-KRLESLASRLKENMEKLTEE-----RDQRIAAENREKEQNKRLQRQLRDTK 1897
Query: 1092 KKRGKTGANRENE 1104
++ G+ A +E E
Sbjct: 1898 EEMGEL-ARKEAE 1909
Score = 46.8 bits (106), Expect = 4e-04
Identities = 80/415 (19%), Positives = 182/415 (43%), Gaps = 56/415 (13%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLL--------MSQI 112
QS ++ ++ ++LE+ + + +K LEGK L + RD + +
Sbjct: 1615 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT 1674
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN---VTESDNLNKEVD 169
K+L + +KN S + ++ N+L+E T + + E ++L+ ++D
Sbjct: 1675 KALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID 1734
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS 229
D+ K L ++ L++ NE +N++ +E++ N L K +++
Sbjct: 1735 DIAKAKTALEEQLSRLQREKNEIQNRLEED--------QEDM---------NELMKKHKA 1777
Query: 230 ISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN 289
+ + S +I LQ++L+ ++ +EL E ++++ +E E +M +D+ L
Sbjct: 1778 -AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSM---VDKSLVSRQ 1833
Query: 290 EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
E + + ++ E +R E L + K++ + + +D +A + E
Sbjct: 1834 EAKIRELETRLEFERTQVKRLESLA-SRLKENMEKLTEERDQRIAAENREKEQNK----- 1887
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
+ + + ++ E+ K + +E +L+S+ SL + L+
Sbjct: 1888 -RLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQAD----------LK 1936
Query: 410 IQKERIHEISSAVTIDIVKKENE-----LKEILTKECLKLSKLKIDIPRDLDQDL 459
+ +RI ++ +A+ ++ ENE L++++TK + +KL+ D D+D +L
Sbjct: 1937 LAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGD--SDVDSEL 1989
Score = 40.3 bits (90), Expect = 0.037
Identities = 106/585 (18%), Positives = 249/585 (42%), Gaps = 44/585 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI-KSLEMENLTKDKEIK 127
++ K ++L+ EL D K + + L + + D +SQ + + E L ++K ++
Sbjct: 1440 QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK-LQ 1498
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC----LTQKCI 183
D L ++ + + EE D + V + +++ + +E + ++
Sbjct: 1499 REKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1558
Query: 184 DLEKLVNESENKI----GPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
DLE V + E ++ G + Q KL+ E ++ + + + + + ++ S +
Sbjct: 1559 DLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQ 1618
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K+ ++ +L+ ED +++ + K LE ++ ++ + E+ + K +K
Sbjct: 1619 -KKLKQMEVQLEEEYEDKQKVLRE----KRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1673
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ + + + L N S SK I + K+ L ++EF + M+ I
Sbjct: 1674 TKALLADAQLMLDHLKN--SAPSKREIAQLKNQL---EESEFTCAAAVKARKAMEVEIED 1728
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE--KENACNILRIQKE--R 414
+ +D+I + T ++ L+ E + +L + E K++ + + ++ +
Sbjct: 1729 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1788
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
I+++ + + + K++ EL+E L + L+ S+++ +D+ L + ++ I L T
Sbjct: 1789 INDLQAQLE-EANKEKQELQEKL--QALQ-SQVEFLEQSMVDKSLVSRQEAKI--RELET 1842
Query: 475 QYELSRTDYE-IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
+ E RT + +E RL+ K + + + +++ EE+
Sbjct: 1843 RLEFERTQVKRLESLASRLKENMEK-LTEERDQRIAAENREKEQNKRLQRQLRDTKEEMG 1901
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+L + + + + L E+D L+ A N+ L ++ +L + I E
Sbjct: 1902 ELARKEAEASRKKHEL------EMD-LESLEAANQSLQADLKLAFKRIGDLQAAIEDEME 1954
Query: 594 --ENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
EN L SL D++T+ ++ + ++LE V + +D +K+
Sbjct: 1955 SDENEDLINSLQDMVTKYQK-RKNKLEGDSDVDSELEDRVDGVKS 1998
Score = 33.1 bits (72), Expect = 5.7
Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 933 VEKNKRLMKTIEELRYKKQ-DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
V+KN + K +++ + K + ++Q + E+ KD+E + R +LE + E EL
Sbjct: 1234 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNEL 1293
Query: 992 KQRYKELDEE-CETCAEYLKQRE--EQCKRLKEAKIALEI-----VDKLSNQKVALEKQI 1043
+ L+ E +E +R E +L +A+ A + + +L Q AL+KQ+
Sbjct: 1294 RLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM 1353
Query: 1044 E 1044
E
Sbjct: 1354 E 1354
>BC117174-1|AAI17175.1| 1291|Homo sapiens KIF15 protein protein.
Length = 1291
Score = 60.9 bits (141), Expect = 2e-08
Identities = 165/868 (19%), Positives = 347/868 (39%), Gaps = 93/868 (10%)
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+NT ++ +Q+EL+ +++ +E E + K LEL ++ EN
Sbjct: 482 ANTEKLKAQLLQIQTELNNSKQEYEEFKE--LTRKRQLELESELQSLQKANLNLENLLEA 539
Query: 293 TKAVKVMSEIKRN-LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL 351
TKA K + N +++ + ++I +K + H R L + + FG+ IL
Sbjct: 540 TKACKRQEVSQLNKIHAETLKIITTPTKAYQLH-SRPVPKLSPEMGS-FGSLYTQNSSIL 597
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
++I+N+ + + + + + +L ++ ++ KL + ++ + + L
Sbjct: 598 DNDILNE-PVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHH 656
Query: 412 KERIHEISSAVTIDIVKKENELKEILT--KECLKLSKLKIDIPRDLDQDLPAHKKITILF 469
++ E+ S+ ID K++ EL L ++ L+ ++ K D + DL + +
Sbjct: 657 STQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDL---RVVLHSA 713
Query: 470 DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVK--- 526
D ++ +L + ++ +EK F+ L E H V+
Sbjct: 714 DKELSSVKLEYSSFKTNQEK------------------------EFNKLSERHMHVQLQL 749
Query: 527 -SLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELV 585
+L E KL +SK ++ NL +I+ EID L + +++ +L N L EL
Sbjct: 750 DNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMEL- 808
Query: 586 STINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXX 645
+ KE NN L SL +KE + E+ + + ++Q +K K
Sbjct: 809 --LEAEKERNNKL-SLQ--FEEDKENSSKEILKVLEAVRQ-----EKQK----------- 847
Query: 646 XXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQK 705
+ AK EQ +A ++ EE ++ I + EK+ + +++ L
Sbjct: 848 ----------ETAKC--EQQMAKVQKLEESLLATEKV---ISSLEKSRDSDKKVVADLMN 892
Query: 706 QIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV-NQLTTQKDLVEG-RI 763
QIQE EK ++ L + + + Y++A+ D E SR + Q DL E R+
Sbjct: 893 QIQELRSSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRL 952
Query: 764 AELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
L DI + +L + L + ++
Sbjct: 953 RILSEDIERDMLCE-DLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLN 1011
Query: 824 VISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLE 883
EV Q K ++L+ + + E D + + Q + +++++
Sbjct: 1012 Q-KKEEVEQKKNEYNFKMRQLEHVMDSAAE-DPQSPKTPPHFQTHLAKLLETQEQEIEDG 1069
Query: 884 QQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTI 943
+ E + T+ +R+ K A++ + E + ++ R+ +EKN L +
Sbjct: 1070 RASKTSLEHLVTKLNEDREVKNAEI-LRMKEQLREMENL---RLESQQLIEKNWLLQGQL 1125
Query: 944 EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELED---CKAELEELKQRYKELDE 1000
++++ +K++ Q+ + + KE AK K +E+ KA+LEE++ +
Sbjct: 1126 DDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEM 1185
Query: 1001 ECETCAEYLKQREE-QCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
EC + +++ + + K +E + ++++ ++ +++E L
Sbjct: 1186 ECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLR----KQVECLAE 1241
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+V +Q + ++ +LKK N +L
Sbjct: 1242 ENGKLVGHQNLHQKIQYVVRLKKENVRL 1269
Score = 47.6 bits (108), Expect = 2e-04
Identities = 134/662 (20%), Positives = 271/662 (40%), Gaps = 54/662 (8%)
Query: 75 EKLSGELFDIKEQKSALEGK-----YQNLILETQTRDLLMSQIKSLEM---ENLTKDKEI 126
E +S EL ++EQ SAL+ K ++NL L+ L + E+ E + K+
Sbjct: 616 EAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQ 675
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+ L L K++ E Q +ND L + + + + +KE+ +K
Sbjct: 676 EELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSF-------- 727
Query: 187 KLVNESE-NKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
K E E NK+ +++ Q +L +++ + + + L S + ++ +I L
Sbjct: 728 KTNQEKEFNKLSERHMHVQLQLDNLRLENEKL--LESKACLQDSYDNLQEIMKF-EIDQL 784
Query: 246 QSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAV-KVMSEIKR 304
L +++ + L D ++ LE E L + E+ E +K + KV+ +++
Sbjct: 785 SRNLQNFKKENETLKSDLNNLMELLEA-EKERNNKLSLQFEEDKENSSKEILKVLEAVRQ 843
Query: 305 NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLD 364
++ E + +K + + ++SLLA E +SL+ ++ +
Sbjct: 844 ---EKQKETAKCEQQMAK--VQKLEESLLA---TEKVISSLEKSRDSDKKVVADLMNQIQ 895
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
E+ + ++ ELK +N K NS L+++E + +++ Q+ I ++ + +
Sbjct: 896 ELRSSVCEKTETIDTLKQELKDINCK---YNSALVDREESRVLIKKQEVDILDLKETLRL 952
Query: 425 DIVKKENE---LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI--TQYELS 479
I+ ++ E L E L +L+ L + A +++T +ALI Q++L+
Sbjct: 953 RILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELT-KKEALIQELQHKLN 1011
Query: 480 RTDYEIEKEK--LRLETGTAKAVXXXXXXXXXXXXX--XFDTLEEAHNEVKSLHEELTKL 535
+ E+E++K + + V F T E + E +
Sbjct: 1012 QKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRA 1071
Query: 536 YKSKVDENNANLNLIK-ILSEEIDALKIAIAKNEEKML---SLSEKDNKLTELVSTINGL 591
K+ ++ LN + + + EI +K + + E L L EK+ L + I
Sbjct: 1072 SKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQ 1131
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
KE ++ N + E+E E ++++ E+ KMKAD+
Sbjct: 1132 KENSDQNHPDNQQLKNEQEESIKERLAKSKIVE----EMLKMKADLEEVQSALYNKEMEC 1187
Query: 652 XXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
DE + Q L K +EK + S+LE + E+T++ + +++ +E+
Sbjct: 1188 LRMTDEVER--TQTLESK-AFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENG 1244
Query: 712 KL 713
KL
Sbjct: 1245 KL 1246
Score = 47.6 bits (108), Expect = 2e-04
Identities = 58/277 (20%), Positives = 118/277 (42%), Gaps = 21/277 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKE---SSNEINLKLEKLSGEL 81
N L A K+ ++++ + +++ + K+ Q +E NE N K+ +L +
Sbjct: 976 NMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVM 1035
Query: 82 FDIKE--QKSALEGKYQN---LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTK 136
E Q +Q +LETQ +++ + +E+L + L + + K
Sbjct: 1036 DSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHL-----VTKLNEDREVK 1090
Query: 137 SKKINELQEENDTLSNLIMEN---VTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESE 193
+ +I ++E+ + NL +E+ + ++ L ++DD+K+ E Q D ++L NE E
Sbjct: 1091 NAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQE 1150
Query: 194 NKIGPKNICAQCKLKENLIQSLHIGYDNTLSKL-NRSISDSNTSTRYNKICTLQSELDAG 252
I K A+ K+ E +++ + + S L N+ + + + TL+S+
Sbjct: 1151 ESI--KERLAKSKIVEEMLK-MKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQE 1207
Query: 253 REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN 289
+E + E+ + E M E L E N
Sbjct: 1208 KEQLRSKLEEMYEERERTS-QEMEMLRKQVECLAEEN 1243
Score = 42.7 bits (96), Expect = 0.007
Identities = 138/695 (19%), Positives = 280/695 (40%), Gaps = 80/695 (11%)
Query: 358 KYQIDLDEILEKYTKVQ----GDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
K Q +D++ T++Q + + T + + + +L L QL E + + L+ +
Sbjct: 645 KLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVH 704
Query: 414 RIHEI--SSAVTIDIVKKE-NELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFD 470
+ + S+ + VK E + K KE KLS+ + + LD ++K+
Sbjct: 705 DLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKA 764
Query: 471 ALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHE 530
L Y+ + + E ++L K + +E +N++ E
Sbjct: 765 CLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFE 824
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
E D+ N++ ++K+L + AK E++M + + + L I+
Sbjct: 825 E---------DKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISS 875
Query: 591 LKEENNSLKSL-NDVITREKETQASELERS--CQVIKQNGFELD-KMKADILMXXXXXXX 646
L++ +S K + D++ + +E ++S E++ +KQ +++ K + ++
Sbjct: 876 LEKSRDSDKKVVADLMNQIQELRSSVCEKTETIDTLKQELKDINCKYNSALVDREESRVL 935
Query: 647 XXXXXXXXXDEAKSL----LEQNLALKEQCEE---KTRDCSRLEINIKTHEKTAEIQNRM 699
D ++L L +++ CE+ T + L K H +
Sbjct: 936 IKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEE 995
Query: 700 IMRLQKQIQE-DDKLFIEKET---KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
+ + + IQE KL +KE K NE K L+ D+A +D +S + + T
Sbjct: 996 LTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHL 1055
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
L+E + E+E D R +T+ ++ R++ EN +L
Sbjct: 1056 AKLLETQEQEIE-DGRASKTS---LEHLVTKLNEDREVKNAEILRMKEQLREM-ENLRL- 1109
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
E QL E+ Q +LDD+K R KE D+ D Q +L
Sbjct: 1110 -------------ESQQLIEKNWLLQGQLDDIK-RQKENSDQ--------NHPDNQ--QL 1145
Query: 876 KKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
K E Q ++KE++ + VE K + + +E + L++ ++ + EVE+
Sbjct: 1146 KNE------QEESIKERLAKSKIVEEMLK---MKADLEEVQSALYNKEMECLRMTDEVER 1196
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRY 995
+T+E + Q+ + +K+++ E+ + +E E RK++E C AE +
Sbjct: 1197 T----QTLESKAF--QEKEQLRSKLEEMYEERERTSQEMEMLRKQVE-CLAEENGKLVGH 1249
Query: 996 KELDEECETCAEYLKQR---EEQCKRLKEAKIALE 1027
+ L ++ + K+ E+ ++L+ + L+
Sbjct: 1250 QNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLK 1284
Score = 35.1 bits (77), Expect = 1.4
Identities = 48/232 (20%), Positives = 97/232 (41%), Gaps = 16/232 (6%)
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLK 876
SPK + +LK +LL Q EL++ K+ Y+E E + E + + L+
Sbjct: 471 SPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFK---ELTRKRQLELESELQSLQ 527
Query: 877 KEKLSLEQQVSNLKEQIRTQQPVERQAKFADV--AVNTDEDWANLHSVVVDRMSYDAEVE 934
K L+LE + K + Q+ + A+ + T LHS V ++S E+
Sbjct: 528 KANLNLENLLEATK-ACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLS--PEMG 584
Query: 935 KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQR 994
L + D+ N + + + +E ++++ +A+L+E + +
Sbjct: 585 SFGSLY--TQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHK 642
Query: 995 YKELDEECETCAEYLKQREE--QCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+L + + + Q +E +R+ K E++ +L+ LEKQ++
Sbjct: 643 NLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN----VLEKQLQ 690
>BC008425-1|AAH08425.1| 285|Homo sapiens tropomyosin 3 protein.
Length = 285
Score = 60.9 bits (141), Expect = 2e-08
Identities = 51/253 (20%), Positives = 117/253 (46%), Gaps = 13/253 (5%)
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
D E + + S + E++ ++++L + ELD E K+ ++ E +
Sbjct: 21 DRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAA 80
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFAD-------VAVNT---DED 915
+ + + A L + +E+++ +E++ T Q +E K AD V N DE+
Sbjct: 81 DAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEE 140
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L + + + AE E +++ + +L + DL+ T + + A K ++ ++E +
Sbjct: 141 KMELQEIQLKEAKHIAE-EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 199
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSN 1034
L+ +A+ E+ Q+ + +EE + + LK+ E + + + + LE +D L +
Sbjct: 200 NVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLED 259
Query: 1035 QKVALEKQIESLS 1047
+ A + + +++S
Sbjct: 260 ELYAQKLKYKAIS 272
Score = 58.0 bits (134), Expect = 2e-07
Identities = 56/233 (24%), Positives = 101/233 (43%), Gaps = 9/233 (3%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KLD + +++E Q +ER + EL ++++ K +DE + +E L++ E+
Sbjct: 13 KLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKL 72
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+K+ E +V++L +I Q VE + A + T D +
Sbjct: 73 ELAEKKAADAEAEVASLNRRI---QLVEEELDRAQERLATALQKLEEAEKAADESERGMK 129
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
V +N R +K E++ ++ LK ++A KY + ++ +LE + E +
Sbjct: 130 VIEN-RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAE 188
Query: 993 QRYKELDEECETCAEYLKQREEQCKRL--KEAKIALEI---VDKLSNQKVALE 1040
+ EL+EE + LK E Q ++ KE K EI DKL + E
Sbjct: 189 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAE 241
Score = 35.9 bits (79), Expect = 0.80
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 24/236 (10%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV---- 168
K LE E K++K D L S+ + + QE+ + + E +LN+ +
Sbjct: 38 KQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVE 97
Query: 169 DDLKKNNECLT---QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
++L + E L QK + EK +ESE G K I + E ++ I +K
Sbjct: 98 EELDRAQERLATALQKLEEAEKAADESER--GMKVIENRALKDEEKMELQEIQLKE--AK 153
Query: 226 LNRSISDSNTSTRYNKICTLQSELDAGRE-------DCKELCEDFTSIKNHLELHEPNMT 278
+D K+ ++ +L+ E C EL E+ ++ N+L+ E
Sbjct: 154 HIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQA- 212
Query: 279 MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
EK + + + +K++++ + + +E + +K K ID +D L A
Sbjct: 213 ----EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKT-IDDLEDELYA 263
Score = 33.1 bits (72), Expect = 5.7
Identities = 30/165 (18%), Positives = 65/165 (39%), Gaps = 1/165 (0%)
Query: 607 REKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
R K+ + EL + +K ELDK + E SL +
Sbjct: 36 RSKQLE-DELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQ 94
Query: 667 ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
++E+ + + ++ EK A+ R + ++ + +D++ +E +L E +
Sbjct: 95 LVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 154
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
E R Y+ + L + + + +L E + +ELE +++
Sbjct: 155 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 199
Score = 32.3 bits (70), Expect = 9.9
Identities = 47/218 (21%), Positives = 89/218 (40%), Gaps = 21/218 (9%)
Query: 246 QSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRN 305
Q +L+ + + + S+ ++L E + E+L + +A K E +R
Sbjct: 69 QEKLELAEKKAADAEAEVASLNRRIQLVEEELDR-AQERLATALQKLEEAEKAADESERG 127
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE 365
+ + + + +E K I + K++ +A+ + ++++ DL+
Sbjct: 128 MKVIENRALKDEEKMELQEI-QLKEAKHIAEEADRKYEEVARKLVIIEG-------DLER 179
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
E+ + +E ELK+V L SL +Q EK + QKE +E + D
Sbjct: 180 TEERAELAESKCSELEEELKNVTNNLKSLEAQ-AEKYS-------QKEDKYEEEIKILTD 231
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK 463
+K+ E + KL K ID DL+ +L A K
Sbjct: 232 KLKEAETRAEFAERSVAKLEK-TID---DLEDELYAQK 265
>BC008407-1|AAH08407.1| 285|Homo sapiens tropomyosin 3 protein.
Length = 285
Score = 60.9 bits (141), Expect = 2e-08
Identities = 51/253 (20%), Positives = 117/253 (46%), Gaps = 13/253 (5%)
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
D E + + S + E++ ++++L + ELD E K+ ++ E +
Sbjct: 21 DRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAA 80
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFAD-------VAVNT---DED 915
+ + + A L + +E+++ +E++ T Q +E K AD V N DE+
Sbjct: 81 DAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEE 140
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L + + + AE E +++ + +L + DL+ T + + A K ++ ++E +
Sbjct: 141 KMELQEIQLKEAKHIAE-EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 199
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSN 1034
L+ +A+ E+ Q+ + +EE + + LK+ E + + + + LE +D L +
Sbjct: 200 NVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLED 259
Query: 1035 QKVALEKQIESLS 1047
+ A + + +++S
Sbjct: 260 ELYAQKLKYKAIS 272
Score = 58.0 bits (134), Expect = 2e-07
Identities = 56/233 (24%), Positives = 101/233 (43%), Gaps = 9/233 (3%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KLD + +++E Q +ER + EL ++++ K +DE + +E L++ E+
Sbjct: 13 KLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKL 72
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+K+ E +V++L +I Q VE + A + T D +
Sbjct: 73 ELAEKKAADAEAEVASLNRRI---QLVEEELDRAQERLATALQKLEEAEKAADESERGMK 129
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
V +N R +K E++ ++ LK ++A KY + ++ +LE + E +
Sbjct: 130 VIEN-RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAE 188
Query: 993 QRYKELDEECETCAEYLKQREEQCKRL--KEAKIALEI---VDKLSNQKVALE 1040
+ EL+EE + LK E Q ++ KE K EI DKL + E
Sbjct: 189 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAE 241
Score = 35.9 bits (79), Expect = 0.80
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 24/236 (10%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV---- 168
K LE E K++K D L S+ + + QE+ + + E +LN+ +
Sbjct: 38 KQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVE 97
Query: 169 DDLKKNNECLT---QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
++L + E L QK + EK +ESE G K I + E ++ I +K
Sbjct: 98 EELDRAQERLATALQKLEEAEKAADESER--GMKVIENRALKDEEKMELQEIQLKE--AK 153
Query: 226 LNRSISDSNTSTRYNKICTLQSELDAGRE-------DCKELCEDFTSIKNHLELHEPNMT 278
+D K+ ++ +L+ E C EL E+ ++ N+L+ E
Sbjct: 154 HIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQA- 212
Query: 279 MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
EK + + + +K++++ + + +E + +K K ID +D L A
Sbjct: 213 ----EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKT-IDDLEDELYA 263
Score = 33.1 bits (72), Expect = 5.7
Identities = 30/165 (18%), Positives = 65/165 (39%), Gaps = 1/165 (0%)
Query: 607 REKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
R K+ + EL + +K ELDK + E SL +
Sbjct: 36 RSKQLE-DELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQ 94
Query: 667 ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
++E+ + + ++ EK A+ R + ++ + +D++ +E +L E +
Sbjct: 95 LVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 154
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
E R Y+ + L + + + +L E + +ELE +++
Sbjct: 155 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 199
Score = 32.3 bits (70), Expect = 9.9
Identities = 47/218 (21%), Positives = 89/218 (40%), Gaps = 21/218 (9%)
Query: 246 QSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRN 305
Q +L+ + + + S+ ++L E + E+L + +A K E +R
Sbjct: 69 QEKLELAEKKAADAEAEVASLNRRIQLVEEELDR-AQERLATALQKLEEAEKAADESERG 127
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE 365
+ + + + +E K I + K++ +A+ + ++++ DL+
Sbjct: 128 MKVIENRALKDEEKMELQEI-QLKEAKHIAEEADRKYEEVARKLVIIEG-------DLER 179
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
E+ + +E ELK+V L SL +Q EK + QKE +E + D
Sbjct: 180 TEERAELAESKCSELEEELKNVTNNLKSLEAQ-AEKYS-------QKEDKYEEEIKILTD 231
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK 463
+K+ E + KL K ID DL+ +L A K
Sbjct: 232 KLKEAETRAEFAERSVAKLEK-TID---DLEDELYAQK 265
>AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit
SP-R210 alphaS protein.
Length = 1581
Score = 60.9 bits (141), Expect = 2e-08
Identities = 143/735 (19%), Positives = 292/735 (39%), Gaps = 63/735 (8%)
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+IK+ K + + L T R L+ Q+ ++ N KD+EI+ L L+ K+ NE
Sbjct: 766 NIKKNKGVKDWPWWKLF--TTVRPLIEVQLSEEQIRN--KDEEIQQLRSKLEKAEKERNE 821
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L+ +D L + I E +E + + + + T + + EK + E + + +
Sbjct: 822 LRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDA--LK 879
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSELDAGREDCKELCE 261
Q ++ E + + +++N + D + + K E+D ++ ++ E
Sbjct: 880 KQMEVMEMEVMEARL---IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 936
Query: 262 DFTSI----KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK-RNLNSLSEQLINN 316
D + K LE ++ D +E + + K ++ +E++ L+ +Q+ N+
Sbjct: 937 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH 996
Query: 317 ESKK---------------------SKDHIDRYKDSLLA---VLDAEFGTTSLDVFEILM 352
E +K ++ + R KD LLA L + +D+
Sbjct: 997 ELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ 1056
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + +L +I + +K + L + +L+ + K+ +L E+ +L K
Sbjct: 1057 K--VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1114
Query: 413 ERI----HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
R+ + + ++ ++ E++E KL ++++ + + + ++ L
Sbjct: 1115 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1174
Query: 469 FDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L T +++R D+E EK +LR + KA+ + E ++K+
Sbjct: 1175 EGKLATLSDQVNRRDFESEK-RLRKDLKRTKALLADAQLMLDHLKNSAPSKREI-AQLKN 1232
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
EE + V A I+ L +ID + A EE++ L + N E+ +
Sbjct: 1233 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN---EIQNR 1289
Query: 588 INGLKEENNSLKSLNDVITREKE---TQASELERSCQVIKQNGFEL-DKMKADILMXXXX 643
+ +E+ N L + + Q ++L+ + + EL +K++A
Sbjct: 1290 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL 1349
Query: 644 XXXXXXXXXXXXDEAK-SLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
EAK LE L + Q + SRL+ N+ EK E +++ I
Sbjct: 1350 EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENM---EKLTEERDQRIA 1406
Query: 702 RLQKQIQEDDKLFIE-KETK--LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
++ +++ +L + ++TK + EL K R DLES A L L
Sbjct: 1407 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL 1466
Query: 759 VEGRIAELESDIRTE 773
RI +L++ I E
Sbjct: 1467 AFKRIGDLQAAIEDE 1481
Score = 58.4 bits (135), Expect = 1e-07
Identities = 91/407 (22%), Positives = 167/407 (41%), Gaps = 31/407 (7%)
Query: 656 DEAKSLLEQNLALKEQCEEKTR-DCSRLEINIK--THEKTAEIQNRMIMRLQKQIQEDDK 712
DE L L E+ + R + RLE I T E T E + ++
Sbjct: 802 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 861
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSR----EAVNQLTTQKDLVEGRIAELES 768
L EKE K EL +Y+ALK+ + ++ +R +N D + E
Sbjct: 862 LRAEKEMK--ELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYER 919
Query: 769 DIR-TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+R + T GD D E+ + K+ ++
Sbjct: 920 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT- 978
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ K L Q +L+++ + D E E Q Q +L++EK L +
Sbjct: 979 AELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAF 1038
Query: 888 NLKEQIR---------TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+LK+Q+ TQ+ V +A+ D++ +D A+L V +A+V+ +
Sbjct: 1039 SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE- 1097
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELE-ELKQRYK 996
+ ++E Q L+ +++ ME+ + KE E++ +E+E+ + + +LKQ
Sbjct: 1098 --EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1155
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+L+EE E KQ+ + KR E K+A + D+++ + EK++
Sbjct: 1156 QLEEEYED-----KQKVLREKRELEGKLA-TLSDQVNRRDFESEKRL 1196
Score = 56.0 bits (129), Expect = 7e-07
Identities = 136/719 (18%), Positives = 287/719 (39%), Gaps = 47/719 (6%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
+ K + + +E+ +++ ++E TSEL S SQL++ E A LR +KE +
Sbjct: 812 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA-SQLLDAETA-ERLRAEKE-M 868
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ 475
E+ + D +KK+ E+ E+ E + +I+ ++D D A + + ++ + +
Sbjct: 869 KELQTQY--DALKKQMEVMEMEVMEARLIRAAEIN--GEVDDD-DAGGEWRLKYERAVRE 923
Query: 476 YELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL-- 532
+ ++ + E ++KL +E + + L++ + + L EL
Sbjct: 924 VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 983
Query: 533 TKLYKSKVDENNANLNL--------IKILSEEIDALKIAIAK-NEEKMLSLSEK---DNK 580
TKL+ N L + EE K+ K EK + L+E +
Sbjct: 984 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1043
Query: 581 LTELVSTINGLKEENNSLKS-LNDVITREKETQASELERSCQV------IKQNGFELDKM 633
L E I G ++ SL++ L D+ ++E + +AS + Q+ +K ELD+
Sbjct: 1044 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1103
Query: 634 KADILMXXXXXXXXXXXXX----XXXDEAKSLLEQNLALKEQCEEKTRDCS-RLEINIKT 688
I M E +S E+ ++ C++K + +LE +
Sbjct: 1104 AGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1163
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
+K + + +L + ++ E E +L + + +AL D + L++S +
Sbjct: 1164 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS 1223
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
++ K+ +E + ++ + V R+
Sbjct: 1224 KREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREK 1283
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E + + ++ + + + + Q ++DL+ + +E + E + E LQ
Sbjct: 1284 NEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ-INDLQAQLEEANKEKQELQEKLQAL 1342
Query: 869 DEQCARLKK---EKLSLEQQVSNLKEQIRTQQPVER-QAK-FADVAVNTDEDWANLHSVV 923
Q L++ +K + +Q + ++E + T+ ER Q K +A E+ L
Sbjct: 1343 QSQVEFLEQSMVDKSLVSRQEAKIRE-LETRLEFERTQVKRLESLASRLKENMEKLTEER 1401
Query: 924 VDRMSYD-AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R++ + E E+NKRL + +LR K+++ K +A K + + + E+ +
Sbjct: 1402 DQRIAAENREKEQNKRLQR---QLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQ 1458
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+A+L+ +R +L E E + E+ ++ + E+ D++ K L K
Sbjct: 1459 SLQADLKLAFKRIGDLQAAIEDEME-SDENEDLINSEGDSDVDSELEDRVDGVKSWLSK 1516
Score = 51.2 bits (117), Expect = 2e-05
Identities = 74/292 (25%), Positives = 130/292 (44%), Gaps = 38/292 (13%)
Query: 827 DSEVSQLKERLLSCQQELDDLK-----------ERYKELDDECETCAEYLQERDEQCA-- 873
D E+ QL+ +L ++E ++L+ E EL DE T Q D + A
Sbjct: 802 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 861
Query: 874 -RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VN---TDEDWANLHSVVVDRMS 928
R +KE L+ Q LK+Q+ + +A+ A +N D+D + +R
Sbjct: 862 LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAV 921
Query: 929 YDAEVEKNKRLMKTIE-----ELRYKKQ------DLKNTVTKMQKAMEKYTKKDKEFEAK 977
+ + K KRL + E E + K+Q DL+ + Q+A+++ KK + A
Sbjct: 922 REVDFTK-KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA- 979
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR--LKEAKIALEIVDKLSNQ 1035
EL+D K LE + R EL+++ L Q E+ +R L+ K+ E D L +
Sbjct: 980 --ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE-KDMLLAE 1036
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+L++Q+E + ++ T V + A +Q+ + K+ L K+ +L
Sbjct: 1037 AFSLKQQLEE-KDMDIAGFTQKVVSLEAELQDIS-SQESKDEASLAKVKKQL 1086
Score = 49.2 bits (112), Expect = 8e-05
Identities = 104/526 (19%), Positives = 208/526 (39%), Gaps = 38/526 (7%)
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
L++ R K+ + +L + ++ EL ++ +D L E+ S
Sbjct: 793 LSEEQIRNKDEEIQQLRSKLEKAEKERNEL-RLNSDRLESRISELTSELTDERNTGESAS 851
Query: 661 -LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
LL+ A + + E++ ++ L+ +K E+ +M + + ++ +
Sbjct: 852 QLLDAETAERLRAEKEMKE---LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDD 908
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVEGRIAELESDIRTEQTATV 778
E KYE R+ D K L+ E ++ Q K +E R+ +L++D +E++
Sbjct: 909 AGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQAD--SEESQRA 966
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
G + R N +L+ +R DSE+SQ E
Sbjct: 967 LQQLKKKCQRLTAELQDTKLHLEGQQVR----NHELEKKQRRF-----DSELSQAHEEAQ 1017
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ- 897
+ + + L+ L E + + L+E+D A ++ +SLE ++ ++ Q +
Sbjct: 1018 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1077
Query: 898 ---PVERQ-----AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRY 948
V++Q AK D DE + + ++ + E+E+ ++ K +E
Sbjct: 1078 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1137
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
+ ++ + + K K ME + ++E+E K+K L + K ELE D+ E
Sbjct: 1138 EVEEARQSCQKKLKQME--VQLEEEYEDKQKVLRE-KRELEGKLATLS--DQVNRRDFES 1192
Query: 1009 LKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESLSN-TPVSNSTMYVATGSAIVQ 1066
K+ + KR K ++ +D L N + +++I L N S T A +
Sbjct: 1193 EKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVKARKAM 1251
Query: 1067 NQQITDVMKENQKLKKMNAKL---ITICKKRGKTGANRENEDPSDV 1109
+I D+ + + K L ++ ++ NR ED D+
Sbjct: 1252 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM 1297
Score = 48.4 bits (110), Expect = 1e-04
Identities = 98/493 (19%), Positives = 218/493 (44%), Gaps = 59/493 (11%)
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEIN-----IKTHEKTAEIQNRMIMRL------- 703
+E++ L+Q LK++C+ T + +++ ++ HE + Q R L
Sbjct: 961 EESQRALQQ---LKKKCQRLTAELQDTKLHLEGQQVRNHELEKK-QRRFDSELSQAHEEA 1016
Query: 704 QKQIQEDDKLFIEKETKLNELTN-KYEALKRDYDAA--VKDLESSREAVNQLTTQKDLVE 760
Q++ + +KL EK+ L E + K + ++D D A + + S + +++Q+ E
Sbjct: 1017 QREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE 1076
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLDDSPK 819
+A+++ +R + E + + + K +S
Sbjct: 1077 ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD 1136
Query: 820 RSISVISDSEVSQLKERLLSCQQELDD----LKERYKELDDECETCAEYLQERD-EQCAR 874
+ S +LK+ + ++E +D L+E+ +EL+ + T ++ + RD E R
Sbjct: 1137 EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK-RELEGKLATLSDQVNRRDFESEKR 1195
Query: 875 LKKEKLSLEQQVSNLK---EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+K+ + +++ + + ++ P +R+ A + +E + V R + +
Sbjct: 1196 LRKDLKRTKALLADAQLMLDHLKNSAPSKRE--IAQLKNQLEESEFTCAAAVKARKAMEV 1253
Query: 932 EVE----------KNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK- 979
E+E K K L + + L+ +K +++N + + Q+ M + KK K A+
Sbjct: 1254 EIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASR 1313
Query: 980 ---ELEDCKAELEELKQRYKELDEECETC---AEYLKQR--EEQCKRLKEAKIALEIVDK 1031
++ D +A+LEE + +EL E+ + E+L+Q ++ +EAKI E+ +
Sbjct: 1314 DLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR-ELETR 1372
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITIC 1091
L ++ + K++ESL++ N ++Q+I +E ++ K++ +L
Sbjct: 1373 LEFERTQV-KRLESLASRLKENMEKLTEE-----RDQRIAAENREKEQNKRLQRQLRDTK 1426
Query: 1092 KKRGKTGANRENE 1104
++ G+ A +E E
Sbjct: 1427 EEMGEL-ARKEAE 1438
Score = 44.8 bits (101), Expect = 0.002
Identities = 58/280 (20%), Positives = 127/280 (45%), Gaps = 32/280 (11%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLL--------MSQI 112
QS ++ ++ ++LE+ + + +K LEGK L + RD + +
Sbjct: 1144 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT 1203
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN---VTESDNLNKEVD 169
K+L + +KN S + ++ N+L+E T + + E ++L+ ++D
Sbjct: 1204 KALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID 1263
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS 229
D+ K L ++ L++ NE +N++ +E++ N L K +++
Sbjct: 1264 DIAKAKTALEEQLSRLQREKNEIQNRLEED--------QEDM---------NELMKKHKA 1306
Query: 230 ISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD--LDEKLGE 287
+ + S +I LQ++L+ ++ +EL E ++++ +E E +M + + +
Sbjct: 1307 -AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK 1365
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDR 327
E ET+ +++KR L SL+ +L N K +++ R
Sbjct: 1366 IRELETRLEFERTQVKR-LESLASRLKENMEKLTEERDQR 1404
Score = 36.3 bits (80), Expect = 0.61
Identities = 67/383 (17%), Positives = 165/383 (43%), Gaps = 26/383 (6%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI-KSLEMENLTKDKEIK 127
++ K ++L+ EL D K + + L + + D +SQ + + E L ++K ++
Sbjct: 969 QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK-LQ 1027
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC----LTQKCI 183
D L ++ + + EE D + V + +++ + +E + ++
Sbjct: 1028 REKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1087
Query: 184 DLEKLVNESENKI----GPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
DLE V + E ++ G + Q KL+ E ++ + + + + + ++ S +
Sbjct: 1088 DLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQ 1147
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K+ ++ +L+ ED +++ + K LE ++ ++ + E+ + K +K
Sbjct: 1148 -KKLKQMEVQLEEEYEDKQKVLRE----KRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1202
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ + + + L N S SK I + K+ L ++EF + M+ I
Sbjct: 1203 TKALLADAQLMLDHLKN--SAPSKREIAQLKNQL---EESEFTCAAAVKARKAMEVEIED 1257
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE--KENACNILRIQKE--R 414
+ +D+I + T ++ L+ E + +L + E K++ + + ++ +
Sbjct: 1258 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1317
Query: 415 IHEISSAVTIDIVKKENELKEIL 437
I+++ + + + K++ EL+E L
Sbjct: 1318 INDLQAQLE-EANKEKQELQEKL 1339
Score = 33.1 bits (72), Expect = 5.7
Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 933 VEKNKRLMKTIEELRYKKQ-DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
V+KN + K +++ + K + ++Q + E+ KD+E + R +LE + E EL
Sbjct: 763 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNEL 822
Query: 992 KQRYKELDEE-CETCAEYLKQRE--EQCKRLKEAKIALEI-----VDKLSNQKVALEKQI 1043
+ L+ E +E +R E +L +A+ A + + +L Q AL+KQ+
Sbjct: 823 RLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM 882
Query: 1044 E 1044
E
Sbjct: 883 E 883
>AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein.
Length = 1302
Score = 60.9 bits (141), Expect = 2e-08
Identities = 146/742 (19%), Positives = 304/742 (40%), Gaps = 55/742 (7%)
Query: 25 NQLDGAKSKNDNIIETQSN-PIKLQD-SGTITISCKMCQSLKESSNEINLKLEKLSGELF 82
NQ + S+ +++E +S I++ + + + K Q++KE + LE+L +
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+ E+ S L+ + + E + R L ++ ++ME EI++L D L +++
Sbjct: 660 EKVEENSTLQQRLEES--EGELRKNL-EELFQVKMEREQHQTEIRDLQDQLSEMHDELDS 716
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCI-DLEKLVNESENKIGPKNI 201
+ D ++E + ++ +++ K+ E L +K +L L + ++ +
Sbjct: 717 AKRSEDREKGALIEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQ 776
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELD-AGRE-DCKEL 259
KLKE YD L L S+ ++ + + SE D AG E K L
Sbjct: 777 -EMDKLKEQ--------YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E+ ++ E E + L ++ + E KA + + + + + L E L++ K
Sbjct: 828 QEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR-K 885
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
+ K+ + + +L L+ G S E + K + + ++ E+ +++ ++
Sbjct: 886 EEKEAVSARR-ALENELEGAQGNLSQTTQE--QKQLSEKLKEESEQ-KEQLRRLKNEMEN 941
Query: 380 CTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKE-ILT 438
L EKL + ++E + L +Q + + E ++ + + +LKE L
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ-LDEYKEKNRRELAEMQRQLKEKTLE 999
Query: 439 KECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILFDALITQYELSRTDYEIEKEKLRLETG 495
E +L+ +K+ D R ++++L +++ L + + L +YE+E K L+
Sbjct: 1000 AEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA-KSHLKDD 1058
Query: 496 TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSE 555
++ V LEE N L E +++ + ++++ L + +
Sbjct: 1059 RSRLVKQMEAKVSQLEME----LEEERNNSDLLSERISRS-REQMEQLRNGLLQERAARQ 1113
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+++ KI++ + + + S ++ L + KE L + E E +
Sbjct: 1114 DLECGKISLERQNKDLKS------RIIHLEGSYRSSKE---GLVVQMEARIAELEDRLES 1164
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
ER ++ + L++ +++M D+ L + A+K Q EE
Sbjct: 1165 EERDRANLQLSNRRLERKVKELVMQVDDEHLSLT------DQKDQLSLRLKAMKRQVEEA 1218
Query: 676 TRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+ RLE + K ++ E Q M LQ Q+ ++K+ +L +L +K D
Sbjct: 1219 EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS-----MKKDLRLKKLPSKVLDDMDDD 1273
Query: 736 DAAVKDLESSREAVNQLTTQKD 757
D D S EA T KD
Sbjct: 1274 DDLSTDGGSLYEAPVSYTFSKD 1295
Score = 57.2 bits (132), Expect = 3e-07
Identities = 134/669 (20%), Positives = 262/669 (39%), Gaps = 63/669 (9%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLK 172
K LE E + I+ SL +SKK E++ TL T D+ K++
Sbjct: 469 KVLETEGSQESTVIR--APSLGAQSKKEEEVKTATATLMLQNRAAATSPDSGAKKISVKT 526
Query: 173 KNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISD 232
+ TQ DL K G + + Q E + + Y S N +
Sbjct: 527 FPSASNTQATPDLLK---------GQQELTQQTN--EETAKQILYNYLKEGSTDNDDATK 575
Query: 233 SNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE 292
+ + KI TL+S + + C + +K+ LE + +T+++ E L + E
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLE-QKSKLTIEVAE-LQRQLQLE 633
Query: 293 TKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILM 352
K + + E + + + E+L + ++K +++ + L + E ++F++ M
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR--LEESEGELRKNLEELFQVKM 691
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ ++Q ++ ++ ++ +++ +L+ S +S + + +L +L++ + L I K
Sbjct: 692 ER--EQHQTEIRDLQDQLSEMHDELD---SAKRSEDREKGALIEELLQAKQDLQDLLIAK 746
Query: 413 ERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDAL 472
E ++ ++ + LKE ++ ++ KLK +L + ++ T + L
Sbjct: 747 EGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL 806
Query: 473 ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL 532
++ S D + GT V EE V L ++
Sbjct: 807 ASRSNTSEQD----------QAGTEMRVKLLQEENEKLQGRS----EELERRVAQLQRQI 852
Query: 533 TKLYKSKVDENNANLNLIKILSEEIDALKIAI--AKNEEKMLSLSEKDNKLTELVSTING 590
L K DE A L K EI L+ A+ A+ EEK ++S + EL
Sbjct: 853 EDL---KGDEAKAKETLKKY-EGEIRQLEEALVHARKEEKE-AVSARRALENELEGAQGN 907
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
L + K L++ + E E Q +L R ++ + L K +
Sbjct: 908 LSQTTQEQKQLSEKLKEESE-QKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
S LE L E E+ R+ + ++ +K EKT E + + ++ Q D
Sbjct: 967 ---------STLELQNQLDEYKEKNRRELAEMQRQLK--EKTLEAEKSRLTAMKMQ---D 1012
Query: 711 DKLFIEKETKLNELTNKYEALKRDY-DAAVKDLESSREAVNQLTTQKDLV----EGRIAE 765
+E+E + + KR + +KDLE EA + L + + E ++++
Sbjct: 1013 GMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEAKVSQ 1072
Query: 766 LESDIRTEQ 774
LE ++ E+
Sbjct: 1073 LEMELEEER 1081
Score = 56.0 bits (129), Expect = 7e-07
Identities = 98/448 (21%), Positives = 193/448 (43%), Gaps = 58/448 (12%)
Query: 665 NLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNEL 724
NL ++ K+R + N + T+E+++ + + + I+ + ++++ +L E+
Sbjct: 579 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQL-EV 634
Query: 725 TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXX 784
N+ + +K + + +LE R N+ + ++ R+ E E ++R
Sbjct: 635 KNQ-QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 785 XXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL 844
DE DS KRS D E L E LL +Q+L
Sbjct: 694 EQHQTEIRDLQDQLSEMHDEL----------DSAKRS----EDREKGALIEELLQAKQDL 739
Query: 845 DDLKERYKELDDECETCAEYLQERDEQCARLK---KEKLSL-EQQVSNLKEQIRTQ---- 896
DL + +D L++R+ + LK KE++S +Q++ LKEQ +
Sbjct: 740 QDLLIAKEGRED-------LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 897 -QPVERQAKFADVAV---NTDE-DWANLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKK 950
+ VE K +V NT E D A V + +++ +++ L + + +L+ +
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFE-----AKRKELEDCKA------ELEELKQRYKELD 999
+DLK K ++ ++KY + ++ E A+++E E A ELE + +
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTT 912
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+E + +E LK+ EQ ++L+ K +++ N++ L K IE L +++
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLK------NEMENERWHLGKTIEKLQK-EMADIVEASR 965
Query: 1060 TGSAIVQNQQITDVMKENQKLKKMNAKL 1087
T + +QNQ K ++L +M +L
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQL 993
Score = 55.6 bits (128), Expect = 9e-07
Identities = 115/559 (20%), Positives = 234/559 (41%), Gaps = 53/559 (9%)
Query: 525 VKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKMLS---L 574
++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E + S
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQVIKQNG 627
SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ + +K+
Sbjct: 813 SEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYE 870
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRDCSRLEI 684
E+ +++ ++ +E A+ L Q ++Q EK ++ S +
Sbjct: 871 GEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDAAVKDL- 742
++ + E + + + +++Q++ +E T EL N+ + K + ++
Sbjct: 931 QLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ 990
Query: 743 ----ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXX 798
E + EA T + +G + +E ++R Q A
Sbjct: 991 RQLKEKTLEAEKSRLTAMKMQDG-MRLMEEELRDYQRAQ----------DEALTKRQLLE 1039
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
T D +L L D R + + +++VSQL+ L + D L ER ++
Sbjct: 1040 QTLKDLEYELEAKSHLKDDRSRLVKQM-EAKVSQLEMELEEERNNSDLLSERISRSREQM 1098
Query: 859 ETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
E L + L+ K+SLE+Q +LK +I + R +K + V + A
Sbjct: 1099 EQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIHLEGSYRSSK-EGLVVQMEARIAE 1157
Query: 919 LHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK 977
L + A ++ N+RL + ++EL + D ++T + + K A
Sbjct: 1158 LEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK------AM 1211
Query: 978 RKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIALEIVDKLS 1033
++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+ +++D +
Sbjct: 1212 KRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMD 1271
Query: 1034 NQKVALEKQIESLSNTPVS 1052
+ L SL PVS
Sbjct: 1272 DDD-DLSTDGGSLYEAPVS 1289
Score = 51.6 bits (118), Expect = 2e-05
Identities = 98/548 (17%), Positives = 217/548 (39%), Gaps = 40/548 (7%)
Query: 550 IKILSEEIDALKIAIAKNEEKM-LSLSEKDNKLTE---LVSTINGLKEENNSLKSLNDVI 605
+K L E+ L I +A+ + ++ L + + N E + + + L+ ++N N +
Sbjct: 609 VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTL 668
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADI--LMXXXXXXXXXXXXXXXXDEAK--SL 661
+ E EL ++ + + Q E ++ + +I L ++ + +L
Sbjct: 669 QQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL 728
Query: 662 LEQNLALKEQCEEKT-RDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
+E+ L K+ ++ R ++ K + ++ + + QE DKL + + +
Sbjct: 729 IEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAE 788
Query: 721 LN-------ELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
L E T E L + + +D + V L + + ++GR ELE +
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 774 QTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQL 833
Q + + K S +R++ ++E+
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRAL----ENELEGA 904
Query: 834 KERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI 893
+ L QE L E+ KE ++ E E + + L K L+++++++ E
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Query: 894 RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQD 952
RT +E Q + + + A + + ++ E EK++ MK + +R +++
Sbjct: 965 RTST-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAMKMQDGMRLMEEE 1020
Query: 953 LKNTVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAELEELKQRYKELDEECE-- 1003
L++ +A+ K T KD E+E AK +D +++++ + +L+ E E
Sbjct: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEAKVSQLEMELEEE 1080
Query: 1004 -----TCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIESLSNTPVSNSTMY 1057
+E + + EQ ++L+ + L K++LE+Q + L + + Y
Sbjct: 1081 RNNSDLLSERISRSREQMEQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIHLEGSY 1140
Query: 1058 VATGSAIV 1065
++ +V
Sbjct: 1141 RSSKEGLV 1148
>AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 14
isoform protein.
Length = 972
Score = 60.9 bits (141), Expect = 2e-08
Identities = 115/536 (21%), Positives = 224/536 (41%), Gaps = 43/536 (8%)
Query: 126 IKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDL 185
I +L S +I + QE L + + E L E+ + CL I
Sbjct: 409 IHSLGKSTTDNDVRIQQPQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-- 466
Query: 186 EKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTL 245
+E+ + + K Q + +E + + L + L ++ D+ + ++++
Sbjct: 467 ----SENSSDLSQKLKETQSQYEEAMKEVLSVQKQMKLGLVSPESMDNYS--HFHELRVT 520
Query: 246 QSELDAGREDCKELCEDFTSIKNHL-ELHEPNMTMDLDEKLGEN-NEFETKAVKVMSEIK 303
+ E++ ++D + E+ K + EL E + + + E+E S I+
Sbjct: 521 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 580
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL--MDNIINKYQI 361
N+N + + + ++++ I KD+L + + E + D+ E + M + +NK
Sbjct: 581 -NMNK-EKAFLFEKYPEAQEGIMELKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 638
Query: 362 DLDEI-------LEKYTKVQGDLNECTSEL--KSVNEKLASL-NSQLIEKENACNILRIQ 411
+L ++ LE Y K + L + T+E K+ +EKL L N + E+A + ++ Q
Sbjct: 639 ELSQLYKEAQAELEDYRK-RKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 697
Query: 412 KERI-HEISSAVTIDIVKKENELK-----EILT------KECL-KLSKLKIDIPRDLDQD 458
++ +E++ + +KEN + +++T KE K+S LK + +
Sbjct: 698 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 757
Query: 459 LPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
L K++ + A +T + R+ YE + L E + +
Sbjct: 758 LKLEKQL-LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 816
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
++VK E + L KSK E N L + EE+ +K A++ K+ +KD
Sbjct: 817 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMK-RYAESSSKL--EEDKD 873
Query: 579 NKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
K+ E+ + LKE NSL L+ T + Q+ +LE Q +KQ +L + K
Sbjct: 874 KKINEMSKEVTKLKEALNSLSQLS-YSTSSSKRQSQQLEALQQQVKQLQNQLAECK 928
Score = 59.3 bits (137), Expect = 8e-08
Identities = 107/506 (21%), Positives = 218/506 (43%), Gaps = 52/506 (10%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLN--LIKILSEEIDALKIAIAKNEEKMLSL---SEKD 578
E++S EL L +++ EN+++L+ L + S+ +A+K ++ ++ L L D
Sbjct: 450 ELQSRRAELVCLNNTEISENSSDLSQKLKETQSQYEEAMKEVLSVQKQMKLGLVSPESMD 509
Query: 579 N-----KLTELVSTINGLKEE-NNSLKSL--NDVITREKETQASELERSCQVIKQNGFEL 630
N +L IN LK++ N+L+ N RE E + E E+ VIK E
Sbjct: 510 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT-VIKPPVEEY 568
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKS-LLEQNLALKEQCEEKTRDCSRLEINIKTH 689
++MK+ EA+ ++E LK Q ++ D +
Sbjct: 569 EEMKSSYCSVIENMNKEKAFLFEKYPEAQEGIMELKDTLKSQMTQEASDEA--------- 619
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDL-ESSREA 748
E E NRMI L KQ+ E +L+ E + +L + Y K D + + ++ E
Sbjct: 620 EDMKEAMNRMIDELNKQVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHKAEHEK 675
Query: 749 VNQLT-TQKDLVEGRIAELESD---IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE 804
+ QLT + E ++E++S + E T T
Sbjct: 676 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTA 735
Query: 805 NRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL---KERYKE----LDDE 857
+++ E K+ + + S + EV +L+++LL + + D + Y++ L+ E
Sbjct: 736 AKEMEE--KISNLKEHLAS--KEVEVLKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE 791
Query: 858 CETCAEYLQERDEQCARLKKEKLSLEQQVSNL---KEQIRTQQPVERQA--KFADVAVNT 912
A L+E ++ ++ E + + +VS + KE I+T + Q +
Sbjct: 792 VSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA 851
Query: 913 DEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDK 972
E+ A + S E +K+K++ + +E+ K+ L N+++++ + ++ +
Sbjct: 852 QEELAEMKRYA--ESSSKLEEDKDKKINEMSKEVTKLKEAL-NSLSQLSYSTSSSKRQSQ 908
Query: 973 EFEAKRKELEDCKAELEELKQRYKEL 998
+ EA +++++ + +L E K++++E+
Sbjct: 909 QLEALQQQVKQLQNQLAECKKQHQEV 934
Score = 55.6 bits (128), Expect = 9e-07
Identities = 54/260 (20%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKK----EKLSLEQQVSNLKEQIRTQQ 897
Q + L+ KE++++ E+L ++ + +L+K EK ++ + + Q
Sbjct: 727 QVITTLRTAAKEMEEKISNLKEHLASKEVEVLKLEKQLLEEKAAMTDAMVPRSSYEKLQS 786
Query: 898 PVERQAK-FADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+E + A + ++ +HS VV S ++V++ K ++T+ L+ K+Q++
Sbjct: 787 SLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTL--LKSKEQEVNEL 844
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
+ K Q+A E+ + + E+ K ED ++ E+ + +L E + ++
Sbjct: 845 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSK 904
Query: 1017 KRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
++ ++ + + V +L NQ +KQ + + +S M++ VQ Q DV
Sbjct: 905 RQSQQLEALQQQVKQLQNQLAECKKQHQEV----ISVYRMHLLYA---VQGQMDEDV--- 954
Query: 1077 NQKLKKMNAKLITICKKRGK 1096
QK+ K +++T+CK + +
Sbjct: 955 -QKVLK---QILTMCKNQSQ 970
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/196 (23%), Positives = 92/196 (46%), Gaps = 12/196 (6%)
Query: 75 EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLK 134
EKL L + + S L K + + E + + QI+S E+ + ++KE N+ LK
Sbjct: 782 EKLQSSL---ESEVSVLASKLKESVKEKEKVHSEVVQIRS-EVSQVKREKE--NIQTLLK 835
Query: 135 TKSKKINELQEENDTLSNLIMENVTESDNLNK-EVDDLKKNNECLTQKCIDLEKLVNE-S 192
+K +++NEL ++ + E +++ +K E D KK NE ++++ L++ +N S
Sbjct: 836 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINE-MSKEVTKLKEALNSLS 894
Query: 193 ENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAG 252
+ + Q + E L Q + N L++ + + + R + + +Q ++D
Sbjct: 895 QLSYSTSSSKRQSQQLEALQQQVK-QLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDED 953
Query: 253 REDCKELCEDFTSIKN 268
+ K L + T KN
Sbjct: 954 VQ--KVLKQILTMCKN 967
>AY165122-1|AAO39147.1| 1995|Homo sapiens myosin heavy chain protein.
Length = 1995
Score = 60.9 bits (141), Expect = 2e-08
Identities = 104/584 (17%), Positives = 220/584 (37%), Gaps = 32/584 (5%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKIL----------SEEIDALKIAIAKNE 568
EE ++ EEL DE A L+K L E++++ ++A K E
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1155
Query: 569 EKMLSLSEKDNKLT-ELVSTINGLKEENNSLKSLNDVITREKETQASEL---ERSCQVIK 624
++ L E+ L EL T++ + +T K+T E E + Q ++
Sbjct: 1156 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1215
Query: 625 Q-NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
Q +G L ++ + E L + +L+ +E + RLE
Sbjct: 1216 QRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE 1275
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLE 743
+ ++ + A R +++Q LNE +K L ++ + L
Sbjct: 1276 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1335
Query: 744 SSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
++E + + T K + R+ +E++ + +
Sbjct: 1336 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRR 1395
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
+ + + +R + E L +RL + +D L+ + L E +
Sbjct: 1396 RQEEEAGALEAGEEARRRAA----REAEALTQRLAEKTETVDRLERGRRRLQQELDDATM 1451
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
L+++ + + L+K++ +Q ++ +E+ + VE + + + +L +
Sbjct: 1452 DLEQQRQLVSTLEKKQRKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRAL 1509
Query: 924 VDRMSYDAEVEKNKRLMKT-IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
+ E+E+ R ++ +E L K D+ +V ++++A + + A+ ELE
Sbjct: 1510 EEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELE 1569
Query: 983 DCKAELEELKQRYKELDEECETCAEY-LKQREEQ--------CKRLKEAKIALEIVDKLS 1033
D E+ K R + + +T E L+ R+E K+L++A++ + K
Sbjct: 1570 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1629
Query: 1034 NQKVALEKQIE-SLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
VA K++E L ++ A+ Q +++ MKE
Sbjct: 1630 TLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1673
Score = 54.8 bits (126), Expect = 2e-06
Identities = 146/828 (17%), Positives = 314/828 (37%), Gaps = 46/828 (5%)
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK- 303
L EL+A R + ++ D T+ + L +L + L E AV+ + +
Sbjct: 1161 LGEELEALRGELEDTL-DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 304 RNLNSLSEQLINNESKKSKDHIDRYKDSLLA-VLDAEFGTTSLDVFEILMDNIINKYQID 362
+ L L+EQL ++++ K ++ + +L A V + +SL + + ++
Sbjct: 1220 QALGELAEQL--EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1277
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIH-EISSA 421
L E+ + + E +L+ +L +++ L E E+ +R+ KE E
Sbjct: 1278 LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES--KTIRLSKELSSTEAQLH 1335
Query: 422 VTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRT 481
+++++E K L + + L+++ A ++ + Q +LS
Sbjct: 1336 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR--ELQTAQAQLSEW 1393
Query: 482 DYEIEKEKLRLETG--TAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSK 539
E+E LE G + +T++ + L +EL
Sbjct: 1394 RRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1453
Query: 540 VDENNANLNLIK-------ILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLK 592
+ L K +L+EE A+ A+ + E E++ + L + +
Sbjct: 1454 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1513
Query: 593 EENNSLKSLNDVITREKETQAS----------ELERSCQVIKQNGFELDKMKADILMXXX 642
E L+ N + E E S ELER+C+V +Q +L ++
Sbjct: 1514 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1573
Query: 643 XXXXXXXXXXXXXDEAKSLLEQNLALKEQC-EEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
K+ E++L +++ EE+ R ++ + + Q + +
Sbjct: 1574 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1633
Query: 702 RLQKQIQEDDKLFIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLV 759
+K+++ + L K + K EA+K R A +K+L RE V + T ++ +
Sbjct: 1634 AARKKLEGE--LEELKAQMASAGQGKEEAVKQLRKMQAQMKELW--RE-VEETRTSREEI 1688
Query: 760 EGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE--NRDLGENPKLDDS 817
+ E E ++ + + DE N +L + L++
Sbjct: 1689 FSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEE- 1747
Query: 818 PKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKK 877
KR + + + QL+E L Q + L +RY++L + E+ L A+ +
Sbjct: 1748 -KRQL----EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1802
Query: 878 EKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK 937
+ LE+Q+ L+ ++ + R +A + + + + +
Sbjct: 1803 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862
Query: 938 RLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKE 997
R K ++E+ + ++ + +++ +EK + K+ + + +E E+ + + ++R +
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922
Query: 998 LDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
E+ AE + RE R + + L + Q LE+ + S
Sbjct: 1923 ELEDVTESAESM-NREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVAS 1969
Score = 46.4 bits (105), Expect = 6e-04
Identities = 76/349 (21%), Positives = 139/349 (39%), Gaps = 25/349 (7%)
Query: 683 EINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE--TKLNELTNKYEALKRDYDAAVK 740
E+ ++ + E+Q R+ +++ + ++L E E + E + A K++ + V
Sbjct: 883 ELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVS 942
Query: 741 DLES----SREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXX 796
+LE+ E Q+ T+K ++ I ELE+ + E+ A
Sbjct: 943 ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1002
Query: 797 XXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD 856
D+N KL S V S QL+ R S R
Sbjct: 1003 DLLLLEDQNS------KLSKSGSCWKIVWPSSHPRQLRRRRRSRASISYGSNMR-----P 1051
Query: 857 ECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDW 916
+ +T + L++ ++ L+K K L+ + S L+EQ+ QQ + + A + +E
Sbjct: 1052 QSQTWRDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR-AQLGRKEEELQ 1110
Query: 917 ANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
A L + A + K L + L ++DL++ KA ++ +E EA
Sbjct: 1111 AALARAEDEG---GARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1167
Query: 977 KRKELED----CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKE 1021
R ELED A+ E +R +E+ E +T E + E + L++
Sbjct: 1168 LRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQ 1216
Score = 35.9 bits (79), Expect = 0.80
Identities = 50/243 (20%), Positives = 102/243 (41%), Gaps = 34/243 (13%)
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQER---DEQCAR-LKKEKLSLEQQVS 887
QL+ C E ++ + R E E L+ R +E+C+R ++ EK L+Q +
Sbjct: 912 QLRAEAELCA-EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ 970
Query: 888 NLKEQIRTQQPVERQAKFADVAVNT-----DEDWANLHS------------VVVDRMSYD 930
L+ + ++ ++ + V +ED L +V S+
Sbjct: 971 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKSGSCWKIVWPSSHP 1030
Query: 931 AEVEKNKRLMKTI---EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
++ + +R +I +R + Q ++ + K +K ++ K + + + EL++ E
Sbjct: 1031 RQLRRRRRSRASISYGSNMRPQSQTWRDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1090
Query: 988 ----LEELKQRYKELDEECETCAEYLKQ----REEQCKRLKEAKIAL-EIVDKLSNQKVA 1038
EEL+ + +EE + + R + K L+EA+ AL E + L +++VA
Sbjct: 1091 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA 1150
Query: 1039 LEK 1041
K
Sbjct: 1151 RTK 1153
Score = 35.5 bits (78), Expect = 1.1
Identities = 104/523 (19%), Positives = 205/523 (39%), Gaps = 45/523 (8%)
Query: 556 EIDALKIAIAKNEEKMLSLS-EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
E++ + A+ + E K + LS E + +L L+EE + +L + R E +A+
Sbjct: 1305 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV-RAMEAEAA 1363
Query: 615 ----ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
+LE ++ G EL +A + + + + AL +
Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ 1423
Query: 671 QCEEKTRDCSRLE-----INIKTHEKTAEI--QNRMIMRLQKQIQEDDKLFIEKET---K 720
+ EKT RLE + + + T ++ Q +++ L+K+ ++ D+L E++ +
Sbjct: 1424 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR 1483
Query: 721 LNELTNKYEALKRDYDA----AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
E + EA R+ +A + LE +EA +L Q + + L S + +
Sbjct: 1484 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS-KDDVGK 1542
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+V T ++ E+ KL + ++V + ER
Sbjct: 1543 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL----RLEVTV---QALKTQHER 1595
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT- 895
L + E + ER ++L + E +Q + LE ++ LK Q+ +
Sbjct: 1596 DLQGRDEAGE--ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1653
Query: 896 -QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEE--LRYKKQD 952
Q E + + E W + R ++ ++++ +K +E LR +++
Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1713
Query: 953 LKNTVTKMQKAMEKYTKKDKEFE---AKRKELEDCKAELE-ELKQRYKELDEECETCAEY 1008
+ + Q ++ D+ +K LE+ K +LE L Q +EL+EE ++ +E
Sbjct: 1714 AASDRARRQAQQDRDEMADEVANGNLSKAAILEE-KRQLEGRLGQLEEELEEE-QSNSEL 1771
Query: 1009 LKQREE----QCKRL-KEAKIALEIVDKLSNQKVALEKQIESL 1046
L R Q + L E K + + LE+QI+ L
Sbjct: 1772 LNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1814
>AL590431-11|CAH71269.1| 284|Homo sapiens tropomyosin 3 protein.
Length = 284
Score = 60.9 bits (141), Expect = 2e-08
Identities = 51/253 (20%), Positives = 117/253 (46%), Gaps = 13/253 (5%)
Query: 807 DLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
D E + + S + E++ ++++L + ELD E K+ ++ E +
Sbjct: 20 DRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAA 79
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQ-QPVERQAKFAD-------VAVNT---DED 915
+ + + A L + +E+++ +E++ T Q +E K AD V N DE+
Sbjct: 80 DAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEE 139
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
L + + + AE E +++ + +L + DL+ T + + A K ++ ++E +
Sbjct: 140 KMELQEIQLKEAKHIAE-EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 198
Query: 976 AKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSN 1034
L+ +A+ E+ Q+ + +EE + + LK+ E + + + + LE +D L +
Sbjct: 199 NVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLED 258
Query: 1035 QKVALEKQIESLS 1047
+ A + + +++S
Sbjct: 259 ELYAQKLKYKAIS 271
Score = 58.0 bits (134), Expect = 2e-07
Identities = 56/233 (24%), Positives = 101/233 (43%), Gaps = 9/233 (3%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KLD + +++E Q +ER + EL ++++ K +DE + +E L++ E+
Sbjct: 12 KLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKL 71
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
+K+ E +V++L +I Q VE + A + T D +
Sbjct: 72 ELAEKKAADAEAEVASLNRRI---QLVEEELDRAQERLATALQKLEEAEKAADESERGMK 128
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
V +N R +K E++ ++ LK ++A KY + ++ +LE + E +
Sbjct: 129 VIEN-RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAE 187
Query: 993 QRYKELDEECETCAEYLKQREEQCKRL--KEAKIALEI---VDKLSNQKVALE 1040
+ EL+EE + LK E Q ++ KE K EI DKL + E
Sbjct: 188 SKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAE 240
Score = 35.9 bits (79), Expect = 0.80
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 24/236 (10%)
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEV---- 168
K LE E K++K D L S+ + + QE+ + + E +LN+ +
Sbjct: 37 KQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVE 96
Query: 169 DDLKKNNECLT---QKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
++L + E L QK + EK +ESE G K I + E ++ I +K
Sbjct: 97 EELDRAQERLATALQKLEEAEKAADESER--GMKVIENRALKDEEKMELQEIQLKE--AK 152
Query: 226 LNRSISDSNTSTRYNKICTLQSELDAGRE-------DCKELCEDFTSIKNHLELHEPNMT 278
+D K+ ++ +L+ E C EL E+ ++ N+L+ E
Sbjct: 153 HIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQA- 211
Query: 279 MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
EK + + + +K++++ + + +E + +K K ID +D L A
Sbjct: 212 ----EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKT-IDDLEDELYA 262
Score = 33.1 bits (72), Expect = 5.7
Identities = 30/165 (18%), Positives = 65/165 (39%), Gaps = 1/165 (0%)
Query: 607 REKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL 666
R K+ + EL + +K ELDK + E SL +
Sbjct: 35 RSKQLE-DELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQ 93
Query: 667 ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTN 726
++E+ + + ++ EK A+ R + ++ + +D++ +E +L E +
Sbjct: 94 LVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 153
Query: 727 KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
E R Y+ + L + + + +L E + +ELE +++
Sbjct: 154 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELK 198
Score = 32.3 bits (70), Expect = 9.9
Identities = 47/218 (21%), Positives = 89/218 (40%), Gaps = 21/218 (9%)
Query: 246 QSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRN 305
Q +L+ + + + S+ ++L E + E+L + +A K E +R
Sbjct: 68 QEKLELAEKKAADAEAEVASLNRRIQLVEEELDR-AQERLATALQKLEEAEKAADESERG 126
Query: 306 LNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE 365
+ + + + +E K I + K++ +A+ + ++++ DL+
Sbjct: 127 MKVIENRALKDEEKMELQEI-QLKEAKHIAEEADRKYEEVARKLVIIEG-------DLER 178
Query: 366 ILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTID 425
E+ + +E ELK+V L SL +Q EK + QKE +E + D
Sbjct: 179 TEERAELAESKCSELEEELKNVTNNLKSLEAQ-AEKYS-------QKEDKYEEEIKILTD 230
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHK 463
+K+ E + KL K ID DL+ +L A K
Sbjct: 231 KLKEAETRAEFAERSVAKLEK-TID---DLEDELYAQK 264
>AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein
protein.
Length = 2121
Score = 60.9 bits (141), Expect = 2e-08
Identities = 193/1063 (18%), Positives = 419/1063 (39%), Gaps = 81/1063 (7%)
Query: 58 KMCQSLKESSNEINLKLEKLS---GEL-FDIKEQKSALEGKYQNLILETQ-----TRDLL 108
K CQ LK ++++ K+ +LS G+L F ++E S L+ L T+ T++ L
Sbjct: 303 KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWL 362
Query: 109 MSQIK-SLEMENLTKDK---EIKN--LTDSLKTKSKKINELQEENDTLSNLIMENVTESD 162
Q + E+ +DK E KN L L + +++LQ+ ++ +V + +
Sbjct: 363 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 422
Query: 163 NLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNT 222
L +E L NN L + LE + E K+ + + ++ + SL ++
Sbjct: 423 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER--GHFEEEKQQLSSLITDLQSS 480
Query: 223 LSKLNRSISDSNTSTRYN------KICTLQSELDAGREDCKELCEDFTSIKNHLELHEPN 276
+S L+++ + +++ + ++ +L SEL ++ ++ +K + +
Sbjct: 481 ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ 540
Query: 277 MTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVL 336
+ L ++ + + ++ S +K+ L E E+ + +DH + A
Sbjct: 541 LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR-QDHAQQLAT---AAE 596
Query: 337 DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNEC--TSELKSVNEKLASL 394
+ E D ++ + + L EIL++ +V + + TS ++ EK A L
Sbjct: 597 EREASLRERDAALKQLEALEKEKAAKL-EILQQQLQVANEARDSAQTSVTQAQREK-AEL 654
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
S+ +E+ AC + ++ HE + V ++ +E ++ KE + K
Sbjct: 655 -SRKVEELQAC--VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK------DQ 705
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXX 510
L + L A K+ + + + + D E+++ L+ ET +
Sbjct: 706 LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 765
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
LE ++ H+ T++ + ++ E A + + E++ +K A E
Sbjct: 766 ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL--VKEVAAWRERY 823
Query: 571 MLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFEL 630
S E+ + LKEE K+ ++ +++ E Q+ +Q EL
Sbjct: 824 EDSQQEEAQYGAMFQEQLMTLKEECE--KARQELQEAKEKVAGIESHSELQISRQQN-EL 880
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
++ A++ D+ +L E+ A +++ +RLE ++
Sbjct: 881 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT-------SKEVARLETLVRKAG 933
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNK--YEALKRDYDAAVKDLESSREA 748
+ E +R +++ + + ++E++ + + +A++R+ + +LE R A
Sbjct: 934 EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 993
Query: 749 VNQLTTQKDLVEGR----IAELESDI-RTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
+ + Q+ G+ +A L + R + + F
Sbjct: 994 LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1053
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
L + + ++ + E +Q+KE L +Q + LKE+ + + E + +
Sbjct: 1054 LQEALAHALTEKEGKDQELAKLRGLEAAQIKE-LEELRQTVKQLKEQLAKKEKEHASGSG 1112
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
E + + +L +VS L++Q + QQ QA + ++ +
Sbjct: 1113 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ---EQADSLERSLEAERASRAERDSA 1169
Query: 924 VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELED 983
++ + E EK + L + L +++L TK+Q ++K + E++A ++
Sbjct: 1170 LETLQGQLE-EKAQELGHSQSALASAQRELAAFRTKVQD----HSKAEDEWKA---QVAR 1221
Query: 984 CKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+ E E L+EE + ++E + K LK L + + +QK LE+++
Sbjct: 1222 GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR----LVMAESEKSQK--LEERL 1275
Query: 1044 ESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAK 1086
L SNS SA+ + Q E Q++ N +
Sbjct: 1276 RLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLR 1318
Score = 57.2 bits (132), Expect = 3e-07
Identities = 182/995 (18%), Positives = 376/995 (37%), Gaps = 68/995 (6%)
Query: 100 LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
LE + + L + +SL M K+ ++L +KIN+L EEN LS + E +
Sbjct: 279 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 338
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGY 219
L +++L + + TQ+ ++ + + + + C + K ++Q
Sbjct: 339 HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE--EKNEILQGKLSQL 396
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTM 279
+ LS+L N ++ +L+ +++ L + T ++ +E+ E
Sbjct: 397 EEHLSQL-----QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ 451
Query: 280 DLDEKLGENNEFETKAVKVMS---EIKRNLNSLSE--QLINNESKKSKDHIDRYKDSLLA 334
+ L E FE + ++ S +++ ++++LS+ + + S+ + SL +
Sbjct: 452 QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS 511
Query: 335 VLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLAS 393
L T E+ + + Q L + L++ + L +L S ++
Sbjct: 512 ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ 571
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
++ EK+ A + +++ + + +++ LK++ E K +KL+I + +
Sbjct: 572 QLKEVAEKQEATR--QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI-LQQ 628
Query: 454 DLDQDLPAHKKI-TILFDALITQYELSRTDYEIEK--EKLRLETGTAKAVXXXXXXXXXX 510
L A T + A + ELSR E++ E R E A+A
Sbjct: 629 QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 688
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKS-KVDENNANLNLIKILSEEIDALKIAIAKNEE 569
E E L E+L L +S KV + + + ++ ++ + I++ +
Sbjct: 689 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEK-RRAADALEEQQRCISELKA 747
Query: 570 KMLSLSEKDNK-LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ SL E+ + EL G K L+ L + E E EL +
Sbjct: 748 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES 807
Query: 629 ELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKT 688
E +++ ++ EQ + LKE+CE+ ++ + +
Sbjct: 808 ECEQLVKEV---AAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 864
Query: 689 HEKTAEI----QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD--- 741
E +E+ Q + L + + EKE + +L + L+ A K+
Sbjct: 865 IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 924
Query: 742 LES--SREAVNQLTTQKDLVE--GRIAELESDIRTEQ-------TATVXXXXXXXXXXXX 790
LE+ + Q T ++LV+ R + + + EQ T
Sbjct: 925 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 984
Query: 791 XXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQEL---DDL 847
+ + E + + R ++ E+ + E+ + L
Sbjct: 985 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1044
Query: 848 KERYKELDDECETCAEYLQE---RDEQCARLK-------KEKLSLEQQVSNLKEQIRTQQ 897
E+ E E A L E +D++ A+L+ KE L Q V LKEQ+ ++
Sbjct: 1045 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1104
Query: 898 PVERQAKFA--DVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR----LMKTIEELRYKKQ 951
A + A T+ L ++ + + + +K + L +++E R +
Sbjct: 1105 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1164
Query: 952 DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE-ECETCAEYLK 1010
+ + + +Q +E +K +E + L + EL + + ++ + E E A+ +
Sbjct: 1165 ERDSALETLQGQLE---EKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1221
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIES 1045
R+E +R +LE + N++V LEK+ ES
Sbjct: 1222 GRQE-AERKNSLISSLEEEVSILNRQV-LEKEGES 1254
Score = 50.4 bits (115), Expect = 3e-05
Identities = 181/981 (18%), Positives = 390/981 (39%), Gaps = 95/981 (9%)
Query: 103 QTRDLLMSQIKS-LEMENLTKDKEIKNLTDSLKTKSKK---INELQEENDTLSNLIMENV 158
QT M ++K L E +D+ L ++ K ++K I +Q+ D L+ L+ E
Sbjct: 216 QTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQ 274
Query: 159 TESDNLNKEVDDLKKNNECLT-------QKCIDLEKLVNESE---NKIGPKNICAQCKLK 208
S KE+++L+ NE LT ++C DL+ ++ + N++ +N KL+
Sbjct: 275 AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 334
Query: 209 E--NLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE----- 261
E + +Q L + L++L S + T K L+ EL A +D K L E
Sbjct: 335 EFASHLQQL----QDALNELTEEHSKA-TQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 389
Query: 262 --DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVM------SEIKRNLNSLSEQL 313
+ ++ HL + N + E LG+ + ET + ++++ + L +
Sbjct: 390 QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 449
Query: 314 INNESK--KSKDHIDRYKDSLLAVL-DAEFGTTSLDVFEILMDNIINKYQIDLDEILEKY 370
E+K + H + K L +++ D + ++L + + + Q + +
Sbjct: 450 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK---EELEQASQAHGARLTAQV 506
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI-----HEISSAVTID 425
+ +L + ++ +++LA L Q EK+ Q+E+ H++ ++
Sbjct: 507 ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ-LSSS 565
Query: 426 IVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEI 485
+ +KE +LKE+ K+ + D + L + DA + Q E +
Sbjct: 566 LKQKEQQLKEVAEKQ----EATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 621
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ E L+ + A L E+++ E + + + A
Sbjct: 622 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC-VETARQEQHEAQAQVA 680
Query: 546 NLNLIKILSEEIDAL-KIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDV 604
L L ++ SE+ A K +A+ +++ L E+ L E + G EE + D
Sbjct: 681 ELEL-QLRSEQQKATEKERVAQEKDQ---LQEQLQALKESLKVTKGSLEEEK--RRAADA 734
Query: 605 ITREKETQASELERSCQVI----KQNGFELDKMKA-----DILMXXXXXXXXXXXXXXXX 655
+ E++ SEL+ + + K+ EL++ +A + +
Sbjct: 735 L-EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR 793
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCS----RLEINIKTHEKTAEIQNRMIMRLQKQIQEDD 711
+ A+++ Q+ A + +CE+ ++ + R E + + + + +M L+++ ++
Sbjct: 794 ELAEAMAAQHTA-ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 852
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+ E + K+ + + E + +L ++ Q +K++ R +L D+
Sbjct: 853 QELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV---RAQKLADDLS 909
Query: 772 TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP-KLDDSPKRSISVISDSEV 830
T Q T +R+L + P + D + +
Sbjct: 910 TLQEKMAATSKEVARLETLVRKAGEQQET---ASRELVKEPARAGDRQPEWLEEQQGRQF 966
Query: 831 SQLKERLLSCQQELDDLKERYKELDDE-CETCAEYLQERDEQ---CARLKKEKLSLEQQV 886
+ L + ++E + + + L E+ + +ER +Q ARL +E+ + +
Sbjct: 967 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1026
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL----MKT 942
+ L++ R + + Q + V L + ++ D E+ K + L +K
Sbjct: 1027 A-LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE 1085
Query: 943 IEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK----ELEDCKAELEELKQRYKEL 998
+EELR + LK + K +K + E + + +LE +AE+ +L+Q+ ++
Sbjct: 1086 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1145
Query: 999 DEECETCAEYLK-QREEQCKR 1018
E+ ++ L+ +R + +R
Sbjct: 1146 QEQADSLERSLEAERASRAER 1166
Score = 49.2 bits (112), Expect = 8e-05
Identities = 127/687 (18%), Positives = 261/687 (37%), Gaps = 46/687 (6%)
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKI--DIPRDLDQDL 459
+NA N R++ + E + + K+ EL ++ E ++ +L+ + L + L
Sbjct: 1041 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1100
Query: 460 PAHKKITILFDALITQYELSRTDYEIEK-EKLRLETGTAKAVXXXXXXXXXXXXXXFDTL 518
+K ++ RT+ K E LR E + +
Sbjct: 1101 AKKEKEHASGSGAQSE-AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1159
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAI---AKNEEKMLSLS 575
+ E S E L + K E + + + E+ A + + +K E++ +
Sbjct: 1160 RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1219
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
+ + E +++ EE S+ LN + EKE ++ EL+R + +L++ +
Sbjct: 1220 ARGRQEAERKNSLISSLEEEVSI--LNRQVL-EKEGESKELKRLVMAESEKSQKLEE-RL 1275
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH-EKTAE 694
+L + + +L E+ +L+E+ E++ L + + E+ E
Sbjct: 1276 RLLQAETASNSARAA-----ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1330
Query: 695 IQNRMIMRLQKQIQEDDKLF-IEKE-TKLNELTNKY-------EALKRDYDAAVK----D 741
+ + +K Q++ L ++ E T L ++ + L+ + AA K +
Sbjct: 1331 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1390
Query: 742 LESSREAVNQLTTQKDLVE---GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXX 798
LE S++A L + + G + L + ++
Sbjct: 1391 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1450
Query: 799 XTFGDENRDLGENPKLDDS-PKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDE 857
+ENR LGE L + + + V +L + L +++ + E
Sbjct: 1451 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1510
Query: 858 CETC-AEYLQERD---EQCARLKKEKLSLEQQVSNLK--EQIRTQQPVERQAKFADVAVN 911
E A+Y + E+ R ++E+ L QV L+ ++ +T+Q E K AD
Sbjct: 1511 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQA 1570
Query: 912 TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIE-ELRYKKQDLKNTVTKMQKAMEKYTKK 970
+ L +V E ++ + + ++ +L K+Q ++ +M+KA Y K
Sbjct: 1571 SKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK 1630
Query: 971 DKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEI-V 1029
++ +EL++ LE+L++ KEL E E L+Q + K ++ L V
Sbjct: 1631 KQQ----NQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1686
Query: 1030 DKLSNQKVALEKQIESLSNTPVSNSTM 1056
L Q ++Q+ L V+ +
Sbjct: 1687 RSLEAQVAHADQQLRDLGKFQVATDAL 1713
Score = 48.4 bits (110), Expect = 1e-04
Identities = 100/592 (16%), Positives = 230/592 (38%), Gaps = 41/592 (6%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
D L+ +++ L ++L +S DE L + L E DA + + +++ L+
Sbjct: 213 DILQTPQFQMRRLKKQLAD-ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLN 271
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
EK + L+++N SL + E + CQ +K ++D+
Sbjct: 272 EKQAASPLEPKELEELRDKNESLTM-----------RLHETLKQCQDLKTEKSQMDRKIN 320
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI 695
+ + + L + L E+ + T++ + ++ E +A +
Sbjct: 321 QLSEENGDLSFKLREFASHLQQLQDALNE---LTEEHSKATQEWLEKQAQLEK-ELSAAL 376
Query: 696 QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ 755
Q++ + + +I + KL + E L++L + K + V LE+ ++ L
Sbjct: 377 QDKKCLEEKNEILQG-KLS-QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 434
Query: 756 KDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
++ R+ LE++ R +Q A + DL +
Sbjct: 435 NTQLQARVEMLETE-RGQQEAKLLAERGHFEEEKQQLSSLIT---------DLQSSISNL 484
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
K + S + ++L ++ S EL L ++ D E + +E+ Q A+
Sbjct: 485 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 544
Query: 876 KKEKLSLEQQVSNLKEQIRT--QQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
+++ Q + + EQ+ + +Q ++ + A+ T +D A + + +A +
Sbjct: 545 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER--EASL 602
Query: 934 EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQ 993
+ +K +E L K K++ ++ ++ ++ + + + E EL +
Sbjct: 603 RERDAALKQLEALE------KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 656
Query: 994 RYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN 1053
+ +EL ET + + + Q L E ++ E ++VA EK +
Sbjct: 657 KVEELQACVETARQEQHEAQAQVAEL-ELQLRSEQQKATEKERVAQEKD-QLQEQLQALK 714
Query: 1054 STMYVATGSAIVQNQQITDVMKENQK-LKKMNAKLITICKKRGKTGANRENE 1104
++ V GS + ++ D ++E Q+ + ++ A+ ++ ++ + E E
Sbjct: 715 ESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 766
>AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant 2
protein.
Length = 1715
Score = 60.9 bits (141), Expect = 2e-08
Identities = 143/735 (19%), Positives = 292/735 (39%), Gaps = 63/735 (8%)
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+IK+ K + + L T R L+ Q+ ++ N KD+EI+ L L+ K+ NE
Sbjct: 900 NIKKNKGVKDWPWWKLF--TTVRPLIEVQLSEEQIRN--KDEEIQQLRSKLEKAEKERNE 955
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L+ +D L + I E +E + + + + T + + EK + E + + +
Sbjct: 956 LRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDA--LK 1013
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSELDAGREDCKELCE 261
Q ++ E + + +++N + D + + K E+D ++ ++ E
Sbjct: 1014 KQMEVMEMEVMEARL---IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1070
Query: 262 DFTSI----KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK-RNLNSLSEQLINN 316
D + K LE ++ D +E + + K ++ +E++ L+ +Q+ N+
Sbjct: 1071 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH 1130
Query: 317 ESKK---------------------SKDHIDRYKDSLLA---VLDAEFGTTSLDVFEILM 352
E +K ++ + R KD LLA L + +D+
Sbjct: 1131 ELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ 1190
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + +L +I + +K + L + +L+ + K+ +L E+ +L K
Sbjct: 1191 K--VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1248
Query: 413 ERI----HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
R+ + + ++ ++ E++E KL ++++ + + + ++ L
Sbjct: 1249 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1308
Query: 469 FDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L T +++R D+E EK +LR + KA+ + E ++K+
Sbjct: 1309 EGKLATLSDQVNRRDFESEK-RLRKDLKRTKALLADAQLMLDHLKNSAPSKREI-AQLKN 1366
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
EE + V A I+ L +ID + A EE++ L + N E+ +
Sbjct: 1367 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN---EIQNR 1423
Query: 588 INGLKEENNSLKSLNDVITREKE---TQASELERSCQVIKQNGFEL-DKMKADILMXXXX 643
+ +E+ N L + + Q ++L+ + + EL +K++A
Sbjct: 1424 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL 1483
Query: 644 XXXXXXXXXXXXDEAK-SLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
EAK LE L + Q + SRL+ N+ EK E +++ I
Sbjct: 1484 EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENM---EKLTEERDQRIA 1540
Query: 702 RLQKQIQEDDKLFIE-KETK--LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
++ +++ +L + ++TK + EL K R DLES A L L
Sbjct: 1541 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL 1600
Query: 759 VEGRIAELESDIRTE 773
RI +L++ I E
Sbjct: 1601 AFKRIGDLQAAIEDE 1615
Score = 58.4 bits (135), Expect = 1e-07
Identities = 91/407 (22%), Positives = 167/407 (41%), Gaps = 31/407 (7%)
Query: 656 DEAKSLLEQNLALKEQCEEKTR-DCSRLEINIK--THEKTAEIQNRMIMRLQKQIQEDDK 712
DE L L E+ + R + RLE I T E T E + ++
Sbjct: 936 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 995
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSR----EAVNQLTTQKDLVEGRIAELES 768
L EKE K EL +Y+ALK+ + ++ +R +N D + E
Sbjct: 996 LRAEKEMK--ELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYER 1053
Query: 769 DIR-TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+R + T GD D E+ + K+ ++
Sbjct: 1054 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT- 1112
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ K L Q +L+++ + D E E Q Q +L++EK L +
Sbjct: 1113 AELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAF 1172
Query: 888 NLKEQIR---------TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+LK+Q+ TQ+ V +A+ D++ +D A+L V +A+V+ +
Sbjct: 1173 SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE- 1231
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELE-ELKQRYK 996
+ ++E Q L+ +++ ME+ + KE E++ +E+E+ + + +LKQ
Sbjct: 1232 --EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1289
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+L+EE E KQ+ + KR E K+A + D+++ + EK++
Sbjct: 1290 QLEEEYED-----KQKVLREKRELEGKLA-TLSDQVNRRDFESEKRL 1330
Score = 56.0 bits (129), Expect = 7e-07
Identities = 136/719 (18%), Positives = 287/719 (39%), Gaps = 47/719 (6%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
+ K + + +E+ +++ ++E TSEL S SQL++ E A LR +KE +
Sbjct: 946 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA-SQLLDAETA-ERLRAEKE-M 1002
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ 475
E+ + D +KK+ E+ E+ E + +I+ ++D D A + + ++ + +
Sbjct: 1003 KELQTQY--DALKKQMEVMEMEVMEARLIRAAEIN--GEVDDD-DAGGEWRLKYERAVRE 1057
Query: 476 YELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL-- 532
+ ++ + E ++KL +E + + L++ + + L EL
Sbjct: 1058 VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 1117
Query: 533 TKLYKSKVDENNANLNL--------IKILSEEIDALKIAIAK-NEEKMLSLSEK---DNK 580
TKL+ N L + EE K+ K EK + L+E +
Sbjct: 1118 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1177
Query: 581 LTELVSTINGLKEENNSLKS-LNDVITREKETQASELERSCQV------IKQNGFELDKM 633
L E I G ++ SL++ L D+ ++E + +AS + Q+ +K ELD+
Sbjct: 1178 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1237
Query: 634 KADILMXXXXXXXXXXXXX----XXXDEAKSLLEQNLALKEQCEEKTRDCS-RLEINIKT 688
I M E +S E+ ++ C++K + +LE +
Sbjct: 1238 AGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1297
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
+K + + +L + ++ E E +L + + +AL D + L++S +
Sbjct: 1298 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS 1357
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
++ K+ +E + ++ + V R+
Sbjct: 1358 KREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREK 1417
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E + + ++ + + + + Q ++DL+ + +E + E + E LQ
Sbjct: 1418 NEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ-INDLQAQLEEANKEKQELQEKLQAL 1476
Query: 869 DEQCARLKK---EKLSLEQQVSNLKEQIRTQQPVER-QAK-FADVAVNTDEDWANLHSVV 923
Q L++ +K + +Q + ++E + T+ ER Q K +A E+ L
Sbjct: 1477 QSQVEFLEQSMVDKSLVSRQEAKIRE-LETRLEFERTQVKRLESLASRLKENMEKLTEER 1535
Query: 924 VDRMSYD-AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R++ + E E+NKRL + +LR K+++ K +A K + + + E+ +
Sbjct: 1536 DQRIAAENREKEQNKRLQR---QLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQ 1592
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
+A+L+ +R +L E E + E+ ++ + E+ D++ K L K
Sbjct: 1593 SLQADLKLAFKRIGDLQAAIEDEME-SDENEDLINSEGDSDVDSELEDRVDGVKSWLSK 1650
Score = 51.2 bits (117), Expect = 2e-05
Identities = 74/292 (25%), Positives = 130/292 (44%), Gaps = 38/292 (13%)
Query: 827 DSEVSQLKERLLSCQQELDDLK-----------ERYKELDDECETCAEYLQERDEQCA-- 873
D E+ QL+ +L ++E ++L+ E EL DE T Q D + A
Sbjct: 936 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 995
Query: 874 -RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VN---TDEDWANLHSVVVDRMS 928
R +KE L+ Q LK+Q+ + +A+ A +N D+D + +R
Sbjct: 996 LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAV 1055
Query: 929 YDAEVEKNKRLMKTIE-----ELRYKKQ------DLKNTVTKMQKAMEKYTKKDKEFEAK 977
+ + K KRL + E E + K+Q DL+ + Q+A+++ KK + A
Sbjct: 1056 REVDFTK-KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA- 1113
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR--LKEAKIALEIVDKLSNQ 1035
EL+D K LE + R EL+++ L Q E+ +R L+ K+ E D L +
Sbjct: 1114 --ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE-KDMLLAE 1170
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+L++Q+E + ++ T V + A +Q+ + K+ L K+ +L
Sbjct: 1171 AFSLKQQLEE-KDMDIAGFTQKVVSLEAELQDIS-SQESKDEASLAKVKKQL 1220
Score = 49.2 bits (112), Expect = 8e-05
Identities = 104/526 (19%), Positives = 208/526 (39%), Gaps = 38/526 (7%)
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
L++ R K+ + +L + ++ EL ++ +D L E+ S
Sbjct: 927 LSEEQIRNKDEEIQQLRSKLEKAEKERNEL-RLNSDRLESRISELTSELTDERNTGESAS 985
Query: 661 -LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
LL+ A + + E++ ++ L+ +K E+ +M + + ++ +
Sbjct: 986 QLLDAETAERLRAEKEMKE---LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDD 1042
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVEGRIAELESDIRTEQTATV 778
E KYE R+ D K L+ E ++ Q K +E R+ +L++D +E++
Sbjct: 1043 AGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQAD--SEESQRA 1100
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
G + R N +L+ +R DSE+SQ E
Sbjct: 1101 LQQLKKKCQRLTAELQDTKLHLEGQQVR----NHELEKKQRRF-----DSELSQAHEEAQ 1151
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ- 897
+ + + L+ L E + + L+E+D A ++ +SLE ++ ++ Q +
Sbjct: 1152 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1211
Query: 898 ---PVERQ-----AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRY 948
V++Q AK D DE + + ++ + E+E+ ++ K +E
Sbjct: 1212 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1271
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
+ ++ + + K K ME + ++E+E K+K L + K ELE D+ E
Sbjct: 1272 EVEEARQSCQKKLKQME--VQLEEEYEDKQKVLRE-KRELEGKLATLS--DQVNRRDFES 1326
Query: 1009 LKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESLSN-TPVSNSTMYVATGSAIVQ 1066
K+ + KR K ++ +D L N + +++I L N S T A +
Sbjct: 1327 EKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVKARKAM 1385
Query: 1067 NQQITDVMKENQKLKKMNAKL---ITICKKRGKTGANRENEDPSDV 1109
+I D+ + + K L ++ ++ NR ED D+
Sbjct: 1386 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM 1431
Score = 48.4 bits (110), Expect = 1e-04
Identities = 98/493 (19%), Positives = 218/493 (44%), Gaps = 59/493 (11%)
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEIN-----IKTHEKTAEIQNRMIMRL------- 703
+E++ L+Q LK++C+ T + +++ ++ HE + Q R L
Sbjct: 1095 EESQRALQQ---LKKKCQRLTAELQDTKLHLEGQQVRNHELEKK-QRRFDSELSQAHEEA 1150
Query: 704 QKQIQEDDKLFIEKETKLNELTN-KYEALKRDYDAA--VKDLESSREAVNQLTTQKDLVE 760
Q++ + +KL EK+ L E + K + ++D D A + + S + +++Q+ E
Sbjct: 1151 QREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE 1210
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLDDSPK 819
+A+++ +R + E + + + K +S
Sbjct: 1211 ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD 1270
Query: 820 RSISVISDSEVSQLKERLLSCQQELDD----LKERYKELDDECETCAEYLQERD-EQCAR 874
+ S +LK+ + ++E +D L+E+ +EL+ + T ++ + RD E R
Sbjct: 1271 EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK-RELEGKLATLSDQVNRRDFESEKR 1329
Query: 875 LKKEKLSLEQQVSNLK---EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+K+ + +++ + + ++ P +R+ A + +E + V R + +
Sbjct: 1330 LRKDLKRTKALLADAQLMLDHLKNSAPSKRE--IAQLKNQLEESEFTCAAAVKARKAMEV 1387
Query: 932 EVE----------KNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK- 979
E+E K K L + + L+ +K +++N + + Q+ M + KK K A+
Sbjct: 1388 EIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASR 1447
Query: 980 ---ELEDCKAELEELKQRYKELDEECETC---AEYLKQR--EEQCKRLKEAKIALEIVDK 1031
++ D +A+LEE + +EL E+ + E+L+Q ++ +EAKI E+ +
Sbjct: 1448 DLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR-ELETR 1506
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITIC 1091
L ++ + K++ESL++ N ++Q+I +E ++ K++ +L
Sbjct: 1507 LEFERTQV-KRLESLASRLKENMEKLTEE-----RDQRIAAENREKEQNKRLQRQLRDTK 1560
Query: 1092 KKRGKTGANRENE 1104
++ G+ A +E E
Sbjct: 1561 EEMGEL-ARKEAE 1572
Score = 44.8 bits (101), Expect = 0.002
Identities = 58/280 (20%), Positives = 127/280 (45%), Gaps = 32/280 (11%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLL--------MSQI 112
QS ++ ++ ++LE+ + + +K LEGK L + RD + +
Sbjct: 1278 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT 1337
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN---VTESDNLNKEVD 169
K+L + +KN S + ++ N+L+E T + + E ++L+ ++D
Sbjct: 1338 KALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID 1397
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS 229
D+ K L ++ L++ NE +N++ +E++ N L K +++
Sbjct: 1398 DIAKAKTALEEQLSRLQREKNEIQNRLEED--------QEDM---------NELMKKHKA 1440
Query: 230 ISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMD--LDEKLGE 287
+ + S +I LQ++L+ ++ +EL E ++++ +E E +M + + +
Sbjct: 1441 -AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK 1499
Query: 288 NNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDR 327
E ET+ +++KR L SL+ +L N K +++ R
Sbjct: 1500 IRELETRLEFERTQVKR-LESLASRLKENMEKLTEERDQR 1538
Score = 36.3 bits (80), Expect = 0.61
Identities = 67/383 (17%), Positives = 165/383 (43%), Gaps = 26/383 (6%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI-KSLEMENLTKDKEIK 127
++ K ++L+ EL D K + + L + + D +SQ + + E L ++K ++
Sbjct: 1103 QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK-LQ 1161
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC----LTQKCI 183
D L ++ + + EE D + V + +++ + +E + ++
Sbjct: 1162 REKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1221
Query: 184 DLEKLVNESENKI----GPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
DLE V + E ++ G + Q KL+ E ++ + + + + + ++ S +
Sbjct: 1222 DLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQ 1281
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K+ ++ +L+ ED +++ + K LE ++ ++ + E+ + K +K
Sbjct: 1282 -KKLKQMEVQLEEEYEDKQKVLRE----KRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1336
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ + + + L N S SK I + K+ L ++EF + M+ I
Sbjct: 1337 TKALLADAQLMLDHLKN--SAPSKREIAQLKNQL---EESEFTCAAAVKARKAMEVEIED 1391
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE--KENACNILRIQKE--R 414
+ +D+I + T ++ L+ E + +L + E K++ + + ++ +
Sbjct: 1392 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1451
Query: 415 IHEISSAVTIDIVKKENELKEIL 437
I+++ + + + K++ EL+E L
Sbjct: 1452 INDLQAQLE-EANKEKQELQEKL 1473
Score = 33.1 bits (72), Expect = 5.7
Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 933 VEKNKRLMKTIEELRYKKQ-DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
V+KN + K +++ + K + ++Q + E+ KD+E + R +LE + E EL
Sbjct: 897 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNEL 956
Query: 992 KQRYKELDEE-CETCAEYLKQRE--EQCKRLKEAKIALEI-----VDKLSNQKVALEKQI 1043
+ L+ E +E +R E +L +A+ A + + +L Q AL+KQ+
Sbjct: 957 RLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM 1016
Query: 1044 E 1044
E
Sbjct: 1017 E 1017
>AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant 1
protein.
Length = 2046
Score = 60.9 bits (141), Expect = 2e-08
Identities = 143/735 (19%), Positives = 292/735 (39%), Gaps = 63/735 (8%)
Query: 83 DIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINE 142
+IK+ K + + L T R L+ Q+ ++ N KD+EI+ L L+ K+ NE
Sbjct: 1216 NIKKNKGVKDWPWWKLF--TTVRPLIEVQLSEEQIRN--KDEEIQQLRSKLEKAEKERNE 1271
Query: 143 LQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNIC 202
L+ +D L + I E +E + + + + T + + EK + E + + +
Sbjct: 1272 LRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDA--LK 1329
Query: 203 AQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSELDAGREDCKELCE 261
Q ++ E + + +++N + D + + K E+D ++ ++ E
Sbjct: 1330 KQMEVMEMEVMEARL---IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFE 1386
Query: 262 DFTSI----KNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK-RNLNSLSEQLINN 316
D + K LE ++ D +E + + K ++ +E++ L+ +Q+ N+
Sbjct: 1387 DKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNH 1446
Query: 317 ESKK---------------------SKDHIDRYKDSLLA---VLDAEFGTTSLDVFEILM 352
E +K ++ + R KD LLA L + +D+
Sbjct: 1447 ELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQ 1506
Query: 353 DNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQK 412
+ + +L +I + +K + L + +L+ + K+ +L E+ +L K
Sbjct: 1507 K--VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1564
Query: 413 ERI----HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITIL 468
R+ + + ++ ++ E++E KL ++++ + + + ++ L
Sbjct: 1565 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1624
Query: 469 FDALIT-QYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS 527
L T +++R D+E EK +LR + KA+ + E ++K+
Sbjct: 1625 EGKLATLSDQVNRRDFESEK-RLRKDLKRTKALLADAQLMLDHLKNSAPSKREI-AQLKN 1682
Query: 528 LHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
EE + V A I+ L +ID + A EE++ L + N E+ +
Sbjct: 1683 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN---EIQNR 1739
Query: 588 INGLKEENNSLKSLNDVITREKE---TQASELERSCQVIKQNGFEL-DKMKADILMXXXX 643
+ +E+ N L + + Q ++L+ + + EL +K++A
Sbjct: 1740 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL 1799
Query: 644 XXXXXXXXXXXXDEAK-SLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIM 701
EAK LE L + Q + SRL+ N+ EK E +++ I
Sbjct: 1800 EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENM---EKLTEERDQRIA 1856
Query: 702 RLQKQIQEDDKLFIE-KETK--LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
++ +++ +L + ++TK + EL K R DLES A L L
Sbjct: 1857 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL 1916
Query: 759 VEGRIAELESDIRTE 773
RI +L++ I E
Sbjct: 1917 AFKRIGDLQAAIEDE 1931
Score = 58.4 bits (135), Expect = 1e-07
Identities = 91/407 (22%), Positives = 167/407 (41%), Gaps = 31/407 (7%)
Query: 656 DEAKSLLEQNLALKEQCEEKTR-DCSRLEINIK--THEKTAEIQNRMIMRLQKQIQEDDK 712
DE L L E+ + R + RLE I T E T E + ++
Sbjct: 1252 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 1311
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSR----EAVNQLTTQKDLVEGRIAELES 768
L EKE K EL +Y+ALK+ + ++ +R +N D + E
Sbjct: 1312 LRAEKEMK--ELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYER 1369
Query: 769 DIR-TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISD 827
+R + T GD D E+ + K+ ++
Sbjct: 1370 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT- 1428
Query: 828 SEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVS 887
+E+ K L Q +L+++ + D E E Q Q +L++EK L +
Sbjct: 1429 AELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAF 1488
Query: 888 NLKEQIR---------TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKR 938
+LK+Q+ TQ+ V +A+ D++ +D A+L V +A+V+ +
Sbjct: 1489 SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE- 1547
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTK-KDKEFEAKRKELEDCKAELE-ELKQRYK 996
+ ++E Q L+ +++ ME+ + KE E++ +E+E+ + + +LKQ
Sbjct: 1548 --EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1605
Query: 997 ELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQI 1043
+L+EE E KQ+ + KR E K+A + D+++ + EK++
Sbjct: 1606 QLEEEYED-----KQKVLREKRELEGKLA-TLSDQVNRRDFESEKRL 1646
Score = 53.2 bits (122), Expect = 5e-06
Identities = 129/681 (18%), Positives = 272/681 (39%), Gaps = 46/681 (6%)
Query: 356 INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
+ K + + +E+ +++ ++E TSEL S SQL++ E A LR +KE +
Sbjct: 1262 LEKAEKERNELRLNSDRLESRISELTSELTDERNTGESA-SQLLDAETA-ERLRAEKE-M 1318
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQ 475
E+ + D +KK+ E+ E+ E + +I+ ++D D A + + ++ + +
Sbjct: 1319 KELQTQY--DALKKQMEVMEMEVMEARLIRAAEIN--GEVDDD-DAGGEWRLKYERAVRE 1373
Query: 476 YELSRTDYEIE-KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEEL-- 532
+ ++ + E ++KL +E + + L++ + + L EL
Sbjct: 1374 VDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 1433
Query: 533 TKLYKSKVDENNANLNL--------IKILSEEIDALKIAIAK-NEEKMLSLSEK---DNK 580
TKL+ N L + EE K+ K EK + L+E +
Sbjct: 1434 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1493
Query: 581 LTELVSTINGLKEENNSLKS-LNDVITREKETQASELERSCQV------IKQNGFELDKM 633
L E I G ++ SL++ L D+ ++E + +AS + Q+ +K ELD+
Sbjct: 1494 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1553
Query: 634 KADILMXXXXXXXXXXXXX----XXXDEAKSLLEQNLALKEQCEEKTRDCS-RLEINIKT 688
I M E +S E+ ++ C++K + +LE +
Sbjct: 1554 AGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1613
Query: 689 HEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREA 748
+K + + +L + ++ E E +L + + +AL D + L++S +
Sbjct: 1614 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS 1673
Query: 749 VNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDL 808
++ K+ +E + ++ + V R+
Sbjct: 1674 KREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREK 1733
Query: 809 GENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQER 868
E + + ++ + + + + Q ++DL+ + +E + E + E LQ
Sbjct: 1734 NEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ-INDLQAQLEEANKEKQELQEKLQAL 1792
Query: 869 DEQCARLKK---EKLSLEQQVSNLKEQIRTQQPVER-QAK-FADVAVNTDEDWANLHSVV 923
Q L++ +K + +Q + ++E + T+ ER Q K +A E+ L
Sbjct: 1793 QSQVEFLEQSMVDKSLVSRQEAKIRE-LETRLEFERTQVKRLESLASRLKENMEKLTEER 1851
Query: 924 VDRMSYD-AEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE 982
R++ + E E+NKRL + +LR K+++ K +A K + + + E+ +
Sbjct: 1852 DQRIAAENREKEQNKRLQR---QLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQ 1908
Query: 983 DCKAELEELKQRYKELDEECE 1003
+A+L+ +R +L E
Sbjct: 1909 SLQADLKLAFKRIGDLQAAIE 1929
Score = 51.2 bits (117), Expect = 2e-05
Identities = 74/292 (25%), Positives = 130/292 (44%), Gaps = 38/292 (13%)
Query: 827 DSEVSQLKERLLSCQQELDDLK-----------ERYKELDDECETCAEYLQERDEQCA-- 873
D E+ QL+ +L ++E ++L+ E EL DE T Q D + A
Sbjct: 1252 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 1311
Query: 874 -RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVA-VN---TDEDWANLHSVVVDRMS 928
R +KE L+ Q LK+Q+ + +A+ A +N D+D + +R
Sbjct: 1312 LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAV 1371
Query: 929 YDAEVEKNKRLMKTIE-----ELRYKKQ------DLKNTVTKMQKAMEKYTKKDKEFEAK 977
+ + K KRL + E E + K+Q DL+ + Q+A+++ KK + A
Sbjct: 1372 REVDFTK-KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA- 1429
Query: 978 RKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR--LKEAKIALEIVDKLSNQ 1035
EL+D K LE + R EL+++ L Q E+ +R L+ K+ E D L +
Sbjct: 1430 --ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE-KDMLLAE 1486
Query: 1036 KVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
+L++Q+E + ++ T V + A +Q+ + K+ L K+ +L
Sbjct: 1487 AFSLKQQLEE-KDMDIAGFTQKVVSLEAELQDIS-SQESKDEASLAKVKKQL 1536
Score = 49.2 bits (112), Expect = 8e-05
Identities = 104/526 (19%), Positives = 208/526 (39%), Gaps = 38/526 (7%)
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
L++ R K+ + +L + ++ EL ++ +D L E+ S
Sbjct: 1243 LSEEQIRNKDEEIQQLRSKLEKAEKERNEL-RLNSDRLESRISELTSELTDERNTGESAS 1301
Query: 661 -LLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKET 719
LL+ A + + E++ ++ L+ +K E+ +M + + ++ +
Sbjct: 1302 QLLDAETAERLRAEKEMKE---LQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDD 1358
Query: 720 KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-KDLVEGRIAELESDIRTEQTATV 778
E KYE R+ D K L+ E ++ Q K +E R+ +L++D +E++
Sbjct: 1359 AGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQAD--SEESQRA 1416
Query: 779 XXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLL 838
G + R N +L+ +R DSE+SQ E
Sbjct: 1417 LQQLKKKCQRLTAELQDTKLHLEGQQVR----NHELEKKQRRF-----DSELSQAHEEAQ 1467
Query: 839 SCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQ- 897
+ + + L+ L E + + L+E+D A ++ +SLE ++ ++ Q +
Sbjct: 1468 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1527
Query: 898 ---PVERQ-----AKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRY 948
V++Q AK D DE + + ++ + E+E+ ++ K +E
Sbjct: 1528 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1587
Query: 949 KKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEY 1008
+ ++ + + K K ME + ++E+E K+K L + K ELE D+ E
Sbjct: 1588 EVEEARQSCQKKLKQME--VQLEEEYEDKQKVLRE-KRELEGKLATLS--DQVNRRDFES 1642
Query: 1009 LKQREEQCKRLKEAKIALEI-VDKLSNQKVALEKQIESLSN-TPVSNSTMYVATGSAIVQ 1066
K+ + KR K ++ +D L N + +++I L N S T A +
Sbjct: 1643 EKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVKARKAM 1701
Query: 1067 NQQITDVMKENQKLKKMNAKL---ITICKKRGKTGANRENEDPSDV 1109
+I D+ + + K L ++ ++ NR ED D+
Sbjct: 1702 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM 1747
Score = 48.4 bits (110), Expect = 1e-04
Identities = 98/493 (19%), Positives = 218/493 (44%), Gaps = 59/493 (11%)
Query: 656 DEAKSLLEQNLALKEQCEEKTRDCSRLEIN-----IKTHEKTAEIQNRMIMRL------- 703
+E++ L+Q LK++C+ T + +++ ++ HE + Q R L
Sbjct: 1411 EESQRALQQ---LKKKCQRLTAELQDTKLHLEGQQVRNHELEKK-QRRFDSELSQAHEEA 1466
Query: 704 QKQIQEDDKLFIEKETKLNELTN-KYEALKRDYDAA--VKDLESSREAVNQLTTQKDLVE 760
Q++ + +KL EK+ L E + K + ++D D A + + S + +++Q+ E
Sbjct: 1467 QREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE 1526
Query: 761 GRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE-NPKLDDSPK 819
+A+++ +R + E + + + K +S
Sbjct: 1527 ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD 1586
Query: 820 RSISVISDSEVSQLKERLLSCQQELDD----LKERYKELDDECETCAEYLQERD-EQCAR 874
+ S +LK+ + ++E +D L+E+ +EL+ + T ++ + RD E R
Sbjct: 1587 EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK-RELEGKLATLSDQVNRRDFESEKR 1645
Query: 875 LKKEKLSLEQQVSNLK---EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+K+ + +++ + + ++ P +R+ A + +E + V R + +
Sbjct: 1646 LRKDLKRTKALLADAQLMLDHLKNSAPSKRE--IAQLKNQLEESEFTCAAAVKARKAMEV 1703
Query: 932 EVE----------KNKR-LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRK- 979
E+E K K L + + L+ +K +++N + + Q+ M + KK K A+
Sbjct: 1704 EIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASR 1763
Query: 980 ---ELEDCKAELEELKQRYKELDEECETC---AEYLKQR--EEQCKRLKEAKIALEIVDK 1031
++ D +A+LEE + +EL E+ + E+L+Q ++ +EAKI E+ +
Sbjct: 1764 DLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR-ELETR 1822
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITIC 1091
L ++ + K++ESL++ N ++Q+I +E ++ K++ +L
Sbjct: 1823 LEFERTQV-KRLESLASRLKENMEKLTEE-----RDQRIAAENREKEQNKRLQRQLRDTK 1876
Query: 1092 KKRGKTGANRENE 1104
++ G+ A +E E
Sbjct: 1877 EEMGEL-ARKEAE 1888
Score = 46.8 bits (106), Expect = 4e-04
Identities = 80/415 (19%), Positives = 182/415 (43%), Gaps = 56/415 (13%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLL--------MSQI 112
QS ++ ++ ++LE+ + + +K LEGK L + RD + +
Sbjct: 1594 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT 1653
Query: 113 KSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMEN---VTESDNLNKEVD 169
K+L + +KN S + ++ N+L+E T + + E ++L+ ++D
Sbjct: 1654 KALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID 1713
Query: 170 DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRS 229
D+ K L ++ L++ NE +N++ +E++ N L K +++
Sbjct: 1714 DIAKAKTALEEQLSRLQREKNEIQNRLEED--------QEDM---------NELMKKHKA 1756
Query: 230 ISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENN 289
+ + S +I LQ++L+ ++ +EL E ++++ +E E +M +D+ L
Sbjct: 1757 -AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSM---VDKSLVSRQ 1812
Query: 290 EFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFE 349
E + + ++ E +R E L + K++ + + +D +A + E
Sbjct: 1813 EAKIRELETRLEFERTQVKRLESLA-SRLKENMEKLTEERDQRIAAENREKEQNK----- 1866
Query: 350 ILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
+ + + ++ E+ K + +E +L+S+ SL + L+
Sbjct: 1867 -RLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQAD----------LK 1915
Query: 410 IQKERIHEISSAVTIDIVKKENE-----LKEILTKECLKLSKLKIDIPRDLDQDL 459
+ +RI ++ +A+ ++ ENE L++++TK + +KL+ D D+D +L
Sbjct: 1916 LAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGD--SDVDSEL 1968
Score = 40.3 bits (90), Expect = 0.037
Identities = 106/585 (18%), Positives = 249/585 (42%), Gaps = 44/585 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQI-KSLEMENLTKDKEIK 127
++ K ++L+ EL D K + + L + + D +SQ + + E L ++K ++
Sbjct: 1419 QLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK-LQ 1477
Query: 128 NLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC----LTQKCI 183
D L ++ + + EE D + V + +++ + +E + ++
Sbjct: 1478 REKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1537
Query: 184 DLEKLVNESENKI----GPKNICAQCKLK-ENLIQSLHIGYDNTLSKLNRSISDSNTSTR 238
DLE V + E ++ G + Q KL+ E ++ + + + + + ++ S +
Sbjct: 1538 DLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQ 1597
Query: 239 YNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKV 298
K+ ++ +L+ ED +++ + K LE ++ ++ + E+ + K +K
Sbjct: 1598 -KKLKQMEVQLEEEYEDKQKVLRE----KRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1652
Query: 299 MSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINK 358
+ + + + L N S SK I + K+ L ++EF + M+ I
Sbjct: 1653 TKALLADAQLMLDHLKN--SAPSKREIAQLKNQL---EESEFTCAAAVKARKAMEVEIED 1707
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE--KENACNILRIQKE--R 414
+ +D+I + T ++ L+ E + +L + E K++ + + ++ +
Sbjct: 1708 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1767
Query: 415 IHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALIT 474
I+++ + + + K++ EL+E L + L+ S+++ +D+ L + ++ I L T
Sbjct: 1768 INDLQAQLE-EANKEKQELQEKL--QALQ-SQVEFLEQSMVDKSLVSRQEAKI--RELET 1821
Query: 475 QYELSRTDYE-IEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELT 533
+ E RT + +E RL+ K + + + +++ EE+
Sbjct: 1822 RLEFERTQVKRLESLASRLKENMEK-LTEERDQRIAAENREKEQNKRLQRQLRDTKEEMG 1880
Query: 534 KLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKE 593
+L + + + + L E+D L+ A N+ L ++ +L + I E
Sbjct: 1881 ELARKEAEASRKKHEL------EMD-LESLEAANQSLQADLKLAFKRIGDLQAAIEDEME 1933
Query: 594 --ENNSL-KSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
EN L SL D++T+ ++ + ++LE V + +D +K+
Sbjct: 1934 SDENEDLINSLQDMVTKYQK-RKNKLEGDSDVDSELEDRVDGVKS 1977
Score = 33.1 bits (72), Expect = 5.7
Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 933 VEKNKRLMKTIEELRYKKQ-DLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEEL 991
V+KN + K +++ + K + ++Q + E+ KD+E + R +LE + E EL
Sbjct: 1213 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNEL 1272
Query: 992 KQRYKELDEE-CETCAEYLKQRE--EQCKRLKEAKIALEI-----VDKLSNQKVALEKQI 1043
+ L+ E +E +R E +L +A+ A + + +L Q AL+KQ+
Sbjct: 1273 RLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM 1332
Query: 1044 E 1044
E
Sbjct: 1333 E 1333
>BC056146-1|AAH56146.1| 718|Homo sapiens hook homolog 3
(Drosophila) protein.
Length = 718
Score = 60.5 bits (140), Expect = 3e-08
Identities = 84/403 (20%), Positives = 173/403 (42%), Gaps = 41/403 (10%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK 85
++ + +ND + L+D I + + + ++ +KL +L D++
Sbjct: 278 EISELRQQNDELTTLADEAQSLKDE--IDVLRHSSDKVSKLEGQVESYKKKLE-DLGDLR 334
Query: 86 EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
Q LE K + T + + + + + + T +++ L + L +SKK ++L
Sbjct: 335 RQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDF 394
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE--KLVNESENKIGPK---- 199
E L + E D L E D LK+ E L +C+ + +L + +G +
Sbjct: 395 EYKRLKEKVDSLQKEKDRLRTERDSLKETIEEL--RCVQAQEGQLTTQGLMPLGSQESSD 452
Query: 200 NICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKEL 259
++ A+ E + + + ++N + KLN+ SD+ KI LQS LD EL
Sbjct: 453 SLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDN------EKIALLQSLLDDANLRKNEL 506
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E + N L + +L + L + +V + +++ +L L E NNE +
Sbjct: 507 -ETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHE--ANNELQ 563
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K K +++ L+ F +SL + E + + K + ++ ++ E+Y K L +
Sbjct: 564 K--------KRAIIEDLEPRFNNSSLKIEE--LQEALRKKEEEMKQMEERYKKY---LEK 610
Query: 380 CTSELKSVNEK--------LASLNSQLIEKENACNILRIQKER 414
S +++++ K + +L +QL E++ + L + E+
Sbjct: 611 AKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEK 653
Score = 58.8 bits (136), Expect = 1e-07
Identities = 95/510 (18%), Positives = 208/510 (40%), Gaps = 27/510 (5%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
E + V + +EL N+A ++L + L + + L A++ EE E D
Sbjct: 144 ESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELD 203
Query: 579 NKLTELVSTINGLKEENNSL-KSLNDVITREKETQAS-----ELERSCQVIKQNGFELDK 632
++ L + L EN L + LN + E + +L+ + +++ F L+
Sbjct: 204 MQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEA 263
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCE---EKTRDCSRLEINIKTH 689
K D + DE +L ++ +LK++ + + S+LE ++++
Sbjct: 264 AKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESY 323
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+K E + R K ++E + ++++ L E K A + + + + + +
Sbjct: 324 KKKLEDLGD-LRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRL 382
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
++ + + D ++ L+ + + Q G G
Sbjct: 383 SEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQ-G 441
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
P S + S S+ ++ +++E+L+ Q E LK + D+E + L +
Sbjct: 442 LMPL--GSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDD- 498
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS- 928
A L+K +L E ++ N + + Q VE K + ED L + + +
Sbjct: 499 ---ANLRKNELETENRLVN-QRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
Query: 929 -YDA--EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDC 984
++A E++K + +++ +E R+ LK + ++Q+A+ K ++ K+ E + +K LE
Sbjct: 555 LHEANNELQKKRAIIEDLEP-RFNNSSLK--IEELQEALRKKEEEMKQMEERYKKYLEKA 611
Query: 985 KAELEELKQRYKE-LDEECETCAEYLKQRE 1013
K+ + L + + E + L++R+
Sbjct: 612 KSVIRTLDPKQNQGAAPEIQALKNQLQERD 641
Score = 57.6 bits (133), Expect = 2e-07
Identities = 101/503 (20%), Positives = 201/503 (39%), Gaps = 43/503 (8%)
Query: 571 MLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFEL 630
M ++ E +K + + + + + + LK + + E + E+ + C + L
Sbjct: 151 MTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELN-EALSAKEEIAQRCHELDMQVAAL 209
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+ K+ +L D ++L L+ Q E+ + RLE +
Sbjct: 210 QEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYR 269
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
E L+K+I E ++ +L L ++ ++LK + D + +
Sbjct: 270 IRCE-------ELEKEISE----LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEG 318
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q+ + K +E + +L ++ + R + E
Sbjct: 319 QVESYKKKLED-LGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVE 377
Query: 811 -NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
+L + K++ + D E +LKE++ S Q+E D L+ L + E +Q ++
Sbjct: 378 LQNRLSEESKKADKL--DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEEL-RCVQAQE 434
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD----VAVNTD----EDWANLHS 921
Q L ++ +L +I T + E+ + + +N + E A L S
Sbjct: 435 GQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQS 494
Query: 922 VVVDRMSYDAEVEK-----NKRLMKT---IEELRYKKQD----LKNTVT---KMQKAMEK 966
++ D E+E N+RL++ +EEL+ QD +++V K+++ +EK
Sbjct: 495 LLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR-LKEAKIA 1025
+ + E + KR +ED + + +EL E E +KQ EE+ K+ L++AK
Sbjct: 555 LHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSV 614
Query: 1026 LEIVDKLSNQKVALEKQIESLSN 1048
+ +D NQ A E I++L N
Sbjct: 615 IRTLDPKQNQGAAPE--IQALKN 635
Score = 44.8 bits (101), Expect = 0.002
Identities = 51/244 (20%), Positives = 110/244 (45%), Gaps = 12/244 (4%)
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANL-HSV 922
L++ E+ RL+ K + L+++I +Q + AD A + ++ L HS
Sbjct: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSS 310
Query: 923 VVDRMS-YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
D++S + +VE K+ ++ + +LR + + L+ T + ++ ++ A R +L
Sbjct: 311 --DKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQL 368
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E K ++ EL+ R E ++ + K+ +E+ L++ K D+L ++ +L++
Sbjct: 369 ETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEK------DRLRTERDSLKE 422
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANR 1101
IE L + G + +Q+ +D + ++ KLI + + N+
Sbjct: 423 TIEELRCVQAQEGQL-TTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQ 481
Query: 1102 ENED 1105
E D
Sbjct: 482 EGSD 485
Score = 40.7 bits (91), Expect = 0.028
Identities = 96/477 (20%), Positives = 192/477 (40%), Gaps = 41/477 (8%)
Query: 61 QSLKESSNEINLKL---EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM 117
+ LK+++ E+N L E+++ ++ Q +AL+ + +L+ E Q ++Q S+E
Sbjct: 176 RQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIED 235
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
N + L L+ +LQEE L + + L KE+ +L++ N+
Sbjct: 236 PNSPAGRRHLQLQTQLE-------QLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDE 288
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI---SDSN 234
LT + + L +E + ++ + E ++S ++ L L R + + N
Sbjct: 289 LTTLADEAQSLKDEIDVL---RHSSDKVSKLEGQVESYKKKLED-LGDLRRQVKLLEEKN 344
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETK 294
T N + +L+ EL + ++ LE ++ ++L +L E ++ K
Sbjct: 345 TMYMQNTV-SLEEEL-----------RKANAARSQLETYK-RQVVELQNRLSEESKKADK 391
Query: 295 AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+K ++SL ++ + + +D + + L V E T+ + +
Sbjct: 392 LDFEYKRLKEKVDSLQKE--KDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQE 449
Query: 355 IINKY--QIDLDEILEKYTKVQGDLNEC-TSELKSVNEKLASLNSQLIEKENACNIL--- 408
+ +I EI EK ++Q + ++ S NEK+A L S L + N L
Sbjct: 450 SSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETE 509
Query: 409 -RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
R+ +R+ E+ S V ++ K + L KL+ + + + + KK I
Sbjct: 510 NRLVNQRLLEVQSQVE-ELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAI 568
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D L ++ S E +E LR + K + TL+ N+
Sbjct: 569 IED-LEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ 624
Score = 35.9 bits (79), Expect = 0.80
Identities = 72/360 (20%), Positives = 147/360 (40%), Gaps = 18/360 (5%)
Query: 702 RLQKQIQEDDKLFIEKET---KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+L+K +E ++ KE + +EL + AL+ + + + + + E +NQ + +D
Sbjct: 177 QLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDP 236
Query: 759 ---VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
R +L++ + Q T +N +L
Sbjct: 237 NSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEA 296
Query: 816 DSPKRSISVI--SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
S K I V+ S +VS+L+ ++ S +++L+DL + +++ E Y+Q
Sbjct: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L+K + Q + ++ + Q + ++K AD D ++ L VD + + +
Sbjct: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKAD---KLDFEYKRLKE-KVDSLQKEKDR 412
Query: 934 EKNKR--LMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ +R L +TIEELR + Q+ + T + + + E E+ + L+
Sbjct: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK-VALEKQIESLSNT 1049
+ K E + L Q L+ K LE ++L NQ+ + ++ Q+E L +
Sbjct: 473 ENKMLKLNQEGSDNEKIALLQSLLDDANLR--KNELETENRLVNQRLLEVQSQVEELQKS 530
>AL832009-1|CAD89912.1| 1177|Homo sapiens hypothetical protein
protein.
Length = 1177
Score = 60.5 bits (140), Expect = 3e-08
Identities = 97/406 (23%), Positives = 177/406 (43%), Gaps = 43/406 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E EIN L+K EL +++++ +G+ N L + +L + + LEME KD+
Sbjct: 343 EELEEINKNLQKAEEELQELRDK--IAKGECGNSSLMAEVENL---RKRVLEMEG--KDE 395
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
EI + KK LQEE L + E + L K + +L+K E ++ +
Sbjct: 396 EITKTESQCRELRKK---LQEEEHHSKELRL----EVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 185 LEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+L +N + K K++ + ++ ++ ++ L ++ L K S+ D T + +
Sbjct: 449 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS-ESRLEKAELSLKDDLTKLKSFTV- 506
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
L E E K+ + + ++ E MD+ EKL E ++ K M E
Sbjct: 507 MLVDERKNMMEKIKQEERKVDGLNKNFKV-EQGKVMDVTEKLIEESKKLLKLKSEMEEKV 565
Query: 304 RNLNSLSEQLI---NNESKKSKD---HIDRYKDSLLAVLDAEFGTT---SLDVFEILM-- 352
NL ++LI +E +KS + +D K L + + E T S E+
Sbjct: 566 YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE 625
Query: 353 DNIINKYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
DN I + ++++ + L++ V+GDL + E + +K + +++ N L
Sbjct: 626 DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-------EQDKANFLS 678
Query: 410 IQKERI-HEISSAVTI---DIVKKENELKEILTKECLKLSKLKIDI 451
Q E I H+I+ I ++V +E EL+ E K LK ++
Sbjct: 679 QQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 724
Score = 57.2 bits (132), Expect = 3e-07
Identities = 101/484 (20%), Positives = 216/484 (44%), Gaps = 40/484 (8%)
Query: 280 DLDEKLGENNEFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRY-----KDSLL 333
DL +KL E E + KA+ S E ++ L L + S+ S++H + ++S
Sbjct: 270 DLTQKLREEEE-KLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 328
Query: 334 AVLDAEF-GTTS-LDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKL 391
L + G T ++ E + N+ K + +L E+ +K K + + +E++++ +++
Sbjct: 329 RQLRLKLVGLTQRIEELEEINKNL-QKAEEELQELRDKIAKGECGNSSLMAEVENLRKRV 387
Query: 392 ASL---NSQLIEKENACNILR--IQKERIHEISSAVTIDIVKKE----NELKEILTK--- 439
+ + ++ + E+ C LR +Q+E H + ++ ++K +L+E +K
Sbjct: 388 LEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKS 447
Query: 440 ECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA 499
EC +L L ++ ++L +DL ++ + + + E S + +EK +L L+ K
Sbjct: 448 ECTQLH-LNLEKEKNLTKDLLNELEVV---KSRVKELECSES--RLEKAELSLKDDLTK- 500
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL-----NLIKILS 554
+ + +++ +V L++ K+ + KV + L L+K+ S
Sbjct: 501 LKSFTVMLVDERKNMMEKIKQEERKVDGLNKNF-KVEQGKVMDVTEKLIEESKKLLKLKS 559
Query: 555 EEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
E + + + +E + L ++ K +EL +++ LK+ + ++ + ITR + + S
Sbjct: 560 EMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGS 619
Query: 615 ELE-RSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLA--LKE 670
EL IK+ E++++K + E K EQ+ A L +
Sbjct: 620 ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQ 679
Query: 671 QCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-ETKLNELTNKYE 729
Q EE ++ + K + E + R RL++ D K ++ + K++EL NK +
Sbjct: 680 QLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKED 739
Query: 730 ALKR 733
L +
Sbjct: 740 QLSQ 743
Score = 56.8 bits (131), Expect = 4e-07
Identities = 63/315 (20%), Positives = 136/315 (43%), Gaps = 27/315 (8%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KL + ++ ++ S S+ +++LL + + + R+ + +E L ++
Sbjct: 274 KLREEEEKLKAITSKSKED--RQKLLKLEVDFEHKASRFSQEHEEMNA---KLANQESHN 328
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE--------DWANLHSVVV 924
+L+ + + L Q++ L+E + Q E + + + E + NL V+
Sbjct: 329 RQLRLKLVGLTQRIEELEEINKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 388
Query: 925 DRMSYDAEVEKN----KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ D E+ K + L K ++E + ++L+ V K+QK M + K ++ F + E
Sbjct: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---------IVDK 1031
LE+ K K+L E E +K+ E RL++A+++L+ V
Sbjct: 449 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVML 508
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK-KMNAKLITI 1090
+ +K +EK + N V G + +++ + K+ KLK +M K+ +
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
Query: 1091 CKKRGKTGANRENED 1105
++R + ++E+
Sbjct: 569 TRERDELIGKLKSEE 583
Score = 54.8 bits (126), Expect = 2e-06
Identities = 118/600 (19%), Positives = 242/600 (40%), Gaps = 76/600 (12%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+E + L +EL KL VDE ++ + + S+++ L + + EEK+ +++
Sbjct: 227 KENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAIT 286
Query: 576 EKD----NKLTEL-------VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
K KL +L S + EE N+ + + R+ + L + + ++
Sbjct: 287 SKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE 346
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR---DCSR 681
+ L K + ++ E ++L ++ L ++ + EE T+ C
Sbjct: 347 EINKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRE 406
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L ++ E ++ + +LQK++ E +KL +E T + L+++ + KD
Sbjct: 407 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN-LTKD 465
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L + E V + + E R+ + E ++ + T
Sbjct: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLT-----------------KLKSFTVML 508
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
DE +++ E K ++ ++ + +V + E+L+ ++L LK +
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME------ 562
Query: 859 ETCAEYLQERDEQCARLKKEK---LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDED 915
E +ERDE +LK E+ L V LK+++ + VER ++
Sbjct: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER-----EITRGRSRK 617
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+ L E K K L IE L+ + Q L+ + K ++Y + +++F
Sbjct: 618 GSELTC---------PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFR 668
Query: 976 AKRKELEDCKAELEELKQRY--KELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
++ + +LEE+K + + E+ E ++ + R RL+EAK L
Sbjct: 669 TEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHR--FRLEEAKSR-----DLK 721
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ AL+++I L N S + V +++Q + M+E K K M +++ + K+
Sbjct: 722 AEVQALKEKIHELMNKEDQLSQLQV--DYSVLQQR----FMEEENKNKNMGQEVLNLTKE 775
Score = 51.6 bits (118), Expect = 2e-05
Identities = 147/724 (20%), Positives = 284/724 (39%), Gaps = 81/724 (11%)
Query: 99 ILETQTRDLLMSQIKSLEMENLTKD-KEIKNLTDSLKTKSKKINE---LQEE--NDTLSN 152
+L RD +++Q KS+ + K E+ L + K +++ E L E+ T+
Sbjct: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
Query: 153 LIMENVTESDNLNKEVD--DLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKEN 210
L E +D +NK D +L + +K ++ EK + K K + KL++
Sbjct: 183 LENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLN---KLRDE 239
Query: 211 LIQSLHIG---------YDNTLSKLNRSISDSNTSTRYN--KICTLQSELDAGREDCKEL 259
L++ + L ++ + D R K+ + S+ R+ +L
Sbjct: 240 LVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKL 299
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFE------TKAVKVMSEIKRNLNSLSEQL 313
DF + M L + N + T+ ++ + EI +NL E+L
Sbjct: 300 EVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEEINKNLQKAEEEL 359
Query: 314 INNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL-MDNIINKYQIDLDEILEKYTK 372
K +K SL+ AE V E+ D I K + E+ +K +
Sbjct: 360 QELRDKIAKGECG--NSSLM----AEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQE 413
Query: 373 VQGDLNECTSELKSVNEK---LASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
+ E E++ + ++ L L + ++ C L + E+ ++ + ++
Sbjct: 414 EEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVV 473
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI-LFDALITQYE-LSRTDYEIE- 486
++ +KE+ E +L K ++ L DL K T+ L D E + + + +++
Sbjct: 474 KSRVKELECSES-RLEKAEL----SLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDG 528
Query: 487 -KEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEE-AHNEVKSLHEELTKL--YKSKVDE 542
+ ++E G V +EE +N + E + KL + K E
Sbjct: 529 LNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSE 588
Query: 543 NNANLNLIKILSEEIDALKIAIAKNEEKMLS--LSEKDNKLTELVSTINGLKEENNSLKS 600
+ +++L+K + I+ ++ I + + S +DNK+ EL I LK+ L+
Sbjct: 589 LSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEV 648
Query: 601 LNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKS 660
+ + + E + +LE+ F ++ KA+ L ++ +
Sbjct: 649 VEGDLMK-TEDEYDQLEQK--------FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGE- 698
Query: 661 LLEQNLALKEQC---EEKTRDCSRLEINIKTHEKTAEIQNR--MIMRLQKQIQEDDKLFI 715
++ Q L+ + E K+RD + E+ EK E+ N+ + +LQ + F+
Sbjct: 699 VVSQEAELRHRFRLEEAKSRDL-KAEVQ-ALKEKIHELMNKEDQLSQLQVDYSVLQQRFM 756
Query: 716 EKETK-------LNELTNKYEALKRDYDAAVKDLESSREAVNQLTT----QKDLVEGRIA 764
E+E K + LT + E KR Y A++ + R V+ T Q D V G A
Sbjct: 757 EEENKNKNMGQEVLNLTKELELSKR-YSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAA 815
Query: 765 ELES 768
E E+
Sbjct: 816 EEET 819
Score = 45.2 bits (102), Expect = 0.001
Identities = 125/618 (20%), Positives = 247/618 (39%), Gaps = 53/618 (8%)
Query: 400 EKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDL 459
+ ++ N+L ++ER+ ++ +KE E + L K +L KLK L +
Sbjct: 196 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLK-SFALMLVDER 254
Query: 460 PAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLE 519
H I Q L + +KLR E KA+ E
Sbjct: 255 QMH----------IEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFE 304
Query: 520 EAHNEVKSLHEEL-TKLYKSKVDENNANLNLIKILS--EEIDALKIAIAKNEEKMLSLSE 576
+ HEE+ KL + L L+ + EE++ + + K EE++ L +
Sbjct: 305 HKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEEINKNLQKAEEELQELRD 364
Query: 577 KDNK----LTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDK 632
K K + L++ + L++ ++ ++ IT+ E+Q EL + Q + + EL +
Sbjct: 365 KIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITK-TESQCRELRKKLQEEEHHSKEL-R 422
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRD-CSRLEINIKTHEK 691
++ + L + L NL E+ + T+D + LE+ +K+ K
Sbjct: 423 LEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNL---EKEKNLTKDLLNELEV-VKSRVK 478
Query: 692 TAEIQNRMIMRLQKQIQED-DKLFIEKETKLNELTNKYEALK---RDYDAAVKDLESSRE 747
E + + + +++D KL ++E N E +K R D K+ + +
Sbjct: 479 ELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQG 538
Query: 748 AVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD---E 804
V +T + ++ +L+S++ + D +
Sbjct: 539 KVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKK 598
Query: 805 NRDLGENPKLDDSPKRSI--SVISDSEVSQLKERLLSCQQELDDLKERYKELD----DEC 858
D E + + + RS S ++ E +++KE L E++ LK+R ++L+ D
Sbjct: 599 RLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTL----EIERLKKRLQQLEVVEGDLM 654
Query: 859 ETCAEYLQERDEQCARLKKEKLS-LEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA 917
+T EY ++ EQ R +++K + L QQ+ +K QI + +E+ V + E
Sbjct: 655 KTEDEY--DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKG------EVVSQEAEL 706
Query: 918 NLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK 977
+ + S D + E + L + I EL K+ L +++ +++ + +
Sbjct: 707 RHRFRLEEAKSRDLKAEV-QALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNM 765
Query: 978 RKELEDCKAELEELKQRY 995
+E+ + EL EL +RY
Sbjct: 766 GQEVLNLTKEL-ELSKRY 782
>AF241830-1|AAK29204.1| 718|Homo sapiens golgi-associated
microtubule-binding protein HOOK3 protein.
Length = 718
Score = 60.5 bits (140), Expect = 3e-08
Identities = 84/403 (20%), Positives = 173/403 (42%), Gaps = 41/403 (10%)
Query: 26 QLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIK 85
++ + +ND + L+D I + + + ++ +KL +L D++
Sbjct: 278 EISELRQQNDELTTLADEAQSLKDE--IDVLRHSSDKVSKLEGQVESYKKKLE-DLGDLR 334
Query: 86 EQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
Q LE K + T + + + + + + T +++ L + L +SKK ++L
Sbjct: 335 RQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDF 394
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE--KLVNESENKIGPK---- 199
E L + E D L E D LK+ E L +C+ + +L + +G +
Sbjct: 395 EYKRLKEKVDSLQKEKDRLRTERDSLKETIEEL--RCVQAQEGQLTTQGLMPLGSQESSD 452
Query: 200 NICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKEL 259
++ A+ E + + + ++N + KLN+ SD+ KI LQS LD EL
Sbjct: 453 SLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDN------EKIALLQSLLDDANLRKNEL 506
Query: 260 CEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESK 319
E + N L + +L + L + +V + +++ +L L E NNE +
Sbjct: 507 -ETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHE--ANNELQ 563
Query: 320 KSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNE 379
K K +++ L+ F +SL + E + + K + ++ ++ E+Y K L +
Sbjct: 564 K--------KRAIIEDLEPRFNNSSLKIEE--LQEALRKKEEEMKQMEERYKKY---LEK 610
Query: 380 CTSELKSVNEK--------LASLNSQLIEKENACNILRIQKER 414
S +++++ K + +L +QL E++ + L + E+
Sbjct: 611 AKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEK 653
Score = 58.8 bits (136), Expect = 1e-07
Identities = 95/510 (18%), Positives = 208/510 (40%), Gaps = 27/510 (5%)
Query: 519 EEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKD 578
E + V + +EL N+A ++L + L + + L A++ EE E D
Sbjct: 144 ESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELD 203
Query: 579 NKLTELVSTINGLKEENNSL-KSLNDVITREKETQAS-----ELERSCQVIKQNGFELDK 632
++ L + L EN L + LN + E + +L+ + +++ F L+
Sbjct: 204 MQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEA 263
Query: 633 MKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCE---EKTRDCSRLEINIKTH 689
K D + DE +L ++ +LK++ + + S+LE ++++
Sbjct: 264 AKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESY 323
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAV 749
+K E + R K ++E + ++++ L E K A + + + + + +
Sbjct: 324 KKKLEDLGD-LRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRL 382
Query: 750 NQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLG 809
++ + + D ++ L+ + + Q G G
Sbjct: 383 SEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQ-G 441
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
P S + S S+ ++ +++E+L+ Q E LK + D+E + L +
Sbjct: 442 LMPL--GSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDD- 498
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMS- 928
A L+K +L E ++ N + + Q VE K + ED L + + +
Sbjct: 499 ---ANLRKNELETENRLVN-QRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
Query: 929 -YDA--EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAK-RKELEDC 984
++A E++K + +++ +E R+ LK + ++Q+A+ K ++ K+ E + +K LE
Sbjct: 555 LHEANNELQKKRAIIEDLEP-RFNNSSLK--IEELQEALRKKEEEMKQMEERYKKYLEKA 611
Query: 985 KAELEELKQRYKE-LDEECETCAEYLKQRE 1013
K+ + L + + E + L++R+
Sbjct: 612 KSVIRTLDPKQNQGAAPEIQALKNQLQERD 641
Score = 57.6 bits (133), Expect = 2e-07
Identities = 101/503 (20%), Positives = 201/503 (39%), Gaps = 43/503 (8%)
Query: 571 MLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFEL 630
M ++ E +K + + + + + + LK + + E + E+ + C + L
Sbjct: 151 MTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELN-EALSAKEEIAQRCHELDMQVAAL 209
Query: 631 DKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHE 690
+ K+ +L D ++L L+ Q E+ + RLE +
Sbjct: 210 QEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYR 269
Query: 691 KTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
E L+K+I E ++ +L L ++ ++LK + D + +
Sbjct: 270 IRCE-------ELEKEISE----LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEG 318
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
Q+ + K +E + +L ++ + R + E
Sbjct: 319 QVESYKKKLED-LGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVE 377
Query: 811 -NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERD 869
+L + K++ + D E +LKE++ S Q+E D L+ L + E +Q ++
Sbjct: 378 LQNRLSEESKKADKL--DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEEL-RCVQAQE 434
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD----VAVNTD----EDWANLHS 921
Q L ++ +L +I T + E+ + + +N + E A L S
Sbjct: 435 GQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQS 494
Query: 922 VVVDRMSYDAEVEK-----NKRLMKT---IEELRYKKQD----LKNTVT---KMQKAMEK 966
++ D E+E N+RL++ +EEL+ QD +++V K+++ +EK
Sbjct: 495 LLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
Query: 967 YTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR-LKEAKIA 1025
+ + E + KR +ED + + +EL E E +KQ EE+ K+ L++AK
Sbjct: 555 LHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSV 614
Query: 1026 LEIVDKLSNQKVALEKQIESLSN 1048
+ +D NQ A E I++L N
Sbjct: 615 IRTLDPKQNQGAAPE--IQALKN 635
Score = 44.8 bits (101), Expect = 0.002
Identities = 51/244 (20%), Positives = 110/244 (45%), Gaps = 12/244 (4%)
Query: 865 LQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANL-HSV 922
L++ E+ RL+ K + L+++I +Q + AD A + ++ L HS
Sbjct: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSS 310
Query: 923 VVDRMS-YDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
D++S + +VE K+ ++ + +LR + + L+ T + ++ ++ A R +L
Sbjct: 311 --DKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQL 368
Query: 982 EDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEK 1041
E K ++ EL+ R E ++ + K+ +E+ L++ K D+L ++ +L++
Sbjct: 369 ETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEK------DRLRTERDSLKE 422
Query: 1042 QIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANR 1101
IE L + G + +Q+ +D + ++ KLI + + N+
Sbjct: 423 TIEELRCVQAQEGQL-TTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQ 481
Query: 1102 ENED 1105
E D
Sbjct: 482 EGSD 485
Score = 40.7 bits (91), Expect = 0.028
Identities = 96/477 (20%), Positives = 192/477 (40%), Gaps = 41/477 (8%)
Query: 61 QSLKESSNEINLKL---EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEM 117
+ LK+++ E+N L E+++ ++ Q +AL+ + +L+ E Q ++Q S+E
Sbjct: 176 RQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIED 235
Query: 118 ENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNEC 177
N + L L+ +LQEE L + + L KE+ +L++ N+
Sbjct: 236 PNSPAGRRHLQLQTQLE-------QLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDE 288
Query: 178 LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSI---SDSN 234
LT + + L +E + ++ + E ++S ++ L L R + + N
Sbjct: 289 LTTLADEAQSLKDEIDVL---RHSSDKVSKLEGQVESYKKKLED-LGDLRRQVKLLEEKN 344
Query: 235 TSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETK 294
T N + +L+ EL + ++ LE ++ ++L +L E ++ K
Sbjct: 345 TMYMQNTV-SLEEEL-----------RKANAARSQLETYK-RQVVELQNRLSEESKKADK 391
Query: 295 AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN 354
+K ++SL ++ + + +D + + L V E T+ + +
Sbjct: 392 LDFEYKRLKEKVDSLQKE--KDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQE 449
Query: 355 IINKY--QIDLDEILEKYTKVQGDLNEC-TSELKSVNEKLASLNSQLIEKENACNIL--- 408
+ +I EI EK ++Q + ++ S NEK+A L S L + N L
Sbjct: 450 SSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETE 509
Query: 409 -RIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITI 467
R+ +R+ E+ S V ++ K + L KL+ + + + + KK I
Sbjct: 510 NRLVNQRLLEVQSQVE-ELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAI 568
Query: 468 LFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNE 524
+ D L ++ S E +E LR + K + TL+ N+
Sbjct: 569 IED-LEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ 624
Score = 35.9 bits (79), Expect = 0.80
Identities = 72/360 (20%), Positives = 147/360 (40%), Gaps = 18/360 (5%)
Query: 702 RLQKQIQEDDKLFIEKET---KLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDL 758
+L+K +E ++ KE + +EL + AL+ + + + + + E +NQ + +D
Sbjct: 177 QLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDP 236
Query: 759 ---VEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD 815
R +L++ + Q T +N +L
Sbjct: 237 NSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEA 296
Query: 816 DSPKRSISVI--SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCA 873
S K I V+ S +VS+L+ ++ S +++L+DL + +++ E Y+Q
Sbjct: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
Query: 874 RLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEV 933
L+K + Q + ++ + Q + ++K AD D ++ L VD + + +
Sbjct: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKAD---KLDFEYKRLKE-KVDSLQKEKDR 412
Query: 934 EKNKR--LMKTIEELR-YKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEE 990
+ +R L +TIEELR + Q+ + T + + + E E+ + L+
Sbjct: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
Query: 991 LKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQK-VALEKQIESLSNT 1049
+ K E + L Q L+ K LE ++L NQ+ + ++ Q+E L +
Sbjct: 473 ENKMLKLNQEGSDNEKIALLQSLLDDANLR--KNELETENRLVNQRLLEVQSQVEELQKS 530
>U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein.
Length = 1312
Score = 60.1 bits (139), Expect = 4e-08
Identities = 163/865 (18%), Positives = 340/865 (39%), Gaps = 80/865 (9%)
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT--MDLDEKLG----------- 286
++I + +++L + +E K + +KN L+ E N++ M LD ++
Sbjct: 225 DQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEK 284
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+N+E E K KV LN L +K + +D +++ L L+ E + +
Sbjct: 285 DNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQE 342
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
E+L++ + Q+ D E + ++L+ + + + I+ N
Sbjct: 343 KSELLVEQ--GRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIK--NFHK 398
Query: 407 ILRIQKERIHEISSAVTIDIVKKEN----ELKEILTKECL--KLSKLKIDIPRDLDQDLP 460
++R ++E + ++ + D +KE ++ EI K+ ++ +LK +I +L
Sbjct: 399 LVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELK 458
Query: 461 AHK-KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD-TL 518
K ++ L + EL + + E+E + E + D TL
Sbjct: 459 NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTL 518
Query: 519 EEAHNEVKSLHEELTK------LYKSKVDENNANLNLIKILSEEIDALKIAIAKN---EE 569
+ E++ L+ T L K K D++ + S+E+ +L E+
Sbjct: 519 RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 578
Query: 570 KMLSLSEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ S S++ N+ + ++ +N L + +N+ + R++E +S ++ V F
Sbjct: 579 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 638
Query: 629 E--LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI 686
E LD++K +I L ++N + C+ + + L+ I
Sbjct: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIE--------------KETKLNELTNKYEALK 732
+ + + + ++++ +K E KE ++ EL NK + +
Sbjct: 699 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 758
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
RD D+E + + +++ ++ + I +
Sbjct: 759 RDIQRLKNDIEEQETLLGTIMPEEE--SAKVCLTDVTIMERFQMELKDVERKIAQQAAKL 816
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQE-LDDLKERY 851
T N++ E D+ I +L +L+ QQE + LK
Sbjct: 817 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKI---------ELNRKLIQDQQEQIQHLKSTT 867
Query: 852 KELDDECETCAEYLQER---DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFAD 907
EL E + LQ R +EQ L E SL +++ + KEQ+ P+E KF
Sbjct: 868 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQV---SPLETTLEKFQQ 924
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEE-LRYKKQDL-KNTVTKMQKAM 964
+ + D+++ E KN MK IE ++ K D K T++ K +
Sbjct: 925 EKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVI 984
Query: 965 EKYTKKDKEFEAKRKELEDCKAEL--EELKQRYKELDEECETCAEYLKQREEQCKR-LKE 1021
+ ++ +K E +++ + ++ +++++R+ + + E LK+ EE+ K+ LKE
Sbjct: 985 AQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE 1044
Query: 1022 AKIALEIVDKLSNQKVALEKQIESL 1046
+ K +QK LE+ I+++
Sbjct: 1045 MGQMQVLQMKSEHQK--LEENIDNI 1067
Score = 52.8 bits (121), Expect = 7e-06
Identities = 81/472 (17%), Positives = 191/472 (40%), Gaps = 39/472 (8%)
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
E+ SK + ++ ++K E+D LK + + E + + + DN++ L S
Sbjct: 222 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 281
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
++++N+ L+ + + + + Q ++L + Q + E ++ D
Sbjct: 282 MEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ---RTVREKERKLVDC------------- 325
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
E + L +++ L ++ E + RL++ H++ ++ +I L Q++ D
Sbjct: 326 ----HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELD 381
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL-ESD 769
F ++ N ++ ++ + K ++ + +N ++ L + +I E+ +
Sbjct: 382 G--FERGPFSERQIKNFHKLVRERQEGEAK---TANQLMNDFAEKETLKQKQIDEIRDKK 436
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ + G +R L + +L + + +S
Sbjct: 437 TGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSN 496
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
V LK ++S Q E DL ++LD E E + R Q L K+K ++Q+ +
Sbjct: 497 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR-TQMEMLTKDKADKDEQIRKI 555
Query: 890 KEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + + + F + EDW + S +++ + D + NK L +
Sbjct: 556 KSR-HSDELTSLLGYFPN--KKQLEDWLHSKSKEINQ-TRDRLAKLNKELASS----EQN 607
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
K + N + + ++ + Y +DK F+ +D +++L+ LK+ ++ ++
Sbjct: 608 KNHINNELKRKEEQLSSY--EDKLFDVCGS--QDFESDLDRLKEEIEKSSKQ 655
Score = 52.4 bits (120), Expect = 9e-06
Identities = 141/721 (19%), Positives = 303/721 (42%), Gaps = 78/721 (10%)
Query: 101 ETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTE 160
E +T + LM+ E E L K K+I + D KT +I EL+ E ++ + E
Sbjct: 407 EAKTANQLMNDFA--EKETL-KQKQIDEIRDK-KTGLGRIIELKSE------ILSKKQNE 456
Query: 161 SDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQC-KLKENLIQSLHIGY 219
N+ E+ L+ +++ + + +D E + E E KN + K++ +Q+
Sbjct: 457 LKNVKYELQQLEGSSDRILE--LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 514
Query: 220 DNTLSKLNRSISDSN--TSTRYNKICTLQSELDAGREDCK---ELCEDFTSIKNHLELHE 274
D TL KL++ + N T+TR + + D + K ++ TS+ + ++
Sbjct: 515 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFP-NK 573
Query: 275 PNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
+ L K E N+ + K+ E+ + + + INNE K+ ++ + Y+D L
Sbjct: 574 KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNH--INNELKRKEEQLSSYEDKLFD 631
Query: 335 VLDAEFGTTSLDVFEILMDN-------------IINKYQIDL-DE------ILEKYTKVQ 374
V ++ + LD + ++ + +++ L DE + ++ + +
Sbjct: 632 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE 691
Query: 375 GDLNECTSELKS----VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+L E S+L+S +KL S S+L +KE R + + + ++ ID+ +KE
Sbjct: 692 AELQEVISDLQSKLRLAPDKLKSTESELKKKEKR----RDEMLGLVPMRQSI-IDLKEKE 746
Query: 431 -NELKEILTKECLKLSKLKIDIPRD---LDQDLPAHKKITI-LFDALITQYELSRTDYEI 485
EL+ L + +LK DI L +P + + L D I + R E+
Sbjct: 747 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTI----MERFQMEL 802
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ + ++ AK +E +++ ++ ++ +L + + +
Sbjct: 803 KDVERKIAQQAAKLQGIDLDRTVQQVN---QEKQEKQHKLDTVSSKI-ELNRKLIQDQQE 858
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS---TINGLKEENNSLKSL 601
+ +K + E+ + K+ I+ N ++ L E+ +L TE+ S I KE+ + L++
Sbjct: 859 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETT 918
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ +EKE ++ S ++ + +L+ +K + D+ K
Sbjct: 919 LEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
Query: 662 LEQNL----ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI---MRLQKQIQEDDKLF 714
E L A +CE+ + ++ T +IQ R + + L+K+ +E ++
Sbjct: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 1035
Query: 715 IEKETKLNELTN-KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E++ L E+ + +K ++ +++++ + N ++ E I + ++R
Sbjct: 1036 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
Query: 774 Q 774
Q
Sbjct: 1096 Q 1096
Score = 43.6 bits (98), Expect = 0.004
Identities = 115/629 (18%), Positives = 269/629 (42%), Gaps = 52/629 (8%)
Query: 26 QLDGAKSK----NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL 81
QL+G+ + + +I+ + K + + + SL+ +++ L KL E+
Sbjct: 466 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 525
Query: 82 FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK----DKEIKNLTDSLKTKS 137
+ + + + L + +D + +IKS + LT K L D L +KS
Sbjct: 526 EQLNHHTTT-RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKS 584
Query: 138 KKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIG 197
K+IN+ + D L+ L E + N N ++LK+ E L+ L + + +
Sbjct: 585 KEINQTR---DRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESD 641
Query: 198 PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS--TRYNKICTLQSELDAGRED 255
+ + + K + +++ G S+ ++D N S ++ ++EL D
Sbjct: 642 LDRLKEEIE-KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISD 700
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN 315
+ E DE LG ++ EI N L Q +N
Sbjct: 701 LQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL--QNVN 758
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE----ILEKYT 371
+ ++ K+ I+ +++LL + E + + + ++ I+ ++Q++L + I ++
Sbjct: 759 RDIQRLKNDIEE-QETLLGTIMPEEESAKVCLTDV---TIMERFQMELKDVERKIAQQAA 814
Query: 372 KVQG-DLNECTSEL-KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
K+QG DL+ ++ + EK L++ + E +++ Q+E+I + S T ++ +
Sbjct: 815 KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS-TTNELKSE 873
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
+ ++ L + +L + +++ ++ Q L +++I + ++ E + ++ EKE+
Sbjct: 874 KLQISTNLQRR-QQLEEQTVELSTEV-QSL--YREIKDAKEQ-VSPLETTLEKFQQEKEE 928
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXF--------DTLEEAHNEVKSLHE-ELTKLYK--S 538
L + T+ + + +++ ++ K E EL K+ S
Sbjct: 929 LINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 988
Query: 539 KVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNS 597
+ +++ +N ++++ ++ID KI ++ L+L +++ +L E+ +E
Sbjct: 989 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN-LTLRKRNEELKEVE------EERKQH 1041
Query: 598 LKSLNDVITREKETQASELERSCQVIKQN 626
LK + + + +++ +LE + IK+N
Sbjct: 1042 LKEMGQMQVLQMKSEHQKLEENIDNIKRN 1070
Score = 40.3 bits (90), Expect = 0.037
Identities = 49/266 (18%), Positives = 119/266 (44%), Gaps = 21/266 (7%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+++++ KE + S + ELD LK R KE++ + + D + L K +E+
Sbjct: 231 EAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSK----IMKLDNEIKALDSRKKQMEKDN 286
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
S L+E+ +E+ + D +N D + H V R V+ ++ L K +E
Sbjct: 287 SELEEK------MEKVFQGTDEQLN---DLYHNHQRTV-REKERKLVDCHRELEKLNKES 336
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETC 1005
R Q+ + + + + + + A+ ++ +LE + +R + + +
Sbjct: 337 RLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNF 396
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
+ +++R+E EAK A ++++ + ++ +KQI+ + + + +
Sbjct: 397 HKLVRERQE-----GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILS 451
Query: 1066 QNQ-QITDVMKENQKLKKMNAKLITI 1090
+ Q ++ +V E Q+L+ + +++ +
Sbjct: 452 KKQNELKNVKYELQQLEGSSDRILEL 477
Score = 35.5 bits (78), Expect = 1.1
Identities = 78/394 (19%), Positives = 157/394 (39%), Gaps = 35/394 (8%)
Query: 66 SSNEINLKL-EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S E+N KL + ++ +K + L+ + + Q R L Q L E + +
Sbjct: 844 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR 903
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSN-LIMENVTESDNLN------KEVDDLKKNNEC 177
EIK+ + + + + Q+E + L N N D LN K + K+ E
Sbjct: 904 EIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 963
Query: 178 LTQKCIDLEKLVNESE-NK-IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT 235
Q D K E+E NK I + C + K K N L +T R + D+ T
Sbjct: 964 YIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLT 1023
Query: 236 STRYNKICTLQSELDAGREDCKELCE-DFTSIKN-HLELHE--PNMTMDLDEKLGENNEF 291
+ N+ L+ + ++ KE+ + +K+ H +L E N+ + + LG +
Sbjct: 1024 LRKRNE--ELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGY 1081
Query: 292 ETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL 351
E + + E++ + +D ++Y++ ++ + E LD++
Sbjct: 1082 EEEIIHFKKELR--------------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKT 1127
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
+D I K+ +E+ K+ DL T + + + + S E +A + R
Sbjct: 1128 LDQAIMKFH---SMKMEEINKIIRDLWRSTYRGQDI--EYIEIRSDADENVSASDKRRNY 1182
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLS 445
R+ + +D+ + + +++L ++L+
Sbjct: 1183 NYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLA 1216
>BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 1898
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 486 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 542
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 543 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 598
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 599 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 654
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 655 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 714
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 715 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 772
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 773 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 832
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 833 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 892
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 234 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 293
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 294 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 350
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 351 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 410
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 411 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 470
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 471 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 530
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 531 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 590
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 591 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 650
Query: 1040 E 1040
+
Sbjct: 651 Q 651
Score = 50.8 bits (116), Expect = 3e-05
Identities = 64/337 (18%), Positives = 144/337 (42%), Gaps = 19/337 (5%)
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E T+ + L + ++ + D+A ++AV + + V+GR++ +++++ ++
Sbjct: 1408 ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1467
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ E R K+ + D +LKE
Sbjct: 1468 SVRRSERERRATLDQVATLERSLQATESELR--ASQEKISKMKANETKLEGDKR--RLKE 1523
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + + L+ + + L+ E + L +R+ Q L+ SL++QV++ + + T
Sbjct: 1524 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1583
Query: 896 -QQPVER-QAKFADVAVN----TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
Q VER A V + D+ ++ S ++ +KN L K + +
Sbjct: 1584 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1643
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
+Q L+ ++ A + ++ K+ + ++++ + E+ +L+ + E + + + E L
Sbjct: 1644 RQVLQE---RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1700
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+QR+E EA AL V KL +++ L++++ SL
Sbjct: 1701 RQRQE-----GEA-AALNTVQKLQDERRLLQERLGSL 1731
Score = 43.6 bits (98), Expect = 0.004
Identities = 140/794 (17%), Positives = 312/794 (39%), Gaps = 62/794 (7%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDL 281
L L + +SDS + R L+ +L R+ + + ++ L N +
Sbjct: 430 LGTLRKQLSDSESERR-----ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 484
Query: 282 DEK-LGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEF 340
++ L + + + + + + + L + E+L + ++ D +D + E
Sbjct: 485 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 544
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
L+ E +++ K +++ E L + T +Q D+ + +E V E L + +E
Sbjct: 545 SHRQLEQLEGKR-SVLAKELVEVREALSRAT-LQRDMLQ--AEKAEVAEALTKAEAGRVE 600
Query: 401 KENACNILRIQKERIHE-IS--SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E + LR ++ + + +S SA+ + + + +L ++ + + S L+ R +Q
Sbjct: 601 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ-GRQRQAEQ 659
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ ++ + L + E++R E LR+ +A+ +
Sbjct: 660 EATVAREEQERLEELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQ 716
Query: 518 LEEAHNEVKSLHEELTKLYKS---KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L + ++ +EL + + +V+ + L++E L + + E + +L
Sbjct: 717 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 776
Query: 575 SEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE+ +L + G L E L L + + E + L + + + EL +
Sbjct: 777 SEEATRLRLEKEALEGSLFEVQRQLAQL-EARREQLEAEGQALLLAKETLTG---ELAGL 832
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
+ I+ +A+ E +L+EQ D RL+ + +
Sbjct: 833 RQQIIATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQRLQREKEAAWREL 890
Query: 694 EIQNRMIMRLQKQIQ-EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E + +LQ Q+Q E ++L E + EL+ + AL+++ D + ES ++ Q
Sbjct: 891 EAERA---QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQ---QA 944
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ K+ + ++E R AT+ + RD
Sbjct: 945 LSLKESEKTALSEKLMGTR-HSLATISLEMER-------------------QKRDAQSRQ 984
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ D S +++ +Q +E + QE+ L+E+ ++L + ++C +E Q
Sbjct: 985 EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL 1044
Query: 873 ARLKKEKLSLEQQVSNLKEQIR-TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+ + L +++ + ++R +Q+ E Q + A + + A + R S +
Sbjct: 1045 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL--RRSNEE 1102
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE----DCKAE 987
K+ L+ +D + + +++A K+ E +E+E + + E
Sbjct: 1103 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1162
Query: 988 LEELKQRYKELDEE 1001
L+EL+++ K LD E
Sbjct: 1163 LQELRRQMKMLDSE 1176
Score = 42.7 bits (96), Expect = 0.007
Identities = 74/396 (18%), Positives = 155/396 (39%), Gaps = 25/396 (6%)
Query: 660 SLLEQNLALKEQCEEKTRD-CSRLEINIKTHEKTAEIQNRMI--MRLQKQIQEDDKLFIE 716
+L E+++ E+ T D + LE +++ E I M+ + E DK ++
Sbjct: 1463 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1522
Query: 717 KETKLNEL-TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
+ +E T K E +R + +L+ SR ++ Q ++ R+ L+ + +
Sbjct: 1523 EVLDASESRTVKLELQRRSLEG---ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1579
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
D+ R L E L S S++ D + L++
Sbjct: 1580 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE--ALAQS-SASLNSTRDKNL-HLQK 1635
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L +C+ + L+ER + EQ L+ E LE Q + Q++
Sbjct: 1636 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1695
Query: 896 QQPVERQAKFAD-VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLK 954
+ V RQ + + A+NT + + ++ +R+ L + + +L +K++++
Sbjct: 1696 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLG---------SLQRALAQLEAEKREVE 1746
Query: 955 NTVTKMQKAMEKYTKK-DKEFEAKRKELED---CKAELEELKQRYKELDEECETCAEYLK 1010
+ +++K + DK K + ED AE L + + E ++
Sbjct: 1747 RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1806
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q E Q L+++ ++ Q++ L++++E L
Sbjct: 1807 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERL 1842
Score = 39.9 bits (89), Expect = 0.049
Identities = 96/481 (19%), Positives = 205/481 (42%), Gaps = 55/481 (11%)
Query: 159 TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-----KNICAQCKLKENLIQ 213
T++ LN+++ +++ + T + L+K V ESE + A+ L+E ++
Sbjct: 1411 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVR 1470
Query: 214 SLHIGYDNTLSK---LNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTS 265
TL + L RS+ + + R +K+ +++L+ + KE+ + S
Sbjct: 1471 RSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES 1530
Query: 266 IKNHLELHEPNMTMDLD-EKLG-ENNEFETKAVK----------VMSEIKRNLNSLSEQL 313
LEL ++ +L +LG + E + +A++ SE+K L+ +
Sbjct: 1531 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1590
Query: 314 INNESKKSKDHIDRYKDSLLAVLDA-EFGTTSLDVF---EILMDNIINKYQIDLDEILEK 369
+N K ++ +D + + +A + SL+ + + + + D + E+
Sbjct: 1591 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1650
Query: 370 YTKVQGDLNECTSELKSVNE-------KLASLNSQLIEKENACNILRIQKERIHEISSAV 422
+ L+E + S+ E ++A L Q +E E LR + R + A
Sbjct: 1651 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQEGEAA 1709
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
++ V+K + + +L + +L L+ + + L+ + ++ + + + L RT
Sbjct: 1710 ALNTVQKLQDERRLLQE---RLGSLQRALAQ-LEAEKREVERSALRLEK--DRVALRRTL 1763
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD- 541
++E+EKLR T + + L EA +++ L ++ L +S
Sbjct: 1764 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE-LAEAQRQIQQLEAQVVVLEQSHSPA 1822
Query: 542 --ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-----LTELVSTING-LKE 593
E +A ++ L +E++ L+ A A+ E+ L E+ ++ L E VST+ G L++
Sbjct: 1823 QLEVDAQQQQLE-LQQEVERLRSAQAQT-ERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1880
Query: 594 E 594
E
Sbjct: 1881 E 1881
Score = 39.9 bits (89), Expect = 0.049
Identities = 78/405 (19%), Positives = 165/405 (40%), Gaps = 31/405 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ + +E+ EK+S +K ++ LEG + L + D S+ LE++
Sbjct: 1488 RSLQATESELRASQEKIS----KMKANETKLEGDKRRL---KEVLDASESRTVKLELQRR 1540
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ + E++ L + + LQ+ D+L + ++ ++ L V+ L N L +
Sbjct: 1541 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERL---NGALAK 1597
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
V ESE + K L E L QS ++T K N + + T+ ++
Sbjct: 1598 --------VEESEGALRDK----VRGLTEALAQS-SASLNSTRDK-NLHLQKALTACEHD 1643
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ LQ LDA R+ E + +S+ ++ L ++L E + + V
Sbjct: 1644 R-QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1702
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+ + Q + +E + ++ + + + LA L+AE + D +
Sbjct: 1703 RQEGEAAALNTVQKLQDERRLLQERLGSLQRA-LAQLEAEKREVERSALRLEKDRV--AL 1759
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
+ LD++ + + D ++E ++ L +L E + L Q + +
Sbjct: 1760 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH 1819
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
S +++ ++ +L+ L +E +L + R L+ AH++
Sbjct: 1820 SPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTLEARERAHRQ 1862
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 502 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 558
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 559 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 616
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 617 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 672
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 673 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 730
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 731 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 790
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 791 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 850
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 851 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 910
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 911 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 961
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 962 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 1006
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 1007 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1063
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1064 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1123
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1124 KEQKLALLEEARTAV 1138
>BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 2017
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 662 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 773
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 774 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 833
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 834 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 891
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 353 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 412
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 413 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 469
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 470 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 589
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 590 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 769
Query: 1040 E 1040
+
Sbjct: 770 Q 770
Score = 50.8 bits (116), Expect = 3e-05
Identities = 64/337 (18%), Positives = 144/337 (42%), Gaps = 19/337 (5%)
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E T+ + L + ++ + D+A ++AV + + V+GR++ +++++ ++
Sbjct: 1527 ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1586
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ E R K+ + D +LKE
Sbjct: 1587 SVRRSERERRATLDQVATLERSLQATESELR--ASQEKISKMKANETKLEGDKR--RLKE 1642
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + + L+ + + L+ E + L +R+ Q L+ SL++QV++ + + T
Sbjct: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
Query: 896 -QQPVER-QAKFADVAVN----TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
Q VER A V + D+ ++ S ++ +KN L K + +
Sbjct: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
+Q L+ ++ A + ++ K+ + ++++ + E+ +L+ + E + + + E L
Sbjct: 1763 RQVLQE---RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1819
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+QR+E EA AL V KL +++ L++++ SL
Sbjct: 1820 RQRQE-----GEA-AALNTVQKLQDERRLLQERLGSL 1850
Score = 43.6 bits (98), Expect = 0.004
Identities = 140/794 (17%), Positives = 312/794 (39%), Gaps = 62/794 (7%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDL 281
L L + +SDS + R L+ +L R+ + + ++ L N +
Sbjct: 549 LGTLRKQLSDSESERR-----ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 603
Query: 282 DEK-LGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEF 340
++ L + + + + + + + L + E+L + ++ D +D + E
Sbjct: 604 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
L+ E +++ K +++ E L + T +Q D+ + +E V E L + +E
Sbjct: 664 SHRQLEQLEGKR-SVLAKELVEVREALSRAT-LQRDMLQ--AEKAEVAEALTKAEAGRVE 719
Query: 401 KENACNILRIQKERIHE-IS--SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E + LR ++ + + +S SA+ + + + +L ++ + + S L+ R +Q
Sbjct: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ-GRQRQAEQ 778
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ ++ + L + E++R E LR+ +A+ +
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQ 835
Query: 518 LEEAHNEVKSLHEELTKLYKS---KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L + ++ +EL + + +V+ + L++E L + + E + +L
Sbjct: 836 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895
Query: 575 SEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE+ +L + G L E L L + + E + L + + + EL +
Sbjct: 896 SEEATRLRLEKEALEGSLFEVQRQLAQL-EARREQLEAEGQALLLAKETLTG---ELAGL 951
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
+ I+ +A+ E +L+EQ D RL+ + +
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 694 EIQNRMIMRLQKQIQ-EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E + +LQ Q+Q E ++L E + EL+ + AL+++ D + ES ++ Q
Sbjct: 1010 EAERA---QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQ---QA 1063
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ K+ + ++E R AT+ + RD
Sbjct: 1064 LSLKESEKTALSEKLMGTR-HSLATISLEMER-------------------QKRDAQSRQ 1103
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ D S +++ +Q +E + QE+ L+E+ ++L + ++C +E Q
Sbjct: 1104 EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL 1163
Query: 873 ARLKKEKLSLEQQVSNLKEQIR-TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+ + L +++ + ++R +Q+ E Q + A + + A + R S +
Sbjct: 1164 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL--RRSNEE 1221
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE----DCKAE 987
K+ L+ +D + + +++A K+ E +E+E + + E
Sbjct: 1222 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1281
Query: 988 LEELKQRYKELDEE 1001
L+EL+++ K LD E
Sbjct: 1282 LQELRRQMKMLDSE 1295
Score = 42.7 bits (96), Expect = 0.007
Identities = 74/396 (18%), Positives = 155/396 (39%), Gaps = 25/396 (6%)
Query: 660 SLLEQNLALKEQCEEKTRD-CSRLEINIKTHEKTAEIQNRMI--MRLQKQIQEDDKLFIE 716
+L E+++ E+ T D + LE +++ E I M+ + E DK ++
Sbjct: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641
Query: 717 KETKLNEL-TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
+ +E T K E +R + +L+ SR ++ Q ++ R+ L+ + +
Sbjct: 1642 EVLDASESRTVKLELQRRSLEG---ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1698
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
D+ R L E L S S++ D + L++
Sbjct: 1699 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE--ALAQS-SASLNSTRDKNL-HLQK 1754
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L +C+ + L+ER + EQ L+ E LE Q + Q++
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814
Query: 896 QQPVERQAKFAD-VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLK 954
+ V RQ + + A+NT + + ++ +R+ L + + +L +K++++
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLG---------SLQRALAQLEAEKREVE 1865
Query: 955 NTVTKMQKAMEKYTKK-DKEFEAKRKELED---CKAELEELKQRYKELDEECETCAEYLK 1010
+ +++K + DK K + ED AE L + + E ++
Sbjct: 1866 RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q E Q L+++ ++ Q++ L++++E L
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERL 1961
Score = 39.9 bits (89), Expect = 0.049
Identities = 96/481 (19%), Positives = 205/481 (42%), Gaps = 55/481 (11%)
Query: 159 TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-----KNICAQCKLKENLIQ 213
T++ LN+++ +++ + T + L+K V ESE + A+ L+E ++
Sbjct: 1530 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVR 1589
Query: 214 SLHIGYDNTLSK---LNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTS 265
TL + L RS+ + + R +K+ +++L+ + KE+ + S
Sbjct: 1590 RSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES 1649
Query: 266 IKNHLELHEPNMTMDLD-EKLG-ENNEFETKAVK----------VMSEIKRNLNSLSEQL 313
LEL ++ +L +LG + E + +A++ SE+K L+ +
Sbjct: 1650 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1709
Query: 314 INNESKKSKDHIDRYKDSLLAVLDA-EFGTTSLDVF---EILMDNIINKYQIDLDEILEK 369
+N K ++ +D + + +A + SL+ + + + + D + E+
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1769
Query: 370 YTKVQGDLNECTSELKSVNE-------KLASLNSQLIEKENACNILRIQKERIHEISSAV 422
+ L+E + S+ E ++A L Q +E E LR + R + A
Sbjct: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQEGEAA 1828
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
++ V+K + + +L + +L L+ + + L+ + ++ + + + L RT
Sbjct: 1829 ALNTVQKLQDERRLLQE---RLGSLQRALAQ-LEAEKREVERSALRLEK--DRVALRRTL 1882
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD- 541
++E+EKLR T + + L EA +++ L ++ L +S
Sbjct: 1883 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE-LAEAQRQIQQLEAQVVVLEQSHSPA 1941
Query: 542 --ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-----LTELVSTING-LKE 593
E +A ++ L +E++ L+ A A+ E+ L E+ ++ L E VST+ G L++
Sbjct: 1942 QLEVDAQQQQLE-LQQEVERLRSAQAQT-ERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
Query: 594 E 594
E
Sbjct: 2000 E 2000
Score = 39.9 bits (89), Expect = 0.049
Identities = 78/405 (19%), Positives = 165/405 (40%), Gaps = 31/405 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ + +E+ EK+S +K ++ LEG + L + D S+ LE++
Sbjct: 1607 RSLQATESELRASQEKIS----KMKANETKLEGDKRRL---KEVLDASESRTVKLELQRR 1659
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ + E++ L + + LQ+ D+L + ++ ++ L V+ L N L +
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERL---NGALAK 1716
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
V ESE + K L E L QS ++T K N + + T+ ++
Sbjct: 1717 --------VEESEGALRDK----VRGLTEALAQS-SASLNSTRDK-NLHLQKALTACEHD 1762
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ LQ LDA R+ E + +S+ ++ L ++L E + + V
Sbjct: 1763 R-QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+ + Q + +E + ++ + + + LA L+AE + D +
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRA-LAQLEAEKREVERSALRLEKDRV--AL 1878
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
+ LD++ + + D ++E ++ L +L E + L Q + +
Sbjct: 1879 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH 1938
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
S +++ ++ +L+ L +E +L + R L+ AH++
Sbjct: 1939 SPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTLEARERAHRQ 1981
Score = 38.7 bits (86), Expect = 0.11
Identities = 45/209 (21%), Positives = 87/209 (41%), Gaps = 13/209 (6%)
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
LLS Q+E L++ ++D A+ ERDE + LEQ + ++ TQ
Sbjct: 76 LLSLQEENQLLQQELSRVED---LLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ 132
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+P + ++ E+ A+ R A E +R + ++ L+ K K
Sbjct: 133 EPRGLVRQSVELRRQLQEEQASY------RRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
++++ ++ ++ E E +R + +LE R +E + + A+ EQ
Sbjct: 187 CSELE---QQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243
Query: 1017 KRLKEAKIAL-EIVDKLSNQKVALEKQIE 1044
+ A AL E + K++N K++E
Sbjct: 244 DQAGSANQALSEDIRKVTNDWTRCRKELE 272
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 621 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 677
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 735
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 736 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 791
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 970 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 1029
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 1030 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 1081 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 1125
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 1126 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1243 KEQKLALLEEARTAV 1257
Score = 33.9 bits (74), Expect = 3.2
Identities = 32/144 (22%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 605 ITREKETQASELERSCQVIKQNGFELDKM--KADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ E + EL R ++ Q+ E D++ K + + E + L+
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
Query: 663 EQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
Q++ L+ Q +E+ R ++ +++ + Q +++ RLQ +I + K E E +L
Sbjct: 139 RQSVELRRQLQEEQASYRR---KLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL 195
Query: 723 ELTNKYEALK-RDYDAAVKDLESS 745
E + + E + RD + + +DLES+
Sbjct: 196 ERSGELEQQRLRDTEHS-QDLESA 218
>BC126912-1|AAI26913.1| 1132|Homo sapiens CROCC protein protein.
Length = 1132
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 468 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 524
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 525 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 580
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 581 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 636
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 637 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 696
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 697 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 754
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 755 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 814
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 815 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 874
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 216 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 275
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 276 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 332
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 333 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 392
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 393 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 452
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 453 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 512
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 513 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 572
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 573 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 632
Query: 1040 E 1040
+
Sbjct: 633 Q 633
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 484 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 540
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 541 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 598
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 599 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 654
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 655 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 712
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 713 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 772
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 773 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 832
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 833 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 892
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 893 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 943
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 944 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 988
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 989 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1045
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1046 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1105
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1106 KEQKLALLEEARTAV 1120
>BC126911-1|AAI26912.1| 1132|Homo sapiens CROCC protein protein.
Length = 1132
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 468 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 524
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 525 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 580
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 581 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 636
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 637 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 696
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 697 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 754
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 755 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 814
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 815 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 874
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 216 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 275
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 276 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 332
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 333 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 392
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 393 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 452
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 453 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 512
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 513 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 572
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 573 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 632
Query: 1040 E 1040
+
Sbjct: 633 Q 633
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 484 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 540
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 541 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 598
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 599 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 654
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 655 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 712
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 713 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 772
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 773 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 832
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 833 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 892
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 893 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 943
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 944 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 988
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 989 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1045
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1046 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1105
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1106 KEQKLALLEEARTAV 1120
>AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 1898
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 486 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 542
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 543 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 598
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 599 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 654
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 655 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 714
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 715 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 772
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 773 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 832
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 833 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 892
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 234 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 293
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 294 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 350
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 351 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 410
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 411 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 470
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 471 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 530
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 531 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 590
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 591 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 650
Query: 1040 E 1040
+
Sbjct: 651 Q 651
Score = 50.8 bits (116), Expect = 3e-05
Identities = 64/337 (18%), Positives = 144/337 (42%), Gaps = 19/337 (5%)
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E T+ + L + ++ + D+A ++AV + + V+GR++ +++++ ++
Sbjct: 1408 ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1467
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ E R K+ + D +LKE
Sbjct: 1468 SVRRSERERRATLDQVATLERSLQATESELR--ASQEKISKMKANETKLEGDKR--RLKE 1523
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + + L+ + + L+ E + L +R+ Q L+ SL++QV++ + + T
Sbjct: 1524 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1583
Query: 896 -QQPVER-QAKFADVAVN----TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
Q VER A V + D+ ++ S ++ +KN L K + +
Sbjct: 1584 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1643
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
+Q L+ ++ A + ++ K+ + ++++ + E+ +L+ + E + + + E L
Sbjct: 1644 RQVLQE---RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1700
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+QR+E EA AL V KL +++ L++++ SL
Sbjct: 1701 RQRQE-----GEA-AALNTVQKLQDERRLLQERLGSL 1731
Score = 43.6 bits (98), Expect = 0.004
Identities = 140/794 (17%), Positives = 312/794 (39%), Gaps = 62/794 (7%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDL 281
L L + +SDS + R L+ +L R+ + + ++ L N +
Sbjct: 430 LGTLRKQLSDSESERR-----ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 484
Query: 282 DEK-LGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEF 340
++ L + + + + + + + L + E+L + ++ D +D + E
Sbjct: 485 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 544
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
L+ E +++ K +++ E L + T +Q D+ + +E V E L + +E
Sbjct: 545 SHRQLEQLEGKR-SVLAKELVEVREALSRAT-LQRDMLQ--AEKAEVAEALTKAEAGRVE 600
Query: 401 KENACNILRIQKERIHE-IS--SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E + LR ++ + + +S SA+ + + + +L ++ + + S L+ R +Q
Sbjct: 601 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ-GRQRQAEQ 659
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ ++ + L + E++R E LR+ +A+ +
Sbjct: 660 EATVAREEQERLEELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQ 716
Query: 518 LEEAHNEVKSLHEELTKLYKS---KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L + ++ +EL + + +V+ + L++E L + + E + +L
Sbjct: 717 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 776
Query: 575 SEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE+ +L + G L E L L + + E + L + + + EL +
Sbjct: 777 SEEATRLRLEKEALEGSLFEVQRQLAQL-EARREQLEAEGQALLLAKETLTG---ELAGL 832
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
+ I+ +A+ E +L+EQ D RL+ + +
Sbjct: 833 RQQIIATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQRLQREKEAAWREL 890
Query: 694 EIQNRMIMRLQKQIQ-EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E + +LQ Q+Q E ++L E + EL+ + AL+++ D + ES ++ Q
Sbjct: 891 EAERA---QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQ---QA 944
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ K+ + ++E R AT+ + RD
Sbjct: 945 LSLKESEKTALSEKLMGTR-HSLATISLEMER-------------------QKRDAQSRQ 984
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ D S +++ +Q +E + QE+ L+E+ ++L + ++C +E Q
Sbjct: 985 EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL 1044
Query: 873 ARLKKEKLSLEQQVSNLKEQIR-TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+ + L +++ + ++R +Q+ E Q + A + + A + R S +
Sbjct: 1045 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL--RRSNEE 1102
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE----DCKAE 987
K+ L+ +D + + +++A K+ E +E+E + + E
Sbjct: 1103 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1162
Query: 988 LEELKQRYKELDEE 1001
L+EL+++ K LD E
Sbjct: 1163 LQELRRQMKMLDSE 1176
Score = 42.7 bits (96), Expect = 0.007
Identities = 74/396 (18%), Positives = 155/396 (39%), Gaps = 25/396 (6%)
Query: 660 SLLEQNLALKEQCEEKTRD-CSRLEINIKTHEKTAEIQNRMI--MRLQKQIQEDDKLFIE 716
+L E+++ E+ T D + LE +++ E I M+ + E DK ++
Sbjct: 1463 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1522
Query: 717 KETKLNEL-TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
+ +E T K E +R + +L+ SR ++ Q ++ R+ L+ + +
Sbjct: 1523 EVLDASESRTVKLELQRRSLEG---ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1579
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
D+ R L E L S S++ D + L++
Sbjct: 1580 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE--ALAQS-SASLNSTRDKNL-HLQK 1635
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L +C+ + L+ER + EQ L+ E LE Q + Q++
Sbjct: 1636 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1695
Query: 896 QQPVERQAKFAD-VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLK 954
+ V RQ + + A+NT + + ++ +R+ L + + +L +K++++
Sbjct: 1696 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLG---------SLQRALAQLEAEKREVE 1746
Query: 955 NTVTKMQKAMEKYTKK-DKEFEAKRKELED---CKAELEELKQRYKELDEECETCAEYLK 1010
+ +++K + DK K + ED AE L + + E ++
Sbjct: 1747 RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1806
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q E Q L+++ ++ Q++ L++++E L
Sbjct: 1807 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERL 1842
Score = 39.9 bits (89), Expect = 0.049
Identities = 96/481 (19%), Positives = 205/481 (42%), Gaps = 55/481 (11%)
Query: 159 TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-----KNICAQCKLKENLIQ 213
T++ LN+++ +++ + T + L+K V ESE + A+ L+E ++
Sbjct: 1411 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVR 1470
Query: 214 SLHIGYDNTLSK---LNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTS 265
TL + L RS+ + + R +K+ +++L+ + KE+ + S
Sbjct: 1471 RSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES 1530
Query: 266 IKNHLELHEPNMTMDLD-EKLG-ENNEFETKAVK----------VMSEIKRNLNSLSEQL 313
LEL ++ +L +LG + E + +A++ SE+K L+ +
Sbjct: 1531 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1590
Query: 314 INNESKKSKDHIDRYKDSLLAVLDA-EFGTTSLDVF---EILMDNIINKYQIDLDEILEK 369
+N K ++ +D + + +A + SL+ + + + + D + E+
Sbjct: 1591 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1650
Query: 370 YTKVQGDLNECTSELKSVNE-------KLASLNSQLIEKENACNILRIQKERIHEISSAV 422
+ L+E + S+ E ++A L Q +E E LR + R + A
Sbjct: 1651 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQEGEAA 1709
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
++ V+K + + +L + +L L+ + + L+ + ++ + + + L RT
Sbjct: 1710 ALNTVQKLQDERRLLQE---RLGSLQRALAQ-LEAEKREVERSALRLEK--DRVALRRTL 1763
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD- 541
++E+EKLR T + + L EA +++ L ++ L +S
Sbjct: 1764 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE-LAEAQRQIQQLEAQVVVLEQSHSPA 1822
Query: 542 --ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-----LTELVSTING-LKE 593
E +A ++ L +E++ L+ A A+ E+ L E+ ++ L E VST+ G L++
Sbjct: 1823 QLEVDAQQQQLE-LQQEVERLRSAQAQT-ERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1880
Query: 594 E 594
E
Sbjct: 1881 E 1881
Score = 39.9 bits (89), Expect = 0.049
Identities = 78/405 (19%), Positives = 165/405 (40%), Gaps = 31/405 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ + +E+ EK+S +K ++ LEG + L + D S+ LE++
Sbjct: 1488 RSLQATESELRASQEKIS----KMKANETKLEGDKRRL---KEVLDASESRTVKLELQRR 1540
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ + E++ L + + LQ+ D+L + ++ ++ L V+ L N L +
Sbjct: 1541 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERL---NGALAK 1597
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
V ESE + K L E L QS ++T K N + + T+ ++
Sbjct: 1598 --------VEESEGALRDK----VRGLTEALAQS-SASLNSTRDK-NLHLQKALTACEHD 1643
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ LQ LDA R+ E + +S+ ++ L ++L E + + V
Sbjct: 1644 R-QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1702
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+ + Q + +E + ++ + + + LA L+AE + D +
Sbjct: 1703 RQEGEAAALNTVQKLQDERRLLQERLGSLQRA-LAQLEAEKREVERSALRLEKDRV--AL 1759
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
+ LD++ + + D ++E ++ L +L E + L Q + +
Sbjct: 1760 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH 1819
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
S +++ ++ +L+ L +E +L + R L+ AH++
Sbjct: 1820 SPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTLEARERAHRQ 1862
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 502 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 558
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 559 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 616
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 617 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 672
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 673 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 730
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 731 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 790
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 791 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 850
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 851 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 910
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 911 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 961
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 962 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 1006
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 1007 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1063
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1064 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1123
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1124 KEQKLALLEEARTAV 1138
>AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 2017
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 662 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 773
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 774 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 833
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 834 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 891
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 353 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 412
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 413 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 469
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 470 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 589
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 590 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 769
Query: 1040 E 1040
+
Sbjct: 770 Q 770
Score = 50.8 bits (116), Expect = 3e-05
Identities = 64/337 (18%), Positives = 144/337 (42%), Gaps = 19/337 (5%)
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E T+ + L + ++ + D+A ++AV + + V+GR++ +++++ ++
Sbjct: 1527 ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1586
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ E R K+ + D +LKE
Sbjct: 1587 SVRRSERERRATLDQVATLERSLQATESELR--ASQEKISKMKANETKLEGDKR--RLKE 1642
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + + L+ + + L+ E + L +R+ Q L+ SL++QV++ + + T
Sbjct: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
Query: 896 -QQPVER-QAKFADVAVN----TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
Q VER A V + D+ ++ S ++ +KN L K + +
Sbjct: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
+Q L+ ++ A + ++ K+ + ++++ + E+ +L+ + E + + + E L
Sbjct: 1763 RQVLQE---RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1819
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+QR+E EA AL V KL +++ L++++ SL
Sbjct: 1820 RQRQE-----GEA-AALNTVQKLQDERRLLQERLGSL 1850
Score = 43.6 bits (98), Expect = 0.004
Identities = 140/794 (17%), Positives = 312/794 (39%), Gaps = 62/794 (7%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDL 281
L L + +SDS + R L+ +L R+ + + ++ L N +
Sbjct: 549 LGTLRKQLSDSESERR-----ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 603
Query: 282 DEK-LGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEF 340
++ L + + + + + + + L + E+L + ++ D +D + E
Sbjct: 604 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
L+ E +++ K +++ E L + T +Q D+ + +E V E L + +E
Sbjct: 664 SHRQLEQLEGKR-SVLAKELVEVREALSRAT-LQRDMLQ--AEKAEVAEALTKAEAGRVE 719
Query: 401 KENACNILRIQKERIHE-IS--SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E + LR ++ + + +S SA+ + + + +L ++ + + S L+ R +Q
Sbjct: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ-GRQRQAEQ 778
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ ++ + L + E++R E LR+ +A+ +
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQ 835
Query: 518 LEEAHNEVKSLHEELTKLYKS---KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L + ++ +EL + + +V+ + L++E L + + E + +L
Sbjct: 836 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895
Query: 575 SEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE+ +L + G L E L L + + E + L + + + EL +
Sbjct: 896 SEEATRLRLEKEALEGSLFEVQRQLAQL-EARREQLEAEGQALLLAKETLTG---ELAGL 951
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
+ I+ +A+ E +L+EQ D RL+ + +
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 694 EIQNRMIMRLQKQIQ-EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E + +LQ Q+Q E ++L E + EL+ + AL+++ D + ES ++ Q
Sbjct: 1010 EAERA---QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQ---QA 1063
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ K+ + ++E R AT+ + RD
Sbjct: 1064 LSLKESEKTALSEKLMGTR-HSLATISLEMER-------------------QKRDAQSRQ 1103
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ D S +++ +Q +E + QE+ L+E+ ++L + ++C +E Q
Sbjct: 1104 EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL 1163
Query: 873 ARLKKEKLSLEQQVSNLKEQIR-TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+ + L +++ + ++R +Q+ E Q + A + + A + R S +
Sbjct: 1164 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL--RRSNEE 1221
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE----DCKAE 987
K+ L+ +D + + +++A K+ E +E+E + + E
Sbjct: 1222 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1281
Query: 988 LEELKQRYKELDEE 1001
L+EL+++ K LD E
Sbjct: 1282 LQELRRQMKMLDSE 1295
Score = 42.7 bits (96), Expect = 0.007
Identities = 74/396 (18%), Positives = 155/396 (39%), Gaps = 25/396 (6%)
Query: 660 SLLEQNLALKEQCEEKTRD-CSRLEINIKTHEKTAEIQNRMI--MRLQKQIQEDDKLFIE 716
+L E+++ E+ T D + LE +++ E I M+ + E DK ++
Sbjct: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641
Query: 717 KETKLNEL-TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
+ +E T K E +R + +L+ SR ++ Q ++ R+ L+ + +
Sbjct: 1642 EVLDASESRTVKLELQRRSLEG---ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1698
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
D+ R L E L S S++ D + L++
Sbjct: 1699 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE--ALAQS-SASLNSTRDKNL-HLQK 1754
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L +C+ + L+ER + EQ L+ E LE Q + Q++
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814
Query: 896 QQPVERQAKFAD-VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLK 954
+ V RQ + + A+NT + + ++ +R+ L + + +L +K++++
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLG---------SLQRALAQLEAEKREVE 1865
Query: 955 NTVTKMQKAMEKYTKK-DKEFEAKRKELED---CKAELEELKQRYKELDEECETCAEYLK 1010
+ +++K + DK K + ED AE L + + E ++
Sbjct: 1866 RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q E Q L+++ ++ Q++ L++++E L
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERL 1961
Score = 39.9 bits (89), Expect = 0.049
Identities = 96/481 (19%), Positives = 205/481 (42%), Gaps = 55/481 (11%)
Query: 159 TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-----KNICAQCKLKENLIQ 213
T++ LN+++ +++ + T + L+K V ESE + A+ L+E ++
Sbjct: 1530 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVR 1589
Query: 214 SLHIGYDNTLSK---LNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTS 265
TL + L RS+ + + R +K+ +++L+ + KE+ + S
Sbjct: 1590 RSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES 1649
Query: 266 IKNHLELHEPNMTMDLD-EKLG-ENNEFETKAVK----------VMSEIKRNLNSLSEQL 313
LEL ++ +L +LG + E + +A++ SE+K L+ +
Sbjct: 1650 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1709
Query: 314 INNESKKSKDHIDRYKDSLLAVLDA-EFGTTSLDVF---EILMDNIINKYQIDLDEILEK 369
+N K ++ +D + + +A + SL+ + + + + D + E+
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1769
Query: 370 YTKVQGDLNECTSELKSVNE-------KLASLNSQLIEKENACNILRIQKERIHEISSAV 422
+ L+E + S+ E ++A L Q +E E LR + R + A
Sbjct: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQEGEAA 1828
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
++ V+K + + +L + +L L+ + + L+ + ++ + + + L RT
Sbjct: 1829 ALNTVQKLQDERRLLQE---RLGSLQRALAQ-LEAEKREVERSALRLEK--DRVALRRTL 1882
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD- 541
++E+EKLR T + + L EA +++ L ++ L +S
Sbjct: 1883 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE-LAEAQRQIQQLEAQVVVLEQSHSPA 1941
Query: 542 --ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-----LTELVSTING-LKE 593
E +A ++ L +E++ L+ A A+ E+ L E+ ++ L E VST+ G L++
Sbjct: 1942 QLEVDAQQQQLE-LQQEVERLRSAQAQT-ERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
Query: 594 E 594
E
Sbjct: 2000 E 2000
Score = 39.9 bits (89), Expect = 0.049
Identities = 78/405 (19%), Positives = 165/405 (40%), Gaps = 31/405 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ + +E+ EK+S +K ++ LEG + L + D S+ LE++
Sbjct: 1607 RSLQATESELRASQEKIS----KMKANETKLEGDKRRL---KEVLDASESRTVKLELQRR 1659
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ + E++ L + + LQ+ D+L + ++ ++ L V+ L N L +
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERL---NGALAK 1716
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
V ESE + K L E L QS ++T K N + + T+ ++
Sbjct: 1717 --------VEESEGALRDK----VRGLTEALAQS-SASLNSTRDK-NLHLQKALTACEHD 1762
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ LQ LDA R+ E + +S+ ++ L ++L E + + V
Sbjct: 1763 R-QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+ + Q + +E + ++ + + + LA L+AE + D +
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRA-LAQLEAEKREVERSALRLEKDRV--AL 1878
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
+ LD++ + + D ++E ++ L +L E + L Q + +
Sbjct: 1879 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH 1938
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
S +++ ++ +L+ L +E +L + R L+ AH++
Sbjct: 1939 SPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTLEARERAHRQ 1981
Score = 38.7 bits (86), Expect = 0.11
Identities = 45/209 (21%), Positives = 87/209 (41%), Gaps = 13/209 (6%)
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
LLS Q+E L++ ++D A+ ERDE + LEQ + ++ TQ
Sbjct: 76 LLSLQEENQLLQQELSRVED---LLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ 132
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
+P + ++ E+ A+ R A E +R + ++ L+ K K
Sbjct: 133 EPRGLVRQSVELRRQLQEEQASY------RRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
Query: 957 VTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQC 1016
++++ ++ ++ E E +R + +LE R +E + + A+ EQ
Sbjct: 187 CSELE---QQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243
Query: 1017 KRLKEAKIAL-EIVDKLSNQKVALEKQIE 1044
+ A AL E + K++N K++E
Sbjct: 244 DQAGSANQALSEDIRKVTNDWTRCRKELE 272
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 621 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 677
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 735
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 736 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 791
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 970 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 1029
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 1030 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 1081 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 1125
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 1126 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1243 KEQKLALLEEARTAV 1257
Score = 33.9 bits (74), Expect = 3.2
Identities = 32/144 (22%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 605 ITREKETQASELERSCQVIKQNGFELDKM--KADILMXXXXXXXXXXXXXXXXDEAKSLL 662
+ E + EL R ++ Q+ E D++ K + + E + L+
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
Query: 663 EQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLN 722
Q++ L+ Q +E+ R ++ +++ + Q +++ RLQ +I + K E E +L
Sbjct: 139 RQSVELRRQLQEEQASYRR---KLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL 195
Query: 723 ELTNKYEALK-RDYDAAVKDLESS 745
E + + E + RD + + +DLES+
Sbjct: 196 ERSGELEQQRLRDTEHS-QDLESA 218
>AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein
protein.
Length = 1173
Score = 60.1 bits (139), Expect = 4e-08
Identities = 163/865 (18%), Positives = 340/865 (39%), Gaps = 80/865 (9%)
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT--MDLDEKLG----------- 286
++I + +++L + +E K + +KN L+ E N++ M LD ++
Sbjct: 86 DQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEK 145
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+N+E E K KV LN L +K + +D +++ L L+ E + +
Sbjct: 146 DNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQE 203
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
E+L++ + Q+ D E + ++L+ + + + I+ N
Sbjct: 204 KSELLVEQ--GRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIK--NFHK 259
Query: 407 ILRIQKERIHEISSAVTIDIVKKEN----ELKEILTKECL--KLSKLKIDIPRDLDQDLP 460
++R ++E + ++ + D +KE ++ EI K+ ++ +LK +I +L
Sbjct: 260 LVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELK 319
Query: 461 AHK-KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD-TL 518
K ++ L + EL + + E+E + E + D TL
Sbjct: 320 NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTL 379
Query: 519 EEAHNEVKSLHEELTK------LYKSKVDENNANLNLIKILSEEIDALKIAIAKN---EE 569
+ E++ L+ T L K K D++ + S+E+ +L E+
Sbjct: 380 RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 439
Query: 570 KMLSLSEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ S S++ N+ + ++ +N L + +N+ + R++E +S ++ V F
Sbjct: 440 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 499
Query: 629 E--LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI 686
E LD++K +I L ++N + C+ + + L+ I
Sbjct: 500 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 559
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIE--------------KETKLNELTNKYEALK 732
+ + + + ++++ +K E KE ++ EL NK + +
Sbjct: 560 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 619
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
RD D+E + + +++ ++ + I +
Sbjct: 620 RDIQRLKNDIEEQETLLGTIMPEEE--SAKVCLTDVTIMERFQMELKDVERKIAQQAAKL 677
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQE-LDDLKERY 851
T N++ E D+ I +L +L+ QQE + LK
Sbjct: 678 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKI---------ELNRKLIQDQQEQIQHLKSTT 728
Query: 852 KELDDECETCAEYLQER---DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFAD 907
EL E + LQ R +EQ L E SL +++ + KEQ+ P+E KF
Sbjct: 729 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQV---SPLETTLEKFQQ 785
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEE-LRYKKQDL-KNTVTKMQKAM 964
+ + D+++ E KN MK IE ++ K D K T++ K +
Sbjct: 786 EKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVI 845
Query: 965 EKYTKKDKEFEAKRKELEDCKAEL--EELKQRYKELDEECETCAEYLKQREEQCKR-LKE 1021
+ ++ +K E +++ + ++ +++++R+ + + E LK+ EE+ K+ LKE
Sbjct: 846 AQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE 905
Query: 1022 AKIALEIVDKLSNQKVALEKQIESL 1046
+ K +QK LE+ I+++
Sbjct: 906 MGQMQVLQMKSEHQK--LEENIDNI 928
Score = 52.8 bits (121), Expect = 7e-06
Identities = 81/472 (17%), Positives = 191/472 (40%), Gaps = 39/472 (8%)
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
E+ SK + ++ ++K E+D LK + + E + + + DN++ L S
Sbjct: 83 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 142
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
++++N+ L+ + + + + Q ++L + Q + E ++ D
Sbjct: 143 MEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ---RTVREKERKLVDC------------- 186
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
E + L +++ L ++ E + RL++ H++ ++ +I L Q++ D
Sbjct: 187 ----HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELD 242
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL-ESD 769
F ++ N ++ ++ + K ++ + +N ++ L + +I E+ +
Sbjct: 243 G--FERGPFSERQIKNFHKLVRERQEGEAK---TANQLMNDFAEKETLKQKQIDEIRDKK 297
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ + G +R L + +L + + +S
Sbjct: 298 TGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSN 357
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
V LK ++S Q E DL ++LD E E + R Q L K+K ++Q+ +
Sbjct: 358 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR-TQMEMLTKDKADKDEQIRKI 416
Query: 890 KEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + + + F + EDW + S +++ + D + NK L +
Sbjct: 417 KSR-HSDELTSLLGYFPN--KKQLEDWLHSKSKEINQ-TRDRLAKLNKELASS----EQN 468
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
K + N + + ++ + Y +DK F+ +D +++L+ LK+ ++ ++
Sbjct: 469 KNHINNELKRKEEQLSSY--EDKLFDVCGS--QDFESDLDRLKEEIEKSSKQ 516
Score = 52.4 bits (120), Expect = 9e-06
Identities = 141/721 (19%), Positives = 303/721 (42%), Gaps = 78/721 (10%)
Query: 101 ETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTE 160
E +T + LM+ E E L K K+I + D KT +I EL+ E ++ + E
Sbjct: 268 EAKTANQLMNDFA--EKETL-KQKQIDEIRDK-KTGLGRIIELKSE------ILSKKQNE 317
Query: 161 SDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQC-KLKENLIQSLHIGY 219
N+ E+ L+ +++ + + +D E + E E KN + K++ +Q+
Sbjct: 318 LKNVKYELQQLEGSSDRILE--LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 375
Query: 220 DNTLSKLNRSISDSN--TSTRYNKICTLQSELDAGREDCK---ELCEDFTSIKNHLELHE 274
D TL KL++ + N T+TR + + D + K ++ TS+ + ++
Sbjct: 376 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFP-NK 434
Query: 275 PNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
+ L K E N+ + K+ E+ + + + INNE K+ ++ + Y+D L
Sbjct: 435 KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNH--INNELKRKEEQLSSYEDKLFD 492
Query: 335 VLDAEFGTTSLDVFEILMDN-------------IINKYQIDL-DE------ILEKYTKVQ 374
V ++ + LD + ++ + +++ L DE + ++ + +
Sbjct: 493 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE 552
Query: 375 GDLNECTSELKS----VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+L E S+L+S +KL S S+L +KE R + + + ++ ID+ +KE
Sbjct: 553 AELQEVISDLQSKLRLAPDKLKSTESELKKKEKR----RDEMLGLVPMRQSI-IDLKEKE 607
Query: 431 -NELKEILTKECLKLSKLKIDIPRD---LDQDLPAHKKITI-LFDALITQYELSRTDYEI 485
EL+ L + +LK DI L +P + + L D I + R E+
Sbjct: 608 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTI----MERFQMEL 663
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ + ++ AK +E +++ ++ ++ +L + + +
Sbjct: 664 KDVERKIAQQAAKLQGIDLDRTVQQVN---QEKQEKQHKLDTVSSKI-ELNRKLIQDQQE 719
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS---TINGLKEENNSLKSL 601
+ +K + E+ + K+ I+ N ++ L E+ +L TE+ S I KE+ + L++
Sbjct: 720 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETT 779
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ +EKE ++ S ++ + +L+ +K + D+ K
Sbjct: 780 LEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
Query: 662 LEQNL----ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI---MRLQKQIQEDDKLF 714
E L A +CE+ + ++ T +IQ R + + L+K+ +E ++
Sbjct: 837 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 896
Query: 715 IEKETKLNELTN-KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E++ L E+ + +K ++ +++++ + N ++ E I + ++R
Sbjct: 897 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
Query: 774 Q 774
Q
Sbjct: 957 Q 957
Score = 43.6 bits (98), Expect = 0.004
Identities = 115/629 (18%), Positives = 269/629 (42%), Gaps = 52/629 (8%)
Query: 26 QLDGAKSK----NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL 81
QL+G+ + + +I+ + K + + + SL+ +++ L KL E+
Sbjct: 327 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 386
Query: 82 FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK----DKEIKNLTDSLKTKS 137
+ + + + L + +D + +IKS + LT K L D L +KS
Sbjct: 387 EQLNHHTTT-RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKS 445
Query: 138 KKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIG 197
K+IN+ + D L+ L E + N N ++LK+ E L+ L + + +
Sbjct: 446 KEINQTR---DRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESD 502
Query: 198 PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS--TRYNKICTLQSELDAGRED 255
+ + + K + +++ G S+ ++D N S ++ ++EL D
Sbjct: 503 LDRLKEEIE-KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISD 561
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN 315
+ E DE LG ++ EI N L Q +N
Sbjct: 562 LQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL--QNVN 619
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE----ILEKYT 371
+ ++ K+ I+ +++LL + E + + + ++ I+ ++Q++L + I ++
Sbjct: 620 RDIQRLKNDIEE-QETLLGTIMPEEESAKVCLTDV---TIMERFQMELKDVERKIAQQAA 675
Query: 372 KVQG-DLNECTSEL-KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
K+QG DL+ ++ + EK L++ + E +++ Q+E+I + S T ++ +
Sbjct: 676 KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS-TTNELKSE 734
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
+ ++ L + +L + +++ ++ Q L +++I + ++ E + ++ EKE+
Sbjct: 735 KLQISTNLQRR-QQLEEQTVELSTEV-QSL--YREIKDAKEQ-VSPLETTLEKFQQEKEE 789
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXF--------DTLEEAHNEVKSLHE-ELTKLYK--S 538
L + T+ + + +++ ++ K E EL K+ S
Sbjct: 790 LINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 849
Query: 539 KVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNS 597
+ +++ +N ++++ ++ID KI ++ L+L +++ +L E+ +E
Sbjct: 850 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN-LTLRKRNEELKEVE------EERKQH 902
Query: 598 LKSLNDVITREKETQASELERSCQVIKQN 626
LK + + + +++ +LE + IK+N
Sbjct: 903 LKEMGQMQVLQMKSEHQKLEENIDNIKRN 931
Score = 40.3 bits (90), Expect = 0.037
Identities = 49/266 (18%), Positives = 119/266 (44%), Gaps = 21/266 (7%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+++++ KE + S + ELD LK R KE++ + + D + L K +E+
Sbjct: 92 EAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSK----IMKLDNEIKALDSRKKQMEKDN 147
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
S L+E+ +E+ + D +N D + H V R V+ ++ L K +E
Sbjct: 148 SELEEK------MEKVFQGTDEQLN---DLYHNHQRTV-REKERKLVDCHRELEKLNKES 197
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETC 1005
R Q+ + + + + + + A+ ++ +LE + +R + + +
Sbjct: 198 RLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNF 257
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
+ +++R+E EAK A ++++ + ++ +KQI+ + + + +
Sbjct: 258 HKLVRERQE-----GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILS 312
Query: 1066 QNQ-QITDVMKENQKLKKMNAKLITI 1090
+ Q ++ +V E Q+L+ + +++ +
Sbjct: 313 KKQNELKNVKYELQQLEGSSDRILEL 338
Score = 35.5 bits (78), Expect = 1.1
Identities = 78/394 (19%), Positives = 157/394 (39%), Gaps = 35/394 (8%)
Query: 66 SSNEINLKL-EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S E+N KL + ++ +K + L+ + + Q R L Q L E + +
Sbjct: 705 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR 764
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSN-LIMENVTESDNLN------KEVDDLKKNNEC 177
EIK+ + + + + Q+E + L N N D LN K + K+ E
Sbjct: 765 EIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 824
Query: 178 LTQKCIDLEKLVNESE-NK-IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT 235
Q D K E+E NK I + C + K K N L +T R + D+ T
Sbjct: 825 YIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLT 884
Query: 236 STRYNKICTLQSELDAGREDCKELCE-DFTSIKN-HLELHE--PNMTMDLDEKLGENNEF 291
+ N+ L+ + ++ KE+ + +K+ H +L E N+ + + LG +
Sbjct: 885 LRKRNE--ELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGY 942
Query: 292 ETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL 351
E + + E++ + +D ++Y++ ++ + E LD++
Sbjct: 943 EEEIIHFKKELR--------------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKT 988
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
+D I K+ +E+ K+ DL T + + + + S E +A + R
Sbjct: 989 LDQAIMKFH---SMKMEEINKIIRDLWRSTYRGQDI--EYIEIRSDADENVSASDKRRNY 1043
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLS 445
R+ + +D+ + + +++L ++L+
Sbjct: 1044 NYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLA 1077
>AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein.
Length = 1312
Score = 60.1 bits (139), Expect = 4e-08
Identities = 163/865 (18%), Positives = 340/865 (39%), Gaps = 80/865 (9%)
Query: 240 NKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMT--MDLDEKLG----------- 286
++I + +++L + +E K + +KN L+ E N++ M LD ++
Sbjct: 225 DQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEK 284
Query: 287 ENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLD 346
+N+E E K KV LN L +K + +D +++ L L+ E + +
Sbjct: 285 DNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQE 342
Query: 347 VFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACN 406
E+L++ + Q+ D E + ++L+ + + + I+ N
Sbjct: 343 KSELLVEQ--GRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIK--NFHK 398
Query: 407 ILRIQKERIHEISSAVTIDIVKKEN----ELKEILTKECL--KLSKLKIDIPRDLDQDLP 460
++R ++E + ++ + D +KE ++ EI K+ ++ +LK +I +L
Sbjct: 399 LVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELK 458
Query: 461 AHK-KITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD-TL 518
K ++ L + EL + + E+E + E + D TL
Sbjct: 459 NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTL 518
Query: 519 EEAHNEVKSLHEELTK------LYKSKVDENNANLNLIKILSEEIDALKIAIAKN---EE 569
+ E++ L+ T L K K D++ + S+E+ +L E+
Sbjct: 519 RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 578
Query: 570 KMLSLSEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGF 628
+ S S++ N+ + ++ +N L + +N+ + R++E +S ++ V F
Sbjct: 579 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 638
Query: 629 E--LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINI 686
E LD++K +I L ++N + C+ + + L+ I
Sbjct: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
Query: 687 KTHEKTAEIQNRMIMRLQKQIQEDDKLFIE--------------KETKLNELTNKYEALK 732
+ + + + ++++ +K E KE ++ EL NK + +
Sbjct: 699 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 758
Query: 733 RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXX 792
RD D+E + + +++ ++ + I +
Sbjct: 759 RDIQRLKNDIEEQETLLGTIMPEEE--SAKVCLTDVTIMERFQMELKDVERKIAQQAAKL 816
Query: 793 XXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQE-LDDLKERY 851
T N++ E D+ I +L +L+ QQE + LK
Sbjct: 817 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKI---------ELNRKLIQDQQEQIQHLKSTT 867
Query: 852 KELDDECETCAEYLQER---DEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQ-AKFAD 907
EL E + LQ R +EQ L E SL +++ + KEQ+ P+E KF
Sbjct: 868 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQV---SPLETTLEKFQQ 924
Query: 908 VAVNTDEDWANLHSVVVDRMSYDAEVEKN-KRLMKTIEE-LRYKKQDL-KNTVTKMQKAM 964
+ + D+++ E KN MK IE ++ K D K T++ K +
Sbjct: 925 EKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVI 984
Query: 965 EKYTKKDKEFEAKRKELEDCKAEL--EELKQRYKELDEECETCAEYLKQREEQCKR-LKE 1021
+ ++ +K E +++ + ++ +++++R+ + + E LK+ EE+ K+ LKE
Sbjct: 985 AQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE 1044
Query: 1022 AKIALEIVDKLSNQKVALEKQIESL 1046
+ K +QK LE+ I+++
Sbjct: 1045 MGQMQVLQMKSEHQK--LEENIDNI 1067
Score = 52.8 bits (121), Expect = 7e-06
Identities = 81/472 (17%), Positives = 191/472 (40%), Gaps = 39/472 (8%)
Query: 531 ELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTING 590
E+ SK + ++ ++K E+D LK + + E + + + DN++ L S
Sbjct: 222 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 281
Query: 591 LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXX 650
++++N+ L+ + + + + Q ++L + Q + E ++ D
Sbjct: 282 MEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ---RTVREKERKLVDC------------- 325
Query: 651 XXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED 710
E + L +++ L ++ E + RL++ H++ ++ +I L Q++ D
Sbjct: 326 ----HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELD 381
Query: 711 DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL-ESD 769
F ++ N ++ ++ + K ++ + +N ++ L + +I E+ +
Sbjct: 382 G--FERGPFSERQIKNFHKLVRERQEGEAK---TANQLMNDFAEKETLKQKQIDEIRDKK 436
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
+ + G +R L + +L + + +S
Sbjct: 437 TGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSN 496
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
V LK ++S Q E DL ++LD E E + R Q L K+K ++Q+ +
Sbjct: 497 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR-TQMEMLTKDKADKDEQIRKI 555
Query: 890 KEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
K + + + F + EDW + S +++ + D + NK L +
Sbjct: 556 KSR-HSDELTSLLGYFPN--KKQLEDWLHSKSKEINQ-TRDRLAKLNKELASS----EQN 607
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
K + N + + ++ + Y +DK F+ +D +++L+ LK+ ++ ++
Sbjct: 608 KNHINNELKRKEEQLSSY--EDKLFDVCGS--QDFESDLDRLKEEIEKSSKQ 655
Score = 52.4 bits (120), Expect = 9e-06
Identities = 141/721 (19%), Positives = 303/721 (42%), Gaps = 78/721 (10%)
Query: 101 ETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTE 160
E +T + LM+ E E L K K+I + D KT +I EL+ E ++ + E
Sbjct: 407 EAKTANQLMNDFA--EKETL-KQKQIDEIRDK-KTGLGRIIELKSE------ILSKKQNE 456
Query: 161 SDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQC-KLKENLIQSLHIGY 219
N+ E+ L+ +++ + + +D E + E E KN + K++ +Q+
Sbjct: 457 LKNVKYELQQLEGSSDRILE--LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 514
Query: 220 DNTLSKLNRSISDSN--TSTRYNKICTLQSELDAGREDCK---ELCEDFTSIKNHLELHE 274
D TL KL++ + N T+TR + + D + K ++ TS+ + ++
Sbjct: 515 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFP-NK 573
Query: 275 PNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
+ L K E N+ + K+ E+ + + + INNE K+ ++ + Y+D L
Sbjct: 574 KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNH--INNELKRKEEQLSSYEDKLFD 631
Query: 335 VLDAEFGTTSLDVFEILMDN-------------IINKYQIDL-DE------ILEKYTKVQ 374
V ++ + LD + ++ + +++ L DE + ++ + +
Sbjct: 632 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE 691
Query: 375 GDLNECTSELKS----VNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKE 430
+L E S+L+S +KL S S+L +KE R + + + ++ ID+ +KE
Sbjct: 692 AELQEVISDLQSKLRLAPDKLKSTESELKKKEKR----RDEMLGLVPMRQSI-IDLKEKE 746
Query: 431 -NELKEILTKECLKLSKLKIDIPRD---LDQDLPAHKKITI-LFDALITQYELSRTDYEI 485
EL+ L + +LK DI L +P + + L D I + R E+
Sbjct: 747 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTI----MERFQMEL 802
Query: 486 EKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNA 545
+ + ++ AK +E +++ ++ ++ +L + + +
Sbjct: 803 KDVERKIAQQAAKLQGIDLDRTVQQVN---QEKQEKQHKLDTVSSKI-ELNRKLIQDQQE 858
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKL-TELVS---TINGLKEENNSLKSL 601
+ +K + E+ + K+ I+ N ++ L E+ +L TE+ S I KE+ + L++
Sbjct: 859 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETT 918
Query: 602 NDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSL 661
+ +EKE ++ S ++ + +L+ +K + D+ K
Sbjct: 919 LEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
Query: 662 LEQNL----ALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMI---MRLQKQIQEDDKLF 714
E L A +CE+ + ++ T +IQ R + + L+K+ +E ++
Sbjct: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 1035
Query: 715 IEKETKLNELTN-KYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTE 773
E++ L E+ + +K ++ +++++ + N ++ E I + ++R
Sbjct: 1036 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
Query: 774 Q 774
Q
Sbjct: 1096 Q 1096
Score = 43.6 bits (98), Expect = 0.004
Identities = 115/629 (18%), Positives = 269/629 (42%), Gaps = 52/629 (8%)
Query: 26 QLDGAKSK----NDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGEL 81
QL+G+ + + +I+ + K + + + SL+ +++ L KL E+
Sbjct: 466 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 525
Query: 82 FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK----DKEIKNLTDSLKTKS 137
+ + + + L + +D + +IKS + LT K L D L +KS
Sbjct: 526 EQLNHHTTT-RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKS 584
Query: 138 KKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIG 197
K+IN+ + D L+ L E + N N ++LK+ E L+ L + + +
Sbjct: 585 KEINQTR---DRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESD 641
Query: 198 PKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTS--TRYNKICTLQSELDAGRED 255
+ + + K + +++ G S+ ++D N S ++ ++EL D
Sbjct: 642 LDRLKEEIE-KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISD 700
Query: 256 CKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLIN 315
+ E DE LG ++ EI N L Q +N
Sbjct: 701 LQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL--QNVN 758
Query: 316 NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDE----ILEKYT 371
+ ++ K+ I+ +++LL + E + + + ++ I+ ++Q++L + I ++
Sbjct: 759 RDIQRLKNDIEE-QETLLGTIMPEEESAKVCLTDV---TIMERFQMELKDVERKIAQQAA 814
Query: 372 KVQG-DLNECTSEL-KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
K+QG DL+ ++ + EK L++ + E +++ Q+E+I + S T ++ +
Sbjct: 815 KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS-TTNELKSE 873
Query: 430 ENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEK 489
+ ++ L + +L + +++ ++ Q L +++I + ++ E + ++ EKE+
Sbjct: 874 KLQISTNLQRR-QQLEEQTVELSTEV-QSL--YREIKDAKEQ-VSPLETTLEKFQQEKEE 928
Query: 490 LRLETGTAKAVXXXXXXXXXXXXXXF--------DTLEEAHNEVKSLHE-ELTKLYK--S 538
L + T+ + + +++ ++ K E EL K+ S
Sbjct: 929 LINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 988
Query: 539 KVDENNANLNL-IKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNS 597
+ +++ +N ++++ ++ID KI ++ L+L +++ +L E+ +E
Sbjct: 989 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN-LTLRKRNEELKEVE------EERKQH 1041
Query: 598 LKSLNDVITREKETQASELERSCQVIKQN 626
LK + + + +++ +LE + IK+N
Sbjct: 1042 LKEMGQMQVLQMKSEHQKLEENIDNIKRN 1070
Score = 40.3 bits (90), Expect = 0.037
Identities = 49/266 (18%), Positives = 119/266 (44%), Gaps = 21/266 (7%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+++++ KE + S + ELD LK R KE++ + + D + L K +E+
Sbjct: 231 EAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSK----IMKLDNEIKALDSRKKQMEKDN 286
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
S L+E+ +E+ + D +N D + H V R V+ ++ L K +E
Sbjct: 287 SELEEK------MEKVFQGTDEQLN---DLYHNHQRTV-REKERKLVDCHRELEKLNKES 336
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE-ELKQRYKELDEECETC 1005
R Q+ + + + + + + A+ ++ +LE + +R + + +
Sbjct: 337 RLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNF 396
Query: 1006 AEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIV 1065
+ +++R+E EAK A ++++ + ++ +KQI+ + + + +
Sbjct: 397 HKLVRERQE-----GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILS 451
Query: 1066 QNQ-QITDVMKENQKLKKMNAKLITI 1090
+ Q ++ +V E Q+L+ + +++ +
Sbjct: 452 KKQNELKNVKYELQQLEGSSDRILEL 477
Score = 35.5 bits (78), Expect = 1.1
Identities = 78/394 (19%), Positives = 157/394 (39%), Gaps = 35/394 (8%)
Query: 66 SSNEINLKL-EKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
S E+N KL + ++ +K + L+ + + Q R L Q L E + +
Sbjct: 844 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR 903
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSN-LIMENVTESDNLN------KEVDDLKKNNEC 177
EIK+ + + + + Q+E + L N N D LN K + K+ E
Sbjct: 904 EIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 963
Query: 178 LTQKCIDLEKLVNESE-NK-IGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT 235
Q D K E+E NK I + C + K K N L +T R + D+ T
Sbjct: 964 YIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLT 1023
Query: 236 STRYNKICTLQSELDAGREDCKELCE-DFTSIKN-HLELHE--PNMTMDLDEKLGENNEF 291
+ N+ L+ + ++ KE+ + +K+ H +L E N+ + + LG +
Sbjct: 1024 LRKRNE--ELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGY 1081
Query: 292 ETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEIL 351
E + + E++ + +D ++Y++ ++ + E LD++
Sbjct: 1082 EEEIIHFKKELR--------------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKT 1127
Query: 352 MDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQ 411
+D I K+ +E+ K+ DL T + + + + S E +A + R
Sbjct: 1128 LDQAIMKFH---SMKMEEINKIIRDLWRSTYRGQDI--EYIEIRSDADENVSASDKRRNY 1182
Query: 412 KERIHEISSAVTIDIVKKENELKEILTKECLKLS 445
R+ + +D+ + + +++L ++L+
Sbjct: 1183 NYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLA 1216
>AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein.
Length = 1919
Score = 60.1 bits (139), Expect = 4e-08
Identities = 90/420 (21%), Positives = 183/420 (43%), Gaps = 46/420 (10%)
Query: 659 KSLLEQNLAL-KEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK 717
KS L +L + ++Q EE ++ +L+ E+ ++R+ + +Q+ ++ E
Sbjct: 507 KSNLAHSLQVAQQQAEELRQEREKLQA---AQEELRRQRDRLEEEQEDAVQDGARVRREL 563
Query: 718 ETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTAT 777
E +L E L+ K+L REA+++ T Q+D+++ AE+ + +
Sbjct: 564 ERSHRQL----EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 619
Query: 778 VXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERL 837
V N L ++ KLD R ++ + + E S L+ R
Sbjct: 620 VELELSMTKLRAEEASLQDSLSKLSALNESLAQD-KLD--LNRLVAQL-EEEKSALQGRQ 675
Query: 838 LSCQQELD---DLKERYKELDDECETC----------AEYLQER-DEQCARLKKEKLSLE 883
+QE + +ER +EL E E AE QE ++Q L+ E+ L+
Sbjct: 676 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQ 735
Query: 884 QQVSNLKEQI--------RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEK 935
+Q++ L Q+ + ++ +RQ + + A E A H+ + ++ A +
Sbjct: 736 EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV--AAERE 793
Query: 936 NKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL----EDCKAELEEL 991
+ L + LR +K+ L+ ++ ++Q+ + + + ++ EA+ + L E EL L
Sbjct: 794 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 853
Query: 992 KQRYKELDEECETCAEYLKQREEQCKR-----LKEAKIA-LEIVDKLSNQKVALEKQIES 1045
+Q+ E+ E + Q+ Q +R L+E + A E + +L +K A +++E+
Sbjct: 854 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 913
Score = 52.0 bits (119), Expect = 1e-05
Identities = 86/421 (20%), Positives = 176/421 (41%), Gaps = 41/421 (9%)
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQ----NRMIMRLQKQIQEDDKL 713
A++ LE+ L+ Q EE+ RD E ++ + +++ + + L ++ +K
Sbjct: 255 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 314
Query: 714 FIEKETKLNELTNKYEALK--RDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIR 771
+EK+ +LT K EAL+ R + A + E E + Q T +DL + +++ ES ++
Sbjct: 315 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDG-EGLQQ--TLRDLAQAVLSDSESGVQ 371
Query: 772 ---TEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSP---------- 818
+E+TA + G +P DS
Sbjct: 372 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 431
Query: 819 KRSISV--------ISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDE 870
KR + V S + L+++L + E L+E+ + L D+ + + ++
Sbjct: 432 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 491
Query: 871 QCARLKKEKLSLEQQVSNLKE--QIRTQQPVERQAKFADVAVNTDE---DWANLHSVVVD 925
+ RL+ L ++ SNL Q+ QQ E + + + +E L D
Sbjct: 492 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 551
Query: 926 RMSYDAEVEKN-KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDC 984
+ A V + +R + +E+L K+ L + ++++A+ + T + +A++ E+ +
Sbjct: 552 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 611
Query: 985 KAELE----ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIAL-EIVDKLSNQKVAL 1039
+ E EL+ +L E + + L + + L + K+ L +V +L +K AL
Sbjct: 612 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 671
Query: 1040 E 1040
+
Sbjct: 672 Q 672
Score = 50.8 bits (116), Expect = 3e-05
Identities = 64/337 (18%), Positives = 144/337 (42%), Gaps = 19/337 (5%)
Query: 716 EKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
E T+ + L + ++ + D+A ++AV + + V+GR++ +++++ ++
Sbjct: 1429 ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE 1488
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
+ E R K+ + D +LKE
Sbjct: 1489 SVRRSERERRATLDQVATLERSLQATESELR--ASQEKISKMKANETKLEGDKR--RLKE 1544
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L + + L+ + + L+ E + L +R+ Q L+ SL++QV++ + + T
Sbjct: 1545 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1604
Query: 896 -QQPVER-QAKFADVAVN----TDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK 949
Q VER A V + D+ ++ S ++ +KN L K + +
Sbjct: 1605 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1664
Query: 950 KQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYL 1009
+Q L+ ++ A + ++ K+ + ++++ + E+ +L+ + E + + + E L
Sbjct: 1665 RQVLQE---RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1721
Query: 1010 KQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
+QR+E EA AL V KL +++ L++++ SL
Sbjct: 1722 RQRQE-----GEA-AALNTVQKLQDERRLLQERLGSL 1752
Score = 43.6 bits (98), Expect = 0.004
Identities = 140/794 (17%), Positives = 312/794 (39%), Gaps = 62/794 (7%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDL 281
L L + +SDS + R L+ +L R+ + + ++ L N +
Sbjct: 451 LGTLRKQLSDSESERR-----ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 505
Query: 282 DEK-LGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEF 340
++ L + + + + + + + L + E+L + ++ D +D + E
Sbjct: 506 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 565
Query: 341 GTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIE 400
L+ E +++ K +++ E L + T +Q D+ + +E V E L + +E
Sbjct: 566 SHRQLEQLEGKR-SVLAKELVEVREALSRAT-LQRDMLQ--AEKAEVAEALTKAEAGRVE 621
Query: 401 KENACNILRIQKERIHE-IS--SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQ 457
E + LR ++ + + +S SA+ + + + +L ++ + + S L+ R +Q
Sbjct: 622 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ-GRQRQAEQ 680
Query: 458 DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDT 517
+ ++ + L + E++R E LR+ +A+ +
Sbjct: 681 EATVAREEQERLEELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQ 737
Query: 518 LEEAHNEVKSLHEELTKLYKS---KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L + ++ +EL + + +V+ + L++E L + + E + +L
Sbjct: 738 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 797
Query: 575 SEKDNKLTELVSTING-LKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKM 633
SE+ +L + G L E L L + + E + L + + + EL +
Sbjct: 798 SEEATRLRLEKEALEGSLFEVQRQLAQL-EARREQLEAEGQALLLAKETLTG---ELAGL 853
Query: 634 KADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTA 693
+ I+ +A+ E +L+EQ D RL+ + +
Sbjct: 854 RQQIIATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQRLQREKEAAWREL 911
Query: 694 EIQNRMIMRLQKQIQ-EDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQL 752
E + +LQ Q+Q E ++L E + EL+ + AL+++ D + ES ++ Q
Sbjct: 912 EAERA---QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQ---QA 965
Query: 753 TTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ K+ + ++E R AT+ + RD
Sbjct: 966 LSLKESEKTALSEKLMGTR-HSLATISLEMER-------------------QKRDAQSRQ 1005
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ D S +++ +Q +E + QE+ L+E+ ++L + ++C +E Q
Sbjct: 1006 EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL 1065
Query: 873 ARLKKEKLSLEQQVSNLKEQIR-TQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDA 931
L+ + L +++ + ++R +Q+ E Q + A + + A + R S +
Sbjct: 1066 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL--RRSNEE 1123
Query: 932 EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELE----DCKAE 987
K+ L+ +D + + +++A K+ E +E+E + + E
Sbjct: 1124 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1183
Query: 988 LEELKQRYKELDEE 1001
L+EL+++ K LD E
Sbjct: 1184 LQELRRQMKMLDSE 1197
Score = 42.7 bits (96), Expect = 0.007
Identities = 74/396 (18%), Positives = 155/396 (39%), Gaps = 25/396 (6%)
Query: 660 SLLEQNLALKEQCEEKTRD-CSRLEINIKTHEKTAEIQNRMI--MRLQKQIQEDDKLFIE 716
+L E+++ E+ T D + LE +++ E I M+ + E DK ++
Sbjct: 1484 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1543
Query: 717 KETKLNEL-TNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
+ +E T K E +R + +L+ SR ++ Q ++ R+ L+ + +
Sbjct: 1544 EVLDASESRTVKLELQRRSLEG---ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1600
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
D+ R L E L S S++ D + L++
Sbjct: 1601 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE--ALAQS-SASLNSTRDKNL-HLQK 1656
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT 895
L +C+ + L+ER + EQ L+ E LE Q + Q++
Sbjct: 1657 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1716
Query: 896 QQPVERQAKFAD-VAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLK 954
+ V RQ + + A+NT + + ++ +R+ L + + +L +K++++
Sbjct: 1717 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLG---------SLQRALAQLEAEKREVE 1767
Query: 955 NTVTKMQKAMEKYTKK-DKEFEAKRKELED---CKAELEELKQRYKELDEECETCAEYLK 1010
+ +++K + DK K + ED AE L + + E ++
Sbjct: 1768 RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1827
Query: 1011 QREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
Q E Q L+++ ++ Q++ L++++E L
Sbjct: 1828 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERL 1863
Score = 39.9 bits (89), Expect = 0.049
Identities = 96/481 (19%), Positives = 205/481 (42%), Gaps = 55/481 (11%)
Query: 159 TESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGP-----KNICAQCKLKENLIQ 213
T++ LN+++ +++ + T + L+K V ESE + A+ L+E ++
Sbjct: 1432 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVR 1491
Query: 214 SLHIGYDNTLSK---LNRSISDSNTSTR-----YNKICTLQSELDAGREDCKELCEDFTS 265
TL + L RS+ + + R +K+ +++L+ + KE+ + S
Sbjct: 1492 RSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES 1551
Query: 266 IKNHLELHEPNMTMDLD-EKLG-ENNEFETKAVK----------VMSEIKRNLNSLSEQL 313
LEL ++ +L +LG + E + +A++ SE+K L+ +
Sbjct: 1552 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1611
Query: 314 INNESKKSKDHIDRYKDSLLAVLDA-EFGTTSLDVF---EILMDNIINKYQIDLDEILEK 369
+N K ++ +D + + +A + SL+ + + + + D + E+
Sbjct: 1612 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1671
Query: 370 YTKVQGDLNECTSELKSVNE-------KLASLNSQLIEKENACNILRIQKERIHEISSAV 422
+ L+E + S+ E ++A L Q +E E LR + R + A
Sbjct: 1672 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQEGEAA 1730
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
++ V+K + + +L + +L L+ + + L+ + ++ + + + L RT
Sbjct: 1731 ALNTVQKLQDERRLLQE---RLGSLQRALAQ-LEAEKREVERSALRLEK--DRVALRRTL 1784
Query: 483 YEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVD- 541
++E+EKLR T + + L EA +++ L ++ L +S
Sbjct: 1785 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE-LAEAQRQIQQLEAQVVVLEQSHSPA 1843
Query: 542 --ENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNK-----LTELVSTING-LKE 593
E +A ++ L +E++ L+ A A+ E+ L E+ ++ L E VST+ G L++
Sbjct: 1844 QLEVDAQQQQLE-LQQEVERLRSAQAQT-ERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1901
Query: 594 E 594
E
Sbjct: 1902 E 1902
Score = 39.9 bits (89), Expect = 0.049
Identities = 78/405 (19%), Positives = 165/405 (40%), Gaps = 31/405 (7%)
Query: 61 QSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENL 120
+SL+ + +E+ EK+S +K ++ LEG + L + D S+ LE++
Sbjct: 1509 RSLQATESELRASQEKIS----KMKANETKLEGDKRRL---KEVLDASESRTVKLELQRR 1561
Query: 121 TKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQ 180
+ + E++ L + + LQ+ D+L + ++ ++ L V+ L N L +
Sbjct: 1562 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERL---NGALAK 1618
Query: 181 KCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN 240
V ESE + K L E L QS ++T K N + + T+ ++
Sbjct: 1619 --------VEESEGALRDK----VRGLTEALAQS-SASLNSTRDK-NLHLQKALTACEHD 1664
Query: 241 KICTLQSELDAGREDCKELCEDFTSIKNHLE-LHEPNMTMDLDEKLGENNEFETKAVKVM 299
+ LQ LDA R+ E + +S+ ++ L ++L E + + V
Sbjct: 1665 R-QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1723
Query: 300 SEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKY 359
+ + Q + +E + ++ + + + LA L+AE + D +
Sbjct: 1724 RQEGEAAALNTVQKLQDERRLLQERLGSLQRA-LAQLEAEKREVERSALRLEKDRV--AL 1780
Query: 360 QIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEIS 419
+ LD++ + + D ++E ++ L +L E + L Q + +
Sbjct: 1781 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH 1840
Query: 420 SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKK 464
S +++ ++ +L+ L +E +L + R L+ AH++
Sbjct: 1841 SPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTLEARERAHRQ 1883
Score = 36.7 bits (81), Expect = 0.46
Identities = 120/675 (17%), Positives = 280/675 (41%), Gaps = 69/675 (10%)
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ EKL + +L + + L ++E + + V ++ + +L+++ K +
Sbjct: 523 ELRQEREKLQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 579
Query: 443 ---KLSKLKIDIPR-DLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAK 498
+L +++ + R L +D+ +K + +AL T+ E R + E+ KLR E + +
Sbjct: 580 LAKELVEVREALSRATLQRDMLQAEKAEVA-EAL-TKAEAGRVELELSMTKLRAEEASLQ 637
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
D L+ + V L EE + L + + + + + E ++
Sbjct: 638 --DSLSKLSALNESLAQDKLD-LNRLVAQLEEEKSAL-QGRQRQAEQEATVAREEQERLE 693
Query: 559 ALKIA--IAKNE-EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
L++ +A+ E L ++E+ + E + L+ E + L+ ++R+ + E
Sbjct: 694 ELRLEQEVARQGLEGSLRVAEQAQEALE--QQLPTLRHERSQLQEQLAQLSRQLSGREQE 751
Query: 616 LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLAL---KEQC 672
LE++ + ++ L++ + E ++L E+ L KE
Sbjct: 752 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 811
Query: 673 EEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQED------DKLFIEKETKLNE--L 724
E + R ++ + E + + ++ ++ + + + +++ L++ +
Sbjct: 812 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 871
Query: 725 TNKYEALKRDYDAAVKDLESSREA-VNQLTTQKDL----VEGRIAELESDIRTEQTATVX 779
K +R+ A++++ ++ E + +L +K+ +E A+L+S ++ EQ +
Sbjct: 872 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 931
Query: 780 XXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLS 839
+ RD E L +S K+ + +SE + L E+L+
Sbjct: 932 RLEAEKEELSEEIAAL-------QQERD--EGLLLAESEKQQALSLKESEKTALSEKLMG 982
Query: 840 CQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPV 899
+ L + + Q+RD Q +R ++++ ++ S L++ +R Q+
Sbjct: 983 TRHSLATISLEMER------------QKRDAQ-SRQEQDRSTVNALTSELRD-LRAQRE- 1027
Query: 900 ERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYK-KQDLKNTVT 958
E A A E +L R S E E+ + ++ +E+ R +++L
Sbjct: 1028 EAAAAHAQEVRRLQEQARDLGK---QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1084
Query: 959 KMQKAME-KYTKKDKEFEAKR------KELEDCKAELEELKQRYKELDEECETCAEYLKQ 1011
K++++ E + ++ + E +R KE E + EEL+ K+ + E + +
Sbjct: 1085 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1144
Query: 1012 REEQCKRLKEAKIAL 1026
+E++ L+EA+ A+
Sbjct: 1145 KEQKLALLEEARTAV 1159
Score = 32.7 bits (71), Expect = 7.5
Identities = 24/90 (26%), Positives = 50/90 (55%), Gaps = 5/90 (5%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
E + L+ Q++ L+ Q +E+ R ++ +++ + Q +++ RLQ +I + K E
Sbjct: 35 EPRGLVRQSVELRRQLQEEQASYRR---KLQAYQEGQQRQAQLVQRLQGKILQYKKRCSE 91
Query: 717 KETKLNELTNKYEALK-RDYDAAVKDLESS 745
E +L E + + E + RD + + +DLES+
Sbjct: 92 LEQQLLERSGELEQQRLRDTEHS-QDLESA 120
>X63105-1|CAA44819.1| 726|Homo sapiens Tpr protein.
Length = 726
Score = 59.7 bits (138), Expect = 6e-08
Identities = 138/727 (18%), Positives = 293/727 (40%), Gaps = 43/727 (5%)
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN--ESKKSK 322
S++N LE + ++D G + +F+ ++ + EI++ L+ E+L+N E + +
Sbjct: 20 SVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLR 79
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTS 382
+++ + L A+ + I + + + + +L+ EK ++ + +
Sbjct: 80 LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA--EKRDLIRTN-ERLSQ 136
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ + E + LN +L E L+++ + + +V + E E KE+L +
Sbjct: 137 ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE-KELLHSQNT 195
Query: 443 KLS---KLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA 499
L+ K K D L ++ ++ + + + + E+SR + ++ K E K
Sbjct: 196 WLNTELKTKTDELLALGRE-KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH-LQKH 253
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN-LIKILSEEID 558
V E+ HNE+ + H +L+ LYKS D++ A N L + + E
Sbjct: 254 VEDLLTKLKEAKEQQASMEEKFHNELNA-HIKLSNLYKSAADDSEAKSNELTRAVEELHK 312
Query: 559 ALKIAIAKN---EEKMLSLSE-KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
LK A N ++ +L + + KD E++ I L++E L++ ND+++ K A
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE---LENANDLLSATKRKGAI 369
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
E + + K+ + E N L E +E
Sbjct: 370 LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
L+ + +E+ + + ++L++ ++E +L E K N+ ++ E R
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL-QEDTDKANKQSSVLERDNRR 488
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ VKDL + L+E A IR E+ ++
Sbjct: 489 MEIQVKDLSQQIRVL--------LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKEL 854
R L +L ++ +R + S++++L+ +L S EL+ L+ K
Sbjct: 541 RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR---KSR 597
Query: 855 DDECETCAEYLQERDEQCARLKK--------EKLSLEQ-QVSNLKEQIRTQQPVERQAKF 905
+ + +++RD L + SL+ +++ ++ T Q V A
Sbjct: 598 QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPV 657
Query: 906 ADV-AVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM-KTIEELRYKKQDLKNTVTKMQKA 963
+ + E A L + +Y E +N+++ + +E+L+ + DL++ TK+
Sbjct: 658 PVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717
Query: 964 MEKYTKK 970
++ +K+
Sbjct: 718 LDFASKR 724
Score = 59.7 bits (138), Expect = 6e-08
Identities = 101/427 (23%), Positives = 185/427 (43%), Gaps = 32/427 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEI 436
E ++K++
Sbjct: 490 EIQVKDL 496
Score = 47.2 bits (107), Expect = 3e-04
Identities = 100/473 (21%), Positives = 196/473 (41%), Gaps = 47/473 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
K A L+ + + A + +I K + +++ + ++ L E L E +++K
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGM-KLTELYNAYVETQDQLLLEKL--ENKRINKY 422
Query: 448 KIDIPRDLDQDLPAHKKITILFD-ALITQYELSRTDYEIEKEKLRLETGTAKA 499
+I ++++ P K+ ++ A LS + KE RL+ T KA
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein.
Length = 709
Score = 59.7 bits (138), Expect = 6e-08
Identities = 111/580 (19%), Positives = 227/580 (39%), Gaps = 30/580 (5%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + +++ L + + K +DE + + I LSEE D L +
Sbjct: 102 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCG 161
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K TE + L E K+ + +E E + +L Q ++Q EL +++
Sbjct: 162 SPGMKRTE---SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 218
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINI-KTHEKTA 693
+ + DE +L E+ + + + E +R RL +I K +
Sbjct: 219 ENM----NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 274
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ N++++ + +++ + + KL+EL + LK A + D+E R+ +
Sbjct: 275 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK----AKLHDMEMERDMDRKKI 330
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
++L+E + LE + ++ + G E +L +
Sbjct: 331 --EELMEENMT-LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 387
Query: 814 L-----DDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
L + S +++ + + V ++L ++E L ++ + L++E + LQ
Sbjct: 388 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ 447
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
L KEK LE+ + L+E Q + Q + T + +
Sbjct: 448 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEA 505
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA 986
D E E NK L ++I+E K ++ +++K +E Y +K + E EL +
Sbjct: 506 RVKDIEKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 564
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
E E L+++ L CE ++ E + ++ K L+ L+ Q +LEK+ L
Sbjct: 565 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 624
Query: 1047 --SNTPVSNSTMYVATGSAIVQNQQI--TDVMKENQKLKK 1082
N + + + S + Q+ ++ E ++LKK
Sbjct: 625 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 664
Score = 54.0 bits (124), Expect = 3e-06
Identities = 100/573 (17%), Positives = 230/573 (40%), Gaps = 67/573 (11%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLI------KILSEEIDALKIAIAKNEEKM 571
LEE ++ +EL ++ N+NL+ ++ +E+DAL+ + ++
Sbjct: 192 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK-- 249
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
L + ++ E + I K LK N V+ K +LE + + +L
Sbjct: 250 --LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT----RARSDKLH 303
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
+++ + L + + L+E+N+ L+ ++ + L ++ +
Sbjct: 304 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 363
Query: 692 TAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
T+E+ L ++ E ++ E + LT E L+ D+ +E + +
Sbjct: 364 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS----VEGNASKIL 419
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
++ + + ++ LE++I E+ + T
Sbjct: 420 KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET---------- 469
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-RYKELDDECETCAEYLQERD 869
L ++ +R I ++ + E L + + S +Q E R K+++ E + E ++E
Sbjct: 470 ---LRENSERQIKIL-EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 525
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ ++++ EK +++++ + KE+ + +E + LH + +
Sbjct: 526 SKLSKIEFEKRQIKKELEHYKEKGERAEELENE----------------LHHLEKENELL 569
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ K + IE L + +L+ K++K ++ + K+ F+ + E E+ + + E
Sbjct: 570 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF--KNLTFQLESLEKENSQLDEE 627
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
L+ R E LK C +K A++ LE +L ++K L+K +E L +
Sbjct: 628 NLELRRN---------VESLK-----CASMKMAQLQLE-NKELESEKEQLKKGLELLKAS 672
Query: 1050 PVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
+ V+ ++NQ++ ++ + K KK
Sbjct: 673 FKKTERLEVSYQGLDIENQRLQKTLENSNKKKK 705
Score = 53.6 bits (123), Expect = 4e-06
Identities = 103/471 (21%), Positives = 204/471 (43%), Gaps = 45/471 (9%)
Query: 41 QSNPIKLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEG-KYQ 96
Q N L D+ + + +L+E + +++ ++ + L DI+ K+ +E K
Sbjct: 218 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 277
Query: 97 N-LILETQT--RDLL------MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEEN 147
N ++LET+T D L ++ LE ENL ++ ++ KKI EL EEN
Sbjct: 278 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 337
Query: 148 DTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE-SENKIGPKNICAQCK 206
TL +++ ES +L E++ + + +E L VNE + +++ + Q
Sbjct: 338 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 397
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSEL---DAGREDCKELCED 262
K ++ L D+ ++ + + R + K+ L++E+ ++C+ L +D
Sbjct: 398 TK--TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 455
Query: 263 FTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
K LE T+ E L EN+E + +K++ + +LN L ++
Sbjct: 456 LMKEKAQLE-----KTI---ETLRENSE---RQIKILEQENEHLNQTVSSLRQRSQISAE 504
Query: 323 DHI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNEC 380
+ D K++ +L TS + +I + K +++ E E+ +++ +L+
Sbjct: 505 ARVKDIEKEN--KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL 562
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
E + + +K+ +L EK A + ER + T+D K E L KE
Sbjct: 563 EKENELLQKKITNLKI-TCEKIEALEQENSELERENR-KLKKTLDSFKNLTFQLESLEKE 620
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLR 491
+L + +++ R+++ A K + Q +L + E EKE+L+
Sbjct: 621 NSQLDEENLELRRNVESLKCASMK--------MAQLQLENKELESEKEQLK 663
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 819 KRSISVISDSEVSQLKERLLSCQ---QELDDLKERYKELD-DECETCAEYLQE---RDEQ 871
K S EV +L LL C Q+ ++ ER + LD D A ++QE E
Sbjct: 35 KNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN 94
Query: 872 CARLKKEK---LSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
L+ + +S E LK + ++ ++ + + ++ + E+ LH +
Sbjct: 95 VFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHA 152
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S A+ MK E ++ +L + K+++ + E E K ++L DCK E
Sbjct: 153 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQ-------ELEEKTEQLLDCKQE 205
Query: 988 LEELKQRYKELDEE 1001
LE+++ K L +E
Sbjct: 206 LEQMEIELKRLQQE 219
>BC094764-1|AAH94764.1| 692|Homo sapiens TPR protein protein.
Length = 692
Score = 59.7 bits (138), Expect = 6e-08
Identities = 101/427 (23%), Positives = 185/427 (43%), Gaps = 32/427 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEI 436
E ++K++
Sbjct: 490 EIQVKDL 496
Score = 59.3 bits (137), Expect = 8e-08
Identities = 115/595 (19%), Positives = 239/595 (40%), Gaps = 29/595 (4%)
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN--ESKKSK 322
S++N LE + ++D G + +F+ ++ + EI++ L+ E+L+N E + +
Sbjct: 20 SVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLR 79
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTS 382
+++ + L A+ + I + + + + +L+ EK ++ + +
Sbjct: 80 LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA--EKRDLIRTN-ERLSQ 136
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ + E + LN +L E L+++ + + +V + E E KE+L +
Sbjct: 137 ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE-KELLHSQNT 195
Query: 443 KLS---KLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA 499
L+ K K D L ++ ++ + + + + E+SR + ++ K E K
Sbjct: 196 WLNTELKTKTDELLALGRE-KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH-LQKH 253
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN-LIKILSEEID 558
V E+ HNE+ + H +L+ LYKS D++ A N L + + E
Sbjct: 254 VEDLLTKLKEAKEQQASMEEKFHNELNA-HIKLSNLYKSAADDSEAKSNELTRAVEELHK 312
Query: 559 ALKIAIAKN---EEKMLSLSE-KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
LK A N ++ +L + + KD E++ I L++E L++ ND+++ K A
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE---LENANDLLSATKRKGAI 369
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
E + + K+ + E N L E +E
Sbjct: 370 LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
L+ + +E+ + + ++L++ ++E +L E K N+ ++ E R
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL-QEDTDKANKQSSVLERDNRR 488
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ VKDL + L+E A IR E+ ++
Sbjct: 489 MEIQVKDLSQQIRVL--------LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
R L +L ++ +R + S++++L+ +L S EL+ L++
Sbjct: 541 RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRK 595
Score = 50.0 bits (114), Expect = 5e-05
Identities = 138/718 (19%), Positives = 286/718 (39%), Gaps = 66/718 (9%)
Query: 385 KSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKL 444
KSV KL L ++++ + L+ + E+ S +I K+ + +E L E +
Sbjct: 19 KSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
Query: 445 SKLKIDIPRDLDQDLPA----HKKITILFDALIT-QYELSRTDYEIEKEKLRLETGTAKA 499
L++++ + L+ L A +K++ I D I Q + +RT E+E EK L
Sbjct: 76 QSLRLELEK-LNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL------- 127
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDA 559
T E E++ L E++ +L K+ E+N +++ +E+ A
Sbjct: 128 ---------------IRTNERLSQELEYLTEDVKRL-NEKLKESNTTKGELQLKLDELQA 171
Query: 560 LKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERS 619
+++ K EK L EK+ ++ LK + + L +L REK + EL+ +
Sbjct: 172 SDVSV-KYREKRLE-QEKELLHSQNTWLNTELKTKTDELLALG----REKGNEILELKCN 225
Query: 620 CQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDC 679
+ K+ L++ + EAK EQ +++E+ +
Sbjct: 226 LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAK---EQQASMEEKFHNELNAH 282
Query: 680 SRLEINIKTHEKTAEIQN----RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDY 735
+L K+ +E ++ R + L K ++E + + L E+ + ++++
Sbjct: 283 IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEM 342
Query: 736 DAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXX 795
+ LE E N L + ++E E + A V
Sbjct: 343 LEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAY 402
Query: 796 XXXXTFGDENRDLGENPKLDDSPKRSISVISDSE--VSQLKERLLSCQQELDDLKERYKE 853
T + EN +++ + + + + +E Q+ + L + ++
Sbjct: 403 VE--TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ 460
Query: 854 LDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTD 913
E + E + ++Q + L+++ +E QV +L +QIR +A+ V D
Sbjct: 461 AMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVI--RD 518
Query: 914 EDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKE 973
E+ ++ D S + ++ + IEEL+ + Q L + ++ + E+ ++
Sbjct: 519 EEVSS-----ADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Query: 974 FEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAK-IALEI-VDK 1031
+ +L+ ++ L EL+Q K + + ++QR+ L + +A+ +
Sbjct: 574 SKITELQLK-LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
Query: 1032 LSNQKVALEKQIESLSNT-------PVSNSTMYVATGSAIVQNQQITDVMKENQKLKK 1082
L + +A + S S T PV ST + +A+ Q Q+I + K+ + KK
Sbjct: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAEKK 690
Score = 47.2 bits (107), Expect = 3e-04
Identities = 100/473 (21%), Positives = 196/473 (41%), Gaps = 47/473 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
K A L+ + + A + +I K + +++ + ++ L E L E +++K
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGM-KLTELYNAYVETQDQLLLEKL--ENKRINKY 422
Query: 448 KIDIPRDLDQDLPAHKKITILFD-ALITQYELSRTDYEIEKEKLRLETGTAKA 499
+I ++++ P K+ ++ A LS + KE RL+ T KA
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>BC071583-1|AAH71583.1| 1139|Homo sapiens DCTN1 protein protein.
Length = 1139
Score = 59.7 bits (138), Expect = 6e-08
Identities = 57/245 (23%), Positives = 112/245 (45%), Gaps = 9/245 (3%)
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
D E+++ ER S QQE++ LKER EL + E ++E+ A + LE+Q
Sbjct: 176 DKEMAE--ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQN 233
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEEL 946
+ LK+ + + + K V + + N VV R + E+ + TI+EL
Sbjct: 234 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVV-RQQRERLQEELSQAESTIDEL 292
Query: 947 RYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEEC-ETC 1005
+ + + ++ +E T ++ E K +EL + +LE + + EL E ET
Sbjct: 293 K----EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETE 348
Query: 1006 AEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAI 1064
E +Q + R++EA+ +E + +++ + ++K + +N N + +++
Sbjct: 349 LELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTANLQDVNRELTNQQEASV 408
Query: 1065 VQNQQ 1069
+ QQ
Sbjct: 409 ERQQQ 413
Score = 54.8 bits (126), Expect = 2e-06
Identities = 71/301 (23%), Positives = 133/301 (44%), Gaps = 37/301 (12%)
Query: 810 ENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDD-LKERYKELDDECETCAEYLQER 868
+ KL + K I + +V + K ++ Q +L LKE KE + E Y++E
Sbjct: 107 DKAKLKELEKHKIQL---EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEM 163
Query: 869 DE-----QCARLKKEKL-----SLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWAN 918
+ + A L KE SL+Q+V LKE++ + + + A++ + A+
Sbjct: 164 ADTADAIEMATLDKEMAEERAESLQQEVEALKERV-DELTTDLEILKAEIEEKGSDGAAS 222
Query: 919 LHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
S + ++ E+N RL + +R K K+QK ME KK++E E R
Sbjct: 223 --SYQLKQLE-----EQNARLKDALVRMRDLSSSEKQEHVKLQKLME---KKNQELEVVR 272
Query: 979 KELEDCKAELEELKQRYKELDEE------CETCAEYLKQR----EEQCKRLKEAKIALEI 1028
++ E + EL + + EL E+ E E L R EE+ + L+E LE
Sbjct: 273 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
Query: 1029 VDKLSN--QKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAK 1086
++++++ Q+ A E ++E ++ + + A + + D + +K +++ A
Sbjct: 333 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAN 392
Query: 1087 L 1087
L
Sbjct: 393 L 393
Score = 48.8 bits (111), Expect = 1e-04
Identities = 59/250 (23%), Positives = 115/250 (46%), Gaps = 14/250 (5%)
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
+ D E LD + EV LKER+ +L+ LK +E + +
Sbjct: 165 DTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 224
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLK-EQIRTQQPVERQAKFADVA----VNTDEDWAN 918
L++ +EQ ARLK + + S+ K E ++ Q+ +E++ + +V E+ +
Sbjct: 225 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284
Query: 919 LHSVVVD-RMSYDAEV---EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEF 974
S + + + DA + E + L L K ++L+ TV ++ AM + + +E
Sbjct: 285 AESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLE-AMNEMNDELQE- 342
Query: 975 EAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDK-LS 1033
A+ ELE + +L+ R +E + E E + ++ K+ ++ L+ V++ L+
Sbjct: 343 NARETELE-LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTANLQDVNRELT 401
Query: 1034 NQKVA-LEKQ 1042
NQ+ A +E+Q
Sbjct: 402 NQQEASVERQ 411
Score = 47.6 bits (108), Expect = 2e-04
Identities = 52/210 (24%), Positives = 94/210 (44%), Gaps = 25/210 (11%)
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
L S +E + L+ + ++L+++ ET E + L+K K+ LEQ V K +++ Q
Sbjct: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ-VQEWKSKMQEQ 134
Query: 897 QP-VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
Q ++R+ K A R +E +R M EE+ ++
Sbjct: 135 QADLQRRLKEA-------------------RKEAKEALEAKERYM---EEMADTADAIEM 172
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
+ A E+ +E EA ++ +++ +LE LK +E + + LKQ EEQ
Sbjct: 173 ATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQ 232
Query: 1016 CKRLKEAKIALEIVDKLSNQK-VALEKQIE 1044
RLK+A + + + Q+ V L+K +E
Sbjct: 233 NARLKDALVRMRDLSSSEKQEHVKLQKLME 262
Score = 42.3 bits (95), Expect = 0.009
Identities = 54/251 (21%), Positives = 102/251 (40%), Gaps = 16/251 (6%)
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLI---KILSEEIDALKIAIAKNEEKMLS-LSEKDN 579
+V+ L E+L L + K E+ A L + KI E++ K + + + + L E
Sbjct: 89 QVRDLEEKLETL-RLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARK 147
Query: 580 KLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILM 639
+ E + EE ++ T +KE E Q ++ +D++ D+ +
Sbjct: 148 EAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEI 207
Query: 640 XXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRM 699
+ K L EQN LK+ + RD S E + H K ++ +
Sbjct: 208 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL-VRMRDLSSSE--KQEHVKLQKLMEKK 264
Query: 700 IMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLV 759
L+ Q+ ++L + +L++ + + LK DAA+ + E V LT + +
Sbjct: 265 NQELEVVRQQRERL----QEELSQAESTIDELKEQVDAAL----GAEEMVEMLTDRNLNL 316
Query: 760 EGRIAELESDI 770
E ++ EL +
Sbjct: 317 EEKVRELRETV 327
>BC016514-1|AAH16514.1| 687|Homo sapiens TPR protein protein.
Length = 687
Score = 59.7 bits (138), Expect = 6e-08
Identities = 101/427 (23%), Positives = 185/427 (43%), Gaps = 32/427 (7%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQS--LKESSNEINLKLEKLSGELF 82
NQL KN + Q I +Q T T + L ++ ++ +LE L+ ++
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVK 146
Query: 83 DIKE---QKSALEGKYQNLILETQTRDLLMS-QIKSLEMENLTKDKEIKNLTDSLKTKSK 138
+ E + + +G+ Q + E Q D+ + + K LE E + L LKTK+
Sbjct: 147 RLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTD 206
Query: 139 KINELQEE--NDTLS-NLIMENVTES-DNLNKEVDDLKKNNECLTQKCIDLEKLVNESEN 194
++ L E N+ L +EN E L ++++ LK +NE L + DL + E++
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 195 KIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGRE 254
+ Q ++E L+ LS L +S +D ++ + N++ EL +
Sbjct: 267 Q--------QASMEEKFHNELNAHIK--LSNLYKSAAD-DSEAKSNELTRAVEEL---HK 312
Query: 255 DCKELCEDFTSIKNHL---ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSE 311
KE E +I++HL E + M ++ EK+G + A ++S KR LSE
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
Query: 312 QLINNESKKSKDHIDRYKDS--LLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEK 369
+ + S + K L + +A T + E L + INKY LDEI+++
Sbjct: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKY---LDEIVKE 429
Query: 370 YTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKK 429
L E + + +ASL+ +L + L+ ++ ++ SS + D +
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
Query: 430 ENELKEI 436
E ++K++
Sbjct: 490 EIQVKDL 496
Score = 59.3 bits (137), Expect = 8e-08
Identities = 115/595 (19%), Positives = 239/595 (40%), Gaps = 29/595 (4%)
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN--ESKKSK 322
S++N LE + ++D G + +F+ ++ + EI++ L+ E+L+N E + +
Sbjct: 20 SVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLR 79
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTS 382
+++ + L A+ + I + + + + +L+ EK ++ + +
Sbjct: 80 LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA--EKRDLIRTN-ERLSQ 136
Query: 383 ELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECL 442
EL+ + E + LN +L E L+++ + + +V + E E KE+L +
Sbjct: 137 ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE-KELLHSQNT 195
Query: 443 KLS---KLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA 499
L+ K K D L ++ ++ + + + + E+SR + ++ K E K
Sbjct: 196 WLNTELKTKTDELLALGRE-KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH-LQKH 253
Query: 500 VXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN-LIKILSEEID 558
V E+ HNE+ + H +L+ LYKS D++ A N L + + E
Sbjct: 254 VEDLLTKLKEAKEQQASMEEKFHNELNA-HIKLSNLYKSAADDSEAKSNELTRAVEELHK 312
Query: 559 ALKIAIAKN---EEKMLSLSE-KDNKLTELVSTINGLKEENNSLKSLNDVITREKETQAS 614
LK A N ++ +L + + KD E++ I L++E L++ ND+++ K A
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE---LENANDLLSATKRKGAI 369
Query: 615 ELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEE 674
E + + K+ + E N L E +E
Sbjct: 370 LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429
Query: 675 KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD 734
L+ + +E+ + + ++L++ ++E +L E K N+ ++ E R
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL-QEDTDKANKQSSVLERDNRR 488
Query: 735 YDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXX 794
+ VKDL + L+E A IR E+ ++
Sbjct: 489 MEIQVKDLSQQIRVL--------LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
Query: 795 XXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE 849
R L +L ++ +R + S++++L+ +L S EL+ L++
Sbjct: 541 RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRK 595
Score = 47.2 bits (107), Expect = 3e-04
Identities = 100/473 (21%), Positives = 196/473 (41%), Gaps = 47/473 (9%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTK 122
L + + KLEK L D + + L+G+++ +E++ + + + S E L
Sbjct: 14 LNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
Query: 123 DK--------EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKN 174
+ E++ L + LK ++K EL+ D + + + L E DL +
Sbjct: 71 ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
Query: 175 NECLTQKCIDLEKLVNESENKIGPKNIC---AQCKLKENLIQSLHIGY-DNTLSKLNRSI 230
NE L+Q+ L + V K+ N Q KL E + + Y + L + +
Sbjct: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 231 SDSNT-----------------STRYNKICTLQSELDAGREDCKELCEDFTSIK---NHL 270
NT + N+I L+ L+ +E+ L E +K HL
Sbjct: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Query: 271 ELHEPNMTMDLDEKLGENNEFETK-AVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYK 329
+ H ++ L E + E K ++ + IK L++L + ++ KS + + R
Sbjct: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEAKSNE-LTRAV 307
Query: 330 DSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNE 389
+ L +L E G + + + L++ +K Q++ E+LEK +++ +L L +
Sbjct: 308 EELHKLL-KEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEKELENANDLLSATKR 365
Query: 390 KLASLNSQLIE--KENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKL 447
K A L+ + + A + +I K + +++ + ++ L E L E +++K
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGM-KLTELYNAYVETQDQLLLEKL--ENKRINKY 422
Query: 448 KIDIPRDLDQDLPAHKKITILFD-ALITQYELSRTDYEIEKEKLRLETGTAKA 499
+I ++++ P K+ ++ A LS + KE RL+ T KA
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA 475
Score = 46.0 bits (104), Expect = 8e-04
Identities = 88/469 (18%), Positives = 194/469 (41%), Gaps = 36/469 (7%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKT-AEIQNRMIMRLQKQIQ---EDDK 712
E + L+ N L ++ E T D RL +K T E+Q ++ + + +
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182
Query: 713 LFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGR---IAELESD 769
L EKE ++ T LK D L RE N++ K +E + ++ LE
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLENKKEEVSRLEEQ 239
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDE-NRDLGENPKLDDSPKRSISVISDS 828
+ +T+ + ++ + +L + KL + K S + S++
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK-SAADDSEA 298
Query: 829 EVSQLKERLLSCQQELDDLKERYKELDD---ECETCAEYLQ-ERDEQCARLKKEKLSLEQ 884
+ ++L + + L + E K + D E E + ++ E E+ RL+KE +
Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
Query: 885 QVSNLKEQ--IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLMK 941
+S K + I +++ + + A + L + Y+A VE +++ L++
Sbjct: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL------YNAYVETQDQLLLE 412
Query: 942 TIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEE 1001
+E R K L V +++ ++ +E+E +K + +LE+ + + L E+
Sbjct: 413 KLENKRINKY-LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
Query: 1002 CETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSN---STMYV 1058
+ + E +R++ +++ D +V L + E+ N + + S+ +
Sbjct: 472 TDKANKQSSVLERDNRRME-----IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 1059 ATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRENEDPS 1107
++ S ++ ++ + ++L++ N +L+ ++ G+T E E S
Sbjct: 527 SSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Score = 38.3 bits (85), Expect = 0.15
Identities = 42/184 (22%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 843 ELDDLKERYKELDDECET-CAEYLQERDEQCARLKKEKLSLEQQVSNLKEQI-RTQQPVE 900
E +L + K + ++ E A+ E D R +K K+ EQQ +++++ +Q+ +
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 901 RQAKFADVAVNTDEDWANLHSVVVDR-----MSYDAEVEKNKRLMKTIEELRYKKQDLKN 955
+ + E N + ++ ++ D + + +T EEL +K+DL
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 956 TVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQ 1015
T ++ + +E T+ K K KE K EL+ + EL + + +Y ++R EQ
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ---LKLDEL-QASDVSVKYREKRLEQ 185
Query: 1016 CKRL 1019
K L
Sbjct: 186 EKEL 189
>AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens cDNA
FLJ14957 fis, clone PLACE4000009, weakly similar to
MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B. ).
Length = 612
Score = 59.7 bits (138), Expect = 6e-08
Identities = 120/560 (21%), Positives = 238/560 (42%), Gaps = 55/560 (9%)
Query: 525 VKSLHEELTKL---YKSKVDENNANLNLIKILSE-EIDALKIAI---AKNEEKMLS---L 574
++ ELT L K +V ++ ++ +K + E+ AL+ ++ KN E + S
Sbjct: 63 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 122
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELE----RSCQVIKQNG 627
SE+D TE+ + L+EEN L+ ++ + R + + Q +L+ ++ + +K+
Sbjct: 123 SEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYE 180
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXXDE---AKSLLEQNLALKEQCEEKTRDCSRLEI 684
E+ +++ ++ +E A+ L Q ++Q EK ++ S +
Sbjct: 181 GEIRQLEEALVHVRKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 240
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE-KETKLNELTNKYEALKRDYDAAVKDL- 742
++ + E + + + +++Q++ +E T EL N+ + K + ++
Sbjct: 241 QLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQ 300
Query: 743 ----ESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXX 798
E + EA T + +G + +E ++R Q A
Sbjct: 301 RQLKEKTLEAEKSRLTAMKMQDG-MRLMEEELRDYQRAQ----------DEALTKRQLLE 349
Query: 799 XTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
T D +L L D R + + D +VSQL+ L + D L ER ++
Sbjct: 350 QTLKDLEYELEAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLTERISRSREQM 408
Query: 859 ETCA-EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWA 917
E E LQER + L+ +K+SLE+Q +LK +I + R +K + V + A
Sbjct: 409 EQLRNELLQERAAR-QDLECDKISLERQNKDLKSRIIHLEGSYRSSK-EGLVVQMEARIA 466
Query: 918 NLHSVVVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEA 976
L + A ++ N+RL + ++EL + D ++T + + K A
Sbjct: 467 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLK------A 520
Query: 977 KRKELEDCKAELEELKQRYKELDEECE---TCAEYLK-QREEQCKRLKEAKIALEIVDKL 1032
++++E+ + E++ L+ K+L E E E+L+ Q K L+ K+ +++D +
Sbjct: 521 MKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDM 580
Query: 1033 SNQKVALEKQIESLSNTPVS 1052
+ L SL PVS
Sbjct: 581 DDDD-DLSTDGGSLYEAPVS 599
Score = 54.0 bits (124), Expect = 3e-06
Identities = 75/297 (25%), Positives = 137/297 (46%), Gaps = 43/297 (14%)
Query: 816 DSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARL 875
DS KRS D E L E LL +Q+L DL + +D L++R+ + L
Sbjct: 25 DSAKRS----EDREKGALIEELLQAKQDLQDLLIAKEGRED-------LLRKRERELTAL 73
Query: 876 K---KEKLSL-EQQVSNLKEQIRTQ-----QPVERQAKFADVAV---NTDE-DWANLHSV 922
K KE++S +Q++ LKEQ + + VE K +V NT E D A
Sbjct: 74 KGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMR 133
Query: 923 VVDRMSYDAEVE-KNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE-----A 976
V + +++ +++ L + + +L+ + +DLK K ++ ++KY + ++ E
Sbjct: 134 VKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHV 193
Query: 977 KRKELEDCKA------ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD 1030
+++E E A ELE + + +E + +E LK+ EQ ++L+ K +
Sbjct: 194 RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK------N 247
Query: 1031 KLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKL 1087
++ N++ L K IE L +++ T + +QNQ K ++L +M +L
Sbjct: 248 EMENERWHLGKTIEKLQK-EMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQL 303
Score = 53.6 bits (123), Expect = 4e-06
Identities = 98/551 (17%), Positives = 219/551 (39%), Gaps = 24/551 (4%)
Query: 394 LNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPR 453
L LI KE ++LR ++ + + A+ ++ + E+ ++ + +L L+ +
Sbjct: 49 LQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE 108
Query: 454 DLDQ-DLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKA--VXXXXXXXXXX 510
++ A + T D T+ + E EK + R E + +
Sbjct: 109 ATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 168
Query: 511 XXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEK 570
+TL++ E++ L E L + K + + +A + L E++A + +++ ++
Sbjct: 169 EAKAKETLKKYEGEIRQLEEALVHVRKEEKEAVSAR----RALENELEAAQGNLSQTTQE 224
Query: 571 MLSLSEKDNKLTELVSTINGLKEE-NNSLKSLNDVITREKETQASELERSCQVIKQNGFE 629
LSEK + +E + LK E N L I + ++ A +E S + +
Sbjct: 225 QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ 284
Query: 630 LDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTH 689
LD+ K ++++ + EE+ RD R + T
Sbjct: 285 LDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALTK 344
Query: 690 EKTAEIQNRMI---MRLQKQIQED-DKLFIEKETKLNELTNKYEALKRDYDAAVKDLESS 745
+ E + + + + +++D +L + E K+++L + E + + D + + S
Sbjct: 345 RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLTERISRS 404
Query: 746 REAVNQLTTQKDLVEGRIA--ELESD-IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFG 802
RE + QL + +L++ R A +LE D I E+
Sbjct: 405 REQMEQL--RNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 462
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
+L + + ++ + ++ + + ++KE ++ E L ++ +L +
Sbjct: 463 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMK 522
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSV 922
++E +E+ RL+ K L+++ L+EQ+ + ++ Q ++ D L S
Sbjct: 523 RQVEEAEEEIDRLESSKKKLQRE---LEEQMDMNEHLQGQLN----SMKKDLRLKKLPSK 575
Query: 923 VVDRMSYDAEV 933
V+D M D ++
Sbjct: 576 VLDDMDDDDDL 586
Score = 49.2 bits (112), Expect = 8e-05
Identities = 88/426 (20%), Positives = 172/426 (40%), Gaps = 28/426 (6%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIE 716
+AK L+ L KE E+ R R +K K + M K+ Q D +L
Sbjct: 44 QAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKE-QYDAELQAL 102
Query: 717 KETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTA 776
+E+ + E T E L + + +D + V L + + ++GR ELE + Q
Sbjct: 103 RES-VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 161
Query: 777 TVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKER 836
+ + + K S +R++ ++E+ +
Sbjct: 162 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHVRKEEKEAVSARRAL----ENELEAAQGN 217
Query: 837 LLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQ 896
L QE L E+ KE ++ E E + + L K L+++++++ E RT
Sbjct: 218 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 277
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNK-RLMKTIEELRYKKQDLKN 955
+E Q + + + A + + ++ E EK++ MK + +R +++L++
Sbjct: 278 T-LELQNQLDEYKEKNRRELAEMQRQLKEKT---LEAEKSRLTAMKMQDGMRLMEEELRD 333
Query: 956 TVTKMQKAMEK-----YTKKDKEFE--AKRKELEDCKAEL-----EELKQRYKELDEE-- 1001
+A+ K T KD E+E AK L+D ++ L +++ Q EL+EE
Sbjct: 334 YQRAQDEALTKRQLLEQTLKDLEYELEAKS-HLKDDRSRLVKQMEDKVSQLEMELEEERN 392
Query: 1002 -CETCAEYLKQREEQCKRLKEAKIALEIV-DKLSNQKVALEKQIESLSNTPVSNSTMYVA 1059
+ E + + EQ ++L+ + L K++LE+Q + L + + Y +
Sbjct: 393 NSDLLTERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 452
Query: 1060 TGSAIV 1065
+ +V
Sbjct: 453 SKEGLV 458
Score = 48.4 bits (110), Expect = 1e-04
Identities = 128/648 (19%), Positives = 260/648 (40%), Gaps = 50/648 (7%)
Query: 117 MENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNE 176
ME EI++L D L +++ + D ++E + ++ +++ K+ E
Sbjct: 1 MEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEGRE 60
Query: 177 CLTQKCI-DLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNT 235
L +K +L L + ++ + KLKE YD L L S+ ++
Sbjct: 61 DLLRKRERELTALKGALKEEVSSHDQ-EMDKLKEQ--------YDAELQALRESVEEATK 111
Query: 236 STRYNKICTLQSELD-AGRE-DCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFET 293
+ + SE D AG E K L E+ ++ E E + L ++ + E
Sbjct: 112 NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ-LQRQIEDLKGDEA 170
Query: 294 KAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMD 353
KA + + + + + L E L++ K+ K+ + + +L L+A G S E
Sbjct: 171 KAKETLKKYEGEIRQLEEALVHVR-KEEKEAVSARR-ALENELEAAQGNLSQTTQE--QK 226
Query: 354 NIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKE 413
+ K + + ++ E+ +++ ++ L EKL + ++E + L +Q +
Sbjct: 227 QLSEKLKEESEQ-KEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT-STLELQNQ 284
Query: 414 RIHEISSAVTIDIVKKENELKE-ILTKECLKLSKLKI-DIPRDLDQDLPAHKKIT--ILF 469
+ E ++ + + +LKE L E +L+ +K+ D R ++++L +++ L
Sbjct: 285 -LDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQDEALT 343
Query: 470 DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH 529
+ + L +YE+E K L+ ++ V LEE N L
Sbjct: 344 KRQLLEQTLKDLEYELEA-KSHLKDDRSRLVKQMEDKVSQLEME----LEEERNNSDLLT 398
Query: 530 EELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTIN 589
E +++ + ++++ L + ++++ KI++ + + + S ++ L +
Sbjct: 399 ERISRS-REQMEQLRNELLQERAARQDLECDKISLERQNKDLKS------RIIHLEGSYR 451
Query: 590 GLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXX 649
KE L + E E + ER ++ + L++ +++M
Sbjct: 452 SSKE---GLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 508
Query: 650 XXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQE 709
D+ L + A+K Q EE + RLE + K ++ E Q M LQ Q+
Sbjct: 509 ------DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 562
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKD 757
++K+ +L +L +K D D D S EA T KD
Sbjct: 563 -----MKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKD 605
>AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein.
Length = 742
Score = 59.7 bits (138), Expect = 6e-08
Identities = 111/580 (19%), Positives = 227/580 (39%), Gaps = 30/580 (5%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + +++ L + + K +DE + + I LSEE D L +
Sbjct: 102 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCG 161
Query: 576 EKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKA 635
K TE + L E K+ + +E E + +L Q ++Q EL +++
Sbjct: 162 SPGMKRTE---SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 218
Query: 636 DILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRL-EINI-KTHEKTA 693
+ + DE +L E+ + + + E +R RL +I K +
Sbjct: 219 ENM----NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 274
Query: 694 EIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLT 753
+ N++++ + +++ + + KL+EL + LK A + D+E R+ +
Sbjct: 275 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK----AKLHDMEMERDMDRKKI 330
Query: 754 TQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPK 813
++L+E + LE + ++ + G E +L +
Sbjct: 331 --EELMEENMT-LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 387
Query: 814 L-----DDSPKRSISVISDS--EVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQ 866
L + S +++ + + V ++L ++E L ++ + L++E + LQ
Sbjct: 388 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ 447
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
L KEK LE+ + L+E Q + Q + T + +
Sbjct: 448 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEA 505
Query: 927 MSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKA 986
D E E NK L ++I+E K ++ +++K +E Y +K + E EL +
Sbjct: 506 RVKDIEKE-NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 564
Query: 987 ELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESL 1046
E E L+++ L CE ++ E + ++ K L+ L+ Q +LEK+ L
Sbjct: 565 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 624
Query: 1047 --SNTPVSNSTMYVATGSAIVQNQQI--TDVMKENQKLKK 1082
N + + + S + Q+ ++ E ++LKK
Sbjct: 625 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 664
Score = 56.4 bits (130), Expect = 5e-07
Identities = 115/542 (21%), Positives = 230/542 (42%), Gaps = 43/542 (7%)
Query: 41 QSNPIKLQDSGTITISCKMCQSLKESS---NEINLKLEKLSGELFDIKEQKSALEG-KYQ 96
Q N L D+ + + +L+E + +++ ++ + L DI+ K+ +E K
Sbjct: 218 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 277
Query: 97 N-LILETQT--RDLL------MSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEEN 147
N ++LET+T D L ++ LE ENL ++ ++ KKI EL EEN
Sbjct: 278 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 337
Query: 148 DTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNE-SENKIGPKNICAQCK 206
TL +++ ES +L E++ + + +E L VNE + +++ + Q
Sbjct: 338 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 397
Query: 207 LKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYN-KICTLQSEL---DAGREDCKELCED 262
K ++ L D+ ++ + + R + K+ L++E+ ++C+ L +D
Sbjct: 398 TK--TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 455
Query: 263 FTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK 322
K LE T+ E L EN+E + +K++ + +LN L ++
Sbjct: 456 LMKEKAQLE-----KTI---ETLRENSE---RQIKILEQENEHLNQTVSSLRQRSQISAE 504
Query: 323 DHI-DRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-LDEILEKYTKVQGDLNEC 380
+ D K++ +L TS + +I + K +++ E E+ +++ +L+
Sbjct: 505 ARVKDIEKEN--KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL 562
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKE 440
E + + +K+ +L EK A + ER + T+D K E L KE
Sbjct: 563 EKENELLQKKITNLKI-TCEKIEALEQENSELERENR-KLKKTLDSFKNLTFQLESLEKE 620
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEK--EKLRLETGTAK 498
+L + +++ R+++ A K+ L + EL +++K E L+ +
Sbjct: 621 NSQLDEENLELRRNVESLKCASMKMAQL---QLENKELESEKEQLKKGLELLKASFKKTE 677
Query: 499 AVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEID 558
+ TLE ++ +++ L EL L + + NL +KI S+ ++
Sbjct: 678 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLE 736
Query: 559 AL 560
L
Sbjct: 737 QL 738
Score = 54.4 bits (125), Expect = 2e-06
Identities = 100/586 (17%), Positives = 226/586 (38%), Gaps = 52/586 (8%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLI------KILSEEIDALKIAIAKNEEKM 571
LEE ++ +EL ++ N+NL+ ++ +E+DAL+ + ++
Sbjct: 192 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK-- 249
Query: 572 LSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELD 631
L + ++ E + I K LK N V+ K +LE + + +L
Sbjct: 250 --LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT----RARSDKLH 303
Query: 632 KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEK 691
+++ + L + + L+E+N+ L+ ++ + L ++ +
Sbjct: 304 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 363
Query: 692 TAEIQNRMIMRLQKQIQE-DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVN 750
T+E+ L ++ E ++ E + LT E L+ D+ +E + +
Sbjct: 364 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS----VEGNASKIL 419
Query: 751 QLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGE 810
++ + + ++ LE++I E+ + T
Sbjct: 420 KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET---------- 469
Query: 811 NPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKE-RYKELDDECETCAEYLQERD 869
L ++ +R I ++ + E L + + S +Q E R K+++ E + E ++E
Sbjct: 470 ---LRENSERQIKIL-EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 525
Query: 870 EQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSY 929
+ ++++ EK +++++ + KE+ + +E + LH + +
Sbjct: 526 SKLSKIEFEKRQIKKELEHYKEKGERAEELENE----------------LHHLEKENELL 569
Query: 930 DAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
++ K + IE L + +L+ K++K ++ + + E+ KE E
Sbjct: 570 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 629
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNT 1049
EL++ + L A+ + +E ++ K LE++ + LE + L
Sbjct: 630 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 689
Query: 1050 PVSNSTMYVATGSAIVQ-NQQITDVMKENQKLKKMNAKLITICKKR 1094
+ I Q ++ D+ ENQ L+K N + + I KR
Sbjct: 690 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQK-NLEELKISSKR 734
Score = 37.5 bits (83), Expect = 0.26
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 21/167 (12%)
Query: 53 ITISCKMCQSLKESSNEI---NLKLEKLSGELFDIKEQKSALEGKY-----QNLILETQT 104
+ I+C+ ++L++ ++E+ N KL+K ++ Q +LE + +NL L
Sbjct: 576 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 635
Query: 105 RDLLMSQIK--SLEMEN--LTKDKE-IKNLTDSLKTKSKKINELQE-------ENDTLSN 152
L + +K L++EN L +KE +K + LK KK L+ EN L
Sbjct: 636 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 695
Query: 153 LIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPK 199
+ + + L E+ DL+ N+ L QK ++ K+ ++ ++G +
Sbjct: 696 TLENSNKKIQQLESELQDLEMENQTL-QKNLEELKISSKRLEQLGKR 741
Score = 35.5 bits (78), Expect = 1.1
Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 819 KRSISVISDSEVSQLKERLLSCQ---QELDDLKERYKELD-DECETCAEYLQE---RDEQ 871
K S EV +L LL C Q+ ++ ER + LD D A ++QE E
Sbjct: 35 KNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQEN 94
Query: 872 CARLKKEK---LSLEQQVSNLKEQ-IRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRM 927
L+ + +S E LK + ++ ++ + + ++ + E+ LH +
Sbjct: 95 VFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHA 152
Query: 928 SYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAE 987
S A+ MK E ++ +L + K+++ + E E K ++L DCK E
Sbjct: 153 SSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQ-------ELEEKTEQLLDCKQE 205
Query: 988 LEELKQRYKELDEE 1001
LE+++ K L +E
Sbjct: 206 LEQMEIELKRLQQE 219
>AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein.
Length = 1642
Score = 59.7 bits (138), Expect = 6e-08
Identities = 177/921 (19%), Positives = 369/921 (40%), Gaps = 82/921 (8%)
Query: 110 SQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVD 169
SQ ++ + L + ++N T S S + LQ + L++ + + E D+L ++
Sbjct: 247 SQKLQIQFQQLQASETLRNSTHS----STAADLLQAKQQILTH--QQQLEEQDHL---LE 297
Query: 170 DLKKNNECLTQKCIDLEKLVN----ESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSK 225
D +K E T + L++ + E + K+ N + + KE +I+ L+ + +
Sbjct: 298 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNT---KIIEE 353
Query: 226 LNRSISDSNTSTRYNKIC-TLQSELDAGREDCKELCEDFTSIKN--HLELHEPNMTMDLD 282
+++ + T +K+ LQ ++ ++ K + + T+ K E M
Sbjct: 354 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTV 413
Query: 283 EKLGENN----EFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLAVLD 337
E+L + N +FET V+ M E +R L L +L + I + K L+
Sbjct: 414 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL----DEMYGQQIVQMKQELIRQHM 469
Query: 338 AEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNS 396
A+ + M+N + Y I ++E K V +NE +L+ N + L
Sbjct: 470 AQMEEMKTR-HKGEMENALRSYSNITVNEDQIKLMNVA--INELNIKLQDTNSQKEKLKE 526
Query: 397 QL-IEKENACNILRIQKERIHEIS-SAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
+L + E C + R ++ + E+S S I ++ +E E K D+ +
Sbjct: 527 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 586
Query: 455 LDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXX 514
+ + K++ + +A +T Y++ +EKEK + A++
Sbjct: 587 IVSASESRKELELKHEAEVTNYKIKLE--MLEKEKNAVLDRMAESQEAELERLRT----- 639
Query: 515 FDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSL 574
L E+ L E+L ++ +++ NL + ++ID L+ +++ E M
Sbjct: 640 -QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH--YKQQIDGLQNEMSQKIETMQF- 695
Query: 575 SEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMK 634
EKDN +T+ I + + + +SL + + E Q +EL++ ++++Q E ++
Sbjct: 696 -EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 754
Query: 635 ADI----LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKT-RDCSRLEINIKTH 689
++ L ++ L +N LK+ E+KT D ++ +
Sbjct: 755 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIHTPVSQE 812
Query: 690 EKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNE----LTNKYEALKRDYDAAVKDLESS 745
E+ + + +++ ++ IE+ L + L + E + + A K+ E +
Sbjct: 813 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 872
Query: 746 REAVNQ----LTTQKDLVEGRIAELESDIRTEQTAT---VXXXXXXXXXXXXXXXXXXXX 798
+ + + L KD +E + E + +++ A +
Sbjct: 873 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 932
Query: 799 XTFGDENRDLGENPKLDDS---PKRSISVISDSEVSQ----LKERLLSCQQELDDLKERY 851
TF E ++GE + D + K ++ E+SQ L E+L E+ L E
Sbjct: 933 KTFVAETLEMGEVXEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKPKPGEISFLNEEV 992
Query: 852 KELDDECETCAEYLQERDEQCARLKKEKL-SLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
K L E E + +E + + E + S + QVS+L + + T + + V
Sbjct: 993 KSLKPEKEPVSLRCRELEIIINHNRAENVXSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1052
Query: 911 NTDEDWANLHSVVVDRMSYDAEV--EKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYT 968
+ E+ +V D++S++ E++K+ ++ L ++ T+ +
Sbjct: 1053 SFGEE---SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ----PSEND 1105
Query: 969 KKDKEFEAKRKELEDCKAELE 989
K KE + E D + ++E
Sbjct: 1106 KLQKELNVLKSEQNDLRLQME 1126
Score = 58.0 bits (134), Expect = 2e-07
Identities = 113/585 (19%), Positives = 247/585 (42%), Gaps = 48/585 (8%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEE--IDALKIAIAKNEEKMLSLSEKDNKLTEL 584
S +E K+Y+ + D+ N N +I +E I+ L I + E+K L L +K +L
Sbjct: 311 SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL 370
Query: 585 VSTING-LKEENNSLKSLNDVIT--REKETQASE----LERSCQVIKQNGFELDKMKADI 637
+ + + ++N +K++ +T ++KE Q+SE L + + +++ + + + DI
Sbjct: 371 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 430
Query: 638 LMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQN 697
+ E + Q + +Q E + +++E +KT K E++N
Sbjct: 431 VQRMEQETQRKLEQLRA--ELDEMYGQQIVQMKQ-ELIRQHMAQME-EMKTRHK-GEMEN 485
Query: 698 RMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQ-K 756
+ + ED + +NEL K + + ++L E L Q +
Sbjct: 486 ALRSYSNITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 543
Query: 757 DLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDD 816
DLVE E R QT DL
Sbjct: 544 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV------------EDLKAEIVSAS 591
Query: 817 SPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDD-ECETC-AEYLQERDEQCAR 874
++ + + ++EV+ K +L ++E + + +R E + E E + L +E+ ++
Sbjct: 592 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 651
Query: 875 LKKEKLSLEQQVS--NLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
LK E L +E +++ LK+ + + +++ + +++ + E
Sbjct: 652 LK-EDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 710
Query: 933 VEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELK 992
+ K K L +++ + K +++ + ++QK +E +++KE +E+++ + + E L+
Sbjct: 711 ISKLKDLQQSL--VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 768
Query: 993 QRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVS 1052
++ KE + + + E Q E + LK+ K LE + K+ + V+ E+++ L +
Sbjct: 769 KQMKEKENDLQ---EKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQEERLIFLDSIKSK 824
Query: 1053 NSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKT 1097
+ V ++I +++EN+ LK+ +L +K+ T
Sbjct: 825 SKDS--------VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 861
Score = 52.4 bits (120), Expect = 9e-06
Identities = 104/461 (22%), Positives = 203/461 (44%), Gaps = 61/461 (13%)
Query: 47 LQDSGTITISCKMCQSLKESSNEINLKL-------EKLSGELFDIKEQKSALEGKYQNLI 99
L+ IT++ + + + NE+N+KL EKL EL I E+K AL+ + ++L+
Sbjct: 487 LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLV 546
Query: 100 LETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENVT 159
+L S+ ++I+ ++ + K+NE + T+ +L E V+
Sbjct: 547 -----EELSFSR------------EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 589
Query: 160 ESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSLHIGY 219
S++ KE+ +LK E K I LE L E +N + + +Q E L L +
Sbjct: 590 ASES-RKEL-ELKHEAEVTNYK-IKLEMLEKE-KNAVLDRMAESQEAELERLRTQLLFSH 645
Query: 220 DNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTM 279
+ LSKL D R N I L+ L K ++ + M+
Sbjct: 646 EEELSKLK---EDLEIEHRIN-IEKLKDNLG-------------IHYKQQIDGLQNEMSQ 688
Query: 280 DLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKD--SLLAVLD 337
++ E + TK +++ EI + L L + L+N++S++ I+ + +L +
Sbjct: 689 KIETMQFEKDNLITKQNQLILEISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEE 747
Query: 338 AEFGTTSLDVFEI-LMDNIINKYQIDLD-EILEKYTKVQGDLNECTSELKSVNEKLASLN 395
E GT +V E+ L ++ K + + ++ EK+ +++ + N + K E + ++
Sbjct: 748 KEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE-NSILKDEKKTLEDMLKIH 806
Query: 396 SQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDL 455
+ + ++E + I K + + I+I+ +EN E L ++C++L++ +I +
Sbjct: 807 TPVSQEERLIFLDSI-KSKSKDSVWEKEIEILIEEN---EDLKQQCIQLNE---EIEKQR 859
Query: 456 DQDLPAHKKITILFDALITQYEL---SRTDYEIEKEKLRLE 493
+ A K + + L +Y + D E K K LE
Sbjct: 860 NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELE 900
Score = 52.4 bits (120), Expect = 9e-06
Identities = 166/782 (21%), Positives = 327/782 (41%), Gaps = 86/782 (10%)
Query: 24 RNQLDGAKSKNDNIIET----QSNPIKLQDSGTITISC--KMCQSLKES-SNEINLKLEK 76
+ Q+DG +++ IET + N I Q+ + IS + QSL S S E+ L++ +
Sbjct: 676 KQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 735
Query: 77 LSGELFDIKEQ---KSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSL 133
L E+ ++++ K LE + Q L L+T+ LL Q+K E + K +++ L
Sbjct: 736 LQKEIEILRQEEKEKGTLEQEVQELQLKTE---LLEKQMKEKENDLQEKFAQLEAENSIL 792
Query: 134 KTKSKKINELQEENDTLSN----LIMENVTES--DNL-NKEVDDLKKNNECLTQKCIDLE 186
K + K + ++ + + +S + ++++ D++ KE++ L + NE L Q+CI L
Sbjct: 793 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 852
Query: 187 KLVNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQ 246
+ + + N A+ + N Q L Y L K+ + DS +
Sbjct: 853 EEIEKQRNTFS----FAEKNFEVN-YQELQEEY-ACLLKVKDDLEDSKNKQELE----YK 902
Query: 247 SELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDE-KLGENNEFETKAVKVMSEI-KR 304
S+L A E+ + T++K + + + T + ++GE E +T + E+ KR
Sbjct: 903 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVXEKDTTELMEKLEVTKR 962
Query: 305 NLNSLSEQLIN-NESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDL 363
LS++L + +E K K + + + L E SL E ++ IIN +
Sbjct: 963 EKLELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRCRE--LEIIINHNR--A 1018
Query: 364 DEILEKYTKVQGDLNECTS--------ELKSVNEKLASLNSQLIEKENACNILRIQKERI 415
+ + T+V L+ + + VN+ + ++E + + + + +E
Sbjct: 1019 ENVXSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1078
Query: 416 HEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALI-- 473
E + V KE+ L+ E KL K ++++ + DL + + +L+
Sbjct: 1079 QEQLILDHLPSVTKESSLRATQPSENDKLQK-ELNVLKSEQNDLRLQMEAQRICLSLVYS 1137
Query: 474 TQYELSRTDYEIEKEK----LRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLH 529
T + R E EK+K L+ E A+ +E +E K LH
Sbjct: 1138 THVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1197
Query: 530 EELTKLYKSKVDENNANL-NLIKILSE-EIDALKIAIAKNEEKMLSLSEKDNKLTELVST 587
+ KL K+ +E + L L +L E ALK + +++ +N+ EL
Sbjct: 1198 LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1257
Query: 588 INGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXX 647
+++ ++ +L + +T E L ++ K G + D MK +
Sbjct: 1258 RYEVQDFQENMHTLLNKVTEEYN---KLLVLQTRLSKIWGQQTDGMKLEF---------G 1305
Query: 648 XXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQI 707
E S+ Q L++ +++N K+ K + +Q+ +L++Q+
Sbjct: 1306 EENLPKEETEFLSIHSQMTNLED-----------IDVNHKS--KLSSLQDLEKTKLEEQV 1352
Query: 708 QEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELE 767
Q E E+ ++ L + + +++Y+A + L+ +AV++ T L + E
Sbjct: 1353 Q-------ELESLISSLXQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITE 1405
Query: 768 SD 769
SD
Sbjct: 1406 SD 1407
Score = 46.8 bits (106), Expect = 4e-04
Identities = 108/523 (20%), Positives = 224/523 (42%), Gaps = 57/523 (10%)
Query: 516 DTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+ + + + E+K++ ELT K K +++ + + EE+ ++ E ++
Sbjct: 376 EQIVQKNQEIKNMKLELTNS-KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 434
Query: 576 EKDN--KLTELVSTINGL--------KEE--NNSLKSLNDVITREKETQASELERSCQVI 623
E++ KL +L + ++ + K+E + + ++ TR K + L RS I
Sbjct: 435 EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL-RSYSNI 493
Query: 624 KQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE 683
N ++ M I +E +LE+ AL+ Q E+ + S
Sbjct: 494 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR 553
Query: 684 INIKTHEKTAEIQNRMIMRLQKQIQ--EDDKLFI------EKETKLN---ELTN---KYE 729
I+ +T Q + K + ED K I KE +L E+TN K E
Sbjct: 554 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 613
Query: 730 ALKRDYDAAVKDLESSREA-VNQLTTQKDLV-EGRIAELESDIRTEQTATVXXXXXXXXX 787
L+++ +A + + S+EA + +L TQ E +++L+ D+ E +
Sbjct: 614 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 673
Query: 788 XXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDL 847
+ + + K + K++ ++ S++ L++ L++ + E ++
Sbjct: 674 HYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE--EM 729
Query: 848 KERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFAD 907
+ EL E E L++ +++ L++E L+ + L++Q++ ++ + Q KFA
Sbjct: 730 TLQINELQKEIEI----LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-DLQEKFAQ 784
Query: 908 VAVN---------TDEDWANLHSVVV--DRMSY-DAEVEKNKRLM--KTIEELRYKKQDL 953
+ T ED +H+ V +R+ + D+ K+K + K IE L + +DL
Sbjct: 785 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 844
Query: 954 KNTVTKMQKAMEK----YTKKDKEFEAKRKELEDCKAELEELK 992
K ++ + +EK ++ +K FE +EL++ A L ++K
Sbjct: 845 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVK 887
Score = 44.0 bits (99), Expect = 0.003
Identities = 89/420 (21%), Positives = 180/420 (42%), Gaps = 50/420 (11%)
Query: 657 EAKSLLEQNLALKEQCEEKTRDCSRLE----INIKTHEKTAE--IQ-NRMIMRLQKQIQE 709
E + + L L EQ ++ +L+ + TH TA +Q + I+ Q+Q++E
Sbjct: 232 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 291
Query: 710 DDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAELESD 769
D L + + K + T + L+ V ++E ++ N + E I EL +
Sbjct: 292 QDHLLEDYQKKKEDFTMQISFLQEKIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTK 349
Query: 770 IRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSE 829
I E+ T+ +N+++ +N KL+ + + S E
Sbjct: 350 IIEEEKKTLELKDKLTTADKLLGELQEQIV---QKNQEI-KNMKLELTNSKQKERQSSEE 405
Query: 830 VSQL--------KERLLSCQQELDDLKERYKELDDECETCAEYLQER-DEQCARLKKEKL 880
+ QL K Q E D ++ +E + E L E +Q ++K+E +
Sbjct: 406 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 465
Query: 881 SLEQQVSNLKE-QIRTQQPVERQAK-FADVAVNTDEDWANLHSVVVDRMSY---DAEVEK 935
Q ++ ++E + R + +E + ++++ VN ED L +V ++ ++ D +K
Sbjct: 466 --RQHMAQMEEMKTRHKGEMENALRSYSNITVN--EDQIKLMNVAINELNIKLQDTNSQK 521
Query: 936 NK---RLMKTIEE---LRYKKQDLKNTVT----KMQKAMEKYTKKDKEFEAKRKEL---E 982
K L +EE L+ + +DL ++ ++Q+A + +++ + K L E
Sbjct: 522 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 581
Query: 983 DCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS-NQKVALEK 1041
D KAE+ + KEL+ + E K + E ++ K A ++D+++ +Q+ LE+
Sbjct: 582 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA-----VLDRMAESQEAELER 636
Score = 37.5 bits (83), Expect = 0.26
Identities = 47/221 (21%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 842 QELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVE- 900
Q+L + + K+ D LQ+ + +E L L +Q L+ Q + Q E
Sbjct: 203 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 262
Query: 901 -RQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTK 959
R + + A A+L +++ ++E+ L +E+ + KK+D ++
Sbjct: 263 LRNSTHSSTA-------ADLLQAKQQILTHQQQLEEQDHL---LEDYQKKKEDFTMQISF 312
Query: 960 MQKAMEKY-TKKDKEFEAKRKE--------LEDCKAELEELKQRYKELDEECETCAEYLK 1010
+Q+ ++ Y ++DK+ E KE +E+ ++ E +++ EL ++ T + L
Sbjct: 313 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 372
Query: 1011 QREEQ-CKRLKEAK-IALEIVDKLSNQKVALEKQIESLSNT 1049
+ +EQ ++ +E K + LE+ + ++ + E +I+ L T
Sbjct: 373 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSE-EIKQLMGT 412
>X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain ( 544
AA) protein.
Length = 543
Score = 59.3 bits (137), Expect = 8e-08
Identities = 104/522 (19%), Positives = 211/522 (40%), Gaps = 41/522 (7%)
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
K++ N K L + + +E+Q SELE S + + EL K+K
Sbjct: 52 KKQRNFDKILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 110
Query: 652 XXXXDEAKSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+E L EQ + + E K + ++E+ E A +++ L+ Q
Sbjct: 111 KNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQ 170
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL 766
+ E +++ E E KL E + E KR++ V L++S +A + + V+ + +
Sbjct: 171 L-EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK---M 226
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
E D+ + + D L + + +D K +I+++
Sbjct: 227 EGDLNEME---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV- 282
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+ + L+ L + ++ + K D E +E +Q Q L +K ++ +
Sbjct: 283 ERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADL 342
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEE 945
S L+ ++ ++ V+ + A D A + + A +E+ K+ M+ TI++
Sbjct: 343 SQLQTEV--EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 400
Query: 946 LRYKKQD-----LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
L+++ + LK ++QK + + + E EA++K + + + ++R KEL
Sbjct: 401 LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL-- 458
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVAT 1060
Q EE K L + ++VDKL + A ++Q E +N + +
Sbjct: 459 --------TYQTEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKV 507
Query: 1061 GSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
+ + ++ D+ + ++ K+ AK I G G N E
Sbjct: 508 QHELDEAEERADIAE--SQVNKLRAKSRDI----GTKGLNEE 543
Score = 39.5 bits (88), Expect = 0.065
Identities = 87/448 (19%), Positives = 192/448 (42%), Gaps = 36/448 (8%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDI 84
+ L+ K + N IE ++ ++ + K ++ + E K E+ EL
Sbjct: 20 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWKQKYEESQSELESS 78
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
+++ +L + L + + +++ + EN +EI +LT+ L + K I+EL+
Sbjct: 79 QKEARSLSTELFKL---KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 135
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQ 204
+ L E + L + L+ + + ++ ++ E E K+ K+
Sbjct: 136 KVRKQLE---AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD---- 188
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
E + Q+ + + L S+ D+ T +R N+ ++ +++ D E+ E
Sbjct: 189 ----EEMEQAKR-NHLRVVDSLQTSL-DAETRSR-NEALRVKKKMEG---DLNEM-EIQL 237
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ--LINNESKKSK 322
S N + L L + AV+ ++K N+ + + L+ E ++ +
Sbjct: 238 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 297
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--IIN-KYQIDLDEILEKYTKVQGDLNE 379
+++ + S + D E TS V + N +IN K ++D D + + T+V+ + E
Sbjct: 298 AVVEQTERS-RKLADRELIETSERVQLLHSQNTSLINQKKKMDAD-LSQLQTEVEEAVQE 355
Query: 380 CTSELKSVNEKL--ASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEIL 437
C + + + + A++ ++ ++KE + ER+ + D+ + +E ++I
Sbjct: 356 CRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAEQIA 412
Query: 438 TKECLK-LSKLKIDIPRDLDQDLPAHKK 464
K K L KL+ + R+L+ +L A +K
Sbjct: 413 LKGGKKQLQKLEARV-RELENELEAEQK 439
>M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac myosin
heavy chain mRNA, 3' end. ).
Length = 543
Score = 59.3 bits (137), Expect = 8e-08
Identities = 104/522 (19%), Positives = 211/522 (40%), Gaps = 41/522 (7%)
Query: 592 KEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXX 651
K++ N K L + + +E+Q SELE S + + EL K+K
Sbjct: 52 KKQRNFDKILAEWKQKYEESQ-SELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 110
Query: 652 XXXXDEAKSLLEQNLALKEQCEE-----KTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQ 706
+E L EQ + + E K + ++E+ E A +++ L+ Q
Sbjct: 111 KNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQ 170
Query: 707 IQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIAEL 766
+ E +++ E E KL E + E KR++ V L++S +A + + V+ + +
Sbjct: 171 L-EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK---M 226
Query: 767 ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVIS 826
E D+ + + D L + + +D K +I+++
Sbjct: 227 EGDLNEME---IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV- 282
Query: 827 DSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQV 886
+ + L+ L + ++ + K D E +E +Q Q L +K ++ +
Sbjct: 283 ERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADL 342
Query: 887 SNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMK-TIEE 945
S L+ ++ ++ V+ + A D A + + A +E+ K+ M+ TI++
Sbjct: 343 SQLQTEV--EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 400
Query: 946 LRYKKQD-----LKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDE 1000
L+++ + LK ++QK + + + E EA++K + + + ++R KEL
Sbjct: 401 LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL-- 458
Query: 1001 ECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIESLSNTPVSNSTMYVAT 1060
Q EE K L + ++VDKL + A ++Q E +N + +
Sbjct: 459 --------TYQTEEDRKNLLRLQ---DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKV 507
Query: 1061 GSAIVQNQQITDVMKENQKLKKMNAKLITICKKRGKTGANRE 1102
+ + ++ D+ + ++ K+ AK I G G N E
Sbjct: 508 QHELDEAEERADIAE--SQVNKLRAKSRDI----GTKGLNEE 543
Score = 39.5 bits (88), Expect = 0.065
Identities = 87/448 (19%), Positives = 192/448 (42%), Gaps = 36/448 (8%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDI 84
+ L+ K + N IE ++ ++ + K ++ + E K E+ EL
Sbjct: 20 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWKQKYEESQSELESS 78
Query: 85 KEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQ 144
+++ +L + L + + +++ + EN +EI +LT+ L + K I+EL+
Sbjct: 79 QKEARSLSTELFKL---KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 135
Query: 145 EENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQ 204
+ L E + L + L+ + + ++ ++ E E K+ K+
Sbjct: 136 KVRKQLE---AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD---- 188
Query: 205 CKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFT 264
E + Q+ + + L S+ D+ T +R N+ ++ +++ D E+ E
Sbjct: 189 ----EEMEQAKR-NHLRVVDSLQTSL-DAETRSR-NEALRVKKKMEG---DLNEM-EIQL 237
Query: 265 SIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ--LINNESKKSK 322
S N + L L + AV+ ++K N+ + + L+ E ++ +
Sbjct: 238 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 297
Query: 323 DHIDRYKDSLLAVLDAEFGTTSLDVFEILMDN--IIN-KYQIDLDEILEKYTKVQGDLNE 379
+++ + S + D E TS V + N +IN K ++D D + + T+V+ + E
Sbjct: 298 AVVEQTERS-RKLADRELIETSERVQLLHSQNTSLINQKKKMDAD-LSQLQTEVEEAVQE 355
Query: 380 CTSELKSVNEKL--ASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEIL 437
C + + + + A++ ++ ++KE + ER+ + D+ + +E ++I
Sbjct: 356 CRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAEQIA 412
Query: 438 TKECLK-LSKLKIDIPRDLDQDLPAHKK 464
K K L KL+ + R+L+ +L A +K
Sbjct: 413 LKGGKKQLQKLEARV-RELENELEAEQK 439
>X03541-1|CAA27243.1| 641|Homo sapiens protein ( Human mRNA of trk
oncogene. ).
Length = 641
Score = 58.8 bits (136), Expect = 1e-07
Identities = 55/247 (22%), Positives = 110/247 (44%), Gaps = 16/247 (6%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
+ +K ++ QQ+ DD +ER + L E E ++ + + A L + +E+++
Sbjct: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
Query: 890 KEQIRTQ-QPVERQAKFAD-------VAVN---TDEDWANLHSVVVDRMSYDAEVEKNKR 938
+E++ T Q +E K AD V N DE+ L + ++ + AE E +++
Sbjct: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLEEAKHIAE-EADRK 125
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ +L + DL+ T + + A + + D++ + L+ A E+ Q+ +
Sbjct: 126 YEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKY 185
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEKQIESLSNTPVSNSTMY 1057
+EE + + LK+ E + + + + LE +D L + +E TP S
Sbjct: 186 EEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDTNSTSGDPVEKKDETPFGVS--- 242
Query: 1058 VATGSAI 1064
VA G A+
Sbjct: 243 VAVGLAV 249
Score = 40.3 bits (90), Expect = 0.037
Identities = 44/191 (23%), Positives = 90/191 (47%), Gaps = 16/191 (8%)
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
D+ + E + + +R +++EV+ L R+ ++ELD +ER T
Sbjct: 22 DDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER-------LATAL 74
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAK-FADVAVNTDEDWANLHS 921
+ L+E ++ ++ +E + +E++ Q+ +AK A+ A E+ A
Sbjct: 75 QKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLEEAKHIAEEADRKYEEVARKLV 134
Query: 922 VV---VDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
++ ++R AE+ ++ R + E++R Q+LK + A EKY++K+ ++E +
Sbjct: 135 IIEGDLERTEERAELAES-RCREMDEQIRLMDQNLK----CLSAAEEKYSQKEDKYEEEI 189
Query: 979 KELEDCKAELE 989
K L D E E
Sbjct: 190 KILTDKLKEAE 200
>L12579-1|AAA35654.1| 678|Homo sapiens protein ( Human alternatively
spliced CUTL1 mRNA, complete cds. ).
Length = 678
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/264 (24%), Positives = 125/264 (47%), Gaps = 27/264 (10%)
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT-Q 896
L Q+L +R +++ E + E L+E +++ A +K ++++++ LKE+IR +
Sbjct: 106 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA----LKEKIREYE 161
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
Q ++ QA+ +A+ ++ N +R + ++ +L EE +K Q L+
Sbjct: 162 QTLKNQAE--TIALEKEQKLQN-DFAEKERKLQETQMSTTSKL----EEAEHKVQSLQTA 214
Query: 957 VTKMQKAM-EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK----- 1010
+ K + + + TK D+E AK E+E +LE QR + E ET E L
Sbjct: 215 LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHS 274
Query: 1011 -QREEQCKRLKEAKIALEIVDK--LSNQKVALEKQI----ESLSNTPVSNSTMYVATGSA 1063
Q Q ++ + + A+E++ + L + A E++I E + S + + + S
Sbjct: 275 LQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQ 334
Query: 1064 IVQNQQITDVMKENQKLKKMNAKL 1087
I Q +Q + +N LK++ KL
Sbjct: 335 ISQLEQ--QLSAKNSTLKQLEEKL 356
Score = 43.2 bits (97), Expect = 0.005
Identities = 85/402 (21%), Positives = 163/402 (40%), Gaps = 43/402 (10%)
Query: 318 SKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-----LDEILEKYTK 372
SK+SK+ + + ++D +LD+ + L + + I+ L E LE+Y K
Sbjct: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
++ +K++ EK+ L +N + ++KE+ + D +KE +
Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTL---KNQAETIALEKEQ------KLQNDFAEKERK 189
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDY--EIEKEKL 490
L+E KL + + + + L L K T LFD L T+Y+ T EIE
Sbjct: 190 LQETQMSTTSKLEEAEHKV-QSLQTAL--EKTRTELFD-LKTKYDEETTAKADEIEMIMT 245
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
LE +A +TL E + + +++ K+ E +
Sbjct: 246 DLERANQRAEVAQREA---------ETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTR 296
Query: 551 KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE-LVSTINGLKEE----NNSLKSLNDVI 605
L E+ A + IA+ E + L KL E S I+ L+++ N++LK L + +
Sbjct: 297 SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKL 356
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
+ + + E+++ ++K F + ++ +SL +N
Sbjct: 357 KGQADYE--EVKKELNILKSMEFAPSE-------GAGTQDAAKPLEVLLLEKNRSLQSEN 407
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQI 707
AL+ + + C+ L++ I TA Q +I RL++ +
Sbjct: 408 AALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL 449
Score = 37.9 bits (84), Expect = 0.20
Identities = 49/248 (19%), Positives = 117/248 (47%), Gaps = 26/248 (10%)
Query: 813 KLDDSPKRSISVISDSE--VSQLKERLLSCQQELDDLKERYKE----LDDECETCAEYLQ 866
KL ++ + S + ++E V L+ L + EL DLK +Y E DE E L+
Sbjct: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
+++ ++E +L +Q+S+ ++ +++ A + A+ V+ R
Sbjct: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQK-APDVEQAIE-----------VLTR 296
Query: 927 MSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTKM-QKAMEKYTKKDKEFEAKRKELEDC 984
S + E+ K + + + +E++ Q L+ ++TK+ + + + ++ +++ AK L+
Sbjct: 297 SSLEVELAAKEREIAQLVEDV----QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 352
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+ +L+ + Y+E+ +E + ++ + ++A LE++ N+ + E
Sbjct: 353 EEKLKG-QADYEEVKKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410
Query: 1045 SLSNTPVS 1052
+SN+ +S
Sbjct: 411 RISNSDLS 418
>BC066592-1|AAH66592.1| 1516|Homo sapiens CUTL1 protein protein.
Length = 1516
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/264 (24%), Positives = 125/264 (47%), Gaps = 27/264 (10%)
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT-Q 896
L Q+L +R +++ E + E L+E +++ A +K ++++++ LKE+IR +
Sbjct: 106 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA----LKEKIREYE 161
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
Q ++ QA+ +A+ ++ N +R + ++ +L EE +K Q L+
Sbjct: 162 QTLKNQAE--TIALEKEQKLQN-DFAEKERKLQETQMSTTSKL----EEAEHKVQSLQTA 214
Query: 957 VTKMQKAM-EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK----- 1010
+ K + + + TK D+E AK E+E +LE QR + E ET E L
Sbjct: 215 LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHS 274
Query: 1011 -QREEQCKRLKEAKIALEIVDK--LSNQKVALEKQI----ESLSNTPVSNSTMYVATGSA 1063
Q Q ++ + + A+E++ + L + A E++I E + S + + + S
Sbjct: 275 LQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQ 334
Query: 1064 IVQNQQITDVMKENQKLKKMNAKL 1087
I Q +Q + +N LK++ KL
Sbjct: 335 ISQLEQ--QLSAKNSTLKQLEEKL 356
Score = 39.5 bits (88), Expect = 0.065
Identities = 50/250 (20%), Positives = 118/250 (47%), Gaps = 26/250 (10%)
Query: 813 KLDDSPKRSISVISDSE--VSQLKERLLSCQQELDDLKERYKE----LDDECETCAEYLQ 866
KL ++ + S + ++E V L+ L + EL DLK +Y E DE E L+
Sbjct: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
+++ ++E +L +Q+S+ ++ +++ A + A+ V+ R
Sbjct: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQK-APDVEQAIE-----------VLTR 296
Query: 927 MSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTKM-QKAMEKYTKKDKEFEAKRKELEDC 984
S + E+ K + + + +E++ Q L+ ++TK+ + + + ++ +++ AK L+
Sbjct: 297 SSLEVELAAKEREIAQLVEDV----QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 352
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+ +L+ + Y+E+ +E + ++ + ++A LE++ N+ + E
Sbjct: 353 EEKLKG-QADYEEVKKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410
Query: 1045 SLSNTPVSNS 1054
+SN+ +S S
Sbjct: 411 RISNSDLSGS 420
Score = 35.9 bits (79), Expect = 0.80
Identities = 66/290 (22%), Positives = 123/290 (42%), Gaps = 26/290 (8%)
Query: 318 SKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-----LDEILEKYTK 372
SK+SK+ + + ++D +LD+ + L + + I+ L E LE+Y K
Sbjct: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
++ +K++ EK+ L +N + ++KE+ + D +KE +
Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTL---KNQAETIALEKEQ------KLQNDFAEKERK 189
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDY--EIEKEKL 490
L+E KL + + + + L L K T LFD L T+Y+ T EIE
Sbjct: 190 LQETQMSTTSKLEEAEHKV-QSLQTAL--EKTRTELFD-LKTKYDEETTAKADEIEMIMT 245
Query: 491 RLETGT--AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS--LHEELTKLYKSKVD-ENNA 545
LE A+ +L+ A K+ + + + L +S ++ E A
Sbjct: 246 DLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAA 305
Query: 546 NLNLIKILSEEIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTINGLKEE 594
I L E++ L+ ++ K E S +S+ + +L+ ST+ L+E+
Sbjct: 306 KEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 355
>BC050058-1|AAH50058.1| 703|Homo sapiens Unknown (protein for
MGC:51241) protein.
Length = 703
Score = 58.8 bits (136), Expect = 1e-07
Identities = 94/425 (22%), Positives = 190/425 (44%), Gaps = 37/425 (8%)
Query: 39 ETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNL 98
ET S P+ + + C +S S +E L L L+ ++ ++E + + Q
Sbjct: 256 ETPSRPLSSTSNPFKSSKCSTARSSPNSVSE--LSLASLTEKIQKMEENHHSTAEELQAT 313
Query: 99 ILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIMENV 158
+ E + ++ ++ + E E L +K I L S ++ +EL +EN+ L NL+ E V
Sbjct: 314 LQELSDQQQMVQELTA-ENEKLVDEKTI--LETSFHQHRERADELSQENEKLMNLLQERV 370
Query: 159 TESDNLNKEVDDLKKNNEC---LTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQSL 215
+ +E ++ +C L Q + EKL+N I + C+ K++E +L
Sbjct: 371 KNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN-----IQQQLTCSLRKVEEENQGAL 425
Query: 216 HIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEP 275
+ L + N +++ R+N + L+ R + L + S+K+HL+ +
Sbjct: 426 EM--IKRLKEENEKLNEFLELERHNN-NMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 482
Query: 276 NMT-MDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSKDHIDRYKDSLLA 334
T E+ E+ E + + +KV + +++L LS + E K+ I ++ SLLA
Sbjct: 483 KATEASAVEQTAESCEVQ-EMLKV-ARAEKDLLELSCNELRQELLKANGEI-KHVSSLLA 539
Query: 335 VLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASL 394
++ ++ + + D+ +++ K+Q +E +E+K + E + L
Sbjct: 540 KVEKDY-----SYLKEICDH-------QAEQLSRTSLKLQEKASESDAEIKDMKETIFEL 587
Query: 395 NSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRD 454
Q +E+ A + + I E+ S+V I + +++++L+ L K K K + + R
Sbjct: 588 EDQ-VEQHRAVKL--HNNQLISELESSV-IKLEEQKSDLERQL-KTLTKQMKEETEEWRR 642
Query: 455 LDQDL 459
DL
Sbjct: 643 FQADL 647
Score = 54.4 bits (125), Expect = 2e-06
Identities = 62/233 (26%), Positives = 111/233 (47%), Gaps = 25/233 (10%)
Query: 527 SLHEELTKLYKSKVDENNANLNLIKILSEEIDALK--IAIAKNEEKMLSLSEKDNKLTEL 584
++ ++LT + +EN L +IK L EE + L + + ++ M++ + L E
Sbjct: 405 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKT-----LEEC 459
Query: 585 VSTINGLKEENNSLKSLNDVITREKETQASELER---SCQVIKQNGFELDKMKADIL-MX 640
T+ GLK EN SLKS + ++K T+AS +E+ SC+V Q ++ + + D+L +
Sbjct: 460 RVTLEGLKMENGSLKS-HLQGEKQKATEASAVEQTAESCEV--QEMLKVARAEKDLLELS 516
Query: 641 XXXXXXXXXXXXXXXDEAKSLL---EQNLA-LKEQCEEKTRDCSR--LEINIKTHEKTAE 694
SLL E++ + LKE C+ + SR L++ K E AE
Sbjct: 517 CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAE 576
Query: 695 IQN--RMIMRLQKQIQEDDKLFIEKETKLNELTN---KYEALKRDYDAAVKDL 742
I++ I L+ Q+++ + + ++EL + K E K D + +K L
Sbjct: 577 IKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 629
Score = 47.2 bits (107), Expect = 3e-04
Identities = 131/641 (20%), Positives = 254/641 (39%), Gaps = 75/641 (11%)
Query: 108 LMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLS-NLIMENVTESD---- 162
L SQ++ L E KD EI L LK +K E D L N+ +V+ D
Sbjct: 85 LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPM 144
Query: 163 ---------NLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQ 213
N KE+ DL++ N L +K I LE S N G + ++ Q
Sbjct: 145 IRALEEKNKNFQKELSDLEEENRVLKEKLIYLE----HSPNSEGAASHTGDSSCPTSITQ 200
Query: 214 SLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELH 273
G T ++L+ I + + N + T S + + K S H+
Sbjct: 201 ESSFG-SPTGNQLSSDIDEYKKNIHGNALRTSGS---SSSDVTKASLSPDASNFEHITAE 256
Query: 274 EPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNE------SKKSKDHIDR 327
P+ + ++++ T S + +L SL+E++ E +++ + +
Sbjct: 257 TPSRPLSSTSNPFKSSKCSTARSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE 316
Query: 328 YKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSV 387
D V + L + +++ ++++ DE+ ++ K+ L E +
Sbjct: 317 LSDQQQMVQELTAENEKLVDEKTILETSFHQHRERADELSQENEKLMNLLQE-----RVK 371
Query: 388 NEKLASLNSQLIEKENAC-NIL---RIQKERIHEISSAVTIDIVKKENELKEILTKECLK 443
NE+ + ++IE E C IL R ++E++ I +T + K E E + L E +K
Sbjct: 372 NEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL--EMIK 429
Query: 444 LSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAVXXX 503
+LK + + L++ L + + + + + E L++E G+ K+
Sbjct: 430 --RLKEENEK-LNEFLELERHNNNMMAKTL-------EECRVTLEGLKMENGSLKSHLQG 479
Query: 504 XXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIA 563
T E EV +E+ K+ +++ D + N ++ +E+
Sbjct: 480 EKQKATEASAVEQTAESC--EV----QEMLKVARAEKDLLELSCNELR---QELLKANGE 530
Query: 564 IAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVI 623
I K+ +L+ EKD + + + SLK +EK ASE + + +
Sbjct: 531 I-KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLK------LQEK---ASESDAEIKDM 580
Query: 624 KQNGFELD---KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNL-ALKEQCEEKTRDC 679
K+ FEL+ + + + +E KS LE+ L L +Q +E+T +
Sbjct: 581 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEW 640
Query: 680 SRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETK 720
R + +++T + N + Q++++ + +E+E K
Sbjct: 641 RRFQADLQT---AVVVANDIKCEAQQELRTVKRKLLEEEEK 678
Score = 38.3 bits (85), Expect = 0.15
Identities = 33/127 (25%), Positives = 59/127 (46%), Gaps = 12/127 (9%)
Query: 832 QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKE 891
+L+E+ E+ D+KE EL+D+ E ++ + L+ + LE+Q S+L+
Sbjct: 565 KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLER 624
Query: 892 QIRT-----QQPVERQAKF------ADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLM 940
Q++T ++ E +F A V N + A V R + E EKN RL
Sbjct: 625 QLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEE-EKNARLQ 683
Query: 941 KTIEELR 947
K + +++
Sbjct: 684 KELGDVQ 690
Score = 36.7 bits (81), Expect = 0.46
Identities = 44/205 (21%), Positives = 94/205 (45%), Gaps = 15/205 (7%)
Query: 823 SVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSL 882
+V +E +++E L + E D L+ EL E ++ A+++K+ L
Sbjct: 489 AVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL 548
Query: 883 EQQVSNLKEQI-RTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVE-KNKRLM 940
++ + EQ+ RT ++ +A +D + +D + D++ V+ N +L+
Sbjct: 549 KEICDHQAEQLSRTSLKLQEKASESDAEI---KDMKETIFELEDQVEQHRAVKLHNNQLI 605
Query: 941 KTIE----ELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYK 996
+E +L +K DL+ + + K M++ T++ + F+A +L+ ++K
Sbjct: 606 SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA---DLQTAVVVANDIK---C 659
Query: 997 ELDEECETCAEYLKQREEQCKRLKE 1021
E +E T L + EE+ RL++
Sbjct: 660 EAQQELRTVKRKLLEEEEKNARLQK 684
Score = 35.1 bits (77), Expect = 1.4
Identities = 44/208 (21%), Positives = 96/208 (46%), Gaps = 26/208 (12%)
Query: 835 ERLLSCQQELDDLKERYKELDDECETCAEY--LQERDEQCARLKKEKLSLEQQ--VSNLK 890
E L + QEL D ++ +EL E E + + E R + ++LS E + ++ L+
Sbjct: 308 EELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERADELSQENEKLMNLLQ 367
Query: 891 EQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKK 950
E+++ ++P ++ K ++ + ++++ ++ E N + T LR +
Sbjct: 368 ERVKNEEPTTQEGKIIELEQKC--------TGILEQGRFEREKLLNIQQQLTCS-LRKVE 418
Query: 951 QDLKNTVTKMQKAMEKYTKKDKEFEAKR-------KELEDCKAELEELKQRYKEL----- 998
++ + + +++ E+ K ++ E +R K LE+C+ LE LK L
Sbjct: 419 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 478
Query: 999 -DEECETCAEYLKQREEQCKRLKEAKIA 1025
+++ T A ++Q E C+ + K+A
Sbjct: 479 GEKQKATEASAVEQTAESCEVQEMLKVA 506
Score = 33.5 bits (73), Expect = 4.3
Identities = 36/138 (26%), Positives = 65/138 (47%), Gaps = 13/138 (9%)
Query: 56 SCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKS- 114
S K+ + ES EI E + EL D EQ A++ LI E ++ + + + KS
Sbjct: 563 SLKLQEKASESDAEIKDMKETIF-ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSD 621
Query: 115 LEMENLTKDKEIKNLTDS-------LKTKSKKINEL----QEENDTLSNLIMENVTESDN 163
LE + T K++K T+ L+T N++ Q+E T+ ++E ++
Sbjct: 622 LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNAR 681
Query: 164 LNKEVDDLKKNNECLTQK 181
L KE+ D++ + +T +
Sbjct: 682 LQKELGDVQGHGRVVTSR 699
>BC043398-1|AAH43398.1| 805|Homo sapiens CEP290 protein protein.
Length = 805
Score = 58.8 bits (136), Expect = 1e-07
Identities = 146/745 (19%), Positives = 327/745 (43%), Gaps = 77/745 (10%)
Query: 36 NIIETQSNPIKLQDSGTITISCKMCQSL-KESSNEINLKLEKL--SGE---LFD--IKEQ 87
++ + + N +K + + ++ QSL K + E+ L LE++ +GE F+ +K +
Sbjct: 31 SLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTK 90
Query: 88 KSALEGKYQNLILETQTRD--LLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQE 145
LE + + RD L ++I LE + KD+E++++ L+ K KK+NE
Sbjct: 91 VMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELE-KEKKVNEQL- 148
Query: 146 ENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI----GPKNI 201
L N EN E+ L +E LKK NE L Q ID +K ++ + + G +
Sbjct: 149 ---ALRNEEAEN--ENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSD 203
Query: 202 CAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCE 261
K+N ++ TL++ N I N R N L+ ++ +++ +
Sbjct: 204 YRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN--------LEESVQEMEKMTD 255
Query: 262 DFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKS 321
++ +K +H+ + +D +K EN+ ++ + V+ ++++ ++ N + ++ + K
Sbjct: 256 EYNRMK--AIVHQTDNVIDQLKK--ENDHYQLQ-VQELTDLLKSKNEEDDPIMVAVNAK- 309
Query: 322 KDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQ-IDLDEILEKYTKVQGDLNEC 380
++ +K +L+ D E + ++ ++ N+ K + LD +Q + E
Sbjct: 310 ---VEEWK-LILSSKDDE-----IIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER 360
Query: 381 TSELKSVNEKLASLNSQLIEKENACNILRIQKE-RIHEISSAVTIDIVKKENELKEIL-- 437
S++K + E++ ++ ++N C I ++ E + ++ +S ++ K +IL
Sbjct: 361 DSQIKMLTEQVEQYTKEM--EKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKE 418
Query: 438 -TKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGT 496
TKE + ++L R+ D++L K +++ + E + + + K ++++
Sbjct: 419 KTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDRE 478
Query: 497 AKAVXXXXXXXXXXXXXXFDTLEEAHNEV---KSLHEELTKLYKSKVDENNANLNLIKIL 553
+ + D E V +LT+ SK + +IL
Sbjct: 479 IEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQIL 538
Query: 554 SEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLK---SLNDVITREKE 610
+EI++L+ ++K+ ++++ K S +GL E+ +L S D I+ E++
Sbjct: 539 LKEIESLEEERLDLKKKIRQMAQERGKR----SATSGLTTEDLNLTENISQGDRIS-ERK 593
Query: 611 TQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKE 670
L+ + +N F + +++ ++ K L+E+N L+E
Sbjct: 594 LDLLSLKNMSEAQSKNEF----LSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEE 649
Query: 671 QCEEKTRDCSRL--EINIKTHEKTAEIQN--RMIMRLQ-KQIQEDDKLFIEKETKLNELT 725
+E + + + ++K E + I + R++ ++ K + + + ++++LT
Sbjct: 650 GMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLT 709
Query: 726 NKYEALKRDYDAAVKDLESSREAVN 750
+ E L+++ ES +EA+N
Sbjct: 710 GRNEELRQEL------RESRKEAIN 728
Score = 47.2 bits (107), Expect = 3e-04
Identities = 117/611 (19%), Positives = 242/611 (39%), Gaps = 45/611 (7%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANL-NLIKILSEEIDALKIAIAKNEEKMLS--L 574
+E A EV+ EE K +++++ L N +++ + +NE L L
Sbjct: 66 VELALEEVEKAGEEQAK-FENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
Query: 575 SEKDNKLTELVSTINGLKEENNSL-------KSLNDVITREKETQASELERSCQVIKQNG 627
+KD +L ++ + K+ N L ++ N + RE + + E+ CQ I
Sbjct: 125 EQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQ 184
Query: 628 FELDKMKADILMXXXXXXXXXXXXXXXX-------DEAKSLLEQNLALKEQCEEKTRDCS 680
++D K +L DE ++L E N ++ Q +E ++
Sbjct: 185 KQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN-- 242
Query: 681 RLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE---TKLNELTNKYEALKRDYDA 737
LE +++ EK + NRM + + D+L E + ++ ELT+ ++ + D
Sbjct: 243 -LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDP 301
Query: 738 AVKDLESSREAVNQLTTQKD--LVEGR--IAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
+ + + E + + KD ++E + + L ++ Q
Sbjct: 302 IMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERD 361
Query: 794 XXXXXXTFGDEN--RDLGENPKLDDSPKRSISVISDSEVSQLKERL-LSCQQELDDLKER 850
T E +++ +N + + K + + S L ++ + Q LD LKE+
Sbjct: 362 SQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQ--RNKGASTLSQQTHMKIQSTLDILKEK 419
Query: 851 YKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAV 910
KE + E +E+D++ K E V L++ + + + Q K D +
Sbjct: 420 TKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREI 479
Query: 911 N-TDEDWANLHSVVVDRMSYDAEVEKNKRL-MKTIEELRYKKQDLKNTVTKMQKAMEKYT 968
++ L + D + + + + L KT+ +L + ++ K+ + +A +
Sbjct: 480 EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLT-EFRNSKHLKQQQYRAENQIL 538
Query: 969 KKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQRE--EQCKRLKEAKIAL 1026
KE E+ +E D K ++ ++ Q + E L E Q R+ E K+ L
Sbjct: 539 L--KEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDL 596
Query: 1027 EIVDKLSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQ-QITDVMKENQKLKKMNA 1085
L N A K E LS + + + I + Q ++ ++++EN++L++
Sbjct: 597 L---SLKNMSEAQSKN-EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMK 652
Query: 1086 KLITICKKRGK 1096
+++ K+ K
Sbjct: 653 EILQAIKEMQK 663
>AK222832-1|BAD96552.1| 678|Homo sapiens CCAAT displacement protein
isoform b variant protein.
Length = 678
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/264 (24%), Positives = 125/264 (47%), Gaps = 27/264 (10%)
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT-Q 896
L Q+L +R +++ E + E L+E +++ A +K ++++++ LKE+IR +
Sbjct: 106 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA----LKEKIREYE 161
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
Q ++ QA+ +A+ ++ N +R + ++ +L EE +K Q L+
Sbjct: 162 QTLKNQAE--TIALEKEQKLQN-DFAEKERKLQETQMSTTSKL----EEAEHKVQSLQTA 214
Query: 957 VTKMQKAM-EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK----- 1010
+ K + + + TK D+E AK E+E +LE QR + E ET E L
Sbjct: 215 LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHS 274
Query: 1011 -QREEQCKRLKEAKIALEIVDK--LSNQKVALEKQI----ESLSNTPVSNSTMYVATGSA 1063
Q Q ++ + + A+E++ + L + A E++I E + S + + + S
Sbjct: 275 LQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQ 334
Query: 1064 IVQNQQITDVMKENQKLKKMNAKL 1087
I Q +Q + +N LK++ KL
Sbjct: 335 ISQLEQ--QLSAKNSTLKQLEEKL 356
Score = 43.2 bits (97), Expect = 0.005
Identities = 85/402 (21%), Positives = 163/402 (40%), Gaps = 43/402 (10%)
Query: 318 SKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQID-----LDEILEKYTK 372
SK+SK+ + + ++D +LD+ + L + + I+ L E LE+Y K
Sbjct: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138
Query: 373 VQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENE 432
++ +K++ EK+ L +N + ++KE+ + D +KE +
Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTL---KNQAETIALEKEQ------KLQNDFAEKERK 189
Query: 433 LKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDY--EIEKEKL 490
L+E KL + + + + L L K T LFD L T+Y+ T EIE
Sbjct: 190 LQETQMSTTSKLEEAEHKV-QSLQTAL--EKTRTELFD-LKTKYDEETTAKADEIEMIMT 245
Query: 491 RLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLI 550
LE +A +TL E + + +++ K+ E +
Sbjct: 246 DLERANQRAEVAQREA---------ETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTR 296
Query: 551 KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE-LVSTINGLKEE----NNSLKSLNDVI 605
L E+ A + IA+ E + L KL E S I+ L+++ N++LK L + +
Sbjct: 297 SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKL 356
Query: 606 TREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQN 665
+ + + E+++ ++K F + ++ +SL +N
Sbjct: 357 KGQADYE--EVKKELNILKSMEFAPSE-------GAGTQDAAKPLEVLLLEKNRSLQSEN 407
Query: 666 LALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQI 707
AL+ + + C+ L++ I TA Q +I RL++ +
Sbjct: 408 AALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDL 449
Score = 37.9 bits (84), Expect = 0.20
Identities = 49/248 (19%), Positives = 117/248 (47%), Gaps = 26/248 (10%)
Query: 813 KLDDSPKRSISVISDSE--VSQLKERLLSCQQELDDLKERYKE----LDDECETCAEYLQ 866
KL ++ + S + ++E V L+ L + EL DLK +Y E DE E L+
Sbjct: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
+++ ++E +L +Q+S+ ++ +++ A + A+ V+ R
Sbjct: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQK-APDVEQAIE-----------VLTR 296
Query: 927 MSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTKM-QKAMEKYTKKDKEFEAKRKELEDC 984
S + E+ K + + + +E++ Q L+ ++TK+ + + + ++ +++ AK L+
Sbjct: 297 SSLEVELAAKEREIAQLVEDV----QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 352
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+ +L+ + Y+E+ +E + ++ + ++A LE++ N+ + E
Sbjct: 353 EEKLKG-QADYEEVKKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410
Query: 1045 SLSNTPVS 1052
+SN+ +S
Sbjct: 411 RISNSDLS 418
>AC005086-1|AAP22331.1| 317|Homo sapiens unknown protein.
Length = 317
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/264 (24%), Positives = 125/264 (47%), Gaps = 27/264 (10%)
Query: 838 LSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRT-Q 896
L Q+L +R +++ E + E L+E +++ A +K ++++++ LKE+IR +
Sbjct: 5 LDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA----LKEKIREYE 60
Query: 897 QPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNT 956
Q ++ QA+ +A+ ++ N +R + ++ +L EE +K Q L+
Sbjct: 61 QTLKNQAE--TIALEKEQKLQN-DFAEKERKLQETQMSTTSKL----EEAEHKVQSLQTA 113
Query: 957 VTKMQKAM-EKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLK----- 1010
+ K + + + TK D+E AK E+E +LE QR + E ET E L
Sbjct: 114 LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHS 173
Query: 1011 -QREEQCKRLKEAKIALEIVDK--LSNQKVALEKQI----ESLSNTPVSNSTMYVATGSA 1063
Q Q ++ + + A+E++ + L + A E++I E + S + + + S
Sbjct: 174 LQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQ 233
Query: 1064 IVQNQQITDVMKENQKLKKMNAKL 1087
I Q +Q + +N LK++ KL
Sbjct: 234 ISQLEQ--QLSAKNSTLKQLEEKL 255
Score = 37.9 bits (84), Expect = 0.20
Identities = 49/248 (19%), Positives = 117/248 (47%), Gaps = 26/248 (10%)
Query: 813 KLDDSPKRSISVISDSE--VSQLKERLLSCQQELDDLKERYKE----LDDECETCAEYLQ 866
KL ++ + S + ++E V L+ L + EL DLK +Y E DE E L+
Sbjct: 88 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 147
Query: 867 ERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDR 926
+++ ++E +L +Q+S+ ++ +++ A + A+ V+ R
Sbjct: 148 RANQRAEVAQREAETLREQLSSANHSLQLASQIQK-APDVEQAIE-----------VLTR 195
Query: 927 MSYDAEV-EKNKRLMKTIEELRYKKQDLKNTVTKM-QKAMEKYTKKDKEFEAKRKELEDC 984
S + E+ K + + + +E++ Q L+ ++TK+ + + + ++ +++ AK L+
Sbjct: 196 SSLEVELAAKEREIAQLVEDV----QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 251
Query: 985 KAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLSNQKVALEKQIE 1044
+ +L+ + Y+E+ +E + ++ + ++A LE++ N+ + E
Sbjct: 252 EEKLKG-QADYEEVKKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 309
Query: 1045 SLSNTPVS 1052
+SN+ +S
Sbjct: 310 RISNSDLS 317
Score = 33.1 bits (72), Expect = 5.7
Identities = 57/240 (23%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L E LE+Y K ++ +K++ EK+ L +N + ++KE+ +
Sbjct: 28 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL---KNQAETIALEKEQ------KL 78
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTD 482
D +KE +L+E KL + + + + L L K T LFD L T+Y+ T
Sbjct: 79 QNDFAEKERKLQETQMSTTSKLEEAEHKV-QSLQTAL--EKTRTELFD-LKTKYDEETTA 134
Query: 483 Y--EIEKEKLRLETGT--AKAVXXXXXXXXXXXXXXFDTLEEAHNEVKS--LHEELTKLY 536
EIE LE A+ +L+ A K+ + + + L
Sbjct: 135 KADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 194
Query: 537 KSKVD-ENNANLNLIKILSEEIDALKIAIAKNEEKMLS-LSEKDNKLTELVSTINGLKEE 594
+S ++ E A I L E++ L+ ++ K E S +S+ + +L+ ST+ L+E+
Sbjct: 195 RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 254
>AB059622-1|BAB69690.1| 1594|Homo sapiens Rb1-inducible coiled coil
protein protein.
Length = 1594
Score = 58.8 bits (136), Expect = 1e-07
Identities = 119/564 (21%), Positives = 232/564 (41%), Gaps = 56/564 (9%)
Query: 357 NKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLI----EKENACNILRIQK 412
N+Y+ LD ++++ + + + + EL + E L + +++ EKE + +
Sbjct: 872 NEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKD 931
Query: 413 ERIHEISSAVTIDI--VKKENELKEILTKECLKL---SKLKIDIPRDLDQDLPAHKKITI 467
+++ E+ + + +K+ + +EI+ ++ KL + K+ + R Q L +
Sbjct: 932 QKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLE-QSHLKE 990
Query: 468 LFDAL----ITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHN 523
L D L I ++E TD+ + E+L+ E + + L+E
Sbjct: 991 LEDTLQVRHIQEFEKVMTDHRVSLEELKKEN--QQIINQIQESHAEIIQEKEKQLQELKL 1048
Query: 524 EVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTE 583
+V L + KL + ++ A + IKIL EE A + K K L E +N TE
Sbjct: 1049 KVSDLSDTRCKL-EVELALKEAETDEIKILLEESRAQQ----KETLKSLLEQETENLRTE 1103
Query: 584 LVSTINGLKEENNS-----LKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADIL 638
+S +N ++NN L L ++T EK+ + SEL I ++ E + +KA++
Sbjct: 1104 -ISKLNQKIQDNNENYQVGLAELRTLMTIEKDQRISEL------ISRHEEESNILKAEL- 1155
Query: 639 MXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNR 698
+ K+L EQ + L+ + + + R + T ++ E
Sbjct: 1156 ------NKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE--EKYEA 1207
Query: 699 MIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRD-YDAAVKDLESSREAVNQLTTQKD 757
+I L+K Q KL +E +L K K + A+K+ + RE V +K+
Sbjct: 1208 IIQNLEKDRQ---KLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVV-----EKE 1259
Query: 758 LVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDS 817
L+E ++ LE+ I F ++ + E K ++
Sbjct: 1260 LLE-KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQ-EKRKNEEM 1317
Query: 818 PKRSISVISDSEVS---QLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCAR 874
S+I++ + + L + + ++DL ++ K + E + ++ E AR
Sbjct: 1318 QNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRAR 1377
Query: 875 LKKEKLSLEQQVSNLKEQIRTQQP 898
L +EK LE++VS L+ P
Sbjct: 1378 LLEEKKKLEEEVSKLRSSSFVPSP 1401
Score = 44.8 bits (101), Expect = 0.002
Identities = 80/365 (21%), Positives = 161/365 (44%), Gaps = 23/365 (6%)
Query: 25 NQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQ--SLKES-SNEINLKLEKLSGEL 81
NQ+ + ++ E Q +KL+ S CK+ +LKE+ ++EI + LE+ +
Sbjct: 1026 NQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQ- 1084
Query: 82 FDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKIN 141
+ KS LE + +NL E L +I+ E++ L K ++I+
Sbjct: 1085 -QKETLKSLLEQETENLRTEISK---LNQKIQDNNENYQVGLAELRTLMTI--EKDQRIS 1138
Query: 142 ELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE-KLVNE--SENKIGP 198
EL ++ SN++ + + +L+ + +++KN L ++ I+L+ KL +E + +
Sbjct: 1139 ELISRHEEESNILKAELNKVTSLHNQAFEIEKN---LKEQIIELQSKLDSELSALERQKD 1195
Query: 199 KNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKE 258
+ I Q + E +IQ+L +S + K +Q+ L + + +
Sbjct: 1196 EKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREV 1255
Query: 259 LCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNES 318
+ ++ HLE ++ + +D G+++ + + + E K EQL E
Sbjct: 1256 VEKELLEKVKHLE-NQIAKSPAIDSTRGDSSSLVAELQEKLQEEKA---KFLEQLEEQEK 1311
Query: 319 KKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLN 378
+K+++ + + SL+A F T L ++ +NIIN L +++ + DL
Sbjct: 1312 RKNEE-MQNVRTSLIAEQQTNFNTV-LTREKMRKENIINDLSDKLKSTMQQQER-DKDLI 1368
Query: 379 ECTSE 383
E SE
Sbjct: 1369 ESLSE 1373
Score = 41.5 bits (93), Expect = 0.016
Identities = 130/620 (20%), Positives = 248/620 (40%), Gaps = 57/620 (9%)
Query: 24 RNQLDGAKSKNDNIIETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFD 83
+ Q D + S +E ++ K++ S IT+ K + L NE KL+ L
Sbjct: 828 KEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGL------ 881
Query: 84 IKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINEL 143
IKE + E K + L ++ LE KD E +K + + + L
Sbjct: 882 IKETEEN-ENKIKK----------LKGELVCLEEVLQNKDNEFA----LVKHEKEAVICL 926
Query: 144 QEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKI----GPK 199
Q E D L MEN+ S N E+ +LK++ E + + DL+KL E++ K+
Sbjct: 927 QNEKDQ-KLLEMENIMHSQNC--EIKELKQSREIVLE---DLKKLHVENDEKLQLLRAEL 980
Query: 200 NICAQCKLK--ENLIQSLHI-GYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDC 256
Q LK E+ +Q HI ++ ++ S+ + + +S + +E
Sbjct: 981 QSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE 1040
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINN 316
K+L E + + L + ++L K E +E + + ++ K L SL EQ N
Sbjct: 1041 KQLQELKLKVSD-LSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETEN 1099
Query: 317 ---ESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKV 373
E K I ++ L AE T + + +I++++ + + + + KV
Sbjct: 1100 LRTEISKLNQKIQDNNENYQVGL-AELRTLMTIEKDQRISELISRHEEESNILKAELNKV 1158
Query: 374 QGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENEL 433
N+ K++ E++ L S+L + +A + R + E+I + I E +
Sbjct: 1159 TSLHNQAFEIEKNLKEQIIELQSKLDSELSA--LERQKDEKITQQEEKYEAIIQNLEKDR 1216
Query: 434 KEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDY---EIEKEKL 490
+++++ + +L + + D+ + K L ++ + L + + +I K
Sbjct: 1217 QKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPA 1276
Query: 491 RLET-GTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNL 549
T G + ++ F LE+ + K +EE+ + S + E N N
Sbjct: 1277 IDSTRGDSSSLVAELQEKLQEEKAKF--LEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNT 1334
Query: 550 I---------KILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKS 600
+ I+++ D LK + + E + L+ L+EE + L+S
Sbjct: 1335 VLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRS 1394
Query: 601 LNDVITREKETQASELERSC 620
+ V + T A EL +C
Sbjct: 1395 SSFVPSPYVAT-APELYGAC 1413
>AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A
protein.
Length = 1016
Score = 58.4 bits (135), Expect = 1e-07
Identities = 109/571 (19%), Positives = 232/571 (40%), Gaps = 37/571 (6%)
Query: 518 LEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEK 577
L + + ++L ++L K+ K ++ + + +EI L+ + K + +SE
Sbjct: 405 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEH 463
Query: 578 DNKLTELVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIKQNGFELDKMKADI 637
+ E ++ N LKE+ + L KE +++ + I++ F + +++ +
Sbjct: 464 QTREVEQLA--NHLKEKTDKCSEL----LLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 517
Query: 638 LMXXXXXXXXXXXXXXXXDEAK---SLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAE 694
L+ EAK SL Q A ++ + K ++ + LE ++ + E
Sbjct: 518 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 577
Query: 695 IQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQLTT 754
+N + +L Q++ K E T+L EL + + K D + ++ S +A++ T
Sbjct: 578 NKNEEVQQLHMQLEIQKK---ESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMS--TQ 631
Query: 755 QKDLVEGRIAEL--ESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENP 812
+ ++ G+ A++ E ++ +Q + + RDL
Sbjct: 632 DQHVLFGKFAQIIQEKEVEIDQ---LNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI 688
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
+ S + + + E+ QL E + QQEL ++ ++ + +E Q
Sbjct: 689 ECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSM---NAHSLSEEADSLKHQL 745
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYD-- 930
+ EKL+LEQQV E++ + V ++ F ++ L S+ +R S +
Sbjct: 746 DVVIAEKLALEQQVETANEEMTFMKNVLKETNF-----KMNQLTQELFSLKRERESVEKI 800
Query: 931 AEVEKNKRLMKTIEELRYKKQDLKNTVTK-MQKAMEKYTKKDKEFEAKRKELEDCKAELE 989
+ +N + I+ L K +L+ +T+ K++E T E + + + + L
Sbjct: 801 QSIPENS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFRSFEENGKGSIINLETRLL 859
Query: 990 ELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALEIVD--KLSNQKVALEKQIESLS 1047
+L+ D E C + +K +EQ + + + +IV+ K+ +KVA + +
Sbjct: 860 QLESTVSAKDLELTQCYKQIKDMQEQ-GQFETEMLQKKIVNLQKIVEEKVA-AALVSQIQ 917
Query: 1048 NTPVSNSTMYVATGSAIVQNQQITDVMKENQ 1078
V + I + T++ NQ
Sbjct: 918 LEAVQEYAKFCQDNQTISSEPERTNIQNLNQ 948
Score = 47.2 bits (107), Expect = 3e-04
Identities = 99/506 (19%), Positives = 202/506 (39%), Gaps = 47/506 (9%)
Query: 566 KNEEKMLSLSEKDNKLTE-LVSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
+NEE ML++S + E L+ I+ + K + RE Q E S + +
Sbjct: 195 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 254
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLEI 684
+ L + DE K+L E+ Q +EKT RLE
Sbjct: 255 ELRERLHEESRAREQLAVELSKAEGVIDGYADE-KTLFER------QIQEKTDIIDRLEQ 307
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFI-EKETKLNELTNKYEALKRDYDAAVKDLE 743
+ A + + + Q+QIQE+ +L +KE E + L ++ + +K+
Sbjct: 308 ELLC----ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE-- 361
Query: 744 SSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGD 803
E Q +D ++ ++ LE D+ + + + +
Sbjct: 362 -KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 420
Query: 804 ENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAE 863
+ R + +D +R + E+ +L+++L + E E E A
Sbjct: 421 KMRKFLDEQAIDREHERDVF---QQEIQKLEQQL-KVVPRFQPISEHQTR---EVEQLAN 473
Query: 864 YLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVV 923
+L+E+ ++C+ L K L++ + E+I + +E + + + A+ A+ V
Sbjct: 474 HLKEKTDKCSELLLSKEQLQRDIQERNEEI---EKLEFRVRELEQALLVS---ADTFQKV 527
Query: 924 VDRMSYDA-----EVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKR 978
DR + A E+ +L + + K++++ N ++++ E+ K++E +
Sbjct: 528 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 587
Query: 979 KELEDCKAE----LEELKQRYKELDEECETCAEYLKQRE---EQCKRLKEAKIALEI--- 1028
+LE K E L+EL+Q K ++ E +K+ + Q + + K A I
Sbjct: 588 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK 647
Query: 1029 ---VDKLSNQKVALEKQIESLSNTPV 1051
+D+L+ Q L++Q++ ++ V
Sbjct: 648 EVEIDQLNEQVTKLQQQLKITTDNKV 673
Score = 46.0 bits (104), Expect = 8e-04
Identities = 64/282 (22%), Positives = 118/282 (41%), Gaps = 20/282 (7%)
Query: 38 IETQSNPIKLQDSGTITISCKMCQSLKESSNEINLKLEKLSGELFDIKEQKSALEGKYQN 97
+E Q K++D + ++ S I L+ EK + EL D+++Q ALE + +
Sbjct: 363 LEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK-NTELMDLRQQNQALEKQLEK 421
Query: 98 LILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKT--KSKKINELQ-EENDTLSNLI 154
+ R L Q E E +EI+ L LK + + I+E Q E + L+N +
Sbjct: 422 M------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 475
Query: 155 MENVTESDNLNKEVDDLKKNNECLTQKCIDLEKLVNESENKIGPKNICAQCKLKENLIQS 214
E + L + L+++ + ++ LE V E E + + +
Sbjct: 476 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-----LVSADTFQKVEDR 530
Query: 215 LHIGYDNTLSKLNRSI---SDSNTSTRYNK-ICTLQSELDAGREDCKELCEDFTSIKNHL 270
H G +L+ + ++ + R K I L+ +L+ RE+ + E+ + L
Sbjct: 531 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 590
Query: 271 ELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQ 312
E+ + T L E EN F+ K+ IK + +++S Q
Sbjct: 591 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES-DAMSTQ 631
Score = 40.7 bits (91), Expect = 0.028
Identities = 71/379 (18%), Positives = 181/379 (47%), Gaps = 27/379 (7%)
Query: 69 EINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDKEI-- 126
E +++++L+ ++ +++Q L+ N ++E + L+ +++ ++E L D+E
Sbjct: 646 EKEVEIDQLNEQVTKLQQQ---LKITTDNKVIEEKNE--LIRDLET-QIECLMSDQECVK 699
Query: 127 KNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCIDLE 186
+N + ++ ++ I +LQ+E L+N+ + + +L++E D LK + + + + LE
Sbjct: 700 RNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 756
Query: 187 KLV-NESENKIGPKNICAQCKLKEN-LIQSL-HIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+ V +E KN+ + K N L Q L + + + +SI +++ + + +
Sbjct: 757 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLS 816
Query: 244 TLQSELDAG-REDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEI 302
+ EL+ ED + E+ T ++ E + ++L+ +L + + +++
Sbjct: 817 KDKPELEVVLTEDALKSLENQTYFRS-FEENGKGSIINLETRLLQLESTVSAKDLELTQC 875
Query: 303 KRNLNSLSEQLINNESKKSKDHIDRYK---DSLLAVLDAEFGTTSLDVF-EILMDNIINK 358
+ + + EQ K ++ K + + A L ++ ++ + + DN
Sbjct: 876 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTIS 935
Query: 359 YQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEI 418
+ + I + +++ D E S++ ++ +++ L SQ++E + L ++KE++ EI
Sbjct: 936 SEPERTNI-QNLNQLRED--ELGSDISALTLRISELESQVVEMHTS---LILEKEQV-EI 988
Query: 419 SSAVTIDIVKKENELKEIL 437
+ ++ KK EL+++L
Sbjct: 989 AEKNVLEKEKKLLELQKLL 1007
Score = 40.3 bits (90), Expect = 0.037
Identities = 101/520 (19%), Positives = 208/520 (40%), Gaps = 38/520 (7%)
Query: 257 KELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLN--SLSEQLI 314
++L E + + LE + T + E + E T+++K E++ L+ S + + +
Sbjct: 212 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-ATESLKCQEELRERLHEESRAREQL 270
Query: 315 NNESKKSKDHIDRYKDS-LLAVLDAEFGTTSLDVFE---ILMDNIINKYQIDLDEILEKY 370
E K++ ID Y D L + T +D E + N + + + + +I E+
Sbjct: 271 AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER 330
Query: 371 TKVQGDLNECTSELKSVNEKLASLNSQLIEK--ENACNILRIQKERIHEISSAVTIDIVK 428
+ +E V ++L +L+++ E C +++ + ++ A+ ID+ +
Sbjct: 331 ELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVK-ALEIDVEE 389
Query: 429 KENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKE 488
+ + E+ ++ +L L+ + L++ L +K D E R ++ E +
Sbjct: 390 QVSRFIELEQEKNTELMDLRQQ-NQALEKQLEKMRKF---LDEQAIDREHERDVFQQEIQ 445
Query: 489 KLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLN 548
KL + + L+E ++ L +L + + E N +
Sbjct: 446 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD-IQERNEEIE 504
Query: 549 LIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR- 607
++ E++ + A +K+ +D K V L E L++ D I R
Sbjct: 505 KLEFRVRELEQALLVSADTFQKV-----EDRKHFGAVEAKPELSLEVQ-LQAERDAIDRK 558
Query: 608 EKE-TQASE-LERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQ- 664
EKE T E LE+ + ++ E+ ++ + + K +E+
Sbjct: 559 EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 618
Query: 665 NLALKEQCEEKTRDCSRL--EINIKTHEKTAEIQ--NRMIMRLQKQ---------IQEDD 711
LA+KE T+D L + EK EI N + +LQ+Q I+E +
Sbjct: 619 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 678
Query: 712 KLFIEKETKLNELTNKYEALKRDYDAAVKDLESSREAVNQ 751
+L + ET++ L + E +KR+ + ++ L E + Q
Sbjct: 679 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ 718
Score = 34.7 bits (76), Expect = 1.9
Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 15/141 (10%)
Query: 63 LKESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTR---DLLMSQIKSLEMEN 119
+K E N K+ +L+ ELF +K ++ ++E K Q+ I E D L LE+
Sbjct: 769 MKNVLKETNFKMNQLTQELFSLKRERESVE-KIQS-IPENSVNVAIDHLSKDKPELEVV- 825
Query: 120 LTKD--KEIKNLT--DSLKTKSK-KINELQEENDTLSNLIMENVTESDNLNKEVDDLKK- 173
LT+D K ++N T S + K I L+ L + + E K++ D+++
Sbjct: 826 LTEDALKSLENQTYFRSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 885
Query: 174 ---NNECLTQKCIDLEKLVNE 191
E L +K ++L+K+V E
Sbjct: 886 GQFETEMLQKKIVNLQKIVEE 906
>AL590431-10|CAH71268.1| 247|Homo sapiens tropomyosin 3 protein.
Length = 247
Score = 58.4 bits (135), Expect = 1e-07
Identities = 51/231 (22%), Positives = 108/231 (46%), Gaps = 13/231 (5%)
Query: 830 VSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL 889
+ +K ++ QQ+ DD +ER + L E E ++ + + A L + +E+++
Sbjct: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
Query: 890 KEQIRTQ-QPVERQAKFAD-------VAVNT---DEDWANLHSVVVDRMSYDAEVEKNKR 938
+E++ T Q +E K AD V N DE+ L + + + AE E +++
Sbjct: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRK 125
Query: 939 LMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ +L + DL+ T + + A K ++ ++E + L+ +A+ E+ Q+ +
Sbjct: 126 YEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
Query: 999 DEECETCAEYLKQREEQCKRLKEAKIALE-IVDKLSNQKVALEKQIESLSN 1048
+EE + + LK+ E + + + + LE +D L + + ++ LSN
Sbjct: 186 EEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSN 236
Score = 44.4 bits (100), Expect = 0.002
Identities = 47/230 (20%), Positives = 104/230 (45%), Gaps = 15/230 (6%)
Query: 803 DENRDLGENPKLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCA 862
D+ + E + + +R +++EV+ L R+ ++ELD +ER T
Sbjct: 22 DDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER-------LATAL 74
Query: 863 EYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANL-HS 921
+ L+E ++ ++ +E + +E++ Q+ ++AK +A D + +
Sbjct: 75 QKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK--HIAEEADRKYEEVARK 132
Query: 922 VVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKEL 981
+V+ + E+ + EL + +++ N + ++ EKY++K+ ++E + K L
Sbjct: 133 LVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKIL 192
Query: 982 EDCKAELE---ELKQR-YKELDEECETCAEYLKQREEQCKRL-KEAKIAL 1026
D E E E +R +L++ + E L + E+ + L E K+ L
Sbjct: 193 TDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTL 242
Score = 33.5 bits (73), Expect = 4.3
Identities = 45/222 (20%), Positives = 90/222 (40%), Gaps = 17/222 (7%)
Query: 245 LQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKR 304
LQ E++ R ++ + S+ ++L E + E+L + +A K E +R
Sbjct: 31 LQREVEGERRAREQAEAEVASLNRRIQLVEEELDR-AQERLATALQKLEEAEKAADESER 89
Query: 305 NLNSLSEQLINNESKKSKDHIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLD 364
+ + + + +E K I + K++ +A+ + ++++ DL+
Sbjct: 90 GMKVIENRALKDEEKMELQEI-QLKEAKHIAEEADRKYEEVARKLVIIEG-------DLE 141
Query: 365 EILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTI 424
E+ + +E ELK+V L SL +Q EK + QKE +E +
Sbjct: 142 RTEERAELAESKCSELEEELKNVTNNLKSLEAQ-AEKYS-------QKEDKYEEEIKILT 193
Query: 425 DIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPAHKKIT 466
D +K+ E + KL K D+ L L ++ ++
Sbjct: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
>AL589649-3|CAH71820.1| 1213|Homo sapiens filamin A interacting
protein 1 protein.
Length = 1213
Score = 58.4 bits (135), Expect = 1e-07
Identities = 96/406 (23%), Positives = 177/406 (43%), Gaps = 43/406 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E E N L+K EL +++++ + +G+ N L + +L + + LEME KD+
Sbjct: 343 EELEETNKNLQKAEEELQELRDKIA--KGECGNSSLMAEVENL---RKRVLEMEG--KDE 395
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
EI + KK LQEE L + E + L K + +L+K E ++ +
Sbjct: 396 EITKTESQCRELRKK---LQEEEHHSKELRL----EVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 185 LEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+L +N + K K++ + ++ ++ ++ L ++ L K S+ D T + +
Sbjct: 449 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS-ESRLEKAELSLKDDLTKLKSFTV- 506
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
L E E K+ + + ++ E MD+ EKL E ++ K M E
Sbjct: 507 MLVDERKNMMEKIKQEERKVDGLNKNFKV-EQGKVMDVTEKLIEESKKLLKLKSEMEEKV 565
Query: 304 RNLNSLSEQLI---NNESKKSKD---HIDRYKDSLLAVLDAEFGTT---SLDVFEILM-- 352
NL ++LI +E +KS + +D K L + + E T S E+
Sbjct: 566 YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE 625
Query: 353 DNIINKYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
DN I + ++++ + L++ V+GDL + E + +K + +++ N L
Sbjct: 626 DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-------EQDKANFLS 678
Query: 410 IQKERI-HEISSAVTI---DIVKKENELKEILTKECLKLSKLKIDI 451
Q E I H+I+ I ++V +E EL+ E K LK ++
Sbjct: 679 QQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 724
Score = 57.6 bits (133), Expect = 2e-07
Identities = 63/315 (20%), Positives = 136/315 (43%), Gaps = 27/315 (8%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KL + ++ ++ S S+ +++LL + + + R+ + +E L ++
Sbjct: 274 KLREEEEKLKAITSKSKED--RQKLLKLEVDFEHKASRFSQEHEEMNA---KLANQESHN 328
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE--------DWANLHSVVV 924
+L+ + + L Q++ L+E + Q E + + + E + NL V+
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 388
Query: 925 DRMSYDAEVEKN----KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ D E+ K + L K ++E + ++L+ V K+QK M + K ++ F + E
Sbjct: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---------IVDK 1031
LE+ K K+L E E +K+ E RL++A+++L+ V
Sbjct: 449 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVML 508
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK-KMNAKLITI 1090
+ +K +EK + N V G + +++ + K+ KLK +M K+ +
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
Query: 1091 CKKRGKTGANRENED 1105
++R + ++E+
Sbjct: 569 TRERDELIGKLKSEE 583
Score = 56.4 bits (130), Expect = 5e-07
Identities = 99/483 (20%), Positives = 214/483 (44%), Gaps = 38/483 (7%)
Query: 280 DLDEKLGENNEFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRY-----KDSLL 333
DL +KL E E + KA+ S E ++ L L + S+ S++H + ++S
Sbjct: 270 DLTQKLREEEE-KLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 328
Query: 334 AVLDAEFGTTSLDVFEILMDNI-INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
L + + + E+ N + K + +L E+ +K K + + +E++++ +++
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 388
Query: 393 SL---NSQLIEKENACNILR--IQKERIHEISSAVTIDIVKKE----NELKEILTK---E 440
+ + ++ + E+ C LR +Q+E H + ++ ++K +L+E +K E
Sbjct: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAV 500
C +L L ++ ++L +DL ++ + + + E S + +EK +L L+ K +
Sbjct: 449 CTQLH-LNLEKEKNLTKDLLNELEVV---KSRVKELECSES--RLEKAELSLKDDLTK-L 501
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL-----NLIKILSE 555
+ +++ +V L++ K+ + KV + L L+K+ SE
Sbjct: 502 KSFTVMLVDERKNMMEKIKQEERKVDGLNKNF-KVEQGKVMDVTEKLIEESKKLLKLKSE 560
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ + + +E + L ++ K +EL +++ LK+ + ++ + ITR + + SE
Sbjct: 561 MEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE 620
Query: 616 LE-RSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLA--LKEQ 671
L IK+ E++++K + E K EQ+ A L +Q
Sbjct: 621 LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQ 680
Query: 672 CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-ETKLNELTNKYEA 730
EE ++ + K + E + R RL++ D K ++ + K++EL NK +
Sbjct: 681 LEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQ 740
Query: 731 LKR 733
L +
Sbjct: 741 LSQ 743
Score = 56.0 bits (129), Expect = 7e-07
Identities = 118/600 (19%), Positives = 242/600 (40%), Gaps = 76/600 (12%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+E + L +EL KL VDE ++ + + S+++ L + + EEK+ +++
Sbjct: 227 KENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAIT 286
Query: 576 EKD----NKLTEL-------VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
K KL +L S + EE N+ + + R+ + L + + ++
Sbjct: 287 SKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE 346
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR---DCSR 681
+ L K + ++ E ++L ++ L ++ + EE T+ C
Sbjct: 347 ETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRE 406
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L ++ E ++ + +LQK++ E +KL +E T + L+++ + KD
Sbjct: 407 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN-LTKD 465
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L + E V + + E R+ + E ++ + T
Sbjct: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLT-----------------KLKSFTVML 508
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
DE +++ E K ++ ++ + +V + E+L+ ++L LK +
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME------ 562
Query: 859 ETCAEYLQERDEQCARLKKEK---LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDED 915
E +ERDE +LK E+ L V LK+++ + VER ++
Sbjct: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER-----EITRGRSRK 617
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+ L E K K L IE L+ + Q L+ + K ++Y + +++F
Sbjct: 618 GSELTC---------PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFR 668
Query: 976 AKRKELEDCKAELEELKQRY--KELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
++ + +LEE+K + + E+ E ++ + R RL+EAK L
Sbjct: 669 TEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHR--FRLEEAKSR-----DLK 721
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ AL+++I L N S + V +++Q + M+E K K M +++ + K+
Sbjct: 722 AEVQALKEKIHELMNKEDQLSQLQV--DYSVLQQR----FMEEENKNKNMGQEVLNLTKE 775
Score = 45.2 bits (102), Expect = 0.001
Identities = 102/535 (19%), Positives = 214/535 (40%), Gaps = 39/535 (7%)
Query: 400 EKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK---ECLKLSKLKIDIPRD-- 454
+ ++ N+L ++ER+ ++ +KE E + L K E +KL + + +
Sbjct: 196 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQ 255
Query: 455 --LDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
++Q +K+ L L + E ++ E ++ L+LE
Sbjct: 256 MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHE 315
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+ +E+HN + L +L L + + N NL K EE+ L+ IAK E
Sbjct: 316 EMNAKLAN--QESHN--RQLRLKLVGLTQRIEELEETNKNLQK-AEEELQELRDKIAKGE 370
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELERSCQVIKQ 625
SL + L + V + G EE +S + + E+E + EL + +++
Sbjct: 371 CGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQK 430
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE-I 684
EL+K++ + K LL + +K + +E SRLE
Sbjct: 431 RMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKA 490
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK-RDYDAAVKDLE 743
+ + ++++ +M + ++ +K+ ++E K++ L ++ + + D K +E
Sbjct: 491 ELSLKDDLTKLKSFTVMLVDERKNMMEKI-KQEERKVDGLNKNFKVEQGKVMDVTEKLIE 549
Query: 744 SSR----------EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
S+ E V LT ++D + G++ + E + +E + +V
Sbjct: 550 ESKKLLKLKSEMEEKVYNLTRERDELIGKL-KSEEEKSSELSCSVDLLKKRLDGIEEVER 608
Query: 794 XXXXXXTFGDENRDLGENPKLDD---SPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
+ E+ K+ + +R + EV ++ L+ + E D L+++
Sbjct: 609 EITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEV--VEGDLMKTEDEYDQLEQK 666
Query: 851 YKELDDECETCAEYLQERDEQCARLKK-EKLSLEQQVSNLKEQIRTQQPVERQAK 904
++ D+ ++ L+E Q A+ K EK + Q + L+ + R ++ R K
Sbjct: 667 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 721
>AL589649-1|CAH71818.1| 1114|Homo sapiens filamin A interacting
protein 1 protein.
Length = 1114
Score = 58.4 bits (135), Expect = 1e-07
Identities = 96/406 (23%), Positives = 177/406 (43%), Gaps = 43/406 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E E N L+K EL +++++ + +G+ N L + +L + + LEME KD+
Sbjct: 244 EELEETNKNLQKAEEELQELRDKIA--KGECGNSSLMAEVENL---RKRVLEMEG--KDE 296
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
EI + KK LQEE L + E + L K + +L+K E ++ +
Sbjct: 297 EITKTESQCRELRKK---LQEEEHHSKELRL----EVEKLQKRMSELEKLEEAFSKSKSE 349
Query: 185 LEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+L +N + K K++ + ++ ++ ++ L ++ L K S+ D T + +
Sbjct: 350 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS-ESRLEKAELSLKDDLTKLKSFTV- 407
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
L E E K+ + + ++ E MD+ EKL E ++ K M E
Sbjct: 408 MLVDERKNMMEKIKQEERKVDGLNKNFKV-EQGKVMDVTEKLIEESKKLLKLKSEMEEKV 466
Query: 304 RNLNSLSEQLI---NNESKKSKD---HIDRYKDSLLAVLDAEFGTT---SLDVFEILM-- 352
NL ++LI +E +KS + +D K L + + E T S E+
Sbjct: 467 YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE 526
Query: 353 DNIINKYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
DN I + ++++ + L++ V+GDL + E + +K + +++ N L
Sbjct: 527 DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-------EQDKANFLS 579
Query: 410 IQKERI-HEISSAVTI---DIVKKENELKEILTKECLKLSKLKIDI 451
Q E I H+I+ I ++V +E EL+ E K LK ++
Sbjct: 580 QQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 625
Score = 57.6 bits (133), Expect = 2e-07
Identities = 63/315 (20%), Positives = 136/315 (43%), Gaps = 27/315 (8%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KL + ++ ++ S S+ +++LL + + + R+ + +E L ++
Sbjct: 175 KLREEEEKLKAITSKSKED--RQKLLKLEVDFEHKASRFSQEHEEMNA---KLANQESHN 229
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE--------DWANLHSVVV 924
+L+ + + L Q++ L+E + Q E + + + E + NL V+
Sbjct: 230 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 289
Query: 925 DRMSYDAEVEKN----KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ D E+ K + L K ++E + ++L+ V K+QK M + K ++ F + E
Sbjct: 290 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 349
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---------IVDK 1031
LE+ K K+L E E +K+ E RL++A+++L+ V
Sbjct: 350 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVML 409
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK-KMNAKLITI 1090
+ +K +EK + N V G + +++ + K+ KLK +M K+ +
Sbjct: 410 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 469
Query: 1091 CKKRGKTGANRENED 1105
++R + ++E+
Sbjct: 470 TRERDELIGKLKSEE 484
Score = 56.4 bits (130), Expect = 5e-07
Identities = 99/483 (20%), Positives = 214/483 (44%), Gaps = 38/483 (7%)
Query: 280 DLDEKLGENNEFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRY-----KDSLL 333
DL +KL E E + KA+ S E ++ L L + S+ S++H + ++S
Sbjct: 171 DLTQKLREEEE-KLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 229
Query: 334 AVLDAEFGTTSLDVFEILMDNI-INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
L + + + E+ N + K + +L E+ +K K + + +E++++ +++
Sbjct: 230 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 289
Query: 393 SL---NSQLIEKENACNILR--IQKERIHEISSAVTIDIVKKE----NELKEILTK---E 440
+ + ++ + E+ C LR +Q+E H + ++ ++K +L+E +K E
Sbjct: 290 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 349
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAV 500
C +L L ++ ++L +DL ++ + + + E S + +EK +L L+ K +
Sbjct: 350 CTQLH-LNLEKEKNLTKDLLNELEVV---KSRVKELECSES--RLEKAELSLKDDLTK-L 402
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL-----NLIKILSE 555
+ +++ +V L++ K+ + KV + L L+K+ SE
Sbjct: 403 KSFTVMLVDERKNMMEKIKQEERKVDGLNKNF-KVEQGKVMDVTEKLIEESKKLLKLKSE 461
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ + + +E + L ++ K +EL +++ LK+ + ++ + ITR + + SE
Sbjct: 462 MEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE 521
Query: 616 LE-RSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLA--LKEQ 671
L IK+ E++++K + E K EQ+ A L +Q
Sbjct: 522 LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQ 581
Query: 672 CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-ETKLNELTNKYEA 730
EE ++ + K + E + R RL++ D K ++ + K++EL NK +
Sbjct: 582 LEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQ 641
Query: 731 LKR 733
L +
Sbjct: 642 LSQ 644
Score = 56.0 bits (129), Expect = 7e-07
Identities = 118/600 (19%), Positives = 242/600 (40%), Gaps = 76/600 (12%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+E + L +EL KL VDE ++ + + S+++ L + + EEK+ +++
Sbjct: 128 KENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAIT 187
Query: 576 EKD----NKLTEL-------VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
K KL +L S + EE N+ + + R+ + L + + ++
Sbjct: 188 SKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE 247
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR---DCSR 681
+ L K + ++ E ++L ++ L ++ + EE T+ C
Sbjct: 248 ETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRE 307
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L ++ E ++ + +LQK++ E +KL +E T + L+++ + KD
Sbjct: 308 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN-LTKD 366
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L + E V + + E R+ + E ++ + T
Sbjct: 367 LLNELEVVKSRVKELECSESRLEKAELSLKDDLT-----------------KLKSFTVML 409
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
DE +++ E K ++ ++ + +V + E+L+ ++L LK +
Sbjct: 410 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME------ 463
Query: 859 ETCAEYLQERDEQCARLKKEK---LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDED 915
E +ERDE +LK E+ L V LK+++ + VER ++
Sbjct: 464 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER-----EITRGRSRK 518
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+ L E K K L IE L+ + Q L+ + K ++Y + +++F
Sbjct: 519 GSELTC---------PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFR 569
Query: 976 AKRKELEDCKAELEELKQRY--KELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
++ + +LEE+K + + E+ E ++ + R RL+EAK L
Sbjct: 570 TEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHR--FRLEEAKSR-----DLK 622
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ AL+++I L N S + V +++Q + M+E K K M +++ + K+
Sbjct: 623 AEVQALKEKIHELMNKEDQLSQLQV--DYSVLQQR----FMEEENKNKNMGQEVLNLTKE 676
Score = 45.2 bits (102), Expect = 0.001
Identities = 102/535 (19%), Positives = 214/535 (40%), Gaps = 39/535 (7%)
Query: 400 EKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK---ECLKLSKLKIDIPRD-- 454
+ ++ N+L ++ER+ ++ +KE E + L K E +KL + + +
Sbjct: 97 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQ 156
Query: 455 --LDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
++Q +K+ L L + E ++ E ++ L+LE
Sbjct: 157 MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHE 216
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+ +E+HN + L +L L + + N NL K EE+ L+ IAK E
Sbjct: 217 EMNAKLAN--QESHN--RQLRLKLVGLTQRIEELEETNKNLQK-AEEELQELRDKIAKGE 271
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELERSCQVIKQ 625
SL + L + V + G EE +S + + E+E + EL + +++
Sbjct: 272 CGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQK 331
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE-I 684
EL+K++ + K LL + +K + +E SRLE
Sbjct: 332 RMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKA 391
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK-RDYDAAVKDLE 743
+ + ++++ +M + ++ +K+ ++E K++ L ++ + + D K +E
Sbjct: 392 ELSLKDDLTKLKSFTVMLVDERKNMMEKI-KQEERKVDGLNKNFKVEQGKVMDVTEKLIE 450
Query: 744 SSR----------EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
S+ E V LT ++D + G++ + E + +E + +V
Sbjct: 451 ESKKLLKLKSEMEEKVYNLTRERDELIGKL-KSEEEKSSELSCSVDLLKKRLDGIEEVER 509
Query: 794 XXXXXXTFGDENRDLGENPKLDD---SPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
+ E+ K+ + +R + EV ++ L+ + E D L+++
Sbjct: 510 EITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEV--VEGDLMKTEDEYDQLEQK 567
Query: 851 YKELDDECETCAEYLQERDEQCARLKK-EKLSLEQQVSNLKEQIRTQQPVERQAK 904
++ D+ ++ L+E Q A+ K EK + Q + L+ + R ++ R K
Sbjct: 568 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 622
>AL445465-2|CAH73615.1| 1213|Homo sapiens filamin A interacting
protein 1 protein.
Length = 1213
Score = 58.4 bits (135), Expect = 1e-07
Identities = 96/406 (23%), Positives = 177/406 (43%), Gaps = 43/406 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E E N L+K EL +++++ + +G+ N L + +L + + LEME KD+
Sbjct: 343 EELEETNKNLQKAEEELQELRDKIA--KGECGNSSLMAEVENL---RKRVLEMEG--KDE 395
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
EI + KK LQEE L + E + L K + +L+K E ++ +
Sbjct: 396 EITKTESQCRELRKK---LQEEEHHSKELRL----EVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 185 LEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+L +N + K K++ + ++ ++ ++ L ++ L K S+ D T + +
Sbjct: 449 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS-ESRLEKAELSLKDDLTKLKSFTV- 506
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
L E E K+ + + ++ E MD+ EKL E ++ K M E
Sbjct: 507 MLVDERKNMMEKIKQEERKVDGLNKNFKV-EQGKVMDVTEKLIEESKKLLKLKSEMEEKV 565
Query: 304 RNLNSLSEQLI---NNESKKSKD---HIDRYKDSLLAVLDAEFGTT---SLDVFEILM-- 352
NL ++LI +E +KS + +D K L + + E T S E+
Sbjct: 566 YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE 625
Query: 353 DNIINKYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
DN I + ++++ + L++ V+GDL + E + +K + +++ N L
Sbjct: 626 DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-------EQDKANFLS 678
Query: 410 IQKERI-HEISSAVTI---DIVKKENELKEILTKECLKLSKLKIDI 451
Q E I H+I+ I ++V +E EL+ E K LK ++
Sbjct: 679 QQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 724
Score = 57.6 bits (133), Expect = 2e-07
Identities = 63/315 (20%), Positives = 136/315 (43%), Gaps = 27/315 (8%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KL + ++ ++ S S+ +++LL + + + R+ + +E L ++
Sbjct: 274 KLREEEEKLKAITSKSKED--RQKLLKLEVDFEHKASRFSQEHEEMNA---KLANQESHN 328
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE--------DWANLHSVVV 924
+L+ + + L Q++ L+E + Q E + + + E + NL V+
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 388
Query: 925 DRMSYDAEVEKN----KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ D E+ K + L K ++E + ++L+ V K+QK M + K ++ F + E
Sbjct: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---------IVDK 1031
LE+ K K+L E E +K+ E RL++A+++L+ V
Sbjct: 449 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVML 508
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK-KMNAKLITI 1090
+ +K +EK + N V G + +++ + K+ KLK +M K+ +
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
Query: 1091 CKKRGKTGANRENED 1105
++R + ++E+
Sbjct: 569 TRERDELIGKLKSEE 583
Score = 56.4 bits (130), Expect = 5e-07
Identities = 99/483 (20%), Positives = 214/483 (44%), Gaps = 38/483 (7%)
Query: 280 DLDEKLGENNEFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRY-----KDSLL 333
DL +KL E E + KA+ S E ++ L L + S+ S++H + ++S
Sbjct: 270 DLTQKLREEEE-KLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 328
Query: 334 AVLDAEFGTTSLDVFEILMDNI-INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
L + + + E+ N + K + +L E+ +K K + + +E++++ +++
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 388
Query: 393 SL---NSQLIEKENACNILR--IQKERIHEISSAVTIDIVKKE----NELKEILTK---E 440
+ + ++ + E+ C LR +Q+E H + ++ ++K +L+E +K E
Sbjct: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAV 500
C +L L ++ ++L +DL ++ + + + E S + +EK +L L+ K +
Sbjct: 449 CTQLH-LNLEKEKNLTKDLLNELEVV---KSRVKELECSES--RLEKAELSLKDDLTK-L 501
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL-----NLIKILSE 555
+ +++ +V L++ K+ + KV + L L+K+ SE
Sbjct: 502 KSFTVMLVDERKNMMEKIKQEERKVDGLNKNF-KVEQGKVMDVTEKLIEESKKLLKLKSE 560
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ + + +E + L ++ K +EL +++ LK+ + ++ + ITR + + SE
Sbjct: 561 MEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE 620
Query: 616 LE-RSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLA--LKEQ 671
L IK+ E++++K + E K EQ+ A L +Q
Sbjct: 621 LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQ 680
Query: 672 CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-ETKLNELTNKYEA 730
EE ++ + K + E + R RL++ D K ++ + K++EL NK +
Sbjct: 681 LEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQ 740
Query: 731 LKR 733
L +
Sbjct: 741 LSQ 743
Score = 56.0 bits (129), Expect = 7e-07
Identities = 118/600 (19%), Positives = 242/600 (40%), Gaps = 76/600 (12%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+E + L +EL KL VDE ++ + + S+++ L + + EEK+ +++
Sbjct: 227 KENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAIT 286
Query: 576 EKD----NKLTEL-------VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
K KL +L S + EE N+ + + R+ + L + + ++
Sbjct: 287 SKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE 346
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR---DCSR 681
+ L K + ++ E ++L ++ L ++ + EE T+ C
Sbjct: 347 ETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRE 406
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L ++ E ++ + +LQK++ E +KL +E T + L+++ + KD
Sbjct: 407 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN-LTKD 465
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L + E V + + E R+ + E ++ + T
Sbjct: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLT-----------------KLKSFTVML 508
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
DE +++ E K ++ ++ + +V + E+L+ ++L LK +
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME------ 562
Query: 859 ETCAEYLQERDEQCARLKKEK---LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDED 915
E +ERDE +LK E+ L V LK+++ + VER ++
Sbjct: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER-----EITRGRSRK 617
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+ L E K K L IE L+ + Q L+ + K ++Y + +++F
Sbjct: 618 GSELTC---------PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFR 668
Query: 976 AKRKELEDCKAELEELKQRY--KELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
++ + +LEE+K + + E+ E ++ + R RL+EAK L
Sbjct: 669 TEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHR--FRLEEAKSR-----DLK 721
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ AL+++I L N S + V +++Q + M+E K K M +++ + K+
Sbjct: 722 AEVQALKEKIHELMNKEDQLSQLQV--DYSVLQQR----FMEEENKNKNMGQEVLNLTKE 775
Score = 45.2 bits (102), Expect = 0.001
Identities = 102/535 (19%), Positives = 214/535 (40%), Gaps = 39/535 (7%)
Query: 400 EKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK---ECLKLSKLKIDIPRD-- 454
+ ++ N+L ++ER+ ++ +KE E + L K E +KL + + +
Sbjct: 196 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQ 255
Query: 455 --LDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
++Q +K+ L L + E ++ E ++ L+LE
Sbjct: 256 MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHE 315
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+ +E+HN + L +L L + + N NL K EE+ L+ IAK E
Sbjct: 316 EMNAKLAN--QESHN--RQLRLKLVGLTQRIEELEETNKNLQK-AEEELQELRDKIAKGE 370
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELERSCQVIKQ 625
SL + L + V + G EE +S + + E+E + EL + +++
Sbjct: 371 CGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQK 430
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE-I 684
EL+K++ + K LL + +K + +E SRLE
Sbjct: 431 RMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKA 490
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK-RDYDAAVKDLE 743
+ + ++++ +M + ++ +K+ ++E K++ L ++ + + D K +E
Sbjct: 491 ELSLKDDLTKLKSFTVMLVDERKNMMEKI-KQEERKVDGLNKNFKVEQGKVMDVTEKLIE 549
Query: 744 SSR----------EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
S+ E V LT ++D + G++ + E + +E + +V
Sbjct: 550 ESKKLLKLKSEMEEKVYNLTRERDELIGKL-KSEEEKSSELSCSVDLLKKRLDGIEEVER 608
Query: 794 XXXXXXTFGDENRDLGENPKLDD---SPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
+ E+ K+ + +R + EV ++ L+ + E D L+++
Sbjct: 609 EITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEV--VEGDLMKTEDEYDQLEQK 666
Query: 851 YKELDDECETCAEYLQERDEQCARLKK-EKLSLEQQVSNLKEQIRTQQPVERQAK 904
++ D+ ++ L+E Q A+ K EK + Q + L+ + R ++ R K
Sbjct: 667 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 721
>AL445465-1|CAH73614.1| 1114|Homo sapiens filamin A interacting
protein 1 protein.
Length = 1114
Score = 58.4 bits (135), Expect = 1e-07
Identities = 96/406 (23%), Positives = 177/406 (43%), Gaps = 43/406 (10%)
Query: 65 ESSNEINLKLEKLSGELFDIKEQKSALEGKYQNLILETQTRDLLMSQIKSLEMENLTKDK 124
E E N L+K EL +++++ + +G+ N L + +L + + LEME KD+
Sbjct: 244 EELEETNKNLQKAEEELQELRDKIA--KGECGNSSLMAEVENL---RKRVLEMEG--KDE 296
Query: 125 EIKNLTDSLKTKSKKINELQEENDTLSNLIMENVTESDNLNKEVDDLKKNNECLTQKCID 184
EI + KK LQEE L + E + L K + +L+K E ++ +
Sbjct: 297 EITKTESQCRELRKK---LQEEEHHSKELRL----EVEKLQKRMSELEKLEEAFSKSKSE 349
Query: 185 LEKL-VNESENKIGPKNICAQCKLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKIC 243
+L +N + K K++ + ++ ++ ++ L ++ L K S+ D T + +
Sbjct: 350 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS-ESRLEKAELSLKDDLTKLKSFTV- 407
Query: 244 TLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIK 303
L E E K+ + + ++ E MD+ EKL E ++ K M E
Sbjct: 408 MLVDERKNMMEKIKQEERKVDGLNKNFKV-EQGKVMDVTEKLIEESKKLLKLKSEMEEKV 466
Query: 304 RNLNSLSEQLI---NNESKKSKD---HIDRYKDSLLAVLDAEFGTT---SLDVFEILM-- 352
NL ++LI +E +KS + +D K L + + E T S E+
Sbjct: 467 YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPE 526
Query: 353 DNIINKYQIDLDEI---LEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILR 409
DN I + ++++ + L++ V+GDL + E + +K + +++ N L
Sbjct: 527 DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-------EQDKANFLS 579
Query: 410 IQKERI-HEISSAVTI---DIVKKENELKEILTKECLKLSKLKIDI 451
Q E I H+I+ I ++V +E EL+ E K LK ++
Sbjct: 580 QQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 625
Score = 57.6 bits (133), Expect = 2e-07
Identities = 63/315 (20%), Positives = 136/315 (43%), Gaps = 27/315 (8%)
Query: 813 KLDDSPKRSISVISDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQC 872
KL + ++ ++ S S+ +++LL + + + R+ + +E L ++
Sbjct: 175 KLREEEEKLKAITSKSKED--RQKLLKLEVDFEHKASRFSQEHEEMNA---KLANQESHN 229
Query: 873 ARLKKEKLSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDE--------DWANLHSVVV 924
+L+ + + L Q++ L+E + Q E + + + E + NL V+
Sbjct: 230 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 289
Query: 925 DRMSYDAEVEKN----KRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKE 980
+ D E+ K + L K ++E + ++L+ V K+QK M + K ++ F + E
Sbjct: 290 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 349
Query: 981 LEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKRLKEAKIALE---------IVDK 1031
LE+ K K+L E E +K+ E RL++A+++L+ V
Sbjct: 350 CTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVML 409
Query: 1032 LSNQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLK-KMNAKLITI 1090
+ +K +EK + N V G + +++ + K+ KLK +M K+ +
Sbjct: 410 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 469
Query: 1091 CKKRGKTGANRENED 1105
++R + ++E+
Sbjct: 470 TRERDELIGKLKSEE 484
Score = 56.4 bits (130), Expect = 5e-07
Identities = 99/483 (20%), Positives = 214/483 (44%), Gaps = 38/483 (7%)
Query: 280 DLDEKLGENNEFETKAVKVMS-EIKRNLNSLSEQLINNESKKSKDHIDRY-----KDSLL 333
DL +KL E E + KA+ S E ++ L L + S+ S++H + ++S
Sbjct: 171 DLTQKLREEEE-KLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 229
Query: 334 AVLDAEFGTTSLDVFEILMDNI-INKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLA 392
L + + + E+ N + K + +L E+ +K K + + +E++++ +++
Sbjct: 230 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 289
Query: 393 SL---NSQLIEKENACNILR--IQKERIHEISSAVTIDIVKKE----NELKEILTK---E 440
+ + ++ + E+ C LR +Q+E H + ++ ++K +L+E +K E
Sbjct: 290 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 349
Query: 441 CLKLSKLKIDIPRDLDQDLPAHKKITILFDALITQYELSRTDYEIEKEKLRLETGTAKAV 500
C +L L ++ ++L +DL ++ + + + E S + +EK +L L+ K +
Sbjct: 350 CTQLH-LNLEKEKNLTKDLLNELEVV---KSRVKELECSES--RLEKAELSLKDDLTK-L 402
Query: 501 XXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANL-----NLIKILSE 555
+ +++ +V L++ K+ + KV + L L+K+ SE
Sbjct: 403 KSFTVMLVDERKNMMEKIKQEERKVDGLNKNF-KVEQGKVMDVTEKLIEESKKLLKLKSE 461
Query: 556 EIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITREKETQASE 615
+ + + +E + L ++ K +EL +++ LK+ + ++ + ITR + + SE
Sbjct: 462 MEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE 521
Query: 616 LE-RSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXD-EAKSLLEQNLA--LKEQ 671
L IK+ E++++K + E K EQ+ A L +Q
Sbjct: 522 LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQ 581
Query: 672 CEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEK-ETKLNELTNKYEA 730
EE ++ + K + E + R RL++ D K ++ + K++EL NK +
Sbjct: 582 LEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQ 641
Query: 731 LKR 733
L +
Sbjct: 642 LSQ 644
Score = 56.0 bits (129), Expect = 7e-07
Identities = 118/600 (19%), Positives = 242/600 (40%), Gaps = 76/600 (12%)
Query: 519 EEAHNEVKSLHEELTKLYKSK---VDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLS 575
+E + L +EL KL VDE ++ + + S+++ L + + EEK+ +++
Sbjct: 128 KENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAIT 187
Query: 576 EKD----NKLTEL-------VSTINGLKEENNSLKSLNDVITREKETQASELERSCQVIK 624
K KL +L S + EE N+ + + R+ + L + + ++
Sbjct: 188 SKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE 247
Query: 625 QNGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTR---DCSR 681
+ L K + ++ E ++L ++ L ++ + EE T+ C
Sbjct: 248 ETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRE 307
Query: 682 LEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALKRDYDAAVKD 741
L ++ E ++ + +LQK++ E +KL +E T + L+++ + KD
Sbjct: 308 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN-LTKD 366
Query: 742 LESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTF 801
L + E V + + E R+ + E ++ + T
Sbjct: 367 LLNELEVVKSRVKELECSESRLEKAELSLKDDLT-----------------KLKSFTVML 409
Query: 802 GDENRDLGENPKLDDSPKRSIS---VISDSEVSQLKERLLSCQQELDDLKERYKELDDEC 858
DE +++ E K ++ ++ + +V + E+L+ ++L LK +
Sbjct: 410 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME------ 463
Query: 859 ETCAEYLQERDEQCARLKKEK---LSLEQQVSNLKEQIRTQQPVERQAKFADVAVNTDED 915
E +ERDE +LK E+ L V LK+++ + VER ++
Sbjct: 464 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER-----EITRGRSRK 518
Query: 916 WANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVTKMQKAMEKYTKKDKEFE 975
+ L E K K L IE L+ + Q L+ + K ++Y + +++F
Sbjct: 519 GSELTC---------PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFR 569
Query: 976 AKRKELEDCKAELEELKQRY--KELDEECETCAEYLKQREEQCKRLKEAKIALEIVDKLS 1033
++ + +LEE+K + + E+ E ++ + R RL+EAK L
Sbjct: 570 TEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHR--FRLEEAKSR-----DLK 622
Query: 1034 NQKVALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKENQKLKKMNAKLITICKK 1093
+ AL+++I L N S + V +++Q + M+E K K M +++ + K+
Sbjct: 623 AEVQALKEKIHELMNKEDQLSQLQV--DYSVLQQR----FMEEENKNKNMGQEVLNLTKE 676
Score = 45.2 bits (102), Expect = 0.001
Identities = 102/535 (19%), Positives = 214/535 (40%), Gaps = 39/535 (7%)
Query: 400 EKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTK---ECLKLSKLKIDIPRD-- 454
+ ++ N+L ++ER+ ++ +KE E + L K E +KL + + +
Sbjct: 97 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQ 156
Query: 455 --LDQDLPAHKKITILFDALITQYE----LSRTDYEIEKEKLRLETGTAKAVXXXXXXXX 508
++Q +K+ L L + E ++ E ++ L+LE
Sbjct: 157 MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHE 216
Query: 509 XXXXXXFDTLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKNE 568
+ +E+HN + L +L L + + N NL K EE+ L+ IAK E
Sbjct: 217 EMNAKLAN--QESHN--RQLRLKLVGLTQRIEELEETNKNLQK-AEEELQELRDKIAKGE 271
Query: 569 EKMLSLSEKDNKLTELVSTINGLKEENNSLKSLNDVITR---EKETQASELERSCQVIKQ 625
SL + L + V + G EE +S + + E+E + EL + +++
Sbjct: 272 CGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQK 331
Query: 626 NGFELDKMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEKTRDCSRLE-I 684
EL+K++ + K LL + +K + +E SRLE
Sbjct: 332 RMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKA 391
Query: 685 NIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKETKLNELTNKYEALK-RDYDAAVKDLE 743
+ + ++++ +M + ++ +K+ ++E K++ L ++ + + D K +E
Sbjct: 392 ELSLKDDLTKLKSFTVMLVDERKNMMEKI-KQEERKVDGLNKNFKVEQGKVMDVTEKLIE 450
Query: 744 SSR----------EAVNQLTTQKDLVEGRIAELESDIRTEQTATVXXXXXXXXXXXXXXX 793
S+ E V LT ++D + G++ + E + +E + +V
Sbjct: 451 ESKKLLKLKSEMEEKVYNLTRERDELIGKL-KSEEEKSSELSCSVDLLKKRLDGIEEVER 509
Query: 794 XXXXXXTFGDENRDLGENPKLDD---SPKRSISVISDSEVSQLKERLLSCQQELDDLKER 850
+ E+ K+ + +R + EV ++ L+ + E D L+++
Sbjct: 510 EITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEV--VEGDLMKTEDEYDQLEQK 567
Query: 851 YKELDDECETCAEYLQERDEQCARLKK-EKLSLEQQVSNLKEQIRTQQPVERQAK 904
++ D+ ++ L+E Q A+ K EK + Q + L+ + R ++ R K
Sbjct: 568 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 622
>AL365436-2|CAI16590.1| 1203|Homo sapiens cingulin protein.
Length = 1203
Score = 58.4 bits (135), Expect = 1e-07
Identities = 83/405 (20%), Positives = 172/405 (42%), Gaps = 33/405 (8%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+ L + L+ Q EEKT +CSRL+ ++ + A+ N+ + +++ + + + L E
Sbjct: 383 QKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLE 442
Query: 719 TKLNELTNKYEALKRDYDA---AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
T++ EL NK + ++ A +KDL +RE + ++ K VE ++ E ++
Sbjct: 443 TQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLREREL----- 497
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
T + + L + + D+ + + ++E ++
Sbjct: 498 -TALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRS--MQDATQD--HAVLEAERQKMSA 552
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL------ 889
+ Q+EL++ E + E L+ ++ +L+ EK +E+++
Sbjct: 553 LVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQR 612
Query: 890 -KEQIRTQQPVERQAK-FADVAVNTDEDWANL----HSVVVDRMSYDAEVEKNKRLMKTI 943
EQ R RQ + + T E+ L S V D E+EK +++
Sbjct: 613 ELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
Query: 944 ----EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
EL + L+ T+ ++++ E+ +K EA+ L +A +E + +E +
Sbjct: 673 ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEN 732
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALE--IVDKLSNQKVALEKQ 1042
+E L+Q+ ++ + L + A+E + DKL Q++ EKQ
Sbjct: 733 DEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKL--QRLEAEKQ 775
Score = 54.4 bits (125), Expect = 2e-06
Identities = 137/717 (19%), Positives = 280/717 (39%), Gaps = 58/717 (8%)
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L+E E+ +++Q L E + N++L ++ L + E+ + L Q + E+ +
Sbjct: 396 LEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQ---VMELQNK- 451
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDI----PRDLDQDLPAHKKITILFDALITQYEL 478
+ V+ KE+L K+ L+ +L ++ R +Q +++T L AL + E+
Sbjct: 452 -LKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL--KEEV 508
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
+ D E+E + + + T + LE ++ +L L + +
Sbjct: 509 ASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHA-----VLEAERQKMSALVRGLQRELEE 563
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
+E ++ + E++ A K +E + EK+ EL I L+ E
Sbjct: 564 TSEETGHWQSMFQKNKEDLRATK------QELLQLRMEKEEMEEELGEKIEVLQRELEQA 617
Query: 599 K-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE 657
+ S D TR+ E EL R+ + +K+ E + D
Sbjct: 618 RASAGD--TRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI--QNRMIMR--LQKQIQEDDK- 712
+ L EQNL L++ ++ +DC E A + Q R + L++ +E+D+
Sbjct: 676 GRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEF 735
Query: 713 ----LFIEKETK-LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIA--- 764
L +E++ K L + EA++ ++ LE+ ++ + + EG +A
Sbjct: 736 RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
Query: 765 -ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
LE+ + Q +L E +L D ++
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 824 VISDSEVSQLKERLLSCQQELDDLKER-YKELDDECETCAEYLQERDEQCARLKKEKLSL 882
+ K+ L Q +L+D KE+ +E+ D ++ E ++ L + L
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR----L 911
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT 942
+ ++ L++ ++ Q ER D + + S D + K L +
Sbjct: 912 QDEIQRLRQALQASQ-AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
Query: 943 IEELRYKKQDLKNTV----TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ L + + KNTV ++ + ++ + E +R +D + + L+++ K+L
Sbjct: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
Query: 999 ------DEECETCAEYLKQREEQCKRLKEAKIALEIVDK--LSNQKVALEKQIESLS 1047
E + + L Q E Q + L+E ++ E +K L + LE++++ LS
Sbjct: 1031 KTRLASSEGFQKPSASLSQLESQNQLLQE-RLQAEEREKTVLQSTNRKLERKVKELS 1086
Score = 50.8 bits (116), Expect = 3e-05
Identities = 151/843 (17%), Positives = 329/843 (39%), Gaps = 73/843 (8%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD 282
L K+ + S+ ST K Q EL E+ + ++ + LE + + L+
Sbjct: 341 LEKMQPLVMVSSGST---KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLE 397
Query: 283 EKLGENNEFETKAVKVMSEIKRNLNSLSE-QLINNESKKSKDHIDRYKDSLLAVLDAEFG 341
EK E + + + E +++ L + + ++ + + ++ L L G
Sbjct: 398 EKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQG 457
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK 401
E+L+ +++ ++ L+E+LE +V+ L EL ++ +L ++ +
Sbjct: 458 PEPAK--EVLLKDLLETREL-LEEVLEGKQRVEEQLRLRERELTALK---GALKEEVASR 511
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
+ +R Q +R E D + +L E K+S L + R+L++
Sbjct: 512 DQEVEHVRQQYQRDTEQLRRSMQDATQDH----AVLEAERQKMSALVRGLQRELEETSEE 567
Query: 462 HKKITILF-----DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
+F D T+ EL + +EKE++ E G V
Sbjct: 568 TGHWQSMFQKNKEDLRATKQELLQL--RMEKEEMEEELGEKIEVLQRELEQARASAGDTR 625
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN---EEKMLS 573
+E E+ EEL +L + + A + + L +++ L++ + EE+ L
Sbjct: 626 QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQ 685
Query: 574 LSEKDNKLT---ELVSTINGLKEENNSL----KSLNDVITREKETQASELERSC----QV 622
L + +L E S + E ++ ++ + RE + + E R Q
Sbjct: 686 LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQ 745
Query: 623 IKQNGFELD-------KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
+K+ +D +++ + +E SL AL+ + EE
Sbjct: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
Query: 676 TRDCSRLEINIKTHEKTAEI---QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY---- 728
R +RL +T + E Q ++ R + +++E +L +LN+ K
Sbjct: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDS 865
Query: 729 -EALKR------DY-DAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+AL++ DY + A +++ ++ ++ + G ++ L+ +I+ + A
Sbjct: 866 KQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQAS 925
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLS 839
E EN K D R + + + +VS+L+ L
Sbjct: 926 QAERDTARLDKELLAQRLQGLEQE----AENKKRSQDDRARQLKGLEE-KVSRLETELDE 980
Query: 840 CQQELDDLKERYKELDDECETC-AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
+ ++ L +R D+ + E +QER + L+ +K+SLE+Q +LK ++ + +
Sbjct: 981 EKNTVELLTDRVNRGRDQVDQLRTELMQERSAR-QDLECDKISLERQNKDLKTRLASSEG 1039
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ + A ++ ++ + + N++L + ++EL + +D + V
Sbjct: 1040 FQKPS--ASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVN 1097
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
+ + K A ++++++ + E+E L K+ E E E +Q + + K
Sbjct: 1098 DQKDQLSLRVK------ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151
Query: 1019 LKE 1021
L++
Sbjct: 1152 LEK 1154
Score = 34.7 bits (76), Expect = 1.9
Identities = 58/280 (20%), Positives = 120/280 (42%), Gaps = 33/280 (11%)
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
S E L + + L++ + L E +T L+E +Q L++ K LE+Q
Sbjct: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ 843
Query: 886 -------VSNLKEQIR-----TQQPVER-QAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
V L +++ ++Q +++ QA+ D + A+ D + +E
Sbjct: 844 KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKD---WASE 900
Query: 933 VEKN----KRLMKTIEELRYKKQ--DLKNTVTKMQKAM--EKYTKKDKEFEAKRKELEDC 984
EK RL I+ LR Q + ++ K + ++ ++E E K++ +D
Sbjct: 901 AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR 960
Query: 985 KAELEELKQRYK----ELDEE---CETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQK 1036
+L+ L+++ ELDEE E + + + +Q +L+ E L K
Sbjct: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
++LE+Q + L T +++S + +++ Q + +++E
Sbjct: 1021 ISLERQNKDL-KTRLASSEGFQKPSASLSQLESQNQLLQE 1059
Score = 34.3 bits (75), Expect = 2.5
Identities = 72/362 (19%), Positives = 147/362 (40%), Gaps = 33/362 (9%)
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
QNL L+ +T L + + + E L + E QEEND I+
Sbjct: 682 QNLQLQ-KTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRIL 740
Query: 156 ---ENVTESDNL---NKEVDD-LKKNNECLTQKCIDLEKLVN---ESENKIGPKNICAQC 205
+ + E+ L + V+ L+ + L + LE+ +N E E + +
Sbjct: 741 GLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEA 800
Query: 206 KLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
+L+E +G + LNR++ + + ++EL+ E + L
Sbjct: 801 RLEEAQRGLARLGQEQ--QTLNRALEEEGKQREVLR--RGKAELE---EQKRLLDRTVDR 853
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK--D 323
+ LE + L + + +++ KA + +++ +R + + S+ D
Sbjct: 854 LNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQD 913
Query: 324 HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE 383
I R + +L A AE T LD E+L + L++ E + Q D +
Sbjct: 914 EIQRLRQALQAS-QAERDTARLDK-ELLAQRLQG-----LEQEAENKKRSQDDR---ARQ 963
Query: 384 LKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLK 443
LK + EK++ L ++L E++N +L + R + + +++++ + +++ EC K
Sbjct: 964 LKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL---ECDK 1020
Query: 444 LS 445
+S
Sbjct: 1021 IS 1022
>AF263462-1|AAF74498.1| 1203|Homo sapiens cingulin protein.
Length = 1203
Score = 58.4 bits (135), Expect = 1e-07
Identities = 83/405 (20%), Positives = 172/405 (42%), Gaps = 33/405 (8%)
Query: 659 KSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEIQNRMIMRLQKQIQEDDKLFIEKE 718
+ L + L+ Q EEKT +CSRL+ ++ + A+ N+ + +++ + + + L E
Sbjct: 383 QKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLE 442
Query: 719 TKLNELTNKYEALKRDYDA---AVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQT 775
T++ EL NK + ++ A +KDL +RE + ++ K VE ++ E ++
Sbjct: 443 TQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLREREL----- 497
Query: 776 ATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSISVISDSEVSQLKE 835
T + + L + + D+ + + ++E ++
Sbjct: 498 -TALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRS--MQDATQD--HAVLEAERQKMSA 552
Query: 836 RLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQVSNL------ 889
+ Q+EL++ E + E L+ ++ +L+ EK +E+++
Sbjct: 553 LVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQR 612
Query: 890 -KEQIRTQQPVERQAK-FADVAVNTDEDWANL----HSVVVDRMSYDAEVEKNKRLMKTI 943
EQ R RQ + + T E+ L S V D E+EK +++
Sbjct: 613 ELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
Query: 944 ----EELRYKKQDLKNTVTKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELD 999
EL + L+ T+ ++++ E+ +K EA+ L +A +E + +E +
Sbjct: 673 ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEN 732
Query: 1000 EECETCAEYLKQREEQCKRLKEAKIALE--IVDKLSNQKVALEKQ 1042
+E L+Q+ ++ + L + A+E + DKL Q++ EKQ
Sbjct: 733 DEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKL--QRLEAEKQ 775
Score = 54.4 bits (125), Expect = 2e-06
Identities = 137/717 (19%), Positives = 280/717 (39%), Gaps = 58/717 (8%)
Query: 363 LDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAV 422
L+E E+ +++Q L E + N++L ++ L + E+ + L Q + E+ +
Sbjct: 396 LEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQ---VMELQNK- 451
Query: 423 TIDIVKKENELKEILTKECLKLSKLKIDI----PRDLDQDLPAHKKITILFDALITQYEL 478
+ V+ KE+L K+ L+ +L ++ R +Q +++T L AL + E+
Sbjct: 452 -LKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL--KEEV 508
Query: 479 SRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFDTLEEAHNEVKSLHEELTKLYKS 538
+ D E+E + + + T + LE ++ +L L + +
Sbjct: 509 ASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHA-----VLEAERQKMSALVRGLQRELEE 563
Query: 539 KVDENNANLNLIKILSEEIDALKIAIAKNEEKMLSLSEKDNKLTELVSTINGLKEENNSL 598
+E ++ + E++ A K +E + EK+ EL I L+ E
Sbjct: 564 TSEETGHWQSMFQKNKEDLRATK------QELLQLRMEKEEMEEELGEKIEVLQRELEQA 617
Query: 599 K-SLNDVITREKETQASELERSCQVIKQNGFELDKMKADILMXXXXXXXXXXXXXXXXDE 657
+ S D TR+ E EL R+ + +K+ E + D
Sbjct: 618 RASAGD--TRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675
Query: 658 AKSLLEQNLALKEQCEEKTRDCSRLEINIKTHEKTAEI--QNRMIMR--LQKQIQEDDK- 712
+ L EQNL L++ ++ +DC E A + Q R + L++ +E+D+
Sbjct: 676 GRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEF 735
Query: 713 ----LFIEKETK-LNELTNKYEALKRDYDAAVKDLESSREAVNQLTTQKDLVEGRIA--- 764
L +E++ K L + EA++ ++ LE+ ++ + + EG +A
Sbjct: 736 RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
Query: 765 -ELESDIRTEQTATVXXXXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLDDSPKRSIS 823
LE+ + Q +L E +L D ++
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 824 VISDSEVSQLKERLLSCQQELDDLKER-YKELDDECETCAEYLQERDEQCARLKKEKLSL 882
+ K+ L Q +L+D KE+ +E+ D ++ E ++ L + L
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR----L 911
Query: 883 EQQVSNLKEQIRTQQPVERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKT 942
+ ++ L++ ++ Q ER D + + S D + K L +
Sbjct: 912 QDEIQRLRQALQASQ-AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
Query: 943 IEELRYKKQDLKNTV----TKMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKEL 998
+ L + + KNTV ++ + ++ + E +R +D + + L+++ K+L
Sbjct: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
Query: 999 ------DEECETCAEYLKQREEQCKRLKEAKIALEIVDK--LSNQKVALEKQIESLS 1047
E + + L Q E Q + L+E ++ E +K L + LE++++ LS
Sbjct: 1031 KTRLASSEGFQKPSASLSQLESQNQLLQE-RLQAEEREKTVLQSTNRKLERKVKELS 1086
Score = 50.8 bits (116), Expect = 3e-05
Identities = 151/843 (17%), Positives = 329/843 (39%), Gaps = 73/843 (8%)
Query: 223 LSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTSIKNHLELHEPNMTMDLD 282
L K+ + S+ ST K Q EL E+ + ++ + LE + + L+
Sbjct: 341 LEKMQPLVMVSSGST---KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLE 397
Query: 283 EKLGENNEFETKAVKVMSEIKRNLNSLSE-QLINNESKKSKDHIDRYKDSLLAVLDAEFG 341
EK E + + + E +++ L + + ++ + + ++ L L G
Sbjct: 398 EKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQG 457
Query: 342 TTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSELKSVNEKLASLNSQLIEK 401
E+L+ +++ ++ L+E+LE +V+ L EL ++ +L ++ +
Sbjct: 458 PEPAK--EVLLKDLLETREL-LEEVLEGKQRVEEQLRLRERELTALK---GALKEEVASR 511
Query: 402 ENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLKLSKLKIDIPRDLDQDLPA 461
+ +R Q +R E D + +L E K+S L + R+L++
Sbjct: 512 DQEVEHVRQQYQRDTEQLRRSMQDATQDH----AVLEAERQKMSALVRGLQRELEETSEE 567
Query: 462 HKKITILF-----DALITQYELSRTDYEIEKEKLRLETGTAKAVXXXXXXXXXXXXXXFD 516
+F D T+ EL + +EKE++ E G V
Sbjct: 568 TGHWQSMFQKNKEDLRATKQELLQL--RMEKEEMEEELGEKIEVLQRELEQARASAGDTR 625
Query: 517 TLEEAHNEVKSLHEELTKLYKSKVDENNANLNLIKILSEEIDALKIAIAKN---EEKMLS 573
+E E+ EEL +L + + A + + L +++ L++ + EE+ L
Sbjct: 626 QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQ 685
Query: 574 LSEKDNKLT---ELVSTINGLKEENNSL----KSLNDVITREKETQASELERSC----QV 622
L + +L E S + E ++ ++ + RE + + E R Q
Sbjct: 686 LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQ 745
Query: 623 IKQNGFELD-------KMKADILMXXXXXXXXXXXXXXXXDEAKSLLEQNLALKEQCEEK 675
+K+ +D +++ + +E SL AL+ + EE
Sbjct: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
Query: 676 TRDCSRLEINIKTHEKTAEI---QNRMIMRLQKQIQEDDKLFIEKETKLNELTNKY---- 728
R +RL +T + E Q ++ R + +++E +L +LN+ K
Sbjct: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDS 865
Query: 729 -EALKR------DY-DAAVKDLESSREAVNQLTTQKDLVEGRIAELESDIRTEQTATVXX 780
+AL++ DY + A +++ ++ ++ + G ++ L+ +I+ + A
Sbjct: 866 KQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQAS 925
Query: 781 XXXXXXXXXXXXXXXXXXXTFGDENRDLGENPKLD-DSPKRSISVISDSEVSQLKERLLS 839
E EN K D R + + + +VS+L+ L
Sbjct: 926 QAERDTARLDKELLAQRLQGLEQE----AENKKRSQDDRARQLKGLEE-KVSRLETELDE 980
Query: 840 CQQELDDLKERYKELDDECETC-AEYLQERDEQCARLKKEKLSLEQQVSNLKEQIRTQQP 898
+ ++ L +R D+ + E +QER + L+ +K+SLE+Q +LK ++ + +
Sbjct: 981 EKNTVELLTDRVNRGRDQVDQLRTELMQERSAR-QDLECDKISLERQNKDLKTRLASSEG 1039
Query: 899 VERQAKFADVAVNTDEDWANLHSVVVDRMSYDAEVEKNKRLMKTIEELRYKKQDLKNTVT 958
++ + A ++ ++ + + N++L + ++EL + +D + V
Sbjct: 1040 FQKPS--ASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVN 1097
Query: 959 KMQKAMEKYTKKDKEFEAKRKELEDCKAELEELKQRYKELDEECETCAEYLKQREEQCKR 1018
+ + K A ++++++ + E+E L K+ E E E +Q + + K
Sbjct: 1098 DQKDQLSLRVK------ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151
Query: 1019 LKE 1021
L++
Sbjct: 1152 LEK 1154
Score = 34.7 bits (76), Expect = 1.9
Identities = 58/280 (20%), Positives = 120/280 (42%), Gaps = 33/280 (11%)
Query: 826 SDSEVSQLKERLLSCQQELDDLKERYKELDDECETCAEYLQERDEQCARLKKEKLSLEQQ 885
S E L + + L++ + L E +T L+E +Q L++ K LE+Q
Sbjct: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ 843
Query: 886 -------VSNLKEQIR-----TQQPVER-QAKFADVAVNTDEDWANLHSVVVDRMSYDAE 932
V L +++ ++Q +++ QA+ D + A+ D + +E
Sbjct: 844 KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKD---WASE 900
Query: 933 VEKN----KRLMKTIEELRYKKQ--DLKNTVTKMQKAM--EKYTKKDKEFEAKRKELEDC 984
EK RL I+ LR Q + ++ K + ++ ++E E K++ +D
Sbjct: 901 AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR 960
Query: 985 KAELEELKQRYK----ELDEE---CETCAEYLKQREEQCKRLK-EAKIALEIVDKLSNQK 1036
+L+ L+++ ELDEE E + + + +Q +L+ E L K
Sbjct: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
Query: 1037 VALEKQIESLSNTPVSNSTMYVATGSAIVQNQQITDVMKE 1076
++LE+Q + L T +++S + +++ Q + +++E
Sbjct: 1021 ISLERQNKDL-KTRLASSEGFQKPSASLSQLESQNQLLQE 1059
Score = 34.3 bits (75), Expect = 2.5
Identities = 72/362 (19%), Positives = 147/362 (40%), Gaps = 33/362 (9%)
Query: 96 QNLILETQTRDLLMSQIKSLEMENLTKDKEIKNLTDSLKTKSKKINELQEENDTLSNLIM 155
QNL L+ +T L + + + E L + E QEEND I+
Sbjct: 682 QNLQLQ-KTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRIL 740
Query: 156 ---ENVTESDNL---NKEVDD-LKKNNECLTQKCIDLEKLVN---ESENKIGPKNICAQC 205
+ + E+ L + V+ L+ + L + LE+ +N E E + +
Sbjct: 741 GLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEA 800
Query: 206 KLKENLIQSLHIGYDNTLSKLNRSISDSNTSTRYNKICTLQSELDAGREDCKELCEDFTS 265
+L+E +G + LNR++ + + ++EL+ E + L
Sbjct: 801 RLEEAQRGLARLGQEQ--QTLNRALEEEGKQREVLR--RGKAELE---EQKRLLDRTVDR 853
Query: 266 IKNHLELHEPNMTMDLDEKLGENNEFETKAVKVMSEIKRNLNSLSEQLINNESKKSK--D 323
+ LE + L + + +++ KA + +++ +R + + S+ D
Sbjct: 854 LNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQD 913
Query: 324 HIDRYKDSLLAVLDAEFGTTSLDVFEILMDNIINKYQIDLDEILEKYTKVQGDLNECTSE 383
I R + +L A AE T LD E+L + L++ E + Q D +
Sbjct: 914 EIQRLRQALQAS-QAERDTARLDK-ELLAQRLQG-----LEQEAENKKRSQDDR---ARQ 963
Query: 384 LKSVNEKLASLNSQLIEKENACNILRIQKERIHEISSAVTIDIVKKENELKEILTKECLK 443
LK + EK++ L ++L E++N +L + R + + +++++ + +++ EC K
Sbjct: 964 LKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL---ECDK 1020
Query: 444 LS 445
+S
Sbjct: 1021 IS 1022
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.308 0.126 0.330
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 125,715,801
Number of Sequences: 224733
Number of extensions: 5068779
Number of successful extensions: 63453
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 2279
Number of HSP's that attempted gapping in prelim test: 31270
Number of HSP's gapped (non-prelim): 21475
length of query: 1109
length of database: 73,234,838
effective HSP length: 98
effective length of query: 1011
effective length of database: 51,211,004
effective search space: 51774325044
effective search space used: 51774325044
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.7 bits)
S2: 70 (32.3 bits)
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