Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000828-TA|BGIBMGA000828-PA|IPR008994|Nucleic
acid-binding, OB-fold, IPR001208|MCM, IPR008049|MCM protein 6
(799 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
D84557-1|BAA12699.1| 821|Homo sapiens HsMcm6 protein. 975 0.0
BC032374-1|AAH32374.1| 821|Homo sapiens minichromosome maintena... 975 0.0
AY220757-1|AAO26043.1| 821|Homo sapiens MCM6 minichromosome mai... 975 0.0
U46838-1|AAC50766.1| 821|Homo sapiens p105MCM protein. 954 0.0
AC011893-4|AAX88925.1| 785|Homo sapiens unknown protein. 947 0.0
X74794-1|CAA52801.1| 923|Homo sapiens P1 Cdc21 protein protein. 278 5e-74
BC031061-1|AAH31061.1| 863|Homo sapiens minichromosome maintena... 278 6e-74
AY588245-1|AAS83108.1| 863|Homo sapiens MCM4 minichromosome mai... 278 6e-74
D83986-1|BAA12176.1| 733|Homo sapiens huMCM5 protein. 277 1e-73
X74795-1|CAA52802.2| 734|Homo sapiens P1 Cdc46 protein. 275 3e-73
CR456517-1|CAG30403.1| 734|Homo sapiens MCM5 protein. 275 3e-73
BC000142-1|AAH00142.1| 734|Homo sapiens minichromosome maintena... 275 3e-73
AY212028-1|AAO21127.1| 734|Homo sapiens MCM5 minichromosome mai... 275 3e-73
BC003656-1|AAH03656.1| 734|Homo sapiens minichromosome maintena... 275 5e-73
AK223323-1|BAD97043.1| 734|Homo sapiens minichromosome maintena... 275 5e-73
Z82244-2|CAB05110.1| 733|Homo sapiens MCM5 minichromosome maint... 271 6e-72
D38073-1|BAA07267.1| 808|Homo sapiens hRlf beta subunit (p102 p... 271 6e-72
AB209612-1|BAD92849.1| 418|Homo sapiens minichromosome maintena... 270 1e-71
X62153-1|CAA44078.2| 808|Homo sapiens P1.h protein protein. 270 2e-71
BC003509-1|AAH03509.2| 808|Homo sapiens minichromosome maintena... 270 2e-71
BC001626-1|AAH01626.1| 808|Homo sapiens minichromosome maintena... 270 2e-71
AY621074-1|AAT27321.1| 808|Homo sapiens MCM3 minichromosome mai... 270 2e-71
AY032603-1|AAK56392.1| 676|Homo sapiens cervical cancer proto-o... 270 2e-71
AL034343-1|CAB75298.1| 808|Homo sapiens MCM3 minichromosome mai... 270 2e-71
AK222586-1|BAD96306.1| 808|Homo sapiens minichromosome maintena... 270 2e-71
U63630-1|AAC52018.1| 712|Homo sapiens MCM4 protein. 258 7e-68
X74796-1|CAA52803.1| 617|Homo sapiens p85Mcm protein protein. 252 5e-66
D55716-1|BAA09534.1| 719|Homo sapiens P1cdc47 protein. 252 5e-66
D28480-1|BAA05839.1| 543|Homo sapiens hMCM2 protein. 252 5e-66
BC013375-1|AAH13375.1| 719|Homo sapiens minichromosome maintena... 252 5e-66
D21063-1|BAA04642.1| 914|Homo sapiens KIAA0030 protein. 247 1e-64
BT009734-1|AAP88736.1| 895|Homo sapiens MCM2 minichromosome mai... 247 1e-64
BC030131-1|AAH30131.2| 808|Homo sapiens MCM2 protein protein. 247 1e-64
BC017490-1|AAH17490.2| 904|Homo sapiens minichromosome maintena... 247 1e-64
BC014272-1|AAH14272.2| 904|Homo sapiens minichromosome maintena... 247 1e-64
BC007938-1|AAH07938.2| 904|Homo sapiens minichromosome maintena... 247 1e-64
BC007670-1|AAH07670.2| 904|Homo sapiens minichromosome maintena... 247 1e-64
AY675259-1|AAT70723.1| 904|Homo sapiens MCM2 minichromosome mai... 247 1e-64
BC006165-1|AAH06165.3| 904|Homo sapiens minichromosome maintena... 246 3e-64
BC017258-1|AAH17258.2| 904|Homo sapiens minichromosome maintena... 244 1e-63
D83987-1|BAA12177.1| 895|Homo sapiens huMCM2 protein. 243 2e-63
X67334-1|CAA47749.1| 892|Homo sapiens polypeptide BM28 protein. 225 5e-58
BC101057-1|AAI01058.1| 840|Homo sapiens MCM8 protein protein. 225 5e-58
BC101056-1|AAI01057.1| 840|Homo sapiens minichromosome maintena... 225 5e-58
BC080656-1|AAH80656.1| 840|Homo sapiens minichromosome maintena... 225 5e-58
BC008830-1|AAH08830.2| 735|Homo sapiens MCM8 protein protein. 225 5e-58
AL035461-6|CAB55276.2| 840|Homo sapiens MCM8 minichromosome mai... 225 5e-58
AK027644-1|BAB55260.1| 603|Homo sapiens protein ( Homo sapiens ... 225 5e-58
AJ439063-1|CAD27750.1| 840|Homo sapiens minichromosome maintena... 225 5e-58
AY007130-1|AAG01994.1| 351|Homo sapiens protein ( Homo sapiens ... 223 3e-57
AY158211-1|AAO21222.1| 824|Homo sapiens MCM8 isoform protein. 209 3e-53
AL035461-7|CAI23480.1| 824|Homo sapiens MCM8 minichromosome mai... 209 3e-53
AK160378-1|BAD18721.1| 450|Homo sapiens FLJ00323 protein protein. 195 6e-49
BC101055-1|AAI01056.1| 880|Homo sapiens MCM8 protein protein. 190 2e-47
BC000300-1|AAH00300.2| 362|Homo sapiens MCM2 protein protein. 167 1e-40
BC101054-1|AAI01055.1| 793|Homo sapiens MCM8 protein protein. 156 3e-37
U67284-1|AAB48165.1| 181|Homo sapiens homolog of S. pombe mis5 ... 143 3e-33
AL132874-5|CAI42607.1| 451|Homo sapiens protein ( an). ).). 85 1e-15
BC031658-1|AAH31658.1| 391|Homo sapiens minichromosome maintena... 78 1e-13
AL132874-4|CAI42606.1| 156|Homo sapiens protein ( Human DNA seq... 78 1e-13
BC009398-1|AAH09398.1| 389|Homo sapiens MCM7 protein protein. 53 5e-06
AL034343-2|CAD92644.1| 328|Homo sapiens MCM3 minichromosome mai... 46 7e-04
U09584-1|AAA92281.1| 351|Homo sapiens PL6 protein protein. 33 3.0
CR457020-1|CAG33301.1| 351|Homo sapiens PL6 protein. 33 3.0
BC017367-1|AAH17367.1| 351|Homo sapiens transmembrane protein 1... 33 3.0
BC011948-1|AAH11948.1| 351|Homo sapiens transmembrane protein 1... 33 3.0
AC002481-1|AAB67308.1| 247|Homo sapiens PL6 protein, unknown fu... 33 3.0
CR457191-1|CAG33472.1| 303|Homo sapiens MRPL1 protein. 32 6.9
BC104483-1|AAI04484.1| 495|Homo sapiens SUV420H1 protein protein. 32 6.9
BC103498-1|AAI03499.1| 885|Homo sapiens suppressor of variegati... 32 6.9
BC099714-1|AAH99714.1| 885|Homo sapiens suppressor of variegati... 32 6.9
BC098121-1|AAH98121.1| 471|Homo sapiens SUV420H1 protein protein. 32 6.9
BC032595-1|AAH32595.1| 303|Homo sapiens mitochondrial ribosomal... 32 6.9
BC017765-1|AAH17765.1| 302|Homo sapiens Unknown (protein for IM... 32 6.9
BC015109-1|AAH15109.1| 303|Homo sapiens mitochondrial ribosomal... 32 6.9
BC014356-1|AAH14356.1| 303|Homo sapiens mitochondrial ribosomal... 32 6.9
BC012933-1|AAH12933.1| 414|Homo sapiens SUV420H1 protein protein. 32 6.9
AK000046-1|BAA90905.1| 414|Homo sapiens protein ( Homo sapiens ... 32 6.9
AC011999-1|AAY15028.1| 35|Homo sapiens unknown protein. 32 6.9
AB049474-1|BAB40180.1| 303|Homo sapiens mitochondrial ribosomal... 32 6.9
>D84557-1|BAA12699.1| 821|Homo sapiens HsMcm6 protein.
Length = 821
Score = 975 bits (2414), Expect = 0.0
Identities = 500/820 (60%), Positives = 616/820 (75%), Gaps = 49/820 (5%)
Query: 12 QVKDEVGIRCQKLFQDFLEEFKE-DNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLA 70
+V+DEV +CQKLF DFLEEF+ D EIKY + A+EL++PE +TL VSF D+E++NQ L+
Sbjct: 17 EVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLS 76
Query: 71 TTIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKI 130
TTI EE+YR+YP+L RA+ ++ E + KD YV+F D+PTRHK+RELT+++I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDF-----YVAFQDLPTRHKIRELTSSRI 131
Query: 131 GTLIRISGQIVRTHPVHPELVQGTF-----------------YTIPTICRNPVCANRRRF 173
G L RISGQ+VRTHPVHPELV GTF YT P ICRNPVCANRRRF
Sbjct: 132 GLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRF 191
Query: 174 MLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVV 233
+LD +KS FVDFQK+RIQETQAELPRG IPRSLEVILRAEAVES QAGD+ DFTGTLIVV
Sbjct: 192 LLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVV 251
Query: 234 PDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFG 293
PDV LS PG+RAE +R + + EGI+GL+ALGVR+L Y+ FLAC V + RFG
Sbjct: 252 PDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFG 311
Query: 294 TAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLM 353
EL + T E ++ QMT KEW+KV+EMS+D+NLY+NL TSLFP+IHGN+EVKRGVLLM
Sbjct: 312 GKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLM 371
Query: 354 LFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTA 413
LFGGV KTT EGT+LRGDINVCIVGDPSTAKSQ LK V E +PRAVYTSGKASSAAGLTA
Sbjct: 372 LFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTA 431
Query: 414 AVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRA 473
AVVRDEES +FVIEAGALMLADNGVCCIDEFDKMD DQVAIHEAMEQQTIS+ KAGV+A
Sbjct: 432 AVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKA 491
Query: 474 TLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARK 533
TLNARTSILAAANPI G YDR+KSL+QN+ LS PIMSRFDLFFIL+DE +E+ DYAIAR+
Sbjct: 492 TLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARR 551
Query: 534 IVDLHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYY-XXXXXXXXXXXX 592
IVDLH EES D VYS DD+ RY+ FAR FKP I++E+ +VE Y
Sbjct: 552 IVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTK 611
Query: 593 XXWRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEP 652
WRITVRQLESM+RL+E +A+MHC V P HV EA+RLLNKSIIRVE PD++LD++E
Sbjct: 612 SSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEE- 670
Query: 653 QCEPSMDVDQDEP--NGTAETPS------------NGDSAPKKKLALSFEEYKSLSNMLV 698
E M+VD+ NG A++P+ N +SAPK L L F EY +SN++V
Sbjct: 671 --EIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIV 728
Query: 699 VYMRKXXXXXXXXXXXSSGMHKSAVVSWYLEQLVAQGQIESEDELLERKTLVEKVIDRLM 758
+++RK S + +S +V+WYL+++ + +I+SE+EL+ +K ++EKVI RL
Sbjct: 729 LHLRK-----VEEEEDESALKRSELVNWYLKEI--ESEIDSEEELINKKRIIEKVIHRLT 781
Query: 759 YHDQVIIPLSTTGLRGTQKSSEQDIEDDPLLVVHPNYVVD 798
++D V+I L+ GL+G+ + SE E+DP LVV+PNY+++
Sbjct: 782 HYDHVLIELTQAGLKGSTEGSE-SYEEDPYLVVNPNYLLE 820
>BC032374-1|AAH32374.1| 821|Homo sapiens minichromosome maintenance
complex component 6 protein.
Length = 821
Score = 975 bits (2414), Expect = 0.0
Identities = 500/820 (60%), Positives = 616/820 (75%), Gaps = 49/820 (5%)
Query: 12 QVKDEVGIRCQKLFQDFLEEFKE-DNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLA 70
+V+DEV +CQKLF DFLEEF+ D EIKY + A+EL++PE +TL VSF D+E++NQ L+
Sbjct: 17 EVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLS 76
Query: 71 TTIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKI 130
TTI EE+YR+YP+L RA+ ++ E + KD YV+F D+PTRHK+RELT+++I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDF-----YVAFQDLPTRHKIRELTSSRI 131
Query: 131 GTLIRISGQIVRTHPVHPELVQGTF-----------------YTIPTICRNPVCANRRRF 173
G L RISGQ+VRTHPVHPELV GTF YT P ICRNPVCANRRRF
Sbjct: 132 GLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRF 191
Query: 174 MLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVV 233
+LD +KS FVDFQK+RIQETQAELPRG IPRSLEVILRAEAVES QAGD+ DFTGTLIVV
Sbjct: 192 LLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVV 251
Query: 234 PDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFG 293
PDV LS PG+RAE +R + + EGI+GL+ALGVR+L Y+ FLAC V + RFG
Sbjct: 252 PDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFG 311
Query: 294 TAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLM 353
EL + T E ++ QMT KEW+KV+EMS+D+NLY+NL TSLFP+IHGN+EVKRGVLLM
Sbjct: 312 GKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLM 371
Query: 354 LFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTA 413
LFGGV KTT EGT+LRGDINVCIVGDPSTAKSQ LK V E +PRAVYTSGKASSAAGLTA
Sbjct: 372 LFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTA 431
Query: 414 AVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRA 473
AVVRDEES +FVIEAGALMLADNGVCCIDEFDKMD DQVAIHEAMEQQTIS+ KAGV+A
Sbjct: 432 AVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKA 491
Query: 474 TLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARK 533
TLNARTSILAAANPI G YDR+KSL+QN+ LS PIMSRFDLFFIL+DE +E+ DYAIAR+
Sbjct: 492 TLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARR 551
Query: 534 IVDLHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYY-XXXXXXXXXXXX 592
IVDLH EES D VYS DD+ RY+ FAR FKP I++E+ +VE Y
Sbjct: 552 IVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTK 611
Query: 593 XXWRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEP 652
WRITVRQLESM+RL+E +A+MHC V P HV EA+RLLNKSIIRVE PD++LD++E
Sbjct: 612 SSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEE- 670
Query: 653 QCEPSMDVDQDEP--NGTAETPS------------NGDSAPKKKLALSFEEYKSLSNMLV 698
E M+VD+ NG A++P+ N +SAPK L L F EY +SN++V
Sbjct: 671 --EIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIV 728
Query: 699 VYMRKXXXXXXXXXXXSSGMHKSAVVSWYLEQLVAQGQIESEDELLERKTLVEKVIDRLM 758
+++RK S + +S +V+WYL+++ + +I+SE+EL+ +K ++EKVI RL
Sbjct: 729 LHLRK-----VEEEEDESALKRSELVNWYLKEI--ESEIDSEEELINKKRIIEKVIHRLT 781
Query: 759 YHDQVIIPLSTTGLRGTQKSSEQDIEDDPLLVVHPNYVVD 798
++D V+I L+ GL+G+ + SE E+DP LVV+PNY+++
Sbjct: 782 HYDHVLIELTQAGLKGSTEGSE-SYEEDPYLVVNPNYLLE 820
>AY220757-1|AAO26043.1| 821|Homo sapiens MCM6 minichromosome
maintenance deficient 6 (MIS5 homolog, S. pombe) (S.
cerevi protein.
Length = 821
Score = 975 bits (2414), Expect = 0.0
Identities = 500/820 (60%), Positives = 616/820 (75%), Gaps = 49/820 (5%)
Query: 12 QVKDEVGIRCQKLFQDFLEEFKE-DNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLA 70
+V+DEV +CQKLF DFLEEF+ D EIKY + A+EL++PE +TL VSF D+E++NQ L+
Sbjct: 17 EVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLS 76
Query: 71 TTIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKI 130
TTI EE+YR+YP+L RA+ ++ E + KD YV+F D+PTRHK+RELT+++I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDF-----YVAFQDLPTRHKIRELTSSRI 131
Query: 131 GTLIRISGQIVRTHPVHPELVQGTF-----------------YTIPTICRNPVCANRRRF 173
G L RISGQ+VRTHPVHPELV GTF YT P ICRNPVCANRRRF
Sbjct: 132 GLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRF 191
Query: 174 MLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVV 233
+LD +KS FVDFQK+RIQETQAELPRG IPRSLEVILRAEAVES QAGD+ DFTGTLIVV
Sbjct: 192 LLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVV 251
Query: 234 PDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFG 293
PDV LS PG+RAE +R + + EGI+GL+ALGVR+L Y+ FLAC V + RFG
Sbjct: 252 PDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFG 311
Query: 294 TAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLM 353
EL + T E ++ QMT KEW+KV+EMS+D+NLY+NL TSLFP+IHGN+EVKRGVLLM
Sbjct: 312 GKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLM 371
Query: 354 LFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTA 413
LFGGV KTT EGT+LRGDINVCIVGDPSTAKSQ LK V E +PRAVYTSGKASSAAGLTA
Sbjct: 372 LFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTA 431
Query: 414 AVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRA 473
AVVRDEES +FVIEAGALMLADNGVCCIDEFDKMD DQVAIHEAMEQQTIS+ KAGV+A
Sbjct: 432 AVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKA 491
Query: 474 TLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARK 533
TLNARTSILAAANPI G YDR+KSL+QN+ LS PIMSRFDLFFIL+DE +E+ DYAIAR+
Sbjct: 492 TLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARR 551
Query: 534 IVDLHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYY-XXXXXXXXXXXX 592
IVDLH EES D VYS DD+ RY+ FAR FKP I++E+ +VE Y
Sbjct: 552 IVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTK 611
Query: 593 XXWRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEP 652
WRITVRQLESM+RL+E +A+MHC V P HV EA+RLLNKSIIRVE PD++LD++E
Sbjct: 612 SSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEE- 670
Query: 653 QCEPSMDVDQDEP--NGTAETPS------------NGDSAPKKKLALSFEEYKSLSNMLV 698
E M+VD+ NG A++P+ N +SAPK L L F EY +SN++V
Sbjct: 671 --EIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIV 728
Query: 699 VYMRKXXXXXXXXXXXSSGMHKSAVVSWYLEQLVAQGQIESEDELLERKTLVEKVIDRLM 758
+++RK S + +S +V+WYL+++ + +I+SE+EL+ +K ++EKVI RL
Sbjct: 729 LHLRK-----VEEEEDESALKRSELVNWYLKEI--ESEIDSEEELINKKRIIEKVIHRLT 781
Query: 759 YHDQVIIPLSTTGLRGTQKSSEQDIEDDPLLVVHPNYVVD 798
++D V+I L+ GL+G+ + SE E+DP LVV+PNY+++
Sbjct: 782 HYDHVLIELTQAGLKGSTEGSE-SYEEDPYLVVNPNYLLE 820
>U46838-1|AAC50766.1| 821|Homo sapiens p105MCM protein.
Length = 821
Score = 954 bits (2362), Expect = 0.0
Identities = 491/820 (59%), Positives = 607/820 (74%), Gaps = 49/820 (5%)
Query: 12 QVKDEVGIRCQKLFQDFLEEFKE-DNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLA 70
+V+DEV +CQKLF DFLEEF+ D EIKY + A+EL++PE +TL VSF D+E++NQ L+
Sbjct: 17 EVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLS 76
Query: 71 TTIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKI 130
TTI EE+YR+YP+L RA+ ++ E + KD YV+F D+PTRHK+RELT+++I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDF-----YVAFQDLPTRHKIRELTSSRI 131
Query: 131 GTLIRISGQIVRTHPVHPELVQGTF-----------------YTIPTICRNPVCANRRRF 173
G L RISGQ+VRTHPVHPELV GTF YT P ICRNPVCANRRRF
Sbjct: 132 GLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRF 191
Query: 174 MLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVV 233
+LD +KS FVDFQK+RIQETQAELPRG IPRSLEVILRAEAVES QAGD+ DFTGTLIVV
Sbjct: 192 LLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVV 251
Query: 234 PDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFG 293
PDV LS PG+RAE +R + + EGI+GL+ALGVR+L Y+ FLAC V + RFG
Sbjct: 252 PDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFG 311
Query: 294 TAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLM 353
EL + T E ++ QMT KEW+KV+EMS+D+NLY+NL TSLFP+IHGN+EVKRGVLLM
Sbjct: 312 GKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLM 371
Query: 354 LFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTA 413
LFGGV+K GDINVCIVGDPSTAKSQ LK V E +PRAVYTSGKASSAAGLTA
Sbjct: 372 LFGGVSKDNRRRDLSSGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTA 431
Query: 414 AVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRA 473
AVVRDEES +FVIEAGALMLADNGVCCIDEFDKMD DQVAIHEAMEQQTIS+ KAGV+A
Sbjct: 432 AVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKA 491
Query: 474 TLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARK 533
TLN RTSILAAANPI G YDR+KSL+QN+ LS PIMSRFDLFFIL+DE +E+ DYAIAR+
Sbjct: 492 TLNTRTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARR 551
Query: 534 IVDLHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYY-XXXXXXXXXXXX 592
IVDLH EES D VYS DD+ RY+ FAR FKP I++E+ +VE Y
Sbjct: 552 IVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTK 611
Query: 593 XXWRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEP 652
WRITVRQLESM+RL+E +A+MHC V P HV EA+RLLNKSIIRVE PD++LD++E
Sbjct: 612 SSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEE- 670
Query: 653 QCEPSMDVDQDEP--NGTAETPS------------NGDSAPKKKLALSFEEYKSLSNMLV 698
E M+VD+ NG A++P+ N +SAPK L L F EY +SN++V
Sbjct: 671 --EIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIV 728
Query: 699 VYMRKXXXXXXXXXXXSSGMHKSAVVSWYLEQLVAQGQIESEDELLERKTLVEKVIDRLM 758
+++RK S + +S +V+WYL+++ + +I+SE+EL+ +K ++EKVI RL
Sbjct: 729 LHLRK-----VEEEEDESALKRSELVNWYLKEI--ESEIDSEEELINKKRIIEKVIHRLT 781
Query: 759 YHDQVIIPLSTTGLRGTQKSSEQDIEDDPLLVVHPNYVVD 798
++D V+I + GL+G+ + SE E+DP LVV+PNY+++
Sbjct: 782 HYDHVLIEPTQAGLKGSTEGSE-SYEEDPYLVVNPNYLLE 820
>AC011893-4|AAX88925.1| 785|Homo sapiens unknown protein.
Length = 785
Score = 947 bits (2343), Expect = 0.0
Identities = 485/796 (60%), Positives = 597/796 (75%), Gaps = 48/796 (6%)
Query: 35 DNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPFLNRAILNYILS 94
D EIKY + A+EL++PE +TL VSF D+E++NQ L+TTI EE+YR+YP+L RA+ ++
Sbjct: 5 DGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKD 64
Query: 95 LAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGT 154
E + KD YV+F D+PTRHK+RELT+++IG L RISGQ+VRTHPVHPELV GT
Sbjct: 65 RKEIPLAKDF-----YVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGT 119
Query: 155 F-----------------YTIPTICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAEL 197
F YT P ICRNPVCANRRRF+LD +KS FVDFQK+RIQETQAEL
Sbjct: 120 FLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAEL 179
Query: 198 PRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANE 257
PRG IPRSLEVILRAEAVES QAGD+ DFTGTLIVVPDV LS PG+RAE +R +
Sbjct: 180 PRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDG 239
Query: 258 GQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWD 317
+ EGI+GL+ALGVR+L Y+ FLAC V + RFG EL + T E ++ QMT KEW+
Sbjct: 240 YETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWE 299
Query: 318 KVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIV 377
KV+EMS+D+NLY+NL TSLFP+IHGN+EVKRGVLLMLFGGV KTT EGT+LRGDINVCIV
Sbjct: 300 KVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIV 359
Query: 378 GDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNG 437
GDPSTAKSQ LK V E +PRAVYTSGKASSAAGLTAAVVRDEES +FVIEAGALMLADNG
Sbjct: 360 GDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNG 419
Query: 438 VCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKS 497
VCCIDEFDKMD DQVAIHEAMEQQTIS+ KAGV+ATLNARTSILAAANPI G YDR+KS
Sbjct: 420 VCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKS 479
Query: 498 LQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLLRY 557
L+QN+ LS PIMSRFDLFFIL+DE +E+ DYAIAR+IVDLH EES D VYS DD+ RY
Sbjct: 480 LKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRY 539
Query: 558 IAFARSFKPVITEEAGKLLVEYY-XXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKMH 616
+ FAR FKP I++E+ +VE Y WRITVRQLESM+RL+E +A+MH
Sbjct: 540 LLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMH 599
Query: 617 CSGHVTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEP--NGTAETPS- 673
C V P HV EA+RLLNKSIIRVE PD++LD++E E M+VD+ NG A++P+
Sbjct: 600 CCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEE---EIQMEVDEGAGGINGHADSPAP 656
Query: 674 -----------NGDSAPKKKLALSFEEYKSLSNMLVVYMRKXXXXXXXXXXXSSGMHKSA 722
N +SAPK L L F EY +SN++V+++RK S + +S
Sbjct: 657 VNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRK-----VEEEEDESALKRSE 711
Query: 723 VVSWYLEQLVAQGQIESEDELLERKTLVEKVIDRLMYHDQVIIPLSTTGLRGTQKSSEQD 782
+V+WYL+++ + +I+SE+EL+ +K ++EKVI RL ++D V+I L+ GL+G+ + SE
Sbjct: 712 LVNWYLKEI--ESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSE-S 768
Query: 783 IEDDPLLVVHPNYVVD 798
E+DP LVV+PNY+++
Sbjct: 769 YEEDPYLVVNPNYLLE 784
>X74794-1|CAA52801.1| 923|Homo sapiens P1 Cdc21 protein protein.
Length = 923
Score = 278 bits (682), Expect = 5e-74
Identities = 204/636 (32%), Positives = 324/636 (50%), Gaps = 47/636 (7%)
Query: 21 CQKLFQDFLEEF------KEDN------EIKYEKHAKELLKPELSTLEVSFDDVEKYNQN 68
C++ FQ FL+ F +E+N E Y + E+ L V+ + ++ +++N
Sbjct: 222 CKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEQFLNVNCEHIKSFDKN 281
Query: 69 LATTIIEEYYRIYPFLNRAILNYILS-LAETGMKKDLQDKECYVSFVDVPTRHKVRELTT 127
L +I + P + A+ ++ ++ +Q + F + T++ +R L
Sbjct: 282 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRP----FNALKTKN-MRNLNP 336
Query: 128 AKIGTLIRISGQIVRTHPVHPELVQGTFYTIPTICRNPVCANRRRFMLDADKSVFVDF-Q 186
I LI ISG ++RT + PE+ + F C+ VCA+ R +D +
Sbjct: 337 EDIDQLITISGMVIRTSQLIPEMQEAFFQ-----CQ--VCAHTTRVEMDRGRIAEPSVCG 389
Query: 187 KIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRA 246
+ + A + + ++I E+ E + AG T L D+ PG R
Sbjct: 390 RCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQT-PHTVILFAHNDLVDKVQPGDRV 448
Query: 247 EITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTED 306
+T + + +K++ YKT + + R A+ H L E
Sbjct: 449 NVTGIYRAVPIRVNPRVSNVKSV------YKT-----HIDVIHYRKTDAKR-LHGLDEEA 496
Query: 307 MRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKT---TI 363
+K ++K + + E+SR ++Y L ++L PSI+ + ++K+G+LL LFGG K T
Sbjct: 497 EQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTG 556
Query: 364 EGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFD 423
G R +IN+ + GDP T+KSQLL+ V + PR YTSGK SSA GLTA V++D E+
Sbjct: 557 RGK-FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQ 615
Query: 424 FVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILA 483
V++ GAL+L+DNG+CCIDEFDKM+ + +HE MEQQT+S+AKAG+ LNARTS+LA
Sbjct: 616 LVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLA 675
Query: 484 AANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEE 543
AANPI +++ K+ +N+ L ++SRFDL F+++D E D +A +V L+ EE
Sbjct: 676 AANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEE 735
Query: 544 -SYDCVYSRDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQ 601
+ + + L YIA+A S P ++EEA + L+E Y RQ
Sbjct: 736 QAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVS--AYPRQ 793
Query: 602 LESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSI 637
LES++RLAE AK+ S V V EA RL +++
Sbjct: 794 LESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREAL 829
>BC031061-1|AAH31061.1| 863|Homo sapiens minichromosome maintenance
complex component 4 protein.
Length = 863
Score = 278 bits (681), Expect = 6e-74
Identities = 202/636 (31%), Positives = 325/636 (51%), Gaps = 47/636 (7%)
Query: 21 CQKLFQDFLEEFKEDNEIKYEKHAKELLKP-------ELST-----LEVSFDDVEKYNQN 68
C++ FQ FL+ F + + E ++ +P E++ L V+ + ++ +++N
Sbjct: 162 CKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKN 221
Query: 69 LATTIIEEYYRIYPFLNRAILNYILS-LAETGMKKDLQDKECYVSFVDVPTRHKVRELTT 127
L +I + P + A+ ++ ++ +Q + F + T++ +R L
Sbjct: 222 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRP----FNALKTKN-MRNLNP 276
Query: 128 AKIGTLIRISGQIVRTHPVHPELVQGTFYTIPTICRNPVCANRRRFMLDADKSVFVDF-Q 186
I LI ISG ++RT + PE+ + F C+ VCA+ R +D +
Sbjct: 277 EDIDQLITISGMVIRTSQLIPEMQEAFFQ-----CQ--VCAHTTRVEMDRGRIAEPSVCG 329
Query: 187 KIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRA 246
+ + A + + ++I E+ E + AG T L D+ PG R
Sbjct: 330 RCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQT-PHTVILFAHNDLVDKVQPGDRV 388
Query: 247 EITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTED 306
+T + + +K++ YKT + + R A+ H L E
Sbjct: 389 NVTGIYRAVPIRVNPRVSNVKSV------YKT-----HIDVIHYRKTDAKR-LHGLDEEA 436
Query: 307 MRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKT---TI 363
+K ++K + + E+SR ++Y L ++L PSI+ + ++K+G+LL LFGG K T
Sbjct: 437 EQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTG 496
Query: 364 EGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFD 423
G R +IN+ + GDP T+KSQLL+ V + PR YTSGK SSA GLTA V++D E+
Sbjct: 497 RGK-FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQ 555
Query: 424 FVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILA 483
V++ GAL+L+DNG+CCIDEFDKM+ + +HE MEQQT+S+AKAG+ LNARTS+LA
Sbjct: 556 LVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLA 615
Query: 484 AANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEE 543
AANPI +++ K+ +N+ L ++SRFDL F+++D E D +A +V L+ EE
Sbjct: 616 AANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEE 675
Query: 544 -SYDCVYSRDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQ 601
+ + + L YIA+A S P ++EEA + L+E Y RQ
Sbjct: 676 QAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVS--AYPRQ 733
Query: 602 LESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSI 637
LES++RLAE AK+ S V V EA RL +++
Sbjct: 734 LESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREAL 769
>AY588245-1|AAS83108.1| 863|Homo sapiens MCM4 minichromosome
maintenance deficient 4 (S. cerevisiae) protein.
Length = 863
Score = 278 bits (681), Expect = 6e-74
Identities = 202/636 (31%), Positives = 325/636 (51%), Gaps = 47/636 (7%)
Query: 21 CQKLFQDFLEEFKEDNEIKYEKHAKELLKP-------ELST-----LEVSFDDVEKYNQN 68
C++ FQ FL+ F + + E ++ +P E++ L V+ + ++ +++N
Sbjct: 162 CKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKN 221
Query: 69 LATTIIEEYYRIYPFLNRAILNYILS-LAETGMKKDLQDKECYVSFVDVPTRHKVRELTT 127
L +I + P + A+ ++ ++ +Q + F + T++ +R L
Sbjct: 222 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRP----FNALKTKN-MRNLNP 276
Query: 128 AKIGTLIRISGQIVRTHPVHPELVQGTFYTIPTICRNPVCANRRRFMLDADKSVFVDF-Q 186
I LI ISG ++RT + PE+ + F C+ VCA+ R +D +
Sbjct: 277 EDIDQLITISGMVIRTSQLIPEMQEAFFQ-----CQ--VCAHTTRVEMDRGRIAEPSVCG 329
Query: 187 KIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRA 246
+ + A + + ++I E+ E + AG T L D+ PG R
Sbjct: 330 RCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQT-PHTVILFAHNDLVDKVQPGDRV 388
Query: 247 EITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTED 306
+T + + +K++ YKT + + R A+ H L E
Sbjct: 389 NVTGIYRAVPIRVNPRVSNVKSV------YKT-----HIDVIHYRKTDAKR-LHGLDEEA 436
Query: 307 MRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKT---TI 363
+K ++K + + E+SR ++Y L ++L PSI+ + ++K+G+LL LFGG K T
Sbjct: 437 EQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTG 496
Query: 364 EGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFD 423
G R +IN+ + GDP T+KSQLL+ V + PR YTSGK SSA GLTA V++D E+
Sbjct: 497 RGK-FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQ 555
Query: 424 FVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILA 483
V++ GAL+L+DNG+CCIDEFDKM+ + +HE MEQQT+S+AKAG+ LNARTS+LA
Sbjct: 556 LVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLA 615
Query: 484 AANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEE 543
AANPI +++ K+ +N+ L ++SRFDL F+++D E D +A +V L+ EE
Sbjct: 616 AANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEE 675
Query: 544 -SYDCVYSRDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQ 601
+ + + L YIA+A S P ++EEA + L+E Y RQ
Sbjct: 676 QAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVS--AYPRQ 733
Query: 602 LESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSI 637
LES++RLAE AK+ S V V EA RL +++
Sbjct: 734 LESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREAL 769
>D83986-1|BAA12176.1| 733|Homo sapiens huMCM5 protein.
Length = 733
Score = 277 bits (678), Expect = 1e-73
Identities = 211/675 (31%), Positives = 333/675 (49%), Gaps = 85/675 (12%)
Query: 5 DTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNE-----IKYEKHAKELLKPELSTLEVSF 59
D A + Q + + Q+ F++FL +++ + KY K +EV
Sbjct: 18 DAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEM 74
Query: 60 DDVEKYNQNLATTIIE---EYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDV 116
+D+ ++++LA + + E+ ++ + + + + +G ++ LQD + +
Sbjct: 75 EDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSG-EEVLQDIQVMLKSDAS 133
Query: 117 PTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF--------------------Y 156
P+ +R L + + L++I G I+ V + + + Y
Sbjct: 134 PS--SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGY 191
Query: 157 TIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVILR 211
+P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 192 ALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCD 250
Query: 212 AEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGV 271
+ V G+R T++ + + + SR R ++ +G+
Sbjct: 251 RYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VGI 289
Query: 272 RELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 290 RSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYEV 334
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQV 391
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK V
Sbjct: 335 ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFV 394
Query: 392 SEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGD 451
+ +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM D
Sbjct: 395 EKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
Query: 452 QVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSR 511
+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+SR
Sbjct: 455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSR 513
Query: 512 FDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKPV 567
FD+ FI+ DE +E+ D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 514 FDMIFIVKDEHNEVRDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPR 573
Query: 568 ITEEAGKLLVEYY----XXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKMHCSGHVTP 623
++ EA + L Y ITVRQLE++VR+AE ++KM T
Sbjct: 574 LSAEAAEKLKNRYIIMRTGPVSTRGTVTASSIPITVRQLEAIVRIAEALSKMKLQPFATE 633
Query: 624 AHVHEAYRLLNKSII 638
A V EA RL S +
Sbjct: 634 ADVEEALRLFQVSTL 648
>X74795-1|CAA52802.2| 734|Homo sapiens P1 Cdc46 protein.
Length = 734
Score = 275 bits (675), Expect = 3e-73
Identities = 212/676 (31%), Positives = 333/676 (49%), Gaps = 86/676 (12%)
Query: 5 DTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNE-----IKYEKHAKELLKPELSTLEVSF 59
D A + Q + + Q+ F++FL +++ + KY K +EV
Sbjct: 18 DAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEM 74
Query: 60 DDVEKYNQNLATTIIE---EYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDV 116
+D+ ++++LA + + E+ ++ + + + + +G ++ LQD + +
Sbjct: 75 EDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSG-EEVLQDIQVMLKSDAS 133
Query: 117 PTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF--------------------Y 156
P+ +R L + + L++I G I+ V + + + Y
Sbjct: 134 PS--SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGY 191
Query: 157 TIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVILR 211
+P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 192 ALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCD 250
Query: 212 AEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGV 271
+ V G+R T++ + + + SR R ++ +G+
Sbjct: 251 RYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VGI 289
Query: 272 RELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 290 RSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYEV 334
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQV 391
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK V
Sbjct: 335 ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFV 394
Query: 392 SEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGD 451
+ +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM D
Sbjct: 395 EKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
Query: 452 QVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSR 511
+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+SR
Sbjct: 455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSR 513
Query: 512 FDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKPV 567
FD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 514 FDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPR 573
Query: 568 ITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHVT 622
++ EA + L Y R ITVRQLE++VR+AE ++KM T
Sbjct: 574 LSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFAT 633
Query: 623 PAHVHEAYRLLNKSII 638
A V EA RL S +
Sbjct: 634 EADVEEALRLFQVSTL 649
>CR456517-1|CAG30403.1| 734|Homo sapiens MCM5 protein.
Length = 734
Score = 275 bits (675), Expect = 3e-73
Identities = 212/676 (31%), Positives = 333/676 (49%), Gaps = 86/676 (12%)
Query: 5 DTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNE-----IKYEKHAKELLKPELSTLEVSF 59
D A + Q + + Q+ F++FL +++ + KY K +EV
Sbjct: 18 DAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEM 74
Query: 60 DDVEKYNQNLATTIIE---EYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDV 116
+D+ ++++LA + + E+ ++ + + + + +G ++ LQD + +
Sbjct: 75 EDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSG-EEVLQDIQVMLKSDAS 133
Query: 117 PTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF--------------------Y 156
P+ +R L + + L++I G I+ V + + + Y
Sbjct: 134 PS--SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGY 191
Query: 157 TIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVILR 211
+P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 192 ALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCD 250
Query: 212 AEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGV 271
+ V G+R T++ + + + SR R ++ +G+
Sbjct: 251 RYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VGI 289
Query: 272 RELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 290 RSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYEV 334
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQV 391
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK V
Sbjct: 335 ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFV 394
Query: 392 SEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGD 451
+ +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM D
Sbjct: 395 EKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
Query: 452 QVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSR 511
+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+SR
Sbjct: 455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSR 513
Query: 512 FDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKPV 567
FD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 514 FDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPR 573
Query: 568 ITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHVT 622
++ EA + L Y R ITVRQLE++VR+AE ++KM T
Sbjct: 574 LSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFAT 633
Query: 623 PAHVHEAYRLLNKSII 638
A V EA RL S +
Sbjct: 634 EADVEEALRLFQVSTL 649
>BC000142-1|AAH00142.1| 734|Homo sapiens minichromosome maintenance
complex component 5 protein.
Length = 734
Score = 275 bits (675), Expect = 3e-73
Identities = 212/676 (31%), Positives = 333/676 (49%), Gaps = 86/676 (12%)
Query: 5 DTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNE-----IKYEKHAKELLKPELSTLEVSF 59
D A + Q + + Q+ F++FL +++ + KY K +EV
Sbjct: 18 DAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEM 74
Query: 60 DDVEKYNQNLATTIIE---EYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDV 116
+D+ ++++LA + + E+ ++ + + + + +G ++ LQD + +
Sbjct: 75 EDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSG-EEVLQDIQVMLKSDAS 133
Query: 117 PTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF--------------------Y 156
P+ +R L + + L++I G I+ V + + + Y
Sbjct: 134 PS--SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGY 191
Query: 157 TIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVILR 211
+P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 192 ALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCD 250
Query: 212 AEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGV 271
+ V G+R T++ + + + SR R ++ +G+
Sbjct: 251 RYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VGI 289
Query: 272 RELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 290 RSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYEV 334
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQV 391
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK V
Sbjct: 335 ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFV 394
Query: 392 SEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGD 451
+ +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM D
Sbjct: 395 EKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
Query: 452 QVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSR 511
+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+SR
Sbjct: 455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSR 513
Query: 512 FDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKPV 567
FD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 514 FDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPR 573
Query: 568 ITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHVT 622
++ EA + L Y R ITVRQLE++VR+AE ++KM T
Sbjct: 574 LSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFAT 633
Query: 623 PAHVHEAYRLLNKSII 638
A V EA RL S +
Sbjct: 634 EADVEEALRLFQVSTL 649
>AY212028-1|AAO21127.1| 734|Homo sapiens MCM5 minichromosome
maintenance deficient 5, cell division cycle 46 (S.
cerevis protein.
Length = 734
Score = 275 bits (675), Expect = 3e-73
Identities = 212/676 (31%), Positives = 333/676 (49%), Gaps = 86/676 (12%)
Query: 5 DTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNE-----IKYEKHAKELLKPELSTLEVSF 59
D A + Q + + Q+ F++FL +++ + KY K +EV
Sbjct: 18 DAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEM 74
Query: 60 DDVEKYNQNLATTIIE---EYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDV 116
+D+ ++++LA + + E+ ++ + + + + +G ++ LQD + +
Sbjct: 75 EDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSG-EEVLQDIQVMLKSDAS 133
Query: 117 PTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF--------------------Y 156
P+ +R L + + L++I G I+ V + + + Y
Sbjct: 134 PS--SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGY 191
Query: 157 TIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVILR 211
+P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 192 ALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCD 250
Query: 212 AEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGV 271
+ V G+R T++ + + + SR R ++ +G+
Sbjct: 251 RYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VGI 289
Query: 272 RELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 290 RSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYEV 334
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQV 391
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK V
Sbjct: 335 ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFV 394
Query: 392 SEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGD 451
+ +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM D
Sbjct: 395 EKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
Query: 452 QVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSR 511
+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+SR
Sbjct: 455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSR 513
Query: 512 FDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKPV 567
FD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 514 FDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPR 573
Query: 568 ITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHVT 622
++ EA + L Y R ITVRQLE++VR+AE ++KM T
Sbjct: 574 LSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFAT 633
Query: 623 PAHVHEAYRLLNKSII 638
A V EA RL S +
Sbjct: 634 EADVEEALRLFQVSTL 649
>BC003656-1|AAH03656.1| 734|Homo sapiens minichromosome maintenance
complex component 5 protein.
Length = 734
Score = 275 bits (674), Expect = 5e-73
Identities = 184/497 (37%), Positives = 264/497 (53%), Gaps = 52/497 (10%)
Query: 156 YTIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVIL 210
Y +P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 191 YALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYC 249
Query: 211 RAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALG 270
+ V G+R T++ + + + SR R ++ +G
Sbjct: 250 DRYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VG 288
Query: 271 VRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYN 330
+R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 289 IRSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYE 333
Query: 331 NLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQ 390
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK
Sbjct: 334 VISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKF 393
Query: 391 VSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPG 450
V + +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM
Sbjct: 394 VEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMRED 453
Query: 451 DQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMS 510
D+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+S
Sbjct: 454 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILS 512
Query: 511 RFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKP 566
RFD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 513 RFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGP 572
Query: 567 VITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHV 621
++ EA + L Y R ITVRQLE++VR+AE ++KM
Sbjct: 573 RLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFA 632
Query: 622 TPAHVHEAYRLLNKSII 638
T A V EA RL S +
Sbjct: 633 TEADVEEALRLFQVSTL 649
>AK223323-1|BAD97043.1| 734|Homo sapiens minichromosome maintenance
deficient protein 5 variant protein.
Length = 734
Score = 275 bits (674), Expect = 5e-73
Identities = 184/497 (37%), Positives = 264/497 (53%), Gaps = 52/497 (10%)
Query: 156 YTIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVIL 210
Y +P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 191 YALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYC 249
Query: 211 RAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALG 270
+ V G+R T++ + + + SR R ++ +G
Sbjct: 250 DRYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VG 288
Query: 271 VRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYN 330
+R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 289 IRSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYE 333
Query: 331 NLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQ 390
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK
Sbjct: 334 VISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKF 393
Query: 391 VSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPG 450
V + +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM
Sbjct: 394 VEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMRED 453
Query: 451 DQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMS 510
D+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+S
Sbjct: 454 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILS 512
Query: 511 RFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKP 566
RFD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 513 RFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGP 572
Query: 567 VITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHV 621
++ EA + L Y R ITVRQLE++VR+AE ++KM
Sbjct: 573 RLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFA 632
Query: 622 TPAHVHEAYRLLNKSII 638
T A V EA RL S +
Sbjct: 633 TEADVEEALRLFQVSTL 649
>Z82244-2|CAB05110.1| 733|Homo sapiens MCM5 minichromosome
maintenance deficient 5, cellr) protein.
Length = 733
Score = 271 bits (665), Expect = 6e-72
Identities = 212/676 (31%), Positives = 333/676 (49%), Gaps = 87/676 (12%)
Query: 5 DTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNE-----IKYEKHAKELLKPELSTLEVSF 59
D A + Q + + Q+ F++FL +++ + KY K +EV
Sbjct: 18 DAQADEGQARKS---QLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEM 74
Query: 60 DDVEKYNQNLATTIIE---EYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDV 116
+D+ ++++LA + + E+ ++ + + + + +G ++ LQD + +
Sbjct: 75 EDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSG-EEVLQDIQVMLKSDAS 133
Query: 117 PTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF--------------------Y 156
P+ +R L + + L++I G I+ V + + + Y
Sbjct: 134 PS--SIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGY 191
Query: 157 TIPTICRNPVCANRRRFMLDA-----DKSVFVDFQKIRIQETQAELPRGCIPRSLEVILR 211
+P C N A R + LD DK VDFQ +++QE +P G +PR +++
Sbjct: 192 ALPRKC-NTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCD 250
Query: 212 AEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGV 271
+ V G+R T++ + + + SR R ++ +G+
Sbjct: 251 RYLCDKVVPGNRV----TIMGIYSIKKFGLTTSRG----RDRVG-------------VGI 289
Query: 272 RELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
R + + + R F A P + E+ R+ ++ N+Y
Sbjct: 290 RSSYIRVLGIQVDTDGSGRSFAGAVSPQEE---EEFRR------------LAALPNVYEV 334
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQV 391
+ S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQLLK V
Sbjct: 335 ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFV 394
Query: 392 SEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGD 451
+ +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDKM D
Sbjct: 395 EKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
Query: 452 QVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSR 511
+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P I+SR
Sbjct: 455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSR 513
Query: 512 FDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR-SFKPV 567
FD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R P
Sbjct: 514 FDMIFIVKDEHNEERD-MLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPR 572
Query: 568 ITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHCSGHVT 622
++ EA + L Y R ITVRQLE++VR+AE ++KM T
Sbjct: 573 LSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFAT 632
Query: 623 PAHVHEAYRLLNKSII 638
A V EA RL S +
Sbjct: 633 EADVEEALRLFQVSTL 648
>D38073-1|BAA07267.1| 808|Homo sapiens hRlf beta subunit (p102
protein) protein.
Length = 808
Score = 271 bits (665), Expect = 6e-72
Identities = 185/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ AGDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKANAGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>AB209612-1|BAD92849.1| 418|Homo sapiens minichromosome maintenance
deficient protein 5 variant protein.
Length = 418
Score = 270 bits (662), Expect = 1e-71
Identities = 149/321 (46%), Positives = 200/321 (62%), Gaps = 10/321 (3%)
Query: 327 NLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQ 386
N+Y + S+ PSI G ++K+ + +LFGG K +G T RGDIN+ ++GDP TAKSQ
Sbjct: 47 NVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQ 106
Query: 387 LLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDK 446
LLK V + +P VYTSGK SSAAGLTA+V+RD S +F++E GA++LAD GV CIDEFDK
Sbjct: 107 LLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDK 166
Query: 447 MDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSP 506
M D+VAIHEAMEQQTIS+AKAG+ TLN+R S+LAAAN + GR+D K + N+ P
Sbjct: 167 MREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMP 225
Query: 507 PIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL---RYIAFAR- 562
I+SRFD+ FI+ DE +E D +A+ ++ LH + V DL ++IA+ R
Sbjct: 226 TILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRV 285
Query: 563 SFKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWR-----ITVRQLESMVRLAEGVAKMHC 617
P ++ EA + L Y R ITVRQLE++VR+AE ++KM
Sbjct: 286 KCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKL 345
Query: 618 SGHVTPAHVHEAYRLLNKSII 638
T A V EA RL S +
Sbjct: 346 QPFATEADVEEALRLFQVSTL 366
>X62153-1|CAA44078.2| 808|Homo sapiens P1.h protein protein.
Length = 808
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>BC003509-1|AAH03509.2| 808|Homo sapiens minichromosome maintenance
complex component 3 protein.
Length = 808
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>BC001626-1|AAH01626.1| 808|Homo sapiens minichromosome maintenance
complex component 3 protein.
Length = 808
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>AY621074-1|AAT27321.1| 808|Homo sapiens MCM3 minichromosome
maintenance deficient 3 (S. cerevisiae) protein.
Length = 808
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>AY032603-1|AAK56392.1| 676|Homo sapiens cervical cancer
proto-oncogene 5 protein.
Length = 676
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 43.2 bits (97), Expect = 0.004
Identities = 35/125 (28%), Positives = 53/125 (42%), Gaps = 7/125 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCE 655
E + E
Sbjct: 671 ESETE 675
>AL034343-1|CAB75298.1| 808|Homo sapiens MCM3 minichromosome
maintenance deficient 3 (S. cerevisiae) protein.
Length = 808
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>AK222586-1|BAD96306.1| 808|Homo sapiens minichromosome maintenance
protein 3 variant protein.
Length = 808
Score = 270 bits (661), Expect = 2e-71
Identities = 184/549 (33%), Positives = 296/549 (53%), Gaps = 72/549 (13%)
Query: 13 VKDEVGIR-CQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLAT 71
V D+V +R Q+ + DFL++ +ED I Y+ +EL+ L V+ +D+ + N+ A
Sbjct: 6 VLDDVELREAQRDYLDFLDD-EEDQGI-YQSKVRELISDNQYRLIVNVNDLRRKNEKRAN 63
Query: 72 TIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFV-DVPTRH-KVRELTTAK 129
++ + RA+ +++ S+ T K Q +E YV ++H R LT+
Sbjct: 64 RLLNNAFEELVAFQRALKDFVASIDATYAK---QYEEFYVGLEGSFGSKHVSPRTLTSCF 120
Query: 130 IGTLIRISGQIVRTHPVHPELVQGTFYT-------------IPTICRNPVCA-----NRR 171
+ ++ + G + + V P++V+ Y + T+ P + +
Sbjct: 121 LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE 180
Query: 172 RFMLDADK--SVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGT 229
L+ + SV+ D Q I IQE + P G +PRS++VIL + V+ + GDR GT
Sbjct: 181 NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT 240
Query: 230 LIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVS 289
+PG + T+ T ++T +AC+V+ +S
Sbjct: 241 Y--------RCLPGKKGGYTSGT-----------------------FRTVLIACNVKQMS 269
Query: 290 RRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRG 349
+ A+ P+ + ED+ K K + +R +++++ L SL PSIHG++ VK+
Sbjct: 270 K---DAQ-PS--FSAEDIAKI-------KKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKA 316
Query: 350 VLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAA 409
+L +L GGV + G+ +RGDIN+ ++GDPS AKSQLL+ V PRA+ T+G+ SS
Sbjct: 317 ILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGV 376
Query: 410 GLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKA 469
GLTAAV D+E+ + +EAGA++LAD GV CIDEFDKM D+ AIHE MEQ +++AKA
Sbjct: 377 GLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKA 436
Query: 470 GVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYA 529
G+ A LNAR S+LAAANP+ GRYD+ K+ +N+ L ++SRFDL FI++D+ D
Sbjct: 437 GIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE 496
Query: 530 IARKIVDLH 538
I+ ++ +H
Sbjct: 497 ISDHVLRMH 505
Score = 46.8 bits (106), Expect = 3e-04
Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ + V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 552 LHGTKKKKEEMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 610
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 611 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 670
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 671 ESETEDEEEKSQED 684
>U63630-1|AAC52018.1| 712|Homo sapiens MCM4 protein.
Length = 712
Score = 258 bits (631), Expect = 7e-68
Identities = 184/577 (31%), Positives = 300/577 (51%), Gaps = 45/577 (7%)
Query: 21 CQKLFQDFLEEFKEDNEIKYEKHAKELLKP-------ELST-----LEVSFDDVEKYNQN 68
C++ FQ FL+ F + + E ++ +P E++ L V+ + ++ +++N
Sbjct: 162 CKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKN 221
Query: 69 LATTIIEEYYRIYPFLNRAILNYILS-LAETGMKKDLQDKECYVSFVDVPTRHKVRELTT 127
L +I + P + A+ ++ ++ +Q + F + T++ +R L
Sbjct: 222 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRP----FNALKTKN-MRNLNP 276
Query: 128 AKIGTLIRISGQIVRTHPVHPELVQGTFYTIPTICRNPVCANRRRFMLDADKSVFVDF-Q 186
I LI ISG ++RT + PE+ + F C+ VCA+ R +D +
Sbjct: 277 EDIDQLITISGMVIRTSQLIPEMQEAFFQ-----CQ--VCAHTTRVEMDRGRIAEPSVCG 329
Query: 187 KIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRA 246
+ + A + + ++I E+ E + AG T L D+ PG R
Sbjct: 330 RCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQT-PHTVILFAHNDLVDKVQPGDRV 388
Query: 247 EITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTED 306
+T + + +K++ YKT + + R A+ H L E
Sbjct: 389 NVTGIYRAVPIRVNPRVSNVKSV------YKT-----HIDVIHYRKTDAKR-LHGLDEEA 436
Query: 307 MRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKT---TI 363
+K ++K + + E+SR ++Y L ++L PSI+ + ++K+G+LL LFGG K T
Sbjct: 437 EQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTG 496
Query: 364 EGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFD 423
G R +IN+ + GDP T+KSQLL+ V + PR YTSGK SSA GLTA V++D E+
Sbjct: 497 RGK-FRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQ 555
Query: 424 FVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILA 483
V++ GAL+L+DNG+CCIDEFDKM+ + +HE MEQQT+S+AKAG+ LNARTS+LA
Sbjct: 556 LVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLA 615
Query: 484 AANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEE 543
AANPI +++ K+ +N+ L ++SRFDL F+L+D E D +A +V L+ EE
Sbjct: 616 AANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEE 675
Query: 544 -SYDCVYSRDDLLRYIAFARS-FKPVITEEAGKLLVE 578
+ + + L YIA+A S P ++EEA + L+E
Sbjct: 676 QAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIE 712
>X74796-1|CAA52803.1| 617|Homo sapiens p85Mcm protein protein.
Length = 617
Score = 252 bits (616), Expect = 5e-66
Identities = 132/314 (42%), Positives = 189/314 (60%), Gaps = 4/314 (1%)
Query: 325 DRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAK 384
+ + Y L S+ P I+G+ +VK+ +LL+L GGV ++ G +RG+IN+C++GDP AK
Sbjct: 227 EEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSP-RGMKIRGNINICLMGDPGVAK 285
Query: 385 SQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEF 444
SQLL + + PR+ YT+G+ SS GLTAAV+RD S + +E GAL+LAD GVCCIDEF
Sbjct: 286 SQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEF 345
Query: 445 DKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVAL 504
DKM D+ AIHE MEQQTIS+AKAG+ TLNAR SILAAANP GRY+ +SL+QN+ L
Sbjct: 346 DKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQL 405
Query: 505 SPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL--RYIAFAR 562
++SRFDL +++ D D +A+ I +H + + D L RYIA R
Sbjct: 406 PAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCR 465
Query: 563 SFKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKMHCSGHVT 622
+P++ E + Y + + R L +++RL+ +A++ V
Sbjct: 466 EKQPMVPESLADYITAAYVEMRREAWASKDATY-TSARTLLAILRLSTALARLRMVDVVE 524
Query: 623 PAHVHEAYRLLNKS 636
V+EA RL+ S
Sbjct: 525 KEDVNEAIRLMEMS 538
Score = 52.8 bits (121), Expect = 5e-06
Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 20/136 (14%)
Query: 122 VRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF------------YTIPT-----ICRN 164
+RE+ +G L+ + G + R V P++V T+ PT +C +
Sbjct: 47 IREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPS 106
Query: 165 PVCANRR---RFMLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAG 221
C R R L S F+ FQ++++QE ++P G IPRS+ V++ E Q G
Sbjct: 107 QECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPG 166
Query: 222 DRYDFTGTLIVVPDVG 237
D TG + + G
Sbjct: 167 DHVSVTGIFLPILRTG 182
>D55716-1|BAA09534.1| 719|Homo sapiens P1cdc47 protein.
Length = 719
Score = 252 bits (616), Expect = 5e-66
Identities = 132/314 (42%), Positives = 189/314 (60%), Gaps = 4/314 (1%)
Query: 325 DRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAK 384
+ + Y L S+ P I+G+ +VK+ +LL+L GGV ++ G +RG+IN+C++GDP AK
Sbjct: 329 EEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSP-RGMKIRGNINICLMGDPGVAK 387
Query: 385 SQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEF 444
SQLL + + PR+ YT+G+ SS GLTAAV+RD S + +E GAL+LAD GVCCIDEF
Sbjct: 388 SQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEF 447
Query: 445 DKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVAL 504
DKM D+ AIHE MEQQTIS+AKAG+ TLNAR SILAAANP GRY+ +SL+QN+ L
Sbjct: 448 DKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQL 507
Query: 505 SPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL--RYIAFAR 562
++SRFDL +++ D D +A+ I +H + + D L RYIA R
Sbjct: 508 PAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCR 567
Query: 563 SFKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKMHCSGHVT 622
+P++ E + Y + + R L +++RL+ +A++ V
Sbjct: 568 EKQPMVPESLADYITAAYVEMRREAWASKDATY-TSARTLLAILRLSTALARLRMVDVVE 626
Query: 623 PAHVHEAYRLLNKS 636
V+EA RL+ S
Sbjct: 627 KEDVNEAIRLMEMS 640
Score = 52.8 bits (121), Expect = 5e-06
Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 20/136 (14%)
Query: 122 VRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF------------YTIPT-----ICRN 164
+RE+ +G L+ + G + R V P++V T+ PT +C +
Sbjct: 149 IREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPS 208
Query: 165 PVCANRR---RFMLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAG 221
C R R L S F+ FQ++++QE ++P G IPRS+ V++ E Q G
Sbjct: 209 QECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPG 268
Query: 222 DRYDFTGTLIVVPDVG 237
D TG + + G
Sbjct: 269 DHVSVTGIFLPILRTG 284
>D28480-1|BAA05839.1| 543|Homo sapiens hMCM2 protein.
Length = 543
Score = 252 bits (616), Expect = 5e-66
Identities = 132/314 (42%), Positives = 189/314 (60%), Gaps = 4/314 (1%)
Query: 325 DRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAK 384
+ + Y L S+ P I+G+ +VK+ +LL+L GGV ++ G +RG+IN+C++GDP AK
Sbjct: 153 EEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSP-RGMKIRGNINICLMGDPGVAK 211
Query: 385 SQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEF 444
SQLL + + PR+ YT+G+ SS GLTAAV+RD S + +E GAL+LAD GVCCIDEF
Sbjct: 212 SQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEF 271
Query: 445 DKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVAL 504
DKM D+ AIHE MEQQTIS+AKAG+ TLNAR SILAAANP GRY+ +SL+QN+ L
Sbjct: 272 DKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQL 331
Query: 505 SPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL--RYIAFAR 562
++SRFDL +++ D D +A+ I +H + + D L RYIA R
Sbjct: 332 PAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCR 391
Query: 563 SFKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKMHCSGHVT 622
+P++ E + Y + + R L +++RL+ +A++ V
Sbjct: 392 EKQPMVPESLADYITAAYVEMRREAWASKDATY-TSARTLLAILRLSTALARLRMVDVVE 450
Query: 623 PAHVHEAYRLLNKS 636
V+EA RL+ S
Sbjct: 451 KEDVNEAIRLMEMS 464
Score = 46.8 bits (106), Expect = 3e-04
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 161 ICRNPVCANRR---RFMLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVES 217
+C + C R R L S F+ FQ++++QE ++P G IPRS+ V++ E
Sbjct: 29 MCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRI 88
Query: 218 VQAGDRYDFTGTLIVVPDVG 237
Q GD TG + + G
Sbjct: 89 AQPGDHVSVTGIFLPILRTG 108
>BC013375-1|AAH13375.1| 719|Homo sapiens minichromosome maintenance
complex component 7 protein.
Length = 719
Score = 252 bits (616), Expect = 5e-66
Identities = 132/314 (42%), Positives = 189/314 (60%), Gaps = 4/314 (1%)
Query: 325 DRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAK 384
+ + Y L S+ P I+G+ +VK+ +LL+L GGV ++ G +RG+IN+C++GDP AK
Sbjct: 329 EEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSP-RGMKIRGNINICLMGDPGVAK 387
Query: 385 SQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEF 444
SQLL + + PR+ YT+G+ SS GLTAAV+RD S + +E GAL+LAD GVCCIDEF
Sbjct: 388 SQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEF 447
Query: 445 DKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVAL 504
DKM D+ AIHE MEQQTIS+AKAG+ TLNAR SILAAANP GRY+ +SL+QN+ L
Sbjct: 448 DKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQL 507
Query: 505 SPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLL--RYIAFAR 562
++SRFDL +++ D D +A+ I +H + + D L RYIA R
Sbjct: 508 PAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCR 567
Query: 563 SFKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKMHCSGHVT 622
+P++ E + Y + + R L +++RL+ +A++ V
Sbjct: 568 EKQPMVPESLADYITAAYVEMRREAWASKDATY-TSARTLLAILRLSTALARLRMVDVVE 626
Query: 623 PAHVHEAYRLLNKS 636
V+EA RL+ S
Sbjct: 627 KEDVNEAIRLMEMS 640
Score = 52.8 bits (121), Expect = 5e-06
Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 20/136 (14%)
Query: 122 VRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF------------YTIPT-----ICRN 164
+RE+ +G L+ + G + R V P++V T+ PT +C +
Sbjct: 149 IREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPS 208
Query: 165 PVCANRR---RFMLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAG 221
C R R L S F+ FQ++++QE ++P G IPRS+ V++ E Q G
Sbjct: 209 QECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPG 268
Query: 222 DRYDFTGTLIVVPDVG 237
D TG + + G
Sbjct: 269 DHVSVTGIFLPILRTG 284
>D21063-1|BAA04642.1| 914|Homo sapiens KIAA0030 protein.
Length = 914
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 209 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 268
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 269 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 325
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 326 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 379
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 380 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 438
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 439 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 477
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 478 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 537
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 538 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 597
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 598 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 657
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 658 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 717
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 718 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 775
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 776 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 817
>BT009734-1|AAP88736.1| 895|Homo sapiens MCM2 minichromosome
maintenance deficient 2, mitotin (S. cerevisiae)
protein.
Length = 895
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 190 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 249
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 250 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 306
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 307 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 360
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 361 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 419
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 420 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 458
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 459 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 518
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 519 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 578
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 579 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 638
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 639 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 698
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 699 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 756
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 757 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 798
>BC030131-1|AAH30131.2| 808|Homo sapiens MCM2 protein protein.
Length = 808
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 103 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 162
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 163 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 219
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 220 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 273
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 274 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 332
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 333 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 371
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 372 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 431
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 432 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 491
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 492 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 551
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 552 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 611
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 612 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 669
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 670 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 711
>BC017490-1|AAH17490.2| 904|Homo sapiens minichromosome maintenance
complex component 2 protein.
Length = 904
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>BC014272-1|AAH14272.2| 904|Homo sapiens minichromosome maintenance
complex component 2 protein.
Length = 904
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>BC007938-1|AAH07938.2| 904|Homo sapiens minichromosome maintenance
complex component 2 protein.
Length = 904
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>BC007670-1|AAH07670.2| 904|Homo sapiens minichromosome maintenance
complex component 2 protein.
Length = 904
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>AY675259-1|AAT70723.1| 904|Homo sapiens MCM2 minichromosome
maintenance deficient 2, mitotin (S. cerevisiae)
protein.
Length = 904
Score = 247 bits (605), Expect = 1e-64
Identities = 190/642 (29%), Positives = 309/642 (48%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>BC006165-1|AAH06165.3| 904|Homo sapiens minichromosome maintenance
complex component 2 protein.
Length = 904
Score = 246 bits (601), Expect = 3e-64
Identities = 189/642 (29%), Positives = 308/642 (47%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI + + P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYTKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>BC017258-1|AAH17258.2| 904|Homo sapiens minichromosome maintenance
complex component 2 protein.
Length = 904
Score = 244 bits (597), Expect = 1e-63
Identities = 189/642 (29%), Positives = 308/642 (47%), Gaps = 57/642 (8%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 199 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 259 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 315
Query: 144 HPVHPELVQGTFYTIP-TICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCI 202
V P+L + P C ++ + + + Q E E I
Sbjct: 316 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQ---EVKPGSCPECQSAGPFEVNME---ETI 369
Query: 203 PRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEG 262
++ + I E+ V AG R + I++ D+ PG E+T +G +
Sbjct: 370 YQNYQRIRIQESPGKVAAG-RLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNT 428
Query: 263 IKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEM 322
G + T LA V + EL TD++ + +
Sbjct: 429 ANGFPV-------FATVILANHVAKKDNKVAVGEL--------------TDEDVKMITSL 467
Query: 323 SRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPST 382
S+D+ + + S+ PSI+G+ ++KRG+ L LF G K +RGDINV + GDP T
Sbjct: 468 SKDQQIGEKIFASIAPSIYGHEDIKRGLALALFRGEPKNPGGKHKVRGDINVLLCGDPGT 527
Query: 383 AKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCID 442
AKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC ID
Sbjct: 528 AKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLID 587
Query: 443 EFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNV 502
EFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV
Sbjct: 588 EFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENV 647
Query: 503 ALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYD 546
L+ PI+SRFD+ ++ D + D +AR +V H NKEE +
Sbjct: 648 DLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMP 707
Query: 547 CVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVR 600
Y ++ L +YI +A+ P + + + + Y ITVR
Sbjct: 708 NTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVR 765
Query: 601 QLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
+ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 766 HIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 807
>D83987-1|BAA12177.1| 895|Homo sapiens huMCM2 protein.
Length = 895
Score = 243 bits (594), Expect = 2e-63
Identities = 137/355 (38%), Positives = 212/355 (59%), Gaps = 24/355 (6%)
Query: 310 QMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLR 369
++TD++ + +S+D+ + + S+ PSI+G+ ++KRG+ L LFGG K +R
Sbjct: 446 ELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVR 505
Query: 370 GDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAG 429
GDINV + GDP TAKSQ LK + +++ RA++T+G+ +SA GLTA V R S ++ +EAG
Sbjct: 506 GDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAG 565
Query: 430 ALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIG 489
AL+LAD GVC IDEFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIG
Sbjct: 566 ALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIG 625
Query: 490 GRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE- 543
GRYD + + +NV L+ PI+SRFD+ ++ D + D +AR +V H NKEE
Sbjct: 626 GRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEE 685
Query: 544 ----------SYDCVYS-----RDDLLRYIAFARS-FKPVITEEAGKLLVEYYXXXXXXX 587
+ Y ++ L +YI +A+ P + + + + Y
Sbjct: 686 GLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKES 745
Query: 588 XXXXXXXWRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
ITVR +ESM+R+AE A++H +V V+ A R++ +S I ++
Sbjct: 746 MATGSI--PITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQK 798
Score = 66.9 bits (156), Expect = 3e-10
Identities = 51/221 (23%), Positives = 102/221 (46%), Gaps = 20/221 (9%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 190 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 249
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 250 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 306
Query: 144 HPVHPELVQGTF------YTIPTICRN----------PVCANRRRFMLDADKSVFVDFQK 187
V P+L + + + C++ P C + F ++ +++++ ++Q+
Sbjct: 307 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQR 366
Query: 188 IRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTG 228
IRIQE+ ++ G +PRS + IL A+ V+S AGD + TG
Sbjct: 367 IRIQESPGKVAAGRLPRSKDAILLADLVDSCNAGDEIELTG 407
>X67334-1|CAA47749.1| 892|Homo sapiens polypeptide BM28 protein.
Length = 892
Score = 225 bits (550), Expect = 5e-58
Identities = 110/239 (46%), Positives = 163/239 (68%), Gaps = 5/239 (2%)
Query: 310 QMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLR 369
++TD++ + +S+D+ + + S+ PSI+G+ ++KRG L LFGG K +R
Sbjct: 444 ELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGPALALFGGEPKNPGGKHKVR 503
Query: 370 GDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAG 429
GDINV + GDP TAKSQ LK + +++ RA++T+G+ +SA +TA V R S ++ +EAG
Sbjct: 504 GDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVAVTAYVQRHPVSREWTLEAG 563
Query: 430 ALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIG 489
AL+LAD GVC IDEFDKM+ D+ +IHEAMEQQ+IS++KAG+ +L AR +++AAANPIG
Sbjct: 564 ALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIG 623
Query: 490 GRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLH-----CNKEE 543
GRYD + + +NV L+ PI+SRFD+ ++ D + D +AR +V H NKEE
Sbjct: 624 GRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEE 682
Score = 63.7 bits (148), Expect = 2e-09
Identities = 50/221 (22%), Positives = 101/221 (45%), Gaps = 20/221 (9%)
Query: 25 FQDFLEEFKEDNEIK-YEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPF 83
F++FL + + +++ ++ K +L V+++D+ LA + E +
Sbjct: 188 FKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 247
Query: 84 LNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRT 143
+ A L +L++ K D +V +P ++R L + LIR SG +
Sbjct: 248 FDEAALEVVLAMYP---KYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSC 304
Query: 144 HPVHPELVQGTF------YTIPTICRN----------PVCANRRRFMLDADKSVFVDFQK 187
V P+L + + + C++ P C + F ++ +++++ ++Q+
Sbjct: 305 TGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQR 364
Query: 188 IRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTG 228
IRIQE+ ++ +PRS + IL A+ V+S AGD + TG
Sbjct: 365 IRIQESPGKVAARRLPRSKDAILLADLVDSCNAGDEIELTG 405
>BC101057-1|AAI01058.1| 840|Homo sapiens MCM8 protein protein.
Length = 840
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 318 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 345
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 346 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 405
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 406 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 465
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 466 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 525
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 526 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 584
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 585 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 619
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 666 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 723
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 724 ARLELREEATKEDAEDIVEIMKYSML 749
>BC101056-1|AAI01057.1| 840|Homo sapiens minichromosome maintenance
complex component 8 protein.
Length = 840
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 318 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 345
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 346 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 405
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 406 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 465
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 466 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 525
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 526 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 584
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 585 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 619
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 666 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 723
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 724 ARLELREEATKEDAEDIVEIMKYSML 749
>BC080656-1|AAH80656.1| 840|Homo sapiens minichromosome maintenance
complex component 8 protein.
Length = 840
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 318 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 345
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 346 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 405
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 406 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 465
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 466 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 525
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 526 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 584
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 585 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 619
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 666 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 723
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 724 ARLELREEATKEDAEDIVEIMKYSML 749
>BC008830-1|AAH08830.2| 735|Homo sapiens MCM8 protein protein.
Length = 735
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 153 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 212
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 213 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 240
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 241 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 300
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 301 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 360
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 361 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 420
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 421 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 479
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 480 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 514
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 561 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 618
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 619 ARLELREEATKEDAEDIVEIMKYSML 644
>AL035461-6|CAB55276.2| 840|Homo sapiens MCM8 minichromosome
maintenance deficient 8 (S. cerevisiae) protein.
Length = 840
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 318 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 345
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 346 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 405
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 406 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 465
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 466 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 525
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 526 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 584
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 585 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 619
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 666 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 723
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 724 ARLELREEATKEDAEDIVEIMKYSML 749
>AK027644-1|BAB55260.1| 603|Homo sapiens protein ( Homo sapiens
cDNA FLJ14738 fis, clone NT2RP3002399, weakly similar to
DNA REPLICATION LICENSING FACTOR MCM4. ).
Length = 603
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 21 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 80
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 81 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 108
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 109 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 168
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 169 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 228
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 229 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 288
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 289 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 347
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 348 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 382
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 429 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 486
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 487 ARLELREEATKEDAEDIVEIMKYSML 512
>AJ439063-1|CAD27750.1| 840|Homo sapiens minichromosome maintenance
8 protein.
Length = 840
Score = 225 bits (550), Expect = 5e-58
Identities = 142/395 (35%), Positives = 214/395 (54%), Gaps = 39/395 (9%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVR 272
+ V+S +PG IT K++N + G R
Sbjct: 318 DLVDSC----------------------VPGDTVTITGIVKVSNAEE----------GSR 345
Query: 273 ELHYKTAFLA-CSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNN 331
+ K FL ++S G + D M + + K+ + E+ + NL+
Sbjct: 346 NKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKL 405
Query: 332 LITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLK 389
++ SL P I G+ VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 406 IVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQ 465
Query: 390 QVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDP 449
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 466 AACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN 525
Query: 450 GDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIM 509
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++
Sbjct: 526 QHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALL 584
Query: 510 SRFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
SRFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 585 SRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 619
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 666 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 723
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 724 ARLELREEATKEDAEDIVEIMKYSML 749
>AY007130-1|AAG01994.1| 351|Homo sapiens protein ( Homo sapiens
clone CDABP0042 mRNA sequence. ).
Length = 351
Score = 223 bits (544), Expect = 3e-57
Identities = 117/271 (43%), Positives = 163/271 (60%), Gaps = 3/271 (1%)
Query: 368 LRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIE 427
+RG+IN+C++GDP AKSQLL + + PR+ YT+G+ SS GLTAAV+RD S + +E
Sbjct: 3 IRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLE 62
Query: 428 AGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANP 487
GAL+LAD GVCCIDEFDKM D+ AIHE MEQQTIS+AKAG+ TLNAR SILAAANP
Sbjct: 63 GGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANP 122
Query: 488 IGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDC 547
GRY+ +SL+QN+ L ++SRFDL +++ D D +A+ I +H + +
Sbjct: 123 AYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQ 182
Query: 548 VYSRDDLL--RYIAFARSFKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESM 605
D L RYIA R +P++ E + Y + + R L ++
Sbjct: 183 FEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY-TSARTLLAI 241
Query: 606 VRLAEGVAKMHCSGHVTPAHVHEAYRLLNKS 636
+RL+ +A++ V V+EA RL+ S
Sbjct: 242 LRLSTALARLRMVDVVEKEDVNEAIRLMEMS 272
>AY158211-1|AAO21222.1| 824|Homo sapiens MCM8 isoform protein.
Length = 824
Score = 209 bits (511), Expect = 3e-53
Identities = 106/260 (40%), Positives = 160/260 (61%), Gaps = 3/260 (1%)
Query: 287 AVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEV 346
++S G + D M + + K+ + E+ + NL+ ++ SL P I G+ V
Sbjct: 345 SISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELV 404
Query: 347 KRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGK 404
K G+ L LFGG K + + RGD ++ +VGDP KSQ+L+ + PR VY G
Sbjct: 405 KAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGN 464
Query: 405 ASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTI 464
++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM Q A+ EAMEQQ+I
Sbjct: 465 TTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSI 523
Query: 465 SLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSE 524
SLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++SRFDL FIL+D +E
Sbjct: 524 SLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNE 583
Query: 525 MVDYAIARKIVDLHCNKEES 544
D+ ++ ++ + K+ +
Sbjct: 584 HHDHLLSEHVIAIRAGKQRT 603
Score = 50.8 bits (116), Expect = 2e-05
Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 6/111 (5%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGI 263
+ V+S GD TG + V A S+ S+ + +TK + +G G+
Sbjct: 318 DLVDSCVPGDTVTITGIVKVSNAEEANSISNSKGQ---KTKSSEDGCKHGM 365
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 650 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 707
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 708 ARLELREEATKEDAEDIVEIMKYSML 733
>AL035461-7|CAI23480.1| 824|Homo sapiens MCM8 minichromosome
maintenance deficient 8 (S. cerevisiae) protein.
Length = 824
Score = 209 bits (511), Expect = 3e-53
Identities = 106/260 (40%), Positives = 160/260 (61%), Gaps = 3/260 (1%)
Query: 287 AVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEV 346
++S G + D M + + K+ + E+ + NL+ ++ SL P I G+ V
Sbjct: 345 SISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELV 404
Query: 347 KRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGK 404
K G+ L LFGG K + + RGD ++ +VGDP KSQ+L+ + PR VY G
Sbjct: 405 KAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGN 464
Query: 405 ASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTI 464
++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM Q A+ EAMEQQ+I
Sbjct: 465 TTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSI 523
Query: 465 SLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSE 524
SLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++SRFDL FIL+D +E
Sbjct: 524 SLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNE 583
Query: 525 MVDYAIARKIVDLHCNKEES 544
D+ ++ ++ + K+ +
Sbjct: 584 HHDHLLSEHVIAIRAGKQRT 603
Score = 50.8 bits (116), Expect = 2e-05
Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 6/111 (5%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGI 263
+ V+S GD TG + V A S+ S+ + +TK + +G G+
Sbjct: 318 DLVDSCVPGDTVTITGIVKVSNAEEANSISNSKGQ---KTKSSEDGCKHGM 365
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 650 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 707
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 708 ARLELREEATKEDAEDIVEIMKYSML 733
>AK160378-1|BAD18721.1| 450|Homo sapiens FLJ00323 protein protein.
Length = 450
Score = 195 bits (475), Expect = 6e-49
Identities = 97/214 (45%), Positives = 140/214 (65%), Gaps = 3/214 (1%)
Query: 333 ITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLKQ 390
+TS+F S VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+
Sbjct: 17 LTSVFCSFFALELVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQA 76
Query: 391 VSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPG 450
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM
Sbjct: 77 ACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQ 136
Query: 451 DQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMS 510
Q A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++S
Sbjct: 137 HQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLS 195
Query: 511 RFDLFFILIDESSEMVDYAIARKIVDLHCNKEES 544
RFDL FIL+D +E D+ ++ ++ + K+ +
Sbjct: 196 RFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 229
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 276 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 333
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 334 ARLELREEATKEDAEDIVEIMKYSML 359
>BC101055-1|AAI01056.1| 880|Homo sapiens MCM8 protein protein.
Length = 880
Score = 190 bits (462), Expect = 2e-47
Identities = 93/201 (46%), Positives = 134/201 (66%), Gaps = 3/201 (1%)
Query: 346 VKRGVLLMLFGGVAKTTIEGTTL--RGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSG 403
VK G+ L LFGG K + + RGD ++ +VGDP KSQ+L+ + PR VY G
Sbjct: 460 VKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCG 519
Query: 404 KASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQT 463
++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM Q A+ EAMEQQ+
Sbjct: 520 NTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQS 578
Query: 464 ISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESS 523
ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++SRFDL FIL+D +
Sbjct: 579 ISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLAFILLDTPN 638
Query: 524 EMVDYAIARKIVDLHCNKEES 544
E D+ ++ ++ + K+ +
Sbjct: 639 EHHDHLLSEHVIAIRAGKQRT 659
Score = 46.8 bits (106), Expect = 3e-04
Identities = 30/80 (37%), Positives = 44/80 (55%), Gaps = 3/80 (3%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIV 232
+ V+S GD TG + V
Sbjct: 318 DLVDSCVPGDTVTITGIVKV 337
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 706 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 763
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 764 ARLELREEATKEDAEDIVEIMKYSML 789
>BC000300-1|AAH00300.2| 362|Homo sapiens MCM2 protein protein.
Length = 362
Score = 167 bits (406), Expect = 1e-40
Identities = 102/267 (38%), Positives = 155/267 (58%), Gaps = 24/267 (8%)
Query: 398 AVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHE 457
A++T+G+ +SA GLTA V R S ++ +EAGAL+LAD GVC IDEFDKM+ D+ +IHE
Sbjct: 1 AIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHE 60
Query: 458 AMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFI 517
AMEQQ+IS++KAG+ +L AR +++AAANPIGGRYD + + +NV L+ PI+SRFD+ +
Sbjct: 61 AMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCV 120
Query: 518 LIDESSEMVDYAIARKIVDLH-----CNKEE-----------SYDCVYS-----RDDLLR 556
+ D + D +AR +V H NKEE + Y ++ L +
Sbjct: 121 VRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKK 180
Query: 557 YIAFARS-FKPVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGVAKM 615
YI +A+ P + + + + Y ITVR +ESM+R+AE A++
Sbjct: 181 YIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSI--PITVRHIESMIRMAEAHARI 238
Query: 616 HCSGHVTPAHVHEAYRLLNKSIIRVEQ 642
H +V V+ A R++ +S I ++
Sbjct: 239 HLRDYVIEDDVNMAIRVMLESFIDTQK 265
>BC101054-1|AAI01055.1| 793|Homo sapiens MCM8 protein protein.
Length = 793
Score = 156 bits (378), Expect = 3e-37
Identities = 73/151 (48%), Positives = 106/151 (70%), Gaps = 1/151 (0%)
Query: 394 ITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQV 453
+ PR VY G ++ +GLT + +D S DF +EAGAL+L D G+C IDEFDKM Q
Sbjct: 423 VAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ- 481
Query: 454 AIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFD 513
A+ EAMEQQ+ISLAKAGV +L ARTSI+AAANP+GG Y++AK++ +N+ + ++SRFD
Sbjct: 482 ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFD 541
Query: 514 LFFILIDESSEMVDYAIARKIVDLHCNKEES 544
L FIL+D +E D+ ++ ++ + K+ +
Sbjct: 542 LVFILLDTPNEHHDHLLSEHVIAIRAGKQRT 572
Score = 46.8 bits (106), Expect = 3e-04
Identities = 30/80 (37%), Positives = 44/80 (55%), Gaps = 3/80 (3%)
Query: 156 YTIPTICRNPVCANRRRFMLDADK-SVFVDFQKIRIQETQAELPR--GCIPRSLEVILRA 212
Y++PT C PVC R L + +V +D+Q I+IQE ++ R G IPR++E L
Sbjct: 258 YSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVH 317
Query: 213 EAVESVQAGDRYDFTGTLIV 232
+ V+S GD TG + V
Sbjct: 318 DLVDSCVPGDTVTITGIVKV 337
Score = 39.1 bits (87), Expect = 0.061
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 554 LLRYIAFARSFK-PVITEEAGKLLVEYYXXXXXXXXXXXXXXWRITVRQLESMVRLAEGV 612
L +YI +AR + P ++ EA ++L ++Y IT RQLES++RL E
Sbjct: 619 LRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSP--ITTRQLESLIRLTEAR 676
Query: 613 AKMHCSGHVTPAHVHEAYRLLNKSII 638
A++ T + ++ S++
Sbjct: 677 ARLELREEATKEDAEDIVEIMKYSML 702
>U67284-1|AAB48165.1| 181|Homo sapiens homolog of S. pombe mis5
protein.
Length = 181
Score = 143 bits (346), Expect = 3e-33
Identities = 81/192 (42%), Positives = 125/192 (65%), Gaps = 26/192 (13%)
Query: 621 VTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEP--NGTAETPS----- 673
V P HV EA+RLLNKSIIRVE PD++LD++E E M+VD+ NG A++P+
Sbjct: 1 VQPKHVKEAFRLLNKSIIRVETPDVNLDQEE---EIQMEVDEGAGGINGHADSPAPVNGI 57
Query: 674 -------NGDSAPKKKLALSFEEYKSLSNMLVVYMRKXXXXXXXXXXXSSGMHKSAVVSW 726
N +SAPK L L F EY +SN++V+++RK S + +S +V+W
Sbjct: 58 NGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEED------ESALKRSELVNW 111
Query: 727 YLEQLVAQGQIESEDELLERKTLVEKVIDRLMYHDQVIIPLSTTGLRGTQKSSEQDIEDD 786
YL+++ + +I+SE+EL+ +K ++EKVI RL ++D V+I L+ GL+G+ + SE E+D
Sbjct: 112 YLKEI--ESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSE-SYEED 168
Query: 787 PLLVVHPNYVVD 798
P LVV+PNY+++
Sbjct: 169 PYLVVNPNYLLE 180
>AL132874-5|CAI42607.1| 451|Homo sapiens protein ( an). ).).
Length = 451
Score = 84.6 bits (200), Expect = 1e-15
Identities = 50/148 (33%), Positives = 82/148 (55%), Gaps = 5/148 (3%)
Query: 475 LNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKI 534
LN RT+ILAA NP G+YD +S+ N+AL P++SRFDL +L+D +E D I+ I
Sbjct: 290 LNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFI 348
Query: 535 VDLHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYXXXXXXXXXXXXXX 594
++ +S + ++S + + Y R+ +P +++ ++L+ YY
Sbjct: 349 LENKGYPSKS-EKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAA-- 405
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVT 622
R T+R LES++RLAE A++ VT
Sbjct: 406 -RTTIRLLESLIRLAEAHARLMFRDTVT 432
Score = 78.2 bits (184), Expect = 1e-13
Identities = 42/107 (39%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 305 EDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIE 364
E+++K+ D W+ Y S N ++ SL P + G VK V ++L GG+ +T
Sbjct: 172 EEVQKEFEDF-WE--YYKSDPFAGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAT 228
Query: 365 GTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGL 411
GT +RG+ ++ +VGDP T KSQ LK ++ITPR+V T+G S++AG+
Sbjct: 229 GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 275
Score = 41.9 bits (94), Expect = 0.009
Identities = 20/48 (41%), Positives = 31/48 (64%)
Query: 184 DFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLI 231
D+Q+I+IQE L G IPRS++VIL + V+S ++GD G ++
Sbjct: 88 DYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVM 135
>BC031658-1|AAH31658.1| 391|Homo sapiens minichromosome maintenance
complex component 9 protein.
Length = 391
Score = 78.2 bits (184), Expect = 1e-13
Identities = 42/107 (39%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 305 EDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIE 364
E+++K+ D W+ Y S N ++ SL P + G VK V ++L GG+ +T
Sbjct: 282 EEVQKEFEDF-WE--YYKSDPFAGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAT 338
Query: 365 GTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGL 411
GT +RG+ ++ +VGDP T KSQ LK ++ITPR+V T+G S++AG+
Sbjct: 339 GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Score = 41.9 bits (94), Expect = 0.009
Identities = 20/48 (41%), Positives = 31/48 (64%)
Query: 184 DFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLI 231
D+Q+I+IQE L G IPRS++VIL + V+S ++GD G ++
Sbjct: 198 DYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVM 245
>AL132874-4|CAI42606.1| 156|Homo sapiens protein ( Human DNA
sequence from clone RP3-329L24 on chromosome
6q22.1-22.33.om chromosome 14 of Homo sapiens (Human).
).
Length = 156
Score = 78.2 bits (184), Expect = 1e-13
Identities = 42/107 (39%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 305 EDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIE 364
E+++K+ D W+ Y S N ++ SL P + G VK V ++L GG+ +T
Sbjct: 47 EEVQKEFEDF-WE--YYKSDPFAGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAT 103
Query: 365 GTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGL 411
GT +RG+ ++ +VGDP T KSQ LK ++ITPR+V T+G S++AG+
Sbjct: 104 GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 150
>BC009398-1|AAH09398.1| 389|Homo sapiens MCM7 protein protein.
Length = 389
Score = 52.8 bits (121), Expect = 5e-06
Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 20/136 (14%)
Query: 122 VRELTTAKIGTLIRISGQIVRTHPVHPELVQGTF------------YTIPT-----ICRN 164
+RE+ +G L+ + G + R V P++V T+ PT +C +
Sbjct: 149 IREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPS 208
Query: 165 PVCANRR---RFMLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAG 221
C R R L S F+ FQ++++QE ++P G IPRS+ V++ E Q G
Sbjct: 209 QECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPG 268
Query: 222 DRYDFTGTLIVVPDVG 237
D TG + + G
Sbjct: 269 DHVSVTGIFLPILRTG 284
>AL034343-2|CAD92644.1| 328|Homo sapiens MCM3 minichromosome
maintenance deficient 3 (S. cerevisiae) protein.
Length = 328
Score = 45.6 bits (103), Expect = 7e-04
Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 7/134 (5%)
Query: 537 LHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYX--XXXXXXXXXXXXX 594
LH K++ V S + +YI A+ KPV+T+E+ + E Y
Sbjct: 47 LHGTKKKKEKMV-SAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTART 105
Query: 595 WRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLN----KSIIRVEQPDIHLDED 650
+T R LE+++RLA AK S V EA L+ K ++ E+ ED
Sbjct: 106 SPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSED 165
Query: 651 EPQCEPSMDVDQDE 664
E + E + Q++
Sbjct: 166 ESETEDEEEKSQED 179
>U09584-1|AAA92281.1| 351|Homo sapiens PL6 protein protein.
Length = 351
Score = 33.5 bits (73), Expect = 3.0
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 629 AYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEPNGTAETPSNGDSAPKKKLALSFE 688
A + LN+ + RVE I D+ + E VD P+ A TP +AP+ L ++FE
Sbjct: 287 ALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSL-ITFE 345
>CR457020-1|CAG33301.1| 351|Homo sapiens PL6 protein.
Length = 351
Score = 33.5 bits (73), Expect = 3.0
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 629 AYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEPNGTAETPSNGDSAPKKKLALSFE 688
A + LN+ + RVE I D+ + E VD P+ A TP +AP+ L ++FE
Sbjct: 287 ALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSL-ITFE 345
>BC017367-1|AAH17367.1| 351|Homo sapiens transmembrane protein 115
protein.
Length = 351
Score = 33.5 bits (73), Expect = 3.0
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 629 AYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEPNGTAETPSNGDSAPKKKLALSFE 688
A + LN+ + RVE I D+ + E VD P+ A TP +AP+ L ++FE
Sbjct: 287 ALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSL-ITFE 345
>BC011948-1|AAH11948.1| 351|Homo sapiens transmembrane protein 115
protein.
Length = 351
Score = 33.5 bits (73), Expect = 3.0
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 629 AYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEPNGTAETPSNGDSAPKKKLALSFE 688
A + LN+ + RVE I D+ + E VD P+ A TP +AP+ L ++FE
Sbjct: 287 ALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSL-ITFE 345
>AC002481-1|AAB67308.1| 247|Homo sapiens PL6 protein, unknown
function but deleted in small cell lung cancer protein.
Length = 247
Score = 33.5 bits (73), Expect = 3.0
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 629 AYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEPNGTAETPSNGDSAPKKKLALSFE 688
A + LN+ + RVE I D+ + E VD P+ A TP +AP+ L ++FE
Sbjct: 183 ALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSL-ITFE 241
>CR457191-1|CAG33472.1| 303|Homo sapiens MRPL1 protein.
Length = 303
Score = 32.3 bits (70), Expect = 6.9
Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 29 LEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEY-YRIYPFLNRA 87
LE FK +EIK ++ + L+ +++TL++S D + Q + + + PF+ RA
Sbjct: 212 LELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRA 271
Query: 88 IL 89
L
Sbjct: 272 FL 273
>BC104483-1|AAI04484.1| 495|Homo sapiens SUV420H1 protein protein.
Length = 495
Score = 32.3 bits (70), Expect = 6.9
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query: 400 YTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAM 459
+ SG SS+ L + RDEE+ E L +NGVCC D ++ +V +
Sbjct: 376 FNSGSGSSSTKLKIQLKRDEENRGSYTEG----LHENGVCCSDPLSLLESRMEVDDYSQY 431
Query: 460 EQQT 463
E+++
Sbjct: 432 EEES 435
>BC103498-1|AAI03499.1| 885|Homo sapiens suppressor of variegation
4-20 homolog 1, isoform 1 protein.
Length = 885
Score = 32.3 bits (70), Expect = 6.9
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query: 400 YTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAM 459
+ SG SS+ L + RDEE+ E L +NGVCC D ++ +V +
Sbjct: 766 FNSGSGSSSTKLKIQLKRDEENRGSYTEG----LHENGVCCSDPLSLLESRMEVDDYSQY 821
Query: 460 EQQT 463
E+++
Sbjct: 822 EEES 825
>BC099714-1|AAH99714.1| 885|Homo sapiens suppressor of variegation
4-20 homolog 1 (Drosophila) protein.
Length = 885
Score = 32.3 bits (70), Expect = 6.9
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query: 400 YTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAM 459
+ SG SS+ L + RDEE+ E L +NGVCC D ++ +V +
Sbjct: 766 FNSGSGSSSTKLKIQLKRDEENRGSYTEG----LHENGVCCSDPLSLLESRMEVDDYSQY 821
Query: 460 EQQT 463
E+++
Sbjct: 822 EEES 825
>BC098121-1|AAH98121.1| 471|Homo sapiens SUV420H1 protein protein.
Length = 471
Score = 32.3 bits (70), Expect = 6.9
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query: 400 YTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAM 459
+ SG SS+ L + RDEE+ E L +NGVCC D ++ +V +
Sbjct: 352 FNSGSGSSSTKLKIQLKRDEENRGSYTEG----LHENGVCCSDPLSLLESRMEVDDYSQY 407
Query: 460 EQQT 463
E+++
Sbjct: 408 EEES 411
>BC032595-1|AAH32595.1| 303|Homo sapiens mitochondrial ribosomal
protein L1 protein.
Length = 303
Score = 32.3 bits (70), Expect = 6.9
Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 29 LEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEY-YRIYPFLNRA 87
LE FK +EIK ++ + L+ +++TL++S D + Q + + + PF+ RA
Sbjct: 212 LELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRA 271
Query: 88 IL 89
L
Sbjct: 272 FL 273
>BC017765-1|AAH17765.1| 302|Homo sapiens Unknown (protein for
IMAGE:4284885) protein.
Length = 302
Score = 32.3 bits (70), Expect = 6.9
Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 29 LEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEY-YRIYPFLNRA 87
LE FK +EIK ++ + L+ +++TL++S D + Q + + + PF+ RA
Sbjct: 212 LELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRA 271
Query: 88 IL 89
L
Sbjct: 272 FL 273
>BC015109-1|AAH15109.1| 303|Homo sapiens mitochondrial ribosomal
protein L1 protein.
Length = 303
Score = 32.3 bits (70), Expect = 6.9
Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 29 LEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEY-YRIYPFLNRA 87
LE FK +EIK ++ + L+ +++TL++S D + Q + + + PF+ RA
Sbjct: 212 LELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRA 271
Query: 88 IL 89
L
Sbjct: 272 FL 273
>BC014356-1|AAH14356.1| 303|Homo sapiens mitochondrial ribosomal
protein L1 protein.
Length = 303
Score = 32.3 bits (70), Expect = 6.9
Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 29 LEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEY-YRIYPFLNRA 87
LE FK +EIK ++ + L+ +++TL++S D + Q + + + PF+ RA
Sbjct: 212 LELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRA 271
Query: 88 IL 89
L
Sbjct: 272 FL 273
>BC012933-1|AAH12933.1| 414|Homo sapiens SUV420H1 protein protein.
Length = 414
Score = 32.3 bits (70), Expect = 6.9
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query: 400 YTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAM 459
+ SG SS+ L + RDEE+ E L +NGVCC D ++ +V +
Sbjct: 295 FNSGSGSSSTKLKIQLKRDEENRGSYTEG----LHENGVCCSDPLSLLESRMEVDDYSQY 350
Query: 460 EQQT 463
E+++
Sbjct: 351 EEES 354
>AK000046-1|BAA90905.1| 414|Homo sapiens protein ( Homo sapiens
cDNA FLJ20039 fis, clone COL00364. ).
Length = 414
Score = 32.3 bits (70), Expect = 6.9
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Query: 400 YTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAM 459
+ SG SS+ L + RDEE+ E L +NGVCC D ++ +V +
Sbjct: 295 FNSGSGSSSTKLKIQLKRDEENRGSYTEG----LHENGVCCSDPLSLLESRMEVDDYSQY 350
Query: 460 EQQT 463
E+++
Sbjct: 351 EEES 354
>AC011999-1|AAY15028.1| 35|Homo sapiens unknown protein.
Length = 35
Score = 32.3 bits (70), Expect = 6.9
Identities = 13/19 (68%), Positives = 16/19 (84%)
Query: 12 QVKDEVGIRCQKLFQDFLE 30
+V+DEV +CQKLF DFLE
Sbjct: 17 EVRDEVAEKCQKLFLDFLE 35
>AB049474-1|BAB40180.1| 303|Homo sapiens mitochondrial ribosomal
protein L1 (L1mt) protein.
Length = 303
Score = 32.3 bits (70), Expect = 6.9
Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 29 LEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEY-YRIYPFLNRA 87
LE FK +EIK ++ + L+ +++TL++S D + Q + + + PF+ RA
Sbjct: 212 LELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRA 271
Query: 88 IL 89
L
Sbjct: 272 FL 273
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.134 0.380
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 100,796,120
Number of Sequences: 224733
Number of extensions: 3911365
Number of successful extensions: 11174
Number of sequences better than 10.0: 80
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 10876
Number of HSP's gapped (non-prelim): 199
length of query: 799
length of database: 73,234,838
effective HSP length: 96
effective length of query: 703
effective length of database: 51,660,470
effective search space: 36317310410
effective search space used: 36317310410
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 69 (31.9 bits)
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